bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of docetaxel in high-volume hormone-sensitive metastatic prostate cancer
Authors: Beca Jaclyn , Majeed Habeeb , Chan Kelvin K.W. , Hotte Sebastian J. , Loblaw Andrew , Hoch Jeffrey S. 
Published: April 2019

Introduction: Three pivotal trials have considered the addition of docetaxel (D) chemotherapy to conventional androgen-deprivation therapy (ADT) for the treatment of metastatic hormone-sensitive prostate cancer (HSPC). While an initial small trial was inconclusive, two larger trials demonstrated significant clinical benefit, including pronounced survival benefits (added 17 months) among patients with high-volume metastatic disease. Given the evolving clinical evidence, the cost-effectiveness of this approach warrants exploration.
Methods: The cost-effectiveness of six cycles of ADT+D compared to ADT alone to treat patients with high-volume metastatic HSPC was assessed from a Canadian public payer perspective. We included three health states: HSPC, metastatic castration-resistant prostate cancer (CRPC), and death. Survival data were obtained from the CHAARTED trial, which reported outcomes specifically for high-volume disease. We used Ontario costs data and utilities from the literature.
Results: In the base case analysis, ADT+D cost an additional $25 757 and produced an extra 1.06 quality-adjusted life years (QALYs), resulting in an incremental cost-effectiveness ratio (ICER) of $24 226/QALY gained. Results from one-way sensitivity analysis across wide ranges of estimates and a range of scenarios, including an alternate model structure, produced ICERs below $35 000/QALY gained in all cases.
Conclusions: The use of D with ADT in high-volume metastatic HSPC appears to be an economically attractive treatment approach. The findings were consistent with other studies and robust in sensitivity analysis across a variety of scenarios.
Optimization of bending durability of Ti-ZnO thin films on flexible glass substrates with highly enhanced optoelectronic characteristics by atomic layer deposition
Authors: Lee Woo-Jae , Bera Susanta , Song Pung Kuen , Lee Jung Woo , Dai Wei , Kim Hyun Chang , Kim Chang Su , Kwon Se-Hun 
Published: April 2019

Abstract
Highly conducting, optically transparent and highly bending-durable Ti-doped ZnO thin film (Ti-ZnO) on flexible Willow GlassTM via atomic layer deposition is reported. The influence of the deposited film’s thickness (from 10 to 50 nm) on its microstructures, mechanical flexibility, and electrical and optical properties was investigated systematically. The results showed that the Ti-ZnO films were converted from non-crystalline structures to nanocomposite structures with increasing film thickness. The film having 40 nm thickness with enhanced optical and electrical properties showed the best figure of merit among all the films. The changes in fracture and resistivity of the films, depending on the bending cycles, showed that the films with thicknesses of 30 and 40 nm exhibited superior flexible stability. Thus, 40 nm Ti-ZnO thin film on flexible Willow GlassTM would be the best sample for efficient optical, electrical and bending properties for flexible device applications.
Evolution and Emerging Trends in HFT Research
Authors: Liu Wenqing , Chao Daniel Yuh , Lee Mike Y. J. , Chen Tingyu 
Published: April 2019

Aims: In this paper, we try to study the evolution and emerging trends of High Frequency Trading (HFT) research by examining papers published in the Web of Science (WOS) between 1993 and 2017.
Study Design: A total of 241 papers were included, and 1876 keywords from these articles were extracted and analyzed.
Place and Duration of Study: For tracing the dynamic changes of the HFT Research, the whole 24 year was further separated three consecutive periods: 1993-2002, 2003-2012, and 2013-2017.
Methodology: The Ucinet is adopted to get keywords network, or knowledge network, to study the relationship of each research theme. NetDraw was applied to visualize network. We used social network analysis (SNA) technique to reveal patterns and trends in the research by measuring the association strength of terms representative of relevant publications produced in HFT field.
Results: Results indicate that HFT research has been strongly influenced by “market”, “prices”, “finance”, “liquidity”, “statistics”, “financial markets”, “stock”, “stochastic”, “model” and “trades” as shown in Table 1, which represent some established research themes. They are major focuses and the bridges connecting to other research themes in HFT. The detailed analysis in results and discussion provides an overview of evolution and emerging trends in HFT Research.
Conclusion: It concludes that market performance related keywords, which represent some established research themes, have become the major focus in HFT research. It also changes rapidly to embrace new themes. Especially, this research may make contribution to enlarge research method in that there is no SNA research in HFT research before.
Gene Clone and Bioinformatics Analysis of Subtilisin-Like Protease in Cucumis sativus
Authors: Wang Xue , Yu Guangchao , Wang Xiangyu , Lv Chunmao 
Published: April 2019

Background: Cucumber target leaf spot (TLS), caused by Corynespora cassiicola (C. Cassiicola), is a serious disease in cucumber (Cucumis sativus) production worldwide. Therefore, cultivating new varieties of TLS resistance of C. sativus is an important goal of cucumber breeding. Previous studies have shown that subtilisin-like protease (SUBP) plays an important role in response to C. Cassiicola infection in resistant plants.
Objective: In this study, the full-length cDNA of the CsSUBP gene was cloned, and the prokaryotic expression vector was successfully constructed in order to study the effects of subtilisin. Futhermore, vital clues regarding CsSUBP gene involved in TLS resistance of C. sativus are gained from the bioinformatics assay.
Method: The CsSUBP gene was identified by sequencing with the intermediate vector pMD18 by designing specific primers and PCR amplification techniques. The prokaryotic expression vector pET30a-CsSUBP was further constructed and identified by colony PCR and EcoR V and SalⅠ double digestion.
Result: The primary structure of CsSUBP was predicted and analyzed by bioinformatics analysis. The results showed that CsSUBP was weakly acidic protein, N-terminal signal peptide region, including a Inhibitor_I9 domain domain.
Conclusion: The pET30a-CsSUBP prokaryotic expression vector was constructed successfully. This study is convenient for the study of prokaryotic expression and its kinase activity.
Depression and Suicide: The Need for Awareness of Signs of Suicidal Cognitions and Lethality
Authors: Shaughnessy Michael F. , Johnson Aaron 
Published: April 2019

Although suicide is often talked about in vague, general nebulous terms, there is little in the literature that prepares clinicians and mental health workers and counselor to the subtle signs that a person may be contemplating suicide. This paper attempts to partially fill this void.
Correlation of Features of Allergic Rhinitis and Allergic Conjunctivitis with Treatment Modalities
Authors: Aremu Shuaib Kayode , Ibrahim Tayo , Ibrahim Azeez Oyemomi , Ajoke Popoola Tomilayo 
Published: April 2019

Introduction: Allergic Rhinitis (AR) is a chronic, symptomatic allergic disorder of the nose that is usually caused by IgE-mediated inflammatory response following exposure to an allergen. The allergen could be in the form of dust, pollen, flower, animal dander, mold, cold, food allergens or insect. Clinically, AR occurs when there are recurrent nasal symptoms which are reversible either spontaneously or with medication in the preceding one year. Such symptoms include at least two of the following; excessive sneezing, running nose, nasal itching, nasal discharge, nasal congestion or obstruction.
Previous studies have linked AR to be co-existed with another form of allergic disorders including AC, Atopic dermatitis and Allergic Asthma.
This study is aimed at assessing the feature of AR patients with coexistent AC as well as evaluating the effectiveness of the treatments offered to them.
Objectives: The study was aimed at finding the correlation between the nasal and eye features in a patient who has co-existing allergic rhinitis and allergic conjunctivitis.
Methodology: This was a cross-sectional descriptive study conducted between August 2018 and November 2019 among 38 patients who presented to ENT and Ophthalmology departments of Federal Teaching Hospital Ido-Ekiti, Ekiti State, Southwestern Nigeria and was diagnosed with both allergic rhinitis and allergic conjunctivitis. Relevant data obtained were analyzed using SPSS version 20. P ≤ 0.05 was taken as significant.
Results: The patients’ age range between 8 and 81 years with a median age of 33 years. The majority were less than 45 years (63.2%) with the male to female ratio of almost. Eye pain, itching, and redness account for 97.4% of all the eye features, while the presence of Cobblestone-like papillae is the least and accounted for 5%. Nasal itching (92.1%) was the commonest nasal symptom. Sleep disturbance was found to be the most common among those with eye itching (29.7%).
Conclusion: This research was conducted to correlate the features of allergic rhinitis with those of conjunctivitis and common management and preventive measures offered to the patients seen in our clinics. The majority of the patients were less than 45 years with almost equal sex ratio. Eye pain, itching, and redness account for the majority of all the eye features, while the presence of Cobblestone-like papillae is the least eye feature. Nasal itching was the commonest nasal symptom and this was seen in the majority of the patients with eye symptoms.
Efficacy of 2,4-D Choline as Influenced by Weed Size in the Texas High Plains
Authors: Manuchehri Misha R. , Dotray Peter A. , Keeling J. Wayne 
Published: April 2019

Aim: Postemergence timing trials based on weed size were conducted near Lubbock, TX to assess the effectiveness of 2,4-D choline + glyphosate on control of Palmer amaranth (Amaranthus palmeri S. Wats.), Russian-thistle (Salsola tragus L.), and kochia (Kochia scoparia L.) at three growth stages (3 to 5 cm, 10 to 15 cm, and 20 to 30 cm).
Study Design: All trials were arranged in a randomized complete block design with four replications.
Place and Duration of Study: Field experiments were conducted in 2013, 2014, and 2015 in Lubbock, TX at the Texas A&M AgriLife Research and Extension Center near Lubbock, TX.
Methodology: Herbicide treatments consisted of a single postemergence application of 2,4-D choline + glyphosate at two rates, 2,4-D choline + glyphosate at two rates + glufosinate, 2,4-D choline + glyphosate + S-metolachlor, 2,4-D choline + glyphosate + acetochlor, 2,4-D choline + glufosinate, glyphosate, or glufosinate.
Results: The greatest level of weed control for all three weed species was achieved at the 3 to 5 cm timing; however, weed size was most critical for Palmer amaranth and Russian-thistle compared to kochia. Averaged over all three years, Palmer amaranth control decreased from 93 to 74% when evaluated 21 days after treatment following applications that included 2,4-D choline when applied to plants 3 to 5 and 10 to 30 cm, respectively. For Russian-thistle, control decreased from 98 to 78% when evaluated 21 days after treatment following treatments that included 2,4-D choline when applied to plants 3 to 5 and 10 to 30 cm, respectively. For kochia, control decreased from 98 to 84% when evaluated 21 days after treatment following treatments that included 2,4-D choline when applied to plant 3 to 5 and 10 to 30 cm, respectively.
Photoleitfähigkeit in Dünnfilmen Metall‐organischer Gerüste
Authors: Liu Xiaojing , Kozlowska Mariana , Okkali Timur , Wagner Danny , Higashino Tomohiro , Brenner‐Weiß Gerald , Marschner Stefan M. , Fu Zhihua , Zhang Qiang , Imahori Hiroshi , Bräse Stefan , Wenzel Wolfgang , Wöll Christof , Heinke Lars 
Published: April 2019

AbstractPhotoleitfähigkeit ist eine charakteristische Eigenschaft von Halbleitern. Hier präsentieren wir photoleitende kristalline MOF‐Dünnschichten mit einem An/Aus‐Photoleitfähigkeitsverhältnis von zwei Größenordnungen. Diese orientierten, oberflächenverankerten MOF‐Dünnschichten (SURMOFs) enthalten Porphyrin im Gerüst und C60‐Gastmoleküle in den Poren. Durch Vergleich mit Ergebnissen von Referenz‐MOF‐Strukturen sowie auf Basis von DFT‐Rechnungen kommen wir zu dem Schluss, dass eine Donor‐Akzeptor‐Wechselwirkung zwischen dem Porphyrin des MOF‐Wirtmaterials und den C60‐Gastmolekülen zu einer schnellen Ladungstrennung führt. Anschließend werden Löcher und Elektronen in separaten Kanälen durch Porphyrin und C60 transportiert. Die Fähigkeit, die Eigenschaften und Energieniveaus der aktiven Moleküle Porphyrin und Fulleren abzustimmen, kombiniert mit der kontrollierten Anordnung von Donor‐Akzeptor‐Paaren in einem solchen geordneten Gerüst, bietet ein enormes Potenzial, das An/Aus‐Photoleitfähigkeitsverhältnis weiter zu erhöhen.
Optimization of acoustic performances of a new tung oleic acid‐based composite polyurethane foam
Authors: Ji Yangjie , Chen Shuming 
Published: April 2019

ABSTRACTBio‐based polyurethane (PU) foam, different from traditional PU foam, is a new green environmental acoustic material. It can be used in the field of automobiles. In this work, a new tung oleic acid‐based composite PU (TOAPU) foam was prepared using tung oleic acid‐based polyol and polyether polyols 3630. It is important to optimize the formulation of TOAPU foam for better acoustic performance. The effect of each component on the acoustic performance of TOAPU is ordered by screening test. A1, silicone, and A33, the three components that have the greatest impact on the acoustic performance of TOAPU, are used as variables. The response surface method is used to create the model of the effects of different components on the acoustic properties of TOAPU. The model was optimized by using nondominated sorting genetic algorithm II method. The optimized acoustic performance property of TOAPU foams was synthesized by adding 0.27 g of A1, 1.03 g of A33, and 2.81 g of silicone oil. The experimental results show that the mean sound absorption coefficient and transmission loss can reach 0.515 and 21.389 dB. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47861.
Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix‐related gene expression partly via secretion of complement factor D
Authors: Ezure Tomonobu , Sugahara Misato , Amano Satoshi 
Published: April 2019

AbstractAging is associated with a decrease of extracellular matrix and an increase of senescent cells in the dermal layer. Here, to examine whether and how senescent cells are involved in aging‐related deterioration of the dermal layer, we cocultured dermal young fibroblasts (low‐passage number) with senescent cells (high‐passage number) in Transwells, in which the two cell types are separated by a semipermeable membrane. Young fibroblasts in coculture showed decreased collagen type I alpha 1 chain and elastin gene expression, and increased matrix metalloproteinase 1 (MMP1) gene expression. To identify causative factors, we compared gene expression of young and senescent cells and selected candidate secretory factors whose expression was increased by ≥2.5 in senescent fibroblasts. Then, we used siRNAs to knock down each of the 11 candidate genes in senescent fibroblasts in the coculture system. Knockdown of complement factor D (CFD) in senescent fibroblasts significantly reduced the increase of MMP1 in the cocultured young fibroblasts. In monocultures, treatment of young fibroblasts with CFD resulted in increased MMP1 gene expression, while knockdown of CFD in senescent fibroblasts decreased MMP1 gene expression. In addition, production of CFD was increased in culture medium of untreated senescent fibroblasts. Furthermore, CFD gene and protein expression were increased in the dermal layer of skin specimens from aged subjects (>70 years old), compared to young subjects (<20 years old). Overall, these results suggest that senescent cells negatively influence matrix production and promote degradation of nearby fibroblasts in the dermal layer, in part through secretion of CFD.
Preparation of Biomass‐Based Porous Carbons with High Specific Capacitance for Applications in Supercapacitors
Authors: Shen Honglong , Xia Xifeng , Ouyang Yu , Jiao Xinyan , Mutahir Sadaf , Mandler Daniel , Hao Qingli 
Published: April 2019

AbstractSupercapacitors are developing in terms of high power and energy densities. Carbon materials can meet this challenge to a certain extent. A sustainable high‐performance carbon material for supercapacitors was prepared through the simple and green thermal pyrolysis of orange peels as raw materials by using KOH as an activator. The biomass‐derived carbon materials activated at different temperatures were evaluated as electrode materials. The adsorption properties, structure, and surface elemental chemical states of the prepared materials were studied. Carbonation temperature plays a key role in the preparation of materials, and it has different effects on the physical and electrochemical properties of materials. The opc700 and opc800 samples have large pore volumes, which provide the necessary space for the storage of electrolyte ions. The temperature has a pronounced effect on the specific surface area and the electrochemical performance. The specific surface area of opc800 is as high as 2004 m2 g−1 and the pore volume is 1.24 cm3 g−1. The maximum specific capacity of opc800 is 306.6 F g−1 at 0.5 A g−1 and the specific capacitance is 251.2 F g−1 at 20 A g−1.
Self‐Assembled Three‐Dimensional Graphene Aerogel with an Interconnected Porous Structure for Lithium‐Ion Batteries
Authors: Huang Liang‐ai , He Zhishun , Guo Jianfeng , Pei Shi‐en , Shao Haibo , Wang Jianming 
Published: April 2019

AbstractWe report a low‐cost method for the fabrication of three‐dimensional graphene aerogel (3DGA) with an interconnected porous structure by using a simple hydrothermal reaction of graphite oxide (GO) in the presence of treated filter paper and subsequent annealing. In the hydrothermal process, the filter paper prevents GO sheets from intimate layer‐by‐layer stacking and serves as linkers to construct a three‐dimensional structural graphene hydrogel (GH). The pure 3DGA with an interconnected porous structure is achieved through the calcination of the GH with a three‐dimensional network structure. The as‐fabricated 3DGA electrode exhibits an improved lithium storage performance with a capacity of 712.8 mAh g−1 after 200 cycles at a rate of 200 mA g−1. More importantly, the electrode still shows a reversible capacity of 237.1 mAh g−1 even at a high rate of 1600 mA g−1, demonstrating its remarkable rate capability. The excellent electrochemical performance of the 3DGA electrode is ascribed to its distinct interconnected porous nanoarchitecture with exposed defects and edges as well as large specific surface area. The present design concept of 3DGA may provide a novel strategy for the preparation of advanced carbon materials for electrochemical energy storage systems.
Synthesis of Oligo(1,8‐pyrenylene)s: A Series of Functional Molecular Liquids
Authors: Walsh Joshua C. , Hogan David T. , Williams Kerry‐Lynn M. , Brake Simon D. , Venkataramana Gandikota , Misener Tara A. , Wallace Brandon J. , Johnson Richard P. , Thompson David W. , Zhao Yuming , Wagner Brian D. , Bodwell Graham J. 
Published: April 2019

AbstractA monomer‐through‐pentamer series of oligo(1,8‐pyrenylene)s was synthesized using a two‐step iterative synthetic strategy. The trimer, tetramer, and pentamer are mixtures of atropisomers that interconvert slowly at room temperature (as shown by variable‐temperature NMR analysis). They are liquids well below room temperature, as indicated by POM, DSC and SWAXS analysis. These oligomers are highly fluorescent both in the liquid state and in dilute solution (λF,max = 444–457 nm, φF = 0.80) and an investigation of their photophysical properties demonstrated that delocalization plays a larger role in their excited states than it does in related pyrene‐based oligomers.
The use of isotopes in evolving groundwater circulation models of regional continental aquifers: The case of the Guarani Aquifer System
Authors: Kirchheim Roberto Eduardo , Gastmans Didier , Chang Hung Kiang , Gilmore Troy E. 
Published: April 2019

AbstractThe Guarani Aquifer System (GAS) has been studied since the 1970s, a time frame that coincides with the advent of isotopic techniques in Brazil. The GAS isotope data from many studies are organized in different phases: (a) the advent of isotope techniques, (b) consolidation and new applications, (c) isotope assessments and hydrochemistry evolution, and (d) a roadmap to a new conceptual model. The reasons behind the phases, their methodological approaches, and impacts on the regional flow conceptual models are examined. Starting with local δ2H and δ18O assessments of values for water fingerprinting and estimates of recharge palaeoclimate scenarios, studies evolved to more integrated approaches based on multiple tracers. Stable isotope application techniques were consolidated during the 1980s, when new dating approaches dealing with radiogenic and heavy isotopes were introduced. Through the execution of an international transboundary project, the GAS was studied and extensively sampled for isotopes. These results have triggered wider application of isotope techniques, reflecting also world research trends. Presently, hydrochemical evolution models along flow lines from recharge to discharge areas, across large‐scale tectonic features within the entire sedimentary basin, are being combined with residence time estimates at GAS outcrop areas and deep confined units. In a complex system, it is normal that many, and even contradictory hypotheses are proposed, but isotope techniques provide a unique chance to test them. Stable isotope assessments are still needed near recharge areas, and they can be combined with groundwater classical dating procedures, complemented by newer techniques (3H‐3He, CFCs, and SF6). Recent noble gas sampling and world pioneer analytical efforts focused on the confined units in the GAS will certainly led to new findings on the overall GAS circulation. The objective of this article is to discuss how isotope information can contribute to the evolution of conceptual groundwater flow models for regional continental aquifers, such as the GAS.