bluuebunny/crossref_metadata_2025_split huggingface dataset:
7‐Amino‐2‐aryl/hetero‐aryl‐5‐oxo‐5,8‐dihydro[1,2,4]triazolo[1,5‐a]pyridine‐6‐carbonitriles: Synthesis and adenosine receptor binding studies
Authors: Shaik Khasim , Deb Pran Kishore , Mailavaram Raghu Prasad , Chandrasekaran Balakumar , Kachler Sonja , Klotz Karl‐Norbert , Jaber Abdul Muttaleb Yousef 
Published: April 2019

AbstractA series of novel 7‐amino‐5‐oxo‐2‐substituted‐aryl/hetero‐aryl‐5,8‐dihydro[1,2,4]triazolo[1,5‐a]pyridine‐6‐carbonitriles (4a–4t) was synthesized, characterized and evaluated for their binding affinity and selectivity towards hA1, hA2A, hA2B and hA3 adenosine receptors (ARs). Compound 4a with a phenyl ring at 2‐position of the triazolo moiety of the scaffold showed high affinity and selectivity for hA1 AR (Ki hA1 = 0.076 μM, hA2A = 25.6 μM and hA3 > 100 μM). Introduction of various electron donating and withdrawing groups at different positions of the phenyl ring resulted in drastic reduction in affinity and selectivity towards all the ARs, except compound 4b with a 4‐hydroxyphenyl group at 2‐position. Interestingly, the replacement of the phenyl ring with a smaller heterocyclic thiophene ring (π excessive system) resulted in further improvement of affinity for hA1 AR of compound 4t (Ki hA1 = 0.051 μM, hA2A = 9.01 μM and hA3 > 13.9 μM) while retaining the significant selectivity against all other AR subtypes similar to compound 4a. The encouraging results for compounds 4a and 4t indicate that substitution at 2‐position of the scaffold with π‐excessive systems other than thiophene may lead to even more potent and selective hA1 AR antagonists.
Sacral nerve modulation for faecal incontinence: influence of age on outcomes and complications. A multicentre study
Authors: Mege D. , Meurette G. , Brochard C. , Damon H. , Lambrescak E. , Faucheron J.‐L. , Wyart V. , Lehur P.‐A. , Sielezneff I. , Siproudhis L. , Mion F. , Etienney I. , Houivet E. , Bridoux V. , Leroi A.‐M. 
Published: April 2019

AbstractAimFaecal incontinence is frequent in the elderly. Little is currently known about the efficacy of sacral nerve modulation (SNM) in the elderly. The present study aimed to assess the impact of age on the outcome of SNM and on the surgical revision and explantation rates by comparing the results of a large data set of patients.MethodProspectively collected data from patients who underwent an implant procedure between January 2010 and December 2015 in seven French centres were retrospectively evaluated. In total, 352 patients [321 women; median age (range): 63 (24–86) years] were included. Clinically favourable and unfavourable outcomes, and surgical revision and explantation rates, were compared according to the age of the patients.ResultsA similar outcome was observed when comparing patients < 70 years and ≥ 70 years (a favourable outcome in 79.2% and 76.2%, respectively, P = 0.89). The probability of a successful treatment as a function of time was similar for the two age groups (< 70 years and ≥ 70 years, P = 0.54). The explantation and revision rates were not influenced by age (explantation rate: 17% in patients < 70 years vs 14% in patients ≥ 70 years, P = 0.89; and revision rate: 42% in patients < 70 years vs 40% in patients ≥ 70 years, P = 0.89). The probability of explantation as a function of time was similar for the two age groups (P = 0.82). The limitations of this study were its retrospective status, the rate of loss at follow‐up and different durations of patient follow‐up.ConclusionsOur results suggest that patients ≥ 70 years suffering from faecal incontinence benefit from SNM with a similar risk as a younger population.
Transnational policy migration, interdisciplinary policy transfer and decolonization: Tracing the patterns of research ethics regulation in Taiwan
Authors: 甘 Zhen‐Rong Gan 偵蓉 , 伊瑟利 Mark Israel 馬克· 
Published: April 2019

AbstractResearch ethics regulation in parts of the Global North has sometimes been initiated in the face of biomedical scandal. More recently, developing and recently developed countries have had additional reasons to regulate, doing so to attract international clinical trials and American research funding, publish in international journals, or to respond to broader social changes.In Taiwan, biomedical research ethics policy based on ‘principlism’ and committee‐based review were imported from the United States. Professionalisation of research ethics displaced other longer‐standing ways of conceiving ethics connected with Taiwanese cultural traditions. Subsequently, the model and its discursive practices were extended to other disciplines. Regulation was also shaped by decolonizing discourses associated with asserting Indigenous peoples’ rights.Locating research ethics regulation within the language and practices of public policy formation and transfer as well as decolonization, allows analysis to move beyond the self‐referential and attend to the social, economic and political context within which regulation operates.
Similar effectiveness of dapagliflozin and GLP‐1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospective study
Authors: Fadini Gian Paolo , Sciannameo Veronica , Franzetti Ivano , Bottigliengo Daniele , D'Angelo Paola , Vinci Carmela , Berchialla Paola , Arena Salvatore , Buzzetti Raffaella , Avogaro Angelo ,   for the DARWIN‐T2D network
Published: April 2019

AbstractAimsAccording to cardiovascular outcome trials, some sodium‐glucose contransporter‐2 inhibitors (SGLT2i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are recommended for secondary cardiovascular prevention in type 2 diabetes (T2D). In this real‐world study, we compared the simultaneous reductions in HbA1c, body weight and systolic blood pressure after initiation of dapagliflozin or GLP‐1RA as second or a more advanced line of therapy.Materials and methodsDARWIN‐T2D was a retrospective multi‐centre study conducted at diabetes specialist clinics in Italy that compared T2D patients who initiated dapagliflozin or GLP‐1RA (exenatide once weekly or liraglutide). Data were collected at baseline and at the first follow‐up visit after 3 to 12 months. The primary endpoint was the proportion of patients achieving a simultaneous reduction in HbA1c, body weight and systolic blood pressure. To reduce confounding, we used multivariable adjustment (MVA) or propensity score matching (PSM).ResultsTotals of 473 patients initiating dapagliflozin and 336 patients initiating GLP‐1RA were included. The two groups differed in age, diabetes duration, HbA1c, weight and concomitant medications. The median follow‐up was 6 months in both groups. Using MVA or PSM, the primary endpoint was observed in 30% to 32% of patients, with no difference between groups. Simultaneous reduction of HbA1c, BP and SBP by specific threshold, as well as achievement of final goals, did not differ between groups. GLP‐1RA reduced HbA1c by 0.3% more than the reduction achieved with dapagliflozin.ConclusionIn routine specialist care, initiation of dapagliflozin can be as effective as initiation of a GLP‐1RA for attainment of combined risk factor goals.
Comparing the effects of ipragliflozin versus metformin on visceral fat reduction and metabolic dysfunction in Japanese patients with type 2 diabetes treated with sitagliptin: A prospective, multicentre, open‐label, blinded‐endpoint, randomized controlled study (PRIME‐V study)
Authors: Koshizaka Masaya , Ishikawa Ko , Ishibashi Ryoichi , Maezawa Yoshiro , Sakamoto Kenichi , Uchida Daigaku , Nakamura Susumu , Yamaga Masaya , Yokoh Hidetaka , Kobayashi Akina , Onishi Shunichiro , Kobayashi Kazuki , Ogino Jun , Hashimoto Naotake , Tokuyama Hirotake , Shimada Fumio , Ohara Emi , Ishikawa Takahiro , Shoji Mayumi , Ide Shintaro , Ide Kana , Baba Yusuke , Hattori Akiko , Kitamoto Takumi , Horikoshi Takuro , Shimofusa Ryota , Takahashi Sho , Nagashima Kengo , Sato Yasunori , Takemoto Minoru , Newby Laura Kristin , Yokote Koutaro ,   On Behalf of the PRIME‐V Study Group
Published: April 2019

AbstractA prospective, multicentre, open‐label, blinded‐endpoint, randomized controlled study was conducted to evaluate the efficacy of treatment with ipragliflozin (sodium‐dependent glucose transporter‐2 inhibitor) versus metformin for visceral fat reduction and glycaemic control among Japanese patients with type 2 diabetes treated with sitagliptin, HbA1c levels of 7%‐10%, and body mass index (BMI) ≥ 22 kg/m2. Patients were randomly assigned (1:1) to receive ipragliflozin 50 mg or metformin 1000‐1500 mg daily. The primary outcome was change in visceral fat area as measured by computed tomography after 24 weeks of therapy. The secondary outcomes were effects on glucose metabolism and lipid metabolism. Mean percentage reduction in visceral fat area was significantly greater in the ipragliflozin group than in the metformin group (−12.06% vs. −3.65%, P = 0.040). Ipragliflozin also significantly reduced BMI, subcutaneous fat area, waist circumference, fasting insulin, and homeostatic model assessment (HOMA)‐resistance, and increased HDL‐cholesterol levels. Metformin significantly reduced HbA1c and LDL‐cholesterol levels and increased HOMA‐beta. There were no severe adverse events. The use of ipragliflozin or metformin in combination with dipeptidyl peptidase‐4 inhibitors, widely used in Japan, may have beneficial effects in ameliorating multiple cardiovascular risk factors.
Clinical spectrum, evolution, and management of autoimmune cytopenias associated with angioimmunoblastic T‐cell lymphoma
Authors: Crickx Etienne , Poullot Elsa , Moulis Guillaume , Goulabchand Radjiv , Fieschi Claire , Galicier Lionel , Meignin Véronique , Coppo Paul , Delarue Richard , Casasnovas Olivier , Roos‐Weil Damien , de Leval Laurence , Parrens Marie , Michel Marc , Dupuis Jehan , Le Bras Fabien , Fataccioli Virginie , Martin‐Garcia Nadine , Godeau Bertrand , Haïoun Corinne , Gaulard Philippe , Mahévas Matthieu 
Published: April 2019

AbstractObjectiveAngioimmunoblastic T‐cell lymphoma (AITL) is frequently associated with autoimmune cytopenia (AIC). Whether such patients have a particular phenotype and require particular management is unclear.MethodAngioimmunoblastic T‐cell lymphoma patients from the multicentric database of the Lymphoma Study Association presenting with AIC during disease course were included and matched to AITL patients without AIC (1/5 ratio).ResultsAt diagnosis, AIC patients (n = 28) had more spleen and bone marrow involvement (54% vs 19% and 71% vs 34%, P < 0.001), Epstein‐Barr virus replication (89% vs 39%, P < 0.001), gamma globulin titers (median 23 vs 15 g/L, P = 0.002), and proliferating B cells and plasmablasts in biopsies, as compared to control patients (n = 136). The 28 AIC patients had 41 episodes of AIC, diagnosed concomitantly with AITL in 23 (82%) cases. After a median follow‐up of 24 months (range 3‐155), 10 patients relapsed, all associated with AITL relapse.ConclusionOur results provide new insight into AIC associated with AITL by highlighting the significant interplay between AITL and B‐cell activation leading to subsequent autoimmunity.
Warming reduces the effects of enrichment on stability and functioning across levels of organisation in an aquatic microbial ecosystem
Authors: Tabi Andrea , Petchey Owen L. , Pennekamp Frank 
Published: April 2019

AbstractWarming and nutrient enrichment are major environmental factors shaping ecological dynamics. However, cross‐scale investigation of their combined effects by linking theory and experiments is lacking. We collected data from aquatic microbial ecosystems investigating the interactive effects of warming (constant and rising temperatures) and enrichment across levels of organisation and contrasted them with community models based on metabolic theory. We found high agreement between our observations and theoretical predictions: we observed in many cases the predicted antagonistic effects of high temperature and high enrichment across levels of organisation. Temporal stability of total biomass decreased with warming but did not differ across enrichment levels. Constant and rising temperature treatments with identical mean temperature did not show qualitative differences. Overall, we conclude that model and empirical results are in broad agreement due to robustness of the effects of temperature and enrichment, that the mitigating effects of temperature on effects of enrichment may be common, and that models based on metabolic theory provide qualitatively robust predictions of the combined ecological effects of enrichment and temperature.
Stepparents’ Attachment Orientation, Parental Gatekeeping, and Stepparents’ Affinity‐Seeking with Stepchildren
Authors: Ganong Lawrence , Jensen Todd , Sanner Caroline , Chapman Ashton , Coleman Marilyn 
Published: April 2019

Remarried stepfamilies are a sizable portion of American families; in a 2011 Pew Center survey, 42% of respondents reported at least one stepfamily member. Family clinicians and researchers suggest that stepparents’ ability to develop close bonds with stepchildren may be critical to the well‐being of couple and family relationships. Using actor‐partner interdependence models to analyze dyadic data from 291 heterosexual remarried stepfamily couples, we explored factors related to stepparents’ efforts to befriend their stepchildren. Specifically, we evaluated how remarried parents’ gatekeeping and stepparents’ perceptions of their attachment orientations were associated with their own and their spouse's perceptions of stepparents’ affinity‐seeking behaviors. Securely attached stepparents and stepparents with anxious attachment orientations engaged more frequently in affinity behaviors than did stepparents with avoidant attachment orientations; there was no difference between securely attached and anxious stepparents. Stepparents’ reports of parents’ restrictive gatekeeping were strongly and negatively associated with both stepparents’ and parents’ reports of stepparent affinity‐seeking (actor and partner effects). Parents’ reports of their own restrictive gatekeeping were also negatively (but more weakly) associated with parents’ reports of stepparent affinity‐seeking. Implications for families, clinicians, and relationship researchers and theorists are discussed.
Main features and applications of organogels in cosmetics
Authors: Martinez R. M. , Rosado C. , Velasco M. V. R. , Lannes S. C. S. , Baby A. R. 
Published: April 2019

AbstractCosmetic treatments aim at improving skin appearance through vehicles of good sensory properties. Those vehicles are mainly emulsions and gels designed to deliver safe and effective compounds to skin. Creams and serums are widely used to achieve these goals, but recently a new type of formulation known as organogels triggered scientific attention, particularly in the design of both topical and cosmetic formulations. It has been established that the lipophilic nature of organogels makes it an excellent candidate for the delivery of cosmetic molecules through skin. In this review, we discuss the properties and characteristics of organogels and present the advantages of the application of these systems in cosmetics.
Preferred Reporting Items for Animal Studies in Endodontology: a development protocol
Authors: Nagendrababu V. , Kishen A. , Murray P. E. , Nekoofar M. H. , de Figueiredo J. A. P. , Priya E. , Jayaraman J. , Pulikkotil S. J. , Dummer P. M. H. 
Published: April 2019

AbstractThe regulated use of animals in endodontic research is often necessary to investigate the biological mechanisms of endodontic diseases and to measure the preclinical efficacy, biocompatibility, toxicology and safety of new treatments, biomaterials, sealers, drugs, disinfectants, irrigants, devices and instruments. Animal testing is most crucial in situations when research on humans is not ethical, practical or has unknown health risks. Currently, there is a wide variability in the quality of manuscripts that report the results of animal studies. Towards the goal of improving the quality of publications, guidelines for preventing disability, pain, and suffering to animals, and enhanced reporting requirements for animal research have been developed. These guidelines are referred to as Animals in Research: Reporting In Vivo Experiments (ARRIVE). Henceforth, causing any form of animal suffering for research purposes is not acceptable and cannot be justified under any circumstances. The present report describes a protocol for the development of welfare and reporting guidelines for animal studies conducted in the specialty of Endodontology: the Preferred Reporting Items for Animal Studies in Endodontology (PRIASE) guidelines. The PRIASE guidelines will be developed by adapting and modifying the ARRIVE guidelines and the Clinical and Laboratory Images in Publication (CLIP) principles. The development of the new PRIASE guidelines will include a five‐step consensus process. An initial draft of the PRIASE guidelines will be developed by a steering committee. Each item in the draft guidelines will then be evaluated by members of a PRIASE Delphi Group (PDG) for its clarity using a dichotomous scale (yes or no) and suitability for its inclusion using a 9‐point Likert scale. The online surveys will continue until each item achieves this standard, and a set of items are agreed for further analysis by a PRIASE Face‐to‐face Consensus Meeting Group (PFCMG). Following the consensus meeting, the steering committee will finalize and confirm the PRIASE guidelines taking into account the responses and comments of the PFCMG. The PRIASE guidelines will be published and disseminated internationally and updated periodically based on feedback from stakeholders.
Innovative approaches to regulating decent work for domestic workers in Côte d'Ivoire: Labour administration and the judiciary under a general labour code
Authors: BLACKETT Adelle , KONÉ‐SILUÉ Assata 
Published: April 2019

AbstractThe authors offer a contextualized analysis of judicial decisions rendered during 1971–2013 in Côte d'Ivoire, where domestic work is regulated by a general labour code. Assessments of those decisions, alongside qualitative interviews of institutional actors, elucidate how innovative practices were mainly derived from the code by attentive inspectors and by jurisprudence evolving to treat domestic work like any other. Yet limitations emanating from the inability to grapple with the specificity of domestic work are also identified. Reaffirming that the regulation of domestic work must embrace its duality (work like any other and work like no other), the authors conclude with a call for an international community of learning on decent work for domestic workers.
Biostimulatory effects of polydioxanone, poly‐d, l lactic acid, and polycaprolactone fillers in mouse model
Authors: Kwon Tae‐Rin , Han Sung Won , Yeo In Kwon , Kim Jong Hwan , Kim Jae Min , Hong Ji‐Yeon , Lee Byung‐Chul , Lee Sung‐Eun , Moon Ho Sang , Kwon Han Jin , Kim Beom Joon 
Published: April 2019

SummaryBackgroundNumerous fillers are increasingly used for augmentation of volume loss and relaxation of facial wrinkles. Collagen stimulators are the latest next‐generation dermal fillers that can induce neocollagenesis. To investigate biophysical characteristics, safety, and efficacy of newly developed polydioxanone (PDO) filler in comparison with poly‐l lactic acid (PLLA) and polycaprolactone (PCL) fillers.MethodsIn vitro assay, morphology of particles, and rheological property of fillers were measured. A total of 24 female hairless mice (SKH1‐Hrhr) were randomly divided into three groups and injected with PDO, PLLA, or PCL fillers. Durability of fillers was assessed at 0, 3 days, and 1, 4, 8, 12 weeks after injection using folliscope and PRIMOS. To determine biocompatibility and neocollagenesis, histologic evaluation was performed at 1, 4, 8, and 12 weeks after injection. Efficacy was also evaluated based on skin surface roughness changes using PRIMOS in a hairless mouse photoaging model.ResultsIn the particle morphology test, PDO microspheres had an irregular surface and were spherical and uniformly sized. PDO filler demonstrated similar neocollagenesis and inflammatory response to other collagen stimulators. PDO filler showed better biodegradability than PLLA and PCL fillers. In the hairless mouse photoaging model, there was a statistically significant decrease in skin surface roughness after PDO filler injection.ConclusionsOur data suggest that newly developed collagen stimulating PDO filler might be a safe and effective option for correction of volume loss and rejuvenation of photoaging skin.
Nonlinearity and Flight‐to‐Safety in the Risk‐Return Trade‐Off for Stocks and Bonds
Authors: ADRIAN TOBIAS , CRUMP RICHARD K. , VOGT ERIK 
Published: April 2019

ABSTRACTWe document a highly significant, strongly nonlinear dependence of stock and bond returns on past equity market volatility as measured by the VIX. We propose a new estimator for the shape of the nonlinear forecasting relationship that exploits variation in the cross‐section of returns. The nonlinearities are mirror images for stocks and bonds, revealing flight‐to‐safety: expected returns increase for stocks when volatility increases from moderate to high levels while they decline for Treasuries. These findings provide support for dynamic asset pricing theories in which the price of risk is a nonlinear function of market volatility.
Impact of combined healthy lifestyle factors on survival in an adult general population and in high‐risk groups: prospective results from the Moli‐sani Study
Authors: Bonaccio M. , Di Castelnuovo A. , Costanzo S. , De Curtis A. , Persichillo M. , Cerletti C. , Donati M. B. , de Gaetano G. , Iacoviello L. ,   on behalf of the Moli‐sani Study Investigators
Published: April 2019

AbstractBackgroundThere is poor knowledge on the association between combined lifestyles with mortality risk among individuals at high risk, and little is known on the biological mechanisms that could be on the pathway.MethodsLongitudinal analysis on 22 839 individuals from the Moli‐sani Study (Italy, 2005–2010). Among them, we identified 5200 elderly individuals (≥65 year), 2127 subjects with diabetes and 1180 with cardiovascular disease (CVD) at baseline. A healthy lifestyle score (HLS) was calculated, allocating 1 point for each of the following: abstention from smoking; adherence to Mediterranean diet; physical activity; absence of abdominal obesity. Hazard ratios (HR) with 95% confidence intervals (95%CI) were calculated by multivariable Cox regression and competing risk models.ResultsDuring 8.2 years of follow‐up, 1237 deaths occurred. In the general population, adherence to all four healthy lifestyles, compared with none or 1, was associated with lower risk of all‐cause (HR = 0.53; 95%CI:0.39–0.72), CVD (HR = 0.54; 0.32–0.91), cancer (HR = 0.62; 0.39–1.00) and mortality from other causes (HR = 0.39; 0.19–0.81). A 1‐point increase in HLS was associated with 20%, 22% and 24% lower risk of total mortality among the elderly, in subjects with diabetes or CVD, respectively. Traditional (e.g. blood lipids), inflammatory (e.g. C‐reactive protein) and novel biomarkers (e.g. markers of cardiac damage) accounted for up to 24% of the association of HLS with all‐cause mortality risk in the general population.ConclusionsThe impact of combined four healthy lifestyles on survival was considerable, both in the general population and among high‐risk subgroups. Inflammatory and novel biomarkers of CVD risk explained a substantial proportion of this association.