bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital inclusive finance and digital transformation of Chinese enterprises: Perspectives on company technology intensity and financialization
Authors: Xu Qian , Cao Qun , Wang Liyan 
Published: November 2024

AbstractThis study explores the role of digital inclusive finance in company digital transformation within China, particularly examining the variances among companies with differing levels of technological intensity and financialization. Using A‐share Chinese data from 2011 to 2022, we find that regions with superior digital inclusive finance exhibit enhanced corporate digital transformation, regardless of the provincial or municipal level. Subindexes, including the coverage breadth, use depth, and degree of digital inclusive finance, confirm that they are all significantly positively related to digital transformation. These effects are more pronounced in companies with lower technological intensity, and corporate financialization serves as a mediating factor.
Immunophenotyping for the Assessment of Asymptomatic Lymphocytosis: A Retrospective Analysis and National Survey
Authors: Freeman Tanya , Johnstone Peter , Hibbs Stephen P. , Assefa Esubalew , Araf Shamzah , Farren Timothy , Butler Tom 
Published: November 2024

ABSTRACTAsymptomatic lymphocytosis poses a common challenge in haematology. Immunophenotyping can establish whether a clonal population is present, but it is expensive and the benefit of diagnosing asymptomatic patients is unproven. This study aimed to establish data to guide the use of immunophenotyping. We analysed the proportion of lymphocytosis in full blood count (FBC) samples across a five‐year period within a large UK National Health Service (NHS) trust. Persistent lymphocytosis was present in 0.18% (437/242678) of repeat community samples. Of samples sent for immunophenotyping, 743/784 (95%) with a lymphocyte count > 10 × 109/L had a clonal population, compared to 223/1696 (14%) with a lymphocyte count < 5 × 109/L. We followed up a longitudinal cohort of asymptomatic patients with clonal lymphocytosis to determine how many required treatment. The minority (11/46) of patients needed treatment within 9 years of follow‐up. Of patients needing treatment, 10/11 (91%) had a presenting lymphocyte count > 10 × 109/L. In all cases, treatment was initiated when the patient became symptomatic. We propose a lymphocyte count threshold of > 10 × 109/L for referral and immunophenotyping in patients with asymptomatic lymphocytosis. This approach aims to balance safety and cost‐effectiveness and reflects uncertainty in the value of diagnosis for asymptomatic patients.
Tracking myasthenia gravis severity over time: Insights from the French health insurance claims database
Authors: Attarian Shahram , Camdessanché Jean‐Philippe , Echaniz‐Laguna Andoni , Ciumas Mariana , Blein Cécile , Grenier Benjamin , Solé Guilhem 
Published: November 2024

AbstractBackground and purposeFew data are available on the course of myasthenia gravis (MG) regarding disease severity and stability over time in real‐world settings. This study used the French National Health Insurance Database (SNDS) to assess markers of disease severity in patients with MG longitudinally.MethodsAll patients with MG‐related claims in the SNDS between 2013 and 2020 were identified. Patients were followed for up to 8 years after the first claim. Intensive care unit (ICU) stays, treatment with intravenous immunoglobulin (IVIg) or plasma exchange (PE), and death were documented throughout the follow‐up period. Standardized mortality rates were estimated, and mortality‐related variables were identified using a Cox model.ResultsIn all, 14,459 individuals constituted the full study population, including 6354 incident patients. In the incident population, 2199 (34.6%) were admitted to ICUs at least once, principally during the first year after the index date (N = 1477; 23.3%). This proportion decreased progressively to reach 3.0% in the seventh year. A total of 2817 patients received IVIg and 432 PE, again principally in the first year. In the full study population, the standardized mortality rate was 1.08 (95% confidence interval [CI] 1.03–1.13), being lower in men (0.95, 95% CI 0.89–1.02) than in women (1.15, 95% CI 1.07–1.23) and in patients aged >65 years (1.06, 95% CI 1.01–1.11) than in younger patients (1.50, 95% CI 1.24–1.76). Male gender, older age and higher comorbidity were independently associated with mortality.ConclusionsA subgroup of patients with MG require ICU admission and rescue therapy with IVIg or PE, indicative of poor disease control. New therapies are needed to improve disease control and reduce disease burden.
Parental involvement in Mexican‐origin adolescents' romantic relationships: An examination of parents' cultural orientations and parent‐youth relationships
Authors: Duran Julissa G. , Updegraff Kimberly A. , Perez‐Brena Norma J. , Umaña‐Taylor Adriana J. 
Published: November 2024

AbstractRomantic relationships are normative in adolescence, and parents can play a role in supporting or restricting adolescents' romantic experiences. This study examined parents' involvement in adolescents' romantic relationships in a sample of 226 Mexican‐origin families. Findings indicated that, on average, mothers were more supportive of adolescents' romantic relationships than fathers, and parents were more supportive of daughters than of sons. Fathers' (but not mothers') Mexican cultural orientations were associated with greater restrictions on adolescents' romantic relationships. For mothers of boys, higher levels of familism values were linked to lower levels of support, and for fathers of boys, more traditional gender role attitudes were associated with less support. Also, more parent–youth conflict was associated with greater support from mothers but greater restrictions from both mothers and fathers. Finally, less granted autonomy in early adolescence was associated with greater parental restrictions. Discussion focuses on the nature of mothers' and fathers' involvement in adolescents' romantic relationships. Implications for research and practice highlight the importance of recognizing cultural and relational factors that shape mothers' and fathers' parenting around adolescent dating.
Peatland Fungal Community Responses to Nutrient Enrichment: A Story Beyond Nitrogen
Authors: Wang Meng , Lamit Louis J. , Lilleskov Erik A. , Basiliko Nathan , Moore Tim R. , Bubier Jill L. , Guo Galen , Juutinen Sari , Larmola Tuula 
Published: November 2024

ABSTRACTAnthropogenically elevated inputs of nitrogen (N), phosphorus (P), and potassium (K) can affect the carbon (C) budget of nutrient‐poor peatlands. Fungi are intimately tied to peatland C budgets due to their roles in organic matter decomposition and symbioses with primary producers; however, the influence of fertilization on peatland fungal composition and diversity remains unclear. Here, we examined the effect of fertilization over 10 years on fungal diversity, composition, and functional guilds along an acrotelm (10–20 cm), mesotelm (30–40 cm), and catotelm (60–70 cm) depth gradient at the Mer Bleue bog, Canada. Simultaneous N and PK additions decreased the relative abundance of ericoid mycorrhizal fungi and increased ectomycorrhizal fungi and lignocellulose‐degrading fungi. Fertilization effects were not more pronounced in the acrotelm relative to the catotelm, nor was there a shift toward nitrophilic taxa after N addition. The direct effect of fertilization significantly decreased the abundance of Sphagnum‐associated fungi, primarily owing to the overarching role of limiting nutrients rather than a decline in Sphagnum cover. Increased nutrient loading may threaten peatland C stocks if lignocellulose‐degrading fungi become abundant and accelerate decomposition of recalcitrant organic matter. Additionally, future changes in plant communities, strong water table fluctuations, and peat subsidence after long‐term nutrient loading may also influence fungal functional guilds and depth‐dependencies of fungal community structure.
Re‐Equilibrating Sex Ratios: Adjustment of Reaction Norms in Species With Temperature‐Dependent Sex Determination
Authors: Santidrián Tomillo Pilar 
Published: November 2024

ABSTRACTFisher's general principle for sex allocation holds that population sex ratios are typically balanced because parents producing the rare sex are benefited and the rare sex alternates over time. In species that have temperature‐dependent sex determination (TSD), thermal reaction norms need to be adjusted at the population level to avoid extremely biased sex ratios and extinction. Extant species with TSD experienced drastic climatic changes in the geological past and must necessarily have mechanisms of adaptation. I propose here a conceptual framework to explain how TSD curves could be adjusted by means of natural selection, based on Fisher's equilibrium sex‐ratio principle. Through a process that alternatively favors mothers that tend to produce the rare sex under new temperatures, sex ratios eventually return toward a theoretical equilibrium. Prerequisites for this model are variability among mothers in the tendency to produce a particular sex at a given temperature (i.e., variability in the thermal reaction norm), inheritance of this trend, and higher fitness of the rare sex. This straightforward mechanism could facilitate thermal adaptation in species with TSD over multiple generations.
Potentials for Reducing Spatial Inequalities in Innovation: A Spatial Econometric Perspective
Authors: Bürscher Theresa , Scherngell Thomas 
Published: November 2024

ABSTRACTThis study explains disparities in regional innovation through specific features of regional knowledge bases, including recently discussed concepts such as, technological relatedness, knowledge complexity, and technological complementarity among neighboring regions and regions connected in R&D networks. We employ a spatial autoregressive panel model for 405 European regions to estimate the effects of these characteristics. While being connected to complementary regions and having a high region‐internal technological relatedness are conducive to regional innovation, knowledge complexity has no positive effect interestingly. In illustrative convergence scenarios, we demonstrate the potential of increasing relatedness and complementarity to reduce inequalities in Europe, pointing to important policy implications.
Accuracy of 3‐dimensional surgical guide for endodontic microsurgery with a new design concept: A cadaver study
Authors: Ha Se‐Won , Choi Stephanie M. , Kim Sunil , Song Minju , Hu Kyung‐Seok , Kim Euiseong 
Published: November 2024

AbstractAimDespite the high success rate of endodontic microsurgery (EMS), it is difficult to suggest EMS as a general treatment option considering the difficulty of the procedure. A surgical guide has been proposed to overcome this problem. This study aimed to evaluate the stability of the surgical guide of a new design concept, as well as the accuracy of root resection, and to introduce the manufacturing method of the newly designed surgical guide.MethodologyThe experiment was conducted on 59 roots (9 in the maxillary and 50 in the mandibular region) of adult human cadavers. The surgical guide was designed using CAD/CAM design software based on cone‐beam computed tomography (CBCT) images and optical scan files. Unlike conventional surgical guides, the surgical guide proposed herein was designed to act as a tooth‐bone‐supported removable appliance. Two different types of guides were prepared: the osteotomy guide (O guide) for separation of the cortical bone above the root tip with a trephine bur with an outer diameter of 6 mm and the root resection guide (R guide) for resection of the root tip with a trephine bur with an outer diameter of 4 mm. For stability evaluation, the guides were pressed at five predetermined locations after installation and checked for the presence of any movement. For accuracy evaluation, the length at which the root tip was cut was measured and examined by overlapping the preoperative and postoperative CBCT images.ResultsOf the 15 R guides, 14 were stably installed without mobility. For the R guide group, the root tip was resected with an average of 3.2 mm, showing better results than the no‐guide group with an average of 4.0 mm.ConclusionsThe newly designed surgical guide of this study can be applied more stably, enabling root resection to be performed more accurately and simply according to the preoperative plan than when performed without a guide.
Prognosis of chronic spontaneous urticaria with an inadequate response to omalizumab
Authors: Watanabe Haruka , Takahagi Shunsuke , Hayama Koremasa , Fukunaga Atsushi , Nakagawa Yukinobu , Inomata Naoko , Chinuki Yuko , Hide Michihiro 
Published: November 2024

AbstractBackgroundChronic spontaneous urticaria (CSU) exhibits notable responsiveness to omalizumab (OMA). The prognosis and subsequent therapeutic strategies warrant comprehensive exploration in cases exhibiting inadequate responses to OMA.MethodsWe conducted a multicenter retrospective analysis to investigate the 12‐month prognosis of patients inadequately responding to three injections of OMA. The endpoints encompassed identifying predictive factors for a favorable prognosis and assessing interventions related to an ameliorated prognostic outlook.ResultsThe study involved 48 patients who met the inclusion criteria. After three OMA administrations, therapeutic interventions included the continuation of OMA in 34 patients, systemic corticosteroids in seven patients, and immunosuppressants in 12 patients. After 12 months, 28 of the 48 patients exhibited a good prognosis, whereas the remaining 20 displayed a less favorable prognosis. Good prognostic determinants encompassed the duration of CSU within 51 weeks, the presence of angioedema, IgE levels ≤100 IU/mL pre‐OMA, blood eosinophil counts ≥100/mm3 post‐OMA, and urticaria control test (UCT) scores ≥5 pre‐OMA and ≥6 post‐OMA. Following the third OMA injection, the implementation of immunosuppressants presented an association with a good prognosis, while the employment of systemic corticosteroids correlated with an unfavorable prognosis.ConclusionsMore than half of patients inadequately responding to OMA achieved a good prognosis 12 months later. Several clinical variables appear to be predictive of prognosis, and certain therapeutic agents can be associated with prognostic outcomes.
Beyond change: Personality‐environment alignment at work
Authors: Ones Deniz S. , Stanek Kevin C. , Dilchert Stephan 
Published: November 2024

AbstractWe critically evaluate Dupré and Wille's (2024) proposal for using assessments for organizational personality development through the lens of empirical evidence on adult personality change. We present an overview of research on personality stability and malleability throughout adulthood examining rank‐order stability, mean‐level changes, and the impact of life events and interventions. Empirical evidence reveals that while personality exhibits some plasticity in young adulthood, significant changes become increasingly rare beyond age 30. For older employees, personality remains highly stable, making age an important consideration in workforce development. Life experiences and intentional interventions have been shown to prompt modest personality changes, with emotional stability being the most malleable trait. We quantify these changes, noting shifts of up to two‐thirds of a standard deviation in emotional stability through targeted interventions, with more limited effects on other Big Five traits. We also provide insights for organizational assessment practices, including the need for tailored personality (re‐)assessment intervals and age‐based norm composition for better utilization of personality information. With Cybernetic Trait Complexes Theory, we introduce a framework for aligning personality traits with situational cues in work environments. This approach emphasizes trait activation rather than personality modification, allowing organizations to harness employees' strengths by strategically designing environments that naturally encourage beneficial trait expression. This shifts the focus from personality change to strategic activation of beneficial traits through environmental design. We describe how organizations can leverage employees' existing personality trait complexes while fostering incremental behavioral adaptations, offering a pragmatic alternative to traditional employee development approaches. By aligning individuals with environments that activate their traits, organizations can enhance both personal and organizational outcomes, contributing to broader societal benefits as well.
The power of networking in science and academia
Authors: Borger Jessica G 
Published: November 2024

AbstractIn science and academia, success is often shaped by both knowledge and networking. Reflecting on nearly two decades in academic research, I recount my experience as a postdoctoral immunologist returning to Australia with limited local connections and support. Upon re‐establishing myself in Australia, I initially faced barriers that restricted my visibility and collaborations. A turning point came when personal challenges motivated me to actively network, leading to valuable collaborations and career opportunities. By initiating conversations with academic leaders and peers, I expanded my network and established numerous leadership roles, even as a “junior” postdoc through founding a symposium, engaging with an immunology society, volunteering on various academic and advocacy committees, contributing to public outreach and nationally advocating for gender equity in science. These experiences reinforced that networking is about fostering meaningful relationships and creating opportunities to grow professionally. I provide advice on how to increase your networks by volunteering at work, when attending conferences, through contributing to societies and building a social media presence. My journey highlights the importance of being proactive in building networks, which can open doors, amplify one's voice, and drive career advancement in science and academia.
Neoadjuvant chemotherapy in breast cancer: a retrospective pathway assessment in a regional cancer centre
Authors: Fitzpatrick Lachlan , Ho Hui Jan , Sabesan Sabe , Ariyarathna Dinuka , Ryan Corinne , Otty Zulfiquer , Bain Nathan , Tan Joanne , Brown Amy , Joshi Abhishek , Pathmanathan Shivanshan 
Published: November 2024

AbstractBackgroundThe optimal care pathway (OCP) for people with breast cancer provides a framework for investigation and management of patients with breast cancer, with delays previously identified regionally.AimWith emphasis on the neoadjuvant pathway, the primary aim of this study was to assess the practicality of implementing the breast cancer OCP timeframes regionally in comparison to nationally referenced standards.MethodsA retrospective institutional audit was performed for patients undergoing neoadjuvant therapy for breast cancer. The time from referral to specialist review, completion of investigations, discussion at multidisciplinary team (MDT) meetings, initiation of neoadjuvant chemotherapy (NACT) and surgery were calculated and compared to OCP.ResultsFifty‐three patients were included, with 19 patients living rurally (36%). Twenty‐four patients (45%) were seen by a specialist surgeon within 2 weeks of referral. Following surgical review, 44 patients (83%) completed investigations within 2 weeks, and 43 patient cases (81%) were discussed at MDT meetings within 2 weeks. Forty‐eight patients (91%) were commenced on neoadjuvant treatment within 4 weeks of decision to treat, and 43 patients (81%) underwent surgery within 6 weeks of neoadjuvant treatment completion. Delays from initial referral to NACT were more frequent in rural patients compared to urban (79% vs 94%, P < 0.05).ConclusionAdherence to OCP timeframes for patients undergoing neoadjuvant therapy in a regional centre was feasible and strategies are needed to bridge gaps identified for rural patients.
Augmented Reality Adoption: Exploring Security Concerns and Consumer Resourcefulness in the Era of Society 5.0
Authors: Mahajan Advitya Indu , Taggar Rashi 
Published: November 2024

ABSTRACTSociety 5.0, building its foundation on industry 4.0, defines the concept of super smart cities as places where humans can adapt novel technologies such as Augmented Reality (AR) in their daily lives. AR offers consumers an immersive, hybrid experience that blurs the line between the real and virtual worlds, prompting this research to explore factors influencing its adoption. Using a quantitative approach, the study analyzed survey data from 457 respondents through the PLS‐SEM‐ANN approach, applying a modified version of the UTAUT model. This research introduces a novel perspective by integrating previously unexplored factors, like security concerns and technostress, into the UTAUT model. Results indicate that personal innovativeness towards information technology and security concerns significantly drive AR adoption, while technostress and social influence are non‐significant. A possible explanation for the insignificance of these factors lies in the present generation's ability to rapidly adapt to new technologies and make autonomous decisions, reducing reliance on peer influence. These findings emphasize the role of consumer resourcefulness in closing the intention‐usage gap. Understanding these underlying factors and consumer behavior dynamics enables e‐commerce platforms to tailor engagement strategies, facilitating more effective AR adoption within the Society 5.0 framework.
Arrhythmogenicity of monophasic and biphasic PFA waveforms in a porcine model
Authors: Kumru Hanife Tugba , Mattison Lars , Tarakji Khaldoun G. , Verma Atul , Sigg Daniel C. 
Published: November 2024

AbstractObjectiveThe potential risk of inducing ventricular arrhythmias was explored by employing pulsed field ablation (PFA) through the administration of both monophasic and biphasic waveform deliveries.MethodsPFA was applied to specific locations in the right ventricle (RV, n = 5 sites) in swine (n = 2), utilizing identical settings with consistent amplitude, pulse width, and a number of pulses for both monophasic and biphasic waveforms. PFA deliveries were precisely timed in 10‐ms intervals across the entire T wave.ResultsUsing monophasic waveforms, ventricular fibrillation (VF) was induced 7/7 times when PFA pulses were delivered during the T wave. Biphasic waveforms resulted in no ventricular arrhythmias when PFA was delivered across the entire duration of T wave.ConclusionsOur findings indicate that VF can be consistently induced with monophasic pulse waveforms, but not with biphasic pulse waveforms in a porcine model.