bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term follow‐up of bulky classic Hodgkin lymphoma managed with ABVD and PET‐guided RT demonstrates excellent outcomes in PET‐negative cases
Authors: Kim J. L. , Villa D. , Tonseth R. P. , Gerrie A. S. , Wilson D. , Benard F. , Venner C. P. , Skinnider B. , Farinha P. , Slack G. W. , Lo A. C. , Scott D. W. , Sehn L. H. , Savage K. J. 
Published: November 2024

SummaryThe outcome of 221 patients with bulky (≥10 cm) classic Hodgkin lymphoma (cHL) treated with doxorubicin, bleomycin, vinblastine, dacarbazine and consolidative radiotherapy (RT) only in those with a positive end‐of‐treatment (EOT) positron emission tomography (PET) scan was evaluated. With a median follow‐up of 9.6 years, 5‐ and 10‐year progression‐free survival (PFS) in EOT PET‐negative cases were 94.0% and 90.4%, respectively, and in PET‐positive cases, 5/10‐year PFS was 64.6% (p < 0.001), with 15% overall receiving RT. Five‐year PFS for Deauville (D) score DX/D1–3 was 93.6%, compared with D4 66.7% (p < 0.001) and D5 33.3% (p < 0.001). Omission of RT in EOT PET‐negative cases is associated with excellent long‐term outcomes in bulky cHL.
Self‐compassion and psychological distress in chronic illness: A meta‐analysis
Authors: Baxter Rebecca , Sirois Fuschia M. 
Published: November 2024

AbstractObjectivesSelf‐compassion is a positive psychological factor linked to improved physical and psychological outcomes across different chronic illness populations. However, the extent to which self‐compassion contributes to reduced distress across different conditions or as a function of participant factors is not clear. The current meta‐analysis aimed to quantify the association between self‐compassion and psychological distress in different chronic illness populations and evaluate the factors that moderate this association.MethodsA systematic search of three electronic databases identified research reporting associations between self‐compassion and psychological distress in chronic illness. A random effects meta‐analysis was conducted to evaluate the association between self‐compassion and psychological distress. Moderator analyses were conducted for sample characteristics and distress types. A bespoke tool evaluated study quality.ResultsSearches yielded 51 eligible studies with 57 effect sizes. Meta‐analysis revealed that self‐compassion was negatively associated with psychological distress (r = −.516; 95% CIs [−.55, −.48]; p = .000). Moderator analyses were significant for distress type and chronic illness group, with effects being largest for stress and neurological conditions. Effects did not vary by sex, age or illness duration.ConclusionsFindings from this first comprehensive investigation of the link between self‐compassion and distress in chronic illness highlight the protective role of self‐compassion for chronic illness populations. These results lay the foundation for further research into understanding the processes that link self‐compassion to lower psychological distress, and that examine the effectiveness of self‐compassion interventions in chronic illness populations, to further advance knowledge and inform practice in this area.
Online support groups for family caregivers: A qualitative exploration of social support and engagement
Authors: Daynes‐Kearney Rosemary , Gallagher Stephen 
Published: November 2024

AbstractBackgroundThis qualitative research explored family caregivers’ engagement and social support in a single online support group (OSG). It sought to answer two research questions: Q1: Was social support evident in the OSG? If so what types and how did these types relate to engagement? Q2: Were elements from the Context, Content and Delivery conceptual framework evident in the OSG? If so, what were the key elements of this group?MethodsEighteen semi‐structured interviews were carried out with members of a family caregiver OSG in Ireland. Data were analysed using deductive qualitative analysis with a codebook created from one typology of social support and the Context, Content and Delivery conceptual framework for engagement in web‐based technologies.FindingsFor Q1, all types of social support were generated in the OSG. All had a positive impact on engagement. Informational support (17/18 respondents) and emotional support (15/18 respondents) were the highest support experienced by the group. For Q2, we found evidence for 11 key elements of the conceptual framework. Myriad sub‐elements had positive, negative and mixed impacts on engagement. These elements generally related to positive developments of social support by the respondents.ConclusionDrawing together the findings, we present a new framework, the Journey of Engagement and Support in Online Support Groups for Family Caregivers. This maps the stages for engagement and support in an OSG and can be used by practitioners for running OSG and researchers to generate testable hypotheses about the relationship between social support and engagement.
Needing to shout to be heard? Caregiver under‐responsivity and disconnection between vocal signaling and autonomic arousal in infants from chaotic households
Authors: Wass S. V. , Smith C. S. , Mirza F. U. , Greenwood E. M. G. , Goupil L. 
Published: November 2024

AbstractChildren raised in chaotic households show affect dysregulation during later childhood. To understand why, we took day‐long home recordings using microphones and autonomic monitors from 74 12‐month‐old infant–caregiver dyads (40% male, 60% white, data collected between 2018 and 2021). Caregivers in low‐Confusion Hubbub And Order Scale (chaos) households responded to negative affect infant vocalizations by changing their own arousal and vocalizing in response; but high‐chaos caregivers did not, whereas infants in low‐chaos households consistently produced clusters of negative vocalizations around peaks in their own arousal, high‐chaos infants did not. Their negative vocalizations were less tied to their own underlying arousal. Our data indicate that, in chaotic households, both communicating and responding are atypical: infants are not expressing their levels of arousal, and caregivers are under‐responsive to their infants' behavioral signals.
LGSur‐Net: A Local Gaussian Surface Representation Network for Upsampling Highly Sparse Point Cloud
Authors: Xiao Zijian , Zhou Tianchen , Yao Li 
Published: November 2024

AbstractWe introduce LGSur‐Net, an end‐to‐end deep learning architecture, engineered for the upsampling of sparse point clouds. LGSur‐Net harnesses a trainable Gaussian local representation by positioning a series of Gaussian functions on an oriented plane, complemented by the optimization of individual covariance matrices. The integration of parametric factors allows for the encoding of the plane's rotational dynamics and Gaussian weightings into a linear transformation matrix. Then we extract the feature maps from the point cloud and its adjoining edges and learn the local Gaussian depictions to accurately model the shape's local geometry through an attention‐based network. The Gaussian representation's inherent high‐order continuity endows LGSur‐Net with the natural ability to predict surface normals and support upsampling to any specified resolution. Comprehensive experiments validate that LGSur‐Net efficiently learns from sparse data inputs, surpassing the performance of existing state‐of‐the‐art upsampling methods. Our code is publicly available athttps://github.com/Rangiant5b72/LGSur-Net.
Revisiting the Normal Ranges of Aortic Valve Area in 2D Echocardiography and Its Association With Age, Sex, and Anthropometric Characteristics
Authors: Agahi Sadaf , Yaseri Mehdi , Eftekhari Mohammad Reza , Geraiely Babak , Sardari Akram , Sattarzadeh Badkoubeh Roya , Larti Farnoosh 
Published: November 2024

ABSTRACTPurposeDefining normative aortic echocardiographic values in each geographical district is crucial as aortic valve area (AVA) may vary across races, genders, and ages. Notably, variations in normal values can have implications for clinical decision‐making, and available data on the Middle East population is also scarce. We sought to establish normal ranges for aortic valve echocardiographic parameters in the Iranian population and assess the effect of age, gender, weight, height, BMI, BSA, and blood pressure on them.MethodsOur data were provided from the web‐based echocardiographic data registry of Imam Khomeini Hospital Complex (IKHC). A total of 3251 healthy subjects older than 18 years old without any valvular stenosis were included in our study.ResultsAVA's normal range was estimated at 1.92–4.52 and 1.67–3.80 cm2 in men and women, respectively. The annulus, AVA, AV VTI, and LVOT VTI were significantly larger in males, and this association remained significant after indexing AVA for weight, height, BMI, and BSA. Also, smaller AVA was associated with lower height, weight, BMI, and BSA in both men and women. Obese and hypertensive subjects had significantly larger AVA and annulus diameters.ConclusionOur study provided region‐specific normal reference values for AV echocardiographic parameters and compared them across genders, ages, BMI, and blood pressure groups in the Iranian population.
Re‐righting the law: The impact of VRA preclearance on language minorities
Authors: Harrison James M. , Gamino Aaron M. 
Published: November 2024

AbstractThe 1975 Voting Rights Act (VRA) extended voting rights protections to language minority groups. Employing a triple difference design, we find that language minority voter turnout remained stable in VRA‐shielded counties while it eroded elsewhere. This led to a reallocation of state educational funds away from unshielded counties. As a result, shielded counties experienced preferable changes in their high school graduation rates, white‐collar job attainment, and income. We find most of these differences were driven by the VRA's preclearance provision.
Further reduction in soil bacterial diversity under severe acidification in European temperate forests
Authors: Rousseau Mélody , Siegenthaler Andjin , Skidmore Andrew K. , de Groot G. Arjen , Laros Ivo 
Published: November 2024

AbstractDespite a decrease in industrial nitrogen and sulfur deposition over recent decades, soil acidification remains a persistent challenge to European forest health, especially in regions of intense agriculture and urbanisation. Using topsoil eDNA metabarcoding and functional annotations from a sample of 49 plots (each 30 × 30 m) located in The Netherlands and Germany, we investigated the effect of severe acidification on bacterial taxonomic diversity under different forest types and explored potential functional implications for nutrient cycling. Furthermore, we assessed which soil parameters known to influence soil bacterial communities affect these acidophilic communities. Here, we are the first to demonstrate under natural conditions that soil bacterial diversity in extremely acidic soils (pH <4.5) continues to decline similarly across forest types as pH further decreases under intensifying human activity. Our results confirmed pH as the key driver of soil bacterial communities, even in extremely acidic soils. Ongoing severe acidification continues to reduce bacterial communities, favouring taxa adapted to extreme acidity and primarily involved in recalcitrant carbon‐degradation compounds (e.g. cellulolysis potential = 0.78%–9.99%) while simultaneously diminishing taxa associated with nitrogen cycling (e.g. fixation potential = 6.72%–0.00%). Altogether, our findings indicate a further decline in bacterial diversity in already extremely acidic soils, likely disrupting nutrient cycling through changes in immobilisation and mineralisation processes. Our study highlights the continuous acidification of European temperate forests to extremely low pH levels, further disrupting forest ecosystem functioning. The significant reduction in bacterial diversity under such a severe acidification gradient, as demonstrated here, underscores the necessity to include severely acidified forests in conservation programmes and monitoring to prevent further degradation of European soils beyond repair.
CEO Connectedness and Firm Transparency
Authors: Luong Hoa , Minnick Kristina , Rivolta Mia L. , Shams Syed 
Published: November 2024

ABSTRACTOur research reveals that CEO connections with Audit Committee directors, established through past employment, education, or social organization memberships, significantly impact firm transparency. These connections increase the likelihood of firms issuing less transparent and readable financial reports. Furthermore, these connections are linked to decreased long‐term firm value and increased crash risk. Our findings underscore the crucial role of CEO connectedness in corporate disclosure transparency and firm value. We employed multiple methodologies to address endogeneity concerns. Our results remain robust.
Lysophosphatidylcholine Acyltransferase 2 Contributes to Increased Allergic and Irritant Inflammation in Mice
Authors: Kawasaki‐Nagano Midori , Tamagawa‐Mineoka Risa , Kurioka Tomoki , Arakawa Yukiyasu , Nakanishi Mari , Kishida Megumi , Nishigaki Hiromi , Hashidate‐Yoshida Tomomi , Shindou Hideo , Katoh Norito 
Published: November 2024

ABSTRACTPlatelet‐activating factor (PAF) is an important chemical mediator in the field of inflammation, but its function in the skin is unclear. To unravel the role of PAF, we focused on lysophosphatidylcholine acyltransferase 2 (LPCAT2 also called LPLAT9), a biosynthetic enzyme involved in PAF production, and investigated the role of PAF in allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). We measured the amount of PAF in the skin and investigated the ear swelling responses and leukocyte infiltration into the skin following the application of 2,4,6‐trinitro‐1‐chlorobenzene (TNCB) or croton oil in wild‐type (WT) and LPCAT2 knockout (LPCAT2‐KO) mice. The amount of PAF was increased in the skin of WT mice after TNCB or croton oil application but not detected in LPCAT2‐KO mice. The ear swelling response was decreased in LPCAT2‐KO mice compared with that in WT mice. In the ACD model, the numbers of lymphocytes, eosinophils, macrophages, mast cells and neutrophils were smaller in LPCAT2‐KO mice than in WT mice. In the ICD model, the ear swelling response was also decreased in LPCAT2‐KO mice compared with that in WT mice. When double staining of each inflammatory cell type and LPCAT2 was performed in ACD tissue, marked co‐staining of the eosinophil marker and LPCAT2 was observed. In addition, LPCAT2 expression was observed in the epidermis. These results indicate that PAF is involved in the infiltration of several cell types into the sites of allergic and non‐allergic skin inflammation. Furthermore, eosinophils and keratinocytes are primarily responsible for PAF production in skin inflammation.
The brain atlas of a subsocial bee reflects that of eusocial Hymenoptera
Authors: Pyenson Benjamin C. , Huisken Jesse L. , Gupta Nandini , Rehan Sandra M. 
Published: November 2024

AbstractThe evolutionary transition from solitary life to group‐living in a society with cooperative brood care, reproductive division of labor and morphological castes is associated with increased cognitive demands for task‐specialization. Associated with these demands, the brains of eusocial Hymenoptera divide transcriptomic signatures associated with foraging and reproduction to different populations of cells and also show diverse astrocyte and Kenyon cell types compared with solitary non‐hymenopteran insects. The neural architecture of subsocial bees, which represent evolutionary antecedent states to eusocial Hymenoptera, could then show how widely this eusocial brain is conserved across aculeate Hymenoptera. Using single‐nucleus transcriptomics, we have created an atlas of neuron and glial cell types from the brain of a subsocial insect, the small carpenter bee (Ceratina calcarata). The proportion of C. calcarata neurons related to the metabolism of classes of neurotransmitters is similar to that of other insects, whereas astrocyte and Kenyon cell types show highly similar gene expression patterns to those of eusocial Hymenoptera. In the winter, the transcriptomic signature across the brain reflected diapause. When the bee was active in the summer, however, genes upregulated in neurons reflected foraging, while the gene expression signature of glia associated with reproductive functions. Like eusocial Hymenoptera, we conclude that neural components for foraging and reproduction in C. calcarata are compartmentalized to different parts of its brain. Cellular examination of the brains of other solitary and subsocial insects can show the extent of neurobiological conservation across levels of social complexity.
Validation of selective catalytic BmCBP inhibitors that regulate the Bm30K‐24 protein expression in silkworm, Bombyx mori
Authors: Geng Jiasheng , Lu Weina , Kong Qinglong , Lv Jiao , Liu Yue , Zu Guowei , Chen Yanmei , Jiang Caiying , You Zhengying , Nie Zuoming 
Published: November 2024

AbstractThe cAMP response element binding protein (CREB)‐binding protein (CBP) is a histone acetyltransferase that plays an indispensable role in regulating the acetylation of histone and non‐histone proteins. Recently, it has been discovered that chemical inhibitors A485 and C646 can bind to Bombyx mori's CBP (BmCBP) and inhibit its acetyltransferase activity. Notably, the binding ability of A485 with BmCBP showed a very low Kd value of 48 nM by surface plasmon resonance (SPR) test. Further identification showed that both A485 and C646 can decrease the acetylation level of known substrate H3K27 and only 1 μM of A485 can almost completely inhibit the acetylation of H3K27, suggesting that A485 is an effective inhibitor of BmCBP's acetyltransferase activity. Moreover, it was confirmed that A485 could downregulate the expression of acetylated Bm30K‐24 protein at a post‐translational level through acetylation modification by BmCBP. Additionally, it was found that A485 can downregulate the stability of Bm30K‐24 and improve its ubiquitination level, suggesting that the acetylation modification by BmCBP could compete with ubiquitination modification at the same lysine site on Bm30K‐24, thereby affecting its protein stability. Here, we predict that A485 may be a potent CBP acetyltransferase inhibitor which could be utilized to inhibit acetyltransferase activity in insects, including silkworms.
Observation of Griffiths phase and giant magnetocaloric effect in double perovskite oxide RE2FeCrO6 (RE = Gd, Tb, Dy, Er)
Authors: Deng Siyu , Li Yue , Liu Xiansong , Feng Shuangjiu , Yang Hongling , Yang Jian , Jin Linghua , Kan Xucai , Wang Shouguo 
Published: November 2024

AbstractThe magnetic properties of double perovskite oxide RE2FeCrO6 (RE = GD, Tb, Dy, Er) were systematically studied, and the Griffiths phase evolution was observed. In Tb2FeCrO6, Dy2FeCrO6, and Er2FeCrO6, there are antiferromagnetic (AFM)‐ferromagnetic (FM) first‐order phase transition and the Griffiths phase with coexistence of FM and paramagnetic (PM) was observed by the EPR spectra. Gd2FeCrO6 has an AFM–PM second‐order phase transition, and there is no first‐order phase transition in the range of ∆H = 0–50 kOe. As the temperature decreases, all four sets of samples present χ−1 (T) deviates downwards from the Curie–Weiss linear behavior from 0.2 to 5 kOe, corresponding to the typical characteristics of Griffiths phase evolution. In addition, all four sets of samples have excellent magnetocaloric performance. Especially, the Gd2FeCrO6 oxide has giant magnetic entropy change and relative cooling power (−∆SMmax = 30.31 J/kg K and RCP = 312.8 J/kg when ∆H = 50 kOe). From the perspective of low‐temperature magnetic refrigeration application, the present work provides important candidate references for magnetic component researchers.
Out of Time, Pedagogy, Temporality and the Affective Encounter. Film and Moving Image Making Practice in Art Education
Authors: Fursman Joanna 
Published: November 2024

AbstractThis article explores how lens‐based practices can articulate and respond to art education phenomena. The affective turn in education and appearances of education in artists’ film and moving‐image are explored to help identify different appearances and experiences of art education pedagogy. Interspersed by clip descriptions from students and my affective descriptions of watching Être et avoir by Nicolas Philibert, and writing about a film made for the Freelands Foundation SHIFT series, I examine how using moving‐image practice to make a collaborative film in a college of further education in the West Midlands, England can dislocate art education pedagogy from Saul's parcelled and segmented time towards affective encounters and out‐of‐time, temporal experiences. Deleuze's time‐image film theory is explored to position pedagogy as a distinct, affective and temporal phenomena in Art Education and is used to compare the experience of both the making of and watching a film in an education context.
Unipolar Voltage for Better Characterizing Left Atrium Substrates: Comparing the Predictive Efficacy for Recurrence Post Atrial Fibrillation Ablation in a Post Hoc Analysis of STABLE‐SR‐III Trial
Authors: Qi Xiuyu , Chen Hongwu , Yang Gang , Liu Hailei , Wang Zidun , Jiang Xiaohong , Cui Chang , Cai Cheng , Ju Weizhu , Chen Minglong 
Published: November 2024

ABSTRACTBackgroundWhile bipolar voltage (BV) is acknowledged as an indicator of viable cardiomyocyte activation, unipolar recording has emerged as an alternative technique due to its advantage of providing a wider field of view. This study aims to compare the efficacy of unipolar voltage (UV) versus BV in predicting ablation recurrence in atrial fibrillation patients.MethodsIn Substrate Ablation in the Left Atrium during Sinus Rhythm Trial III, 375 patients completed the follow‐up with preserved mapping data were included in the analysis. For each patient, the mean UV and BV was obtained from the electrograms sampled in left atrium (LA).ResultsTotally 301 patients experience the primary endpoint within 23.0 ± 9.2 months. While both low UV and BV had significant associations with long‐term recurrence of atrial tachyarrhythmia (ATa), only mean UV was independently associated with the outcome. The model by UV with ablation feature had higher discriminatory power to predict ATa recurrence compared with BV model (area under the curve [AUC]: 0.858 vs. 0.757, p < 0.001). In subgroup analysis, UV reveals more powerful predictive efficacy compared with BV, with the AUC 0.843 versus 0.751 (p < 0.001) in circumferential pulmonary vein isolation (CPVI) alone cohort and 0.882 versus 0.750 (p < 0.001) in CPVI plus cohort, respectively.ConclusionUV exhibits higher efficacy for predicting long‐term ATa recurrence after ablation compared with BV in elderly patients with atrial fibrillation regardless of whether the patient accepts substrate modification. The outcome suggests that unipolar recording may better characterize LA fibrosis by capturing more comprehensive transmural features than bipolar signals.Clinical Trial RegistrationClinicalTrials.gov; URL: https://www.clinicaltrials.gov. Unique Identifier: NCT03462628.