bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort
Authors: Shah Arya , Hoffman E Matthew , Mauermann Michelle L , Loprinzi Charles L , Windebank Anthony J , Klein Christopher J , Staff Nathan P 
Published: February 2018

ObjectiveTo assess disease burden of chemotherapy-induced peripheral neuropathy (CIPN), which is a common dose-limiting side effect of neurotoxic chemotherapy. Late effects of CIPN may increase with improved cancer survival.MethodsOlmsted County, Minnesota residents receiving neurotoxic chemotherapy were identified and CIPN was ascertained via text searches of polyneuropathy symptoms in the medical record. Clinical records were queried to collect data on baseline characteristics, risk factors, signs and symptoms of CIPN, medications, impairments and International Classification of Diseases, Ninth Revision (ICD-9) diagnostic codes for all subjects.ResultsA total of 509 individuals with incident exposure to an inclusive list of neurotoxic chemotherapy agents between 2006 and 2008 were identified. 268 (52.7%) of these individuals were determined to have CIPN. The median time from incident exposure to first documented symptoms was 71 days. Patients with CIPN received a neuropathy ICD-9 diagnosis in only 37 instances (13.8%). Pain symptoms and use of pain medications were observed more often in patients with CIPN. Five-year survival was greater in those with CIPN (55.2%) versus those without (36.1%). Those with CIPN surviving greater than 5 years (n=145) continued to have substantial impairments and were more likely to be prescribed opioids than those without CIPN (OR 2.0, 1.06–3.69).ConclusionsResults from our population-based study are consistent with previous reports of high incidence of CIPN in the first 2 years following incident exposure to neurotoxic chemotherapeutic agents, and its association with significant pain symptomatology and accompanied long-term opioid use. Increased survival following exposure to neurotoxic chemotherapy and its long-term disease burden necessitates further study among survivors.
Co-occurrence of depressive symptoms and executive dysfunction after stroke: associations with brain pathology and prognosis
Authors: Douven Elles , Aalten Pauline , Staals Julie , Schievink Syenna H J , van Oostenbrugge Robert J , Verhey Frans R J , Köhler Sebastian 
Published: February 2018

ObjectiveTo examine, first, whether the co-occurrence of executive dysfunction (ED) and poststroke depression (PSD) shows different associations with neuroimaging markers and the course of depression and executive function, and second, whether it is associated with a different course on other cognitive domains and quality of life.MethodsThe present study included 245 stroke patients (35.9% female, mean age 67.5 years (SD=11.9). All patients completed neuropsychological and neuropsychiatric assessment 3 months poststroke, which were repeated at 6-month and 12-month follow-up. A subset (n=186) received 3-Tesla brain MRI at baseline to evaluate lesion-related imaging markers, white matter hyperintensity volume, global brain atrophy and total cerebral small vessel disease burden.ResultsPatients with ‘depression–executive dysfunction syndrome’ (DES) showed higher white matter hyperintensity volumes compared with all other groups and more frequently showed left-sided lesions compared with ED only and PSD only. They also had more frequently old infarcts and higher total cerebral small vessel disease burden compared with PSD only and patients with neither ED nor PSD, and more global brain atrophy compared with PSD only. Longitudinal analyses showed that patients with DES had a more chronic course of depressive symptoms relative to PSD only, and a stable pattern of worse cognitive performance similar to patients with ED only.ConclusionsThe co-occurrence of ED and PSD is associated with a worse prognosis of depression, persistent cognitive impairment and a higher amount of vascular and degenerative brain pathology. Future studies are needed to examine whether these patients represent a more severe subtype within the PSD spectrum.Clinical trial registrationNCT02585349;Results.
Social networks as drivers of syphilis and HIV infection among young men who have sex with men
Authors: Fujimoto Kayo , Flash Charlene A , Kuhns Lisa M , Kim Ju-Yeong , Schneider John A 
Published: February 2018

ObjectivesSyphilis and HIV epidemics overlap, yet little is known about combined network and behavioural factors that drive syphilis-HIV coinfection. Our study objective was to assess network contexts and sexual behaviours associated with syphilis-HIV co-infection and monoinfection among a particularly vulnerable subgroup: young Black men who have sex with men (YBMSM). To achieve this objective, we examined factors associated with coinfection by each subgroup as classified by syphilis-HIV infection status: (A) HIV monoinfected, (B) syphilis monoinfected and (C) neither syphilis infected nor HIV infected. In addition, we further identified the factors that are associated with HIV infection or syphilis monoinfection.MethodsData were collected from a sample of 365 YBMSM, aged 16–29 years, recruited through respondent-driven sampling between 2014 and 2016, in two cities with large HIV epidemics: Houston, TX, and Chicago, IL. We conducted a series of multinomial logistic regression models to predict coinfection, HIV monoinfection and syphilis monoinfection as a function of network and sexual behavioural factors.ResultsCoinfection was associated with having network members who are coinfected or HIV infected within one’s social network. Syphilis monoinfection was associated with a higher number of social venues attended, and HIV monoinfection was associated with having more condomless top partners.ConclusionPublic health interventions that address the diagnosis and treatment of syphilis infection and ensure that those with syphilis are being tested for HIV may be promising in limiting the synergy of syphilis-HIV infections in onward transmission. Advancing HIV and syphilis prevention efforts in high-prevalence networks may allow prioritisation of limited resources.
Definability of Cai-Fürer-Immerman Problems in Choiceless Polynomial Time
Authors: Pakusa Wied , Schalthöfer Svenja , Selman Erkal 
Published: February 2018

Choiceless Polynomial Time (CPT) is one of the most promising candidates in the search for a logic capturing P
time
. The question whether there is a logic that expresses exactly the polynomial-time computable properties of finite structures, which has been open for more than 30 years, is one of the most important and challenging problems in finite model theory.

The strength of Choiceless Polynomial Time is its ability to perform isomorphism-invariant
computations
over structures, using hereditarily finite sets as data structures. But, because of isomorphism-invariance, it is choiceless in the sense that it cannot select an arbitrary element of a set—an operation that is crucial for many classical algorithms. CPT can define many interesting P
time
queries, including (a certain version of) the Cai-Fürer-Immerman (CFI) query. The CFI-query is particularly interesting, because it separates fixed-point logic with counting from P
time
and has since remained the main benchmark for the expressibility of logics within P
time
.

The CFI-construction associates with each connected graph a set of CFI-graphs that can be partitioned into exactly two isomorphism classes called odd and even CFI-graphs. The problem is to decide, given a CFI-graph, whether it is odd or even. For the case where the CFI-graphs arise from ordered graphs, Dawar, Richerby, and Rossman proved that the CFI-query is CPT-definable. However, definability of the CFI-query over general graphs remains open.
Our first contribution generalises the result by Dawar, Richerby, and Rossman to the variant of the CFI-query derived from graphs with colour classes of logarithmic size, instead of colour class size one. Second, we consider the CFI-query over graph classes where the maximal degree is linear in the size of the graphs. For the latter, we establish CPT-definability using only sets of small, constant rank, which is known to be impossible for the general case.
In our CFI-recognising procedures we strongly make use of the ability of CPT to create sets, rather than tuples only, and we further prove that, if CPT worked over tuples instead, then no such procedure would be definable. We introduce a notion of “sequencelike objects” based on the structure of the graphs’ symmetry groups, and we show that no CPT-program that only uses sequencelike objects can decide the CFI-query over complete graphs, which have linear maximal degree. From a broader perspective, this generalises a result by Blass, Gurevich, and van den Bussche about the power of isomorphism-invariant machine models (for polynomial time) to a setting with counting.
Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation
Authors: Takagi Satoshi , Tsukamoto Shokichi , Park Jihye , Johnson Kelly E. , Kawano Yawara , Moschetta Michele , Liu Chia-Jen , Mishima Yuji , Kokubun Katsutoshi , Manier Salomon , Salem Karma Z. , Huynh Daisy , Sacco Antonio , Forward Jodi , Roccaro Aldo M. , Battinelli Elisabeth M. , Ghobrial Irene M. 
Published: February 2018

Abstract
Purpose: Tumor cell–platelet interactions contribute to tumor progression and metastasis in solid tumors. However, the role of platelets in hematological malignancies is not clear. We investigated the association of platelet activation status with clinical stages in multiple myeloma (MM) patients and explored the role of platelets in MM progression.
Experimental Design: Platelets were obtained from healthy donors and MM patients. We examined platelet activation status in MM patients by flow cytometry and transmission electron microscopy. We also observed the enriched pathways that are involved with platelet activation in RNA sequencing of platelets. MM cell lines were used to assess the effect of platelets on MM cell proliferation in vitro and their engraftment in vivo. RNA sequencing of MM cell lines was performed to explore molecular mechanisms underlying MM cell–platelet interaction and a CRISPR/Cas9 knockout approach was used for validation.
Results: Platelets from MM patients were highly activated with disease progression. RNA sequencing of platelets revealed that genes involved in platelets were enriched in patients with smoldering MM (SMM) or MM. Platelets promoted MM cell proliferation in vitro and contributed to tumor engraftment in bone marrow in vivo. RNA sequencing revealed that IL-1β was upregulated in MM cell lines co-cultured with platelets, whereas IL-1β knockout in MM cell lines abrogated the effects of platelets on MM cell proliferation and engraftment in vivo.
Conclusions: Platelets from MM patients were highly activated with disease progression. IL-1β is critical to platelet-mediated MM progression and might be a potential target for MM treatment. Clin Cancer Res; 24(10); 2430–9. ©2018 AACR.
Pan-Cancer Molecular Classes Transcending Tumor Lineage Across 32 Cancer Types, Multiple Data Platforms, and over 10,000 Cases
Authors: Chen Fengju , Zhang Yiqun , Gibbons Don L. , Deneen Benjamin , Kwiatkowski David J. , Ittmann Michael , Creighton Chad J. 
Published: February 2018

Abstract
Purpose: The Cancer Genome Atlas data resources represent an opportunity to explore commonalities across cancer types involving multiple molecular levels, but tumor lineage and histology can represent a barrier in moving beyond differences related to cancer type.
Experimental Design: On the basis of gene expression data, we classified 10,224 cancers, representing 32 major types, into 10 molecular-based “classes.” Molecular patterns representing tissue or histologic dominant effects were first removed computationally, with the resulting classes representing emergent themes across tumor lineages.
Results: Key differences involving mRNAs, miRNAs, proteins, and DNA methylation underscored the pan-cancer classes. One class expressing neuroendocrine and cancer-testis antigen markers represented ∼4% of cancers surveyed. Basal-like breast cancers segregated into an exclusive class, distinct from all other cancers. Immune checkpoint pathway markers and molecular signatures of immune infiltrates were most strongly manifested within a class representing ∼13% of cancers. Pathway-level differences involving hypoxia, NRF2-ARE, Wnt, and Notch were manifested in two additional classes enriched for mesenchymal markers and miR200 silencing.
Conclusions: All pan-cancer molecular classes uncovered here, with the important exception of the basal-like breast cancer class, involve a wide range of cancer types and would facilitate understanding the molecular underpinnings of cancers beyond tissue-oriented domains. Numerous biological processes associated with cancer in the laboratory setting were found here to be coordinately manifested across large subsets of human cancers. The number of cancers manifesting features of neuroendocrine tumors may be much higher than previously thought, which disease is known to occur in many different tissues. Clin Cancer Res; 24(9); 2182–93. ©2018 AACR.
Targeting HSF1: A Prime Integrator of Proteotoxic Stress Response in Myeloma
Authors: Parekh Samir 
Published: February 2018

AbstractThe HSF1 transcription factor is an integrator of the cellular stress response, and its expression has demonstrated poor prognosis in multiple myeloma. The novel anti-HSF1 small-molecule inhibitors CCT251236 and KRIB11 demonstrate in vitro and in vivo antimyeloma activity, representing a novel approach for targeting the heat shock response in myeloma. Clin Cancer Res; 24(10); 2237–8. ©2018 AACR.See related article by Fok et al., p. 2395
Reduced Intravoxel Incoherent Motion Microvascular Perfusion Predicts Delayed Cerebral Ischemia and Vasospasm After Aneurysm Rupture
Authors: Heit Jeremy J. , Wintermark Max , Martin Blake W. , Zhu Guangming , Marks Michael P. , Zaharchuk Greg , Dodd Robert L. , Do Huy M. , Steinberg Gary K. , Lansberg Maarten G. , Albers Gregory W. , Federau Christian 
Published: February 2018

Background and Purpose—
Proximal artery vasospasm and delayed cerebral ischemia (DCI) after cerebral aneurysm rupture result in reduced cerebral perfusion and microperfusion and significant morbidity and mortality. Intravoxel incoherent motion (IVIM) magnetic resonance imaging extracts microvascular perfusion information from a multi-b value diffusion-weighted sequence. We determined whether decreased IVIM perfusion may identify patients with proximal artery vasospasm and DCI.

Methods—
We performed a pilot retrospective cohort study of patients with ruptured cerebral aneurysms. Consecutive patients who underwent a brain magnetic resonance imaging with IVIM after ruptured aneurysm treatment were included. Patient demographic, treatment, imaging, and outcome data were determined by electronic medical record review. Primary outcome was DCI development with proximal artery vasospasm that required endovascular treatment. Secondary outcomes included mortality and clinical outcomes at 6 months.

Results—

Sixteen patients (11 females, 69%;
P
=0.9) were included. There were no differences in age, neurological status, or comorbidities between patients who subsequently underwent endovascular treatment of DCI (10 patients; DCI+ group) and those who did not (6 patients; DCI− group). Compared with DCI− patients, DCI+ patients had decreased IVIM perfusion fraction
f
(0.09±0.03 versus 0.13±0.01;
P
=0.03), reduced diffusion coefficient
D
(0.82±0.05 versus 0.92±0.07×10
−3
mm
2
/s;
P
=0.003), and reduced blood flow–related parameter
fD
* (1.18±0.40 versus 1.83±0.40×10
−3
mm
2
/s;
P
=0.009). IVIM pseudodiffusion coefficient
D
* did not differ between DCI− (0.011±0.002) and DCI+ (0.013±0.005 mm
2
/s;
P
=0.4) patients. No differences in mortality or clinical outcome were identified.

Conclusions—

Decreased IVIM perfusion fraction
f
and blood flow–related parameter
fD
* correlate with DCI and proximal artery vasospasm development after cerebral aneurysm rupture.
Thaumastic Acoustics
Authors: Passmore Oliver 
Published: February 2018

AbstractThis article considers Pindar’s use of the expression θαῦµα … ἀκοῦσαι, ‘a wonder to hear’, inPythian1 to describe the monster Typhoeus. I argue that the expression needs to be read against Hesiod’s use of a similar locution, θαύµατ’ ἀκοῦσαι, to describe Typhoeus in theTheogony. There, Hesiod adapts the common epic formula θαῦµα ἰδέσθαι, producing a unique phrase to indicate Typhoeus’ chaotic blending of sights and sounds, and at the same time his disruption of the rules of poetic communication. Typhoeus’ disharmonious poetics there stands in contrast to the orderly image of the choral Muses in the proem. I argue in turn that Pindar subtly reworks the Hesiodic formula to reflect Typhoeus’ defeat by Zeus, and thereby subsumes the monster’s ‘acoustics’ within the θαῦµα of the choral performance of the ode itself.
Continental U.S. Hurricane Landfall Frequency and Associated Damage: Observations and Future Risks
Authors: Klotzbach Philip J. , Bowen Steven G. , Pielke Roger , Bell Michael 
Published: February 2018

AbstractContinental United States (CONUS) hurricane-related inflation-adjusted damage has increased significantly since 1900. However, since 1900 neither observed CONUS landfalling hurricane frequency nor intensity shows significant trends, including the devastating 2017 season.Two large-scale climate modes that have been noted in prior research to significantly impact CONUS landfalling hurricane activity are El Niño–Southern Oscillation on interannual time scales and the Atlantic multidecadal oscillation on multidecadal time scales. La Niña seasons tend to be characterized by more CONUS hurricane landfalls than El Niño seasons, and positive Atlantic multidecadal oscillation phases tend to have more CONUS hurricane landfalls than negative phases.Growth in coastal population and regional wealth are the overwhelming drivers of observed increases in hurricane-related damage. As the population and wealth of the United States has increased in coastal locations, it has invariably led to the growth in exposure and vulnerability of coastal property along the U.S. Gulf and East Coasts. Unfortunately, the risks associated with more people and vulnerable exposure came to fruition in Texas and Florida during the 2017 season following the landfalls of Hurricanes Harvey and Irma. Total economic damage from those two storms exceeded $125 billion. Growth in coastal population and exposure is likely to continue in the future, and when hurricane landfalls do occur, this will likely lead to greater damage costs than previously seen. Such a statement is made recognizing that the vast scope of damage from hurricanes often highlights the effectiveness (or lack thereof) of building codes, flood maps, infrastructure, and insurance in at-risk communities.
Evaluation of Global Precipitation Measurement Rainfall Estimates against Three Dense Gauge Networks
Authors: Tan Jackson , Petersen Walter A. , Kirchengast Gottfried , Goodrich David C. , Wolff David B. 
Published: February 2018

Abstract
Precipitation profiles from the Global Precipitation Measurement (GPM) Core Observatory Dual-Frequency Precipitation Radar (DPR; Ku and Ka bands) form part of the a priori database used in the Goddard profiling algorithm (GPROF) for retrievals of precipitation from passive microwave sensors, which are in turn used as high-quality precipitation estimates in gridded products. As GPROF performs precipitation retrievals as a function of surface classes, error characteristics may be dependent on surface types. In this study, the authors evaluate the rainfall estimates from DPR Ku as well as GPROF estimates from passive microwave sensors in the GPM constellation. The evaluation is conducted at the level of individual satellite pixels (5–15 km) against three dense networks of rain gauges, located over contrasting land surface types and rainfall regimes, with multiple gauges per satellite pixel and precise accumulation about overpass time to ensure a representative comparison. As expected, it was found that the active retrievals from DPR Ku generally performed better than the passive retrievals from GPROF. However, both retrievals struggle under coastal and semiarid environments. In particular, virga appears to be a serious challenge for both DPR Ku and GPROF. The authors detected the existence of lag due to the time it takes for satellite-observed precipitation to reach the ground, but the precise delay is difficult to quantify. It was also shown that subpixel variability is a contributor to the errors in GPROF. These results can pinpoint deficiencies in precipitation algorithms that may propagate into widely used gridded products.
Impacts of Federally Funded State Obesity Programs on Adult Obesity Prevalence in the United States, 1998-2010
Authors: Koh Keumseok , Grady Sue C. , Vojnovic Igor , Darden Joe T. 
Published: February 2018

Objectives: From 2000 to 2010, the Division of Nutrition, Physical Activity, and Obesity (DNPAO) at the Centers for Disease Control and Prevention (CDC) funded 37 state health departments to address the obesity epidemic in their states through various interventions. The objective of this study was to investigate the overall impacts of CDC-DNPAO statewide intervention programs on adult obesity prevalence in the United States. Methods: We used a set of an individual-level, interrupted time-series regression and a quasi-experimental analysis to evaluate the overall effect of CDC-DNPAO intervention programs before (1998-1999) and after (2010) their implementation by using data from CDC’s Behavioral Risk Factor Surveillance System. Results: States that implemented the CDC-DNPAO program had a 2.4% to 3.8% reduction in the odds of obesity during 2000-2010 compared with states without the program. The effect of the CDC-DNPAO program varied by length of program implementation. A quasi-experimental analysis found that states with longer program implementation did not necessarily have lower odds of obesity than states with shorter program implementation. Conclusions: Statewide obesity interventions can contribute to reduced odds of obesity in the United States. Future research should evaluate the CDC-DNPAO programs in relation to their goals, objectives, and other environmental obesity risk factors to inform future interventions.