bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transanale totale mesorektale Exzision – Voraussetzungen zur sicheren Implementierung
Authors: Kneist Werner 
Published: August 2019

ZusammenfassungDie transanale totale mesorektale Exzision (TaTME) ist eine innovative und technisch anspruchsvolle Methode zur chirurgischen Behandlung des Rektumkarzinoms. Ziel dieses Artikels ist es, die Voraussetzungen und Trainingsbedingungen darzustellen, die für die sichere Implementierung dieses komplexen Verfahrens entscheidend sind. Die internationalen Expertenmeinungen werden vor dem Hintergrund der veröffentlichten Ergebnisse aus TaTME-Schulungszentren diskutiert. Darüber hinaus werden eigene Erfahrungen aus den TaTME-Anatomiekursen (Video) und einer ersten klinischen Serie von 102 TaTMEs mitgeteilt. Das Verfahren sollte in erster Linie von kolorektal spezialisierten Fachärzten für Chirurgie durchgeführt werden. Zunächst ist aber ein strukturiertes Schulungsprogramm an ausgewiesenen Aus- und Weiterbildungszentren obligatorisch. Ein Training am Körperspender und ein Proctoring für die ersten klinischen Fälle sind für eine sichere Implementierung der TaTME erforderlich. Die TaTME-Schulungskonzepte müssen weiterhin validiert werden. Die statistischen Auswertungen erster Fallserien deuten auf Lernphasen hin, die mindestens 40 Operationen umfassen. Hiernach werden niedrigere Komplikationsraten und eine akzeptable TME-Qualität erreicht. Auch in vorliegender Fallserie nahm die Morbidität nach > 40 Fällen signifikant ab (Clavien-Dindo ≥ III: 29 vs. 9%). Die Indikation wird bei besonders hohem Risiko (Median: 6 Risikofaktoren, Streubreite: 4 – 8) für ungenügende TME-Qualität und kritisch eingeschränkte Funktionalität gestellt. Für High-Volume-Zentren mit einer Konzentration von entsprechend selektierten Patienten wird eine TaTME-Frequenz von 20 pro Jahr empfohlen. Strukturierte Schulungsprogramme für TaTME sind notwendig und sollen vor der Einführung in die Klinik durchlaufen werden. Der Case-Volume-Effekt und die individualisierte Indikation führen zur Konzentration der Methode an spezialisierten Zentren.
Safety and Efficacy of Placenta-Derived Mesenchymal Stem Cell Treatment for Diabetic Patients with Critical Limb Ischemia: A Pilot Study
Authors: Wang Jiao , Zeng Xiang-Xia , Cai Wei , Han Zhi-Bo , Zhu Ling-Yan , Liu Jian-Ying , Xu Ji-Xiong 
Published: August 2019

Abstract
Aim Diabetic foot has become the main cause of non-traumatic amputation. Stem cell therapy, especially mesenchymal stem cells (MSCs), holds a great promise as a therapy for diabetic foot with ischemia limb arterial disease. The aim of this pilot study is to evaluate the safety and efficacy of placenta-derived MSCs (P-MSCs) treatment for diabetic patients with critical limb ischemia (CLI).
Methods Four eligible diabetic patients with CLI were consecutively enrolled in this pilot study. On the base of the standard-of-care treatment, these patients accepted P-MSCs treatment by intramuscular injection for successive 3 times at an interval of 4 weeks, and the safety and efficacy of placenta-derived MSCs (P-MSCs) treatment were evaluated.
Results There were no serious adverse events during the period of P-MSCs injection and the 24-weeks follow-up period. The clinical ischemic features of patients were improved 24 weeks after P-MSCs treatment. The scores of resting pain and limb coldness significantly decreased, and pain-free walking distance significantly increased from baseline to 24 weeks after P-MSCs therapy. The resting ankle brachial index increased, but no statistically significant difference was found. The findings of magnetic resonance angiography showed the increase of collateral vessel formation in one patient, but there were no significant changes observed in the other patients.
Conclusions The data in this pilot study indicated that multiple intramuscular P-MSCs injections may be a safe and effective alternative therapy for diabetic patients with CLI, and larger, placebo-controlled, perspective studies are needed to prove these results.
All I Have Learned, I Have Learned from Google: Why Today's Facial Rejuvenation Patients are Prone to Misinformation, and the Steps We can take to Contend with Unreliable Information
Authors: Mehta Neil , Gupta Amar , Nissan Michael 
Published: August 2019

AbstractA growing number of patients are seeking answers for their health concerns online. This study assesses the reliability, quality, and readability of online materials patients have access to through the Internet and evaluates the social media presence of information providers. An online search was conducted for facial rejuvenation by utilizing three ubiquitously used web search engines: Google, Bing, and Yahoo. The first 25 result pages were collected from each search engine, and exclusionary criteria were applied to exclude online stores and advertisements. Website reliability and quality were assessed via the DISCERN method. Readability was measured through six measurements: Flesch–Kincaid Grade Level (FKGL), Gunning Fox score, SMOG index, Coleman Liau index, and automated readability index. Social media presence and profile followers on Facebook, Twitter, and Instagram were determined to gauge social media presence. Exclusionary criteria yielded 41 unique websites, with the majority of websites authored by physicians (54%) followed by professional organizations (19%). The DISCERN method demonstrated that journal websites yielded the highest overall quality (4.00) and physician websites yielded the lowest (2.72). Readability analysis demonstrated that online forums proved the most challenging to read, and encyclopedia articles were the least challenging. Physician websites maintained the highest social media presence (95%) followed by professional organizations (75%). However, professional organizations had more social media followers in comparison to physician websites. Physician websites and professional organizations overwhelmingly command social media presence compared to other information providers and provide information with serious deficits in reliability and quality. A strong majority of online information also surpasses the health care literacy of patients. This poses a serious concern for physicians who need to provide and guide patients to high quality and reliable information.
Ultrasound to Localize the Peripherally Inserted Central Catheter Tip Position in Newborn Infants
Authors: Ren Xiao-Ling , Li Hong-Lei , Liu Jing , Chen Ya-Juan , Wang Man , Qiu Ru-Xin 
Published: August 2019

Objective This study aimed to evaluate the application of ultrasound for the localization of the tip position of peripherally inserted central catheters (PICCs) in newborn infants.
Study Design This study was a retrospective analysis on ultrasonic localization for PICC placement conducted in our department over the past 2 years. Ultrasonic localization was performed immediately after PICC placement in all neonatal patients. Successful PICC placement was confirmed if the PICC tip position was located at the inferior/superior cavoatrial junction. Chest X-ray localization was performed on 32 infants immediately after ultrasound examination to compare the accuracy of ultrasound localization.
Results Of the 186 patients, 174 (93.5%) had successful PICC placement on the first attempt. In 11 (5.9%) patients, the catheter tip was placed beyond the ideal location as follows: too deep (in the right atrium) in 4 patients, too shallow in 4 patients, and malpositioned in 3 patients. Both the sensitivity and the specificity of ultrasound for identifying PICC tip localization were 100%. Complications occurred in 2.7% of this group of patients.
Conclusion Ultrasonic localization of the PICC tip position is a timely, accurate, and reliable method and can identify the catheter tip with high accuracy. This method could be widely applied in neonatal wards.
A dynamical motif comprising the interactions between antigens and CD8 T cells may underlie the outcomes of viral infections
Authors: Baral Subhasish , Antia Rustom , Dixit Narendra M. 
Published: August 2019

Significance
Viral infections have different outcomes in different individuals. They could be cleared spontaneously, turn chronic, or cause host death due to tissue damage. Identifying what determines these outcomes has been a longstanding challenge in immunology. Many factors, including viral inoculum size and host genetics, that influence the outcomes have been identified, suggesting that a complex interplay of numerous factors determines the outcomes. In striking contrast, we argue that the outcomes are determined by a dynamical motif comprising a few, essential interactions between viral antigens and CD8 T cells. The other factors influence the outcomes indirectly by modulating these essential interactions. The motif presents a conceptual understanding of the outcomes, explains several confounding experimental observations, and proposes interventions.
DMBT1 suppresses progression of gallbladder carcinoma through PI3K/AKT signaling pathway by targeting PTEN
Authors: Sheng Shen , Jiwen Wang , Dexiang Zhang , Bohao Zheng , Yueqi Wang , Han Liu , Xiaoling Ni , Tao Suo , Liu Houbao 
Published: August 2019

ABSTRACT
Gallbladder carcinoma (GBC) is a highly lethal malignancy of the gastrointestinal tract. Despite extensive research, the underlying molecular mechanism of GBC remains largely unclear. Deleted in malignant brain tumors 1 (DMBT1) is low-expression during cancer progression and as a potential tumor-suppressor gene in various types of cancer. However, its role in Gallbladder cancer remains poorly understood. Here, we found that DMBT1 was significantly low-expression and deletion of copy number in GBC tissues by qRT-PCR and Western blot. Overexpression of DMBT1 impaired survival, promoted apoptosis in GBC cells in vitro, and inhibited tumor progression in vivo. Further study of underlying mechanisms demonstrated that DMBT1 combined with PTEN which could stabilize PTEN protein, resulting in inhibiting the activation of PI3K/AKT signaling pathway. Our study revealed a new sight of DMBT1 as a tumor-suppressor gene on the PI3K/AKT pathway in GBC, which may be a potential therapeutic target for improving treatment.
Highly reliable and selective ethanol sensor based on α-Fe2O3 nanorhombs working in realistic environments*
Authors: Yan Wenjun , Zeng Xiaomin , Liu Huan , Guo Chunwei , Ling Min , Zhou Houpan 
Published: August 2019

Abstract
A highly reliable and selective ethanol gas sensor working in realistic environments based on alpha-Fe2O3 (α-Fe2O3) nanorhombs is developed. The sensor is fabricated by integrating α-Fe2O3 nanorhombs onto a low power microheater based on micro-electro-mechanical systems (MEMS) technology. The α-Fe2O3 nanorhombs, prepared via a solvothermal method, is characterized by transmission electron microscopy (TEM), Raman spectroscopy, x-ray diffraction (XRD), and x-ray photoelectron spectroscopy (XPS). The sensing performances of the α-Fe2O3 sensor to various toxic gases are investigated. The optimum sensing temperature is found to be about 280 °C. The sensor shows excellent selectivity to ethanol. For various ethanol concentrations (1 ppm–20 ppm), the response and recovery times are around 3 s and 15 s at the working temperature of 280 °C, respectively. Specifically, the α-Fe2O3 sensor exhibits a response shift less than 6% to ethanol at 280 °C when the relative humidity (RH) increases from 30% to 70%. The good tolerance to humidity variation makes the sensor suitable for reliable applications in Internet of Things (IoT) in realistic environments. In addition, the sensor shows great long-term repeatability and stability towards ethanol. A possible gas sensing mechanism is proposed.
Finite element modeling and updating of the composite plate structure
Authors: Yaacob R M , Hashim M A H , Sani M S M 
Published: August 2019

Abstract
Composite plate structure is broadly used in engineering structures for automotive and aerospace applications. Furthermore, the problem in vibrational is one of the industries main challenges. Composite materials are frequently used in industry for weight and cost reduction to enhance mechanical properties in structural components. This research aims to execute a composite plate structure model updating procedure. Through finite element analysis (FEA) and experimental modal analysis (EMA), modal parameters such as natural frequencies, mode shapes, and damping ratios are collected. Composite plate structure is set to be free-free boundary condition and node equivalence is done in the surface plate area. Correlation is executed between these two data sets. The discrepancies in natural frequencies between FEA and EMA were reduced with the selected parameters identified to perform structure updating model using sensitivity analysis.
Updating of the Dynamic Behaviour of an Assembled Structure with Bolted Joints in Light of EMA Results
Authors: Omar R , Rani M N Abdul , Yunus M A , Isa A A M , Rahman Z A 
Published: August 2019

Abstract
Bolted joints, which contribute significantly to minimise the magnitudes of resonant peaks of assembled structures and give easy-to-install and uninstall, have been widely used in various types of mechanical structural assembly and. However, modelling of an individual bolted joint within a large assembled structure has always been problematic, especially when it comes to predicting dynamic behaviour. The aim of this paper is to put forward an idea of efficiently and economically modelling of bolted joints of an assembled structure focusing on the bolting and assembly interfaces. The finite element (FE) models of individual components (Plate A and Plate B), bolting and assembly interfaces were developed using the NX11 Simcenter 3D software. Normal modes analysis was carried out for the initial FE models of the individual components and the assembled structure. Experimental modal analysis (EMA) was performed to determine the modal parameters of the individual components and assembled the structure. It was found that a low correlation between the initial FE models and EMA has been recorded. The initial FE models were then tuned in the light of EMA results in order to improve their accuracy and reliability. The proposed updating procedure has been successfully used in improving the low correlation which is largely due to the inaccurate modelling of the bolted joints.
Removal of Dust from the Solar Panel Surface using Mechanical Vibrator
Authors: Attia Osam H. , Adam Nor Mariah , As’arry Azizan , Md Rezali Khairil Anas 
Published: August 2019

Abstract
Soiling and its effect on the performance of solar modules are generally of high concern for regions with a high deposition of dust and low frequency and less intensity of rainfall. The procedure of removing dust using traditional methods is capital and labour intensive. Additionally, most of the cleaning methods consumed power from the energy produced by the solar system. Therefore, the main objective of this study is to investigate the effect of vibration magnitude on the dust removal index of solar panel. In this work, wind energy was transformed into mechanical energy i.e. vibration. The mechanical vibrator attached to a panel produced harmonic excitation force to overcome the adhesive force between the dust particles and the surface of the solar panel. The generated vibration force has a linear relationship with the air velocity. This new designed and fabricated system was able to remove 3.5 gram of dust out of 5 grams on the panel with a vibration force of 3.128 N at a tilt angle of 15°. The new system has effectively proven that wind energy if being converted into vibration force can be used for dust removal from the solar panel surface.
Biodynamic Modelling of Hand for Glove Transmissibility Prediction using Artificial Neural Networks
Authors: Rahman Tuan A Z , Rezali K A M , As’arry A , Jalil N A A 
Published: August 2019

Abstract
Prediction of glove transmissibility to the hand plays an important role in order to improve its vibration reduction capability. This study presents a non-parametric biodynamic modelling of the hand based on artificial neural networks (ANNs) model for predicting the apparent mass in order to estimate the transmissibility of a glove to the hand. An experimental investigation was carried out to obtain the input-output vibration data using five subjects. Then, an ANNs model was used to map between the input and the output with its weight and bias parameters optimized using chaos-enhanced stochastic fractal search (CFS) algorithm. The results indicate that the developed ANNs hand model capable to predict the apparent mass of the human hand with an average accuracy of 97.67%.
Application of the Structural Dynamic Modification Method to Reduce the Vibration of the Vehicle HVAC System
Authors: Satar MHA , Mazlan AZA , Hamdan MH , Md Isa MS , Man S , Paiman MAR , Abd Ghapar MZ , Sulaiman MSA 
Published: August 2019

Abstract
Heating, ventilating and air conditioning (HVAC) system is one of the major sources for the vehicle noise and vibration, which subsequently contribute to the bad acoustical environment. The components of the HVAC system can produce a significant level of vibration during the operation and contributed to an unwanted noise. As the vibration of HVAC components get worse, it will be transferred to other components and excites the natural frequencies of the HVAC system. Natural frequencies of the components are depending on the mass and stiffness of the HVAC components and the value can been modify using these two parameters. This study is focusing on the specific type of HVAC noise and vibration problem and the counter measure has been perform by implementing the structural dynamic modification (SDM) method to the air conditioning (AC) pipe. The lab-scale of the vehicle HVAC system is set up to represent the actual HVAC system with the real vehicle operation. Noise and vibration of the HVAC system in the system level are measured and compared. From this data, the Dynamic Vibration Absorber (DVA) is designed and applied at the AC pipe of the HVAC system. The result shows that, the natural frequency of the AC pipe can be shifted which resulting a wide effective frequency range of 100-500 Hz. The effect of DVA on the HVAC system is observed during operation whereby a significant vibration attenuation has been achieved for operating frequency range of 100-300 Hz.
Effect of flattening reduction rate of primary recrystallization microstructure and rare earth in copper-containing grain-oriented silicon steel on secondary recrystallization
Authors: Jin Zi-li , Ren Hui-ping , Zhang Zhi-nan , Wu Zhong-wang 
Published: August 2019

Abstract
The results show that the content of rare earth and the flattening reduction rate after the initial recrystallization annealing have significant effects on the secondary recrystallization process and grain growth behavior in the copper oriented silicon steel produced by the first cold rolling method. After the initial recrystallization of the oriented silicon steel containing copper, the flattening with a reduction ratio of about 9%, relatively coarse recrystallized grains are obtained after high temperature annealing. About 8 ppm of lanthanum and 3 ppm of cerium were added to the oriented silicon steel containing copper, the temperature at which the secondary recrystallization abnormally grew during the high temperature annealing was increased by 30 °C ∼50 °C . After the primary recrystallization annealing, the secondary recrystallized structure of copper-oriented silicon steel containing rare earth is relatively coarse after being flattened.
Cold Rolling Reduction Dependence of the Recrystallization Texture of 3% Si Non-oriented Electrical Steel
Authors: Seil Lee , De Cooman Burno C. 
Published: August 2019

Abstract
The effect of the amount of cold reduction on the crystallographic texture, the microstructure, and the magnetic properties of cold rolled and annealed 3% Si non-oriented (NO) Si steel has been studied. The results indicate that, at constant final thickness, the combination of initial hot-rolled sheet thickness and the cold rolling reduction had a significant influence on the B50 magnetic flux density. The initial thickness of the hot-rolled sheet did not affect the crystallographic texture of the as-hot rolled sheet and the annealed hot-rolled sheet. At constant final thickness, the combination of a larger hot-rolled sheet thickness and a higher cold rolling reduction resulted in the decrease of the B50 magnetic flux density. This was due to an increase of the {411}<148> and {111}<112> texture components intensity and a decrease of the {110}<001> texture component intensity.
Evolution of recrystallization texture in non-oriented electrical steels during final annealing – influence of shear stress after cold rolling
Authors: Bacroix B , Schneider J , Franke A 
Published: August 2019

Abstract
The fabrication process of non-oriented electrical steels comprises hot rolling, annealing of the hot band (optional), cold rolling and final annealing. Starting from different hot band, quite distinct deformation substructures have been observed after cold rolling of ferritic FeSi steels. The recrystallization texture after annealing of the cold rolled material depends on the deformation structure obtained after cold rolling. In the present paper, a simple method to evaluate the energy stored during cold deformation of Fe-Si steels is presented. An estimate of the stored energy has then been made for various deformation modes (in-plane compression superimposed with shear stress). It is shown that, by adding a shear component, a more appropriate explanation of the experimental observed recrystallization textures may be obtained. The existence of shear components produces an inversion of the soft and hard orientations with respect to the case of a pure in-plane strain compression.
Effect of pearlite morphology on recrystallization behaviour in cold rolled high strength automotive steel sheets
Authors: Janakiram S , Gautam J , Kestens L A I 
Published: August 2019

Abstract
The present study is mainly focused on recrystallization behaviour and associated microstructure and texture evolution with the effect of second phase as pearlite. Two cold rolled sheets with 80% cold reduction consisted of coarse and fine pearlite bands along with ferrite. Cold rolling was followed by interrupted annealing at different soaking time to study the kinetics and recrystallization texture evolution. Results are analysed with the help of micro-Vickers hardness, microstructure and texture analysis through SEM and Electron Backscattered Diffraction (EBSD). Results clearly show the effect of pearlite band size on recrystallization kinetics and texture evolution. Faster recrystallization is observed for fine pearlite band compared to coarse band. Heterogeneous nucleation of grains took place at ferrite pearlite interface, grain boundaries of RD-ND orientations and within the deformed ferrite. Fragmentation and spherodization of pearlite lamellae takes place inside the colony of pearlite with increase in soaking time.
Microstructure, texture, and mechanical behaviour of warm-rolled and annealed standard duplex stainless steel
Authors: Dias F L , Tavares T B , Santos D B 
Published: August 2019

Abstract
The microstructural evolution and mechanical behaviour of 2205-type duplex stainless steel were studied after plate warm rolling at 600 °C with 60% and 80% thickness reduction and subsequently annealed at 1050 °C for 300 s. With increasing thickness reduction level, ferrite-phase α-fibre became weaker and γ-fibre was developed. For the austenite phase, a weakening of Brass component and increases in Goss and Copper components was observed. A transition from bamboo type into a pearl structure from the 60% sample to the 80% warm-rolled annealed sample was observed. An average tensile strength of 794 MPa was assessed through tensile tests. Post deformation tests demonstrated an increase in microhardness toward the fractured areas and a deformation-induced martensitic transformation was observed in transmission electron microscope results in those regions for all conditions.