bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substitution at Phenyl Rings of Chalcone and Schiff Base Moieties Accounts for their Antiproliferative Activity
Authors: Salem Marwa S. , Hussein Rasha A. , El-Sayed Wael M. 
Published: February 2019

Background:
In a continuous combat against cancer, which is one of the leading causes of mortality
now, chalcone and Schiff bases moieties have been incorporated and their antiproliferative activities and associated
mechanisms against liver (HepG2) and breast (MCF-7) cell lines in addition to normal fibroblasts (WI-38)
have been examined.

Methods:
Derivatives 4 and 5 of Schiff bases only and chalcone derivatives of Schiff bases 1 and 2 were devoid
of any antiproliferative activity. All three compounds (3, 6, and 7) with significant antiproliferative activity were
selective and caused no growth inhibition in normal fibroblasts. Derivative 3 was a chalcone only with IC50 of
~20 µM and has a very interesting signature where it enhanced apoptosis in HepG2 by stimulating the expression
of downstream execution caspase 3 without affecting neither p53 nor initiator caspase 9. In spite of the
structural similarity between compounds 6 and 7, compound 6 discerned itself with a unique IC50 of ~ 10 µM.

Results:
The antiproliferative activity of derivative 6 could be attributed to its unique capability of formation of
free radicals such as phenoxide radicals which arrested the cell cycle through enhancing the expression of p53
and induced apoptosis by induction of both caspases 9 and 3. It was the only investigated derivative that inhibited
the tyrosine kinase activity by 89%.

Conclusion:
The antiproliferative activity of the compounds under investigation considerably depended on the
nature of the substituent at position 4 in phenyl rings of both chalcone and Schiff base fragments. Derivative 6
with electron withdrawing chlorine substitution on the phenyl ring of Schiff base fragment and an electron donating
methoxy group on the phenyl ring of chalcone fragment was the most active member.
What is the Current Effectiveness of Olaparib for Breast Cancer Patients with a BRCA Mutation? A Systematic Review
Authors: Marsh Polly , Williamson Graham R 
Published: February 2019

Background:The Poly (ADP-ribose) polymerase inhibitor olaparib, acts against cancer cells in people with breast cancer pre-disposition gene mutations (BRCAm). Despite US and EU approval as a therapy for ovarian cancer patients with BRCAm, but research into olaparib therapy for breast cancer patients with BRCAm is in its infancy.Objective:As no systematic review has yet been undertaken to synthesise clinical trials looking at olaparib as a therapy for breast cancer patients with BRCAm, this systematic review aims to establish the current effectiveness of olaparib as a treatment for these patients.Methods:CINAHL, MEDLINE, Royal College of Nursing, Cochrane Library, Joanna Briggs Institute, Centre for Reviews and Dissemination, Internurse, Embase, Google Scholar and PubMed databases were searched, supplemented by a grey literature search, hand searching and cross-referencing. Authors independently reviewed and graded the studies also using Kmetet al. scoring system.Results:One long-term case study and six clinical trials were included. Heterogeneity prevented statistical meta-analysis, meaning only narrative synthesis was possible. The overall clinical benefit of olaparib appears to be greater and longer lived in BRCAm carriers compared to BRCAwt, and also when compared to standard chemotherapy treatments.Conclusion:Implications for nursing: nurses working in this field should be aware that the most compelling results were found in the subset of patients who harbour a BRCA mutation, meaning that olaparib should be regarded as a clinically effective potential therapy for these patients. Larger, longer-term trials including comparator arms are required to demonstrate benefits including overall survival, adverse effects and quality of life.
A Review of Different Types of DOE Methods as a Useful Platform for Improving the Performance of Nano Adsorbents in Removal Systems of Pollutants
Authors: Behmaneshfar Ali , Sadrnia Abdolhossein , Karimi-Maleh Hassan 
Published: February 2019

Background:
In recent years, the Design of Experiments (DOE) is used for removing
pollutant from wastewater by nano-adsorbent. Some methods are Taguchi, Response Surface
Methodology (RSM) and factorial design. The aim of this paper is to review different used
methods of DOE in removing pollutant to suggest some notations to scholars.

Methods:
The reviewed papers were searched in Google Scholar, Scopus, and Web of Science
randomly and categorized based on DOE methods.

Results:
Number of factors and responses in DOE for removing pollutants from wastewater are
between 2-6 and 1-4, respectively. There are several computer software programs that provide
simple use of these methods, such as Qualitek, Design Expert, Minitab, R and Matlab Programming.
All models have a coefficient of determination R-sq more than 0.9.

Conclusion:
All the mentioned methods are appropriate because of the high R-sq value. Since the
largest number of runs are used in RSM, it is not suitable for the experiments which are conducted
by expensive materials and process. Furthermore, Design Expert and Minitab are the most popular
software used by scholars in DOE methods for the removal of pollutant.
The Promising Signatures of Circulating microRNA-145 in Epithelial Ovarian Cancer Patients
Authors: Zuberi Mariyam , Mir Rashid , Khan Imran , Javid Jamsheed , Guru Sameer Ahmad , Bhat Musadiq , Sumi Mamta Pervin , Ahmad Imtiyaz , Masroor Mirza , Yadav Prasant , Vishnubhatla Sreenivas , Saxena Alpana 
Published: February 2019

Background:Epithelial ovarian cancer continues to be a deleterious threat to women as it is asymptomatic and is typically detected in advanced stages. Cogent non-invasive biomarkers are therefore needed which are effective in apprehending the disease in early stages. Recently, miRNA deregulation has shown a promising magnitude in ovarian cancer tumorigenesis. miRNA-145(miR- 145) is beginning to be understood for its possible role in cancer development and progression. In this study, we identified the clinicopathological hallmarks altered owing to the downexpression of serum miR-145 in EOC.Methods:70 serum samples from histopathologically confirmed EOC patients and 70 controls were collected. Total RNA from serum was isolated by Trizol method, polyadenylated and reverse transcribed into cDNA. Expression level of miR-145 was detected by miRNA qRT-PCR using RNU6B snRNA as reference.Results:The alliance of miR-145 profiling amongst patients and controls established itself to be conspicuous with a significant p-value (p<0.0001). A positive conglomeration (p=0.04) of miR-145 profiling was manifested with histopathological grade. Receiver Operating Characteristic (ROC) curve highlights the diagnostic potential and makes it imminent with a robust Area Under the curve (AUC). A positive correlation with the ROC curve was also noted for histological grade, FIGO stage, distant metastasis, lymph node status and survival.Conclusion:Our results propose that miR-145 down-regulation might be a possible touchstone for disease progression and be identified as a diagnostic marker and predict disease outcome in EOC patients.
Simulation and Experimental Investigation on Micro Electrochemical Milling of Micro Pattern Structures with High-Speed Helix Electrode
Authors: Kong Huanghai , Liu Yong , Wang Kan , Jiang Yong , Zhu Xiangming 
Published: February 2019

Background:
It is always difficult to fabricate micro parts in complicated machines. As one
of the most promising micro machining methods, micro electrochemical milling based on the principle
of anode electrochemical dissolution is useful for the fabrication of micro structures in hard metal material
with advantages irrespective of the material hardness and strength along with no residual stress or
heat treatment being observed on the surface of the workpiece.

Objective:
The purpose of this paper is to propose a method of micro pattern structures machining by
using high-speed helix electrode in micro electrochemical milling, and reveal the relationship of rotating
speed of helix electrode and machining efficiency.

Methods:
This paper presents a micro electrochemical milling technique for fabricating micro pattern
structures with high efficiency. Firstly, a mathematical model of gap electric field under the condition
of ultra short pulse power supply is established, and the surface profile change of workpiece in micro
electrochemical milling is simulated by COMSOL Multiphysics. Secondly, the gap flow field of the
machining under the conditions of different rotating speed of helix electrode is analyzed by simulation.
Finally, a set of experiments are carried out to discuss the influence of the rotating speed on maximum
feed rate.

Results:
The surface profile change of workpiece in micro electrochemical milling is predicted by
simulation. The graphs of gas-liquid distribution and velocity vector of the flow field in the machining
are obtained. A series of micro pattern structures with a groove width of 150μm are machined successfully.

Conclusion:
By using high-speed helix electrode, the electrolyte circulation can be promoted and machining
efficiency of micro electrochemical milling can be improved obviously. The experiment results
demonstrate that the micro electrochemical milling with high-speed helix electrode is an efficient
method to fabricate micro pattern structures. In this article, various patents have been discussed.
Puhumalla hallitseminen. Vahvan johtajuuden ilmentyminen Kekkosen radiopuheissa 1937–1967
Authors: Puro Jukka-Pekka 
Published: February 2019

Leadership through Speeches. The Manifestations of Strong Leadership in Kekkonen’s Radio Speeches of the Years 1937–1967Presidential radio speeches, as they were broadcast in Finland from the 1930s to the 1960s, were an integral part of Urho Kekkonen's political leadership and his position as the head of the state. In this article, Kekkonen’s speeches are divided into three genres: memorial speeches, New Year’s speeches, and foreign policy speeches. Each speech genre can be interpreted to avail various political ambitions and the political objectives strengthened during the time. In his first national radio speeches, Kekkonen was moderate and restraint, but during the 1950s the speeches became persuasive and eloquent. In Kekkonen’s most famous speeches of the 1960s, he applied diverse techniques of classic rhetoric aiming at strong rhetorical leadership. The 34 speeches, discussed in this article, are analyzed from the perspectives of neo-classical and generic rhetorical criticism.Puhumalla hallitseminen. Vahvan johtajuuden ilmentyminen Kekkosen radiopuheissa vuosina 1937–1967 Tarkastelen tässä artikkelissa Urho Kaleva Kekkosen vuosina 1937–1967 pitämiä radiopuheita. Radiopuheet olivat kiinteä osa Kekkosen poliittista johtajuutta ja hänen asemaansa valtionpäämiehenä. Puheet jaetaan artikkelissa kolmeen lajityyppiin: muistopuheisiin, uudenvuodenpuheisiin ja turvallisuuspuheisiin. Jokaisella lajityypillä voi tulkita olleen omat poliittiset tavoitteensa. Lajityyppien sisällä on paljon vaihtelua: Kekkosen radioretoriikkaa leimaa etenkin tarkastelujakson alkupuolella maltillisuus ja pidättyväisyys, mutta joissain 1960-luvun ulko- ja turvallisuuspoliittisissa puheissa voidaan havaita lähinnä uskonnolliselle retoriikalle ominaista hurmoshenkisyyttä. Kekkosta voidaan pitää monellakin tapaa klassisena poliittisena reettorina. Hän tunsi ja hallitsi monipuolisesti retoriikan tekniikoita eikä kavahtanut – kuten retorinen analyysi etenkin niin kutsuttujen yöpakkas- ja noottikriisipuheiden yhteydessä osoittaa – kovien tekniikoiden käyttämistä poliittisissa ristiriitatilanteissa.
THE IMPACT OF THE QUALITY OF INTRINSIC AND EXTRINSIC ATTRIBUTES IN CREATING LOYALTY AND PURCHASE INTENTION
Authors: . Albari , Dewi Sofian 
Published: February 2019

A business organization should always strive to maintain its sustainability by creating loyalty and purchase intention towards its products. The activity is specifically required for an organization engaged in the restaurant industry. The organization needs to be aware of which product attributes are in concern to the customers when purchasing the food in a restaurant. This research was intended to measure the importance of the quality from intrinsic and extrinsic attributes of a product for the customers and its impact on the customers’ loyalty and purchase intention. The research was conducted by involving the customers of a pizza product in Yogyakarta. 116 respondents were selected using convenience sampling technique. Meanwhile, the data being obtained were analyzed by using structural equation modeling (SEM) approach and data processing program named AMOS 20.0 after going through two stages of testing, namely data validity and data reliability tests. The results showed that the intrinsic attributes quality has a direct and positive impact on the customer’s purchase intention, but there is no impact on their loyalty. On the other hand, the extrinsic attributes quality has both direct and indirect impacts on the purchase intention through the loyalty mediator variable. The results also demonstrated the dominance of the importance of loyalty in the research model. This was indicated by the significance of direct impact or predictive total impact of loyalty towards purchase intention as compared to the impact of intrinsic and extrinsic attributes quality.
Acoso Laboral vs Síndrome de Cronos. Una carga emocional ética si no se sabe controlar
Authors: Nava Diamela 
Published: February 2019

El objetivo de la presente investigación tuvo como finalidad analizar el acoso laboral vs el síndrome de cronos como dos factores que afectan emocionalmente la salud mental del individuo. El estudio se basa en una metodología de tipo interpretativa, utilizando un diseño no experimental, mediante un análisis documental. Finalmente se logró considerar que el objetivo fundamental de ambos riesgos psicosociales es transformar moralmente al trabajador y destruirlo lentamente a través del abuso de poder, acoso moral, entre otros. No obstante, el jefe-cronos puede estar influenciado por el temperamento, carácter con sentimientos de inseguridad, miedo a ser desplazado, para poder sentirse identificado como una persona admirada en la organización para hacer valer su autoridad.
Valores organizacionales como soporte de la responsabilidad social en universidades privadas. Alianza de saberes y diálogo con el entorno
Authors: Paredes Abreu Yhoana , Seijo Suárez Cristina 
Published: February 2019

El presente estudio tiene como propósito analizar los valores organizacionales como soporte de la responsabilidad social en universidades privadas: alianza de saberes y diálogo con el entorno, sustentado en las teorías de valores organizacionales según Seijo y Avila (2009), García y Dolan (2003), Cortina (2005) Bllanchard y O’ Connor (2005), Whetten y Cameron (2011); y para la variable responsabilidad social en Guédez (2006), De la Cuesta (2004) Fernández (2005), Pelekais, Ferrer, Cruz y Romero (2007), Pelekais y Aguirre (2008). La investigación es de tipo documental, bajo el enfoque hermenéutico, a partir de la contrastación de teorías de los diversos autores que sustentan la investigación. Las reflexiones finales sugieren las universidades privadas como institución académica pero al mismo tiempo como una organización dentro de un entorno social, deben ir más allá de las prácticas sociales promovidas desde los departamentos de extensión.
A convivência com diabetes mellitus tipo 2
Authors: Beltrame Vilma , Brugnerotto Maura , Trentini Mercedes , Madureira Valéria S. F. 
Published: February 2019

Estudo qualitativo que teve como objetivo investigar a convivência dos sujeitos da pesquisa com a diabetes mellitus bem como o cuidado dispensado pela família ao diabético. Participaram deste estudo 20 pessoas com diabetes mellitus tipo 2, usuários do Programa de Atenção Básica, do Município de Concórdia – SC. Os dados foram obtidos por meio de entrevista, e organizados em quatro categorias: 1 – Reviravolta na vida, caracterizada por ter que seguir dieta, tomar os remédios, fazer atividade física e também como fator de isolamento social; 2 – Desgosto por não aceitar a doença; 3 – Cuidado familiar enumerado como apoio, dar os remédios, ajuda com a dieta, controle do resultado da glicemia, acompanhamento e participação nas consultas; 4 – Auto cuidado. Conclui-se que a diabetes mellitus requerem novas atitudes e a família é um importante fator que influencia na tomada de decisões frente ao novo estilo de vida que esta condição crônica impõe.
Educação ambiental X sustentabilidade: proposta de um plano de gerenciamento de resíduos de serviços de saúde
Authors: Povaluk Maristela 
Published: February 2019

Este estudo teve por objetivo verificar como a Secretaria Municipal de Saúde de Mafra faz a geração, segregação, acondicionamento, armazenagem, transporte, coleta e, o destino final dos resíduos gerados pelas Unidades de Saúde, para posteriormente elaborar uma proposta de Gerenciamento dos Resíduos de Serviço de Saúde, para priorizar a Educação Ambiental com ênfase na sustentabilidade. Caracterizou-se como pesquisa bibliográfica e de campo, por meio da aplicação de questionário e entrevistas. O estudo evidenciou que, 76% das unidades de saúde não possuem um local adequado para o acondicionamento dos resíduos desde a geração até a coleta para o destino final. Constatou-se ainda que todas as unidades produzem lixo reciclável, porém somente 53% fazem a separação destes resíduos, o restante das unidades destinam no mesmo recipiente dos resíduos comuns, elevando este índice para 90,4% de todos os resíduos gerados dentro da Secretaria Municipal. Após a interpretação dos dados consolidados, conclui-se que, as Unidades de Saúde não possuem a estrutura necessária para a segregação e armazenagem correta dos RSS, conforme determina a legislação, ainda faltam algumas adaptações na estrutura física. Para a elaboração do PGRSS a pesquisadora se embasou na RDC 306/2004 da ANVISA, juntamente a Resolução 283/2001 do CONAMA, que regulamentam o manejo dos resíduos. Desta forma, como objetivo final, a pesquisadora elaborou o PGRSS para ser apresentado a SMS contendo todas as etapas, partindo do orçamento dos custos para construção dos locais onde serão acondicionados os resíduos, até a coleta pela empresa contratada pela Secretaria.
Diversidade de borboletas (Lepidoptera) na borda e no interior de um fragmento de mata, no município de Seara – SC
Authors: Schmidt Deise Graciele , Costa Leila Cristina da , Campos Abner Elpino , Barp Elisete Ana 
Published: February 2019

O desenvolvimento de estudos em relação a biodiversidade vem ganhando destaque em publicações científicas. A Mata Atlântica é um ecossistema bastante complexo, possuindo uma alta biodiversidade ameaçada, sendo a principal causa a fragmentação. A ordem Lepidoptera é consideravelmente suscetível à fragmentação de habitats, por tal motivo é considerada um bioindicador. O presente trabalho teve como objetivo identificar a diversidade de espécies de Lepidoptera da borda e do interior de um fragmento de Mata Atlântica (Lato sensu), no município de Seara, SC. As coletas foram realizadas em seis trilhas, mensalmente, de Dezembro de 2010 a Novembro de 2011, com esforço amostral de 2 horas/rede/trilha, totalizando 144 horas de amostragem. Registrou-se um total de 274 indivíduos, pertencentes a de 5 famílias, 22 gêneros e 24 espécies. Em relação a diversidade (indíce de Shannon-Wiener H’) da borda e do interior, os dados da borda (H’) 2,19 e interior (H’) 2,30, não apresentaram diferença significativa entre os dois ambientes. Os valores encontrados para o índice de Shannon-Wiener foram comparados pelo teste “t” de Student, (t= -0,87), utilizando o programa Past. Assim, esses resultados indicam que a área encontra-se em um estado muito fragmentado, devido a extensão da borda e as trilhas do interior da mata formam pequenos fragmentos com grandes extensões de borda.
A ocorrência de estresse em policiais militares do 20º Batalhão de Polícia Militar de Concórdia - Santa Catarina
Authors: Spuldaro Josiane Carine , Nesi Tainara Cristina 
Published: February 2019

O presente estudo procurou avaliar a ocorrência de estresse entre os Policiais Militares do 20º Batalhão de Policia Militar de Concórdia – Santa Catarina. Para tanto, a pesquisa realizada foi de cunho quantitativo e envolveu vinte e quatro Policiais Militares do 20º Batalhão de Policia Militar de Concórdia – Santa Catarina. A coleta de dados foi realizada através de um teste Psicológico o Inventário de Sintomas de Stress para Adultos – ISSL. Os resultados refletem que 87% dos Policiais Militares apresentaram Estresse e 13% não apresentaram. Entre esses profissionais, 90% se encontram na fase de Resistência, seguida de 5% na fase de Quase-Exaustão, 5% na fase de Exaustão e 0% ou seja, não foi pontuada a fase de Alerta. Dos sujeitos que apresentaram estresse 50% sofrem com sintomas Psicológicos do estresse, 36% apresentam sintomas físicos e 14% sofrem de ambos os sintomas, físicos e psicológicos. Sobre os sintomas Psicológicos 26% dos Policias Militares sofrem com Irritabilidade excessiva; 23% Pensam/Falam constantemente em um só assunto; 19% apresentam Apatia, Depressão ou Raiva; 19% sofrem de Ansiedade e Angústia e 13% têm Perda do Senso de Humor. Em relação aos sintomas Físicos, 23% dos Policiais Militares sofrem com Tensão Muscular, 21% apresentam Cansaço Constante, 20% têm Problemas com a Memória, 19% apresentam Tiques e 17% sofrem com Insônia. Estes resultados refletem que a atividade militar se insere em um contexto de vulnerabilidade. Assim, tornam-se fundamentais propostas de intervenção que favoreçam as estratégias de enfrentamento.
Correlação entre rendimento e geração de resíduos sólidos na Região Metropolitana de São Paulo
Authors: Franca Fabiana Patrícia de Oliveira , Leis Fernanda Segantin , Boro Ivete , Importa Roseane Fernandes , Azevedo Sandra Aparecida da Silva , Carvalho Tatiana Dias , Abreu Luiz Carlos , Adami Fernando , Alvarenga Rogério , Habermann Mateus , Silva Odair Ramos , Fonseca Fernando Luiz Affonso 
Published: February 2019

INTRODUÇÃO: Considerando a discussão da gestão de resíduos sólidos urbanos (RSU) ao longo dos anos faz-se necessário um aprofundamento dos fatores que interferem no volume de lixo gerado pelos municípios, possibilitando um planejamento de seu descarte. OBJETIVO: avaliar a relação entre o volume de resíduos gerados e a renda dos moradores da região metropolitana de São Paulo. MÉTODOS: Foram obtidos dados de quantidade de RSU/habitante/dia e a renda per capita de 05 municípios do ABC Paulista, para o ano de 2009. A relação entre estas variáveis foi avaliada pelo teste de correlação de Pearson. RESULTADOS: Foi observada uma correlação positiva (r=0,67) e estatisticamente significante (p=0,003) entre o aumento do nível socioeconômico com a geração de massa RSU coletada. DISCUSSÃO: A correlação entre o volume de RSU e renda per capita reforça a necessidade de direcionar estudos sobre consumo e a geração de resíduos sólidos.