bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative analysis of high-frequency radiometric databases. Application to the case of Seville
Authors: Pérez-Aparicio Elena , Moreno-Tejera Sara , Silva-Pérez Manuel A. , Lillo-Bravo Isidoro 
Published: October 2024

AbstractThe short-term variability of solar resource is one of the main challenges faced by the large-scale implementation of photovoltaic (PV) systems today; this will increase as the installed power of solar PV increases. To evaluate its influence on electrical grid operation, it is essential to analyse the variability of solar resource based on high-frequency data, 30 s and shorter. In this study, the high-frequency measurements of Global Horizontal Irradiation (GHI) and Direct Normal Irradiation (DNI) recorded every 5 s at the radiometric station of the University of Seville for 20 years are analysed and characterised. For this purpose, a corrected database for GHI and DNI was obtained from the application of a correction methodology. To understand the reliability of this database it is required to know its uncertainty. This work proposes a methodology to quantify the uncertainty of high-frequency radiometric databases whose wrong data have been corrected. Applying it, the daily uncertainty is 2.69% for GHI and 4.07% for DNI. To characterize the distribution of the database, the distribution of high frequency kt and kb indices are modelled providing the fitting parameters. To characterize the variability of high-frequency measurements, transition matrices are proposed, which allow identifying both the magnitude and frequency of jumps. The results obtained show that jumps of up to 800 W/m2 occur in both GHI and DNI. In the case of GHI, the percentage of jumps equal to or greater than 500 W/m2 is 1.36%, about 43,000 jumps in a year in measurements every 5 s.
Digital workflow to assess gingival recession coverage independently of the cemento-enamel Junction: a prospective clinical study using the modified coronally advanced tunnel technique with porcine dermal matrix
Authors: Iglhaut Gerhard , Fretwurst Tobias , Schulte Larissa , Sculean Anton , Vach Kirstin , Nelson Katja , Landwehr Victoria Constanze 
Published: October 2024

Abstract
Objectives
The limited number of studies using digital workflows to measure soft tissue changes depend on the cemento-enamel junction (CEJ), which has been reported to be unreliable. Our primary objective was to apply an advanced digital assessment method, measuring independent from the CEJ to evaluate the modified coronally advanced tunnel technique (MCAT) with a porcine dermal matrix (PDM) for gingival recession coverage.

Materials and methods
Patients with type RT1 and RT2 gingival recessions were treated with the MCAT and a PDM. Plaster casts (preoperative and 6 months postoperative) were digitalized. Subsequent stereolithography (STL)-files were imported and superimposed in the open-source software GOM Inspect for computer-based analysis. Recession depth, mean root and complete root coverage (mRC and cRC), mean recession reduction (mRR) and gingival thickness were evaluated. Statistical analysis was performed using mixed linear models.

Results
A total of 82 teeth (19 patients) were included in the study. Healing was uneventful in all patients. The mean preoperative recession depth was 1.34 ± 0.92 mm. mRC was 65.06 ± 48.26%, cRC was 25.61%, mRR was 0.87 ± 0.83 mm, and gingival thickness gain was 0.33 ± 0.30 mm, with comparable results for RT1 and RT2. Neither tooth type nor type of jaw had any effect on the amount of root coverage.

Conclusions
The digital evaluation workflow employed offers an approach to evaluate gingival recession coverage outcomes independent of the CEJ. The PDM used in combination with the MCAT shows promising results for root coverage.
Nailfold capillaroscopic assessment in pediatric patients with autoimmune uveitis: a case–control study
Authors: Abdelrahman Maha S. I. , Tohamy Dalia , Osman Naglaa S. , Saleh Mohamed G. A. 
Published: October 2024

AbstractUveitis is a major cause of visual impairment. Most uveitis cases have autoimmune etiology. Pediatric autoimmune uveitis may be associated with systemic diseases such as juvenile idiopathic arthritis or may arise as an isolated disorder. It may be accompanied by retinal vasculitis due to retinal microcirculation involvement. Nailfold capillaroscopy, a digital microscope, is a non-invasive tool for systemic microcirculation evaluation. We aimed to evaluate systemic microcirculation abnormalities in pediatric autoimmune uveitis. Twenty-five patients with pediatric autoimmune uveitis and 21 healthy children underwent detailed capillaroscopic evaluation. We assessed capillary density/mm, capillary morphology, capillary dimensions, and the presence or absence of microhemorrhages and avascular areas. The mean age of the study and control groups was 11.24 ± 3.03 and 9.9 ± 4.17 years, respectively. Most included patients had isolated uveitis and juvenile idiopathic arthritis (64% and 24%, respectively). The predominant uveitis subtype in the study was anterior uveitis (48%). A significant difference was found between cases and controls regarding mean capillary density (p-value = 0.0003) and the number of subjects having capillary density less than 7 (p-value = 0.002). Other capillaroscopic abnormalities did not show any significant difference between the studied groups. Mean capillary density did not correlate significantly with age, disease duration, or acute phase reactants. Children with autoimmune uveitis, whether isolated or as a part of systemic disease, may have systemic microcirculation involvement.

Key Points• Idiopathic autoimmune uveitis is not always an isolated intraocular condition.• Systemic microcirculation involvement may occur in pediatric autoimmune uveitis, even in cases with isolated uveitis.• Nailfold capillaroscopy showed that capillary density in children with autoimmune uveitis is significantly reduced compared to healthy controls.
Impact of prior knee surgery on change in knee pain, quality of life, and walking speed following supervised education and exercise therapy: an analysis of 30,545 people with knee osteoarthritis
Authors: Grønne Dorte T. , Sari Dilara M. , Skou Søren T. , Roos Ewa M. , Demirbüken Ilksan , Thorlund Jonas B. 
Published: October 2024

AbstractTo investigate the impact of prior knee surgery on changes in outcomes following an 8-week supervised patient education and exercise therapy program in patients with knee osteoarthritis. Patients were classified according to knee surgery in the most affected knee joint (yes/no) prior to enrolment in the Good Life with osteoArthritis in Denmark (GLA:D®) program. Between-group differences in outcome changes from baseline to 3 months follow-up were evaluated using linear regression stratified by sex. Outcomes were knee pain intensity (VAS, 0–100 mm), joint related quality of life (Knee Injury and Osteoarthritis Outcome Score Quality of Life subscale score (KOOS QOL, 0–100)) and walking speed (40-m fast-paced walk test). To evaluate clinically relevant between-group differences, proportions of patients reaching a threshold of minimal important change in the surgery and non-surgery groups were compared. Among 30,545 patients, 27% (n, 8254) had prior surgery in the most affected knee. The prior surgery and the non-surgery group experienced improvements in all outcomes with minor between-group differences in change in pain intensity (males, 0.03 95% CI − 0.9 to 1.0; females, 1.3 95% CI 0.6 to 2.1); KOOS QOL (males, 0.3 95% CI − 0.4 to 0.9; females 0.02 95% CI − 0.5 to 0.5); and walking speed (males, 0.01 95% CI − 0.01 to 0.02; females 0.01 95% CI 0.003 to 0.02). The responder analysis showed no clinically relevant between-group differences in improvements. Previous knee surgery does not seem to modify the clinical outcome following exercise therapy and patient education in patients with knee osteoarthritis.

Key Points

• About one in four patients with knee osteoarthritis participating in an 8-week supervised patient education and exercise therapy program had previous knee joint surgery in the most affected knee.• Those with prior knee surgery were more likely to be males, to have prior knee injury, to have a longer symptom duration, and to have a high physical activity level compared to those without previous knee surgery.• Patients with prior knee surgery did not experience clinically relevant less change in knee pain, joint related quality of life, and walking speed after participation in the intervention, compared to those without previous knee surgery.• Patients with previous knee surgery can expect clinical outcomes following exercise therapy and patient education similar to patients without prior knee joint surgery.
Dynamic nuclear polarization solid-state NMR spectroscopy as a tool to rapidly determine degree of modification in dialcohol cellulose
Authors: Karlsson Hampus , Svenningsson Leo , Storm Robin , Chaiyupatham Poppy , Brolin Anders , Larsson Anette , Pinon Arthur C. , Schantz Staffan , Karlson Leif , Larsson Per A. , Evenäs Lars 
Published: October 2024

AbstractDialcohol cellulose can be prepared by periodate-mediated oxidation of cellulose followed by reduction with borohydride. The two-step reaction creates a modified cellulose polymer which is ring-opened between the C2 and C3 carbons in the glucose unit. This material has attracted both scientific and commercial interest, due to its potential role in the transition towards a fossil-fuel-free society. In order to become a reliable component in the materials of tomorrow, chemical properties such as degree of modification must be accurately quantified. In this work we describe how solid-state NMR spectroscopy, enhanced by dynamic nuclear polarization (DNP), can be used for this purpose. Our results illustrate that it is possible to obtain high sensitivity enhancements in dialcohol cellulose with the DNP enhanced solid-state NMR technique. Enhancements above a factor of fifty, on a 400 MHz/263 GHz DNP system in the presence of 12 mM AMUPol radical were achieved. This allows us to quantify the degree of modification in dialcohol cellulose samples in time spans as short as 20 min using DNP enhanced multiple-contact cross polarization experiments. We also exemplify how DNP enhanced, 13C-13C dipolar recoupling experiments can be used for the same purpose and for studying chemical shift correlations in dialcohol cellulose.
Graphical abstract
Genetic Variability in Oxidative Stress, Inflammatory, and Neurodevelopmental Pathways: Impact on the Susceptibility and Course of Spinal Muscular Atrophy
Authors: Barbo Maruša , Koritnik Blaž , Leonardis Lea , Blagus Tanja , Dolžan Vita , Ravnik-Glavač Metka 
Published: October 2024

AbstractThe spinal muscular atrophy (SMA) phenotype strongly correlates with the SMN2 gene copy number. However, the severity and progression of the disease vary widely even among affected individuals with identical copy numbers. This study aimed to investigate the impact of genetic variability in oxidative stress, inflammatory, and neurodevelopmental pathways on SMA susceptibility and clinical progression. Genotyping for 31 genetic variants across 20 genes was conducted in 54 SMA patients and 163 healthy controls. Our results revealed associations between specific polymorphisms and SMA susceptibility, disease type, age at symptom onset, and motor and respiratory function. Notably, the TNF rs1800629 and BDNF rs6265 polymorphisms demonstrated a protective effect against SMA susceptibility, whereas the IL6 rs1800795 was associated with an increased risk. The polymorphisms CARD8 rs2043211 and BDNF rs6265 were associated with SMA type, while SOD2 rs4880, CAT rs1001179, and MIR146A rs2910164 were associated with age at onset of symptoms after adjustment for clinical parameters. In addition, GPX1 rs1050450 and HMOX1 rs2071747 were associated with motor function scores and lung function scores, while MIR146A rs2910164, NOTCH rs367398 SNPs, and GSTM1 deletion were associated with motor and upper limb function scores, and BDNF rs6265 was associated with lung function scores after adjustment. These findings emphasize the potential of genetic variability in oxidative stress, inflammatory processes, and neurodevelopmental pathways to elucidate the complex course of SMA. Further exploration of these pathways offers a promising avenue for developing personalized therapeutic strategies for SMA patients.
Distrust and reflexive impotence in the net zero transition: findings from a longitudinal deliberative mini-public
Authors: Ainscough Jacob , Lewis Pancho , Farrow Lucy 
Published: October 2024

AbstractResponding to climate change requires that people engage in different forms of climate citizenship. These span from individual consumption choices, to taking part in forms of collective action to steer the behaviour of governments and in the private sector. Here we analyse data from the Net Zero Diaries project to explore how attitudes to different forms of climate citizenship develop as people become more aware about the scale of societal change required to reach net zero carbon emissions by 2050. The Net Zero Diaries project was a deliberative mini-public, composed of 41 citizens broadly representative of the UK adult population, which convened over five months between 2021 and 2022 to debate the UK policies for reaching net zero emissions by 2050. We show that people identify government as the prime actor needed to drive the transition, but doubt that they will act due to a range of constraints vis-à-vis the public and private sector. This tension provides a novel explanation for why some people prioritise forms of individual and consumption focused climate citizenship, whilst also doubting the efficacy of such actions. We conclude by suggesting that efforts to drive more engaged forms of climate citizenship need to attend to underlying feelings about state efficacy, rather than focus on just how the issue of climate change is framed.
Are Mathematics and Writing Skills Related? Evidence from Meta-Analysis
Authors: Kim Young-Suk Grace , Yang Dandan , Hwang Jinkyung 
Published: October 2024

AbstractWriting and mathematics are essential in academic achievement. In the present study, we investigated whether writing skills and mathematics skills are related and if so, whether their relation is moderated by participants’ grade level (a proxy for developmental phase), subskills of mathematics and writing skills, and assessment characteristics (normed and standardized nature of mathematics and writing tasks, and reliability of mathematics and writing measures), using a meta-analysis. A total of 211 studies (k = 564, N = 1,207,983) met inclusion criteria. Overall, mathematics and writing were moderately related (r = .48). The overall magnitude of their relation differed as a function of grade level such that the relation was stronger for students in primary grade levels compared to those in university and above. When explored by higher order and lower order writing and mathematics skills and grade levels, lower order writing and mathematics (.59) and higher order writing and mathematics (.48) had substantial relations in primary grades, whereas higher order writing and mathematics were weakly related in adulthood (.25). The relation also differed by the reliability of mathematics tasks such that the magnitude was stronger for mathematics tasks with higher reliability. For writing, the relation was stronger for writing tasks that were normed and standardized compared to those that were not. These results confirm not only a mathematics–writing relation but also factors that influence this relation. Future work is warranted to investigate mechanisms of the relation and potential practical implications.
Mercury speciation in environmental samples associated with artisanal small-scale gold mines using a novel solid-phase extraction approach to sample collection and preservation
Authors: King David , Watts Michael , Hamilton Elliott , Mortimer Robert , Coffey Michael , Osano Odipo , Di Bonito Marcello 
Published: October 2024

AbstractIn artisanal small-scale gold mines (ASGM), mercury (Hg) is known to pollute nearby river waters and sediments where it can be methylated to the highly bioavailable methylmercury (MeHg). The assessment of Hg speciation in water samples has been challenging for many years, with recommended procedures often not adequately allowing for analysis of samples in a suitable timeframe. Using a novel solid-phase extraction (SPE) method for sampling and preservation of Hg species, representative speciation data can be safely and easily collected and retained for up to 4-weeks (MeHg = 115 ± 8% refrigerated and 109 ± 13% unrefrigerated storage; Hg2+  = 100 ± 14% refrigerated and 94 ± 12% unrefrigerated storage). Concentrations of MeHg in environmental water samples and drinking water were below detection limit across two ASGM sites in western Kenya and concentrations of Hg2+ were below drinking water guidelines; however, drinking water sources contribute 20–30% of the tolerable weekly intake of Hg, indicating a need to minimise exposure of Hg from dietary sources to prevent Hg poisoning. Sediments from receiving rivers at ASGM sites showed total Hg concentrations above guideline limits (0.08–1.84 mg kg−1 total Hg) along the length of the river; however, MeHg concentrations fluctuated dependent on the stagnation of the river due to damns and ponds (5.9 ± 14.3 µg kg−1 MeHg). The findings show that SPE can be used as a robust sample collection and preservation approach for Hg speciation, which can better inform mitigation measures, understand ecological and human health implications, and improve environmental monitoring.
Psychometric Properties of the Chinese Version of the Psy-Flex Among Parents of Children with Autism Spectrum Disorder
Authors: Li Si Ni , Chien Wai Tong , Lam Stanley Kam Ki , Chong Yuen Yu , Gloster Andrew T. 
Published: October 2024

AbstractThis research aimed to translate the original English version of the Psy-Flex, a scale of psychological flexibility, into Chinese and to test its psychometric properties among parents of children with autism spectrum disorder (ASD). Two phases were conducted: (1) translation from English to Chinese (Psy-Flex-C), followed by a semantic equivalence evaluation between two versions, a pre-test, and an evaluation of the Psy-Flex-C in terms of face validity with 20 parents of autistic children, and content validity of the Psy-Flex-C with eight experts. (2) A cross-sectional study with 248 parents of autistic children was conducted for validation, and a subgroup of 50 participants was randomly selected to assess the test–retest reliability at a 2-week interval. The Psy-Flex-C showed satisfactory semantic equivalence with the original version and demonstrated adequate internal consistency (Cronbach’s α = 0.84) and test–retest stability (weighted kappa statistic = 0.88). Concurrent validity was supported by a moderate correlation between the Psy-Flex-C and the Comprehensive Assessment of Acceptance and Commitment Therapy Processes (Pearson’s r = 0.54, p < 0.01). The Psy-Flex-C showed a significant mean score difference between parents with high and low parenting stress (t = 5.43, p < 0.001). Similar to the original scale, confirmatory factor analysis showed the best fitting one-factor structure of the Psy-Flex-C (X2/df = 1.62, p = 0.13, RMSEA = 0.05, GFI = 0.99, CFI = 0.99, TLI = 0.98, SRMR = 0.023). The Psy-Flex-C can be a reliable and valid instrument to self-report psychological flexibility in parents of children with ASD. Future research is recommended to test the Psy-Flex-C using diverse samples from different cultures and contexts to enhance its generalizability.
The state role in the housing sector in Hamburg and Havana challenges and successes of the state's claim to control in different political and planning systems
Authors: Santana Caraballo Angel Junior , ElGamal Mohamed , Dobal Fonseca Dachelis , Anders Sascha , Rúa de Cabo Arturo , Altrock Uwe , Arjona Cisneros Yaima 
Published: October 2024

AbstractHousing supply is a controversial topic across the globe. In Europe, for example, housing provision is fundamentally characterised by capitalist market economy. However, the intensity of state intervention differs significantly in the respective European countries. Germany is certainly one of the countries in which the state traditionally intervenes considerably in the housing market and attempts to control it through various measures. In addition, the stakeholders in the housing market are very different, and the housing market is highly segmented. In Cuba, as a rather atypical example for Latin America, where the housing market is largely liberalised, the housing market is very strongly regulated by the socialist Cuban state. In this article, we address the topics of housing supply by analysing the institutional framework conditions and the different levels of intervention in the very different systems of Germany and Cuba. In doing so, we find that the objectives at the planning and political levels in these two case studies are quite similar despite the major political and social differences. It has become clear, that there is a gap between the aspiration of the political-administrative planning system and the planning expectations of the citizens in both systems. However, it is also emphasised that the state's claim to intervene in the housing market and the regulations, production and financing conditions are very different. Using Vaus’s ‘most-different-case approach’, we emphasise for the two cities of Hamburg and Havana that although considerable successes have been achieved in both systems in terms of adequate housing provision, but major challenges still exist in both cities. The analysis has also made clear how important it is to combine housing policy demands with the realities of housing industry, real estate markets and urban planning perspectives.
An Artificial Intelligent System for Prostate Cancer Diagnosis in Whole Slide Images
Authors: Saha Sajib , Vignarajan Janardhan , Flesch Adam , Jelinko Patrik , Gorog Petra , Szep Eniko , Toth Csaba , Gombas Peter , Schvarcz Tibor , Mihaly Orsolya , Kapin Marianna , Zub Alexandra , Kuthi Levente , Tiszlavicz Laszlo , Glasz Tibor , Frost Shaun 
Published: October 2024

Abstract
In recent years a significant demand to develop computer-assisted diagnostic tools to assess prostate cancer using whole slide images has been observed. In this study we develop and validate a machine learning system for cancer assessment, inclusive of detection of perineural invasion and measurement of cancer portion to meet clinical reporting needs. The system analyses the whole slide image in three consecutive stages: tissue detection, classification, and slide level analysis. The whole slide image is divided into smaller regions (patches). The tissue detection stage relies upon traditional machine learning to identify WSI patches containing tissue, which are then further assessed at the classification stage where deep learning algorithms are employed to detect and classify cancer tissue. At the slide level analysis stage, entire slide level information is generated by aggregating all the patch level information of the slide. A total of 2340 haematoxylin and eosin stained slides were used to train and validate the system. A medical team consisting of 11 board certified pathologists with prostatic pathology subspeciality competences working independently in 4 different medical centres performed the annotations. Pixel-level annotation based on an agreed set of 10 annotation terms, determined based on medical relevance and prevalence, was created by the team. The system achieved an accuracy of 99.53% in tissue detection, with sensitivity and specificity respectively of 99.78% and 99.12%. The system achieved an accuracy of 92.80% in classifying tissue terms, with sensitivity and specificity respectively 92.61% and 99.25%, when 5x magnification level was used. For 10x magnification, these values were respectively 91.04%, 90.49%, and 99.07%. For 20x magnification they were 84.71%, 83.95%, 90.13%.