bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kallikrein-related peptidases and associated microRNAs as promising prognostic biomarkers in gastrointestinal malignancies
Authors: Adamopoulos Panagiotis G. , Tsiakanikas Panagiotis , Scorilas Andreas 
Published: July 2018

Abstract
Gastrointestinal (GI) malignancies represent a wide spectrum of diseases of the GI tract and its accessory digestive organs, including esophageal (EC), gastric (GC), hepatocellular, pancreatic (PC) and colorectal cancers (CRC). Malignancies of the GI system are responsible for nearly 30% of cancer-related morbidity and approximately 40% of cancer-related mortality, worldwide. For this reason, the discovery of novel prognostic biomarkers that can efficiently provide a better prognosis, risk assessment and prediction of treatment response is an imperative need. Human kallikrein-related peptidases (KLKs) are a subgroup of trypsin and chymotrypsin-like serine peptidases that have emerged as promising prognosticators for many human types of cancer, being aberrantly expressed in cancerous tissues. The aberrant expression of KLKs in human malignancies is often regulated by KLK/microRNAs (miRNAs) interactions, as many miRNAs have been found to target KLKs and therefore alter their expression levels. The biomarker utility of KLKs has been elucidated not only in endocrine-related human malignancies, including those of the prostate and breast, but also in GI malignancies. The main purpose of this review is to summarize the existing information regarding the prognostic significance of KLKs in major types of GI malignancies and highlight the regulatory role of miRNAs on the expression levels of KLKs in these types of cancer.
Designing a Holistic Behavior Change Support System for Healthy Aging
Authors: Herrmanny Katja , Schwarz Michael , Paldán Katrin , Beckmann Nils , Sell Jennifer , Wagner Nils-Frederic , Dogangün Aysegül 
Published: July 2018

Abstract
In this paper, we describe the development of a behavior change support system to improve health. The system is designed for people in the age range of 50–65 with an interdisciplinary approach. The basic structure of the presented system consists of two main modules: a monitoring module to collect and analyze data and an intervention module to support behavior changes. Based on the results of a requirements analysis and findings gathered from a conducted literature review and own analyses, the behavior change system addresses the following lifestyle areas: physical activity, nutrition, mental fitness, sleep, and nature contact. We outline how the concept is developed with regards to the results of the requirements analysis and psychological foundations to explain and predict motivation and behavior change processes. We describe how single system components match phases of behavior change models and how they were implemented into an Android application. Finally, we present the results of usability studies where the comprehensibility of the concept and application was tested together with the usability of navigation structure and design. The results show that the target group is able to understand the concept and can navigate through the system easily.
Development of an Inertial Motion Capture System for Clinical Application
Authors: Bleser Gabriele , Taetz Bertram , Miezal Markus , Christmann Corinna A. , Steffen Daniel , Regenspurger Katja 
Published: July 2018

Abstract
The ability to capture human motion based on wearable sensors has a wide range of applications, e.g., in healthcare, sports, well-being, and workflow analysis. This article focuses on the development of an online-capable system for accurately capturing joint kinematics based on inertial measurement units (IMUs) and its clinical application, with a focus on locomotion analysis for rehabilitation. The article approaches the topic from the technology and application perspectives and fuses both points of view. It presents, in a self-contained way, previous results from three studies as well as new results concerning the technological development of the system. It also correlates these with new results from qualitative expert interviews with medical practitioners and movement scientists. The interviews were conducted for the purpose of identifying relevant application scenarios and requirements for the technology used. As a result, the potentials of the system for the different identified application scenarios are discussed and necessary next steps are deduced from this analysis.
Sociotechnical Systems in the Textile Industry
Authors: Altepost Andrea , Löhrer Mario , Ziesen Nenja , Saggiomo Marco , Strüver Niklas , Houben Daniel , Gloy Yves-Simon 
Published: July 2018

Abstract
This article delineates the work of an interdisciplinary research group concerning the implementation of a digital assistance system in the German textile industry. Using a holistic approach, researchers from different disciplines contribute to the design of an integrated socio-technical method that guides industrial actors in developing and implementing digital assistance systems that are applicable on the shop-floor level and at the same time take into account various social and organizational demands. Following this approach, the development of new technologies is coordinated with innovative social practices, for example, learning techniques or organizational changes. Furthermore, aspired users of the assistance system participate in the project by contributing their expertise of the working progress as well as by defining requirements essential towards addressing the various challenges at hand. The conceptual outline and early findings of the project, including the development of a prototype of the assistance system, are presented in this article.
Dissolution Characteristics of Freeze-Dried Pullulan Particles Affected by Solution Concentration and Freezing Medium
Authors: Xu Qing , Yao Yan , Zhao Tong , Shi Qiongqiong , Li Zhanyong , Tian Wei 
Published: July 2018

Abstract
Pullulan particles were prepared to improve water solubility. The pullulan droplet with the concentration of 5%, 10%, 15% or 20% (w/w) was injected and frozen in the cryogenic media of liquid nitrogen at −196 °C or cold air at −15 °C, then freeze dried. The results show that most of dried pullulan particles pre-processed in either liquid nitrogen or cold air can be completely dissolved in water within 60 s. The water solubility of as-prepared particles in liquid nitrogen is better than that in cold air. The particles frozen at −196 °C have smaller and more uniform pore structures together with a larger specific surface area than those frozen at −15 °C. It is found that the particles from 10% pullulan solution with liquid nitrogen have largest water solubility and also highest specific surface area (11.78 m2/g).
The Impact of Information on Willingness to Pay and Quantity Choices for Meat and Meat Substitute
Authors: Castellari Elena , Marette Stéphan , Moro Daniele , Sckokai Paolo 
Published: July 2018

Abstract
We evaluate the impact of different types of information on participants' willingness-to-pay (WTP) and quantity choices for both beef and soy burger meat. To this end, we conducted a lab experiment to elicit WTP with multiple-price lists and chosen quantities of two products in a basket. Participants were provided with explanatory messages regarding the impact of beef and soy on health and environment before successive rounds of WTP determinations and quantity choices. Results show a weak impact of successive rounds of messages on WTP for both beef and soy, while leading to higher relative variations for chosen quantities. These relative changes in both WTP and quantities are then combined for computing the value of information. Results show a relatively low value of information compared to the expenditure for beef. In the last section of the paper we evaluate the effect of the introduction of a beef burger labeled “Fed without GMO” on WTP and quantity choices. Results underline a weak impact of “Fed without GMO” label on changing participants' preferences.
A Flame Detection Method Based on Novel Gradient Features
Authors: Liping Zhu , Hongqi Li , Fenghui Wang , Jie Lv , Ali Sikandar , Hong Zhang 
Published: July 2018

Abstract
In this study, we present a novel approach to efficiently detect the flame in multiple scenes in an image. The method uses a set of parametric representation named as Gradient Features (GF), to learn the features of flame color changes in the image. Different from the traditional color features of the flame, GF represents the color changes in RGB channels for further consideration. In this study, support vector machine was applied to generate a set of candidate regions and the decision tree model was used to judge flame regions based on GF. Some exclusive experiments were conducted to verify the validity and effectiveness of the proposed method. The results showed that the proposed method can accurately differentiate between yellow color light and sunrise scenes. A comparison with the state-of-the-art preceding methods showed that this method can utilize the symmetry of flame regions and achieve a better result.
Van Wyk-Grumbach syndrome with hemangioma in an infant
Authors: Biswas Moumita , Sinha Malay Kumar , Das Mrinal Kanti , Sarkar Sumantra 
Published: July 2018

Abstract

Background
Van Wyk-Grumbach syndrome (VWGS) is characterized by juvenile primary hypothyroidism, delayed bone age and isosexual incomplete precocious puberty with reversal to the prepubertal state following thyroid hormone replacement.

Case presentation
In this case, an 18-month-old girl presented with premature menarche since 9 months of age, delayed bone age and enlarged bilateral multicystic ovaries along with a superficial infantile hemangioma over the upper anterior chest. VWGS was diagnosed based on the clinical features. High serum thyroid stimulating hormone and low free thyroxine with the absence of any carpal bones in the wrist X-ray were suggestive of congenital hypothyroidism. Interestingly, the coexisting hemangioma could also play a role in the etiology of the hypothyroidism through “consumptive hypothyroidism”. Thyroid hormone replacement resulted in the complete resolution of signs and symptoms.

Conclusions
Untreated congenital hypothyroidism of short duration, onset of symptoms in infancy and association of an infantile hemangioma in VWGS were the unique features in our case.
What Proportion of Time is a Particular Market Inefficient? … A Method for Analysing the Frequency of Market Efficiency when Equity Prices Follow Threshold Autoregressions
Authors: Ahmed Muhammad Farid , Satchell Stephen 
Published: July 2018

Abstract
We assume that equity returns follow multi-state threshold autoregressions and generalize existing results for threshold autoregressive models presented in Knight and Satchell 2011. “Some new results for threshold AR(1) models,” Journal of Time Series Econometrics 3(2011):1–42 and Knight, Satchell, and Srivastava (2014) for the existence of a stationary process and the conditions necessary for the existence of a mean and a variance; we also present formulae for these moments. Using a simulation study, we explore what these results entail with respect to the impact they can have on tests for detecting bubbles or market efficiency. We find that bubbles are easier to detect in processes where a stationary distribution does not exist. Furthermore, we explore how threshold autoregressive models with i.i.d trigger variables may enable us to identify how often asset markets are inefficient. We find, unsurprisingly, that the fraction of time spent in an efficient state depends upon the full specification of the model; the notion of how efficient a market is, in this context at least, a model-dependent concept. However, our methodology allows us to compare efficiency across different asset markets.
A scatterer-assisted whispering-gallery-mode microprobe
Authors: Shu Fangjie , Jiang Xuefeng , Zhao Guangming , Yang Lan 
Published: July 2018

Abstract
A fiber-based whispering-gallery-mode (WGM) microprobe, combining both the high optical field enhancement of the WGMs and the compact structure of the optical fiber, is highly desired for sensing and imaging. Here we report a WGM microsphere resonator coupled to a single-mode fiber interfaced by a graded-index lens. By scattering a focused laser beam through a nano-scatterer, with the help of a two-step focusing technique as well as Purcell effects, the efficient far-field coupling of WGMs with an efficiency as high as 16.8% has been demonstrated in our system. With the feature of both input and output of the probe light propagating along the same fiber, such a scatterer-assisted WGM microprobe will serve as a convenient tool for sensing/imaging applications.
Crystal structure of 5-methylpyrazine-2-carbohydrazide, C6H8N4O
Authors: Gao Liang-Liang , Zhao Xiao-Lei , Wu Wei-Na 
Published: July 2018

Abstract
C6H8N4O, monoclinic, P21/c (no. 14), a = 8.019(5) Å, b = 9.990(6) Å, c = 9.050(6) Å, β = 98.474(10)°, V = 717.1(7) Å3, Z = 4, R
gt(F) = 0.0405, wR
ref(F
2) = 0.1205, T = 296(2) K.
The impact of zeolite filler on ageing and mechanical failure of paper
Authors: Engin Merve , Atik Celil 
Published: July 2018

AbstractThe choice of the filler type for paper materials has been a qualitative discussion. The mineral precipitated calcium carbonate (PCC) is used in considerable quantities in the pulp and paper industry as filler. However, alternative filler materials have been researched for improving the properties of paper. In this work, a domestic zeolite (clinoptilolite) filler was used separately and mixed with precipitated calcium carbonate (PCC) fillers. Indeed, the objective of our approach was to explore the structural and mechanical properties of handsheets having filler content affected as a function of accelerated ageing. The results confirmed that the mixed furnish of zeolite and PCC fillers provides positive and synergistic effect on the mechanical properties of ageing handsheets at the low content.
Selective laser melting of polymers: influence of powder coating on mechanical part properties
Authors: Drexler Maximilian , Greiner Sandra , Lexow Matthias , Lanzl Lydia , Wudy Katrin , Drummer Dietmar 
Published: July 2018

Abstract
For the derivation of part quality increasing process strategies, knowledge about interactions between sub-processes of selective laser melting (SLM) and resulting part properties is necessary. The SLM process consists of three major sub-processes: powder coating, exposure, and material consolidation. According to the interaction of sub-processes, resulting processing conditions during SLM determine the part properties by changing micro structural pore number and distribution. In addition to absolute temperatures, the time-dependency of the thermal fields also influences the porosity of molten parts. Present process strategies tend to decrease building time by acceleration of the subprocesses. Apart from prior investigated acceleration of the exposure, the powder coating step is focused. Within the paper, the authors analyze the basic interactions between different coating parameters and part properties. The authors estimate an interaction between coating speed and resulting part properties due to a force impact caused by the moved coating mechanism. Therefore, specimens produced with different coating speeds are analyzed with imaging technologies as well as mechanical tests. Based on the investigations, new processing strategies can be established considering the forces applied to the powder bed during the coating process, as well as the unique compaction behavior of current and future used powders.
National Memory and Divisive Narrative Building in Poland’s 2010 Presidential Election
Authors: Lupion Miranda 
Published: July 2018

AbstractThis paper employs the 2010 Polish presidential election as a case study to explore the implications of memory politics, examining the Law and Justice party’s (PiS) use of national memory ahead of the June election. Through process tracing, this paper finds that the Smolensk Air Crash became the central theme of this race, which pitted Civic Platform (PO) candidate Bronisław Komorowski against the late President Lech Kaczynski’s twin brother, PiS’s Jarosław Kaczynski. Amplified by the media, PiS selectively drew on easily recognisable events and figures from Polish history to construct an “Us versus Them” conflict of “true Polish patriots” - those who supported the party and its anti-Russian stance - and “Others” - those who, although sympathetic to the crash victims, favoured Tusk and his push for renewed Polish-Russian relations. The primary goal of this paper is to demonstrate how a historical memory approach can inform the study of contemporary politics - a subject which is too oft en left solely to social scientists.
Regulations Regarding the Spelling of National Minorities’ Names in the Documents and the Protection of the State Language in Latvia and Lithuania
Authors: Jędrysiak Marcin 
Published: July 2018

Abstract
The goal of this article is to compare the Latvian and Lithuanian provisions regarding the spelling of names of the members of the national minorities. Lithuanians often state an opinion, that provisions in both countries are very similar, and Latvian Poles cannot use the original form of their names. The legal comparative methods have been used. In the paper the most important provisions of both countries were analyzed: Constitution, state language law, law on the state language commission and the special regulations on the spelling of the names. Also, the problems with the national minorities law were analyzed. This comparison led to the discovery of differences in the Lithuanian and Latvian provisions regarding the spelling of names. Another factor which had been taken into account is the standing of the international bodies on those regulations. It has been presented by showing most important cases regarding Latvia and Lithuania. Above mentioned means allowed the author to verify the thesis that Latvian and Lithuanian provisions are similar. Both legal systems have also been criticized.
Prevalence of Prolonged QTC Interval in Patients Taking Psychopharmacs
Authors: Jovanovic Zoran , Radonjic Vesela , Jelic Ratomir , Petrovic-Subic Narcisa , Soldatovic Ivan , Terzic Vera , Stojilkovic Sladjan , Djuric Dusan 
Published: July 2018

Abstract
Apart from providing knowledge on the beneficial effects of drugs, practical psychopharmacotherapy also includes drug profiles of adverse effects, especially when medical comorbidity is present. The mechanism of action of many psychotropic drugs, mainly antipsychotics and antidepressants, is associated with prolongation of the QT interval and the occurrence of arrhythmias, specifically Torsade de pointes (TdP), which can be lethal. The aim of this pilot study was to confirm the prevalence of prolonged QTc interval in a sample of psychiatric patients taking psychopharmacs.
The present study included 41 patients who were already on psychopharmacs. The average value of the QTc interval in the observed sample was 413.8±23.3 ms. The most frequent psychopharmacotherapy was the combination of typical and atypical antipsychotics (24.4%), followed by monotherapy with antipsychotics (22%) and combined antidepressant and atypical antipsychotic therapy (22%). The average value of the QTc interval for male patients was 412.1±25.2 ms, whereas for female patients, it was 416.6±20.4 ms. No difference between sexes was confirmed (p=0.555). The correlation between the QTc interval and age of patients was positive but not statistically significant (p=0.072). The highest average (419.3±31.6 ms) and highest maximum (479 ms) values of the QTc interval were noted for patients undergoing combined therapy of antidepressants and atypical antipsychotics. Prolonged values of the QTc interval were observed for seven males and one female, and no patients exhibited pathological values.
This study confirmed previous research that found that prolongation of the QTc interval exists in patients in sample groups who take psychopharm acs, but not up to critical values.
Montenegro. Capitalist Transformation at the European Periphery
Authors: Lazić Mladen 
Published: July 2018

Abstract
The author reviews the basic facts necessary to understand the specific process of Montenegro’s capitalist transformation in the past thirty years or so, a process particularly influenced by certain characteristics of the political system. The survival in power of one political party throughout the period of systemic changes, as well as the more than twenty-year personal rule of Milo Đukanović which continued despite the introduction of liberal-pluralist principles, are primarily explained by the control of the state apparatus by the ruling elite. Alongside that was a low level of economic development. In addition, ambivalent attitudes of the populace to Montenegro’s independence from Serbia and the interethnic relations of Serbs and Montenegrins have played their own role. In the second part, the text displays the leitmotif underlying the contributions to the thematic section on Montenegro in this issue.
Effects of Eccentric Cycling Performed at Long vs. Short Muscle Lengths on Heart Rate, Rate Perceived Effort, and Muscle Damage Markers
Authors: Peñailillo Luis , Aedo Carolina , Cartagena Mayari , Contreras Alejandra , Reyes Alvaro , Ramirez-Campillo Rodrigo , Earp Jacob E. , Zbinden-Foncea Hermann 
Published: July 2018

Abstract
Peñailillo, L, Aedo, C, Cartagena, M, Contreras, A, Reyes, A, Ramirez-Campillo, R, Earp, JE, and Zbinden-Foncea, H. Effects of eccentric cycling performed at long vs. short muscle lengths on heart rate, rate perceived effort, and muscle damage markers. J Strength Cond Res 34(10): 2895–2902, 2020—It is possible that the magnitude of muscle damage in eccentric cycling is dependent on seat position that could affect the muscle length changes during eccentric contractions. However, no previous study has investigated the effect of seat position on muscle damage and metabolic demand in eccentric exercise. Thus, this study compared 2 seating positions; seat forward in which knee extensor muscles were stretched longer (LONG) and seat back in which the muscles were stretched shorter (SHORT). Young men performed 30 minutes of eccentric cycling at 80% of maximal concentric power output at either LONG (n = 10) or SHORT (n = 10) condition. Heart rate and rate perceived effort (RPE) during exercise, changes in maximal voluntary isometric contraction (MVC) strength of the knee extensors, muscle soreness assessed by a visual analog scale (VAS), and pressure-pain threshold (PPT) before, immediately after, and 24–72 hours after exercise were compared between conditions. Heart rate and RPE were significantly greater in LONG than SHORT group (9.5 and 19.0%, respectively). Post-exercise reduction in MVC was 8.4–14.0% greater in LONG than SHORT group from immediately after to 48 hours after exercise. In addition, VAS was greater in LONG than SHORT group from 48 to 72 hours after exercise, and vastus medialis PPT was greater in SHORT than LONG group from 24 to 72 hours after exercise (p < 0.05). These results suggest that muscle damage and metabolic demand are greater when seat is set back than forward. Thus, when prescribing eccentric cycling to individuals who are unaccustomed to eccentric cycling, it is better to set the seat far from the pedals.