bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the impact of rural weight loss interventions: A systematic review and meta‐analysis
Authors: Porter Gwenndolyn C. , Laumb Karen , Michaud Tzeyu , Brito Fabiana , Petreca Daniel , Schwieger Gina , Bartee Todd , Yeary Karen H.K. , Estabrooks Paul A. 
Published: January 2019

SummaryRural adults have a higher risk of developing obesity than urban adults. Several evidence‐based interventions have targeted rural regions, but their impact, defined as reach (number and representativeness of participants) by effectiveness, has not been examined. The purpose of this review was to determine the impact of rural weight loss interventions and the availability of data across dimensions of the reach, effectiveness, adoption, implementation, and maintenance (RE‐AIM) framework. A systematic review was conducted to identify rural weight loss interventions that targeted adults. RE‐AIM‐related data were abstracted from each article. We performed a meta‐analysis to examine effectiveness. Sixty‐four articles reported on rural weight loss interventions, describing 50 unique interventions. The median number of participants was 107. Median participation rate differed between values reported by the authors (62%) and values computed using a standard method (32%). Two studies reported on sample representativeness; none reported comparisons made between target and actual delivery settings. Median weight loss per participant was 3.64 kg. Meta‐analyses revealed the interventions achieved a significant weight reduction, and longer‐duration interventions resulted in greater weight loss. Rural weight loss interventions appear to be effective in supporting clinically meaningful weight loss but reach and cost outcomes are still difficult to determine.
Real‐world experience with leadless cardiac pacing
Authors: Vaidya Vaibhav R. , Dai Mingyan , Asirvatham Samuel J. , Rea Robert F. , Thome Trena M. , Srivathsan Komandoor , Mulpuru Siva K. , Kusumoto Fred , Venkatachalam Kalpathi L. , Ryan James D. , Friedman Paul A. , Cha Yong‐Mei 
Published: January 2019

AbstractBackgroundLeadless cardiac pacing (LCP) has emerged as a new modality for permanent pacing. We sought to describe comparative outcomes between LCP and transvenous pacemakers.MethodsPatients receiving LCP (Micra [Medtronic, Minneapolis, MN, USA] and Nanostim [St. Jude Medical/Abbott Laboratories, Chicago, IL, USA]) between 2014 and 2017 at the Mayo Clinic Heart Rhythm Enterprise practice (Rochester, MN, USA; Jacksonville, FL, USA; and Scottsdale, AZ, USA) were identified. We identified 1:1 age‐ and sex‐matched controls receiving single‐chamber transvenous ventricular pacemakers (TVP). Statistical analyses were performed with JMP 13.0.0 (SAS, Institute Cary, NC, USA).ResultsNinety patients underwent LCP implantation (73 Micra and 17 Nanostim) with a median follow‐up duration of 62 (interquartile range 28‐169) days. Both groups had 100% successful device implant rates. There were no differences in procedure‐related major (0% vs 1%) or minor complications (8% vs 3%) in the LCP versus TVP groups (P > 0.05). Excluding Nanostim patients, there was a lower rate of device‐related revision or extraction in the Micra versus TVP groups (0% vs 5%, P = 0.028). Device endocarditis was more common in the TVP group (0% vs 3%, P = 0.04). Estimated longevity was greater for the LCP group (median 12.0 vs 10.0 years, P < 0.0001). An increase in severity of tricuspid valve regurgitation (TR) by ≥2 grades occurred in none of the LCP patients, and in 19% of the TVP patients (P = 0.017).ConclusionThere are no significant differences in procedural complications among patients receiving LCP versus TVP. The Micra group had lower rates of device‐related revision/extraction compared to the TVP group. Patients with leadless pacemaker were less likely to develop endocarditis or worsening TR.
Beyond soil water potential: An expanded view on isohydricity including land–atmosphere interactions and phenology
Authors: Novick Kimberly A. , Konings Alexandra G. , Gentine Pierre 
Published: January 2019

AbstractOver the past decade, the concept of isohydry or anisohydry, which describes the link between soil water potential (ΨS), leaf water potential (ΨL), and stomatal conductance (gs), has soared in popularity. However, its utility has recently been questioned, and a surprising lack of coordination between the dynamics of ΨL and gs across biomes has been reported. Here, we offer a more expanded view of the isohydricity concept that considers effects of vapour pressure deficit (VPD) and leaf area index (AL) on the apparent sensitivities of ΨL and gs to drought. After validating the model with tree‐ and ecosystem‐scale data, we find that within a site, isohydricity is a strong predictor of limitations to stomatal function, though variation in VPD and leaf area, among other factors, can challenge its diagnosis. Across sites, the theory predicts that the degree of isohydricity is a good predictor of the sensitivity of gs to declining soil water in the absence of confounding effects from other drivers. However, if VPD effects are significant, they alone are sufficient to decouple the dynamics of ΨL and gs entirely. We conclude with a set of practical recommendations for future applications of the isohydricity framework within and across sites.
The role of amino acid metabolism during abiotic stress release
Authors: Batista‐Silva Willian , Heinemann Björn , Rugen Nils , Nunes‐Nesi Adriano , Araújo Wagner L. , Braun Hans‐Peter , Hildebrandt Tatjana M. 
Published: January 2019

AbstractPlant responses to abiotic stress include various modifications in amino acid metabolism. By using a hydroponic culture system, we systematically investigate modification in amino acid profiles and the proteome of Arabidopsis thaliana leaves during initial recovery from low water potential or high salinity. Both treatments elicited oxidative stress leading to a biphasic stress response during recovery. Degradation of highly abundant proteins such as subunits of photosystems and ribosomes contributed to an accumulation of free amino acids. Catabolic pathways for several low abundant amino acids were induced indicating their usage as an alternative respiratory substrate to compensate for the decreased photosynthesis. Our results demonstrate that rapid detoxification of potentially detrimental amino acids such as Lys is a priority during the initial stress recovery period. The content of Pro, which acts as a compatible osmolyte during stress, was adjusted by balancing its synthesis and catabolism both of which were induced both during and after stress treatments. The production of amino acid derived secondary metabolites was up‐regulated specifically during the recovery period, and our dataset also indicates increased synthesis rates of the precursor amino acids. Overall, our results support a tight relationship between amino acid metabolism and stress responses.
Income and social communication: The demographics of stock market participation
Authors: Gao Ming , Meng Juanjuan , Zhao Longkai 
Published: January 2019

AbstractThis paper analyses the determinants of stock market participation decisions using officially compiled aggregate stock account opening data in China. Different from the literature that often focuses on one particular dimension, our paper systematically evaluates the relative importance of disposable income, demographic variables, macroeconomic factors, stock market conditions and social communication on both the level and the change of the participation rate. We find that the level of the participation rate is predominately determined by the income factor, followed by various measures of social communication. Social communication plays the most important role in the change of the participation rate, acting as a multiplier to stimulate stock market participation. The effects are more pronounced in high‐income, high‐education, high‐population‐density groups and during the bull market period.
Numerical simulation of the lateral pipe intake: flow and sediment field
Authors: Rahmani Firozjaei Mahmood , Behnamtalab Ehsan , Salehi Neyshabouri Seyed Ali Akbar 
Published: January 2019

AbstractHydraulic characteristics of the flow and sediment transport conditions are among the most important issues in design of the lateral intakes in order to minimize the flow loss. In this study, a 3D numerical model has been employed in a parametric study to study the performance of a lateral pipe intake. Observations indicated that the flow was affected by the pipe intake so that the recirculation area was close to the wall of the main channel, the wall of the lateral pipe intake and back of the lateral pipe intake. The pipe intake in vertical direction to the main channel showed the highest performance, although sedimentation behind the pipe intake in this diversion angle was higher. In addition, pipe intake showed a quite acceptable performance for almost 40% intrusion to the main channel width. Relationships for the coefficient of discharge were also developed.
Termites mitigate the effects of drought in tropical rainforest
Authors: Ashton L. A. , Griffiths H. M. , Parr C. L. , Evans T. A. , Didham R. K. , Hasan F. , Teh Y. A. , Tin H. S. , Vairappan C. S. , Eggleton P. 
Published: January 2019

Forest termites mitigate the effects of droughtIn many tropical regions, where drought is predicted to become more frequent in the coming years, termites are key components of ecosystem function. Ashtonet al.experimentally manipulated termite communities to quantify their role during the 2015–2016 “super El Niño” drought in a Malaysian tropical rainforest. Termite relative abundance more than doubled in control plots during drought, maintaining three major ecosystem processes: decomposition, nutrient heterogeneity, and moisture retention. Seedling mortality increased where termites were suppressed.Science, this issue p.174
Lifetime economic impact of the burden of childhood stunting attributable to maternal psychosocial risk factors in 137 low/middle-income countries
Authors: Smith Fawzi Mary C , Andrews Kathryn G , Fink Günther , Danaei Goodarz , McCoy Dana Charles , Sudfeld Christopher R , Peet Evan D , Cho Jeanne , Liu Yuanyuan , Finlay Jocelyn E , Ezzati Majid , Kaaya Sylvia F , Fawzi Wafaie W 
Published: January 2019

IntroductionThe first 1000 days of life is a period of great potential and vulnerability. In particular, physical growth of children can be affected by the lack of access to basic needs as well as psychosocial factors, such as maternal depression. The objectives of the present study are to: (1) quantify the burden of childhood stunting in low/middle-income countries attributable to psychosocial risk factors; and (2) estimate the related lifetime economic costs.MethodsA comparative risk assessment analysis was performed with data from 137 low/middle-income countries throughout Asia, Latin America and the Caribbean, North Africa and the Middle East, and sub-Saharan Africa. The proportion of stunting prevalence, defined as <−2 SDs from the median height for age according to the WHO Child Growth Standards, and the number of cases attributable to low maternal education, intimate partner violence (IPV), maternal depression and orphanhood were calculated. The joint effect of psychosocial risk factors on stunting was estimated. The economic impact, as reflected in the total future income losses per birth cohort, was examined.ResultsApproximately 7.2 million cases of stunting in low/middle-income countries were attributable to psychosocial factors. The leading risk factor was maternal depression with 3.2 million cases attributable. Maternal depression also demonstrated the greatest economic cost at $14.5 billion, followed by low maternal education ($10.0 billion) and IPV ($8.5 billion). The joint cost of these risk factors was $29.3 billion per birth cohort.ConclusionThe cost of neglecting these psychosocial risk factors is significant. Improving access to formal secondary school education for girls may offset the risk of maternal depression, IPV and orphanhood. Focusing on maternal depression may play a key role in reducing the burden of stunting. Overall, addressing psychosocial factors among perinatal women can have a significant impact on child growth and well-being in the developing world.
Exercise dependence, eating disorder symptoms and biomarkers of Relative Energy Deficiency in Sports (RED-S) among male endurance athletes
Authors: Torstveit Monica Klungland , Fahrenholtz Ida Lysdahl , Lichtenstein Mia Beck , Stenqvist Thomas Birkedal , Melin Anna Katarina 
Published: January 2019

ObjectivesTo explore associations betweenexercise dependence, eating disorder (ED) symptoms and biomarkers of Relative Energy Deficiency in Sports (RED-S) among male endurance athletes.MethodsFifty-three healthy well-trained male cyclists, triathletes and long-distance runners recruited from regional competitive sports clubs were included in this cross-sectional study. The protocol comprised the Exercise Dependence Scale (EXDS), the ED Examination Questionnaire (EDE-Q), measurements of body composition, resting metabolic rate, energy intake and expenditure and blood analysis of hormones and glucose.ResultsParticipants with higher EXDS score displayed a more negative energy balance compared with subjects with lower EXDS score (p<0.01). EXDS total score was positively correlated with EDE-Q global score (r=0.41, p<0.05) and the subscale score forrestraint eating(r=0.34, p<0.05) andweight concern(r=0.35, p<0.05). EXDS total score and the subscaleslack of controlandtolerancewere positively correlated with cortisol (r=0.38, p<0.01, r=0.39, p<0.01 and r=0.29, p<0.05, respectively). The EXDS subscaleswithdrawalandtolerancewere negatively correlated with fasting blood glucose (r=−0.31 and r=−0.32, p<0.05, respectively), whileintention effectwas negatively correlated with testosterone:cortisol ratio (r=−0.29, p<0.05) and positively correlated with cortisol:insulin ratio (r=0.33, p<0.05).ConclusionIn this sample of healthy male athletes, we found associations between higher EXDS scores, ED symptoms and biomarkers of RED-S, such as a more pronounced negative energy balance and higher cortisol levels.
Timely access to care for patients with critical burns in India: a prehospital prospective observational study
Authors: Newberry Jennifer A , Bills Corey B , Pirrotta Elizabeth A , Barry Michele , Ramana Rao Govindaraju Venkata , Mahadevan Swaminatha V , Strehlow Matthew C 
Published: January 2019

BackgroundLow/middle-income countries carry a disproportionate burden of the morbidity and mortality from thermal burns. Nearly 70% of burn deaths worldwide are from thermal burns in India. Delays to medical care are commonplace and an important predictor of outcomes. We sought to understand the role of emergency medical services (EMS) as part of the healthcare infrastructure for thermal burns in India.MethodsWe conducted a prospective observational study of patients using EMS for thermal burns across five Indian states from May to August 2015. Our primary outcome was mortality at 2, 7 and 30 days. We compared observed mortality with expected mortality using the revised Baux score. We used Χ2analysis for categorical variables and Wilcoxon two-sample test for continuous variables. ORs and 95% CIs are reported for all modelled predictor variables.ResultsWe enrolled 439 patients. The 30-day follow-up rate was 85.9% (n=377). The median age was 30 years; 56.7% (n=249) lived in poverty; and 65.6% (n=288) were women. EMS transported 94.3% of patients (n=399) to the hospital within 2 hours of their call. Median total body surface area (TBSA) burned was 60% overall, and 80% in non-accidental burns. Sixty-eight per cent of patients had revised Baux scores greater than 80. Overall 30-day mortality was 64.5%, and highest (90.2%) in women with non-accidental burns. Predictors of mortality by multivariate regression were TBSA (OR 7.9), inhalation injury (OR 5.5), intentionality (OR 4.7) and gender (OR 2.2).DiscussionAlthough EMS rapidly connects critically burned patients to care in India, mortality remains high, with women disproportionally suffering self-inflicted burns. To combat the burn epidemic in India, efforts must focus on rapid medical care and critical care services, and on a burn prevention strategy that includes mental health and gender-based violence support services.
MicroRNA-92a-1–5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia
Authors: Li Ting , Guo Hanqing , Li Hong , Jiang Yanzhi , Zhuang Kun , Lei Chao , Wu Jian , Zhou Haining , Zhu Ruixue , Zhao Xiaodi , Lu Yuanyuan , Shi Chongkai , Nie Yongzhan , Wu Kaichun , Yuan Zuyi , Fan Dai-Ming , Shi Yongquan 
Published: January 2019

Background and aimsGastric intestinal metaplasia (IM) is common in the gastric epithelium of patients with chronic atrophic gastritis. CDX2 activation in IM is driven by reflux of bile acids and following chronic inflammation. But the mechanism underlying how bile acids activate CDX2 in gastric epithelium has not been fully explored.MethodsWe performed microRNA (miRNA) and messenger RNA (mRNA) profiling using microarray in cells treated with bile acids. Data integration of the miRNA/mRNA profiles with gene ontology (GO) analysis and bioinformatics was performed to detect potential miRNA-mRNA regulatory circuits. Transfection of gastric cancer cell lines with miRNA mimics and inhibitors was used to evaluate their effects on the expression of candidate targets and functions. Immunohistochemistry and in situhybridisation were used to detect the expression of selected miRNAs and their targets in IM tissue microarrays.ResultsWe demonstrate a bile acids-triggered pathway involving upregulation of miR-92a-1–5p and suppression of its target FOXD1 in gastric cells. We first found that miR-92a-1–5p was increased in IM tissues and induced by bile acids. Moreover, miR-92a-1–5p was found to activate CDX2 and downstream intestinal markers by targeting FOXD1/FOXJ1 axis and modulating activation of nuclear factor kappa B (NF-κB) pathway. Furthermore, these effects were found to be clinical relevant, as high miR-92a-1–5p levels were correlated with low FOXD1 levels and high CDX2 levels in IM tissues.ConclusionThese findings suggest a miR-92a-1–5p/FOXD1/NF-κB/CDX2 regulatory axis plays key roles in the generation of IM phenotype from gastric cells. Suppression of miR-92a-1–5p and restoration of FOXD1 may be a preventive approach for gastric IM in patients with bile regurgitation.
Timeline and location of recurrence following successful ablation in Barrett’s oesophagus: an international multicentre study
Authors: Sami Sarmed S , Ravindran Adharsh , Kahn Allon , Snyder Diana , Santiago Jose , Ortiz-Fernandez-Sordo Jacobo , Tan Wei Keith , Dierkhising Ross A , Crook Julia E , Heckman Michael G , Johnson Michele L , Lansing Ramona , Ragunath Krish , di Pietro Massimiliano , Wolfsen Herbert , Ramirez Francisco , Fleischer David , Wang Kenneth K , Leggett Cadman L , Katzka David A , Iyer Prasad G 
Published: January 2019

ObjectiveSurveillance interval protocols after complete remission of intestinal metaplasia (CRIM) post radiofrequency ablation (RFA) in Barrett’s oesophagus (BE) are currently empiric and not based on substantial evidence. We aimed to assess the timeline, location and patterns of recurrence following CRIM to inform these guidelines.DesignData on patients undergoing RFA for BE were obtained from prospectively maintained databases of five (three USA and two UK) tertiary referral centres. RFA was performed until CRIM was confirmed on two consecutive endoscopies.Results594 patients achieved CRIM as of 1 May 2017. 151 subjects developed recurrent BE over a median (IQR) follow-up of 2.8 (1.4–4.4) years. There was 19% cumulative recurrence risk of any BE within 2 years and an additional 49% risk over the next 8.6 years. There was no evidence of a clinically meaningful change in the recurrence hazard rate of any BE, dysplastic BE or high-grade dysplasia/cancer over the duration of follow-up, with an estimated 2% (95% CI −7% to 12%) change in recurrence rate of any BE in a doubling of follow-up time. 74% of BE recurrences developed at the gastro-oesophageal junction (GOJ) (24.1% were dysplastic) and 26% in the tubular oesophagus. The yield of random biopsies from the tubular oesophagus, in the absence of visible lesions, was 1% (BE) and 0.2% (dysplasia).ConclusionsBE recurrence risk following CRIM remained constant over time, suggesting that lengthening of follow-up intervals, at least in the first 5 years after CRIM, may not be advisable. Sampling the GOJ is critical to detecting recurrence. The requirement for random biopsies of the neosquamous epithelium in the absence of visible lesions may need to be re-evaluated.
Estimating the performance of three cardiovascular disease risk scores: the Estonian Biobank cohort study
Authors: Saar Aet , Läll Kristi , Alver Maris , Marandi Toomas , Ainla Tiia , Eha Jaan , Metspalu Andres , Fischer Krista 
Published: January 2019

BackgroundWe aim to investigate the predictive ability of PCE (Pooled Cohort Equations), QRISK2 and SCORE (Systematic COronary Risk Estimation) scoring systems for atherosclerotic cardiovascular disease (ASCVD) risk prediction in Estonia, a country with one of the highest ASCVD event rates in Europe.MethodsSeven-year risk estimates were calculated in risk score–specific subsets of the Estonian Biobank cohort. Calibration was assessed by standardised incidence ratios (SIRs) and discrimination by Harrell’s C-statistics. In addition, a head-to-head comparison of the scores was performed in the intersection of the three score-specific subcohorts.ResultsPCE, QRISK2 and SCORE risk estimates were calculated for 4356, 7191 and 3987 eligible individuals, respectively. During the 7-year follow-up, 220 hard ASCVD events (PCE outcome), 671 ASCVD events (QRISK2 outcome) and 94 ASCVD deaths (SCORE outcome) occurred among the score-specific subsets of the cohort. While PCE (SIR 1.03, 95% CI 0.90 to 1.18) and SCORE (SIR 0.99, 95% CI 0.81 to 1.21) were calibrated well for the cohort, QRISK2 underestimated the risk by 48% (SIR 0.52, 95% CI 0.48 to 0.56). In terms of discrimination, PCE (C-statistic 0.778) was inferior to QRISK2 (C-statistic 0.812) and SCORE (C-statistic 0.865). All three risk scores performed at similar level in the head-to-head comparison.ConclusionOf three widely used ASCVD risk scores, PCE and SCORE performed at acceptable level, while QRISK2 underestimated ASCVD risk markedly. These results highlight the need for evaluating the accuracy of ASCVD risk scores prior to use in high-risk populations.