bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of long-range telesurgical robotic radical gastrectomy in a live porcine model
Authors: Chia Daryl Kai Ann , Suda Koichi , Ho Wei-En , Lee Bu Sung , Suzuki Kazumitsu , Shibasaki Susumu , Harada Tatsuhiko , Murai Jun , Oe Masafumi , Asai Hirochika , Tomine Takashi , Sato Hirotaka , Yoro Masahiro , Ohashi Masanao , Kitatsuji Hiroaki , Green Simon Peter , Xiong Ying , Shabbir Asim , Lomanto Davide , So Jimmy Bok Yan , Kim Guowei , Uyama Ichiro 
Published: November 2024

Background:
Telesurgery has been made increasingly possible with the advancements in robotic surgical platforms and network connectivity. However, long-distance transnational complex robotic surgeries such as gastrectomy have yet to be attempted.

Methods:
Multiple transnational network connections by Science Innovation Network (SINET), Japan Gigabit Network (JGN), and Arterial Research and Education Network in Asia-Pacific (ARENA-PAC) were established and tested by multiple surgeons in a dry box model. Surgeons’ perceptions of the different networks were recorded. Three robotic radical D2 gastrectomies in live porcine models were performed at a hospital in Toyoake, Japan, by a surgical team in a hospital in Singapore ~5000 km away, using the hinotori Surgical Robot System (Medicaroid Corporation).

Results:
The live porcine robotic gastrectomies were all completed in under 205 min with no intraoperative complications. From the different networks that were tested, the differences in latency ranged from 107 to 132 ms and did not translate to any significant differences in surgeon timings and perceptions.

Conclusions:
Transnational telesurgical radical D2 gastrectomy is feasible in a porcine model. There is no appreciable difference between surgeon performance and perception with network latencies of 107–132 ms. Long-range telesurgery as clinical practice may become possible in the future.
The triglyceride-glucose index as a new predictor of coronary artery complexity in elderly patients with non-ST-segment elevation acute coronary syndrome
Authors: Erbay Ilke , Gudul Naile Eris , Kokturk Ugur , Avci Ahmet 
Published: November 2024

Background
Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) has a significant impact on cardiovascular mortality in elderly patients. Identification of high-risk patients is essential to optimize clinical management. This study investigates the relationship between the TyG index and CAD complexity, as measured by the SYNTAX score, in elderly patients with NSTE-ACS.

Methods
We performed a retrospective analysis of 216 patients aged >65 years undergoing coronary angiography stratified according to tertiles of the TyG index and the SYNTAX score (SYNTAX score ≤ 22 versus SYNTAX score > 22).

Results
After adjustment for confounders, the TyG index was identified as an independent predictor of moderate/high scores (SYNTAX score > 22). As a continuous variable, it was significantly associated with moderate/high SYNTAX scores in both diabetic (P = 0.003) and nondiabetic groups (P = 0.004). When presented as a categorical variable, the TyG index remained a significant predictor after adjustment for sex, hypertension, BMI, and glomerular filtration rate. Compared with the T1 group, the risk of a moderate/high SYNTAX score was 5.410-fold (95% CI: 1.034–28.315; P = 0.046) and 7.774-fold (95% CI: 1.836–32.916; P = 0.005) higher in the T2 and T3 groups, respectively. The TyG index showed superior predictive ability for CAD complexity with an AUC of 0.747 compared with the AUC of 0.624 for HbA1c (P = 0.005).

Conclusion
This study showed that the TyG index is an independent predictor of moderate/high SYNTAX scores in elderly patients with NSTE-ACS, demonstrating superior predictive performance compared to HgA1c and highlighting its potential as a valuable tool for assessing CAD severity in this population.
Patient-Reported Outcome Measures in Routine Hematology Cancer Care
Authors: Kirkpatrick Suriya , Campbell Karen , Harding Samantha , Rudd Sarah 
Published: November 2024

Background
Hematological cancers have devastating effects on patients’ physical, emotional, and psychosocial health. There is growing evidence to support the use of patient-reported outcome measures (PROMs) through validated tools. Although PROMs are widely adopted in oncology, uptake in hematology remains limited in routine clinical care.

Objective
This review seeks to explore the utility of PROMs in routine hematology clinical practice and to understand the extent and type of evidence in relation to benefits of PROMs to patients.

Methods
The review was conducted in accordance with the Joanna Briggs Institute methodology for scoping reviews and the Preferred Reporting Items for Systematic reviews and Meta-Analysis scoping review model for organizing information.

Results
Ten thousand and seventy-one articles were identified, 110 full texts were reviewed, and 14 articles met the final inclusion criteria. More than 20 individual outcome measures were identified that fell into the following categories: accessibility and usability, self-efficacy, shared decision-making, and implementation.

Conclusions
Studies focused primarily on the choice of PROM, acceptability and usability, motivation for use, patient and healthcare professionals’ experience of using PROMs, the stated value of PROMs, and implementation advice. However, there are limited published studies supporting how PROMs can be adopted into routine care for people with hematological cancer.

Implications for Practice
There are various validated PROMs but limited research on how to meaningfully implement them to improve clinical and patient outcomes in the routine care of hematology patients.
Self-Regulated and Strategic Learning Practices as Predictors of Academic Performance in Novice Nursing Students
Authors: Eilts Jennifer S. 
Published: November 2024

Background:
Promoting the success and retention of novice nursing students requires a better understanding of how self-regulated and strategic learning approaches impact academic performance.

Purpose:
The purpose of this correlational study was to determine if there was a predictive relationship between the results of a self-regulated learning assessment and final grades in a foundational nursing course.

Methods:
The Learning and Study Strategies Inventory (LASSI) was used to collect data from a convenience sample of 75 students enrolled in an entry-level nursing course across 4 prelicensure programs. Scores were analyzed alongside demographic data and numeric grades at the end of the semester.

Results:
Results demonstrated the significant predictive abilities of LASSI scores related to Anxiety, Concentration, Information Processing, Motivation, and Test Strategies. Additionally, non-native English speakers experienced significantly lower course grades.

Conclusions:
Nurse educators can improve student performance in an introductory course by teaching and modeling self-regulated and strategic learning practices.
Predicting deep infection in pilon and tibial plateau fractures: a secondary analysis of the VANCO and OXYGEN trials
Authors: Overmann Archie L. , Carlini Anthony R. , O'Toole Robert V. , Castillo Renan C. , O'Hara Nathan N. ,   METRC
Published: November 2024

Abstract

Objectives:
To develop and validate a prediction model for a deep surgical site infection (SSI) after fixation of a tibial plateau or pilon fracture.

Design:
Pooled data from 2 randomized trials (VANCO and OXYGEN).

Setting:
Fifty-two US trauma centers.

Patients:
In total, 1847 adult patients with operatively treated tibial plateau or pilon fractures who met criteria for a high risk of infection.

Intervention:
We considered 13 baseline patient characteristics and developed and externally validated prediction models using 3 approaches (logistic regression, stepwise elimination, and machine learning).

Main Outcomes and Measures:
The primary prediction model outcome was a deep SSI requiring operative debridement within 182 days of definitive fixation. Our primary prognostic performance metric for evaluating the models was area under the receiver operating characteristic curve (AUC) with clinical utility set at 0.7.

Results:
Deep SSI occurred in 75 VANCO patients (8%) and in 56 OXYGEN patients (6%). The machine learning model for VANCO (AUC = 0.65) and stepwise elimination model for OXYGEN (AUC = 0.62) had the highest internal validation AUCs. However, none of the external validation AUCs exceeded 0.64 (range, 0.58 to 0.64).

Conclusions:
The predictive models did not reach the prespecified clinical utility threshold. Our models' inability to distinguish high-risk from low-risk patients is likely due to strict eligibility criteria and, therefore, homogeneous patient populations.
Iron Deficiency Anemia in Children During and After PICU Stay: Single-Center Retrospective Cohort, 2021–2022
Authors: Vadivelan Akhila , Nemeth Elizabeta , Ganz Tomas , Bulut Yonca 
Published: November 2024

OBJECTIVES:
The primary objective was to determine iron deficiency (ID) anemia (IDA) monitoring practices in children during PICU stay. A secondary objective was to determine the current follow-up practices for IDA after PICU discharge.

DESIGN:
Retrospective observational study of 2 years (2021–2022).

SETTING:
Single-center academic PICU in the United States.

SUBJECTS:
All patients younger than 18 years and excluded patients who died in the PICU or within 6 months of PICU discharge.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Anemia was defined by a hemoglobin concentration of less than 11 g/dL. ID was defined by either a ferritin of less than 30 ng/mL or a transferrin saturation (TSAT) of less than or equal to 20%. Suspicion for functional iron deficiency (SID) was defined by ferritin greater than or equal to 30 ng/mL and TSAT less than or equal to 20%, given the hyperferritinemic effect of inflammation. We documented serum iron, total iron binding capacity, TSAT, ferritin, and hemoglobin at PICU admission and discharge and 3 and 6 months after discharge. Overall, 913 of 1275 met the inclusion criteria, and 492 patients had a hemoglobin of less than 11 g/dL. Only 93 of 492 (18.9%) had iron studies at any time during the PICU stay. Among the 93 patients with iron studies, 20 patients (22%) were lost to follow-up. Of the remaining 73 patients, 67 of 73 had a hemoglobin checked at 3 months, of which 37 of 67 (55%) were still anemic. At 6 months, there were 64 of 73 patients who had a hemoglobin checked, of which 32 of 64 (50%) were still anemic. At 3 months, 39 of 73 (53%) had iron studies performed; of these, 13 of 39 had ID, 12 of 39 had SID, and 14 of 39 had neither ID nor SID. At 6 months, 35 of 73 (48%) had iron studies; of these, ten of 35 had ID, 11 of 35 had SID, and 14 of 35 had neither ID nor SID.

CONCLUSIONS:
Detection of ID and follow-up after PICU stay remain inadequate. We recommend that future studies assess the value of screening all critically ill patients for ID at the time of discharge and followed up, as necessary.
Current State of Stereotactic Body Radiation Therapy for Genitourinary Malignancies
Authors: Sherry Alexander D. , Desai Neil , Tang Chad 
Published: November 2024

Abstract
Stereotactic body radiation therapy (SBRT) involves the delivery of high-dose, highly precise radiation therapy to focal sites of gross tumor involvement. Recent advances in radiation planning and image guidance have facilitated rapid growth in the evidence for and use of SBRT, particularly for genitourinary malignancies, where the underlying radiobiology often suggests greater tumor sensitivity to SBRT than to conventionally fractionated radiation. Here, we review the evolution of SBRT for patients with prostate adenocarcinoma and renal cell carcinoma. We discuss state-of-the-art trials, indications, and future directions in the SBRT-based management of both localized and metastatic disease. With rapidly growing enthusiasm and evidence, clinical and translational research efforts on the biology and outcomes of SBRT over the coming decade will be crucial to refining the indications, technical approach, and synergistic combinations of SBRT with highly active systemic therapies and improve the efficacy and quality-of-life outcomes for patients with genitourinary malignancies.
Differences in multidimensional phenotype of 2 joint pain models link early weight-bearing deficit to late depressive-like behavior in male mice
Authors: Hestehave Sara , Florea Roxana , Fedorec Alexander J.H. , Jevic Maria , Mercy Lucile , Wright Annia , Morgan Oakley B. , Brown Laurence A. , Peirson Stuart N. , Géranton Sandrine M. 
Published: November 2024

Abstract

Introduction:
Chronic pain is a hallmark of joint diseases. Although these conditions are often accompanied by negative affective symptoms including depression and anxiety, these comorbidities are rarely studied simultaneously in preclinical models where they are poorly characterised. Moreover, how affective symptoms relate to the more obvious sensory and functional symptoms of joint diseases is not well understood. Here, we have addressed these gaps in knowledge.

Methods:
We used 2 preclinical models of joint pain in male mice and an array of behavioural and molecular assays to fully characterise functional deficits, mechanical hypersensitivity, affective symptoms, and nociceptive signaling in joint pain, as well as investigate their relationship.

Results:
Ankle joint inflammation and knee osteoarthritis induced mechanical hypersensitivity that lasted at least 3 months and that was not different between the 2 models on most days. However, the models presented with markedly different weight-bearing deficits, molecular profiles, and affective outcomes. Specifically, only the model of knee osteoarthritis was accompanied by an increase in negative affective behaviors, including early changes in circadian patterns, persistent cognitive impairments, and late development of depressive-like behavior. Importantly, the early weight-bearing deficit strongly correlated with the emotional profiles and the hypersensitivity at 3 months, suggesting that early objective functional measures may be used as predictors of long-term affective symptoms and pain.

Conclusion:
The predictive value of early weight-bearing deficit could prove useful in the clinical setting for adapted therapeutic approaches for the prevention of emotional comorbidities and better pain management for patients with joint pain.
Bone metabolism in complex regional pain syndrome
Authors: Harnik Michael A. , Sodmann Annemarie , Hartmannsberger Beate , Kindl Gudrun , Becker Juliane , Reinhold Ann-Kristin , Herrmann Eva , Buck Andreas K. , Dischinger Ulrich , Birklein Frank , Brack Alexander , Sawalma Abdelrahman , Rittner Heike L. 
Published: November 2024

Abstract

Introduction:
Patients with complex regional pain syndrome (CRPS) often show disturbed bone metabolism, assessed using three-phase bone scintigraphy (TPBS). However, current methods lack automation and standardisation. Bone serum markers have been proposed as biomarkers, but their utility is unclear.

Objectives:
This study aimed to evaluate bone metabolism in CRPS using TPBS and bone serum markers.

Methods:
A deep learning model for automated segmentation quantified tracer enhancement in TPBS images. Serum markers analysed included alkaline phosphatase (AP), 25-OH vitamin D, osteoprotegerin, procollagen type I N-terminal propeptide (PINP), and β-C-terminal telopeptide, compared to 48 healthy controls (HC). The study included 114 patients with CRPS, 41 of whom underwent TPBS.

Results:
Of the 41 patients with CRPS with TPBS, 39 (95.1%) displayed radiotracer enhancement in the bone phase across CRPS subtypes. Serum markers of 114 patients did not significantly differ between patients and HC, nor did they correlate with TPBS enhancement, except in warm CRPS. In these patients, TPBS accumulation in the metacarpophalangeal region correlated with PINP (Spearman ρ = 0.63, P = 0.038), and AP levels were elevated at 78 U/L (interquartile range 64–88) compared to cold CRPS at 66 U/L (51–77; P = 0.003) and HC at 60 U/L (53–69; P < 0.001).

Conclusion:
Automated TPBS quantification revealed widespread bone metabolism alterations, common in CRPS and detectable beyond qualitative assessment. Although most serum markers remained unchanged, patients with warm CRPS exhibited unique features, suggesting distinct pathophysiological profiles. Integrating novel image analysis with other biomarkers may enhance diagnostic precision and patient stratification for targeted therapies.
SARS-CoV-2 cross-sectional serosurvey across three HIV-1 therapeutic clinical trials in Africa
Authors: Papot Emmanuelle , Tovar-Sanchez Tamara , Woods Joana , Thaurignac Guillaume , Eriobu Nnakelu , Borok Margaret , Kaplan Richard , Avihingsanon Anchalee , Azwa Iskandar , Grinsztejng Beatriz , Kumarasamy Nagalingeswaran , Sokhela Simiso , Mpoudi-Etame Mireille , Arriaga Maria , Jacoby Simone , Matthews Gail V. , Losso Marcelo H. , Khoo Saye , Calmy Alexandra , Kouanfack Charles , Ayouba Ahidjo , Petoumenos Kathy , Venter W.D. Francois , Delaporte Eric , Polizzotto Mark N. ,   COHIVE study group∗
Published: November 2024

Objective:
Data on the impact of coronavirus disease 2019 (COVID-19) in people with HIV (PWH) are lacking in resource-constrained settings. We utilized existing randomized clinical trials (RCTs) on antiretroviral therapies (ART) in HIV-1 infection to conduct a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurvey, between January and March 2021, while characterizing participants’ features.

Design:
Cross-sectional serosurvey.

Methods:
Demographic characteristics, medical history and a serum sample were collected from consenting PWH. Samples were analyzed centrally for immunoglobulin G antibodies to recombinant nucleocapsid and spike proteins derived from SARS-CoV-2 using a Luminex based assay.

Results:
The 549 participants recruited in 9 sites across Africa had a median age of 40 years (interquartile range, IQR [34–45]); 63.0% (346) were female. All were on ART; 81.8% (449) had an HIV-1 viral load <50 copies/ml, with CD4+ cell count median at 478/mm3 (IQR [320–677]). None had received vaccination against SARS-CoV-2. Forty participants (7.3%) had a prior SARS-CoV-2 PCR testing, of whom 10 were positive (1.8%). Crude SARS-CoV-2 seroprevalence was 36.2% (95% confidence interval (CI) [32.2–40.4]). In the explorative multivariable analysis, comparison of the characteristics of PWH with a positive SARS-CoV-2 serology with those with a negative or indeterminate serology: PWH with a body mass index (BMI) ≥30 kg/m2 were more likely to have a positive serology than those with a BMI <25 (adjusted odds ratio (aOR) = 2.39 [1.48–3.86], P < 0.001); and PWH living in Cameroon were less likely to have a positive serology.

Conclusion:
This study demonstrates a substantial seroprevalence level of SARS-CoV-2 in PWH in the first quarter of 2021, with a marked disparity with the number of COVID-19 PCR tests reported positive.
Assessing Whether Providing Regular, Free HIV Self-Testing Kits Reduces the Time to HIV Diagnosis: An Internet-Based, Randomized Controlled Trial in Men Who Have Sex With Men
Authors: Dunn David T. , McCabe Leanne , Ward Denise , Phillips Andrew N. , Lampe Fiona C. , Burns Fiona , Delpech Valerie , Weatherburn Peter , Witzel T. Charles , Pebody Roger , Kirwan Peter , Khawam Jameel , Croxford Sara , Brady Michael , Fenton Kevin A. , Trevelion Roy , Collaco-Moraes Yolanda , McCormack Sheena , Rodger Alison J. 
Published: November 2024

Background:
The risk of onward HIV transmission is strongly influenced by the interval between HIV infection and its diagnosis. The SELPHI trial examined whether this interval could be reduced by offering free HIV self-testing kits to men who have sex with men (MSM).

Setting:
Internet-based RCT of MSM aged ≥16 years, resident in England/Wales, recruited through sexual and social networking sites.

Methods:
The second-stage randomization of SELPHI was open to participants who used an initial free HIV self-test kit, were HIV seronegative, and reported recent condomless anal sex. They were randomized to receive a free HIV self-test kit every 3 months (repeat testing [RT] group) versus no such offer (nRT group). The primary outcome was time from randomization to a confirmed HIV diagnosis, determined from linkage to national HIV surveillance databases. The key secondary outcome was the frequency of HIV testing regardless of test modality.

Results:
In total, 2308 eligible participants (1161 RT, 1147 nRT) were randomized between April 2017 and June 2018, and followed for 15–27 months. The proportion of participants reporting an HIV test in the previous 3 months was much higher in the RT group (86%) than in the nRT group (39%). Overall, 16 (9 RT, 7 nRT) confirmed HIV diagnoses were observed (0.35/100 person-years), with no difference between the groups (hazard ratio = 1.27 [95% CI: 0.47 to 3.41], P = 0.63).

Conclusions:
Providing regular free self-testing kits to sexually active MSM was highly acceptable and markedly increased HIV testing. However, in this low incidence cohort, it did not result in a demonstrably more rapid diagnosis of incident infections.
Clinical and Imaging Pulmonary Manifestations in IgG4-Related Disease
Authors: Gallo Jesica Romina , Froullet Cristian , Varizat Alejandro , Calvo Romina Andrea , Pisoni Cecilia , Cosatti Micaela , Bertoli Ana , Paira Sergio 
Published: November 2024

Objectives
The aims of this study were to describe the frequency of pleuropulmonary computed tomography (CT) findings in patients with IgG4-related disease (IgG4-RD) and to compare clinical and laboratory characteristics between patients with and without pleuropulmonary involvement in chest CT.

Methods
This is a study conducted within the IgG4-RD study group of the Argentine Society of Rheumatology (GESAR IgG4) cohort of patients with IgG4-RD. Member centers of the group were requested to submit pulmonary CT scans of the patients. Lung lesions were classified into 4 subtypes: (1) nodules, (2) ground-glass opacity, (3) interstitial-alveolar involvement, and (4) bronchovascular involvement. The presence of pleural involvement and mediastinal adenopathy was also assessed.

Results
We examined data from 28 patients, with 17 (61%) showing pulmonary involvement. The subtypes of pulmonary involvement, in order of frequency, were as follows: type 4 (n = 17, 100%), type 3 (n = 10, 59%), type 2 (n = 6, 36%), and type 1 (n = 5, 29%). Pleural lesions were observed in 2 (12%) cases, and mediastinal adenopathies were found in 4 (23%) cases. No demographic, clinical, or laboratory differences were noted between patients with and without pulmonary involvement, except for serum levels of IgG4, which were higher among patients without pulmonary involvement (339.0 [293.1–1592.1 mg/dL] vs 2869 [1156.3–4037.4 mg/dL]; p = 0.022).

Conclusions
In this case series, the predominant subtype of pulmonary involvement was septal thickening and increased bronchovascular tissue. Patients with and without pleuropulmonary involvement exhibited similar clinical and laboratory manifestations, except for serum IgG4, which was higher in patients without pleuropulmonary involvement.