bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osseointegrated Percutaneous Prosthetic System for the Treatment of Patients With Transfemoral Amputation: A Prospective Five-year Follow-up of Patient-reported Outcomes and Complications
Authors: Brånemark Rickard P. , Hagberg Kerstin , Kulbacka-Ortiz Katarzyna , Berlin Örjan , Rydevik Björn 
Published: December 2018

Introduction:Direct skeletal attachment of prostheses has previously been shown to improve patient-reported outcome (PRO) measures of individuals with transfemoral amputation (TFA) at 2-year follow-up. This prospective study reports the outcomes at 5-year follow-up.Methods:A total of 51 patients (55 legs) with TFA were included in a prospective study. Complications, success rate, and PRO measures were followed for 5 years.Results:The cumulative fixture survival rate at 5 years was 92%, and the revision-free survival rate was 45%. Thirty-four patients had 70 superficial infections. Eleven patients had 14 deep infections. Fifteen patients had mechanical complications. Four fixtures were removed (ie, one deep infection and three loosening). PRO measures showed significant improvements including more use of the prosthesis, better mobility, fewer issues, and improved physical health-related quality of life (allP< 0.0001) compared with baseline.Conclusion:Individuals with TFA at 5-year follow-up had significant improvement in PRO measures, but increases in deep infections and mechanical complications are concerning.
SCORE Kardiyovasküler Risk Puanlama Sistemi ile Non-dipper Hipertansiyon Arasındaki İlişki
Authors: ÖKSÜZ Fatih , YAYLA Cagrı 
Published: December 2018

Amaç: Non-dipper kan basıncının (KB) uç organ hasarı ve
ölümcül - ölümcül olmayan kardiyovasküler hastalıklarla (KVH) anlamlı şekilde
ilişkili olduğu gösterilmiştir. Kardiyovasküler (KV) olay riskinde artış
bulunan bireylerde sistematik KV risk değerlendirmesi önerilir. SCORE risk
sistemi, ilk ölümcül aterosklerotik olayın 10 yıllık riskini değerlendirir. Bu
çalışmanın amacı hipertansiyon (HT)hastalarında non-dipper KB ile SCORE risk
sistemi arasındaki bir ilişki olup olmadığının araştırılmasıdır.

Yöntemler: Bu çalışma retrospektif bir çalışmadır ve
esansiyel HT tanısı konulan ardışık 213 hastayı içermektedir. Non-dipper ve
dipper hasta grupları 24 saatlik ambulatuar kan basıncı izlemine (AKBİ) göre belirlendi.
SCORE sistemine göre yaş, cinsiyet, sigara kullanımı, sistolik kan basıncı
(SKB) ve total kolesterol (TK) gibi risk faktörleri kullanılarak 10 yıllık
ölümcül KV olay riski hesaplandı.

Bulgular: Non-dipper HT hasta grubunda SCORE risk sistemi anlamlı olarak
yüksek saptandı (p=0.017). Ayrıca sigara içme alışkanlığı sıklığı ve TK
değerleri non-dipper
HT’li hasta grubunda anlamlı olarak daha yüksek saptandı. Diğer demografik,
klinik ve laboratuvar parametreler iki grup arasında benzerdi. SCORE risk oranı
ile gece sistolik ve diyastolik KB’leri arasında orta derecede olmasına rağmen
anlamlı pozitif korelasyon izlendi (r = 0.354, p &lt; 0.001; r = 0.339,
p&lt;0.001; sırasıyla)

Sonuç: Bu çalışmada ilk defa non-dipper HT ile SCORE risk
sistemi arasında önemli bir ilişki olduğu gösterilmiştir. SCORE risk sistemi
ile hesaplanan 10 yıllık fatal KV olay ihtimalinin non-dipper hasta grubunda daha yüksek
saptanması, esansiyel HT tanılı hastaların AKBİ ile takibinin önemini ortaya
çıkarmıştır.
From sexualized torture and gender-based torture to genderized torture: The urgent need for a conceptual evolution
Authors: Pérez-Sales Pau , Zraly Maggie 
Published: December 2018

Classical perspectives on sexualized torture are being increasingly challenged by contemporary debates informed by emerging claims (Mendez, 2016; Sáez, 2016; Sifris, 2014). Gender-based analysis based on feminist and other theoretical approaches is needed to adequately address these.
Arriving at a general framework for the reconceptualization of torture, and progressively widening the analytical scope of gender and torture, are priorities. Gender analyses of torture needs to encompass a broader range of phenomena, from rape and attacks on sexual integrity to any suffering inflicted on human beings that is intricately intertwined with gender (Jakobsen, 2014), including and not limited to discrimination against LGTBI persons,1 genital mutilation, and the restriction of any of the broad range of issues under the frame of reproductive freedom, such as abortion and involuntary sterilization.2
The push for a gender transformative rethinking of conceptual and analytical approaches to torture is accompanied by the need to develop specific tools to detect and assess sexual and gender-based torture (including the necessity for a reconsideration of gender perspectives on the Istanbul Protocol), to incorporate a feminist perspective in the rehabilitation of victims. This requires specific treatment approaches as well as holistic survivor-centered rehabilitation models that include access to high quality and comprehensive services. Services that support stigma reduction are particularly important.
Our own desk review on all papers published in Torture Journal since 2006 until 2018 showed a clear gender analysis gap: only 32% of papers included the word ‘gender’ and 38% the word ‘female’ in any part of the text. In 84% of the cases, these mentions simply indexed the presentation of data disaggregated by sex. Only 4% of all the papers published in the Journal attempted a gender analysis. To help address this gap, the Journal circulated a call for papers on gender and torture that aligned with research priorities identified in our Delphi study (Pérez-Sales, Witcombe, & Otero, 2017). The response to this call has been encouraging.
This issue features a collection of texts that highlight important aspects of sexualized and gender-based torture and provide reflections that contribute to framing the theoretical debate on the nature and scope of gender-based and genderized forms of torture. The Journal believes that even more research and reflection is necessary to adequately clarify and raise the terms of this debate and additional texts relevant to the topic are planned to appear in forthcoming issues. This current issue draws out key concepts that are important to making an impact, both on the debate and in practice.
Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Authors: Chimura Misato , Wang Xiaowen , Jhund Pardeep S. , Henderson Alasdair D. , Claggett Brian L. , Desai Akshay S. , Fonseca Cândida , Goncalvesova Eva , Katova Tzvetana , Mueller Katharina , Glasauer Andrea , Rohwedder Katja , Viswanathan Prabhakar , Nodari Savina , Lam Carolyn S. P. , Saldarriaga Clara Inés , Senni Michele , Sharma Kavita , Voors Adriaan A. , Zannad Faiez , Pitt Bertram , Vardeny Orly , Vaduganathan Muthiah , Solomon Scott D. , McMurray John J. V. 
Published: November 2024

ImportanceSex is associated with the clinical presentation, outcomes, and response to treatment in patients with heart failure (HF). However, little is known about the safety and efficacy of treatment with finerenone according to sex.ObjectiveTo estimate the efficacy and safety of finerenone compared with placebo in both women and men.Design, Setting, and ParticipantsPrespecified analyses were conducted in the phase 3 randomized clinical trial Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients with Heart Failure (FINEARTS-HF). The trial was conducted across 653 sites in 37 countries. Participants were adults aged 40 years and older with symptomatic HF and left ventricular ejection fraction (LVEF) of 40% or greater randomized between September 2020 and January 2023.InterventionFinerenone (titrated to 20 mg or 40 mg) or placebo.Main Outcomes and MeasuresThe primary outcome was a composite of cardiovascular death and total (first and recurrent) HF events (unplanned HF hospitalizations or urgent HF visits).ResultsA total of 6001 patients were randomized in FINEARTS-HF, of whom 2732 were women (45.5%), with a mean (SD) age of 73.6 (9.1) years. Women had higher rates of any obesity, higher LVEF (54.6 [7.6%] vs 50.9 [7.6] for men), lower mean (SD) estimated glomerular filtration rate than men (59.7 [19.1] vs 64.1 [20.0] for men; P&amp;lt;.001) , worse New York Heart Association functional class, and lower Kansas City Cardiomyopathy Questionnaire-Total Symptom Scores (KCCQ-TSS) (mean [SD] 62.3 [24.0] vs 71.0 [23.1]). The incident rate of the primary outcome was slightly lower in women (15.7; 95% CI, 14.3-17.3) than in men (16.8; 95% CI, 15.4-18.3) per 100 person-years. Compared with placebo, finerenone reduced the risk of the primary end point similarly in women and men: rate ratio 0.78 (95% CI, 0.65-0.95) in women and 0.88 (95% CI, 0.74-1.04) in men (P = .41 for interaction). Consistent effects were observed for the components of the primary outcome and all-cause mortality. The mean increase (improvement) in KCCQ-TSS from baseline to 12 months was greater with finerenone, regardless of sex (P = .73 for interaction). Finerenone had similar tolerability in women and men.Conclusions and RelevanceIn FINEARTS-HF, finerenone reduced the risk of the primary end point similarly in women and men with heart failure with mildly reduced or preserved ejection fraction. Finerenone had similar tolerability in women and men.Trial RegistrationClinicalTrials.gov Identifier: NCT04435626
Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting
Authors: Yang Ziang , Tiemuerniyazi Xieraili , Xu Fei , Wang Yang , Sun Yang , Yan Peng , Tian Liangxin , Han Chao , Zhang Yan , Pan Shiwei , Hu Zhan , Li Xi , Zhao Wei , Feng Wei 
Published: November 2024

ImportanceEfficient approaches to prevent postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) are still needed.ObjectiveTo investigate whether partial cardiac denervation, achieved by cutting off the ligament of Marshall (LOM) and resecting the fat pad along the Waterston groove, can reduce the risk of POAF following CABG.Design, Setting and ParticipantsThis single-center, randomized clinical trial enrolled adult patients scheduled for isolated CABG in China. Enrollment was from August 15, 2022, to December 13, 2023; follow-up visits were 30 days after discharge.InterventionsParticipants were randomized into the intervention group (CABG plus partial cardiac denervation) and the control group (CABG only) in a 1:1 pattern. All participants were continuously monitored for the incidence of POAF until day 6 after the operation.Main outcome and MeasuresThe primary end point was the incidence of POAF in 6 days, defined as a supraventricular arrhythmia lasting for more than 30 seconds.ResultsThe trial enrolled 430 patients (79 [18.4%] female; mean [SD] age, 61.9 [7.8] years). Compared with the control group, the 6-day incidence of POAF was significantly lower in the intervention group (18.1% vs 31.6%; P = .001; risk ratio, 0.57 [95% CI, 0.41-0.81]). To further support these results, a sensitivity analysis performed with Kaplan-Meier survival curves also showed a significant reduction in the occurrence of POAF in the intervention group (hazard ratio, 0.53 [95% CI, 0.36-0.79]; P = .002). Safety assessments showed no difference between the 2 groups, while postoperative medical cost was reduced in the intervention group.Conclusions and RelevanceThis randomized clinical trial found that partial cardiac denervation was an effective procedure to reduce the occurrence of POAF after isolated CABG without additional postoperative complications. These results suggest that partial cardiac denervation may be a good option for cardiac surgeons to consider for preventing POAF after CABG.Trial RegistrationClinicalTrials.gov Identifier: NCT05009914
Patient‐reported persistent lymphedema and peripheral neuropathy among long‐term breast cancer survivors in the Carolina Breast Cancer Study
Authors: Yarosh Rina A. , Nichols Hazel B. , Wang Qichen , Hirschey Rachel , Kent Erin E. , Carey Lisa A. , Hayes Sandra C. , Ogunleye Adeyemi A. , Troester Melissa A. , Butler Eboneé N. 
Published: November 2024

AbstractBackgroundImproved breast cancer treatment has lengthened survival but also has long‐term impacts. Lymphedema and peripheral neuropathy are treatment‐related sequelae that extend into survivorship. Co‐occurrence of these conditions may further impair functional well‐being. Few studies have estimated the burden of these conditions among diverse survivors.MethodsCarolina Breast Cancer Study Phase 3 enrolled survivors diagnosed between 2008 and 2013 in North Carolina. Black and younger women (aged <50 years at diagnosis) were oversampled. With the use of ≥10 years of follow‐up data, the prevalence of persistent lymphedema, peripheral neuropathy, and their co‐occurrence was assessed. Prevalence differences (PDs) and 95% confidence intervals (CIs) were assessed according to patient and disease characteristics.ResultsA total of 1688 survivors were included, with an average of 11.1 years (SD, 0.6) postdiagnosis. The prevalence of persistent lymphedema, peripheral neuropathy, and their co‐occurrence was 18.7%, 27.7%, and 8.8%, respectively. Lymphedema was higher among those receiving a mastectomy and with >5 lymph nodes removed, and peripheral neuropathy was higher among women treated with taxane‐based chemotherapy. Co‐occurrence was higher among women with >5 lymph nodes removed (vs. <5; PD, 5.4; 95% CI, 2.1 to 8.8) and those treated with taxane‐based chemotherapy (vs. no chemotherapy; PD, 6.8; 95% CI, 3.9 to 9.7). The burden of lymphedema (PD, 2.7; 95% CI, 0.9 to 6.3) and peripheral neuropathy (PD, 5.8; 95% CI, 1.7 to 9.9) was higher among Black than White women. The prevalence of lymphedema (PD, 1.8; 95% CI, −1.5 to 5.1) and peripheral neuropathy (PD, 4.6; 95% CI, 0.8 to 8.4) was elevated among younger compared to older women.ConclusionsLymphedema and peripheral neuropathy affect a substantial proportion of survivors. Interventions are needed to reduce this burden.
Enhancing Supercapacitor Performance of NiCoMn‐Layered Double Hydroxide with Ag–Citrate/Polyaniline Nanocomposites
Authors: Makda Ammar , Marwat Mohsin Ali , Mahmood Muhammad Hamza , Naeem Abdullah , Abdullah Syed Muhammad , Humayun Muhammad , Karim Muhammad Ramzan Abdul , Bououdina Mohamed , Khan Muhammad Zubair , Hanif Muhammad Bilal 
Published: November 2024

Layered double hydroxide (LDH) has a layered structure, which makes it a strong candidate for supercapacitors (SC) due to its high surface area. However, they suffer from low conductivity due to insufficient charge transfer across their layers. This research aims to overcome this obstacle by introducing conductive channels among the layers by the addition of Ag–citrate and polyaniline (PANI). Consequently, five electrodes (S1–5) were made from NiCoMn LDH (referred to as LDH henceforth) and 2:1 Ag–citrate and PANI composite (Ag/PANI) in different ratios and made into electrodes. Electrochemical analysis revealed successful improvement in the performance of LDH as the fraction of Ag/PANI increased until it equaled Ag/PANI where the highest specific capacitance of 617 F g−1 was obtained, which is 12% greater than the value for solely LDH electrode (550 F g−1). A device was fabricated with the best electrode (S3) and activated carbon electrode, which demonstrated energy densities and power densities of 41 WhKg−1 and 412.5 W Kg−1 and 14 WhKg−1and 8250 W Kg−1 at 0.5 and 10 A g−1 current densities, respectively. It also exhibited a capacitive retention of about 75% at 3000 galvanostatic charge–discharge cycles. These results encourage the use in of NiCoMn LDH, in a 1:1 ratio with Ag/PANI in SCs due to its remarkable performance.
A Tale of Two Storms: Inter‐Storm Variability of Stable Water Isotopes in a Solute Transport Model
Authors: Grande Emilio , Delgadillo Moreno Brenda K. , Moran Jean E. 
Published: November 2024

ABSTRACTStable isotopic methods in hydroclimate monitoring are powerful for improving water resources management, but applications are limited, especially in semi‐arid regions where such management is needed most. Here, we show that we can address shortcomings related to the lack of a seasonal signal using stable water isotopic signatures measured in precipitation over the East San Francisco Bay area, California, during two contrasting events sampled at more than 20 locations in the winter of 2023. The observed range in δ18O in the rain samples is similar for both storms. However, the distributions do not overlap—the mean air temperature and δ18O during Winter Storm Olive (February 2023) were 2°C and − 12‰, respectively, while a warm atmospheric river event (March 2023) had a mean temperature of 9°C and δ18O of −6‰, close to the long‐term average δ18O measured in local precipitation. The Winter Storm showed expected trends in δ18O related to geography (i.e., lower with greater distance inland and elevation), while the atmospheric river δ18O pattern was more spatially uniform. We use hydrometric data from a gaged watershed in the study area and isotopic signatures of rain sampled during the two storm events and apply a solute transport model (StorAge selection) with a travel‐time approach to examine predicted watershed responses and potential water tracing applications. In this virtual experiment, we find that event size exerts a strong control on the relative amounts of runoff versus pre‐event water in the stream, while uncertainty in stream hydrograph separation is related to the degree of contrast between precipitation/runoff and pre‐event water. Key to flood prediction, adaptation, and mitigation, especially in coastal urban areas, is knowledge of the contributing water sources and timing of stream flow. The strong contrast in stable isotopes between these two events, close in time and over the same area, illustrates the potential to use stable isotope signatures to track the transport and mixing of events through natural and engineered watersheds that are threatened by climate whiplash events.
Experiences of loneliness and social isolation among young people with chronic physical conditions: A thematic synthesis of qualitative studies
Authors: Miao Yifan , Jasim Nibras , Guha Chandana , Sluiter Amanda , Owen Katherine B. , Yudianto Benedicta , Lim Michelle H. , Smith Ben J. , Manera Karine 
Published: November 2024

AbstractIntroductionYoung people with chronic health conditions are among the most at risk of having poor social connections, however, little is known about their experiences of loneliness and social isolation. We aimed to describe the perspectives and experiences of loneliness and social isolation among young people with chronic physical conditions.MethodsWe searched MEDLINE, Embase, PsycINFO, CINAHL, and CENTRAL from inception to May 2023 for qualitative studies that described the perspectives of loneliness and social isolation in young people aged 10–24 years with chronic physical conditions. Findings from the included studies were analyzed using thematic synthesis.ResultsWe included 35 studies across 12 countries involving 723 participants (56% female). Most studies (63%) were conducted in young people with cancer. Four major themes were identified: suffering from repercussions of disease (struggling with body image and physical changes, intensified disconnection while hospitalized); hindering relationships with peers and friends (missing out on formative experiences, feeling stuck behind, restrictive parental attitudes); grappling with social exclusion (facing concerns alone, bullying and ostracism); seeking social support and self‐help (reliance on family, kindness and empathy from friends, developing rapport with healthcare professionals, discovering self in adversity).ConclusionsSymptoms, treatments, and hospitalizations limited young people's social participation and ability to maintain friendships, and this was compounded by social exclusion and bullying. Supportive friends, family, and healthcare professionals helped mitigate feelings of isolation. Interventions and strategies are needed to improve social support and foster meaningful connections. This can be achieved through education and awareness initiatives that promote inclusion in schools and the community, as well as efforts to enhance social support and continuity of care in hospitals.
The Value of Ultrasonography in the Diagnosis of Abdominal Pregnancy
Authors: Zhu Hongyan , Zong Zhen , Gao Feng 
Published: November 2024

ABSTRACTObjectivesAnalyze the clinical and ultrasound characteristics of 15 cases of abdominal pregnancy (AP) to improve the ultrasonography‐based diagnosis.MethodsA retrospective research of AP patients from 2010 to 2021 with pathology was performed, clinical and ultrasound characteristics were analyzed and summarized.ResultsFifteen cases of AP occurred in early pregnancy. Most cases of AP were implanted in the pelvic cavity, with a few on the greater omentum and diaphragm, etc. Eight cases showed mixed hyperechoic, four cases had gestational sacs, and three cases exhibited mixed hypoechoic.ConclusionCombined with the characteristics of AP, ultrasound can provide a valuable diagnosis.
Factors associated with the development of recurrent and contralateral Charcot neuroarthropathy in individuals with diabetes mellitus: A scoping review
Authors: Cheong Keet Yeng , Bergin Shan M. , Munteanu Shannon E. , Perrin Byron M. , Landorf Karl B. 
Published: November 2024

AbstractIntroductionCharcot neuroarthropathy (CN) can result in fractures and dislocations of the foot and ankle in individuals with diabetes and neuropathy, leading to ulceration, amputation and a poor quality of life. Additional episodes of acute CN can lead to extended periods of physical and psychosocial distress. The aim of this scoping review was to identify and synthesise the evidence relating to factors associated with the development of recurrent and contralateral Charcot neuroarthropathy (CN) in individuals with diabetes.MethodsA systematic search of four electronic databases was conducted from inception to February 06, 2023. All relevant study designs, except single case studies, that had been published in full in peer‐reviewed journals were included. Studies were excluded if they were not published in English and did not provide data on individuals with diabetes.ResultsThe search identified two studies that investigated factors associated with the development of recurrent CN, but none that related to the development of contralateral CN. Ten factors were investigated for association with recurrent CN development: age, body mass index, diabetes type and duration, glycated haemoglobin, anatomical site affected, duration of offloading applied to treat the primary CN episode, use of pharmacological intervention, severity of neuropathy, and skin temperature. However, no significant associations were reported.ConclusionsThere is an alarming lack of evidence‐based findings in this research area to guide practice. Clearly, more research in the form of rigorous prospective studies is urgently required to identify risk factors for the development of recurrent and contralateral CN in individuals with diabetes.