bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggregation but Not Organo‐Metal Complexes Contributed to C Storage in Tidal Freshwater Wetland Soils
Authors: Maietta Christine E. , Bernstein Zachary A. , Gaimaro Joshua R. , Buyer Jeffrey S. , Rabenhorst Martin C. , Monsaint-Queeney Victoria L. , Baldwin Andrew H. , Yarwood Stephanie A. 
Published: February 2019

Core Ideas
Water‐stable aggregates may assist in the preservation of organic carbon in wetland soils.
Soil C was more evenly distributed among the aggregate‐size classes in the restored but not the natural site.
Macroaggregate‐C more closely resembled plan detritus whereas mineral‐C was enriched with N‐containing compounds.
One of the many goals of wetland restoration is to promote the long‐term storage of carbon (C) in the terrestrial biosphere. Unfortunately, soil C reservoirs in restored wetlands are slow to accumulate even after hydrology and plant communities are reestablished. Oftentimes wetland restoration changes the soil matrix and thus can dramatically alter how soil C is stored and processed. Our research investigated whether soil organic matter (SOM) preservation theories derived from studies in non‐wetland soil systems can be extended to wetland soils. We examined C associated with water‐stable soil aggregates, minerals, and metal oxides within habitats of one natural and one restored tidal freshwater wetland. This study revealed that a majority of the soil C in the natural site was associated with large macroaggregates (>2000 μm), and soils from the restored site stored more C in small macroaggregates (≥250 to <2000 μm). Despite these different associations, the chemical composition of SOM followed similar patterns across each aggregate‐size class. Results from the sequential extraction procedure suggest organo‐metal oxide complexes do not contribute to C stabilization in these habitats. This research is one of the few studies that have examined C stabilization related to soil structure in wetland soils. Our results suggest soil aggregate formation may be an important mechanism driving C stabilization, and that disruption to macroaggregates may limit C accumulation in restored wetlands. Additional empirical research and long‐term field monitoring are needed to confirm linkages between aggregate‐C stabilization and accumulation in wetland soils.
Cover Crops and Corn Residue Removal: Impacts on Soil Hydraulic Properties and Their Relationships with Carbon
Authors: Sindelar Michael , Blanco-Canqui Humberto , Jin Virginia L. , Ferguson Richard 
Published: February 2019

Core Ideas
Cover crop generally had no effect on water infiltration, water retention, and available water after 5 and 6 yr.
Corn residue removal reduced water infiltration, water retention, and available water after 5 and 6 yr.
Cover crop partially mitigated the negative impacts of corn residue removal on soil hydraulic properties.
Reductions in soil micropores and soil C concentration due to corn residue removal partly explained the reduction in plant‐available water.
Large‐scale crop residue removal may negatively affect soil water dynamics. Integrating cover crop (CC) with crop residue management can be a strategy to offset potential adverse effects of residue removal. We studied: (i) the impact of corn (Zea mays L.) residue removal (56%) with and without the use of winter rye (Secale cereale L.) CC on soil hydraulic properties, (ii) whether CC would ameliorate residue removal effects on hydraulic properties, and (iii) relationships of hydraulic properties with soil organic C (SOC) and other properties under irrigated no‐till continuous corn on a silt loam in south central Nebraska after 5 and 6 yr of management. Cover crops did not affect soil hydraulic properties. However, residue removal reduced cumulative water infiltration by about 45% in one year. Across years, residue removal reduced plant available water (PAW) by 32% and mean weight diameter of water‐stable aggregates (MWD) by 23% for the upper 5‐cm soil depth. Under no CC, residue removal reduced SOC concentration by 25% in the 0‐ to 5‐cm and by 11% in the 5‐ to 10‐cm depths. Under residue removal, CC increased SOC concentration by 18% in the 0‐ to 5‐cm and by 8% in the 5 to 10‐cm depths. Cover crop did not completely offset the residue removal‐induced decrease in SOC concentration in the upper 5‐cm depth. Plant available water decreased as SOC concentration and MWD decreased. After 6 yr, corn residue removal adversely affected soil hydraulic properties and SOC concentration, but CC was unable to fully offset such adverse impacts.
Intracranial Aneurysms in Sickle Cell Disease
Authors: Jabbarli Ramazan , Dinger Thiemo F. , Pierscianek Daniela , Oppong Marvin D. , Chen Bixia , Dammann Philipp , Wrede Karsten H. , Kaier Klaus , Köhrmann Martin , Forsting Michael , Kleinschnitz Christoph , Sure Ulrich 
Published: February 2019

Background:
The exact causes of intracranial aneurysms (IAs) are still unknown. However,
certain diseases are known to be associated with IAs.

Objective:
To analyze the differences in IA characteristics in the general population and in
individuals with sickle-cell disease (SCD).

Methods:
We systematically searched PubMed, Scopus, Web of Science, and Cochrane Library
for Data on SCD patients with IAs. We compared IA characteristics of SCD patients with those
from 2451 healthy IA carriers from our observational cohort.

Results:
129 SCD patients with IAs were identified in 42 studies. The SCD patient cohort was
characterized by younger age (mean 27.1 vs 54.9 years, p<0.0001) and lower female prevalence
(57.7% vs 68.4%, p=0.0177). The prevalence (47% vs 34.5%, p=0.004) and the number (3.02 vs
2.56 IAs/patient, p=0.004) of multiple IAs were also higher in the SCD cohort. Unruptured IAs
(3.27 vs 6.16 mm, p<0.0001), but not ruptured IAs (7.8 vs 7.34 mm, p=0.9086) were significantly
smaller in the SCD cohort. In addition, IAs were more frequently located in the internal carotid artery
(45% vs 29%, p<0.0001) or posterior circulation (43% vs 20%, p<0.0001). Higher age (≥30
years, p=0.007), IA size ≥7 mm (p=0.008), and location in posterior circulation (p=0.01) were independently
associated with subarachnoid hemorrhage in SCD.

Conclusion:
There is a distinct demographic and radiographic pattern of IA in SCD. Risk factors
for IA rupture in SCD are mostly congruent with those in healthy individuals.
Glucose Levels and Outcome After Primary Intraventricular Hemorrhage
Authors: Guo Rui , Chen Ruiqi , You Chao , Ma Lu , Li Hao , Fang Yuan 
Published: February 2019

Background and Purpose:
Hyperglycemia is reported to be associated with poor outcome
in patients with spontaneous Intracerebral Hemorrhage (ICH), but the association between
blood glucose level and outcomes in Primary Intraventricular Hemorrhage (PIVH) remains unclear.
We sought to identify the parameters associated with admission hyperglycemia and analyze
the impact of hyperglycemia on clinical outcome in patients with PIVH.

Methods:
Patients admitted to Department of Neurosurgery, West China Hospital with PIVH between
2010 and 2016 were retrospectively included in our study. Clinical, radiographic, and laboratory
data were collected. Univariate and multivariate logistic regression analyses were used to
identify independent predictors of poor outcomes.

Results:
One hundred and seventy patients were included in the analysis. Mean admission blood
glucose level was 7.78±2.73 mmol/L and 10 patients (5.9%) had a history of diabetes mellitus.
History of diabetes mellitus (P = 0.01; Odds Ratio [OR], 9.10; 95% Confidence Interval [CI], 1.64
to 50.54) was independent predictor of admission critical hyperglycemia defined at 8.17 mmol/L.
Patients with admission critical hyperglycemia poorer outcome at discharge (P < 0.001) and 90
days (P < 0.001). After adjustment, admission blood glucose was significantly associated with discharge
(P = 0.01; OR, 1.30; 95% CI, 1.06 to 1.59) and 90-day poor outcomes (P = 0.03; OR, 1.27;
95% CI, 1.03 to 1.58), as well as mortality at 90 days (P = 0.005; OR, 1.41; 95% CI, 1.11 to 1.78).
In addition, admission critical hyperglycemia showed significantly increased the incidence rate of
pneumonia in PIVH (P = 0.02; OR, 6.04; 95% CI 1.27 to 28.80) even after adjusting for the confounders.

Conclusion:
Admission blood glucose after PIVH is associated with discharge and 90-day poor
outcomes, as well as mortality at 90 days. Admission hyperglycemia significantly increases the
incidence rate of pneumonia in PIVH.
Tyrosine Kinase Inhibitor-Induced Hypertension: Role of Hypertension as a Biomarker in Cancer Treatment
Authors: Budolfsen Cecilie , Faber Julie , Grimm Daniela , Krüger Marcus , Bauer Johann , Wehland Markus , Infanger Manfred , Magnusson Nils Erik 
Published: February 2019

:Cancer treatment is an area of continuous improvement. Therapy is becoming more targeted and the use of anti-angiogenic agents in multiple cancers, specifically tyrosine kinase inhibitors (TKIs), has demonstrated prolonged survival outcomes compared with previous drugs. Therefore, they have become a well-established part of the treatment.:Despite good results, there is a broad range of moderate to severe adverse effects associated with treatment. Hypertension (HTN) is one of the most frequent adverse effects and has been associated with favourable outcomes (in terms of cancer treatment) of TKI treatment.:High blood pressure is considered a class effect of TKI treatment, although the mechanisms have not been fully described. Three current hypotheses of TKI-associated HTN are highlighted in this narrative review. These include nitric oxide decrease, a change in endothelin-1 levels and capillary rarefaction.:Several studies have investigated HTN as a potential biomarker of TKI efficacy. HTN is easy to measure and adding this factor to prognostic models has been shown to improve specificity. HTN may become a potential biomarker in clinical practice involving treating advanced cancers. However, data are currently limited by the number of studies and knowledge of the mechanism of action.
From Antimicrobial to Anticancer Peptides: The Transformation of Peptides
Authors: Qin Yuan , Qin Zuo D. , Chen Jing , Cai Che G. , Li Ling , Feng Lu Y. , Wang Zheng , Duns Gregory J. , He Nong Y. , Chen Zhe S. , Luo Xiao F. 
Published: February 2019

Background: Antimicrobial peptides play an important role in the innate immune system. Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat and kill various targets, including gram-negative bacteria, gram-positive bacteria, fungi, and tumor cells.Objective:An overview of the state of play with regard to the research trend of antimicrobial peptides in recent years and the situation of targeting tumor cells, and to make statistical analysis of the patents related to anticancer peptides published in recent years, is important both from toxicological and medical tumor therapy point of view.Methods:Based on the Science Citation Index Expanded version, the Derwent Innovation Index and Innography as data sources, the relevant literature and patents concerning antimicrobial peptides and anticancer peptides were analyzed through the Thomson Data Analyzer. Results of toxicologic and pharmacologic studies that brought to the development of patents for methods to novel tumor drugs were analyzed and sub-divided according to the specific synthesis of anticancer peptides.Results:The literature and patent search data show that the research and development of global antimicrobial peptides and anticancer peptides has been in an incremental mode. Growing patent evidence indicate that bioinformatics technology is a valuable strategy to modify, synthesize or recombine existing antimicrobial peptides to obtain tumor drugs with high activity, low toxicity and multiple targets.Conclusion:These findings may have important clinical implications for cancer treatment, especially in patients with conditions that are not currently treatable by other drugs, or that are resistant to existing cancer drugs.
Seeds, Leaves and Roots of Thapsia garganica as a Source of New Potent Lipases Inhibitors: In vitro and In silico Studies
Authors: Nebeg Halima , Benarous Khedidja , Serseg Talia , Lazreg Asma , Hassani Hafidha , Yousfi Mohamed 
Published: February 2019

Background and Objective:
Lipase inhibitors have gained great interest because they could
help in the therapy of many diseases, however, unfortunately, only a few drugs are currently available
on the market. Therefore, the aim of this work was to evaluate for the first time the lipase inhibition
effect of Thapsia garganica extracts from seeds, leaves and roots.

Methods:
Polyphenols and flavonoids contents were determined using spectrophotometric method.
Inhibitory activity of ethyl acetate extracts from seeds, leaves and roots of T. garganica against Candida
rugosa lipase was determined. To uncover the active constituents responsible for this anti-lipase
activity, further investigations were performed by employing theoretical docking simulations, using
AutoDock Vina program to discuss the nature of interactions and the inhibition mechanism by major
bioactive compounds synthesized by this plant.

Results:
Seeds, leaves and roots extracts of T. garganica showed appreciable contents of polyphenols
and flavonoids which is most in seeds extract with 2.90±0.02mg GAE/gdw and 1.53±0.05mg QE/gdw,
respectively. Hence, their inhibitory activities against Candida rugosa lipase were determined as IC50
of 1.19mg/ml, 1.96mg/ml and 1.87mg/ml, respectively. Docking simulations have shown that
nortribolid and tribolid are best inhibitors for both lipases (Candida rugosa and human pancreatic lipases).

Conclusion:
Testing the anti-lipase activity of the ethyl acetate extracts of T. garganica revealed a
potent lipase inhibition activity, which suggests the use of these molecules as anti-obesity drugs.
AU Content in the MicroRNA Sequence Influences its Stability after Heat Treatment
Authors: López Agnès Garcias , Brogaard Louise , Heegaard Peter Mikail Helwag , Cirera Susanna , Skovgaard Kerstin 
Published: February 2019

Background:
MicroRNAs (miRNAs) are short non-coding RNA molecules which regulate
gene expression post-transcriptionally and are involved in a multitude of cellular processes.
MiRNAs are known to be very stable compared to messenger RNAs (mRNAs), making them excellent
candidates as biomarkers for disease. Recently, studies have suggested that miRNA stability in
formalin fixed samples might depend on their nucleotide composition.

Objective:
To explore the stability of a panel of miRNAs isolated from porcine blood and lung tissue
after heat and enzyme treatment.

Method:
Porcine RNA isolated from lung tissue and blood leukocytes was used for this study. RNA
samples were exposed to heat treatment and RNAse A digestion. The levels of selected miRNAs
were measured by means of qPCR before and after heat and enzyme treatment.

Results:
Fourteen miRNAs were successfully analysed, and they were found to degrade differently
after exposure to heat or RNAse A. MiRNAs with <60% of adenine (A) and uracil (U) in their sequence
were found to be more stable.

Conclusion:
This is the first study showing that different miRNAs isolated from lung tissue display
unequal stability after heat treatment, probably based on their nucleotide composition, highlighting
the importance of considering the miRNA sequence when investigating their value as biomarkers.
IMSTeP : Indonesian Marine Science And Techno Park Implementasi Kebijakan Model Van Meter Dan Van Horn Di Indonesia
Authors: Kurniawan Riki , Alexandri M. Benny , Nurasa Heru 
Published: February 2019

Abstract The marine resources are waiting for the nation's explorer. Government support and past glory should be a giant step to develop real marine sector support programs. The nations assets supporting facilities and infrastructure of maritime science and technology sector is important to be considered for the efficiency of cost and expenditure of state and the progress of science and technology in the field of Marine.Pra feasibility that has been done, after the formation of Team Work and the support from central government collaboration across Ministries and Research Institutions, also supported by government readiness areas within the development of the Indonesia Marine Science and Technology Center (IMSTeP) should be a solid and well-maintained cooperation. The policy issued by the government is required to be able to cover every progress. However whether the policy can be implemented well operationally and substansinya or still need support derivative policies or other bureaucratic obstacles that need to be anticipated to accelerate the progress of this national program so that we soon become Master in his own country in the inner sector in particular ,,,, JalesvevaJayamahe. Abstrak Sumberdaya kelautan yang berlimpah menunggu para explorer anak bangsa untuk bergerak. Dukungan Pemerintah dan kejayaan masa lalu seharusnya menjadi cermin untuk mengembangkan program riil pendukung sektor kelautan khususnya. Aset pendukung sarana dan prasarana iptek sektor kelautan penting untuk diperhatikan demi efisiensi cost dan pengeluaran negara serta kemajuan Iptek di bidang Kelautan.Pra feasibility yang sudah dilakukan, setelah pembentukan Tim Pokja serta dukungan kolaborasi pemerintah pusat lintas Kementerian dan Lembaga Penelitian, di dukung oleh kesiapan pemerintah daerah didalam pengembangan Pusat Iptek Kelautan (IMSTeP) harus menjadi satu kerjasama yang solid dan terpelihara. Kebijakan yang dikeluarkan pemerintah dituntut mampu memayungi setiap progress kemajuannya.Namun apakah kebijakan tersebut dapat terimplementasikan dengan baik secara operasional dan substansinya atau masih perlukah dukungan kebijakan turunannya atau kendala birokrasi lain yang perlu segera di antisipasi untuk mempercepat progress progam nasional ini sehingga dengan segera kita menjadi Tuan di Negeri Sendiri di sektor keluatan khususnya,,,, JalesvevaJayamahe.
Perceptions towards healthy diet of the Portuguese according to area of work or studies
Authors: Ferrão Ana Cristina , Correia Paula , Ferreira Manuela , Guiné Raquel P. F. 
Published: February 2019

Abstract

Introduction
A healthy diet is crucial for the maintenance of health. Therefore, the aim of this work is to evaluate the perceptions towards a healthy diet among the participants with work or studies in areas related to diet and nutrition and those who did not.

Methods
Anonymous questionnaire data was collected in a cross-sectional study on a non-probabilistic sample of 902 participants living in Portugal.

Results
The results showed that the participants’ perceptions were, in general, compliant with a healthy diet. However, significant differences were found between gender (p=0.004), between the different civil state groups (p=0.016), between the participants who were responsible for buying their own food and those who were not and also regarding the living environment. The variable area of work or studies also showed significant differences (p=0.001), so that people who had work or studies related to agriculture obtained a higher score. Regarding this variable, the mean values of nutrition and agriculture areas were not statistically different between them, but were statistically different from the mean values of psychology and health areas. The participants who had work or studies in areas showing diet and nutrition-related issues achieved a higher mean score (0.72±0.35) when compared to the participants who did not (0.58±0.30).

Conclusion
However, despite the results, it is important to continue developing campaigns that better communicate nutritional aspects, so that people can increase their knowledge on this subject.
Spinal epidural lipomatosis due to adrenal cortisol secreting adenoma in a 14-year-old girl. A case report
Authors: Bajracharya Luna , Berend Kenrick 
Published: February 2019

Background:
Spinal epidural lipomatosis (SEL) is an excessive fat deposition within the epidural space of spinal canal leading to compression of nervous structures and neurological manifestations. Exogenous glucocorticoid administration is the major cause of symptomatic SEL. The reported patient had SEL related to endogenous Cushing syndrome, which is among a few reported cases in the literature.

Case Presentation:
A 14-year-old girl with features of Cushing syndrome had severe back pain and the magnetic resonance imaging of the spine showed SEL. Subsequently, computed tomography of the abdomen showed right adrenal adenoma. The patient underwent adrenalectomy which improved her signs of hypercortisolism and SEL.

Conclusion:
In view of severe neurological deficits and therapeutic consequences, SEL should be considered in all patients with Cushing syndrome who present with symptoms of spinal cord compression. Correction of underlying endocrinopathy is imperative in the management of SEL.
Severe hyponatremia as a presenting sign of panhypopituitarism due to non-functioning pituitary adenoma: a case report
Authors: Mehmood Faryal , Ashfaq Anum , Beg Muhammad Atif 
Published: February 2019

Background:
Hyponatremia is the commonest electrolyte imbalance, which is seen especially in elderly patients presenting in the emergency department of hospitals. There is a wide range of differentials in hyponatremic patients but it can be the initial sign of pituitary disease, specifically in the old age population. Diagnosis can often be challenging because symptoms can be attributed to the normal aging process and a high index of clinical suspicion is necessary.

Case Presentation:
Here, we present the case of a 61-year-old female presented in our facility with a history of vomiting, drowsiness, and fatigue for 2 days before admission. On investigating, serum electrolytes showed hyponatremia. CXR was also normal. As the patient was not in fluid overload, so our differentials based on euvolemic hyponatremia included syndrome of inappropriate anti-diuretic hormone secretion (SIADH), severe hypothyroidism, or glucocorticoid insufficiency. Urine osmolarity was not in range of SIADH. Serum cortisol was normal. Follicle stimulating hormone (FSH), Leutinizing hormone (LH), estrogen, and progesterone were low although these should be high as the patient was post-menopausal. Prolactin was normal. magnetic resonance imaging (MRI) brain with contrast showed supra and intrasellar mass consistent with a pituitary macroadenoma.

Conclusion:
Depending on presentation and investigations, non-functioning pituitary adenoma (NFPA) presenting with panhypopituitarism complicated by hyponatremia was the final diagnosis. Our case highlights the importance of diagnosing NFPA in elderly patients who present with hyponatremia, which can often be challenging and should not be delayed as this is life-saving; hence, targeted treatment should be started as soon as possible.