bluuebunny/crossref_metadata_2025_split huggingface dataset:
Irracionalizando la razón patriarcal
Authors: Serret Bravo Estela Andrea 
Published: February 2025

Este artículo analiza las preocupaciones conceptuales de Celia Amorós en su libro Hacia una crítica de la razón patriarcal a partir de un hilo conductor: la equivalencia simbólica entre los pares hombre-cultura y mujer-naturaleza, presente en toda ideología patriarcal, tal como constata el análisis estructuralista de Lévi-Strauss, se manifiesta acríticamente tanto en autores clave del canon filosófico occidental como en la narrativa de los llamados feminismos de la diferencia. La autora desmenuza los múltiples encadenamientos semánticos de esa equivalencia simbólica y muestra tanto la incongruencia que su reproducción conceptual entraña, como las graves implicaciones políticas que un feminismo de la igualdad permite evidenciar y combatir.
Palabras clave: crítica feminista; hombre-cultura::mujer-naturaleza; antropología estructural; filosofía patriarcal; feminismo de la diferencia
Immunogenicity of experimental DNA vaccines encoding hemagglutinin and hemagglutinin stalk of influenza A (H5N8) virus
Authors: Litvinova V. R. , Rudometova N. B. , Kisakova L. A. , Kisakov D. N. , Yakovlev V. A. , Tigeeva E. V. , Borgoyakova M. B. , Ivanova K. I. , Marchenko V. Yu. , Ilyicheva T. N. , Karpenko L. I. , Rudometov A. P. , Ilyichev A. A. 
Published: February 2025

Avian influenza A virus subtype H5 is widespread in the bird population, and there is a risk of its transmission to humans, therefore, it is necessary to develop an effective vaccine to prevent virus spread. The aim of the work was to develop prototypes of DNA vaccines encoding modified variants of the hemagglutinin trimer of highly pathogenic avian influenza A virus (H5N8) and its fragment (stem) and to study their immunogenic properties. Material and methods. DNA constructs were designed, produced and purified, their expression was analyzed in eukaryotic cells using reverse transcription PCR and Western blot analysis. Laboratory animals (Syrian hamsters) were immunized with experimental DNA vaccines using the jet injection method, the antibody titer in their sera was determined using ELISA. The sera were also tested in the virus neutralization reaction in MDCK cell culture. Results and discussion. Expression of target genes in experimental DNA vaccines was confirmed at the transcription and translation levels. Immunogenicity analysis showed that immunization of Syrian hamsters with pVAX-H5 and pVAX-H5 delT4 constructs encoding hemagglutinin ectodomain variants with and without the fibritin trimerizing domain of bacteriophage T4 using jet injection resulted in the formation of specific antibodies (average titer 1:3×104 and 1:5×103, respectively) with virus-neutralizing activity (average 50 % neutralizing titer 1:40). At the same time, specific antibodies were not detected in the group of animals immunized with the DNA vaccine encoding the hemagglutinin stalk. Conclusions. In the course of the work, DNA vaccines encoding variants of the hemagglutinin trimer of the influenza virus subtype A (H5N8) and its fragment (stem) were designed and obtained. A comparison of the immunogenicity of experimental DNA vaccines was conducted and the most promising variant of the design – pVAX-H5, encoding a modified trimer of the hemagglutinin of the influenza virus with a trimerizing domain of the fibritin of the bacteriophage T4 – was established.
Awareness of doctors as a component of medical determinant of public health (on the example of determining the level of knowledge of pediatricians about early diagnosis and treatment of Duchenne muscular dystrophy)
Authors: Sakbaeva G. E. , Russkikh S. V. , Vasilyeva T. P. , Gremyakova T. A. , Stepanov A. A. , Tarasenko E. A. 
Published: February 2025

Duchenne muscular dystrophy is a rare progressive neuromuscular disease that is diagnosed in early childhood and leads to a significant reduction in life expectancy. Based on clinical guidelines, the authors of this article developed a questionnaire for pediatricians to determine the knowledge of primary care physicians about early diagnosis and treatment of patients with this rare genetic disease. Material and methods. Using the method of quantitative sociological survey, we determined the awareness of pediatricians about a rare genetic disease. The basis for the quantitative analysis was data from an online survey with 609 respondents who were pediatricians. Results and its discussion. Less than half of the respondents (48 %) showed a high level of knowledge, were ready to diagnose the disease correctly, to carry out dispensary monitoring of patients. Every third respondent has knowledge that is insufficient to diagnose and manage patients with Duchenne muscular dystrophy. Also, during the survey, the authors of the article found out the opinion of pediatricians about the sufficiency and/or insufficiency of their knowledge in the management of patients, as well as their preferences in channels for obtaining new information about this disease. Conclusions. Pediatricians play a major role in the early diagnosis of Duchenne muscular dystrophy. In this regard, the training of pediatricians in accordance with the new clinical guidelines should be included in the training and improvement of doctors’ knowledge. Addressing this issue could lead to significant clinical and economic benefits.
Quality Management Practices and Performance: The Perspective of Public Healthcare Institutions in Kenya
Authors: Jumapili Dorcas Nyangulika , Muathe Stephen Makau A. 
Published: February 2025

The global economy's transformations have prompted public healthcare institutions in Kenya to adopt strategies to expand their markets, improve customer satisfaction, and enhance operational efficiency globally. The county government of Tharaka Nithi and the Kenyan national government have implemented initiatives to enhance public healthcare facilities, but their performance remains below the required standards. According to The World Health Organization reports Kenya's public healthcare institutions provided 75% unsatisfactory services to customers, while their services remained at 6.6% from 2017 to 2020. Therefore, the current study investigates the effect of quality management practices on the performance of public healthcare institutions in Tharaka Nithi County, Kenya. Specifically, the study examined the effect of customer focus and continuous improvement on the performance of public healthcare institutions in Tharaka Nithi County, Kenya. The study used Scorecard, Six Sigma theories as well as the upper echelon theory. The study embraced descriptive research design. The target population was eight hundred and eighty-three employees of public healthcare institutions in Tharaka Nithi County, Kenya. Stratified random sampling techniques were used as a sampling technique to select 275 respondents that were determined scientifically through a formula. Primary data was collected using a structured self-administered questionnaire. A pilot test of twenty-eight respondents was conducted. The study instrument's reliability and validity were evaluated using Cronbach's alpha coefficient, with a threshold of 0.7 or higher. The collected data was analyzed using descriptive and inferential statistics, which were presented in the form of tables, charts, and graphs. The findings were that strengthening customer focus (p<0.05), continuous improvement (p<0.05) and top management commitment (p<0.05) can contribute towards a significant improvement in the performance of public healthcare institutions in Tharaka Nithi County, Kenya. The study concluded that total quality management practices are significant enablers of the organizational performance of an institution. The study recommended that employees working with public healthcare institutions in Tharaka Nithi County should be motivated to address customer inquiries promptly to improve the level of efficiency and effectiveness. The operational managers and all other heads of the functional areas in the public healthcare institutions in Tharaka Nithi County design their processes effectively for effective decision-making. Employees should be encouraged to use errors reported as the basis for further improvement in processes.
Examining the Risk of Delirium Among Residents with Diabetes in Long-Term Care Homes Across Ontario
Authors: Heale Roberta , Gorham Robyn , Rietze Lori , Hill Laura 
Published: February 2025

Aim: To examine risk factors for delirium in residents with diabetes in Ontario’s LTC homes. Scope: Residents in long-term care (LTC) are vulnerable to negative outcomes related to diabetes, including delirium. Understanding factors related to the risk of delirium for residents with diabetes provides the foundation for the mitigation of delirium in this population. Methods: A population-based retrospective analysis of the RAI-MDS dataset (2019–2020) was conducted. Findings: Diabetes was associated with a statistically significant increased risk of delirium (Odds Ratio: 1.073, CI 1.038–1.109), compounded by polypharmacy. Conclusions: Comprehensive delirium mitigation strategies are needed for this vulnerable population. Strategies to mitigate delirium in this population should be implemented.
Pengembangan Media Smart Monsuba Pada Pembelajaran IPAS untuk Meningkatkan Hasil Belajar Siswa Kelas V SDN Kranding
Authors: Muhaimin Rian Ahmad , Putra Galih Mahardika Christian 
Published: February 2025

Penelitian ini bertujuan untuk mengembangkan serta menguji desain media pembelajaran Smart Monsuba untuk meningkatkan hasil belajar siswa kelas V di SDN Kranding Kabupaten Pekalongan pada mapel pelajaran Ilmu Pengetahuan Alam serta Sosial (IPAS). Penelitian ini menggunakan pengembangan Borg And gall. Populasi penelitian berjumlah total 30 orang, dengan masing-masing untuk skala kecil serta skala besar yakni 6 serta 24 subjek siswa.. Penelitian diawali dengan melakukan observasi mengenai penggunaan media pembelajaran, kemudian dilanjutkan dengan pengumpulan data secara tes (Pretest serta Posttest) serta non tes sepeti angket, wawancara, serta dokumentasi. Validasi ahli materi mendapat nilai 90%, sedangkan ahli media 94,73%. Hasil penelitian menggunakan media pembelajaran Smart Monsuba menunjukkan terjadinya peningkatan hasil belajar dibuktikan melalui skor rata-rata dari 54 menjadi 79 untuk skala kecil, serta rata-rata 50 ke 81 untuk skala besar. Pada hasil nilai uji N-Gain sebesar 0, 552 pada skala kecil serta 0,625 pada skala besar. Hal tersebut menunjukkan peningkatan belajar yang cukup tinggi. Simpulan penelitian menunjukkan keefiktifan media Smart monsuba dalam peroses pembelajaran, serta menunjukkan Media Smart monsuba sebagai media yang menarik minat siswa serta , mudah digunakan serta mampu meningkatkan hasil belajar siswa.
Co-inoculation of a pectinolytic <i>Aureobasidium pullulans</i> strain and <i>Saccharomyces cerevisiae</i> for low-temperature red fermentation: A strategy to enhance the colour and sensory properties of Malbec wines
Authors: Merín María , Martín María , Carrión Raúl , Morata Vilma 
Published: February 2025

Low-temperature fermentation is employed to improve aroma production and retention in red wines but at the expense of polyphenol and pigment extraction. In this study, the strategy of co-inoculating the pectinolytic strain Aureobasidium pullulans GM-R-22 with a commercial Saccharomyces cerevisiae for the low-temperature fermentation (LTF, 17.5 °C) of Malbec red grapes was evaluated at pilot scale, and compared with a traditional fermentation (TF, 25 °C), to compensate for the lower extraction of colour and polyphenols at low maceration temperature. The effects of this strategy on the chromatic, phenolic, technological, antioxidant and sensory properties of Malbec wines were assessed during fermentation and up to 12 months of bottle storage. A. pullulans (Ap) grew and remained viable during 4 days of LTF, without affecting the fermentation and growth kinetics of S. cerevisiae (Sc), and significantly higher levels of pectinase activity (about 4.5-fold) were detected in LTF (Ap + Sc) compared to LTF (Sc) and TF (Sc) vinifications. At the end of the fermentation, LTF (Ap + Sc) wine showed higher colour intensity (CI), total anthocyanins (TA), total polyphenolic index (TPI) and a* with a lower L*, b* and filtration time (25 %) than LTF (Sc) wine. After 12 months of bottle storage, CI, TPI, TA and monomeric, copigmented and polymeric anthocyanins were significantly higher in LTF (Ap + Sc) than in LTF (Sc) and statistically equal to TF (Sc), although the CIELAB parameters and the antioxidant activity showed no statistical differences compared to control wines. Sensory analysis showed that the LTF (Ap + Sc) wine had greater colour intensity and violet hue than the LTF (Sc) wine, reaching the colour attribute scores of the TF (Sc) wine, and was particularly characterised by a spicy aroma, unlike the wines fermented in the absence of A. pullulans. This is the first study to demonstrate the performance of A. pullulans in pilot-scale fermentation and the efficiency of its pectinases in improving the extraction and stability of red wine colour fermented at low temperatures, approaching or achieving the levels of chromatic and phenolic parameters of the traditionally fermented Malbec wine.
Rate of Osteonecrosis After Femoral Lengthening with Intramedullary Lengthening Nails
Authors: Dubin Jeremy A. , Swartz Gabrielle N. , Bains Sandeep S. , Gottlich Caleb , Herzenberg John E. , McClure Philip K. 
Published: February 2025

Background:
There has been historical concern that the use of intramedullary nails could present undue risk of osteonecrosis of the femoral head due to compromise of the femoral blood supply. Intramedullary lengthening nails are rapidly becoming commonplace in lengthening procedures. As such, the primary objective of this study was to analyze the rates of osteonecrosis following femoral lengthening. The secondary objective was to characterize general trends in femoral lengthening.

Methods:
This retrospective cohort study evaluated patients who had undergone femoral lengthening at a single institution from 2012 to 2021. Retrospective chart review and radiographic evaluation of osteonecrosis were conducted. The primary end point was radiographic evidence of osteonecrosis. The secondary variables were the starting point of the femoral nail, the total amount of lengthening, and the time to consolidation.

Results:
Two hundred and forty-seven patients were included in the analysis, including 111 males and 136 females, with a mean age of 17 years. No patient had radiographic evidence of osteonecrosis (0%) or coxa valga (0%). The average amount of lengthening was 4.88 cm (range, 1.5 to 8.5 cm). No patient had any extensive complications, such as alterations in the proximal femoral anatomy.

Conclusions:
This largest study to date investigating complications following femoral lengthening using intramedullary lengthening nails revealed that femoral lengthening is a well-tolerated procedure, and osteonecrosis is an infrequent complication.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
AI-SSIM: Human-Centric Image Assessment through Pseudo-Reference Generation and Logical Consistency Analysis in AI-Generated Visuals
Authors: Danish Muhammad Umair , Aziz Memoona , Grolinger Katarina , Rehman Umair 
Published: February 2025

Abstract

We present AI-SSIM, a computational image metric for assessing the quality and logical consistency of AI-generated and real-world images. Traditional metrics like structural similarity index measure (SSIM) and multi-scale structural similarity index measure (MS-SSIM) require a ground-truth image, which is often unavailable in AI-generated imagery, and overlook key factors such as logical coherence and content usability. AI-SSIM addresses these gaps by employing advanced pre-trained models to generate a pseudo-reference image, convolution and attention layers to evaluate image quality, and adaptive pooling to minimize distortion during resizing pseudo-reference images. We also designed and statistically validated a multi-item questionnaire for assessing image quality. AI-SSIM was benchmarked against human scales and compared to both full-reference and no-reference metrics, where it demonstrated superior accuracy. The proposed metric has broad applicability, as it can compute scores in both scenarios where ground-truth images are either available or absent.
Mass-spectrometry-based proteomics enables rapid and accurate diagnosis of Lyme neuroborreliosis in adults
Authors: Albrechtsen Nicolai Wewer , Nielsen Annelaura , Fjordside Lasse , Drici Lylia , Ottenheijm Maud , Rasmussen Christine , Henningsson Anna , Harritshøj Lene H. , Mann Matthias , Lebech Anne-Mette 
Published: February 2025

Abstract

Lyme neuroborreliosis (LNB), a severe nervous system infection caused by tick-borne spirochetes of the Borrelia burgdorferi sensu lato complex, represents one of the most frequent bacterial infections of the nervous system in Europe. Early diagnosis remains challenging due to limited sensitivity of current methods and requires invasive lumbar punctures, underscoring the need for improved, less invasive diagnostic tools.
Here, we applied mass spectrometry-based proteomics to analyse 308 cerebrospinal fluid (CSF) samples and 207 plasma samples from patients with LNB, viral meningitis, controls and other manifestations of Lyme borreliosis. Diagnostic panels of regulated proteins were identified and evaluated through machine learning-assisted proteome analyses.
In CSF, the classifier distinguished LNB from viral meningitis and controls with AUCs of 0.92 and 0.90, respectively. In plasma, LNB was distinguished from controls with an AUC of 0.80.
Our findings highlight the diagnostic potential of machine learning-assisted proteomics for LNB in CSF and plasma.
Effects of genotype × environment interactions on the morphological and genetic aspects of the seed characteristics of faba beans
Authors: Mahmoud Salwa M. , Amro Ahmed , Elfarash Ameer , Börner Andreas , Sallam Ahmed 
Published: February 2025

Abstract

Faba bean (Vicia faba L.) is one of the oldest crops in the world. It is the third most important feed grain legume globally, after wheat and barley (Singh et al. 2013). It is an autogamous plant with 20% to 80% partial outcrossing. The objective of most crop improvement programs in faba beans is to improve yield, but yield is a complex trait that is correlated with many other traits; therefore, in this study, we focused on important traits related to faba bean improvement to increase yield, which is associated with seed characteristics. We used 110 genotypes in this study to investigate SNPs related to seed characteristics. We detected high genetic variation among all the traits. There was a strong positive correlation between the seed characteristics at the two locations. The genotype ×location (G×L) interactions were highly significant. FB-231 and FB-227 performed very well in both countries based on the SI values, whereas FB-193 and FB-185 had the lowest SI values in both countries. All genotypes were genotyped via single primer enrichment technology (SPET). As a result, we identified 33,165 SNP markers. ChrVF1L1 had the highest number of SNP markers. The total number of significant SNPs detected in Germany (162) and Egypt (31) was based on the suggestive p-value. A set of 11 SNPs was associated with more than one seed trait in Germany, whereas only one SNP was associated with two traits in Egypt.
The Impact Of Dual Trigger Stimulation Upon Reproductive Outcomes In Woman Of Advanced Maternal Age – A Large Retrospective Study
Authors: Chatziioannou Stylianos Sergios , Nikolaos Christoforidis , Chatziparasidou Alexia , Papatheodorou Achilleas , Kolias Pavlos , Drakopoulos Panagiotis 
Published: February 2025

Abstract

Background
Poor ovarian response (POR) in women aged 40 and above presents significant challenges in in vitro fertilization (IVF). This study evaluated whether dual trigger strategy, involving a combination of gonadotropin-releasing hormone (GnRH) agonists and human chorionic gonadotropin (hCG), improves IVF outcomes compared to human chorionic gonadotropin (hCG) alone in women of advanced maternal age.
Methods
A retrospective cohort study was conducted, analysing 2,199 IVF cycles from 1,451 women between January 2018 and June 2022. Among these cycles, 327 cycles utilized a dual trigger strategy while 1,124 had an hCG trigger. Key outcomes assessed included the number of metaphase II (MII) oocytes, fertilization rates, fresh embryo transfers on days 5/6, and pregnancy outcomes. Multivariate regression was employed to adjust for variables such as age, BMI, gonadotropin dosage, stimulation duration, and anti-Müllerian hormone levels.
Results
The dual trigger group showed significantly higher rates of embryo transfer on days 5/6 (34.1% vs. 16.5%, p < 0.001). While there were no significant differences in the number of MII oocytes or fertilization rates (p = 0.16), adjusted analysis indicated a modest increase in MII oocytes (RR = 1.1, 95% CI 1.00–1.21). Positive hCG rates were lower in the dual trigger group (18.5% vs. 24.7%, p = 0.007), and cumulative live birth rates were not significantly different (8.9% vs. 13.2%, p = 0.009).
Conclusions
Dual trigger protocols may enhance certain ovarian response parameters but do not significantly improve pregnancy or live birth rates in older women with diminished ovarian reserve. Future studies are necessary to optimize and personalize treatment strategies for this challenging patient population.
Trial Registration:
Approved by the local ethical committee (Approval 17/07/2024).
Understanding Psychological Help-Seeking in Portuguese University Students: Influences of Personality Traits, Gender, Academic and Socioeconomic Factors
Authors: Koppensteiner Laura , Silva Vânia , Ribeiro Eugénia 
Published: February 2025

Abstract

University students are at risk for the development of psychological problems, and their attitudes/intentions toward seeking help have been studied concerning personality traits and socio-demographics. This study utilized a convergent parallel mixed methods design, with 400 Portuguese students participating. Quantitatively, it assessed how personality traits, gender, and socioeconomic status influence attitudes, and it also considered the year of study, the scientific area, and students' intentions. The five personality traits (NEO-FFI) and attitudes (IASMHS) were analyzed. Results indicated that Openness, Conscientiousness, and Agreeableness correlated with more positive attitudes, and students who identify as women tended to have better attitudes than men. Social Science students expressed a greater intention to seek help. Qualitatively, the content analysis results showed that some students more frequently reported reasons, like understanding the need for seeking psychological help and favorable attitudes for seeking help, as facilitators. Regarding barriers, the students diverge into various factors, with intrapersonal dilemmas, stigma, and negative attitudes as the most frequently reported.