bluuebunny/crossref_metadata_2025_split huggingface dataset:
A model for the reflection of terahertz signals from printed circuit board surfaces
Authors: Fricke Alexander , Achir Mounir , Le Bars Philippe , Kürner Thomas 
Published: March 2018

AbstractBased on vector network analyzer Measurements, a model for the specular reflection behavior of printed circuit boards in the Terahertz range has been derived. It has been calibrated to suit the behavior of the measurements using a simulated annealing algorithm. The model has been tailored for integration to ray-tracing-based propagation modeling.
Benzobicyclon Activity on Common Louisiana Rice Weeds
Authors: McKnight Benjamin M. , Webster Eric P. , Blouin David C. 
Published: March 2018

AbstractA study was conducted at three locations in Louisiana to evaluate the response of common Louisiana rice weed species to different rates of application of benzobicyclon herbicide. Benzobicyclon was applied at 31, 62, 123, 185, 246, 493, 739, 986, and 1,232 g ai ha–1into flooded field conditions when ducksalad was at the first elongated-leaf stage. Barnyardgrass, false pimpernel, and yellow nutsedge control never exceeded 50% from any rate of benzobicyclon applied, averaged across evaluation timing. Ducksalad control, averaged across evaluation timing, was 83% when treated with 493 g ha−1and did not increase when treated with higher rates of benzobicyclon. At 42 d after treatment (DAT), purple ammannia and Indian toothcup treated with 185 and 246 g ha–1of benzobicyclon were controlled 58% and 81%, respectively, and did not differ in control compared with higher rates of benzobicyclon. All weeds were hand-harvested from each plot and separated by species at the conclusion of the study. No differences in fresh-weight biomass were observed for barnyardgrass, false pimpernel, purple ammannia, or yellow nutsedge. Treatment with benzobicyclon at ≥62 g ha–1resulted in reduced ducksalad fresh weight 42 DAT compared with the nontreated sample. Indian toothcup fresh weight was reduced 77% to 96% compared with the nontreated sample when treated with benzobicyclon at 246 to 1,232 g ha–1.
Assessment of information resources for people with hypodontia
Authors: Barber Sophy , Pavitt Sue , Meads David , Khambay Balvinder , Bekker Hilary 
Published: March 2018

Abstract
Aim:
To assess the adequacy of patient information to support understanding and decision-making for people affected by hypodontia.

Methods:
1) Questionnaire to understand the provision of patient information by dentists; 2) Systematic search to identify online open-access patient information; 3) Quality assessment of written patient information.

Results:
Questionnaire response rate was 49% (319/649); 91% examined and/or treated people with hypodontia. Most general dentists referred patients to specialist services without providing written hypodontia information. The majority of dental specialists provide patient leaflets but less than a third used web-resources. Only 19% of respondents felt current resources were fit-for-purpose. Thirty-one patient resources (18 leaflets and 13 online) were assessed against quality criteria. The aim of the resource was seldom explicit, the content was often incomplete and variation in readability scores indicated high levels of literacy were required.

Discussion:
Access to, and quality of, patient information for hypodontia is inadequate. Current resources are not sufficiently comprehensive to prepare young patients to engage in shared dental care decisions with their parents and/or dental professionals.

Conclusion:
There is a need for improved access to, and provision of, information about hypodontia if dental professionals want to meet best practice guidance and involve patients in shared decision-making.
A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers
Authors: Thibaudeau Tiffany A. , Anderson Raymond T. , Smith David M. 
Published: March 2018

AbstractProtein accumulation and aggregation with a concomitant loss of proteostasis often contribute to neurodegenerative diseases, and the ubiquitin–proteasome system plays a major role in protein degradation and proteostasis. Here, we show that three different proteins from Alzheimer’s, Parkinson’s, and Huntington’s disease that misfold and oligomerize into a shared three-dimensional structure potently impair the proteasome. This study indicates that the shared conformation allows these oligomers to bind and inhibit the proteasome with low nanomolar affinity, impairing ubiquitin-dependent and ubiquitin-independent proteasome function in brain lysates. Detailed mechanistic analysis demonstrates that these oligomers inhibit the 20S proteasome through allosteric impairment of the substrate gate in the 20S core particle, preventing the 19S regulatory particle from injecting substrates into the degradation chamber. These results provide a novel molecular model for oligomer-driven impairment of proteasome function that is relevant to a variety of neurodegenerative diseases, irrespective of the specific misfolded protein that is involved.
Efficacy and safety of apatinib in patients with previously treated metastatic colorectal cancer: a real-world retrospective study
Authors: Gou Miaomiao , Si Haiyan , Zhang Yong , Qian Niansong , Wang Zhikuan , Shi Weiwei , Dai Guanghai 
Published: March 2018

AbstractNo definitive treatment strategy has been established for patients with metastatic colorectal cancer (mCRC) who experienced progression after three or more lines of chemotherapy. A total of 36 mCRC patients were enrolled in this retrospective study who received apatinib therapy under non-clinical trial setting after progression in People’s liberation army general Hospital from March 2015 and August 2017. Progression free survival (PFS), overall survival (OS), disease control rate (DCR), objective response rate (ORR) and treatment-related adverse events (AEs) were reviewed and evaluated. Five patients achieved partial response (PR), and 25 achieved stable disease (SD), and 6 achieved progression disease (PD), illustrating a DCR of 83.3% and an ORR of 13.9%. Median PFS was 3.82 m and median OS was not reached. The toxicities associated with apatinib were generally acceptable with a total grade 3/4 adverse event incidence of 27.8%. The most common grade 3/4 adverse events were hypertension (n = 4, 11.1%), liver function damage (n = 3, 8.3%) and hand–foot syndrome (n = 2, 5.6%). No drug-related death occurred. Apatinib therapy provides a reasonable option with an acceptable safety profile for Chinese mCRC patients failed to prior chemotherapy.
Sperm activation through orbital and self-axis revolutions using an artificial cilia embedded serpentine microfluidic platform
Authors: Panigrahi Bivas , Lu Chang-Hung , Ghayal Neha , Chen Chia-Yuan 
Published: March 2018

AbstractThe zebrafish sperm activation profoundly depends upon the homogeneous mixing of the sperm cells with its diluent in a quick succession as it alters the cell’s extracellular medium and initiates their motility. Manual stirring, the traditional method for zebrafish sperm activation is tedious, time-consuming, and has a poor outcome. In this aspect, an artificial cilia embedded serpentine microfluidic is designed through which hydrodynamic factors of the microfluidic environment can be precisely regulated to harness uniform mixing, hence ensuring a superior sperm activation. To quantify the sperm motility, computer assisted sperm analysis software (CASA) was used whereas to quantify the generated flow field, micro particle image velocimetry (μPIV) was used. With this proposed microfluidic, 74.4% of the zebrafish sperm were activated which is 20% higher than its currently existing manual measurements. The μPIV analysis demonstrates that the curvature of the microchannel induces an orbital rotation to the flow field along the length of the microchannel together with the artificial cilia actuation which instigates a local rotation to the flow field of the artificial cilia location. The collective rotation in the whole flow field induce vorticity that promotes the change in temporal dynamics of the sperm cells towards their activation.
Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model
Authors: Galli Andrea , Mens Helene , Gottwein Judith M. , Gerstoft Jan , Bukh Jens 
Published: March 2018

AbstractRibavirin (RBV) is a broad-spectrum antiviral active against a wide range of RNA viruses. Despite having been used for decades in the treatment of chronic hepatitis C virus (HCV) infection, the precise mechanism of action of RBV is unknown. In other viruses, it inhibits propagation by increasing the rate of G-to-A and C-to-U transitions. Here, we utilized the J6/JFH1 HCV cell-culture system to investigate whether RBV inhibits HCV through the same mechanism. Infected Huh7.5 cells were treated with increasing concentrations of RBV or its phosphorylated forms. A fragment of the HCV NS5B-polymerase gene was amplified, cloned, and sequenced to estimate genetic distances. We confirm that the antiviral effect of all three RBV-drug forms on HCV relies on induction of specific transitions (G-to-A and C-to-U). These mutations lead to generation of non-infectious virions, reflected by decreased spread of HCV in cell culture despite relatively limited effect on virus genome titers. Moreover, treatment experiments conducted on a novel Huh7.5 cell line stably overexpressing adenosine kinase, a key enzyme for RBV activation, yielded comparable results. This study indicates that RBV action on HCV in hepatoma cell-culture is exerted through increase in mutagenesis, mediated by RBV triphosphate, and leading to production of non-infectious viruses.
Long-term effects of mild traumatic brain injuries to oculomotor tracking performances and reaction times to simple environmental stimuli
Authors: Danna-Dos-Santos Alessander , Mohapatra Sambit , Santos Maria , Degani Adriana M. 
Published: March 2018

AbstractUnderstanding the long-term effects of concussive events remains a challenge for the development of modern medical practices and the prevention of recurrent traumas. In this study, we utilized indices of oculomotor performance and the ability to react to simple environmental stimuli to assess the long-term motor effects of traumatic brain injury in its mildest form (mTBI). We performed analysis of eye movement accuracy, investigated the presence of abnormal eye movements, and quantified time to react to simple environmental stimuli on long-term mTBI survivors. Results indicated the presence of impairments to basic neural functions used to explore and respond to environmental demands long after the occurrence of mTBIs. Specifically, the result revealed the presence of abnormal saccadic eye movements while performing horizontal smooth pursuit, diminished accuracy of primary saccadic horizontal eye movement, and a widespread slower reaction to both visual and auditory stimuli. The methodology used in this study indicated to be potentially useful in aiding future investigations of neural circuitry impaired by mTBI and provide indices of recovery in future clinical trials testing mTBI-related clinical interventions.
Nd3+-doped transparent tellurite ceramics bulk lasers
Authors: Dolhen Morgane , Tanaka Masayuki , Couderc Vincent , Chenu Sébastien , Delaizir Gaëlle , Hayakawa Tomokatsu , Cornette Julie , Brisset François , Colas Maggy , Thomas Philippe , Duclère Jean-René 
Published: March 2018

AbstractWe report on the laser emission of the polycrystalline ceramic obtained from the full and congruent crystallization of the parent glass 1Nd3+:75TeO2-12.5Bi2O3-12.5Nb2O5 composition. In particular, the current work underlines the importance of carefully controlling the heat treatment in order to solely crystallize the Bi0.8Nb0.8Te2.4O8 cubic phase and consequently avoid the formation of the BiNbTe2O8 orthorhombic phase that would be detrimental for optical purpose. The structure, microstructure and photoluminescence properties of the resulting transparent tellurite ceramics are characterized. The continuous-wave and gain-switching laser performances reveal that the emission remains perfectly single transversal mode in the range of pump powers explored. The maximum output power achieved was ~28.5 mW, for a pump power threshold of ~67 mW, and with associated efficiency and slope efficiency of ~22.5% and ~50%, respectively. These data definitely stand among the best results obtained so far for bulk laser tellurite materials and thus demonstrate the potential of such polycrystalline transparent ceramics as optically active materials. Finally, the laser emission characteristics in pulsed regime, at low and high repetition rates, are also provided: more than 6.5 W of peak power at a repetition rate of 728 kHz can be obtained.
Engineering antimicrobial coating of archaeal poly-γ-glutamate-based materials using non-covalent crosslinkages
Authors: Ashiuchi Makoto , Hakumai Yuichi , Nakayama Sawami , Higashiuchi Haruna , Shimada Kosuke 
Published: March 2018

AbstractWe are now entering a new age of intelligent material development using fine, sustainable polymers from extremophiles. Herein we present an innovative (but simple) means of transforming archaeal poly-γ-glutamate (PGA) into extremely durable polyionic complexes with potent antimicrobial performance. This new supra-polymer material (called PGA/DEQ) was subjected to nuclear magnetic resonance and X-ray diffraction spectroscopies to characterize in structural chemistry. Calorimetric measurements revealed its peculiar thermal properties; to the best of our knowledge, it is one of the most heat-resistant biopolymer-based polyionic complexes developed to date. PGA/DEQ is particularly useful in applications where surface functionalization is important, e.g., antimicrobial coatings. The spontaneously assembled PGA/DEQ coatings (without any additional treatments) were remarkably resistant to certain organic solvents (including chloroform), even at high salt concentrations (theoretically greater than those found in sea water), and various pH values. However, the pH-response tests also implied that the PGA/DEQ coatings could be removed only when concentrated citrate di-salts were used, whereas most crosslinked polymer composites (e.g., thermoset matrices) are difficult to recycle and treat downstream. We also discuss PGA/DEQ-immobilized surfaces that exhibit enigmatic microbicidal mechanisms.
Intraword Variability in Children With Cochlear Implants: The Long-Term Development up to 5 Years of Age and a Comparison With Children With Normal Hearing
Authors: Faes Jolien , Gillis Steven 
Published: March 2018

Purpose
This study evaluates intraword or token-to-token variability in the spontaneous speech of Dutch-speaking children with cochlear implants (CIs) longitudinally up to 5 years of age in comparison with intraword variability in age-matched peers with normal hearing (NH).

Method
Spontaneous speech samples of 9 children with CI were collected longitudinally up to age 5. The data of the NH control group consisted of cross-sectional recordings. Children's word productions were categorized into 4 response types of the variability score (consistent correct, consistent incorrect, variable with hits, variable with no hits), and the proportion of whole-word variation (PWV) was calculated.

Results
PWV was high in both groups of children but decreased with age. All response types of the variability score appeared in both groups. Children with CI were significantly more variable than their peers with NH up to age 4, but this difference has disappeared by age 5. Longer words had a higher PWV and were more often consistent incorrect and variable.

Conclusions
Intraword variability was characteristic of children with CI's spontaneous speech productions as it was in children with NH, and a similar factor (word length) affected variability in production. Group comparisons showed higher rates of intraword variability in children with CI, but they seemed to catch up with their peers with NH by age 5.
Laboratory verification of Fast & Furious phase diversity: Towards controlling the low wind effect in the SPHERE instrument
Authors: Wilby M. J. , Keller C. U. , Sauvage J.-F. , Dohlen K. , Fusco T. , Mouillet D. , Beuzit J.-L. 
Published: March 2018

Context. The low wind effect (LWE) refers to a characteristic set of quasi-static wavefront aberrations seen consistently by the SPHERE instrument when dome-level wind speeds drop below 3 ms−1. The LWE produces bright low-order speckles in the stellar point-spread function (PSF), which severely limit the contrast performance of SPHERE under otherwise optimal observing conditions.
Aims. In this paper we propose the Fast & Furious (F&F) phase diversity algorithm as a viable software-only solution for real-time LWE compensation, which would utilise image sequences from the SPHERE differential tip-tilt sensor (DTTS) and apply corrections via reference slope offsets on the AO system’s Shack-Hartmann wavefront sensor.
Methods. We evaluated the closed-loop performance of F&F on the MITHIC high-contrast test-bench, under conditions emulating LWE-affected DTTS images. These results were contrasted with predictive simulations for a variety of convergence tests, in order to assess the expected performance of an on-sky implementation of F&F in SPHERE.
Results. The algorithm was found to be capable of returning LWE-affected images to Strehl ratios of greater than 90% within five iterations, for all appropriate laboratory test cases. These results are highly representative of predictive simulations, and demonstrate stability of the algorithm against a wide range of factors including low image signal-to-noise ratio (S/N), small image field of view, and amplitude errors. It was also found in simulation that closed-loop stability can be preserved down to image S/N as low as five while still improving overall wavefront quality, allowing for reliable operation even on faint targets.
Conclusions. The Fast & Furious algorithm is an extremely promising solution for real-time compensation of the LWE, which can operate simultaneously with science observations and may be implemented in SPHERE without requiring additional hardware. The robustness and relatively large effective dynamic range of F&F also make it suitable for general wavefront optimisation applications, including the co-phasing of segmented ELT-class telescopes.
Rapidly Expanding Lateral Ventricular Meningioma Presenting with Intraventricular Hemorrhage following Remote Whole Brain Radiation and Stereotactic Radiosurgery
Authors: Prickett Joshua , Klein Brendan , Busch Christopher , Cuoco Joshua , Apfel Lisa , Marvin Eric 
Published: March 2018

AbstractIntraventricular meningiomas are uncommon intracranial tumors and infrequently present with hemorrhage. With only 10 reported cases in the literature, it is exceedingly rare for meningiomas of the ventricular system to present with hemorrhage. To our knowledge, this is the first report of a patient presenting with an acute intraventricular hemorrhage in relation to a ventricular meningioma suspected to be radiation induced. In addition, we review the current literature on hemorrhagic intraventricular meningiomas and review the natural history of radiation-induced meningiomas.
Training Addiction Counselors to Deliver a Brief Psychoeducational Intervention for Chronic Pain among Patients in Opioid Agonist Treatment: A Pilot Investigation
Authors: Butner Jenna L. , Bone Curtis , Ponce Martinez Caridad C. , Kwon Grace , Beitel Mark , Madden Lynn M. , Bono Madeline H. , Eller Anthony , Barry Declan T. 
Published: March 2018

Background Despite high rates of chronic pain among their patients, opioid agonist treatment (OAT) counselors report an absence of training to manage chronic pain. Methods A multidisciplinary team developed a tailored training for counselors to screen and address chronic pain via a brief psychosocial intervention, and implemented it with 52 addiction counselors. Data on knowledge (9 true-false items) as well as attitudes, interest, and perceived ability (scored on 5-point Likert-type scales) were collected from counselors before (pre-test), after (post-test) training, and after 6 months (follow-up). Results Pre-test knowledge scores varied considerably. Compared to pre-test, mean counselor knowledge scores increased significantly post-training and at follow-up (p's.<05). The training was associated with increases in positive attitudes toward the role of counselors in managing chronic pain, interest in assessing chronic pain, and counselor ability to assess as well as suggest appropriate interventions for pain (all p's <.05). Perceived ability to assess chronic pain and suggest appropriate treatment interventions were higher at follow-up than at pre-test (p's <.05). Conclusions Findings related to the initial evaluation of this training were promising, and future research is warranted to further examine the efficacy of training drug counselors on psychosocial interventions to manage chronic pain among OAT patients.
SMMB: a stochastic Markov blanket framework strategy for epistasis detection in GWAS
Authors: Niel Clément , Sinoquet Christine , Dina Christian , Rocheleau Ghislain 
Published: March 2018

AbstractMotivationLarge scale genome-wide association studies (GWAS) are tools of choice for discovering associations between genotypes and phenotypes. To date, many studies rely on univariate statistical tests for association between the phenotype and each assayed single nucleotide polymorphism (SNP). However, interaction between SNPs, namely epistasis, must be considered when tackling the complexity of underlying biological mechanisms. Epistasis analysis at large scale entails a prohibitive computational burden when addressing the detection of more than two interacting SNPs. In this paper, we introduce a stochastic causal graph-based method, SMMB, to analyze epistatic patterns in GWAS data.ResultsWe present Stochastic Multiple Markov Blanket algorithm (SMMB), which combines both ensemble stochastic strategy inspired from random forests and Bayesian Markov blanket-based methods. We compared SMMB with three other recent algorithms using both simulated and real datasets. Our method outperforms the other compared methods for a majority of simulated cases of 2-way and 3-way epistasis patterns (especially in scenarii where minor allele frequencies of causal SNPs are low). Our approach performs similarly as two other compared methods for large real datasets, in terms of power, and runs faster.Availability and implementationParallel version available on https://ls2n.fr/listelogicielsequipe/DUKe/128/.Supplementary informationSupplementary data are available at Bioinformatics online.