bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression Profiling of Blood microRNAs 885, 361, and 17 in the Patients with the Parkinson’s disease: Integrating Interaction Data to Uncover the Possible Triggering Age-Related Mechanisms
Authors: Behbahanipour Molood , Peymani Maryam , Salari Mehri , Hashemi Motahare-Sadat , Nasr-Esfahani Mohammad Hossein , Ghaedi Kamran 
Published: September 2019

AbstractMicroRNAs (miRNAs) have been reported to contribute to the pathophysiology of the Parkinson’s disease (PD), an age related-neurodegenerative disorder. The aim of present study was to compare the expression profiles of a new set of candidate miRNAs related to aging and cellular senescence in peripheral blood mononuclear cells (PBMCs) obtained from the PD patients with healthy controls and then in the early and advanced stages of the PD patients with their controls to clarify whether their expression was correlated with the disease severity. We have also proposed a consensus-based strategy to interpret the miRNAs expression data to gain a better insight into the molecular regulatory alterations during the incidence of PD. We evaluated the miRNA expression levels in the PBMCs obtained from 36 patients with PD and 16 healthy controls by the reverse transcription-quantitative real-time PCR and their performance to discriminate the PD patients from the healthy subjects assessed using the receiver operating characteristic curve analysis. Also, we applied our consensus and integration approach to construct a deregulated miRNA-based network in PD with the respective targets and transcription factors, and the enriched gene ontology and pathways using the enrichment analysis approach were obtained. There was a significant overexpression of miR-885 and miR-17 and the downregulation of miR-361 in the PD patients compared to the controls. The blood expression of miR-885 and miR-17 tended to increase along with the disease severity. On the other hand, the lower levels of miR-361 in the early stages of the PD patients, as compared to controls, and its higher levels in the advanced stages of PD patients, as compared to the early stages of the PD patients, were observed. Combination of all three miRNAs showed an appropriate value of AUC (0.985) to discriminate the PD patients from the healthy subjects. Also, the deregulated miRNAs were linked to the known PD pathways and the candidate related target genes were presented. We revealed 3 candidate biomarkers related to aging and cellular senescence for the first time in the patients with PD. Our in-silico analysis identified candidate target genes and TFs, including those related to neurodegeneration and PD. Overall, our findings provided novel insights into the probable age-regulatory mechanisms underlying PD and a rationale to further clarify the role of the identified miRNAs in the PD pathogenesis.
Polariton hyperspectral imaging of two-dimensional semiconductor crystals
Authors: Gebhardt Christian , Förg Michael , Yamaguchi Hisato , Bilgin Ismail , Mohite Aditya D. , Gies Christopher , Florian Matthias , Hartmann Malte , Hänsch Theodor W. , Högele Alexander , Hunger David 
Published: September 2019

AbstractAtomically thin crystals of transition metal dichalcogenides (TMDs) host excitons with strong binding energies and sizable light-matter interactions. Coupled to optical cavities, monolayer TMDs routinely reach the regime of strong light-matter coupling, where excitons and photons admix coherently to form polaritons up to room temperature. Here, we explore the two-dimensional nature of TMD polaritons with scanning-cavity hyperspectral imaging. We record a spatial map of polariton properties of extended WS2 monolayers coupled to a tunable micro cavity in the strong coupling regime, and correlate it with maps of exciton extinction and fluorescence taken from the same flake with the cavity. We find a high level of homogeneity, and show that polariton splitting variations are correlated with intrinsic exciton properties such as oscillator strength and linewidth. Moreover, we observe a deviation from thermal equilibrium in the resonant polariton population, which we ascribe to non-Markovian polariton-phonon coupling. Our measurements reveal a promisingly consistent polariton landscape, and highlight the importance of phonons for future polaritonic devices.
The human long non-coding RNA gene RMRP has pleiotropic effects and regulates cell-cycle progression at G2
Authors: Vakkilainen Svetlana , Skoog Tiina , Einarsdottir Elisabet , Middleton Anna , Pekkinen Minna , Öhman Tiina , Katayama Shintaro , Krjutškov Kaarel , Kovanen Panu E. , Varjosalo Markku , Lindqvist Arne , Kere Juha , Mäkitie Outi 
Published: September 2019

AbstractRMRPwas the first non-coding nuclear RNA gene implicated in a disease. Its mutations cause cartilage-hair hypoplasia (CHH), an autosomal recessive skeletal dysplasia with growth failure, immunodeficiency, and a high risk for malignancies. This study aimed to gain further insight into the role of RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) in cellular physiology and disease pathogenesis. We combined transcriptome analysis with single-cell analysis using fibroblasts from CHH patients and healthy controls. To directly assess cell cycle progression, we followed CHH fibroblasts by pulse-labeling and time-lapse microscopy. Transcriptome analysis identified 35 significantly upregulated and 130 downregulated genes in CHH fibroblasts. The downregulated genes were significantly connected to the cell cycle. Multiple other pathways, involving regulation of apoptosis, bone and cartilage formation, and lymphocyte function, were also affected, as well as PI3K-Akt signaling. Cell-cycle studies indicated that the CHH cells were delayed specifically in the passage from G2 phase to mitosis. Our findings expand the mechanistic understanding of CHH, indicate possible pathways for therapeutic intervention and add to the limited understanding of the functions ofRMRP.
Digital soil mapping including additional point sampling in Posses ecosystem services pilot watershed, southeastern Brazil
Authors: Silva Bárbara Pereira Christofaro , Silva Marx Leandro Naves , Avalos Fabio Arnaldo Pomar , de Menezes Michele Duarte , Curi Nilton 
Published: September 2019

AbstractThis study aimed to evaluate the performance of three spatial association models used in digital soil mapping and the effects of additional point sampling in a steep-slope watershed (1,200 ha). A soil survey was carried out and 74 soil profiles were analyzed. The tested models were: Multinomial logistic regression (MLR), C5 decision tree (C5-DT) and Random forest (RF). In order to reduce the effects of an imbalanced dataset on the accuracy of the tested models, additional sampling retrieved by photointerpretation was necessary. Accuracy assessment was based on aggregated data from a proportional 5-fold cross-validation procedure. Extrapolation assessment was based on the multivariate environmental similarity surface (MESS). The RF model including additional sampling (RF*) showed the best performance among the tested models (overall accuracy = 49%, kappa index = 0.33). The RF* allowed to link soil mapping units (SMU) and, in the case of less-common soil classes in the watershed, to set specific conditions of occurrence on the space of terrain-attributes. MESS analysis showed reliable outputs for 82.5% of the watershed. SMU distribution across the watershed was: Typic Rhodudult (56%), Typic Hapludult* (13%), Typic Dystrudept (10%), Typic Endoaquent + Fluventic Dystrudept (10%), Typic Hapludult (9.5%) and Rhodic Hapludox + Typic Hapludox (2%).
Data Driven Investigation of Bispectral Index Algorithm
Authors: Lee Hyung-Chul , Ryu Ho-Geol , Park Yoonsang , Yoon Soo Bin , Yang Seong Mi , Oh Hye-Won , Jung Chul-Woo 
Published: September 2019

AbstractBispectral index (BIS), a useful marker of anaesthetic depth, is calculated by a statistical multivariate model using nonlinear functions of electroencephalography-based subparameters. However, only a portion of the proprietary algorithm has been identified. We investigated the BIS algorithm using clinical big data and machine learning techniques. Retrospective data from 5,427 patients who underwent BIS monitoring during general anaesthesia were used, of which 80% and 20% were used as training datasets and test datasets, respectively. A histogram of data points was plotted to define five BIS ranges representing the depth of anaesthesia. Decision tree analysis was performed to determine the electroencephalography subparameters and their thresholds for classifying five BIS ranges. Random sample consensus regression analyses were performed using the subparameters to derive multiple linear regression models of BIS calculation in five BIS ranges. The performance of the decision tree and regression models was externally validated with positive predictive value and median absolute error, respectively. A four-level depth decision tree was built with four subparameters such as burst suppression ratio, power of electromyogram, 95% spectral edge frequency, and relative beta ratio. Positive predictive values were 100%, 80%, 80%, 85% and 89% in the order of increasing BIS in the five BIS ranges. The average of median absolute errors of regression models was 4.1 as BIS value. A data driven BIS calculation algorithm using multiple electroencephalography subparameters with different weights depending on BIS ranges has been proposed. The results may help the anaesthesiologists interpret the erroneous BIS values observed during clinical practice.
Diagnostic and Prognostic Value of Soluble Urokinase-type Plasminogen Activator Receptor (suPAR) in Focal Segmental Glomerulosclerosis and Impact of Detection Method
Authors: Winnicki Wolfgang , Sunder-Plassmann Gere , Sengölge Gürkan , Handisurya Ammon , Herkner Harald , Kornauth Christoph , Bielesz Bernhard , Wagner Ludwig , Kikić Željko , Pajenda Sahra , Reiter Thomas , Schairer Benjamin , Schmidt Alice 
Published: September 2019

AbstractThe plasma soluble urokinase-type plasminogen activator receptor (suPAR) is a biomarker for focal segmental glomerulosclerosis (FSGS), but its value is under discussion because of ambiguous results arising from different ELISA methods in previous studies. The aim of this study was to compare diagnostic performance of two leading suPAR ELISA kits and examine four objectives in 146 subjects: (1) plasma suPAR levels according to glomerular disease (primary, secondary and recurrent FSGS after kidney transplantation, other glomerulonephritis) and in healthy controls; (2) suPAR levels based on glomerular filtration rate; (3) sensitivity and specificity of suPAR for FSGS diagnosis and determination of optimal cut-offs; (4) suPAR as prognostic tool. Patients with FSGS showed significant higher suPAR values than patients with other glomerulonephritis and healthy individuals. This applied to subjects with and without chronic kidney disease. Although both suPARnostic™ assay and Quantikine Human uPAR ELISA Kit exerted high sensitivity and specificity for FSGS diagnosis, their cut-off values of 4.644 ng/mL and 2.789 ng/mL were significantly different. Higher suPAR was furthermore predictive for progression to end-stage renal disease. In summary, suPAR values must be interpreted in the context of population and test methods used. Knowing test specific cut-offs makes suPAR a valuable biomarker for FSGS.
Dense gas formation and destruction in a simulated Perseus-like galaxy cluster with spin-driven black hole feedback
Authors: Beckmann R. S. , Dubois Y. , Guillard P. , Salome P. , Olivares V. , Polles F. , Cadiou C. , Combes F. , Hamer S. , Lehnert M. D. , Pineau des Forets G. 
Published: September 2019

Context.Extended filamentary Hαemission nebulae are a striking feature of nearby galaxy clusters but the formation mechanism of the filaments, and the processes which shape their morphology remain unclear.Aims.We conduct an investigation into the formation, evolution and destruction of dense gas in the centre of a simulated, Perseus-like, cluster under the influence of a spin-driven jet. The jet is powered by the supermassive black hole (SMBH) located in the cluster’s brightest cluster galaxy. We particularly study the role played by condensation of dense gas from the diffuse intracluster medium, and the impact of direct uplifting of existing dense gas by the jets, in determining the spatial distribution and kinematics of the dense gas.Methods.We present a hydrodynamical simulation of an idealised Perseus-like cluster using the adaptive mesh refinement codeRAMSES. Our simulation includes a SMBH that self-consistently tracks its spin evolution via its local accretion, and in turn drives a large-scale jet whose direction is based on the black hole’s spin evolution. The simulation also includes a live dark matter (DM) halo, a SMBH free to move in the DM potential, star formation and stellar feedback.Results.We show that the formation and destruction of dense gas is closely linked to the SMBH’s feedback cycle, and that its morphology is highly variable throughout the simulation. While extended filamentary structures readily condense from the hot intra-cluster medium, they are easily shattered into an overly clumpy distribution of gas during their interaction with the jet driven outflows. Condensation occurs predominantly onto infalling gas located 5−15 kpc from the centre during quiescent phases of the central AGN, when the local ratio of the cooling time to free fall time falls below 20, i.e. whentcool/tff <  20.Conclusions.We find evidence for both condensation and uplifting of dense gas, but caution that purely hydrodynamical simulations struggle to effectively regulate the cluster cooling cycle and produce overly clumpy distributions of dense gas morphologies, compared to observation.
Transfer Hydration of Dinitriles to Dicarboxamides
Authors: Naraoka Asuka , Naka Hiroshi 
Published: September 2019

We present a robust method for double transfer hydration of dinitriles to afford diamides. The transfer hydration of 1,n-dinitriles (n = 1–6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.
Acute Renal Infection in Adult, Part 1: An Overview of What the Radiologist Needs to Know
Authors: Hazarika Suman , Venkataramanan Rochita , Das Tonmoy , Deuri Sukanya , Lohchab Shalini , Rongpipi Tamsir , Agarwala Asish , Venkataramanan Akash 
Published: September 2019

AbstractAcute renal infection or acute pyelonephritis (AP) denotes the process of inflammation of the renal parenchyma and its collecting system and the urothelium following infection. Uncomplicated AP commonly affects otherwise healthy, young women without structural or functional urinary tract abnormalities and without relevant comorbidities. More severe and complicated AP occurs in patients with a structurally or functionally abnormal genitourinary tract, or in persons with a predisposing medical condition like immune compromised state and diabetes. Complicated AP is characterized by a broader spectrum of clinical presentations, a wider variety of infecting organisms, and a greater risk of progression to a complication, such as intrarenal or perinephric abscess or emphysematous pyelonephritis and has the capacity to damage the organ and at times maybe life threatening. Role of imaging in renal infection is secondary, and in most situations, imaging is done to confirm the clinical diagnosis, map progression of disease in immune-compromised group of patients, or to evaluate for potential complications and therapeutic interventions. This article attempts to discuss the pathophysiology of AP from the standpoint of medical imaging and also brings out illustrative examples of various manifestations of AP and its complications. It provides imaging insight into various stages of inflammation, development of complication, and a roadmap for understanding AP through cross-sectional imaging.
Effectiveness and Safety of Isoxsuprine Hydrochloride as Tocolytic Agent in Arresting Active/Threatened Preterm Labor and Its Role in Maintenance Tocolysis: A Prospective, Open-Label Study
Authors: Jaju Purushottam B. 
Published: September 2019

Abstract
Objective The aim of the study is to obtain insights on the short and long-term safety and effectiveness of isoxsuprine hydrochloride as a tocolytic agent in the management of PTL.
Study Design In this prospective, single-center, noncomparative study, patients (with preterm labor at gestational age of 24–37 weeks) were administered intravenous (IV) infusion of 40-mg isoxsuprine hydrochloride until uterine quiescence, followed by intramuscular (IM) injection of isoxsuprine hydrochloride 10 mg/4-hourly for first 24 hours and maintained with retard 40-mg sustained release capsule (two times a day) till the time of delivery or 37 completed weeks of pregnancy.
Results All patients (n = 50) achieved successful tocolysis in 24 hours and 48 hours postadministration of isoxsuprine hydrochloride (IV/IM/oral). Mean (±SD) gestation age at the time of delivery was 39.8 ± 2.1 weeks, with latency period of 58.5 ± 18.7 days. Pregnancy outcomes were normal in all the patients and no congenital anomaly/fetal infection was reported. Mean (±SD) fetal birth weight was 2.7 ± 0.3 kg; mean (±SD) Apgar score at 1 and 5 minutes were 7.5 ± 0.6 and 9.2 ± 0.4, respectively. Maternal tachycardia and vomiting (8.0% each) were the commonly reported adverse drug reactions, which were resolved with dose adjustment.
Conclusion Isoxsuprine was found to be an effective and well-tolerated tocolytic agent in arresting PTL, in turn resulting in the overall improvement in maternal and perinatal outcomes.
RNA ligation precedes the retrotransposition of U6/LINE-1 chimeric RNA
Authors: Moldovan John B. , Wang Yifan , Shuman Stewart , Mills Ryan E. , Moran John V. 
Published: September 2019

Significance
Long interspersed element-1s (L1s) encode 2 proteins (ORF1p and ORF2p) that preferentially mobilize (i.e., retrotranspose) their encoding messenger RNA (mRNA) transcript. ORF1p and/or ORF2p can also mobilize other cellular RNAs, including short interspersed elements (SINEs), U6 small nuclear RNA (snRNA), and mRNAs. Here, we demonstrate the RNA ligase RtcB can join U6 snRNA to L1 or other cellular RNAs to create chimeric RNAs; retrotransposition of the resultant chimeric RNAs leads to chimeric pseudogene formation; and chimeric U6/L1 RNAs are part of the transcriptome in multiple human cells. These data suggest RNA ligation contributes to the plasticity of the transcriptome and that the retrotransposition of chimeric RNAs can generate genetic variation in the human genome.
Propinquity drives the emergence of network structure and density
Authors: Gallos Lazaros K. , Havlin Shlomo , Stanley H. Eugene , Fefferman Nina H. 
Published: September 2019

Significance
While many studies have focused on how new nodes make connections as they enter a network, we instead consider how choices of additional neighbors, after initial introduction, can shape patterns in emergent network structure. We find the footprints of this type of emergence in real-world networks and discuss how one could estimate the processes driving topology by examination of static snapshots of networks through the lens of link density. Our approach yields insight into network formation in applications ranging from social behavior to drug discovery.
Crystal growth kinetics as an architectural constraint on the evolution of molluscan shells
Authors: Schoeppler Vanessa , Lemanis Robert , Reich Elke , Pusztai Tamás , Gránásy László , Zlotnikov Igor 
Published: September 2019

SignificanceUsing notions from classic materials science, we expand our understanding of the macroscopic morphospace of possible molluscan shell shapes to the level of possible ultrastructures that comprise them. This provides us with a unique opportunity to explore this morphospace using well-developed analytical, theoretical, and numerical tools and to test the effects of a discrete number of parameters on shell biomineralization. The physical model presented here sheds a new light on the evolutionary aspect of molluscan shell ultrastructural fabrication and suggests that the repeated “discovery” of some mineral morphologies partially reflects a series of architectural constraints provided by biomineral growth kinetics.
Scalar current limit from the beta-neutrino correlation: the WISArD experiment
Authors: Araujo-Escalona V. , Alfaurt P. , Ascher P. , Atanasov D. , Blank B. , Daudin L. , Fléchard X. , Gerbaux M. , Giovinazzo J. , Grévy S. , Kurtukian Nieto T. , Liénard E. , Nies L. , Quéméner G. , Roche M. , Severijns N. , Vanlangendonck S. , Versteegen M. , Wagenknecht P. , Zakoucky D. 
Published: September 2019

Abstract
Beta - neutrino correlation measurements are key in the research of physics beyond the Standard Model. In pure Fermi beta transitions, the beta-neutrino correlation coefficient, a
βν, is sensitive to the presence of scalar currents. The present limits were established by experimental studies of various nuclear systems with allowed Fermi transitions. A new experiment to improve the constraints on scalar currents is being developed, by the WISArD collaboration at ISOLDE/CERN, where the aim is to measure the energy shift of the β-delayed protons emitted from the isobaric analogue state of the 32Ar ground state. To enhance the sensitivity, protons and positrons are guided by a strong magnetic field and measured in coincidence between the two detection configurations located on both sides of a catcher foil in which the radioactive samples are implanted. Kinematic energy shifts of the protons in coincidence with positrons, in the same or opposite hemisphere of the catcher foil, will be more or less pronounced as a function of the possible scalar current component of the weak interaction. Details of the apparatus and preliminary results of the experiment are presented.
Study of the 32S(3He,d)33Cl one-proton transfer reaction with a new generation hodoscope
Authors: Cinausero M , Dell’Aquila D , Lombardo I , Vigilante M , Barlini S , Bolzonella R , Bruno M , Buccola A , Cartuan S , Casini G , Cicerchia M , D’Andrea M , Degerlier M , Fabris D , Gasques L , Gramegna F , Lepine-Szily A , Mantovani G , Marchi T , Piantelli S , Rigato V , Scomparin L , Valdrè S 
Published: September 2019

Abstract
The 32S(3He,d)33Cl one-proton transfer reaction is a powerful tool to investigate the spectroscopy of low-lying states in the proton-rich 33Cl nucleus. However, the extraction of firm differential cross-section data at various angles, against which benchmarking theoretical models to correctly constrain the spectroscopy of 33Cl, is made challenging by the presence of competitive reaction products contaminating the detected energy spectra. We have recently measured the 32S(3He,d)33Cl reaction at 9.8 MeV incident energy by using a new generation hodoscope of silicon detectors, capable to detect and identify emitted deuterons down to energies of the order of 2 MeV. The high angular segmentation of our hodoscope allowed to unambiguously disentangle the contribution of one-proton transfer reactions in the ground state of 33Cl and in its 0.810 MeV, 2.352 MeV, 2.685 MeV, 2.846 MeV excited states from contaminant deuteron-emitting reactions. These data will be crucial to help to constrain Jπ
and spectroscopic factor C
2
Sp
values of low-lying 33Cl states, still ambiguous in the literature. The present status of the analysis is discussed in the paper.