bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of Brinzolamide Loaded Microemulsion using Formulation by Design Approach: Characterization and <l>In-vitro</i> Evaluation
Authors: Gohil Riyaz , Patel Asha , Pandya Tosha , Dharamsi Abhay 
Published: January 2019

Background:
The clinical application of Brinzolamide, a drug used in the treatment of
glaucoma is limited due its poor aqueous solubility. Microemulsion based ocular delivery can be an
effective means to improve its solubility and in turn the bioavailability.

Objective:
The main objective of the present work was optimization and characterization of Brinzolamide
loaded microemulsion for the treatment of glaucoma.

Method:
The solubility of Brinzolamide in various oils and surfactants was checked in order to
identify components of microemulsion. Pseudo-ternary phase diagram using Prosim software was
plotted to identify microemulsion existence area. D-optimal mixture design was used for optimization
of microemulsion. The optimized formulation consisted of Isopropyl myristate, Tween-80 and
Transcutol-P as surfactant and co-surfactant respectively, and water. The chosen critical responses
were droplet size, zeta potential, nepheloturbidimetric unit, and viscosity.

Results:
The selected optimal composition shows favorable features, such as droplet size (41.69
nm), Zeta potential (-9.496 mV), Viscosity (170.8 cps), Transparency (1.483 NTU) and pH (7.646)
that are suitable for ocular delivery. Moreover, a prolonged drug release (78.08 % within 7 hour)
was found in in-vitro experiments. By and large the formulation was found to be safe and nonirritant
as proven by the ocular irritation study.

Conclusion:
Our study illustrated potential of Brinzolamide loaded microemulsion for ocular delivery
for the treatment of glaucoma.
Pengaruh Pemberian Ekstrak Sarang Semut (Myrmecodia sp.) Terhadap Fertilitas Telur Ayam
Authors: Lisnanti Ertika Fitri , Mukmin Amiril , Fitriyah Nur 
Published: January 2019

Tujuan dari penelitian ini ialah untuk mengetahui pengaruh pemberian ekstrak sarang semut terhadap peningkatan fertilitas telur ayam. Penelitian ini dilakukan dengan metode eksperimen dengan rancangan acak lengkap pola faktorial (RALF). Faktor I = level pemberian ekstrak umbi sarang semut yang terdiri dari 2 level yaitu L1(10 mg/kg BB) dan L2 (20 mg/kg BB), sedangkan Faktor II = durasi pemberian ekstrak umbi sarang semut yang terdiri dari 3 level yaitu D0 (0 hari/minggu), D3 (3 hari/minggu) dan D5 (5 hari/minggu). Hasil penelitian menunjukkan bahwa berdasarkan analisa statistik diketahui terdapat interaksi yangÂ nyata (P<0,05) antara kombinasi perlakuan level pemberianÂ dan durasi pemberian ekstrak umbi sarang semut terhadap fertilitas telur ayam. Pemberian ekstrak sarang semut pada level 10 mg/kg BB dengan durasi pemberian selama 5 hari/minggu (LID5) secara sinifikan mampu meningkatkan fertilitas telur ayam (97,58%) jika dibandingkan dengan perlakuan yang lain (L2D3 = 94,38%; L2D5 = 94,32%; L1D3 = 93,28%; L2D0 = 92,90%; dan L1D0 = 2,84%). Kesimpulan yang dapat diambil ialah untuk dapat meningkatkan fertilitas telur ayam, level dan durasi pemberian ekstrak sarang semut harus tepat karena jika tidak, nilai peningkatannya tidak akan optimal, sekalipun dengan level dan durasi pemberian yang lebih tinggi.
Requiem. Resonanzen katholischer Totenliturgie in Vergangenheit und Gegenwart
Authors: Quartier Thomas 
Published: January 2019

Liturgical music at Roman-Catholic funerals has a very diverse character in contemporary Western society, especially in a strongly secularized country like the Netherlands. The spectrum covers the favorite music of the deceased as well as traditional chants. But how is it possible that people still frequently opt for the Requiem, even outside the classical liturgical context? In this article, we explore the concepts of experience and meaning with regard to the Requiemmass. Which kind of experience belongs to this type of liturgical chant? And which meaning is ascribed to it? Using the resonance-theory of Hartmut Rosa, we distinguish a liturgical horizontal dimension (shared experience) and a vertical dimension (religious meaning). Diagonal resonance refers to the liturgical elements of singing. By referring to striking examples from the history of Christian worship, we show that experience and meaning of liturgical chant always depended on its context. It changed; meaning differed from experience and covered it again. For contemporary liturgical practice it would therefore be too simple to only speak about an experiential dimension of the Requiem and no longer about its meaning. The aim must be to combine a personalized meaning with the tradition of ecclesial liturgy.
FACTORS THAT AFFECT TAXPAYER COMPLIANCE IN KPP PRATAMA GAMBIR 4 2018
Authors: Akbar Fhatur , Nuryatno Muhammad 
Published: January 2019

Tax is one of the main resources in the implementation of activities such as taxes that are taxed will be difficult to do from the tax sector. This study aims to find out and know the duties of taxes, taxes required, taxes, and tax avoidance on taxes. This data uses primary data as data obtained from data used in the Gambir Empat Primary KPP environment. The sample used was 125 respondents registered at the KPP Pratama Jakarta Gambir Empat. Data collection using purposive sampling method and analyzed using the SPSS version 24 application.The results of this study show the results in general and the variables of of positive taxpayers. Therefore, all the hypotheses in this study can be accepted.
REAL E IMAGINÁRIO NO BRINCAR. REAL AND IMAGINARY IN PLAYING
Authors: Pisetta Maria Angelica Augusto de Mello , Da Conceição Larissa Silva 
Published: January 2019

Propomos suscitar uma reflexão acerca da infância em seus processos intrínsecos, como o brincar, o fantasiar e o estabelecimento da linguagem enquanto possibilitadores da experiência de aprendizagem necessária à emergência do sujeito. Ressaltaremos a importância do brincar como processo de constituição psíquica e pertencimento ao mundo a partir da análise de conceitos psicanalíticos, especialmente daqueles desenvolvidos por Winnicott, Lacan e Levin. Analisaremos o brincar na atualidade, onde se desvela a utilização excessiva da imagem midiática já na primeira infância, num predomínio do imaginário e do consumismo, onde o brinquedo perde sua função de articulação da fantasia e passa a ser objeto de consumo e posse.
O PÚBLICO-ALVO DA EDUCAÇÃO ESPECIAL NA EDUCAÇÃO INFANTIL DE NITERÓI: ENTRE DIAGNÓSTICOS E DIREITOS. THE TARGET AUDIENCE OF SPECIAL EDUCATION IN EARLY CHILDHOOD EDUCATION FROM NITERÓI: BETWEEN DIAGNOSTICS AND RIGHTS
Authors: Dos Santos Fernanda Viannay Siqueira , Dos Santos Rosane Barreto Ramos , De Queiroz Paulo Pires 
Published: January 2019

Considerando a especificidade da educação especial na perspectiva inclusiva e a dificuldade na execução de políticas públicas favoráveis ao processo de inclusão dos alunos com deficiência, objetivamos, neste trabalho, investigar os critérios de identificação e de inclusão dos alunos, público-alvo da educação especial da Rede Municipal de Niterói. Para isso, examinamos os documentos oficiais da política de educação inclusiva do município. Na tentativa de contribuir para desvelar caminhos que atendam às expectativas direcionadas para um atendimento de qualidade, este trabalho pontua os avanços e retrocessos da educação inclusiva na Rede Municipal de Niterói, destacando a necessidade de articulação entre os sistemas de apoio, responsáveis pela promoção da educação inclusiva na Rede.
NOTAS SOBRE CINEMA E EXPERIÊNCIA DE FORMAÇÃO ESTÉTICA NUMA PERSPECTIVA EMANCIPATÓRIA. NOTES ON CINEMA AND AESTHETIC TRAINING EXPERIENCE FROM AN EMANCIPATORY PERSPECTIVE
Authors: Pereira Márcia Ferreira Torres 
Published: January 2019

O artigo enfatiza estudos sobre estética, educação e imagens da arte, considera a reflexão filosófica acerca da realidade histórico-cultural contemporânea, do conceito e do sentido da formação estética como possibilidade de emancipação humana, na trajetória dos teóricos: Aumont; Badiou; Haroche e Aubert; Kracauer; Schiller; Wulf; Adorno; Horkheimer e Benjamin. A estética como conhecimento histórico exige reflexão, considera as percepções sensíveis, propõe uma educação crítica e a busca pelo conhecimento capaz de oportunizar o movimento do pensamento ético e político na condução de outros conhecimentos. O estudo sobre o cinema, como manifestação artística, abarca aspectos filosóficos e estéticos no contexto de suas relações com o saber e sua contribuição para o processo de formação.
PERKEMBANGAN ORGANISASI KEPROFESIAN TI DI INDONESIA
Authors: Watef Luluk , Oktavia Dea Ayu , Pradani Humaira Nur , Revandhika Naufal Ihza , Wicaksono Muhamad Kemal , Rakhmawati Nur Aini 
Published: January 2019

Perkembangan Teknologi Informasi dan Komunikasi menjalar sangat cepat dan semakin mudah di jangkau. Penggunaan TI sekarang sudah menjadi kebutuhan dan tuntutan di setiap lembaga yang ada di Indonesia. Teknologi Informasi dan Komunikasi menjadikan sharing informasi dapat dilakukan semudah mengetikkan kata dan menekan tombol di smartphone. Informasi yang semakin mudah ini menjadikan banyaknya sekumpulan orang yang tertarik dengan dunia TI dan membentuk berbagai perkumpulan TI salah satunya adalah asosiasi TI. Pada penelitian ini sampel dari asosiasi-asosiasi profesi TI di Indonesia dibandingkan berdasarkan waktu berdirinya, bidangnya, dan tujuannya dibuatnya asosiasi tersebut. Informasi tentang asosiasi-asosiasi profesi TI di Indonesia diperoleh melalui pengumpulan data dari website asosiasi terkait. Topik ini menjadi menarik untuk diketahui sebagai sebuah indikator bagaimana tren TI berkembang dilihat dari berbagai dimensi yang tersedia pada sebuah asosiasi. Analisis dilakukan untuk mengetahui perkembangan TI di Indonesia. Analisis dilakukan setelah pengumpulan data, reduksi data yang ada, kemudian mulai menganalisis dan menyajikan data- data yang penting, dan menarik kesimpulan. Penelitian ini menghasilkan kesimpulan bahwa pembentukan asosiasi TI sangat erat kaitannya dengan tren IT yang sedang terjadi di Indonesia. Tujuan masing-masing asosiasi yang dibentuk juga disesuaikan dengan kebutuhan masyarakat. Namun, meskipun begitu kita dapat menarik satu benang merah diantara keberagaman tujuan asosiasi-asosiasi TI tersebut, yaitu mengembangkan lingkungan TI di Indonesia.
APLIKASI PERANCANGAN PEMBAGIAN LABA SAHAM PADA PT. APLIKASI KARYA ANAK BANGSA (GOJEK)
Authors: Sitio Hany Juliana 
Published: January 2019

PT Aplikasi Karya Anak Bangsa (GO-JEK) adalah sebuah perusahaan teknologi dengan misi sosial untuk meningkatkan kesejahteraan dan mata pencaharian pekerja di berbagai sektor informal di Indonesia. Perusahaan ini berkembang cukup pesat di Indonesia sehingga perusahaan ini mendapat banyak apresiasi dari berbagai Perusahaan lain dengan menanamkan saham pada PT. Apliaksi Karya Anak Bangsa (GO-JEK) ini. Dengan banyaknya perusahaan yang menanamkan modal maka PT Aplikasi Karya Anak Bangsa ini memerlukan aplikasi untuk informasi saham dan informasi keuntungan yang didapatkan oleh investor. Penelitian dengan judul “Aplikasi Perancangan Pembagian saham mepada PT. Aplikasi Karya Anak Bangsa” dirancang menggunakan Entity Relation Diagram, Data flow diagram, dan menggunakan Microsoft Visual Studio sebagai programnya, dan MySQL sebagai databasenya. Perancangan aplikasi ini nantinya diharapkan bisa digunakan untuk mempermudah investor dan perusahaan untuk mengetahui laba saham setiap investor.
Anti Klimaks Implementasi E-Government: Analisis Partisipasi Masyarakat Petani Di Kabupaten Gunungkidul
Authors: Wicaksono Ferri 
Published: January 2019

This research is located in Gunungkidul Regency, Yogyakarta Special Region (DIY). The rapid development of global information technology has driven a paradigm shift in society towards the era of digital society. This fact directs the massive use of electronic media in the public service bureaucracy in Indonesia. In order to realize a clean, transparent public service and be able to answer the demands of change effectively, in line with Presidential Instruction No. 3 of 2003. Dilemma when the Gunungkidul Regency Government is seeking e-government as a reform of the public service bureaucracy that is intended for the community as the recipient of service benefits, there are elements of farmer communities that tend to be difficult to adopt new technologies. The Gunungkidul Regency Government has consistently developed a website up to the sub-district level totaling 18 sub-districts and village levels totaling 144 villages with domains namely "name of village-sub-districts.desa.id", known as the Village Information System (SID). The author uses descriptive exploratory research methods to explain the limitations of peasant communities in the use of e-government. This situation can trigger barriers to optimizing the implementation of e-government in Indonesia. The author finds the limitations of the farming community in Gunungkidul Regency in the use of e-government due to 2 (two) aspects namely the lack of habituation in the use of information technology media and the characteristics of community associations that are inherent in the social activities of farmers in Gunungkidul Regency. The character of the farming community tends to be difficult to correlate with the development of digital information technology in its activities, making it difficult to create an habit of using internet media for everyday life. Keywords: e-government, public service, farmer community, limitations
Strategi Pelayanan dalam Menangani Keluhan Masyarakat tentang Penerangan Jalan Umum di Unit Pelaksana Tehnis Penerangan Jalan Umum Dinas Kebersihan dan Pertamanan Kota Surabaya
Authors: Isdianto Erwin , Dwijosusilo Kristyan 
Published: January 2019

Aparatur di Unit Pelaksana Tehnis (UPT) Penerangan Jalan Umum (PJU) Dinas Kebersihan dan Pertamanan kota Surabaya dapat menangani keluhan masyarakat terkait keluhan terhadap PJU di Surabaya. Keluhan yang masuk ditangani dengan pertimbangan urgensi / ketersediaan spare part. Semua jajaran di UPT Penerangan Jalan, mulai Kepala Dinas, Kepala Bidang, Kepala Seksi, hingga Kepala Rayon terlibat dalam penanganan PJU. Pada saat siang hari diterima oleh petugas bidang administrasi yang menerima dan merekap keluhan, lalu dilaporkan ke Kepala Rayon. Bila laporan pada malam hari, ada petugas bidang posko yang akan menerima dan langsung dilaporkan ke petugas lapangan. Karena keterbatasan aparatur, semua keluhan yang masuk, tentu akan memerlukan waktu untuk ditangani, jadi, semua keluhan tetap akan ditangani, namun memerlukan waktu. Bila tidak ditangani disaat setelah melaporkan, warga dapat melaporkan keluhannya kembali, sampai dengan keluhan tersebut dapat ditangani oleh petugas.Hubungan antara masyarakat dan Dinas, dalam hal ini UPT Penerangan Jalan Umum, sifatnya 1 arah, warga melaporkan keluhan, petugas menindak lanjuti hubungan bisa menjadi dua arah, bila warga melaporkan keluhannya melalui media, baik itu media massa maupun media sosial. Setelah warga melaporkan keluhannya dan akan di follow up oleh Kepala Seksi atau Kepala Rayon dan warga dapat mendapatkan feedback atau tanggapan dari Kepala BIdang, Kepala Seksi atau Kepala Rayon mengenai status keluhan, yang sudah ditangani oleh petugas.Dalam setiap list keluhan warga, Kepala Seksi menetapkan prioritas – prioritas, hasil cek lokasi ke lapangan oleh Kepala Rayon, untuk mana saja lokasi yang lebih dulu ditangani, berdasarkan pertimbangan urgensi dan ketersediaan alat dan bahan. Kata Kunci : Strategi, Pelayanan, Keluhan Publik, PJU
Upaya Pencegahan Terorisme di Provinsi Riau (Studi Kasus Ditreskrimum Polda Riau)
Authors: Rama Silvi Dwi 
Published: January 2019

Terrorism is a transnational crime most feared by the world, not to mention Indonesia. Already many who became victims of terrorism crimes one of the tragedy is the bom Bali that link hundreds of souls. In Indonesia, especially in Riau continue to spread terrorism prevention efforts so terrorism crime does not occur in Riau Province. Prevention needs to be done considering the province of Riau began as a transit area of ​​terrorism because it is a region. The purpose of this research is to know what is done by Ditrekrimum Polda Riau in doing prevention of terrorism.The research conducted on Polda Riau which is located at Jalan Jenderal Sudirman no. 215 Pekanbaru, with the subject of research is Ditreskrimum Polda Riau and the result of his research is the prevention of terrorism in Riau Province by Ditreskrimum Polda Riau. The method used is qualitative research method with data technique is interview, observation and documentation. Data analysis using qualitative descriptive method. In this research the informant is Kasubdit 1 State Security Ditreskrimum Polda Riau and Kanit III Subdit 1 Ditreskrimum Polda Riau, as well as one member subdit I Ditreskrimum Polda Riau, as a complementary informant to support the research information. From the results of the research can be concluded that the efforts of terrorism have fulfilled the concept of (Darmawan, 2013). Prevention, prevention, prevention, prevention, prevention, prevention, mitigation, and repressive or arrest measures. In doing the prevention of Polda Riau Ditreskrimum also have conformity with awareness to other society, less effective performance of RT / RW area in which become target of terrorist is difficult to access area.
ANALISIS KEPUTUSAN PEMBELIAN JASA PENAMBANGAN PT BERAU COAL KEPADA PT BUKIT MAKMUR MANDIRI UTAMA (BUMA)
Authors: Sitio Arifin , Rasjid Beni 
Published: January 2019

This study aims to find out the influence of the quality of services, people, processes and physical evidence on the decision to purchase mining services by PT Berau Coal to PT BUMA. In this study, data collection was carried out through survey methods by distributing questionnaires to respondents within the company organization PT Berau Coal starting from the position of supervisor /engineer to general manager. The number of samples taken in this study was 50 people. Thetechnique sampling used in this study is Simple Random Sampling. Data analysis method uses multiple regression analysis with SPSS 23.0. The results of data processing show that the variable quality of services, people, processes and physical evidence affect the decision to purchase mining services. Parameters for testing the effect of service quality on service purchasing decisions show a t value of 3.191 (sig = 0.003), the influence of people on the decision to purchase services shows a t value of 2.341 (sig = 0.024), the effect of the process on the decision to purchase services shows a t value of 2.400 ( sig = 0.021), and the effect of physical evidence on the decision to purchase services shows a t value of 2.797 (sig = 0.008). Penelitian ini bertujuan untuk mengetahui pengaruh kualitas layanan, orang, proses dan bukti fisik terhadap keputusan pembelian jasa penambangan oleh PT Berau Coal kepada PT BUMA. Dalam penelitian ini, pengumpulan data dilakukan melalui metode survei dengan menyebarkan kuesioner kepada responden dalam organisasi perusahaan PT Berau Coal mulai dari posisi supervisor / insinyur hingga general manager. Jumlah sampel yang diambil dalam penelitian ini adalah 50 orang. Teknik sampling yang digunakan dalam penelitian ini adalah Simple Random Sampling. Metode analisis data menggunakan analisis regresi berganda dengan SPSS 23.0. Hasil pengolahan data menunjukkan bahwa variabel kualitas layanan, orang, proses dan bukti fisik mempengaruhi keputusan untuk membeli jasa penambangan. Parameter untuk menguji pengaruh kualitas layanan pada keputusan pembelian layanan menunjukkan pada nilai 3,191 (sig = 0,003), pengaruh orang pada keputusan untuk membeli layanan menunjukkan pada nilai 2,331 (sig = 0,024), efek dari proses pada keputusan untuk membeli layanan menunjukkan pada nilai 2.400 (sig = 0,021), dan pengaruh bukti fisik pada keputusan untuk membeli layanan menunjukkan pada nilai 2,797 (sig = 0,008).Keywords : Quality of services, people, processes and physical evidence, service purchasing decisions
Perangkat Pembelajaran IPA Model 5E : Kajian Kritis Hasil Workshop Guru-Guru Anggota MGMP IPA Kota Mataram
Authors: Jekti Dwi Soelistya Dyah , Bachtiar Imam , Sedijani Prapti , Zulkifli Lalu , Setiadi Dadi 
Published: January 2019

Abstrak: Kurikulum Mata Pelajaran IPA SMP tahun 2017 di Kota Mataram menuntut para guru IPA untuk bisa meningkatkan keterampilan dalam mengembangkan perencanaan dan mengimplementasikannya secara baik. Salah satunya adalah guru IPA SMP bisa mengembangkan perangkat pembelajaran. Untuk dapat mengembangkan perangkat pembelajaran IPA sesuai dengan standar, para guru IPA harus memiliki keterampilan dalam mengembangkan perangkat pembelajaran, Para guru masih terpaku dengan meodel yang disarankan kemnetrian terkait, sementara banyak model pembelajaran berbasisi siswa aktif salah satunya model 5E (Engage, Explore, Explain, Extend dan Evaluate). Oleh karena itu perlu dilakukan kegiatan untuk mengmbangkan keterampilan bapak/ibu guru IPA anggota MGMP IPA dalam perangkat pembelajaran model 5E. Desain yang digunakan adalah post tes no control group design. Populasi adalah semua guru IPA anggota MGMP Kota Mataram, sampel yang digunakan sebanyak 40 guru. Pengumpulan data dilakukan dengan mengevaluasi produk berupa perangkat pembelajaran hasil kegiatan workshop. Data dianalisis deskriptif kuantitatif. Hasil menunjukan bahwa perangkat pembelajaran yang disusun oleh guru peserta (90%) sudah baik dalam merencanakan langkah-langkah 5E. Tetapi dalam kaitannya dengan tagihan dan pengetahuan sebagian besar perangkat pembelajaran kurang mencakup keluasan dan kedalaman materi yang ditagih oleh kompetensi dasar pengetahuan dan keterampilan. Dengan demikian walaupun langkah-langkah pembelajaran berbasis siswa aktif dan memenuhi tagihan kurikulum tetapi tingkat asesmen belum memenuhi tagihan. Berdasarkan hasil penjelasan di atas dapat disimpulkan bahwa 90% bapak ibu guru IPA dapat menyusun perangkat pembelajaran cukup baik khususnya terkait sintaks 5E. Kata Kunci : pembelajaran IPA, model 5E, kajian kritis
Pelatihan Pembuatan dan Pendampingan Penerapan Multimedia Genggam Si Dio (Camtasia Studio) Berbasis Android bagi Tutor PKBM di Kabupaten Kuningan
Authors: Wati Dyah Puteria , Sahrir Dede Cahyati , Lutfi Ahmad Fajri 
Published: January 2019

TRAINING ON MAKING AND MENTORING ANDROID-BASED APPLICATION OF HANDHELD SI DIO (CAMTASIA STUDIO) MULTIMEDIA FOR PKBM TUTORS IN KUNINGAN REGENCY. Equality education of study group Package C is one of the non-formal education programs for people’s equivalent to high school level. One of the problems faced in the learning process of Package C program held by PKBM Kuningan city is not maximize the use of learning media, especially in the field of technology. This community service activity will be held in PKBM Kuningan city which already has NPSN. The purpose of this training is to improve tutor skills in making and implementing learning by utilizing android-based smartphone as a medium of learning. The method of training implementation consists of several stages: training licensing, training preparation, preparation of training module book, Si Dio handheld multimedia training, mentoring of media usage already made by tutor. Based on the results of training and mentoring the application of handheld multimedia Si Dio based on android this can help improve and improve the quality of the process of Package C equivalence program and facilitate understanding even though learners learn independently.