bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing psychotherapy dosage for comorbid depression and personality disorders (PsyDos): a pragmatic randomized factorial trial using schema therapy and short-term psychodynamic psychotherapy
Authors: Kool Marit , Van Henricus L. , Bartak Anna , de Maat Saskia C. M. , Arntz Arnoud , van den Eshof Johanna W. , Peen Jaap , Blankers Matthijs , Bosmans Judith E. , Dekker Jack J. M. 
Published: August 2018

Abstract
Background
Patients with comorbid depression and personality disorders suffer from a heavy disease burden while tailored treatment options are limited, accounting for a high psychological and economic burden. Little is known about the effect of treatment dosage and type of psychotherapy for this specific co-morbid patient population, in terms of treatment-effect and cost-effectiveness. This study aims to compare treatment outcome of 25 versus 50 individual therapy sessions in a year. We expect the 50-session condition to be more effective in treating depression and maintaining the effect. Secondary objectives will be addressed in order to find therapy-specific and non-specific mechanisms of change.

Methods
In a mono-center pragmatic randomized controlled trial with a 2 × 2 factorial design, 200 patients with a depressive disorder and personality disorder(s) will be included. Patients will be recruited from a Dutch mental health care institute for personality disorders. They will be randomized over therapy dosage (25 vs 50 sessions in a year) and type of therapy (schema therapy vs short-term psychodynamic supportive psychotherapy). The primary clinical outcome measure will be depression severity and remission. Changes in personality functioning and quality of life will be investigated as secondary outcomes. A priori postulated effect moderators and mediators will be collected as well. All patients are assessed at baseline and at 1, 2, 3, 6, 9–12 months (end of therapy) and at follow up (6 and 12 months after end of treatment). Alongside the trial, an economic evaluation will be conducted. Costs will be collected from a societal perspective.

Discussion
This trial will be the first to compare two psychotherapy dosages in patients with both depression and personality disorders. Insight in the effect of treatment dosage for this patient group will contribute to both higher treatment effectiveness and lower costs. In addition, this study will contribute to the limited evidence base on treating patients with both depression and personality disorders. Understanding the processes that account for the therapeutic changes could help to gain insight in what works for whom.

Trial registration
This trial has been registered on July 20th 2016, Netherlands Trial Register, part of the Dutch Cochrane Centre (NTR5941).
The Assessment of Negative and Positive Features in Schizophrenia
Authors: Johnstone Eve C. 
Published: August 2018

It has become customary to classify the typical abnormalities of the mental state of schizophrenic patients into positive and negative features, with reference to behavioural excesses and deficits. Positive features are pathological by their presence and negative features represent the loss of some normal function. Positive features are generally considered to include delusions, hallucinations and positive formal thought disorder (Fish, 1962). Some studies (e.g. Johnstone et al, 1978) have also included incongruity of affect under this heading. Negative features include affective flattening, poverty of speech, retardation, apathy, lack of sociability. There is some evidence that the clinical correlates of positive and negative features may not be the same (Owens & Johnstone, 1980). Some workers (Andreasen & Olsen, 1982) but not others (Pogue-Geile & Harrow, 1984) have found that among schizophrenic patients positive and negative symptoms were negatively correlated. Although the nature of the relationship between positive and negative features is not entirely established and may not be simple (Wing, 1978) certain generalisations may be applied:
(a)Positive features are characteristic of earlier and negative of later phases of the illness (Pfohl & Winokur, 1982).(b)The effects of drugs upon positive features are greater than those upon negative features. Thus neuroleptics produce more marked improvement (Johnstone et al, 1978; Angrist et al, 1980) and amphetamine more marked exacerbation (Angrist et al, 1980) of positive than of negative features.(c)Positive features have been said to be relatively variable and negative features relatively stable (Ovchinnikov, 1968; Snezhnevsky, 1968).
Evaluating the Transfer of Care from Psychiatric Hospitals to District-Based Services
Authors: Leff Julian 
Published: August 2018

In July 1983 the Regional Medical Officer of the North East Thames Regional Health Authority (NETRHA) appeared on television to announce the closure of Claybury Hospital and much of Friern Hospital over a ten-year period.When NETRHA announced its decision, the policy to be pursued was innovative because it involved psychiatric hospitals serving inner-city populations, and because there was apparently no intention to achieve its aim by decanting patients into other psychiatric hospitals, as had been done with the closures of St Wulstan's and Banstead Hospitals. Although the run-down of psychiatric hospitals had been occurring at a steady rate in the United States and in England and Wales since the early 1950s, there had been few attempts to evaluate the policy, and none had been in any sense comprehensive (this supplement, paper 7). Clinicians and research workers in the field of social psychiatry were well aware of the need for large-scale evaluative studies, since protagonists and opponents of the policy of deinstitutionalisation were locked in a polemical argument which was pursued with increasing stridency through lack of reliable information.
Early detection and intervention of schizophrenia: rationale and research
Authors: McGlashan Thomas H. 
Published: August 2018

Background The primary rationale for early detection and intervention in schizophrenia is the disorder's severity, chronicity and treatment resistance. This suggests that researchers pay closer attention to schizophrenia's premorbid and onset phases, when the vulnerability to psychosis becomes expressed and the neurobiological deficit processes driving symptom formation appear to be the most active.Method We review the evidence that brain plasticity may be retained or reversed despite deficit processes.Results The data are preliminary but suggestive enough to warrant further research.Conclusions Overall, we need to focus on the early course of schizophrenia, detecting cases early at onset or in the prodrome, testing whether this enhances treatment response and prognosis, and predicting at-risk cases early in the prodromal phase. Designs to address these questions are presented, and relevant issues are discussed.
Understanding the topography of the early psychosis pathways
Authors: Lincoln Clare , Harrigan Susy , McGorry Pat D. 
Published: August 2018

Background This study aims to gain an understanding of treatment delays and their nature in initial psychotic episodes. We investigated to whom people turn for help, how long that approach takes and subsequent delays in commencing treatment.Method Qualitative and quantitative methods were combined with interviews of 62 people suffering from first-episode psychoses, aged 16–30 years, who had recently accessed a specialist mental health service in Melbourne, Australia. A modified version of the World Health Organization Encounter Form was analysed in conjunction with other data.ResultsPathways to care and the ways in which they were experienced were highly variable, with 50% of people experiencing psychotic symptoms before approaching any service. The general practitioner played a key role with 50% of people having had GP contact at some point prior to commencing effective treatment. Where an individual's own efforts to seek early help failed, the role of relatives and others was subsequently vital.Conclusions Opportunities exist for shortening delays through targeted health promotion activities and professional training. The need is indicated for a multi-layered or topographical strategy to identify and minimise critical barriers on the route to early intervention. Refinement of interview techniques and instruments of measurement are needed to enhance the explanatory power of data collected.
Effect of substance misuse in early psychosis
Authors: Addington Jean , Addington Donald 
Published: August 2018

BackgroundStudies examining the temporal relationship between substance use and the onset of psychotic symptoms in schizophrenia are inconclusive.MethodThree groups of out-patients with schizophrenia were compared on onset of illness, symptoms and quality of life. Fifty-one subjects had no past or present history of substance misuse, 29 subjects had a history of past substance misuse occurring around the onset of their illness, and 33 subjects were currently misusing substances.ResultsCurrent substance misusers had poorer quality of life scores and less negative symptoms than the non-users. Those who had a past history of substance misuse had a significantly earlier age of onset than those with no substance use.ConclusionsAttention should be paid to substance misuse present at the first episode. Treatment for schizophrenia should begin even though a diagnosis of drug-induced psychosis cannot be ruled out.
1H NMR Determination of Incorporated Porphyrin Location in Lipid Membranes of Liposomes
Authors: Nakaya Toshimi , Tsuchiya Yuki , Horiguchi Banri , Sugikawa Kouta , Komaguchi Kenji , Ikeda Atsushi 
Published: August 2018

Abstract
Lipid-membrane-incorporated symmetrical and unsymmetrical porphyrins were prepared with relatively high concentrations via exchange from cyclodextrins to liposomes. We determined the location of these porphyrins in the lipid membranes from chemical shift changes of the lipid signals in the 1H NMR spectra. Symmetrical tetraphenyl porphyrin accumulates in the hydrophobic core of the lipid membranes. In contrast, several unsymmetrical porphyrins with more polar group(s), such as pyridine and pyridinium moieties, are located close to the liposome surface.
Maçonaria e Educação - Poucos mas bons
Authors: Arriada Eduardo , Tambara Elomar 
Published: August 2018

Esta investigação teve como escopo analisar a relação entre instituição maçônica brasileira e educação. Caracterizou-se o processo de elitização que distingue aquela organização social. Tal processo significou a congregação de um grupo extremamente qualificado tanto em termos acadêmicos como financeiros. Quanto à educação verificou-se que esta foi uma preocupação sempre presente na pauta das diversas lojas maçônicas. Apesar desta priorização observou-se que, a despeito de algumas iniciativas pioneiras neste sentido, os resultados, como um todo, foram relativamente acanhados.Palavras chaves: Educação e Maçonaria; História da Educação; Instituições Educacionais.Abstract This investigation has the purpose of analyzing the relationship between the Brazilian freemasonry institution and education. The process of elitism which distinguishes this social organization is characterized. Such a process meant the association of an extremely qualified group, both in academic and financial terms. Regarding education it was verified that this has always been a present concern in the many freemasonry stores’ agendas. Despite this prioritization, it was observed that regardless of some pioneer initiatives in that sense the results as a whole were relatively timid.Key words: Education and Freemasonry; History of Education; Educational Institutions. ResumenEsta investigación tiene como objetivo analizar la relación entre la institución masónica de Brasil y la educación. En ella se presentan las características del proceso de elitización que distingue a esta institución social. Éste proceso significó la congregación de un grupo extremadamente calificado de personas tanto a nivel académico como financiero. En relación a la educación, se constató que esta fue una preocupación siempre presente en las prioridades de las diversas logias masónicas, pero pesar de este criterio y del desarrollo de algunas iniciativas pioneras, los resultados fueron relativamente bajos.Palabras clave: Educación y Masonería, Historia de la Educación, Instituciones Educativas.
On the maximum conjecture
Authors: Sabzevari Masoud 
Published: August 2018

AbstractWe verify the maximum conjecture on the rigidity of totally nondegenerate model CR manifolds in the following two cases: (i) for all models of CR dimension one, (ii) for the so-called full-models, namely those in which their associated symbol algebras are free CR. In particular, we discover that in each arbitrary CR dimension and length≥3{\geq 3}, there exists at least one totally nondegenerate model, enjoying this conjecture. Our proofs rely upon some recent results in the Tanaka theory of transitive prolongation of fundamental algebras.
Homogeneous Finsler spaces and the flag-wise positively curved condition
Authors: Xu Ming , Deng Shaoqiang 
Published: August 2018

Abstract
In this paper, we introduce the flag-wise positively curved condition for Finsler spaces (the (FP) condition), which means that in each tangent plane, there exists a flag pole in this plane such that the corresponding flag has positive flag curvature. Applying the Killing navigation technique, we find a list of compact coset
spaces admitting non-negatively curved homogeneous Finsler metrics
satisfying the (FP) condition. Using a crucial technique we developed previously, we prove that most of these coset spaces cannot be endowed with positively curved homogeneous Finsler metrics. We also prove that any
Lie group whose Lie algebra is a rank 2 non-Abelian compact Lie algebra
admits a left invariant Finsler metric satisfying the (FP) condition.
As by-products, we find
the first example of non-compact coset space

S
3

×
ℝ

{S^{3}\times\mathbb{R}}

which admits homogeneous flag-wise positively curved Finsler metrics.
Moreover, we find some non-negatively curved Finsler metrics
on

S
2

×

S
3

{S^{2}\times S^{3}}

and

S
6

×

S
7

{S^{6}\times S^{7}}

which satisfy the (FP) condition, as well as some flag-wise positively curved Finsler metrics on

S
3

×

S
3

{S^{3}\times S^{3}}

, shedding some light on the long standing general Hopf conjecture.
Relationship between various maternal conditions and lactic acid dehydrogenase activity in umbilical cord blood at birth
Authors: Patavoukas Evangelos , Åberg-Liesaho Josefina , Halvorsen Cecilia Pegelow , Winbladh Birger , Wiberg-Itzel Eva 
Published: August 2018

AbstractBackground:Lactic acid dehydrogenase (LDH) is a valuable marker for some of the most important diseases in newborns and the plasma LDH activity in newborns correlates well with conditions such as asphyxia. If LDH should be considered as a useful tool also in obstetric care, key factors associated with maternal health before and during pregnancy which could affect umbilical cord LDH activity need to be known. The aims of this study were to explore relationships between selected maternal conditions and arterial lactic acid dehydrogenase activity (aLDH) in umbilical cord blood at delivery.Methods:A prospective observational study was conducted at Sodersjukhuset, Stockholm, Sweden. Included in the study were 1247 deliveries, and cord blood samples from each were analyzed for aLDH. Background, delivery and neonatal data were collected from the medical records.Results:Higher median values of aLDH were found (P=0.001) among women with chronic disorders not related to pregnancy but there was no increased frequency of high aLDH levels (>612 μ/L, P=0.30). No difference in aLDH was identified between infants born to women with pregnancy-related disorders compared with healthy women, neither in median values, nor in high values (>612 μ/L, P=0.95).Conclusion:Newborn infants born to women with non-pregnancy-related chronic disorders had a somewhat higher median value of aLDH in cord blood at delivery. The influence of common maternal conditions and diseases on umbilical cord arterial LDH levels is small compared to the increase reported in fetal distress and several other critical conditions in the newborn.
Domination in 4-regular Knödel graphs
Authors: Mojdeh Doost Ali , Musawi S.R. , Nazari E. 
Published: August 2018

Abstract
A subset D of vertices of a graph G is a dominating set if for each u ∈ V(G) ∖ D, u is adjacent to some vertex v ∈ D. The domination number, γ(G) of G, is the minimum cardinality of a dominating set of G. For an even integer n ≥ 2 and 1 ≤ Δ ≤ ⌊log2
n⌋, a Knödel graph W

Δ, n
is a Δ-regular bipartite graph of even order n, with vertices (i, j), for i = 1, 2 and 0 ≤ j ≤ n/2 − 1, where for every j, 0 ≤ j ≤ n/2 − 1, there is an edge between vertex (1, j) and every vertex (2, (j+2
k
− 1) mod (n/2)), for k = 0, 1, ⋯, Δ − 1. In this paper, we determine the domination number in 4-regular Knödel graphs W
4,n
.
Algebras of right ample semigroups
Authors: Guo Junying , Guo Xiaojiang 
Published: August 2018

AbstractStrict RA semigroups are common generalizations of ample semigroups and inverse semigroups. The aim of this paper is to study algebras of strict RA semigroups. It is proved that any algebra of strict RA semigroups with finite idempotents has a generalized matrix representation whose degree is equal to the number of non-zero regular 𝓓-classes. In particular, it is proved that any algebra of finite right ample semigroups has a generalized upper triangular matrix representation whose degree is equal to the number of non-zero regular 𝓓-classes. As its application, we determine when an algebra of strict RA semigroups (right ample monoids) is semiprimitive. Moreover, we prove that an algebra of strict RA semigroups (right ample monoids) is left self-injective iff it is right self-injective, iff it is Frobenius, and iff the semigroup is a finite inverse semigroup.
The Riemann hypothesis and universality of the Riemann zeta-function
Authors: Garunkštis Ramūnas , Laurinčikas Antanas 
Published: August 2018

Abstract
We prove that, under the Riemann hypothesis, a wide class of analytic functions can be approximated by shifts ζ(s + iγk
), k ∈ ℕ, of the Riemann zeta-function, where γk
are imaginary parts of nontrivial zeros of ζ(s).
Structural, Optoelectronic and Thermoelectric Properties of Ternary CaBe2X2 (X = N, P, As, Sb, Bi) Compounds
Authors: Khan Abdul Ahad , Rehman Aziz Ur , Laref A. , Yousaf Masood , Murtaza G. 
Published: August 2018

Abstract
The structural, electronic, optical and thermoelectric properties of ternary CaBe2X2 (X = N, P, As, Sb and Bi) have been investigated comprehensively for the first time using density functional theory. All the compounds are optimized to obtain their ground states. Computed structural parameters agree to the available experimental results. Electronic band structure calculations reveal the semiconducting nature of the compounds, while bang gap decreases by changing the anion X from N to Bi the band gap decreases. In the valence band, major contribution is due to X-p state, while in conduction band (CB) the major contribution is mainly due to the Ca-d state. Furthermore, electron charge density plots reveal ionic bonding character with small covalent bonding. Optical properties are calculated in detail. Static value of refractive index shows inverse variation with band gap. The refractive indices of these compounds are high in the infrared region and gradually decreased in the visible and ultraviolet region. The thermoelectric properties are studied using Boltzmann statistics through BoltzTraP code. High optical conductivity peaks and figure of merits (ZT) for compounds reveal that they are good candidates for the optoelectronics and thermo-electric devices.
ISIL İŞLEM VE OLGUNLAŞTIRMA SÜRELERİNİN EZİNE PEYNİRİNDE BİYOJEN AMİN OLUŞUMUNA ETKİLERİ
Authors: DİLER Mehmet , AKBAĞ Erhan , IŞIK Volkan , AVŞAR GÜNAY Emine , ERKAYACAN Hakan , GÜNEŞER Onur , KARAGÜL YÜCEER Yonca 
Published: August 2018

Bu çalışmanın amacı farklı ısıl işlem sürelerinin Ezine peynirinde biyojen amin oluşumu ve mikroorganizma profilindeki değişimlerin olgunlaştırma süresince araştırılmasıdır. Çiğ süte 65oC’de 10 ve 30 dakika ısıl işlem uygulanarak Ezine peyniri üretilmiştir. Histamin, putresin, kadaverin, tiramin, triptamin ve feniletilamin biyojen aminleri yüksek basınçlı sıvı kromatografisi kullanılarak saptanmıştır. Peynir örneklerinde toplam psikrofilik ve mezofilik aerobik bakteriler, laktik asit bakterileri, fekal koliform, toplam maya-küf, Enterobacteriaceae spp. Escherichia coli ve Clostridium perfiringens sayıları da tespit edilmiştir. Taze peynirlerde biyojen amin oluşmamış olup peynir örneklerinde olgunlaşma süresince biyojen amin miktarı artmıştır. Ezine peynirinde saptanan biyojenik amin miktarlarının sağlık riski oluşturacak düzeylerde olmadığı görülmüştür. Ezine peynirinde farklı ısıl işlem sürelerinin toplam mezofilik aerobik bakteri ve laktik asit bakterisi üzerine etkisi depolama süresine bağlı olarak değişim göstermiştir.﻿
СТРУКТУРА ТА ТРАНСФОРМАЦІЇ ГАЗОННОГО ВКРИТТЯ МІСЬКИХ ПАРКІВ КАРПАТСЬКОГО РЕГІОНУ УКРАЇНИ
Authors: Henyk Ya.V. , Marutyak S.B. , Dyda A.P. 
Published: August 2018

Представлено результати дослідження систематичної та фітоценотичної структури газонів паркових насаджень міст Карпатського регіону України. Встановлено частоту трапляння окремих видів у газонному вкритті паркових екосистем урбанізованих територій. Здійснено кількісний розподіл природних і синантропних видів у чотирьох типах газонів паркових насаджень – партерних, звичайних садово-паркових, лучних та спортивних. Визначено частку участі традиційних та інвазійних видів у формуванні різних типів газонів міських парків Карпатського регіону України. Наведено трансформації газонного вкриття міських парків внаслідок недостатньої та неефективної парково-господарської діяльності та рекреаційних навантажень.
ВНУТРІШНЬОВИДОВЕ РІЗНОМАНІТТЯ ACER PLATANOIDES L. В ОЗЕЛЕНЕННІ КИЄВА ТА БОТАНІЧНИХ УСТАНОВАХ УКРАЇНИ
Authors: Man'ko M.V. 
Published: August 2018

Наведено результати інвентаризації насаджень загального користування та спеціального призначення Києва на наявність рослин A. platanoides L. та його культиварів. Виконано розподіл за віковими групами та оцінено загальний стан рослин. З'ясовано, що в озелененні Києва трапляються рослини 5 культиварів. За результатами аналізу внутрішньовидового різноманіття клена гостролистого у ботанічних установах України виявлено, що найбагатші колекції нараховують 8-9 культиварів. Загальна кількість культиварів A. platanoides, що представлена у ботанічних установах країни, становить 14 одиниць.