bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza‐like illness as a trigger for ischemic stroke
Authors: Boehme Amelia K. , Luna Jorge , Kulick Erin R. , Kamel Hooman , Elkind Mitchell S. V. 
Published: March 2018

AbstractObjectiveWe hypothesized that ILI is associated with risk of incident stroke, and that the risk would be highest closest in time to the event.MethodsThis case‐crossover analysis utilized data obtained from the California State Inpatient Database of the Healthcare Cost and Utilization Project (HCUP). The outcome of interest was ischemic stroke. Exposure was defined as a visit to the emergency department or hospitalization for influenza‐like illness (ILI) 365, 180, 90, 30, or 15 days before stroke (risk period) or similar time intervals exactly 1 or 2 years before stroke (control period). Conditional logistic regression was used to calculate the odds ratio and 95% confidence interval (OR, 95% CI).ResultsIn 2009, 36,975 hospitalized ischemic strokes met inclusion criteria, and of these strokes, 554 (1.5%) had at least 1 episode of ILI in the 365‐day risk period prior to their stroke. Using non‐overlapping time intervals from ILI to stroke, the odds of ischemic stroke was greatest in the first 15 days post ILI (OR: 2.88, 95% CI: 1.86–4.47). The strength of the relationship decreased as the time from ILI increased, and was no longer significant after 60 days. There was a significant interaction (P = 0.017) with age and ILI; the odds of stroke associated increased 7% with each 10‐year decrease in age (OR per 10‐year age decrease 1.07, 95% CI: 1.03–1.35).InterpretationWe found that ILI increases short‐term risk of stroke, particularly in people under the age of 45, and therefore may be considered to act as a trigger for stroke.
Self‐reported inner speech use in university students
Authors: Morin Alain , Duhnych Christina , Racy Famira 
Published: March 2018

SummaryRemarkably little is known regarding what people talk to themselves about (inner speech use) in their everyday lives. Existing self‐directed speech measures (e.g., thought sampling and questionnaires) either uniquely capture inner speech frequency and neglect its content or classify self‐reported thoughts instances in overly simplistic categories determined by the researchers. In the current study, we describe an open‐format thought listing procedure as well as a refined coding scheme and present detailed inner speech content self‐generated by 76 university students. The most frequently self‐reported inner speech activities were self‐regulation (e.g., planning and problem solving), self‐reflection (e.g., emotions, self‐motivation, appearance, behavior/performance, and autobiography), critical thinking (e.g., evaluating, judging, and criticizing), people in general, education, and current events. Inner speech occurred most commonly while studying and driving. These results are consistent with the self‐regulatory and self‐referential functions of inner speech often emphasized in the literature. Future research avenues using the open‐format inner speech listing procedure and coding scheme are proposed.
Model‐based vs data‐driven adaptive control: An overview
Authors: Benosman Mouhacine 
Published: March 2018

SummaryIn this paper, we present an overview of adaptive control by contrasting model‐based approaches with data‐driven approaches. Indeed, we propose to classify adaptive controllers into two main subfields, namely, model‐based adaptive control and data‐driven adaptive control. In each subfield, we cite monographs, survey papers, and recent research papers published in the last few years. We also include a few simple examples to illustrate some general concepts in each subfield.
Genetically Controlled Lysosomal Entrapment of Superparamagnetic Ferritin for Multimodal and Multiscale Imaging and Actuation with Low Tissue Attenuation
Authors: Massner Christoph , Sigmund Felix , Pettinger Susanne , Seeger Markus , Hartmann Carolin , Ivleva Natalia P. , Niessner Reinhard , Fuchs Helmut , de Angelis Martin Hrabě , Stelzl Anja , Koonakampully Neha Lal , Rolbieski Hannes , Wiedwald Ulf , Spasova Marina , Wurst Wolfgang , Ntziachristos Vasilis , Winklhofer Michael , Westmeyer Gil G. 
Published: March 2018

AbstractNanomaterials are of enormous value for biomedical applications because of their customizable features. However, the material properties of nanomaterials can be altered substantially by interactions with tissue thus making it important to assess them in the specific biological context to understand and tailor their effects. Here, a genetically controlled system is optimized for cellular uptake of superparamagnetic ferritin and subsequent trafficking to lysosomes. High local concentrations of photoabsorbing magnetoferritin give robust contrast in optoacoustic imaging and allow for selective photoablation of cells overexpressing ferritin receptors. Genetically controlled uptake of the biomagnetic nanoparticles also strongly enhances third‐harmonic generation due to the change of refractive index caused by the magnetite–protein interface of ferritins entrapped in lysosomes. Selective uptake of magnetoferritin furthermore enables sensitive detection of receptor‐expressing cells by magnetic resonance imaging, as well as efficient magnetic cell sorting and manipulation. Surprisingly, a substantial increase in the blocking temperature of lysosomally entrapped magnetoferritin is observed, which allows for specific ablation of genetically defined cell populations by local magnetic hyperthermia. The subcellular confinement of superparamagnetic ferritins thus enhances their physical properties to empower genetically controlled interrogation of cellular processes with deep tissue penetration.
The Relationship between Chemical Flexibility and Nanoscale Charge Collection in Hybrid Halide Perovskites
Authors: Luo Yanqi , Aharon Sigalit , Stuckelberger Michael , Magaña Ernesto , Lai Barry , Bertoni Mariana I. , Etgar Lioz , Fenning David P. 
Published: March 2018

AbstractHybrid organometal halide perovskites are known for their excellent optoelectronic functionality as well as their wide‐ranging chemical flexibility. The composition of hybrid perovskite devices has trended toward increasing complexity as fine‐tuned properties are pursued, including multielement mixing on the constituents A and B and halide sites. However, this tunability presents potential challenges for charge extraction in functional devices. Poor consistency and repeatability between devices may arise due to variations in composition and microstructure. Within a single device, spatial heterogeneity in composition and phase segregation may limit the device from achieving its performance potential. This review details how the nanoscale elemental distribution and charge collection in hybrid perovskite materials evolve as chemical complexity increases, highlighting recent results using nondestructive operando synchrotron‐based X‐ray nanoprobe techniques. The results reveal a strong link between local chemistry and charge collection that must be controlled to develop robust, high‐performance hybrid perovskite materials for optoelectronic devices.
Engineering of Mature Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Using Substrates with Multiscale Topography
Authors: Abadi Parisa P. S. S. , Garbern Jessica C. , Behzadi Shahed , Hill Michael J. , Tresback Jason S. , Heydari Tiam , Ejtehadi Mohammad Reza , Ahmed Nafis , Copley Elizabeth , Aghaverdi Haniyeh , Lee Richard T. , Farokhzad Omid C. , Mahmoudi Morteza 
Published: March 2018

AbstractProducing mature and functional cardiomyocytes (CMs) by in vitro differentiation of induced pluripotent stem cells (iPSCs) using only biochemical cues is challenging. To mimic the biophysical and biomechanical complexity of the native in vivo environment during the differentiation and maturation process, polydimethylsiloxane substrates with 3D topography at the micrometer and sub‐micrometer levels are developed and used as cell‐culture substrates. The results show that while cylindrical patterns on the substrates resembling mature CMs enhance the maturation of iPSC‐derived CMs, sub‐micrometer‐level topographical features derived by imprinting primary human CMs further accelerate both the differentiation and maturation processes. The resulting CMs exhibit a more‐mature phenotype than control groups—as confirmed by quantitative polymerase chain reaction, flow cytometry, and the magnitude of beating signals—and possess the shape and orientation of mature CMs in human myocardium—as revealed by fluorescence microscopy, Ca2+ flow direction, and mitochondrial distribution. The experiments, combined with a virtual cell model, show that the physico‐mechanical cues generated by these 3D‐patterned substrates improve the phenotype of the CMs via the reorganization of the cytoskeletal network and the regulation of chromatin conformation.
Progress and Perspective of Solid‐State Lithium–Sulfur Batteries
Authors: Lei Danni , Shi Kai , Ye Heng , Wan Zipei , Wang Yanyan , Shen Lu , Li Baohua , Yang Quan‐Hong , Kang Feiyu , He Yan‐Bing 
Published: March 2018

AbstractDue to high energy density, low cost, and nontoxicity, lithium–sulfur (Li–S) batteries are considered as the most promising candidate to satisfy the requirement from the accelerated development of electric vehicles. However, Li–S batteries are subjected to lithium polysulfides (LiPSs) shuttling due to their high dissolution in liquid electrolyte, resulting in low columbic efficiency and poor cycling performance. Moreover, the Li metal as an indispensable anode of Li–S batteries shows serious safety issues derived from the lithium dendrite formation. The replacement of liquid electrolytes with solid‐state electrolytes (SSEs) has been recognized as a fundamental approach to effectively address above problems. In this review, the progress on applying various classes of SSEs including gel, solid‐state polymer, ceramic, and composite electrolytes to solve the issues of Li–S batteries is summarized. The specific capacity of Li–S batteries is effectively improved due to the suppression of LiPSs shuttling by SSEs, while the rate and cycling performance remain relatively poor owing to the limited ionic conductivity and high interfacial resistance. Designing smart electrode/electrolyte integrated architectures, enabling the high ionic transportation pathway and compatible electrode/electrolyte interface, may be an effective way to achieve high performance solid‐state Li–S batteries.
In Situ Passivation for Efficient PbS Quantum Dot Solar Cells by Precursor Engineering
Authors: Wang Yongjie , Lu Kunyuan , Han Lu , Liu Zeke , Shi Guozheng , Fang Honghua , Chen Si , Wu Tian , Yang Fan , Gu Mengfan , Zhou Sijie , Ling Xufeng , Tang Xun , Zheng Jiawei , Loi Maria Antonietta , Ma Wanli 
Published: March 2018

AbstractCurrent efforts on lead sulfide quantum dot (PbS QD) solar cells are mostly paid to the device architecture engineering and postsynthetic surface modification, while very rare work regarding the optimization of PbS synthesis is reported. Here, PbS QDs are successfully synthesized using PbO and PbAc2 · 3H2O as the lead sources. QD solar cells based on PbAc‐PbS have demonstrated a high power conversion efficiency (PCE) of 10.82% (and independently certificated values of 10.62%), which is significantly higher than the PCE of 9.39% for PbO‐PbS QD based ones. For the first time, systematic investigations are carried out on the effect of lead precursor engineering on the device performance. It is revealed that acetate can act as an efficient capping ligands together with oleic acid, providing better surface coverage and replace some of the harmful hydroxyl (OH) ligands during the synthesis. Then the acetate on the surface can be exchanged by iodide and lead to desired passivation. This work demonstrates that the precursor engineering has great potential in performance improvement. It is also pointed out that the initial synthesis is an often neglected but critical stage and has abundant room for optimization to further improve the quality of the resultant QDs, leading to breakthrough efficiency.
A High‐Efficiency Organic Solar Cell Enabled by the Strong Intramolecular Electron Push–Pull Effect of the Nonfullerene Acceptor
Authors: Li Wanning , Ye Long , Li Sunsun , Yao Huifeng , Ade Harald , Hou Jianhui 
Published: March 2018

AbstractBesides broadening of the absorption spectrum, modulating molecular energy levels, and other well‐studied properties, a stronger intramolecular electron push–pull effect also affords other advantages in nonfullerene acceptors. A strong push–pull effect improves the dipole moment of the wings in IT‐4F over IT‐M and results in a lower miscibility than IT‐M when blended with PBDB‐TF. This feature leads to higher domain purity in the PBDB‐TF:IT‐4F blend and makes a contribution to the better photovoltaic performance. Moreover, the strong push–pull effect also decreases the vibrational relaxation, which makes IT‐4F more promising than IT‐M in reducing the energetic loss of organic solar cells. Above all, a power conversion efficiency of 13.7% is recorded in PBDB‐TF:IT‐4F‐based devices.
A High‐Capacity O2‐Type Li‐Rich Cathode Material with a Single‐Layer Li2MnO3 Superstructure
Authors: Zuo Yuxuan , Li Biao , Jiang Ning , Chu Wangsheng , Zhang Hao , Zou Ruqiang , Xia Dingguo 
Published: March 2018

AbstractA high capacity cathode is the key to the realization of high‐energy‐density lithium‐ion batteries. The anionic oxygen redox induced by activation of the Li2MnO3 domain has previously afforded an O3‐type layered Li‐rich material used as the cathode for lithium‐ion batteries with a notably high capacity of 250–300 mAh g−1. However, its practical application in lithium‐ion batteries has been limited due to electrodes made from this material suffering severe voltage fading and capacity decay during cycling. Here, it is shown that an O2‐type Li‐rich material with a single‐layer Li2MnO3 superstructure can deliver an extraordinary reversible capacity of 400 mAh g−1 (energy density: ≈1360 Wh kg−1). The activation of a single‐layer Li2MnO3 enables stable anionic oxygen redox reactions and leads to a highly reversible charge–discharge cycle. Understanding the high performance will further the development of high‐capacity cathode materials that utilize anionic oxygen redox processes.
Design and Fabrication of a Hierarchically Structured Scaffold for Tendon‐to‐Bone Repair
Authors: Zhu Chunlei , Pongkitwitoon Suphannee , Qiu Jichuan , Thomopoulos Stavros , Xia Younan 
Published: March 2018

AbstractA hierarchically structured scaffold is designed and fabricated for facilitating tendon‐to‐bone repair. The scaffold is composed of three regions with distinct functions: (i) an array of channels to guide the in‐growth of cells and aligned deposition of collagen fibers, as well as integration of the scaffold with the tendon side, (ii) a region with a gradient in mineral composition to facilitate stress transfer between tendon and bone, and (iii) a mineralized inverse opal region to promote the integration of the scaffold with the underlying bone. Cell culture experiments confirm that adipose‐derived stromal cells are able to infiltrate and proliferate through the entire thickness of the scaffold without compromised cell viability. The seeded stem cells exhibit directed differentiation into tenocytes and osteoblasts along the mineral gradient as a response to the gradient in Young's modulus. This novel scaffold holds great promise to promote the formation of a functional tendon‐to‐bone attachment by offering a structurally and compositionally appropriate microenvironment for healing.
3D Nanoporous Gold‐Supported Pt Nanoparticles as Highly Accelerating Catalytic Au‐Pt Micromotors
Authors: Jiang Jin‐Zhi , Ren Ling‐Qing , Huang Yu‐Ping , Li Xiao‐Dong , Wu Shao‐Hua , Sun Jian‐Jun 
Published: March 2018

AbstractA self‐supported, nanoporous gold microelectrode decorated with various nanoparticles can be used for real‐time electrochemical monitoring, and the high performance of these electrochemical biosensors originates from their unique and seamless solid/porous nanoarchitecture. In this work, new, 3D, nanoporous, gold‐supported Pt nanoparticles are fabricated by Au‐Zn alloying/dealloying and template membrane deposition methods to produce Au‐Pt micromotors with highly accelerated motion. The speed of the micromotors can reach 1025 µm s−1 in a 10% H2O2 solution, which is almost three times faster than unetched Au‐Pt micromotors. Four motion forms (circle, helical, circle and linear alternating, and linear) are demonstrated, and the speed of the circle motion is the fastest motion form. It is envisioned that the new fabrication method and enhanced motion can promote the micromotor efficiency for transport and delivery.
Widening the Temperature Range of Luminescent Thermometers through the Intra‐ and Interconfigurational Transitions of Pr3+
Authors: Brites Carlos D. S. , Fiaczyk Karolina , Ramalho João F. C. B. , Sójka Małgorzata , Carlos Luís D. , Zych Eugeniusz 
Published: March 2018

AbstractIn this study, it is shown how the temperature range of luminescent thermometers can be widened in an unprecedented way by combining the intra‐ and interconfigurational transitions of the Pr3+ ion in a single material. Using Sr2GeO4:Pr3+ crystalline powders as an illustrative example, the implementation of luminescence thermometry is reported in the broadest temperature range up to now (17–600 K) with a remarkable performance: maximum relative sensitivity values of 9.0% · K−1 (at 22 K, cryogenic range), 0.6% · K−1 (at 300 K, physiological range), and 0.5% · K−1 (at 600 K, high‐temperature range) and minimum temperature uncertainty of 0.1 K.
Wavenumber‐Splitting Metasurfaces Achieve Multichannel Diffusive Invisibility
Authors: Xu He‐Xiu , Zhang Lei , Kim Yongjune , Wang Guang‐Ming , Zhang Xiao‐Kuan , Sun Yunming , Ling Xiaohui , Liu Haiwen , Chen Zhining , Qiu Cheng‐Wei 
Published: March 2018

AbstractThe emerging invisibility schemes mainly adopt transformation optics, scattering cancellation, light diffusion, and metasurface‐based phase restoration techniques. However, those aforementioned invisibility achievements natively depend on the predefined curvature, polarization, frequency, and/or angle of the incident wave. Here, an invisibility strategy of using an ultrathin parabolic‐phase metasurface and its applications to achieve diffusive invisibility for dual‐polarization channels and multifrequency channels is reported. Such strategy can intrinsically split the wavenumber of the scattering wave and therein is termed as wavenumber‐splitting metasurface. For verification, two proof‐of‐concept examples are experimentally characterized. The first prototype manifests dual‐polarized near‐isotropic diffusive scattering immune from wide‐angle incidences. The second demonstration exhibits bifunctionality of combined diffusive invisibility and vortex scattering in dual‐polarization channels. In both cases, theoretical, numerical and experimental results agree well, illustrating a well‐separated triple‐band versatile scattering behavior. This approach addresses the fundamental issue of real invisibility under bistatic detection without complex optimization, thanks to the physical essence of numerous splitting wave vectors. Such strategy opens an upstream way to realize invisibility as well as holding the potentials for downstream applications such as stealth and camouflaging devices.
Silver‐Catalyzed Isocyanide Insertion into N−H Bond of Ammonia: [5+1] Annulation to Quinazoline Derivatives
Authors: Zhang Lingjuan , Li Juanjuan , Hu Zhongyan , Dong Jinhuan , Zhang Xian‐Ming , Xu Xianxiu 
Published: March 2018

AbstractA silver‐catalyzed [5+1] annulation of o‐acylaryl isocyanides with ammonium acetate and hydroxlamine was developed for the efficient and practical synthesis of quinazolines and quinazoline 3‐oxides in good to excellent yields, respectively. The domino process involved an unprecedented isocyanide insertion into the N−H bond of ammonia or hydroxylamine and followed by condensation reaction at ambient conditions.magnified image
Lewis‐acid Promoted Chemoselective Condensation of 2‐Aminobenzimidazoles or 3‐Aminoindazoles with 3‐Ethoxycyclobutanones to Construct Fused Nitrogen heterocycles
Authors: Kong Weiguang , Zhou Yao , Song Qiuling 
Published: March 2018

AbstractA Lewis‐acid promoted chemoselective condensation of 2‐aminobenzimidazoles or 3‐aminoindazoles with 3‐ethoxycyclobutanones is presented. Diverse fused heterocycles benzo[4,5]‐imidazo[1,2‐a]pyrimidine and pyrimido[1,2‐b]‐indazole derivatives were obtained in moderate to high yields under mild conditions, the reaction mechanism of which was in sharp contrast to previous [3+3] annulation reaction of 3‐ethoxycyclobutanones.magnified image
Recent Advances on Amino Acid Modifications via C–H Functionalization and Decarboxylative Functionalization Strategies
Authors: Mondal Santanu , Chowdhury Sushobhan 
Published: March 2018

AbstractOver the recent decade tremendous interest has been developed on the synthetic modification of natural as well as non‐proteinogenic amino acids and non‐natural linkages due to their immensely important applications in proteomics, diagnosis, and drug delivery etc. They are synthetically important also. For example, due to the high natural abundance of enantiopure amino acids, they and their derivatives are regularly employed in the development of several interesting synthetic methods, total syntheses of biologically related structures as well as in ligand elaboration. Thus, the synthetic field possesses a direct impact on several basic and applied sciences. But up to date only limited numbers of reviews are available which either appeared almost half a decade earlier or covered very specific areas of this highly expanding topic. Many achievements have already been realized in this field in the meantime which urgently need to be documented. Therefore, to meet the need this review is intended to cover the emerging versatile synthetic methods on the modification of amino acids and related structures over the recent decade with the relevant details of their respective prospects and problems in the best possible systematic and concise manner. Wherever needed relevant mechanistic details are also described.magnified image
Palladium‐Catalyzed Decarboxylative Cross‐Couplings of 1‐Boc‐3‐iodoazetidine: Regioselective Access to 2‐Alkynylazetidines, 3‐Alkynylazetidines and 3‐Vinylazetidines
Authors: Han Shuaijun , Ren Xiaoxiao , Wu Qingsong , Liang Apeng , Li Jingya , Zou Dapeng , Wu Yangjie , Wu Yusheng 
Published: March 2018

AbstractThe first palladium‐catalyzed decarboxylative coupling reactions of alkynyl carboxylic acids or α, β‐unsaturated carboxylic acids with 1‐Boc‐3‐iodoazetidine were described. The strategy could efficiently mediate β‐hydride elimination/migratory insertion sequence and selectively form 2‐alkynylazetidines (10 examples) and 3‐alkynylazetidines (15 examples) with high regioselectivity. The protocol provides convienient access to a variety of useful 3‐vinylazetidines in moderate yields (42%–72%) with good stereoselectivity. Notable advantages of this method include easy operation, mild reaction conditions, and wide substrate scope.magnified image
Divergent Synthesis of Quinoline Derivatives via [5+1] Annulation of 2‐Isocyanochalcones with Nitroalkanes
Authors: Bao Lan , Liu Jinglin , Xu Liang , Hu Zhongyan , Xu Xianxiu 
Published: March 2018

AbstractAn unprecedented substrate‐dependent [5+1] annulation of 2‐isocyanochalcones with nitroalkanes was developed for the efficient synthesis of functionalized quinolines and 3‐nitrodihydroquinolines. This transformation delivers both the aromatic and dihydroquinolines by selectively elimination or retention of the nitro group. Moreover, 3‐nitroquinolines and tricyclic pyrrolo[2,3‐c]quinolines were conveniently constructed from the resulting 3‐nitrodihydroquinolines through a single operation, respectively.magnified image