bluuebunny/crossref_metadata_2025_split huggingface dataset:
TÜRKİYE’DE ENFLASYON, DÖVİZ KURU VE TÜKETİCİ KREDİLERİ ARASINDAKİ NEDENSELLİK İLİŞKİSİNİN ANALİZİ
Authors: DURMUŞ Savaş , ŞAHİN Dilek 
Published: March 2019

Bu çalışmanın amacı, 2006:Q1 ve 2018:Q2 çeyrek
dönemleri arasında Türkiye’de tüketici kredileri ve bazı makroekonomik değişkenler
arasındaki ilişkiyi analiz etmektir. Bu bağlamda çalışmada; tüketici kredileri,
enflasyon, döviz kuru, faiz ve para arzı değişkenleri kullanılmıştır. İlk
olarak değişkenlerin durağanlığı yapısal kırılmasız birim kök testi (ADF, PP)
ve bir yapısal kırılmaya izin veren (Zivot-Andrews) birim kök testi ile analiz
edilmiştir. Değişkenler arasında uzun dönemli bir ilişkinin olup olmadığı
Gregory-Hansen yapısal kırılmalı eşbütünleşme testi ile araştırılmıştır. Değişkenler
arasındaki nedenselliğin yönü Toda-Yamamato nedensellik testi ile ele
alınmıştır. Toda-Yamamoto nedensellik
testinde, faiz oranı ve tüketici kredileri arasında çift yönlü nedensellik
ilişkisinin olduğu görülmüştür. Ayrıca, para arzından tüketici kredilerine
doğru tek yönlü nedensellik ilişkisi tespit edilmiştir.
Researchers May Need Additional Data Curation Support
Authors: Miller Robin E. 
Published: March 2019

A Review of:
Johnston, L. R., Carlson, J., Hudson-Vitale, C., Imker, H., Kozlowski, W., Olendorf, R., & Stewart, C. (2018). How important are data curation activities to researchers? Gaps and opportunities for academic libraries. Journal of Librarianship and Scholarly Communication, 6(1), 1-24. https://doi.org/10.7710/2162-3309.2198
Abstract
Objective – To identify the data curation activities most valued by researchers at universities.
Design – Focus group and survey instrument.
Setting – Six R1: Doctoral Universities in the United States of America that are part of a Data Curation Network (DCN) project to design a shared data curation service.
Subjects – 91 researchers, librarians, and support staff.
Methods – The authors used focus group methodology to collect data about valued data curation activities, current practices, and satisfaction with existing services or activities. Six focus groups were conducted at participants’ places of employment. Participants reviewed a list of 35 possible data curation activities, including documentation, data visualization, and rights management. A card-swapping exercise enabled subjects to rank the most important issues on a scale of 1-5, with “most important” activities becoming the subject of a facilitated discussion. In a short paper-based survey, participants also noted whether a data curation practice is in place at their institution, and their satisfaction with the practice.
Main Results – Twelve data curation activities were identified as “highly rated” services that academic institutions could focus on providing to researchers. Documentation, Secure Storage, Quality Assurance, and Persistent Identifier were the data curation activities that the majority of participants rated as “most important.” Participants identified the data curation practices in place at their institutions, including documentation (80%), secure storage (75%), chain of custody (64%), metadata (63%), file inventory or manifest (58%), data visualization (58%), versioning (56%), file format transformations (55%), and quality assurance (52%). Participants reported low levels of satisfaction with their institutions’ data curation activities.
Conclusion – Academic libraries have an opportunity to develop or improve existing data curation services by focusing on the twelve data curation activities that researchers, staff, and librarians value but that could be implemented in a more satisfactory way. The authors conclude that their organization, the Data Curation Network, has an opportunity to improve data curation services or to offer new or expanded services.
Evaluation of Chemical and Mineralogical Structure of Davutoğlan Bird Sanctuary Clay for It’s Antimicrobial Efficiency
Authors: Sopacı Şaziye Betül 
Published: March 2019

In this
study we examined possible antimicrobial properties of clay specimen taken from
Davutoğlan Bird Sanctuary which is located in Kıztepe skirts as a remote
ecological environment to industrial areas. Antimicrobial effects of Gram (-) (Escherichia coli, Pseudomonas aeruginosa)
and Gram (+) (Bacillus subtilis,
Enterococcus faecalis, Staphylococcus aureus) pathogenic bacteria species
on clay samples collected from the region were investigated. Between 0.5-1.5
g/mL concentration range clay has been shown to affect bacterial growth with
the bacterial inoculations of 105 cfu/mL. X-ray diffraction (XRD),
X-ray fluorescence (XRF) and thermogravimetric (TG) studies of clay minerals
and chemical structure have been determined in parallel with the study of
antimicrobial activity in order to support these results and to explain the
findings. In addition, scanning electron microscopy (SEM) and
Brunauer–Emmett–Teller (BET) methods were used to determine the pore structure
and surface area of the clay. The obtained results were correlated with antimicrobial activity.
According to XRD, XRF and TG analysis results, illite, dolomite and calcite
were found to be major clay minerals from the samples taken from the area. It
was found that they have a large surface area of 57,002 m2/g
according to BET results. It is also concluded that since the large surface
area gives strong absorbent properties and supplies a suitable interface for
oxidation, suppression of the bacterial growth is observed.
Post-Diuretic Pulmonary Edema A Case Report
Authors: Liu Lixia , Zhang Qian , Zhang Tao , Wu Xinhui , Sun Lixiao , Li Bin , Wang Xiaoting , Chao Yangong , Hu Zhenjie 
Published: March 2019

Abstract
Background
Post-diuretic pulmonary edema(PDPE)is a special type of acute pulmonary edema, results from rapid blood volume loss caused by diuretics. Inappropriate administration of diuretics and inotropic agent, which is mainstay of treatment of pulmonary edema Classically, might have been a critical mistake in PDPE.Maintaining appropriate volume status and beta receptor blockers is the key to reversing the progress of PDPE. However,this condition remains unfamiliar to the medical community, making it an underdiagnosed and underreported condition.
Case representation
A 71-year-old patient who initially was diagnosed to have acute respiratory distress syndrome (ADRS) in intensive care unit (ICU) but got further dyspnea after rapid volume depletion. Point of care ultrasound (POCUS) examination showed worsened pulmonary edema with inferior vena cava collapsed during inspiratory period and a small but hyperdynamic left ventricular(LV). The patient subsequently improved with fluid, beta blocker, increased sedation, and paralysis.
Conclusion
We first put forward the concept of post-diuretic pulmonary edema,in order to remind medical staff to pay attention to this type of pulmonary edema and understand its pathophysiological mechanism.
Mitigating Alzheimer’s Disease with Natural Polyphenols: A Review
Authors: Gaudreault Roger , Mousseau Normand 
Published: March 2019

:According to Alzheimer’s Disease International (ADI), nearly 50 million people worldwide were living with dementia in 2017, and this number is expected to triple by 2050. Despite years of research in this field, the root cause and mechanisms responsible for Alzheimer’s disease (AD) have not been fully elucidated yet. Moreover, promising preclinical results have repeatedly failed to translate into patient treatments. Until now, none of the molecules targeting AD has successfully passed the Phase III trial. Although natural molecules have been extensively studied, they normally require high concentrations to be effective; alternately, they are too large to cross the blood-brain barrier (BBB).:In this review, we report AD treatment strategies, with a virtually exclusive focus on green chemistry (natural phenolic molecules). These include therapeutic strategies for decreasing amyloid-β (Aβ) production, preventing and/or altering Aβ aggregation, and reducing oligomers cytotoxicity such as curcumin, (-)-epigallocatechin-3-gallate (EGCG), morin, resveratrol, tannic acid, and other natural green molecules. We also examine whether consideration should be given to potential candidates used outside of medicine and nutrition, through a discussion of two intermediate-sized green molecules, with very similar molecular structures and key properties, which exhibit potential in mitigating Alzheimer’s disease.
Nuances in Alzheimer’s Genetic Risk Reveal Differential Predictions of Non-demented Memory Aging Trajectories: Selective Patterns by APOE Genotype and Sex
Authors: McFall G. Peggy , Bäckman Lars , Dixon Roger A. 
Published: March 2019

Background:Apolipoprotein E (APOE) is a prominent genetic risk factor for Alzheimer’s disease (AD) and a frequent target for associations with non-demented and cognitively impaired aging. APOE offers a unique opportunity to evaluate two dichotomous comparisons and selected gradations of APOE risk. Some evidence suggests that APOE effects may differ by sex and emerge especially in interaction with other AD-related biomarkers (e.g., vascular health).Methods:Longitudinal trajectories of non-demented adults (n = 632, 67% female, Mage = 68.9) populated a 40-year band of aging. Focusing on memory performance and individualized memory trajectories, a sequence of latent growth models was tested for predictions of (moderation between) APOE and pulse pressure (PP) as stratified by sex. The analyses (1) established robust benchmark PP effects on memory trajectories, (2) compared predictions of alternative dichotomous groupings (ε4- vs ε4+, ε2- vs ε2+), and (3) examined precision-based predictions by disaggregated APOE genotypes.Results:Healthier (lower) PP was associated with better memory performance and less decline. Therefore, all subsequent analyses were conducted in the interactive context of PP effects and sex stratification. The ε4-based dichotomization produced no differential genetic predictions. The ε2-based analyses showed sex differences, including selective protection for ε2-positive females. Exploratory follow-up disaggregated APOE genotype analyses suggested selective ε2 protection effects for both homozygotic and heterozygotic females.Conclusion:Precision analyses of AD genetic risk will advance the understanding of underlying mechanisms and improve personalized implementation of interventions.
Convenient Synthesis of New Heterocycles Containing the Quinoxaline Ring System
Authors: Mohamed Hanan A. , Alotaibi Mohammad Hayal , Kariuki Benson M. , El-Hiti Gamal A. 
Published: March 2019

:
The aim of the current article was to describe simple procedures for the synthesis of new
heterocycles incorporating the quinoxaline moiety using benzene-1,2-diamine and quinoxaline-2,3-
dithiol as precursors. Simple synthetic methods are described for the synthesis of new heterocycles using
commercially available chemicals. Also, the new compounds were determined using analytical and
spectroscopic methods including single X-ray crystal structures. A series of new heterocycles containing
the quinoxaline nucleus have been synthesized in good yields using simple and convenient procedures.
A process has been described for the synthesis of new heterocycles containing the quinoxaline
moiety that might be difficult to synthesize by other routes.
Synthesis, Cytotoxic, Antibacterial and Free Radical Scavenging Activities of Schiff Bases Derived from 1,2,4-Triazole
Authors: Gan Kwang-Chun , Sim Kooi-Mow , Lim Tuck-Meng , Teo Kah-Cheng 
Published: March 2019

:
A series of new 1,2,4-triazole Schiff bases incorporating a chlorinated indole moiety were
prepared from the condensation reaction of 4-amino-5-mercapto-3-[(5-chloro-2-methyl-1H-indol-3-
yl)methyl]1,2,4-triazole with substituted benzaldehydes in the presence of (+)-tartaric acid as an acidic
catalyst. The structures of Schiff bases were elucidated by FTIR, NMR and mass spectral data. The cytotoxic,
antibacterial and free radical scavenging activities of Schiff bases were performed using MTT,
96-well microbroth dilution and DPPH assays, respectively. Schiff bases 3k and 3l with both electron
donating groups at meta and para positions of the phenyl ring demonstrated higher cytotoxic activity
against COLO-205 and A549 cell lines. On the other hand, Schiff base 3f comprising p-chlorophenyl
substituent exhibited significant inhibition against Bacillus cereus and Staphylococcus aureus at MIC
3.91 μg/ml and 15.63 μg/ml, respectively. The results of the free radical scavenging activity revealed
that Schiff bases with the presence of a Cl or OCH3 group in the para position of the phenyl ring act as
a better antioxidant than BHT.
PERFORMANCE OF GLUCOMANNAN-ALGINATE COMBINATION AS A pH SENSITIVE EXCIPIENT OF VITAMIN C ENCAPSULATION USING GELATION METHOD
Authors: WARDHANI DYAH HESTI , CAHYONO HERI , ARYANTI NITA 
Published: March 2019

Objective: This research aimed to develop pH-sensitive vitamin C encapsulation using a combination of biodegradable glucomannan and alginate as an excipient.
Methods: Gelation of the excipient was developed by dropping the matrix into the CaCl2 solution to obtain beads. Various ratios of glucomannan-alginate (1:0, 1:1, 1:3, 3:1 and 0:1, g/g), vitamin C concentrations (1, 3 and 5% of total excipient) and excipient preparation methods (mixed glucomannan-alginate matrix, glucomannan beads coated with alginate and alginate beads coated with glucomannan) were selected as variables. Entrapment efficiency of encapsulation and the release of vitamin C were determined at pH 1.2 and 6.8 which represent the pH of the stomach and the small intestine liquid, respectively.
Results: Encapsulation of 3% vitamin C using 1:1 (g/g) glucomannan-alginate showed the most efficient matrix. This ratio also had lower released of vitamin C in pH 1.2 compared to that in pH 6.8. Coating the glucomannan bead with alginate showed better ability in encapsulating vitamin C. Combination excipient, as well as the addition of the vitamin C, increased the peak absorbance of the functional groups. The surface morphology of the encapsulation bead depended on the preparation method.
Conclusion: An equal ratio of glucomannan and alginate (1:1, g/g) which encapsulated 3% vitamin C showed the most efficient encapsulation as well as lower released vitamin C in pH 1.2 compared to that in pH 6.8. Higher efficiency was observed in encapsulating vitamin C using glucomannan which was coated with alginate.
FORMULATION STRATEGY, STABILITY ISSUES, SAFETY AND EFFICACY EVALUATIONS OF ACACIA CATECHU WHITENING CREAM
Authors: Anurukvorakun Oraphan , Lahpun Narongrit , Boonruang Rachadaporn 
Published: March 2019

Objective: To investigate among formulation strategy, stability issues, safety and efficacy (tyrosinase inhibitory activity and sun protection) of a novel whitening cream containing Acacia catechu heartwood extract.
Methods: The tyrosinase inhibitory activity of the A. catechu extract was investigated using L-DOPA as a substrate. A combination of silicone and three photo-protective filters; natural UV filter (A. catechu extract), chemical and physical filters, was formulated and evaluated. The Sun Protection Factor (SPF), stability, skin allergy or irritation, and the satisfaction of the developed whitening creams, were investigated.
Results: The A. catechu extract showed the strong tyrosinase inhibitory activity with the percentage of inhibition of 61.58% at the concentration of 120 mg/ml compared to a positive control of kojic acid (98.73 % inhibition) at the same concentration of 120 mg/ml. impressively, the highest SPF of A. catechu whitening cream with physical and chemical UV filters was 30. While, the highest SPF of the A. catechu whitening cream without those filters, was 24. No changes in color, liquefaction and phase separation were observed for the developed whitening cream when stored in the refrigerator. Among the twenty volunteers, eighteen volunteers had no skin irritation, while one of them had redness (Transient) and then another one had erythema or very slight irritation to the developed whitening creams. Besides, there was no statistically significant difference for the satisfaction between A. catechu whitening creams and commercial whitening creams (p>0.05).
Conclusion: Obviously, A. catechu whitening creams had very high efficacy, stability, and safety for being a commercial product in a near future.
DESIGN, CHARACTERIZATION AND STATISTICAL OPTIMIZATION OF RAMOSETRON HYDROCHLORIDE MOUTH DISSOLVING FILM USING DESIGN OF EXPERIMENT
Authors: BOBDE SUWARNA SURESH , TANK HEMRAJ M. 
Published: March 2019

Objective: The present study aims to prepare a mouth dissolving film of ramosetron hydrochloride to provide relief to cancer patients suffering from nausea and vomiting.
Methods: Mouth dissolving film of ramosetron hydrochloride were prepared and optimized using three levels two factor design. The films were prepared using the solvent casting technique. The effect of formulation variables such as the concentration of HPMC E15, and honey on disintegration time, tensile strength and drug release from the film were studied. The films were evaluated for weight, thickness, folding endurance, tensile strength, percent elongation, surface pH, disintegration time and drug release.
Results: All the films were found to be transparent, non-sticky and easily peelable. The concentration of HPMC E 15 and Honey was found to have a significant effect on disintegration time and drug release of the mouth dissolving film. Formulation R1 was found to the best formulation with 104.21 % release in 9 min and disintegration time of 57 seconds.
Conclusion: It can be concluded that the developed mouth dissolving film could serve as an effective, convenient alternative to prevent nausea and vomiting in cancer patients of any age group.
MICELLAR ENHANCED SYNCHRONOUS FLUORESCENCE FOR THE ASSAY OF SUMATRIPTAN SUCCINATE IN PHARMACEUTICAL TABLETS
Authors: FRAIHAT SAFWAN M. 
Published: March 2019

Objective: To develop a sensitive, fast and selective method for the determination of sumatriptan succinate (SUM) in pharmaceutical samples.
Methods: The method is based on measuring the synchronous fluorescence of SUM using ∆λ of (120 nm) and at a wavelength of excitation and emission of 230 and 325 nm respectively, using Agilent Technology, Cary eclipse, G9800AA model Luminescence spectrometer. Effect of variables on fluorescence emission intensities was studied such as solvent, surfactant, and pH. The proposed method was validated in term of linearity, limit of detection as per the international conference on harmonization guidelines ICH Q2 (R1).
Results: The linearity of the method was obtained with a wide range of (50-150) ng/ml with a high value of correlation coefficient value of (0.992). Limits of detection (LOD) and limits of quantitation (LOQ) were found to be 16.3 and 49.5 ng/ml respectively, the mean recovery was found to be 99.1% with low relative standard deviation (% RSD). The method was also compared statistically with the reference method using t-test and f-test, the results show no difference either in pure or pharmaceutical tablets.
Conclusion: The obtained results revealed that the developed method can be applied successfully for the determination of SUM in drug formulations samples with good accuracy and precision.
APPLICATION OF GRAPHENE OXIDE ON APTAMER-BASED BIOSENSOR DEVELOPMENT FOR AUTHENTICATION OF GELATIN
Authors: WIDADA HARI , ROHMAN ABDUL , JENIE RIRIS ISTIGHFARI , . SISMINDARI 
Published: March 2019

Objective: The objective of this study was to perform aptamer selection using systematic evolution of ligands by exponential enrichment (SELEX) method which assisted by graphene oxide against target of porcine gelatin (non-halal gelatin).
Methods: The aptamer selection was carried out using SELEX method without target immobilization. Selection of aptamer capable of binding porcine gelatin by applying grafen oxide (GO) was known as GO-SELEX. The selection process was initially carried out by incubation of single-stranded DNA (ssDNA) libraries targeting on porcine gelatin with the addition of graphene oxide. The selected ssDNA was then purified by several stages namely; symmetric PCR amplification, purification of products with DNA purification kits, asymmetric PCR amplification, and continued purification of DNA with native PAGE. The analysis of each stage was done by agarose gel electrophoresis.
Results: the results showed that aptamer targeting porcine DNA could be selected. This was indicated by the results of DNA analysis using native polyacrylamide gel electrophoresis (PAGE) in which sharp separation band with a base length equivalent to the marker of the ssDNA library (about 80 base pair) was obtained.
Conclusion: Aptamer targeting on porcine gelatin has been successfully developed using GO-SELEX method. GO can increase selectivity in developing aptamer which will be used as a biosensor to detect porcine gelatin. The method could be proposed as a standard of apatamer based method for porcine gelatin detection on halal products authentication.
THE RAPID AND GREEN HAIR ANALYSIS METHOD DEVELOPMENT USING FTIR FOR PAPAVERINE HCL DETERMINATION
Authors: NUGRAHANI ILMA , SULISTIANA STEPHANIE , IBRAHIM SLAMET 
Published: March 2019

Objective: This study was aimed to develop a rapid analysis using FTIR (Fourier Transform Infra-Red) for papaverine hydrochloride (HCl) determination in the hair sample, supported by a mathematically manipulation; which never been reported before in toxicology and forensic analysis.
Methods: Firstly, the method was checked its validity to ensure the feasibility for the quantitative purpose. The absorbance spectrums were collected by measure the drug, matrix, and its mixture. A spectra which showed the best specificity and linearity then was selected and derived. Afterwards, the area under the curve (AUC) was measured. A series of concentration was used for compose the calibration curve. Based on the result, some validation parameters were checked thoroughly. Further, for sample preparation, hair was collected non-invasively, then was decontaminated using soap. Next, it was immersed into a papaverine HCl solution at a concentration of 25 mg/ml along days. Finally, the amount of drugs absorbed were measured by the developed method using FTIR.
Results: Experimental data showed that all validation parameters could be fulfilled by the developed method. The selected spectra for the content determination was 1320-1230 cm-1. Its linearity was represented by a correlation coefficient value (r) ≥ 0.9999, variation coefficient (Vxo) ≤ 2.0%. The limit of detection (LOD) was 0.00618% w/w, meanwhile, the limit of quantitation (LOQ) was 0.02060% w/w, respectively. The percent recovery was in the range 97-103% with the relative standard deviation (RSD) was ≤ 2.0%. The drug has detected after 72 h immersion, moreover, after 192 h the concentration gained was 0.1594±0.0011% w/w.
Conclusion: As the conclusion, FTIR absorbance-derivative method is adequate as a rapid procedure for determine papaverine HCl in the hair sample. This method shows the appropriate of specificity, accuracy and precise. In addition, it shows the advantages of simplicity, green/eco-friendlier, and cost-efficiency.
A REFORMA DO ENSINO MÉDIO COMO MECANISMO DE INTENSIFICAÇÃO DO DUALISMO ESCOLAR
Authors: Esquinsani Rosimar Serena Siqueira , Esquinsani Valdocir Antonio 
Published: March 2019

Considerando a existência no Brasil, de um processo de dualismo escolar - do qual o Ensino Médio é um dos sintomas mais palpáveis -, o texto problematiza a organização curricular desta etapa da Educação Básica e as possibilidades dessa organização representar - após a Lei nº 13.415/2017 -, a intensificação desse dualismo. Amparado em uma pesquisa documental e bibliográfica, o texto conclui que o modelo que entrou em vigor após a chamada Reforma do Ensino Médio de 2017 legitima, na prática, dois projetos formativos: a formação propedêutica e/ou a formação para o mundo do trabalho, sendo que as recentes alterações legais não parecem colocar como horizonte a superação do dualismo escolar.