bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variasi Waktu Kualitas Air Pada Tambak Budidaya Udang Dengan Teknologi Integrated Multitrophic Aquaculture (IMTA)di Mamuju Sulawesi Barat
Authors: Sahrijanna Andi , Septiningsih Early 
Published: April 2019

Penelitian ini bertujuan untuk mengetahui variasi waktu kualitas air pada tambak budidaya udang dengan teknologi integrated multitrophic aquakulture (IMTA) yaitu udang vaname, nila,kekeranga dan rumput laut. Penelitian dilaksanakan di Kabupaten Mamuju Sulawesi Barat dengan menggunakan 2 petak tambak berukuran A. 3.675 m2 dan B. 5.250 m2 dengan perlakuan (A) udang vaname intensif, nila merah, kekerangan dan rumput laut (B) udang faname semi intensif, nila merah, kekerangan dan rumput laut . Pengamatan kualitas air diamati setiap 3 jam selama 24 jam yang meliputi kualitas fisika yang diamati secara in situ yaitu oksigen, suhu, salinitas dan pH. Hasil penelitian yang di peroleh rata-rata yaitu oksigen (4,6 mg/L), suhu ( 32,76 oC), salinitas (23,7 ppt) dan pH (8,7) dan kualitas kimia berupa amonia, nitrit, posfat, nitrat, bahan organik dan alkalinitas di analisis di laboratorium.
ANALISIS POPULASI BAKTERI PADA AIR ASAM TAMBANG DENGAN PERLAKUAN SEDIMEN MANGROVE
Authors: Fahruddin Fahruddin 
Published: April 2019

Limbah air asam tambang merupakan sumber pencemar pada lingkungan yang bisa mengganggu kehidupan berbagai organisme, dapat ditanggulangi secara biologis dengan memanfaatkan mikroba dari sedimen lahan basah. Penelitian ini bertujuan untuk mengetahui dinamika populasi mikroba pada air asam tambang dengan perlakuan sedimen mangrove, perhitungan total mikroba dengan metode standard plate count .Hasil pengamatan menunjukkan perlakuan sedimen mangrove meningkatkan pertumbuhan populasi mikroba pada hari ke-15 yaitu 3,5 x 106 sel/ml pada perlakuan I dan 1,53 x106 sel/ml pada hari ke-15 pada perlakuan II, sedangkan pada perlakuan III sebagai kontrol jumlah mikroba hanya 0,2 x 106 di awal inkubasi dan terus menurun hingga hari ke 25.Hasil isolasi mikroba dari sedimen mangrove, didapatkan 13 isolat yang berbeda berdasarkan ciri morfologi secara makroskopis meliputi warna, bentuk, tipe dan elevasi koloni.
Developmental Dysplasia of the Hip in Patients with Connective-Tissue Disorders
Authors: Kerrigan Alicia , Ayeni Olufemi R. , Kishta Waleed 
Published: April 2019

» There is a scarcity of literature on the management of hip dysplasia in patients with connective-tissue disorders, including Down syndrome, Marfan syndrome, Ehlers-Danlos syndrome, Larsen syndrome, and osteogenesis imperfecta.» These genetic conditions result in abnormal connective-tissue and ligamentous laxity, and they present a unique, more complex approach for the patient with developmental dysplasia of the hip.» These patients may present at all ages and functional levels on a spectrum of developmental dysplasia of the hip ranging from mild to severe.» Individualized treatment involves consideration of age, disease severity, comorbidities, and functional status.» Treating orthopaedic surgeons may be the first to identify an undiagnosed connective-tissue disorder, and prompt genetic referral is crucial.
The Flexion-Type Supracondylar Humeral Fracture in Children
Authors: Sharma Anmol 
Published: April 2019

» A flexion supracondylar fracture of the humerus is an uncommon fracture in children and accounts for only 1% to 10% of all supracondylar fractures.» The injury is caused by a direct fall on the point of the elbow, causing hyperflexion at the elbow, rather than by a fall on an outstretched hand, which is the mechanism in an extension-type fracture.» The ulnar nerve is at higher risk of injury in this fracture by the spike of the proximal fragment or by entrapment in the callus.» This fracture is inherently unstable, leading to difficulty in maintaining reduction intraoperatively and difficult Kirschner wiring in the extension position in which the reduction is achieved.» Kirschner wiring can be done in a flexed position of the elbow by utilizing a push-pull method, a temporary transolecranon pin, or a Kirschner wire as a joystick in the distal fragment to achieve and maintain reduction before the insertion of the final pins.
Effects of c-Src kinase on lens diseases associated with EMT of human lens epithelial cells
Authors: Li Xing-Yu , Wang Fang , Ren Mei-Xia , Du Min-Juan , Zhou Jian 
Published: April 2019

Abstract
Background

c-Src kinase regulated the signaling pathway of epithelial to mesenchymal transition (EMT) in many cells. The purpose of this study was to investigate the effects of c-Src kinase on EMT of human lens epithelial cells in vivo stimulated by different factors.

Methods

Human lens epithelial cells, HLE-B3 were exposure to inflammatory factors including IL-1α, IL-6, TNF-α, and IL-1β at 10 ng/mL, and high glucose (35.5 mM) respectively, for 30 mins. Activity of c-Src kinase was evaluated by expression of p-Src418 with western blot assay. To investigate activation of c-Src on EMT, HLE-B3 cells were transfected with pCDNA3.1-SrcY530F to up regulate c-Src, and pSlience4.1-ShSrc to knock down it. The expressions of c-Src kinase and molecular markers of EMT such as E-cadherin, ZO-1, α-SMA and vimentine were examined at 48 hours by RT-PCR and western blot. At 48 hours and 72 hours of transfection, cell proliferation was detected by MTT, cell mobility and migration were determined by scratch and transwell assay.

Results

Activity of c-Src kinase, expression of p-Src418 was upregulated by different inflammatory factors and high glucose in HLE-B3 cells. When HLE-B3 cells were transfected with pCDNA3.1-SrcY530F, the expression of c-Src kinase was upregulated on both mRNA and protein level, and activity of c-Src, p-Src418 increased. The expressions of E-cadherin and ZO-1 suppressed, while the expressions of vimentin and αSMA elevated on both mRNA and protein level at the same time. Cell proliferation, mobility and migration increased along with activation of c-Src kinase. Conversely, when HLE-B3 cells were transfected with pSlience4.1-ShSrc, both c-Src kinase and p-Src418 were knocked down. The expressions of E-cadherin and ZO-1 increased, but the expressions of vimentin and α-SMA decreased, meanwhile cell proliferation, mobility and migration reduced.

Conclusions

c-Src kinase in lens epithelial cells is easily activated by external stimuli, resulting in inducing of cell proliferation, mobility, migration and EMT.
Peripheral T cell lymphoma after chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A case report
Authors: Liu Xiao-hang , Jin Fan , Zhang Meng , Liu Mei-xi , Wang Tao , Pan Bo-ju , Zhang Lu 
Published: April 2019

Abstract
Background

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder in the central nervous system (CNS) with distinct clinical, radiological, and pathological characteristics. The pathophysiology of CLIPPERS still remains unclear. Because a few cases about lymphoma mimicking the manifestations of CLIPPERS were reported and the prognosis of lymphoma is much worse, early identification of lymphoma is very important.

Case presentation

A 31-year-old woman was admitted with 3 months’ history of diplopia, dizziness, gait ataxia and right facial numbness. The diagnosis of CLIPPERS was established based on the finding of punctate enhancing lesions in the cerebellum, thalamus, pons, medulla, and midbrain region in magnetic resonance imaging (MRI), together with the favorable clinical and radiological responses to corticosteroids. However, she was diagnosed as peripheral T cell lymphoma, not otherwise specified (PTCL-NOS) by the pulmonary nodular and the skin biopsy almost 10 years later, and she got complete remission within 1 year after chemotherapy.

Conclusion

We report the first case of CLIPPERS developing PTCL-NOS. This case proposes that when brain biopsy was difficult to achieve, biopsies in extra-cerebral lesions under the assisting examination of positron emission tomography-computed tomography (PET-CT) can be helpful in further identification.
Challenges in choice of the treatment strategy for patients with recurrent pseudomyxoma peritonei
Authors: Abdullaev A. G. , Davydov M. M. , Коzlov N. A. 
Published: April 2019

Pseudomixoma peritonei is a rare type of peritoneal carcinomatosis demonstrating an indolent course and a high rate of recurrence. primary surgical interventions in patients with pseudomixoma peritonei are extensive and traumatic, which worsens the chances for performing re-operation and may increase the rate of postoperative complications. above mentioned circumstances forms a problem in the choice of management for patients with recurrent pseudomyxoma peritonei. in this article we present a clinical case of successful treatment of recurrent disease.Сlinical case. The 62 years female patient in 2006 first noticed pain in the lower abdomen. the examination revealed a tumor near the right appendages. on 28.12.2006 the uterus was extirpated with appendages, appendectomy, resection of the large omentum; 6 courses of chemotherapy (cap) were conducted. in may 2007 and June 2009, repeated cytoreductive operations were performed with subsequent 12 courses of chemotherapy. in 2012 a patient with a relapse of the disease was re-operated at the N.N. Blokhin NmRcof oncology. Re-operation was performed in the volume of removal of bulk of the tumor in the right and left sub-diaphragmatic spaces with resection of both domes of the diaphragm, splenectomy, removal of the remaining part of the large omentum, with subsequent hyperthermic intraperitoneal chemoperfusion with cisplatin. complications were not noted. after 14 months, ctand ultrasound revealed progression of the disease. in 2013 an attempt was made to re-surgical intervention. during re-operation in the abdominal cavity a massive adhesive process was found. given the palliative nature of the intervention and the high risk of progression, the volume of surgery is limited to a biopsy of the tumor mass. later 4 courses of chemotherapy were conducted. during period of follow-up, relapse of tumor was noted with the development of partial small intestinal obstruction, which did not require emergency intervention. at present, 26 months after the combined treatment, the patient’s condition is satisfactory, with no signs of intestinal obstruction.Сonclusion. Performance repeated surgical interventions for pseudomixoma peritonei is a rather difficult task for, due to the fact that with continued growth, it is more difficult to achieve optimal cytoreduction. the basic condition for re-operation should be referred to the initial optimal level of cytoreduction and a long-term disease-free period.
Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics
Authors: Dmitrieva N. V. , Eidelshtein M. V. , Aginova V. V. , Perukhova I. N. , Grigorievskaya Z. V. , Bagirova N. S. , Tereshchenko I. V. , Kulaga E. V. , Klyuchnikova I. A. , Sokolova E. N. , Shek E. A. , Skleenova E. Yu. 
Published: April 2019

The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the period 2014–2016. the level of resistance to piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin in dynamics was determined. carbapenem-resistant (car-R) strains were examined for the presence of enzymes.Results. Between 2014 and 2016, the number of strains resistant to piperacillin/tazobactam was 20.1–12.9 %, to ceftazidime – 33.0–32.9 %, to cefepime – 25.6–32.9 %, ciprofloxacin – 36.8–43.8 %, amikacin – 23.8–24.9 %. No statistically significant differences were found (p>0.05). However, an increase in the number of car-R strains from 31.7 to 43.8 % was observed (p<0.05). of 7 strains of P. aeruginosainvestigated for the presence of acquired carbapenemases, the production of metal-beta-lactamase of group Vimwas detected in 2 strains, and class acarbapenemases of the gEs-5 group in one strain.Conclusion. P. aeruginosaresistance to all antibiotic groups did not exceed 50 % and remained almost unchanged for 3 years, with the exception of the increase in car-R strains. three out of 7 (42.9 %) carbapenem-resistant strains were genetically stable.
Assessment of the receptor status in primary breast cancer with synchronous loco regional metastases: prognostic and clinical role?
Authors: Gordeeva O. O. , Zhukova L. G. , Kolyadina I. V. , Ganshina I. P. 
Published: April 2019

Background. Assessment of hormone receptor status plays a crucial role in treatment of patients with breast cancer. currently, clinicians are limited to determining the expression status of estrogen receptor (ER), progesterone receptor (pR) and HER2 only in primary breast cancer tissues, even in the presence of regional metastases.The purpose of the study was to review available data on heterogeneity of ER, pR and HER2/neu expressions in primary breast cancer and regional metastases.Material and methods. We analyzed publications available from pubmed, medline etc. using the keywords «discordance», «breast cancer», «locally advanced», «regional lymph nodes», «ER», «pR», and «HER2».Results. The clinical and prognostic role in assessing the heterogeneity of the receptor status of primary tumors and synchronous regional metastases, as well as the effect of detected discordance on treatment tactics was assessed.Conclusion. Data on the frequency of discordance in hormone receptor status between primary and metastatic breast cancer tumors and its effect on the further prognosis in breast cancer are still contradictory. However, the fact of the presence of such heterogeneity suggests that some patients with affected lymph nodes will have significant benefits from determining the status of steroid hormones and HER2 not only in the primary tumor, but also in the lymph nodes, since it will open up new opportunities for subsequent targeted therapy.
Role of liquid biopsy in the detection and monitoring of cervical cancer
Authors: Kayukova E. V. 
Published: April 2019

Cervical cancer is one of the most common cancers among women of reproductive age. The cytological screening is not always effective and appropriate, therefore the search for new predictive markers of the cervical cancer are of great importance. there are no biomarkers for monitoring patients previously treated for cervical cancer. liquid biopsy is a new option of personalized approach to the detection and monitoring of cervical cancer. it is a set of methods for determining the derivatives of a tumor in biological media, most often in the blood: circulating tumor cells, circulating dNa, RNa, exosomes, etc.The purpose of the studywas to analyze data on the role of liquid biopsy in the diagnosis and monitoring of cervical cancer.Material and methods. We analyzed publications available from pubmed, Elibrary over the past 10 years.Results. Circulating tumor cells, circulating tumor dNa and exosomes are the most studied cancer non-invasive biomarkers. these circulating biomarkers play a key role in the understanding of cervical carcenogenesis, chemo-and radioresistance. currently, liquid biopsy is considered as a promising modern method for the detection and monitoring of cervical cancer. the diagnostic efficiency of this method is good, so it can be used for cervcal cancer screening. However, such statements require further research in this direction. in addition, given the emerging information on the molecular carcinogenesis of cervical cancer, liquid biopsy can also be used as a basis for the development of targeted therapy for locally advanced and generalized cervical cancer.Conclusion. Liquid biopsy is the non-invasive method of cervical cancer monitoring.
Sight, touch, hearing – the current digital options and challenges in access to math content for learners with visual impairments
Authors: Wiazowski Jarosław 
Published: April 2019

Mathematics as a mandatory subject for maturaexams needs to be taken by all high school students, including those with visual impairments. Naczelna Izba Kontroli (or Supreme Audit Office) reported in 2012 that 45% of Polish schools had inadequate learning material for learners with disabilities. It seemed prudent to investigate whether teachers and students have options to choose from. Furthermore the author implies that for any existing digital learning aids to be effective, the best format should be established. Available solutions usually have a combination of input and output methods ranging from visual, auditory to tactile or vibro-tactile systems. The author also discusses advantages and disadvantages of traditional versus digital learning aids and teachers' views of available accessible math instructional solutions.
How do traumatic Shoah-witness testimonies fit into German History Education?
Authors: Morgan Katalin Eszter 
Published: April 2019

This essay traces ways in which traumatic Shoah witness testimonies fit into German history curricula conceptually by highlighting the competencies with which pupils are meant to grasp the topic of National Socialism and the Holocaust. Such curricula are diverse and they keep the learning objectives and teaching methods pertaining to emotions, imagination and ethical dimensions - as relevant to the topic - abstractly vague. This poses certain challenges and opportunities for history teachers and pupils. One such opportunity is the incorporation of virtual video-graphed Shoah witness testimonies that by their nature are emotional as they narrate traumatic memories. The opportunity in such narrations lies in assigning the function of tertiary witnessing to pupils and this process is briefly described. The challenges of using such oral histories can be understood as those that clash with the non-discursively organised knowledge in pursuit of truth (verifiable facts) by means of what is traditionally considered historical evidence.
Zabawa życiem dziecka – aplikacja teorii Froebla do praktyki przedszkolnej XXI wieku
Authors: Bilewicz-Kuźnia Barbara 
Published: April 2019

Artykuł koncentruje się na jednym z trzech filarów koncepcji niemieckiego pedagoga Friedricha Froebla – zabawie – i przedstawia jej znaczenie w świetle jego poglądów oraz kontynuatorów jego myśli we współczesnej pedagogice i metodyce wychowania przedszkolnego. Wiek XXI przyniósł renesans poglądów pedagogicznych Froebla na temat zabawy. Do rzeczywistości przedszkolnej zaimplementowano badania oraz rozwiązania metodyczne pozwalające na nowo uznać, iż zabawa jest życiem dziecka i jednocześnie strategią dydaktyczną.
Argumentação e persuasão na obra de autoajuda Por que os homens se casam com as mulheres poderosas?
Authors: De Figueiredo Allana Mátar , Gomes Tânia Maria De Oliveira 
Published: April 2019

Neste trabalho, pretende-se efetuar uma breve análise argumentativa de alguns trechos da obra de autoajuda feminina Por que os homens se casam com as mulheres poderosas? Um guia para solteiras ou casadas deixarem os homens a seus pés (ARGOV, 2010). Filiando a argumentação a uma problemática retórico-discursiva da influência, conforme algumas propostas de Charaudeau (2008), e utilizando contribuições da Lógica Natural de Grize (2004) e Vignaux (1988, 2004), procuramos identificar as variadas estratégias do projeto argumentativo da autora. Esta, por meio da voz de uma enunciadora, parece ter o intuito de convencer sua destinatária a adotar os comportamentos e falas prescritos na obra, para que, finalmente, a leitora atinja o pretenso sucesso em suas relações afetivas. Dentre as estratégias analisadas, pretende-se mostrar que Argov se serve da construção de imagens estereotipadas e homogeneizadoras da figura feminina, utilizando, para tal, determinadas representações e esquematizações sustentadas em escolhas linguísticas. Tais imagens associam as mulheres à passionalidade extrema, ao descontrole emocional, e se opõem à racionalidade e ao equilíbrio, características atreladas à figura masculina segundo o ponto de vista perceptível na obra, o que acaba por reforçar uma histórica dicotomia emoção versus razão, em detrimento do primeiro componente.
Capas de livros didáticos sob as perspectivas da semiótica social e da abordagem multimodal
Authors: Gualberto Clarice Lage , Pimenta Sônia Maria de Oliveira 
Published: April 2019

Este artigo foi desenvolvido a partir de uma pesquisa de doutorado, cujo objetivo é analisar livros didáticos de lí­ngua portuguesa (LDP), sob perspectiva da Semiótica Social (HODGE; KRESS, 1988; KRESS, 2010) e sob duas abordagens decorrentes desta teoria, sendo elas a multimodalidade e a Gramática do Design Visual (GDV). Na GDV, Kress e van Leeuwen (2006 [1996]) descrevem categorias de análise de imagens, propondo um quadro metodológico sistematizado para o estudo de textos imagéticos. Dessa forma, pretende-se estudar as implicações e possí­veis sentidos produzidos pelas imagens nos LDP. Para compor o presente estudo, são descritas análises das capas de dois LDP destinados í s series finais do ensino fundamental regular. Além disso, na tentativa de abarcar vários modos de representação envolvidos na composição textual, este artigo se ampara também nas categorias de van Leeuwen (2006) para análise da tipografia das capas dos materiais didáticos. O estudo revelou que as capas de cada livro têm propostas bem diferentes e antagônicas. Enquanto um parece ser mais destinado ao governo e passa uma ideia confusa sobre a disciplina de português, o outro sugere uma perspectiva mais inovadora, remetendo à fase de transição em que a maioria dos alunos se encontra. Por fim, este último livro parece associar a disciplina de lí­ngua portuguesa a aspectos positivos, como progressão e desenvolvimento.
Crenças de alunos sobre a leitura de textos multimodais
Authors: Oliveira Marcos Nonato , Lima Eliete Alves de 
Published: April 2019

As crenças e a multimodalidade são temas de pesquisa bastante explorados atualmente no cenário acadêmico. As crenças possibilitam uma melhor compreensão acerca do que pensam alunos e professores dentro do contexto de ensino-aprendizagem. A multimodalidade articula a consciência sobre as várias nuances do texto. Este artigo tem como objetivo discutir as crenças de alunos sobre a leitura crí­tica e sobre a leitura de textos multimodais. Trata-se de um trabalho qualitativo e descritivo. Os sujeitos desta pesquisa foram vinte e quatro alunos do ensino fundamental. Os instrumentos utilizados foram o questionário e a entrevista. A base teórica consta de autores como Kress e van Leeuwen (2001) e Barcelos (2004, 2006). Os resultados apontam para duas perspectivas: uma inicial, em que pudemos observar que os alunos têm acesso a uma variedade grande de textos multimodais, o que é muito produtivo para a formação leitora destes; e outra que revela crenças sobre a leitura crí­tica e a multimodalidade. As crenças dos alunos em relação í s mudanças ocorridas nas suas formas de realizar as leituras é um fato comprovado através dos relatos e dos momentos de interação marcados pela nossa mediação. Portanto, podemos afirmar que é preciso trabalhar a formação leitora com uma visão mais ampla em relação à variedade textual e aos modos semióticos que compõem os textos.