bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negotiating Female Authorship in Eighteenth-Century India: Gender and Multilingualism in a Persian Text
Authors: SHAH ZAHRA 
Published: June 2019

AbstractIn the last years of the eighteenth century, an Indian woman authored a work in Persian intended for the entertainment and guidance of students of that language. EntitledMiftāḥ-i Qulūb-i Mubtadiyān(‘The Key of the Hearts of Beginners’), the work comprised of stories from vernacular oral traditions as well as extracts from well-known Persian poetic, historical and ethical works. Although the work was translated into English in 1908 by Annette Beveridge, it has received no serious scholarly attention. Drawing upon recent scholarship offering new ways of thinking about India's multilingual literary past, this article examines the intersection of multiple vernacular and generic traditions as translated and manifested inMiftāḥ-i Qulūb al-Mubtadīyān. While vernacular languages followed different, and in relative terms, more limited routes of circulation and exchange in comparison with cosmopolitan languages such as Persian, their paths of movement were no less significant. Through a close reading of this work and its context, this article seeks to understand how Bībī Ḥashmat al-Daula crafted a distinct, cosmopolitan voice for herself through her deployment of both Persianate and regional Indian traditions.
Characterizing the Image Forming Particles of Modern Ungilded Daguerreotypes Using XRD and SEM
Authors: Ravines Patrick , Nazarenko Alexander Y. 
Published: June 2019

AbstractX-ray diffraction (XRD) and high-resolution scanning electron microscopy (SEM) have been used to characterize the silver mercury amalgam particles resting on the surface that comprise the image of five daguerreotype plates that were not gilded and that were prepared by three different contemporary daguerreotype makers. The regions of interest of the surface that were examined were overexposed, solarized, and highlight (white) areas. The XRD portion of the study shows that the two main silver mercury amalgam particles identified using the International Center for Diffraction Data PF4 + database were the Schachnerite/ζ (zeta) phase amalgam, Ag1.1Hg0.9, and the mercury silver amalgam, Ag0.65Hg0.35. On one of the daguerreotypes a third silver mercury amalgam, Moschellandsbergite, Ag2Hg3, was also identified in small concentrations. High-resolution SEM images corroborate the diffraction data and show that the crystalline nature of the silver mercury amalgam particles on all five plates to be mostly hexagonal, which would correspond to the Schachnerite/ζ (zeta) phase amalgam, and fewer rectangular solid and cubic crystals corresponding to the mercury silver amalgam.
Dosimetric comparison between intensity-modulated radiotherapy and volumetric-modulated arc therapy in hippocampus sparing in brain metastasis treated by whole-brain irradiation and simultaneous integrated boost
Authors: Saad Ehab , Elshahat Khaled , Metwally Hussein 
Published: June 2019

AbstractBackground:While treating brain metastasis with whole-brain radiotherapy incorporating a simultaneous integrated boost (WBRT-SIB), the risk of hippocampus injury is high. The aim of this study is to compare dosimetrically between intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) in sparing of hippocampus and organs at risk (OARs) and planning target volume (PTV) coverage.Methods:In total, 16 patients presenting with more than one brain metastases were previously treated and then retrospectively planned using VMAT and IMRT techniques. For each patient, a dual-arc VMAT and another IMRT (five beams) plans were created. For both techniques, 30 Gy in 10 fractions was prescribed to the whole brain (WB) minus the hippocampi and 45 Gy in 10 fractions to the tumour with 0·5 cm margin. Dose–volume histogram (DVH), conformity index (CI) and homogeneity index (HI) of PTV, hippocampus mean and maximum dose and other OARs for both techniques were calculated and compared.Results:A statistically significant advantage was found in WB-PTV CI and HI with VMAT, compared to IMRT. There were lower hippocampus mean and maximum doses in VMAT than IMRT. The maximum hippocampus dose ranged between 15·5 and 19·2 Gy and between 18·4 and 20·6 Gy in VMAT and IMRT, respectively. The mean dose of the hippocampus ranged between 11·5 and 17·7 Gy and between 13·2 and 18·3 Gy in VMAT and IMRT, respectively.Conclusion:Using WBRT-SIB technique, VMAT showed better PTV coverage with less mean and maximum doses to the hippocampus than IMRT. Clinical randomised studies are needed to confirm safety and clinical benefit of WBRT-SIB.
THE DYNAMICAL MORDELL–LANG CONJECTURE FOR ENDOMORPHISMS OF SEMIABELIAN VARIETIES DEFINED OVER FIELDS OF POSITIVE CHARACTERISTIC
Authors: Corvaja Pietro , Ghioca Dragos , Scanlon Thomas , Zannier Umberto 
Published: June 2019

AbstractLet $K$ be an algebraically closed field of prime characteristic $p$, let $X$ be a semiabelian variety defined over a finite subfield of $K$, let $\unicode[STIX]{x1D6F7}:X\longrightarrow X$ be a regular self-map defined over $K$, let $V\subset X$ be a subvariety defined over $K$, and let $\unicode[STIX]{x1D6FC}\in X(K)$. The dynamical Mordell–Lang conjecture in characteristic $p$ predicts that the set $S=\{n\in \mathbb{N}:\unicode[STIX]{x1D6F7}^{n}(\unicode[STIX]{x1D6FC})\in V\}$ is a union of finitely many arithmetic progressions, along with finitely many $p$-sets, which are sets of the form $\{\sum _{i=1}^{m}c_{i}p^{k_{i}n_{i}}:n_{i}\in \mathbb{N}\}$ for some $m\in \mathbb{N}$, some rational numbers $c_{i}$ and some non-negative integers $k_{i}$. We prove that this conjecture is equivalent with some difficult diophantine problem in characteristic 0. In the case $X$ is an algebraic torus, we can prove the conjecture in two cases: either when $\dim (V)\leqslant 2$, or when no iterate of $\unicode[STIX]{x1D6F7}$ is a group endomorphism which induces the action of a power of the Frobenius on a positive dimensional algebraic subgroup of $X$. We end by proving that Vojta’s conjecture implies the dynamical Mordell–Lang conjecture for tori with no restriction.
Localization of unknown electromagnetic source using 3D-antenna arrays
Authors: Pala Sreenivasulu , Palliyani Srividhya , Himdi Mohamed , Lafond Olivier , Kurup Dhanesh G. 
Published: June 2019

AbstractIn this article, we propose three-dimensional antenna systems for determining the position of electromagnetic radiation source at an unknown location. Received signal power at different antennas and position of radiation source are used as training data for Artificial Neural Network (ANN). It is found that, a well-trained ANN is computationally efficient and capable of predicting the unknown location of the source, from the received power pattern. Two multi-antenna systems with geometry in three dimensions, namely the cube and frustum, are considered in this paper. Further, test results of the proposed method for random positions of electromagnetic source, spanning a hemisphere, are presented for the geometries considered.
MESSENGER Observations of Disappearing Dayside Magnetosphere Events at Mercury
Authors: Slavin J. A. , Middleton H. R. , Raines J. M. , Jia Xianzhe , Zhong J. , Sun W.‐J. , Livi S. , Imber S. M. , Poh G.‐K. , Akhavan‐Tafti M. , Jasinski J. M. , DiBraccio G. A. , Dong C. , Dewey R. M. , Mays M. L. 
Published: June 2019

AbstractMErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) measurements taken during passes over Mercury's dayside hemisphere indicate that on four occasions the spacecraft remained in the magnetosheath even though it reached altitudes below 300 km. During these disappearing dayside magnetosphere (DDM) events, the spacecraft did not encounter the magnetopause until it was at very high magnetic latitudes, ~66 to 80°. These DDM events stand out with respect to their extremely high solar wind dynamic pressures, Psw ~140 to 290 nPa, and intense southward magnetic fields, Bz ~ −100 to −400 nT, measured in the magnetosheath. In addition, the bow shock was observed very close to the surface during these events with a subsolar altitude of ~1,200 km. It is suggested that DDM events, which are closely associated with coronal mass ejections, are due to solar wind compression and/or reconnection‐driven erosion of the dayside magnetosphere. The very low altitude of the bow shock during these events strongly suggests that the solar wind impacts much of Mercury's sunlit hemisphere during these events. More study of these disappearing dayside events is required, but it is likely that solar wind sputtering of neutrals from the surface into the exosphere maximizes during these intervals.
The potential of sedimentary ancient DNA for reconstructing past sea ice evolution
Authors: De Schepper Stijn , Ray Jessica L , Skaar Katrine Sandnes , Sadatzki Henrik , Ijaz Umer Z , Stein Ruediger , Larsen Aud 
Published: June 2019

Abstract
Sea ice is a crucial component of the Arctic climate system, yet the tools to document the evolution of sea ice conditions on historical and geological time scales are few and have limitations. Such records are essential for documenting and understanding the natural variations in Arctic sea ice extent. Here we explore sedimentary ancient DNA (aDNA), as a novel tool that unlocks and exploits the genetic (eukaryote) biodiversity preserved in marine sediments specifically for past sea ice reconstructions. Although use of sedimentary aDNA in paleoceanographic and paleoclimatic studies is still in its infancy, we use here metabarcoding and single-species quantitative DNA detection methods to document the sea ice conditions in a Greenland Sea marine sediment core. Metabarcoding has allowed identifying biodiversity changes in the geological record back to almost ~100,000 years ago that were related to changing sea ice conditions. Detailed bioinformatic analyses on the metabarcoding data revealed several sea-ice-associated taxa, most of which previously unknown from the fossil record. Finally, we quantitatively traced one known sea ice dinoflagellate in the sediment core. We show that aDNA can be recovered from deep-ocean sediments with generally oxic bottom waters and that past sea ice conditions can be documented beyond instrumental time scales. Our results corroborate sea ice reconstructions made by traditional tools, and thus demonstrate the potential of sedimentary aDNA, focusing primarily on microbial eukaryotes, as a new tool to better understand sea ice evolution in the climate system.
Mitochondrial miR-762 regulates apoptosis and myocardial infarction by impairing ND2
Authors: Yan Kaowen , An Tao , Zhai Mei , Huang Yan , Wang Qi , Wang Yunhong , Zhang Rongcheng , Wang Tao , Liu Jing , Zhang Yuhui , Zhang Jian , Wang Kun 
Published: June 2019

AbstractMitochondrial dysfunction plays a major role in the pathogenesis of cardiovascular diseases. MicroRNAs (miRNAs) are small RNAs that act as negative regulators of gene expression, but how miRNAs affect mitochondrial function in the heart is unclear. Using a miRNA microarray assay, we found that miR-762 predominantly translocated in the mitochondria and was significantly upregulated upon anoxia/reoxygenation (A/R) treatment. Knockdown of endogenous miR-762 significantly attenuated the decrease in intracellular ATP levels, the increase in ROS levels, the decrease in mitochondrial complex I enzyme activity and the increase in apoptotic cell death in cardiomyocytes, which was induced by A/R treatment. In addition, knockdown of miR-762 ameliorated myocardial ischemia/reperfusion (I/R) injury in mice. Mechanistically, we showed that enforced expression of miR-762 dramatically decreased the protein levels of endogenous NADH dehydrogenase subunit 2 (ND2) but had no effect on the transcript levels of ND2. The luciferase reporter assay showed that miR-762 bound to the coding sequence of ND2. In addition, knockdown of endogenous ND2 significantly decreased intracellular ATP levels, increased ROS levels, reduced mitochondrial complex I enzyme activity and increased apoptotic cell death in cardiomyocytes, which was induced by A/R treatment. Furthermore, we found that the inhibitory effect of miR-762 downregulation was attenuated by ND2 knockdown. Thus, our findings suggest that miR-762 participates in the regulation of mitochondrial function and cardiomyocyte apoptosis by ND2, a core assembly subunit of mitochondrial complex I. Our results revealed that mitochondrial miR-762, as a new player in mitochondrial dysfunction, may provide a new therapeutic target for myocardial infarction.
Alteration of the IL-33-sST2 pathway in hypertensive patients and a mouse model
Authors: Yin Xiaoyun , Cao Huajun , Wei Yingjie , Li Hui-Hua 
Published: June 2019

AbstractInflammatory cells play an important role in the occurrence of hypertension. Recent studies have demonstrated that interleukin-33/suppression of tumorigenicity 2 (IL-33/ST2) signaling plays a critical role in the pathogenesis of several cardiovascular diseases. We aimed to evaluate the association of IL-33 and its receptor levels with the occurrence of hypertension in angiotensin II (Ang II)-infused mice using microarray analysis and validated our results in human specimens. Male wild-type mice were infused with Ang II (1500 ng/kg/min) for 1, 3 and 7 days. Patients with essential hypertension (EH) (n = 166) and healthy control subjects (n = 306) were enrolled. Levels of IL-33 and ST2 mRNAs in serum and peripheral blood mononuclear cells (PBMCs) were analyzed by Luminex assay or ELISA and qPCR analysis. We found that IL-33 expression was significantly increased in the aortas of mice receiving Ang II infusion compared with that of control mice. In contrast, the levels of IL-33 in serum and PBMCs were not significantly different between hypertensive patients and normal controls. However, the levels of soluble ST2 (sST2) in serum and PBMCs were markedly higher in hypertensive patients than in controls (P < 0.001 and P = 0.014, respectively). In addition, the ST2L level in PBMCs was also significantly decreased in hypertensive patients (P = 0.028). Further, logistic analysis showed that the odds ratios of having hypertension based on sST2 levels in serum and PBMCs were 9.714 and 2.244 (P = 0.013 and P = 0.024, respectively) compared with the control group. Above all, sST2 acted as a risk factor for the occurrence of hypertension and may be a promising novel predictive marker for EH.
Role of network-mediated stochasticity in mammalian drug resistance
Authors: Farquhar Kevin S. , Charlebois Daniel A. , Szenk Mariola , Cohen Joseph , Nevozhay Dmitry , Balázsi Gábor 
Published: June 2019

AbstractA major challenge in biology is that genetically identical cells in the same environment can display gene expression stochasticity (noise), which contributes to bet-hedging, drug tolerance, and cell-fate switching. The magnitude and timescales of stochastic fluctuations can depend on the gene regulatory network. Currently, it is unclear how gene expression noise of specific networks impacts the evolution of drug resistance in mammalian cells. Answering this question requires adjusting network noise independently from mean expression. Here, we develop positive and negative feedback-based synthetic gene circuits to decouple noise from the mean for Puromycin resistance gene expression in Chinese Hamster Ovary cells. In low Puromycin concentrations, the high-noise, positive-feedback network delays long-term adaptation, whereas it facilitates adaptation under high Puromycin concentration. Accordingly, the low-noise, negative-feedback circuit can maintain resistance by acquiring mutations while the positive-feedback circuit remains mutation-free and regains drug sensitivity. These findings may have profound implications for chemotherapeutic inefficiency and cancer relapse.
Probing the active fraction of soil microbiomes using BONCAT-FACS
Authors: Couradeau Estelle , Sasse Joelle , Goudeau Danielle , Nath Nandita , Hazen Terry C. , Bowen Ben P. , Chakraborty Romy , Malmstrom Rex R. , Northen Trent R. 
Published: June 2019

AbstractThe ability to link soil microbial diversity to soil processes requires technologies that differentiate active microbes from extracellular DNA and dormant cells. Here, we use BONCAT (bioorthogonal non-canonical amino acid tagging) to measure translationally active cells in soils. We compare the active population of two soil depths from Oak Ridge (Tennessee, USA) and find that a maximum of 25–70% of the extractable cells are active. Analysis of 16S rRNA sequences from BONCAT-positive cells recovered by fluorescence-activated cell sorting (FACS) reveals that the phylogenetic composition of the active fraction is distinct from the total population of extractable cells. Some members of the community are found to be active at both depths independently of their abundance rank, suggesting that the incubation conditions favor the activity of similar organisms. We conclude that BONCAT-FACS is effective for interrogating the active fraction of soil microbiomes in situ and provides a new approach for uncovering the links between soil processes and specific microbial groups.
Neuronal representation of environmental boundaries in egocentric coordinates
Authors: Hinman James R. , Chapman G. William , Hasselmo Michael E. 
Published: June 2019

AbstractMovement through space is a fundamental behavior for all animals. Cognitive maps of environments are encoded in the hippocampal formation in an allocentric reference frame, but motor movements that comprise physical navigation are represented within an egocentric reference frame. Allocentric navigational plans must be converted to an egocentric reference frame prior to implementation as overt behavior. Here we describe an egocentric spatial representation of environmental boundaries in the dorsomedial striatum.
Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression
Authors: An Tian , Fan Tao , Zhang Xin Qing , Liu Yu-Fei , Huang Jiangpinghao , Liang Cong , Lv Bo-Han , Wang Yin-Qian , Zhao Xin-Gang , Liu Jia-Xian , Fu Yu- Huan , Jiang Guang-Jian 
Published: June 2019

AbstractAbnormal expression of microRNAs (miRNAs) contributes to glioma initiation. However, the expression of miRNAs in tumour tissue or blood of spinal cord glioma (SCG) patients, particularly in high-grade spinal gliomas (Grade IV) known as glioblastoma (GBM), remains largely unknown. In this study we aimed to determine differentially expressed miRNAs (DEmiRNAs) in the tissue and blood between spinal cord glioblastoma (SC-GBM) patients and low grade SCG (L-SCG) patients. Additionally, we predicted key miRNA targets and pathways that may be critical in glioma development using pathway and gene ontology analysis. A total of 74 miRNAs were determined to be differentially expressed (25 upregulated and 49 downregulated) in blood, while 207 miRNAs (20 up-regulated and 187 down-regulated) were identified in tissue samples. Gene ontology analysis revealed multicellular organism development and positive regulation of macromolecule metabolic process to be primarily involved. Pathway analysis revealed “Glioma”, “Signalling pathways regulating pluripotency of stem cells” to be the most relevant pathways. miRNA-mRNA analysis revealed that hsa-miRNA3196, hsa-miR-27a-3p, and hsa-miR-3664-3p and their target genes are involved in cancer progression. Our study provides a molecular basis for SCG pathological grading based on differential miRNA expression.
Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels
Authors: Markiewicz Anna , Brożyna Anna A. , Podgórska Ewa , Elas Martyna , Urbańska Krystyna , Jetten Anton M. , Slominski Andrzej T. , Jóźwicki Wojciech , Orłowska-Heitzman Jolanta , Dyduch Grzegorz , Romanowska-Dixon Bożena 
Published: June 2019

AbstractIn recent years, a significant number of studies have investigated the preventive role of vitamin D in a number of different neoplasms. In this study, we analyze various components of the vitamin D signaling pathways in the human uveal tract and uveal melanoma, including analysis of the expression of vitamin D receptors (VDR), the activating and inactivating hydroxylases, respectively, CYP27B1 and CYP24A1, and the retinoic acid-related orphan receptors (ROR) α (RORα) and γ (RORγ) in these tissues. We further analyzed the expression of VDR, CYP27B1, CYP24A1, and ROR in relation to melanin levels, clinical stage and prognosis. Our study indicated that the uveal melanoma melanin level inversely correlated with VDR expression. We further showed that vitamin D is metabolized in uveal melanoma. This is significant because until now there has been no paper published, that would describe presence of VDR, hydroxylases CYP27B1 and CYP24A1, and RORα and RORγ in the human uveal tract and uveal melanomas. The outcomes of our research can contribute to the development of new diagnostic and therapeutic methods in uveal tract disorders, especially in uveal melanoma. The presented associations between vitamin D signaling elements and uveal melanoma in comparison to uveal tract encourage future clinical research with larger patients’ population.
Proving hydrogen addition mechanism from manure to coal surface obtained by GC-MS and 1H-NMR analysis
Authors: Koyunoğlu Cemil , Karaca Hüseyin 
Published: June 2019

AbstractIn this study, to explain the possibility of hydrogen transfer paths from manure to coal, Elbistan lignite (EL) combined with manure liquefaction of oil + gas products were analysed with Gas Chromatography-Mass Spectroscopy (GC-MS) and Nuclear Magnetic Resonance Spectroscopy (1H-NMR) technique. In the same way, it is observed that oils which as they fragment to an alkane-alkene mixture, serve as a hydrogen “sponge” and put a serious hydrogen need on the parts of the free radicals and molecules that are currently hydrogen poor. Concerning Elbistan lignite and manure do not have any aromatic hydrogen. Moreover, when the aromatic compounds were hydrogenated, their aromatic hydrogen was transformed to naphthenic hydrogen. Hydrogen transfer was due to isomerization of heptane from 3-methylhexane obtained in test oil where only manure was present as hydrogen donor in the liquefaction environment despite hydrogenation of isomerization from naphthalene to azulene.
Optical properties and pulse shape discrimination in siloxane-based scintillation detectors
Authors: Marchi T. , Pino F. , Fontana C. L. , Quaranta A. , Zanazzi E. , Vesco M. , Cinausero M. , Daldosso N. , Paterlini V. , Gramegna F. , Moretto S. , Collazuol G. , Degerlier M. , Fabris D. , Carturan S. M. 
Published: June 2019

AbstractThe possibility to detect fast neutrons as a distinct signal from that one of γ-rays background is surely of great importance for several topics, spanning from homeland security to radiation monitoring in nuclear physics research plants. Nowadays, Helium-3 based detectors are extremely expensive, while the use of large volume liquid scintillators presents serious concerns related to spillage risks and waste disposal. A very attractive alternative is the use of commercially available solid scintillators, which exploits an aromatic polymer matrix entrapping very high loadings of primary dye, thereby enabling the use of pulse shape analysis (PSA) to discriminate between fast neutrons and γ-rays. In this work, we analyse in detail the optical features of a solid scintillator composed by polymethylphenylsiloxane (PMPS) as base polymer loaded with moderate amounts of 2,5-diphenyloxazole (PPO). Furthermore, fluorescence decay kinetics have been correlated to the observed pulse shape discrimination capabilities of this radiation and thermally resistant scintillator, whose performances have been discussed in terms of conformational features and excimers formation revealed by the optical analyses.