bluuebunny/crossref_metadata_2025_split huggingface dataset:
Total Lifestyle Coaching: A Pilot Study Evaluating the Effectiveness of a Mind–Body and Nutrition Telephone Coaching Program for Obese Adults at a Community Health Center
Authors: Chad-Friedman Emma , Pearsall Melanie , Miller Kathleen M , Wheeler Amy E , Denninger John W , Mehta Darshan H , Dossett Michelle L 
Published: July 2018

Background Stress and obesity are interrelated and common among low-income adults. Mind–body interventions have been shown to reduce psychological distress and have been incorporated into many weight loss interventions. However, few of these programs have incorporated a telephone coaching component. Objective We designed and piloted a novel weight loss telephone coaching intervention for this population and examined its effectiveness on weight loss and improvements in health behaviors in obese community health center patients. Methods This was a 6-month, single-arm, prospective, pre–post pilot study. The study took place at a community health center near Boston, Massachusetts. Participants were 27 overweight and obese community health center patients. The intervention consisted of one in-person intake with the registered dietitian, trained in mind–body approaches, and approximately 1 phone coaching session every 2 weeks for 6 consecutive months. Anthropometric data consisted of weight, body mass index (BMI), and blood pressure. Questionnaires consisted of the Perceived Stress Scale-10 item, the CIGNA Healthy Eating Survey, Section H: Behavioral Eating, a physical activity questionnaire, and a nutritional habits questionnaire. We used paired samples t tests to assess pre–post changes in weight, BMI, blood pressure, perceived stress, behavioral eating, and physical activity. We also conducted semistructured exit interviews to learn about participants’ experiences in this program. Results There was a trend toward weight reduction ( P < .1, Cohen’s d = 0.33) and significant improvements in systolic blood pressure ( P = .001, Cohen’s d = 0.72), perceived stress ( P = .001, Cohen’s d = 0.75), and behavioral eating ( P = .009, Cohen’s d = 0.54). Improvements in weight were sustained 6 months after completion of the intervention. Conclusion Results suggest that a telephone nutrition health coaching intervention is feasible and may facilitate weight loss in obese community health center patients. Future randomized-controlled studies are warranted to better understand these improvements. Clinicaltrials.gov registration NCT03025217
Midterm results of the cylindrical fully porous-coated uncemented femoral stem in revision patients with Paprosky I–IIIA femoral defects
Authors: Ahmet Salduz , İsmet Kılıçoğlu Önder , Mehmet Ekinci , Eren Yıldız , Remzi Tözün , Önder Yazıcıoğlu 
Published: July 2018

Introduction: The aim of this study was to analyze the survival of the Echelon® femoral stems in revision hip surgeries in patients with Paprosky I–IIIA femoral defects. Patients and methods: Sixty-six patients (70 hips) who underwent revision hip surgery with at least 3 years of follow-up data were included in the study between 2000 and 2013. The mean patient age was 64.5 (32–83) years, and the mean follow-up period was 93 (45–206) months. The reasons for revision were aseptic loosening in 55 (78.6%) patients, periprosthetic joint infection in 9 (12.9%) patients, periprosthetic fracture in 4 (5.7%) patients, and stem fracture in 2 (2.9%) patients. The preoperative and postoperative follow-up X-rays and functional scores were evaluated. Results: Five patients died in an average of 70 (45–86) months after surgery due to non-related diseases. We encountered sciatic nerve palsy in two patients and early hip dislocation in two patients, whereas 54 patients were able to walk without any assistive device. The remaining 12 patients required an assistive device to walk. The mean Harris hip score significantly increased from 34 (7–63) preoperatively to 72 (43–96) postoperatively. Aseptic loosening was observed in one patient. The survival of the porous-coated anatomical uncemented femoral stem was 98.4% over 10 years. Conclusion: This study showed that good clinical outcomes and survival can be obtained when using porous-coated anatomical uncemented femoral stems.
Pampaloite, AuSbTe, a new mineral from Pampalo gold mine, Finland
Authors: Vymazalová Anna , Kojonen Kari , Laufek František , Johanson Bo , Stanley Chris J. , Plášil Jakub , Halodová Patricie 
Published: July 2018

AbstractPampaloite, AuSbTe, is a new mineral discovered in the Pampalo gold mine, 65 km east of Joensuu, Finland. It forms anhedral grains (up to ~20 μm) intergrown with gold, frohbergite and altaite. Pampaloite is brittle and has a metallic lustre. Values of VHN25lie between 245 and 295 kg/mm2, with a mean value of 276 kg/mm2, corresponding to a Mohs hardness of ~4–5 (measured on synthetic material). In plane-polarised light, pampaloite is white with medium to strong bireflectance, weak reflectance pleochroism from slightly pinkish brown to slightly bluish white (only visible in grains of synthetic material containing multiple orientations), and strong anisotropy, with blue to light brown rotation tints; it exhibits no internal reflections. Reflectance values of pampaloite in air (R1,R2in %) are: 60.0, 62.5 at 470 nm, 62.5, 64.8 at 546 nm, 63.2, 65.6 at 589 nm and 63.7, 66.0 at 650 nm. Ten electron-microprobe analyses of natural pampaloite give an average composition: Au 44.13, Sb 27.44 and Te 28.74, total 100.31 wt.%, corresponding to the empirical formula Au1.00Sb1.00Te1.00based on 3 atoms; the average of eleven analyses on synthetic pampaloite is: Au 44.03, Sb 27.26, and Te 29.08, total 100.38 wt.%, corresponding to Au0.99Sb1.00Te1.01. The density, calculated on the basis of the empirical formula, is 9.33 g/cm3.The mineral is monoclinic, space groupC2/c, witha= 11.947(3),b= 4.481(1) Å,c= 12.335(3) Å, β = 105.83(2)°,V= 635.3(3) Å3andZ= 8. The crystal structure was solved and refined from the single-crystal X-ray-diffraction data of synthetic AuSbTe. The pampaloite crystal structure can be considered as a monoclinic derivative of the CdI2structure composed of [AuTe3Sb3] octahedra. The strongest lines in the powder X-ray diffraction pattern of synthetic pampaloite [din Å (I) (hkl)] are: 4.846(24)($\bar{2}$02), 3.825(18)(111), 2.978(100)($\bar{3}$11), 2.968(50)(004), 2.242(25)(020), 2.144(55)(313), 2.063(33)($\bar{3}$15) and 1.789(18)(024).
Crystal chemistry of K-rich nepheline in nephelinite from Hamada, Shimane Prefecture, Japan
Authors: Hamada Maki , Akasaka Masahide , Ohfuji Hiroaki 
Published: July 2018

AbstractK-rich nepheline with a structural formula of A2B6T14T24T34T44O32 (Z = 1) within melilite–olivine nephelinite from Hamada, Shimane Prefecture, Japan, was investigated to clarify its crystal structure and to determine cation distributions in the A and B structural positions of structural channels and tetrahedral T1–T4 sites. The chemical formula of a single-crystal sample was (Na5.437K2.248Mg0.034Ca0.031)Σ7.750(Si8.332Al7.445Fe3+0.158Ti0.009Cr0.005)Σ15.949O32, which results in 65.2, 27.8, 2.1, 3.2 and 1.6 mol.% NaAlSiO4, KAlSiO4, NaFe3+SiO4, □Si2O4 and □0.5(Ca,Mg)0.5AlSiO4 end-member components, respectively, where □ is a vacancy. X-ray diffraction data of a single crystal with dimensions of 0.28 mm × 0.15 mm × 0.05 mm measured at 296 K indicate the space group P63. In the structural refinement, the R1 factor was reduced to 3.69% by taking twinning by merohedry into the refinement. The refinement accounted for 77.7% of the absolute structure and 22.3% of the a and b axes reversed absolute structure. The atomic populations determined in the A and B positions were 1.834 K + 0.166 □ and 5.705 Na + 0.198 K + 0.031 Ca + 0.034 Mg, respectively, implying the substitution of K for Na in the B position. The a and c dimensions are a = 10.0270(3) and c = 8.4027(3) Å. The average &lt;A–O&gt; and &lt;B–O&gt; distances are 3.009 and 2.65 Å, respectively. The substitution of K for Na in the B channel results in increased volume and bond-length distortion of the BO8 polyhedra, which then reduces distortion of the AO9 polyhedra. The average T–O distances indicate that the T1 and T4 sites are essentially filled with Al, whereas the T2 and T3 are filled with Si. Despite the deviation of the O1 oxygen from the triad axis and the combination of K+ ions and vacancies in the hexagonal channels, an incommensurate structure was not observed in the X-ray diffraction data or using the electron diffraction technique.
Minerals of the rhabdophane group and the alunite supergroup in microgranite: products of low-temperature alteration in a highly acidic environment from the Velence Hills, Hungary
Authors: Ondrejka Martin , Bačík Peter , Sobocký Tomáš , Uher Pavel , Škoda Radek , Mikuš Tomáš , Luptáková Jarmila , Konečný Patrik 
Published: July 2018

ABSTRACTAn assemblage of alunite-supergroup minerals (ASM), rhabdophane-group minerals (RGM), goethite and associated clay minerals occurs in Permian A-type porphyritic microgranite in the eastern part of the Velence Hills, Hungary. The secondary sulfates/phosphates include jarosite, Pb-rich jarosite and alunite, corkite, hinsdalite and rhabdophane-(Ce), -(La) and -(Nd). Detailed electron probe microanalysis and Raman spectroscopy reveal a wide miscibility among RGM end-members and show a rhabdophane–tristramite–brockite solid solution with extensive compositional variation. Moreover, ASM show heterogeneous composition and complex substitution mechanisms within the alunite, beudantite and plumbogummite groups. The formation of this rare mineral assemblage reveals extensive remobilization of rare-earth elements (REE), Th, U, P, S, Fe and Pb under supergene conditions. Compositional variations and substitution trends of the RGM investigated indicate that Th, U, Ca and Pb are incorporated into the rhabdophane structure by a (Ca, Pb)2+ + (Th, U)4+ ↔ 2REE3+ substitution mechanism. Consequently, we suggest the following end-member formulae for RGM containing divalent and tetravalent cations: (Ca0.5Th0.5)PO4·H2O for brockite, (Pb0.5Th0.5)PO4·H2O for grayite and (Ca0.5U0.5)PO4·2H2O for tristramite. The ASM and RGM originated from total leaching of the primary magmatic REE, Th, U and P minerals in the microgranite [most probably allanite-(Ce), fluorapatite and possibly also xenotime-(Y)], together with input of Pb and S in low-temperature, acid sulfate solutions, connected with an adjacent Palaeogene andesite–diorite intrusion and the accompanying hydrothermal sulfide mineralization.
Structural brain correlates of obstructive sleep apnoea in older adults at risk for dementia
Authors: Cross Nathan E. , Memarian Negar , Duffy Shantel L. , Paquola Casey , LaMonica Haley , D'Rozario Angela , Lewis Simon J.G. , Hickie Ian B. , Grunstein Ronald R. , Naismith Sharon L. 
Published: July 2018

This study aimed to investigate associations between obstructive sleep apnoea (OSA) and cortical thickness in older adults with subjective and objective cognitive difficulties, who are considered “at-risk” for dementia.83 middle-aged to older adults (51–88 years) underwent neuropsychological testing, polysomnography assessment of OSA and a structural magnetic resonance imaging brain scan. A principal components analysis was performed on OSA measures. Cortical thickness and subcortical volumes were compared to extracted components of “oxygen desaturation” and “sleep disturbance”.Oxygen desaturation was significantly related to reduced cortical thickness in the bilateral temporal lobes (left: r=−0.44, p<0.001; right: r=−0.39, p=0.003). Conversely, sleep disturbance was associated with increased thickness in the right postcentral gyrus (r=0.48, p<0.001), pericalcarine (r=0.50, p=0.005) and pars opercularis (r=0.46, p=0.009) and increased volume of the hippocampus and amygdala. Decreased thickness in the bilateral temporal regions was associated with reduced verbal encoding (r=0.28, p=0.010).Given the clinical significance of this sample in terms of dementia prevention, these changes in grey matter reveal how OSA might contribute to neurodegenerative processes in older adults.
Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma
Authors: Retseck Janet , Nasr Alexis , Lin Yan , Lin Huang , Mendiratta Prateek , Butterfield Lisa H. , Tarhini Ahmad A. 
Published: July 2018

AbstractBackgroundWe previously reported early on-treatment significant modulation in circulating regulatory T cell (Treg), myeloid derived suppressor cells (MDSC) and antigen-specific type I CD4+ and CD8+ T cells that correlated with clinical outcome in regionally advanced melanoma patients treated with neoadjuvant ipilimumab. Here, we investigated the long term immunologic impact of CTLA4 blockade.MethodsPatients were treated with ipilimumab given at 10 mg/kg IV every 3 weeks for 2 doses bracketing surgery. Blood specimens were collected at baseline and during treatment for up to 9 months. We tested immune responses at 3, 6, and 9 months utilizing multicolor flow cytometry. We compared frequencies of circulating Treg and MDSC on-study to baseline levels, as well as frequencies of CD4+ and CD8+ T cells specific to shared tumor-associated antigens (Gp-100, MART-1, NY-ESO-1).ResultsLevels of Treg significantly increased when measured at 6 weeks following ipilimumab but returned to baseline by 3 months, with no significant difference in Treg levels between relapsed and relapse-free groups at 3, 6 or 9 months. However, lower baseline levels of circulating Treg (CD4+CD25hi+CD39+) were significantly associated with better relapse free survival (RFS) (p = 0.04). Levels of circulating monocytic HLA-DR+/loCD14+ MDSC were lower at baseline in the relapse-free group and further decreased at 6 weeks, though the differences did not reach statistical significance including measurements at 3, 6 or 9 months. We detected evidence of type I (interferon-γ producing), activated (CD69+) CD4+ and CD8+ antigen-specific T cell immunity against cancer-testis (NY-ESO-1) as well as melanocytic lineage (MART-1, gp100) antigens in the absence of therapeutic vaccination. These responses were significantly boosted at 6 weeks and persisted at 3, 6 and 9 months following the initiation of ipilimumab.ConclusionsLower Treg levels at baseline are significantly associated with RFS and increased Treg frequency after CTLA4 blockade was only transient. Lower MDSC was also associated with RFS and MDSC levels were further decreased after ipilimumab. Tumor specific effector immune responses are boosted with CTLA4 blockade and tend to be durable.Trial registrationClinicalTrials.gov Identifier: NCT00972933
Comprehensive genetic characteristics of dystrophinopathies in China
Authors: Ma Peipei , Zhang Shu , Zhang Hao , Fang Siying , Dong Yuru , Zhang Yan , Hao Weiwei , Wu Shiwen , Zhao Yuying 
Published: July 2018

Abstract
Background
Dystrophinopathies are a set of severe and incurable X-linked neuromuscular disorders caused by mutations in the dystrophin gene (DMD). These mutations form a complex spectrum. A national registration network is essential not only to provide more information about the prevalence and natural history of the disease, but also to collect genetic data for analyzing the mutational spectrum. This information is extremely beneficial for basic scientific research, genetic diagnosis, trial planning, clinical care, and gene therapy.

Methods
We collected data from 1400 patients (1042 patients with confirmed unrelated Duchenne muscular dystrophy [DMD] or Becker muscular dystrophy [BMD]) registered in the Chinese Genetic Disease Registry from March 2012 to August 2017 and analyzed the genetic mutational characteristics of these patients.

Results
Large deletions were the most frequent type of mutation (72.2%), followed by nonsense mutations (11.9%), exon duplications (8.8%), small deletions (3.0%), splice-site mutations (2.1%), small insertions (1.3%), missense mutations (0.6%), and a combination mutation of a deletion and a duplication (0.1%). Exon 45–50 deletion was the most frequent deletion type, while exon 2 duplication was the most common duplication type. Two deletion hotspots were calculated—one located toward the central part (exon 45–52) of the gene and the other toward the 5’end (exon 8–26). We found no significant difference between hereditary and de novo mutations on deletion hotspots. Nonsense mutations accounted for 62.9% of all small mutations (197 patients).

Conclusion
We built a comprehensive national dystrophinopathy mutation database in China, which is essential for basic and clinical research in this field. The mutational spectrum and characteristics of this DMD/BMD group were largely consistent with those in previous international DMD/BMD studies, with some differences. Based on our results, about 12% of DMD/BMD patients with nonsense mutations may benefit from stop codon read-through therapy. Additionally, the top three targets for exon-skipping therapy are exon 51 (141, 13.5%), exon 53 (115, 11.0%), and exon 45 (84, 8.0%).
Discovery of new Toxoplasma gondii antigenic proteins using a high throughput protein microarray approach screening sera of murine model infected orally with oocysts and tissue cysts
Authors: Döşkaya Mert , Liang Li , Jain Aarti , Can Hüseyin , Gülçe İz Sultan , Felgner Philip Louis , Değirmenci Döşkaya Aysu , Davies David Huw , Gürüz Adnan Yüksel 
Published: July 2018

Abstract
Background
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes congenital toxoplasmosis, as well as other serious clinical presentations in immune compromised humans. The parasite has also been recently linked to behavioral diseases in humans and other mammalian hosts. New antigens are being evaluated to develop a diagnostic kit for the diagnosis of acute infection or a protective vaccine.

Methods
In this study, we have focused on the discovery of new antigenic proteins from T. gondii genomic data using a high throughput protein microarray screening. To date, microarrays containing > 2870 candidate exon products of T. gondii have been probed with sera collected from patients with toxoplasmosis. Here, the protein microarrays are probed with well-characterized serum samples from animal models administered orally with oocysts or tissue cysts. The aim was to discover the antigens that overlap in the mouse profile with human antibody profiles published previously. For this, a reactive antigen list of 240 antigens recognized by murine IgG and IgM was identified using pooled sera from orally infected mice.

Results
Analyses of screening data have identified plenty of antigens and showed strong immunogenicity in both mouse and human antibody profiles. Among them, ROP1, GRA2, GRA3, GRA4, GRA5, GRA6, GRA7, GRA8, GRA14, MIC1, MIC2 and MAG1 have shown strong immunogenicity and used as antigen in development of vaccines or serological diagnostic assays in previous studies.

Conclusion
In addition to the above findings, ROP6, MIC12, SRS29A and SRS13 have shown strong immunogenicity but have not been tested in development of a diagnostic assay or a vaccine model yet.
Φοιτητές στο φάσμα του αυτισμού: Εμπόδια, δυνατότητες και τρόποι στήριξης στην τριτοβάθμια εκπαίδευση
Authors: Σταμπολτζή Αγλαϊα , Καλούρη Ράνυ , Τσίτσου Ελισάβετ 
Published: July 2018

Η Διαταραχή Αυτιστικού Φάσματος (ΔΑΦ) αποτελεί μια νευρο-αναπτυξιακή διαταραχή που ακολουθεί το άτομο διαβίου. Η συχνότητά εμφάνισής της έχει αλλάξει ριζικά τις τελευταίες δεκαετίες. Στο φάσμα του αυτισμού υπάρχει ένας μεγάλος αριθμός μαθητών με «ιδιαίτερες ικανότητες», υψηλή λειτουργικότητα και καλές ακαδημαϊκές προοπτικές. Οι μαθητές αυτοί συνεχίζουν στην τριτοβάθμια εκπαίδευση αλλά χρειάζονται υποστήριξη και καθοδήγηση για να καταφέρουν να ολοκληρώσουν τις σπουδές τους. Σκοπός της παρούσας εργασίας είναι να παρουσιάσει τα βασικά χαρακτηριστικά των φοιτητών με ΔΑΦ, τις δυσκολίες και τα εμπόδια που συναντούν στο πανεπιστήμιο, αλλά και αποτελεσματικούς τρόπους στήριξής τους στην τριτοβάθμια εκπαίδευση. Η ανασκόπηση της βιβλιογραφίας έγινε μέσω των βιβλιογραφικών βάσεων ProQuest, Eric και Sage Journals, όπου με προκαθορισμένα κριτήρια εντοπίστηκαν άρθρα, επίσημες εκθέσεις (reports) και διδακτορικές διατριβές. Τα βασικά συμπεράσματα των ερευνών παρουσιάζουν ομοιότητες παρά τις διαφορετικές χώρες στις οποίες έχουν γίνει οι έρευνες. Ένα βασικό συμπέρασμα που αξίζει να σημειωθεί είναι πως ορισμένοι από τους παραδοσιακούς τρόπους στήριξης που χρησιμοποιούνται για τους φοιτητές με ειδικές εκπαιδευτικές ανάγκες δεν είναι κατάλληλοι για τους φοιτητές στο αυτιστικό φάσμα που έχουν ανάγκη περισσότερης εξατομικευμένης υποστήριξης. Συμπερασματικά, τα Συμβουλευτικά Κέντρα των πανεπιστημίων σε συνεργασία με άλλες υπάρχουσες δομές μπορούν να συμβάλουν ουσιαστικά στη μαθησιακή και ψυχολογική στήριξη των φοιτητών με ΔΑΦ. Τα πανεπιστήμια έχουν να ωφεληθούν από τις «ειδικές ικανότητες» των φοιτητών αυτών αλλά και να εμπλουτίσουν τη γνώση τους για τη «διαφορετικότητα».
Case Report: Synchronous primary malignancy including the breast and endometrium
Authors: Banimostafavi Elham Sadat , Tayebi Sepideh , Tayebi Maryam , Montazer Fatemeh 
Published: July 2018

Breast and endometrial cancer are the most common types of female cancers, but the incidence of both of these malignancies in a single patient is a rare event. Multiple primary malignancy has been increasingly reported over the past decade, and double primary cancer is considered as the most common type. In this study, we present a 53-year-old woman with synchronous primary malignancy of breast and endometrium. This patient had a history of breast and endometrial cancer in her family. Mammography and chest CT of the patient revealed a mass in the right breast and left supraclavicular region. However, the patient did not want to initiate treatment. Subsequently, the patient returned with a chief complaint of persistent abnormal vaginal bleeding. Abdominopelvic CT scan of the patient revealed a huge soft tissue mass in the pelvic cavity. She underwent hysterectomy, and pathology revealed endometrioid carcinoma, which had invaded the full thickness of uterine wall. Since this type of malignancy is rare and several risk factors are associated with it, it is worth being considered by clinicians when making decisions about screening or strategy for prevention.