bluuebunny/crossref_metadata_2025_split huggingface dataset:
The reproducibility of protocols used to mediate a current-induced vasodilation in the human cutaneous microcirculation
Authors: Guigui Alicia , Liaigre Léa , Roustit Matthieu , Loader Jordan 
Published: November 2024

Introduction
Current-induced vasodilation (CIV) can be used to assess the prostacyclin (PGI2) pathway. This study, for the first time, evaluated the reproducibility of several protocols used to mediate a CIV.

Methods
Three CIV protocols were evaluated in 10 healthy participants who completed four testing sessions. Two testing sessions were conducted on the calf, separated by a period of seven days allowing interday reproducibility to be assessed. Two testing sessions were also conducted seven days apart on the forearm. At each testing session, cutaneous microvascular assessments were conducted for one hour on the right limb of interest before assessments were immediately performed on the left limb, allowing for intersite, intraday reproducibility to be evaluated. Assessments were then repeated at the same site on the right limb, allowing for intrasite, intraday reproducibility to be evaluated. Reproducibility was assessed using the within-subject coefficients of variation and the intra-class correlation coefficients.

Results
Protocol A (Pulses of 0.03, 0.06, 0.09, 0.12, 0.15, and 0.18 mA for 10 s each; 60 s intervals), Protocol B (0.1 mA for 60 s), and Protocol C (2 pulses of 0.1 mA for 10s each; 240 s interval) had good to excellent interday reproducibility for calf and forearm assessments. The intrasite, intraday reproducibility of each protocol was less clear. Intersite testing didn’t improve intraday reproducibility. Reproducibility was consistently unacceptable when the microvascular response to the electrical stimulation was expressed as the absolute change and the percentage change between baseline values and the maximal plateau. A microvascular response wasn’t induced ∼10% of assessments on either the calf or forearm.

Conclusions
This study indicates that a CIV is most reproducible with interday testing and when data are expressed as the maximal plateau in perfusion units or as cutaneous vascular conductance, and as the area under the curve.
Análise sobre os fatores que impactam a qualidade da educação básica dos municípios brasileiros
Authors: Santos Sara Ferreira 
Published: November 2024

À luz da literatura e da relevância da educação como motor propulsor para o desenvolvimento de uma nação, o presente estudo objetivou analisar fatores que, de forma integrada, exercem influência sobre a qualidade da educação básica, a partir do Ideb, no intuito de oferecer subsídio para acompanhamento e controle com vistas à qualidade do gasto púbico em educação. Nesse interim, buscou-se analisar a associação entre fatores de governança, socioeconômicos e políticas públicas educacionais e o Ideb auferido nos municípios brasileiros, no período de 2017 e 2019. Ademais, com metodologia de natureza quantitativa, explicativa, utilizou-se o modelo estatístico Tobit. Com base na análise dos dados, infere-se que fatores de governança na gestão municipal, políticas públicas educacionais e capacidade econômica da população estão positivamente associadas ao desempenho educacional. No tocante ao nível de pobreza da região a variável mostrou-se inversamente relacionada ao desempenho da educação. A variável orçamento, apontou uma associação negativa em relação ao Ideb, mostrando que municípios que gastaram menos alcançaram melhores resultados educacionais, revelando que o volume de gastos, por si só, não é determinante para aumentar a qualidade da educaçao. Assim, os resultados surgem como intrumento de apoio e contribuição prática, tanto para a literatura, quanto para os gestores públicos, auxiliando-os na tomada de decisão, no tocante à melhoria do gasto público em educação, no Brasil, sugerindo que a melhora dos índices educacionais requer uma análise multifatorial, incluindo renda, capacidade de gestão, polítcas públicas educacionais.
Rare Thymoma With Solitary Liver Metastasis
Authors: Abusuliman Mohammed , Aboeldahb Moataz , Olimy Abdullah , Abbas Omar , Abusuliman Amr , Jamali Taher , Gavidia Rosario Agustin , Yuan Lisi , Pompa Robert 
Published: November 2024

ABSTRACT
Thymomas are rare, malignant, epithelial tumors of the thymus gland. Extrathoracic metastasis of thymoma is exceedingly rare, particularly when isolated to the liver. We report an 89-year-old man who presented with urinary retention. Exploratory computed tomography imaging revealed a heterogeneous mass in the aortopulmonary window and a 1.9 cm lesion in the left hepatic lobe. Results from magnetic resonance imaging, positron emission tomography-computed tomography, and histopathological analysis of biopsy samples collectively supported a diagnosis of metastatic type B2 thymoma. To the best of our knowledge, this is the oldest patient to be diagnosed with metastatic type B2 thymoma. Metastatic thymoma is difficult to identify, and patients with mediastinal mass identified after any presentation should be evaluated for malignant spread.
Impacto de la mutación T315I en el pronóstico de la leucemia mieloide crónica
Authors: Kaleem Bushra , Shahab Sadaf , Shamsi Tahir Sultan 
Published: November 2024

Resumen

Objetivos
Las mutaciones dominio quinasa BCR-ABL1 son una de las principales causas de resistencia a los inhibidores de la tirosina quinasa (ITK) en la leucemia mieloide crónica (LMC), siendo la mutación T315I la más resistente a tratamiento. El objetivo del presente estudio es determinar la frecuencia de T315I y su impacto en el pronóstico de la enfermedad, en términos de progresión de enfermedad y supervivencia.

Métodos
Se clasificó como pacientes sin respuesta a tratamiento a aquellos pacientes con respuesta clasificada como “en advertencia” o que no mostraron respuesta completa a tratamiento con ITK, según los criterios de LeukemiaNet (ELN). La mutación T315I se detectó mediante el sistema de mutación refractario a la amplificación por PCR (ARMS-PCR), cuyo resultado fue posteriormente validado mediante secuenciación. Se realizó un seguimiento de 96 meses para observar el impacto de la mutación en el pronóstico de estos pacientes.

Resultados
De los 102 pacientes que no respondieron a tratamiento, la mutación T315I fue detectada en el 21,6 %, con mayor preponderancia entre las mujeres. El 59 % de los pacientes portadores de la mutación presentaron un riesgo basal bajo por la escala Sokal. El 58,8 % de los portadores desarrollaron progresión de la enfermedad a la fase blástica. La supervivencia general (periodo de estudio: 96 meses) de los portadores de la T315I fue del 81,8 % de los pacientes portadores. Los pacientes que progresaron a la fase blástica presentaron mayor probabilidad de ser portadores de la mutación T315I.

Conclusiones
Una respuesta subóptima o falta de respuesta a tratamiento con ITK indica el desarrollo de resistencia debido a la presencia de la mutación T315I o de otras mutaciones. La identificación temprana de esta u otras mutaciones ayudaría a reorientar el tratamiento del paciente.
Marketing von elektronischen Informationsdienstleistungen
Authors: Georgy Ursula 
Published: November 2024

Zusammenfassung
Das Thema Informationsmarketing nahm Ende der 1990er- und Anfang der 2000er-Jahre an Fahrt auf, nachdem sich das Dienstleistungsmarketing als Spezialform des Marketings in vielen Bereichen und Branchen bereits etabliert hatte. Durch ChatGPT und andere KI-Tools hat das Thema noch einmal eine deutliche Wendung erfahren. Der Beitrag gibt einen Überblick über die Entwicklung der letzten 25 Jahre; zudem wird ein Ausblick auf mögliche Entwicklungen gewagt.
Historische Obstsorten neu entdeckt: Citizen Science an der Universitätsbibliothek Kiel
Authors: Christ Andreas , Vetter Angila 
Published: November 2024

Zusammenfassung
Das Projekt zum „Obstbuch“ von 1859 der Universitätsbibliothek Kiel verbindet historische Forschung mit einem modernen, digitalen Ansatz der Citizen Science. Durch die Einbeziehung von Bürgerwissenschaftlerinnen und Bürgerwissenschaftlern werden historische Obstsorten botanisch analysiert, um Erkenntnisse für den Sortenerhalt zu gewinnen. Der Beitrag stellt die methodischen Ansätze vor, beleuchtet die Bedeutung für die botanische Forschung und diskutiert Aspekte guter wissenschaftlicher Praxis. Dabei wird das Obstbuch als Ausgangspunkt für die Untersuchung aktueller, gesellschaftsrelevanter Fragestellungen genutzt, die mithilfe moderner digitaler Methoden der Citizen Science erforscht werden.
Increased specificity of the “GFAP/UCH-L1” mTBI rule-out test by age dependent cut-offs
Authors: Ladang Aurélie , Vavoulis George , Trifonidi Ioulia , Calluy Emma , Karagianni Katerina , Mitropoulos Athanasios , Vlachos Konstantinos , Cavalier Etienne , Makris Konstantinos 
Published: November 2024

Abstract

Objectives
Mild traumatic brain injury (mTBI) remains challenging to diagnose effectively in the emergency department. Abbott has developed the “GFAP/UCH-L1” mTBI test, to guide the clinical decision to perform a computed tomography (CT) head scan by ruling out the presence of mTBI. We evaluated the diagnostic accuracy of the “GFAP/UCH-L1” mTBI test in a Greek cohort and established age-dependent cut-offs.

Methods
A total of 362 subjects with suspected mTBI and admitted to the Emergency department of the KAT General Hospital of Athens, Greece were recruited for the study. All subjects underwent a CT head scan to establish the diagnosis of mTBI. GFAP and UCH-L1 were measured using Alinity I (Abbott). 163 healthy subjects served as controls.

Results
Using the manufacturer’s cut-offs (35 ng/L for GFAP and 400 ng/L for UCH-L1), the “GFAP/UCH-L1” mTBI test had a sensitivity of 99.1 % and a specificity of 40.6 %. However, the specificity dropped to 14.9 % in patients older than 65 years old. By defining a new cut-off of 115 ng/L for GFAP and 335 ng/L specifically for patients older than 65 years, specificity was increased up to 30.6 % without changing test sensitivity and the number of CT head scans avoided was doubled in this subgroup.

Conclusions
The “GFAP/UCH-L1” mTBI test is an efficient “rule-out test” to exclude patients suffering from mTBI. By adjusting the cut-offs in patients older than 65 years old, we could significantly increase the number of CT head scans avoided without affecting the sensitivity. These new cut-offs should be externally validated.
Time pressure in diagnosing written clinical cases: an experimental study on time constraints and perceived time pressure
Authors: Hooftman Jacky , Olson Andrew P.J. , McQuade Casey N. , Mamede Sílvia , Wagner Cordula , Zwaan Laura 
Published: November 2024

Abstract

Objectives
Time pressure and time constraints have been shown to affect diagnostic accuracy, but how they interact is not clear. The current study aims to investigate the effects of both perceived time pressure (sufficient vs. insufficient time) and actual time constraints (lenient vs. restricted time limit) with regard to diagnostic accuracy.

Methods
Residents from two university-affiliated training programs in the USA participated in this online within-subjects experiment. They diagnosed cases under two perceived time pressure conditions: one where they were told they had sufficient time to diagnose the cases and one where they were told they had insufficient time. The actual time limit was either restricted or lenient (± one standard deviation from the mean time to diagnose). Participants provided their most likely diagnosis and a differential diagnosis for each case, and rated their confidence in their most likely diagnosis.

Results
A restricted time limit was associated with lower accuracy scores (p=0.044) but no effects of perceived time pressure on diagnostic accuracy were found. However, participants self-reported feeling more time pressure when they thought they had insufficient time (p<0.001). In addition, there was an effect of the actual time limit (p=0.012) and perceived time pressure (p=0.048) on confidence.

Conclusions
This study showed that a restricted time limit can negatively affect diagnostic accuracy. Although participants felt more time pressure and were less confident when they thought they had insufficient time, perceived time pressure did not affect diagnostic accuracy. More research is needed to further investigate the effects of time pressure and time limits on diagnostic accuracy.
Exploring the effect of translating non-verbal elements in film subtitles
Authors: Mouzannar Melissa E. , Abou Fadel Saad Gina E. 
Published: November 2024

Abstract
This study investigates the relevance of including the translation of non-verbal elements in film subtitles. It suggests that non-verbal elements play a crucial role in understanding films and, consequently, need to be considered when translating: what is non-verbal becomes written in the translation, carrying a significant semantic load. The article presents an empirical study adopting a qualitative approach that aims to explore and analyse the effect of including non-verbal translation in film subtitles, particularly in a Lebanese movie titled The Insult, subtitled in French. The results show that non-verbal communication and its semantic value should be explicit in subtitling to the foreign-language audience, whether explicitly apparent, graphically represented, or implicitly present between words and lines.
Posedición y paridad humano-máquina en traducción automática neuronal: Un estudio empírico desde la traducción profesional
Authors: Toledo-Báez Cristina 
Published: November 2024

Abstract
Albeit controversial, human-machine parity in neural machine translation has been claimed, but there is a lack of empirical studies providing concrete evidence. This article aims to present part of the results of an experiment conducted under the NEUROTRAD project where human-machine parity in neural machine translation is approached from the perspective of post-editing effort. Combining descriptive statistics, Friedman test for hypothesis testing, and Spearman correlation coefficients, our study analyses the answers to two questionnaires by 36 Spanish freelance translators in order to test 1) whether the type of translation —human, machine translation, and, as a novelty, post-edited machine translation— impacts on the perceived post-editing effort, time, and quality and 2) whether the participant’s professional experience correlates with the perceived post-editing effort, time, and quality. Results revealed that, on the one hand, the type of translation has no influence on the perceived post-editing effort (p<0.953), time (p<0.439) and quality (p<0.390) and, on the other hand, having more post-editing experience does not correlate with 1) perceived post-editing effort for post-edited machine translation (p<0.094); 2) perceived post-editing time for human translation (p<0.259) and post-edited machine translation (p<0.187) and 3) perceived translation quality for post-edited machine translation (p<0.10).
Fatigue life of friction stir spot welds between Z91 magnesium alloy and ENAW7075-T651 aluminum alloy
Authors: Ekinci Omer , Balalan Zulkuf 
Published: November 2024

Abstract
Magnesium (Mg) and aluminum (Al) alloys are considered to be among the lightest structural metals. Using these materials in a design can considerably decrease weight, which brings many benefits like reducing fuel consumption and increasing the performance of an aircraft or a ground vehicle. However, these alloys are too difficult to be joined via fusion welding techniques. In this context, welding AZ91 Mg alloy to ENAW7075-T651 Al alloy by the solid-state welding method of friction stir spot welding was investigated comprehensively. These alloys were welded by utilizing a tool with a triangle pin and various tool rotational speeds (1,000, 1,400, and 1,800 rpm) and welding times (3 and 6 s). Macro and microstructure of the welds and their hardness, tensile strength, and tension-compression fatigue life were determined. Generally, an improvement in the mechanical properties of the weld was observed by increasing the welding time due to the expansion of the joining area. The welding with the best mechanical properties was obtained at 1,400 rpm, and the worst at 1,800 rpm. All the welds failed from the weld area during the tensile and fatigue tests and exhibited a brittle fracture mode due to the formation of intermetallic compounds in the welds.
Degeneracy mediated thermal emission from nanoscale optical resonators with high-order symmetry
Authors: Wang Zexiao , Li Jiayu , Li Zhuo , Liu Xiu , Zhong Yibai , Huang Tianyi , Shen Sheng 
Published: November 2024

Abstract
Conventional thermal emitters, such as a blackbody or the incandescent filament of a light bulb, lack the directionality or narrow linewidth required in many applications such as thermophotovoltaics and infrared sensing. Although thermal emission from bulk materials is well understood based on phenomenological heat transfer concepts like emissivity and the framework of classical electrodynamics, there still remains a significant gap in our understanding of thermal emission at the nanoscale. In this work, by leveraging the quasi-normal mode theory, we derive a general and self-consistent formalism to describe the thermal radiation from nanoscale resonant thermal emitters with high-order symmetric geometries, which are the basic building blocks of metasurfaces and metamaterials. The complex symmetrical geometries of the emitters yield degeneracy of quasi-normal modes. The introduction of the degeneracy can strongly mediate far-field thermal emission from nanoscale resonators, which is closely correlated to the number of degenerate modes and the coupling among the degenerate modes. Our formalism from the quasi-normal mode theory serves as a general guideline to design the complex metastructures with high-ordered degeneracy to achieve optimized absorption or emission capabilities.
Crystal structure of di-glycylglycinium squarate dihydrate, C12H22N4O12, at 105 K
Authors: Gomes Etelvina de Matos , Baptista Rosa M.F. , Görbitz Carl Henrik 
Published: November 2024

Abstract
C12H22N4O12, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 6.7126(4) Å, b = 7.7536(5) Å, c = 8.5279(5) Å, α = 89.4803(14)°, β = 86.2595(14)°, γ = 79.4035(14)°, V = 435.35(5) Å3, Z = 2, R

gt
(F) = 0.0323, wR

ref
(F
2) = 0.0908, T = 105(2) K.
Acryloyl starch/carboxymethyl cellulose grafting copolymerization composite hydrogel for efficient adsorption of methylene blue
Authors: Liu Xue-Li , Sun Ya-Li , Hu Zhong-Zhu , Zhu Chun-Feng 
Published: November 2024

Abstract
An efficient composite adsorbent was prepared based on acryloyl starch/carboxymethyl cellulose grafting copolymerization for the adsorptive removal of methylene blue. The developed composite hydrogels were characterized by means of FTIR, SEM (EDS-SEM), and XRD. Various parameters affecting the removal of methylene blue such as the type of adsorbents, pHs, the amount of adsorbents dosage, initial methylene blue concentration, and contact time were optimized using a series of batch adsorption experiments. The experimental data of the adsorption process were more fitted to Langmuir isotherm (R
2 = 0.9898) with a maximum adsorption capacity of 483.5 mg/g and batch kinetic experiments revealed that the adsorption process followed quasi-second-order kinetic model. The adsorption process was rapid and equilibrium was reached within 30 min. When the adsorption dosage is 0.2 g L−1, the adsorption yield for 100 mg L−1 methylene blue solution can reach 96.7 %. Therefore, acryloyl starch/carboxymethyl cellulose grafting copolymerization composite hydrogel present excellent adsorption efficiency, shows the potential application in future treatment of dyes wastewater.
Diagnostic reference levels (DRL) in Computed Tomography during the period 2018-2022 in a private hospital in Chile
Authors: Seijas Acosta Jugleys , Sanguesa M Javiera , Soffia S Pablo , Fabri G Daniella 
Published: November 2024

The aim of this study was to compare and optimize the diagnostic reference levels (DRL) of our institution obtained over 5 years, in order to find the appropriate balance between the patient dose and the quality of the clinical image for the most frequently used CT examinations.The typical values of 6 CT scanners of an institution were evaluated, taking as a reference the DRLs established in 2018. An optimization process was initiated in order to find the best balance between dose- diagnostic quality, finding that the DRLs obtained during that year were well below those published by the ACR, so we proceeded to prioritize the quality of the image by reasonably increasing the doses to the patient. In 2022, we purchased other patient dose monitoring software and got new optimized DRLs.The results obtained from the typical values of 2018 versus 2022 had a difference of 25% to 30%, with the DRLs of 2022 being higher as we were looking for, finding a significant improvement in the quality of the diagnostic images. The medians obtained are within what is published internationally, which is an indicator that our DRLs are within international standards.This research helped our CT Service considerably to obtain typical values with excellent quality of diagnostic images, and to standardize the protocols for all our CT scanners despite being of different brands and technology.
NDM-1 and KPC-3 co-producing Klebsiella pneumoniae ST512 in bronchial secretion from a patient in an intensive care unit of a Greek Tertiary Care Hospital
Authors: Chatzidimitriou Maria , Tsolakidou Pandora , Voulgaridis Apostolos , Kyriazidi Maria Anna , Chatzopoulou Fani , Mavridou Maria , Varlamis Sotiris , Mitka Stella , Vagdatli Eleni 
Published: November 2024

AbstractThis study investigated a strain of Klebsiella pneumoniae, identified as GRTHES, which exhibited extensive antibiotic resistance. The strain was resistant to all beta-lactams, including combinations with newer agents such as meropenem/vaborbactam and imipenem/relebactam, as well as to aminoglycosides, fluoroquinolones, fosfomycin, trimethoprim-sulfamethoxazole and colistin. It remained susceptible to tigecycline. Whole-genome sequencing was performed by Ion Torrent platform on the K. pneumoniae strain. Genomic analysis revealed a genome length of 5,808,650 bp and a GC content of 56.9%. Advanced sequencing techniques and bioinformatic tools were used to assess resistance genes and plasmid replicons, highlighting the emergence of multidrug resistance and virulence traits. The strain carried blaNDM-1 and blaKPC-3 genes and was designated to KL107 O2afg type. Colistin resistance-associated mgrB/pmrB gene mutations were present, and the strain also harbored yersiniabactin-encoding ybt gene. Our findings provide insights into the genomic context of blaNDM-1 and blaKPC-3 carbapenemase-producing K. pneumoniae and emphasize the importance of continuous surveillance and novel therapeutic strategies to combat multidrug-resistant bacterial infections. It is the first time that an NDM-1 and KPC-3 co-producing strain of K. pneumoniae ST512 is identified in Greece. This study highlights the essential role of genomic surveillance as a proactive strategy to control the spread of carbapenemase-producing K. pneumoniae isolates, particularly when key antimicrobial resistance genes, such as blaNDM-1 and blaKPC-3, are plasmid-mediated. Detailed characterization of these isolates could reveal plasmid similarities that facilitate adaptation and transmission within and between hospitals. Although data on patient movements are limited, it is plausible that carbapenem-resistant isolate was selected to co-produce KPC and NDM through plasmid acquisition.