bluuebunny/crossref_metadata_2025_split huggingface dataset:
SiOx Encapsulated in Graphene Bubble Film: An Ultrastable Li‐Ion Battery Anode
Authors: Xu Quan , Sun Jian‐Kun , Yu Zhi‐Long , Yin Ya‐Xia , Xin Sen , Yu Shu‐Hong , Guo Yu‐Guo 
Published: May 2018

AbstractSiOx is proposed as one of the most promising anodes for Li‐ion batteries (LIBs) for its advantageous capacity and stable Li uptake/release electrochemistry, yet its practical application is still a big challenge. Here encapsulation of SiOx nanoparticles into conductive graphene bubble film via a facile and scalable self‐assembly in solution is shown. The SiOx nanoparticles are closely wrapped in multilayered graphene to reconstruct a flake‐graphite‐like macrostructure, which promises uniform and agglomeration‐free distribution of SiOx in the carbon while ensures a high mechanical strength and a high tap density of the composite. The composites present unprecedented cycling stability and excellent rate capabilities upon Li storage, rendering an opportunity for its anode use in the next‐generation high‐energy LIBs.
A Novel Sensing Chip for Probing Chlorine Permeation into Simulated Produce Cracks
Authors: Guan Yongguang , Luo Yaguang , Teng Zi , Zhou Bin , Mei Lei , Bauchan Gary R. , Wang Qin 
Published: May 2018

AbstractPathogen inactivation efficacy is substantially lower on cracks/crevices than on smooth produce surfaces. In this study, an interlocking design of three‐dimensionally printed chip coated with zein‐N,N‐diethyl‐p‐phenylenediamine (DPD) film is developed to study chlorine permeation in simulated cracks. The primary interaction of zein and DPD in film is hydrogen bonding evidenced by the blue shift of the amide II band of zein. The chlorine‐sensing chip exhibits a dose‐dependent magenta color change upon immersion in chlorine solutions. Lab‐scale experiment is performed on chips with full‐depth cracks. At crack widths of 0.2, 0.5, and 1.0 mm, respectively. The static chlorine permeation distances are 11.6, 15.3, and 20.0 mm, when the cracks are perpendicular to the liquid level, compared to 0, 3.3, and 4.3 mm when the cracks are parallel to the liquid level. Complete permeation was detected after dynamic washing for 30 s at chlorine solution Re numbers of 12.5 and 125. In a pilot‐industrial scale washer, chlorine‐permeated distance of 20 mm is detected for full‐depth chlorine‐sensing chips, and 0, 9.4, and 20 mm for half‐depth chips at width of 0.2, 0.5, and 1.0 mm, respectively. Results demonstrated that gravity and boundary pressure facilitates chlorine permeation. This work provides a potential platform for studying the accessibility of sanitizers in narrow gaps under lab‐/industry‐relevant conditions.
Organic Single‐Crystalline Donor–Acceptor Heterojunctions with Ambipolar Band‐Like Charge Transport for Photovoltaics
Authors: Zhao Xiaoming , Liu Tianjun , Zhang Yuteng , Wang Shirong , Li Xianggao , Xiao Yin , Hou Xueyan , Liu Zilu , Shi Wenda , Dennis T. John S. 
Published: May 2018

AbstractSolution‐processed organic single‐crystalline donor–acceptor heterojunctions (SCHJs) composed of N,N,N′,N′‐tetraphenylbenzidine (TPB) and phenyl‐C61‐butyric acid methyl ester ([60]PCBM) are successfully obtained, and fundamental studies on its charge transport properties are demonstrated, revealing the advantages of applying SCHJs in photovoltaic devices. The SCHJs exhibit a balanced high‐mobility ambipolar charge transport with both hole and electron mobility being more than one‐order magnitude higher than its thin‐film heterojunction (TFHJ) counterparts. The difference between single‐crystalline and TFHJs in charge transport mechanisms was revealed, and it is shown that SCHJs present a more favorable band‐like charge transport properties at room temperature. Organic photovoltaics fabricated on SCHJs present much higher current density and a 32‐times higher power conversion efficiencies than TFHJ devices. The present work, which outlines comprehensive advantages of SCHJs in charge transport properties, should accelerate the application of organic single crystals for high‐performance photovoltaics.
Strong Nonlinear Optical Response in the Visible Spectral Range with Epsilon‐Near‐Zero Organic Thin Films
Authors: Lee Yeon Ui , Garoni Eleonora , Kita Hanayo , Kamada Kenji , Woo Byung Hoon , Jun Young Chul , Chae Sang Min , Kim Hyo Jung , Lee Kwang Jin , Yoon Seokhyun , Choi Eunyoung , Mathevet Fabrice , Ozerov Igor , Ribierre Jean Charles , Wu Jeong Weon , D'Aléo Anthony 
Published: May 2018

AbstractEnhanced Kerr nonlinearities are observed in metamaterials such as conducting oxides and doped inorganic semiconductor thin films showing epsilon‐near‐zero (ENZ) response in the infrared region. However, to achieve ENZ in the visible, artificial metamaterials with more complex nanostructures have to be specifically designed. Here, using sodium [5,6‐dichloro‐2‐[[5,6‐dichloro‐1‐ethyl‐3‐(4‐sulphobutyl)‐benzimidazol‐2‐ylidene]‐propenyl]‐1‐ethyl‐3‐(4‐sulphobutyl)‐benzimidazolium hydroxide] and [2,4‐bis[8‐hydroxy‐1,1,7,7‐tetramethyljulolidin‐9‐yl]squaraine] organic thin films, ENZ responses between 450 and 620 nm are demonstrated. Both nonlinear refractive index and nonlinear absorption coefficient are enhanced by more than two orders of magnitude in the ENZ spectral region. These optical effects in the visible spectral range come from the strongly dispersive permittivity of molecular aggregates resulting from the coupling of excitonic transition dipoles. These findings open the path toward a next generation of high‐performance solution‐processable organic nonlinear optical materials with ENZ properties that can be tuned by molecular engineering.
Copper‐Catalyzed Radical Sulfonylation of N‐Propargylindoles with Concomitant 1,2‐Aryl Migration
Authors: Zhu Xin‐Yu , Han Ya‐Ping , Li Ming , Li Xue‐Song , Liang Yong‐Min 
Published: May 2018

AbstractA novel copper‐catalyzed cascade radical sulfonylation of N‐propargyl‐substituted indoles with concomitant 1,2‐aryl migration was described. The protocol, which has good functional‐group tolerance, provides practical, versatile and atom‐economical method of accessing a new class of fascinating 2‐sulfonated pyrrolo[1,2‐α]indole derivatives in moderate to good yields through the formation of the new C−S, C−C and C=O bonds in a one‐step.magnified image
Measuring digit lengths with 3D digital stereophotogrammetry: A comparison across methods
Authors: Gremba Allison , Weinberg Seth M. 
Published: May 2018

AbstractObjectivesWe compared digital 3D stereophotogrammetry to more traditional measurement methods (direct anthropometry and 2D scanning) to capture digit lengths and ratios.MethodsThe length of the second and fourth digits was measured by each method and the second‐to‐fourth ratio was calculated. For each digit measurement, intraobserver agreement was calculated for each of the three collection methods. Further, measurements from the three methods were compared directly to one another. Agreement statistics included the intraclass correlation coefficient (ICC) and technical error of measurement (TEM).ResultsIntraobserver agreement statistics for the digit length measurements were high for all three methods; ICC values exceeded 0.97 and TEM values were below 1 mm. For digit ratio, intraobserver agreement was also acceptable for all methods, with direct anthropometry exhibiting lower agreement (ICC = 0.87) compared to indirect methods. For the comparison across methods, the overall agreement was high for digit length measurements (ICC values ranging from 0.93 to 0.98; TEM values below 2 mm). For digit ratios, high agreement was observed between the two indirect methods (ICC = 0.93), whereas indirect methods showed lower agreement when compared to direct anthropometry (ICC < 0.75).ConclusionsDigit measurements and derived ratios from 3D stereophotogrammetry showed high intraobserver agreement (similar to more traditional methods) suggesting that landmarks could be placed reliably on 3D hand surface images. While digit length measurements were found to be comparable across all three methods, ratios derived from direct anthropometry tended to be higher than those calculated indirectly from 2D or 3D images.
Mitochondrial lineage A2ah found in a pre‐Hispanic individual from the Andean region
Authors: Russo M. G. , Dejean C. B. , Avena S. A. , Seldes V. , Ramundo P. 
Published: May 2018

AbstractObjectivesThe aim of this study was to contribute to the knowledge of pre‐Hispanic Andean mitochondrial diversity by analyzing an individual from the archaeological site Pukara de La Cueva (North‐western Argentina). The date of the discovery context (540 ± 60 BP) corresponds to the Regional Developments II period.MethodsTwo separate DNA extractions were performed from dentin powder of one tooth. HVR I was amplified by PCR from each extract in three overlapping fragments and the haplotype was determined by consensus among all obtained sequences. The procedures were carried out under strict protocols developed for working with ancient DNA.ResultsThe individual belonged to the A2ah lineage due to the presence of the 16097C and 16098G transitions, which constitute its distinctive motif. This lineage is very rare in Native American populations and was described in four individuals from current groups inhabiting the Bolivian Llanos, two from South‐eastern Brazil, and one from the Gran Chaco region. In addition, two other mutations (16260T and 16286T) were shared with one of the individuals from the Bolivian Llanos region.ConclusionsConsidering that the origin of this lineage was postulated for the South American lowlands, the present pre‐Hispanic discovery in the Andean area could be taken as a new evidence of gene flow between these regions. Also, it allows the questioning of the geographical origin of this mitochondrial lineage.
Dose‐response relationships between internally‐deposited uranium and select health outcomes in gaseous diffusion plant workers, 1948‐2011
Authors: Yiin James H. , Anderson Jeri L. , Bertke Stephen J. , Tollerud David J. 
Published: May 2018

ObjectiveTo examine dose‐response relationships between internal uranium exposures and select outcomes among a cohort of uranium enrichment workers.MethodsCox regression was conducted to examine associations between selected health outcomes and cumulative internal uranium with consideration for external ionizing radiation, work‐related medical X‐rays and contaminant radionuclides technetium (99Tc) and plutonium (239Pu) as potential confounders.ResultsElevated and monotonically increasing mortality risks were observed for kidney cancer, chronic renal diseases, and multiple myeloma, and the association with internal uranium absorbed organ dose was statistically significant for multiple myeloma. Adjustment for potential confounders had minimal impact on the risk estimates.ConclusionKidney cancer, chronic renal disease, and multiple myeloma mortality risks were elevated with increasing internal uranium absorbed organ dose. The findings add to evidence of an association between internal exposure to uranium and cancer. Future investigation includes a study of cancer incidence in this cohort.
Palladium‐Titanium Relay Catalysis Enables Switch from Alkoxide‐π‐Allyl to Dienolate Reactivity for Spiro‐Heterocycle Synthesis
Authors: Yang Li‐Cheng , Tan Zher Yin , Rong Zi‐Qiang , Liu Ruoyang , Wang Ya‐Nong , Zhao Yu 
Published: May 2018

AbstractReported herein is the divergent syntheses of [5,5] and [6,5] spiro‐heterocycles under Lewis‐acid‐assisted palladium catalysis. In particular, an unprecedented switch from alkoxide‐π‐allyl to dienolate reactivity was achieved by the use of palladium‐titanium relay catalysis, and represents umpolung reactivity of vinylethylene carbonates. This method uses a simple procedure and commercially available catalysts, and delivers both classes of spiro‐heterocycles, bearing three contiguous stereocenters, in high yield and uniformly excellent diastereoselectivity.
Rapid Electrochemical Assessment of Tumor Suppressor Gene Methylations in Raw Human Serum and Tumor Cells and Tissues Using Immunomagnetic Beads and Selective DNA Hybridization
Authors: Povedano Eloy , Valverde Alejandro , Montiel Víctor Ruiz‐Valdepeñas , Pedrero María , Yáñez‐Sedeño Paloma , Barderas Rodrigo , San Segundo‐Acosta Pablo , Peláez‐García Alberto , Mendiola Marta , Hardisson David , Campuzano Susana , Pingarrón José M. 
Published: May 2018

AbstractWe report a rapid and sensitive electrochemical strategy for the detection of gene‐specific 5‐methylcytosine DNA methylation. Magnetic beads (MBs) modified with an antibody for 5‐methylcytosines (5‐mC) are used for the capture of any 5‐mC methylated single‐stranded (ss)DNA sequence. A flanking region next to the 5‐mCs of the captured methylated ssDNA is recognized by hybridization with a synthetic biotinylated DNA sequence. Amperometric transduction at disposable screen‐printed carbon electrodes (SPCEs) is employed. The developed biosensor has a dynamic range from 3.9 to 500 pm and a limit of detection of 1.2 pm for the methylated synthetic sequence of the tumor suppressor gene O‐6‐methylguanine‐DNA methyltransferase (MGMT) promoter region. The method is applied in the 45‐min analysis of specific methylation in the MGMT promoter region directly in raw spiked human serum samples and in genomic DNA extracted from U‐87 glioblastoma cells and paraffin‐embedded brain tumor tissues without any amplification and pretreatment step.
Carotenoids extracts as natural colorants in poly(lactic acid) films
Authors: Stoll Liana , Rech Rosane , Flôres Simone Hickmann , Nachtigall Sonia Marli Bohrz , de Oliveira Rios Alessandro 
Published: May 2018

ABSTRACTThe use of vivid packaging colors is a strategy to attract consumers' attention and interest. In this context, the awareness of harmful effects caused by the use of synthetic colorants has led to an increasing interest in naturally derived alternatives. The use of carotenoids as colorants for polymeric materials represents an environmentally friendly way of obtaining colored packaging. The incorporation of carotenoids extracts rich in bixin, lycopene, and β‐carotene into poly(lactic acid) films was evaluated, where the presence of carotenoids (100 μg/g) reduced oxygen permeability and presented a lubricant effect, increasing films elasticity up to 50%. No effect on films crystallinity was observed. Carotenoids reduced films transparency and bixin was the most stable carotenoid at dark and light conditions. The color stability of films, evaluated through kinetic parameters of color degradation, presented Chroma half‐life times (40 °C/light) of 111, 51, and 5 days for bixin, lycopene, and β‐carotene, respectively. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46585.
Novel, rosin‐based, hydrophobically modified cationic polyacrylamide for kaolin suspension flocculation
Authors: Zhang Haibo , Jiang Jianxin , Shang Shibin , Song Zhanqian , Song Jie 
Published: May 2018

ABSTRACTA novel, hydrophobically modified cationic polyacrylamide (HMPAM) was synthesized via the copolymerization of acrylamide, diallyl dimethyl ammonium chloride (DMDAAC), and diallylmethyl dehydroabietic acid propyl ester ammonium bromide. Optimum conditions for preparing HMPAM were such that the amount of initiator was 0.075 wt % of the total monomer mass, the monomer concentration was 20 wt %, and the amount of DMDAAC was 18 mol % of the total monomer molar mass. HMPAM was characterized with an UV–visible spectrometer, 1H‐NMR, Ubbelohde viscometer, rotational viscometer, and rotational rheometer. HMPAM solutions exhibited strong hydrophobic associations, and the critical association concentration of the HMPAM aqueous solution was about 0.7 wt %; the HMPAM solutions also showed salt thickening and shear resistance. The surface morphologies of the freeze‐dried HMPAM samples (1 wt %) were also observed via scanning electron microscopy. Compared with unmodified cationic polyacrylamide, Synthesis of HMPAM‐0.5 exhibited a stronger flocculation capacity, and the optimal transmittance of the supernatants was above 95%. HMPAM‐0.5 showed significant flocculation performances for 3–4 and 3–5 wt % kaolin suspensions at 40 and 50 mg/L, respectively. Moreover, the flocculation performance was enhanced with the addition of NaCl and CaCl2. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46637.
Colyers Island: Polynesia's southernmost adze manufacturing complex
Authors: JENNINGS CHRISTOPHER , WEISLER MARSHALL , WALTER RICHARD 
Published: May 2018

ABSTRACTBluff Harbour, in southern New Zealand (Murihiku), is the southernmost location of Polynesian adze production. Here, an industry developed during the colonisation phase based on the exploitation of numerous sources of argillite – a fine‐grained, homogeneous rock with conchoidal fracture properties. Argillite from the Bluff and Riverton sources was a major attractor during the earliest period of human occupation and Bluff argillite adzes were distributed widely throughout the lower South Island. The most extensive sources of Bluff argillite are on Colyers Island, where there is evidence of quarrying and preform production along much of the coast. The sites on Colyers Island were surveyed as the first part of an archaeological investigation of quarrying and adze production in Bluff Harbour. The quarried boulders, outcrops and artefact distributions at these sites indicated that the raw material was exploited by highly organised and skilled craft specialists. The initial stages of adze manufacture were undertaken at the quarry, and then preforms were taken to multipurpose camp sites around the harbour for finishing. Adze blanks on Colyers Island were made from large flakes, tabular blocks and cobbles, using imported hammer stones. This paper documents the significance of Colyers Island as an important adze production complex in New Zealand.
An Economic Evaluation of Stopping Versus Continuing Tumor Necrosis Factor Inhibitor Treatment in Rheumatoid Arthritis Patients With Disease Remission or Low Disease Activity
Authors: Tran‐Duy An , Ghiti Moghadam Marjan , Oude Voshaar Martijn A. H. , Vonkeman Harald E. , Boonen Annelies , Clarke Philip , McColl Geoff , ten Klooster Peter M. , Zijlstra T. R. , Lems Willem F. , Riyazi N. , Griep E. N. , Hazes J. M. W. , Landewé Robert , Bernelot Moens Hein J. , van Riel Piet L. C. M. , van de Laar Mart A. F. J. , Jansen T. L. ,   the Dutch National POET Collaboration
Published: May 2018

ObjectiveTo evaluate, from a societal perspective, the incremental cost‐effectiveness of withdrawing tumor necrosis factor inhibitor (TNFi) treatment compared to continuation of these drugs within a 1‐year, randomized trial among rheumatoid arthritis patients with longstanding, stable disease activity or remission.MethodsData were collected from a pragmatic, open‐label trial. Cost‐utility analysis was performed using the nonparametric bootstrapping method, and a cost‐effectiveness acceptability curve was constructed using the net‐monetary benefit framework, where a willingness‐to‐accept threshold (WTA) was defined as the minimal cost saved that a patient accepted for each quality‐adjusted life year (QALY) lost.ResultsA total of 531 patients were randomized to the stop group and 286 patients to the continuation group. Withdrawal ofTNFi treatment resulted in a >60% reduction of the total drug cost, but led to an increase of ∼30% in other health care expenditures. Compared to continuation, stoppingTNFi resulted in a mean yearly cost saving of €7,133 (95% confidence interval [95%CI] €6,071, €8,234]) and was associated with a mean loss ofQALYs of 0.02 (95%CI0.002, 0.040). Mean saved cost perQALYlost and per extra flare incurred in the stop group compared to the continuation group was €368,269 (95%CI€155,132, €1,675,909) and €17,670 (95%CI€13,650, €22,721), respectively. At aWTAof €98,438 perQALYlost, the probability that stoppingTNFi treatment is cost‐effective was 100%.ConclusionAlthough an officialWTAis not defined, the mean saved cost of €368,269 perQALYlost seems acceptable in The Netherlands, given existing data on willingness to pay.
An HPLC‐UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications
Authors: Mahale Jagdish , Howells Lynne M. , Singh Rajinder , Britton Robert G. , Cai Hong , Brown Karen 
Published: May 2018

AbstractCurcumin, derived from turmeric, has been extensively investigated for its broad spectrum of biological activities. Previously reported HPLC‐UV methods have focussed on analysis of the parent compound. Here, a sensitive HPLC‐UV method was developed and partially validated, then used for the simultaneous determination of curcumin and its glucuronide and sulfate metabolites in plasma and lung tissue from mice. The assay was applied to an in vivo pharmacokinetic study comparing formulated curcumin (Meriva™) with standard curcumin. Plasma levels of glucuronide and sulfate metabolites were 5‐ and 2‐fold higher after Meriva™ administration compared with standard curcumin. In lung tissue, free curcumin was 4‐fold higher following Meriva™ administration vs standard curcumin. This assay represents a rapid, cheap method for simultaneous detection of curcumin and its major metabolites that has applicability in pre‐clinical settings.
Local control and possibility of tailored salvage after hypofractionated stereotactic radiotherapy of the cavity after brain metastases resection
Authors: Bilger Angelika , Bretzinger Eva , Fennell Jamina , Nieder Carsten , Lorenz Hannah , Oehlke Oliver , Grosu Anca‐Ligia , Specht Hanno M. , Combs Stephanie E. 
Published: May 2018

AbstractIn patients undergoing surgical resection of brain metastases, the risk of local recurrence remains high. Adjuvant whole brain radiation therapy (WBRT) can reduce the risk of local relapse but fails to improve overall survival. At two tertiary care centers in Germany, a retrospective study was performed to evaluate the role of hypofractionated stereotactic radiotherapy (HFSRT) in patients with brain metastases after surgical resection. In particular, need for salvage treatment, for example, WBRT, surgery, or stereotactic radiosurgery (SRS), was evaluated. Both intracranial local (LF) and locoregional (LRF) failures were analyzed. A total of 181 patients were treated with HFSRT of the surgical cavity. In addition to the assessment of local control and distant intracranial control, we analyzed treatment modalities for tumor recurrence including surgical strategies and reirradiation. Imaging follow‐up for the evaluation of LF and LRF was available in 159 of 181 (88%) patients. A total of 100 of 159 (63%) patients showed intracranial progression after HFSRT. A total of 81 of 100 (81%) patients received salvage therapy. Fourteen of 81 patients underwent repeat surgery, and 78 of 81 patients received radiotherapy as a salvage treatment (53% WBRT). Patients with single or few metastases distant from the initial site or with WBRT in the past were retreated by HFSRT (14%) or SRS, 33%. Some patients developed up to four metachronous recurrences, which could be salvaged successfully. Eight (4%) patients experienced radionecrosis. No other severe side effects (CTCAE≥3) were observed. Postoperative HFSRT to the resection cavity resulted in a crude rate for local control of 80.5%. Salvage therapy for intracranial progression was commonly needed, typically at distant sites. Salvage therapy was performed with WBRT, SRS, and surgery or repeated HFSRT of the resection cavity depending on the tumor spread and underlying histology. Prospective studies are warranted to clarify whether or not the sequence of these therapies is important in terms of quality of life, risk of radiation necrosis, and likelihood of neurological cause of death.