bluuebunny/crossref_metadata_2025_split huggingface dataset:
Career success schemas and their contextual embeddedness: A comparative configurational perspective
Authors: Kaše Robert , Dries Nicky , Briscoe Jon P. , Cotton Richard D. , Apospori Eleni , Bagdadli Silvia , Çakmak‐Otluoğlu K. Övgü , Chudzikowski Katharina , Dysvik Anders , Gianecchini Martina , Saxena Richa , Shen Yan , Verbruggen Marijke , Adeleye Ifedapo , Babalola Olusegun , Casado Tania , Cerdin Jean‐Luc , Kim Najung , Mishra Sushanta Kumar , Unite Julie , Fei Zhangfeng 
Published: November 2018

AbstractWe introduce career success schemas as critical for understanding how people in different contexts perceive and understand career success. Using a comparative configurational approach, we show, in a study of 13 countries, that two structural characteristics of career success schemas—complexity and convergence—differ across country contexts and are embedded in specific configurations of institutional factors. Adopting complexity and convergence as primary dimensions, we propose a taxonomy of career success schemas at the country level. Based on this taxonomy, we contribute to the understanding of subjective career success across countries, discuss the importance of schemas for organisational career systems in multinational enterprises, and propose specific guidelines for future comparative careers research.
Revisiting the role of bone‐modifying agents in the management of metastatic prostate cancer
Authors: Cheung Foon‐Yiu 
Published: November 2018

AbstractBone metastases are a hallmark of advanced prostate cancer and may drive the morbidity and mortality of the disease in patients with a poor prognosis. The pathogenesis of bone metastasis involves the interaction between cancer cells, normal bone cells and the bone microenvironment. Targeting the bone microenvironment has become a promising therapy for patients with advanced prostate cancer and bone metastasis. This article reviews the use of the antiresorptive bone‐targeted agents zoledronic acid and denosumab in the management of skeletal‐related events (SREs) in patients with metastatic castration‐resistant prostate cancer (mCRPC) and bone metastasis. In real‐world clinical practice, these agents have been widely prescribed as a concomitant medication to novel mCRPC therapies, such as abiraterone, enzalutamide and radium‐223. International guidelines have recommended zoledronic acid or denosumab for the prevention of SREs in patients with bone metastasis from mCRPC. Although there is currently no consensus regarding the optimal sequencing between the bone‐targeted agents and novel anti‐cancer therapies, future optimal treatments for patients with bone metastasis from prostate cancer may involve the combination of these agents.
Real‐time parallel 3D multiple particle tracking with single molecule centrifugal force microscopy
Authors: KOU L. , JIN L. , LEI H. , HU C. , LI H. , HU X. , HU X. 
Published: November 2018

SummaryReal‐time tracking of multiple particles is key for quantitative analysis of dynamic biophysical processes and materials science via time‐lapse microscopy image data, especially for single molecule biophysical techniques, such as magnetic tweezers and centrifugal force microscopy. However, real‐time multiple particle tracking with high resolution is limited by the current imaging processes or tracking algorithms. Here, we demonstrate 1 nm resolution in three dimensions in real‐time with a graphics‐processing unit (GPU) based on a compute unified device architecture (CUDA) parallel computing framework instead of only a central processing unit (CPU). We also explore the trade‐offs between processing speed and size of the utilized regions of interest and a maximum speedup of 137 is achieved with the GPU compared with the CPU. Moreover, we utilize this method with our recently self‐built centrifugal force microscope (CFM) in experiments that track multiple DNA‐tethered particles. Our approach paves the way for high‐throughput single molecule techniques with high resolution and efficiency.Lay DescriptionParticles are widely used as probes in life sciences through their motions. In single molecule techniques such as optical tweezers and magnetic tweezers, microbeads are used to study intermolecular or intramolecular interactions via beads tracking. Also tracking multiple beads’ motions could study cell–cell or cell–ECM interactions in traction force microscopy. Therefore, particle tracking is of key important during these researches. However, parallel 3D multiple particle tracking in real‐time with high resolution is a challenge either due to the algorithm or the program. Here, we combine the performance of CPU and CUDA‐based GPU to make a hybrid implementation for particle tracking. In this way, a speedup of 137 is obtained compared the program before only with CPU without loss of accuracy. Moreover, we improve and build a new centrifugal force microscope for multiple single molecule force spectroscopy research in parallel. Then we employed our program into centrifugal force microscope for DNA stretching study. Our results not only demonstrate the application of this program in single molecule techniques, also indicate the capability of multiple single molecule study with centrifugal force microscopy.
“It's Beautiful to be Old.” In Search of Emergent Catholic Social Teaching on Old Age
Authors: Kevern Peter 
Published: November 2018

AbstractThe proportion of older people in the population is rapidly increasing, both nationally and globally. This demographic shift poses some pressing practical challenges for governments as they seek to provide care for an ageing population; but in addition, it raises sociocultural and theological questions about how the role and significance of older people is understood in contemporary developed economies. In response to these challenges, the present paper attempts to identify the outlines of an emerging Catholic Social Teaching on old age in the encyclicals and words of the last three popes. Two key themes are identified which inform a distinctive Catholic perspective on old age. These are the continuing pilgrimage, role and contribution of older people to the end of life on the one hand, and their challenge to the values of a ‘throwaway culture’ on the other. The foundational significance of these themes for an emerging Catholic witness form the basis for the concluding recommendations.
Time in Heaven: From Glory to Glory
Authors: Steinkerchner Scott 
Published: November 2018

AbstractThis article addresses three questions: Is there time in heaven? If so, what is it like? and How does it relate to time in this universe? In dialogue with modern science, this paper argues that since Christianity believes in the resurrection of the body and life everlasting, it should also affirm that there is time and space in heaven. Thus, rather than picturing heaven as a changeless, eternal moment, it is better to picture is as an everlasting experience of advancing from glory to glory. The time and the space in heaven is not the same as the time and the space in this universe, but the relationship between spacetime in heaven and spacetime in this universe in shrouded in mystery. While in this universe time always advances in one direction, in heaven, we might be able to move both forwards and backwards in time, though always moving forward in glory. It is also possible that the saints in heaven could revisit different times on earth, making for a complex interaction between heavenly and earthly timelines that could explain how the saints in heaven can hear and respond to earthly prayers.
Estimation of treatment effects for heterogeneous matched‐pairs data with probit models
Authors: Wang Jun , Gao Wei , Tang Man‐Lai 
Published: November 2018

AbstractEstimating the effect of medical treatments on subject responses is one of the crucial problems in medical research. Matched‐pairs designs are commonly implemented in the field of medical research to eliminate confounding and improve efficiency. In this article, new estimators of treatment effects for heterogeneous matched‐pairs data are proposed. Asymptotic properties of the proposed estimators are derived. Simulation studies show that the proposed estimators have some advantages over the famous Heckman's estimator, the conditional maximum likelihood estimator, and the inverse probability weighted estimator. We apply the proposed methodology to a data set from a study of low‐birth‐weight infants.
Lethality of Previous Suicidal Behavior among Patients Hospitalized for Suicide Risk Predicts Lethality of Future Suicide Attempts
Authors: Rojas Sasha M. , Skinner Kayla D. , Feldner Matthew T. , Rodante Demian E. , Puppo Soledad , Vidjen Patricia , Portela Alicia , Grendas Leandro N. , Daray Federico M. 
Published: November 2018

ObjectiveA suicide attempt is an established risk factor for subsequent suicide attempts and suicide. Nonetheless, the prediction of future suicidal behavior is poor. The lethality of previous suicidal behavior may be informative to better understand future suicide risk among patients hospitalized for suicidal thoughts and behavior. The current study examined whether the lethality of patients' index (most recent suicidal episode at hospitalization), first, and worst suicidal episode predicts the lethality of one's most lethal suicide attempt during a 2‐year follow‐up period.MethodA total of 98 patients hospitalized at an emergency department for high suicide risk (i.e., acute suicidal ideation or a suicide attempt) were included in the study.ResultsResults indicated that the lethality of the index suicidal episode predicted the lethality of the worst suicide attempt during a 2‐year follow‐up period.ConclusionsThese findings extend a growing literature examining risk factors that influence the progression toward high lethality suicidal behavior.
Neonatal alloimmune thrombocytopenia due to a new alloantigen Bl(a) defined by an Asp458Gly substitution in GPIIIa
Authors: Poles Anthony , Lucas Geoff , Green Frances , Walser Piers , Davey Sue , Ridgwell Kay , Wylie Philip 
Published: November 2018

BACKGROUNDNeonatal alloimmune thrombocytopenia (NAIT) commonly arises due to antibodies against a small number of well‐defined human platelet antigens (HPAs). A minority of NAIT cases occur due to maternal immunization against low‐frequency polymorphisms in platelet glycoprotein that result in new immunogenic epitopes. Antibodies to these novel epitopes can be detected by the incubation of maternal serum with paternal platelets and is usually performed after initial investigation using HPA‐typed panel platelets has failed to provide evidence of NAIT.STUDY DESIGN AND METHODSThe propositus and the parents from a case of suspected neonatal alloimmune thrombocytopenia (NAIT) were investigated using serologic and molecular techniques to detect and identify relevant platelet‐specific antibodies and for HPA typing. Calculations of molecular dynamics were undertaken to explore potential variations in the molecular structure.RESULTSMaternal antibodies were detected that were reactive only in crossmatch with paternal platelets using the platelet immunofluorescence test (PIFT) and a GPIIb/IIIa monoclonal antibody immobilization of platelet antigen (MAIPA) assay. In the propositus and father, a novel mutation c.1373 A > G was found in exon 10 of ITGB3 resulting in the substitution of an aspartic acid for a glycine (p.Asp458Gly). Recombinant GPIIIa glycoprotein mutated to contain the novel mutation and expressed in HEK293 cells with GPIIb was also specifically recognized by maternal antibodies. Calculations of molecular dynamics identified that the mutation was in a structurally constrained site.CONCLUSIONThis case describes a low‐frequency platelet antigen (Asp458Gly) that defines a further alloantigenic target in NAIT. The case emphasizes the role of the platelet crossmatch as the single most useful tool to establish evidence of immunization of low‐frequency platelet glycoprotein polymorphisms. A crossmatch should always be performed where there is strong clinical evidence of NAIT but initial laboratory investigations are not confirmatory.
Morphological and molecular characterisation of Moshajia idiofora Siddiqi, 1982 (Dorylaimida: Qudsianematidae), with new insights into the phylogeny of the enigmatic Lordellonematinae
Authors: Imran Zarrin , Abolafia Joaquín , Peña-Santiago Reyes , Ahmad Wasim 
Published: November 2018

Summary
Seven populations of Moshajia idiofora, six from India and one from Japan, are characterised, including morphological description, morphometrics, LM and SEM observations, and molecular (18S rDNA gene sequence) analysis. These populations are compared to previous records of the species as well as its closest species. Two of these species, M. cultristyla and M. qasimi, are regarded as junior synonyms of M. idiofora. SEM pictures provide new details of the lip region form. Molecular data indicate that M. idiofora belongs to a morphologically heterogeneous clade whose components share the absence of a distinctly developed pars refringens vaginae and raise a serious doubt about the traditional position of Lordellonematinae representatives in the Dorylaimina system.
Human Rights Protection and Traditional Churches in the System of National Cooperation in Hungary
Authors: Mink Júlia 
Published: November 2018

Abstract
Hungary adopted its new Fundamental Law and new legislative framework on the legal status of churches, religious denominations and religious communities in 2011, as part of a number of constitutional changes leading to the dismantlement of democracy, rule of law and human rights protection. In relation to the new legislative framework of state-church relations, much assessment so far focused on how the installment of a “pluralist system of state churches” led to an institutional and partly moral establishment, jeopardizing and curtailing the religious freedom of non-established religious denominations. However, it has been less investigated how the “pluralist system of state churches” and related constitutional changes affected a number of human rights (e.g. the right to private and family life or the right to education) and the position of traditional churches, especially, in view of their autonomy. The paper intends to show that the close entanglement of the state and its traditional churches led to the deterioration of the protection of a number of human rights while it also undermined the autonomy of these churches.
Quaker Studies: An Overview
Authors: Daniels C. Wess , Healey Robynne Rogers , Kershner Jon R. , Angell Stephen W. , Dandelion Pink 
Published: November 2018

AbstractIn this introductory volume to Brill’s series on Quaker Studies, Quaker Studies, An Overview: The Current State of the Field, C. Wess Daniels, Robynne Rogers Healey, and Jon Kershner investigate Quaker Studies, divided into the three fields of history, theology and philosophy, and sociology.With a focus on schisms, transatlantic networks, colonialism, abolition, gender and equality, and pacifism from Quaker origins onward, Healey explores the rich diversity and complexity of research and interpretation that has emerged in Quaker history.In his chapter, Kershner explores comparisons and divergences in contemporary Quaker theology and philosophy. Special attention is paid to Quaker biblical hermeneutics, mysticism, ethics, epistemology and Global Quakerism.Daniels looks at the sociology of Quakerism as a new field of study that has only recently begun to be explored and developed. This chapter surveys the field of sociological work done within Quakerism from the 1960s to the present day.
Enriched environment on the intestinal mucosal barrier and brain–gut axis in rats with colorectal cancer
Authors: Liu Dun , Jiang Xiao-Ying , Zhou Lan-Shu 
Published: November 2018

An enriched environment (EE) is an animal housing technique in which animals are given increased amounts of space, physical activity, and social interaction. Currently, researchers studying EE focus mainly on its effects within the context of neurological diseases. However, little is known about how EE affects the intestinal mucosal barrier. This study assessed the effects of EE on the intestinal mucosal barrier in rats with colorectal cancer. A rat model of 1,2-dimethylhydrazine (DMH)-induced colorectal cancer was used. The rats were housed in eight conditions for eight weeks: EE, large cages containing eight rats with stimulating objects; enlarged space and socially enriched conditions (ES), large cages containing eight rats; enlarged space and cognition enriched conditions (EC), large cages containing one rat with stimulating objects; enlarged space enriched conditions (E), large cages containing one rat; cognition and socially enriched conditions (CS), four to five rats housed in standard cages containing stimulating objects; cognition enriched conditions (C), rats housed individually in small-size cages containing stimulating objects; socially enriched conditions (S), standard cages containing four rats; and normal conditions (blank group, B). We determined the weight of each rat, measured the intestinal mucosa and plasma levels of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), interleukin 10 (IL-10), ghrelin, corticotropin-releasing factor (CRF), occludin, bacterial translocation (BT), and secretory immunoglobulin A (SIgA), and assessed the morphology of the intestinal mucosa. On the whole, the combination of cognitive stimulus and social support was better than the combination of three factors in maintenance of the intestinal mucosal immune barrier and brain–gut peptide. The combination of all three factors and combination of cognitive training and social support were more effective than any single factor. Future studies are needed to study the effects of an EE on body weight, brain–gut peptide, and the intestinal mucosa biological barrier. Impact statement An enriched environment (EE) is an animal housing technique where animals are given increased amounts of space, physical activity, and social interaction. Presently, researchers studying EEs focus mainly on their effects within the context of neurological diseases. However, little is known about how EEs affect the intestinal mucosal barrier. This study assessed the effects of an EE on the intestinal mucosal barrier in rats with colorectal cancer.
Patterns of Opioid Prescription, Use, and Costs Among Patients With Advanced Cancer and Inpatient Palliative Care Between 2008 and 2014
Authors: Yennurajalingam Sriram , Lu Zhanni , Reddy Suresh K. , Rodriguez EdenMae C. , Nguyen Kristy , Waletich-Flemming Marie J. , Lim Kyu-Hyoung , Memon Aksha , Nguyen Nhu-Nhu , Rofheart Kristy W. , Wang Guoqin , Barla Srikanth Reddy , Wu Jimin , Williams Janet L. , Bruera Eduardo 
Published: November 2018

PURPOSE: An understanding of opioid prescription and cost patterns is important to optimize pain management for patients with advanced cancer. This study aimed to determine opioid prescription and cost patterns and to identify opioid prescription predictors in patients with advanced cancer who received inpatient palliative care (IPC). MATERIALS AND METHODS: We reviewed data from 807 consecutive patients with cancer who received IPC in each October from 2008 through 2014. Patient characteristics; opioid types; morphine equivalent daily dose (MEDD) in milligrams per day of scheduled opioids before, during, and after hospitalization; and in-admission opioid cost per patient were assessed. We determined symptom changes between baseline and follow-up palliative care visits and the in-admission opioid prescription predictors. RESULTS: A total of 714 (88%) of the 807 patients were evaluable. The median MEDD per patient decreased from 150 mg/d in 2008 to 83 mg/d in 2014 ( P < .001). The median opioid cost per patient decreased and then increased from $22.97 to $40.35 over the 7 years ( P = .03). The median MEDDs increased from IPC to discharge by 67% ( P < .001). The median Edmonton Symptom Assessment Scale pain improvement at follow-up was 1 ( P < .001). Younger patients with advanced cancer (odds ratio [OR[, 0.95; P < . 001) were prescribed higher preadmission MEDDs (OR, 1.01; P < .001) more often in the earlier study years (2014 v 2009: OR, 0.18 [ P = .004] v 0.30 [ P = .02]) and tended to use high MEDDs (> 75 mg/d) during hospitalization. CONCLUSION: The MEDD per person decreased from 2008 to 2014. The opioid cost per patient decreased from 2008 to 2011 and then increased from 2012 to 2014. Age, prescription year, and preadmission opioid doses were significantly associated with opioid doses prescribed to patients with advanced cancer who received IPC.
Attitudes of women in Cambodia towards child physical abuse
Authors: Dalal Koustuv , Parvin Nuri Reshma , Shinn Lee, Ming , Kuang Lin Chao , Gifford Mervyn , Ussatayeva Gainel , Biswas Animesh 
Published: November 2018

Background: This study attempted to explore the women’s attitude towards child physical abuse in relation to the respondent’s background factors, personal issues and autonomy. Methods: This was a cross-sectional study of 18,749 women of reproductive age (15-49 years) using 2010 Cambodia Demographic and Health Survey. Chi-square tests and bivariate analyses were performed. Results: A significant proportion of women supported beating physically abusing sons (69.2%) and daughters (67.2%). Rural, non-Buddhist, those with no or primary education, poverty, seasonal or occasional employment seem to be risk factor for supporting child physical abuse by women (in bivariate analysis). Age, education and household economic status of the women are significantly relevant for child physical abuse (in bivariate analysis). Women who came from male-headed households more often supported beating their children. Female autonomy is an important factor for child physical abuse. Women who justify physical abuse towards wives were also generally supportive of child physical abuse. Conclusions: The current study provides knowledge about maternal factors such as age, education, economic status, rural/urban dwelling, two or more lifetime partners and autonomy in the supporting of beating sons and daughters. Further attention needs to be paid to increasing women’s education and autonomy in Cambodian family life.