bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Standing Highly Conductive Solid Electrolytes Based on Block Copolymers for Rechargeable All‐Solid‐State Lithium‐Metal Batteries
Authors: Aldalur Itziar , Martinez‐Ibañez Maria , Piszcz Michal , Zhang Heng , Armand Michel 
Published: August 2018

AbstractSolid polymer electrolytes (SPEs) have been emerging as attractive candidates for meeting the demand in safe and high energy density batteries, attributed to their low flammability and ease in process. The architectural design of polymer matrices can improve the physicochemical and electrochemical properties of SPEs, thus leading to an enhanced performance of rechargeable all‐solid‐state lithium metal (Li0) batteries (ASSLMBs). However, for the majority of the reported SPEs, high ionic conductivities are achieved at the expense of their mechanical stiffness that is crucial for the processing of ASSLMBs. Herein, we report a new type of self‐standing and highly conductive SPE based on tailor‐made block copolymers, containing highly flexible Jeffamine‐based blocks and mechanically stable polystyrene moieties. The synthesis is facile and “one‐pot”. The electrolytes exhibit good mechanical properties and high ionic conductivities (5.6×10−4 S cm−1 at 70 °C and 7.9×10−5 S cm−1 at 40 °C). The superior compatibility with Li0 electrode allows the electrolyte to be cycled in a Li0||LiFePO4 cell with good coulombic efficiency and low capacity fading. The tailor‐made block copolymers offer a potential entry to safe and high‐performance ASSLMBs.
Determination of trehalose by ion chromatography and its application to a pharmacokinetic study in rats after intramuscular injection
Authors: Chen Hui , Chen Weizhu , Hong Bihong , Zhang Yiping , Hong Zhuan , Yi Ruizao 
Published: August 2018

AbstractAn ion chromatography method was established for detecting trehalose in rat plasma. The samples were analyzed using a CPMA1 column (250 × 4.0 mm, Thermo) with 120 mm NaOH as eluent at a flow rate of 0.7 mL/min. The standard curve was y = 1.4316x − 0.0654 (R = 0.9992), and the linear range was 0.2–10 mg/L. The relative standard deviations of within‐run and between‐run precisions at low, medium and high concentrations were within 0.96–8.33%, and the accuracy was within 80.09–114.99%. The method was verified by rigorous methods, and applied to a pharmacokinetic study in rats after intramuscular injection (20 mg/kg, n = 6). The pharmacokinetic parameters, specifically AUC0–t, AUC0–∞, t1/2, CL and Vd, were 15.542 ± 3.122 mg h/L, 15.599 ± 3.141 mg h/L, 0.73 ± 0.347 h, 1.331 ± 0.293 L/h kg and 1.403 ± 0.735 L/kg, respectively. The developed ion chromatography method met the requirements of biological sample measurement, and will be helpful for future pharmacological studies of trehalose.
Expanding the Applicability of the Metal Labeling of Biomolecules by the RIKEN Click Reaction: A Case Study with Gallium‐68 Positron Emission Tomography
Authors: Nakamoto Yuka , Pradipta Ambara R. , Mukai Hidefumi , Zouda Maki , Watanabe Yasuyoshi , Kurbangalieva Almira , Ahmadi Peni , Manabe Yoshiyuki , Fukase Koichi , Tanaka Katsunori 
Published: August 2018

AbstractRadiolabeled biomolecules with short half‐life times are of increasing importance for positron emission tomography (PET) imaging studies. Herein, we demonstrate an improved and generalized method for synthesizing a [radiometal]‐unsaturated aldehyde as a lysine‐labeling probe that can be easily conjugated into various biomolecules through the RIKEN click reaction. As a case study, 68Ga‐PET imaging of U87MG xenografted mice is demonstrated by using the 68Ga‐DOTA‐RGDyK peptide, which is selective to αVβ3 integrins.
Visualization of descriptive multiblock analysis
Authors: Skotare Tomas , Sjögren Rickard , Surowiec Izabella , Nilsson David , Trygg Johan 
Published: August 2018

AbstractUnderstanding and making the most of complex data collected from multiple sources is a challenging task. Data integration is the procedure of describing the main features in multiple data blocks, and several methods for multiblock analysis have been previously developed, including OnPLS and JIVE. One of the main challenges is how to visualize and interpret the results of multiblock analyses because of the increased model complexity and sheer size of data. In this paper, we present novel visualization tools that simplify interpretation and overview of multiblock analysis. We introduce a correlation matrix plot that provides an overview of the relationships between blocks found by multiblock models. We also present a multiblock scatter plot, a metadata correlation plot, and a variation distribution plot, that simplify the interpretation of multiblock models. We demonstrate our visualizations on an industrial case study in vibration spectroscopy (NIR, UV, and Raman datasets) as well as a multiomics integration study (transcript, metabolite, and protein datasets). We conclude that our visualizations provide useful tools to harness the complexity of multiblock analysis and enable better understanding of the investigated system.
Solvent‐Induced and Temperature‐Promoted Aggregation of Bipyridine Platinum(II) Triangular Metallacycles and Their Near‐Infrared Emissive Behaviors
Authors: Ai Yeye , Ng Maggie , Hong Eugene Yau‐Hin , Chan Alan Kwun‐Wa , Wei Zhang‐Wen , Li Yongguang , Yam Vivian Wing‐Wah 
Published: August 2018

AbstractA series of bipyridine platinum(II) complexes with different sizes of triangular metallacycles and alkyl/oligoether chains has been synthesized and characterized. They are packed in a zig‐zag fashion with the formation of dimeric structures according to their X‐ray crystal structures. Different emission origins are observed due to the different sizes of the triangular ligands. Their morphologies could be tuned by the modification of the molecular structures with different metallacyclic alkynyl ligands and alkyl/oligoether chains and solvents. More interestingly, unusual electronic absorption changes and upfield shifts of the aromatic proton resonances are observed upon increasing the temperature, suggesting further aggregation of the architectures. Near‐infrared (NIR) emission is also realized through the tuning of the π–π stacking, Pt⋅⋅⋅Pt interactions, and the packing of planar metallacycles.
The Important Role of the Nuclearity, Rigidity, and Solubility of Phosphane Ligands in the Biological Activity of Gold(I) Complexes
Authors: Svahn Noora , Moro Artur J. , Roma‐Rodrigues Catarina , Puttreddy Rakesh , Rissanen Kari , Baptista Pedro V. , Fernandes Alexandra R. , Lima João Carlos , Rodríguez Laura 
Published: August 2018

AbstractA series of 4‐ethynylaniline gold(I) complexes containing monophosphane (1,3,5‐triaza‐7‐phosphaadamantane (pta; 2), 3,7‐diacetyl‐1,3,7‐triaza‐5‐phosphabicyclo[3.3.1]nonane (3), and PR3, with R=naphthyl (4), phenyl (5), and ethyl (6)) and diphosphane (bis(diphenylphosphino)acetylene (dppa; 7), trans‐1,2‐bis(diphenylphosphino)ethene (dppet; 8), 1,2‐bis(diphenylphosphino)ethane (dppe; 9), and 1,3‐bis(diphenylphosphino)propane (dppp; 10)) ligands have been synthesized and their efficiency against tumor cells evaluated. The cytotoxicity of complexes 2–10 was evaluated in human colorectal (HCT116) and ovarian (A2780) carcinoma as well as in normal human fibroblasts. All the complexes showed a higher antiproliferative effect in A2780 cells, with the cytotoxicity decreasing in the following order 5>6=9=10>8>2>4>7>3. Complex 4 stands out for its very high selectivity towards ovarian carcinoma cells (IC50=2.3 μm) compared with colorectal carcinoma and normal human fibroblasts (IC50>100 μm), which makes this complex very attractive for ovarian cancer therapy. Its cytotoxicity in these cells correlates with the induction of the apoptotic process and an increase of intracellular reactive oxygen species (ROS). The effects of the nuclearity, rigidity, and solubility of these complexes on their biological activity were also analyzed. X‐ray crystal structure determination allowed the identification of short N−H⋅⋅⋅π contacts as the main driving forces for the three‐dimensional packing in these molecules.
X‐ray Crystal Structures Show DNA Stacking Advantage of Terminal Nitrile Substitution in Ru‐dppz Complexes
Authors: McQuaid Kane , Hall James P. , Brazier John A. , Cardin David J. , Cardin Christine J. 
Published: August 2018

AbstractThe new complexes [Ru(TAP)2(11‐CN‐dppz)]2+, [Ru(TAP)2(11‐Br‐dppz)]2+and [Ru(TAP)2(11,12‐diCN‐dppz)]2+ are reported. The addition of nitrile substituents to the dppz ligand of the DNA photo‐oxidising complex [Ru(TAP)2(dppz)]2+ promote π‐stacking interactions and ordered binding to DNA, as shown by X‐ray crystallography. The structure of Λ‐[Ru(TAP)2(11‐CN‐dppz)]2+ with the DNA duplex d(TCGGCGCCGA)2 shows, for the first time with this class of complex, a closed intercalation cavity with an AT base pair at the terminus. The structure obtained is compared to that formed with the 11‐Br and 11,12‐dinitrile derivatives, highlighting the stabilization of syn guanine by this enantiomer when the terminal base pair is GC. In contrast the AT base pair has the normal Watson–Crick orientation, highlighting the difference in charge distribution between the two purine bases and the complementarity of the dppz–purine interaction. The asymmetry of the cavity highlights the importance of the purine–dppz–purine stacking interaction.
One‐Pot Synthesis of Co3O4/Ag Nanoparticles Supported on N‐Doped Graphene as Efficient Bifunctional Oxygen Catalysts for Flexible Rechargeable Zinc–Air Batteries
Authors: Wang Qin , Miao He , Sun Shanshan , Xue Yejian , Liu Zhaoping 
Published: August 2018

AbstractFlexible rechargeable zinc–air batteries are considered as one of the most promising power supplies for the emerging flexible and wearable electronic devices. However, the development of flexible zinc–air batteries is stagnant due to the lack of efficient bifunctional catalysts with high oxygen catalytic activity and flexible solid‐state electrolytes with high mechanical stability and ionic conductivity. In this work, Co3O4/Ag@NrGO composite was synthesized by a facile one‐pot method, and the catalyst shows remarkable oxygen reduction reaction (ORR)/oxygen evolution reaction (OER) bifunctional catalytic activity and good long‐term stability. In particular, the OER overpotential of Co3O4/Ag@NrGO reaches 437 mV, outperforming that of the commercial IrO2 catalyst. This can be attributed to the combined effects of Co3O4, Ag, and N‐rGO. Furthermore, PAA (polyacrylic acid) and PVA (polyvinyl alcohol) based gel‐electrolytes have been developed as flexible solid‐state electrolytes for zinc–air batteries. The results show that PAA‐based electrolyte is more favorable to the flexible zinc–air battery with a high power density due to its relatively high ionic conductivity. The maximum power density of flexible zinc–air batteries with Co3O4/Ag@NrGO catalyst and PAA‐based electrolyte can reach 108 mW cm−2, which is almost the highest value reached in recent reports. This work will provide valuable guidance for the development of flexible rechargeable zinc–air batteries with high power density and stability.
Facet Effects of Ag3PO4 on Charge‐Carrier Dynamics: Trade‐Off Between Photocatalytic Activity and Charge‐Carrier Lifetime
Authors: Kim Sooyeon , Wang Yue , Zhu Mingshan , Fujitsuka Mamoru , Majima Tetsuro 
Published: August 2018

AbstractSilver phosphate (Ag3PO4) is a promising visible‐light‐driven photocatalyst with a strong oxidation power and exceptionally high apparent quantum yield of O2 evolution. Although engineering Ag3PO4 facets is widely known to enhance its photocatalytic activity, most studies have explained its facet effect by calculating surface energies. Herein, the charge carrier dynamics in three kinds of Ag3PO4 crystals (mixed facets, cubic, and tetrahedral structures) were first investigated using single‐particle photoluminescence microscopy and femtosecond time‐resolved diffuse reflectance spectroscopy. As a result, we clarified that the disagreement between the photocatalytic activities (dye degradation and O2 evolution) of different Ag3PO4 facets are the consequence of trade‐off between catalytic activity and lifetime of photogenerated charge carriers in addition to surface energy.
A Randomized, Double‐Blind, Single‐Dose, Crossover Study to Demonstrate the Bioequivalence of 2 Formulations of Albiglutide in Healthy Adult Participants
Authors: Shaddinger Bonnie C. , Vlasakakis Georgios , Soffer Joseph , Thorpe Karl M. , Hatch Daniel , Nino Antonio J. 
Published: August 2018

AbstractAlbiglutide, developed for treatment of type 2 diabetes mellitus, is provided in a dual‐chamber cartridge (DCC) single‐dose pen‐injector containing lyophilized drug that must be reconstituted with diluent prior to use. A liquid formulation of albiglutide has been developed that does not require mixing. In this 2‐period, randomized, crossover, double‐blind, phase I study (NCT02660736) in 59 healthy volunteers, pharmacokinetic parameters were determined and the bioequivalence of the 2 formulations was assessed. Participants received injections from each type of pen‐injector, one containing albiglutide 50 mg and one containing placebo, followed by an 8‐week washout period between regimens: albiglutide 50‐mg liquid formulation from an auto‐injector and lyophilized placebo from a DCC pen‐injector (Regimen A), or placebo liquid from an auto‐injector and lyophilized albiglutide 50 mg from a DCC pen‐injector (Regimen B). Geometric mean total exposures (area under the drug concentration–time curve [AUC](0‐t) [1345.4 vs 1426.9 (μg · h/mL)], AUC(0‐∞) [1376.2 vs 1454.6 (μg · h/mL)], and maximum concentration of drug in blood plasma [4968.5 vs 5314.7 ng/mL]) were comparable between Regimens A and B. Ratios of geometric least square means (90% confidence interval) were 95.3% (89.49‐101.52) for AUC(0‐∞), 95.1% (89.12‐101.49) for AUC(0‐t), and 93.2% (86.76‐100.17) for maximum concentration of drug in blood plasma, falling within the 90% confidence interval of 0.80 to 1.25 for bioequivalence. No new safety concerns were observed.
A speculation‐friendly binary search tree
Authors: Crain Tyler , Gramoli Vincent , Raynal Michel 
Published: August 2018

SummaryWe introduce the first concurrent data structure algorithm designed for speculative executions. Prior to this work, concurrent structures were mainly designed for their pessimistic (non‐speculative) accesses to have a predictable asymptotic complexity. Researchers tried to evaluate transactional memory using such structures whose prominent example is the red‐black tree library developed by Oracle Labs that is part of multiple benchmark distributions. Although well‐engineered, such structures remain badly suited for speculative accesses, whose step complexity might raise dramatically with contention. We propose a binary search tree data structure whose key novelty stems from the decoupling of update operations, ie, instead of performing an update operation in a single large transaction, it is split into one transaction that modifies the abstraction state and several other transactions that restructure the tree implementation in the background. This results in a speculation‐friendly tree (s‐tree) that outperforms previous HTM‐based and STM‐based trees by being transiently unbalanced during contention peaks and by rebalancing in quadratic time when contention disappears. In particular, the s‐tree is shown correct, reusable, and speeds up a transaction‐based travel reservation application by up to 3.5×.
Acquiring High‐Performance and Stable Mixed‐Dimensional Perovskite Solar Cells by Using a Transition‐Metal‐Substituted Pb Precursor
Authors: Zheng Haiying , Liu Guozhen , Xu Xiaoxiao , Alsaedi Ahmed , Hayat Tasawar , Pan Xu , Dai Songyuan 
Published: August 2018

AbstractIn recent years, as the most promising photovoltaic technology, lead halide perovskite solar cells (PSCs) have become a research hotspot owing to their super‐high power conversion efficiency (PCE) and simple preparation method. However, the toxicity of lead and instability under high humidity and temperature greatly affects their further development. In this study, we investigated three kinds of non‐toxic transition metal cations (Zn2+, Mn2+, and Ni2+) at 3 % to partially substitute lead cations and form mixed‐dimensional (MD) perovskites. Among these transition metals, Zn2+ is the most suitable to replace Pb2+ and Zn‐MD perovskite device exhibits the best PCE of 18.35 %. In addition, we further studied the humidity and heat stability of methylammonium lead iodide (MA), Zn‐MD, Mn‐MD, and Ni‐MD perovskite devices. Upon exposure to about 50 % relativity humidity (RH) for 800 h, the MA and three MD devices, respectively, maintain 30 %, 81 %, 80 %, and 74 % of their original PCE. After aging at 60 °C for 100 h, the PCEs of the four PSCs retain 40 %, 84 %, 85 %, and 76 % of their starting values, respectively. The results show that the three MD perovskite devices have high humidity and heat stability and using transition‐metal‐substituted Pb can gain long‐term stability and reduced toxicity of PSCs.
Research on oblivious keyword search protocols with CKA security
Authors: Jiang ZhengTao , Liu Ling , Pang LiaoJun 
Published: August 2018

SummaryAn oblivious keyword search (OKS) protocol allows a user to search and retrieve the data associated with a chosen keyword in an oblivious way. It has stronger security attributes than traditional searchable encryption schemes which suffer from keyword guessing attack. Whereas most of the existing OKS protocols are not satisfactory because they mainly have the following flaws: (1) Large ciphertext‐size, relatively low communication, and computation efficiency; (2) Do not protect both user and database's privacy simultaneity. To deal with the above two problems and to obtain strong privacy, we investigate new approaches to design efficient OKS protocols. Our OKS protocol mainly realizes three contributions: (1) Improving privacy for both users and database servers; (2) Realizing compact cipher‐size; and (3) Overcoming particular security flaws occurred in previous OKS protocols.To prove what precise security can be expected in our OKS protocol, a formal chosen keyword attack model is defined to incorporate real attackers' abilities. Chosen keyword attack model is also utilized to analyze and point out security flaws in current OKS protocols. Efficiency and security comparison with existing OKS protocols is described to indicate their appropriate applications.
Visceral adiposity index as a useful tool for the assessment of cardiometabolic disease risk in women aged 65 to 74
Authors: Dereziński Tadeusz , Zozulińska‐Ziółkiewicz Dorota , Uruska Aleksandra , Dąbrowski Mariusz 
Published: August 2018

AbstractBackgroundThe visceral adiposity index (VAI) is considered to be a reliable indicator of adipose tissue dysfunction and cardiometabolic disease risk. The aim of this study was to evaluate its usefulness in assessing cardiometabolic risk in a sample of elderly women living in a rural‐urban community in central Poland.MethodsA total of 365 women aged 65 to 74 years were included in this cross‐sectional study. All patients were interviewed to obtain their history of diabetes mellitus, myocardial infarction, stroke, and revascularization. For all participants, anthropometric measurements were performed, then body mass index (BMI) and waist/hip ratio were calculated. Blood pressure was measured on the arm and on both ankles, and the ankle/brachial index was calculated. Blood samples were collected for the assessment of glycemia, lipid profile, and creatinine level. In patients with elevated fasting glucose, the test was repeated, or an oral glucose tolerance test was performed where appropriate. Finally, carotid intima‐media thickness was measured in all women.ResultsThe VAI of participants was significantly correlated with a history of myocardial infarction, higher carotid intima‐media thickness, diabetes, prediabetes, and impaired kidney function. Furthermore, VAI demonstrated a better correlation with these endpoints than BMI or waist circumference.ConclusionsThe VAI can be considered a useful tool for the assessment of cardiometabolic disease risk in elderly women, with a score of ≥2.71 representing the cut‐off point for identifying females at high risk. In such patients, screening for cardiovascular disease, abnormal glucose metabolism, and impaired kidney function should be routine practice.
Minimally important difference and predictors of change in quality of life in type 2 diabetes: A community‐based survey in China
Authors: Jin Xuejing , Liu Gordon G. , Gerstein Hertzel C. , Levine Mitchell A.H. , Guan Haijing , Li Hongchao , Xie Feng 
Published: August 2018

AbstractBackgroundTo identify the minimally important difference (MID) of the EQ‐5D‐3L and determinants of change in quality of life (QoL) as measured by the EQ‐5D‐3L over 1 year for Chinese type 2 diabetic patients (T2DPs).MethodsClinically diagnosed T2DPs were recruited from 66 community health centres in five Chinese cities using a multistage quota sampling method between December 2010 and October 2011. Demographics, diabetes‐related information, and health‐related behaviours were collected at baseline. The EQ‐5D‐3L was administered at baseline and at 12 months. Anchor‐based and distribution‐based approaches were employed to estimate MIDs. Using the MIDs as cut‐points, we identified the change in EQ‐5D‐3L‐measured QoL into “worsening,” “no change,” and “bettering.” Logistic and ordered logistic regressions were conducted for those who reported best possible EQ‐5D health state (“best possible HS”) and impaired EQ‐5D health states (“impaired HS”) at baseline, respectively. Explanatory variables included demographics, diabetes‐related information, and health‐related behaviours.ResultsA total of 1958 patients (54.9% female, mean age 61.2 years, mean diabetes duration 7.9 years) were included in our analysis. MIDs of the EQ‐5D‐3L for deterioration and improvement were estimated as −0.066 to −0.003, and 0.049 to 0.077, respectively. For the impaired HS group, older age, lower education, and less exercise were significant predictors for worsening in QoL; whereas, those predictors were older age, female gender, and lower income for the best possible HS group.ConclusionsMinimally important differences for deterioration and improvement were estimated for the EQ‐5D‐3L. Age, gender, education, income, and exercise were significant determinants of QoL change for Chinese T2DPs.