bluuebunny/crossref_metadata_2025_split huggingface dataset:
The road to auxiliariness revisited
Authors: Rosemeyer Malte , Grossman Eitan 
Published: February 2018

AbstractAuxiliary verbs are known to grammaticalize from lexical verbs, but how do lexical verbs acquire verbal complements to begin with? This article provides an account of the semantic and pragmatic basis of grammaticalization of the Spanish anterior (‘perfect’) [acabar +de + infinitive] from a lexical source construction meaningfinish. Based on a description offinishin terms of its qualia structure, we argue that verbs meaningfinishare lexically unsaturated, with an event variable that must be assigned a value, whether implicitly by inference or explicitly by a verbal complement. We show on the basis of historical corpus data from the 13th–18th centuries that overt lexical verb complements are initially motivated by informativity: the infinitive is used to describe the event when the type of event is unexpected. However, this original constructional meaning is eventually lost due to the process ofovertification, which has not been discussed in the literature on language change. Writers started using the infinitive in contexts in which the finished event is not unexpected. The subsequent development of the temporal meaning is motivated by the failure of listeners to accommodate too-costly presuppositions in a particular syntactic context, leading to the reanalysis of the constructional meaning. Consequently, overtification was a necessary condition for the subsequent temporalization of the construction. These findings shed light on possible reasons for the grammaticalization of auxiliary verb constructions, at both early and later stages in their developmental histories.
From middle to passive
Authors: Ahn Mikyung , Yap Foong Ha 
Published: February 2018

AbstractThis paper examines the relationship between middle and passive voice constructions in Korean, in particular how they have come to share the same grammatical marker-eci. Based on diachronic data from the UNICONC (Korean historical) database, spanning Old, Middle and Modern Korean (15th to 20th century), our analysis reveals that-eciwas initially used as a middle voice marker for spontaneous and inchoative events, with change-of-state as their common feature, then extended to transitive contexts, giving rise to passive voice usage. More recently,-ecihas developed into a marker of facilitative middle constructions as well. These semantic extensions involve shifts in aspectual focus from change-of-state to resultative-state, and further to potential aspect and mood. This analysis contributes to our understanding of the diachrony of voice markers beyond the causative-to-passive pathway commonly seen in Northeast Asia to include the middle-to-passive pathway, with typological implications.
But spell checker always corrects witch words eye misspelled
Authors: Riano Adriana , Margolin Sara J. 
Published: February 2018

Abstract
The present study examined spell checker software for both spelling recognition and production among college students. Sixty-four participants identified and corrected spelling in a prewritten story and produced spelling by writing a story. Both were completed with or without spell checker access. Results demonstrated differences between the performance of good and poor spellers (as defined using a baseline spelling test). When compared to good spellers, poor spellers corrected a greater percentage of spelling errors with spell checker than without. Spell checker helped all participants produce fewer spelling errors, but not fewer homophone errors. Additionally, more often than good spellers, poor spellers reported placing less effort into spelling words correctly when using spell checker. These findings suggest that poor spellers may have a greater need for spell checker than good spellers, and may be at a greater risk for relying on the software as the only step in the proofreading process.
How executive control predicts early reading development
Authors: de Sande Eva van , Segers Eliane , Verhoeven Ludo 
Published: February 2018

Abstract
Attentional and action control are two levels of executive control that are essential to early reading development. Together these levels enable the construction and monitoring of cognitive representations and of efficient task-behavior, which are both necessary to benefit from reading instruction. The longitudinal and unique contributions of this internal and external level of executive control to early reading are still unclear. We therefore examined how these control capacities facilitate reading development from kindergarten to second-grade. Attentional and action control and multiple early reading skills were assessed at all three time points. Structural Equation Modeling showed a mediation effect for attentional control and an indirect effect for action control to subsequent reading skills via the contributions to the precursor of phonological awareness. From these results it can be concluded that both types uniquely allowed for the emergence of kindergarten preliteracy skills, which in turn provided children with a better starting point for reading development in first- and second-grade.
Web-Based Alcohol Intervention for Nightclub Patrons: Opposite Effects According to Baseline Alcohol use Disorder Classification
Authors: Sanchez Zila M. , Sanudo Adriana 
Published: February 2018

Background: This study aimed to test the effectiveness of a Web-based intervention in preventing alcohol abuse among nightclub patrons. Methods: A probabilistic sample of the patrons of 31 nightclubs in São Paulo, Brazil, was invited to participate in an online screening using the Alcohol Use Disorders Identification Test (AUDIT). A total of 1057 patrons met the inclusion criteria to participate in the randomized controlled trial, with data collection at 0, 3, 6, and 12 months. At baseline, participants were classified into 2 AUDIT score groups: a “high-risk” group (AUDIT ≥8; 44%) and a “low-risk” group (AUDIT <8; 56%). In both groups, the intervention subgroup was exposed once to a personalized normative feedback screen with information on the participant's alcohol consumption and its potential consequences. Results: After 12 months, no differences were found between the intervention and the control conditions in either risk group. In the “high-risk” group, there were significant reductions of both the AUDIT score and the prevalence of binge drinking (BD) over time in both the control and the intervention subgroups. In addition, an effect of the intervention was observed at 6 months, i.e., there was an estimated 13% reduction in the AUDIT score in favor of the intervention subgroup (odds ratio [OR] = 0.87; 95% confidence interval [CI]: 0.76, 1.00). In the “low-risk” group, both the control patrons and those receiving the intervention had increased AUDIT scores. Conclusion: The results suggest that the time effect of participating in the study may have had a beneficial outcome in reducing harmful drinking among patrons in the “high-risk” group. The intervention is not recommended to the “low-risk” group.
Preliminary Investigation of a Videogame Prototype for Cigarette and Marijuana Prevention in Adolescents
Authors: Duncan Lindsay R. , Hieftje Kimberly D. , Pendergrass Tyra M. , Sawyer Benjamin G. , Fiellin Lynn E. 
Published: February 2018

Background: Videogames are becoming increasingly popular to deliver health interventions; however, their role in the primary prevention of cigarette and marijuana use has not yet been evaluated. The purpose of this study was to conduct a preliminary test of the efficacy of a role-playing videogame prototype, smokeSCREEN, aimed at developing knowledge and behavioral skills associated with primary prevention of cigarette and marijuana use. The authors also explored participants’ gameplay experience. Methods: This study employed a 1-group pretest-posttest design with 25 adolescent boys and girls aged 11 to 14 years ( Mage = 11.56, SD = 0.77) who had never tried cigarettes or marijuana. Participants played four 1-hour gameplay sessions over a 2-week period. Assessments of knowledge, self-efficacy, attitudes, perceived norms, and intentions related to cigarette and marijuana prevention were collected at baseline and 2-week and 12-week follow-ups. Ratings of gameplay experience were collected after the 2 weeks of gameplay. One-way repeated-measures analyses of variance (ANOVAs) were conducted. Results: Findings are (1) improvements in knowledge for both cigarette (Wilks’ λ = 0.62, F(2, 23) = 7.21, P = .004) and marijuana (Wilks’ λ = 0.67, F(2, 23) = 5.75, P = .009) use from pre- to post-gameplay that were characterized by large effects; and (2) nonsignificant trends in the expected direction emerged for changes in self-efficacy and perceived norms related to both cigarettes and marijuana that were characterized by medium-large effects. Overall, the players provided positive reports of their experience with the smokeSCREEN videogame prototype. Conclusions: These findings provide preliminary evidence that a videogame has the potential to influence key cognitive and motivational variables and can be an engaging means to deliver a cigarette and marijuana prevention intervention.
The peel of Citrus kawachiensis (kawachi bankan) ameliorates microglial activation, tau hyper-phosphorylation, and suppression of neurogenesis in the hippocampus of senescence-accelerated mice
Authors: Okuyama Satoshi , Kotani Yoshimi , Yamamoto Kana , Sawamoto Atsushi , Sugawara Kuniaki , Sudo Masahiko , Ohkubo Yuu , Tamanaha Arisa , Nakajima Mitsunari , Furukawa Yoshiko 
Published: February 2018

Abstract
We previously reported that the dried peel powder of Citrus kawachiensis, one of the citrus products of Ehime, Japan, exerted anti-inflammatory effects in the brain of a lipopolysaccharide-injected systemic inflammation animal model. Inflammation is one of the main mechanisms underlying aging in the brain; therefore, we herein evaluated the anti-inflammatory and other effects of the dried peel powder of C. kawachiensis in the senescence-accelerated mouse-prone 8 (SAMP8) model. The C. kawachiensis treatment inhibited microglial activation in the hippocampus, the hyper-phosphorylation of tau at 231 of threonine in hippocampal neurons, and ameliorated the suppression of neurogenesis in the dentate gyrus of the hippocampus. These results suggest that the dried peel powder of C. kawachiensis exert anti-inflammatory and neuroprotective effects.
Voluntary Programs To Encourage Refuges for Pesticide Resistance Management: Lessons from a Quasi‐Experiment
Authors: Brown Zachary S. 
Published: February 2018

AbstractEconomists often treat pesticide resistance as a common‐pool resource problem. While pecuniary economic incentives are the standard prescription for open‐access market failures arising from such resources, non‐pecuniary behavioral approaches (e.g., “nudges”) are also effective in some cases. Yet non‐pecuniary instruments have not previously been evaluated for managing pesticide resistance. I empirically evaluate the performance of such an intervention to manage pest resistance to genetically engineered Bacillus thuringiensis (Bt) corn. The U.S. Environmental Protection Agency permits sale of Bt seed conditional on seed producers compelling customers to plant mandated levels of non‐Bt refuge to delay the evolution of Bt resistance. Because of compliance challenges, the Bt seed producer Monsanto piloted a social marketing program to promote refuge in 17 North Carolina counties in 2013–2014. Using 2013–2016 sales data, I use difference‐in‐differences, fractional regression, discrete changes‐in‐changes, and matched differences econometric models to identify the average treatment effect of the program on refuge planting. Results suggest that if it had covered all corn growers in North Carolina, the intervention would have led the average grower to plant between 2.6% (preferred estimate) and 5.8% more refuge in 2014 compared to the counterfactual. The program increased by at least 12% the average probability of planting any refuge in 2014. I find little evidence that effects of the program persisted in subsequent years after cessation, nor that the program increased compliance with mandated refuge thresholds. Informed by behavioral economics research on other environmental and resource policies, I discuss the implications of these findings for pesticide resistance management.
chromswitch: a flexible method to detect chromatin state switches
Authors: Jessa Selin , Kleinman Claudia L 
Published: February 2018

Abstract

Summary
Chromatin state plays a major role in controlling gene expression, and comparative analysis of ChIP-seq data is key to understanding epigenetic regulation. We present chromswitch, an R/Bioconductor package to integrate epigenomic data in a defined window of interest to detect an overall switch in chromatin state. Chromswitch accurately classifies a benchmarking dataset, and when applied genome-wide, the tool successfully detects chromatin changes that result in brain-specific expression.

Availability and implementation
Chromswitch is implemented as an R package available from Bioconductor at https://bioconductor.org/packages/chromswitch. All data and code for reproducing the analysis presented in this paper are available at https://doi.org/10.5281/zenodo.1101260.

Supplementary information
Supplementary data are available at Bioinformatics online.
Hierarchical analysis of RNA-seq reads improves the accuracy of allele-specific expression
Authors: Raghupathy Narayanan , Choi Kwangbom , Vincent Matthew J , Beane Glen L , Sheppard Keith S , Munger Steven C , Korstanje Ron , Pardo-Manual de Villena Fernando , Churchill Gary A 
Published: February 2018

Abstract

Motivation
Allele-specific expression (ASE) refers to the differential abundance of the allelic copies of a transcript. RNA sequencing (RNA-seq) can provide quantitative estimates of ASE for genes with transcribed polymorphisms. When short-read sequences are aligned to a diploid transcriptome, read-mapping ambiguities confound our ability to directly count reads. Multi-mapping reads aligning equally well to multiple genomic locations, isoforms or alleles can comprise the majority (&gt;85%) of reads. Discarding them can result in biases and substantial loss of information. Methods have been developed that use weighted allocation of read counts but these methods treat the different types of multi-reads equivalently. We propose a hierarchical approach to allocation of read counts that first resolves ambiguities among genes, then among isoforms, and lastly between alleles. We have implemented our model in EMASE software (Expectation-Maximization for Allele Specific Expression) to estimate total gene expression, isoform usage and ASE based on this hierarchical allocation.

Results
Methods that align RNA-seq reads to a diploid transcriptome incorporating known genetic variants improve estimates of ASE and total gene expression compared to methods that use reference genome alignments. Weighted allocation methods outperform methods that discard multi-reads. Hierarchical allocation of reads improves estimation of ASE even when data are simulated from a non-hierarchical model. Analysis of RNA-seq data from F1 hybrid mice using EMASE reveals widespread ASE associated with cis-acting polymorphisms and a small number of parent-of-origin effects.

Availability and implementation
EMASE software is available at https://github.com/churchill-lab/emase.

Supplementary information
Supplementary data are available at Bioinformatics online.
Epidemiology of malnutrition in different care settings
Authors: Correia Maria Isabel Toulson Davisson , de Vasconcelos Generoso Simone 
Published: February 2018

AbstractDetermining the epidemiology of malnutrition is of utmost importance, since it is one of the most prevalent conditions in the community, residential care, and hospital settings. Nutrient imbalance, such as decreased provision of calories, proteins, vitamins, minerals and trace elements, leads to a progressive deficiency status, while the excess is associated with overweight and obesity. Both are considered malnutrition. Furthermore, malnutrition is associated with increased risk of morbidity and mortality, length of hospital stay, hospital readmissions, cost and decreased quality of life. Therefore, a stable nutritional status should be targeted as an integral part of healthcare, and routine nutritional assessment should be carried out as a quality assurance practice. Despite this, healthcare providers, including physicians and medical administrators, often overlook nutritional aspects.
Large-scale CO J = 1–0 observations of the giant molecular cloud associated with the infrared ring N35 with the Nobeyama 45 m telescope
Authors: Torii Kazufumi , Fujita Shinji , Matsuo Mitsuhiro , Nishimura Atsushi , Kohno Mikito , Kuriki Mika , Tsuda Yuya , Minamidani Tetsuhiro , Umemoto Tomofumi , Kuno Nario , Hattori Yusuke , Yoshiike Satoshi , Ohama Akio , Tachihara Kengo , Shima Kazuhiro , Habe Asao , Fukui Yasuo 
Published: February 2018

Abstract
We report an observational study of the giant molecular cloud (GMC) associated with the Galactic infrared ring-like structure N35 and two nearby H ii regions G024.392+00.072 (H ii region A) and G024.510−00.060 (H ii region B), using the new CO J = 1–0 data obtained as a part of the FOREST Unbiased Galactic Plane Imaging survey with the Nobeyama 45 m telescope (FUGIN) project at a spatial resolution of 21″. Our CO data reveals that the GMC, with a total molecular mass of 2.1 × 106 M⊙, has two velocity components of over ∼10–15 km s−1. The majority of molecular gas in the GMC is included in the lower-velocity component (LVC) at ∼110–114 km s−1, while the higher-velocity components (HVCs) at ∼118–126 km s−1 consist of three smaller molecular clouds which are located near the three H ii regions. The LVC and HVCs show spatially complementary distributions along the line-of-sight, despite large velocity separations of ∼5–15 km s−1, and are connected in velocity by the CO emission with intermediate intensities. By comparing the observations with simulations, we discuss a scenario where collisions of the three HVCs with the LVC at velocities of ∼10–15 km s−1 can provide an interpretation of these two observational signatures. The intermediate-velocity features between the LVC and HVCs can be understood as broad bridge features, which indicate the turbulent motion of the gas at the collision interfaces, while the spatially complementary distributions represent the cavities created in the LVC by the HVCs through the collisions. Our model indicates that the three H ii regions were formed after the onset of the collisions, and it is therefore suggested that the high-mass star formation in the GMC was triggered by the collisions.
The Impact of Positive Agricultural Income Shocks on Rural Chinese Households
Authors: Leight Jessica 
Published: February 2018

Abstract
In the post-collectivization period, rural Chinese households were required to sell part of their grain output to the state at a below-market price; however, increases in this quota price beginning in 1993 generated substantial positive income shocks. These income shocks also varied cross-sectionally in accordance with crop composition given that quotas were systematically larger for rice-producing households, generating a quasi-random source of variation in the size of the shock driven by climatic variation in suitability for rice cultivation. Households induced to experience relatively larger income shocks show evidence of decreased agricultural investment, increased investment in non-agricultural businesses, and increased migration as households gain increased income, consistent with the hypothesis that credit constraints may have constrained some households from entering non-agricultural production ex ante. In addition, there is evidence that these households were concentrated among households who had not previously diversified out of agriculture.
The Impact of Recipient Site External Expansion in Fat Grafting Surgical Outcomes
Authors: Oranges Carlo M. , Striebel Julia , Tremp Mathias , Madduri Srinivas , Kalbermatten Daniel F. , Schaefer Dirk J. 
Published: February 2018

Background:
The fat grafting process includes the 4 phases of tissue harvesting, processing, recipient-site preparation, and reinjection. Among them, the preparation of the recipient site has never been exhaustively reviewed. We aim to provide a comprehensive overview of the methods to prepare the recipient site through external expansion with the resulting outcomes.

Methods:
PubMed/Medline database was searched for studies on fat grafting recipient site preparation by applying the following algorithm: ((fat grafting) OR (lipofilling) OR (lipograft) AND (recipient site)). A priori criteria were used to review the resulting articles and identify those dealing with external expansion.

Results:
Fourteen studies published from 2008 through 2016 met inclusion criteria (4 case reports, 6 retrospective, and 4 prospective studies), representing 1,274 treated patients. Two devices for preexpansion were used with different protocols: BRAVA system and Kiwi VAC-6000M with a PalmPump. The 13 studies that applied the BRAVA system reported large fat volume transplantation to the breast (average > 200 cc). The most common complications were localized edema (14.2%), temporary bruising, and superficial skin blisters (11.3%), while the most serious was pneumothorax (0.5%). The majority of the studies reported enhancement of fat graft survival, which ranged between 53% and 82% at 6 months to 1 year follow-up, and high satisfaction of patients and surgeon.

Conclusions:
External expansion and fat grafting is a promising technique for breast reconstruction and augmentation. However, due to the overall low level of evidence of the available studies, further research is needed to validate the procedure.
Group B Streptococcal Cellulitis and Necrotizing Fasciitis in Infants
Authors: Wojtera Monika , Cheng Horace , Fiorini Kyle , Coughlin Kevin , Barton Michelle , Strychowsky Julie E. 
Published: February 2018

Background:
There is no consensus regarding approaches to infantile group B streptococcal (GBS) head and neck cellulitis and necrotizing fasciitis. We present a case of GBS necrotizing cellulitis and summarize the literature regarding the presentation and management of infantile head and neck GBS cellulitis and necrotizing fasciitis.

Methods:
The literature was searched using PubMed, Web of Science, EMBASE and Medline (inception to April 2017) by 2 independent review authors. Inclusion criteria encompassed case reports or case series of infants less than 12 months of age with GBS cellulitis of the head and neck or with GBS necrotizing fasciitis without restriction to the head and neck. Data were extracted using tables developed a priori by 2 independent review authors, and discrepancies were resolved by consensus.

Results:
An infant presenting at 33 days of age with GBS facial necrotizing fasciitis was successfully treated conservatively with antibiotics. Our literature search identified 40 infants with GBS head and neck cellulitis. Late-onset (98%), male gender (65%) and prematurity (58%) predominated. Penicillin is the main therapy used (97%). The 12 identified cases of necrotizing fasciitis were associated with polymicrobial etiology (36%) and broad-spectrum antibiotic use. Seventy-five percent required debridement, including 4 of 5 (80%) cases involving the head and neck.

Conclusions:
Skin and soft tissue involvement is an uncommon manifestation of late-onset GBS infection which requires antibiotic therapy and possibly surgical debridement cases with necrotizing fasciitis.