bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping transcriptome‐wide protein‐RNA interactions to elucidate RNA regulatory programs
Authors: Hannigan Molly M. , Zagore Leah L. , Licatalosi Donny D. 
Published: July 2018

BackgroundOur understanding of post‐transcriptional gene regulation has increased exponentially with the development of robust methods to define protein‐RNA interactions across the transcriptome. In this review, we highlight the evolution and successful applications of crosslinking and immunoprecipitation (CLIP) methods to interrogate protein‐RNA interactions in a transcriptome‐wide manner.ResultsHere, we survey the vast array of in vitro and in vivo approaches used to identify protein‐RNA interactions, including but not limited to electrophoretic mobility shift assays, systematic evolution of ligands by exponential enrichment (SELEX), and RIP‐seq. We particularly emphasize the advancement of CLIP technologies, and detail protocol improvements and computational tools used to analyze the output data. Importantly, we discuss how profiling protein‐RNA interactions can delineate biological functions including splicing regulation, alternative polyadenylation, cytoplasmic decay substrates, and miRNA targets.ConclusionsIn summary, this review summarizes the benefits of characterizing RNA‐protein networks to further understand the regulation of gene expression and disease pathogenesis. Our review comments on how future CLIP technologies can be adapted to address outstanding questions related to many aspects of RNA metabolism and further advance our understanding of RNA biology.
Translation, adaptation, and pilot of a guided self-help intervention to reduce psychological distress in South Sudanese refugees in Uganda
Authors: Tol W. A. , Augustinavicius J. , Carswell K. , Brown F. L. , Adaku A. , Leku M. R. , García-Moreno C. , Ventevogel P. , White R. G. , van Ommeren M. 
Published: July 2018

Background.In this period of unprecedented levels of displacement, scalable interventions are needed to address mental health concerns of forced migrants in low-resource settings. This paper describes the adaptation and piloting of a guided, multi-media, self-help intervention, Self-Help Plus (SH+), which was developed to reduce psychological distress in large groups of people affected by adversity.Methods.Using a phased approach that included community consultations, cognitive interviewing, facilitator training, pilot implementation, and a qualitative process evaluation, we adapted SH+ for use among South Sudanese refugees in a refugee settlement in northern Uganda.Results.The SH+ materials, including audio-recorded sessions and an accompanying illustrated manual, were translated into Juba Arabic. Cognitive interviewing primarily resulted in adaptations to language with some minor adaptations to content. Facilitator training and supervision led to further suggested changes to delivery methods. An uncontrolled pilot study (n = 65) identified changes in the expected direction on measures of psychological distress, functional impairment, depression, wellbeing, and psychological flexibility. The process evaluation resulted in further adaptations to intervention materials and the decision to focus future effectiveness evaluations of the intervention in its current form on South Sudanese female refugees.Conclusions.We found that this potentially scalable, guided self-help intervention could be adapted for and feasibly implemented among female South Sudanese refugees in northern Uganda. These findings lay the groundwork for a future rigorous evaluation of SH+ in this context.
The Intensity of Government–Opposition Divide as Measured through Legislative Speeches and What We Can Learn from It: Analyses of Japanese Parliamentary Debates, 1953–2013
Authors: Curini Luigi , Hino Airo , Osaka Atsushi 
Published: July 2018

AbstractThrough the analysis of legislative speeches made by prime ministers and party representatives in parliamentary sessions in Japan from 1953 to 2013, we argue that it is possible to place parties according to a dimension that captures their confrontational nature within a parliamentary democracy and its evolution over time. Using this dimension extracted via a well-known scaling algorithm (Wordfish), we develop an index of the intensity of the government–opposition divide that is directly related to the dynamics of the electoral cycle of Japanese politics. We then show how this new index greatly facilitates the investigation of two important aspects of Japanese legislative politics (the survival rate of governments and the speed of passage of cabinet bills) compared to a situation in which we focus on more traditional measures capturing the ideological position of the parties alone.
A Novel Cellulose-Preparation Method
Authors: Gillespie Richard 
Published: July 2018

AbstractThe radiocarbon (14C) dating of contaminated old wood has been seen as a challenge requiring many lengthy procedures, often using strong alkali extractions and carbon-containing solvents. Introduced here is a novel protocol called 2chlorOx, a twice-repeated sequence of alkaline hypochlorite and acidic chlorite oxidations, which is shown to work well for 14C and 13C measurements on both <5000 BP and >50,000 BP wood samples, producing results superior to those from conventional acidic chlorite or acidic dichromate oxidations. The 2chlorOx method employs only inorganic reagents, many samples can be completed in less than one day under normal laboratory conditions, and cellulose prepared in this way is usually paper-white in color.
Kinetics of trans-10, cis-12-conjugated linoleic acid transfer to plasma and milk following an abomasal bolus in lactating dairy cows
Authors: Urrutia Natalie L. , Toledo Monica , Baldin Michel , Ford Jennifer L. , Green Michael H. , Harvatine Kevin J. 
Published: July 2018

AbstractTrans-10, cis-12-conjugated linoleic acid (CLA) is a potent bioactive fatty acids (FA) that causes milk fat depression in lactating animals. FA are transferred to milk directly through chylomicrons and indirectly by recycling through other tissues. The objective of this study was to characterise the kinetics of trans-10, cis-12 CLA transfer to plasma and milk after a single bolus infusion. Five multiparous mid-lactation cows received a single abomasal bolus infusion of an enriched CLA mixture providing 15 g of trans-10, cis-12 CLA and 15 g of cis-9, trans-11 CLA over a 30-min period. Plasma concentration of trans-10, cis-12 and cis-9, trans-11 CLA peaked 2 h post-bolus, reaching 0·29 and 0·38 % of total plasma FA, respectively, and returned to pre-bolus values at 72 h post-infusion. Milk trans-10, cis-12 CLA yield and concentration peaked 14 h post-bolus (0·25 g/h) and was not detectable in milk after 86 h. Total apparent transfer of trans-10, cis-12 CLA to milk was 41 %, with 73 % transferred to milk through the direct pool (chylomicrons) and the remaining 27 % transferred through the indirect pool (tissue recycling). Compartmental modelling revealed the existence of a transient unavailable pool of trans-10, cis-12 CLA in extravascular tissues represented primarily by the mammary gland, which slowly exchanges with an available pool for secretion in milk fat and transfer to milk. In conclusion, trans-10, cis-12 CLA is predominantly transferred to milk through the direct pathway; however, how this CLA isomer is processed within the mammary gland requires further investigation.
Canada's Member-to-Member Code of Conduct on Sexual Harassment in the House of Commons: Progress or Regress?
Authors: Collier Cheryl N. , Raney Tracey 
Published: July 2018

AbstractIn 2015, the Canadian House of Commons passed a new code of conduct governing non-criminal sexual harassment between members of Parliament becoming the first of its kind in any Westminster system in the world. Using a feminist institutional and violence-against-women-in-politics approach, we assess how the code challenges, legitimizes and upholds traditionally gendered norms and institutionalized sexism within Canada's parliamentary system including parliamentary privilege, party cohesion and party discipline. Despite its novelty, we argue this code fails to enact positive gender-friendly institutional change and may do more harm than good in its efforts to curb sexual harassment.
If we accept that poor replication rates are mainstream
Authors: Alexander David M. , Moors Pieter 
Published: July 2018

AbstractWe agree with the authors' arguments to make replication mainstream but contend that the poor replication record is symptomatic of a pre-paradigmatic science. Reliable replication in psychology requires abandoning group-level p-value testing in favor of real-time predictions of behaviors, mental and brain events. We argue for an approach based on analysis of boundary conditions where measurement is closely motivated by theory.
Three strong moves to improve research and replications alike
Authors: Giner-Sorolla Roger , Amodio David M. , van Kleef Gerben A. 
Published: July 2018

AbstractWe suggest three additional improvements to replication practices. First, original research should include concrete checks on validity, encouraged by editorial standards. Second, the reasons for replicating a particular study should be more transparent and balance systematic positive reasons with selective negative ones. Third, methodological validity should also be factored into evaluating replications, with methodologically inconclusive replications not counted as non-replications.
Introducing a replication-first rule for Ph.D. projects
Authors: Kochari Arnold R. , Ostarek Markus 
Published: July 2018

AbstractZwaan et al. mention that young researchers should conduct replications as a small part of their portfolio. We extend this proposal and suggest that conducting and reporting replications should become an integral part of Ph.D. projects and be taken into account in their assessment. We discuss how this would help not only scientific advancement, but also Ph.D. candidates' careers.
What have we learned? What can we learn?
Authors: Strack Fritz , Stroebe Wolfgang 
Published: July 2018

AbstractWe advocate that replications should be an integral part of the scientific discourse and provide insights about the conditions under which an effect occurs. By themselves, mere nonreplications are not informative about the “truth” of an effect. As a consequence, the mechanistic continuation of multilab replications should be replaced by diagnostic studies providing insights about the underlying causes and mechanisms.
Median and injective metric spaces
Authors: BOWDITCH BRIAN H. 
Published: July 2018

AbstractWe describe a construction which associates to any median metric space a pseudometric satisfying the binary intersection property for closed balls. Under certain conditions, this implies that the resulting space is, in fact, an injective metric space, bilipschitz equivalent to the original metric. In the course of doing this, we derive a few other facts about median metrics, and the geometry of CAT(0) cube complexes. One motivation for the study of such metrics is that they arise as asymptotic cones of certain naturally occurring spaces.
RACE, GRIEVANCE SYSTEMS, AND PRISONERS’ PERCEPTIONS OF JUSTICE IN THREE CALIFORNIA PRISONS
Authors: Calavita Kitty , Jenness Valerie 
Published: July 2018

AbstractA large body of social science consistently documents race differences in the U.S. criminal justice system and in related perceptions of justice. It is now beyond dispute that the criminal justice system is racialized in a plethora of ways that have consequences for how people perceive justice. Another vast body of literature documents the importance of perceptions of procedural justice in people’s satisfaction with dispute management and outcomes. Informed by these two well-established literatures, we draw on original quantitative and qualitative data, including a random sample of interviews with 120 men in three California prisons, to present an empirical analysis of prisoners’ experiences with the prisoner grievance system, their level of satisfaction with the process and outcomes of that system, and their perceptions of fairness. We find an absence of race effects regarding how fairly they say they have been treated in the past by the criminal justice system and in how they assess justice in the prisoner grievance system in particular. Specifically, we find that: 1) male prisoners’ perceptions of whether the overall criminal justice system has been fair to them in the past does not vary by race in statistically significant ways; and 2) the dominance of substantive grievance outcomes over procedural elements in prisoners’ satisfaction holds regardless of racial self-identification. We explain these findings by arguing that prison may perversely level the attitudinal gap among those who are subject to this profound experience of state power.
THE ACADEMIC SWOON OVER IMPLICIT RACIAL BIAS
Authors: Russell-Brown Katheryn 
Published: July 2018

AbstractIn recent years, there has been a surge of discussion, debate, and research on the topic of implicit bias. Implicit bias has become the go-to form of racial bias that many academics, practitioners, and policy makers have identified as important and timely to study (Eberhardt et al., 2004; Levinson and Smith, 2017). Interventions to address implicit racial bias in policing have been particularly popular (Fridell 2008). Arguably, combatting implicit racial bias presents itself as a tool for protecting civil rights. This essay examines the emergence of the implicit bias paradigm as a way to address racial bias in justice system outcomes. The first part provides an overview of implicit bias, including how it is defined, how it is measured, and how it impacts the justice system. The second part examines the term “implicit bias.” This section assesses implicit bias as a social problem and considers whether the label illuminates or obscures the reality of racial bias in the criminal justice system. The discussion considers whether “implicit bias” is viewed as a more appealing approach for dealing with racial bias because it does not assign racial blame. The third part considers the contours of the relationship between implicit bias and explicit bias. The discussion highlights the interconnectedness between the two forms of racial bias. Is the implicit bias approach a signal of racial retrenchment? The final section considers how elementary and secondary education could be used as a proactive strategy for addressing implicit racial bias.
IMMIGRATION ENFORCEMENT, THE RACIALIZATION OF LEGAL STATUS, AND PERCEPTIONS OF THE POLICE
Authors: Menjívar Cecilia , Simmons William Paul , Alvord Daniel , Salerno Valdez Elizabeth 
Published: July 2018

AbstractThe immigration enforcement system today affects different subgroups of Latinos; it reaches beyond the undocumented to immigrants who hold legal statuses and even to the U.S.-born. States have enacted their own enforcement collaboration agreements with federal authorities and thus Latinos may have dissimilar experiences based on where they live. This article examines the effects of enforcement schemes on Latinos’ likelihood of reporting crimes to police and views of law enforcement. It includes documented and U.S-born Latinos to capture the spillover beyond the undocumented, and it is based on four metropolitan areas—Los Angeles, Houston, Phoenix, and Chicago—to comparatively assess the effects of various enforcement contexts. Empirically, it relies on data from a random sample survey of over 2000 Latinos conducted in 2012 in these four cities. Results show that spillover effects vary by context and legal/citizenship status: Latino immigrants with legal status are less inclined to report to the police as compared to U.S.-born Latinos in Houston, Los Angeles, and Phoenix but not in Chicago. At the other end, the spillover effect in Phoenix is so strong that it almost reaches to U.S.-born Latinos. The spillover effect identified is possible due to the close association between being Latino or Mexican and being undocumented, underscoring the racialization of legal status and of immigration enforcement today.
LIVING HISTORIES OF WHITE SUPREMACIST POLICING
Authors: Ward Geoff 
Published: July 2018

AbstractProminent U.S. police officials have advocated greater acknowledgement of the role of law enforcement in historical racial injustice, including violence, in hopes of transforming police community relations. While an encouraging development, these calls for transformative justice understate the scope of this historical and contemporary problem, neglecting the often extralegal nature of police involved violence and injustice, its array of spectacular and more subtle forms, and the layered roles of state and non-state actors in perpetrating and sanctioning White supremacist violence. Drawing on historical records of racist violence implicating police, this paper analyzes overlapping aspects of White supremacy in policing, including racist ideologies and political acts of law enforcement officers and officials, and more routine underpolicing of White supremacism by legal authorities. This backdrop of normative racist violence - physical, cultural, and structural – must inform a contemporary transformative justice agenda, including demands for explicit and robust protection from White supremacism in policing.
THE ROLE OF SCIENCE IN REDUCING RACIAL AND ETHNIC DISPARITIES IN THE JUVENILE JUSTICE SYSTEM
Authors: Rodriguez Nancy 
Published: July 2018

AbstractIn recent years, we have witnessed various efforts by the federal government to advance our justice system and improve public safety. Collaborations across justice and service agencies and research on what works in criminal justice policy have been central in criminal justice reform activities. Within the juvenile justice arena, reducing rates of victimization and delinquency, as well as implementing strategies to reduce racial and ethnic disparities remain priorities. In this essay, I discuss how research on neuroscience and brain development, and racial and ethnic disparities in justice system outcomes has informed juvenile justice policy and procedural protections for youth. I also review how school policies and practices can perpetuate racial and ethnic disparities in justice outcomes. Throughout the essay, I discuss the federal government’s role in supporting research to advance policies and practices designed to reduce these harms. I highlight the implications of these activities and ways in which data and research can continue to play a key role in realizing equal opportunity and justice for all youth, especially as they are the most vulnerable members of society.
What Explains Low Female Political Representation? Evidence from Survey Experiments in Japan
Authors: Kage Rieko , Rosenbluth Frances M. , Tanaka Seiki 
Published: July 2018

AbstractFew democratic countries have lower rates of female political representation than Japan, making it an excellent place to seek clues for female underrepresentation. We were surprised to find, based on three experimental surveys, that Japanese voters do not harbor particularly negative attitudes toward female politicians. The problem instead appears to be that women are reluctant to run for office because of socially mandated family roles. An implication of our study is that gender equality in political representation will likely founder in countries with electoral systems that require around-the-clock constituency service and legislative work, at least until citizens no longer have gendered expectations about time-consuming family obligations.
The Scientific Gaze in American Transgender Politics: Contesting the Meanings of Sex, Gender, and Gender Identity in the Bathroom Rights Cases
Authors: Wuest Jo 
Published: July 2018

AbstractIn this article, I examine how conflicts over transgender bathroom rights have ignited debates concerning the fundamental nature of transgender identity. Through an institutional and discursive analysis of North Carolina's House Bill 2 or “bathroom bill,” the Title IX case in Gloucester County School Board v. G. G., and similar federal court cases, I explore how and why forces both on the right and in the LGBTQ movement have come to rely on scientific expertise to legitimate their conceptions. As conservatives have marshaled evidence to challenge notions that transgender identity is innate, LGBTQ and transgender organizations as well as the American Civil Liberties Union have crafted a “born this way” biopolitical construction of transgender identity. I find that at their core, these conflicts are over the meanings of gender and sex in relation to transgender identity. Conservatives posit sex as biologically rooted and gender as a psychological phenomenon, whereas transgender advocates subsume gender identity into the definition of sex in arguing that constitutional and federal civil rights law must recognize gender identity as a biologically constitutive element of sex. I conclude by noting the limits of a liberal assimilationist and litigation-centric transgender politics and by exploring alternatives to this biopolitical form of transgender political identity.
Program design, implementation and performance: the case of social health insurance in India
Authors: Maurya Dayashankar , Ramesh M. 
Published: July 2018

AbstractPublished works on health insurance tend to focus on program design and its impact, neglecting the implementation process that links the two and affects outcomes. This paper examines the National Health Insurance [Rashtriya Swasthya Bima Yojana (RSBY)] in India with the objective of assessing the role of implementation structures and processes in shaping performance. The central question that the paper addresses is: why does the performance of RSBY vary across states despite similar program design? Using a comparative case study approach analyzing the program’s functioning in three states, it finds the answer in the differences in governance of implementation. The unavoidable gaps in design of health care program allow abundant scope for opportunistic behavior on the part of different stakeholders. The study finds that the performance of the program, as a result, depends on the extent to which the governance mechanism is able to contain and channel opportunistic behavior during implementation. By opening up the black box of implementation, the paper contributes to improving the performance of national health insurance in India and elsewhere.
New Seismic Evidence for Continental Collision During the Assembly of the Central Asian Orogenic Belt
Authors: Zhang Hongshuang , Li Qiusheng , Ye Zhuo , Gong Chen , Wang Xiaoran 
Published: July 2018

AbstractThe Central Asian Orogenic Belt (CAOB) was formed during the termination of the Paleo‐Asian Ocean in the Paleozoic. However, the mechanism and process of the Paleo‐Asian Ocean closure and CAOB formation remain controversial. This study presents a seismic image from the northern North China Craton to southern Mongolia derived from P and S receiver function analyses of the teleseismic records from a dense array. Our observations reveal a thicker lithosphere in the southern CAOB than in the Bohai Bay basin, which suggests that this Paleozoic orogen was less affected by the lithosphere reactivation in the eastern North China Craton during the Late Mesozoic. The imaged lithosphere‐asthenosphere boundary of the southern CAOB deepens southward and reaches a greatest depth of approximately 130 km beneath the Xilinhot fault, the northern boundary of the Solonker suture zone. The Moho displays a local uplift of approximately 5 km beneath the Linxi fault, the southern boundary of the Solonker suture zone. These features imply that the Solonker suture zone is the most plausible site of the lithosphere collision between the opposing continental margins. Additionally, a southward dipping intracrustal interface, whose depth extends from ~16 km beneath the Baolidao belt to ~20 km beneath the Linxi fault, is interpreted to be associated with the subduction of the Paleo‐Asian Oceanic slab. Additionally, the absence of lithosphere‐asthenosphere boundary phases beneath the Bainaimiao arc is inferred to be caused by the upwelling of hot mantle material after assembly of the CAOB.