bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paclitaxel With Inhibitor of Apoptosis Antagonist, LCL161, for Localized Triple-Negative Breast Cancer, Prospectively Stratified by Gene Signature in a Biomarker-Driven Neoadjuvant Trial
Authors: Bardia Aditya , Parton Marina , Kümmel Sherko , Estévez Laura G. , Huang Chiun-Sheng , Cortés Javier , Ruiz-Borrego Manuel , Telli Melinda L. , Martin-Martorell Paloma , López Rafael , Beck J. Thaddeus , Ismail-Khan Roohi , Chen Shin-Cheh , Hurvitz Sara A. , Mayer Ingrid A. , Carreon Daniel , Cameron Scott , Liao Serena , Baselga José , Kim Sung-Bae 
Published: September 2018

Purpose There are currently no targeted therapies approved for triple-negative breast cancer (TNBC). A tumor necrosis factor α ( TNFα)–based gene expression signature (GS) predictive of sensitivity to LCL161, inhibitor of apoptosis antagonist, was translated into a clinical assay and evaluated in a neoadjuvant trial. Patients and Methods Women with localized TNBC (T2/N0–2/M0) were prospectively stratified by GS status and randomly assigned (1:1) to receive oral LCL161 (1,800 mg once per week) and intravenous paclitaxel (80 mg/m2 once per week; combination arm) or paclitaxel alone (control arm) for 12 weeks, followed by surgery. The primary objective was to determine whether neoadjuvant LCL161 enhances efficacy of paclitaxel, defined by > 7.5% increase in the pathologic complete response (pCR, breast) rate, stratified by GS. Results Of 209 patients enrolled (207 with valid GS scores), 30.4% had GS-positive TNBC. In the GS-positive group, pCR was higher in the combination versus the control arm (38.2% v 17.2%), with 88.8% posterior probability of > 7.5% increase in pCR. However, in the GS-negative group, the pCR was lower in the combination group (5.6% v 16.4%), with 0% posterior probability of > 7.5% increase in pCR. A higher incidence of grade 3 or 4 adverse events in the combination arm included neutropenia (24.5%) and diarrhea (5.7%). Overall, 19 patients (18.1%) in the combination arm discontinued treatment because of adverse events, including pyrexia (n = 5), pneumonia (n = 4), and pneumonitis (n = 4), versus five patients (4.9%) in the control arm. Conclusion This neoadjuvant trial provides evidence supporting a biomarker-driven targeted therapy approach for selected patients with GS-positive TNBC and demonstrates the utility of a neoadjuvant trial for biomarker validation and drug development, but also highlights toxicity risk. Future neoadjuvant clinical trials should carefully weigh these considerations for targeted therapy development in biomarker-defined TNBC.
Characterization of the ventricular-subventricular stem cell niche during human brain development
Authors: Coletti Amanda M. , Singh Deepinder , Kumar Saurabh , Shafin Tasnuva Nuhat , Briody Patrick J. , Babbitt Benjamin F. , Pan Derek , Norton Emily S. , Brown Eliot C. , Kahle Kristopher T. , Del Bigio Marc R. , Conover Joanne C. 
Published: September 2018

ABSTRACT
Human brain development proceeds via a sequentially transforming stem cell population in the ventricular-subventricular zone (V-SVZ). An essential, but understudied, contributor to V-SVZ stem cell niche health is the multi-ciliated ependymal epithelium, which replaces stem cells at the ventricular surface during development. However, reorganization of the V-SVZ stem cell niche and its relationship to ependymogenesis has not been characterized in the human brain. Based on comprehensive comparative spatiotemporal analyses of cytoarchitectural changes along the mouse and human ventricle surface, we uncovered a distinctive stem cell retention pattern in humans as ependymal cells populate the surface of the ventricle in an occipital-to-frontal wave. During perinatal development, ventricle-contacting stem cells are reduced. By 7 months few stem cells are detected, paralleling the decline in neurogenesis. In adolescence and adulthood, stem cells and neurogenesis are not observed along the lateral wall. Volume, surface area and curvature of the lateral ventricles all significantly change during fetal development but stabilize after 1 year, corresponding with the wave of ependymogenesis and stem cell reduction. These findings reveal normal human V-SVZ development, highlighting the consequences of disease pathologies such as congenital hydrocephalus.
PLK4 is a microtubule-associated protein that self-assembles promoting de novo MTOC formation
Authors: Montenegro Gouveia Susana , Zitouni Sihem , Kong Dong , Duarte Paulo , Ferreira Gomes Beatriz , Sousa Ana Laura , Tranfield Erin M. , Hyman Anthony , Loncarek Jadranka , Bettencourt-Dias Monica 
Published: September 2018

ABSTRACT
The centrosome is an important microtubule-organising centre (MTOC) in animal cells. It consists of two barrel-shaped structures, the centrioles, surrounded by the pericentriolar material (PCM), which nucleates microtubules. Centrosomes can form close to an existing structure (canonical duplication) or de novo. How centrosomes form de novo is not known. The master driver of centrosome biogenesis, PLK4, is critical for the recruitment of several centriole components. Here, we investigate the beginning of centrosome biogenesis, taking advantage of Xenopus egg extracts, where PLK4 can induce de novo MTOC formation (Eckerdt et al., 2011; Zitouni et al., 2016). Surprisingly, we observe that in vitro, PLK4 can self-assemble into condensates that recruit α- and β-tubulins. In Xenopus extracts, PLK4 assemblies additionally recruit STIL, a substrate of PLK4, and the microtubule nucleator γ-tubulin, forming acentriolar MTOCs de novo. The assembly of these robust microtubule asters is independent of dynein, similar to what is found for centrosomes. We suggest a new mechanism of action for PLK4, where it forms a self-organising catalytic scaffold that recruits centriole components, PCM factors and α- and β-tubulins, leading to MTOC formation.
This article has an associated First Person interview with the first author of the paper.
Discovery and description of the first human Retro-Giant virus
Authors: Lusi Elena Angela , Caicci Federico 
Published: September 2018

Background:Robert Gallo reported the first human retrovirus HLTV in 1980. What we report here is the first human giant virus, Mimivirus-like, with a retroviral core.Methods: The isolation of human giant viruses from human T cells Leukaemia was performed on 25% sucrose gradient. The purified viral pellet was examined using electron microscopy (EM), after immunolabelling with anti-FeLV gag p27 moAb, used for its ability to bind conserved epitopes among different mammalian retroviruses. These human giant viruses were tested for reverse transcriptase activity. RNA extracted from the viral particles was initially amplified with the Pan Retrovirus PCR technique. In addition,a shotgun whole genome sequence was performed. Results:EM showed the presence of ~400 nm giant viruses, mimivirus-like, specifically labelled by anti-FeLV gag p27 Ab. The giant viruses had the reverse transcribing property. Whole genome sequence showed the presence of transforming retroviral genes in the large viral genome confirming that the Retro-Giant viruses are a distinct branch, missing from the current classification of retroviruses. Conclusions:Although sharing some of the morphological features with Mimiviruses, this human giant virus differs substantially from environmental DNA-giant viruses isolated so far, in that it manifests a unique mammalian transforming retroviral core and T cell tropism. The virus should not be confused with a classic human retrovirus nor even a large human retrovirus, but an ancestral human giant virus, mimivirus-like, with a mammalian retroviral core. Certainly, the oncogenic potential of the viral particle and its T cell tropism is of concern and further studies are needed to clarify the role of this giant virus in human diseases and evolution of archetypal retroviruses.
Exploring the Value of Waiting During Labor
Authors: Hicklin Karen , Ivy Julie S. , Payton Fay Cobb , Viswanathan Meera , Myers Evan 
Published: September 2018

Of the nearly four million births that occur each year in the United States, almost one in three is a cesarean delivery. Despite the increasing C-section rate over the years, there is no evidence that the increase has caused a decrease in neonatal or maternal mortality or morbidity. Bayesian decision analysis is used to model the decision between classifying a patient as “failure-to-progress,” which is cause for a C-section, using current information (prior probability) or information gathered (posterior probability) as labor continues. The Bayesian decision models determine the conditions under which it is appropriate to gather additional information (i.e., take an observation) before deciding to end labor and perform a C-section based on the decision maker’s belief about successful labor. During an observation period, the decision maker learns more about the patient and her medical state and the likelihood of a successful vaginal delivery is updated. This study determines the conditional value of information (conditional on the decision maker’s prior belief) and determines the conditions under which information has positive value. This model can be used to facilitate shared decision making for labor and delivery through communicating beliefs, risk perceptions, and the associated actions. The online appendix is available at https://doi.org/10.1287/serv.2018.0205 .
Better pathways to success? – A study of foundation studies alumni
Authors: Teo Ian , Chang Shanton 
Published: September 2018

Abstract
Foundation studies (or pathways) programmes (FSPs) seek to prepare international students for their transition into university by providing bridging courses to meet their academic, sociocultural and personal needs. The growth of such programmes over the previous decade has boomed to over 1000 English-medium providers worldwide and has been valued at $1.4 billion with no indication of slowing down. While these programmes serve an instrumental purpose in terms of providing international students with a pathway into university, it has become clear that these students seek more than just a qualification by the end of their sojourn, and value also the quality of their broader relationships, preparation and participation at university. For more than 25 years, Trinity College Foundation Studies (TCFS) in Melbourne has served to prepare a wide-range of international students for their higher education (HE) studies. The present study will report on quantitative and qualitative data derived from TCFS alumni who were surveyed at the start of 2017. In particular, two branches of alumni-related expectations and experiences will be addressed. First, the types of extra-curricula activities respondents reflected upon as being important for their broader welfare or well-being while enrolled as foundation students will be discussed. Second, findings involving the types of support they sought during and after university, and the ways in which they wished to reconnect with TCFS will be described. Implications and recommendations relating to the aforementioned data will subsequently be presented.
Su P.Ibscher S.N. (= P.Berol. 18122) Note Di Lettura E Ipotesi Di Ricostruzione Dei Vv. 1–6
Authors: Cutuli Silvia 
Published: September 2018

Abstract
This article considers a new reading of the first lines in P.Ibscher s.n. (= P.Berol. 18122). Meleager and Theseus have a conversation in the underworld. The former hero asks the latter about his presence in the kingdom of death. The sequence of direct questions reflects the narrative modalities of meetings between heroes attested in Homeric epic.
Foreign official holdings of US treasuries, stock effect and the economy: a DSGE approach
Authors: Francois John Nana 
Published: September 2018

Abstract
This paper examines the effects of shocks to foreign official holdings of long-term U.S. Treasuries (FOHL) on macroeconomic aggregates using a dynamic general equilibrium model. The model treats short- and long-term bonds as imperfect substitutes through endogenous portfolio adjustment frictions. This provides a channel for changes in relative supply of assests to influence asset prices. Three key findings emerge: (1) positive shocks to FOHL impact the long-term interest rate and the term spread negatively through a stock effect channel – defined as persistent changes in interest rates as a result of movement along the Treasury demand curve. This result is consistent with findings in the empirical literature. (2) Through a feedback mechanism from an endogenous term structure in the model, the decline in the long-term interest rate induces an expansion in economic activity which leads to an increase in consumption, output and inflation. Both the stock effect and the feedback mechanism are generated by the portfolio frictions. (3) Higher degrees of persistence of FOHL shocks or imperfect asset substitution generate a prolonged negative stock effect following shocks to FOHL. This causes a longer delay of the term spread to return to its steady state after it falls; hence, inducing an extended and stronger stimulative feedback effect from the endogenous term structure into the modeled economy. These findings help explain macroeconomic events such as the so-called ``Greenspan conundrum'' of the mid 2000s.
A Unified Algorithm for Solving Split Generalized Mixed Equilibrium Problem, and for Finding Fixed Point of Nonspreading Mapping in Hilbert Spaces
Authors: Jolaoso Lateef Olakunle , Oyewole Kazeem Olawale , Okeke Chibueze Christian , Mewomo Oluwatosin Temitope 
Published: September 2018

Abstract
The purpose of this paper is to study a split generalized mixed equilibrium problem and a fixed point problem for nonspreading mappings in real Hilbert spaces.We introduce a new iterative algorithm and prove its strong convergence for approximating a common solution of a split generalized mixed equilibrium problem and a fixed point problem for nonspreading mappings in real Hilbert spaces. Our algorithm is developed by combining a modified accelerated Mann algorithm and a viscosity approximation method to obtain a new faster iterative algorithm for finding a common solution of these problems in real Hilbert spaces. Also, our algorithm does not require any prior knowledge of the bounded linear operator norm. We further give a numerical example to show the efficiency and consistency of our algorithm. Our result improves and compliments many recent results previously obtained in this direction in the literature.
Novel PWM Control with Modified PSO-MPPT Algorithm for Reduced Switch MLI Based Standalone PV System
Authors: Panda Kaibalya Prasad , Anand Abhisekh , Bana Prabhat Ranjan , Panda Gayadhar 
Published: September 2018

AbstractThis paper proposes a new version of swam optimization based algorithm for maximum power harvesting from the multilevel inverter (MLI) based photovoltaic (PV) generation systems. The ability of modified particle swarm optimization (MPSO) based maximum power point tracking (MPPT) approach is investigated for varying environmental conditions and partial shading condition. Moreover, the tracking performance is compared with perturb and observe (P&O) MPPT and standard PSO-MPPT techniques. MLIs are chosen over conventional two-level inverters due to many advantages such as; power quality improvement in PV generation system, reduce the filter size requirement etc. With the increase in number of levels; the conventional MLI circuit leads to bulky & costly due to the requirement of more number of power electronics switches. Therefore, in this work a novel MLI with reduced number of switches has been developed for off-grid PV system. Harmonic reduction is principally depended on the modulation strategy used to control the MLI. In this regard, a logical switching state selection PWM control technique is presented for the proposed MLI. The overall system is simulated in MATLAB/SIMULINK and new solution to attain MPPT from standalone PV generation system has also been validated experimentally in the laboratory.
Waveguide-integrated superconducting nanowire single-photon detectors
Authors: Ferrari Simone , Schuck Carsten , Pernice Wolfram 
Published: September 2018

Abstract
Integration of superconducting nanowire single-photon detectors with nanophotonic waveguides is a key technological step that enables a broad range of classical and quantum technologies on chip-scale platforms. The excellent detection efficiency, timing and noise performance of these detectors have sparked growing interest over the last decade and have found use in diverse applications. Almost 10 years after the first waveguide-coupled superconducting detectors were proposed, here, we review the performance metrics of these devices, compare both superconducting and dielectric waveguide material systems and present prominent emerging applications.
Investigation of Gamma-Ray’s Transmission Geometries for the Measurement of Attenuation Coefficients
Authors: Mann Kulwinder Singh , Mann Sukhmanjit Singh 
Published: September 2018

Abstract
For the measurement of attenuation parameters of any material for gamma (γ)-rays, the narrow-beam transmission geometry is one of the essential requirements. Linear attenuation coefficient (μ, cm−1), half value layer thickness and mean free path are some fundamental parameters used for the analysis of γ-ray attenuation behaviour of any material. The complete experimental setup used to measure these parameters is termed as γ-ray transmission geometry. The geometrical parameters such as the size of collimator aperture, thickness of sample (absorber), source to absorber (SA) distance, absorber to detector distance and source to detector distance (STD) are deciding factors for the nature of γ-ray transmission geometry. A novel geometrical parameter, scattered-to-transmission ratio (STR), has been proposed in this investigation. STR provides qualitative information of various geometrical parameters. It provides influence on the nature of transmission geometry for experimental measurements by various geometrical parameters and buildup factor. To investigate its influence, STR values have been analysed by varying sizes of collimator aperture between 3 and 12 mm and absorber thicknesses between 20 and 280 mm for fixed SA and STD. Six standard building materials (cement black, cement white, clay, red mud, lime stone and plaster of paris) have been used for the investigation. The point isotropic γ-ray sources Cs-137 (3700 M Bq) and Co-60 (370 M Bq) have been used in this study. It has been found that STR provides better information of scattered γ-rays by the material than its buildup factor (B). Additionally, CSTR (the critical value of STR) serves as an extensive parameter to distinguish between narrow-beam (good) and broad-beam (poor) γ-ray transmission geometries.
Oraciones factitivas sintéticas y tipos de instrumentos en español
Authors: Vera Luján Agustín 
Published: September 2018

Algunos estudios han destacado la existencia de verbos, a los que llaman factitivos, que se construyen con un agente meramente instigador de una acción que realiza otro agente diferente. En nuestro trabajo ponemos de manifiesto cómo semejante descripción del funcionamiento de estos verbos es inadecuada, pues postula la concurrencia de dos papeles temáticos del mismo tipo en un mismo esquema oracional simple. En nuestro trabajo se propone describir estas construcciones como esquemas oracionales de agente en los que concurre, además, un mecanismo de metaforización por el que un concepto meta instrumental se emplea para hacer referencia a un concepto destino agente. Para describir exhaustivamente el funcionamiento de estas construcciones, establecemos, además, cómo resulta necesario diferenciar, dentro del papel temático de instrumento, entre los que denominamos instrumentos intermediarios de control permanente y de control momentáneo.
POTENSI DARK TOURISM DALAM PENERAPAN DESTINATION PERSONALITY DI BANDUNG MEDICAL CENTER
Authors: Panigoro Aggi 
Published: September 2018

Keberagaman aktivitas yang dilakukan di objek dark tourism di Bandung Medical Center sangat beragam. Destination personality Bandung Medical Center sebagai dimensi dari Shopistication dilihat dari Priositas yang ditawarkan objek dark tourism di Bandung Medical Center kurang dilihat sisi keamanan dan tempat yang tidak memadai untuk level Shopistication. Daya tarik Bandung Medical Center sebagai destinasi wisata berpetualang ghost dan dark tourism.sangat menarik. Bandung Medical Center memliki potensi dark tourism merupakan daya tarik wisata bagi Bandung. Tetapi unsur dari dark tourismnya sedikit karena harus terdapat unsur sejarah, kematian, politik , pembantaian yang ditonjolkan dari Bandung Medical Center hanya unsur mistis dilihat dari spectrum dark tourism mulai dari kriteria tujuan sampai goal yang didapat dari dark tourism BMC.
Pengaruh Sistem Reward Dan Budaya Kerja Terhadap Kepuasan Kerja Dan Implikasinya Pada Kinerja Tenaga Kerja Indonesia Di Busan Korea Selatan
Authors: Muhammad Aziz 
Published: September 2018

Sumber daya manusia merupakan pelaksana kegiatan produksi dalam mencapai tujuan perusahaan ditentukan oleh kualitas sumber daya manusia yang berperan penting dalam kegiatan operasional perusahaan. Berdasarkan pencapaian kinerja yang diukur dari hasil per pekerja tenaga kerja Indonesia di Korea Selatan belum optimal. Penelitian ini bertujuan untuk mengetahui gambaran sistem reward, budaya kerja, kepuasan kerja dan kinerja pada tenaga kerja Indonesia di Busan Korea Selatan.Penelitian ini menggunakan metode descriptive explanatory survey. pengumpulan data dengan cara studi dokumentasi, dan penyebaran angket. Populasi penelitian ini adalah tenaga kerja Indonesia di Busan Korea Selatan yang berjumlah 2093 orang. Berdasarkan hasil perhitungan sampel dengan menggunakan rumus slovin diperoleh 336 orang yang terdistribusi secara proporsional. Untuk mengukur besarnya pengaruh sistem reward, budaya kerja dan kepuasan kerja terhadap kinerja, digunakan teknik analysis path (analisis jalur) dengan menggunakan software SPSS versi 23.Hasil penelitian menunjukan bahwa sistem reward efektif, budaya kerja kuat, tingkat kepuasan kerja tinggi, tingkat kinerja tinggi. Sistem reward dan budaya kerja memiliki pengaruh positif terhadap kepuasan kerja. Pengaruh sistem reward, budaya kerja, dan kepuasan kerja memiliki pengaruh positif terhadap kinerja.
Modeled and Measured Ecosystem Respiration in Maize–Soybean Systems Over 10 Years
Authors: Zhan Ming , Liska Adam J. , Nguy‐Robertson Anthony L. , Suyker Andrew E. , Pelton Matthew P. , Yang Haishun 
Published: September 2018

Core Ideas
The combination of crop and soil models can predict daily measured CO2 emissions.
Crop residue is the main source of carbon inputs to soil and largely determines soil organic carbon.
Where residue is removed for biofuels, increased carbon emissions will occur.
Crop residue is an abundant resource for the potential production of biofuels, but a better understanding of its use on net carbon emissions must be developed to mitigate climate change. This analysis combines two established crop growth models (Hybrid‐Maize and Soysim) with a simple soil and crop residue respiration model to estimate daily ecosystem respiration (ERe) from maize and soybean; ERe was estimated to be the sum of CO2 emissions from the oxidation of the growing crop, crop residue, and soil organic carbon (SOC). Model‐estimated CO2 fluxes from irrigated continuous maize and irrigated maize–soybean cropping systems in eastern Nebraska were compared with tower eddy covariance measurements of CO2 fluxes from 2001 to 2010 from those fields. Modeled C emissions closely estimated measured seasonal patterns of CO2 dynamics and measured daily ERe (R2: 0.87, 0.84). Measured and modeled annual ERe values were also compared and better agreement was found in maize compared to soybean. As there are limited comparisons of modeled soil emissions with eddy covariance measured CO2 fluxes, this study is important for the validation of these types of models and to support their potential use in quantifying emissions from crop residue for biofuels.