bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of three-step mixing technology based on vibratory mixing on properties of high-strength concrete
Authors: Zhao Kaiyin , Zhao Lijun , Liu Shanshan , Hou Jinru 
Published: July 2019

Abstract
A large number of experimental studies have shown that both vibratory mixing and multi-step mixing processes can improve the workability of concrete and improve the strength and durability of high-strength concrete(HSC). In this paper, for C60 HSC, two kinds of mixin g methods: conventional compulsory mixing and vibratory mixing, two kinds of mixin g technology: one-step mixing technology and three-step mixing technology are used to carry out contrast test. The purpose is to study the influence of mixing meth od and mixing technology on the performance of HSC. The research results show that compared with the one-step mixin g technology, the three-step mixing technology can significantly reduce the plastic viscosity of the concrete, improve its fluidity, and significantly improve the compressive strength at the age of and after 28 days and 56 days under the condition of the conventional compulsory mixing and the vibratory mixing. And the study found that the most suitable mixing method and mixin g technology for C60 HSC are vibratory mixing method and three-step mixing technology.
Saponin, Polyphenol, Flavonoid content and α-glucosidase Inhibitory Activity, Antioxidant Potential of Launaea sarmentosa Leaves grown in Ben Tre province, Vietnam
Authors: Them Le Thi , Tuong Nguyen Dung Phu , Thi Nhat Trinh Pham , Tong Hung Quach , Tuong Vi Le Nguyen , Trong Tuan Nguyen , Duc Lam Tri , Thuy Nguyen Van , Dung Le Tien 
Published: July 2019

Abstract
Launaea sarmentosa (Willd) Schultz-Bip.ex Kuntze, a creeping herb, belongs to family Asteraceae. It is distributed in sandy coasts of India, Sri Lanka, Malaysia, East Africa and Vietnam. In Vietnamese folk medicine, whole plant possess tonic, soporific, diuretic, laxative properties and the roots are used to benefit milk for mothers after childbirth, instead of Lactuca indica. Up to now, the phytochemicals and bioactivities of this plant are not yet been examined. The present study was designed to investigate the saponin, polyphenol and flavonoid contents as well as α-glucosidase inhibitory and antioxidant activities of the leaves of L. sarmentosa. Preliminary phytochemical screening of this plant were found to give positive reactions for flavonoid, saponin, alkaloid, tannin, and steroid compounds. The result of quantitative determination showed that the leaves contains high amount of polyphenol compounds (290.90 mg GAEs/g extract), lower amount of flavonoids (85.47 mg QEs/g extract) and the saponin content was found to be 10.8 % (per dry weight). As expected, the ethanol extract had a antioxidant potential with IC50 value of 24.15 μg/mL in DPPH experiment, compared to that of vitamin C. Meanwhile, the α-glucosidase inhibitory assay showed inhibited enzyme activity with IC50 value of 67.09 μg/ml.
Effect of Zn on microstructure evolution of Mg-Gd-Y-Nd-Zn-Zr alloy during heat treatment
Authors: Li T , Chen D J , Liu W , Yuan J W , Qu J 
Published: July 2019

Abstract
The effect of Zn on the microstructure evolution of Mg-7Gd-3Y-1Nd-xZn-0.5Zr (x=1.0, 2.0) (wt.%) alloys during homogenization and ageing heat treatment has been investigated systemically. The results indicate that as-cast 1 Zn alloy is composed mainly of α-Mg, Mg5(RE, Zn) eutectic phase, (Mg, Zn)3RE eutectic phase, stacking faults and block-like compounds rich in RE. Increasing of Zn content result in the disappearance of Mg5(RE, Zn) eutectic phase, but the volume fraction of 14H-typ LPSO phase is increasing, which has made it even more difficult to dissolve into the matrix during homogenization. After homogenization at 520 °C for 48 h, the 14H LPSO phase remains in the alloys with 2 wt.% Zn, but only compounds rich in RE can be seen in the alloy with 1 wt.%Zn. After ageing at 240°C for 18 h, the coherent β′ phase can be found both in 1Zn and 2Zn alloys, resulting in the increase of mechanical properties. The β′, β1 and stacking faults can be found in 1Zn and 2Zn alloys after ageing at 240°C for 100 h. However, it can be concluded that Zn can suppress the formation of LPSO phases but impede the precipitation of β′ and β1 during the aging process. The as-aged alloy with 1% Zn addition shows the optimal mechanical properties.
Experimental study on process of carbon fiber composites based on high temperature epoxy system curing
Authors: Liu Mingfan , Tong Zhipei , Gao Lei , Zhang Peng , Cheng Yongqi , Sun Yousong 
Published: July 2019

Abstract
The carbon fiber reinforced composite materials used in sliding friction pairs was studied in the paper. A type resin matrix of epoxy CYD-128 with 4-4’ Diamond dipheny methane(DDM) was prepared, and the curing dynamics parameters under different heating rates were studied by DSC thermal analysis, the curing step as 100°C/2h+160°C/2h was assured according to the β extrapolation method; The exsistance and the content change of the characteristic functional groups in the cured epoxy resin were analysed by the Infrared spectrum of the cured epoxy resin; The carbon fibers were processed with vacuum impregnation technology after glued, and the tensile fracture of the sample was observed as well as the micro morphology by SEM. The tests showed that the tensile strength of carbon fiber composite had grown 18.9% and the compression strength increased 25.9% by vacuum impregnation, and the carbon fibers were closely combined with the epoxy resin.
Innovative Application of Digitized Design in Traditional Manufacturing: An Example in the Powder Metallurgy Industry
Authors: Jih-Sheng Lo , Lee Kim C K , Shyh-Chour Huang 
Published: July 2019

Abstract
This research began with a series of in-depth interview with experts in the field of powder metallurgy, combined with literature review, a design process with a checklist of design quality for powder metallurgy cultural and creative products was established. We first verified this design process with the checklist by applying it to improve the design of an existing powder metallurgy cultural and creative product. Then we designed three cultural and creative products based on the established design process with the checklist of design quality and chose an icon of Hakka Lion among them to prepare a toolset and finished the test production of a sample, which all of our interviewed experts deemed as having excellent quality. Therefore, this research verified that the traditional technology of powder metallurgy could not only be utilized to produce mechanical parts, but it can also be applied in the cultural and creative industry to produce high value-added artifacts that are typically full of very complex curvature surfaces. In addition, the design process with the checklist of design quality for powder metallurgy cultural and creative products was also verified to be applicable. Besides, this research also introduced the technology of digitized design to the design and manufacturing process of an old powder metallurgy manufacturer successfully. Through which we enhanced the integrity and efficiency of this production process significantly. Hope that the result of this research will be helpful for the powder metallurgy industry in Miao-li County of Taiwan to find a way out.
Design of Curling Sports Service Robot
Authors: Chunlai Tian , Qideng Chen , Quanquan Feng , Sichun Luo 
Published: July 2019

Abstract
In order to implement handling and unmanned maintenance for curling in sports, a service robot is designed in this paper. It could save professional labor costs and improve work efficiency for the curling sports service with strong usability. Through analysis on the curling’s feature, the mechanical model of the service robot is established by three-dimensional CAD software. The robot consists two functional sub robots. One is the curling handling robot and the other one is the curling maintenance robot. The design includes the robotic arm systems, maintenance systems, intelligent identification, industrial CT inspection systems and pneumatic control systems. Referred to the mechanical structure of the excavator, the mechanical arm movement is driven by the cylinder. The handling curling has strong stability. The maintenance system adopts a circular layout design. The simulated motion of the design is carried out with the rationality of mechanical structure analyzed. It can make reasonable serve sports and improve work efficiency significantly.
The Control Method of Pigging Slug Flow for Multiphase Subsea Pipeline
Authors: Meng Li , Hao Xu 
Published: July 2019

Abstract
This paper analyses the causes of the large number of slug flows by OLGA software and analyses its control methods. It can be seen from the simulation that closing the high-production gas well to control the pigging flow rate and venting time can effectively control the volume of the pigging slug flow, thereby reducing the volume of the slug flow trap and reducing the platform area, thereby reducing the overall engineering investment.
Resource use for older people hospitalised due to injury in a Canadian integrated trauma system: a retrospective multicenter cohort study
Authors: Farhat Imen , Moore Lynne , Porgo Teegwendé Valérie , Patton Marie-Pier , Tardif Pier-Alexandre , Truchon Catherine , Berthelot Simon , Stelfox Henry T , Gabbe Belinda J , Lauzier François , Turgeon Alexis F , Clément Julien 
Published: July 2019

Abstract

Background
Injuries represent one of the leading causes of preventable morbidity and mortality. For countries with ageing populations, admissions of injured older patients are increasing exponentially. Yet, we know little about hospital resource use for injured older patients. Our primary objective was to evaluate inter-hospital variation in the risk-adjusted resource use for injured older patients. Secondary objectives were to identify the determinants of resource use and evaluate its association with clinical outcomes.

Methods
We conducted a multicenter retrospective cohort study of injured older patients (≥65 years) admitted to any trauma centres in the province of Quebec (2013–2016, N = 33,184). Resource use was estimated using activity-based costing and modelled with multilevel linear models. We conducted separate subgroup analyses for patients with trauma and fragility fractures.

Results
Risk-adjusted resource use varied significantly across trauma centres, more for older patients with fragility fractures (intra-class correlation coefficients [ICC] = 0.093, 95% CI [0.079, 0.102]) than with trauma (ICC = 0.047, 95% CI = 0.035–0.051). Risk-adjusted resource use increased with age, and the number of comorbidities, and varied with discharge destination (P < 0.001). Higher hospital resource use was associated with higher incidence of complications for trauma (Pearson correlation coefficient [r] = 0.5, 95% CI = 0.3–0.7) and fragility fractures (r = 0.5, 95% CI = 0.3–0.7) and with higher mortality for fragility fractures (r = 0.4, 95% CI = 0.2–0.6).

Conclusions
We observed significant inter-hospital variations in resource use for injured older patients. Hospitals with higher resource use did not have better clinical outcomes. Hospital resource use may not always positively impact patient care and outcomes. Future studies should evaluate mechanisms, by which hospital resource use impacts care.
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis
Authors: Tyzack Giulia E , Luisier Raphaelle , Taha Doaa M , Neeves Jacob , Modic Miha , Mitchell Jamie S , Meyer Ione , Greensmith Linda , Newcombe Jia , Ule Jernej , Luscombe Nicholas M , Patani Rickie 
Published: July 2019

Abstract
Mutations causing amyotrophic lateral sclerosis (ALS) clearly implicate ubiquitously expressed and predominantly nuclear RNA binding proteins, which form pathological cytoplasmic inclusions in this context. However, the possibility that wild-type RNA binding proteins mislocalize without necessarily becoming constituents of cytoplasmic inclusions themselves remains relatively unexplored. We hypothesized that nuclear-to-cytoplasmic mislocalization of the RNA binding protein fused in sarcoma (FUS), in an unaggregated state, may occur more widely in ALS than previously recognized. To address this hypothesis, we analysed motor neurons from a human ALS induced-pluripotent stem cell model caused by the VCP mutation. Additionally, we examined mouse transgenic models and post-mortem tissue from human sporadic ALS cases. We report nuclear-to-cytoplasmic mislocalization of FUS in both VCP-mutation related ALS and, crucially, in sporadic ALS spinal cord tissue from multiple cases. Furthermore, we provide evidence that FUS protein binds to an aberrantly retained intron within the SFPQ transcript, which is exported from the nucleus into the cytoplasm. Collectively, these data support a model for ALS pathogenesis whereby aberrant intron retention in SFPQ transcripts contributes to FUS mislocalization through their direct interaction and nuclear export. In summary, we report widespread mislocalization of the FUS protein in ALS and propose a putative underlying mechanism for this process.
The Demographic Transition and the Position of Women: a Marriage Market Perspective
Authors: Bhaskar V 
Published: July 2019

Abstract
Secular trends in cohort size cause large marriage market imbalances due to the age gap at marriage between men and women. Positive cohort growth adversely affects women in South Asia and sub-Saharan Africa. Secular decline improves their position in East Asia. I show that the age gap at marriage will not adjust in order to equilibrate the marriage market in response to persistent imbalances, even though it accommodates transitory shocks. This implies large distributional consequences on the sexes, and may increase dowries. I also analyse transition dynamics between steady states and examine how age gaps and transfers adjust in the transition.
QTL analysis of naturalSaccharomyces cerevisiaeisolates reveals unique alleles involved in lignocellulosic inhibitor tolerance
Authors: de Witt R N , Kroukamp H , Van Zyl W H , Paulsen I T , Volschenk H 
Published: July 2019

ABSTRACTDecoding the genetic basis of lignocellulosic inhibitor tolerance in Saccharomyces cerevisiae is crucial for rational engineering of bioethanol strains with enhanced robustness. The genetic diversity of natural strains present an invaluable resource for the exploration of complex traits of industrial importance from a pan-genomic perspective to complement the limited range of specialised, tolerant industrial strains. Natural S. cerevisiae isolates have lately garnered interest as a promising toolbox for engineering novel, genetically encoded tolerance phenotypes into commercial strains. To this end, we investigated the genetic basis for lignocellulosic inhibitor tolerance of natural S. cerevisiae isolates. A total of 12 quantitative trait loci underpinning tolerance were identified by next-generation sequencing linked bulk-segregant analysis of superior interbred pools. Our findings corroborate the current perspective of lignocellulosic inhibitor tolerance as a multigenic, complex trait. Apart from a core set of genetic variants required for inhibitor tolerance, an additional genetic background-specific response was observed. Functional analyses of the identified genetic loci revealed the uncharacterised ORF, YGL176C and the bud-site selection XRN1/BUD13 as potentially beneficial alleles contributing to tolerance to a complex lignocellulosic inhibitor mixture. We present evidence for the consideration of both regulatory and coding sequence variants for strain improvement.
Skp1 isoforms are differentially modified by a dual function prolyl 4-hydroxylase/N-acety lglucosaminyltransferase in a plant pathogen
Authors: van der Wel Hanke , Gas-Pascual Elisabet , West Christopher M 
Published: July 2019

Abstract
Skp1 is hydroxylated by an O2-dependent prolyl hydroxylase (PhyA) that contributes to O2-sensing in the social amoeba Dictyostelium and the mammalian pathogen Toxoplasma gondii. HO-Skp1 is subject to glycosylation and the resulting pentasaccharide affects Skp1 conformation in a way that influences association of Skp1 with F-box proteins, and potentially the assembly of E3(SCF) ubiquitin ligase complexes that mediate the polyubiquitination of target proteins that are degraded in the 26S-proteasome. To investigate the conservation and specificity of these modifications, we analyzed proteins from the oomycete Pythium ultimum, an important crop plant pathogen. Putative coding sequences for Pythium’s predicted PhyA and first glycosyltransferase in the predicted five-enzyme pathway, a GlcNAc-transferase (Gnt1), predict a bifunctional enzyme (Phgt) that, when expressed in Dictyostelium, rescued a knockout of phyA but not gnt1. Though recombinant Phgt was also unable to glycosylate Dictyostelium HO-Skp1, it could hydrolyze UDP-GlcNAc and modify a synthetic hydroxypeptide from Dictyostelium Skp1. Pythium encodes two highly similar Skp1 isoforms, but only Skp1A was efficiently hydroxylated and glycosylated in vitro. While kinetic analysis revealed no evidence for processive processing of Skp1, the physical linkage of the two activities implies dedication to Skp1 in vivo. These findings indicate a widespread occurrence of the Skp1 modification pathway across protist phylogeny, suggest that both Gnt1 and PhyA are specific for Skp1 and indicate that the second Skp1 provides a bypass mechanism for O2-regulation in Pythium and other protists that conserve this gene.
Instruments for the Assessment of Behavioral and Psychosocial Functioning in Duchenne and Becker Muscular Dystrophy; a Systematic Review of the Literature
Authors: Hellebrekers Danique M J , Lionarons Judith M , Faber Catharina G , Klinkenberg Sylvia , Vles Johan S H , Hendriksen Jos G M 
Published: July 2019

AbstractObjectiveThis systematic review aims to provide an overview of instruments used to assess behavioral and psychosocial functioning of patients with Duchenne and Becker muscular dystrophy, as well as to review the psychometric properties and applicability of these instruments.MethodsFive databases (Embase, Psyc.info, ERIC, Pubmed/Medline, and Cochrane) were searched from inception to June, 2018. Potential articles were rated by two independent reviewers. A predefined PROSPERO form (CRD42017074518) was used to extract data from included articles.ResultsSixty-one instruments were used in 54 studies. The Child Behavior Checklist is commonly used, but it lacks disease specific psychometric information. Sixteen instruments that contained disease specific psychometric information were included for final evaluation. The results displayed three instruments that are potentially valid for screening of psychosocial problems: The Psychosocial Adjustment and Role Skills Scale 3rd edition, the Pediatric Quality of Life Inventory Generic module, and the Life Satisfaction Index for Adolescents with Duchenne muscular dystrophy. Appropriate instruments for screening of behavioral problems may be: the Strengths and Difficulties Questionnaire, the Generalized Anxiety Disorder-7 item questionnaire, and the Patient Health Questionnaire-9 item questionnaire.ConclusionsFurther research on psychometric properties of screening instruments is crucial to ascertain a gold standard for clinical and research purposes. Meanwhile, for definite diagnostics purposes we recommend a multimethod, multisource, multisetting assessment in this high-risk population.
Companion-driven evolution of massive stellar binaries
Authors: Rose Sanaea C , Naoz Smadar , Geller Aaron M 
Published: July 2019

ABSTRACT
At least $70\, {\rm per\, cent}$ of massive OBA-type stars reside in binary or higher order systems. The dynamical evolution of these systems can lend insight into the origins of extreme phenomena such as X-ray binaries and gravitational wave sources. In one such dynamical process, the Eccentric Kozai–Lidov (EKL) mechanism, a third companion star alters the secular evolution of a binary system. For dynamical stability, these triple systems must have a hierarchical configuration. We explore the effects of a distant third companion’s gravitational perturbations on a massive binary’s orbital configuration before significant stellar evolution has taken place (≤10 Myr). We include tidal dissipation and general relativistic precession. With large (38 000 total) Monte Carlo realizations of massive hierarchical triples, we characterize imprints of the birth conditions on the final orbital distributions. Specifically, we find that the final eccentricity distribution over the range of 0.1–0.7 is an excellent indicator of its birth distribution. Furthermore, we find that the period distributions have a similar mapping for wide orbits. Finally, we demonstrate that the observed period distribution for approximately 10-Myr-old massive stars is consistent with EKL evolution.
The distinct stellar metallicity populations of simulated Local Group dwarfs
Authors: Genina Anna , Frenk Carlos S , Benítez-Llambay Alejandro , Cole Shaun , Navarro Julio F , Oman Kyle A , Fattahi Azadeh 
Published: July 2019

ABSTRACTA number of Local Group dwarf galaxies are known to have two spatially segregated stellar metallicity populations, a centrally concentrated metal-rich population, and a more extended metal-poor population. In this work we discuss mechanisms that lead to the formation of two spatially segregated metallicity populations. Using a set of high-resolution hydrodynamical simulations of Local Group-like environments, we select a sample of satellite and field galaxies, spanning the stellar mass range 106–109 M⊙, that exhibit bimodality in their metallicity distributions. Among those, we identify a subsample with a strong spatial segregation in the two populations. We find three distinct mechanisms for their formation. In field dwarfs and in a small fraction of satellites, a merger causes the metal-poor stars to migrate to larger radii and encourages the available gas to sink to the centre of the dwarf. Most of the gas is subsequently blown out of the halo through star formation feedback, but the remaining gas is consumed in the formation of a metal-rich population. In the exclusive case of satellites that have retained some of their gas at infall, it is the compression of this gas by ram pressure near pericentre that triggers the formation of metal-rich stars, whilst simultaneously preventing star formation at larger radii through stripping. Additionally, in a small number of field and satellite dwarfs, interactions with gaseous filaments and other galaxies can result in the formation of a metal-rich population. Regardless of the formation mechanism, a history of mergers typically enhances the spatial segregation.