bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY OF CEREBROTROPIC DOSE-DEPENDENT EFFECT OF PYRIMIDINE DERIVATIVE UNDER PIR-9 CODE AGAINST THE BACKGROUND OF EXPERIMENTAL CEREBRAL ISCHEMIA IN RATS
Authors: Voronkov A. V. , Shabanova N. B. , Voronkova M. P. , Lysenko T. A. 
Published: January 2019

Nowadays, the incidence of cerebrovascular disease is steadily increasing. Disorders of cerebral circulation contribute to the increase in the degree of mortality, disability, and incapacitation of the population. An extensive arsenal of drugs with cerebroprotective effects does not satisfy clinical specialists. In this connection, there is an obvious need for new compounds exhibiting cerebroprotropic properties, as well as those able of improving the prognosis of the course of ischemic genesis pathologies.The aimof the article is to study the dose-dependent cerebrotropic effect of a pyrimidine derivative under PIR-9 code against the background of experimental cerebral ischemia in rats.Materials and methods. The experiment was conducted on 140 male Wistar rats (m=170–190 g) divided into 7 equal groups. Pyrimidine derivative PIR – 9 (25, 50 and 100 mg/kg), Vinpocetine (3.2 mg/kg) and Cinnarizine (5.6 mg/kg) suspension of purified water and Tween-80 were used as the studied substances. Experimental cerebral ischemia was reproduced by irreversible occlusion of common carotid arteries (chloral hydrate anesthesia – 350 mg/kg). Experimental substances, reference preparations and purified water were administered prophylactically within 10 days before surgery. One day later the survival, neurological deficiency, behavioral activity, changes in cognitive-mnestic functions, as well as some indicators of brain energy exchange were evaluated.Results.In an experimental study of the cerebrotropic effect of the substance under PIR-9 code (pyrimidine-4-(1H)-one derivative) in various dosages against the background of irreversible occlusion of the common carotid arteries, a decrease in neurological, behavioral, mnestic and cognitive defects has been established. Hereby, the best effect was observed against the background of the administration of the compound PIR-9 at the dose of 50 mg kg. In addition, the prophylactic administration of the test substance PIR-9 (50 mg/kg) has shown the improvement of the energy metabolism in the postischemic period.Conclusion. In the course of the study it was established that the substance under the laboratory code PIR-9 exhibited the most pronounced cerebroprotective effect at the dose of 50 mg/ kg, which was not inferior in its strength to the reference drug Cinnarizine and exceeding Vinpocetine.
ANALYSIS OF ADVERSE DRUG REACTION REPORT FORMS ON THE MEDICINES, USED FOR AIDS TREATMENT (REGISTERED IN THE REPUBLIC OF CRIMEA IN THE PERIOD FROM 2011 TO 2016)
Authors: Matveev A. V. , Krasheninnikov A. Е. , Egorova E. A. , Konyaeva E. I. 
Published: January 2019

According to the data of the World Health Organization (WHO), human immunodeficiency virus (HIV) remains a major global public health problem.The mainmethod of treating HIV is using highly active antiretroviral therapy (HAART), which is the use of multiple medicines acting on different viral targets. The timely onset of HAART can suppress the replication of the virus in the human body and helps to strengthen its immune system and restore its ability to fight infections. At the same time, the choice of medicines to improve the quality of life and patients’ compliance during antiretroviral therapy should be based on their effectiveness and safety. The aim of this research was to analyze and study the adverse reactions that occur in patients with HIV living in the territory of the Republic of Crimea, when using HAART.Materials and methods.The objects of research were 274 report cards about the adverse reactions, registered in the regional base (registry) of spontaneous messages called ARCADe (Adverse Reactions in Crimea, Autonomic Database) for the period from 2011 to 2016.Results.The results of the study showed that the most often adverse reactions were observed when using medicines of the group of Nucleoside Reverse Transcriptase Inhibitors (NRTI). This is explained by the inclusion of NRTI medicines as the main medicine in the method of HAART. Efavirenz (EFV) and Nevirapine (NVP) were absolute leaders among these groups of antiretroviral medicines. Among the combined antiviral medicines active against HIV, the most frequently adverse reactions were associated with the use of a combination of Lamivudine (3TC) and Zidovudine (ZDV). The main clinical manifestations of adverse reactions in the use of combination medicines for treating HIV were a decrease in the level of hemoglobin and the development of anemia. At the same time, in 85% of cases, the patients needed medication in order to correct the resulting adverse drug reaction (ADR). The combination of antiretroviral therapy has often been associated with the development of serious ADR. In case of monotherapy, the main clinical manifestations of adverse reactions were disorders of the central nervous system (dizziness, hallucinations, sleep disorders) and allergic reactions of varying severity (including 1 case of angioedema to “Eferven” (Efavirenz (EFV)),600 mg). Hereby, in almost half of the cases, the usage of antiretroviral medicines of the NRTI group and protease inhibitors caused the development of serious side effects. This confirms the necessity to study and analyze adverse reactions in order to increase the safety of patients’ pharmacotherapy and improve their quality of life.Conclusion.The study of adverse reactions to the medicines used for treatment of HIV is of a paramount importance in improving the safety and compliance of HIV patients to lifelong pharmacotherapy.
Service Mechanism and Pricing Based on Fairness Preference of Customers in Queuing System
Authors: Xu Yong , Liu Jian , Ma Baomei , Zhang Shuai 
Published: January 2019

AbstractService providers often adopt the mechanism of customer classification due to the heterogeneity of customer waiting cost. However, the classification service may cause unfairness feeling of regular customers, then affect the revenue and social welfare. This paper provides the first exact analysis about the situation that service providers offer two classes of non-preemptive priority service when customer fairness perception is explicitly modeled. We model customer fairness perception as a negative utility on regular customers that’s proportional to the waiting time difference between the two queues. By analyzing a stylized M/M/1 queue in monopoly service system, we can derive important results some of which reaffirm existed research results. First, from the perspective of revenue maximization, service providers should also adopt the mechanism of customer classification and set up the two kinds of customers where they can see each other. Next, considering customer utility maximization, service providers should cancel the mechanism of customer classification, and keep one queue (regular customers) only. Then, from the perspective of social welfare maximization, service providers should also adopt the mechanism of customer classification but set up the two kinds of customers where they cannot feel each other. Finally, this paper concludes the optimal pricing based on customer classification in the above three different perspectives. This research shows important reference value and practical significance for service providers who adopt the mechanism of classification service.
Do Macroeconomic Determinants of Non-Performing Loans Vary with the Income Levels of Countries?
Authors: Koju Laxmi , Abbas Ghulam , Wang Shouyang 
Published: January 2019

Abstract
This paper explores the macroeconomic determinants of non-performing loans (NPL) in 19 Asian countries (low to high income economies) using the Generalized Method of Moments estimation approach based on the economic data for the period between 1998 and 2015. The categorization of the economies is based on the average gross national income per capita as set by the World Bank. Specifically, the paper aims to evaluate if the determinants of NPL vary with the income levels of the countries. The results indicate that the NPL is strongly influenced by the inflation rate. The effect is, however, negative in the high-income and the middle-income countries and positive in the low-income countries. The GDP per capita has a dynamic negative relationship with the NPL in the high-income and the low-income countries. The remittance has a significant positive association in the high-income and a significant negative association in the low-income countries. Similarly, the unemployment rate has a positive effect on NPL in the middle-income and the low-income countries. With the rise in the official exchange rate, the NPL level increases in the low-income countries. The overall estimation results suggest that the NPL in Asian banking system depend on some key macroeconomic variables, such as unemployment rate, inflation rate, official exchange rate, remittance received and gross domestic product per capita, and these associations vary with the income level of the countries. Therefore, economic level of a country should be carefully considered while formulating credit policy to minimize credit risks in the banking system.
Priority Setting in Health Care with Disease and Treatment Risks
Authors: Tao Yuqing , Cheng Wen , Zou Sijie 
Published: January 2019

Abstract
This paper deals with the issue of priority setting in health care under uncertainties about the severity of the illness and the effectiveness of medical treatment. We examine the effect of a disease uncertainty (a treatment uncertainty) on the allocation of health care resources in the presence of a treatment risk (a disease risk) and identify preference conditions under which the social planner allocates more resources to higher risk population. We allow for the simultaneous presence of two risks and investigate the joint effect of two-source uncertainties on health care allocation when the two risks are either small or positively quadrant dependent. The effect of inequality aversion on health care allocation is also analyzed by introducing an equity weighting function. Our work extends the previous model of health care priority to two-risk framework and provides new insights into the problem of health care decision making under uncertainty.
Editorial responsibilities
Authors: .. .. 
Published: January 2019

Editorial responsibilities

Editors
Jessica Lange, Editor-in-Chief, McGill University
Jennifer Easter, Section Editor (Innovations in Practice), Centennial College
Linda Ecclestone, Section Editor (Book Reviews), Lasalle Secondary School
Éthel Gamache, Section Editor (French Language), Concordia University
Corinne Gilroy, Layout Editor, Mount Saint Vincent University
Tamara Noor, Section Editor (Features), Western University
Rainer Schira, Layout Editor, Brandon University
Ann Smith, Section Editor (Theory & Research), Acadia University

Copyeditors
Chris Landry, OCAD University
Allana Mayer, OurDigitalWorld
Emily Tyschenko, Guelph Public Library
Lindsay McNiff, Dalhousie University
Greg Nightingale, Western University
Dahlal Mohr-Elzeki, McGill University Health Centre Libraries
Andrea Quaiattini, McGill University

Proofreaders
Deborah Hemming, Acadia University
Mylène Pinard, McGill University
Tanya Ulmer, Internet Archive Canada (Alberta)

Social Media & Web Design
Graham Lavender, Web Design Coordinator, Michener Institute of Education at UHN
Natalie Colaiacovo, Digital & Social Media Coordinator, Centennial College

Translation
Patrick Labelle, Translator, University of Ottawa
Maternal Mortality at the Dori Regional Hospital in Northern Burkina Faso, 2014-2016
Authors: Zamané Hyacinthe , Sow Hyacinthe Euvrard , Kain Dantola Paul , Bicaba Brice Wilfried , Kiemtoré Sibraogo , Yameogo Issaka , Bonané-Thieba Blandine , Sawadogo Mamadou 
Published: January 2019

Background: Maternal mortality is of considerable magnitude. It is particularly relevant to developing countries, including those in Sub-Saharan Africa. The aim of this work was to study the cases of maternal deaths in the Dori Regional Hospital, Burkina Faso in the Sahel region, by analyzing the epidemiological aspects of these deaths in order to guide decision-making.
Methods: This was a descriptive cross-sectional study which spanned the period from January 1, 2014 to December 31, 2016. Cases of maternal death and live births that occurred in the hospital during this period were collected by documentary review.
Results: A total of 141 maternal deaths and 2,626 live births were recorded with a maternal mortality ratio of 5,369 for 100,000 live births. In 99 (72.20%) cases, death occurred in the postpartum. A home delivery had been reported in 33.70% of cases. Direct obstetric causes were found in 72.10% of cases. They were mainly represented by infections (32.40%) and hemorrhages (23%). Anemia was the indirect cause of death in 25 women (17.80%). The delay in health care access and the lack of blood products contributed to maternal deaths in 64.50% and 26.20% of cases.
Conclusion and Global Health Implications: An intensification of awareness-raising messages about the importance of the rapid use of health care is necessary. Also, systematic audits of maternal deaths in the care environment and in the community would make it possible to clarify the determinants of maternal mortality in the Sahel region and to provide adequate solutions.
Key words: Maternal Death • Maternal Mortality • Women’s Health • Burkin Faso • Dori Hospital • Sahel Region

Copyright © 2018 Zamané et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The Role of CXCR3 in Neurological Diseases
Authors: Zhou Ya-Qun , Liu Dai-Qiang , Chen Shu-Ping , Sun Jia , Zhou Xue-Rong , Xing Cui , Ye Da-Wei , Tian Yu-Ke 
Published: January 2019

Background:Neurological diseases have become an obvious challenge due to insufficient therapeutic intervention. Therefore, novel drugs for various neurological disorders are in desperate need. Recently, compelling evidence has demonstrated that chemokine receptor CXCR3, which is a G protein-coupled receptor in the CXC chemokine receptor family, may play a pivotal role in the development of neurological diseases. The aim of this review is to provide evidence for the potential of CXCR3 as a therapeutic target for neurological diseases. </P><P> Methods: English journal articles that focused on the invovlement of CXCR3 in neurological diseases were searched via PubMed up to May 2017. Moreover, reference lists from identified articles were included for overviews.Results:The expression level of CXCR3 in T cells was significantly elevated in several neurological diseases, including multiple sclerosis (MS), glioma, Alzheimer’s disease (AD), chronic pain, human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and bipolar disorder. CXCR3 antagonists showed therapeutic effects in these neurological diseases.Conclusion:These studies provided hard evidence that CXCR3 plays a vital role in the pathogenesis of MS, glioma, AD, chronic pain, HAM/TSP and bipolar disorder. CXCR3 is a crucial molecule in neuroinflammatory and neurodegenerative diseases. It regulates the activation of infiltrating cells and resident immune cells. However, the exact functions of CXCR3 in neurological diseases are inconclusive. Thus, it is important to understand the topic of chemokines and the scope of their activity in neurological diseases.
Synthesis and Evaluation of the in vitro Antimicrobial Activity of Triazoles, Morpholines and Thiosemicarbazones
Authors: Santos Felipe R.S. , Andrade Jéssica T. , Sousa Carla D.F. , Fernandes Joice S. , Carmo Lucas F. , Araújo Marcelo G.F. , Ferreira Jaqueline M.S. , Villar José A.F.P. 
Published: January 2019

Background:
Microbial infections is a global public health problem. The aim of this
work was to synthesize and evaluate the antimicrobial activity of novel triazoles, morpholines and
thiosemicarbazones.
</P><P>
Methods: Compounds were synthesized using 2,4-Dihydroxyacetophenone and 4-hydroxybenzaldehyde
as starting materials. The antimicrobial activity of these compounds against bacteria
and yeast was evaluated by the broth microdilution method.

Results:
The proposed route for synthesis gave high to moderate yields, moreover these compounds
were successfully characterized by 1H NMR, 13C NMR and LC-MS. Antimicrobial testing
indicated that the thiosemicarbazone and morphine derivatives had the best antimicrobial activity
against the microorganisms tested with minimum inhibitory concentrations (MIC) between 0.29
and 5.30 µM. Thiosemicarbazone derivative (12) was able to inhibit the growth of C. tropicalis,
with minimum fungicidal concentration (MFC) of 0.55 µM. In addition, this compound was active
against E. coli, S. aureus and S. epidermidis, with MIC values ranging from 0.29 to 1.11 µM.
Moreover, the morpholine derivative (15) had an MIC value of 0.83 µM against C. albicans and
E. coli.

Conclusion:
We have efficiently synthesized a series of eleven novel triazoles, thiosemicarbazones
and morpholine derivatives using 2,4-Dihydroxyacetophenone and 4-hydroxybenzaldehyde
as starting materials. Thiosemicarbazone derivative (12) showed promising antifungal and antibacterial
activity and these findings suggest that this compound can be used as scaffolds to design
new antimicrobial drugs.
The Use of Keyword and Imagery Mnemonic for Vocabularies Learning for AFL Students
Authors: Sari Risna Rianti 
Published: January 2019

اليوم ، يدرك العديد من الباحثين أن المفردات مهمة وهي جزء من عملية تعليم اللغة الثانية. ولكن الطلاب الذين يتعلمون اللغة العربية غالباً يشتكون عند التعامل مع المفردات الجديدة ، فبعضهم يجدون صعوبة في تذكر ما حفظوه. فلذلد عرضت الكاتبة طريقة تسمى "فن الإستذكار" (mnemonic) لمتعلمي اللغة العربية. هذه الطريقة يمكن أن تكون حلاً للمشاكل التي تواجهها ويمكن أن تحسن من تعليم المفردات العربية. تستكشف هذه المقالة عن نظرية mnemonic وكيف إجرائه في حفظ المفردات العربية. هناك أنواع عديدة من فن الإستذكار نفسها ، ولكن ذكرت الكاتبة نوعان منها الكلمات الرئيسية وتقنيات الرسم. هذان النوعان من فن الإستذكار لا يمكن إنكار أنهما فعالة في عملية تعلم اللغة العربية، يمكن أن تحسن القدرة على الاستدعاء مباشرة. سوف توضح هذه المقالة حول طريقة ذاكري وكيفية تطبيقه.
دراسة حالة عن ميول طلبة في تعلم اللغة العربية بالمدارس المتوسطة الإسلامية بمالانج وباتو
Authors: Murdiono Murdiono 
Published: January 2019

The research aims to discuss the motivation of students (Case Study) in Madrasah Tsanawiyah Negeri (MTs.N) 1 Malang, Madrasah Tsanawiyah Negeri (MTs.N) Batu, Madrasah Tsanawiyah (MTs.) Surya Buana Malang unfortunate to learning Arabic. The methodology used by the researchers in this study is a quantitative method. As for the results of the students' responses to three aspects, namely cognitive, effective and concentration aspects through filling in student motivation questionnaires, interviews, and observations in learning Arabic as a whole of MTs.N Batu 2.76%, that can be grouped into medium. Then aspects of the student's interest in learning Arabic are overall average in MTs.N 1 Malang 2.71% so that the poor can be grouped in category medium, and aspects of the student's interest in learning Arabic as a whole on average in MTs. Surya Buana are 2.67% so it can be grouped in group Medium. Based on the analysis of data that has been discussed that the interest of students in MTs.N 1 Malang, MTs.N Batu, MTs. Surya Buana are classified into group Medium.
Pengembangan Hand-Out Konsep Larutan Berintegrasi Nilai Religi Untuk Meningkatkan Minat Belajar Siswa Sma Pada Pondok Pesantren Terpadu
Authors: Sulastri Sulastri , Nazar Muhammad , Adiska Dessi Nur 
Published: January 2019

Telah dilakukan penelitian pengembangan hand-out materi larutan berintegrasi nilai religi untuk meningkatkan minat belajar siswa. Penelitian ini bertujuan untuk mengembangkan hand-out konsep larutan berintegrasi nilai religi, mengetahui tanggapan guru dan siswa terhadap hand-out, mengetahui kualitas hand-out berdasarkan penilaian para ahli. Metode penelitian yang digunakan yaitu penelitian dan pengembangan (RD) dengan model ADDIE. Uji coba dilakukan di SMA Muta’allimin Aceh Besar dengan melibatkan 15 orang siswa. Hasil penelitian menunjukkan bahwa minat siswa secara keseluruhan sebelum penggunaan hand-out rata-rata sebesar 60,48% setelah penggunaan hand-out meningkat menjadi 69,59%. Hasil minat siswa per indikator diperoleh bahwa rasa senang sebelum penggunaan hand-out sebesar 63,59 setelah penggunaan hand-out sebesar 71,79%. Indikator perhatian sebelum penggunaan hand-out sebesar 65,19% setelah penggunaan hand-out sebesar 75,56%. Indikator keterlibatan sebelum penggunaan hand-out sebesar 73,33% setelah penggunaan hand-out sebesar 78,10%. Indikator ketertarikan sebelum penggunaan hand-out sebesar 41,48% setelah penggunaan hand-out sebesar 54,07%. Nilai N-Gain yang diperoleh dari indikator rasa senang sebesar 22,52%, indikator perhatian sebesar 29,79%, indikator keterlibatan sebesar 17,89 dan indikator ketertarikan sebesar 21,51%. Indikator perhatian tergolong kategori sedang, sedangkan indikator rasa senang, keterlibatan dan ketertarikan tergolong kategori rendah. Dengan demikian dapat disimpulkan minat siswa meningkat setelah penggunaan hand-out berintegrasi nilai religi.
PEMETAAN KECEPATAN GELOMBANG GESER (Vs30) DI KECAMATAN KUTA ALAM KOTA BANDA ACEH MENGGUNAKAN METODE MASW
Authors: Jamaluddin Khaizal , Ulfa Rahmatul , Irwandi Irwandi , Chairullah Banta 
Published: January 2019

Abstract : The Aceh Province lies on the main fault line commonly known as Sumatran Faults. Therefore, in particular the Banda Aceh City frequent earthquakes as a result of the active geological structure of Sumatran fault in the Aceh region. Banda Aceh is a sedimentary basin in which to experience the amplification due to seismic waves. The behavior of the seismic waves propagating in the sediment layer is measured by the Vs30 parameter. The research was conducted on the strategic area of Banda Aceh City, Kuta Alam District, which is a densely populated subdistrict. Vs30 mapping based on soil hardness level according to UBC (Uniform Building Code), EC8 (Euro Code 8), and SNI 1726-2012. Seismic data acquisition was acquired at ten locations in the research area considered to have covered one area of Kuta Alam sub-district, Banda Aceh City. The result obtained is map of the distribution of soil condition based on Vs30 parameter. Based on the map obtained by the District of Kuta AlamKeywords : Earthquake, Faults, Sedimentation, Amplification.Abstrak: Provinsi Aceh terletak pada jalur patahan utama Sumatera yang umum dikenal Sumatera faults. Oleh karena itu, khususnya Kota Banda Aceh sering terjadi gempa bumi sebagai akibat dari struktur geologi aktif patahan sumatera di wilayah Aceh tersebut. Kota Banda Aceh merupakan cekungan di mana sedimen mengalami amplifikasi gelombang gempa. Perilaku gelombang gempa yang merambat pada lapisan sedimen diukur berdasarkan parameter Vs30. Penelitian dilakukan pada kawasan strategis Kota Banda Aceh yaitu Kecamatan Kuta Alam yang merupakan Kecamatan padat penduduk. Pemetaan Vs30 berdasarkan acuan dalam perencanaan bangunan konstruksi tahan gempa berdasarkan tingkat kekerasan tanah menurut UBC (Uniform Building Code), EC8 (Euro Code 8), dan SNI 1726-2012. Pengambilan data seismik diakuisisi pada sepuluh lokasi di wilayah penelitian yang dianggap telah mencakup satu wilayah Kecamatan Kuta alam, Kota Banda Aceh. Hasil yang didapat adalah peta sebaran kondisi tanah berdasarkan parameter Vs30. Berdasarkan peta diperoleh wilayah Kecamatan Kuta Alam Kota Banda Aceh hanya sebagian kecil lapisan tanah sedang.Kata kunci : Gempa Bumi, Patahan, Sedimen, Amplifikasi.