bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mobile learning in Romania, a failed experience?
Authors: Stan Emil 
Published: May 2019

Some specialists in education sciences doubt the presence of computer resources in formal education: an almost general feeling that they might represent the Trojan horse wheeling in superficiality, ignorance and lack of discipline (Alessandro Barricoâ€™s barbarians), destroying the â€˜seriousâ€™ vein of schools, but arenâ€™t there computers in schools? Isnâ€™t there an IT infrastructure widely used in education? When the administration takes over, they make a special room, and they put the computers in that room and they have a computer period with a computer teacher. Our study starts from the hypothesis that the usage of mobile learning in class will intensify learning; starting from this idea, we planned to analyse how much the teachers from a specific region of Romania have at their disposal, the resources and competencies needed for mobile learning and in what measure they are really using those resources and competencies in a systematic manner in the educational.
Keywords: Mobile learning, multitasking, net generation, school teaching
Being a mother of children with ADHD and the problems it causes to mothers
Authors: Ozdemir Nurgul , Abaci Erginyavuz Kubra 
Published: May 2019

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in the childhood period. In the children, the symptoms of this disorder are reluctance to tasks that require attention, disorganisation, losing things frequently, forgetting homework, restlessness, being unable to wait their turn and so on. Those children, who are hyperactive, impulsive and distracted, might experience severe problems in their relationship with their families, parents, peers and friends. Compared to the parents of normal children, the parents of children with ADHD, especially the mothers who play a more active role in child care, are more likely to suffer from stress, anxiety and depression in the course of time. Therefore, in order to protect family functionality and provide a healthy communication between the parents and the child, it is crucial to raise parentsâ€™, in particular mothersâ€™, awareness on ADHD and its treatment for the evaluation of parentsâ€™ psychological state and referring them to a specialist, if necessary.
Keywords: ADHD, child, mother, psychological problems, psychiatric nursing.
METHODS OF QUESTIONING IN ARABIC AND YORUBA: A COMPARATIVE STUDY/ أساليب الاستفهام في العربية ويوربا: دراسة تقابلية
Authors: Adebisi Aliy Abdulwahid , Akanni Abdullahi Shittu 
Published: May 2019

<p>Interrogative methods is a fundamental part of a language that is common in all human conversation and speeches in their corporate lives, comparative analysis between languages of the same origin and those of different sources have been carried out to fully identify the likely challenges that might be encountered by learners of linguistics and probable lasting solution to those problems, thus, the research aims to study the contrasting between the two languages with specific attempts at reviewing the interrogational methods and in a bid to draw on the differences. The methodology adopted is an analytical and contrastive method, and the major findings of the thesis include: (1) the interrogative methods in both languages are similar, and as such, the student will not encounter many challenges in the course of learning both languages. (2) There are significant differences in the use of the interrogational particles and adaptations in the studied languages. For instance, all of the interrogative elements of Arabic language are generally placed at the beginning of sentences while in the Yoruba language, it varies between the beginning and terminal positions; and (3) Arabic language possess the quality of being composed of the variable and fixed elements but the Yoruba language is mainly composed of fixed elements, and this can pose a big challenge to students.</p>The study concluded that there are no such gaps in interrogative methods of both languages, except in some cases of fixed and non-fixed elements in Arabic, the study therefore, recommended that curriculum designers should consider areas of similarities and dissimilarities while designing curriculum in order to have suitable curriculum for students of Arabic among the Yoruba and the necessity that teachers should familiarize themselves with linguistic contrasts; which would enable them to perform their professional assignment and task in the easiest and most efficient.
Identifying Opportunities and Challenges of Human Resources in Smart Development Projects in Egypt
Authors: Khodeir Laila M. , Nabawy Mohamed 
Published: May 2019

Design and building of Smart development projects (SDP) has arrived to be one of the most essential targets by most of the countries worldwide. This is due to the positive impact on the qualities of countries living standards, economic situation and human working force engagement. The Egyptian 2030 strategic plan (2016) aims at constructing SDP with identified specific vision and strategy in Egypt. Despite, the design and building of SDP in Egypt is expected to offer many (HR) opportunities, but also it shall generate different challenges which might lead to drastic failures. Technological solutions, among those challenges, must be understood as a tool to achieve goals and to tackle the challenges cities must face Helfert (2015). Skilled workforce is another major concern for development of SDP. According to Fails Management Institute’s (FMI) talent development survey (2015) 86% of respondents reported that their company was witnessing skilled labor shortages. Thus, the main aim of this paper is to identify human resource key Opportunities and Challenges arising from the internal and external stakeholder’s environments, where the paper assumes that such HR factors can impact the success of delivery of design and building of SDP. The paper undergoes a review for human resource challenges and opportunities in design and building of SDP. The factors were studied for case studies highlighted mainly from developed countries with an emphasis on the case of Egypt. A qualitative analysis was then performed to identify the key challenges impacting the success of building and designing new SDP. By the end of the paper a complete risk breakdown structure was obtained including key HR challenges and opportunities. The identified factors can then be successfully lamented into the development of Egyptian smart cities. The paper adds knowledge value in human resource project management concerned with building new smart projects.
Novel p53 delivery systems in the treatment of head and neck cancer
Authors: Lu Yingxin , Wang Hui 
Published: May 2019

Background:
Head and neck squamous cell carcinoma (HNSCC) is a severe cancer with high morbidity and mortality. Once diagnosed, more than 50% to 70% patients progress to advanced stages, resulting in poor prognosis after treatment. With the rapid development of technologies, especially the Next-Generation Sequencing, the critical role of tumor suppressor p53 in HNSCC patients has been further revealed.

Methods:
In this article, we hereby review the biological property of p53 in the control of cell repair by focusing on how p53 mutation and deletion lead to tumor cell growth and development. We also summarize the gene delivery systems and small molecules that have been used for p53 transfer in animal tumor models and clinical applications to assess transgene expression specificity and efficacy in the treatment of HNSCC.

Discussion:
Loss-of-Function of p53 is strongly associated with poor clinical response and outcome in HNSCC. Gain-of-function of p53 pathway may be an effective to cure HNSCC.

Conclusion:
Powerful delivery systems for reproduced p53 expression and activation in cancer cells would be a promising treatment to achieve therapeutic goal for HNSCC.
BNIP3-mediated Autophagy Induced Inflammatory Response and Inhibited VEGF Expression in Cultured Retinal Pigment Epithelium Cells Under Hypoxia
Authors: Chen Yuhong , Yan Quan , Xu Yihua , Ye Fuxiang , Sun Xiaodong , Zhu Hong , Wang Hong 
Published: May 2019

Background:
Bcl-2/adenovirus E1B-19kDa-interacting protein (BNIP3), an
important target of hypoxia-inducible factors-1 alpha (HIF-1α), was reported to be overexpressed
under hypoxic condition. Our previous study demonstrated the protective
effect on detached retina by BNIP3-mediated autophagy. The study investigated the role
of BNIP3-mediated autophagy in retinal pigment epithelial (RPE) cells under hypoxia,
and observed the relationship between BNIP3, vascular endothelial growth factor
(VEGF) and inflammatory response in hypoxic RPE cells.

Methods:
BNIP3 knock down in retinal pigment epithelial cells was performed by small
interfering RNA (siRNA) technology in ARPE-19 cells, a human RPE cell line. Both
control and BNIP3-knockdown ARPE-19 cells were then subjected to a hypoxic
challenge using cobalt (II) chloride (CoCl2). The expression of autophagy-related genes,
VEGF and inflammatory factors (IL-18, IL-8, MMP-2, MMP-9, NLRP3, TNF-α) in RPE
cells was examined using quantitative Polymerase Chain Reaction (qPCR). The protein
levels of HIF-1α, BNIP3, the maker proteins (ATG5, LC3,p62, Beclin-1) of autophagy
and the component proteins (p-p70S6K, p70S6K, mTOR, p-mTOR) of the mTORC1
pathway were analyzed by Western blot. BNIP3 subcellualr localization was detected by
immunofluorescence. Cell viability was measured with Cell Counting kit-8. Cell apoptosis
was examined by TUNEL staining and caspase-3 activity assay.

Results:
The expression levels of BNIP3, HIF-1α and marker genes of autophagy were
upregulated in ARPE-19 cells in response to hypoxia. Importantly, hypoxia-induced
autophagy was mediated by the mTORC1 pathway, and was blocked upon BNIP3
knockdown. Additionally, hypoxia reduced cell viability, which was relieved by an
mTORC1 inhibitor. Also, autophagy protected ARPE-19 cells from CoCl2-induced cell
apoptosis. Moreover, inhibition of autophagy upregulated the expression of VEGF and
IL-18, and downregulated the expression of other inflammatory factors in the hypoxic
ARPE-19 cells.

Conclusion:
BNIP3-mediated autophagy under hypoxia is involved in regulating
inflammatory response and VEGF expression, which consequently affects the cell
viability of RPE cells.
A Comprehensive Review on Preclinical Diabetic Models
Authors: Shakya Anshul , Chaudary Sushil Kumar , Garabadu Debapriya , Bhat Hans Raj , Kakoti Bibhuti Bhusan , Ghosh Surajit Kumar 
Published: May 2019

Background:
Preclinical experimental models historically play a critical role in the exploration
and characterization of disease pathophysiology. Further, these in-vivo and in-vitro preclinical experiments
help in target identification, evaluation of novel therapeutic agents and validation of treatments.

Introduction:
Diabetes mellitus (DM) is a multifaceted metabolic disorder of multidimensional aetiologies
with the cardinal feature of chronic hyperglycemia. To avoid or minimize late complications of
diabetes and related costs, primary prevention and early treatment are therefore necessary. Due to its
chronic manifestations, new treatment strategies need to be developed, because of the limited effectiveness
of the current therapies.

Methods:
The study included electronic databases such as Pubmed, Web of Science and Scopus. The
datasets were searched for entries of studies up to June, 2018.

Results:
A large number of in-vivo and in-vitro models have been presented for evaluating the mechanism
of anti-hyperglycaemic effect of drugs in hormone-, chemically-, pathogen-induced animal models
of diabetes mellitus. The advantages and limitations of each model have also been addressed in this
review.

Conclusion:
This review encompasses the wide pathophysiological and molecular mechanisms
associated with diabetes, particularly focusing on the challenges associated with the evaluation and
predictive validation of these models as ideal animal models for preclinical assessments and discovering
new drugs and therapeutic agents for translational application in humans. This review may further
contribute to discover a novel drug to treat diabetes more efficaciously with minimum or no side effects.
Furthermore, it also highlights ongoing research and considers the future perspectives in the field
of diabetes.
Desenvolvendo Indicadores de Produtividade e Qualidade em Hospitais: Uma Proposta de Método
Authors: Ramos Alberto Wunderler , Miyake Dario Ikuo 
Published: May 2019

Este artigo contempla a necessidade de tornar o processo de gestão mais integrado e efetivo na busca de melhores resultados em organizações da área da saúde, nas quais a prática da avaliação de desempenho ainda não está tão amplamente disseminada. Para isso, propõe um método para estabelecer indicadores de produtividade e qualidade em hospitais, com base em conceitos da gestão por processos e abordagem sistêmica. O método proposto foi aplicado em uma
pesquisa-ação realizada no contexto de um grande hospital que vem empreendendo esforços para se firmar como um centro de referência promovendo a melhoria de seus padrões de atendimento. O trabalho explicita como um sistema de indicadores de desempenho deve ser criado a partir da identificação dos processos-chave da organização. Ao final, fornece um exemplo de aplicação mostrando como o método
proposto estrutura a sequência dos passos requeridos para a definição, seleção e medição destes indicadores.
Prediabetes and Risk for Cardiac Death Among Patients With Coronary Artery Disease: The ARTEMIS Study
Authors: Kiviniemi Antti M. , Lepojärvi E. Samuli , Tulppo Mikko P. , Piira Olli-Pekka , Kenttä Tuomas V. , Perkiömäki Juha S. , Ukkola Olavi H. , Myerburg Robert J. , Junttila M. Juhani , Huikuri Heikki V. 
Published: May 2019

OBJECTIVE
To compare cardiac mortality in patients with CAD and prediabetes with that in CAD patients with normal glycemic status and type 2 diabetes.

RESEARCH DESIGN AND METHODS
The Innovation to Reduce Cardiovascular Complications of Diabetes at the Intersection (ARTEMIS) study included patients with CAD after revascularization (79%), optimal medical therapy, or both. Patients had type 2 diabetes (n = 834), impaired glucose tolerance (IGT; n = 314), impaired fasting glucose (IFG; n = 103), or normal glycemic status (n = 697) as defined on the basis of the results of an oral glucose tolerance test. The primary end point was cardiac death. Major adverse cardiac event (MACE: cardiac death, heart failure, or acute coronary syndrome) and all-cause mortality were secondary end points.

RESULTS
During a mean ± SD follow-up of 6.3 ± 1.6 years, 101 cardiac deaths, 385 MACEs, and 208 deaths occurred. Patients with IGT tended to have 49% lower adjusted risk for cardiac death (P = 0.069), 32% lower adjusted risk for all-cause mortality (P = 0.076), and 36% lower adjusted risk for MACE (P = 0.011) than patients with type 2 diabetes. The patients with IFG had 82% lower adjusted risk for all-cause mortality (P = 0.015) than the patients with type 2 diabetes, whereas risks for cardiac death and MACE did not differ significantly between the two groups. The adjusted risks for cardiac death, MACE, and all-cause mortality among patients with IGT and IFG did not significantly differ from those risks among patients with normal glycemic status.

CONCLUSIONS
Cardiac mortality or incidence of MACE in patients with CAD with prediabetes (i.e., IGT or IFG after revascularization, optimal medical therapy, or both) does not differ from those values in patients with normal glycemic status.
HAK KEPERDATAAN ANAK LUAR KAWIN DALAM PERSPEKTIF ILMU HUKUM BERPARADIGMA PANCASILA
Authors: Nurhayati B. Resti Nurhayati 
Published: May 2019

Anak adalah generasi penerus cita-cita bangsa. Di tangan merekalah kehidupan bangsa dan Negara kita titipkan. Namun dalam fakta sehari-hari, kehidupan seorang anak tidaklah selalu mudah, karena masyarakat bahkan hukum mendiskriminasikan anak berdasarkan ukuran yang dibuat oleh masyarakat maupun oleh hukum. Anak dibedakan menjadi anak sah dan anak luar kawin. Berdasarkan pembedaan tersebut, anak diperlakuan secara berbeda oleh masyarakat dan hukum. Tulisan ini bermaksud untuk menguraikan bahwa status hubungan hukum yang telah menyebabkan seorang anak dilahirkan ke dunia mestinya bukanlah satu-satunya ukuran untuk memberikan hak keperdataan bagi seorang anak. Metode yang digunakan adalah metode kualitatif, dengan menganalisis persoalan perlindungan anak luar kawin mendasarkan pada paradigma Pancasila. Berdasarkan analisa ditemukan bahwa setiap anak berhak atas perlindungan hukum yang layak untuk mendapatkan pemeliharaan dan pendidikan, berhak untuk tumbuh kembang sebagaimana mestinya, serta mendapatkan hak-hak lain yang perlu untuk mendukung perkembangan jiwa raganya. Kata kunci: Anak Luar Kawin, Hak Keperdataan Anak, Paradigma Pancasila.
HUKUM PERTAMBANGAN (KEPASTIAN HUKUM TERHADAP INVESTASI SEKTOR PERTAMBANGAN BATUBARA DI DAERAH)
Authors: Hartana Hartana 
Published: May 2019

Meskipun secara teoritis Indonesia menjadi negara yang potensial sebagai negara tujuan investasi, namun dalam praktik sering terjadi permasalahan yang menimbulkan ketidak pastian hukum. Misalnya kepastian hukum investasi bidang pertambangan. Fenomena ketidakpastian hukum tersebut seperti miss management pengelolaan wilayah pertambangan, tuntutan masyarakat terhadap ketidakadilan dalam pengelolaan pertambangan, penegakan hukum yang lemah dan tidak konsisten, serta berbagai permasalahan lain terkait dengan sistem hukum yang berlaku. Masalah kepastian hukum investasi di bidang pertambangan khususnya terhadap Izin Usaha Pertambangan batubara menurut penulis merupakan suatu persoalan yang menarik dan perlu dilakukan penelitian secara akademis. Dampak ketidakpastian hukum tersebut adalah menurunnya angka investasi pertambangan dalam negeri. Hal ini tampak dalam beberapa tahun terakhir tidak ada investasi asing berskala besar yang masuk ke Indonesia. Oleh karenanya pemerintah berupaya memperbaiki kondisi ini dengan menerbitkan Undang-undang baru yaitu Undang-Undang No. 4 Tahun 2009 tentang Pertambangan Mineral dan Batubara. Kata kunci : Hukum Pertambangan, Kepastian Hukum, Undang-Undang No. 4 Tahun 2009 tentang Pertambangan Mineral dan Batubara
AKIBAT HUKUM KEPAILITAN BADAN USAHA MILIK NEGARA PASCA BERLAKUNYA UNDANG-UNDANG NOMOR 17 TAHUN 2003 TENTANG KEUANGAN NEGARA
Authors: Edgar Tanaya Putu , Agus Sudiarawan Kadek 
Published: May 2019

BUMN merupakan badan hukum yang tunduk kepada prinsip-prinsip badan hukum. BUMN dalam menjalankan aktifitas bisnisnya dapat melakukan inefficiency yang menyebabkan ketidakmampuan BUMN untuk memenuhi kewajibannya (utang) kepada kreditor. Dalam hal BUMN memiliki utang kepada minimal 2 (dua) orang kreditor dan salah satunya telah jatuh tempo, maka BUMN dapat dimohonkan pailit oleh kreditor. BUMN yang dinyakan pailit oleh pengadilan niaga akan memberikan akibat hukum terhadap para pihak. Selain itu, kepailitan BUMN akan memberikan akibat hukum kepada negara pasca lahirnya Undang-Undang Nomor 17 Tahun 2003 tentang Keuangan negara. Pasca lahirnya Undang-Undang Nomor 17 Tahun 2003 tentang Keuangan negara, ketika utang debitor lebih besar dari jumlah aset BUMN maka negara secara tanggung renteng ikut serta bertanggung jawab membayar utang BUMN dengan menggunakan APBN. Hal ini sebagai akibat status kekayaan negara dan BUMN tidak terpisah. Kata Kunci: BUMN, Kepailitan, Harta Kekayaan Terpisah
PENERAPAN PIDANA PASAL 92 AYAT (1) HURUF A JO PASAL 17 AYAT (2) HURUF B UNDANG-UNDANG NOMOR 18 TAHUN 2013 TENTANG PENCEGAHAN DAN PENGRUSAKANHUTAN (ANALISIS PUTUSAN PENGANDILAN NEGERI SAROLANGUN NOMOR: 16/PID.SUS/2015/PN.SRL)
Authors: Lasmadi Sahuri , Sudarti Elly 
Published: May 2019

Penelitianini bertujuan: (1)Untuk menganalisis putusan hakim dalam menentukan unsur Pasal92 ayat (1) Huruf a Jo Pasal 17 ayat (2) huruf b Undang-Undang Nomor 18 Tahun 2013 untuk dapat diterapkan kepada pelaku Pengrusakan Hutan (Analisis Putusan pengadilan Negeri sarolangun Nomor: 16/PID.SUS/2015/PN.SRL); (2) Untuk menganalisis pertanggungjawaban pidana pelaku tindak pidana pengrusakan hutan sebagaimana diatur pada Pasal92 ayat (1) Huruf a Jo Pasal 17 ayat (2) huruf b Undang-Undang Nomor 18 Tahun 2013.Hasil penelitian:(1) Majelis Hakim untuk membuktikan unsur objektif dan unsur subjektif dari Pasal92 ayat (1) Huruf a Jo Pasal 17 ayat (2) huruf b Undang-Undang Nomor 18 Tahun 2013 berdasarkan fakta di persidangan dan fakta yuridis serta hal-hal yang memberatkan dan meringankan secara sosiologis dari terdakwa. Unsur objektif dan unsur subjektif diuraikan oleh Hakim secara detail dan atas pertimbangan tersebut Majelis Hakim yakin bahwa subyek hukum (terdakwa) bersalah, sehingga dijatuhkan pidana; (2) Penentuan pertanggungjawaban pidana terhadap pelaku tindak pidana pengrusakan hutan pada Pasal92 ayat (1) Huruf a Jo Pasal 17 ayat (2) huruf b Undang-Undang Nomor 18 Tahun 2013 pada Putusan Pengadilan Negeri Sarolangun Nomor: 16/PID.SUS/2015/PN.SRL yaitu dengan memperhatikan Actus Reus dan guilty mind atau mens rea,yaitu adanya hubungan batin dengan perbuatan dan menurut ukuran yang biasa dipakai masyarakat sebagai ukuran untuk menetapkan ada tidaknya hubunganbatin antara pelakudengan perbuatannyayang diatur dalam ketentuan pidana Pasal92 ayat (1) Huruf a Jo Pasal 17 ayat (2) huruf b Undang-Undang Nomor 18 Tahun 2013.
PROBLEMATIKA DALAM PELAKSANAAN DAN PENEGAKAN HUKUM PASAL-PASAL POLIGAMI DALAM MASYARAKAT ADAT BALI
Authors: Sudantra I Ketut 
Published: May 2019

Poligami adalah salah satu bentuk kekerasan terhadap perempuan. Secara yuridis, sudah ada peraturan yang mengatur prosedur poligami, yaitu Undang-undang Nomor 1 Tahun 1974 tentang Perkawinan beserta peraturan pelaksanaannya, yaitu Peraturan Pemerintah Nomor 9 Tahun 1975. Peraturan tersebut berlaku bagi seluruh warga negara Indonesia, termasuk masyarakat adat Bali (etnis Bali-Hindu). Pada prinsipnya, peraturan-peraturan tersebut membolehkan poligami tetapi dengan prosedur yang ketat sehingga dapat digunakan oleh seorang istri untuk mencegah suaminya berpoligami. Dalam kenyataannya, pelaksanaan dan penegakan peraturan-peraturan tersebut tidak efektif mencegah terjadinya kekerasan terhadap perempuan akibat dipoligami. Tulisan ini bertujuan mengungkapkan problematik-problematik yang terjadi dalam pelaksanaan dan penegakan ketentuan-ketentuan poligami bagi masyarakat adat di Bali. Metode yang digunakan untuk mengkaji permasalahan adalah metode penelitian kepustakaan yang dalam studi hukum disebut metode penelitian hukum normatif, dengan mengandalkan penggunaan data sekunder berupa bahan hukum (primer dan sekunder) dan bahan non-hukum. Hasil penelitian menunjukkan bahwa tidak efektifnya ketentuan-ketentuan poligami dalam Undang-undang Perkawinan dan peraturan pelaksanaannya untuk mencegah terjadinya poligami disebabkan masih adanya problematik pada sistem hukumnya, baik pada komponen substansi hukumnya, struktur hukumnya dan budaya hukumnya. Kata kunci: penegakan hukum, poligami, kekerasan terhadap perempuan.
A função revelante da arquitetura religiosa moderna em São Paulo: o concreto aparente dos templos religiosos e sua simbólica do Sagrado
Authors: Ribeiro Célia Maria , Xavier Donizete José 
Published: May 2019

O presente artigo tem por objetivo desenvolver, a partir da hermenêutica da arte de Paul Ricoeur, um diálogo fecundo com a arquitetura religiosa moderna questionando sobre a sua função revelante em relação ao Sagrado. O concreto aparente, chamado de arte brutalista, ganha aqui total significação. Aspectos poéticos e metafóricos constituem a sua simbólica, então, atestamos que o concreto aparente é, per se, um espaço poético-simbólico. Assim, ressalta-se que o equilíbrio sutil das virtualidades iconoclastas desses templos modernos e as ressurgências simbólicas do Sagrado seguem a orquestração da função revelante da arquitetura religiosa moderna em São Paulo.