bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Biological Evaluation of Polyfluoroalkylated Antipyrines and their Isomeric O-Methylpyrazoles
Authors: Agafonova Natalya , Shchegolkov Evgeny , Burgart Yanina , Saloutin Victor , Trefilova Alexandra , Triandafilova Galina , Solodnikov Sergey , Maslova Vera , Krasnykh Olga , Borisevich Sophia , Khursan Sergey 
Published: November 2018

Background:
Formally belonging to the non-steroidal anti-inflammatory drug class
pyrazolones have long been used in medical practices.

Objective:
Our goal is to synthesize N-methylated 1-aryl-3-polyfluoroalkylpyrazolones as fluorinated
analogs of antipyrine, their isomeric O-methylated derivatives resembling celecoxib structure
and evaluate biological activities of obtained compounds.

Methods:
In vitro (permeability) and in vivo (anti-inflammatory and analgesic activities, acute toxicity,
hyperalgesia, antipyretic activity, “open field” test) experiments. To suggest the mechanism
of biological activity, molecular docking of the synthesized compounds was carried out into the
tyrosine site of COX-1/2.

Conclusion:
The trifluoromethyl antipyrine represents a valuable starting point in design of the
lead series for discovery new antipyretic analgesics with anti-inflammatory properties.
Evaluation of Preclinical Aphrodisiac Activity of Flueggea leucopyrus Willd. Leaves
Authors: Vasantrao Usnale S. , Biyani Kailash R. 
Published: November 2018

Background:
Flueggea leucopyrus Willd. leaf has been used since ancient time for its sex
enhancing activity by traditional physicians. So, the work was chosen to authenticate the knowledge of
pharmaceutical significance of the plant.

Methods:
The dried leaves of Flueggea leucopyrus were extracted by cold maceration method using
water. Aqueous extract of Flueggea leucopyrus leaf was screened for phytochemicals and in vivo aphrodisiac
activity using mating behavior, potency and morphological tests.

Results:
Qualitative phytochemical analysis of leaves of Flueggea leucopyrus showed the presence of
alkaloids, terpenoids, unsaturated sterols, glycosides, saponins, phenolics, flavonoids, tannins, carbohydrates
and protein. Results revealed that all the treated groups on the 15th, 30th and 45th day of treatment
showed significant increase in Intromission Frequency, Mounting Frequency and Ejaculatory Latency
significant decrease in Intromission Latency, Mounting Latency, Inter Intromission Interval and
Post Ejaculatory Interval. In Test for Potency significant increase in Erections, Long Flips and Quick
Flips were observed. Morphological study showed significant increase in reproductive organs weight
and Sperm Count in all the experimental animals.

Conclusion:
The prolonged treatments for all the treated groups were highly effective to increase the
sexual libidity, as compared to the solvent control. This indicates that aphrodisiac activity has been
shown by water extract but it is less than the standard used for study.
A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases
Authors: Zhao Jia , Zhu Mengxia , Kumar Mukesh , Ngo Fung Yin , Li Yinghui , Lao Lixing , Rong Jianhui 
Published: November 2018

Background & Objective: Alzheimer’s disease (AD) and Parkinson’s disease (PD) affect an
increasing number of the elderly population worldwide. The existing treatments mainly improve the
core symptoms of AD and PD in a temporary manner and cause alarming side effects. Naturally occurring
flavonoids are well-documented for neuroprotective and neurorestorative effects against various
neurodegenerative diseases. Thus, we analyzed the pharmacokinetics of eight potent natural products
flavonoids for the druggability and discussed the neuroprotective and neurorestorative effects and the
underlying mechanisms.

Conclusion:
This review provides valuable clues for the development of novel therapeutics against
neurodegenerative diseases.
Different Food Odors Control Brain Connectivity in Impulsive Children
Authors: de Celis-Alonso Benito , Hidalgo-Tobón Silvia S. , Barragán-Pérez Eduardo , Castro-Sierra Eduardo , Dies-Suárez Pilar , Garcia Julio , Moreno-Barbosa Eduardo , Arias-Carrión Oscar 
Published: November 2018

Background:Impulsivity is a complex multi-dimensional combination of behaviors which include: ineffective impulse control, premature decision-making and inability to delay gratification.Objective:The aim of this work was to explore how food odor perception and its emotional value is affected in impulsive children.Methods:Here we compared two cohorts of impulsive and control children with ages between 10 and 16 years. Both groups underwent a functional magnetic resonance imaging experiment, in which foodrelated odor-cues were presented to all of them.Results:Differences in regions of blood oxygen level dependent activation, as well as connectivity, were calculated. Activations were significant for all odors in the impulsive group in the temporal lobe, cerebellum, supplementary motor area, frontal cortex, medial cingulate cortex, insula, precuneus, precentral, para-hippocampal and calcarine cortices.Conclusion:Connectivity results showed that the expected emotional reward, based on odor perceived and processed in temporal lobes, was the main cue driving responses of impulsive children. This was followed by self-consciousness, the sensation of interaction with the surroundings and feelings of comfort and happiness, modulated by the precuneus together with somatosensory cortex and cingulum. Furthermore, reduced connectivity to frontal areas as well as to other sensory integration areas (piriform cortex), combined to show different sensory processing strategies for olfactory emotional cues in impulsive children. Finally, we hypothesize that the cerebellum plays a pivotal role in modulating decision-making for impulsive children.
Exosomal miR-214-5p Released from Glioblastoma Cells Modulates Inflammatory Response of Microglia after Lipopolysaccharide Stimulation through Targeting CXCR5
Authors: Yang Jian-kai , Liu Hong-jiang , Wang Yuanyu , Li Chen , Yang Ji-peng , Yang Liang , Qi Xue-jiao , Zhao Yin-long , Shi Xue-fang , Li Jing-chen , Sun Guo-zhu , Jiao Bao-hua 
Published: November 2018

Background and Objective: Exosomes communicate inter-cellularly and miRNAs play critical roles in this scenario. MiR-214-5p was implicated in multiple tumors with diverse functions uncovered. However, whether miR-214-5p is mechanistically involved in glioblastoma, especially via exosomal pathway, is still elusive. Here we sought to comprehensively address the critical role of exosomal miR-214-5p in glioblastoma (GBM) microenvironment.Methods:The relative expression of miR-214-5p was determined by real-time PCR. Cell viability and migration were measured by MTT and transwell chamber assays, respectively. The secretory cytokines were measured with ELISA kits. The regulatory effect of miR-214-5p on CXCR5 expression was interrogated by luciferase reporter assay. Protein level was analyzed by Western blot.Results:We demonstrated that miR-214-5p was aberrantly overexpressed in GBM and associated with poorer clinical prognosis. High level of miR-214-5p significantly contributed to cell proliferation and migration. GBM-derived exosomal miR-214-5p promoted inflammatory response in primary microglia upon lipopolysaccharide challenge. We further identified CXCR5 as the direct target of miR-214- 5p in this setting.Conclusion:Overexpression of miR-214-5p in GBM modulated the inflammatory response in microglia via exosomal transfer.
Antiproliferative Activity of microRNA-125a and its Molecular Targets
Authors: Russo Aniello , Potenza Nicoletta 
Published: November 2018

Background:MicroRNA-125a is present in all animals with bilateral symmetry and displays a conserved nucleotide sequence with a section of 11 bases including the seed region that is identical in all considered species. It primarily downregulates the expression of LIN28, thereby promoting cell differentiation and larval phase transitions in nematodes, mammals and insects.Objective:In this review, we focus on the cellular control of miR-125a expression and its antiproliferative activity.Results:In mammalians, microRNA-125a is present in most adult organs and tissues in which it targets proteins involved in the mitogenic response, such as membrane receptors, intracellular signal transducers, or transcription factors, with the overall effect of inhibiting cell proliferation. Tissue levels of miR-125a generally raise during differentiation but it is often downregulated in cancers, e.g. colon, cervical, gastric, ovarian, lung, and breast cancers, osteosarcoma, neuroblastoma, glioblastoma, medulloblastoma, retinoblastoma and hepatocellular carcinoma.Conclusion:The antiproliferative activity of miR-125a, demonstrated in many cell types, together with the notion that this miRNA is downregulated in several kinds of cancers, give a substantial support to the concept that miR-125a plays an oncosuppressive role.
How Adat Law Breaks The Cycle Of Vengeance: The Epkeret Tradition in Southern Buru
Authors: Siswanto Ari , Teslatu Leo Christy Menoha 
Published: November 2018

AbstractThis study was conducted on epkeret practice as an adat institution to resolve the conflict in South Buru. Specifically, the examined problems are how epkeret contributes to resolving inter-family conflicts and how the parties perceive epkeret. This study aims to identify the potential of epkeret as a customary dispute resolution. The research, which was mainly conducted using interview method, reveals that epkeret played an important role in preventing the cycle of violence in society. Another result obtained is that parties associated with epkeret have a positive perception of this adat institution.IntisariPenelitian ini dilakukan terhadap praktik epkeret sebagi pranata adat untuk menyelesaikan konflik di Buru Selatan. Secara lebih spesifik masalah yang diteliti adalah bagaimana kontribusi epkeret dalammenyelesaikan konflik antar-keluarga dan bagaimana pihak-pihak yang terkait mempersepsikan epkeret. Penelitian ini bertujuan mengidentifikasi potensi epkeret sebagai salah satu cara penyelesaian sengketa secara adat. Penelitian yang terutama dilakukan melalui metode wawancara ini mengungkapkan bahwa epkeret memainkan peran penting untuk mencegah siklus kekerasan di dalam masyarakat. Hasil lain yang diperoleh adalah bahwa pihak-pihak yang terkait dengan epkeret memiliki persepsi positif terhadap pranata adat ini.
Model Mitigasi Risiko pada Lembaga Penjamin Kredit di Indonesia
Authors: Zuleha Siti 
Published: November 2018

AbstractIn Indonesia there are two types of credit schemes, both credit with collateral and guarantee scheme. This study aims, describes the construction of credit-based credit agreement law and constructs a risk mitigation model.This study used a doctrinal approach that the data being studied is limited to secondary dominated by primary legal materials. Qualitative analysis method based on the theory of stage by testing the level of horizontal synchronization between the Insurance with the Guarantee Act. The results showed, credit with guarantee scheme is an expansion of the provisions of subrogation and debt coverage as stipulated in the Civil Code.IntisariDi Indonesia dikenal dua jenis skema kredit yang terdiri atas kredit dengan skema agunan (collateral)dan kredit dengan skema penjaminan. Penelitian ini bertujuan mendeskripsikan konstruksi hukumperjanjian kredit dan mengkonstruksi model mitigasi risiko pada lembaga penjamin kredit. Penelitiandilakukan dengan pendekatan doktrinal dan konsekuensianya data yang diteliti sebatas data sekunder yang didominasi oleh bahan hukum primer. Metode analisis kualitatif berbasis pada teori tangga dengan menguji taraf sinkronisasi horizontal antara Undang-Undang Perasuransian dengan Undang-Undang Penjaminan. Hasil penelitian menunjukkan, kredit dengan skema penjaminan merupakan perkembangan dari ketentuan subrogasi dan penanggungan utang menurut KUHPerdata. Namun lembaga ini memiliki kekhususunan berupa kewajiban mitigasi risiko.
Peran PTUN dan AUPB Menuju Tata Kelola Pemerintahan yang Baik (Good Governance)
Authors: Putrijanti Aju , Leonard Lapon T. , Utama Kartika Widya 
Published: November 2018

Abstract The Administrative Court has an important role to supervise the government’s duty, based on principle of good governance and regulations. Principles of good governance have been developed for some reasons. The aim of this research are to know the role of judge’s verdict and the development of principle of good governance. This research is use normative juridis method. The novelty is to strengthened the role of the judge’s verdict to build a good governance and to improve the knowledge of the importance of principles of good governance to build good governance.Intisari Pengadilan Tata Usaha Negara memiliki peran penting dalam melakukan pengawasan terhadap penyelenggaraan pemerintahan yang didasarkan pada pengujian terhadap Asas-asas Umum Pemerintahan yang Baik dan perundang-undangan. Asas-asas Umum Pemerintahan yang Baik telah mengalami perkembangan yang penting. Tujuan yang akan dicapai adalah untuk mengetahui peran putusan Hakim dan perkembangan Asas-asas Umum Pemerintahan yang Baik.Penelitian menggunakan metode yuridis normatif. Keterbaruan yaitu meningkatkan peran Pengadilan Tata Usaha Negara dan kemampuan untuk lebih memahami arti penting Asas-asas Umum Pemerintahan yang Baik menuju tata kelola yang lebih baik.
Kandungan Lemak, Koesterol dan Profile Asam-asam Lemak Daging Kerbau Yang Disuplementasi Pakan Campuran Garam Karboksilat Kering
Authors: Yurleni Yurleni , Priyantoi Rudi , Wiryawan Komang G 
Published: November 2018

Penelitian bertujuan untuk mengkaji pengaruh suplementasi campuran garam karboksilat kering (CGKK) yang berasal dari minyak ikan terhadap kandungan lemak, kolesterol dan profil asam-asam lemak daging kerbau. Daging berasal dari kerbau jantan umur 1,5-2 tahun yang dipelihara secara intensif selama 2,5 bulan dengan pemberian pakan hijauan 35% dan konsentrat 65%. Suplementasi CGKK berbahan dasar minyak ikan lemuru ditambahkan sebanyak 45 g/kg konsentrat. Setelah pemeliharaan ternak dipotong. Untuk analisa daging digunakan otot longissimus dorsi. Penelitian menggunakan rancangan acak lengkap apabila ada perbedaan di uji'dengan uji lanjut Least Square MeansModels (LSMEAN). Hasil penelitian memperlihatkan bahwa suplementasi CGKK menurunkan kandungan asam-asam lemak jenuh daging kerbau dan meningkatkan kandungan asam-asam lemak tak jenuh daging kerbau. Dapat disimpulkan bahwa suplementasi CGKK meningkatkan profil asam-asam lemak tak jenuh terutama asam lemak omega-3 yaitu EPA dan DHA.
Kata kunci : kerbau, suplementasi, minyak ikan, asam-asam lemak daging.
International Mobility Based on Women Labour: Study of Changes in Socio-Economic-Cultural Family Former migrant worker Jakatawa Bulaksari In the village, District Bantarsari, Cilacap Seen From the Perspective of Islamic Economic Theory
Authors: Haris Abdul , Azizah Siti Nur 
Published: November 2018

Migration is marked by international mobility occurs due to population growth which is not matched by the growth of employment. For women in the village who do not have a higher education and do not have a lot of skills, international mobility is a golden opportunity to improve their families' income. This issue is very complex but interesting to be studied. One of the purpose of this study was to Assess the social, economic, and cultural communities Jakatawa Bulaksari in general, particularly family / former international migrant workers (TKW) before becoming migrant workers, as well as how Islam views women migrant workers, it is well known that in Islam there are three pillars used to build the economic system in the Islamic view, that is how the wealth acquired over ownership (al-milkiyah), and how the management of property ownership (tasharruf fil milkiyah), as well as how the distribution of wealth in society (tauzi'ul tsarwah bayna an- Hoodoo). These three pillars, according to the researchers, the relevant applied in the case of Indonesian Workers (TKI), especially Labor Women (TKW) which is the object of this study were associated with changes in the behavior of economic, social, and cultural. This research was conducted by survey method is the explanation of descriptive research. This research was conducted in the area of Dusun Jakatawa, Bulaksari Village, District Bantarsari, Cilacap. Based on the findings availability of jobs in the hamlet jakatawa was very limited, coupled with limited human resources in the management of agricultural land, as well as the most supportive factor is the lifestyle of a consumer society, lack of education, which raises Hamlet jakatawa option for women to work outside the country.
Use of a subcutaneous ureteral bypass device for treatment of benign ureteral obstruction in cats: 174 ureters in 134 cats (2009–2015)
Authors: Berent Allyson C. , Weisse Chick W. , Bagley Demetrius H. , Lamb Kenneth 
Published: November 2018

Abstract
OBJECTIVE To determine outcomes of subcutaneous ureteral bypass (SUB) device placement for treatment of benign ureteral obstruction in cats.
DESIGN Retrospective case series.
ANIMALS 134 cats with SUB devices placed in 174 obstructed ureters during 144 hospitalizations.
PROCEDURES Medical records of cats that underwent SUB device placement for treatment of benign ureteral obstruction between 2009 and 2015 were reviewed. The SUB device was placed by use of fluoroscopic and surgical methods. Signalment, history, diagnostic imaging results, postprocedural results, duration of hospitalization, complications, and short- and long-term outcomes were recorded.
RESULTS Ureteral obstructions were caused by ureterolithiasis (114/174 [65.5%]), stricture (28/174 [16.1%]), both ureterolithiasis and stricture (29/174 [16.7%]), or pyonephrosis (1/174 [0.6%]); in 2 (1.1%) cats, the cause was not recorded. Fifty-two of the 134 (39%) cats had bilateral ureteral obstruction. At admission, 127 (95%) cats were azotemic. Median serum creatinine concentrations at admission and 3 months after SUB device placement were 6.6 and 2.6 mg/dL, respectively. Median renal pelvis diameters before and after the procedure were 9.2 and 1.5 mm, respectively. Postsurgical complications included device occlusion with blood clots (14/172 [8.1%]), device leakage (6/172 [3.5%]), and kinking of the device tubing (8/174 [4.6%]). Cats survived to hospital discharge after 135 of the 144 (94%) hospital admissions. The most common long-term complication was catheter mineralization (40/165 [24.2%]), which was documented a median of 463 days after device placement. A high postoperative serum ionized calcium concentration was significantly associated with SUB device occlusion.
CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that SUB device placement may be a viable option for treatment of cats with benign ureteral obstruction.
Noncardiogenic pulmonary edema associated with ozone exposure in three kittens
Authors: Caudal Victor , Whitty Justin , Snead Elisabeth C. R. , Starrak Gregory S. 
Published: November 2018

Abstract
CASE DESCRIPTION Three 21-week-old sexually intact female sibling domestic shorthair cats were brought to an emergency clinic because of signs of sudden respiratory distress that were noted by the owner after the cats had been confined for approximately 10 hours in a room with an operating ozone-generating air purifier. No other potential toxicant exposures were reported.
CLINICAL FINDINGS On initial examination, the 3 cats were severely dyspneic and tachypneic. Pulmonary crackles were audible on thoracic auscultation. Thoracic radiography revealed a marked peribronchial, unstructured interstitial pulmonary pattern that coalesced to a patchy alveolar pattern, consistent with noncardiogenic pulmonary edema.
TREATMENT AND OUTCOME A diuretic (furosemide, 2 mg/kg [0.9 mg/lb], IV) and bronchodilator (terbutaline sulfate, 0.01 mg/kg [0.005 mg/lb], IM) were administered, and supplemental oxygen was provided by placing the cats in an oxygen cage at 80% oxygen saturation. By 24 hours after placement in the oxygen cage, all cats had unremarkable respiratory rates and thoracic auscultation findings. Complete resolution of the respiratory signs and radiographic pulmonary lesions was achieved within 48 to 72 hours after initial evaluation. At a recheck examination performed 3 months after initial evaluation, the cats remained free of respiratory signs, and no radiographic pulmonary lesions were detected.
CLINICAL RELEVANCE To the authors’ knowledge, this was the first reported case of pulmonary toxicosis believed to have been caused by ozone exposure in cats. Associated respiratory signs were successfully and rapidly reversed following oxygen supplementation and medical treatment.
Krisis Ekonomi Krisis Politik Dunia Dan Ihsg
Authors: Ishak Ramli Vidyarto Nugroho, 
Published: November 2018

The global economic crisis of 2008-2010 had an impact on the global economic slowdown. Plus the political crisis in the countries of the Middle East region called the Arab Spring had become the center of world attention, because it also lowers economic conditions and corporate America and in other developing countries. By using daily data price of crude oil, the price of gold and exchange rates as well Rp./USD IDX Composite Index from the year 2010 - 2012, tested the impact of crude oil prices, global gold prices on the Stock Exchange Composite Index. The result was at the time of global economic and political crisis in oil prices and the world gold price positively affects JCI opposed to when normal conditions. When the economic crisis plus the political crisis that led to the oil price increases, the share price (CSPI) on the Stock Exchange also increased. Funds drawn investors from investing in the United States and other developing countries is invested in Indonesia so that stock prices rise along with oil prices and gold prices. While the exchange rate negatively affects Rp./USD JCI Stock Exchange, as a stronger rupiah lead JCI Stock Exchange also increased