bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid around the distal tibialis posterior tendon on ankle MRI: prevalence and clinical relevance
Authors: Lee Sangoh , Oliveira Ines , Li Yueyang , Welck Matthew , Saifuddin Asif 
Published: October 2019

Objective:
It has been stated that the distal 1–2 cm of the tibialis posterior tendon (TPT) does not have a tendon sheath but rather a paratenon, and that any fluid seen around this segment on ankle MRI is considered to represent paratendonitis. The prevalence and clinical significance of isolated TPT paratendonitis diagnosed on ankle MRI is unknown. This study aims to correlate the presence of isolated distal segment TPT paratendonitis on ankle MRI, with the presence or absence of medial midfoot pain.

Methods:
A retrospective database of 195 consecutive 3 T ankle MRI studies was assessed for the presence of isolated TPT paratendonitis. Relevant clinical notes were available in 159 of these cases, and were reviewed for the absence or presence of medial midfoot pain.

Results:
Of 133 patients with both ankle MRI studies and clinical notes available, 53 (33.3%) patients had isolated TPT paratendonitis based on MRI. Of these, 37 (69.8%) had reported no medial foot pain on review of clinical records, while medial foot pain was recorded in 16 cases (30.2%). The comparison of TPT paratendonitis with clinically evident medial midfoot pain showed no statistically significant association (p = 0.19).

Conclusion:
Fluid signal intensity around the distal 1–2 cm of the TPT is a relatively common finding on ankle MRI. Therefore, care should be taken when reporting ankle MRI studies not to overstate the relevance of this finding.

Advances in knowledge:
There was no statistically significant relationship between medial midfoot pain and the presence of isolated TPT paratendonitis.
The accuracy of panoramic radiography as a screening of bone mineral density in women: a systematic review
Authors: Kinalski Mateus Azevedo , Boscato Noeli , Damian Melissa Feres 
Published: October 2019

Objectives: A systematic review and meta-analysis of diagnostic test accuracy studies was conducted to assess if the radiomorphometric indexes observed in panoramic radiographies could estimate reduced bone mineral density (BMD) similarly to standard technique the bone densitometry (dual energy X-ray absorptiometry) in females older than 30 years. Methods: A systematic search in four databases was conducted until January 2019. Two evaluators performed data extraction and evaluation of risk of bias independently, and agreement was achieved by consensus. Data were synthesized on a subgroup meta-analysis with a random effect model and the hierarchical summary receiver-operating characteristic curve was used to calculate pooled estimates of studies. Results: Thirty three studies were included and 12 different radiomorphometric indexes identified, including Mandibular Cortical Index (MCI). The final number of cases pooled for the analysis was 5266 females.The MCI for BMD loss (osteopenia) presented values of sensitivity 0.81 [95% confidence interval (CI), 0.78–0.84] and specificity 0.48 (95% CI, 0.45–0.50), while for osteoporosis sensitivity 0.35 (95% CI, 0.30–0.40) and specificity 0.88 (95% CI, 0.86–0.90). The mandibular cortical width presented values of sensitivity 0.58 (95% CI, 0.40–0.73), specificity 0.73 (95% CI, 0.60–0.83) for osteopenia, while for osteoporosis sensitivity 0.57 (95% CI, 0.36–0.76) and specificity 0.83 (95% CI, 0.68–0.92). Due to the high sensitivity, MCI presented a potential value as a screening tool for initial BMD loss (osteopenia), once tests presenting high sensitivity are described as rarely missing subjects with the disease. To the other hand, MCI to osteoporosis and Mandibular Cortical Width for both conditions are not recommended because presented specificity higher than sensitivity. Conclusion: The MCI can be recommended as a feasible tool to screen initial BMD loss (osteopenia) in females above 30 years old using panoramic radiography exams.
Proteome turnover in the bloodstream and procyclic forms of Trypanosoma brucei measured by quantitative proteomics
Authors: Tinti Michele , Güther Maria Lucia S. , Crozier Thomas W. M. , Lamond Angus I. , Ferguson Michael A. J. 
Published: October 2019

Background: Cellular proteins vary significantly in both abundance and turnover rates. These parameters depend upon their rates of synthesis and degradation and it is useful to have access to data on protein turnover rates when, for example, designing genetic knock-down experiments or assessing the potential usefulness of covalent enzyme inhibitors. Little is known about the nature and regulation of protein turnover in Trypanosoma brucei, the etiological agent of human and animal African trypanosomiasis. Methods: To establish baseline data on T. brucei proteome turnover, a Stable Isotope Labelling with Amino acids in Cell culture (SILAC)-based mass spectrometry analysis was performed to reveal the synthesis and degradation profiles for thousands of proteins in the bloodstream and procyclic forms of this parasite. Results: This analysis revealed a slower average turnover rate of the procyclic form proteome relative to the bloodstream proteome. As expected, many of the proteins with the fastest turnover rates have functions in the cell cycle and in the regulation of cytokinesis in both bloodstream and procyclic forms. Moreover, the cellular localization of T. brucei proteins correlates with their turnover, with mitochondrial and glycosomal proteins exhibiting slower than average turnover rates. Conclusions: The intention of this study is to provide the trypanosome research community with a resource for protein turnover data for any protein or group of proteins. To this end, bioinformatic analyses of these data are made available via an open-access web resource with data visualization functions.
Preferências de atividade física em adultos brasileiros: resultados da Pesquisa Nacional de Saúde
Authors: Wendt Andrea , Carvalho Wellington Roberto Gomes de , Silva Inácio Crochemore Mohnsam , Mielke Grégore Iven 
Published: October 2019

O objetivo do estudo foi verificar a distribuição dos diferentes tipos de práticas entre os praticantes de atividade física de uma amostra de adultos de acordo com características sociodemográficas. Estudo transversal utilizando dados da Pesquisa Nacional de Saúde (PNS) de 2013, com adultos de 18 anos ou mais, praticantes de atividade física (n = 17.350). As variáveis independentes foram sexo, faixa etária, escolaridade e regiões geográficas. As variáveis dependentes foram os tipos de atividade física mais praticadas na população. Para apresentar as frequências de prática de prática segundo região, escolaridade e idade as atividades as atividades foram divididas em três grupos: caminhada, exercício e esportes. Os dados foram analisados no STATA 12.1. Nos homens, as atividades mais comuns foram futebol (39,1%), caminhada (22,9%) e musculação (15,3%). Nas mulheres, foram a caminhada (48,9%), ginástica (19,2%) e musculação (14,2%). Nos homens, a prática de caminhada foi maior nos mais velhos, sem instrução e da região Centro Oeste (p < 0,001). Quanto a prática de exercícios, nos homens, este hábito foi mais comum entre os mais jovens, com maior escolaridade, e da região Sudeste (p < 0,001). Em relação aos esportes, a prática foi mais comum nos mais jovens, nos com maior escolaridade e da região Norte (p < 0,001), tanto nos homens quanto nas mulheres. A prática esportiva foi menos frequente nas mulheres. Os tipos de atividade têm grande influência da idade, escolaridade dos indivíduos e região do país. Estes aspectos devem ser levados em conta do planejamento de intervenções.
Turismo e transporte
Authors: Sichel Ricardo Luiz 
Published: October 2019

O presente artigo aborda, a partir de uma pesquisa na imprensa e na doutrina, a importância da indústria do turismo, como fator de desenvolvimento, de inclusão social, onde a logística do transporte ocupa papel relevante. Nesse sentido decorre a importância do transporte ferroviário de passageiros, em especial quando observado o grau de precariedade do transporte rodoviário. O mesmo cita o processo de privatização ocorrido na Polônia e de que forma esse modal poderia dotar a sociedade de um meio de transporte seguro e eficiente.
Asymptomatic thyroiditis; a few typical cases and the prevalence of this disease
Authors: Tsuboi Kumiko , Matoba Hannah 
Published: October 2019

Although asymptomatic thyroiditis (АГ) is well known by the present time, the prevalence of this disease is still disputed. We evaluated the incidence of A T at Thyroidology Department of Omori Hospital. Asymptomatic thyroiditis was detected in 61 out of 1113 patients (5.5%) during the period of July 1993 to June 1996. On admission, high levels of free thyroxin in the blood (hyperthyroxinemia) were detected in 306 patients. Asymptomatic thyroiditis was the cause of this condition in 38 (12.4%) patients. By the moment of examination of patients with A T, thyrotoxicosis was revealed in 38 patients, euthyroid status in 17, and hypothyrosis in 6 patients. Patients with euor hypothyrosis had complaints and presented with clinical signs of thyrotoxicosis 1-2 months before examination. Antibodies to thyroperoxidase and/or thyroglobulin were detected in 51 out of 61 (84%) patients with A T. Sometimes A T is regarded as diffuse toxic goiter (DTG), but a patient with this condition can develop A T. We should always remember about the possibility of AT but not DTG even in cases with pronounced thyrotoxicosis or with a history of DTG. Regular check-ups of thyroid function will help diagnose the condition without resorting to 1221. If a patient has symptoms of thyrotoxicosis, e. g. palpitation, thyroid function should be examined.
Неге аге 4 typical cases with AT to illustrate this. Patient No. 1 is a classical case of Hashimoto’s thyroiditis. Previously she developed an euthyroid status, and later thyroid destruction and dysfunction (transitory thyrotoxicosis followed by hypothyrosis) developed spontaneously without pregnancies or deliveries. Patient No. 2 had transitory thyrotoxicosis which was not followed by hypothyrosis, but with a transitory slight increase in TTH. She might have had AT3years before. Patient No. 3 aged 63years complained of angina pectoris and arrhythmia; later she was prescribed substitute therapy with L thyroxin for pronounced hypothyrosis (TTH 90.9 microunits/ml). In patient No. 4 DTG was erroneously diagnosed and she was prescribed therapy for this condition. Thyroid dysfunction was transitory in all patients, and the function recovered later.
SB XX 15071 + P.Mich. III 146: The American Journey of a Parted “Table of Parts”
Authors: Azzarello Giuseppina 
Published: October 2019

Abstract
This paper examines SB XX 15071 and P.Mich. III 146, two papyri containing tables of divisions, which have been edited separately but turn out to belong to the same roll. The article offers a new edition of the rejoined pieces, a thorough discussion of various aspects related to the roll, such as provenance and chronology, handwriting, presence of variants of result, purpose of the tables.
“Who are the
Aṣḥāb al-Ukhdūd
? Q 85:4‒10 in Near Eastern Context.”
Authors: Silverstein Adam 
Published: October 2019

Abstract
This article seeks to contribute to our understanding of a short Qurʾānic passage, Q 85:4‒10, which concerns the fate of the enigmatic Aṣḥāb al-Ukhdūd. It is argued that the ‘eschatological’ and ‘historical’ readings of this passage, which have generally been taken to be mutually exclusive options for its interpretation, are both indispensable for a full contextualization of the verses in question. Furthermore, regarding the historical reading of the passage, it is argued that the verses refer to the events recorded in Daniel 3, rather than to the Martyrs of Najrān episode that most exegetes (and many modern scholars) opt for. Finally, a new etymology for the word Ukhdūd is proposed.
Crossing Borders: ʿĀʾisha al-Bāʿūniyya and Her Travels
Authors: Homerin Th. Emil 
Published: October 2019

Abstract
Arabic scholarship and literature flourished during the Mamlūk period, and scholars and students from across the Muslim world were drawn to Cairo and Damascus. This led to opportunities for travel, education, and employment, yet these opportunities were available almost exclusively to men. In Syria and Egypt, and most of the medieval world, women’s involvement in travel, education, and public life, was often restricted. However, there were exceptions, including the prolific writer and poet ʿĀʾisha al-Bāʿūniyya (d. 1517). As a woman, she crossed a number of social and cultural borders in order to enter into the domain of religious scholarship and literary production. Drawing from historical and biographical sources, and especially from ʿĀʾisha al-Bāʿūniyya’s writings, I examine her social and intellectual background, her travels and scholarly interactions in order to highlight some of the social trends and intellectual forces at work in the late Mamlūk period.
L’identité de Sidé. Entre vérité et réalisme politique: de la légende à l’histoire et à la langue
Authors: Brixhe Claude 
Published: October 2019

Abstract
Avec le cas de Sidé, on constate que l’identité affichée par une communauté est chose complexe et mouvante. La partie orientale de la Pamphylie, au-delà de l’Eurymedon, avait échappé à la colonisation grecque. Commencée à la fin du IIe millénaire et connaissant plusieurs vagues, celle-ci avait imposé, à l’ouest du fleuve, un grec mâtiné de la langue indigène postlouvite. A l’est, sur le territoire de Sidé celle-ci est restée langue légitime. Lorsqu’Aspendos, à l’ouest et Sidé à l’est émergent dans l’histoiré, une solide inimitié semble les opposer: Sidé affirme son anatolité et, à en croire les bribes historiographiques qui nous sont parvenues, en cas de conflit les deux cités ne sont jamais dans le même camp. A partir de l’époque classique sans doute, cette inimitié est stimulée par une rivalité économique. L’aversion des Sidètes pour leurs voisins hellènes ou hellénisés ne les empêche pas d’être très sensibles aux atouts économiques et culturels de ces derniers. Ils leur font de multiples emprunts. Celui qui illustre le mieux cette attitude qui mêle aversion et attraction est l’écriture dont ils dotent leur langue: leur alphabet, comme le grec, note les voyelles, mais pour les caractères ils imaginent le plus souvent des traces aussi différents que possible de ceux de leurs correspondants grecs. Cet anatolisme virulent ne faisait pas problème tant que la Pamphylie n’appartenait pas au monde grec. La situation changea avec la conquête macédonienne. C’est très probablement alors que surgit le récit qui faisait de Sidé une colonie de Kymé d’Eolide. Ce récit rattachait Side au moins partiellement au monde grec. Or rien, ni a Side ni a Kyme, ne le confirme: sans doute un des nombreux mythes qui apparurent, surtout a partir de l’époque hellénistique, pour installer une cite dans l’histoire grecque. Avec l’arrivee d’Alexandre (334 a. C.), le sidétique ne perdit pas immédiatement sa légitimité et il fut écrit jusqu’au tournant du IIIe au IIe siècle. Mais les bilingues qu’il nous a laissées et la forme sidétique des anthroponymes grecs montrent que les Sidètes s’emparèrent rapidement de la koiné grecque.
Crystal structure of hexakis(μ2-azido-κ2
N:N)-diazido-κ1
N-tetrakis(phenanthroline-κ2
N,N′)tetrazinc(II), C48H32N32Zn4
Authors: Feng Yu-Quan , Zhong Zhi-Guo , Yue Zi-Long 
Published: October 2019

Abstract
C48H32N32Zn4, triclinic, P1̄ (no. 2), a = 9.9928(14) Å, b = 10.1374(14) Å, c = 14.2362(19) Å, α = 71.710(2)°, β = 76.166(2)°, γ = 71.086(2)°, V = 1280.1(3) Å3, Z = 1, R
gt(F) = 0.0314, wR
ref(F
2) = 0.0795, T = 296(2) K.
Crystal structure of 2-((2-(3-hydroxy-7-methylene-2,3-dihydro-7H-furo[3,2-g]chromen-2-yl)propan-2-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol – a marmesin derivative, C20H24O10
Authors: Li Yu-Yan , Nie Xu-Liang , Fu Xiao-Xiang , Li Bao-Tong , Peng Wen-Wen 
Published: October 2019

Abstract
C20H24O10, orthorhombic, P212121 (no. 19), a = 6.3728(6) Å, b = 14.3835(14) Å, c = 20.453(2) Å, V = 1874.8(3) Å3, Z = 4, R
gt(F) = 0.0272, wR
ref(F
2) = 0.0558, T = 296(2) K.
Mining expression and prognosis of FOLR1 in ovarian cancer by using Oncomine and Kaplan-Meier plotter
Authors: Su Qingyuan , Lv Qingyuan , Wu Ruijin 
Published: October 2019

Abstract

Objective: To further explore folate receptor 1 (FOLR1) gene expression in ovarian cancer and its association with patients’ prognosis by deep mining the Oncomine and Kaplan-Meier plotter databases.

Methods:
FOLR1 mRNA expression data of ovarian cancer were retrieved from the Oncomine database and further analyzed by comparing tumor to healthy tissue. The prognostic value of FOLR1 in ovarian cancer was analyzed by Kaplan-Meier Plotter, an online survival analysis database.

Results A total of 439 studies were included in the Oncomine database in multiple types of cancers. Of the 439 studies, there were 54 with statistical differences for the expression of FOLR1, 19 with increased expression of FOLR1 and 35 with decreased expression comparing ovarian cancer to normal ovary tissue. After searching the Oncomine database, six datasets were discovered comparing the mRNA expression in ovarian tumor to healthy tissue. FOLR1 mRNA expression in ovarian tumor was significantly higher than that of normal ovarian tissue (all p<0.05). The Kaplan-Meier Plotter database analyzed the correlation between FOLR1 expression and ovarian cancer patient’s prognosis. A significant difference of progression-free survival between FOLR1 high and low expressing groups was found in ovarian cancer patients (HR=1.14, 95%CI: 1.00-1.29, p=0.043). However, the overall survival was not statistically different between high and low FOLR1 expressing patients (HR=0.95, 95%CI: 0.84-1.09, p=0.48).

Conclusion
FOLR1 mRNA was found to be highly expressed in ovarian tumor compared to normal ovarian tissue. Elevated FOLR1 mRNA expression was associated with the poor progression-free survival.
Activity of Insula to Basolateral Amygdala Projecting Neurons is Necessary and Sufficient for Taste Valence Representation
Authors: Kayyal Haneen , Yiannakas Adonis , Kolatt Chandran Sailendrakumar , Khamaisy Mohammad , Sharma Vijendra , Rosenblum Kobi 
Published: October 2019

Conditioned taste aversion (CTA) is an associative learning paradigm, wherein consumption of an appetitive tastant (e.g., saccharin) is paired to the administration of a malaise-inducing agent, such as intraperitoneal injection of LiCl. Aversive taste learning and retrieval require neuronal activity within the anterior insula (aIC) and the basolateral amygdala (BLA). Here, we labeled neurons of the aIC projecting to the BLA in adult male mice using a retro-AAV construct and assessed their necessity in aversive and appetitive taste learning. By restricting the expression of chemogenetic receptors in aIC-to-BLA neurons, we demonstrate that activity within the aIC-to-BLA projection is necessary for both aversive taste memory acquisition and retrieval, but not for its maintenance, nor its extinction. Moreover, inhibition of the projection did not affect incidental taste learning per se, but effectively suppressed aversive taste memory retrieval when applied either during or before the encoding of the unconditioned stimulus for CTA (i.e., malaise). Remarkably, activation of the projection after novel taste consumption, without experiencing any internal discomfort, was sufficient to form an artificial aversive taste memory, resulting in strong aversive behavior upon retrieval. Our results indicate that aIC-to-BLA projecting neurons are an essential component in the ability of the brain to associate taste sensory stimuli with body states of negative valence and guide the expression of valence-specific behavior upon taste memory retrieval.SIGNIFICANCE STATEMENTIn the present study we subjected mice to the conditioned taste aversion paradigm, where animals learn to associate novel taste with malaise (i.e., assign it negative valence). We show that activation of neurons in the anterior insular cortex (aIC) that project into the basolateral amygdala (BLA) in response to conditioned taste aversion is necessary to form a memory for a taste of negative valence. Moreover, artificial activation of this pathway (without any feeling of pain) after the sampling of a taste can also lead to such associative memory. Thus, activation of aIC-to-BLA projecting neurons is necessary and sufficient to form and retrieve aversive taste memory.
Impacts of a Specific Cyclooxygenase-2 Inhibitor on Pressure Overload–Induced Myocardial Hypertrophy in Rats
Authors: Xie Zhixiang , Wang Shuyin , Liang Zijing , Zeng Liangbo , Lai Rongde , Ye Zheng , Liao Pinhu 
Published: October 2019

Objective: The aim of this study was to observe the impacts of the specific cyclooxygenase-2 inhibitor celecoxib on cardiac structures, functions, and inflammatory factors during the process of pressure overload–induced myocardial hypertrophy.
Methods: Twenty-four male Sprague Dawley rats were randomly divided into 3 groups: the sham operation group, the surgery group, and the celecoxib group. The model was established according to the abdominal aortic coarctation method.
Results: At 16 weeks, rats in the celecoxib group were fed a celecoxib-mixed diet (10 mg/kg) for 8 consecutive weeks. At week 24 after model establishment, the cardiac structures and functions were observed; changes in the levels of tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, prostaglandin E2 (PGE2), C-reactive protein (CRP), and uric acid (UA) were detected; and the contents of Smad1/2/3 proteins (Smad1, Smad2, and Smad3) were determined. Left ventricular mass index, the heart weight/body weight ratio, and TNF-α, TGF-β, PGE2, CRP, and UA levels of the celecoxib group were all significantly decreased relative to those of the surgery group (P < .05); moreover, the cardiac functions were significantly improved compared to those of the surgery group (P < .05).
Conclusions: These results show that inflammatory factors are involved in the myocardial hypertrophy process and that celecoxib may reverse myocardial hypertrophy through a variety of pathways.
Alcuíno Três livros sobre a fé na santa e indivisível Trindade. Ao glorioso imperador Carlos Magno a Deus devoto
Authors: Nascimento Carlos Arthur R. 
Published: October 2019

LIVRO 1
Prefácio
Em nome da santa Trindade. Embora estejamos afastados da alegria da felicidade bem-aventurada na cegueira deste exílio, como pena justíssima pelo pecado original, não estamos de tal modo cortados e separados dela que mesmo, no que é mutável e temporal, não saibamos buscar ou desejar a eternidade, a verdade, a felicidade. O que se percebe pelo fato de que não temos vontade nem de morrer, nem de nos enganar, nem de estar na miséria. Donde, por este instinto natural, é comum aos homens querer ser felizes, · embora o desejo da felicidade se encontre de modo diverso no espírito de cada um. De fato, alguns julgam que ser feliz é apoderar- se do reino terreno; outros, ter riquezas em abundância; outros, ser elevado às honras; outros, porém, alegram-se por serem cobertos de louvores; outros, anseiam pelos prazeres carnais. Ora, a verdadeira felicidade não pode de modo nenhum ser encontrada na volubilidade desta vida. Acerca do que somos admoestados, pelo curso inteiro das Sagradas Escrituras, a que nos elevemos do que é terrestre para o celeste, onde está a verdadeira e eterna felicidade; a qual, é mais do que certo, que ninguém pode chegar, senão pela fé da paz católica, com a cooperação da caridade de Deus e do próximo.