bluuebunny/crossref_metadata_2025_split huggingface dataset:
Житие святых мучеников Ацискла и Виктории Кордувийских: ценность агиографической литературы в контексте миссионерского служения
Authors: Денис Юрьевич Куприченков 
Published: November 2024

Миссионерское служение как проповедь неповрежденного учения Церкви занимает одно из ключевых мест в деле сообщения социуму непреходящих истин и вечных ценностей, которые могли бы существенным образом способствовать решению ряда проблем мировоззренческого характера. В данном ключе житие свв. мчч. Ацискла и Виктории Кордувийских рассматривается в качестве важного звена в диалоге восточной и западной культур и компонента миссиологии, содержащего вероучительные принципы и нравственные имеративы. Специфика агиографической литературы заключается в репрезентации системы духовнонравственных ценностей в масштабе личных качеств конкретного святого, изображаемого через христоцентрическую модель осмысления действительности, исповедание Триединого Бога в качестве ценности совершенной и абсолютной, призвание человека к богоуподоблению. Рассматриваемое житие иллюстрирует важность решения свободно руководствоваться совокупностью базовых христианских ценностей и на их основе осуществлять течение жизни. Представленная статья будет полезна специалистам по истории Церкви, догматическому и нравственному богословию, филологии и культурологии.
Missionary service as the preaching of the intact teaching of the Church occupies one of the key places in the communication of eternal truths and eternal values to society, which could significantly contribute to solving a number of ideological problems. In this context, the lives of the holy martyrs Acisclus and Victoria of Cordova are considered as an important link in the dialogue of Eastern and Western cultures and a component of missiology containing doctrinal principles and moral imeratives. The specificity of hagiographic literature lies in the representation of the system of spiritual and moral values on the scale of the personal qualities of a particular saint, depicted through a christocentric model of understanding reality, the confession of the Triune God as a perfect and absolute value, the vocation of a person to godlike. The life in question illustrates the importance of the decision to be freely guided by the totality of basic Christian values and to carry out the course of life on their basis. The presented article will be useful to specialists in the history of the Church, dogmatic and moral theology, philology and cultural studies.
Lyme disease in Poland in 2022
Authors: Zbrzeżniak Jakub Maciej , Paradowska-Stankiewicz Iwona 
Published: November 2024

IntroductionIn Poland, Lyme disease has been subject to mandatory reporting and registration since 1996, and following EU law, cases of neuroborreliosis have been reported to the European Centre for Disease Prevention and Control (ECDC) since 2019. Lyme disease is transmitted by ticks of the Ixodes genus, and humans become infected through the bite of an infected tick. Due to the varied symptoms, diagnosis can be difficult and usually involves two-stage serological diagnostics. The aim of the study was to assess the epidemiological situation of Lyme disease in Poland in 2022 compared to the situation in previous years.Material and MethodsThe epidemiological situation of Lyme disease in Poland was assessed on the basis of the data sent to NIPH NIH – NRI by voivodeship sanitary-epidemiological stations and published in the bulletin “Infectious diseases and poisoning in Poland in 2022”.ResultsIn 2022, 17 369 cases of Lyme disease were registered, including 776 hospitalizations. This was a significant increase in cases by 38.96% and hospitalizations by 88.81% compared to the previous year. The seasonality that characterizes Lyme disease was noticeable in individual quarters, i.e. an increase in the number of cases from 1 151 in Q1 to 7 267 in Q3 and a decrease in Q4 to 5 708. At the voivodeship level, the highest incidence was recorded in the Podlaskie (81.2 per 100 000), Małopolskie (79.8 per 100 000) and Lubelskie (76.8 per 100 000) voivodeships.ConclusionsThe epidemiological situation of Lyme disease is gradually returning to the state before the COVID-19 pandemic. The percentage of hospitalized cases increased slightly (from 3.3% in 2021 to 4.5% in 2022), which, combined with the increase in the number of cases, meant an increase in the number of hospitalizations due to Lyme disease by almost 89%. The highest incidence was consistently observed in the eastern part of Poland (Podlaskie, Warmińsko-mazurskie, Lubelskie voivodeships).
Pengaruh Kebiasaan Belajar Terhadap Prestasi Belajar Akuntansi dengan Belejar Sebelum Ujian sebagai Variabel Moderator Siswa Jurusan Akuntansi SMK PGRI Pekanbaru Tahun Ajaran 2023/2024
Authors: Sukarni karni  , Wulandini Putri 
Published: November 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kebiasaan belajar terhadap hasil belajar. Cara belajar akan dilihat dari cara belajar dirumah, cara belajar di sekolah dan cara belajar bersama sama teman sarta cara belajar menghapi ujian pada mata pelejaran Akuntansi di SMK PGRI Pekanbaru. Jenis penelitian ini adalah penelitian kuantitatif eksplanasi. Penelitian ini ditujukan kepada siswa kelas X dan XI AK SMK PGRI Pekanbaru dengan jumlah 140 orang, sedangkan sampelnya dihitung menggunakan rumus Slovin sehingga diperoleh jumlah sampel 103 orang. Adapun teknik dalam pengambilan sampel yang digunakan dalam penelitian ini adalah proporsional random sampling. Sedangkan untuk pengambilan data dalam penelitian ini adalah menggunakan angket. Analisis hipotesis yang digunakan adalah regresi berganda dengan memefaatkan SPSS. Hasil penelitian diperoleh adalah Pengaruh langsung belajar di rumah terhadap hasil belajar sebesar 0,150 dan pengaruh tidak langsung belajar di rumah terhadap hasil belajar sebesar 0,075, maka memiliki arti bahwa pengaruh tidak langsung lebih kecil dibandingkan dengan pengaruh langsung. Dapat disimpulkan bahwa belajar di rumah secara tidak langsung terhadap hasil belajar tidak berpengaruh secara siknifikan. Pengaruh langsung belajar di rumah terhadap hasil belajar sebesar 0, 476 . Sedangkan pengaruh tidak langsung belajar di sekolah terhadap hasil belajar adalah 0,193arti bahwa pengaruh tidak langsung lebih kecil dibandingkan dengan pengaruh langsung. Dapat disimpulkan bahwa belajar di sekolah secara tidak langsung terhadap hasil belajar tidak berpengaruh secara siknifikan,
Toward a M2M-Based Internet of Vehicles Framework for Wireless Monitoring Applications
Authors: Ding Fei , Su Ruoyu , Tong En , Zhang Dengying , Zhu Hongbo , Mohamed Ismail Mohamed Wahab 
Published: November 2024

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<p>The Internet of Vehicles (IoV) has become an attractive research topic in the fields of communication networks and information processing due to its wide range of potential applications, including public transportation management, road traffic predication and control, environmental monitoring, and autonomous driving. Most research analyze the IoV’s data collected by dedicated machine-to-machine (M2M)-based platforms. Moreover, due to the lack of field experimental data, data transmission mechanisms from mobile vehicle terminals to the M2M-based platform rarely consider the proper transmission timing according to network performance and traffic conditions. To solve these problems, we propose an open M2M-based framework of wireless monitoring system for IoV. In the proposed framework, we design and implement a prototype of the mobile vehicle terminal. We also define the procedure of data transmission between the mobile vehicle terminal and the M2M-based platform. To prolong the lifetime of the mobile vehicle terminal, energy-efficient data transmission schemes for stopped and running vehicles are proposed, respectively, which reduce the unnecessary data transmission by jointly considering the variation of vehicle speed and received signal strength. We conduct a field experiment to verify the basic functions of the proposed M2M-based IoV monitoring system and the mobile vehicle terminal. Furthermore, the experimental results show that the proposed M2M-based platform with the mobile vehicle terminal enables customized and energy-efficient data delivery.</p>
The Investigation of Ideological Representations in Subtitling: A Critical Discourse Analysis Approach
Authors: Rahmani Kaouthar 
Published: November 2024

The present study investigates how ideologically-laden words and expressions are subtitled from English into Arabic by taking into account various translation strategies and lexical choices. It also sheds light on the role of the subtitler in this ideologically-constructed transfer. For this purpose, a mixed methods approach is followed to analyze and calculate the occurrence of the selected words and expressions from English movies and their Arabic subtitles by adopting the eclectic model of Farahzad’s critical discourse analysis model (2011), and Baker’s (2011) and Pedersen’s (2011) translation strategies. The results of the study show that the subtitlers try to convey different ideologies from the ones presented in the original dialogues by depicting Muslim characters as negative individuals and American characters as positive individuals who are saviors and defenders. This is revealed through omission, translation by more expressive words, addition, and generalization. The findings further highlight that the subtitlers attempted to match the subtitles to the religious beliefs of the target viewers through cultural substitution. Regarding shifts of agency or participants, the subtitlers employed addition by adding action verbs in the subtitles to change the meaning of the sequence or to alter the focus toward specific agents by using different pronouns. The study thereof shows the role of the subtitler as an unfaithful transmitter of reality in the subtitles.
Implementation Of Writing Skills Based On The Independent Curriculum In The seventh Grade Of MTsN 1 Kediri City
Authors: Naimah Ilfa , Sholihuddin Ahmad , Faiqoh Putri Kholida 
Published: November 2024

Learning writing skill in the seventh grade of MTsN 1 Kediri City is one of the language skills where students are expected to be able to develop Arabic writing skills well and master the basics of Arabic writing correctly. The research aims to find out the implementation of kitabah learning based on the independent curriculum and to find out the obstacles experienced by students during kitabah learning in the seventh grade of MTsN 1 Kediri City. The method used in this study is a qualitative research method that is descriptive. The research data was collected from primary data and secondary data sources with collection techniques using observation, interviews and documentation. The data analysis techniques used include data reduction, data presentation and conclusion drawing. The results of this research show that: (1) In the implementation of writing learning based on the independent curriculum, teachers have implemented differentiated learning by forming working groups with different student abilities. (2) Obstacles to the Implementation of Kitabah Learning, namely linguistic problems and nonlinguistic problems. As for the obstacles to the implementation of the independent curriculum, namely the lack of package books available in the library. So that not all students have books.
New series of 4,6-diaryl pyrimidines: facile synthesis and antiproliferative activity as dual EGFR/VEGFR-2 inhibitors
Authors: Mostafa Yaser A. , Assoud Jalil Abdeljalil , Desoky Ahmed Y. , Mohamady Samy , Mohamed Nesma M. , Salem Ola I. A. , Almarhoon Zainab M. , Bräse Stefan , Youssif Bahaa G. M. 
Published: November 2024

IntroductionWe developed and produced a new series of 4,6-diaryl-pyrimidines 9–29 as antiproliferative agents targeting EGFR/VEGFR-2.MethodsThe antiproliferative efficacy of the novel targets was assessed against a panel of 60 NCI cancer cell lines and four cancer cell lines in vitro.Results and DiscussionCompounds 14, 17, 19, 22, 25, and 29 demonstrated the greatest potency among the derivatives, with GI50 values between 22 and 33 nM; compounds 22 and 29 exhibited the highest potency, with GI50 values of 22 and 24 nM, respectively. We subsequently examined the most efficient derivatives as dual EGFR/VEGFR-2 inhibitors, finding that compounds 22 and 29 functioned as dual inhibitors. Moreover, 22 and 29 can act as apoptotic inducers by increasing Bax levels and decreasing levels of the anti-apoptotic protein Bcl2. At both 24- and 48-h intervals, the cell migration rates of compounds 22 and 29 were lower than those of untreated cells, according to the migration rate and wound closure percentage assessment. The wound closure rate reached 100% after 72 h of therapy with compound 22 but only 80% with compound 29. The docking study showed that compounds 22 and 29 had docking scores similar to those of Erlotinib and Sorafenib, co-crystallized ligands, for the EGFR and VEGFR-2 proteins. The experiments on lipophilicity showed that the new pyrimidines had a consistent result. This group of compounds has better biological activity in all the biological systems studied with low lipophilicity.
Association between hydroxychloroquine use and risk of diabetes mellitus in systemic lupus erythematosus and rheumatoid arthritis: a UK Biobank-based study
Authors: Li Chen-Xia , Fan Meng-Lin , Pang Bo-Wen , Zhou Xing-Jian , Zhang Hong-Zi , Zeng Jing-Jing , Yang Jin-Kui , Xu Shao-yong 
Published: November 2024

Context/ObjectivesHydroxychoroquine has hypoglycemic effects and may reduce the risk of diabetes mellitus (DM). We determined the association between hydroxychoroquine use and the incidence of DM in a population-based cohort of pations with Rheumatic diseaseMethodsA prospective cohort study among 502392 Potentially eligible participants in the context of UK Biobank, recruitment to the database began between 2006 and 2010. Patients diagnosed with diabetes and fasting glucose greater than or equal to 7 mmol/L at baseline (n=619) were excluded and patients diagnosed with either RA or SLE at baseline (n=6793) were followed up until 2022. Diagnosis was recorded using the International Classification of Diseases, tenth edition (ICD-10) code. The mean follow-up was 13.78 years and the primary outcome was newly recorded type 2 diabetes mellitus (T2DM), with the time of onset of diabetes as the follow-up endpoint date.ResultsDuring a median follow-up period of 13.78 (12.93, 14.49) years, diabetes developed in 537 participants, with an incidence of 7.9%. New diabetes cases not taking hydroxychloroquine and taking hydroxychloroquine was 504 (8.03%) and 33 (6.36%), respectively. In univariate models, the hazard ratio for diabetes was 0.89 (95% confidence interval, 0.81-0.98, P=0.014) for hydroxychloroquine users compared with those not taking hydroxychloroquine. After adjusting for age, sex, race, education level, and BMI the hazard ratio for incident diabetes among hydroxychloroquine users was 0.88 (95% confidence interval, 0.80-0.97, P=0.008). In complete multivariate model hazard ratio for hydroxychloroquine was 0.87 (95% confidence interval, 0.79- 0.96, P=0.005).ConclusionHydroxychloroquine was associated with decreased risk of DM among rheumatoid arthritis patients, our data taken together with correlational studies, warrant further investigation of the potential preventive effect of hydroxychloroquine against T2DM.
Evaluating the causal effects between Grave’s disease and diabetes mellitus: a bidirectional Mendelian randomization study
Authors: Zhang Yuhan , Fu Liuxiang 
Published: November 2024

BackgroundGraves’ disease (GD) is an autoimmune disease associated with an increased incidence of other autoimmune diseases. To investigate the causality between GD and Diabetes mellitus (DM), we designed bidirectional two-sample Mendelian randomization (MR) and multivariable MR (MVMR) studies.MethodsSingle-nucleotide polymorphisms (SNPs) associated with GD, thyroid peroxidase (TPO), thyroglobulin (Tg), thyroid-stimulating hormone (TSH), type 1 diabetes (T1D), and type 2 diabetes (T2D) were obtained from the IEU Open GWAS and FinnGen biobank databases. For the forward MR study, we used GD (sample size = 458,620) as the exposure and T1D (sample size = 520,580) and T2D (sample size = 211,766) as the outcomes. Next, high risk of T1D and T2D were used as exposure variables, and GD was used as the outcome variable for the reverse MR analysis. Finally, MVMR analysis was conducted to investigate the probable relationship between DM and indicators for thyroid function like TPO, Tg, and TSH. The inverse variance weighting (IVW) was used as the main method. Finally, the heterogeneity and sensitivity were assessed.ResultsThere were 27, 88, and 55 SNPs associated with GD, T1D, and T2D, respectively. A significant causal connection between higher genetic liability of GD and the risk of T2D (OR [95% CI] = 1.059 [1.025–1.095], P = 5.53e-04) was found in the forward MR analysis. Comparatively, the significant causal relationship between higher genetic liability of GD and the risk of T1D was not demonstrated (OR [95% CI] = 0.998[0.927,1.074], P=0.949). However, reverse MR suggested that there was a genetic susceptibility to T1D that increased the likelihood of developing GD (OR [95% CI] = 1.173[1.117,1.231], P = 1.913e-10), while T2D did not (OR [95% CI] = 0.963 [0.870–1.066], P = 0.468). Furthermore, there was inadequate evidence to suggest that abnormal TSH, TPO, and Tg levels increase the risk of incident T1D or T2D in individuals with GD. MVMR revealed no causal relationship among Tg, TSH, TPO, T1D, or T2D.ConclusionThere was no increased risk of T1D with an increase in genetic susceptibility to GD, although higher genetic susceptibility to T1D has been shown to be associated with increased risk of developing GD. A unidirectional causal relationship between the genetic liability for GD and increased risk of T2D was observed using MR analyses. MVMR analysis showed no statistically relevant causality between the genetic liability for TSH, TPO, or Tg and the risk of either T1D or T2D.
Case report: Infectious mononucleosis with bilateral retinal haemorrhages under myelin oligodendrocyte glycoprotein antibody-associated disease
Authors: Li Yuyu , Sun Mingming , Wei Shihui , Xu Quangang , Zhou Huanfen 
Published: November 2024

BackgroundBilateral optic neuritis associated with optic disc swelling is a common feature of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). However, extensive deep retinal haemorrhages have not been described in the context of MOG-associated optic neuritis. Here, we report a case of infectious mononucleosis with marked binocular peripapillary and perivascular haemorrhages as well as extensive deep retinal haemorrhages in the presence of MOGAD.Case reportA 39-year-old Chinese woman presenting with subacute binocular vision reduction with no light perception was diagnosed with MOGAD. Fundus examination revealed the presence of binocular peripapillary and perivascular haemorrhages as well as extensive deep retinal haemorrhages with severe optic disc swelling greater in the right eye than in the left and dilated and tortuous retinal venules. The patient tested positive for the Epstein–Barr virus (EBV) antigen (595 U/mL) and the EBV capsid antigen (&gt;750 U/mL). She had a fever and right upper quadrant abdominal pain, and a doctor determined splenomegaly 1 week before the onset of orbital pain and decreased vision acuity. Medical history and laboratory tests indicated the presence of concurrent infectious mononucleosis. Other investigational indicators of retinal haemorrhages, including hypertension, diabetes mellitus, vascular disease, systemic lupus erythematosus, metabolic disease, and renal or liver dysfunction, were absent.DiscussionThis case suggests that retinal haemorrhage is a possible complication of infectious mononucleosis in the presence of MOGAD.
Development and validation of a risk prediction model for postpartum urinary incontinence in primiparas with singleton pregnancies: a multicenter clinical investigation
Authors: Huang Xiaofeng , Qin Huangna , Kong Lin , Xia Hongwei , Lan Lixiang , Long Junqing 
Published: November 2024

BackgroundPostpartum urinary incontinence (UI) is a serious condition that significantly affects the quality of life. Several studies have demonstrated that it is associated with pelvic floor dysfunction. This study aimed to develop and validate a UI risk prediction model to identify primiparas with singleton pregnancies at high risk.MethodsA multistage stratified random sampling process was used. UI was measured using the International Standard Consultation on Incontinence Questionnaire Form (a modified Bristol questionnaire, ICIQ-FLUTS). Records of 1,340 primiparas with singleton pregnancies were reviewed, and data were collected from January 2014 to December 2014 in multiple centers. A univariate logistic regression analysis was performed, followed by a multivariable logistic regression analysis of the data. Using bootstrap resampling, we constructed a nomogram to assess postpartum UI risk.ResultsA total of 1,340 patients were enrolled, including 345 with postpartum UI and 995 with non-postpartum UI. The occurrence of postpartum UI was significantly related to the mode of delivery, family history of UI, coffee or tea consumption, antenatal UI, and frequent cough. The nomogram exhibited good discriminatory ability with a C-index of 0.718 (95% confidence interval: 0.684–0.752) and a bootstrap-corrected C-index of 0.716. Additionally, the calibration curve demonstrated that the predicted outcomes aligned well with the actual observations. Ultimately, the decision curve analysis indicated that the nomogram exhibited favorable clinical applicability.ConclusionThe decision curve analysis suggests that the nomogram could provide clinical value. The clinician will then feel more confident about making clinical recommendations regarding postpartum UI screening for primiparous women with singleton pregnancies.
Exploring the relationship between cathepsin and age-related macular degeneration using Mendelian randomization
Authors: Wang Qiuyuan , Cai Shanjun 
Published: November 2024

PurposeAge-related macular degeneration (AMD) is the leading cause of low vision and even blindness in the elderly population worldwide. However, no studies have been conducted to analyze the causal relationship between the cathepsin family and AMD. The present study aimed to explore and analyze this potential association using Mendelian randomization (MR).MethodsIn this study, AMD was classified into two types: exudative AMD and atrophic AMD. Inverse-variance weighting (IVW) was used as the main analysis method. The association between nine cathepsins and the two classifications of AMD were analyzed using multivariable Mendelian randomization (MVMR). Sensitivity analysis included Cochran’s Q-test and the MR-Egger intercept test.ResultsTwo-sample MR analysis showed that higher levels of cathepsin L2 were associated with a delay in the development of atrophic AMD (IVW: p = 0.017; OR = 0.885; 95% CI = 0.799–0.979). Reverse MR analysis indicated that cathepsin E levels were increased in individuals with atrophic (IVW: p = 0.023; OR = 1.058; 95% CI = 1.007–1.111) and exudative AMD (IVW: p = 0.018; OR = 1.061; 95% CI 1 = 1.010–1.115). MVMR analysis indicated a causal relationship between cathepsin G (IVW: p = 0.025; OR = 1.124; 95% CI = 1.014–1.245), cathepsin O (IVW: p = 0.043, OR = 1.158, 95% CI = 1.004–1.336), and exudative AMD after coordinating for other types of cathepsin.ConclusionThis study demonstrated a potential link between the cathepsin family and the onset of AMD. Elevated serum concentrations of cathepsin L2 may serve as a protective factor for atrophic AMD, while increased levels of serum cathepsin G and O concentrations may promote the development of exudative AMD. Besides, the development of AMD may be associated with elevated serum concentrations of cathepsin E.