bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Aspects of Catechin and Its Derivatives – An Update
Authors: Coșarcă Sanda , Tanase Corneliu , Muntean Daniela Lucia 
Published: September 2019

Abstract
Catechin and its derivatives are polyphenolic benzopyran compounds. The condensation of catechin units leads to the formation of condensed tannins. It is found in appreciable amount in green tea leaves, cocoa, red wines, beer, chocolate, etc. It possesses important antioxidant, antibacterial, antifungal, antidiabetic, anti-inflammatory, antiproliferative and antitumor properties. The present review outlines recent updates and perspectives of the effects of catechins and the pharmacodynamic mechanisms involved.
NTS Targeted By miR-182 Modulates the Apoptosis of Goat Endometrial Epithelial Cells
Authors: Xiaopeng An , Yue Zhang , Jidan Liu , Xingna Ma , Zhaoyu Guo , Binyun Cao 
Published: September 2019

Abstract
Neurotensin is a tridecapeptide that functions in prenatal metabolism. It is targeted and downregulated by miR-182 through binding the seed site of miR-182 to the 3′ untranslated region and reduced by a candidate tumor suppressor, testin. Considering that apoptosis is critical in the development of mammalian preattachment embryos, this study investigated the modulation of neurotensin to the apoptosis of goat endometrial epithelial cells and apoptosis-related proteins (P38 MAPK and caspase8). Results showed that Neurotensin resisted the apoptosis of goat endometrial epithelial cells through the caspase8 pathway and activated the phosphorylation of P38 MAPK, which is involved in blastocyst formation. Thus, miR-182 is likely to promote uterus health by targeting Neurotensin and upregulating Testin.
The Myth of Austerity. Empirical Evidence from the Eurozone Countries
Authors: Wildowicz-Giegiel Anna 
Published: September 2019

Abstract
The paper discusses the impact of austerity policy on economic performance in the eurozone countries after the global crisis that occurred in 2007-08. The undertaken fiscal consolidation efforts to cut government expenditure and increase government taxes which begun in 2010, aimed to return sustainability in public finance as the rapid growth in sovereign debt was observed in many economies, especially in the South Europe. The implemented austerity policy under the external pressure not only amplified recession but also caused the further deterioration of public finance characterized by large deficits and increasing public debt. Based on the literature and empirical findings, the issue of austerity policy and its potential consequences on growth is examined. The research aim is to explore both advantages and disadvantages of austerity, focusing on the macroeconomic conditions which accompanied it and the impact of such policy on economic growth in the eurozone countries. The hypothesis of the negative influence of austerity on economic performance is verified on the basis of recent economic literature and conducted empirical research. Both descriptive analysis and dynamic panel regression based on two-step Generalized Method of Moments was used. Data from 2010-17 for the eurozone countries served to prove the existence of a key negative relationship between austerity policy and economic growth in economies that experienced deep great recession. The conducted analysis confirmed that austerity initiated to reduce the public debt to GDP doesn’t contribute to macroeconomic stabilization, adversely affecting potential output. Contrary to widely held opinion, this allows us to claim that austerity is not a good remedy for economies suffering from recession.
Prevalence of alexithymia among a cohort of well controlled HIV-infected adolescents and non-HIV-infected adolescents
Authors: Gurupriya M. Monica , Iyer Kiran , Kumar P. D. Madan 
Published: September 2019

Background:
With the introduction of highly active antiretroviral therapy (HAART) in 1996, the quality of life of people living with HIV has improved. Although people diagnosed and living with HIV are overwhelmed by emotions, we found that various emotional manifestations are understudied within this group of patients. One such aspect is alexithymia which is seen at exorbitantly high rates among patients with depression, causing a major public health concern. In our study, we hypothesized that clinically significant changes with HAART would be associated with changes in depression, anxiety, and alexithymia.

Materials and Methods:
A cross-sectional study was conducted with a convenient sample of 44 HIV-seropositive children and 30 healthy school children of age 12–15 years. We obtained permission from participants to access their medical records to obtain data regarding their CD4 cell counts and viral loads over the entire study period. The enrolled participants were administered a validated 20-item Toronto alexithymia scale (TAS-20) to assess their alexithymic levels.

Results:
Mean alexithymia score of healthy children was 0.67 ± 1.26 and mean of children living with HIV was 4.48 ± 7.80. When comparing the TAS-20 scores of children living with HIV and healthy children, children living with HIV revealed scores slightly higher than healthy children, but none showed scores equal to 40. There was statistically significant difference between both groups (P = 0.003).

Conclusion:
Our study revealed that there was a significant difference between the TAS scores of HIV-seropositive children on HAART and healthy children, none of their scores indicated alexithymic condition. In the health sector, alexithymia has been emphasized as barriers to patient-practitioner communication. Clinicians should be aware of the decrease in alexithymic traits among HIV subjects who are under HAART. This study highlights the benefits of the HAART era, namely the chronicity of the infection and the possibility of disease management, thus improving the mental status of such population.
Definición de Unidades Ambientales de Análisis (UAA): metodología socioeconómica para la zonificación ambiental de determinados ecosistemas marino-costeros
Authors: Ospino Sepulveda Leonardo Javier , López Rodríguez Angela Cecilia 
Published: September 2019

The purpose of environmental zoning is to improve environmental management and the sustainable management of the coastal and marine ecosystems. This zoning can be performed by using methods such as participative zoning, COLMIZC, and the method used in the Decision Support System (DSS) called “Software MARXAN”. The methods present advantages and disadvantages. However, they all require an input of detailed primary or secondary data, and biotic and physical information regarding the ecosystem. Thus, this study employs a method that was the result of the analysis of different methods, and that enables suitable environmental zoning of the marine-coastal ecosystem (e.g. mangroves, seagrasses, coral reef, etc.) without detailed biophysical information. Its main characteristic is the definition Environmental Units ofAnalysis (EUA), as units that have been considered as homogenous regions that can be defined from different aspects such as ecosystem size or distribution, and socioeconomic and cultural aspects (Ospino-Sepulveda et al., 2017b). Having defined the EUA, it is possible to map specific ecosystem and consider other important environmental elements, which sometimes are not considered important when using other methods. As a result of this work, 14 EUA were obtained in La Guajira and 14 EUA in Chocó for marine-coastal areas in the Colombian Caribbean. The application of socio-economic, socio-cultural and biotic criteria to EUA defined zones for protection, restoration, and development of sustainable economic activities. We hope that the method adopted in this work will, in the future, be considered as an alternative for the environmental zoning of ecosystems marine-coastal areas.
Limites e possibilidades da inclusão social pela Política Nacional de Turismo: O caso do Programa de Regionalização do Turismo
Authors: Tomazin Mariana , Beni Mário Carlos 
Published: September 2019

A presente pesquisa tem como objetivo analisar os impactos sociais sobre a qualidade das políticas públicas no campo do turismo, tendo como indicador a inclusão social e como objeto de estudo o Programa de Regionalização do Turismo – Roteiros do Brasil do Ministério do Turismo, o qual foi implementado em 2004. Para desvelar a problematização proposta sobre quais foram, no processo histórico concreto dos territórios, os impactos sociais do PRT e se sua ação indutora contribuiu para a inclusão social ou limitou-se a uma política pública restrita aos interesses de mercado, adotou-se uma abordagem qualitativa. O método utilizado na investigação foi o materialismo histórico dialético e no traçado metodológico utilizou-se da análise documental sobre o processo de regionalização do turismo entre os anos de 2004-2014. As evidências possíveis da pesquisa permitiram observar o distanciamento existente entre teoria e prática do PRT, posto que a opção ideológica adotada pelo Ministério do Turismo em relação à concepção do turismo e de desenvolvimento pelo turismo delineia-se em uma ação fragmentada, na qual tanto a comunidade, quanto as instâncias de governança são pautadas pela concepção do mercado, o que impossibilitou o impacto social emancipador por essa política pública de turismo proposta, embora em seu plano abstrato formal a teoria se apresente como uma possibilidade.
Os cantos estão arrumados. E agora, professora? O faz de conta com crianças da educação infantil
Authors: ABOUD Leila Orssolan , AZEVEDO Heloisa Helena Oliveira de 
Published: September 2019

Este artigo é resultado de pesquisa acadêmico-científica, cujo objetivo centrou-se em conhecer o que professoras sabem e como organizam as situações de faz de conta com alunos de educação infantil. Apresentamos aqui a análise dos quatro eixos temáticos que emergiram das falas das professoras que participaram da pesquisa, tomando como fundamento a teoria histórico-cultural. Conclui-se que as professoras possuem conhecimentos gerais sobre a importância do faz de conta, acreditam que a diversidade de brinquedos garante a brincadeira, e que a ressignificação deles na escola deve apoiar-se na formação continuada, com foco na mediação docente para a promoção do desenvolvimento psíquico.
PEMBELAJARAN IPA PADA PENDIDIKAN ANAK USIA DINI (Studi Kasus di RA Plus Ja-alHaq Kota Bengkulu)
Authors: Latipah Nurlia 
Published: September 2019

Penelitian ini bertujuan untuk mengetahui materi Ilmu Pengetahuan Alam (IPA) apa saja yang terdapat pada kurikulum RA Plus Ja-alHaq, kegiatan-kegiatan apa saja yang dilakukan untuk menyampaikan materi-materi IPA tersebut, serta teori-teori apa yang mendukung dilakukannya kegiatan-kegiatan tersebut. Hasil penelitian menunjukkan bahwa terdapat 6 Kompetensi Dasar pada KI-3 dan 6 Kompetensi Dasar pada KI-4 yang menunjukkan materi bermuatan IPA pada kurikulum RA Plus Ja-alHaq. Materi-materi IPA tersebut diajarkan melalui beberapa kelompok kegiatan yakni kegiatan mengeksplorasi berbagai benda yang ada disekitar, mengadakan berbagai percobaan sederhana, membuat hasil karya, mengkomunikasikan apa yang telah diamati dan diteliti, bernyanyi. Seluruh kegiatan tersebut dikemas dalam bentuk kegiatan bermain untuk memaksimalkan hasil yang pembelajaran. Kata Kunci : Pembelajaran IPA, PAUD
MAKNA ETIS TRADISI DOA’ PENYULUNG PADA MASYARAKAT SUKU LEMBAK DI KELURAHAN SEMARANG KOTA BENGKULU
Authors: Fikriyadi Fikriyadi 
Published: September 2019

This research is motivated by the reality in the field, there is a unique tradition done by the people of Lembak tribe in Semarang City Bengkulu City in welcoming the rice planting is the tradition of Do’a Penyulung. Researchers assume that this tradition has a religious message as well as a moral message. As the formulation of the problem in this research is the meaning of the ethical meaning of the traditions of Doul Pengulung to the people of Lembak tribe of Semarang City of Bengkulu City, how the procession of Doula Penyulung tradition in Lembur society of Semarang City of Bengkulu City, what is the meaning of symbols contained in the tradition of Do’a Penyulung In the community of Lembak urban village Semarang Bengkulu City. This research is generally aimed to know the procession of ethical meaning of Do’a Penyulung which is done annually to the people of Lembak tribe of Semarang City of Bengkulu City and to know the meaning of the symbol of Do’a Penyulung in Lembak tribe society in Semarang urban of Bengkulu City. For information in the field, the researcher uses field research type with qualitative approach. Based on the results of research and interviews conducted by researchers at the location of the research, the researchers can conclude, the ethical meaning of the tradition of Do’a Penyulung in the community of Lembak tribe in Semarang Village, Sungai Serut District Bengkulu City, raised both hands as high as Head, Head, register and head down, please permit to the chairman of the custom and the guests, right leg behind the slightly bent, local languages and national languages (Eigh Lembak Language and indonesian), wait From the chairman of customs and the organizers, the division of air siraman Which have been in prayer, gore ingredients in a jar or a particular container mixed one as much as 4 to 7 times, cover words received with regards and apologies, Pengulung includes, white and black sticky rice, Red Sugar, Coconut air and air Shrimp Acid, Jar or Bucket contains large Eros of Coconut shell, Yellow Cake, Seding leaves In and leaves of Mangosteen, leaves of Serai and Bamboo Aur yellow. All of them have a religious and sacred meaning for the people of Lembak tribe in Semarang City, Bengkulu City.
PENGAJIAN AN NAHL DI KAMPUNG PILAHAN, REJOWINANGUN, KOTAGEDE, YOGYAKARTA (1992-2012)
Authors: Fauji Sidik 
Published: September 2019

ABSTRAK Didirikannya sebuah lembaga pengajian dalam suatu masyarakat tidak lain didasari oleh sebuah kesadaran umat Islam tentang betapa pentingnya menuntut ilmu dalam kehidupan sehari-hari. Keberadaannya sangat efektif sebagai tempat dan media pembelajaran, khususnya ilmu-ilmu agama bagi kaum ibu, bapak, maupun remaja. Pengajian An Nahl yang berada di kampung Pilahan awalnya terbentuk juga sebagai wadah untuk pembelajaran ilmu-ilmu agama oleh kaum ibu-ibu. Dalam perkembangannya pengajian ini tidak hanya difokuskan pada pemberian materi-materi keagamaan tetapi mampu menciptakan perubahan- prubahan untuk mengatasi berbagai permasalahan yang dihadapi oleh jamaah maupun masyarakat. Salah satunya yaitu Pengajian An Nahl memberikan pinjaman tanpa bunga bagi masyarakat Pilahan. Penelitian ini dilaksanakan dengan tujuan untuk mendeskripsikan sejarah perkembangan Pengajian An Nahl serta kontribusinya terhadap masyarakat.Penelitian ini dipusatkan pada penelitian lapangan. Data atau sumber yang digunakan adalah arsip, hasil wawancara serta penelitian langsung di lokasi tempat pengajian. Metode yang digunakan dalam penelitian ini adalah penelitian sejarah yang dipakai untuk menyusun fakta, mendeskripsikan, dan menarik kesimpulan tentang masa lampau. Adapun kegiatan yang dilakukan dalam metode sejarah yaitu pemilihan topik, heuristik, kritik, interpretasi dan historiografi.Hasil yang diperoleh dari penelitian ini adalah deskripsi tentang Pengajian An Nahl mulai dari latar belakang didirikan hingga mengalami perkembangan. Dalam perkembangannya Pengajian An Nahl dapat dikatakan mengalami kemajuan. Hal ini dapat dilihat dari segi jumlah jamaah yang mencapai ratusan, pada awalnya pengajian ini hanya diikuti oleh delapan orang. Dari segi kualitas juga mengalami perubahan yang lebih baik. Contohnya dari cara berpakaian yang awalnya sebagian jamaah belum memakai kerudung, setelah mendapat ilmu dari Pengajian An Nahl dengan penuh kesadaran sekarang mereka mengenakannya. Selain dakwah Pengajian An Nahl juga memberikan hutang- piutang tanpa bunga dan beasiswa bagi warga Pilahan yang masih duduk di bangku SD sampai SMA.Kata kunci : Pengajian An Nahl, Perkembangan, Kontribusi.
NALAR HISTORIS PERPOLITIKAN KAUM HAWA MASA NABI MUHAMMAD SAW
Authors: Iryana Wahyu 
Published: September 2019

This paper tries to portray the role of women in the socio-political dimension in the era of the early arrival of Islam Islam is a tolerant religion that has given birth to a number of figures of brave women.. Just mention Khadijah Binti Khuwalid, Fatimah Az Zahra, Shafiyyah Binti Abdul Muthollib, Lubabah, Umul Fadhal Binti Harits, Asma Binti Amis (Wife Jafar), Fatimah Binti Khatab (Wife Said Bin Zaid), Sumayyah fighters women who sacrificed to make the nation proud and religion. For Islam, women are not only used as the secondline of life but rather, women can color the joints of life in a wider scope. So prominent is the role of women in the time of Prophet Muhammad SAW, that they were able to give up property for the glory of Islam they deserve to be called "de leidster van het verzet". Leaders of resistance like Summayah. The research method uses a descriptive approach by processing data into a writing with historical flow. The results of the study have been found that since Islam came Women have contributed to everything, starting from the economy as entrepreneurs, politicians, war fighters, housewives, and propagators of religious preaching. Tulisan ini mencoba memotret peran perempuan dalam dimensi sosial politik di era awal kedatangan Islam. Islam adalah agama toleran yang telah melahirkan sejumlah tokoh perempuan pemberani. Sebut saja Khadijah Binti Khuwalid, Fatimah Az Zahra , Shafiyyah Binti Abdul Muthollib, Lubabah, Umul Fadhal Binti Harits, Asma Binti Amis (Istri Jafar), Fatimah Binti Khatab (Istri Said Bin Zaid), Sumayyah pejuang wanita yang rela berkorban untuk mengharumkan nama Bangsa dan Agama. Bagi Islam Perempuan sesungguhnya bukan hanya dijadikan secondline kehidupan saja melainkan dari itu, Perempuan bisa mewarnai sendi-sendi kehidupan dalam cakupan yang lebih luas. Begitu menonjolnya peranan perempuan di masa Nabi Muhammad SAW., hingga mampu merelakan harta benda untuk kejayaan Islam mereka layak dsebut“de leidster van het verzet”. Pemimpin perlawanan seperti halnya Summayah. Metode penelitian menggunkan pendekatan deskriptif dengan mengolah data menjadi sebuah tulisan dengan alur historis. Hasil dari penelitian diperoleh bahwa sejak Islam datang Perempuan sudah memberikan kontribusinya di segala hal, dari mulai ekonomi sebagai pengusaha, politikus, pejuang perang, ibu rumah tangga, dan penyebar dakwah agama.
PERLAKUAN PAJAK PERTAMBAHAN NILAI (PPN) ATAS DEBIT NOTE EKSPOR JASA KENA PAJAK
Authors: Wahyudin Dian 
Published: September 2019

This study was conducted to determine about the debit notes is a taxable and tariffs 10% ( ten percent ) on export of taxable service if it is reviewed by taxable supplies, and to determine the treatment of VAT on Debit Note reviewed by the concept of destination principle and to determine whether it is acceptable in tax regulation of Indonesia if It’s issued a Debit Note for collecting of company income and to estimate how much penalties arise. This study used qualitative methods with qualitative descriptive analysis. The object of research is based on data available at the company that is secondary data. Data collection techniques are Library research.The results of data processing that the Debit Note is an taxable of VAT. In terms of destination Principle Debit Note is taxable to VAT 0 % (Zero Percent) for the shipping charge, the Minimum Order Quantity (MOQ) charge and cancel orders charge / penalty fees. Debit Note Billing mechanism is allowed in tax regulation as long as there is a document whose position equivalent to tax invoice for canceled order charge/penalty fees, but charge for shipping and the Minimum Order Quantity (MOQ) charge don’t allow in the tax regulation because it is non-compliance of the material terms of the tax invoice. As a result of the Debit Note that issued raised the sanctions of Article 14 paragraph (2) of general provisions and taxation procedures for 2 % of the tax base.Based on the suggested better in making commercial document to charge must analyze aspects of taxation in order to prevent tax penalties in this case to issue Debit Note need to create a document that is equivalent to a Tax Invoice because mechanism of the Debit Note is taxable of VAT.
COMMUNITY ODONTOLOGY AND FAMILY HEALTH STRATEGY IN DISCUSSION
Authors: FERMINO J. , CUNHA L. R. da. , LIMA R. C. G. S 
Published: September 2019

This article discusses the way how members of a family, living in a socially vulnerable community, perceive their own health and the community dental practices performed by the Family Health Strategy. The context of the study is the axis on the condition of life of the care model, as recommended by the National Policy of Buccal Health that foresees the approach of the population from their familiar universe and from the social relations experienced in the territory. It is a social study of qualitative, exploratory and descriptive approach carried out in a municipality of Santa Catarina by means of collective interview and adjusted thematic analysis. By means of the category “Bonds in a community cultural reality”, the data analysis revealed that both health and community dental practices are perceived through relations that express the subalternity, the intersubjectivity, the willingness to work, the bond with the evangelical church, life through arts, and sexual violence. The conclusion drawn is that materialization of the model of care, through the axis life conditions of the communities, requires the problematization of professional certainties generated by the hegemonic production of a technical scientism detached from the real life of vulnerable families.
Outcome of Early Laparoscopic Cholecystectomy in Acute Calculus Cholecystitis
Authors: Rahman Mohammed Masudur , Kamrunnahar - , Akter Shimul , Hossain AZM Shakhawat , Naz Fouzia Mujib Un 
Published: September 2019

Background: : The surgical management of patients presenting with acute calculus cholecystitis remains controversial.
Objective: The aim of this study was to evaluate the safety and feasibility of early laparoscopic cholecystectomy for acute calculus cholecystitis and to document the outcome of early laparoscopic cholecystectomy.
Methodology: This observational comparative study was carried out in the Department of General Surgery of Sylhet MAG Osmani Medical College Hospital, Sylhet from July 2006 to June 2008, a period of 24 months. The study group enrolled 101 patients of both sexes who underwent laparoscopic cholecystectomy surgery and divided into two groups. 51 patients with a diagnosis of acute calculus cholecystitis were assigned randomly to early laparoscopic cholecystectomy within 72 h of admission (early group, n=51) or to initial conservative treatment followed by elective laparoscopic cholecystectomy, 6 to 12 weeks later (elective group, n=50).
Results: There was no significant difference in operation times (early, 81.98 vs elective, 79.96), conversion rates (early, 5.88% vs elective 10%) or postoperative complications (early 31,4% vs elective,24%).However, during early laparoscopic cholecystectomy distended gallbladder containing infected bile was more in 41 patients (80.01%) while 04 patients (09%) and 03 patients (7.20%) in elective laparoscopic cholecystectomy (p>0.05) and significantly (p<0.05) more modification in operative techniques in early group than elective group. In addition, early group had shorte hospital stay (8.37 vs 12.62 days0 and lower treatment cost (5243.13 vs 7327) which were statistically significant (p<0.05).
Conclusion: In conclusion laparoscopic cholecystectomy during the early admission with acute calculus cholecystitis can be performed safely and successfully. Earlier surgery has a beneficial impact for patients and the National Health Service.
Journal of National Institute of Neurosciences Bangladesh, 2019;5(2): 161-166