bluuebunny/crossref_metadata_2025_split huggingface dataset:
When a phenotype is not the genotype: Implications of phenotype misclassification and pedigree errors in genomics-assisted breeding of sweetpotato [Ipomoea batatas(L.) Lam.]
Authors: Gemenet Dorcus C. , De Boeck Bert , Da Silva Pereira Guilherme , Kitavi Mercy N. , Ssali Reuben T. , Utoblo Obaiya , Swanckaert Jolien , Carey Edward , Gruneberg Wolfgang , Yada Benard , Yencho Craig , Mwanga Robert O. M. 
Published: August 2019

AbstractExperimental error, especially through genotype misclassification and pedigree errors, negatively affects breeding decisions by creating ‘noise’ that compounds the genetic signals for selection. Unlike genotype-by-environment interactions, for which different methods have been proposed to address, the effect of ‘noise’ due to pedigree errors and misclassification has not received much attention in most crops. We used two case studies in sweetpotato, based on data from the International Potato Center’s breeding program to estimate the level of phenotype misclassification and pedigree error and to demonstrate the consequences of such errors when combining phenotypes with the respective genotypes. In the first case study, 27.7% phenotype misclassification was observed when moving genotypes from a diversity panel throughin-vitro, screenhouse and field trialing. Additionally, 22.7% pedigree error was observed from misclassification between and within families. The second case study involving multi-environment testing of a full-sib population and quantitative trait loci (QTL) mapping showed reduced genetic correlations among pairs of environments in mega-environments with higher phenotype misclassification errors when compared to the mega-environments with lower phenotype misclassification errors. Additionally, no QTL could be identified in the low genetic correlation mega-environments. Simulation analysis indicated that phenotype misclassification was more detrimental to QTL detection when compared to missingness in data. The current information is important to inform current and future breeding activities involving genomic-assisted breeding decisions in sweetpotato, and to facilitate putting in place improved workflows that minimize phenotype misclassification and pedigree errors.
A machine learning and network framework to discover new indications for small molecules
Authors: Gilvary Coryandar , Elkhader Jamal , Madhukar Neel , Henchcliffe Claire , Goncalves Marcus D. , Elemento Olivier 
Published: August 2019

AbstractDrug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g. Viagra) or experimental-based repurposing screens, which are costly, time-consuming, and imprecise. Recently, more systematic computational approaches have been proposed, however these rely on utilizing the information from the diseases a drug is already approved to treat. This inherently limits the algorithms, making them unusable for investigational molecules. Here, we present a computational approach to drug repurposing, CATNIP, that requires only biological and chemical information of a molecule. CATNIP is trained with 2,576 diverse small molecules and uses 16 different drug similarity features, such as structural, target, or pathway based similarity. This model obtains significant predictive power (AUC = 0.841). Using our model, we created a repurposing network to identify broad scale repurposing opportunities between drug types. By exploiting this network, we identified literature-supported repurposing candidates, such as the use of systemic hormonal preparations for the treatment of respiratory illnesses. Furthermore, we demonstrated that we can use our approach to identify novel uses for defined drug classes. We found that adrenergic uptake inhibitors, specifically amitriptyline and trimipramine, could be potential therapies for Parkinson’s disease. Additionally, using CATNIP, we predicted the kinase inhibitor, vandetanib, as a possible treatment for Type 2 Diabetes. Overall, this systematic approach to drug repurposing lays the groundwork to streamline future drug development efforts.
Bivariate analysis of barley scald resistance with relative maturity reveals a new major QTL on chromosome 3H
Authors: Zhang Xuechen , Ovenden Ben , Orchard Beverley A. , Zhou Meixue , Park Robert F. , Singh Davinder , Milgate Andrew 
Published: August 2019

AbstractThe disease scald of barley is caused by the pathogen Rhynchosporium commune and can cause up to 30-40% yield loss in susceptible varieties. In this study, the Australian barley cultivar Yerong was demonstrated to have resistance that differed from Turk (Rrs1) based on seedling tests with 11 R. commune isolates. A doubled haploid population with 177 lines derived from a cross between Yerong and Franklin was used to identify quantitative trait loci (QTL) for scald resistance. Scald resistance against four pathogen isolates was assessed at the seedling growth stage in a glasshouse experiment and at the adult growth stage in field experiments with natural infection over three consecutive years. A QTL on chromosome 3H was identified with large effect, consistent with a major gene conferring scald resistance at the seedling stage. Under field conditions, scald percentage was negatively correlated with early relative maturity. A bivariate analysis was used to model scald percentage and relative maturity together, residuals from the regression of scald percentage on relative maturity were used as our phenotype for QTL analysis. This analysis identified one major QTL on chromosome 3H, which mapped to the same position as the QTL identified for scald resistance at seedling stage. The identified QTL on 3H is proposed to be different from the Rrs1 on the basis of seedling resistance against different R. commune isolates and physical map position. The analysis also identified an additional novel QTL on chromosome 7H. This study increases the current understanding of scald resistance and identifies genetic material possessing QTLs useful for the marker-assisted selection of scald resistance in barley breeding programs.
The effect of motivators, supply, and lean management on sustainable supply chain management practices and performance
Authors: Baliga Ravindra , Raut Rakesh , Kamble Sachin 
Published: August 2019

PurposeThe purpose of this paper is to conceptualize a model for sustainable supply chain management (SSCM) that integrates the antecedents, practices and performance measures of sustainability. It also examines if lean management (LM) and supply management (SM) are antecedents of SSCM.Design/methodology/approachA systematic review of literature was undertaken across multiple streams, including operations management, SCM, sustainability, business ethics and performance management. Articles relevant to SSCM published over a span of 31 years (1988–2018) were searched using keywords and specific selection criteria.FindingsFrom the literature, three dependent constructs – motivators of sustainability, LM and SM – and three independent constructs – environmental practices in SCM, social practices in SCM and SSCM performance – are identified and defined. Linkages between these constructs are hypothesized to develop a theoretical framework called the “integrated lean/supply management with sustainability motivators, practices and performance model.”Research limitations/implicationsBuilt on the principles-practices-outcomes framework proposed earlier, this model is comprehensive in its coverage of sustainability antecedents, practices and performance. Further, it covers the SCM triad – the supplier, the focal firm and the customers – as well as the roles they play in sustainability performance.Originality/valueBy identifying LM and SM as additional antecedents of SSCM, this study suggests that sustainability may be realized through LM and SM principles. Further, the proposed model presents a novel integration of literature from diverse domains.
Diffusion of innovation in a contractor company
Authors: Lundberg Mary , Engström Susanne , Lidelöw Helena 
Published: August 2019

Purpose
In the construction industry, it has proven difficult to implement and realize innovation efforts, for example in the development of industrialized construction and use of platform concepts. Thus, the purpose of this study is to characterize the innovation diffusion process in the social system of a large Swedish contractor company. Specifically, the diffusion of three innovative industrialized house-building (IHB) platforms and factors affecting their adoption and implementation (particularly effects of their perceived radicality in relation to the company’s decentralized characteristics) are identified and discussed.

Design/methodology/approach
A case study approach was applied, using empirical material including semi-structured interviews and archival records (research reports from earlier studies at different points in time related to each innovation and annual corporate reports). The material was analyzed using Rogers’ (2003) five-stage innovation process model, acknowledging the importance of social systems’ structures.

Findings
Structural characteristics of the social system strongly affect innovation diffusion. In subsystems that had not been involved in initiation of the innovations, they were regarded as radical, which hindered their adoption and implementation.

Research limitations/implications
This study builds upon the recent findings that successful innovation implementation depends on a range of contingencies in the construction context. Although the diffusion of the innovations per se has been traced over a ten-year period, generalizability is limited because the results come from one construction company.

Practical implications
Contractors have invested substantially in the development of industrialized construction and use of platform concepts, but less in their implementation, so they have obtained little gain. How innovations are perceived and implemented in different subsystems affects the success of their implementation in the overarching social system.

Originality/value
This study adheres to previous calls for more research on firm level in the complex social system of construction companies by adopting a ten-year perspective on the diffusion of innovation at a large contractor addressing in particular the impact of the innovations perceived radicality in relation to the decentralized characteristics of the company.
Senior citizens’ requirements of services provided by community-based care facilities: a China study
Authors: Xiang Liqun , Yu Ann T.W. , Tan Yongtao , Shan Xuezhu , Shen QiPing 
Published: August 2019

PurposeThis study aims to identify senior citizens’ requirements related to “embedded retirement facilities (ERFs)”, which are small-scale, multi-functional and community-based care facilities for senior citizens in mainland China, and to discuss whether senior citizens’ perceptions are influenced by their backgrounds.Design/methodology/approachA questionnaire type of research was administrated to gain senior citizens’ rankings of services that should be provided by ERFs. Non-parametric statistical models were applied to analyse the collected data.FindingsResults reveal that health care services for senior citizens are considered the most important. Requirements regarding rehabilitation and entertainment and daily life assistance are ranked second and third, respectively. Culture-related activities are the least important. Differences in the senior citizens’ background also influence their choices.Research limitations/implicationsThis research is based on a questionnaire survey completed in northeast China. Opinions from other areas of mainland China will be collected in the future study. Furthermore, the key items identified in this research, which was completed by participants from the built environment discipline, can be further elaborated by combining interdisciplinary feedback.Practical implicationsThis study explores services that are supposedly provided by ERFs. Findings will provide useful perceptions from senior citizens and will enable decision makers to prioritise services for senior citizens.Social implicationsAlthough senior citizens are the end users of ERFs, their needs are easily overlooked. This study calls attention to their needs from ERFs, and the results are likely to serve as references for stakeholders in building improved facilities.Originality/valueERFs have been provided in mainland China to cater to senior citizens’ needs since 2014. However, few studies have identified senior citizens’ requirements for provided services. The survey-based results of this work will serve as references for various stakeholders in making enhanced decisions.
Optimum arrangement of two-stage plug and concentrate recycling RO systems using thermodynamic and exergy analysis
Authors: Naeimi Abbas , Ahmadi Mohammad Hossein , Sadeghzadeh Milad , Kasaeian Alibakhsh 
Published: August 2019

Purpose
This paper aims to determine the optimum arrangement of a reverse osmosis system in two methods of plug and concentrate recycling.

Design/methodology/approach
To compare the optimum conditions of these two methods, a seawater reverse osmosis system was considered to produce fresh water at a rate of 4,000 m3/d for Mahyarkala city, located in north of Iran, for a period of 20 years. Using genetic algorithms and two-objective optimization method, the reverse osmosis system was designed.

Findings
The results showed that exergy efficiency in optimum condition for concentrate recycling and plug methods was 82.6 and 92.4 per cent, respectively. The optimizations results showed that concentrate recycling method, despite a 36 per cent reduction in the initial cost and a 2 per cent increase in maintenance expenses, provides 6 per cent higher recovery and 19.7 per cent less permeate concentration than two-stage plug method.

Originality/value
Optimization parameters include feed water pressure, the rate of water return from the brine for concentrate recycling system, type of SW membrane, feedwater flow rate and numbers of elements in each pressure vessel (PV). These parameters were also compared to each other in terms of recovery (R) and freshwater unit production cost. In addition, the exergy of all elements was analyzed by selecting the optimal mode of each system.
Malaysians’ awareness towards legal metrology and Weights and measures act, 1972
Authors: Nazim Ahsan Mohamed , AbuJarad Ismael , Sulaiman Mohamed , Hamzah Ibrahim bin 
Published: August 2019

Purpose The purpose of this study is to examine the level of awareness of the public about Weights and Measures Act, the awareness of Metrology Corporation Malaysia (MCM) services such as verification sticker and the awareness about ways to file a complaint by the public.

Design/methodology/approach A quantitative research methodology survey was used to collect data. The quantitative collected data were analysed to achieve the objectives of this study.

Findings The results of this study showed a low awareness level of the general public, especially non-stakeholders, knowledge, attitude and actual behaviour about the work of verification and re-verification and checking for verification sticker as well as ways of complaining if the instrument is not verified. In addition, the number of stakeholders working in the legal metrology area was high and Facebook was one of the most preferred media by the public to get awareness messages.

Research limitations/implications It is recommended for other researchers to enlarge the sample size and implement the study on more companies in the industry.

Practical implications The findings of this study revealed that public awareness, knowledge and intention have significant and positive relationship with actual behaviour of the public and that awareness, knowledge and actual behaviour among the non-stakeholder were low compared to the stakeholder. The results also enriched the stakeholders in legal metrology for improving public awareness, knowledge and actual behaviour toward the legal metrology and Wight and Measure Act, 1972.

Social implications This study shows that Facebook was one of the most preferred media by the public to get awareness messages. This reflects the important role that social media plays. This is useful to the companies because it helps them understand the preferences of public in the society. In addition, the results of this study are useful to the decision-makers in the industry, which is expected to impact the performance of such companies.

Originality/value This study is among the few studies conducted in the Malaysian context.
Synthesis and evaluation of amines/phenolics antioxidant for TMPTO base oil
Authors: Zhan Wen , Jia Dan , Jin YongLiang , Duan HaiTao , Li Jian , Liu Jun 
Published: August 2019

Purpose
The purpose of this paper is to synthesize amines/phenolic antioxidants by a new method and to characterize the influence of antioxidants on thermo-oxidative degradation in trimethylolpropane trioleate (TMPTO) base oil.

Design/methodology/approach
The molecule structures of antioxidants and lubricants were confirmed using Fourier transform infrared spectroscopy (FTIR). The oxidative stability of antioxidants and lubricants was evaluated by pressurized differential scanning calorimetry (PDSC).

Findings
These findings suggested that butyl-octyl-diphenylamine has obvious advantage on kinematic viscosity inhibition, and amine-phenol combination antioxidant has a slightly better suppression of total acid in TMPTO under thermal oxidation at 200°C for 96 h. The FTIR characterizations showed that all antioxidants could protect the basic structure of TMPTO in the early stage of thermal degradation.

Originality/value
Under the action of butyl-octyl-diphenylamine, the dehydrogenation of TMPTO is easily met with the alkenyl hydrogen = C–H bond in the unsaturated C = C. Meanwhile, as octadecyl 3-(3, 5-di-tert-butyl-4-hydroxyphenyl)propionate protects TMPTO, the unsaturated C = C bond in the base oil molecule easily breaks down during transition.
Exploring the scalability process of social innovation
Authors: Bolzan Larissa Medianeira , Bitencourt Claudia Cristina , Volkmer Martins Bibiana 
Published: August 2019

Purpose
Social innovation is a recent theme, and the practices related to this area are characterized by punctual actions and projects restricted by time and space that make it difficult to develop strategies that can be sustained in this field. Therefore, one point that deserves to be highlighted in studies on social innovation is a matter of scalability. This paper aims to deal with a bibliometry whose objective was to map the existing studies about scalability of social innovation carried out in the Capes and EBSCOHost portals.

Design/methodology/approach
This paper deals with a bibliometry. The topic researched in this bibliometry is scalability of social innovation. The databases chosen for this research were Portal Periódico Capes and EBSCOHost because they are the leading providers of search databases.

Findings
A total of 42 papers were considered, distributed between 2002 and 2017. The analysis criteria for the study were origin (composed by year, author, country of origin, periodical and impact factor), focus of the investigations, justification, method and main techniques of research, contributions and theoretical advances and challenges and paths.

Originality/value
Among the main results found, one of them is that scalability is a topic that began to be researched recently, so that the USA and Brazil lead the research. Most of the studies focused on the scalability process and justified the importance of studies on the subject as a way to explore the potential of expanding the social impacts of a social innovation. Several studies have emphasized the role of networks as being quite positive for the scalability process and have been concerned with identifying factors that contribute to the scalability process. The challenge that most stood out among the papers was the financial sustainability of a social innovation. At the end, a research agenda was proposed.
Exploring gender discursive struggles about social inclusion in an online gaming community
Authors: Naidoo Rennie , Coleman Kalley , Guyo Cordelia 
Published: August 2019

Purpose
The purpose of this paper is to adopt a critical relational dialectics framework to identify and explore gender discursive struggles about social inclusion observed in an online gaming community, in South Africa.

Design/methodology/approach
The paper uses a technique called contrapuntal analysis to identify and explore competing discourses in over 200 messages on gender struggles about social inclusion posted in the local community’s gamer discussion board, based on seven threads initiated by women gamer activists.

Findings
The findings show how four interrelated gender discursive struggles about social inclusion and social exclusion animated the meanings of online gamer relations: dominance vs equality, stereotyping vs diversity, competitiveness vs cooperativeness and privilege vs empowerment.

Practical implications
Game designers should reinforce more accurate and positive stereotypes to cater for the rapidly growing female gamer segment joining the online gaming market and to develop a less chauvinistic and more diversely representative online gaming community. Enlightened gamers should exercise greater solidarity in fighting for gender equality in online gaming communities.

Originality/value
The critical relational dialectics analysis adopted in this study offers a promising avenue to understand and critique the discursive struggles that arise when online gamers from the different gender groups relate. The findings highlight the unequal discursive power and privilege of many white male gamers when discussing social inclusion. Advancing our understanding of these discursive struggles creates the possibilities for improving social inclusion in online gaming communities.
Insurance regulations, risk and performance in Ghana
Authors: Kusi Baah Aye , Alhassan Abdul Latif , Ofori-Sasu Daniel , Sai Rockson 
Published: August 2019

Purpose This study aims to examine the hypothesis that the effect of insurer risks on profitability is conditional on regulation, using two main regulatory directives in the Ghanaian insurance market as a case study.

Design/methodology/approach This study used the robust ordinary least square and random effect techniques in a panel data of 30 insurers from 2009 to 2015 to test the research hypothesis.

Findings The results suggest that regulations on no credit premium and required capital have insignificant effects on profitability of insurers. On the contrary, this study documents evidence that both policies mitigate the effect of underwriting risk on profitability and suggests that regulations significantly mitigate the negative effect of underwriting risk to improve profitability.

Practical implications The finding suggests that policymakers and regulators must continue to initiate, design and model regulations such that they help tame risk to improve the performance of insurers in Ghana.

Originality/value This study provides first-time evidence on the role of regulations in controlling risks in a developing insurance market.