bluuebunny/crossref_metadata_2025_split huggingface dataset:
The PRMT7-dependent methylation of shank2 modulates invasion-proliferation switching during breast cancer metastasis
Authors: Liu Yingqi , Liu Xiaoqing , Liu Lingxia , Wang Yibo , Peng Lu , Liu Jiayuan , Li Lingling , Zhang Lian , Wang Guannan , Li Honghuan , Liu Dongxu , Huang Baiqu , Lu Jun , Zhang Yu 
Published: August 2019

AbstractInvasiveness of cancer cells is associated with proliferation inhibition in multiple types of cancers. Here, we identified the pivotal roles of Arginine methyltransferase PRMT7 in promoting invasion and attenuating proliferation of breast cancer cells. PRMT7 exerted its functions through binding to the scaffold protein shank2 to induce the di-methylation of shank2 at R240. Shank2 R240 methylation exposed ANK domain by disrupting its SPN-ANK domain blockade. Moreover, shank2 R240 methylation rendered recruitment of FAK that elicited the FAK auto-phosphorylation, which consequently augmented the shank2-dependent migration and invasion of breast cancer cells. On the other hand, the shank2 R240 methylation impeded proliferation of breast cancer cells by antagonizing the Ras-Raf binding via tethering the mono-ubiquitinated H-Ras. These findings characterize the PRMT7-dependent shank2 methylation as a key player in mediating reciprocal switching between invasion and proliferation, also point to the value of shank2 R240 methylation as a target for tumour metastasis treatment strategies.
The Gene Expression Deconvolution Interactive Tool (GEDIT): Accurate Cell Type Quantification from Gene Expression Data
Authors: Nadel Brian B. , Lopez David , Montoya Dennis J. , Ma Feiyang , Waddel Hannah , Khan Misha M. , Mangul Serghei , Pellegrini Matteo 
Published: August 2019

AbstractThe cell type composition of heterogeneous tissue samples can be a critical variable in both clinical and laboratory settings. However, current experimental methods of cell type quantification (e.g. cell flow cytometry) are costly, time consuming, and can introduce bias. Computational approaches that infer cell type abundance from expression data offer an alternate solution. While these methods have gained popularity, most are limited to predicting hematopoietic cell types and do not produce accurate predictions for stromal cell types. Many of these methods are also limited to particular platforms, whether RNA-seq or specific microarrays. We present the Gene Expression Deconvolution Interactive Tool (GEDIT), a tool that overcomes these limitations, compares favorably with existing methods, and provides superior versatility. Using both simulated and experimental data, we extensively evaluate the performance of GEDIT and demonstrate that it returns robust results under a wide variety of conditions. These conditions include a variety of platforms (microarray and RNA-seq), tissue types (blood and stromal), and species (human and mouse). Finally, we provide reference data from eight sources spanning a wide variety of stromal and hematopoietic types in both human and mouse. This reference database allows the user to obtain estimates for a wide variety of tissue samples without having to provide their own data. GEDIT also accepts user submitted reference data, thus allowing the estimation of any cell type or subtype, provided that reference data is available.Author SummaryThe Gene Expression Deconvolution Interactive Tool (GEDIT) is a robust and accurate tool that uses gene expression data to estimate cell type abundances. Extensive testing on a variety of tissue types and technological platforms demonstrates that GEDIT provides greater versatility than other cell type deconvolution tools. GEDIT utilizes reference data describing the expression profile of purified cell types, and we provide in the software package a library of reference matrices from various sources. GEDIT is also flexible and allows the user to supply custom reference matrices. A GUI interface for GEDIT is available at http://webtools.mcdb.ucla.edu/, and source code and reference matrices are available at https://github.com/BNadel/GEDIT.
When two mindfulnesses meet
Authors: Lakatos Louis , Turcotte Josée , Oddson Bruce 
Published: August 2019

AbstractThe study of mindfulness proceeds from a number of perspectives. Two of the best-known academic conceptualizations of mindfulness are those identified with Kabat-Zinn and Langer. These conceptions, meditative and socio-cognitive, have been built from different foundations and have been argued to be quite distinct. However, Hart, Ivtzan and Hart1suggested that self-regulation of attention is a mediator between the two. To put this hypothesis to a test, a convenience sample of participants (n = 208) were asked to complete the Five Facet Mindfulness Questionnaire (FFMQ), Langer Mindfulness Scale (LMS), and the Self-Regulation Scale (SRS), a measure of the self-regulation of attention. These three dispositional measures were shown to be correlated. Self-regulation passes a statistical test for partial mediation of the relationship between the two measures of mindfulness. This suggests that reliance on the capacity to regulate attention in pursuit of a goal is shared by these two approaches to mindfulness. However, there is no clear conceptual basis for mediation in either particular direction. Further, the correlation between the LMS and FFMQ is highest for those with the highest SRS scores; we discuss the implications for conceptual distinctions within mindfulness.
Rapid computation of rotary derivatives for subsonic and low transonic flows
Authors: Fu Jian-Ming , Tang Hai-Min , Chen Hong-Quan 
Published: August 2019

Purpose
The purpose of this paper is to develop a new approach for rapid computation of subsonic and low-transonic rotary derivatives with the available steady solutions obtained by Euler computational fluid dynamics (CFD) codes.

Design/methodology/approach
The approach is achieved by the perturbation on the steady-state pressure of Euler CFD codes. The resulting perturbation relation is established at a reference Mach number between rotary derivatives and normal velocity on surface due to angular velocity. The solution of the reference Mach number is generated technically by Prandtl–Glauert compressibility correction based on any Mach number of interest under the assumption of simple strip theory. Rotary derivatives of any Mach number of interest are then inversely predicted by the Prandtl–Glauert rule based on the reference Mach number aforementioned.

Findings
The resulting method has been verified for three typical different cases of the Basic Finner Reference Projectile, the Standard Dynamics Model Aircraft and the Orion Crew Module. In comparison with the original perturbation method, the performance at subsonic and low-transonic Mach numbers has significantly improved with satisfactory accuracy for most design efforts.

Originality/value
The approach presented is verified to be an efficient way for computation of subsonic and low-transonic rotary derivatives, which are performed almost at the same time as an accounting solution of steady Euler equations.
A formulation of membrane finite elements with true drilling rotation
Authors: Boutagouga Djamel 
Published: August 2019

Purpose
This paper aims to describe the formulation of a displacement-based triangular membrane finite element with true drilling rotational degree of freedom (DOF).

Design/methodology/approach
The presented formulation incorporates the true drilling rotation provided by continuum mechanics into the displacement field by way of using the polynomial interpolation. Unlike the linked interpolation, that uses a geometric transformation between displacement and vertex rotations, in this work, the interpolation of the displacement field in terms of nodal drilling rotations is obtained following an unusual approach that does not imply any presumed geometric transformation.

Findings
New relationship linking the mid-side normal displacement to corner node drilling rotations is derived. The resulting new element with true drilling rotation is compatible and does not include any problem-dependent parameter that may influence the results. The spurious zero-energy mode is stabilized in a careful way that preserves the true drilling rotational degrees of freedom (DOFs).

Originality/value
Several works dealing with membrane elements with vertex rotational DOFs have been published with improved convergence rate, however, owing to the need for incorporating rotations in the finite element meshes involving solids, shells and beam elements, having finite elements with true drilling rotational DOFs is more appreciated.
A global sensitivity analysis-assisted sequential optimization tool for plant-fin heat sink design
Authors: Li Enying , Zhou Zheng , Wang Hu , Cai Kang 
Published: August 2019

Purpose
This study aims to suggest and develops a global sensitivity analysis-assisted multi-level sequential optimization method for the heat transfer problem.

Design/methodology/approach
Compared with other surrogate-assisted optimization methods, the distinctive characteristic of the suggested method is to decompose the original problem into several layers according to the global sensitivity index. The optimization starts with the several most important design variables by the support vector regression-based efficient global optimization method. Then, when the optimization process progresses, the filtered design variables should be involved in optimization one by one or the setting value. Therefore, in each layer, the design space should be reduced according to the previous optimization result. To improve the accuracy of the global sensitivity index, a novel global sensitivity analysis method based on the variance-based method incorporating a random sampling high-dimensional model representation is introduced.

Findings
The advantage of this method lies in its capability to solve complicated problems with a limited number of sample points. Moreover, to enhance the reliability of optimum, the support vector regression-based global efficient optimization is used to optimize in each layer.

Practical implications
The developed optimization tool is built by MATLAB and can be integrated by commercial software, such as ABAQUS and COMSOL. Lastly, this tool is integrated with COMSOL and applied to the plant-fin heat sink design. Compared with the initial temperature, the temperature after design is over 49°. Moreover, the relationships among all design variables are also disclosed clearly.

Originality/value
The D-MORPH-HDMR is integrated to obtain the coupling relativities among the design variables efficiently. The suggested method can be decomposed into multiplier layers according to the GSI. The SVR-EGO is used to optimize the sub-problem because of its robustness of modeling.
Towards a contingent approach to firm strategy on the lowest levels of the hierarchy of the defence industry
Authors: Vicente Oliva Silvia , Martínez-Sánchez Ángel , Escribano-Bernal Francisco 
Published: August 2019

Purpose
This paper aims to provide a strategic analysis of firms at the lowest hierarchical levels of the defence industry.

Design/methodology/approach
This paper presents the main results of an exploratory, multiple-case study that analyses the current strategy drivers and their views about the future ones, and their impact at the lowest hierarchical levels of the defence industry in Spain.

Findings
This investigation develops and analyses a contingency model regarding the strategy impact and effects of firms’ drivers and clients, both mediated by the strategy players because of their huge impact on the defence industry. The research model focuses on the internal relations between technical and commercial activities due to the cause and effect of their capabilities. Simultaneously, pull and push mechanisms boost firms’ capabilities and requirements to provide strategic foresight.

Practical implications
Ministries of Defence (MoDs) and prime contractors will remain mediating players in the near future even with further implications for the competition of Defence Technological and Industrial Base (DTIB) firms. It implies that firms and MoDs must maintain a close relation and implement more flexible practices, such as open innovation, property rights or new commercialization schemes.

Originality/value
This study offers insights related to the specific applications and the necessity of commercial and technological areas alignment of these firms for the future.
Methodological evaluation of Integrated Façade Systems
Authors: Ibraheem Yahya , Piroozfar Poorang A.E. , Farr Eric R.P. , Ravenscroft Neil 
Published: August 2019

Purpose
The purpose of this paper is to develop a methodology to test the robustness of energy performance of highly to fully glazed office buildings in hot and arid climates using the net energy figures.

Design/methodology/approach
The paper uses a methodology to develop a base-case model for building energy simulation (BES) of highly to fully glazed office buildings followed by sensitivity analysis (linear regression model) to test the robustness of the results.

Findings
Net energy is best achieved on south, followed by southeast, and southwest façadesof the bulding; the increase in d/l ratio has a diverse effect, while there is a significant influence of glazing systems on the resultant net energy figures.

Research limitations/implications
The lack of experimental data for Integrated Façade System (IFS) with its various applications in the existing body of knowledge forms the main limitation of this research.

Practical implications
Findings can be of practical use to practitioners and academics to assist them as a decision tool when working on the energy performance of IFS.

Social implications
The research contributes to energy consumption reduction in office building stock at peak times, lowering the consequent energy shortage and blackouts for non-office buildings with clear positive social impacts.

Originality/value
Adopting a systemic approach in BES studies will help further the understanding on the impact of some phenomena and justify how the contributory parameters would behave when combined effects are under investigations.
Modeling of chloride penetration in concrete structures under freeze-thaw cycles
Authors: Hamidane H’mida , Ababneh Ayman , Messabhia Ali , Xi Yunping 
Published: August 2019

Purpose
The purpose of this paper is to develop a method for predicting the chloride ingress into concrete structures, with an emphasis on the low temperature range where freeze-thaw cycles may cause damage.

Design/methodology/approach
The different phenomena that contribute to the rate and amount of transported chlorides into concrete, i.e., heat transfer, moisture transport and chloride diffusion are modeled using a two-dimensional nonlinear time dependent finite element method. In modeling the chloride transport, a modified version of Fick’s second law is used, in which processes of diffusion and convection due to water movement are taken into account. Besides, the effect of freeze-thaw cycles is directly incorporated in the governing equation and linked to temperature variation using a coupling term that is determined in this study. The proposed finite element model and its associated program are capable of handling pertinent material nonlinearities and variable boundary conditions that simulate real exposure situations.

Findings
The numerical performance of the model was examined through few examples to investigate its ability to simulate chloride penetration under freeze-thaw cycles and its sensitivity to factors controlling freeze-thaw damage. It was also proved that yearly temperature variation models to be used in service life assessment should take into account its cyclic nature to obtain realistic predictions.

Originality/value
The model proved promising and suitable for chloride penetration in cold climates.
A framework for reconstruction of road infrastructure after a disaster
Authors: Hayat Ezri , Haigh Richard , Amaratunga Dilanthi 
Published: August 2019

Purpose
This paper aims to identify the main aspects requiring immediate attention in the post-disaster reconstruction of road infrastructure, thereby providing a major synthesis, which advances the understanding in this important area.

Design/methodology/approach
Literature and empirical evidence obtained from documents and semi-structured interviews with 28 respondents of three case study districts in Aceh, Indonesia was analysed using NVivo 10. The findings were validated through triangulation with the literature and consultation with the experts in the field of disaster management and road infrastructure.

Findings
The authors propose a framework for the reconstruction of road infrastructure, which respond to the peculiarities of road projects in a post-disaster setting. The framework comprises various components requiring detailed attention in the reconstruction process and describes their position in the road project and disaster management cycle.

Originality/value
The framework fills the gap in the body of knowledge with regard to road infrastructure reconstruction in a post-disaster context. For the first time, this paper recognises the importance of local government capacity in the Aceh Province with regard to the sustainability of the post-disaster reconstruction assets.
Evaluating the performance of auditors: a driver or a stabilizer of auditors’ behaviour
Authors: Nehme Rabih , AlKhoury Christelle , Al Mutawa Abdullah 
Published: August 2019

Purpose
The purpose of this paper is to identify differences in auditors’ dysfunctional behaviour when expecting performance appraisal. Its main aim is to examine variances across countries; UK vs Kuwait. Also, it identifies differences between experienced and inexperienced auditors.

Design/methodology/approach
The paper focuses on dysfunctional audit behaviour (DAB) where premature sign-off and under-reporting of chargeable time are chosen as the two main signalling proxies. A survey made up of statements included in performance appraisal templates is distributed among auditors working for the Big Four firms in both, the UK and Kuwait.

Findings
The paper shows how performance evaluation of external auditors affects their behaviour in the workplace. From a cultural standpoint, assessing the performance of auditors whilst working in a competitive market in a developed country is regarded as a potential driver for DAB variations. Evaluating auditors’ performance in a developing country is seen as a stabiliser of DAB. This research paper demonstrates that experienced auditors have a greater tendency to behave dysfunctionally as compared to inexperienced auditors.

Originality/value
Prior studies have been conducted to assess auditors’ performance through using internal and external attributes (Kaplan, 1985), offshoring basic steps of audit work (Downey, 2018), and the perception of audit clients about auditors’ performance (Reheul et al., 2013). Such studies were conducted mostly on developed countries on a standalone basis. In this study, the focus has been shifted from focusing on one country to comparing two different countries. The paper examines DAB between experienced and inexperienced auditors in the UK and in Kuwait when expecting performance evaluation.
Online social network security awareness: mass interpersonal persuasion using a Facebook app
Authors: Ikhalia Ehinome , Serrano Alan , Bell David , Louvieris Panos 
Published: August 2019

Purpose
Online social network (OSN) users have a high propensity to malware threats due to the trust and persuasive factors that underpin OSN models. The escalation of social engineering malware encourages a growing demand for end-user security awareness measures. The purpose of this paper is to take the theoretical cybersecurity awareness model TTAT-MIP and test its feasibility via a Facebook app, namely social network criminal (SNC).

Design/methodology/approach
The research employs a mixed-methods approach to evaluate the SNC app. A system usability scale measures the usability of SNC. Paired samples t-tests were administered to 40 participants to measure security awareness – before and after the intervention. Finally, 20 semi-structured interviews were deployed to obtain qualitative data about the usefulness of the App itself.

Findings
Results validate the effectiveness of OSN apps utilising a TTAT-MIP model – specifically the mass interpersonal persuasion (MIP) attributes. Using TTAT-MIP as a guidance, practitioners can develop security awareness systems that better leverage the intra-relationship model of OSNs.

Research limitations/implications
The primary limitation of this study is the experimental settings. Although the results testing the TTAT-MIP Facebook app are promising, these were set under experimental conditions.

Practical implications
SNC enable persuasive security behaviour amongst employees and avoid potential malware threats. SNC support consistent security awareness practices by the regular identification of new threats which may inspire the creation of new security awareness videos.

Social implications
The structure of OSNs is making it easier for malicious users to carry out their activities without the possibility of detection. By building a security awareness programme using the TTAT-MIP model, organisations can proactively manage security awareness.

Originality/value
Many security systems are cumbersome, inconsistent and non-specific. The outcome of this research provides organisations and security practitioners with a framework for designing and developing proactive and tailored security awareness systems.
Peer support on the “inside and outside”: building lives and reducing recidivism for people with mental illness returning from jail
Authors: Bellamy Chyrell , Kimmel James , Costa Mark N. , Tsai Jack , Nulton Larry , Nulton Elissa , Kimmel Alexandra , Aguilar Nathan J. , Clayton Ashley , O’Connell Maria 
Published: August 2019

Purpose
The purpose of this paper is to gain understanding about the effectiveness of a forensic peer support program’s impact on reducing criminal recidivism. People with histories of mental illness returning to the community following incarceration face tremendous challenges in jails and prisons and in successful reentry to community. Transitioning from jails and prisons is fraught with additional challenges such as reconnecting or connecting with mental health and substance abuse treatment, finding adequate housing, finding employment, reuniting with family and friends, etc. Unfortunately, recidivism remains high, principally because of these challenges. Many state and local authorities have supported the development of the forensic peer specialist.

Design/methodology/approach
Kaplan–Meier survival analyses were conducted to examine time to re-incarceration.

Findings
The population served was determined to be a particularly high risk of re-incarceration population, when released from prison. All had a mental illness diagnosis, with 80 percent diagnosed with at least one serious mental illness, and more than 50 percent had three or more anterior incarcerations. Utilizing Kaplan–Meyer survival analysis, the chance of re-incarceration for participants after one year was of 21.7 percent. Surprisingly, in the first year after release from prison, participants did much better than those in the general US prison population when in terms of re-incarceration rates (21.7 percent vs 43.4 percent).

Originality/value
While preliminary findings of this approach, this study reaffirms the idea that forensic peer support programs are beneficial in reducing recidivism rates for people diagnosed with a mental illness coming out of prison, offering individuals supports to maintain their lives in the community.