bluuebunny/crossref_metadata_2025_split huggingface dataset:
Camouflaging Structural Diversity: Co‐crystallization of Two Different Nanoparticles Having Different Cores But the Same Shell
Authors: Bodiuzzaman Mohammad , Ghosh Atanu , Sugi Korath Shivan , Nag Abhijit , Khatun Esma , Varghese Babu , Paramasivam Ganesan , Antharjanam Sudhadevi , Natarajan Ganapati , Pradeep Thalappil 
Published: November 2018

AbstractTwo ligand‐protected nanoscale silver moieties, [Ag46(SPhMe2)24(PPh3)8](NO3)2 and [Ag40(SPhMe2)24(PPh3)8](NO3)2 (abbreviated as Ag46 and Ag40, respectively) with almost the same shell but different cores were synthesized simultaneously. As their external structures are identical, the clusters were not distinguishable and become co‐crystallized. The occupancy of each cluster was 50 %. The outer shell of both is composed of Ag32S24P8, which is reminiscent of fullerenes, and it encapsulates a well‐studied core, Ag14 and a completely new core, Ag8, which correspond to a face‐centered cube and a simple cube, respectively, resulting in the Ag46 and Ag40 clusters. The presence of two entities (Ag40 and Ag46 clusters) in a single crystal and their molecular formulae were confirmed by detailed electrospray ionization mass spectrometry. The optical spectrum of the mixture showed unique features which were in good agreement with the results from time‐dependent density functional theory (TD‐DFT).
Evidence of Phosphonium‐Carbenium Dication Formation in a Superacid: Precursor to Fluorinated Phosphine Oxides
Authors: Castelli Ugo , Lohier Jean‐François , Drukenmüller Ines , Mingot Agnès , Bachman Christian , Alayrac Carole , Marrot Jérôme , Stierstorfer Karin , Kornath Andreas , Gaumont Annie‐Claude , Thibaudeau Sébastien 
Published: November 2018

AbstractUnambiguously confirmed by low‐temperature in situ NMR experiments, X‐ray diffraction and vibrational spectroscopy, phosphonium‐carbenium superelectrophiles are shown to be generated in strong acidic conditions. Representing crucial intermediates, their exploitation allows for the synthesis of unprecedented fluorinated (cyclic) phosphine oxides.
Coiled‐Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection
Authors: Mueller Carolin , Grossmann Tom N. 
Published: November 2018

AbstractThe understanding of protein folding and assembly is of central importance for the design of proteins and enzymes with novel or improved functions. Minimalistic model systems, such as coiled‐coils, provide an excellent platform to improve this understanding and to construct novel molecular devices. Along those lines, we designed a conformational switch that is composed of two coiled‐coil forming peptides and a central binding epitope. In the absence of a binding partner, this switch adopts a hairpin‐like conformation that opens upon receptor binding. Variation of the coiled‐coil length modulates the strength of the intramolecular constraint. The two conformational states of this switch have been linked with characteristic fluorescent properties, which enables the detection of the receptor in real‐time.
A Dy4 Cubane: A New Member in the Single‐Molecule Toroics Family
Authors: Fernandez Garcia Guglielmo , Guettas Djamila , Montigaud Vincent , Larini Paolo , Sessoli Roberta , Totti Federico , Cador Olivier , Pilet Guillaume , Le Guennic Boris 
Published: November 2018

AbstractMolecular materials that possess a toroidal moment associated to a non‐magnetic ground state are known as single‐molecule toroics (SMTs) and are usually planar molecules. Herein, we report a Dy4 cubane, namely [Dy4(Bppd)4(μ3‐OH)4(Pa)4(H2O)4]⋅0.333 H2O (where BppdH=1,3‐Bis(pyridin‐4‐yl)propane‐1,3‐dione and PaH=2‐Picolinic acid) for which magnetometry measurements and state‐of‐art ab initio calculations highlight SMT behavior in a tridimensional structure (3D‐SMT). The in‐depth theoretical analysis on the resulting low‐lying energy states, along with their variation in function of the magnetic exchange pathways, allows further light to be shed on the description of single‐molecule toroics and identify the coupling scheme that better reproduces the observed data.
Facile Synthesis of Pyridines from Propargyl Amines: Concise Total Synthesis of Suaveoline Alkaloids
Authors: Zhao Zhiwen , Wei Hongbo , Xiao Ke , Cheng Bin , Zhai Hongbin , Li Yun 
Published: November 2018

AbstractA general and efficient protocol was developed for the synthesis of polysubstituted pyridines from propargyl amines and unsaturated carbonyl compounds through a tandem condensation/alkyne isomerization/6π 3‐azatriene electrocyclization sequence. This process was found to be applicable to a wide range of readily available substrates (30 examples, up to 95 % yield) and could be readily performed on a preparative (20 g) scale. By taking advantage of this method for late‐stage pyridine incorporation, we successfully completed the collective total synthesis of suveoline, norsuveoline, and macrophylline.
A Novel Understanding of Phocidae Hearing Adaptations Through a Study of Northern Elephant Seal (Mirounga angustirostris) Ear Anatomy and Histology
Authors: Smodlaka Hrvoje , Khamas Wael A. , Jungers Hali , Pan Roman , Al‐Tikriti Mohammed , Borovac Josip A. , Palmer Lauren , Bukac Martina 
Published: November 2018

ABSTRACTThe most conspicuous aural adaptation in northern elephant seals (NES) is complete absence of an auricle and a tortuous collapsed external acoustic meatus. The NES epitympanic recess contains massive ossicles immersed in the middle ear cavernous sinuses. Engorgement of the cavernous sinuses would make ossicles fully buoyant during deep diving. NES have a comparatively larger cochlear nerve, which carries a significantly larger number of axons than in terrestrial mammals, which would give them auditory ability similar to the obligate marine mammals such as cetaceans. Our calculations show that the traditional “air‐dependent” impedance matching mechanism in NES functions to just half of the capacity compared with the one described in terrestrial mammals. Impedance matching would be further hindered in NES while diving due to fully collapsed external acoustic meatus. Thanks to similarities of acoustic impedance between the sea water, soft tissues, and blood sinuses, very little sound energy would be reflected and lost. When sound is generated underwater, the large ossicles, buoyant in the cavernous sinus, would not move due to oscillation of tympanic membrane. Rather, they would be oscillating due to their inertia and process of acoustic streaming. Our mathematical simulation shows that an increase in sound frequency would cause increased displacement of the stapedial footplate and thus transmit the sound energy to the inner ear. We contend that during diving, impedance matching and sound signal amplification in the middle ear courses through the cavernous sinuses and oscillates the enlarged ossicles, thus enabling a high‐frequency ultrasonic hearing range in Phocidae. Anat Rec, 302:1605–1614, 2019. © 2018 American Association for Anatomy
Carbonstäbe im Bauwesen
Authors: Schumann Alexander , May Maximilian , Curbach Manfred 
Published: November 2018

AbstractIm Bauwesen findet die Verwendung von Faserverbundkunststoffen (FVK) immer mehr Anwendung. Im Speziellen werden Bewehrungsstäbe aus Carbonfasern vermehrt im Bauwesen eingesetzt, da diese resistent gegenüber Korrosion sind und für den Anwendungsfall sehr gute mechanische Eigenschaften aufweisen. Jedoch müssen bei der Verwendung von Carbonstäben wesentliche Eigenschaften beachtet werden, um sie effizient und ihrem hohen Leistungspotenzial entsprechend einzusetzen. Nach einem geschichtlichen Überblick zur Verwendung von FVK‐Stäben im Bauwesen werden in diesem Beitrag wesentliche mechanische Merkmale und grundlegende Mechanismen von Carbonstäben vorgestellt. Zusätzlich erfolgt ein Ausblick auf das Zug‐ und Verbundtragverhalten von Carbonstäben.In geplanten Folgebeiträgen wird aufbauend auf den hier vorgestellten grundlegenden Informationen ausführlich auf das Zug‐ und Verbundtragverhalten von Carbonstäben eingegangen.
Optimal promising zone designs
Authors: Hsiao Samuel T. , Liu Lingyun , Mehta Cyrus R. 
Published: November 2018

AbstractClinical trials with adaptive sample size reassessment based on an unblinded analysis of interim results are perhaps the most popular class of adaptive designs (see Elsäßer et al., 2007). Such trials are typically designed by prespecifying a zone for the interim test statistic, termed the promising zone, along with a decision rule for increasing the sample size within that zone. Mehta and Pocock (2011) provided some examples of promising zone designs and discussed several procedures for controlling their type‐1 error. They did not, however, address how to choose the promising zone or the corresponding sample size reassessment rule, and proposed instead that the operating characteristics of alternative promising zone designs could be compared by simulation. Jennison and Turnbull (2015) developed an approach based on maximizing expected utility whereby one could evaluate alternative promising zone designs relative to a gold‐standard optimal design. In this paper, we show how, by eliciting a few preferences from the trial sponsor, one can construct promising zone designs that are both intuitive and achieve the Jennison and Turnbull (2015) gold‐standard for optimality.
Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice
Authors: Xu Zheng , Wang Can , Dong Xiaoguang , Hu Tao , Wang Lingling , Zhao Wenbo , Zhu Shaowei , Li Guibao , Hu Yanlai , Gao Qing , Wan Jiale , Liu Zengxun , Sun Jinhao 
Published: November 2018

AbstractAlcohol addiction can cause brain dysfunction and many other diseases. Recently, increasing evidences have suggested that gut microbiota plays a vital role in regulating alcohol addiction. However, the exact mechanism has not yet been elucidated. Here, our study focused on the intestinal bacteria alternations and their correlations with alcohol‐induced neuropsychic behaviors. When consuming alcohol over 3‐week period, animals gradually displayed anxiety/depression‐like behaviors. Moreover, 16S rRNA sequencing showed significant intestinal microflora dysbiosis and distinct community composition. Actinobacteria and Cyanobacteria were both increased at the phylum level. At the genus level, Adlercreutzia spp., Allobaculum spp., and Turicibacter spp. were increased whereas Helicobacter spp. was decreased. We also found that the distances in inner zone measured by open field test and 4% (v/v) alcohol preference percentages were significantly correlated with Adlercreutzia spp. The possible mechanisms were explored and we found the expression of brain‐derived neurotrophic factor (BDNF) and α1 subunit of γ‐aminobutyric acid A receptor (Gabra1) were both decreased in prefrontal cortex (PFC). Especially, further correlation analyses demonstrated that decreased Adlercreutzia spp. was positively correlated with alcohol preference and negatively correlated with anxiety‐like behavior and BDNF/Gabra1 changes in PFC. Similar relationships were observed between Allobaculum spp. and alcohol preference and BDNF changes. Helicobacter spp. and Turicibacter spp. were also correlated with PFC BDNF and hippocampus Gabra1 level. Taken together, our study showed that gut microbiota dysbiosis during chronic alcohol exposure was closely correlated with alcohol‐induced neuropsychic behaviors and BDNF/Gabra1 expression, which provides a new perspective for understanding underlying mechanisms in alcohol addiction. © 2018 BioFactors, 45(2):187–199, 2019
(Un) doing gender for achieving equality at work: The role of corporate social responsibility
Authors: Torres Luis D. , Jain Aditya , Leka Stavroula 
Published: November 2018

AbstractCorporate social responsibility (CSR) research has been largely interested in answering the question of why more women at work is good for business, leaving unattended the question of how to achieve this, and how feminist theories can be integrated with this purpose. This paper puts forward some conceptual propositions for advancing these questions by examining the linkages between the doing and undoing gender concepts from the feminist organization studies, and the role of CSR. The paper follows a conceptual approach to develop and support propositions. We propose that gender strategies will vary in organizations according to what CSR orientation they assume (compliance or proactive CSR), and how they navigate the un/doing gender continuum. By doing so, a two‐axis model is portrayed and four specific gender strategies identified. The model can support research aiming at exploring how CSR can be a tool for achieving gender equality at work, and managers looking at implementing or evaluating their gender responsible strategies.
Can interfirm trust improve firms' cooperation on environmental innovation? The moderating role of environmental hostility
Authors: Liao Zhongju , Long Siying 
Published: November 2018

AbstractBased on the logic of “trust‐behavior,” we examined the relationship between interfirm cognitive trust, emotional trust, and firms' cooperation on environmental innovation, as well as the moderating role of environmental hostility on the relationship between two dimensions of interfirm trust and cooperation on environmental innovation. Data for the study were collected from 216 firms in China. The results indicated that both interfirm cognitive trust and emotional trust were positively correlated to firms' cooperation on environmental innovation, and the effect of emotional trust on firms' cooperation on environmental innovation was negatively moderated by environmental hostility. Finally, the results were discussed and future directions put forward.
Chemical Constituents from Tabernaemontana bufalinaLour.
Authors: Xu Jian , Qu Wei , Cao Wen‐Yuan , Wang Yue , Zheng Kai‐Jun , Luo Shi‐Zheng , Wu Meng‐Yuan , Liu Wen‐Yuan , Feng Feng , Zhang Jie 
Published: November 2018

AbstractInvestigation of the branches and leaves of Tabernaemontana bufalina Lour. led to afford an undescribed monoterpenoid indole alkaloid, namely (3R,7S,14R,19S,20R)‐19‐hydroxypseudovincadifformine (1), and nine known metabolites (2–10). Their structures were determined by analysis of their NMR and ESI‐MS spectra, and modified Mosher's and calculated electronic circular dichroism (ECD) methods were used for establishing the absolute configuration of compound 1. Their cytotoxic activities were assayed using two cancer cell lines. As the results, cytotoxic activities on MDA‐MB‐231 and B16 cells showed IC50 values of 8.9 and 0.13 μm for 6, and of 20.3 and 11.7 μm for 9, respectively.
Feasibility, safety and midterm follow‐up of patients after nonsurgical closure of atrial septal defects using very large 40–46 mm nitinol septal occluders
Authors: Sivakumar Kothandam , Viswambaran Bijesh , Bhattacharjya Sudipta 
Published: November 2018

AbstractObjectivesTo study the feasibility of closure of large atrial septal defects (ASDs) using occluder devices >38 mm and assess the midterm complications.BackgroundFeasibility and safety of large occluders >38 mm and their follow‐up are largely unknown.MethodsAll patients with ASDs closed using devices >38 mm were retrospectively analyzed. Since outcome of patients receiving 40 mm devices were known before, patients receiving 40 mm devices were compared with those receiving 42–46 mm devices on demographic, hemodynamic parameters and procedural characteristics.ResultsA total of 17 patients with 40‐mm device and 31 patients with >40‐mm device formed the cohort. The mean echocardiographic defect size was 36.3 ± 3.7 mm. In total 19 patients had deficient retroaortic margin; inferior margin was deficient in one. Larger defects needed special deployment techniques more often. There was acute technical success in all patients. Two procedures failed; one device embolization next day in a patient with deficient inferior margin needed surgery. Another elderly patient with restrictive left ventricular physiology died of multiorgan dysfunction. Two late deaths on follow‐up were unrelated to the procedure. All other patients had symptom improvement. There were no erosions, thromboembolism or valvar regurgitation at a median follow‐up of 39 (1–60) months. Apart from late‐onset atrial flutter in one, there were no arrhythmias on follow‐up.ConclusionsOccluders larger than 38 mm in appropriately selected patients are feasible, successful and safe in majority and often require special deployment techniques. Complications during and after the procedure were infrequent. Very large defects with any deficient margin except retroaortic rim should be excluded from device closure.
Implantation of the Melody transcatheter pulmonary valve PB1016 in patients with dysfunctional right ventricular outflow tract conduits
Authors: Morray Brian H. , Jones Thomas K. , Coe James Y. , Gitter Roland , Martinez Jose Zunzunegui , Turner Daniel R. , Gray Robert G. , Lung Te‐Hsin , Berman Darren P. , Levi Daniel S. 
Published: November 2018

AbstractObjectivesThis study describes procedural and 1‐year outcomes of the 16 mm Melody PB1016 valve in patients with dysfunctional RVOT conduits.BackgroundThe Melody PB1016 is a standard Melody valve produced from a 16 mm bovine jugular vein and is intended for deployment up to 20 mm.MethodsThis is a prospective, non‐randomized, multicenter study of the procedural and short‐term outcomes of Melody PB1016 TPV replacement within dysfunctional RVOT conduits. Data from eight centers were included in the analysis.ResultsDuring the study period, 39 patients underwent attempted Melody TPVR. Of the 39 patients, 30 underwent successful Melody TPVR. The majority of patients underwent placement of one or more stents prior to TPVR. There was a significant reduction in peak conduit pressure gradient following TPVR (38 mmHg vs. 11 mmHg, P < 0.001). There were three cases of confined conduit tears successfully treated with covered stents or the valve itself. Repeat catheterization was performed in one patient for early re‐obstruction that was successfully treated with balloon valvuloplasty. At recent follow‐up, there were no cases of more than mild valve regurgitation and the mean pulmonary valve gradient by echocardiogram remained reduced relative to pre‐TPVR implant measurements (33.5 mmHg vs. 15.2 mmHg). There were no cases of valve stent fracture or endocarditis reported at the 1‐year follow‐up.ConclusionsOur analysis of TPVR with the PB1016 valve in RVOT conduits showed it to be safe and effective and can be performed in a wide range of conduit sizes with preserved valve function.ClinicalTrials.gov Identifier: NCT02347189.
HgII‐Mediated TlI‐to‐TlIII Oxidation in Dynamic PbII/Tl Porphyrin Complexes
Authors: Le Gac Stéphane , Ndoyom Victoria , Fusaro Luca , Dorcet Vincent , Boitrel Bernard 
Published: November 2018

AbstractCompared with their purely organic counterparts, molecular switches that are based on metal ion translocations have been underexplored, and more particularly, it remains challenging to control the translocation of several particles in multisite receptors. Recently, bimetallic complexes that undergo double translocation processes have been developed with bis‐strapped porphyrin ligands. To implement a redox control for these systems, we have investigated the formation of heterobimetallic lead/thallium complexes, with thallium in the +I and +III oxidation states. Two different complexes were characterized: 1) a PbII/TlI complex, in which both metal ions interact with the N‐core on its different sides, and 2) a PbII/TlIII complex with TlIII selectively bound to the N‐core and PbII selectively bound to the strap opposite to TlIII. These two complexes undergo interconversion between their two degenerate forms (same coordination of the metal ions but on opposite sides) by different intra or intermolecular translocation pathways. In addition, conversion of the PbII/TlI complex into its PbII/TlIII counterpart was achieved by addition of a stoichiometric amount of HgII salt as a sacrificial electron acceptor. These results further contribute to the elaboration of devices that feature redox‐controlled compartmentalized double translocations.
The incidence of fatal breast cancer measures the increased effectiveness of therapy in women participating in mammography screening
Authors: Tabár László , Dean Peter B. , Chen Tony Hsiu‐Hsi , Yen Amy Ming‐Fang , Chen Sam Li‐Sheng , Fann Jean Ching‐Yuan , Chiu Sherry Yueh‐Hsia , Ku May Mei‐Sheng , Wu Wendy Yi‐Ying , Hsu Chen‐Yang , Chen Yu‐Ching , Beckmann Kerri , Smith Robert A. , Duffy Stephen W. 
Published: November 2018

AbstractBackgroundWomen and their health care providers need a reliable answer to this important question: If a woman chooses to participate in regular mammography screening, then how much will this choice improve her chances of avoiding a death from breast cancer compared with women who choose not to participate?MethodsTo answer this question, we used comprehensive registries for population, screening history, breast cancer incidence, and disease‐specific death data in a defined population in Dalarna County, Sweden. The annual incidence of breast cancer was calculated along with the annual incidence of breast cancers that were fatal within 10 and within 11 to 20 years of diagnosis among women aged 40 to 69 years who either did or did not participate in mammography screening during a 39‐year period (1977‐2015). For an additional comparison, corresponding data are presented from 19 years of the prescreening period (1958‐1976). All patients received stage‐specific therapy according to the latest national guidelines, irrespective of the mode of detection.ResultsThe benefit for women who chose to participate in an organized breast cancer screening program was a 60% lower risk of dying from breast cancer within 10 years after diagnosis (relative risk, 0.40; 95% confidence interval, 0.34‐0.48) and a 47% lower risk of dying from breast cancer within 20 years after diagnosis (relative risk, 0.53; 95% confidence interval, 0.44‐0.63) compared with the corresponding risks for nonparticipants.ConclusionsAlthough all patients with breast cancer stand to benefit from advances in breast cancer therapy, the current results demonstrate that women who have participated in mammography screening obtain a significantly greater benefit from the therapy available at the time of diagnosis than do those who have not participated.
Magnum opus of an efficient hospitality technique for load balancing in cloud environment
Authors: Sakthivelmurugan V. , Vimala R. , Aravind Britto K.R. 
Published: November 2018

SummaryThe load balancing approach in the cloud environment is an open issue in the recent days. It helps obtain better resource utilization in cloud environment. It also improves the performance of the system. A good load balancing algorithm in cloud ensures no under loading or over loading in a single host. This paper proposes an algorithm named Hospitality Load Balancing (HLB) algorithm, which aims to balance the load among virtual machines (VM) for increasing the performance and throughput. The proposed algorithm handles preemptive or nonpreemptive tasks, which may be independent. It helps to reduce make span and obtain low task migration. The HLB algorithm has been analyzed and compared with plenty of load balancing technique. An experimental result shows that it is an excellent and effective algorithm when compared with the existing load balancing algorithm. It also illustrates the performance of proposed load balancing scheme with analysis and proves that it attains low makespan and low task migration.