bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does social interaction influence the effect of cognitive intervention program? A randomized controlled trial using Go game
Authors: Iizuka Ai , Suzuki Hiroyuki , Ogawa Susumu , Kobayashi‐Cuya Kimi Estela , Kobayashi Momoko , Inagaki Hiroki , Sugiyama Mika , Awata Shuichi , Takebayashi Toru , Fujiwara Yoshinori 
Published: November 2018

ObjectivesThe purpose of this study is to clarify the influence of social interaction on the effect of a cognitive intervention program using Go.MethodsA single‐blind, randomized controlled trial using a classical board game “Go” was conducted. A total of 72 community‐dwelling older adults, without previous experience playing Go, were randomly assigned to three groups: (1) a face‐to‐face group (FG) in which members attended 12 Go group lessons held once a week; (2) a non‐face‐to‐face group (NFG) in which members individually underwent the same Go lessons as the FG using a tablet computer; or (3) a health education control group (CG). The main outcome variable, working memory, was assessed before and after the interventions using the Visual Memory Span Test (VMST) and the Visual Memory Span Backward (VMSB) task. Go performance and additional cognitive domains were also examined.ResultsAnalysis of covariance revealed that VMST scores significantly improved after the intervention in both the FG and NFG (both P < .05). Compared with the CG, the effect size of the FG (Cohen's d = 0.89) was greater than that of the NFG (Cohen's d = 0.67). Although VMSB scores significantly improved after the intervention in the FG (P < .05), no significant changes were observed in other groups.ConclusionsThis study showed that Go game could improve visual working memory regardless of social interaction. Furthermore, findings suggested that playing board games face‐to‐face with others is more effective for cognitive function than playing alone.
Metabolic syndrome rates in older patients with severe mental illness after five years of follow‐up and the association with mortality
Authors: de Louw Emma J. , Paans Nadine P.G. , Sonnenberg Caroline M. , Konz Hugo , Meesters Paul D. , van Grootheest Daniel , Oudega Mardien L. , Rhebergen Didi , Kerssens Cora , Comijs Hannie C. , Stek Max L. , Dols Annemiek 
Published: November 2018

ObjectivesTo establish the course of metabolic syndrome (MS) rates in older patients with severe mental illness (SMI) after 5‐year follow‐up and evaluate whether MS at baseline is associated with mortality or diabetes at follow‐up.MethodsPatients (>60 years of age) with SMI (N = 100) were included at a specialized mental health outpatient clinic. Metabolic parameters were collected from patients' medical files at baseline and after 5‐year follow‐up.ResultsFollow‐up data were available of 98 patients (98%); nine patients had died. Parameters of MS were available of 76 patients; 34.2% were diagnosed with MS. This was not significantly different compared with baseline (46.1%). MS at baseline was not significantly associated with mortality or development of diabetes at follow‐up.ConclusionsIn older patients with SMI, the rates of MS may reach a plateau. Screening for MS in older patients treated at a specialized mental health outpatient clinic may generate attention for their somatic health and treatment for the components of MS that may in turn have a positive effect on their outcome. However, further research with larger sample sizes is needed in order to confirm these findings.
The recency ratio is related to CSF amyloid beta 1‐42 levels in MCI‐AD
Authors: Bruno Davide , Gleason Carey E. , Koscik Rebecca L. , Pomara Nunzio , Zetterberg Henrik , Blennow Kaj , Johnson Sterling C. 
Published: November 2018

ObjectiveAs anti‐amyloid therapeutic interventions shift from enrolling patients with Alzheimer's disease (AD) dementia to individuals with pre‐clinical disease, the need for sensitive measures that allow for non‐invasive, fast, disseminable, and cost‐effective identification of preclinical status increases in importance. The recency ratio (Rr) is a memory measure that relies on analysis of serial position performance, which has been found to predict cognitive decline and conversion to early mild cognitive impairment (MCI). The aim of this study was to test Rr's sensitivity to cerebrospinal fluid (CSF) levels of the core AD biomarkers in individuals with MCI‐AD and controls.MethodsBaseline data from 126 (110 controls and 16 MCI‐AD) participants from the Wisconsin Alzheimer's Disease Research Center were analysed. Partial correlations adjusting for demographics were carried out between CSF measure of amyloid beta (Aβ40, Aβ42, and the 40/42 ratio) and tau (total and phosphorylated), and memory measures (Rr, delayed recall, and total recall) derived from the Rey's Auditory Verbal Learning Test.ResultsResults indicated that Rr was the most sensitive memory score to Aβ42 levels in MCI‐AD, while no memory score correlated significantly with any biomarker in controls.ConclusionsThis study shows that Rr is a sensitive cognitive index of underlying amyloid β pathology in MCI‐AD.
Gradual acquisition of visuospatial associative memory representations via the dorsal precuneus
Authors: Schott Björn H. , Wüstenberg Torsten , Lücke Eva , Pohl Ina‐Maria , Richter Anni , Seidenbecher Constanze I. , Pollmann Stefan , Kizilirmak Jasmin M. , Richardson‐Klavehn Alan 
Published: November 2018

AbstractActivation of parietal cortex structures like the precuneus is commonly observed during explicit memory retrieval, but the role of parietal cortices in encoding has only recently been appreciated and is still poorly understood. Considering the importance of the precuneus in human visual attention and imagery, we aimed to assess a potential role for the precuneus in the encoding of visuospatial representations into long‐term memory. We therefore investigated the acquisition of constant versus repeatedly shuffled configurations of icons on background images over five subsequent days in 32 young, healthy volunteers. Functional magnetic resonance imaging was conducted on Days 1, 2, and 5, and persistent memory traces were assessed by a delayed memory test after another 5 days. Constant compared to shuffled configurations were associated with significant improvement of position recognition from Day 1 to 5 and better delayed memory performance. Bilateral dorsal precuneus activations separated constant from shuffled configurations from Day 2 onward, and coactivation of the precuneus and hippocampus dissociated recognized and forgotten configurations, irrespective of condition. Furthermore, learning of constant configurations elicited increased functional coupling of the precuneus with dorsal and ventral visual stream structures. Our results identify the precuneus as a key brain structure in the acquisition of detailed visuospatial information by orchestrating a parieto–occipito–temporal network.
A Framework for Understanding Systems Principles and Methods
Authors: Rousseau David 
Published: November 2018

ABSTRACTSystems engineering is increasingly challenged by the rising complexity of projects undertaken, resulting in increases in costs, failure rates, and negative unintended consequences. This resulted in calls for more scientific principles to underpin the methods of systems engineering. In this paper, it is argued that our ability to improve systems engineering's methods depends on making the principles of systemology, of which systems engineering is a part, more diverse and more scientific. An architecture for systemology is introduced, which shows how the principles of systemology arise from interdependent processes spanning multiple disciplinary fields, and on this basis a typology is introduced, which can be used to classify systems principles and systems methods. This framework, consisting of an architecture and a typology, can be used to survey and classify the principles and methods currently in use in systemology, map vocabularies referring to them, identify key gaps, and expose opportunities for further development. It may thus serve as a tool for coordinating collaborative work towards advancing the scope and depth of systemology
INCOSE Working Group Addresses System and Software Interfaces
Authors: Sheard Sarah , Creel Rita , Cadigan John , Marvin Joseph , Chim Leung , Pafford Michael E. 
Published: November 2018

ABSTRACTIn the 21st century, when any sophisticated system has significant software content, it is increasingly critical to articulate and improve the interface between systems engineering and software engineering, that is the relationships between systems and software engineering technical and management processes, products, tools, and outcomes. Although systems engineers and software engineers perform similar activities and use similar processes, their primary responsibilities and concerns differ. Systems engineers focus on the global aspects of a system. Their responsibilities span the lifecycle and involve ensuring the various elements of a system—such as hardware, software, firmware, engineering environments, and operational environments—work together to deliver capability. Software engineers also have responsibilities that span the lifecycle, but their focus is on activities to ensure the software satisfies software‐relevant system requirements and constraints. Software engineers must maintain sufficient knowledge of the non‐software elements of the systems that will execute their software, as well as the systems their software must interface with. Similarly, systems engineers must maintain sufficient awareness of the software to enable early identification and resolution of software risks and issues driven by other system elements. Thus, to enable continued progress in creating and sustaining capability in complex, interconnected systems, systems and software engineers must commit to improving the interfaces between their disciplines, to aligning and integrating their terminology, processes, methods, and tools.Recognizing the need to improve the system engineering‐software engineering interface, INCOSE approved the charter of the System and Software Interface Working Group (SaSIWG) in 2017. At its initial meeting at the INCOSE International Symposium 2017 (IS 2017) in Adelaide, Australia, the SaSIWG derived working group objectives from lists of brainstormed systems and software issues. This paper documents the interface issues elicited, grouped into seven categories, along with system‐ software interface use cases identified by SaSIWG members. The interface issues and use cases expose questions for the SaSIWG to prioritize and respond to. The paper concludes with a summary of the SaSIWG's plan to respond to these questions and strengthen the interface between the systems engineering and software engineering disciplines.
Comparison of the inhibitory potential towards carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase of chalcone and chalcone epoxide
Authors: Stellenboom Nashia 
Published: November 2018

AbstractChalcones and chalcone epoxides are important synthetic intermediates in organic and medicinal chemistry. Chalcones possess a broad spectrum of biological activities; however, 1,3‐diphenyl‐2‐propenone or chalcone has not been given the attention it deserve as its substituted derivatives. In this study, the inhibition effects of chalcone and its epoxidated derivative chalcone epoxide against human carbonic anhydrase isozymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) were evaluated. The results obtained showed that both compounds exhibited potent inhibitory activity, with IC50 values less than 10 µM. IC
50 values in the submicromolar (hCA I and hCA II) to low micromolar range (AChE and BuChE) were observed for both compounds. The mechanism of inhibition and the inhibitory constants (
K
i values) for each compound were also determined. Furthermore, chalcone epoxide was docked within the active sites of hCA I, hCA II, AChE, and BuChE to explore its binding mode with the enzymes.
Overexpression of RYBP inhibits proliferation, invasion, and chemoresistance to cisplatin in anaplastic thyroid cancer cells via the EGFR pathway
Authors: Tong Ai‐Hua , Tan Juan , Zhang Jin‐Hua , Xu Fang‐Jiang , Li Fu‐Yuan , Cao Chun‐Yu 
Published: November 2018

AbstractRing1 and YY1 binding protein (RYBP), a new member of the polycomb group protein family, has been reported to play an important role in various biological processes. Recently, more and more studies have demonstrated an implication of RYBP in cancer development. However, the specific role of RYBP in anaplastic thyroid cancer (ATC) remains unknown. In this study, we investigated for the first time the expression pattern and biological functions of RYBP in ATC. We showed that RYBP was lowly expressed in ATC tissues and cell lines. We also found that overexpression of RYBP inhibited ATC cell proliferation, invasion, and cisplatin resistance. Furthermore, we observed that upregulation of RYBP decreased the phosphorylation of EGFR and ERK1/2 in ATC cells. Taken together, our data indicated that RYBP might be considered as a promising therapeutic target for the treatment of ATC.
Effect of microRNA‐141 on the development of diabetic nephropathy through regulating AKT/AMPK signaling pathway by targeting insulin receptor substrate 2
Authors: Li Yang , Huang Denggao , Zheng Linlin , Cao Hui , Fan Zhongcheng 
Published: November 2018

AbstractObjectiveThe aim of this study was to explore the effect of microRNA‐141 (miR‐141) on the development of diabetic nephropathy (DN) and its potential mechanism.MethodsReal‐time quantitative polymerase chain reaction (RT‐qPCR) was used to detect the expression level of miR‐141 in peripheral blood of DN patients. Cell apoptosis was measured by flow cytometry. The expression levels of tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6) were detected by enzyme‐linked immunosorbent assay. The expression level of insulin receptor substrate 2 (IRS2) was analyzed by RT‐qPCR and Western blot analysis. The targeting regulatory sites were predicted by Targetscan and luciferase assay was conducted to confirm the relationship between miR‐141 and IRS2. The expression levels of protein kinase B (AKT)/adenosine monophosphate protein kinase (AMPK)‐related proteins were investigated by Western blot analysis.ResultsMiR‐141 was upregulated in peripheral blood of DN patients (P < 0.05). Upregulation of miR‐141 significantly promoted apoptosis (
P < 0.05) and the expression of TNF‐α and IL‐6 (
P < 0.05). However, downregulation of miR‐141 inhibited cell apoptosis (
P < 0.05) and productions of TNF‐α and IL‐6 (
P < 0.05). Moreover, miR‐141 displayed a negatively regulatory effect on IRS2 abundance, and overexpression of IRS2 reversed the inhibitory effect of miR‐141 on development of DN cells (
P < 0.05). Besides, knockdown of miR‐141 significantly promoted the expressions of AKT/AMPK‐related proteins (
P < 0.05), which was attenuated by inhibition of IRS2 (
P < 0.05).ConclusionMiR‐141 promoted DN progression through regulating AKT/AMPK signaling pathway by targeting IRS2.
Exploring scale validity and measurement invariance of the Toronto Mindfulness Scale across levels of meditation experience and proficiency
Authors: Ireland Michael J. , Day Jamin J. , Clough Bonnie A. 
Published: November 2018

AbstractObjectivesThe Toronto Mindfulness Scale (TMS) is a widely used instrument of state mindfulness. Research suggests the interpretation and functioning of mindfulness scale items may differ as a function of meditation experience, and thus, establishing invariance across experience levels is essential.MethodsFive hundred and five meditation practitioners (32.7% male, 33.3% female, and 34.1% unspecified) with an average age of 42.37 years (SD = 12.70) completed the TMS online.ResultsResults support at least partial invariance across subgroups based on years of mindfulness meditation experience and self‐reported proficiency. Construct validity of the Decentering subscale was also supported; however, the Curiosity subscale did not meet validity expectations, as it required additional model modifications to yield good fit, and means were not sensitive to differences in group experience or proficiency.ConclusionsOur findings suggest further review of the TMS Curiosity items may be warranted to determine its suitability for use within mindfulness assessment.
Chronic myeloid leukemia with complex karyotypes: Prognosis and therapeutic approaches
Authors: Asnafi Ali Amin , Deris Zayeri Zeinab , Shahrabi Saeid , Zibara Kazem , Vosughi Tina 
Published: November 2018

AbstractObjective and BackgroundChronic myeloid leukemia (CML) is a neoplastic disease whose genetic and cytogenetic changes play important roles in prognosis and treatment strategies. Philadelphia (Ph) translocation t(9;22)(q34;q11) is a diagnostic and prognostic biomarker in CML.MethodsPubmed and Google Scholar databases were searched for English language articles from 1975 to 2017 containing the terms CML; Additional chromosomal abnormalities; Philadelphia translocation; Prognosis; and Treatment.DiscussionApproximately 10–12% of CML patients exhibit additional chromosomal aberrations (ACAs) in chronic phase and blast crisis. ACAs emergence may cause different features in CML patients according to Ph pattern. For instance, deletion of chromosome 9 derivation is associated to patient’s bad survival, whereas monosomy 7 develops myeloid dysplastic syndrome (MDS) or acute myeloid leukemia (AML) in CML patients with Ph‐negative pattern. And ACAs in Ph‐positive CML is considered as a failure in the management of CML with imatinib.ConclusionCML classification using different features such as Ph and ACAs can play a decisive role in the evaluation of treatment responses in patients, for example, CML patients with Ph negative and monosomy 7 develop MDS or CML patient –Y and extra copy of Ph have a good response to tyrosine kinase inhibitors, therefore, classifications according to Ph and ACAs play an important role in choosing better treatment protocols and therapeutic strategies. Karyotype analysis in CML patients with complex karyotype shows unrandom pattern so ACAs can be great clue in medical guidelines.
DANCR contributed to hepatocellular carcinoma malignancy via sponging miR‐216a‐5p and modulating KLF12
Authors: Wang Jianchu , Pu Jian , Zhang Ying , Yao Tianwei , Luo Zongjiang , Li Wenchuan , Xu Guidan , Liu Juan , Wei Wujun , Deng Yibin 
Published: November 2018

AbstractLong noncoding RNA (lncRNA) differentiation antagonizing nonprotein coding RNA (DANCR) has been identified as an oncogene in several cancers. However, the biological function and role of DANCR in hepatocellular carcinoma (HCC) remain unclear. Our current study aimed to investigate the detailed mechanism of DANCR in HCC. We found that DANCR was significantly upregulated in HCC cell lines in comparison to LO2 cells. Then, we observed that knockdown of DANCR could greatly inhibit Huh7 and HepG2 cell proliferation. In addition, HCC cell apoptosis was increased by silence of DANCR and meanwhile, cell cycle progression was blocked in G1 phase. Apart from these, downregulation of DANCR repressed HCC cell migration and invasion ability obviously. As predicted by the bioinformatics analysis, microRNA‐216a‐5p (miR‐216a‐5p) could serve as a direct target of DANCR. MiR‐216a‐5p has been reported to be involved in many cancers. Here, the correlation between miR‐216a‐5p and DANCR was confirmed using dual‐luciferase reporter assay and radioimmunoprecipitation assay. Subsequently, Kruppel‐like factor 12 (KLF12) exerts an important role in different tumor types. KLF12 can function as a downstream target of miR‐216a‐5p. Finally, the in vivo experiments were used and the data proved that DANCR also strongly suppressed HCC tumor growth in vivo via targeting miR‐216a‐5p and KLF12. In conclusion, our study indicated that DANCR might provide a new perspective for HCC treatment.
Geographical traceability of wheat and its products using multielement light stable isotopes coupled with chemometrics
Authors: Wadood Syed Abdul , Boli Guo , Yimin Wei 
Published: November 2018

AbstractThe present study was aimed to investigate the variation of stable isotopic ratios of carbon, nitrogen, hydrogen, and oxygen in wheat kernel along with different processed fractions from three geographical origins across 5 years using isotope ratio mass spectrometry (IRMS). Multiway ANOVA revealed significant differences among region, harvest year, processing, and their interactions for all isotopes. The region contributed the major variability in the δ13C ‰, δ2H ‰, δ15N ‰, and δ18O‰ values of wheat. Variation of δ13C ‰, δ15N ‰, and δ18O ‰ between wheat whole kernel and its products (break, reduction, noodles, and cooked noodles) were ˂0.7‰, and no significant difference was observed, suggesting the reliability of these isotope fingerprints in geographical traceability of wheat‐processed fractions and foods. A significant influence of wheat processing was observed for δ2H values. By applying linear discriminant analysis (LDA) to the whole dataset, the generated model correctly classified over 91% of the samples according to the geographical origin. The application of these parameters will assist in the development of an analytical control procedure that can be utilized to control the mislabeling regarding geographical origin of wheat kernel and its products.
Numerical simulation of all optical demultiplexer based on pillar photonic crystal ring resonators
Authors: Mohammadi Masoud , Seifouri Mahmood 
Published: November 2018

AbstractWe present the numerical simulation of an all‐optical demultiplexer using 2D photonic crystal ring resonators for optical communications systems. The structure consists of three ring resonators, one bus waveguide, and three drop waveguides. The photonic crystal of the demultiplexer has a square‐shaped structure made up of silicon rods with lattice constant a = 548 nm, filling factor(r/a) of 0.18, where r is the radius of the rods, and linear refractive index of n = 3.4. The structure can filter three standard wavelengths with 4.2 nm channel spacing between the wavelengths. From the simulations, the mean quality factor and transmission efficiency of our structure are computed to be respectively 4936 and 96.5%, at wavelengths very close to 1.55 μm. The minimum and maximum values of crosstalk are −18.6 dB and −34.6 dB, respectively. The footprint of the device is 293.7 μm2, which is suitable for photonic integrated circuits. The optical characteristics and the behavior of the proposed demultiplexer have been achieved by means of finite‐difference time‐domain (FDTD) method.
Protein matrices ensure safe and functional delivery of rosmarinic acid from marjoram (Origanum majorana) extracts
Authors: Arranz Elena , Villalva Marisol , Guri Anilda , Ortego‐Hernández Elena , Jaime Laura , Reglero Guillermo , Santoyo Susana , Corredig Milena 
Published: November 2018

AbstractBACKGROUNDTo understand the interactions between carriers and functional ingredients is crucial when designing delivery systems, to maximize bioefficacy and functionality. In this study, two different protein matrices were evaluated as means to protect the extract isolated from marjoram leaves (Origanum majorana), casein micelles from fresh skim milk and soy protein isolate (SPI).RESULTSMarjoram extract was obtained from pressurization of ethanol and water solvent. Protein dispersions of casein and SPI (5 g L−1 each) with or without marjoram extract (0.1–3 mg mL−1) were prepared and homogenized. The physicochemical characterization of charge and entrapment efficiency were conducted. The results demonstrated that entrapment efficiency was highly dependent on the carrier itself where SPI formulations showed 20% higher affinity when compared to casein micelles. To investigate the physiological behaviour of the marjoram–protein dispersions, human macrophages were employed. A non‐specific inflammatory response of macrophages stimulated with bacterial lipopolysaccharide was measured for TNF‐α, IL‐1β and IL‐6 cytokine secretion.CONCLUSIONCasein and SPI protein formulations warranted high bioefficacy of marjoram extract, showing their potential as safe carriers. © 2018 Society of Chemical Industry