bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental factors may influence interseeded annual ryegrass and red clover establishment and growth more than soil residual herbicide applications
Authors: Stanton Victoria L. , Haramoto Erin R. 
Published: March 2019

AbstractIntegrating multiple weed management (cultural, physical, chemical) strategies is often recommended to combat herbicide resistance. With the increased use of interseeded cover crops, the effects of PRE herbicides on their establishment and growth require study. An investigation was conducted in Lexington, KY, in 2016 through 2018 to assess the extent to which commonly used PRE corn herbicide combinations influenced interseeded red clover and annual ryegrass establishment and growth. Annual ryegrass density was reduced 29% at 3 wk after interseeding by the combination of residual dimethenamid-P and atrazine; however, biomass the following spring was not affected by herbicide combinations. Neither density of interseeded red clover at 2 to 3 wk after interseeding nor biomass prior to termination the following spring were influenced by herbicide combinations. However, red clover density was affected by herbicide treatment 5 wk after interseeding in 2016. These results could have been influenced by low summer survival, particularly in 2016. The environmental factors may have influenced the survival of the interseeded cover crops more than the PRE herbicides. This study suggests that multiple PRE herbicides can be used with minimal risk to interseeded red clover or annual ryegrass. However, the influence of the environment on establishment and survival of interseeded cover crops following the use of PRE herbicides requires further study.
Preliminary Evaluation of the Atmospheric Infrared Sounder Water Vapor Over China Against High‐Resolution Radiosonde Measurements
Authors: Zeng Zhaoliang , Mao Feiyue , Wang Zemin , Guo Jianping , Gui Ke , An Jiachun , Yim Steve Hung Lam , Yang Yuanjian , Zhang Baojun , Jiang Hu 
Published: March 2019

AbstractThe accuracy of the Atmospheric Infrared Sounder (AIRS) water vapor product in China is as yet unknown due to the lack of collocated in situ sounding observations. Based on high‐resolution soundings at 1400 Beijing time from 113 radiosonde sites across China, along with the Moderate Resolution Imaging Spectroradiometer (MODIS) and the Global Positioning System (GPS) data sets, a preliminary assessment has been conducted of AIRS water vapor mixing ratio (q) and precipitable water vapor (PWV) products in June 2013 and June 2014. Comparison between AIRS and radiosonde data suggests that the correlation coefficient (R) and mean bias of these two q products in China exhibit a distinct geographical dependence (with the highest R values in northwest China). This suggests that the AIRS q product tends to be underestimated in southeast China where cloud cover prevails, but overestimated in northwest China where cloud cover is sparse. With regard to the height‐resolved distribution, the q products from both AIRS and radiosondes tend to decrease with increasing altitude, irrespective of the particular region. The spatial distribution of AIRS PWV is consistent with that from radiosonde‐derived PWV, except in south China where the AIRS PWV data set is considerably underestimated. The accuracy of the AIRS water vapor product tends to be impaired under highly cloudy conditions, corroborating the notion of clouds affecting the retrieval of AIRS PWV. Our findings highlight the importance of afternoon sounding measurements in validating AIRS data and call for the improved understanding of the role of water vapor in the context of global climate change.
Oblique Reflections of Mars Express MARSIS Radar Signals From Ionospheric Density Structures: Raytracing Analysis
Authors: Němec F. , Andrews D. J. , Morgan D. D. , Kopf A. J. , Gurnett D. A. 
Published: March 2019

AbstractMars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS) radar sounder on board the Mars Express spacecraft revealed oblique reflections coming systematically from apparently stable density structures in the Martian ionosphere. Although these were typically interpreted by assuming a straight line propagation of the sounding signal at the speed of light, the ionospheric plasma is clearly a dispersive medium. Consequently, the ray propagation paths may be significantly bent, and, moreover, the observed time delays need to be interpreted in terms of realistic group velocities of the signal propagation. We select a single particularly well‐pronounced event with oblique reflections observable over a large range of signal frequencies, and we employ raytracing calculations to perform its detailed analysis. An isolated density structure responsible for the reflection of the sounding signal back to the spacecraft is assumed, and the relevant ionospheric signal propagation is properly evaluated. We show that initially oblique sounding signals get progressively more oblique during their propagation, imposing an upper threshold on the angular propagation distance between the spacecraft and the reflecting density structure, in line with the observations. Considering realistic propagation paths further allows us to explain the frequency dependence of the observed time delays and to accurately model the entire event. The obtained results are consistent with the spacecraft passing very close to a spatially limited density structure. We also show that the results obtained using realistic raytracing calculations are significantly different from the results obtained using additional simplifying assumptions.
Ground, Proximal, and Satellite Remote Sensing of Soil Moisture
Authors: Babaeian Ebrahim , Sadeghi Morteza , Jones Scott B. , Montzka Carsten , Vereecken Harry , Tuller Markus 
Published: March 2019

AbstractSoil moisture (SM) is a key hydrologic state variable that is of significant importance for numerous Earth and environmental science applications that directly impact the global environment and human society. Potential applications include, but are not limited to, forecasting of weather and climate variability; prediction and monitoring of drought conditions; management and allocation of water resources; agricultural plant production and alleviation of famine; prevention of natural disasters such as wild fires, landslides, floods, and dust storms; or monitoring of ecosystem response to climate change. Because of the importance and wide‐ranging applicability of highly variable spatial and temporal SM information that links the water, energy, and carbon cycles, significant efforts and resources have been devoted in recent years to advance SM measurement and monitoring capabilities from the point to the global scales. This review encompasses recent advances and the state‐of‐the‐art of ground, proximal, and novel SM remote sensing techniques at various spatial and temporal scales and identifies critical future research needs and directions to further advance and optimize technology, analysis and retrieval methods, and the application of SM information to improve the understanding of critical zone moisture dynamics. Despite the impressive progress over the last decade, there are still many opportunities and needs to, for example, improve SM retrieval from remotely sensed optical, thermal, and microwave data and opportunities for novel applications of SM information for water resources management, sustainable environmental development, and food security.
A Race Against Time: Modeling Time Lags in Watershed Response
Authors: Ilampooranan Idhayachandhiran , Van Meter K. J. , Basu Nandita B. 
Published: March 2019

AbstractLand use change and agricultural intensification have increased food production but at the cost of polluting surface and groundwater. Best management practices implemented to improve water quality have met with limited success. Such lack of success is increasingly attributed to legacy nutrient stores in the subsurface that may act as sources after reduction of external inputs. However, current water‐quality models lack a framework to capture these legacy effects. Here we have modified the SWAT (Soil Water Assessment Tool) model to capture the effects of nitrogen (N) legacies on water quality under multiple land‐management scenarios. Our new SWAT‐LAG model includes (1) a modified carbon‐nitrogen cycling module to capture the dynamics of soil N accumulation, and (2) a groundwater travel time distribution module to capture a range of subsurface travel times. Using a 502‐km2 Iowa watershed as a case study, we found that between 1950 and 2016, 25% of the total watershed N surplus (N Deposition + Fertilizer + Manure + N Fixation − Crop N uptake) had accumulated within the root zone, 14% had accumulated in groundwater, while 27% was lost as riverine output, and 34% was denitrified. In future scenarios, a 100% reduction in fertilizer application led to a 79% reduction in stream N load, but the SWAT‐LAG results suggest that it would take 84 years to achieve this reduction, in contrast to the 2 years predicted in the original SWAT model. The framework proposed here constitutes a first step toward modifying a widely used modeling approach to assess the effects of legacy N on the time required to achieve water‐quality goals.
Synchronous Strengthening of the Indian and East Asian Monsoons in Response to Global Warming Since the Last Deglaciation
Authors: Jiang Wenying , Leroy Suzanne A.G. , Yang Shiling , Zhang Enlou , Wang Luo , Yang Xiaoxiao , Rioual Patrick 
Published: March 2019

AbstractThe responses of the Indian and East Asian summer monsoons (ISM and EASM) to warming since the last deglaciation are controversial. Pollen results from a subalpine lake in the ISM area show that the Tsuga dumosa forest zone migrated at least 650 m upward during 18.6–7.1 kyr BP, indicating a gradual rise in mean annual temperature exceeding 3.9 °C. In response, grasses and deciduous and evergreen broad‐leaved trees successively colonized the mountainous environment. By contrast, the area around a lake in the EASM area was gradually occupied by temperate deciduous trees. In both areas, the maximum monsoonal precipitation occurred during 7.1–6.4 kyr BP, coinciding with peak Holocene warmth, but lagging the peak in Northern Hemisphere summer insolation by 3.9–4.6 kyr, due to delayed ice melting in northern high latitudes. Our results indicate the synchronous strengthening of the ISM and EASM in response to warming‐induced northward shifts in the Intertropical Convergence Zone.
Concordance of genetic variation that increases risk for Tourette Syndrome and that influences its underlying neurocircuitry
Authors: Mufford Mary , Cheung Josh , Jahanshad Neda , van der Merwe Celia , Ding Linda , Groenewold Nynke , Koen Nastassja , Chimusa Emile R. , Dalvie Shareefa , Ramesar Raj , Knowles James A. , Lochner Christine , Hibar Derrek P. , Paschou Peristera , van den Heuvel Odile A. , Medland Sarah E. , Scharf Jeremiah M. , Mathews Carol A. , Thompson Paul M. , Stein Dan J. ,   Psychiatric Genomics Consortium - Tourette Syndrome working group
Published: March 2019

AbstractThere have been considerable recent advances in understanding the genetic architecture of Tourette Syndrome (TS) as well as its underlying neurocircuitry. However, the mechanisms by which genetic variation that increases risk for TS—and its main symptom dimensions—influence relevant brain regions are poorly understood. Here we undertook a genome-wide investigation of the overlap between TS genetic risk and genetic influences on the volume of specific subcortical brain structures that have been implicated in TS. We obtained summary statistics for the most recent TS genome-wide association study (GWAS) from the TS Psychiatric Genomics Consortium Working Group (4644 cases and 8695 controls) and GWAS of subcortical volumes from the ENIGMA consortium (30,717 individuals). We also undertook analyses using GWAS summary statistics of key symptom factors in TS, namely social disinhibition and symmetry behaviour. SNP effect concordance analysis (SECA) was used to examine genetic pleiotropy—the same SNP affecting two traits—and concordance—the agreement in single nucelotide polymorphism (SNP) effect directions across these two traits. In addition, a conditional false discovery rate (FDR) analysis was performed, conditioning the TS risk variants on each of the seven subcortical and the intracranial brain volume GWAS. Linkage disequilibrium score regression (LDSR) was used as validation of the SECA method. SECA revealed significant pleiotropy between TS and putamen (p = 2 × 10−4) and caudate (p = 4 × 10−4) volumes, independent of direction of effect, and significant concordance between TS and lower thalamic volume (p = 1 × 10−3). LDSR lent additional support for the association between TS and thalamus volume (p = 5.85 × 10−2). Furthermore, SECA revealed significant evidence of concordance between the social disinhibition symptom dimension and lower thalamus volume (p = 1 × 10−3), as well as concordance between symmetry behaviour and greater putamen volume (p = 7 × 10−4). Conditional FDR analysis further revealed novel variants significantly associated with TS (p < 8 × 10−7) when conditioning on intracranial (rs2708146,q = 0.046; and rs72853320,q = 0.035) and hippocampal (rs1922786,q = 0.001) volumes, respectively. These data indicate concordance for genetic variation involved in disorder risk and subcortical brain volumes in TS. Further work with larger samples is needed to fully delineate the genetic architecture of these disorders and their underlying neurocircuitry.
Ubiquitination of MAP1LC3B by pVHL is associated with autophagy and cell death in renal cell carcinoma
Authors: Kang Hyun Mi , Noh Kyung Hee , Chang Tae Kyung , Park Dongmin , Cho Hyun-Soo , Lim Jung Hwa , Jung Cho-Rok 
Published: March 2019

AbstractVon Hippel Lindau (VHL) expression is significantly decreased in high-grade RCC, and autophagy, which is involved in tumor growth, invasion, differentiation, and metastasis, is activated in various human cancers. However, the relationship of autophagy and VHL in tumor progression remains controversial. Here, we showed that the expression levels of VHL and microtubule-associated protein 1 light chain 3B (MAP1LC3B, LC3B) were inversely correlated with various tumor grades of RCC tissues. pVHL was found to possess the LIR motif within a beta domain that interacted with MAP1LC3B and ubiquitinated it. The L101A VHL mutant failed to interact with MAP1LC3B, thereby failing to induce ubiquitination. MAP1LC3B-mediated autophagy was inhibited by functional pVHL and the ubiquitination of MAPLC3B was implicated in autophagy-induced cell death. We screened various autophagy inducers to determine the physiological function of the inhibition of LC3B-mediated autophagy by pVHL using VHL-deficient and VHL-expressing cell lines. MLN9708, a proteasome inhibitor, potently induced autophagy via the induction of MAP1LC3B and sensitized the cell to autophagy-mediated cell death in VHL-deficient and VHL-mutant (L101A) cells. In conclusion, our results showed that pVHL interacts with MAPL1LC3B and inhibits LC3B-mediated autophagy via MAP1LC3B ubiquitination. Furthermore, the activation of autophagy by the proteasome inhibitor MLN9708 induced cell death, indicating that MLN9708 can be used for VHL-deficient RCC therapy.
GABA inhibits proliferation and self-renewal of mouse retinal progenitor cell
Authors: Wang Shaojun , Du Lu , Peng Guanghua , Li Wei 
Published: March 2019

AbstractGamma-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the central nervous system, including the retina, and play an important role in both regulating neurogenesis and neural stem cell proliferation. GABAa receptor has been identified in the retina, however, the function of GABAa receptor on retinal progenitor cell (RPC) is unclear. RPCs were cultured to analyze changes in cell proliferation and cell cycle distribution after GABAa receptor activation. The activation of GABAa receptor significantly inhibits RPCs proliferation, cell cycle progress, and self-renewal. Moreover, the activation of GABAa receptor leads to the up-expression of p21 and p27 and down-expression of Nestin, Pax6, Sox2, and Chx10. These results suggest that GABA acts as a negative regulator of RPCs proliferation and self-renewal.
Factors controlling surface oxygen exchange in oxides
Authors: Cao Yipeng , Gadre Milind J. , Ngo Anh T. , Adler Stuart B. , Morgan Dane D. 
Published: March 2019

AbstractReducing the working temperature of solid oxide fuel cells is critical to their increased commercialization but is inhibited by the slow oxygen exchange kinetics at the cathode, which limits the overall rate of the oxygen reduction reaction. We use ab initio methods to develop a quantitative elementary reaction model of oxygen exchange in a representative cathode material, La0.5Sr0.5CoO3−δ, and predict that under operating conditions the rate-limiting step for oxygen incorporation from O2 gas on the stable, (001)-SrO surface is lateral (surface) diffusion of O-adatoms and oxygen surface vacancies. We predict that a high vacancy concentration on the metastable CoO2 termination enables a vacancy-assisted O2 dissociation that is 102–103 times faster than the rate limiting step on the Sr-rich (La,Sr)O termination. This result implies that dramatically enhanced oxygen exchange performance could potentially be obtained by suppressing the (La,Sr)O termination and stabilizing highly active CoO2 termination.
TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
Authors: Saito Hiroaki , Gasser Andreas , Bolamperti Simona , Maeda Miki , Matthies Levi , Jähn Katharina , Long Courtney L. , Schlüter Hartmut , Kwiatkowski Marcel , Saini Vaibhav , Pajevic Paola Divieti , Bellido Teresita , van Wijnen Andre J. , Mohammad Khalid S. , Guise Theresa A. , Taipaleenmäki Hanna , Hesse Eric 
Published: March 2019

AbstractOsteoporosis is caused by increased bone resorption and decreased bone formation. Intermittent administration of a fragment of Parathyroid hormone (PTH) activates osteoblast-mediated bone formation and is used in patients with severe osteoporosis. However, the mechanisms by which PTH elicits its anabolic effect are not fully elucidated. Here we show that the absence of the homeodomain protein TG-interacting factor 1 (Tgif1) impairs osteoblast differentiation and activity, leading to a reduced bone formation. Deletion of Tgif1 in osteoblasts and osteocytes decreases bone resorption due to an increased secretion of Semaphorin 3E (Sema3E), an osteoclast-inhibiting factor. Tgif1 is a PTH target gene and PTH treatment failed to increase bone formation and bone mass in Tgif1-deficient mice. Thus, our study identifies Tgif1 as a novel regulator of bone remodeling and an essential component of the PTH anabolic action. These insights contribute to a better understanding of bone metabolism and the anabolic function of PTH.
Humans can decipher adversarial images
Authors: Zhou Zhenglong , Firestone Chaz 
Published: March 2019

AbstractDoes the human mind resemble the machine-learning systems that mirror its performance? Convolutional neural networks (CNNs) have achieved human-level benchmarks in classifying novel images. These advances support technologies such as autonomous vehicles and machine diagnosis; but beyond this, they serve as candidate models for human vision itself. However, unlike humans, CNNs are “fooled” by adversarial examples—nonsense patterns that machines recognize as familiar objects, or seemingly irrelevant image perturbations that nevertheless alter the machine’s classification. Such bizarre behaviors challenge the promise of these new advances; but do human and machine judgments fundamentally diverge? Here, we show that human and machine classification of adversarial images are robustly related: In 8 experiments on 5 prominent and diverse adversarial imagesets, human subjects correctly anticipated the machine’s preferred label over relevant foils—even for images described as “totally unrecognizable to human eyes”. Human intuition may be a surprisingly reliable guide to machine (mis)classification—with consequences for minds and machines alike.
SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
Authors: Sachs Parysatis , Ding Dong , Bergmaier Philipp , Lamp Boris , Schlagheck Christina , Finkernagel Florian , Nist Andrea , Stiewe Thorsten , Mermoud Jacqueline E. 
Published: March 2019

AbstractEndogenous retroviruses (ERVs) can confer benefits to their host but present a threat to genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler SMARCAD1 as a key factor in the control of ERVs in embryonic stem cells. SMARCAD1 is enriched at ERV subfamilies class I and II, particularly at active intracisternal A-type particles (IAPs), where it preserves repressive histone methylation marks. Depletion of SMARCAD1 results in de-repression of IAPs and adjacent genes. Recruitment of SMARCAD1 to ERVs is dependent on KAP1, a central component of the silencing machinery. SMARCAD1 and KAP1 occupancy at ERVs is co-dependent and requires the ATPase function of SMARCAD1. Our findings uncover a role for the enzymatic activity of SMARCAD1 in cooperating with KAP1 to silence ERVs. This reveals ATP-dependent chromatin remodeling as an integral step in retrotransposon regulation in stem cells and advances our understanding of the mechanisms driving heterochromatin establishment.
A threonyl-tRNA synthetase-mediated translation initiation machinery
Authors: Jeong Seung Jae , Park Shinhye , Nguyen Loi T. , Hwang Jungwon , Lee Eun-Young , Giong Hoi-Khoanh , Lee Jeong-Soo , Yoon Ina , Lee Ji-Hyun , Kim Jong Hyun , Kim Hoi Kyoung , Kim Doyeun , Yang Won Suk , Kim Seon-Young , Lee Chan Yong , Yu Kweon , Sonenberg Nahum , Kim Myung Hee , Kim Sunghoon 
Published: March 2019

AbstractA fundamental question in biology is how vertebrates evolved and differ from invertebrates, and little is known about differences in the regulation of translation in the two systems. Herein, we identify a threonyl-tRNA synthetase (TRS)-mediated translation initiation machinery that specifically interacts with eIF4E homologous protein, and forms machinery that is structurally analogous to the eIF4F-mediated translation initiation machinery via the recruitment of other translation initiation components. Biochemical and RNA immunoprecipitation analyses coupled to sequencing suggest that this machinery emerged as a gain-of-function event in the vertebrate lineage, and it positively regulates the translation of mRNAs required for vertebrate development. Collectively, our findings demonstrate that TRS evolved to regulate vertebrate translation initiation via its dual role as a scaffold for the assembly of initiation components and as a selector of target mRNAs. This work highlights the functional significance of aminoacyl-tRNA synthetases in the emergence and control of higher order organisms.