bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of Phthalate Exposure With Adiposity and Metabolic Syndrome in US Adolescents and Adults, NHANES 2013 to 2018
Authors: Webb Mary D , Park Jee Won , Day Drew B , Trabulsi Jillian C , Sathyanarayana Sheela , Melough Melissa M 
Published: October 2024

Abstract

Context
Phthalates are ubiquitous endocrine-disrupting chemicals and suspected obesogens. However, the associations with fat distribution and associated cardiometabolic complications remain unclear.

Objective
We examined the associations between phthalate exposure, body fat (total and distribution patterns), and metabolic syndrome (MetS) among US adolescents and adults.

Methods
We analyzed cross-sectional data from 829 adolescents and 3905 adults in the 2013 to 2018 National Health and Nutrition Examination Survey. Total percentage body fat (%BF), visceral adipose tissue (VAT) mass, and android to gynoid (A/G) ratio were determined using dual-energy x-ray absorptiometry. Associations between molar sums of low molecular weight (∑LMW), high molecular weight (∑HMW), and di(2-ethylhexyl) phthalate (∑DEHP) metabolites, and adiposity indicators and MetS were analyzed with multivariable linear and logistic regressions. Models included sex interaction terms, were stratified by age group, and adjusted for relevant covariates.

Results
∑HMW and ∑DEHP exposures were positively associated with %BF in males, and all phthalate groups were associated with greater VAT mass and A/G ratio in adolescent males. Five-fold increases in ∑HMW and ∑DEHP metabolites were associated with 21.7% (95% CI, 10.5-33.9) and 18.0% (95% CI, 7.72-29.2) greater VAT mass among adolescent males, respectively. Sex modified the relationship between ∑HMW exposure and A/G ratio among adolescents (interaction P value = .0185). Phthalates were not associated with odds of MetS. When assessing individual MetS components, phthalates were associated with hyperglycemia in adult males.

Conclusion
Greater exposure to phthalates was associated with greater %BF in all males, and with fat distribution in adolescent males; however, phthalates were not linked to MetS.
Y box-binding protein 1 regulates zebrafish folliculogenesis partly through p21-mediated control of follicle cell proliferation
Authors: Zhu Bo , Zhang Zhiwei , Pardeshi Lakhansing , Chen Yingying , Ge Wei 
Published: October 2024

ABSTRACT
Y box-binding protein 1 (Ybx1/ybx1) regulates gene expression through DNA/RNA binding. In zebrafish, Ybx1 is highly abundant in primary growth (PG) follicles in the ovary, but decreases precipitously as the follicles enter the secondary growth (SG). To understand Ybx1 function in folliculogenesis, we created a ybx1 mutant using TALEN and observed disrupted folliculogenesis during the previtellogenic (PV) to early vitellogenic (EV) transition of SG, resulting in underdeveloped ovaries and infertility. Expression and western blot analyses revealed differential gene expression between ybx1−/− and control ovaries, with significantly increased expression of cdkn1a (p21), a cell cycle inhibitor, in ybx1−/− follicles. While cdkn1a knockout via CRISPR/Cas9 was embryonically lethal, the heterozygote (cdkn1a+/−) displayed advanced follicle activation and maturation, contrasting with the ybx1−/− phenotype. Partial loss of p21 alleviated the ybx1−/− phenotype, restoring folliculogenesis with normal PG-PV and PV-EV transitions in ybx1−/−;cdkn1a+/− mutants. While ybx1−/− mutant follicle cells displayed poor proliferation in vivo and in vitro, the cells from the ybx1−/−;cdkn1a+/− follicles resumed normal proliferation. In conclusion, Ybx1 is crucial for early folliculogenesis in zebrafish, potentially by repressing cdkn1a expression, either directly or indirectly.
Counter-Activism Against Ideological Opponents: Evidence Based on the Competitive Dynamics of Corporate Engagement in Advocacy Giving
Authors: Seo Haram 
Published: October 2024

A growing body of literature has sought to understand the strategic drivers of corporate activism, emphasizing the ideological composition of a firm’s workforce as its salient internal driver. Despite these advancements, however, the heterogeneity in its effect remains underexplored, leaving it unclear when employee ideology is more likely to translate into activism. I address this gap by considering competitors’ actions—another important driver uncovered in the scholarship—as a key source of heterogeneity. I examine how these actions can shape the external context in which a firm’s employees evaluate the value of its activism, thereby influencing the firm’s incentives to act on employees’ preferences. My central conjecture is that activism by so-called ideological opponents of a firm’s employee base will be a particularly strong driver of its own activism. This is because actions taken by competitors who hold stances opposite to those valued by a firm’s employees can create a temporal window during which the firm can gain enough employee appreciation for its activism—particularly counter-activism opposing the stance of the competitor. Leveraging the donation records of corporate foundations to advocacy nonprofits as a novel channel for studying corporate activism, I find support for this conjecture. Consistent with my theory, I further find that this effect is driven by firms whose employees hold homogeneous ideological preferences and arises primarily around issues with strong ideological contention. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2023.17382 .
Correlates of Emotional and Tangible Reciprocity in Adult Siblings of Individuals With Autism
Authors: Burke Meghan M. , Li Chak , Arnold Catherine K. 
Published: October 2024

Abstract
Sibling relationships often involve exchanges of emotional and tangible support. When one sibling has a disability, the nature of the reciprocity of such support may differ from sibling pairs wherein no disability is present. Specifically, when an individual has autism, the nature of emotional and tangible reciprocity is unclear given the potential for a supportive or caregiving role of the sibling without autism. In this study, 256 adult siblings of autistic individuals completed a national survey. Analyses included descriptive statistics describing the nature of reciprocity and hierarchical regressions to identify the correlates of emotional and tangible reciprocity. Overall, participants often reported not giving or receiving much tangible support to/from their autistic sibling while they often gave and, to some extent received, emotional support from their autistic sibling. When the autistic sibling had more asocial behaviors, participants were more likely to provide emotional support than receive it. When participants engaged in more caregiving, they both gave and received more emotional and tangible support. Implications for research and practice are discussed.
Medication Management in Adults With Intellectual and Developmental Disabilities: Psychiatric Pharmacists in Primary Care
Authors: Moon Esther , Snyder Sabrina Domicoli , Williams Andrew , Allen Scott , Simmons Emma 
Published: October 2024

Abstract
This study describes the role of psychiatric pharmacists (PPs) in medication management at a county-hospital-based primary care clinic serving adults with intellectual and developmental disabilities (IDD). During a 20-week period, PPs provided 308 interventions for 97 patients with IDD, 55% of whom had a concomitant psychiatric/behavioral disorder and 70% of whom were taking at least one psychotropic medication. PP services included medication reviews (48%), medication histories (13%), collaborative care (12%), pharmacotherapy interventions (11%), advisory services (9%), and patient/caregiver education (7%). Psychotropics were involved in 66% of interventions. Our results demonstrate that PPs may address psychotropic-related challenges in this practice setting by performing a variety of services. Additional studies are needed to fully evaluate the impact of this integrative model.
Bone Mineral Density Screening in People With Epilepsy and Intellectual Disability
Authors: Gandelman-Marton Revital , Theitler Jacques 
Published: October 2024

Abstract
Vitamin D measurements and dual energy x-ray absorptiometry (DXA) scans are recommended in people with intellectual disability and/or epilepsy in order to prevent bone-linked harm. The prevalence of vitamin D supplementation and bone mineral density screening were evaluated in 68 people with epilepsy and intellectual disability (EID) and 68 matched controls with epilepsy without intellectual disability. DXA scans were not performed in any of the people with EID but were performed in 11.8% of the people in the control group. People with EID had a higher vitamin D supplementation rate and were treated with more antiepileptic drugs (AEDs) and more AED combinations, including first generation AEDs. Increased awareness of bone health screening in people with epilepsy and especially EID is warranted.
The Key Role of Gestures in Spatial Tasks for Students With Intellectual Disability
Authors: Lacombe Noémie , Dias Thierry , Petitpierre Geneviève 
Published: October 2024

Abstract
The gestures produced by children with intellectual disability (ID) in spatial tasks are rarely considered, although they have a supporting role in the formation of thought. In this research study, we analyzed the number of gestures, the type of gestures, and their role in the expression of knowledge of students with ID. Twenty students (12–17 years old) with ID and 40 students with typical development (TD) matched on visual-spatial level (n = 20) and on language level (n = 20) participated in the research. Students with ID made significantly more gestures in relation to the number of words spoken compared to their peers with TD. Thirty percent of the expressive communication of students with ID came from gestures alone, and 60% of the responses contained at least one gesture. Finally, the higher the level of task difficulty, the more gestures the students made.
Photonic gateway architecture extension and guard time-free initial connection method with point-to-multipoint remote control for metro/access converged all-photonics network
Authors: Kaneko Shin , Kimura Yasutaka , Igarashi Ryo , Shibata Naotaka , Suzuki Takahiro , Fujiwara Masamichi , Kani Jun-Ichi , Yoshida Tomoaki 
Published: October 2024

Emerging use cases with demanding bandwidth and latency requirements, as well as the challenge of reducing power consumption, are driving the need for evolution in optical network architectures. An all-photonics metro-access converged network (APN) aims to actualize a flat architecture by expanding dense wavelength-division-multiplexing (DWDM) metro networks into access areas. The APN flexibly and dynamically provides optical connectivity between any two points, even across the boundaries between access and metro areas according to individual application requirements and traffic-load status. To actualize and further evolve the APN concept, several technical challenges regarding access nodes, defined as Photonic Gateways (GWs), still remain. From an access node functionality perspective, first, the Photonic GW should forward various types of optical paths. Unlike reconfigurable optical add/drop multiplexers in current metro networks, which are specifically designed to cross-connect DWDM signals, the Photonic GW needs to handle various lights and optical signals, including short-reach applications and emerging non-communication use cases. Second, the Photonic GW should provide remote control channels to user terminals (UTs) in a more scalable and cost-effective manner within the node-footprint and power-consumption constraints. Remote and in-channel UT control is required to place flexibly the endpoints of a wavelength path, i.e., UT, beyond the control-plane network. Then, from the controller perspective, the physical connectivity between the newly connected UT and the access-side port of the Photonic GW should be autonomously identified for plug-and-play operation. Since UTs are widely distributed within an access area, there is a need for an initial connection method that does not require timing adjustments to connect to the APN between newly connected UTs. This paper presents an extension to the APN architecture that allows the Photonic GW to increase the types of accommodable optical paths and to enhance the scale of remote UT control. This paper also proposes an advanced initial connection method that works even when multiple UTs are simultaneously connected to the APN. The extension to the APN architecture and the initial connection method are verified through experiments based on a Photonic GW prototype that fully complies with the extended APN architecture and comprises four functionally disaggregated units, 100-Gb/s C-band DWDM digital coherent UTs, and 25-Gb/s O-band non-DWDM intensity modulation and direct detection UTs. A 10-gigabit-capable symmetric passive optical network is adopted for remote UT control. The proposed initial connection method eliminates the connection interval of 6 s or more between newly connected UTs and achieves guard time-free operation.
Chip-integrated extended-cavity mode-locked laser in the visible
Authors: Winkler Lisa V. , Neijts Govert , Bastiaens Hubertus M. J. , Goodwin Melissa J. , van Rees Albert , Schrinner Philip P. J. , Hoekman Marcel , Dekker Ronald , do Nascimento Jr. Adriano R. , van der Slot Peter J. M. , Nölleke Christian , Boller Klaus-J. 
Published: October 2024

Mode-locked lasers are of interest for applications such as biological imaging, nonlinear frequency conversion, and single-photon generation. In the infrared, chip-integrated mode-locked lasers have been demonstrated through integration of laser diodes with low-loss photonic circuits. However, additional challenges, such as a higher propagation loss and smaller alignment tolerances, have prevented the realization of such lasers in the visible range. Here, we demonstrate the first, to the best of our knowledge, chip-integrated mode-locked diode laser in the visible using an integrated photonic circuit for cavity extension. Based on a gallium arsenide gain chip and a low-loss silicon nitride feedback circuit, the laser is passively mode-locked using a saturable absorber (SA) implemented by focused ion beam (FIB) milling. At a center wavelength of 642 nm, the laser shows an average output power of 3.4 mW, with a spectral bandwidth of 1.5 nm at a repetition rate of 7.84 GHz.
Using a Bayesian analytic approach to identify county-level ecological factors associated with survival among individuals with early-onset colorectal cancer
Authors: Siddique Sunny , Baum Laura V. M. , Deziel Nicole C. , Kelly Jill R. , Warren Joshua L. , Ma Xiaomei 
Published: October 2024

Background
In the United States (US), incidence of early age of onset colorectal cancer (EOCRC, diagnosed <50 years of age) has been increasing. Using a Bayesian analytic approach, we evaluated the association between county-level ecological factors and survival among individuals with EOCRC and identified hotspot and coldspot counties with unexplained low and high survival, respectively.

Methods
Principal component (PC) analysis was used to reduce dimensionality of 36 county-level social, behavioral, and preventive factors from the Centers for Disease Control and Prevention data. Survival information was derived from the Surveillance, Epidemiology, and End Results Program data from January 1, 2000 to December 31, 2019. The association between the identified PCs and survival was evaluated using multivariable spatial generalized linear mixed models. Counties with residual low and high survival (i.e., unexplained by the PCs) were classified as hotspots and coldspots, respectively.

Results
Four PCs were used to explain the spatial variability in 5-year survival among 75,215 individuals with EOCRC: PC1) poverty, chronic disease, health risk behaviors (β = -0.03, 95% credible interval (CrI): -0.04, -0.03); PC2) younger age, chronic disease-free, minority status (β = -0.01, 95% CrI: -0.02, 0.00); PC3) urban environment, preventive services (β = 0.02, 95% CrI: 0.00, 0.03); and PC4) older age (-0.04, 95% CrI: -0.06, -0.02). Among individuals with distant malignancies, the residual spatial variability remained high for two US counties: 1) Salt Lake County, UT residents experiencing 26.5% (95% CrI: 1.5%, 47.8%) lower odds of survival [hotspot], and 2) Riverside County, CA residents experiencing 37% (95% CrI: 7.97%, 78.8%) higher odds survival [coldspot] after adjustment for county-level factors.

Conclusions
County-level ecological factors are strongly associated with survival among individuals with EOCRC. Yet there is some evidence of survival disparities among individuals with distant malignancies that remain unexplained by the included factors.
Comparison of intracompartment pressure changes in tibial plateau fractures and controlled people: A pilot study
Authors: Guo Jialiang , Zhang Jianfeng , Du Kezheng , Dong Weichong , Han Xiaohui , Zhang Yingze , Hou Zhiyong 
Published: October 2024

Objective
Acute compartment syndrome (ACS) is a serious medical condition that can be encountered in tibial plateau fractures. However, no studies of compartment pressure changes in patients with tibial plateau fractures compared to patient without fractures have been reported. To obtain a comprehensive understanding of the pressure changes in patients with fractures, we monitored and recorded the compartment pressure and attempted to reveal the potential pressure release function of the human fascia.

Materials and methods
Cohorts of 43 normal individuals and 23 patients (initial 33, 10 were excluded due to inclusion criteria) and include the number of patients who completed the study with closed tibial fractures (the fracture group, FG, which comprised 6 men and 17 women) were included in this retrospective research. Compartment pressures were measured with Icare, a device that is traditionally used to measure intraocular pressure. Results of measurements at 6 different locations in the lower limb were recorded and compared for three days (days 2, 3, and 4 post fracture) between normal cohort (CG) and fracture cohort (FG) patients.

Results
The compartment pressures were comparable at each pressure measurement site (upper, middle and lower) in patients of the CG and the FG. Compared with the CG patients, there was a significant increase in compartment pressure at the upper lateral location in 18-45-year-old patients in the FG (P = 0.013) and at the upper lateral (P = 0.004) and medial locations (P = 0.005) in 46-69-year-old patients, and the values tended to normalize over time. Compared with the contralateral normal limb of patients in the FG, there was a significant increase in compartment pressure at the upper lateral location in 18-45-year-old patients (P = 0.009) and at the upper lateral (P = 0.015) and medial locations (P = 0.016) in 46-69-year-old patients on the fractured side. Based on different fracture classifications, there were no significant differences in compartment pressure at the medial (upper, middle and lower) locations when compared with pressures at the corresponding lateral sites of measurement.

Conclusion
The results of this study revealed that the fascial compartment as a whole can release the increased intracompartment pressure after fracture to prevent complications such as acute compartment syndrome caused by a continued increase in pressure. The Icare as a portable device, is potentially useful in compartmental pressure measurement especially in emergency room.
Ulcerative Jejunitis in Celiac Disease: A 30-Year US Experience
Authors: Chornenkyy Yevgen , Peric Masa , Flores David Marin , Ono Yuho , Shinagare Shweta A. , Dannheim Katelyn , Shannahan Sarah , Rakowsky Shana , Asakrah Saja , Vyas Monika , Arnason Jon , Leffler Daniel , Kelly Ciaran , Mukherjee Rupa , Therrien Amelie 
Published: October 2024

INTRODUCTION:
Ulcerative jejunitis (UJ) or ulcerative enteritis (UE) is a rare complication of celiac disease (CeD). Guidelines regarding diagnosis and management are missing, and these cases have seldom been reported in the United States.

DESIGN:
Case series of CeD in which UE developed at a large academic center in the United States. Clinical presentation, diagnosis, treatment, and evolution of disease were collected.

RESULTS:
Eight cases were identified (6 male/2 female, mean age 59.5 [38–77] years). Presentations included intestinal obstruction (n = 3), GI hemorrhage (n = 3), and malabsorption (n = 2). Ulcers were present in the duodenum in 4 patients and exclusively past the angle of Treitz in only 4 cases, which makes the term UE more appropriate than UJ. Six of 8 had T-cell receptor clonal gene rearrangements, and 2 had definite aberrant T cells. Corticosteroids were tried in all patients without improvement, and 5 underwent surgical resection. Three patients received cladribine. One patient received an autologous stem cell transplant, followed by ruxolitinib. Two were subsequently diagnosed with enteropathy-associated T-cell lymphoma, including 1 with cerebral enteropathy-associated T-cell lymphoma, and 1 died from hemophagocytic syndrome. Two are still alive, including only 1 on GFD and 2 were lost to follow-up after surviving at least 30-month posttreatment.

DISCUSSION:
UE seems a more appropriate term to describe an ulcerative complication of CeD at high risk of obstruction or bleeding. Steroids were not effective. Treatment outcomes were variable, but with a 50% death rate.