bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free fatty acid profiling in marine algae extract by LC‐MS/MS and isolation as well as quantification of the ω‐3 fatty acid hexadeca‐4,7,10,13‐tetraenoic acid
Authors: Schlotterbeck Jörg , Kolb Agnes , Lämmerhofer Michael 
Published: October 2018

AbstractUndaria pinnatifida (Wakame) alga contains high amounts of hexadeca‐4Z,7Z,10Z,13Z‐tetraenoic acid which was reported to decrease the efficiency of cisplatin chemotherapeutics. To obtain a fatty acid enriched extract of this ω‐3 poly‐unsaturated fatty acid as an analytical standard, Wakame was used as source material for its extraction. A two‐step extraction protocol consisting of a liquid‐liquid extraction followed by solid‐phase extraction with 3‐aminopropyl silica in accordance to a normal‐phase elution mode was developed. An ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry method based on sequential windowed acquisition of all theoretical fragment ion mass spectra allowed a simultaneous comprehensive group selective fatty acids profiling in untargeted manner and quantitative analysis of the targeted fatty acid. Hexadeca‐4Z,7Z,10Z,13Z‐tetraenoic acid was identified using high‐resolution product ion spectra. The quantitative method was based on d5‐deuterated hexadeca‐4Z,7Z,10Z,13Z‐tetraenoic acid which was employed as surrogate calibrant. Preliminary method validation was performed by evaluating detection and quantification limits, linear range, intra‐assay and inter‐day precision. Finally, a concentration of 421.2 ± 14.9 ng/mL (4% CV) of hexadeca‐4Z,7Z,10Z,13Z‐tetraenoic acid was determined in the extract which was further used as analytical standard.
Enhanced enantioselectivity of native α‐cyclodextrins by the synergy of chiral ionic liquids in capillary electrophoresis
Authors: Zhang Qi , Zhang Jian , Xue Song , Rui Mengjie , Gao Bin , Li Ang , Bai Jiashuai , yin Zhichao , Anochie Ebubedike Mitchelle 
Published: October 2018

AbstractIn the cyclodextrins family, the native α‐cyclodextrin has almost been abandoned in capillary electrophoresis chiral separation due to its much weaker enantioselectivity compared with β‐cyclodextrin and their derivatives. In this work, several amino acid chiral ionic liquids were selected to establish synergistic enantioseparation systems with native α‐cyclodextrin. Enhanced enantioselectivities were observed in the chiral ionic liquids/α‐cyclodextrin synergistic systems compared with single α‐cyclodextrin system. A series of comparison experiments were performed to demonstrate the superiority of the synergistic systems. Primary parameters affecting the enantioseparation were systematically optimized, including the type and concentration of chiral ionic liquids, α‐cyclodextrin concentration, buffer pH, and applied voltage. Best separations of the model enantiomers were obtained in a 20 mM Tris/H3PO4 buffer at pH 2.5 containing 3% (m/v) α‐cyclodextrin and 30 mM tetramethylammonium‐l‐arginine. The results show that the α‐cyclodextrin is also worth our attention when selecting chiral selectors for capillary electrophoresis enantioseparation of specific racemic compound.
Ratiometric fluorescence nanosensors based on core‐shell structured carbon/CdTe quantum dots and surface molecularly imprinted polymers for the detection of sulfadiazine
Authors: Chen Xiaoqiang , Luan Yu , Wang Ningwei , Zhou Zhiping , Ni Xiaoni , Cao Yunfei , Zhang GuangShe , Lai Yufeng , Yang Wenming 
Published: October 2018

AbstractSulfadiazine is an environmental pollutant derived from abuse of antibiotics. Its content in environmental water is closely related to human health. Thus, a novel dual‐emission surface molecularly imprinted nanosensor is designed for the specific adsorption and detection of sulfadiazine. In the system, blue emissive carbon quantum dots wrapped with silica served as the internal reference signal for eliminating background interference, while red emissive thioglycolic acid modified CdTe quantum dots (CdTe QDs), which are low dimensional semiconductor materials by the combination of cadmium and tellurium with excellent optical properties, were encapsulated in the imprinted layer to offer recognition signal. The fluorescence of CdTe quantum dots was quenched and the fluorescence quenching degree of carbon quantum dots was inconspicuous with the increase of concentration of sulfadiazine, thereby reflecting the color change. The detection of sulfadiazine was successfully achieved in a concentration range of 0.25–20 μmol/L with detection limit of 0.042 μmol/L and nanosensors had specific recognition for sulfadiazine over its analogues. Compared to single‐emission fluorescence sensors, ratiometric fluorescence nanosensors had wider linear range and higher detection accuracy. Furthermore, the nanosensors were also successfully applied for the determination of sulfadiazine in real water and milk samples with acceptable recoveries. The study provides a feasible method for the detection of sulfadiazine and a reference for the detection of sulfonamides.
High‐speed rail and tourism in China: An urban agglomeration perspective
Authors: Li Leona S.Z. , Yang Fiona X. , Cui Chuantao 
Published: October 2018

AbstractThis work aims to provide a comprehensive analysis of the association between high‐speed rail (HSR) operation and tourist arrivals in China. A panel data of 238 prefecture‐level cities from 2003 to 2013 is analyzed, using both system generalized method of moments estimation and synthetic control methods. Nationwide, HSR implementation generates sizable tourist inflows, with stronger effect for international arrivals than for domestic ones. Furthermore, heterogeneous HSR impacts are identified through the lens of urban agglomeration: (a) Connection with core cities is quintessential in channeling international customers to the hinterlands, and (b) national cores and hinterlands benefit prominently whereas regional cores lose from HSR accessibility.
The moderating role of nationality in residents' perceptions of the impacts of tourism development in the United Arab Emirates
Authors: Hammad Nada Malalla , Ahmad Syed Zamberi , Papastathopoulos Avraam 
Published: October 2018

AbstractThe purpose of this paper is to investigate residents' perceptions of tourism impacts and whether nationality moderates the relationship between these perceptions and support for tourism development in the UAE. Using data collected from 979 respondents from the UAE, a questionnaire assessed the moderating effect of nationality on residents' perceptions of the social, cultural, environmental, and economic impacts of tourism. Social exchange theory is used as a theoretical framework for this study because it considers the heterogeneity of a community and explains the different perceptions held within it. The findings of this study show that nationality moderates the relationship between residents' perceptions of the impacts of tourism and their support for tourism development in the UAE. Specifically, nationality moderates the relationship between residents' perceptions of negative social impacts, positive cultural impacts, and negative and positive economic impacts and their support for tourism development. This study can assist tourism officials in the UAE in developing strategies that consider the diversity of a community with respect to the nationality of its residents.
Blow‐up of solution of wave equation with internal and boundary source term and non‐porous viscoelastic acoustic boundary conditions
Authors: Vicente André 
Published: October 2018

AbstractIn this paper we study the blow‐up of solution of a mixed problem associated to a nonlinear wave equation with dissipative and source term in a bounded domain of . On a boundary portion of the domain we consider a non‐porous viscoelastic acoustic boundary conditions to a non‐locally reacting boundary.
Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease
Authors: Maraki Maria I. , Yannakoulia Mary , Stamelou Maria , Stefanis Leonidas , Xiromerisiou Georgia , Kosmidis Mary H. , Dardiotis Efthimios , Hadjigeorgiou Georgios M. , Sakka Paraskevi , Anastasiou Costas A. , Simopoulou Eleni , Scarmeas Nikolaos 
Published: October 2018

ABSTRACTBackgroundThe International Parkinson and Movement Disorder Society recently introduced a methodology for probability score calculation for prodromal PD.ObjectivesTo assess the probability of prodromal PD in an older population and investigate its possible association with Mediterranean diet adherence.MethodsData from a population‐based cohort study of older adults (HEllenic Longitudinal Investigation of Aging and Diet) in Greece were used. Probability of prodromal PD was calculated according to International Parkinson and Movement Disorder Society research criteria. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate Mediterranean diet adherence score, ranging from 0 to 55, with higher scores indicating higher adherence.ResultsMedian probability of prodromal PD was 1.9%, ranging from 0.2 to 96.7% in 1,731 PD‐free individuals aged ≥ 65 (41% male). Lower probability for prodromal PD (P < 0.001) in the higher Mediterranean diet adherence groups was noted, driven mostly by nonmotor markers of prodromal PD, depression, constipation, urinary dysfunction, and daytime somnolence. Each unit increase in Mediterranean diet score was associated with a 2% decreased probability for prodromal PD (P < 0.001). Compared to participants in the lowest quartile of Mediterranean diet adherence, those in the highest quartile were associated with a ∼21% lower probability for prodromal PD.ConclusionsAdherence to the Mediterranean diet is associated with lower probability of prodromal PD in older people. Further studies are needed to elucidate the potential causality of this association, potential relation of the Mediterranean diet to delayed onset or lower incidence of PD, as well as the underlying neurobiological mechanisms. © 2018 International Parkinson and Movement Disorder Society
Structure‐based Discovery of Novel CK2α‐Binding Cyclic Peptides with Anti‐cancer Activity
Authors: Tang Shan , Zhang Na , Zhou Yue , Cortopassi Wilian A. , Jacobson Matthew P. , Zhao Li‐jiao , Zhong Ru‐gang 
Published: October 2018

AbstractProtein kinase CK2 is considered as an emerging target in cancer therapy, and recent efforts have been made to develop its ATP‐competitive inhibitors, but achieving selectivity with respect to related kinases remains challenging because of the highly conserved ATP‐binding pocket of kinases. Non‐ATP competitive inhibitors might solve this challenge; one such strategy is to identify compounds that target the CK2α/CK2β interface as CK2 holoenzyme antagonists. Here we improved the binding affinity to CK2α and cell‐based anti‐cancer activity of a CK2β‐derived cyclic peptide (Pc) by combining structure‐based computational design with experimental evaluation. By analyzing molecular dynamics simulations of Pc bound to CK2α, a series of Pc‐derived peptides was rationally designed and synthesized to evaluate their binding affinity to CK2α, as well as anti‐proliferative and pro‐apoptotic effects against HepG2 cancer cell line. One amino acid substitutions on Pc, I192F, exhibited over 10‐fold improvement in the predicted binding affinity to CK2α when compared to Pc, and a cell‐permeable version, I192F‐Tat, also demonstrated more potent anti‐proliferative and pro‐apoptotic effects against HepG2 compared to Pc. A second modification of Pc, H193W, also led to more potent cell‐based activity, despite having weaker binding affinity (∼5×) to CK2α. The discovery of the I192F and H193W peptides provides new insights for further optimization of CK2 antagonist candidates as anti‐cancer leads.
An 8 GS/s 20 GHz bandwidth master‐slave track‐and‐hold amplifier in 65 nm CMOS
Authors: Na Yunsik , Mehmood Zubair , Kang Sungbin , Jung Heechang , Seo Munkyo 
Published: October 2018

AbstractA 65 nm CMOS fully‐differential track‐and‐hold amplifier (THA) in master‐slave configuration is presented. For high‐speed operation, Cherry‐Hooper amplifier with input inductive‐peaking and switched‐source follower (SSF) circuit are used for the front‐end preamplifier and master/slave track‐and‐hold circuits, respectively. On‐wafer testing in single‐ended input/output configuration shows that the fabricated THA exhibits 20 GHz switched‐mode bandwidth and 11.9 dB conversion gain at 8 GS/s clock, with THD < −36 dB and SFDR >36 dB within the 3‐dB bandwidth, while consuming 361 mW of dc power at 2.6 V supply. This work represents the highest input bandwidth for master‐slave THA in CMOS, to the best of authors' knowledge. The chip area is 0.681 mm2 including pads (active chip area: 0.2 mm2).
Multiband microstrip MIMO antenna with CSRR loaded for GSM and LTE applications
Authors: Asadpor Loghman , Rezvani Mirhamed 
Published: October 2018

AbstractA multiband multiple‐input multiple‐output (MIMO) microstrip patch antenna using complementary split‐ring resonator (CSRR) structure is proposed for Global System for Mobile (GSM) and Long‐Term Evolution (LTE) applications. The proposed antenna consists of two radiating patches with folded microstrip lines and symmetric L‐shaped slots, which are connected together with an isolation line for reducing the coupling effect between ports. CSSRs are used to enhance the isolation and to control resonant frequencies. Radiation elements of the antenna are designed for various applications such as GSM (900 MHz) and LTE (1900/2300/2600 MHz). The proposed antenna is fed by 50 Ω CPW lines. Various parameters calculated in this antenna show a return loss and an isolation of less than −10 dB and −15 dB respectively. Moreover, the gain of 2.8dBi and the radiation efficiency of 72% have been obtained for proposed antenna. The presented antenna occupying 60 × 70 × 0.8 mm3 is implemented on an FR4 substrate.
A Novel Laser ranging method based on adaptive Kalman filter technology
Authors: Xu Xiaobin , Luo Minzhou , Pei Ronghao , Tan Zhiying 
Published: October 2018

AbstractAiming at the problem of ranging accuracy of laser radar, a laser ranging method based on adaptive Kalman filter is proposed. According to the pulsed laser ranging method and acceleration model based on Wiener process, the standard Kalman filter algorithm is established. In order to solve the problem that the statistical characteristics of laser ranging noise are inconsistent with the actual noise, the autocovariance least squares method is used to estimate the noise parameters. The Monte Carlo method is used to simulate ranging results of laser radar and evaluate the performance of different methods. The adaptive Kalman filtering algorithm using autocovariance least squares method can better adjust the noise parameters and improve the distance measurement accuracy than the traditional Kalman filter algorithm. The experiment of the actual static ranging is carried out. The experiment results show that the SD of laser ranging is reduced from 10.9 to 4.8 mm by using proposed method.
X‐band 12 W power amplifier MMIC designed with second harmonic suppression
Authors: Tao Hong‐Qi , Hong Wei , Zhang Bin 
Published: October 2018

AbstractTwo X‐band (8‐12GHz) GaAs high‐power amplifier MMICs with and without compact second harmonic suppression cells are presented in this letter. The compact second harmonic suppression cell consists of an inductor and a capacitor in series, which is equivalent to a capacitance in the fundamental frequency range while resonates at the second harmonic frequency. The power amplifier MMIC with compact second harmonic suppression cells delivers more than 12 W output power with over 33% power added efficiency and with more than 52dBc second harmonic suppression over the band of 8‐12GHz. The two chips have the same size as 3.2 × 4 mm.2
Design of high‐power W‐band push‐push oscillators using load‐pull technique
Authors: Choe Wonseok , Jeong Jinho 
Published: October 2018

AbstractNew design method of push‐push oscillators is proposed using harmonic load‐pull simulation to determine optimum load impedances at both fundamental (f0) and second harmonic frequencies (2f0). It allows high output power at 2f0 while meeting oscillation condition at f0. In addition, the compact self‐biasing source feedback is proposed using coupled line for negative resistance generation. The proposed method is applied to the design of W‐band high power push‐push oscillator using 0.15 μm GaAs pseudo‐morphic high electron mobility transistors (pHEMTs) with typical maximum oscillation frequency (fmax) of 180 GHz. The measurement shows an output power of 2.2 dBm at 92.3 GHz with a phase noise performance of −84 dBc/Hz at 1 MHz offset frequency. This result corresponds to relatively high output power at this frequency compared with reported oscillators using GaAs HEMTs with higher fmax's.
Global method for stability analysis of anchored slopes
Authors: Zhang Tan , Zheng Hong , Sun Cong 
Published: October 2018

SummaryBased on the global method, an approach is proposed to consider the effect of anchor reinforcement on slope stability, where equilibrium conditions are formulated in terms of the whole slip body. Anchor pre‐tension is assumed to be undertaken by the whole slip body instead of individual slices, causing internal force within slope more realistic. Meanwhile, the optimization model for locating the critical slip surface is of weak nonlinearity and easy to solve using the conventional optimization procedures. The effects of anchoring orientation and position are thoroughly investigated, and interesting results are obtained.
Contribution of psychiatric diagnoses to extent of opioid prescription in the first year post‐head and neck cancer diagnosis: A longitudinal study
Authors: Henry Melissa , Alias Ali , Frenkiel Saul , Richardson Keith , Hier Michael , Zeitouni Anthony , Kost Karen , Mlynarek Alex , Black Martin , MacDonald Christina , Chartier Gabrielle , Rosberger Zeev 
Published: October 2018

AbstractPurposeThe purpose of this study was to determine, within the first‐year post–head and neck cancer (HNC) diagnosis, the contribution of past and upon HNC psychiatric diagnoses (ie, substance use disorder, major depressive disorder, and anxiety disorder) to the extent (ie, cumulated dose) of opioid prescription.MethodsProspective longitudinal study of 223 consecutive adults (on 313 approached; 72% participation) newly diagnosed (<2 weeks) with a first occurrence of primary HNC, including Structured Clinical Interviews for DSM‐IV disorders, validated psychometric measures, and medical chart reviews. Opioid doses were translated into standardized morphine milligram equivalents (MME) using CDC guidelines. A model of variables was tested using multiple linear regression.ResultsFifty‐five percent (123/223) of patients received opioids at some point during the first 12 months post–HNC diagnosis, 37.7% (84/223) upon HNC diagnosis (pre‐treatment), 40.8% (91/223) during treatments, and 31.4% (70/223) post‐treatment. The multiple linear regression indicated that an AD (P = 0.04) upon HNC diagnosis in early stage contributes to cumulated MME dose in the first year post–HNC diagnosis.ConclusionThis study underlines how anxiety has important repercussions on the management of pain and illustrates the importance of screening for AD upon HNC diagnosis to allow for early prophylactic treatment and support.
Front Cover: Cover Image, Volume 74, Issue 11
Authors: Lüthi Christoph , Álvarez‐Alfageme Fernando , Romeis Jörg 
Published: October 2018

The front cover image is based on the Research Article The bean α‐amylase inhibitor αAI‐1 in genetically modified chickpea seeds does not harm parasitoid wasps by Christoph Lüthi et al., DOI: 10.1002/ps.4919. Source Image: © Dr. Christopher B. Jackson, IKELOS.
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Insect midgut structures and molecules as targets of plant‐derived protease inhibitors and lectins
Authors: Napoleão Thiago H , Albuquerque Lidiane P , Santos Nataly DL , Nova Isabella CV , Lima Thâmarah A , Paiva Patrícia MG , Pontual Emmanuel V 
Published: October 2018

AbstractThe midgut of insects is involved in digestion, osmoregulation and immunity. Although several defensive strategies are present in this organ, its organization and function may be disturbed by some insecticidal agents, including bioactive proteins like lectins and protease inhibitors (PIs) from plants. PIs interfere with digestion, leading to poor nutrient absorption and decreasing amino acid bioavailability. Intake of PIs can delay development, cause deformities and reduce fertility. Ingestion of PIs may lead to changes in the set of proteases secreted in the insect gut, but this response is often insufficient and results in aggravation of the malnutrition status. Lectins are proteins that are able to interact with glycoconjugates, including those linked to cell surfaces. Their effects on the midgut include disruption of the peritrophic matrix, brush border and secretory cell layer; induction of apoptosis and oxidative stress; interference with nutrient absorption and transport proteins; and damaging effects on symbionts. In addition, lectins can cross the intestinal barrier and reach the hemolymph. The establishment of resistant insect populations due to selective pressure resulting from massive use of a bioactive protein is an actual possibility, but this can be minimized by the multiple mode‐of‐action of these proteins, mainly the lectins. © 2018 Society of Chemical Industry
Cytomegalovirus infection in day care centres: A systematic review and meta‐analysis of prevalence of infection in children
Authors: Zheng Qing Yu , Huynh Kim T. , van Zuylen Wendy J. , Craig Maria E. , Rawlinson William D. 
Published: October 2018

SummaryMaternofetal transmission of cytomegalovirus (CMV) is the most common infectious cause of congenital malformation in developed countries. Maternal infection often results from close contact with infected children, and this may occur in day care centres (DCCs).A systematic review of observational studies was conducted to examine the prevalence of CMV infection among children attending DCCs. Meta‐analysis using the random effect model was performed for studies including controls. Sources included PubMed, EMBASE (until August 2018), and references from identified publications. Inclusion criteria were studies reporting CMV infection prevalence among childcare children aged less than 7 years of age. Controls were children without childcare exposure. CMV infection was defined as viral excretion detected by culture, polymerase chain reaction, or CMV seropositivity.Twenty‐eight publications including 8347 participants met the eligibility criteria. The pooled prevalence of CMV infection among children in childcare from all studies was 32% (95% CI 23‐41). Within case‐controlled studies, prevalence among children attending DCCs was 34% (95% CI 25‐44), whereas prevalence among those without childcare exposure was 22% (95% CI 15‐30). Meta‐analysis showed a significant association between DCC attendance and CMV infection (odds ratio 2.69, 95% CI 1.68‐4.30; heterogeneity χ2/df = 8; I2 = 84%,P < 0.00001).Attendance at DCCs is significantly associated with increased risk of childhood CMV infection. Prevention strategies to reduce risk of CMV infection of pregnant women and children should involve review of DCC exposure and consideration of preventative hygiene strategies.