bluuebunny/crossref_metadata_2025_split huggingface dataset:
Camphor white oil induces tumor regression through cytotoxic T cell-dependent mechanisms
Authors: Moayedi Yalda , Greenberg Sophie A , Jenkins Blair A , Marshall Kara L , Dimitrov Lina V , Nelson Aislyn M , Owens David M , Lumpkin Ellen A 
Published: August 2018

ABSTRACTBioactive derivatives from the camphor laurel tree,Cinnamomum camphora, are posited to exhibit chemopreventive properties but the efficacy and mechanism of these natural products have not been established. We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. We next investigated underlying cellular and molecular mechanisms. In cultured keratinocytes, CWO stimulated calcium signaling, resulting in calcineurin-dependent activation of nuclear factor of activated T cells (NFAT).In vivo, CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. Finally, we identified chemical constituents of CWO that recapitulated effects of the admixture. Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden.SUMMARY BLURBEssential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma.
Directed exploration in the Iowa Gambling Task: model-free and model-based analyses in a large dataset of young and old healthy participants
Authors: Ligneul Romain 
Published: August 2018

AbstractThe Iowa Gambling Task (IGT) is one of the most common paradigms used to assess decision-making and executive functioning in neurological and psychiatric disorders. Several reinforcement-learning (RL) models were recently proposed to refine the qualitative and quantitative inferences that can be made about these processes based on IGT data. Yet, these models do not account for the complex exploratory patterns which characterize participants’ behavior in the task. Using a dataset of more than 500 subjects, we demonstrate the existence of such patterns and we describe a new computational architecture (Explore-Exploit) disentangling exploitation, random exploration and directed exploration in this large population of participants. The EE architecture provided a better fit to the choice data on multiple metrics. Parameter recovery and simulation analyses confirmed the superiority of the EE scheme over alternative schemes. Furthermore, using the EE model, we were able to replicate the reduction in directed exploration across lifespan, as previously reported in other paradigms. Finally, we provide a user-friendly toolbox enabling researchers to easily fit computational models on the IGT data, hence promoting reanalysis of the numerous datasets acquired in various populations of patients.
Blocking the Necroptosis Pathway Decreases RPE and Photoreceptor Damage Induced by NaIO3
Authors: Lin Haijiang , Roh Miin , Matsumoto Hidetaka , Atik Alp , Bouzika Peggy , Alhatem Albert , Miller Joan W. , Vavvas Demetrios G. 
Published: August 2018

AbstractPurposeSodium iodate (NaIO3) has been extensively used as a retinotoxin to induce RPE cell damage and degeneration of photoreceptorsin vitroandin vivo. RIP-Kinase dependent programmed necrosis is an important redundant cell death pathway involved in photoreceptor cell death. We wanted to determine whether these pathways are actively involved in RPE and photoreceptor cell death after NaIO3 insult.MethodsARPE-19 cells were exposed to different concentrations of NaIO3 in the presence or absence of various concentrations of a RIPK inhibitor (Nec-1) or a pan-caspase inhibitor (Z-VAD), individually or combined. Cell death was determined at different time points by MTT (Sigma-Aldrich), LDH (Promega) and TUNEL (Millipore) assay. C57BL/6 and RIP3−/-mice were treated with a peritoneal injection of NaIO3 and eyes were enucleated at day 3 or 7. TUNEL staining was used to evaluate photoreceptor cell death. Photoreceptor cell loss was evaluated by measuring the thickness of outer nuclear layer (ONL). Microglia in the ONL were quantified in a retinal whole mount with Iba-1 antibody. RPE degeneration was also assessed in a RPE whole mount, with ZO-1 antibody.ResultsNaIO3 resulted in significant cell death of ARPE-19 cells. Treatment with Nec-1 resulted in better protection than treatment with Z-VAD (P<0.01). A synergistic protective effect was observed when co-treating the cells with Nec-1 and Z-VAD. Nec-1 treatment also decreased the ARPE-19 mitochondrial damage caused by NaIO3.In vivoadministration of NaIO3 resulted in significant RPE and photoreceptor destruction with substantial inflammatory cell infiltration. RIP3 knockout animals displayed considerably less RPE and photoreceptor cell loss, as well as drastically less inflammation.ConclusionsProgrammed necrosis is an important cell death pathway mediating NaIO3 RPE and photoreceptor cell toxicity. Blocking the necroptosis pathway may serve as a novel therapeutic strategy for various RPE degenerative diseases.
Non-linear causality between exchange rates, inflation, interest rate differential and terms of trade in Tunisia
Authors: Charef Fahima , Ayachi Fethi 
Published: August 2018

PurposeThe purpose of this paper is to investigate the dynamic relationship between inflation, interest rate differential, the exchange trade and exchange rate parities, i.e. (USD/TND, EUR/TND and JPY/TND).Design/methodology/approachGiven the existing non-linear form between the different time series in this study, the empirical analysis is based on the using of non-parametric method such as the artificial neural networks. In order to detect the causality relationship between the variables, the authors use an NARX model.FindingsMixed results were found; there is a bidirectional relationship between inflation and exchange rate among others. Results also show that there is a strong correlation between the terms of trade and inflation, which says that trade openness increases the demand for imported goods and, therefore, causes more inflation for Tunisia.Originality/valueAfter these results, it is important for policymakers to know which factors influence exchange rate stability, especially in developing countries like Tunisia.
Quality changes of nugget prepared from fresh and smoked rainbow trout during chilled storage
Authors: Duman Muhsine , Karaton Kuzgun Nermin 
Published: August 2018

Purpose
The purpose of this paper is to produce fish nugget from fresh or smoked fish and to investigate the quality characteristics of fish nuggets during refrigerated storage.

Design/methodology/approach
The study was designed to evaluate the effect of fresh and smoked fish on the storage quality parameters of fish nuggets. The products were developed by incorporating optimum level of fresh and smoked separately and were vacuum packaged in low-density polyethylene pouches and assessed for various storage quality parameters under refrigerated (2±1°C) conditions for 27 days of storage. The products were evaluated for various chemical, microbiological and sensory parameters at regular interval of three day.

Findings
Nuggets from smoked fish had lower (p<0.05) moisture, higher fat and crude protein compared to fresh fish nuggets. Total volatile basic nitrogen for fresh nugget samples exceeded the limit value of 30 mg N/100 g fish muscle on the 24 days of storage. At the end of storage period, TBA values were 2.8 mg malonaldehyde/kg for fresh nugget samples and 2.1 mg malonaldehyde/kg for smoked nugget samples. Microbial counts were found to be significantly (p<0.05) higher in fresh nugget than in smoked nugget samples. Sensory quality scores of smoked nuggets were significantly higher, than fresh nugget. The shelf life of fish nugget was found to be 24 days for fresh nuggets and 27 days for smoked nugget samples according to sensory assessment results.

Originality/value
The paper has demonstrated that the smoked fish meat prouduce nuggets of better quality, as indicated by lower microbial counts and higher sensory attributes compared to fresh fish meat.
Motivation-based segmentation of local food in urban cities
Authors: Arsil Poppy , Li Elton , Bruwer Johan , Lyons Graham 
Published: August 2018

Purpose
The purpose of this paper is twofold: first, to investigate the motives of urban consumers when purchasing local food products using means-end chain (MEC) analysis and second, to introduce an alternative approach to segment the market based on consumers’ motivation using decision segmentation analysis (DSA).

Design/methodology/approach
DSA was used as advanced segmentation procedure of hierarchy value maps (HVMs) produced by MEC analysis.

Findings
The findings suggest that there are two main segments of local food consumers in urban Indonesia: value-for-money and health benefits. The value-for-money segment is dominant when making local food purchasing.

Research limitations/implications
This study sample is not representative of local food consumers in urban Indonesia as only three urban cities were interviewed.

Practical implications
An understanding of the motivation-based segmentation of local food in urban cities is a useful tool in order to reinforce and attract local food consumers to consume more locally grown food.

Originality/value
This study reveals the motivation-based segmentation of local food in urban cities in Indonesia.
Exploring the visual appeal of food guide graphics
Authors: Truman Emily 
Published: August 2018

Purpose
Food guides are graphic representations of food-based dietary guidelines that support national health policies and programming. They are visual aids simplifying complex nutritional messaging for the public. While pyramid and circle formats are the most common shapes in use worldwide, the dinner plate format is increasing in use due to its perceived effectiveness. However, research examining visual attributes of food guide graphics, and the dinner plate model specifically, is limited. The purpose of this paper is to systematically compare and analyse key visual attributes of plate food guide graphics (across multiple examples) to assess their potential for effective visual communication of nutrition messaging.

Design/methodology/approach
This study engages in a qualitative analysis of compositional elements of food guide graphics. Data collection and analysis are grounded in the methods of compositional interpretation, which includes a qualitative, descriptive approach to establishing a thematic survey of the data.

Findings
Unique visual attributes of the plate food guide (including image content, spatial organisation and expressive content) present challenges in the communication of key nutritional messaging regarding proportionality, moderation and overall usability.

Practical implications
A better understanding of the visual attributes of the plate food guide model will contribute to improved design and development of this key public health tool by researchers, educators and health practitioners. Additionally, the examination of visual attributes has implications for the study of food guide understanding and use.

Originality/value
This study highlights the need for critical visual skills in qualitative health research, and to address gaps in health education more broadly.
Studies on the potential application of various blends of essential oils as antioxidant and antimicrobial preservatives in emulsion based chicken sausages
Authors: Sharma Heena , Mendiratta Sanjod K. , Agrawal Ravi Kant , Talukder Suman , Kumar Sudheer 
Published: August 2018

PurposeOxidative rancidity is a major problem in chicken meat because of its higher content of polyunsaturated fatty acids. Besides this, microbial contamination is also one of the major problems of chicken meat which leads to deterioration in quality during storage. Therefore, the purpose of this paper is to investigate anti-microbial and anti-oxidant effects of various blends of essential oils (EOs) on the quality of emulsion-based (ready-to-eat) chicken sausages.Design/methodology/approachSausages were incorporated with optimum level of four different blends of EOs containing six different EOs (Clove oil, Holybasil oil, Thyme oil, Cassia oil, Ajowan oil and Beetel oil), namely, Blend-1 (0.25 per cent), Blend-2 (0.25 per cent), Blend-3 (0.25 per cent) and Blend-4 (0.125 per cent); vacuum packaged and stored at −18±1°C for 60 days. Duplicate samples were taken for each parameter, and three trials were conducted for each experiment, total being six observations (n=6) for consistency of the results.FindingsSignificant decrease (p<0.05) in pH of control products was observed at each interval of storage period; however, in case of treatment products, significant decrease (p<0.05) was noticed from day 30 onwards. Blend-2 was observed with significantly lower (p<0.05) thio-barbituric acid reacting substances followed by Blend-1. Significantly lower (p<0.05) total phenolics content was observed in Blend-4 products as compared to other treatments. Regarding DPPH activity, control products showed significant decrease (p<0.05); however, in case of treatment products, DPPH activity showed significant (p<0.05) decrease after day 15 of storage. Microbial count increased with progressive storage period; however, the counts were well below the permissible limit of frozen meat products. All the blend incorporated products received very good sensory scores in consistent manner.Practical implicationsThe work under this study would be very useful for the meat processing industries dealing with the perishable meat products. Use of natural anti-oxidants will also restore faith towards the consumers who are becoming more health conscious day by day.Originality/valueThe research work is original.
Halal logistics service quality: conceptual model and empirical evidence
Authors: Zailani Suhaiza , Jafarzadeh Shima , Iranmanesh Mohammad , Nikbin Davoud , Selim Nur Izatul Irani 
Published: August 2018

PurposeThe purpose of this paper is to devise and test a model of halal logistic service quality.Design/methodology/approachTo develop the halal logistics service quality model, the relevant literature was reviewed and a qualitative study was carried out on halal logistics service providers and their customers. A survey of 253 halal food and beverage firms in Malaysia was conducted, and based on the results, a model was developed and tested empirically.FindingsBased on the literature review, interviews, pretest and empirical study, a valid and reliable measurement instrument for halal logistics service quality was developed.Practical implicationsThe findings can help managers of halal logistics service providers to understand the criteria that halal food and beverage firms are considered to judge the quality of halal logistics services.Originality/valueThis study makes a valuable contribution by proposing a halal logistics service quality model.
Influence of sensory attributes on consumers’ emotions and hedonic liking of chocolate
Authors: Schouteten Joachim J. , De Pelsmaeker Sara , Juvinal Joel , Lagast Sofie , Dewettinck Koen , Gellynck Xavier 
Published: August 2018

Purpose
The purpose of this paper is to examine the influence of sensory attributes of milk chocolate on consumers’ emotions and their hedonic ratings using three commercial brands of milk chocolate.

Design/methodology/approach
Quantitative descriptive analysis by a trained panel (n=8) was performed to obtain the sensory evaluation of the samples. A group of 127 consumers evaluated the samples to indicate their hedonic ratings (nine-point hedonic scale) and emotions (EsSense Profile®).

Findings
The sensory profiles for the three chocolate types showed clear differences. EsSense Profile® methodology revealed that each type of chocolate had a distinct emotional profile. The premium brand was associated with the highest number of positive emotions, whereas the traditional brand was associated with most of the negative emotions (“bored”, “disgusted” and “worried”). The drivers of liking were mainly positive and unclassified emotions. Also, gender differences in emotional profiling were found.

Practical implications
This study illustrates that sensory and emotional measurements can contribute to a better understanding of consumers’ hedonic liking. Moreover, gender differences found in emotional profiling should raise awareness that gender may lead to different emotional profiling. These gender differences are of interest to food companies, for instance, for food product development or marketing purposes.

Originality/value
This study further contributes to the growing literature on emotions. By combining sensory evaluation by a trained panel and emotional profiling by consumers, this paper explores how combining these measurements can contribute to a better understanding of the drivers of liking for milk chocolate.
Classification of pork quality by hierarchical cluster analysis
Authors: Torres Filho Robledo de Almeida , Silva Vanelle Maria da , Rodrigues Lorena Mendes , Fontes Paulo Rogério , Ramos Alcinéia de Lemos Souza , Ramos Eduardo Mendes 
Published: August 2018

Purpose
The purpose of this paper is to evaluate the classification ability of pork quality by cluster analysis in relation to reference criteria proposed in the literature. Verify if clusters were theoretically significant with major pork quality categories. Verify if classificatory parameter values of quality attributes determined “a posteriori” may be used for following categorization.

Design/methodology/approach
In total, 60 pork loins were classified into pale, soft and exudative, reddish-pink, soft and exudative, RFN and dark, firm and dry by reference criteria and hierarchical cluster analyses were performed to identify groups of samples with different attributes, based on only pH45min and on pHu, L* and drip loss.

Findings
Cluster analysis divided total samples into different (p<0.05) smaller groups. Two groups were formed based on only pH45min and five groups were formed based on pHu, L* and drip loss. By these five groups, L* of 44 and 52 distinguished between dark, reddish-pink and pale meat colors and drip loss of 2 and 6 percent distinguished between dry, non-exudative and exudative meats. Cluster analyses identify pork groups with different attributes and the proposed parameters can be used to distinguish between groups theoretically similar to major pork quality categories.

Originality/value
To decide the best destination to pork carcass and to reduce economic losses, the correctly classify of the pork quality is decisive. This study proves that cluster analysis is able to classify pork into groups with significantly different quality attributes, which are significant with major pork quality categories, without unclassified samples.
Combining means-end chain analysis and goal-priming to analyze Tanzanian farmers’ motivations to invest in quality seed of new potato varieties
Authors: Okello Julius J. , Lagerkvist C.J. , Kakuhenzire Rogers , Parker Monica , Schulte-Geldermann Elmar 
Published: August 2018

Purpose
Potato is a major food staple in Africa, but its production is constrained by poor quality of seed. A recent private–public partnership in Tanzania resulted in introduction of new higher yielding varieties. The purpose of this paper is to examine smallholder farmers’ motivations to invest in the purchase of quality seed of new potato varieties, and if the motivational structure differs by gender.

Design/methodology/approach
The paper used means-end chain (MEC) theory combined with goal priming, and laddering interviews on randomly sampled participants (n=45) of an experimental auction conducted among smallholder farmers in Tanzania. The auction was designed to goal-prime respondents on benefits of quality seed. The mental constructs obtained were grouped into attributes, consequences and values, and MECAnalyst software used to generate hierarchical value maps.

Findings
Farmers invest in quality seed of a new variety to increase yields, hence income, and also to pursue personal life goals (values) or meet psychosocial needs. The structure of mental constructs associated with the decision to invest in quality seed of a new variety differ by gender.

Research limitations/implications
The study focused on only two new varieties, hence not robust to all new potato varieties. Results need to be tested under different socioeconomic contexts. Furthermore, the MEC approach does not allow for control of other variables that likely influence farmer adoption decision-making process. Future studies should be designed to tackle these limitations.

Practical implications
Investment in quality seed of new variety is driven by monetary goals and psychosocial factors, and some of these factors differ between male and female farmers.

Originality/value
This is the first study to explore drivers of farmers’ decision to use quality seed of a new variety using MEC analysis, and role psychosocial factors play.
Consumers’ risk perception, information seeking, and intention to purchase genetically modified food
Authors: Zhu Weiwei , Yao Nengzhi (Chris) , Ma Ben , Wang Fangbin 
Published: August 2018

Purpose
The purpose of this paper is to explore consumers’ intention to purchase genetically modified (GM) food from the perspective of risk information.

Design/methodology/approach
A conceptual model was proposed in which intention to purchase GM food is stimulated by the combination and complex effects of knowledge, risk perception, information need, information seeking and attitude. A face-to-face questionnaire survey was conducted in Jinan, Shandong Province. A total of 757 valid samples (55.6 percent of women vs men) were involved to conduct structural equation model analysis.

Findings
Results demonstrated that attitude is the most important predictor of intention to purchase GM food. Attitude, in turn, is predicted by risk perception and information seeking. Risk perception is a significant determinant of information need and information seeking. Moreover, information need influences information seeking. Finally, knowledge plays a critical role in risk perception and intention. Overall, the explained variance of the model is 66 percent.

Originality/value
The study provides new insights explaining intention to purchase GM food by constructing a conceptual model from the perspective of risk information. In this model, knowledge, risk perception, information need and information seeking are all based on information related to GM food, resulting in attitude and intention to purchase.