bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active smoking, secondhand smoke exposure and serum cotinine levels among Cheyenne River Sioux communities in context of a Tribal Public Health Policy
Authors: O'Donald Elena R. , Miller Curtis P. , O'Leary Rae , Ong Jennifer , Pacheco Bernadette , Foos Kathryne , Enright Kendra , O'Leary Marcia , Nez Henderson Patricia , Lewis Johnnye , Erdei Esther , Henderson Jeffrey A. 
Published: August 2019

IntroductionAmerican Indians and Alaska Natives face disproportionately high rates of smoking and secondhand smoke (SHS) exposure. The Cheyenne River Sioux Tribe (CRST) is among the few Tribal Nations controlling commercial tobacco exposures in public and work places. We had an opportunity to explore effects of the new commercial tobacco-free policy (implemented in 2015) in an environmental health study (2014–2016) that collected information about commercial tobacco use and SHS prevalence and examined predictor variables of serum cotinine concentrations.MethodsSelf-reported survey data were used in quantile regression statistical modelling to explore changes in cotinine levels, based on smoking status, smokeless tobacco consumption and SHS exposure.ResultsFrom enrolled 225 adults, 51% (N=114) were current smokers. Among 88 non-tobacco users, 35 (40%) reported current SHS exposure. Significant differences in cotinine median concentrations were found among participants with and without current SHS exposure. Extremely high cotinine concentrations (~100 times larger than the median) were detected in some non-tobacco users. After implementing the new smoke-free air Tribal policy, cotinine decreased in participants with intermediate (3–15 ng/mL, non-tobacco users with SHS exposure) and high (>15 ng/mL, mainly tobacco users) cotinine levels showing association with an abatement of opportunities for SHS exposure. Significant predictors of cotinine levels were sampling year, current smoking and tobacco chewing. No gender differences were observed in cotinine.ConclusionsOur results show decrease in cotinine concentrations in CRST participants since implementation of their ‘Smoke-Free Clean Air Act’ in 2015.
EFFECTS OF Pd2+ CONCENTRATION ON THE STRUCTURAL PROPERTY OF NICKEL-PLATED PLANT FIBER NON-WOVEN SHEET
Authors: QIN GUANGCHAO , LIU YOUHAO , ZHANG YU , CHEN HAODONG , DING CAN , LIU JUNFEI , CHENG BIN , CHEN ZHENMING , HUANG JUNJUN 
Published: August 2019

In this work, a facile method combined with PdCl2 solution immersing and electroless deposition to fabricate nickel-plated plant fiber non-woven sheet is demonstrated. The effect of [Formula: see text] concentration on the structural property of plated sheet was investigated using X-ray photoelectron spectroscopy, X-ray diffraction and scanning electron microscopy. Results showed that increasing activated time and PdCl2 concentration would facilitate the enhancement of Pd-adsorbed amount on the substrate surface. It would facilitate the deposition of nickel atom, the reduction of the surface electrical resistivity and the crystallization of plated coating due to the high catalytic sites. In addition, the lowest PdCl2 effective concentration was reduced with the increased of activated time.
Cadalso de los Vidrios leucogranite ‘Blanco Cristal’: a widely used heritage stone from Spain
Authors: Freire-Lista David M. , Fort Rafael 
Published: August 2019

Abstract

Cadalso de los Vidrios leucogranite is extracted from the Sierra de Guadarrama (Spanish Central System) under the trade name ‘Blanco Cristal’. It is a fine- to medium-grained, hypidiomorphic and equigranular building stone that has been used in many heritage buildings, such as the Villena Palace (1534). The current annual production of Cadalso de los Vidrios leucogranite is approximately 8000 m
3
, of which 40% is exported around the world. It has been used in places such as the Vieux-Port in Marseille (France), Cork International Airport (Ireland) and the Puri EXIM Bank of Jakarta (Indonesia) among others. It is currently being used in the construction of the iconic tower of Jesus Christ of the Sagrada Familia Basilica, in Barcelona (Spain). Cadalso de los Vidrios leucogranite Blanco Cristal has excellent petrophysical properties, a uniform colour and good resistance to thermal shock and freezing temperatures. These qualities make Blanco Cristal an ideal material for monuments and buildings.
Nancy Grace Roman and the Dawn of Space Astronomy
Authors: Roman Nancy Grace 
Published: August 2019

Dear readers: We are sad to report that, soon after submitting her draft manuscript for this prefatory chapter, Nancy Grace Roman passed away on December 25, 2018. This final version of her memoir has been lightly edited but remains very true to the original. However, an Abstract was missing. Rather than trying to synthesize one in Nancy Grace's inimitable style, we take this opportunity to comment briefly on her life and its significance. Nancy Grace Roman was born in 1925 and came of age scientifically in the United States during the 1940s and 1950s. Together with the equally fascinating prefatory by Vera Rubin ( ARAA, Vol. 49), which we also recommend to you, these two memoirs give us intimate insight into the obstacles faced by women astronomers trying to rise in the field during those years. Roman's memoir is bitingly candid, recounting numerous snubs by teachers, insultingly small salaries, and attempts by her thesis advisor to simultaneously exploit her scientific findings and smother her role in them. Discouragement at every turn from doing forefront research is what drove Roman into government service, where she found a niche and blossomed as one of the visionary founders of the US civilian space program. We do not know what impact Roman might have had as a researcher with access to the world's largest telescopes, but we do know that her influence as an enabler of other people's science was vast. Her sobriquet as the “Mother of Hubble,” bestowed by admirer Ed Weiler, is well deserved. Nancy Grace granted an audio interview to Joss Bland-Hawthorn on August 4, 2018, just a few months before her passing. It captures her persona more vividly than mere words on paper, and we recommend the online recording to you at https://www.annualreviews.org/r/nancy-grace-roman-interview .
Liraglutide improves hepatic steatosis and metabolic dysfunctions in a 3-week dietary mouse model of nonalcoholic steatohepatitis
Authors: Duparc Thibaut , Briand François , Trenteseaux Charlotte , Merian Jules , Combes Guillaume , Najib Souad , Sulpice Thierry , Martinez Laurent O. 
Published: August 2019

Nonalcoholic steatohepatitis (NASH) is an emerging health problem worldwide. However, efficacious pharmacological treatment for NASH is lacking. A major issue for preclinical evaluation of potential therapeutics for NASH is the limited number of appropriate animal models, i.e., models that do not require long-term dietary intervention and adequately mimic disease progression in humans. The present study aimed to evaluate a 3-wk dietary mouse model of NASH and validate it by studying the effects of liraglutide, a compound in advanced clinical development for NASH. C57BL6/J mice were fed a diet high in fat (60%), cholesterol (1.25%), and cholic acid (0.5%), along with 2% hydroxypropyl-β-cyclodextrin in drinking water (HFCC-CDX diet). Histological and biological parameters were measured at 1 and 3 wk. After 1-wk diet induction, liraglutide was administrated daily for 2 wk and then NASH-associated phenotypic aspects were evaluated in comparison with control mice. Prior to treatment with liraglutide, mice fed the HFCC-CDX diet for 1 wk developed liver steatosis and had increased levels of oxidative-stress markers and hepatic and systemic inflammation. For mice not treated with liraglutide, these aspects were even more pronounced after 3 wk of the dietary period, with additional liver insulin resistance and fibrosis. Liraglutide treatment corrected the diet-induced alterations in glucose metabolism and significantly reduced hepatic steatosis and inflammation. This study provides a novel 3-wk dietary model of mice that rapidly develop NASH features, and this model will be suitable for evaluating the therapeutic efficacy of compounds in preclinical drug development for NASH.NEW & NOTEWORTHY We propose a diet high in fat (60%), cholesterol (1.25%), and cholic acid (0.5%) along with 2% hydroxypropyl-β-cyclodextrin in drinking water (HFCC-CDX diet) as a new dietary model of nonalcoholic steatohepatitis. We used the HFCC-CDX model to reproduce the main features of disease development in humans for the purpose of facilitating the rapid screening of drug candidates and prioritizing the more promising candidates for advanced preclinical assessment and subsequent clinical trials.
Posttraumatic stress disorder is associated with altered gut microbiota that modulates cognitive performance in veterans with cirrhosis
Authors: Bajaj Jasmohan S. , Sikaroodi Masoumeh , Fagan Andrew , Heuman Douglas , Gilles HoChong , Gavis Edith A. , Fuchs Michael , Gonzalez-Maeso Javier , Nizam Shahzor , Gillevet Patrick M. , Wade James B. 
Published: August 2019

Posttraumatic stress disorder (PTSD) is associated with cirrhosis in veterans, and therapeutic results are suboptimal. An altered gut-liver-brain axis exists in cirrhosis due to hepatic encephalopathy (HE), but the added impact of PTSD is unclear. The aim of this study was to define linkages between gut microbiota and cognition in cirrhosis with/without PTSD. Cirrhotic veterans (with/without prior HE) underwent cognitive testing [PHES, inhibitory control test (ICT), and block design test (BDT)], serum lipopolysaccharide-binding protein (LBP) and stool collection for 16S rRNA microbiota composition, and predicted function analysis (PiCRUST). PTSD was diagnosed using DSM-V criteria. Correlation networks between microbiota and cognition were created. Patients with/without PTSD and with/without HE were compared. Ninety-three combat-exposed male veterans [ (58 yr, MELD 11, 34% HE, 31% combat-PTSD (42 no-HE/PTSD, 19 PTSD-only, 22 HE-only, 10 PTSD+HE)] were included. PTSD patients had similar demographics, alcohol history, MELD, but worse ICT/BDT, and higher antidepressant use and LBP levels. Microbial diversity was lower in PTSD (2.1 ± 0.5 vs. 2.5 ± 0.5, P = 0.03) but unaffected by alcohol/antidepressant use. PTSD ( P = 0.02) and MELD ( P < 0.001) predicted diversity on regression. PTSD patients showed higher pathobionts ( Enterococcus and Escherichia/Shigella) and lower autochthonous genera belonging to Lachnospiraceaeae and Ruminococcaceae regardless of HE. Enterococcus was correlated with poor cognition, while the opposite was true for autochthonous taxa regardless of PTSD/HE. Escherichia/Shigella was only linked with poor cognition in PTSD patients. Gut-brain axis-associated microbiota functionality was altered in PTSD. In male cirrhotic veterans, combat-related PTSD is associated with cognitive impairment, lower microbial diversity, higher pathobionts, and lower autochthonous taxa composition and altered gut-brain axis functionality compared with non-PTSD combat-exposed patients. Cognition was differentially linked to gut microbiota, which could represent a new therapeutic target. NEW & NOTEWORTHY Posttraumatic stress disorder (PTSD) in veterans with cirrhosis was associated with poor cognitive performance. This was associated with lower gut microbial diversity in PTSD with higher pathobionts belonging to Enterococcus and Escherichia/Shigella and lower beneficial taxa belonging to Lachnospiraceaeae and Ruminococcaceae, with functional alterations despite accounting for prior hepatic encephalopathy, psychoactive drug use, or model for end-stage liver disease score. Given the suboptimal response to current therapies for PTSD, targeting the gut microbiota could benefit the altered gut-brain axis in these patients.
Changes in motoneuron excitability during voluntary muscle activity in humans with spinal cord injury
Authors: Vastano Roberta , Perez Monica A. 
Published: August 2019

The excitability of resting motoneurons increases following spinal cord injury (SCI). The extent to which motoneuron excitability changes during voluntary muscle activity in humans with SCI, however, remains poorly understood. To address this question, we measured F waves by using supramaximal electrical stimulation of the ulnar nerve at the wrist and cervicomedullary motor-evoked potentials (CMEPs) by using high-current electrical stimulation over the cervicomedullary junction in the first dorsal interosseous muscle at rest and during 5 and 30% of maximal voluntary contraction into index finger abduction in individuals with chronic cervical incomplete SCI and aged-matched control participants. We found higher persistence (number of F waves present in each set) and amplitude of F waves at rest in SCI compared with control participants. With increasing levels of voluntary contraction, the amplitude, but not the persistence, of F waves increased in both groups but to a lesser extent in SCI compared with control participants. Similarly, the CMEP amplitude increased in both groups but to a lesser extent in SCI compared with controls. These results were also found at matched absolutely levels of electromyographic activity, suggesting that these changes were not related to decreases in voluntary motor output after SCI. F-wave and CMEP amplitudes were positively correlated across conditions in both groups. These results support the hypothesis that the responsiveness of the motoneuron pool during voluntary activity decreases following SCI, which could alter the generation and strength of voluntary muscle contractions. NEW & NOTEWORTHY How the excitability of motoneurons changes during voluntary muscle activity in humans with spinal cord injury (SCI) remains poorly understood. We found that F-wave and cervicomedullary motor-evoked potential amplitude, outcomes reflecting motoneuronal excitability, increased during voluntary activity compared with rest in SCI participants but to a lesser extent that in controls. These results suggest that the responsiveness of motoneurons during voluntary activity decreases following SCI, which might affect functionally relevant plasticity after the injury.
Liturgical Commemorations, Political Dissent and Religious Schism in the Russian Orthodox Church during the 1920s and 1930s
Authors: Dockham Carol 
Published: August 2019

Abstract
In the early Soviet period, the long Christian tradition of praying for secular and ecclesiastical rulers played an important role in Orthodox debates over legitimate authority, especially after the death of Patriarch Tikhon (Bellavin, 1865–1925) in March 1925. When Metropolitan Sergii (Stragorodskii, 1867–1944), the acting leader of the patriarchal church, ordered the liturgical commemoration of the atheistic Soviet government as the secular authority and himself as the ecclesiastical authority in October 1927, he immediately provoked strong resistance from a group of hierarchs, clergy and laypersons in Leningrad. Because this opposition was expressed publicly at worship services, the Bolsheviks considered it a form of anti-Soviet agitation. For Orthodox believers, however, commemoration represented an ecclesiastical rather than a secular question. Sergii himself resisted Soviet pressure to stop commemorating his own superior, the imprisoned Metropolitan Petr (Polianskii, 1862–1937). Despite the bitter divisions among the followers of Patriarch Tikhon in the decade that followed his death, both Sergii and his opponents both prayed for Petr – a fragile thread that united the church’s contending factions.
Icons in the Lived Experience of American Orthodox Christians
Authors: Slagle Amy A. 
Published: August 2019

Abstract
This article explores how American Orthodox Christians today use and interpret icons in the course of their everyday devotional lives. Drawing upon ethnographic data collected through participant observation and interviews with parishioners of an Orthodox Church in Mississippi in 2015, I highlight the ways that diverse and multiple media within a wider American context of “buffet-style” spiritual appropriation affect informant considerations of and interactions with icons. Fundamental to this article is the tension between informants’ experiences with icons as the conveyance of divine “presence” and the concerns they express over the extent to which American commodification and mass-media cultures threaten the status and sacrality of images in Orthodox devotional practice.
LongRunMIP: Motivation and Design for a Large Collection of Millennial-Length AOGCM Simulations
Authors: Rugenstein Maria , Bloch-Johnson Jonah , Abe-Ouchi Ayako , Andrews Timothy , Beyerle Urs , Cao Long , Chadha Tarun , Danabasoglu Gokhan , Dufresne Jean-Louis , Duan Lei , Foujols Marie-Alice , Frölicher Thomas , Geoffroy Olivier , Gregory Jonathan , Knutti Reto , Li Chao , Marzocchi Alice , Mauritsen Thorsten , Menary Matthew , Moyer Elisabeth , Nazarenko Larissa , Paynter David , Saint-Martin David , Schmidt Gavin A. , Yamamoto Akitomo , Yang Shuting 
Published: August 2019

AbstractWe present a model intercomparison project, LongRunMIP, the first collection of millennial-length (1,000+ years) simulations of complex coupled climate models with a representation of ocean, atmosphere, sea ice, and land surface, and their interactions. Standard model simulations are generally only a few hundred years long. However, modeling the long-term equilibration in response to radiative forcing perturbation is important for understanding many climate phenomena, such as the evolution of ocean circulation, time- and temperature-dependent feedbacks, and the differentiation of forced signal and internal variability. The aim of LongRunMIP is to facilitate research into these questions by serving as an archive for simulations that capture as much of this equilibration as possible. The only requirement to participate in LongRunMIP is to contribute a simulation with elevated, constant CO2 forcing that lasts at least 1,000 years. LongRunMIP is an MIP of opportunity in that the simulations were mostly performed prior to the conception of the archive without an agreed-upon set of experiments. For most models, the archive contains a preindustrial control simulation and simulations with an idealized (typically abrupt) CO2 forcing. We collect 2D surface and top-of-atmosphere fields and 3D ocean temperature and salinity fields. Here, we document the collection of simulations and discuss initial results, including the evolution of surface and deep ocean temperature and cloud radiative effects. As of October 2019, the collection includes 50 simulations of 15 models by 10 modeling centers. The data of LongRunMIP are publicly available. We encourage submissions of more simulations in the future.
Convection Initiation Aided by Lake-Breeze Convergence over the Niagara Peninsula
Authors: Wang Chun-Chih , Kirshbaum Daniel J. , Sills David M. L. 
Published: August 2019

AbstractObservations from the 2015 Environment and Climate Change Canada Pan/Parapan American Science Showcase (ECPASS) and real-case, cloud-resolving numerical simulations with the Weather Research and Forecasting (WRF) Model are used to investigate two cases of moist convection forced by lake-breeze convergence over southern Ontario (18 July and 15 August 2015). The two cases shared several characteristics, including high pressure conditions, similar morning soundings, and isolated afternoon convection along a line of lake-breeze convergence between Lakes Erie and Ontario. However, the convection was significantly stronger in the August case, with robustly deeper clouds and larger radar reflectivities than in the July case. Synoptic and mesoscale analyses of these events reveal that the key difference between them was their large-scale forcing. The July event exhibited a combination of strong warm advection and large-scale descent at midlevels (850–650 hPa), which created an inversion layer that capped cloud tops at 4–6 km. The August case exhibited similar features (large-scale descent and warm advection), but these were focused at higher levels (700–400 hPa) and weaker. As a consequence, the convection in the August case was less suppressed at midlevels and ascended deeper (reaching over 8 km). Although the subcloud updraft along the lake-breeze convergence zone was also found to be stronger in the August case, this difference was found to be an effect, rather than a cause, of stronger moist convection within the cloud layer.
On the Conceptualization of Criminal Capital
Authors: Nguyen Holly 
Published: August 2019

Objectives: The first objective of this study is to provide a conceptualization of criminal capital. The second objective is to present an illustrative analysis of dimensionality and concurrent validity of criminal capital acquired in prison. Methods: One hundred eight inmates in three correctional reentry facilities in a mid-Atlantic state were interviewed at two times: in prison and nine months postrelease. Postrelease interviews included six items that tapped into criminal human capital and criminal social capital acquired in prison. Factor structure was examined with confirmatory factor analysis, and item response theory was used to examine each of the items. Regression models examined concurrent validity for the criminal capital construct on the willingness to offend, perceived rewards to crime, illegal earnings expectations, and making money from crime. Results: Criminal human capital and criminal social capital acquired in prison represent a single unidimensional latent construct. Regression models demonstrated concurrent validity for the criminal capital construct. Conclusions: Working toward a consistent conceptualization of criminal capital is important for a cohesive body of knowledge. Future work should investigate how dimensionality and validity differ across contexts.
Babao Dan induces gastric cancer cell apoptosis via regulating MAPK and NF-κB signaling pathways
Authors: Shang Haixia , Cao Zhiyun , Zhao Jinyan , Guan Jianhua , Liu Jianxin , Peng Jun , Chen Youqin , Joseph Sferra Thomas , Sankararaman Senthilkumar , Lin Jiumao 
Published: August 2019

Objective The objective was to further investigate apoptosis induction by Babao Dan (BBD), which supports its anti-tumor mechanisms, using two human gastric cancer cell lines (AGS and MGC80-3). Methods After treatment with various BBD concentrations, cell viability and cytotoxic effects were investigated using methyl thiazolyl tetrazolium (MTT) and lactate dehydrogenase (LDH) assays, respectively. The following indicators of cell apoptosis were evaluated: Annexin V-APC staining, caspase-3/-8/-9 activation, and mitochondrial membrane potential loss. Apoptosis-related protein levels (including Bcl-2-associated X protein [Bax], B-cell CLL/lymphoma 2 [Bcl-2], factor associated suicide [Fas], and Fas ligand [FasL]) were determined by western blot. The following multi-pathway factors were also assessed: p-ERK1/2, p-JNK, p-p38, and p-NF-κB. Results The MTT and LDH assays both demonstrated increased BBD cytotoxicity. BBD induced cell apoptosis by stimulating caspase-3/-8/-9 activity and destroying the mitochondrial membrane potential. BBD also regulated key factor expression levels including Bcl-2, Bax, Fas, and FasL and down-regulated protein phosphorylation via the MAPK and NF-κB pathway. Conclusions The possible anti-tumor mechanism is that BBD induces apoptosis via the MAPK and NF-κB signaling pathways.