bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long Non-coding RNA MALAT1 Inhibits Neuron Apoptosis and Neuroinflammation While Stimulates Neurite Outgrowth and Its Correlation With MiR-125b Mediates PTGS2, CDK5 and FOXQ1 in Alzheimer's Disease
Authors: Ma Peizhi , Li Yuanlong , Zhang Wei , Fang Fengqin , Sun Jun , Liu Mingzhou , Li Kun , Dong Lingfang 
Published: August 2019

Background:
This study aimed to investigate the effect of long noncoding ribonucleic acids
(RNAs) metastasis-associated lung adenocarcinoma transcript 1 (lnc-MALAT1) on regulating neuron
apoptosis, neurite outgrowth and inflammation, and further explore its molecule mechanism in Alzheimer’s
disease (AD).

Methods:
Control overexpression, lnc-MALAT1 overexpression, control shRNA, and lnc-MALAT1
shRNA were transfected into NGF-stimulated PC12 cellular AD model and cellular AD model from
primary cerebral cortex neurons of rat embryo, which were established by Aβ1-42 insult. Rescue experiments
were performed by transferring lnc-MALAT1 overexpression and lnc-MALAT1 overexpression
& miR-125b overexpression plasmids. Neuron apoptosis, neurite outgrowth and inflammation were
detected by Hoechst-PI/apoptosis marker expressions, and observations were made using microscope
and RT-qPCR/Western blot assays. PTGS2, CDK5 and FOXQ1 expressions in rescue experiments were
also determined.

Results:
In two AD models, lnc-MALAT1 overexpression inhibited neuron apoptosis, promoted neurite
outgrowth, reduced IL-6 and TNF-α levels, and increased IL-10 level compared to control overexpression,
while lnc-MALAT1 knockdown promoted neuron apoptosis, repressed neurite outgrowth, elevated
IL-6 and TNF-α levels, but reduced IL-10 level compared to control shRNA. Additionally, lnc-
MALAT1 reversely regulated miR-125b expression, while miR-125b did not influence the lnc-
MALAT1 expression. Subsequently, rescue experiments revealed that miR-125b induced neuron apoptosis,
inhibited neurite outgrowth and promoted inflammation, also increased PTGS2 and CDK5
expressions but decreased FOXQ1 expression in lnc-MALAT1 overexpression treated AD models.

Conclusion:
Lnc-MALAT1 might interact with miR-125b to inhibit neuron apoptosis and inflammation
while promote neurite outgrowth in AD.
Asia Pacific Report: A New Zealand nonprofit journalism model for campus-based social justice media
Authors: Robie David 
Published: August 2019

For nine years, the Pacific Media Centre research and publication unit at Auckland University of Technology has published journalism with an ‘activist’ edge to its style of reportage raising issues of social justice in New Zealand’s regional backyard. It has achieved this through partnerships with progressive sections of news media and a nonprofit model of critical and challenging assignments for postgraduate students in the context of coups, civil war, climate change, human rights, sustainable development and neo-colonialism. An earlier Pacific Scoop venture (2009-2015) has morphed into an innovative venture for the digital era, Asia Pacific Report (APR) (http://asiapacificreport.nz/), launched in January 2016. Amid the current global climate of controversy over ‘fake news’ and a ‘war on truth’ and declining credibility among some mainstream media, the APR project has demonstrated on many occasions the value of independent niche media questioning and challenging mainstream agendas. In this article, a series of case studies examines how the collective experience of citizen journalism, digital engagement and an innovative public empowerment journalism course can develop a unique online publication. The article traverses some of the region’s thorny political and social issues—including the controversial police shootings of students in Papua New Guinea in June 2016.
Growth and Yield Response of Maize (Zea mays L.) on Acid Soil to Different Rates of Humic Acid and NPK Fertilizer
Authors: Wulandari Putri , Sulistyaningsih Endang , Handayani Suci , Purwanto Benito Heru 
Published: August 2019

The main constraint in the extensification of maize on the dry land of acid soil is the low availability of P in soil. This study aimed to determine the effect and the optimal dose of humic acid on the growth and yield of maize on acid soil. This research was conducted from February to May 2017 at Tri Dharma Field Laboratory, Faculty of Agriculture, Gadjah Mada University. Acid soil with low P availability used was from sub-district Cigudeg and Jasinga, West Java. The research was arranged in Randomized Complete Block Design (RCBD) with 2 factors. The first factor was maize cultivar, namely Bisi 2 and Pioneer 35. The second factor was the rate of humic acid and NPK fertilizer, consisting of 0 kg.ha-1 (without) NPK and 0% (without) humic acid, NPK + 0% (without) humic acid, NPK + 5% humic acid, NPK + 10% humic acid, and NPK + 15% humic acid. NPK fertilizer applied was NPK 16:16:16 at a dose of 350 kg.ha-1. The results showed that humic acid application on acid soil increased C-humic content in the soil, soil P availability, total dry weight of the plant, and kernel dry weight at harvest (15 weeks after planting). The increase in soil P availability did not improve the plant growth but increased the accumulation of plant biomass. The application of humic acid at 15% (52.5 kg.ha-1) combined with NPK fertilizer on acid soil significantly increased total dry weight of plant and kernel dry weight up to 13.14% and 21.81%, respectively, thus, it is recommended for maize cultivation on acid soil.
Genetic Diversity of Croton (Codiaeum variegatum (L.) Rumph.ex A. Juss) and Its Offspring Based on RAPD Markers
Authors: Asniawati Mufit Daryatun , Purwantoro Aziz 
Published: August 2019

Croton (Puring) is a native plant of Indonesia which has varied leaf shapes and colors. The diversity of croton increase through hybridization. The information on genetic diversity and relationship between parent and its offspring of crotons is very limited. This study aims to analyze the genetic diversity of cultivar Mawar (MW) and Walet (W) as parent compare to their offspring i.e, Black Marlet (BM), Kingkit 1 (KA), Kingkit 2 (KB), and Kamaratih (KM) using RAPD markers. This study used DNA extraction from the fresh leaf of six cultivars. The next steps were DNA quantification, primary optimization, DNA amplification with PCR, and electrophoresis. Statistical analysis was carried out using Genalex software. A total of 40 primers were screened, out of which 10 were selected for the analysis of genetic diversity. A total of 106 polymorphic bands were generated, ranging from 130 to 1850 bp. The results of RAPD analysis showed that Mawar as female parent had the highest polymorphic bands percentage of 69.01%, while Walet as male parent and its offspring ranged from 31.15 % to 43.94%. The genetic distance of the offspring with Walet ranged from 0.176 to 0.234 and genetic distance of the offspring with Mawar ranged from 0.314 to 0.372. It was indicated that all of offspring were closer to the male parent.
Terminal Pleistocene lithic variability in the Western Negev (Israel): Is there any evidence for contacts with the Nile Valley?
Authors: Leplongeon Alice , Goring-Morris A. Nigel 
Published: August 2019

At the end of the Pleistocene (25,000-15,000 BP), there is a shift to more arid conditions in the Negev and the Sinai corresponding to the Last Glacial Maximum. For the Nile Valley and the Levant, the lowering of the Mediterranean sea level, the expansion of the Sahara and the desiccation of some major eastern African lakes had important consequences on: (1) the general behaviour of the River Nile; (2) the landscape around the Nile Delta; and (3) sand dune mobilisation. Despite this shift to more arid conditions, there is abundant evidence for human occupation in the Egyptian Nile Valley and in the arid zone of the Southern Levant at this time. In addition, contacts between these two regions have sometimes been suggested, mainly by genetic studies, including early ‘Back-to-Africa’ dispersals.
This paper focuses on the analysis of six terminal Pleistocene (ca. 25,000-15,000 BP) lithic assemblages from the western Negev Desert dunes in Israel, attributed to the Early and Middle Epipalaeolithic. The analysis relies on the chaîne opératoire approach combined with attribute analysis that enables quantification of typo-technological differences. Results of this analysis allows comparisons with assemblages from the Egyptian Nile Valley analysed in the same way previously. This comparative analysis is then used to discuss hypotheses of potential technical diffusions between these two regions. Current archaeological evidence therefore does not support any contacts between populations between the Levant and the Nile Valley at the end of the Pleistocene.
Middle Palaeolithic lithic tools: Techno-functional and use-wear analysis of target objects from SU 13 at the Oscurusciuto rock shelter, Southern Italy
Authors: Marciani Giulia , Arrighi Simona , Aureli Daniele , Spagnolo Vincenzo , Boscato Paolo , Ronchitelli Annamaria 
Published: August 2019

The Oscurusciuto rock shelter (Ginosa, Puglia, southern Italy) is a Middle Palaeolithic site characterized by a significant stratigraphy made up by several anthropic levels. The stratigraphic unit 13, consisting of a sandy compact deposit mixed with pyroclastic sediment, is a short palimpsest situated on a layer of tephra, identified as Mt. Epomeo green tuff (dated Ar/Ar ~ 55 ka BP).
From a technological point of view, the aims of the production were backed flakes, convergent flakes, and other flakes obtained by means of a Levallois debitage, plus (less represented) bladelets produced by an additional volumetric reduction system.
Our aim in this research was to examine a selection of the above-mentioned target objects produced by debitage in order to understand the manufacture and life-cycle of each single tool from a dynamic perspective.
We integrated techno-functional and use-wear analyses: the first was implemented to globally comprehend each tool, identifying each single techno-functional unity (prehensile and transformative portions), whereas the second revealed the way in which these tools had been used, proceeding to identify the activity involved (e.g., piercing, cutting and/or scraping), and the type of material (vegetable/animal, soft/hard) on which these activities had been carried out.
The combined use of these two approaches allows us to ascertain the intention of the prehistoric craftsmen, the gestures and procedures involved in making the tools, and the way they had been used. From one single object we are thus able to reconstruct a series of complex behaviours, encompassing the creation, the life-cycle and finally the ‘death’ or repurposing of the tool in question.
Culture versus Structure: A Critical Perspective on the Role of Culture in Tax Evasion
Authors: Hutchinson Robert 
Published: August 2019

ABSTRACT
Culture is a somewhat nebulous term, particularly in the context of accounting scholarship. Historically, it has been offered as a factor to explain many economic phenomena, including tax evasion. Utilizing Hofstede's (1980, 2001) cultural dimensions and data from the World Bank from 2005–2010, this study takes an exploratory approach to develop a stepwise, forward selection regression model to better illuminate this phenomenon vis-à-vis culture and economic structure. The results suggest, at least within the context of tax evasion, that cultural indices may be redundant in the presence of other readily available socio-economic indicators. This brings the age-old debate of culture versus structure to the forefront of accounting scholarship and policymaking.
Heterogeneity of Treatment Effects From an Intensive Lifestyle Weight Loss Intervention on Cardiovascular Events in Patients With Type 2 Diabetes: Data From the Look AHEAD Trial
Authors: de Vries Tamar I. , Dorresteijn Jannick A.N. , van der Graaf Yolanda , Visseren Frank L.J. , Westerink Jan 
Published: August 2019

OBJECTIVETo explore the presence of heterogeneity of treatment effect (HTE) of an intensive lifestyle intervention on the occurrence of major cardiovascular events (MACE) in overweight or obese patients with type 2 diabetes, and to identify patient characteristics associated with individual treatment effect.RESEARCH DESIGN AND METHODSIn 4,901 participants from the Action for Health in Diabetes (Look AHEAD) trial, a penalized Cox regression model to predict treatment effect of intensive lifestyle intervention for the risk of MACE was derived, including all possible treatment-by-covariate interaction terms. The ability of the model to predict HTE was confirmed by calculating hazard ratios (HRs) and absolute risk change in quartiles of predicted treatment effect, and baseline patient characteristics were compared between quartiles.RESULTSIn quartile 1 of predicted treatment effect, with the highest predicted risk reduction, there was a significant treatment benefit of intensive lifestyle intervention (HR 0.64 [95% CI 0.49–0.83]), whereas there was no effect from treatment in quartiles 2 and 3 (HR 0.81 [95% CI 0.58–1.14] and 1.13 [95% CI 0.80–1.60], respectively) and a detrimental effect in quartile 4 (HR 1.37 [95% CI 1.09–1.73]). Several patient characteristics in demographics, medical history, physical examination, and laboratory values were associated with the level of treatment effect.CONCLUSIONSThis post hoc analysis of the Look AHEAD trial showed that an intensive lifestyle intervention aimed at weight loss may reduce cardiovascular events in selected patients but may have a detrimental treatment effect in others.
New Spectrophotometric Determination of Cefdinir by Batch Method and Cloud Point Extraction
Authors: Mezhir Omar qusay 
Published: August 2019

In this study, new spectrophotometric methods were developed for estimation of cefdinir (CFD); the research consists of two methods. The first method depends on the conversion of function group amine in cefdinir to diazonium salt and then combined with the 2, 5-Dimethylphenol (2, 5-DMP) reagent in the alkaline medium. The formed azo dye has a purple colour with absorption intensity at λmax 510 nm. Concentration range was obeyed Beer's law at (1-50 μg / ml), correlation coefficient was 0.9998, molar absorptivity was 1.54 × 104 L.mol-1.cm-1 and the detection limit was 0.04 μg.ml-1. The second method is including cloud point extraction (CPE) of a trace amount of the formed azo dye in the first method followed by measuring with a UV-visible spectrophotometer. Concentration range that obeyed the Beer's law was (0.2-6 μg / ml), correlation coefficient was 0.9998, molar absorptivity was1.48×105 L.mol-1.cm-1, detection limit was 0.004 μg.ml-1, Pre-concentration factor was 25 and Distribution coefficient was 125.The proposed methods were applied and proved their compatibility for estimating of ingredient compound in pure samples and pharmaceuticals by comparing them with previous studies.
Keyword: cefdinir, diazotization, cloud point extraction, 2, 5-Dimethylphenol.
EFEKTIVITAS SOSIALISASI PENCEGAHAN KEBAKARAN HUTAN DAN LAHAN PADA MASYARAKAT DI DESA SUNGAI BULUH KECAMATAN BUNUT KABUPATEN PELALAWAN RIAU
Authors: Nurdin Nurdin , Badri Muhammad , Sukartik Dewi 
Published: August 2019

Sosialisasi pencegahan kebakaran hutan dan lahan di Desa Sungai Buluh Kecamatan Bunut Kabupaten Pelalawan dinilai belum efektif. Hal ini terbukti bahwa masyarakat di Desa Sungai Buluh belum memahami secara detail tentang aturan membakar hutan dan lahan. Masyarakat hanya paham kalau membakar hutan dan lahan bisa masuk penjara. Penelitian tentang efektivitas sosialisasi pencegahan Kebakaran Hutan dan Lahan (Karhutla) adalah untuk mengetahui pengaruh kegiatan sosialisasi yang dilakukan pemerintah, swasta dan LSM terhadap pemahaman, motivasi dan tindakan masyarakat dalam proses pencegahan Karhutla di Desa Sungai Buluh Kecamatan Bunut Kabupaten Pelalawan. Kajian ini menggunakan pendekatan positivisme dan konstruktivisme, dikuatkan dengan teori sosialisasi.Teknik pengumpulan data menggunakan angket, FGD, dan wawancara. Hasil penelitian menemukan sosialisasi yang dilaksanakan pemerintah, swasta dan LSM kepada masyarakat di Desa Sungai Buluh Kecamatan Bunut belum berjalan dengan efektif. Namun, kegiatan sosialisasi mempengaruhi pengetahuan dan tindakan masyarakat secara signifikan pada kegiatan pencegahan Karhutla, akan tetapi kegiatan sosialisasi tidak mempengaruhi motivasi masyarakat secara signifikan. Hal ini disebabkan kegiatan sosialisasi hanya dihadiri perwakilan aparatur desa tidak langsung kepada masyarakat secara keseluruhan.
PENGARUH ACARA FESTIVAL SENI TERHADAP CITRA SEKOLAH DI SMA NEGERI 06 PEKANBARU
Authors: Idawati Idawati 
Published: August 2019

Tujuan dari penelitian ini adalah (1) untuk mengetahui bagaimana pengaruh acara festival seni terhadap siswa, (2) untuk mengetahui bagaimana pandangan siswa terhadap citra sekolah, (3) untuk mengetahui bagaimana acara festival seni terhadap citra sekolah. Metode yang digunakan dalam penelitian ini adalah pendekatan analisis kuantitatif data hasil pengukurannya merupakan data kualitatif yang diangkakan atau diskor. Populasi dalam penelitian ini adalah seluruh siswa SMA Negeri 06 mulai dari kelas X s/d kelas XII berjumlah 1201 orang. Dalam penelitian ini tekhnik pengambilan sampel dilakukan dengan cara random sampling, sampel dalam penelitian ini menggunakan rumus Slovin. Jadi sampel dalam penelitian ini berjumlah 120 orang siswa. Teknik pengumpulan data dalam penelitian ini yaitu: kuesioner, wawacara, dokumentasi, studi pustaka. Dalam penelitian ini, peneliti menggunakan skala pengukuran adalah skala likert (liket scale) yang digunakan untuk mengukur sikap, pendapat, persepsi, seseorang tentang suatu kejadian atau gejala sosial. Teknik analisa data dalam penelitian ini yaitu: menggunakan teknik analisis data regresi sederhana. Hasil penelitian ini yaitu (1) Bentuk pelaksanaan kegiatan festival seni di SMAN6 sangat tersusun dan terencana dengan baik, sehingga hal ini menyebabkan SMAN6 dalam melaksanakan kegiatan selalu berhasil dan mendapat sambutan positif bagi peminatnya, (2) Citra SMAN6 dimata siswa cukup baik dan sangat sangat positif ditandai dari rekapitulasi jawaban responden yang menjawab sangat setuju tentang kegiatan positif yang dilaksanakan oleh SMAN6 melalui kegiatan festival seni, (3) Pengaruh acara festival seni terhadp citra SMAN6 sangat berpengaruh signifikan hal ini dibuktikan dari hasil regresi linier sederhana.
KOMUNIKASI ANTAR BUDAYA PADA KOMUNITAS PERCA (STUDI FENOMENOLOGI)
Authors: Rosalyn Maria Eva , Kuncoroyakti Yohanes Arie 
Published: August 2019

Penelitian ini dilakukan untuk melihat komunikasi antar budaya yang terjadi dalam pasangan yang tergabung dalam komunitas PerCa Indonesia, khususnya di wilayah Jabodetabek. Metode penelitian yang dilakukan adalah metode kualitatif dengan fenomenologi komunikasi sebagai dasar penelitian. Komunitas PerCa merupakan komunitas yang beranggotakan pasangan dengan kewarganegaan yang berbeda. Perbedaan budaya yang ada dalam komunitas pasangan suami istri bukan menjadi hal terpenting dalam komunikasi melainkan sikap untuk saling memahami dan menerima. Kemampuan inilah yang seringkali dilakukan oleh pasangan dan menjadikan kebiasaan. Penelitian ini juga melihat bahwa komunikasi budaya yang terjadi diantara pasangan tersebut menimbulkan sebuah komunikasi transaksional, Selain itu muncul juga sebuah budaya baru yang dihasilkan. Budaya baru tersebut terbentuk karena budaya dari salah satu pasangan menjadi lebih dominan, hal tersebut tidak mempengaruhi relasi yang terjadi diantara mereka.
PRINCIPLE OF JUSTIFICATION IN THE USAGE OF IONIZING RADIATION IN MEDICINE: INTERNATIONAL NORMATIVE PROBLEMS
Authors: Ilyin N. Yu. , Borodina A. A. 
Published: August 2019

INTRODUCTION. The article deals with one of the principles of the usage of ionizing radiation in medicine – the principle of justification. The authors study the content and the legal consolidation of the principle of justification in the Standards of the IAEA, Russia and the European Union law. The particular attention is paid to the practical application of the principle.MATERIALS AND METHODS. The subject matter for the study wеre the regulations and standards of the IAEA, legislation of Russia and the EU concerning the usage of ionizing radiation in medicine; proceedings materials of the International conference on radiation protection in medicine (2017); scientific publications of the researchers from Russia and the EU dealing with the standards of the IAEA. The methodology of the study is based on the general and specific methods of cognition.RESEARCH RESULTS. As a result of the conducted research the authors come to the conclusion about the need to add the current legislation concerning the principle of justification, and offer a list of specific recommendations in order to get the problem over.DISCUSSION ANDCONCLUSIONS. The authors come to the conclusion that there are some problems in the international and national law dealing with the principle of justification. In order to solve the problems and correct a legal deficiency the authors offer the specific measures including taking into account the meaning of law enforcement practice for the subjects of national law and order: medical workers and patients.
Effective assimilation of technological innovation in an organization characterized ?as a Complex Adaptive System
Authors: Hagsall Alon E. , Ahituv Niv , Naveh Nili 
Published: August 2019

Purpose: Most organizations seek for innovative solutions to address tabulate changes and competition. However, each organization is required for rapid and effective processes of assimilating technological innovation into its operational activities. Consistent with previous studies, the aim of this study was to understand whether an organization characterized as CAS (Complex Adaptive System) could positively affect the process of assimilating technological innovation through supporting the development of knowledge workers. Such workers deal mostly with changes. Hence, they possess the ability to combine personal benefits with organizational goals, they are sensible to changes in the environment, they understand the integration of information required for such a process, and they need the ability to socialize among themselves.
Design/methodology/approach: A sample of 300 employees in organizations of different sectors responded to an online questionnaire, which examined their attitude towards technological innovation in correlation with the level of organization's CAS characteristics. Pearson and regression analyses were used to examine the relationships between the functioning of the workers as CAS fractals[1] and their attitudes toward the process of assimilation of technological innovation.
Findings: Workers who function as “fractals”, namely as knowledge-worker in organizations having the characteristics of CAS, were able to combine personal benefits with organizational goals. They had sensitivity to changes in the environment, integration of the information required for the process and the ability to socialize among themselves. These abilities of knowledge workers have significantly influenced the development of positive attitudes towards the process of assimilation of technological innovation, a better understanding of the technology and the advantages they gain from it, which make them ready to be involved in the process.
Practical implications: The practical contribution of this study is the ability to best portray the characteristics of an optimal work environment in an organization that wishes to undergo assimilation processes, technological innovation, management and dissemination of relevant knowledge for the organization's use. Such an organization is required to provide its employees with a degree of operational autonomy enabling them to interweave personal interests and organizational goals, and to be involved and to influence the processes of assimilating technological innovation in the organization. The organization should also maintain a high level of updating, transparency, and transfer of knowledge from outside into the organization. In addition, investment in information systems for the information integration provides the employees with the possibility of social networking during their work.