bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Performance of Secondary (Step) Curing Epoxy Resin Adhesive Layer
Authors: Zhang Xiaolin , Ding Runduo , Song Xiaoxiao , Zhang Yanjun , Han Zhenzhen , Zhou Haijun , Wang Wei 
Published: December 2024

Abstract
The waterproof bonding layer is between the bridge deck and the asphalt pavement, and its performance is very important to ensure the quality of the entire pavement system In this paper, the tension strength, elongation at break and thermosetting index are used to comprehensively judge the optimal ratio of A and B components of high temperature epoxy in the adhesive layer, and the characterization of secondary (step) current performance is explored The epoxy resin adhesive layer is analyzed and verified in the 60 ° C curing environment The best construction time corresponding to different application amounts is determined On this basis, the optimal amount of waterproof adhesive layer and adhesive layer is determined, and its performance is verified The results show that the optimal ratio of high temperature epoxy resin in adaptive layer A: B is 10: 9, the curing time at 60 ° C is 5 hours, and the validity period is about 3 hours The optimal amount of adhesive layer between mixture layers is about 0.60 kg/m2, and the optimal amount of adhesive layer between steel plate and mixture is about 0.42 kg/m2 The adaptive layer has good low temperature crack resistance and can be applied to low temperature areas in the north
The optimal shape of the nozzle for drying food grains
Authors: Akhunbaev A A , Khusanboev M A , Muminov J A , Sh Khasanova G , Khakimov A A , Ergashev N A 
Published: December 2024

Abstract
This article analyzes the optimal shape of a two-segment nozzle of a drum machine for drying food grains. The loading and unloading of the nozzle at any angle between the nozzle segments are investigated using a geometric model. Equations were proposed for the maximum volume carried by the nozzle, the maximum angle of incidence and the average height of the material drop.
Enhancing energy system efficiency through power flow redistribution and storage solutions
Authors: Sh Gaipov T , Xalilov A S , Murodov B X 
Published: December 2024

Abstract
Today, new innovative technologies are widely used in all fields. The energy sector is certainly not an exception, especially in matters of efficient storage and use of electricity. There are many scientific developments in this field. Some of them are at the stage of theoretical development, while others are already in the form of working prototypes. Energy storage technologies store the excess power that occurs in the system when the consumption of electricity is at a minimum, and transmits the stored electricity to the system in the modes of maximum consumption. These technologies not only ensure the continuity of electricity, but also guarantee the energy security of the system. It can quickly provide the system with the necessary power even in various emergency situations that may occur at power stations. It also allows to adjust generation schedules of electricity produced by renewable energy sources that change dramatically due to weather. Energy storage systems are also useful for consumers - through them it will be possible to maintain stable electricity prices within the general network or to ensure individual flexibility and independence of consumption in households.
Justification of parameters and operating modes of a screw feed chopper for livestock farms
Authors: Jumatov Y , Savutov R 
Published: December 2024

Abstract
The focus of the research is on developing a new grinder design that uses less energy and metal, starting from a theoretical perspective. The study looks into how the screw cutter system’s quantitative and qualitative indicators relate to geometric factors and speed modes of operation. Only by decreasing the average cut length, or by speeding up the screw knife’s spin, can the degree of stem chopping be increased. According to the knife’s rotation speed, the experiment displays the average slice lengths and the associated productivity of the screw cutting pair. In order to comply with zootechnical criteria, the following modes should be used: n = 400-450 rpm (lav = 5,5-4 cm) with an inclined feed angle of β = 450, and n = 550-650 rpm (lav = 8-4,5 cm) with vertical loading. The productivity of the cutting pair sharply decreases as the knife’s rotation frequency increases. The aforementioned numerical examples demonstrate good agreement with the experimental results and were chosen in accordance with the characteristics of the experimental setup.
Improving the method of calculating the water balance of the Khan canal
Authors: Akhmedkhodjaeva I , Yuldasheva H , Apakhodjaeva T , Sattorov A , Melikuziyev S 
Published: December 2024

Abstract
In this article, the Morgunenkov (Khan) canal in the Chirchik-Ohangaron Basin Management for Irrigation Systems area was selected. This canal is one of the more important canal in Tashkent region because it supplies water to irrigation fields in the Urta Chirchik, Buka and Akkurgan districts of the region. In this paper the technical condition of the canal and its hydrotechnical facilities was studied. The received data was entered into the database of the processed program and the efficiency of the canal was determined. The program helps to quickly and easily identify defects that cause water wastage. This is the reason for increasing the hydraulic efficiency of the canal. In addition, the developed computer program allows for the correct distribution of water resources of the Morgunenkov (Khan) canal, taking into account the demand for water in the entire system, to prevent water shortages in the downstream areas of the canal. The benefit from the practical application of the program will be at the expense of improving the efficiency of water resources management.
Intelligent system for measuring and monitoring water levels
Authors: Djalilov A , Tasheva U , Allenova I , Umarov Sh , Yuldashev M 
Published: December 2024

Abstract
Measuring and controlling water levels at water management facilities is one of the important tasks. In this research work, we, the authors, have studied the available means of measuring water level. Some of their drawbacks were brought to light throughout the investigation. For instance, if you take a water level control gauge, you have to keep an eye on it all the time, and automation is challenging. These water level measurement devices are not up to date with modern standards. At present, there is a need for systems for continuous monitoring of water resources, collection of necessary information and, if necessary, delivery of processed information to the user or decision-making in complex situations. Taking this into account, it was aimed to develop an intelligent system for measuring and controlling the water level that meets the requirements of the time. As the basis of the intelligent system, the JSN SR-04T ultrasound sensor, which is resistant to various aggressive conditions and has high measurement accuracy, and the Arduino Nano board were taken. This intelligent system was tested at the facility and the developed system performed all tasks reliably and qualitatively.
Bedrock characterization and geochemical evolution of whole-rock weathering profile at GAG Ni laterite deposit, Southwest Papua, Indonesia
Authors: Sari D V , Wibowo G S , Nurdiyansyah A 
Published: December 2024

Abstract
A series of laboratory analyses were conducted to investigate the correlation of petrography analyses of a bedrock coupled with microscope observation and X-Ray Diffraction (XRD) then compared with distribution of geochemical elements of whole-rock weathering profile by X-Ray Fluorescence (XRF). The microscope identification revealed that the bedrock was marked by the appearance of pyroxene predominantly surrounding olivine and serpentine, then magnetite, while XRD clarified that the bedrock was predominantly contained by a number of serpentine (lizardite), then pyroxene (enstatite), and magnetite. The geochemical evolution by bulk major-minor elements geochemistry as well as gain and losses of elements (τ) and compared with the equation from the ultramafic index alteration (UMIA) revealed that Fe2O3, NiO, Al2O3, CoO, Cr2O3 and MnO contents in the bedrock were 7.18wt%, 0.23 wt%, 1.23wt%, 0.01wt%, 0.35wt%, and 0.11wt%, respectively, then strongly increased towards the transition zone to 35.89wt%, 2.04wt%, 9.01wt%, 0.10wt%, 1.87wt%, and 0.51wt%, respectively. SiO2 and MgO revealed an inverted trend where it enriched in the bedrock then extremely decreased limonite layer with SiO2 (τ = ~ -0.92) and MgO (τ = ~ -0.99). The highest value of UMIA as well as consequently the highest degree of chemical weathering in this study was located in the upper limonite with a value of 63.87.
Co-disposal as an alternative method for waste rock and tailings management–a review of geochemical aspects
Authors: Deni M C N , Afandi K , Sinamo B , Satriawan A 
Published: December 2024

Abstract
Gold mining and processing activities produce at least two materials with adverse impacts on the environment: waste rock and tailings. Waste rock is generally disposed of in a waste rock dump (WRD) or in-pit backfill, while tailings are disposed to facilities such as landfill, tailings dam, or in-pit backfill. This separation is a common practice that requires a large area and specific technical considerations of respective materials and locations. Geochemically, waste rock can be potentially acid forming (PAF) and produce acid mine drainage, while tailings geotechnically have low stability due to the very fine particles. Combining these two materials in one placement location, known as co-disposal, is expected to benefits the geochemical and geotechnical aspects. The present research aims to design a geochemically-safe co-disposal of waste rock and tailings. Field kinetic geochemical tests were carried out using a 200-liter barrel in an open space area with different co-disposal compositions and treatments to identify the leachate and surface water quality. The results show that co-disposal with a 2:1 ratio of waste rock to tailings composition with the addition of lime sand of 15 kg/ton of tailings and compaction process gives the best results on leachate water quality under the natural condition during the test. This series of tests concluded to determine geochemical factors in co-disposal quality, namely pH value of tailings, lime dosage, the quality and exposure period of the waste rock, and the compaction process of the co-disposal layers.
The effectiveness of fly ash and fly ash-cement mixtures as stabilizing materials for high plasticity clay
Authors: Pujiastuti H , Fitrayudha A , Adiansyah J , Ubaidillah A S , Winarti D , Wahyuningsih T , Efendy A , Fariyadin A , Isfanari  , Pascanawati M S , Muttaqin A , Ilmi M K , Samengasbumi R P , Sambesa A R , Rizki R , Fawaid M 
Published: December 2024

Abstract
The increasing activity of burning coal as fuel for Steam Power Plants (PLTU) will increase the amount of fly ash waste, urging the industry to maximize waste utilizations as, for instance, a stabilizing material for high plasticity clay. This research examined the effectiveness of clay + fly ash and clay + fly ash + cement stabilization in increasing the strength of road subgrade. The results showed that fly ash and fly ash + cement improved clay properties, demonstrated by the value of unsoaked CBR (5.78%) and soaked CBR (3.11%) of unstabilized clay. Clay + 20% fly ash yielded optimum CBR value (23,13%), and stabilizing clay subgrade on a 50-meter section using 20% fly ash at a cost of IDR 18,329,675. The mix of 40% fly ash + 15% cement yielded optimal CBR value (42.70%) at a cost of IDR 18,359,435.00. The evaluation of soil properties and cost analysis, shows that the most efficient mixture variation is 40% fly ash and 15% cement for clay stabilization.
G‐protein‐coupled receptor 41 in cardiomyocytes: Effect of butyrate on intracellular Ca2+ and sarcomere shortening
Authors: Yao Youxiu , Yang Xiaomei , Moore Brittni N. , Zhu Tianyue , Lester Laeben , Johns Roger A. , Pluznick Jennifer L. , Gao Wei Dong 
Published: December 2024

AbstractG‐protein‐coupled receptor 41 (GPR41) is a Gαi‐coupled receptor activated by short‐chain fatty acids (SCFAs). Here, we tested that GPR41 is also expressed in cardiomyocytes and exerts a direct negative inotropic effect when activated by SCFA butyrate. Primary cardiomyocytes were isolated from wild‐type (WT) and GPR41 knockout (GPR41−/−) adult mice and intracellular Ca2+ concentration and cell shortening were measured using the IonOptix system. RNA localization (RNAScope), quantitative real‐time polymerase chain reaction (qRT‐PCR), immunofluorescence staining, and western blot were used to examine the expression of GPR41 in adult primary cardiomyocytes of WT and GPR41−/− mice. The effect of butyrate on shortening and intracellular Ca2+ transient via GPR41 was also tested in cardiomyocytes. We demonstrated for the first time the presence of GPR41s on cardiomyocytes. Butyrate dose‐dependently decreased cell shortening and the amplitude of intracellular Ca2+ transients in cardiomyocytes from WT but not GPR41−/− mice. In WT cardiomyocytes, butyrate decreased caffeine‐mediated amplitudes of intracellular Ca2+ transients from the sarcoplasmic reticulum (SR). Moreover, the inhibitory effects of butyrate on cell shortening and intracellular Ca2+ were pertussis toxin (PTX)‐sensitive. Finally, butyrate decreased the activity of sarcoendoplasmic reticulum Ca2+‐ATPase (SERCA) and cellular 3′‐5′‐cyclic adenosine monophosphate (cAMP) content. In conclusion, GPR41 is expressed on cardiomyocytes. Butyrate, a known GPR41 agonist, reduces cardiomyocyte shortening and intracellular Ca2+ transient via decreasing Ca2+ content in the SR by inhibiting SERCA activity in a PTX‐dependent manner. These findings establish that GPR41 is directly activated by SCFAs to decrease contraction and intracellular Ca2+ transient, highlighting the potential inhibitory role of GPR41 in cardiomyocytes.
Macrophage extracellular traps are induced by Mycoplasma bovis in bovine macrophages through NADPH oxidase/ROS‐dependent manner and their antibacterial efficacy
Authors: Baz Ahmed Adel , Chen Shengli , Hao Huafang , Jin Xiangrui , Lan Shimei , Li Zhangcheng , Jin Shanyu , Zhang Yifan , Chu Yuefeng 
Published: December 2024

AbstractMycoplasma bovis has emerged as a significant pathogen in cattle, leading to considerable economic losses in the cattle industry. It is associated with various clinical syndromes, including pneumoniae, mastitis, and arthritis. The innate immune response, particularly macrophages, plays a crucial role in combating infections caused by such pathogens. The release of macrophage extracellular traps (METs) represents a novel defense mechanism employed by macrophages; however, the impact of M. bovis on the formation of METs in bovine macrophages remains unknown. Therefore, the primary objective of this study is to investigate the mechanism by which M. bovis affects the formation of bovine METs and to evaluate their bactericidal efficacy. Our findings revealed that the bovine macrophage cell lines released DNA fibrils that colocalized with histones and cellular proteins in response to M. bovis infection, as visualized by confocal and scanning electron microscopy. Moreover, the formation of METs was found to depend on NADPH oxidase, which is crucial for reactive oxygen species generation. Importantly, the formation of METs led to cell lysis in response to M. bovis infection, as indicated by the release of lactate dehydrogenase, and this process was found to be independent of apoptosis and pyroptosis. Moreover, the release of METs in response to M. bovis infection was effective in both killing and restricting its growth. Overall, our study first described how METs were produced in bovine macrophages that responded to M. bovis and demonstrated their significant function in bacterial killing, which is helpful to improve our understanding of the host's immune defense against this pathogen.
Pediatric Lateral Condyle Fractures With Elbow Dislocation: Revisiting the Song Classification of the Most Severe Injuries
Authors: Campbell Leigh , Baker Courtney E. , Rees Andrew B. , Johnson Samuel R. , Schultz Jacob D. , Wollenman Lucas C. , Sborov Katherine D. , Hysong Alexander A. , Louer Craig R. , Lempert Nathaniel L. , Moore-Lotridge Stephanie N. , Schoenecker Jonathan G. 
Published: December 2024

Introduction:
Lateral condyle fractures are the second most common pediatric elbow fracture and are at risk for malunion, nonunion or avascular necrosis. The Song or Jakob classification guides management and risk of complications. However, many lateral condyle fractures have accompanying bony or soft tissue injuries, including elbow dislocations, which are not represented in the current Song or Jakob classification systems. Little is known about the incidence and outcomes of these more complex injuries. The purpose of this study was to describe the largest known case series of these injuries and characterize the incidence and outcomes.

Methods:
Injury, presentation, treatment, and outcome data were retrospectively gathered on pediatric elbow fractures at a single center from November 2007 to October 2017.

Results:
Of 4607 pediatric elbow fractures, 492 were lateral condyle fractures, with 30 cases (6.1%) presenting with concomitant elbow dislocation. Predominantly affecting males (76.7%) with a median age of 6.9 years, these injuries often resulted from intermediate energy mechanisms. High rates of coincident neurovascular deficits (23%), skin tenting (13.3%), and polytrauma (13.3%) were observed. All cases were treated surgically, primarily within 24 hours, with no instances of AVN, nonunion, or fixation failure reported. Across the cohort, there were 2 (6.7%) pin tract infections, 2 cases required return to the operating room, and 12 (40.0)% patients requiring outpatient physical therapy for elbow stiffness.

Conclusions:
Lateral condyle fractures with concomitant ulnohumeral dislocation are distinct and unstable injuries requiring prompt inpatient treatment. Current classification systems do not adequately address this fracture-dislocation combination, risking underdiagnosis and potentially delayed reduction of a dislocated elbow. We propose adding a “Song 6” or “Jakob 4” category to existing classifications to ensure these injuries are properly identified and managed. This amendment will improve clinical awareness, facilitate timely intervention, and optimize outcomes for pediatric patients with these complex fractures.

Level of Evidence:
IV
Comparison of treatment regimens for unresectable stage III epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer
Authors: Dai Xin , Xu Qian , Sheng Lei , Zhang Xue , Huang Miao , Li Song , Huang Kai , Chu Jiahui , Wang Jian , Li Jisheng , Liu Yanguo , Zhou Jianyuan , Nie Shulun , Liu Lian 
Published: December 2024

Abstract

Background:
Durvalumab after chemoradiotherapy (CRT) failed to bring survival benefits to patients with epidermal growth factor receptor (EGFR) mutations in PACIFIC study ( evaluating durvalumab in patients with stage III, unresectable NSCLC who did not have disease progression after concurrent chemoradiotherapy). We aimed to explore whether locally advanced inoperable patients with EGFR mutations benefit from tyrosine kinase inhibitors (TKIs) and the optimal treatment regimen.

Methods:
We screened the PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases from January 1, 2000 to December 31, 2022 and performed a meta-analysis based on a Bayesian framework, with progression-free survival (PFS) and overall survival (OS) as the primary endpoints.

Results:
A total of 1156 patients were identified in 16 studies that included 6 treatment measures, including CRT, CRT followed by durvalumab (CRT-Durva), TKI monotherapy, radiotherapy combined with TKI (RT-TKI), CRT combined with TKI (CRT-TKI), and TKI combined with durvalumab (TKI-Durva). The PFS after the TKI-containing treatments was significantly longer than after the TKI-free treatments (hazard ratio [HR] = 0.37, 95% confidence interval [CI], 0.20–0.66). The PFS of TKI monotherapy was significantly longer than CRT (HR = 0.66, 95% CI, 0.50–0.87) but shorter than RT-TKI (HR = 1.78, 95% CI, 1.17–2.67). Furthermore, the PFS of RT-TKI or CRT-TKI were both significantly longer than that of CRT or CRT-Durva. RT-TKI ranked first in the Bayesian ranking, with the longest OS (60.8 months, 95% CI = 37.2–84.3 months) and the longest PFS (21.5 months, 95% CI, 15.4–27.5 months) in integrated analysis.

Conclusions:
For unresectable stage III EGFR mutant NSCLC, RT and TKI are both essential. Based on the current evidence, RT-TKI brings the best survival advantage, while CRT-TKI needs further estimation. Large randomized clinical trials are urgently needed to explore the appropriate application sequences of TKI, radiotherapy, and chemotherapy.

Registration:
PROSPERO; https://www.crd.york.ac.uk/PROSPERO/; No. CRD42022298490.
Enhanced hepatitis B virus–specific immunity by combining neutralizing antibody therapy and DNA vaccination in a murine model of chronic hepatitis B virus infection
Authors: Beretta Maxime , Vesin Benjamin , Wei Yu , Planchais Cyril , Rosenbaum Pierre , Ait-Goughoulte Malika , Pelletier Nadège , Hardy David , Mouquet Hugo , Bourgine Maryline 
Published: December 2024

Background and Aims:
Successful treatment of chronic HBV infection remains a great challenge due to the difficulty in inducing efficient immune responses. Here, we investigated the therapeutic potential of DNA vaccination combined with a potent HBV broadly neutralizing antibody targeting the small surface viral antigen.

Approach and Results:
C57BL/6 mice were transduced with adeno-associated virus-HBV and were treated twice a week with HBV broadly neutralizing antibodies for 5 weeks. A DNA-based vaccine encoding the HBV core, envelope, and polymerase proteins was administered once to mice 3 weeks after initiating antibody therapy. The antiviral effects and antigen-specific immune responses were evaluated before and for 8 weeks after therapeutic vaccination. Vaccine administration with or without antibody treatment induced the development of functional HBV-specific CD8+ T cells and envelope-specific resident memory T cells in the liver. The combination of antibody treatment and DNA vaccination enhanced the recruitment of B and CD8+ T lymphocytes into the liver of HBV-carrier mice 2 weeks after vaccination. However, although still detectable 2 months after vaccination, HBV-specific CD8+ T cells showed an exhausted phenotype, suggesting that they are dysfunctional. In contrast, more effective control of antigenemia was observed following combination therapy, which was associated with the presence of HBs-specific memory B cells.

Conclusions:
Although the combination therapy did not result in a functional cure, our findings indicate it produced additive effects on the development of HBV-specific T cells in the liver immediately following treatment, offering a better insight into the mechanisms underlying hepatic tolerance.