bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long intergenic non-coding RNA 1939 inhibits proliferation and migration of human renal cell carcinoma (RCC) cells by down-regulation of miR-154
Authors: Zhang Rongyuan , Huang Yuhua , Xu Baocai , Lv Chuan , Hou Jianquan , Zhang Weijie 
Published: June 2019

Abstract
Background: Renal carcinoma (RCC) is widely accepted as a malignant tumor of urinary system. Long intergenic non-coding RNA 1939 (LINC01939) is a novel lncRNA which was found to be down-regulated in RCC. Thus, we set out to explore the effect and regulation mechanism of LINC01939 in RCC.
Methods: LINC01939 and miR-154 in RCC tissues and cell lines were detected using qRT-PCR assay. Cell counting kit-8 (CCK-8) assays was exploited to examine cell viability. Flow cytometric analysis was conducted to examine apoptosis. Cell mobility was valued through wound healing assays. Western blotting was applied for examination of proteins related to proliferation, apoptosis, migration and Wnt/β-catenin/Notch.
Results: LINC01939 was down-regulated in RCC tissues. LINC01939 overexpression impeded proliferation and migration, and induced apoptosis. Further study found that the overexpression of LINC01939 strongly suppressed miR-154 expression. Then, the inhibiting effect of overexpressed LINC01939 on proliferation and mobility and the promoting role of LINC01939 in apoptosis were abolished by the combination of miR-154 mimic. Finally, we found that the overexpressed LINC01939 inactivated Wnt/β-catenin and Notch through suppressing miR-154.
Conclusion: The up-regulation of LINC01939 inhibited proliferation and migration of RCC cells by down-regulating miR-154.
Nomogram for predicting the survival of gastric adenocarcinoma patients who receive surgery and chemotherapy
Authors: Wang Chaoyang , Yang Jin , Zheng Zhongli , Li Binghui , Wang Yang , Ge Zheng , Jian Guangxu , Lyu Jun , Li Xiaodong , Ren Xue-Qun 
Published: June 2019

Abstract
Background: Surgery is the only way to cure gastric adenocarcinoma (GAC), and chemotherapy is the basic adjuvant management for GAC. A prognostic model for predicting the individual disease-specific survival (DSS) rates of GAC patients who receive surgery and chemotherapy has not been established.
Objective: We aimed to establish a survival nomogram for GAC patients who receive surgery and chemotherapy.
Methods: We identified 5764 GAC patients who had received surgery and chemotherapy from the SEER (Surveillance, Epidemiology, and End Results) database. Approximately 80% (n=4034) of the included patients were randomly assigned to the training set, and the remaining patients (n=1729) were assigned to the external validation set. Nomogram was established by the training set and validated by the validation set.
Results: Based on the results of a multivariate analysis, a nomogram was developed that encompassed age at diagnosis, number of regional lymph nodes examined, number of positive regional lymph nodes, sex, race, grade, derived AJCC stage, summary stage, and radiotherapy status. The C-index (Harrell’s concordance index) of the model was higher than that of the traditional seventh AJCC staging system (0.707 vs 0.661). Calibration plots of the nomogram showed that the probability of DSS optimally corresponded to the survival rate. Integrated discrimination improvement (IDI) and categorical net reclassification improvement (NRI) showed visible improvement. IDI for 3-, 5- and 10- year DSS were 0.058, 0.059 and 0.058, respectively (P>0.05), and NRI for 3-, 5- and 10- year DSS were 0.380 (95% CI=0.316–0.470), 0.407 (95% CI=0.350–0.505), and 0.413 (95% CI=0.336–0.519), respectively. Decision curve analysis supported that the constructed nomogram was superior to the AJCC staging system.
Conclusion: The proposed nomogram provides more-reliable DSS predictions for GAC patients who receive surgery and chemotherapy in the general population. According to validation, the new nomogram will be beneficial in facilitating individualized survival predictions and useful when performing clinical decision-making for GAC patients who receive surgery and chemotherapy.
The role of Double Strand Break Repair, Translesion Synthesis and Interstrand Crosslinks in Colorectal Cancer progression – clinicopathological data and survival.
Authors: Laporte Gustavo Andreazza , Leguisamo Natalia Meirelles , Glória Helena de Castro e , Azambuja Daniel de Barcellos , Kalil Antonio Nocchi , Saffi Jenifer 
Published: June 2019

Abstract
Abstract
Aim: To evaluate the prognostic value of molecular modulation of double strand break (DSBR) - XRCC2 and XRCC5 - core components; DNA damage tolerance/translesion synthesis (DDT/TLS) - POLH, POLK and POLQ – and, finally, of interstrand crosslink repair (ICLR) -DCLRE1A – pathways in sporadic colorectal cancer (CRC) progression.
Method: Tumour specimens and matched health mucosal tissues from 47 patients with CRC who underwent surgery were assessed for gene expression of XRCC2, XRCC5, POLH, POLK, POLQ and DCLRE1A by qRT-PCR; protein expression of Polk, Ku80, p53, Ki67 and mismatch repair MLH1 and MSH2 components were assessed by immunohistochemistry (IHC); CpG island promoter methylation of XRCC5, POLH, POLK, POLQ and DCLRE1A was performed. Uni and multivariate analyses were employed to determine associations with clinicopathological features and prognostic value of molecular data.
Results: Neoplastic tissues exhibited induction of POLK (p<0.001) and DCLRE1A (p<0.001) expression and low expression of POLH (p<0.001) and POLQ (p<0.001) in comparison to healthy paired mucosa. Low expression of POLH was associated to mucinous histology and T1-T2 tumors (p=0.038); low tumour expression of POLK was associated to distant metastases (p=0.042). POLK promoter methylation was associated to early stages CRC (p=0.011) and POLH promoter methylation to high grade tumors (p=0.023). CRC harbouring POLK promoter methylation exhibited better disease free survival (DFS) (p=0.005).
Conclusion: This study mainly demonstrated that low expression or unmethylated POLH and POLK were related to worse biological behavior tumors. However, POLK methylated was associated with better DFS. POLK and POLH are potential prognostic biomarkers in CRC.
Developing and Implementing a Faculty Development Curriculum in a Japanese Family Medicine Residency
Authors: Ie Kenya , Narushima Masato , Goto Michiko , Merenstein Joel , Wilson Stephen , Takemura Yousuke 
Published: June 2019

Abstract
Background and Objective

Despite the increase in family medicine residency in Japan, there are only a few structured faculty development (FD) programs. The objective of this project was to develop, implement, and evaluate a FD curriculum in Japan.

Methods

In 2015, a private FD initiative in the Mie University initiated a curriculum development in collaboration with FD fellowship at the University of Pittsburgh. A literature review and subsequent Delphi processes was conducted for competency development. Based on the competency list, we designed a two-year part-time FD curriculum. A course evaluation using pre-post confidence level and a focus group was held during March 2017.

Results

28 objectives were defined under five core domains: 1) care management/family medicine principle, 2) leadership/professional development, 3) administrative/management, 4) teaching, and 5) research/scholarly activity. The focus group identified five themes regarding the learning process: foundational soil; seedbed; sowing of seeds; nurture and growth; and reaping the harvest. A pre-post survey revealed significant increase in learner confidence for “care management/family medicine principle”(p=0.03), “teaching”(p<0.01), and “research/scholarly activity”(p<0.01), as well as the total score (p=0.03).

Conclusions

Further curriculum refinements will be required to see if the curriculum could be used for faculty development in other family medicine residencies.
Emergence Delirium in children is not related to intraoperative Burst Suppression – prospective, observational Electrography study
Authors: Koch Susanne , Stegherr Anna-Maria , Rupp Leopold , Kruppa Jochen , Prager Christine , Kramer Sylvia , Fahlenkamp Astrid , Spies Claudia 
Published: June 2019

Abstract
Background: Emergence-delirium is the most frequent brain dysfunction in children recovering from general anaesthesia, though the pathophysiological background remains unclear. The presented study analysed an association between emergence delirium and intraoperative burst suppression activity in the electroencephalogram, a period of very deep hypnosis during general anaesthesia.
Methods: In this prospective, observational cohort study at the Charité - university hospital in Berlin / Germany children aged 0.5 to 8 years, undergoing planned surgery, were included between September 2015 and February 2017. Intraoperative bi-frontal electroencephalogram were recorded. Occurrence and duration of burst suppression periods were visually analysed. Emergence delirium was assessed with the Pediatric Assessment of Emergence Delirium Score.
Results: From 97 children being analysed within this study, 40 children developed emergence delirium, and 57 children did not. Overall 52% of the children displayed intraoperative burst suppression periods; however, occurrence and duration of burst suppression (Emergence delirium group 55% / 261+462sec vs. Non-emergence delirium group 49% / 318+531sec) did not differ between both groups.
Conclusions: Our data reveal no correlation between the occurrence and duration of intraoperative burst suppression activity and the incidence of emergence delirium. Burst suppression occurrence is frequent; however, it does not seem to have an unfavourable impact on cerebral function at emergence from general anaesthesia in children.
Variation of bispectral index in children aged 1-12 years under propofol anesthesia: An observational study
Authors: Wang Fang , Zhang Jianmin , Yu Jie , Tian Muyang , Cui Xiaohuan , Wu Anshi 
Published: June 2019

Abstract
Background: The use of the bispectral index (BIS) is widespread in pediatric anesthesia, but few studies have attempted to perform a detailed evaluation of how BIS varies according to age in children under propofol anesthesia. This prospective study aimed to explore the exact relationship between BIS value and the age of 1- to 12-year-old children under propofol anesthesia. Methods: This study enrolled 165 children (1<yr≤12), scheduled for surgery under anesthesia, and divided them into 11 age groups. Of the 165 participants, 157 completed the study protocol. All patients were anesthetized with propofol for over 30 s. An observation period of 4 min followed. BIS values were recorded at 0 (immediately after propofol injection), 30, 40, 50, 60, 90, 120, 180, and 240 s after the injection. BIS values at each time point corresponding to the 11 age groups were compared using repeated measures ANOVA. Results: BIS values significantly differed among the nine time points (p<0.01) as well as among the different age groups (p<0.01) after propofol administration. Post-hoc Bonferroni tests showed a difference in BIS values between groups 1–4 (1<yr≤5) and groups 5–11(5<yr≤12). BIS values were lower in the latter than in the former, from 50 to 240 s. The minimum BIS values in group 1<yr≤5 and in group 5<yr≤12 were recorded at 60 s as 49 ± 17 and 35 ± 14, respectively.Conclusions: During propofol anesthesia, the BIS values were closely related to age, which can be divided into two groups: 1<yr≤5 and 5<yr≤12. BIS values of the older age group were lower than those of the younger age group at the same time points.
Signed Networks for the US Supreme Court Overturning its Prior Decisions
Authors: Doreian Patrick , Mrvar Andrej 
Published: June 2019

Abstract
This paper introduces the idea of studying the decision citation network of the US Supreme Court in a new fashion by focusing on this Court’s overturning of some of its prior decisions. Two departures from current practices were developed. One was to consider the phenomenon of overturning in a broader network context. The second was to treat the citations between overturning decisions and the overturned decisions as negative ties. This led to the creation of multiple signed citation networks. These networks were studied to get a better understanding of the operation of this Court. The results show that, frequently, when decisions are overturned, this is not done in a logically consistent fashion. A research agenda is proposed regarding a reexamination of stare decesis, thought to be a bedrock of the US legal system, and calling it into question as a genuine operating legal principle.
Infiltration from the Pedon to Global Grid Scales: An Overview and Outlook for Land Surface Modeling
Authors: Vereecken Harry , Weihermüller Lutz , Assouline Shmuel , Šimůnek Jirka , Verhoef Anne , Herbst Michael , Archer Nicole , Mohanty Binayak , Montzka Carsten , Vanderborght Jan , Balsamo Gianpaolo , Bechtold Michel , Boone Aaron , Chadburn Sarah , Cuntz Matthias , Decharme Bertrand , Ducharne Agnès , Ek Michael , Garrigues Sebastien , Goergen Klaus , Ingwersen Joachim , Kollet Stefan , Lawrence David M. , Li Qian , Or Dani , Swenson Sean , de Vrese Philipp , Walko Robert , Wu Yihua , Xue Yongkang 
Published: June 2019

Core Ideas
Land surface models (LSMs) show a large variety in describing and upscaling infiltration.
Soil structural effects on infiltration in LSMs are mostly neglected.
New soil databases may help to parameterize infiltration processes in LSMs.
Infiltration in soils is a key process that partitions precipitation at the land surface into surface runoff and water that enters the soil profile. We reviewed the basic principles of water infiltration in soils and we analyzed approaches commonly used in land surface models (LSMs) to quantify infiltration as well as its numerical implementation and sensitivity to model parameters. We reviewed methods to upscale infiltration from the point to the field, hillslope, and grid cell scales of LSMs. Despite the progress that has been made, upscaling of local‐scale infiltration processes to the grid scale used in LSMs is still far from being treated rigorously. We still lack a consistent theoretical framework to predict effective fluxes and parameters that control infiltration in LSMs. Our analysis shows that there is a large variety of approaches used to estimate soil hydraulic properties. Novel, highly resolved soil information at higher resolutions than the grid scale of LSMs may help in better quantifying subgrid variability of key infiltration parameters. Currently, only a few LSMs consider the impact of soil structure on soil hydraulic properties. Finally, we identified several processes not yet considered in LSMs that are known to strongly influence infiltration. Especially, the impact of soil structure on infiltration requires further research. To tackle these challenges and integrate current knowledge on soil processes affecting infiltration processes into LSMs, we advocate a stronger exchange and scientific interaction between the soil and the land surface modeling communities.
Results of the use of ramucirumab in combination with irinotecan and fluoropyrimidines in the second-line chemotherapy for disseminated gastric cancer
Authors: Besova N. S. , Titova T. A. , Stroyakovsky D. L. , Perminova E. V. , Bagrova S. G. , Obarevich E. S. , Gorbunova V. A. , Artamonova E. V. , Stilidi I. S. 
Published: June 2019

Background: Several studies show that the combination chemotherapy with ramucirumab allows to improve the treatment results of advanced gastric cancer (GC). Irinotecan with fluoropyrimidines is own of the second line chemotherapy options for these patients. As angiogenesis inhibitors can enhance the efficacy of chemotherapy, we investigated the combination of irinotecan and fluoropyrimidines with ramucirumab in metastatic GC.Methods: Eligible patients had advanced morphologically verified GC and disease progression during or within 4 months following first-line therapy. They received FOLFIRI plus ramucirumab (8 mg/kg on day 1) or XELIRI in combination with ramucirumab (8 mg/kg on days 1 and 8). The primary end point was progression-free survival (PFS). Secondary end-points were disease control rate (DCR) and safety.Results: Between September 2015 and April 2019, 39 patients (pts) were enrolled and 38 were evaluated for efficacy and toxicity. Median number of cycles was 9 (2-20). Seven patients achieved a partial response (PR) for an overall response rate of 17.9%. A total of 29 (74.4%) patients had stable disease (SD) for a DCR of 92.3%. With a median follow up 7,5 months, median PFS was 7.58 months (95% CI 6.6-8.5) and the median OS has not yet been reached. Median duration of PR response was 8,7 months (4,11-10,94+) and median duration of SD was 4,14 months (1,84-11,99+). The main treatment-related grade 3 or 4 adverse events were neutropenia (7/38; 18.4%), anemia (1/38; 2.6%) and diarrhea (2/38; 4.3%).The most frequent adverse events of special interest (AESIs) any grade were hypertension (16/38; 42.1%), bleeding/hemorrhage (10/38; 26.3%), proteinuria (6/38; 15.7%) and venous thromboembolic events (10/38; 26,3%). Gastrointestinal perforation developed in two patients (2/38; 5.3%). No treatment-related deaths occurred.Conclusion: In our research ramucirumab with irinotecan and fluoropyrimidines demonstrate the high activity and a manageable safety profile in patients with pre-treated metastatic GC
ASSESSMENT OF RELIABILITY OF ELECTRONICS COMPONENTS USING STATISTICAL PREDICTION METHODS
Authors: Arkhipova I. V. 
Published: June 2019

Ithin the framework of this article the question of gamma‑percentile time to failure of the electronic components of domestic production with strict performance requirements for resistance to external factors, as well as reliability, is considered. By now requirements in terms of gamma‑percentile time to failure of electronic components, used as part of advanced electronic equipment, reaching 150,000 hours under value of γ = 99%. Due to the increase in requirements for these products in terms  of reliability, there is a need to develop new ideas and methods of reliability theory. In this article it is proposed to estimate the gamma‑percentile time to failure on the basis of the results of measurements of parameters‑criteria of validity, controlled by accelerated tests for reliability.
SYSTEM OF AUTOMATIC SYNCHRONIZATION OF TEMPORAL POSITION OF EMITTED SIGNALS OF A SUBNANOSECOND PULSED PHASED ANTENNA ARRAY
Authors: Flerov A. N. , Flerova A. A. 
Published: June 2019

The structure of a pulsed phased antenna array (PPAA) of the sub nanosecond range with an automatic synchronization system  (ASS) of the temporal position of the emitted ultra‑wideband (UWB) pulses is presented. Considered aspects of the implementation of the components of the ASS. Particular attention is paid to the implementation of the temporary discriminator. The possibility of  implementing the ASS sub nanosecond time discriminator as a binary time comparator based on a high‑speed D‑trigger CMOS  series has been proved. It is shown that in the presence of jitter of the output pulse of the generator, the nonlinear model of the  system of automatic stabilization of the parameter with the characteristics of a relay type discriminator is reduced to a linear  model, which makes it possible to simply determine the main parameters and characteristics of the ASS. The results of the above  analysis were confirmed by laboratory and bench tests of the ASS elements and PPAA mock‑up samples.
SCIENTIFIC INSTRUMENT FOR COLLOIDAL SYSTEMS EXPERIMENTAL STUDYING IN MICROGRAVITY
Authors: Boreysho A. S. , Bakhanov I. S. , Kiselev I. A. , Rabchinskii M. K. , Chugreev A. V. 
Published: June 2019

Dispersia scientific instrument is designed to carry out series of experiments for the study of colloidal systems in microgravity conditions on the board of Russian Segment of the International Space Station. There are strong requirements on the reliability,  safety, mass and overall dimensions for spaceborn scientific instruments. The design and distinctive characteristics of the scientific instrument for study of processes of colloidal crystallization, aggregation, spinodal decomposition are discussed. The  experimental results of first ground tests are presented. The originally designed optic scheme for the analysis of static light scattering is described. Technical solutions developed to allow forming external stimuli to the studied sample are reviewed as  well. Finally, the experimental results on the study of colloidal system with the use of the developed scientific instrument during the first ground tests are presented.
Gait Abnormalities and the Risk of Falls in CKD
Authors: Tran Jeannie , Ayers Emmeline , Verghese Joe , Abramowitz Matthew K. 
Published: June 2019

Background and objectives
Older adults with CKD are at high risk of falls and disability. It is not known whether gait abnormalities contribute to this risk.

Design, setting, participants, & measurements
Quantitative and clinical gait assessments were performed in 330 nondisabled community-dwelling adults aged ≥65 years. CKD was defined as an eGFR <60 ml/min per 1.73 m2. Cox proportional hazards models were created to examine fall risk.

Results
A total of 41% (n=134) of participants had CKD. In addition to slower gait speed, participants with CKD had gait cycle abnormalities including shorter stride length and greater time in the stance and double-support phases. Among people with CKD, lower eGFR was independently associated with the severity of gait cycle abnormalities (per 10 ml/min per 1.73 m2 lower eGFR: 3.6 cm [95% confidence interval (95% CI), 1.4 to 5.8] shorter stride length; 0.7% [95% CI, 0.3 to 1.0] less time in swing phase; 1.1% [95% CI, 0.5 to 1.7] greater time in double-support phase); these abnormalities mediated the association of lower eGFR with slower gait speed. On clinical gait exam, consistent with the quantitative abnormalities, short steps and marked swaying or loss of balance were more common among participants with CKD, yet most had no identifiable gait phenotype. A gait phenotype defined by any of these abnormal signs was associated with higher risk of falls among participants with CKD: compared with people without CKD and without the gait phenotype, the adjusted hazard ratio was 1.72 (95% CI, 1.06 to 2.81) for those with CKD and the phenotype; in comparison, the adjusted hazard ratio was 0.71 (95% CI, 0.40 to 1.25) for people with CKD but without the phenotype (P value for interaction of CKD status and gait phenotype =0.01).

Conclusions
CKD in older adults is associated with quantitative gait abnormalities, which clinically manifest in a gait phenotype that is associated with fall risk.
RANCANG BANGUN APLIKASI SOSIAL MEDIA CRAWLER MENGGUNAKAN NODEJS MENERAPKAN KONSEP NON-BLOCKING I/O
Authors: Andika Chandra Yuda , Rudiarto Sabar 
Published: June 2019

Semakin majunya dunia teknologi dan informasi memberikan dampak besar bagi kehidupan kita, misal saja kemudahan akses komunikasi, berbicara pada orang lain cukup dengan benda kecil yang bisa kita masukan dalam saku celana, menyebarkan informasi ?, cukup dengan aplikasi – aplikasi yang tersedia, baik itu pada perangkat komputer maupun mobile, pada dasarnya informasi yang kita sebarkan memiliki nilai yang bisa dimanfaatkan melalui suatu analisa terlebih dahulu, namun saat ini pengambilan data data yang telah tersebar tersebut masih cukup sulit, karena saat ini aplikasi pengambilan data promrosesanya hanya dibuat pada satu layer yang mana promroseanya menerapkan antrian satu jalur, oleh karena itu diperlukan adanya aplikasi yang menerapkan konsep Non-blocking I/O pada pembangunan dan perancangan aplikasi bisa menjadi suatu solusi.