bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthropometric Prediction Equations for Estimating Muscle Mass of Elderly Women
Authors: Handayani Maria Dara Novi , Sadewa Ahmad Hamim , Farmawati Arta , Rochmah Wasilah 
Published: March 2019

Muscle Mass (MM) has an important role in health and physical performance. There are many MM prediction equations, but none is formulated in Indonesia. This study aimed to develop Anthropometric Equations (AE) prediction for MM. A cross sectional study was used to formulate AE prediction through multiple regression analysis. The significance of observed differences between predicted and actual MM was tested by t test while level of agreement was assessed by Bland Altman plot. A significant correlation was found between MM and height, body mass index, calf/arm/waist circumferences, and waist hip ratio (p<0.05). Regression anal¬ysis indicated that age, height, and Mid Arm Circumference (MAC) contributed significantly to MM. The resulting equation was MM (kg) = -10.22+(-.097x age)+(0.16xheight)+(0.30xMAC). There was no significant difference between actual and predicted MM results, and both had significant correlation. These results suggest that age, AP related to MM and AE provide valid prediction of MM for healthy elderly women in Jakarta.
Circulating aryl hydrocarbon receptor-interacting protein (AIP) is independent of GH secretion
Authors: Stojanovic Marko , Wu Zida , Stiles Craig E , Miljic Dragana , Soldatovic Ivan , Pekic Sandra , Doknic Mirjana , Petakov Milan , Popovic Vera , Strasburger Christian , Korbonits Márta 
Published: March 2019

Background
Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionarily conserved and expressed widely throughout the organism. Loss-of-function AIP mutations predispose to young-onset pituitary adenomas. AIP co-localizes with growth hormone in normal and tumorous somatotroph secretory vesicles. AIP protein is detectable in circulation. We aimed to investigate possible AIP and GH co-secretion, by studying serum AIP and GH levels at baseline and after GH stimulation or suppression, in GH deficiency (GHD) and in acromegaly patients.

Subjects and methods
Insulin tolerance test (ITT) was performed in GHD patients (n = 13) and age-BMI-matched normal GH axis control patients (n = 31). Oral glucose tolerance test (OGTT) was performed in active acromegaly patients (n = 26) and age-BMI-matched normal GH axis control patients (n = 18). In-house immunometric assay was developed for measuring circulating AIP.

Results
Serum AIP levels were in the 0.1 ng/mL range independently of gender, age or BMI. Baseline AIP did not differ between GHD and non-GHD or between acromegaly and patients with no acromegaly. There was no change in peak, trough or area under the curve during OGTT or ITT. Serum AIP did not correlate with GH during ITT or OGTT.

Conclusions
Human circulating serum AIP in vivo was assessed by a novel immunometric assay. AIP levels were independent of age, sex or BMI and unaffected by hypoglycaemia or hyperglycaemia. Despite co-localization in secretory vesicles, AIP and GH did not correlate at baseline or during GH stimulation or suppression tests. A platform of reliable serum AIP measurement is established for further research of its circulatory source, role and impact.
Sobre el territorio: prácticas artísticas socialmente comprometidas
Authors: Sobrino Manzanares María Luisa 
Published: March 2019

Frente a las consideraciones tradicionales, el nuevo género de arte público supone una alteración de los planteamientos formales anteriores y de las respectivas referencias al lugar. Implicado en indagar y participar en motivaciones y situaciones sociales, se sitúa más allá de cualquier aspecto de lo que tradicionalmente se entendía como arte y, especialmente, de toda noción convencional referente a la idea de escultura pública. Nuevas propuestas que cambian de modo radical la idea de arte en el espacio urbano porque ya no pretenden ser referencia física, señalamiento o diálogo con el medio, sino un elemento de confrontación ciudadana, integrante y compartido por la comunidad en la que se asienta. Desde esta perspectiva, mi propuesta se centra, especialmente, en la obra de Carme Nogueira, una de las artistas más representativas dentro de la tendencia de un cuestionamiento crítico sobre el espacio público.
Alkoholio vartojimo įpročiai, aplinka ir pasekmės Lietuvoje
Authors: Karpuškienė Vita , Rastenienė Aušrytė , Liepuonius Arvydas 
Published: March 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Perteklinis alkoholinių gėrimų vartojimas yra labai opi Lietuvos visuomenės problema. Pasaulio svei­katos organizacija ir Europos Sąjungos komisija pateikia duomenų, kurie kelia labai didelį susirūpinimą – Lietuva yra daugiausia alkoholio vartojanti šalis. Vyriausybė priėmė įstatymo pataisas, nuo 2018 m. ir 2020 m. apribojančias prekybos alkoholiu laiką, amžių ir reklamą. Šis reguliavimas liečia visus gyventojus, neatsižvelgiant į alkoholio vartojimo elgseną. Siekiant veiksmingos alkoholio vartojimo politikos, būtina ištirti alkoholio vartojimo įpročius, aplinką ir priežastis.
Šiame straipsnyje pristatomi 2016 m. gruodžio mėnesio Vilniaus universiteto Ekonomikos fakulteto mokslininkų ir Lietuvos verslo konfederacijos atstovų atlikto tyrimo rezultatai. Tyrimo tikslas – išsiaiškinti alkoholinių gėrimų vartotojų grupes ir jų alkoholio vartojimo elgseną. Pateikiamos įžvalgos apie tris alkoholio vartojimo aspektus: 1) alkoholio vartojimo kiekį ir dažnumą; 2) vartojimo įpročius ir aplinką bei 3) vartojimo priežastis. Atliktas tyri­mas – nuolatinės alkoholio vartojimo stebėsenos modeliui sukurti skirto tyrimo pirmo etapo rezultatas. Straipsnyje gautos išvados lyginamos su kitų institucijų naujausių tyrimų rezultatais. Tyrimas parodė, kad gyventojų apklausos yra tinkamas metodas gėrimo įpročiams ir aplinkai bei motyvams atskleisti, bet juo remiantis negalima adekvačiai vertinti suvartojamo alkoholio kiekio. Nagrinėjant gyventojų alkoholio vartojimo dažnumą, matomas didelis pasis­kirstymo netolygumas. Tyrimas atskleidė, kad pusė vartojančiųjų išgeria mažiau negu ketvirtadalį (23 proc.) viso alkoholio kiekio, o 10 proc. gausiausiai vartojančių alkoholį apklaustųjų išgeria daugiau negu trečdalį (37 proc.) viso alkoholio kiekio. Keturių išskirtų grupių vartojimo įpročiai ir aplinka skiriasi, tačiau daugiausia alkoholio išgeriama uždaroje namų aplinkoje su artimaisiais, draugais, giminėmis ir bendradarbiais, t. y. dominuoja buitinis alkoholio vartojimo būdas.
Bevaikystė Lietuvoje: tendencijos, normos ir regioninė diferenciacija
Authors: Gedvilaitė-Kordušienė Margarita , Tretjakova Vaida , Ubarevičienė Rūta 
Published: March 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Paskutiniais dešimtmečiais daugelyje Europos šalių didėja bevaikių moterų skaičius. Lietuvoje, skirtingai nuo kitų Europos šalių, bevaikių moterų skaičius išlieka žemas. Šio straipsnio tikslas – išanalizuoti moterų baigtinės bevaikystės tendencijas, atskleisti moterų, gimusių 1920–1969 m., socialines ir demografines charakteristikas bei bevaikystės teritorinės diferenciacijos ypatumus. Analizei yra naudojami Europos socialinio tyrimo (2008) ir Lietu­vos gyventojų surašymo (2011) duomenys. Analizės rezultatai parodė, kad nors ES šalių kontekste bevaikių moterų skaičius Lietuvoje vertinamas kaip nedidelis, tačiau paskutinių dešimtmečių duomenys rodo gana spartų bevaikių moterų dalies didėjimą. Kultūrinių nuostatų analizė atskleidė, kad Lietuvoje vyrauja gana prieštaringos nuostatos dėl bevaikystės. Socialinių ir demografinių charakteristikų analizė atskleidė, kad ryškiausi skirtumai tarp gimdžiusių ir niekada vaikų nesusilaukusių moterų yra pagal santuokinį statusą ir išsilavinimą. Erdvinė baigtinės bevaikystės analizė parodė, kad šis demografinis procesas Lietuvoje pasižymi gana didelė teritorine diferenciacija, kuri suinten­syvėjo nuo 1940–1949-ųjų kartos.
The constructions of everyday ethics in Lithuanian family social work practices
Authors: Motieciene Roberta , Laitinen Merja , Skaffari Pia 
Published: March 2019

[full article and abstract in English]
The aim of this study was to shed light on family social work through analyzing the insights of Lithuanian social workers about the ethical questions that emerge during their daily practices. Social workers’ ethical consider­ations are analyzed in the framework of “doing ethics.” Ethics work also pays attention to the broader political and social contexts behind the processes that happen within families. Our qualitative research was carried out in three of the largest Lithuanian cities: Vilnius, Kaunas and Klaipėda. Semi-structured interviews were conducted with 25 family social workers. The research findings showed that family social workers construct ethical questions through discursive themes, such as the dignity of the client and societal inequalities – especially poverty issues and social control and support. Ethical dilemmas arise in the settings where social workers do evaluations and make decisions, and where actions require professional knowledge.
Ilgalaikė senyvo amžiaus asmenų globa Lietuvoje: visuomenės nuostatos ir paslaugų teikėjų požiūriai
Authors: Matonytė Irmina , Kazlauskaitė Rūta , Poškutė Virginija 
Published: March 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Straipsnyje, remiantis gerovės kultūros prieiga ir viešųjų vertybių vadybos idėjomis, analizuojama ir įvertinama ilgalaikės senyvo amžiaus asmenų globos ir slaugos (IGS) problematika Lietuvoje. Pradžioje apžvelgiami Lietuvos mokslininkų darbai, susiję su socialine politika ir IGS, bei apibūdinama šios srities būklė šalyje. Visuomenės nuostatos ir paslaugų teikėjų požiūriai į atsakomybę už rūpinimąsi senyvo amžiaus asmenimis bei į socialinių paslaugų plėtros poreikį IGS srityje interpretuojami kaip kompleksinė reakcija į nepatenkinamą IGS situaciją. Straipsnis baigiamas rekomendacijomis stiprinti viešųjų vertybių vadybos propaguojamus demokratinius svarstymus ir kitus instrumentus, kuriais būtų geriau atliepiama į visų suinteresuotų šalių vertybines nuostatas ir lūkesčius ir būtų geriau derinami jų interesai IGS srityje.
Social Media Influencer Marketing and Children’s Food Intake: A Randomized Trial
Authors: Coates Anna E. , Hardman Charlotte A. , Halford Jason C.G. , Christiansen Paul , Boyland Emma J. 
Published: March 2019

OBJECTIVES:
To examine the impact of social media influencer marketing of foods (healthy and unhealthy) on children’s food intake.

METHODS:
In a between-subjects design, 176 children (9–11 years, mean 10.5 ± 0.7 years) were randomly assigned to view mock Instagram profiles of 2 popular YouTube video bloggers (influencers). Profiles featured images of the influencers with unhealthy snacks (participants: n = 58), healthy snacks (n = 59), or nonfood products (n = 59). Subsequently, participants’ ad libitum intake of unhealthy snacks, healthy snacks, and overall intake (combined intake of healthy and unhealthy snacks) were measured.

RESULTS:
Children who viewed influencers with unhealthy snacks had significantly increased overall intake (448.3 kilocalories [kcals]; P = .001), and significantly increased intake of unhealthy snacks specifically (388.8 kcals; P = .001), compared with children who viewed influencers with nonfood products (357.1 and 292.2 kcals, respectively). Viewing influencers with healthy snacks did not significantly affect intake.

CONCLUSIONS:
Popular social media influencer promotion of food affects children’s food intake. Influencer marketing of unhealthy foods increased children’s immediate food intake, whereas the equivalent marketing of healthy foods had no effect. Increasing the promotion of healthy foods on social media may not be an effective strategy to encourage healthy dietary behaviors in children. More research is needed to understand the impact of digital food marketing and inform appropriate policy action.
Analysis of factors associated with the incidence of members of locomotive crews
Authors: Zhidkova E. A. , Gutor E. M. , Kalinin M. R. , Naygovzina N. B. , Gurevich K. G. 
Published: March 2019

Aim. To analyze factors that potentially influencing the incidence of members of locomotive crews.Material and methods. The survey method was used to survey 10476 members of locomotive crews. Overall 9309 individuals were included in the analysis. The study was conducted on all railways of the Russian Federation (63 subjects of the Russian Federation). The questionnaire included: the passport part, the results of medical research (blood pressure, cholesterol and blood glucose levels), questions on workrelated risk factors, risk factors for chronic non-infectious diseases, questions reflecting the subjective opinion of member on the problem.Results. The incidence of locomotive crews members is associated (p<0,05) with the place of work, the types of rolling stock and traffic. By type of traffic, the highest incidence was observed in the members of goods trains; by type of rolling stock, the lowest incidence was among engine drivers and their assistants. The number of cases of diseases with temporary disability over the past year has been associated with rank held. Persons who have experienced temporary disability, are characterized by: 1,2 times lower daily consumption of fruits and vegetables, 1,1 times higher value of BMI and waist circumference, and 1,03 higher blood cholesterol level.Conclusion. The results show that preventive programs can be effective in reducing the incidence of locomotive crews members.
Prevalence of electrocardiographic changes in Kemerovo region according to the data of the ESSE-RF study
Authors: Polikutina O. M. , Slepynina Yu. S. , Karetnikova V. N. , Mulerova T. A. , Indukaeva E. V. , Artamonova G. V. 
Published: March 2019

Aim. To study the prevalence of ECG changes associated with gender and age according to the program ESSE-RF, Kemerovo.Material and methods. The object of the study is a random sampling of male and female population aged 25-64, Kemerovo. The standard 12-leads ECG was captured in 1623 people. Coding was carried out according to the Minnesota code. The average age of the respondents was 49 years (37; 57), men, 47 years (36; 56), women, 50 years (38; 57), (p=0,004).Results. The ECGs changes were recorded in 265 people (16,3%), in 124 men (17,8%) and 141 women (15,2%) (p=0,159). Heart rhythm disturbances were revealed in 108 people (6,7%), intraventricular conduction disturbances in 147 (9%). The most frequently recorded changes in the T wave (in 11,2% of the subjects), ST segment changes take the second place (in 5,1%), the pathological Q wave was registered less frequently (in 2,5%). In men, the ECG signs of LV hypertrophy, rhythm disturbances, the pathological Q wave were more often detected. In the group of the 50-64-year-olds, the pathological Q wave, changes in ST segment and T wave, rhythm and conduction disturbances were detected significantly more often as well as the greater prevalence of risk factors of ischemic heart disease.Conclusion. Detection of ECG changes is an important stage in the formation of a risk group at the development and progression of the cardiovascular pathology.
The prognostic value of the NT-proBNP biomarkers and Fas ligand in assessing the risk of cardiotoxicity of anthracycline chemotherapy
Authors: Teplyakov A. T. , Shilov S. N. , Popova A. A. , Berezikova E. N. , Neupokoeva M. N. , Grakova E. V. , Kopeva K. V. 
Published: March 2019

Aim. To study the mechanisms, features of clinical manifestations and predicting of cardiotoxicity resulting from anthracycline chemotherapy.Material and methods. We examined 176 women with breast cancer who received anthracycline antibiotics as part of polychemotherapeutic (PCT) treatment. Patients were divided into 2 groups: with the development of cardiotoxic remodeling — group 1 (n=52) and with preserved heart function — group 2 (n=124). We conducted echocardiographic (EchoCG) tests before the start, during and after anthracycline chemotherapy. In the serum after the termination of PCT treatment, the concentrations of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and soluble Fas ligand (sFas-L) were determined.Results. Analysis of EchoCG parameters in patients after 12 months of PCT finish, showed a significant difference in the final systolic and end diastolic sizes, as well as a significant decrease in the left ventricular ejection fraction in group 1 compared with those before the start of treatment. A direct correlation was found between the end-systolic and end-diastolic volumes and inverse correlation between left ventricular ejection fraction and the resulting summary dose of doxorubicin. EchoCG changes in women of group 1 after the first course of PCT treatment were recorded in 49% of cases and 11% of cases — in group 2. The concentrations of sFas-L and NT-proBNP after PCT therapy finish in group 1 were significantly higher compared with group 2. Patients with significantly elevated NT-proBNP levels were had a high risk of heart disease developing during 12 months follow-up. A high concentration of NT-proBNP is a predictor of cardiovascular complications, which is more sensitive than EchoCG.Conclusion. Fas-associated apoptosis plays an important role in the pathogenesis of anthracycline cardiotoxicity. NT-proBNP may be an important biomarker for cardiotoxicity development, which already effective when EchoCG or clinical signs is absent.
Pathogenetic role of the autonomic nervous system in arterial hypotension cardiac remodeling in young women
Authors: Baev V. M. , Agafonova Т. Yu. 
Published: March 2019

Aim. To study the features of cardiac remodeling on condition of the autonomic nervous system (ANS) in young women with idiopathic arterial hypotension (IAH).Material and methods. A comparative analysis of the echocardiography data in women with IAH aged 18-25 years with a predominance of sympathetic (n=150) and parasympathetic (n=60) parts of the ANS was performed. The level of systolic blood pressure ≤98 mm Hg worked as the criterion of IAH. The activity of the ANS was evaluated by the I. Kérdö index.Results. It has been shown that women with IAH with sympathicotonia are characterized by a significant decrease in the structural parameters of the heart: the size of all chambers and the aortic ostium, contractile function decrease and a slower relaxation of the left ventricle (LV). Acceleration of intracardiac hemodynamics was observed: an increase in blood flow rates and pressure gradients on the mitral, tricuspid and pulmonary artery valves, an increase in the rates of early and late diastolic LV filling. Changes in early LV diastole are associated with an increase of pressure in the left atrium. We identified a restrictive type of diastolic dysfunction in women with parasympathicotonia.Conclusion. Sympathicotonia and parasympathicotonia in young women with IAH are associated with different heart remodeling variants. Cardiac hypotrophy, decrease of contractile function and impaired LV relaxation during hypotension are associated with low sympathetic activity against the background of parasympathicotonia. The restrictive type of diastolic dysfunction during hypotension is associated with parasympathicotonia. Use of cholinolytics and anticholinesterase reactivators are the potential way of correction of ANS dysfunction, IAH regression and cardiac remodeling.
Evaluation of the optimal values of cholesterol of high density lipoproteins in a cohort of men aged 40-59 with myocardial infarction (according to 30-year monitoring of the status of life)
Authors: Belov V. V. , Menshchikov A. A. 
Published: March 2019

Aim. To establish connection between the functions of 30-year survival rate and concentration of cholesterol high density lipoproteins (C-HDL) in men aged 40-59 years with a past history of a myocardial infarction (MI) and relying on the obtained data to determine the optimal level of C-HDL for the specified cohort.Material and methods. The study includes 141 patients who have had MI more than 6 months ago and observed in clinics of Metallurgical district of the city of Chelyabinsk within the third group of dispensary register. Specified MI cases refer to types 1, 2 of the Third universal definition of MI. The initial stage of study of the target group of men who have a past history of MI lasted from 03.06.1974 to 24.11.1975. Observation points were 0 and 30 years. The endpoint was death. Information about the dead established during the annual monitoring of the status of life. During the observation period 130 persons/92,2% died. Evaluation of survival was carried out according to the method of Kaplan-Meier, based on which a Cox regression model was built with the inclusion of successively higher minimum level of C-HDL, so that survival curves were significantly different. 95% confidence intervals were determined. The confidence bands of survival functions were built on the basis of on non-parametric Kolmogorov-Smirnov test.Results. The analysis of the function of 30-year survival in men aged 40-59 with past history of MI, depending on the level of HDL-C showed: the presence of statistically significant relationships between survival and levels of HDL-C. Optimal concentrations of HDL cholesterol for survival were the values of HDL-C ≥2,0 mmol/l. Statistically significant periods of survival differences are shown on survival curves at different levels of HDL-C. The possibility of prediction of survival of each patient to a certain time depending on the level HDL-C is determined. Initial levels of HDL-C determine the beginning, duration, end of periods of statistically significant survival differences on survival curves.Conclusion. The analysis of 30-year monitoring of the life status of cohort of men aged 40-59 with past history of MI showed a statistically significant dependence of survival on the initial level of HDL-C. The initial concentration of HDL-C are optimal for survival of indicated cohorts of men. HDL-C levels of 2,0-2,9 mmol/l can serve as a therapeutic target for men aged 40-59 with a past history of MI. The functions of 30-year survival in the cohort of middle-aged men who underwent MI, allow to determine the probability of survival of patients with this level of HDL-C to certain time.
Referrals to a Phase I Clinic and Trial Enrollment in the Molecular Screening Era
Authors: Tan Tira , Rheaume Michael , Wang Lisa , Chow Helen , Spreafico Anna , Hansen Aaron R. , Razak Albiruni R.A. , Siu Lillian L. , Bedard Philippe L. 
Published: March 2019

AbstractBackgroundEnrichment of patients based on molecular biomarkers is increasingly used in early phase clinical trials. Molecular profiling of patients with advanced cancers can identify specific genomic alterations to inform decisions about investigational treatment(s). Our aim was to evaluate the outcomes of new patient referrals to a large academic solid tumor phase I clinical trial program after the implementation of molecular profiling.Materials and MethodsRetrospective chart review of all new referrals to the Princess Margaret Cancer Centre (PM) phase I clinic from May 2012 to December 2014. Molecular profiling using either MALDI-TOF hotspot mutation genotyping or targeted panel DNA sequencing was performed for patients at PM or community hospitals through the institutional IMPACT/COMPACT trials.ResultsA total of 971 new patient referrals were included for this analysis. Twenty-seven percent of referrals assessed in clinic were subsequently enrolled in phase I trials. Of all new referrals, 41% had prior molecular profiling, of whom 11% (n = 42) were enrolled in genotype-matched trials. Patients with prior molecular profiling were younger, more heavily pretreated, and had more favorable Princess Margaret Hospital Index (PMHI) scores. Eastern Cooperative Oncology Group (ECOG) performance status 0–1 (p = .002), internal referrals within PM (p = .002), and PMHI (p ≤ .001) were independently associated with successful trial enrollment in multivariable analysis.ConclusionAlthough nearly half of new patients referred to a phase I clinic had prior molecular profiling, the proportion subsequently enrolled into clinical trials was low. Prior molecular profiling was not an independent predictor of clinical trial enrollment.