bluuebunny/crossref_metadata_2025_split huggingface dataset:
TO STUDY THE SEX SPECIFIC DISTRIBUTION OF VARIOUS DERMATOSES IN THE GERIATRIC POPULATION
Authors: Rao Pankaj , Kumar Vineet , Chouhan Chandraprakash , S Rekha 
Published: April 2019

Background: In aging, a decline in the regular functions of skin is observed, including cell replacement capacity, barrier function, chemical clearance capacity, sensory perception, mechanical protection, wound healing, immune responsiveness, thermoregulation, sweat production, sebum production, vitamin D production, and capacity to repair DNA. As a result, some inevitable changes, such as roughness, wrinkling, and laxity of the skin, and atypical presentations of dermatologic diseases are observed in elderly patients.
Methods: Five hundred consecutive patients more than 60 years of age attending the outpatient clinic or admitted as inpatients in the Department of Dermatology, STD and Leprosy at MDM Hospital, Jodhpur were studied.
Results: Of the total of 500 participants in our study, 263 (52.6%) were males and the rest were females. Most common dermatosis noted in the target population was benign tumors, present in 322 patients (64.4%). Second most common disease group affecting the elderly was the infections and infestations group, being present in 215 patients (43%). Infections were present in 195 patients (39%) while infestations were present in 24 patients (4.8%). Four patients presented with infection along with infestation.
Conclusion: Males outnumbered females with male to female ratio 1.11:1. The distribution and frequency of various dermatoses varies significantly from country to country and region to region
Keywords: Gender, Ageing, Dermatoses, Pruritus, Senile.
FASTING LIPID PROFILE AND DISEASE SEVERITY IN SEPSIS PATIENTS
Authors: Sood Pramod , Kaur Manpreet 
Published: April 2019

Background: During an infection and inflammation many cytokines are released. This produces many changes in plasma lipids and lipoprotein concentration.
Methods: This was a prospective observational study. Patients with age greater than 18 years and satisfying the criteria for sepsis according to International guidelines for management of severe sepsis and septic shock 2016 were included.
Results: The study population comprised 16 males and 14 females with mean age of 57.2 ± 7.21 years. Both groups were comparable. Cholesterol, HDL and LDL level difference in septic and control was stastically significant.
Conclusion: In ICU setting, measurement of cholesterol values has been shown to improve risk prediction, and inclusion of lipid values in clinical risk assessment scores of critically ill patients has been advocated.
Keywords: Lipid profile, Sepsis, Cholesterol.
Ismayıl Hakkı Baltacıoğlu’nun Özgün Eğitim Sistemi ve Bu Sistemin Zamanın Çağdaş Eğitim Yaklaşımları ile Karşılaştırılması
Authors: DEMİR Okay , DURUHAN Kemal 
Published: April 2019

Ülkemizde sırasıyla Mutlakiyet, Meşrutiyet, Milli Mücadele, Cumhuriyet ve Çok Partili Hayat olmak üzere beş döneme şahitlik eden, aynı zamanda Avrupa’nın pek çok şehrinde eğitim amaçlı gözlemler yapan ve dönemin bir çok batılı ünlü eğitimcisi ile görüşmelerde bulunan Ismayıl Hakkı Baltacıoğlu kuşkusuz Türk eğitim tarihinde çok önemli bir yeri bulunan
bir eğitim filozofudur. Bu çalışmanın amacı, Türk pedagojisine çok önemli katkıları olan Ismayıl Hakkı Baltacıoğlu’nun eğitim yaklaşımını genel hatlarıyla ortaya koymak ve bu yaklaşımın diğer çağdaş eğitim yaklaşımları ile arasındaki farklılıklara değinmektir. Bu amaca uygun
olarak Baltacıoğlu’nun eğitim alanında ortaya koymuş olduğu eserler, onun eğitim anlayışını yansıtan teorik çalışmalar ve karşılaştırılmak istenen çağdaş eğitim kuramları incelenerek bir derleme
çalışması ortaya konulmuştur. Baltacıoğlu’nun İçtimai Mektep sisteminin batılı çağdaş eğitim anlayışlarına kıyasla bir çok farklılıklara sahip olduğu ve ilkelerinin bütünü göz önüne alındığında özgün bir eğitim sisteminin olduğu sonucuna ulaşılmıştır.
Odbudowa gmachu doświadczalnego Szkoły Głównej Handlowej w Warszawie po II wojnie światowej
Authors: Jarosz-Nojszewska Anna 
Published: April 2019

In 2008 the Campus of the Warsaw School of Economics (SGH) was entered into the register of monuments. The Research Pavilion, so called Building A, is the oldest of the campus buildings. It was constructed between WWI and WWII according to the design of Jan Koszczyc-Witkiewicz, one of the most renowned contemporary architects. During WWII, immediately after the end of the Warsaw Uprising, the Germans burnt down this building despite the signed capitulation agreement guaranteeing the protection of Polish national heritage monuments. The building accommodated at that time the archives of Polish pre-war state institutions, which were completely destroyed. The building was reconstructed after the WWII as a results of the efforts of the university authorities and personal involvement of Professor Stanisław Skrzywan. The paper presents the process of reconstruction of the listed building based on archive sources - the Archives of the capital city of Warsaw (the archives of the Capital Reconstruction Bureau)and SGH Archives (the minutes from meetings of the SGH Senate), the memoires and contemporary press
Kilka uwag o warunkach pokoju. Myśl o człowieczeństwie
Authors: Oniszczuk Jerzy 
Published: April 2019

Although the terrorist-war experience of the years since 2001 lead to conclusions that the last years negatively affected world peace, the Paris terror attacks of 2015 transformed peace into bad peace. Global terrorism is a form of expression of some form of evil, but not its explanation. The first victim of terror, as of war, is truth. The absolute power is in the hand of all justifying lie which is also influencing the absurd "shame of condemnation" of war in itself. That lie also permits the democracies to ignore the reflections on war. What is the role of the people who try to approach the world of violence with reflection? Intellectuals are expected to provide answers; the main function of thinking is bringing up the stories with the aim, according to the writer Terziani, of sharing wisdom and re-establishing the conscious.
Oczekiwanie zmiany nastawienia credit ratings banków a kursy akcji przy uwzględnieniu poziomu rozwoju gospodarczego kraju
Authors: Chodnicka-Jaworska Patrycja 
Published: April 2019

The aim of the paper is verification of the following hypothesis the share prices of banks have stronger reaction to bank credit rating announcements changes for a downgrade, both in developed and developing economies. The analysis(event study method) has been based on data from Thomson Reuters for the years 1980-2015 for 24 countries. Outlooks and watch lists proposed by all credit rating agencies have been used as an independent variable. Daily differences between the logarithmized rates of return of banks' shares have been used as dependent variable.
Zadłużenie gospodarstw domowych a dynamika wydatków konsumpcyjnych w krajach OECD po wybuchu kryzysu finansowego
Authors: Bolibok Piotr 
Published: April 2019

The paper aims at empirical evaluation of the impact of household debt on the dynamics of consumption spending since the beginning of the global financial crisis. The research employed linear regression analysis of the rate of growth of household spending against the rate of growth of disposable income, the level of indebtedness and long-term interest rates in the OECD member states between 2008-2014. The results obtained indicate that household indebtedness was one of the factors influencing the dynamics of consumption demand and thus the processes of economic growth in the OECD states after the beginning of the global financial crisis. Variations in the relation of total debt to net disposable income and in the level of long-term interest rates were both negatively related to the changes in consumption spending. This impact turned out to be markedly stronger when total household debt of a given country was exceeding 85% of GDP, which is consistent with the results of previous investigations on the in&uence of the indebtedness of household sector on the dynamics of economic growth
Społeczne i ekonomiczne przesłanki sycylijskiego separatyzmu od zjednoczenia Włoch do połowy XX wieku. Mafia a kwestia niepodległości Sycylii ​
Authors: Janek Jolanta 
Published: April 2019

The article presents broad historical context, including socio-economic factors, of the rise and periodic resurgence of the movement for Sicilian independence following the unification of Italy in the 1860s. Furthermore, the involvement of Cosa Nostra in the movement for Sicilian independence in the period beginning with the Allied invasion of Sicily during the Second World War is analysed.
Rola banków i sektora FinTech w świetle implementacji dyrektywy PSD2 ​
Authors: Grzywacz Jacek , Jagodzińska-Komar Ewa 
Published: April 2019

The aim of the article is to define the prospects for the development of cooperation between the banking sector and FinTech in the context of the implementation of the PSD2 directive. First, attention was drawn to the changing role of banks that have already taken actions to use the opportunities related to the implementation of this EU regulation of the European payments market. It has been pointed out that the opening of the banking system will result in close cooperation with the FinTech sector, so-called API economics, and this will affect the emergence of new business models. Next, new solutions developed in the PSD2 Directive were presented, with reference to new regulatory technical standards between the banking sector and third parties. The last issue raised in the article concerns cooperation between banks and the FinTech sector. Financial institutions should use innovative solutions offered by fintechs and thanks to that they will increase operational efficiency and create products and services better suited to clients' needs. In the next years, it will be possible to observe how the financial services market will change and which entities will play a significant role in it.
DAMPAK PENGEMBANGAN DESA MAS SEBAGAI DESA WISATA DI KECAMATAN UBUD, KABUPATEN GIANYAR
Authors: Sukmawati Ni Made Rai , Solihin Solihin , Susyarini Ni Putu Wiwiek Ary 
Published: April 2019

Desa Mas, Ubud sudah terkenal ke manca negara sebagai desa penghasil seni kerajinan patung. Seiring dengan berkembangnya kepariwisataan dan juga karena adanya tingkat kunjungan wisata yang datang ke Indonesia setiap tahunnya mengalami peningkatan rata-rata dari tahun 2012 -2016 sebesar 8.15%. dan tahun 2017 terjadi penurunan karena adana erupsi Gunung Agung. Melihat peluang ini muncul keinginan masyarakat Desa Mas untuk mengembangkan daerahnya selain sebagai pusat seni pahat tetapi juga menjadi daerah tujuan wisata dengan menggali potensi budaya yang ada di desa tersebut.Tahun 2015 Bali dipusatkan oleh pemerintah sebagai salah satu pintu gerbang masuknya wisatawan ke Indonesia selain Jakarta dan Batham. Melihat situasi ini maka diharapkan Bali mampu meningkatkan daya saingnya untuk menarik wisatawan datang ke Bali baik itu wisatawan lokal, nasional, maupun internasional, sehingga Desa-desa yang sudah berbenah menjadi Desa Wisata seperti Desa Mas bisa mendapatkan manfaat dari kegiatan pariwisata tersebut. Kebijakan yang dibuat oleh Pemerintah diharapkan memihak pada masyarakat lokal dengan harapan program-program yang dibuat oleh Pemerintah dapat menyentuh masyarakat sehingga masyarakat merasa ikut terlibat dalam kegiatan itu. Dengan adanya program Desa Wisata diharapkan mampu menumbuhkan kreatifitas masyarakat lokal dan mempertahankan warisan budaya yang dimilikinya sehingga pengembangan pariwisata yang berkelanjutan dapat dilestarikan. Desa Mas sebagai salah satu Desa Wisata yang ada di Bali memiliki potensi yang cukup memadai sepertai sarana dan prasarana dan juga desa ini berada di jalur yang strategis antara Ubud dan jalur menuju destinasi Tampak Siring dan Kintamani, sehingga Desa Mas harus dilewati. Ubud sebagai salah satu destinasi wisata yang sudah terkenal ke manca negara. Desa Mas sebagai Desa Wisata dampak ditimbulkan berupa sosial budaya dan dampak ekonomi namun dampak tersebut khususnya dampak ekonomi dirasakan oleh masyarakat belum merata karena masih minimnya jumlah wisatawan yang tinggal dan memakai fasilitas yang disiapkan oleh penduduk setempat.
Threshold Value Determination Using Machine Learning Algorithms for Ba Interference with Eu in Coal and Coal Combustion Products by ICP-MS
Authors: Xu Na , Li Qing 
Published: April 2019

Ba-based ion interference with Eu in coal and coal combustion products during quadrupole-based inductively coupled plasma mass spectrometry procedures is problematic. Thus, this paper proposes machine-learning-based prediction models for determination of the threshold value of Ba interference with Eu, which can be used to predict such interference in coal. The models are trained for Eu, Ba, Ba/Eu, and Ba interference with Eu. Under different user-defined parameters, different prediction models based on the corresponding model tree can be applied to Ba interference with Eu. We experimentally show the effectiveness of these different prediction models and find that, when the Ba/Eu value is less than 2950, the Ba-Eu interference prediction model is y = − 0.18419411 + 0.00050737 × x , 0 < x < 2950 . Further, when the Ba/Eu value is between 2950 and 189,523, the Ba-Eu interference prediction model of y = 0.293982186 + 0.00000181729975 × x , 2950 < x < 189 , 523 yields the best result. Based on the optimal model, a threshold value of 363 is proposed; i.e., when the Ba/Eu value is less than 363, Ba interference with Eu can be neglected during Eu data interpretation. Comparison of this threshold value with a value proposed in earlier works reveals that the proposed prediction model better determines the threshold value for Ba interference with Eu.
Розвиток витривалості юних спортсменів 12-13 років у велотуризмі на початковому етапі підготовки
Authors: Kozina Zh. L. , Koval К.А. , Vasilyev Yu.K. 
Published: April 2019

Мета дослідження – розробити і обгрунтувати комплексну методику розвитку витривалості школярів середніх класів засобами велотуризму. Матеріал і методи. В даному дослідженні приймали участь велотуристи 12-13 років Липкуватіської загально–освітньої школи l-lll ступенів (9 спортсменів склали експериментальну групу, 9 – контрольну). Для визначення функціональних можливостей школярів середніх класів застосовувались наступні проби і тести: Гарвардський степ-тест, проба Штанге, проба Генчі, проба Серкіна. Розроблено методику розвитку витривалості, яка передбачає застосовування комплексу засобів велотуризму. Комплекс складається з 2-х частин: комплексна дистанція «тріал і фігурне водіння велосипеда» і велопохід. Тріал являє собою дистанцію довжиною 100-200 м. з природними та штучними перешкодами (крутий схил; яр; піщані; заболочені та інші важкопрохідні дільниці; струмки; калюжі; стовбури дерев, що лежать, тощо) по вузькому коридору (до 1,5м), утвореному природними і штучними обмеженнями (стрічки між деревами або стійками тощо). Фігурне водіння велосипеда передбачає застосування наступних перешкод: «Щілина», «Змійка між стійками», «Коридор», «Колія», «Коло», «Вісімка», «Ворота», «Кільце», «Перенесення предмету», «Зигзаг», «Гойдалка», «Змійка між фішками», «Стоп-лінія. Фініш». Особливістю походу є те, що окрем розвитку витривалості, він вирішував завдання виховного та освтнього характеру шляхом ознайомлення з цікавими місцями Слобожанщини, зустрічами з цікавими людьми тощо. Результати. Показано, що авторська методика комплексного розвитку витривалості, що поєднує засоби фігурного вождіння та велопоходу, є більш ефективною у порівнянні з традиційною методикою розвитку витривалості школярів середніх класів, яка містить виключно подолання дистанцій; виявлено, що застосування комплексної методики розвитку витривалості школярів середніх класів сприяє підвищенню часу затримки дихання за пробами Штанге, Генчі, Серкіна, а також зменшенню ЧСС спокою, ЧСС після стандартного навантаження та підвищенню якості відновлення працездатності. Висновок. Розроблена методика може застосовуватись в підготовці юних велотуристів.
Індивідуальна факторна структура підготовленості кваліфікованих волейболісток
Authors: Kozina Zh.L. , Khrapov S.B. , Yevstratov S. , Kolomiets N.A. , Hryshchenko S.V. , Minenok A.O. , Nosko Iu.M. 
Published: April 2019

Мета дослідження полягала у розробці індивідуальних факторних моделей фізичної підготовленості волейболісток високого класу різного ігрового амплуа. Матеріал і методи. У дослідженні взяли участь 12 гравців жіночої команди “Харків’янка” м. Харкова Волейболістки тестувались за 10 показниками педагогічними педагогічного тестування: Біг до 4-х точок; Біг для визначення швидкості переміщення по волейбольній площадці на відстань 30 м (9-3-6-3-9 м); Стрибок у висоту з місця; Стрибок у висоту з розбігу; Метання набивного м'яча з вихідного положення сидячі; Метання набивного м'яча з вихідного положення лежачі; Підйоми тулуба із положення лежачи на спині за 20 с (кількість разів); Підйоми тулуба із положення лежачи на животі за 20 с (кількість разів); Згинання-розгинання рук в упорі лежачі за 20 с (кількість разів); Стрибок у довжину з місця. Отримані дані математично оброблялися із застосуванням методів факторного аналізу, на основі чого будувалися індивідуальні факторні моделі гравців. Результати. На підставі факторного аналізу була визначена структура підготовленості кваліфікованих волейболісток, у якій виявилося чотири виражених фактори: швидкісно-силова підготовленість, відносна сила, спеціальна витривалість, швидкісна витривалість. Визначено модель належності гравців до амплуа згідно до визначеної факторної структури: у нападників першого темпу на перший план виступають такі фактори, як швидкісно-силова підготовленість та відносна сила, у нападників другого темпу – швидкісно-силова підготовленість та швидкісна витривалість, у зв'язок – швидкісна витривалість та спеціальна витривалість, у ліберо – відносна сила та спеціальна витривалість. Висновок. Користуючись розробленою схемою, індивідуальними факторними моделями гравців та розробленою шкалою оцінок показників тестування, можна визначити індивідуальні потенціальні можливості різних гравців до гри в різних амплуа.
Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer
Authors: Leko Vid , McDuffie Lucas A. , Zheng Zhili , Gartner Jared J. , Prickett Todd D. , Apolo Andrea B. , Agarwal Piyush K. , Rosenberg Steven A. , Lu Yong-Chen 
Published: April 2019

Abstract
Immune checkpoint inhibitors are effective in treating a variety of malignancies, including metastatic bladder cancer. A generally accepted hypothesis suggests that immune checkpoint inhibitors induce tumor regressions by reactivating a population of endogenous tumor-infiltrating lymphocytes (TILs) that recognize cancer neoantigens. Although previous studies have identified neoantigen-reactive TILs from several types of cancer, no study to date has shown whether neoantigen-reactive TILs can be found in bladder tumors. To address this, we generated TIL cultures from patients with primary bladder cancer and tested their ability to recognize tumor-specific mutations. We found that CD4+ TILs from one patient recognized mutated C-terminal binding protein 1 in an MHC class II–restricted manner. This finding suggests that neoantigen-reactive TILs reside in bladder cancer, which may help explain the effectiveness of immune checkpoint blockade in this disease and also provides a rationale for the future use of adoptive T cell therapy targeting neoantigens in bladder cancer.
FAMILIAL MEDITERRANEAN FEVER: ASSESSING THE OVERALL CLINICAL IMPACT AND FORMULATING TREATMENT PLANS
Authors: Rigante Donato , Manna Raffaele 
Published: April 2019

Recurrent self-limited attacks of fever and short-lived inflammation in the serosal membranes, joints and skin are the leading features of familial Mediterranean fever (FMF), the most common autoinflammatory disorder in the world, transmitted as autosomal recessive trait caused by MEFV gene mutations. Their consequence is an abnormal function of pyrin, a natural repressor of inflammation, apoptosis and release of cytokines. FMF-related mutant pyrins are hypophosphorylated following RhoA GTPases’ impaired activity and show a propensity to relapsing uncontrolled systemic inflammation with inappropriate response to inflammatory stimuli and leukocyte spread to serosal membranes, joints or skin. Typical FMF phenotype 1 consists of brief episodes of inflammation and serositis, synovitis, and/or erysipelas-like eruption, whereas phenotype 2 is defined by reactive amyloid-associated (AA) amyloidosis, which is the most ominous complication of FMF, in otherwise asymptomatic individuals. Furthermore, FMF phenotype 3 is referred to the presence of two MEFV mutations with neither clinical signs of FMF, nor AA amyloidosis. The influence of epigenetic and/or environmental factors can contribute to the variable penetrance and phenotypic heterogeneity of FMF. Colchicine, a tricyclic alkaloid with anti-microtubule and anti-inflammatory properties, is the bedrock of FMF management: daily administration of colchicine prevents the recurrence of FMF attacks and the development of secondary AA amyloidosis. Many recent studies have also shown that anti-interleukin-1 treatment is actually the best therapeutic option for FMF patients nonresponsive or intolerant to colchicine. This review aims to catch readers’ attention on the clinical diversity of phenotypes, differential diagnosis, and management of patients with FMF.
Some aspects of the deep abyssal overflow between the middle and southern basins of the Caspian Sea
Authors: Babagoli Matikolaei Javad , Aliakbari Bidokhti Abbasali , Shiea Maryam 
Published: April 2019

Abstract. The present study investigates the deep gravity current between the
middle and southern Caspian Sea basins caused by the density difference of
deep waters. Oceanographic data, a numerical model and a dynamic model are
used to consider the structure of this Caspian Sea abyssal overflow. The CTD
data are obtained from UNESCO, and the three-dimensional COHERENS ocean model
results are used to study the abyssal currents in the southern basin of the
Caspian Sea. The deep overflow is driven by the density difference, which is mainly owing to the
temperature difference, between the middle and southern basins, especially in
winter. Due to cold weather in the northern basin, water sinks at high
latitudes and after filling the middle basin it overflows into the southern
basin. As the current passes through the Absheron Strait (or sill), we use
the analytic model of Falcini and Salusti (2015) for the overflow gravity
current to estimate the changes in the vorticity and potential vorticity of the
flow over the Absheron sill; the effects of entrainment and friction are also
considered. Due to the importance of the overflow with respect to deep water
ventilation, a simple dynamical model of the boundary currents based on the
shape of the Absheron Strait is used to estimate typical mass transport and
flushing time; the flushing time is found to be about 15 to 20 years for the southern
basin of the Caspian Sea. This timescale is important for the region's
ecosystem and with respect to the impacts of pollution due to oil exploration.
In addition, by reviewing the drilled oil and gas wells in the Caspian Sea, the
results show that the deep overflow moves over some of these wells. Thus, the
deep flow could be an important factor influencing oil pollution in the deeper region of
the southern Caspian Sea.