bluuebunny/crossref_metadata_2025_split huggingface dataset:
MORPHOLOGICAL CHARACTERISTICS AND VISUAL ACUITY OF HIGHLY MYOPIC EYES WITH DIFFERENT SEVERITIES OF MYOPIC MACULOPATHY
Authors: Zhao Xiujuan , Ding Xiaoyan , Lyu Cancan , Li Songshan , Liu Bingqian , Li Tao , Sun Limei , Zhang Aiyuan , Lu Jinge , Liang Xiaoling , Jin Chenjin , Lu Lin 
Published: December 2018

Purpose:
To investigate the morphological feature, visual acuity, and prevalence of macular complications in highly myopic eyes with different categories of myopic maculopathy (MM) according to the META-PM classification system.

Methods:
The clinical records of 1,132 consecutive patients (1,841 eyes) with high myopia (refractive error ≤ −6D and axial length ≥26.5 mm), who visited the High Myopia Clinic at the Zhongshan Ophthalmic Center from January 2014 to July 2017, were reviewed. Fundus photograph, optical coherence tomography, axial length, refractive error, and best-corrected visual acuity were measured in each patient. Myopic maculopathy was graded from fundus photographs according to the META-PM classification, including tessellated fundus (C1), diffuse chorioretinal atrophy (C2), patchy atrophy (C3), and macular atrophy (C4). Other macular complications, including foveoschisis, extrafoveal schisis, full-thickness macular hole, epiretinal membrane, lacquer cracks, Fuchs spot, choroidal neovascularization, macular hemorrhage, and dome-shaped macula, were also investigated.

Results:
Among the 1,841 eyes, 58 (3.15%) had no MM (C0), 779 (42.31%) had tessellated fundus only (C1), 524 (28.46%) had diffuse chorioretinal atrophy (C2), 352 (19.12%) had patchy chorioretinal atrophy (C3), and 128 (6.95%) had macular atrophy (C4). Age increased and best-corrected visual acuity became worse with the severity of MM (P < 0.01). Axial length was significantly longer with the severity of MM from C0 to C3 (P < 0.01), and spherical equivalent was greater with the severity of MM from C0 to C3 (P < 0.01) but was not different between C3 and C4 (P > 0.05). Subfoveal and parafoveal choroidal thicknesses were significantly thinner from C0 to C3 (P < 0.01). However, no significant difference was found between C3 and C4 in parafoveal choroidal thickness (P > 0.05). The complications were different among C0 to C4 correlated with MM (P < 0.01). The complications of foveoschisis, choroidal neovascularization, hemorrhage, lacquer cracks, Fuchs spot, dome-shaped macula, and epiretinal membrane were different between C1 and C2 (P < 0.01), but none of the complications were different between C3 and C4 (P > 0.05) except Fuchs spot (P = 0.009).

Conclusion:
The morphological and functional characteristics in eyes with high myopia were positively correlated with the severity of C0 to C3 MM. However, no morphological difference was found between C3 and C4. The absence of the progressive relationship between C3 and C4 might be determined.
Descemet Membrane Endothelial Keratoplasty After Failed Penetrating Keratoplasty
Authors: Pierné Kévin , Panthier Christophe , Courtin Romain , Mazharian Adrien , Souedan Vael , Gatinel Damien , Saad Alain 
Published: December 2018

Purpose:
To demonstrate the feasibility of Descemet membrane endothelial keratoplasty (DMEK) performed after previous penetrating keratoplasty (PK) failure and to describe primary outcomes.

Methods:
Twenty-eight eyes of 28 patients who underwent DMEK after primary PK failure between January 2013 and November 2017 were included in this single-center retrospective study. Best spectacle-corrected visual acuity, endothelial cell density, and the recipient's central corneal thickness were recorded preoperatively and at 1, 3, and 6 months after surgery.

Results:
The main indications for primary PK were keratoconus (32%), Fuchs dystrophy (18%), and pseudophakic bullous keratopathy (14%). After a 6-month follow-up, best spectacle-corrected visual acuity was significantly improved in 26 patients (93%) with a mean gain of +0.59 ± 0.47 LogMAR (P < 0.0004). Mean pachymetry reduction was 110 ± 108 μm (P < 0.00003) at 6 months. Mean endothelial cell density was 2016 ± 288 cells/mm2 (P < 0.006), (24% decrease compared with preoperative values). Graft detachment (>1/3) was observed in 14 cases (50%) and rebubbling was needed (100% effective) during the first 2 weeks after surgery. Elevated intraocular pressure was reported in 5 cases. No early graft rejections were reported.

Conclusions:
In case of previous PK failure, DMEK is an alternative treatment to re-PK. A longer follow-up to ensure the long-term viability of the graft is needed.
Reading Ability in Primary Open-angle Glaucoma: Evaluation with Radner Reading Charts
Authors: Rolle Teresa , Dallorto Laura , Cafasso Riccardo , Mazzocca Roberto , Curto Daniela , Nuzzi Raffaele 
Published: December 2018

SIGNIFICANCEThis study determined the impact of visual disabilities caused by glaucoma on the patient's everyday life and emphasized the importance of developing strategies to improve reading ability in primary open-angle glaucoma (POAG) patients.PURPOSEThe purposes of this study were to investigate the reading performances of patients affected by POAG using the Italian version of the Radner Reading Charts and to test the presence of correlation between visual field (VF) damage and reading parameters.METHODSIn this cross-sectional observational study, all patients underwent a complete ophthalmic evaluation including VF testing and evaluation of reading performance using the Radner Reading Charts. The parameters for testing reading performance were reading acuity in logRAD, reading speed in words per minute, maximum reading speed, critical print size, and reading mistakes. Primary open-angle glaucoma and healthy groups were compared using the Mann-WhitneyUtest. The correlation between VF and reading parameters in glaucomatous eyes was assessed using Spearman correlation analysis. Based on VF mean deviation, each POAG patient had differences in reading performance between his/her best and worst eyes when compared using the paired Wilcoxon test. Statistical significance was set atP≤ .05.RESULTSEighty POAG patients and 60 healthy controls were enrolled. Glaucomatous subjects read slowly (166.63 ± 29.40 vs. 193.84 ± 26.20 words per minute,P< .0001) and made more mistakes than did healthy subjects. The critical print size for POAG patients was larger than the one for controls (0.52 ± 0.18 vs. 0.62 ± 0.16,P< .0001). Reading parameters showed a moderate correlation with VF mean deviation. The reading parameters were significantly impaired in the worst eye, and this result confirms the impact of VF loss on reading ability.CONCLUSIONSThis study demonstrated that glaucomatous patients read slowly and with more errors. Reading performances showed a good correlation with VF defect.
Video use in lecture classes: current practices, student perceptions and preferences
Authors: Alpert Frank , Hodkinson Chris S. 
Published: December 2018

Purpose
Despite the expansion of e-learning, higher education still involves live lectures, which students often see as “boring”. Lecture classes can be made more engaging and effective by including videos. However, empirical research is yet to report on current video use in lectures, or on student perceptions of and preferences for videos. The purpose of this paper is to fill that knowledge gap.

Design/methodology/approach
A two-stage mixed-method study used focus groups to gain a rich understanding of student’s video experiences, preferences and the types of videos they are shown. These understandings were utilised in a detailed on-line survey questionnaire, which was completed by a diverse sample of 773 university students, who responded about their recent in-class video experiences.

Findings
Students report that about 87 per cent of lecture classes included one or more videos. This paper reports on instructor practices, develops a video typology and reports on students’ preferred frequency, type of video, video source, video length and existing vs preferred video integration methods.

Practical implications
The results provide useful information for educational administrators. Recommendations are made for effective use of videos in lectures by instructors.

Originality/value
This is the first qualitative and survey research investigating current practice and student perceptions of video use during lecture classes. The authors also conduct the first survey with a broad sample across universities and academic disciplines using the unit of analysis of videos seen per course last week. Typologies of sources of videos, instructional functions, video facilitation techniques and types of videos used during lectures are proposed and then measured.
The application of citation count regression to identify important papers in the literature on non-audit fees
Authors: Staszkiewicz Piotr 
Published: December 2018

PurposeThis paper aims to show that when conducting a literature review, important papers can be identified by regressing citation counts on prior publications’ metadata.Design/methodology/approachThe method developed in this paper applies citation count regression analysis to identify important papers that may be overlooked when conducting literature reviews on subject areas with a large population of studies.FindingsThe developed method reduces a literature down to a small sample of important papers for further narrative analysis.Research limitations/implicationsAlthough the most widely used citation count database was used for research, there is a risk that a paper is not indexed; thus, it would be out of the scope of the literature.Practical implicationsThe developed method allows both preliminary selection of important papers for literature review, and robustness and completeness checks for already conducted narrative reviews.Originality/valueThis paper develops an automated search method for identification of important papers based on citation counts. This method allows for the reduction of big samples of research papers into smaller heterogenic subsamples. Like meta-analysis, this method is a quantitative technique that can enhance traditional narrative literature reviews.
The implementation of a nationwide anomaly screening programme improves prenatal detection of major cardiac defects: an 11‐year national population‐based cohort study
Authors: Hautala J , Gissler M , Ritvanen A , Tekay A , Pitkänen‐Argillander O , Stefanovic V , Sarkola T , Helle E , Pihkala J , Pätilä T , Mattila IP , Jokinen E , Räsänen J , Ojala T 
Published: December 2018

ObjectiveTo evaluate whether a nationwide prenatal anomaly screening programme improves detection rates of univentricular heart (UVH) and transposition of great arteries (TGA), and whether maternal risk factors for severe fetal heart disease affect prenatal detection.DesignPopulation‐based cohort study.SettingNationwide data from Finnish registries 2004–14.PopulationA total of 642 456 parturients and 3449 terminated pregnancies due to severe fetal anomaly.MethodsPrenatal detection rates were calculated in three time periods (prescreening, transition and screening phase). The effect of maternal risk factors (obesity, in vitro fertilisation, pregestational diabetes and smoking) was evaluated.Main outcome measuresChange in detection rates and impact of maternal risk factors on screening programme efficacy.ResultsIn total, 483 cases of UVH and 184 of TGA were detected. The prenatal detection rate of UVH increased from 50.4% to 82.8% and of TGA from 12.3% to 41.0% (P < 0.0001). Maternal risk factors did not affect prenatal detection rate, but detection rate differed substantially by region.ConclusionsA nationwide screening programme improved overall UVH and TGA detection rates, but regional differences were observed. Obesity or other maternal risk factors did not affect the screening programme efficacy. The establishment of structured guidelines and recommendations is essential when implementing the screening programme. In addition, a prospective screening register is highly recommended to ensure high quality of screening.Tweetable abstractImplementation of a nationwide prenatal anomaly screening improved detection rates of UVH and TGA.
Age Gelation, Sedimentation, and Creaming in UHT Milk: A Review
Authors: Anema Skelte G. 
Published: December 2018

AbstractDemand for ultra‐high‐temperature (UHT) milk and milk protein‐based beverages is growing. UHT milk is microbiologically stable. However, on storage, a number of chemical and physical changes occur and these can reduce the quality of the milk. These changes can be sufficiently undesirable so as to limit acceptance or shelf life of the milk. The most severe changes in UHT milk during storage are age gelation, with an irreversible three‐dimensional protein network forming throughout, excessive sedimentation with a compact layer of protein‐enriched material forming rapidly at the bottom of the pack, and creaming with excessive fat accumulating at the top. For age gelation, it is known that at least two mechanisms can lead to gelation during storage. One mechanism involves proteolytic degradation of the proteins through heat‐stable indigenous or exogenous enzymes, destabilizing milk and ultimately forming a gel. The other mechanism is referred to as a physico‐chemical mechanism. Several factors are known to affect the physico‐chemical age gelation, such as milk/protein concentration, heat load during processing (direct compared with indirect UHT processes), and milk composition. Similar factors to age gelation are known to affect sedimentation. There are relatively few studies on the creaming of UHT milk during storage, suggesting that this defect is less common or less detrimental compared with gelation and sedimentation. This review focuses on the current state of knowledge of age gelation, sedimentation, and creaming of UHT milks during storage, providing a critical evaluation of the available literature and, based on this, mechanisms for age gelation and sedimentation are proposed.
Environmental DNA (eDNA) metabarcoding reveals strong discrimination among diverse marine habitats connected by water movement
Authors: Jeunen Gert‐Jan , Knapp Michael , Spencer Hamish G. , Lamare Miles D. , Taylor Helen R. , Stat Michael , Bunce Michael , Gemmell Neil J. 
Published: December 2018

AbstractWhile in recent years environmental DNA (eDNA) metabarcoding surveys have shown great promise as an alternative monitoring method, the integration into existing marine monitoring programs may be confounded by the dispersal of the eDNA signal. Currents and tidal influences could transport eDNA over great distances, inducing false‐positive species detection, leading to inaccurate biodiversity assessments and, ultimately, mismanagement of marine environments. In this study, we determined the ability of eDNA metabarcoding surveys to distinguish localized signals obtained from four marine habitats within a small spatial scale (<5 km) subject to significant tidal and along‐shore water flow. Our eDNA metabarcoding survey detected 86 genera, within 77 families and across 11 phyla using three established metabarcoding assays targeting fish (16S rRNA gene), crustacean (16S rRNA gene) and eukaryotic (cytochrome oxidase subunit 1) diversity. Ordination and cluster analyses for both taxonomic and OTU data sets show distinct eDNA signals between the sampled habitats, suggesting dispersal of eDNA among habitats was limited. Individual taxa with strong habitat preferences displayed localized eDNA signals in accordance with their respective habitat, whereas taxa known to be less habitat‐specific generated more ubiquitous signals. Our data add to evidence that eDNA metabarcoding surveys in marine environments detect a broad range of taxa that are spatially discrete. Our work also highlights that refinement of assay choice is essential to realize the full potential of eDNA metabarcoding surveys in marine biodiversity monitoring programs.
MPK‐1/ERK is required for the full activity of resveratrol in extended lifespan and reproduction
Authors: Yoon Dong Suk , Cha Dong Seok , Choi Yoorim , Lee Jin Woo , Lee Myon‐Hee 
Published: December 2018

AbstractResveratrol (RSV) extends the lifespan of various organisms through activation of sirtuin. However, whether RSV‐mediated longevity is entirely dependent upon sirtuin is still controversial. Thus, understanding additional mechanisms concerning the genetic requirements for the biological activity of RSV needs to be clarified to utilize the beneficial effects of RSV. In this study using Caenorhabditis elegans as a model system, we found that MPK‐1 (an ERK homolog) signaling is necessarily required for RSV‐mediated longevity of sir‐2.1/sirtuin mutants as well as for wild‐type worms. We demonstrated that MPK‐1 contributes to RSV‐mediated longevity through nuclear accumulation of SKN‐1 in a SIR‐2.1/DAF‐16 pathway‐independent manner. The positive effect of RSV in regulating lifespan was completely abolished by RNA interference against mpk‐1 in the sir‐2.1 and daf‐16 mutants, strongly indicating that the MPK‐1/SKN‐1 pathway is involved in RSV‐mediated longevity, independently of SIR‐2.1/DAF‐16. We additionally found that RSV protected worms from oxidative stress via MPK‐1. In addition to organismal aging, RSV prevented the age‐associated loss of mitotic germ cells, brood size, and reproductive span through MPK‐1 in C. elegans germline. Therefore, our findings not only provide new mechanistic insight into the controversial effects of RSV on organismal longevity, but additionally have important implications in utilizing RSV to improve the outcome of aging‐related diseases.
IASB's independence in the due process: an examination of interest groups’ influence on the development of IFRS 9
Authors: Hewa Samindi Ishara , Mala Rajni , Chen Jinhua 
Published: December 2018

AbstractThis mixed‐method study examines whether and how the International Accounting Standards Board (IASB) was influenced by interest groups during the development of the expected credit loss (ECL) model for IFRS 9 Financial Instruments. Content analysis of 327 comment letters revealed that the IASB was influenced. However, Fisher's exact test and chi‐square goodness‐of‐fit test showed that, to a greater extent, the influence was not significant. Furthermore, qualitative analyses of the arguments put forward by interest groups showed that as a result of interest groups’ inputs, accounting requirements for the ECL model were made more operational, less complex and potentially productive of more comparable financial information.
The effects of experience versus description of attributes on willingness‐to‐pay for beefsteaks
Authors: Palma Marco A. , Johnson Myriah D. , Anderson David P. 
Published: December 2018

AbstractWe study the influence of the market environment in the beef industry by setting up an experiment in which the economic setting is changed from a “market purchasing” setting to a “tasting experience repurchasing” setting. In the market purchasing setting, subjects respond to a stated choice experiment for beefsteaks while shopping at a grocery store. This setting appeals more to the homegrown “purchase intention” and the results show that participants place more value on credence attributes rather than sensory attributes. In the experience repurchasing setting, subjects respond to the same discrete choice experiment (DCE), but the task is performed in a tasting facility where participants taste several steak products before making their choices. The experience repurchasing treatment appeals more to repurchase intentions and the results show that participants valued more the physical and sensory attributes of the beefsteaks. The information provided in this article is useful for the beef industry to understand the key drivers of market penetration purchasing based on attribute descriptions and repurchase intention based on experiencing physical and sensory attributes of beefsteaks.
Pluralising Political Forests: Unpacking “the State” by Tracing Virunga's Charcoal Chain
Authors: Marijnen Esther , Verweijen Judith 
Published: December 2018

AbstractPeering through the lens of illegal charcoal production in the forested areas of Virunga National Park in eastern Democratic Republic of the Congo, this paper makes a case for disaggregating the notion of “the state” to better capture “the political” in contemporary political forests. It argues that to identify the fluctuating importance of different dimensions of “stateness”, it is crucial to acknowledge the polymorphous socio‐spatial relations that produce political forests. Thus, we draw on the notions of territory, place, scale and network (TPSN) to examine how “stateness” in Virunga has transformed under the particularisation, transnationalisation, and regionalisation of authority. This approach allows us to show how these processes do not only stem from neoliberalisation, but are also driven by, inter alia, regional warfare and non‐state militarisation. The resulting complexity of the regulatory landscape turns Virunga into a space marked by a plurality of partly overlapping and partly conflicting political forests.
How do we evaluate the role of focal/grid photocoagulation in the treatment of diabetic macular edema?
Authors: Blindbæk Søren L. , Peto Tunde , Grauslund Jakob 
Published: December 2018

AbstractVascular endothelial growth factor inhibitors (anti‐VEGF) have consistently demonstrated efficacy and safety and changed both the aim and perspectives of diabetic macular edema (DME) treatment. Hence, the present and future role of focal/grid laser photocoagulation in DME treatment has been subjected to some debate. However, extensive insight into technical advances in novel laser systems, treatment protocols of anti‐VEGF trials and the functional impact of modern focal/grid photocoagulation is needed to evaluate the present and future role of photocoagulation in DME treatment. Across a wide range of clinical trials laser therapy was required as adjunctive/rescue treatment in approximately 20–50% of patients receiving anti‐VEGF monotherapy for centre involving DME. Further, a lower retreatment rate and a more stable reduction in retinal thickness have been demonstrated in more studies. However, lacking information on the laser systems used, their technical specifications and protocols of application often complicates direct comparison of results in anti‐VEGF trials. Hence, this paper aimed to provide an overview of the currently available data relevant to the potential role of focal/grid laser photocoagulation in DME treatment including a thorough overview of the current most commonly used laser systems. Results with subthreshold diode micropulse laser photocoagulation are intriguing and may offer a valuable option as adjunctive therapy to anti‐VEGF treatment. However, more well‐designed studies on combination therapy are warranted to determine the full potential of modern retinal photocoagulation systems. In conclusion, current data suggest that focal/grid laser therapy should still be an option for consideration as adjunctive therapy in many patients.