bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Genetic structure and sodium channel gene mutation analysis related to pyrethroid insecticide toxicity in sylvatic Andean Triatoma infestans from Bolivia”
Authors: Marcet Paula L. , Santo-Orihuela Pablo , Messenger Louisa A. , Vassena Claudia V. 
Published: January 2019

ABSTRACTBACKGROUNDSylvatic populations of Triatoma infestans represent a challenge for vector control as these populations are not targeted by control activities and could play a key role in post-spraying house re-infestation. Improved understanding of sylvatic foci, population distribution, dispersion patterns, gene flow between sylvatic and domestic populations, as well as characterization of insecticide resistance profiles, is crucial to optimize vector control interventions.METHODSWe analyzed the genetic relationship of five Andean populations from Bolivia from localities with distinct insecticide susceptibility profiles (sylvatic: 20 de Octubre, Illicuni, Kirus Mayu and Mataral and one domestic from Mataral). Individual multilocus genotypes based on 8 microsatellites and the DNA sequence of a fragment of the cytochrome B (cytB) gene were obtained for 92 individuals. We compared the cytB haplotypes with previously reported Andean T. infestans haplotypes and evaluated the directionality and possibly history of gene flow among populations. Each specimen was screened for 2 nucleotide mutations (L1014 and L9251) of the sodium channel gene (kdr), described for T. infestans and related to pyrethroid resistance.RESULTSSignificant genetic differentiation was observed among all populations, reflecting current genetic isolation among them. However, individuals of admixed origin were detected in four populations, especially between the sylvatic and domestic populations from Mataral. Historical analysis of gene flow suggests that insecticide resistance is conferred by ancient trait(s) in T. infestans sylvatic populations that are capable of invading domiciles. The kdr mutation L1014 was identified in one individual from Mataral, while the L9251 mutation was not detected in any population. The low frequency of kdr mutations in these populations suggests this mechanism is unlikely to be the primary cause of the observed altered insecticide susceptibility. However, the resistance conferring mutation is present in the area and with the potential to be selected under insecticidal pressure.CONCLUSIONSThese results emphasize the need for stronger entomological surveillance in the region, including early detection of house invasion, particularly post-spraying, monitoring for resistance to pyrethroids and the design of integrative control actions that consider both sylvatic foci around domestic settings as well as the bug dispersion dynamics.
REC8-cohesin, chromatin and transcription orchestrate meiotic recombination in the Arabidopsis genome
Authors: Lambing Christophe , Tock Andrew J. , Choi Kyuha , Topp Stephanie D. , Kuo Pallas C. , Blackwell Alexander R. , Zhao Xiaohui , Osman Kim , Higgins James D. , Franklin F. Chris H. , Henderson Ian R. 
Published: January 2019

AbstractDuring meiosis chromosomes undergo DNA double-strand breaks (DSBs) that can be repaired using a homolog to produce crossovers, which creates genetic diversity. Meiotic recombination occurs coincident with homolog pairing and polymerization of the meiotic axis and synaptonemal complex (SC). REC8-cohesin is required to connect chromosomes to the axis and to organize axis polymerization. However, control of REC8 loading along chromosomes, in relation to chromatin, transcription and recombination, is not yet fully understood. Therefore, we performed REC8 ChIP-seq in Arabidopsis, which revealed strong enrichment in centromeric heterochromatin. REC8 abundance correlates with suppression of meiotic DSBs and crossovers, despite axis loading of SPO11-1 in these regions. Loss of the heterochromatic marks H3K9me2 and non-CG DNA methylation in kyp/suvh4 suvh5 suvh6 mutants causes remodeling of REC8 and gain of meiotic recombination locally in repeated sequences, although centromere cohesion is maintained. In the chromosome arms, REC8 is enriched within gene bodies, exons and GC-rich sequences, and anti-correlates with transcription. Highest REC8 occupancy occurred in facultatively silent, H3K27me3-modified genes. Using immunocytology we show that axis polycomplexes form in rec8 mutants that recruit recombination foci with altered stoichiometry, leading to catastrophic non-homologous recombination. Therefore, REC8 plays a key role organizing meiotic chromosome architecture and promoting high-fidelity interhomolog recombination. Despite this pro-recombination role, local REC8 enrichment associates with DSB repression at the fine scale, which is consistent with the tethered-loop/axis model. Coincident with its organizational role during meiosis, REC8-cohesin occupancy along the chromosomes is shaped by multiple chromatin states and transcription.
Explaining success of performance management systems
Authors: Laitinen Erkki K. , Kadak Tarmo 
Published: January 2019

PurposeThe purpose of this paper is to use the logical chain of key factors (KFs) to explain the success of performance management systems (PMS) and corporate performance.Design/methodology/approachThe authors use the strength of the KFs chain to capture PMS success. First, the authors assume that perceived environmental uncertainty (PEU) is positively associated with the strength (H1). The higher the PEU, the stronger is the chain as a response to uncertainty. Second, the authors assume that the strength improves performance (H2) but third, that the impact of the strength is negatively moderated by competition (H3). Fourth, the authors assume that this improvement leads to superior corporate performance (H4). The research model is tested by applying the partial least squares method for a sample of 61 Estonian and Finnish firms.FindingsEmpirical evidence shows that PEU is negatively correlated to the strength of the chain but when controlled for a set of control variables, the path coefficient is positive. The strength of the chain is positively associated with improvement in performance. The impact of the strength of the chain on financial performance is negatively moderated by competition. The improvement in performance is positively associated with the attainment level of strategic goals. The improvement in non-financial performance does not significantly affect corporate profitability.Practical implicationsThe levels of PEU and competition should be taken into the account when designing, adjusting and assessing the PMS of organization.Originality/valueThe authors give explanation why evidence about the effects of PMS on the performance of the firm is mixed.
Mos Geometricus and the Common Law Mind: Interrogating Contract Theory
Authors: Swaminathan Shivprasad 
Published: January 2019

AbstractEuclidian theories have it that there exist one or a small number of apex principles from which the entire fasciculus of rules of contract law can be logically deduced. Two arguments are marshalled against the Euclidian project. First, that it has been unsuccessfully attempted before – in the form of the nineteenth century contract law treatise which emulated the civil lawyer's rationalistic model, mos geometricus – cautioning us against setting much store by its present reincarnation. Second, that the common law's methodology makes it resistant to this form of theorising. Euclidian theory presupposes a picture of rules on which: a) cases involve an application of logically prior rules; b) rules are reliably identifiable by different actors in the legal system; and c) rules normatively range over an indefinite spectrum of future cases. It will be argued that the common law defies this picture of rules thus rendering Euclidian theory analytically impossible.
UK Abortion Law: Reform Proposals, Private Members’ Bills, Devolution and the Role of the Courts
Authors: Taylor Robert Brett , Wilson Adelyn L.M. 
Published: January 2019

AbstractUK abortion law remains unsettled, and subject to on‐going controversy and reform. This article offers a comprehensive critique of all reforms implemented or proposed since 2016. It examines reforms proposed in both Houses of Parliament and contextualises them within a public law analysis, showing both that the complex parliamentary processes relating to Private Members’ Bills have frustrated reform attempts, and that these attempts have been contradictory in their aims between the two Houses. Secondly, it examines the unique positions of Northern Ireland, Scotland and Wales to show the extent to which devolutionary settlements have influenced both reforms and executive involvement. Finally, it examines the potential impact of the courts on abortion law following Re Northern Ireland Human Rights Commission's Application for Judicial Review, showing that the Supreme Court's reframing of the debate in human rights terms is likely to affect abortion law, not only in Northern Ireland, but in the whole of the UK.
897. SYMPHYOTRICHUM VAHLII
Authors: Hind Nicholas , Strange Kit 
Published: January 2019

SummarySymphyotrichum vahlii (Gaudich.) G. L. Nesom (Compositae: Astereae: Symphyotrichinae) is described and illustrated, and the species is provided with an expanded synonymy that includes type citations, known types, and supplementary comments. Notes are provided on cultivation and propagation. Comments are also made on the historical collections representing this species, both as types and early collections, and relating these to early circumnavigations. The likelihood that Thinobia araucana Phil., of the monotypic Thinobia Phil., is this species is also discussed.
898. HELICHRYSUM ‘SUN BURST’
Authors: Strange Kit , Hind Nicholas 
Published: January 2019

SummaryA new cultivar, Helichrysum ‘Sun Burst’ (Compositae: Inuleae: Gnaphaliinae), is introduced, described, and illustrated, based on material derived from a cross between a Turkish collection of H. orientale and H. arwae from the Yemen Arab Republic, growing in the Melon Yard, Alpine Nursery at the Royal Botanic Gardens, Kew. Cultivation and propagation notes are provided. Observations on the diurnal rhythm of the capitula are made, as well as the overlapping flowering time of the parent species in the wild, but possessing a significantly different geographical distribution.
899. ECHINACEA TENNESSEENSIS
Authors: Hind Nicholas 
Published: January 2019

SummaryEchinacea tennesseensis (Beadle) Small (Compositae: Heliantheae: Ziniinae) is described and illustrated, and is accompanied by statements on its distribution, habitat, phenology, etymology and vernacular names. A statement on its conservation status is made. A brief history of Echinacea is provided, with a commentary of the most useful revision discussed. The subtribal position and related genera of Echinacea is discussed, with the most recent account proposing that Echinacea is placed in the subtribe Zinniinae, alongside Zinnia, Sanvitalia and Heliopsis, amongst others, and quite separate from Rudbeckia and Ratibida, with which it has often been allied, now placed in the subtribe Rudbeckiinae.
900. RUDBECKIA MAXIMA
Authors: Hind Nicholas 
Published: January 2019

SummaryRudbeckia maxima Nutt. (Compositae: Heliantheae: Rudbeckiinae) is described and illustrated. Cultivation, propagation and availability notes are provided. The genus Rudbeckia is discussed, and the position of R. maxima commented on, as well as the somewhat unique key character (the reflectiveness of the leaves under UV light) that has been used to distinguish this and two other species. The relationships of Rudbeckia within the tribe Heliantheae are discussed, especially amongst the other coneflowers. The epappose nature of the achene is discussed. It is considered similar to the situation found in Echinacea tennesseensis: the achene is covered in a dark brown corky layer, over the black phytomelanin layer, and extends above the apex of the achene forming a cupule, within which the dilated base of the disc floret corolla sits.
Blue, Green, and Grey Water Quantification Approaches: A Bibliometric and Literature Review
Authors: Mubako Stanley T. 
Published: January 2019

AbstractAn array of methodologies to quantify blue, green, and grey water have emerged in recent years and are still evolving rapidly, as are efforts to come up with reliable indicators of human appropriation of freshwater resources. This study provides an overview of recent blue, green, and grey water quantification approaches by analyzing publications extracted from the Web of Science database utilizing the Network Analysis Interface for Literature Studies (NAILS) bibliometric analysis tool, covering the period 2000–2018. A steep increase in the number of blue, green, and grey water publications was observed from the year 2009, with the United States and China among the top contributing nations. Blue, green, and grey water quantification approaches used in the analyzed publications were broadly categorized into Water Footprint Assessment, Life Cycle Assessment, and Hybrid methodologies. The Water Footprint Network was the most influential hub in terms of providing the most productive and cited authors. “Water footprint” and “virtual water” were unsurprisingly the trendiest and most cited keywords associated with the sample of analyzed publications. The study provides important insights that are helpful in understanding the diversity of techniques that have been applied to quantify blue, green, and grey water in recent assessment studies.
Grey Water: Agricultural Use of Reclaimed Water in California
Authors: Sheikh Bahman , Nelson Kara L. , Haddad Brent , Thebo Anne 
Published: January 2019

AbstractPotential for use of recycled water is great, especially for agricultural irrigation, which comprises by far the highest percentage of water taken from developed sources in the arid and semi‐arid regions of the world. In California, 80% of developed water is used for agriculture, and the same pattern prevails throughout the western United States. The potential for recycled water use in agriculture remains under‐realized because of numerous impediments. Understanding how the incentives and impediments to agricultural reuse vary based on local context is critical to understanding the tradeoffs and technology requirements for different end uses of recycled water. Public perceptions about the safety of reclaimed water (from human waste) were a major impediment to water recycling until recent years. Several pioneers of water recycling have demonstrated—as specialists in the field of social psychology have hypothesized—that these attitudes are ephemeral and can be changed with proper outreach, demonstration, and education.Another impediment is the regulatory structure in some states. Water rights issues are another impediment specific to some western states in the United States. Cost differences for delivered water from traditional sources versus recycled water can be another challenge potentially requiring financial incentives in the interest of the greater good. One other impediment to the use of recycled water for agricultural irrigation is competition with other demands for the same water—landscape, golf course, industrial, and potable reuse. Potential for increased use of recycled water is great if impediments are removed and incentives are provided at the local, state, and/or federal levels to close the gaps (geographic and otherwise) between the utilities and the farmers.
Impact of preadmission anti‐inflammatory drug use on the risk of RBC transfusion in elderly hip fracture patients: a Danish nationwide cohort study, 2005–2016
Authors: Glassou Eva N. , Kristensen Nickolaj , Møller Bjarne K. , Erikstrup Christian , Hansen Torben B. , Pedersen Alma B. 
Published: January 2019

BACKGROUNDDo prescription drugs with anti‐inflammatory properties such as nonsteroidal anti‐inflammatory drugs (NSAIDs), corticosteroids, and statins increase the risk of postoperative bleeding measured with RBC transfusion in elderly hip fracture surgery patients?STUDY DESIGN AND METHODSUsing the Danish Multidisciplinary Hip Fracture Database, 74,791 patients aged 65 years or older with surgery‐treated hip fracture were identified during 2005–2016, and their use of NSAIDs, corticosteroids, and statins was ascertained. For each drug, patients were categorized as nonusers (no prescription ≤365 days prior to surgery), former users (one prescription 91–365 days), and current users (one prescription ≤90 days). Information on surgical treatment, transfusion, other medication and comorbidities were collected using Danish nationwide registries. A log‐binomial model was used to estimate relative risks for RBC transfusion within 7 days of surgery and corresponding 95% confidence intervals. Adjustments were made for patient‐ and surgery‐related factors.RESULTSFormer and current users of NSAIDs, corticosteroids, and statins accounted for 22%, 10%, and 24%, respectively. Current users of NSAIDs had an increased adjusted relative risk of transfusion (1.07; confidence interval, 1.04–1.10) compared to nonusers. There was no association between current users of corticosteroids and statins and risk of transfusion.CONCLUSIONNSAID use within 90 days of a hip fracture surgery was associated with an increased risk of RBC transfusion. Thus, current use of NSAIDs can be associated with an increased risk of postoperative bleeding, but we cannot rule out the influence of confounding.
Stored red blood cells enhance in vivo migration of dendritic cells by promoting reactive oxygen species–induced cytoskeletal rearrangement
Authors: Zhao Man , Zhou Qianqian , He Chulin , Zhang Yulong , Wang Zhengjun , Cai Ruiying , Ma Cong , Li Yuan , Wang Xiaohui , Zhan Linsheng 
Published: January 2019

BACKGROUNDA complex array of physicochemical changes occurs in red blood cells (RBCs) during storage, leading to enhanced posttransfusion clearance. Dendritic cells (DCs) play crucial roles in the engulfment of aged RBCs; however, it is unclear how stored RBCs (sRBCs) modulate their responses to inflammatory stimuli and DC migration ability.STUDY DESIGN AND METHODSIn this study, we examined whether sRBCs affect the migration ability of DCs and elucidated the detailed mechanisms mediating this process. Murine RBCs were incubated with marrow DCs after removing the storage supernatant. The effects of sRBCs on cytokine secretion from DCs, surface marker expression, and homing ability were examined.RESULTSMore sRBCs were internalized by DCs than fresh RBCs (fRBCs), and RBC accumulation significantly promoted the expression of allostimulatory molecules and the secretion of Th1‐type cytokines in the presence of lipopolysaccharide (LPS). In particular, the lymphoid‐tissue homing ability of transfused DCs treated with sRBCs (sRBC‐DCs) was also significantly greater than that of fRBCs. Up regulation of CCR7 and improved organization of the cytoskeleton were observed in sRBC‐DCs, and blocking Rho/Rho‐associated protein kinase (ROCK), PI3K/Akt, and NF‐κB pathways greatly hindered cytoskeletal rearrangement. Moreover, high levels of reactive oxygen species (ROS) were detected in sRBC‐DCs, and treatment with N‐acetylcysteine simultaneously decreased the lymph node–homing ability of DCs and phosphorylation of RhoA, ROCK1, and cortactin.CONCLUSIONSsRBCs initiated differential immune responses compared to fRBCs, and the presence of LPS augmented this phenomenon. Up regulation of CCR7 and ROS production promotes cytoskeletal reorganization and contributes to the increased homing of sRBCs‐DCs.
EduCan trial: study protocol for a randomised controlled trial on the effectiveness of pain neuroscience education after breast cancer surgery on pain, physical, emotional and work-related functioning
Authors: De Groef An , Devoogdt Nele , Van der Gucht Elien , Dams Lore , Bernar Koen , Godderis Lode , Morlion Bart , Moloney Niamh , Smeets Ann , Van Wilgen Paul , Meeus Mira 
Published: January 2019

IntroductionOver the past decades, awareness on the importance of educational interventions in cancer pain management has increased. However, education is often restricted to biomedical pain management instructions. A more modern educational approach, also known as pain neuroscience education (PNE), explains pain from a biopsychosocial perspective. We hypothesise that this more comprehensive educational approach in the early treatment phase of breast cancer will lead to more beneficial effects for cancer pain management. Therefore, the aim of the present study is to investigate the effectiveness of this PNE intervention, in addition to best evidence physical therapy modalities for treatment and prevention of pain, physical, emotional and work-related functioning after breast cancer surgery, compared with a traditional biomedical educational intervention.MethodsA double-blinded randomised controlled trial has been started in November 2017 at the University Hospitals of Leuven. Immediately after breast cancer surgery, all participants (n=184) receive a 12-week intensive standard physical therapy programme. They receive three additional refresher sessions at 6, 8 and 12 months postsurgery. In addition, participants receive three educational sessions during the first-month postsurgery and three ‘booster sessions’ at 6, 8 and 12 months postsurgery. In the intervention group, the content of the education sessions is based on the modern PNE approach. Whereas in the control group, the education is based on the traditional biomedical approach. The primary outcome parameter is pain-related disability 1 year after surgery. Secondary outcomes related to other dimensions of pain, physical, emotional and work-related functioning at 1-week, 4, 6, 8, 12 and 18 months postsurgery.Ethics and disseminationThe study will be conducted in accordance with the Declaration of Helsinki. This protocol has been approved by the ethical committee of the University Hospitals of Leuven. Results will be disseminated via peer-reviewed scientific journals and presentations at congresses.Trial registration numberNCT03351075.