bluuebunny/crossref_metadata_2025_split huggingface dataset:
The specific absorption rate in different brain regions of rats exposed to electromagnetic plane waves
Authors: Wang Hao-Yu , Li Chun-Fang , Yu Chao , Dong Ji , Zou Yong , Nie Bin-Bin , Li Jia-Kai , Ma Lin , Peng Rui-Yun 
Published: September 2019

AbstractAccurate dosimetry of a specific brain region in rats exposed to an electromagnetic field (EMF) is essential for studies focusing on dose-effect relationship of the region. However, only dosimetry of whole brain or whole body were evaluated in most of previous studies. In this study, a numerical voxel rat model with 10 segmented brain regions was constructed. Then, the effects of frequency, incidence direction, and E-polarization direction of plane wave EMF on brain region averaged specific absorption rate (BRSAR) of rats were investigated. At last, the reliability of using whole-body averaged SAR (WBDSAR) and whole-brain averaged SAR (WBRSAR) as estimations of BRSAR were also evaluated. Our results demonstrated that the BRSAR depended on the frequency, incidence direction, and E-polarization direction of the EMF. Besides, the largest deviation could be up to 13.1 dB between BRSAR and WBDSAR and 9.59 dB between BRSAR and WBRSAR. The results suggested that to establish an accurate dose-effect relationship, the variance of the BRSAR induced by alteration of frequency, incidence direction, and E-polarization direction of EMF should be avoided or carefully evaluated. Furthermore, the use of WBDSAR and WBRSAR as estimations of BRSAR should be restricted to certain conditions such that the deviations are not too large.
Implicit and explicit systems differently predict possible dangers
Authors: Manassero Eugenio , Mana Ludovica , Concina Giulia , Renna Annamaria , Sacchetti Benedetto 
Published: September 2019

AbstractOne strategy to address new potential dangers is to generate defensive responses to stimuli that remind learned threats, a phenomenon called fear generalization. During a threatening experience, the brain encodes implicit and explicit memory traces. Nevertheless, there is a lack of studies comparing implicit and explicit response patterns to novel stimuli. Here, by adopting a discriminative threat conditioning paradigm and a two-alternative forced-choice recognition task, we found that the implicit reactions were selectively elicited by the learned threat and not by a novel similar but perceptually discriminable stimulus. Conversely, subjects explicitly misidentified the same novel stimulus as the learned threat. This generalization response was not due to stress-related interference with learning, but related to the embedded threatening value. Therefore, we suggest a dissociation between implicit and explicit threat recognition profiles and propose that the generalization of explicit responses stems from a flexible cognitive mechanism dedicated to the prediction of danger.
A Pixelated Microwave Near-Field Sensor for Precise Characterization of Dielectric Materials
Authors: Saadat-Safa Maryam , Nayyeri Vahid , Ghadimi Ali , Soleimani Mohammad , Ramahi Omar M. 
Published: September 2019

AbstractA highly sensitive microwave near-field sensor based on electrically-small planar resonators is proposed for highly accurate characterization of dielectric materials. The proposed sensor was developed in a robust complete-cycle topology optimization procedure wherein first the sensing area was pixelated. By maximizing the sensitivity as our goal, a binary particle swarm optimization algorithm was applied to determine whether each pixel is metalized or not. The outcome of the optimization is a pixelated pattern of the resonator yielding the maximum possible sensitivity. A curve fitting method was applied to the full-wave simulation results to derive a closed form expression for extracting the dielectric constant of a chemical material from the shift in the resonance frequency of the sensor. As a proof of concept, the sensor was fabricated and used to measure the permittivity of two known liquids (cyclohexane and chloroform) and their mixtures with different volume ratios. The experimentally extracted dielectric constants were in an excellent agreement with the reference data (for pure cyclohexane and chloroform) or those obtained by mixture formulas.
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor
Authors: Xu Menglin , Shao Xinyu , Kuai Xiaoyi , Zhang Liping , Zhou Chunli , Cheng Zhengwu 
Published: September 2019

AbstractGastrointestinal cancers have become increasingly prevalent worldwide. Previous studies have reported an oncogenic function of Rab1A in colorectal cancer and hepatocellular carcinomas via the mTOR pathway. However, the exact role of Rab1A in gastrointestinal cancers remains elusive. We detected significantly higher expression of Rab1A in the gastrointestinal tumor tissues compared to that in other cancer types following an in silico analysis of TGCA and GTEX databases. Furthermore, Rab1A was overexpressed in the gastrointestinal tumor tissues compared to the para-tumor tissues. Although Rab1A expression levels were not associated with the tumor-lymph node-metastasis (TNM) stage, Rab1A overexpression in the tumor tissues of a gastric cancer (GC) cohort was strongly correlated with poor prognosis in the patients. In addition, Rab1A knockdown significantly inhibited the in vitro proliferation and migration abilities of GC cells, as well as the growth of GC xenografts in vivo. Furthermore, a positive correlation was observed between Rab1A expression levels and that of different upstream/downstream mTOR targets. Taken together, Rab1A regulates the PI3K-AKT-mTORC1 pathway through the mTORC1 complex consisting of mTORC1, Rheb and Rab1A, and is a promising therapeutic target in GC.
Time evolution of Symmetry-forbidden Raman lines activated by photorefractivity
Authors: Kokanyan Ninel , Bazzan Marco , Vittadello Laura , Chapron David , Kokanyan Edvard , Fontana Marc D. 
Published: September 2019

AbstractTransmission Raman spectroscopy experiments were performed on iron doped congruent lithium niobate within two –in principle equivalent- configurations, namely Y(ZX)Y and Y(XZ)Y. While the former respects the Raman selection rules, the other configuration gives a time dependent spectrum that, after a transient time of several minutes, finally results in a mixture of expected and forbidden modes. This breaking of Raman selection rules is caused by the spontaneous conversion of a part of the ordinarily polarized pump beam into an extraordinarily polarized beam by photorefractive anisotropic self-scattering. A numerical modelling of the phenomenon is developed and fairly reproduces the time dependence of conversion energy.
Effectiveness of hypnosis for pain management and promotion of health-related quality-of-life among people with haemophilia: a randomised controlled pilot trial
Authors: Paredes Ana Cristina , Costa Patrício , Fernandes Susana , Lopes Manuela , Carvalho Manuela , Almeida Armando , Pinto Patrícia Ribeiro 
Published: September 2019

AbstractJoint deterioration and associated chronic pain are common among people with haemophilia (PWH), having an impact on quality-of-life. Though non-pharmacological strategies are recommended, psychological interventions to promote pain control and quality-of-life have scarcely been tested in haemophilia. This randomised controlled pilot trial aimed to assess feasibility, acceptability and effectiveness of hypnosis for pain management and promotion of health-related quality-of-life (HRQoL) among PWH. Twenty adults were randomised either to four weekly hypnosis sessions plus treatment-as-usual (experimental group; EG) or treatment-as-usual only (control group; CG). Participants completed sociodemographic and clinical assessment, measures of pain, HRQoL and emotional distress before (T1) and after (T2) intervention. Changes were analysed by calculating the differences between T1 and T2, and the groups were compared through independent-sample t tests (or chi-squared). Retention rates (90%) and analysis of patient satisfaction showed good acceptability and feasibility of the intervention. The EG (n = 8) had a higher reduction on pain interference than the CG (n = 10) (d = −0.267). A higher improvement on HRQoL (EQ-5D index: d = 0.334; EQ-5D VAS: d = 1.437) and a tendency towards better haemophilia-related quality-of-life (A36-Hemofilia QoL) were also evident in the EG. This is the first study showing the effectiveness of hypnosis to reduce pain interference and promote HRQoL among PWH.
The inhibition effect mechanisms of four scale inhibitors on the formation and crystal growth of CaCO3 in solution
Authors: Li Changjun , Zhang Chaoyi , Zhang Wuping 
Published: September 2019

AbstractThe experimentation, molecular dynamics simulation and DFT calculation were used to study the inhibition effects of four scale inhibitors, including polyacrylic acid (PAA), hydrolyzed polymaleic anhydride (HPMA), polyepoxysuccinic acid (PESA) and polyaspartic acid (PASP), on formation and crystal growth of CaCO3 in solutions. According to concentrations of Ca2+ in solutions, the sequence of inhibition effects of scale inhibitors on formation of CaCO3 in the solution was PESA > PASP > HPMA > PAA. Characterization of CaCO3 crystals by XRD and a laser particle size analyzer indicated that the sequence of inhibition effects of scale inhibitors on crystal growth of CaCO3 in solutions was PESA > HPMA > PASP > PAA. Interaction energies between the scale inhibitor molecule and Ca2+, and between the scale inhibitor molecule and the CaCO3 (104) surface indicated that the difference of the inhibition effects was derived from the difference in the interaction energy. The results of DFT calculation indicated that the difference between the interaction energies of these inhibitors and Ca2+ was derived from differences of number and the Mulliken population values of the chemical bonds which formed between the inhibitor molecule and Ca2+ and between the inhibitor molecule and the CaCO3 surface.
The impact of short-term incentives on physical activity in a UK behavioural incentives programme
Authors: Hajat Cother , Hasan Ali , Subel Shaun , Noach Adam 
Published: September 2019

AbstractThis observational study investigates whether the provision of ongoing short-term-incentives for verified physical activity increases and sustains levels of physical activity. We compared UK members at baseline (years 1 and 2) prior to Vitality’s Active Rewards (VAR) intervention commencing (year 3) and follow-up (year 4) for verified, self-reported (encompassing additional physical activities), mortality relative risk and satisfaction with physical activity. Members were categorised into low-active, medium-active and high-active by tertiles of baseline physical activity. Of 11,881 participants, 6477(54.5%) were male, with mean age 39.7(SD 9.8) years. At follow-up, annual active days had increased by 56% overall [60.8(59.7–61.9)–94.8(93.0–96.5)]; 554% in low-active [8.5(8.3–8.7)–47.1(44.7–49.5)]; 205% in medium-active [39.8(39.4–40.2)–81.4(78.7–84.1)] and 17% in high-active members [131.7(129.9–133.5)–153.7(150.7–156.7)] (all p < 0.001). Annual weeks of attaining international physical activity recommendations increased by 19% overall [22.2(42.8%)–26.4(50.8%)] and by 316% for low-active members [4.9(9.5%)–15.5(29.8%)]. Self-reported active minutes/week increased by 45% overall [1423(139.4–145.2)–207.0(201.8–212.3)] and 712% in low-active members [20.1(19.3–21.0)–143.2(134.6–151.9)]. Happiness with exercise levels also increased from 1985(49.4%) to 3414(84.9%) members (all p < 0.001). The relative risk of mortality from a lack of physical activity reduced by 7% for low-active members [from 0.99 to 0.92], 5% for medium-active [0.94–0.89] and 3% for high-active [0.89–0.86](p < 0.001) and by 0.02% for each additional year of age (p = 0.02). This large-scale, real-world, short-term-incentives intervention led to a dramatic increase in physical activity which was sustained for, and still increasing after, two years. If applied at broader level, this approach could considerably aid progress towards WHO targets in its Global Action Plan for Physical Activity.
Centrosomal cohesion deficits as cellular biomarker in lymphoblastoid cell lines from LRRK2 Parkinson's disease patients
Authors: Fernández Belén , Lara Ordóñez Antonio Jesús , Fdez Elena , Mutez Eugénie , Comptdaer Thomas , Leghay Coline , Kreisler Alexandre , Simonin Clémence , Vandewynckel Laurine , Defebvre Luc , Destée Alain , Bleuse Séverine , Taymans Jean-Marc , Chartier-Harlin Marie-Christine , Hilfiker Sabine 
Published: September 2019

Abstract
Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for the treatment of Parkinson's disease (PD), and orally bioavailable, brain penetrant and highly potent LRRK2 kinase inhibitors are in early stages of clinical testing. Detection of LRRK2 phosphorylation, as well as phosphorylation of Rab10, a LRRK2 kinase substrate, have been proposed as target engagement biomarkers for LRRK2 inhibitor clinical trials. However, these readouts do not seem able to stratify patients based on enhanced LRRK2 kinase activity. Here, we describe a robust cell biological assay based on centrosomal cohesion alterations which were observed in peripheral blood mononuclear cell-derived lymphoblastoid cell lines (LCLs) from patients with G2019S LRRK2 mutations as compared with healthy controls, and could also be detected in a subset of sporadic PD patient samples. We suggest that LCLs may be a valuable resource for LRRK2 research, and that determination of centrosomal cohesion deficits may assist in the stratification of a subset of sporadic PD patients.
Rhyme Production Strategies Distinguish Stuttering Recovery and Persistence
Authors: Gerwin Katelyn , Brosseau-Lapré Françoise , Brown Barbara , Christ Sharon , Weber Christine 
Published: September 2019

Purpose
The primary aim of the current study was to examine the developing phonological awareness of 4- to 5-year-old children who stutter (CWS) in relation to eventual recovery (CWS-eRec) or persistance (CWS-ePer) in stuttering, accounting for the presence of typical speech (TS) production or speech sound disorder (SSD).

Method

In the 1st year of a 5-year longitudinal study, 37 children who do not stutter (CWNS) and 48 CWS completed a rhyme discrimination and a rhyme production task from the Phonological Awareness Test–Second Edition (
Robertson & Salter, 2007
). Using data from their last year of participation, CWS were classified into CWS-ePer and CWS-eRec. Each CWS group was further divided into TS and SSD groups based on speech production abilities at the time of the rhyme tasks. Accuracy on the rhyme tasks was compared. Groups were also compared on strategies used to generate correct and incorrect responses for the rhyme production task (e.g., real-word correct, nonword correct, semantic association, repeated cues).

Results
All groups performed similarly on the rhyme discrimination task. On the rhyme production task, CWS-ePer-SSD and CWS-eRec-SSD performed with less accuracy than CWNS, but CWS-ePer-TS, CWS-eRec-TS, and CWNS achieved similar task accuracy. On correct rhyme production trials, CWS-ePer-TS created more nonword rhymes than real-word rhymes. CWS-ePer-TS used the nonword strategy at 1.88 times the CWNS rate. CWS-eRec-TS fell between CWS-ePer-TS and CWNS in use of the nonword strategy.

Conclusions
Reliance on a nonword strategy for rhyme production in CWS-ePer-TS may reflect differences in underlying phonological representations and ease of phonological access to the lexicon compared to CWNS.
Objective Intelligibility Assessment by Automated Segmental and Suprasegmental Listening Error Analysis
Authors: Jiao Yishan , LaCross Amy , Berisha Visar , Liss Julie 
Published: September 2019

Purpose
Subjective speech intelligibility assessment is often preferred over more objective approaches that rely on transcript scoring. This is, in part, because of the intensive manual labor associated with extracting objective metrics from transcribed speech. In this study, we propose an automated approach for scoring transcripts that provides a holistic and objective representation of intelligibility degradation stemming from both segmental and suprasegmental contributions, and that corresponds with human perception.

Method
Phrases produced by 73 speakers with dysarthria were orthographically transcribed by 819 listeners via Mechanical Turk, resulting in 63,840 phrase transcriptions. A protocol was developed to filter the transcripts, which were then automatically analyzed using novel algorithms developed for measuring phoneme and lexical segmentation errors. The results were compared with manual labels on a randomly selected sample set of 40 transcribed phrases to assess validity. A linear regression analysis was conducted to examine how well the automated metrics predict a perceptual rating of severity and word accuracy.

Results
On the sample set, the automated metrics achieved 0.90 correlation coefficients with manual labels on measuring phoneme errors, and 100% accuracy on identifying and coding lexical segmentation errors. Linear regression models found that the estimated metrics could predict a significant portion of the variance in perceptual severity and word accuracy.

Conclusions
The results show the promising development of an objective speech intelligibility assessment that identifies intelligibility degradation on multiple levels of analysis.
The s process in rotating low-mass AGB stars
Authors: den Hartogh J. W. , Hirschi R. , Lugaro M. , Doherty C. L. , Battino U. , Herwig F. , Pignatari M. , Eggenberger P. 
Published: September 2019

Aims. We investigate the s-process during the AGB phase of stellar models whose cores are enforced to rotate at rates consistent with asteroseismology observations of their progenitors and successors.
Methods. We calculated new 2 M⊙, Z = 0.01 models, rotating at 0, 125, and 250 km s−1 at the start of main sequence. An artificial, additional viscosity was added to enhance the transport of angular momentum in order to reduce the core rotation rates to be in agreement with asteroseismology observations. We compared rotation rates of our models with observed rotation rates during the MS up to the end of core He burning, and the white dwarf phase.
Results. We present nucleosynthesis calculations for these rotating AGB models that were enforced to match the asteroseismic constraints on rotation rates of MS, RGB, He-burning, and WD stars. In particular, we calculated one model that matches the upper limit of observed rotation rates of core He-burning stars and we also included a model that rotates one order of magnitude faster than the upper limit of the observations. The s-process production in both of these models is comparable to that of non-rotating models.
Conclusions. Slowing down the core rotation rate in stars to match the above mentioned asteroseismic constraints reduces the rotationally induced mixing processes to the point that they have no effect on the s-process nucleosynthesis. This result is independent of the initial rotation rate of the stellar evolution model. However, there are uncertainties remaining in the treatment of rotation in stellar evolution, which need to be reduced in order to confirm our conclusions, including the physical nature of our approach to reduce the core rotation rates of our models, and magnetic processes.
A Systematic Review on the Value of Infrared Thermography in the Early Detection of Periprosthetic Joint Infections
Authors: Scheidt Sebastian , Rüwald Julian , Schildberg Frank Alexander , Mahlein Anne Katrin , Seuser Axel , Wirtz Dieter Christian , Jacobs Cornelius 
Published: September 2019

AbstractBackground Variations in the temperature of body and skin are symptoms of many pathological changes. Although joint replacement surgery of hip and knee has been very successful in recent decades, periprosthetic infection is a growing problem and the number one reason for revision. While many studies have investigated changes in blood levels, investigation of temperature has not been performed on a regular basis. The objective of this work is to determine whether reference literature exists for the infrared thermographic examination in knee and hip arthroplasty and if reference values can be derived for the methodology or if there is a peri- and postoperative benefit.Material und Methods By means of a systematic online database search and based on the Cochrane, PICOT and PRISMA guidelines, this systematic review retrieved 254 studies. All publications with thermographic examination in arthroplasty of the hip and knee were imbedded. 249 studies were excluded due to the defined inclusion and exclusion criteria and five studies with 251 patients have finally been included in the evaluation process. This was followed by an analysis and discussion of the methodology.Results and Conclusion Infrared thermography is a useful tool in the perioperative care of patients after arthroplasty of the knee and hip joint. The technology is portable, easy to use and non-invasive. Based only on these few publications, values can be derived, which provide a guidance for the thermographic aftercare in arthroplasty surgery.
Clinical Study of Bell's Palsy at Tertiary Care: Our Experience
Authors: Bharathi M. B. , Unisa Thanzeem , Chandresh Swathi , R. Venkatesh C. , S. Harsha 
Published: September 2019

Abstract
Introduction Bell's palsy (BP) is the common cause of facial palsy. This study aims to report and analyze the age, sex distribution, symptomatology, site of lesion, and prognosis in 101 patients with (BP).
Materials and Methods This is a cross-sectional study conducted at tertiary referral center, JSS Hospital, Mysuru. All patients consenting to participate in this study, of all ages, of either sex, both outpatients and inpatients with a diagnosis of BP during this study period were included.
Results Of the 101 patients analyzed, maximum cases (25.7%) were in third decade of age; 55.4% were males, and both right and left sides of the face were equally involved. Maximum number of patients (50.5%) had a history of postaural pain at presentation Topodiagnostic tests showed majority of BP cases involving geniculate or suprageniculate regions (67.3%) in our study. 20.8% had lesion above the nerve to stapedius, and 11.9% had lesion below the nerve to stapedius. Electrodiagnostic test—electroneuromyography (ENMG)—was abnormal in 57 (67.1%) individuals at day 4. 50.4% of patients had a House-Brackmann (HB) facial nerve grade IV at presentation. 90% of the BP group in our study recovered normal to near-normal facial nerve function by the end of 28 days’ time.
Conclusion Each case of BP should be evaluated with thorough clinical examination, topodiagnostic tests, and electrodiagnostic tests. Appropriate management will help in almost full recovery of disease.