bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to Play Among Elite Basketball Players After Osteochondral Allograft Transplantation of Full-Thickness Cartilage Lesions
Authors: Balazs George C. , Wang Dean , Burge Alissa J. , Sinatro Alec L. , Wong Alexandra C. , Williams Riley J. 
Published: July 2018

Background: Osteochondral allograft transplantation (OCA) is a recognized option for full-thickness articular cartilage defects of the knee, especially in the setting of large lesions or those involving the subchondral bone. Previous heterogenous studies of athletes have shown a 75% to 79% rate of return to play after the procedure. Purpose: To define return-to-play rates in a cohort of elite collegiate and professional basketball players following osteochondral allograft of the knee. Study Design: Case series; Level of evidence, 4. Methods: Prospectively collected data from an institutional cartilage repair registry were retrospectively reviewed. Patients were eligible for inclusion if they were collegiate or professional basketball players at the time of surgery. Patient demographics, lesion size and location, and surgical details were collected. Postoperative magnetic resonance imaging scans were scored with the OCAMRISS system. Time to return to play and pre- versus postoperative player performance were determined with publicly available internet resources. Results: Eleven athletes (4 professional, 7 collegiate) with a total of 14 treated lesions (1 to the medial femoral condyle, 6 to the lateral femoral condyle, 5 to the trochlea, and 2 to the patella) were eligible for study inclusion. Mean lesion size was 509 mm2. All patients underwent OCA through an arthrotomy, with fresh grafts. The overall rate of return to play at the same level of competition was 80%. Median time to return to play was 14 months (range, 6-26 months). Among players with available statistics, there was no significant reduction in any performance category. Conclusion: OCA in elite basketball players results in an 80% return to previous level of competition, which is consistent with previous reports of athletes playing other sports. Osteochondral allografting is a reasonable option to consider for full-thickness cartilage lesions of the knee, even for elite jumping athletes.
Crystal chemistry of natural layered double hydroxides. 5. Single-crystal structure refinement of hydrotalcite, [Mg6Al2(OH)16](CO3)(H2O)4
Authors: Zhitova Elena S. , Krivovichev Sergey V. , Pekov Igor , Greenwell H. Christopher 
Published: July 2018

AbstractHydrotalcite, ideally [Mg6Al2(OH)16](CO3)(H2O)4, was studied in samples from Dypingdal, Snarum, Norway (3Rand 2H), Zelentsovskaya pit (2H) and Praskovie–Evgenievskaya pit (2H) (both Southern Urals, Russia), Talnakh, Siberia, Russia (3R), Khibiny, Kola, Russia (3R), and St. Lawrence, New York, USA (3Rand 2H). Two polytypes, 3Rand 2H(both ‘classical’), were confirmed on the basis of single-crystal and powder X-ray diffraction data. Their chemical composition was studied by electron-microprobe analysis, infrared spectroscopy, differential scanning calorimetry, and thermogravimetric analysis. The crystal structure of hydrotalcite-3Rwas solved by direct methods in the space groupR$ {\bar 3} $mon three crystals (two data collections at 290 K and one at 120 K). The unit-cell parameters are as follows (290/290/120 K):a= 3.0728(9)/3.0626(3)/3.0617(4),c= 23.326(9)/23.313(3)/23.203(3) Å andV= 190.7(1)/189.37(4)/188.36(4) Å3. The crystal structures were refined on the basis of 304/150/101 reflections toR1= 0.075/0.041/0.038. Hydrotalcite-2Hcrystallises in theP63/mmcspace group; unit-cell parameters for two crystals are (data collection at 290 K and 93 K):a= 3.046(1)/3.0521(9),c= 15.447(6)/15.439(4) Å,V= 124.39(8)/124.55(8) Å3. The crystal structures were refined on the basis of 160/142 reflections toR1= 0.077/0.059. This paper reports the first single-crystal structure data on hydrotalcite. Hydrotalcite distribution in Nature, diagnostic features, polytypism, interlayer topology and localisation ofM2+–M3+cations within metal hydroxide layers are discussed.
Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination
Authors: Akahori Yasushi , Wang Linan , Yoneyama Motohiro , Seo Naohiro , Okumura Satoshi , Miyahara Yoshihiro , Amaishi Yasunori , Okamoto Sachiko , Mineno Junichi , Ikeda Hiroaki , Maki Takehiro , Fujiwara Hiroshi , Akatsuka Yoshiki , Kato Takuma , Shiku Hiroshi 
Published: July 2018

Key PointsT cells expressing a CAR consisting of scFv #213 targeting WT1 peptide/HLA-A*2402 complex killed HLA-A*2402+ WT1+ tumor cell lines. The therapeutic efficacy of #213 scFv CAR-T cells was shown to be enhanced by DC vaccine in a murine xenograft model.
A phase 1 trial of vadastuximab talirine combined with hypomethylating agents in patients with CD33-positive AML
Authors: Fathi Amir T. , Erba Harry P. , Lancet Jeffrey E. , Stein Eytan M. , Ravandi Farhad , Faderl Stefan , Walter Roland B. , Advani Anjali S. , DeAngelo Daniel J. , Kovacsovics Tibor J. , Jillella Anand , Bixby Dale , Levy Moshe Y. , O’Meara Megan M. , Ho Phoenix A. , Voellinger Jenna , Stein Anthony S. 
Published: July 2018

Key Points
Vadastuximab talirine, a CD33-targeted antibody-drug conjugate, is active in combination with HMAs in frontline AML. The addition of vadastuximab talirine to HMAs led to high remission rates and protracted myelosuppression in older patients.
Development of a Medicare Health Outcomes Survey Deficit-Accumulation Frailty Index and Its Application to Older Patients With Newly Diagnosed Multiple Myeloma
Authors: Mian Hira S. , Wildes Tanya M. , Fiala Mark A. 
Published: July 2018

Purpose To develop a frailty index using the Rockwood Accumulation of Deficits approach for the Medicare Health Outcomes Survey (MHOS) and apply it in a subset of older patients with newly diagnosed multiple myeloma. Methods Data from 2,692,361 patients without cancer, > 66 years of age, in SEER-MHOS linked databases between 1998 and 2009 were analyzed. A frailty index was constructed, resulting in a 25-item scale; cutoff values were created for individuals classified as frail. This frailty index was then applied to 305 patients with newly diagnosed myeloma in the database to predict overall survival. Results In the derivation cohort of patients without cancer, the median age was 74 years and the mean frailty index was 0.23 (standard deviation, 0.17). Among patients without cancer, each 10% increase in frailty index (approximately three to four more deficits) was associated with a 40% increased risk for death (adjusted hazard ratio, 1.397; 95% CI, 1.396 to 1.399; P < .001). In the cohort of patients with newly diagnosed myeloma, the median age was 76 years and the mean frailty index was 0.28 (standard deviation, 0.17). Each 10% increase in frailty index was associated with a 16% increased risk for death (adjusted hazard ratio, 1.159; 95% CI, 1.080 to 1.244; P < .001). Fifty-three percent of patients with multiple myeloma were considered frail. The estimated median overall survival of patients considered frail was 26.8 months, compared with 43.7 months ( P = .015) for those who were not. Conclusion The MHOS-based frailty index was prognostic for patients with multiple myeloma in predicting overall survival.
Contemporarily Treated Patients With Hodgkin Lymphoma Have Childbearing Potential in Line With Matched Comparators
Authors: Weibull Caroline E. , Johansson Anna L.V. , Eloranta Sandra , Smedby Karin E. , Björkholm Magnus , Lambert Paul C. , Dickman Paul W. , Glimelius Ingrid 
Published: July 2018

Purpose With excellent cure rates for young patients with Hodgkin lymphoma (HL), there is an increasing number of female survivors of HL interested in becoming pregnant. Here, we report childbearing among contemporarily treated HL survivors in comparison with the general population. Material and Methods Using Swedish registers, 449 women (ages 18 to 40 years) diagnosed with HL between 1992 and 2009 and in remission 9 months after diagnosis were identified. Patients were age- and calendar-year–matched to 2,210 population comparators. Rates of first postdiagnosis childbirth were calculated. Hazard ratios (HRs) with 95% CIs were estimated for different follow-up periods using Cox regression. Cumulative probabilities of first childbirth were calculated in the presence of the competing risk of death or relapse. Results Twenty-two percent of relapse-free patients with HL had a child during follow-up, and first childbirth rates increased over time, from 40.2 per 1,000 person-years (1992 to 1997) to 69.7 per 1,000 person-years (2004 to 2009). For comparators, childbirth rates remained stable (70.1 per 1,000 person-years). Patients diagnosed between 2004 and 2009 had a cumulative probability of childbirth similar to comparators. Three years or more after diagnosis, no differences in childbirth rates were observed between patients and comparators, regardless of stage or treatment. Patients who received six to eight courses of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone had a lower childbirth rate than comparators during the first 3 years (HR, 0.23; 95% CI, 0.06 to 0.94), as did patients who received six to eight courses of chemotherapy and radiotherapy (HR, 0.21; 95% CI, 0.07 to 0.65). Conclusion Childbearing potential among female survivors of HL has improved over time, and childbirth rates 3 years after diagnosis in contemporarily treated patients are, in the absence of relapse, similar to those in the general population, regardless of stage and treatment.
Prospective Study of Psychosocial Outcomes of Having Contralateral Prophylactic Mastectomy Among Women With Nonhereditary Breast Cancer
Authors: Parker Patricia A. , Peterson Susan K. , Shen Yu , Bedrosian Isabelle , Black Dalliah M. , Thompson Alastair M. , Nelson Jonathan C. , DeSnyder Sarah M. , Cook Robert L. , Hunt Kelly K. , Volk Robert J. , Cantor Scott B. , Dong Wenli , Brewster Abenaa M. 
Published: July 2018

Purpose The incidence of contralateral prophylactic mastectomy (CPM) has continued to increase. We prospectively examined psychosocial outcomes before and up to 18 months after surgery in women who did or did not have CPM. Methods Women with unilateral, nonhereditary breast cancer completed questionnaires before and 1, 6, 12, and 18 months after surgery. Primary psychosocial measures were cancer worry and cancer-specific distress. Secondary measures were body image, quality of life (QOL), decisional satisfaction, and decisional regret. Results A total of 288 women (mean age, 56 years; 58% non-Hispanic white) provided questionnaire data, of whom 50 underwent CPM. Before surgery, women who subsequently received CPM had higher cancer distress ( P = .04), cancer worry ( P < .001), and body image concerns ( P < .001) than women who did not have CPM. In a multivariable repeated measures model adjusted for time, age, race/ethnicity, and stage, CPM was associated with more body image distress ( P < .001) and poorer QOL ( P = .02). There was a significant interaction between time point and CPM group for cancer worry ( Pinteraction < .001), suggesting that CPM patients had higher presurgery cancer worry, but their postsurgery worry decreased over time and was similar to the worry of patients who did not have CPM. QOL was similar between CPM groups before surgery but declined 1 month after surgery and remained lower than patients who did not have CPM after surgery ( Pinteraction = .05). Conclusion These results may facilitate informed discussions between women and their physicians regarding CPM. Fear and worry may be foremost concerns at the time surgical decisions are made, when women may not anticipate the adverse future effect of CPM on body image and QOL.
Mild Hypothyroidism in Childhood: Who, When, and How Should Be Treated?
Authors: Vigone Maria Cristina , Capalbo Donatella , Weber Giovanna , Salerno Mariacarolina 
Published: July 2018

Abstract
Mild hypothyroidism, also known as subclinical hypothyroidism (SH), is biochemically defined as serum TSH levels above the upper limit of the reference range, in the presence of normal serum concentrations of total T4 and free T4 (FT4). In the neonatal period, mild hypothyroidism can be defined by the presence of a TSH value between 6 and 20 mIU/L and normal FT4 levels. After the neonatal period, SH can be defined mild if TSH ranges between 4.5 and 10 mIU/L. The management of mild hypothyroidism in childhood is challenging. The major concern is to establish whether this condition should always be considered an expression of mild thyroid dysfunction. Indeed, the effects of untreated mild hypothyroidism are still not completely defined. In the neonatal period, concern exists about neurocognitive outcome; in children, although there is no clear evidence of alterations in growth or neurocognitive development, subtle cardiovascular abnormalities have been documented. Therefore, there is still uncertainty about the need of treatment across all ages, and the management should be based on the age of the child, the etiology, and the degree of TSH elevation, as well as on other patient factors. This review updates current evidences on diagnosis and management of mild hypothyroidism in childhood.
Rebel Coolies, Citizen Warriors, and Sworn Brothers: The Chinese Loyalty Oath and Alliance with Chile in the War of the Pacific
Authors: Tinsman Heidi 
Published: July 2018

Abstract
This essay interprets Chilean accounts of a loyalty oath by Chinese coolies to the Chilean army during the War of the Pacific against a broader social history of Chinese agrarian resistance in Peru and military experience in China. The essay argues that masculinity and labor were central to articulating divergent political agendas and defining national differences as racial differences. Chilean tales about emancipating Chinese slaves affirmed Chile's superiority over despotic Peruvians. Moreover, in stories about a Chinese oath, Chileans affirmed their civilizing mission by recognizing Chinese men as similar to themselves: brave warriors prepared to die for freedom and nation. For Chinese men, the oath was not about loyalty to Chile but loyalty to each other in an ongoing fight against bondage on Peruvian plantations. The ceremony enacted a Chinese fraternity of mutual protection and hierarchy that helped leverage Chile's invasion to replace coolie arrangements with Chinese-controlled subcontracting and free peonage.
Os acordos substitutivos e o termo de ajustamento de conduta (Lei nº 7.347/1985)
Authors: Kato Mariana Almeida 
Published: July 2018

Administrative arrangements and the adjustment of conduct agreement (Law 7.347/1985) O termo de ajustamento de conduta previsto pela Lei nº 7.347/1985 tem assumido especial importância na proteção de interesses difusos, no qual se destaca o meio ambiente. Dada ausência de tratamento normativo mais específico e da necessidade de pensar o direito administrativo para além das fronteiras tradicionalmente existentes, o tema ainda suscita dúvidas e debates quanto ao seu alcance, formação e limites. The adjustment of conduct agreement provided in Law 7.347/1985 has become especially important in the protection of diffuse interests, which environment plays a major role. Due to the absence of more specific legislation and the necessity of rethinking the administrative law beyond the traditionally existing borders, the subjects still raises doubts and discussions about its scope, formation and limits.
Partilha de produção petrolífera: reflexões sobre a nova reforma
Authors: Leite Marcelo Lauar 
Published: July 2018

Petroleum production sharing: thinking about the new reform Este ensaio se propõe a apresentar reflexões sobre o status e as perspectivas do sistema não concorrencial da “partilha de produção” após a reforma regulatória ocorrida em 2016. De fato, embora o regime jurídico ao qual se sujeitam os agentes econômicos atuantes no desenvolvimento de campos em áreas de pré-sal não seja propriamente inseguro, é também certo que ele não pode ser chamado de estável. Com efeito, apenas uma década após a descoberta do pré-sal, a tutela jurídica de sua exploração já foi alvo de três diplomas de peso: as Leis Federais nos 9.478/1997 (Lei do Petróleo — LP), 12.351/2010 (Lei da Partilha de Produção — LPP) e, mais recentemente, a 13.365/2016. Com esta última, os regimes estabelecidos na LP e na LPP ganharam novidades de relevante repercussão prática no âmbito da regulação estatal sobre a exploração do pré-sal, destacadamente no que tange ao papel da Petrobras. Neste trabalho, pretende-se contribuir com o debate a respeito das alterações vigentes ao final de 2016, relacionando, as aos sistemas concorrencial e de partilha de produção e antevendo resultados prospectivos de interesse para a indústria do petróleo e gás natural. This essay proposes to reflect on the status and prospects of the noncompetitive system of “production sharing” after the regulatory reform in 2016. In fact, although the regulation of the economic agents involved in the development of fields in pre-salt areas is not properly insecure, it is also certain that it cannot be called stable. Indeed, only a decade after the discovery of the pre-salt, the legal protection of its exploration has already been the subject of three important Federal Laws: 9.478/1997 (LP), 12.351/2010 (LPP) and, more recently, 13.365/2016. With the latter, the regimes established in the LP and in the LPP gained novelties of relevant practical repercussion in the scope of the state regulation on the exploration of the pre-salt, especially on the Petrobras function. In this paper, we intend to contribute to the debate about the legal changes made at the end of 2016, relating them to the competitive and production sharing systems and anticipating prospective results of interest to the Oil and Natural Gas Industry.
Corrupção e compliance nas empresas públicas e sociedades de economia mista: racionalidade das disposições da Lei de Empresas Estatais (Lei nº 13.303/2016)
Authors: Pinho Clóvis Alberto Bertolini de , Ribeiro Marcia Carla Pereira 
Published: July 2018

Corruption and compliance in state-owned companies: rationality of the Brazilian State Owned Companies Law (13.303/2016) A Lei nº 13.303/2016, Lei das Empresas Estatais, disciplinou diversos pontos lacunosos no direito brasileiro, nomeadamente a disciplina jurídica das sociedades de economia mista e empresas públicas. Um desses pontos é a obrigatoriedade da existência de políticas de compliance e governança corporativa para as empresas estatais, com a vedação expressa da possibilidade de acontecimentos de atos de corrupção (art. 9º, §1º, I, da Lei nº 13.303/2016). A previsão revela a particularidade com que vem sendo tratado o combate à corrupção no Brasil, principalmente no âmbito das empresas estatais. Por outro lado, a Lei nº 13.303/2016 inaugura exigências que até então eram praticadas no mercado privado e no exterior, como a constituição de Comitês de Auditoria Externos, ligados diretamente aos Conselhos de Administração das sociedades de economia mista e empresas públicas (desde que adotem o regime das sociedades anônimas). Adotando o método da análise econômica do direito, o presente artigo aborda como o fenômeno da corrupção pode afetar o funcionamento das empresas estatais brasileiras. The Brazilian Law Nº 13.303/2016 has disciplined a number of shortcomings about the State-Owned Companies in the Brazilian legal system, namely the legal discipline of mixed-capital companies and public companies. One of these points is the obligation that State-Owned Companies must have compliance and corporate governance policies, with the express prohibition of events involving acts of corruption (article 9, §1º, I, of Law 13303/2016). The Law Nº. 13.303/2016 reveals the particularity with which the fight against corruption in Brazil has been addressed. The Brazilian Law Nº. 13.303/2016 inaugurates requirements that had hitherto been practiced in the private and overseas markets, such as the constitution of External Audit Committees, directly linked to the Boards of Directors of mixed economy companies and public companies. Adopting the method of the economic analysis of law, this article shows how the phenomenon of corruption can affect the functioning of the Brazilian state-owned enterprises.
O DIREITO SOCIAL À MORADIA COMO LIMITE À INCIDÊNCIA DO ITCD SOBRE IMÓVEIS DE FAMÍLIAS CARENTES
Authors: Oliveira Fernanda Loures de , Carmona Paulo Afonso Cavichioli 
Published: July 2018

Os direitos sociais foram capitulados como direitos fundamentais pela Constituição. Nesse sentido, torna-se importante delimitar certo conteúdo de eficácia jurídica aos seus preceitos. Especificamente quanto ao direito social à moradia, embora seja bastante controvertido seu conteúdo eficacial mínimo sob a ótica prestacional, não se apresentam as mesmas dificuldades quando o assunto é seu viés negativo, incluindo sua atuação como limite à tributação. Por isso, a partir do método da revisão bibliográfica, e mediante a identificação e análise das legislações tributárias dos Estados e do Distrito Federal, pretende-se traçar a delimitação da eficácia jurídica do direito social à moradia, ao menos sob sua ótica negativa, no que concerne à incidência do imposto de transmissão causa mortis sobre imóveis de famílias carentes. Destacando-se as previsões locais mais condizentes com esse direito social, pretende-se dar a temática uma análise mais global, pautada no potencial do direito social à moradia como efetivo limite à tributação, mesmo para os casos em que não haja previsão legal específica. Nesse contexto, entende-se que o imposto sobre a transmissão causa mortis não deve incidir quando tendente à supressão do único imóvel pertencente à família carente, que atenda, em tese, os pressupostos para sua inclusão em política pública habitacional.
A descriptive study of trends in the pictures drawn by primary school learners in South Africa
Authors: Brits Hanneke 
Published: July 2018

Background: Illness, lack of vocabulary and unwillingness to discuss emotional distress may contribute to poor communication with children. Drawings may play a crucial role in enhancing communication with this patient group. Aim: This study aimed to describe the pictures drawn by primary school learners in the children's palliative care programme in Bloemfontein, South Africa, and to evaluate whether drawings can be used to assess emotional wellbeing. Methods: Drawings were assessed according to standardised human figure drawing guidelines and emotional indicator (EI) scales. Pictures were discussed with the child and compared with the clinical presence of depression or emotional discomfort. Results: A total of 29 pictures drawn by 20 children were assessed. Of the 20 participants, 18 were boys, with a mean age of 10.2 years, and 12 children were assessed as having clinical depression. Conclusions: The presence of two or more EIs, small pictures or pictures in dark colours may indicate clinical depression. Health professionals are advised not to try to interpret the picture, but to use the picture to enhance communication. Let the child explain the picture, rather than relying only on the assessment tool.