bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topological Engineering of Photoluminescence Properties of Bismuth‐ or Erbium‐Doped Phosphosilicate Glass of Arbitrary P2O5 to SiO2 Ratio
Authors: Chu Yushi , Hu Qingliu , Zhang Yindong , Gao Zhigang , Fang Zaijin , Liu Lu , Yan Qiqi , Liu Yinyao , Sun Shiyu , Peng Gang‐Ding , Lewis Elfed , Ren Jing , Zhang Jianzhong 
Published: May 2018

AbstractA new method is reported to achieve the manufacture of glass of arbitrary ratio of SiO2/P2O5 which cannot be made by conventional melt‐quenching method. The new method is termed “melt‐in‐melt” which encapsulates the key step in the glass manufacturing process, i.e. one molten glass is poured into another molten glass with a stirring at high temperatures. Because of near unlimited possibilities in designing new glass compositions, there is a correspondingly great degree of freedom in the topological engineering of the glass structure, which in turn strongly influences the photoluminescence (PL) properties of active dopants. As a proof concept, bismuth and erbium are selected as the indicator dopants for emphasizing the real advantages of the new method as an effective means to tailoring the PL properties of the doped glasses. The micro structure and element distribution within the fabricated glasses are comprehensively characterized by high‐resolution scanning electron microscopy, micro‐Raman and high‐performance X‐ray fluorescence spectroscopy. Phase separation occurring at both nano‐ and meso‐scale is observed. Apart from the developed glasses being themselves promising broadband emission phosphors, the new glass‐making method may extend the possible applications of glass for important photonic applications (e.g. optical sensing, lighting, display, optical amplification and lasing etc.).
Absence of early HHV‐6 reactivation after cord blood allograft predicts powerful graft‐versus‐tumor effect
Authors: Rashidi Armin , Ebadi Maryam , Said Bassil , Cao Qing , Shanley Ryan , Curtsinger Julie , Bejanyan Nelli , Warlick Erica D. , Green Jaime S. , Brunstein Claudio G. , Miller Jeffrey S. , Weisdorf Daniel J. 
Published: May 2018

AbstractApproximately 75% of cord blood transplant (CBT) recipients experience human herpes virus‐6 (HHV‐6) reactivation. Considering the immunomodulatory effects of HHV‐6, we hypothesized that early HHV‐6 reactivation may influence the risk of relapse of the underlying hematologic malignancy. In 152 CBT recipients with hematological malignancies, we determined the association between HHV‐6 reactivation by day +28 and 2‐year cumulative incidence of relapse. In univariate analysis, the absence of HHV‐6 reactivation (n = 32) was associated with less relapse (26 [18‐35]% vs. 7 [0‐17]% in groups with vs. without HHV‐6 reactivation, respectively; P = .03). This difference was due to a remarkably low relapse incidence among patients without HHV‐6 reactivation. In multivariable analysis, the absence of HHV‐6 reactivation was associated with less relapse (hazard ratio [95% confidence interval]: 0.2 [0.05‐0.9], P = .03). This association was independent of patient‐, disease‐, and transplant‐related characteristics known to influence the risk of relapse. Natural killer cell and T‐cell reconstitution at day +28 were similar between patients with vs. without HHV‐6 reactivation. Our results suggest that CB allografts not complicated by HHV‐6 reactivation by day +28 have a powerful graft‐versus‐tumor effect. Knowledge about early HHV‐6 reactivation may stratify patients at day +28 into low vs. high relapse risk groups.
Dibenzofuran Synthesis: Decarbonylative Intramolecular C−H Arylation of Aromatic Esters
Authors: Okita Toshimasa , Komatsuda Masaaki , Saito Ami N. , Hisada Tomoya , Takahara Tomoaki T. , Nakayama Keito P. , Isshiki Ryota , Takise Ryosuke , Muto Kei , Yamaguchi Junichiro 
Published: May 2018

AbstractA method to provide dibenzofurans through decarbonylative C−H arylation is described. Diaryl ethers bearing an ester functional group, which can be readily prepared by a SNAr reaction, underwent intramolecular C−H arylation in the presence of a palladium catalyst to afford the corresponding dibenzofurans. Electron‐rich bis(dialkylphosphine)s such as dcype were critical as the ligand, otherwise the reactions did not proceed at all. This is the first example of C−H arylation of aromatic esters with simple arenes utilized in intramolecular fashion.
MaxSynBio: Wege zur Synthese einer Zelle aus nicht lebenden Komponenten
Authors: Schwille Petra , Spatz Joachim , Landfester Katharina , Bodenschatz Eberhard , Herminghaus Stephan , Sourjik Victor , Erb Tobias J. , Bastiaens Philippe , Lipowsky Reinhard , Hyman Anthony , Dabrock Peter , Baret Jean‐Christophe , Vidakovic‐Koch Tanja , Bieling Peter , Dimova Rumiana , Mutschler Hannes , Robinson Tom , Tang T.‐Y. Dora , Wegner Seraphine , Sundmacher Kai 
Published: May 2018

AbstractEin großes deutsches Max‐Planck‐Forschungskonsortium (“MaxSynBio”) untersucht lebende Systeme aus fundamentaler Perspektive. Das Forschungsprogramm von MaxSynBio verfolgt dabei ausschließlich einen “Bottom‐up”‐Ansatz in der synthetischen Biologie: Es konzentriert sich auf die detaillierte Analyse und das Verständnis essentieller Lebensprozesse, indem es diese Prozesse als elementare Module in minimalen synthetischen Systemen rekonstituiert. Das ultimative Ziel von MaxSynBio ist es, eine lebende Zelle komplett aus nicht lebenden Komponenten zu konstruieren. Die grundlegenden Erkenntnisse aus den Aktivitäten in MaxSynBio können auf lange Sicht zur Etablierung neuer biotechnologischer Verfahren führen, die auf synthetischen Zellkonstrukten basieren. Langfristig könnten dadurch Organismen ersetzt werden, die derzeit in der konventionellen Biotechnologie Verwendung finden.
Colossal Negative Thermal Expansion in Electron‐Doped PbVO3 Perovskites
Authors: Yamamoto Hajime , Imai Takashi , Sakai Yuki , Azuma Masaki 
Published: May 2018

AbstractColossal negative thermal expansion (NTE) with a volume contraction of about 8 %, the largest value reported so far for NTE materials, was observed in an electron‐doped giant tetragonal perovskite compound Pb1−xBixVO3 (x=0.2 and 0.3). A polar tetragonal (P4mm) to non‐polar cubic structural transition took place upon heating. The coefficient of thermal expansion (CTE) and the working temperature could be tuned by changing the Bi content, and La substitution decreased the transition temperature to room temperature. Pb0.76La0.04Bi0.20VO3 exhibited a unit cell volume contraction of 6.7 % from 200 K to 420 K. Interestingly, further gigantic NTE of about 8.5 % was observed in a dilametric measurement of a Pb0.76La0.04Bi0.20VO3 polycrystalline sample. The pronounced NTE in the sintered body should be attributed to an anisotropic lattice parameter change.
Enhancing Temporal Control and Enabling Chain‐End Modification in Photoregulated Cationic Polymerizations by Using Iridium‐Based Catalysts
Authors: Kottisch Veronika , Supej Michael J. , Fors Brett P. 
Published: May 2018

AbstractGaining temporal control over chain growth is a key challenge in the enhancement of controlled living polymerizations. Though research on photocontrolled polymerizations is still in its infancy, it has already proven useful in the development of previously inaccessible materials. Photocontrol has now been extended to cationic polymerizations using 2,4,6‐triarylpyrylium salts as photocatalysts. Despite the ability to stop polymerization for a short time, monomer conversion was observed over long dark periods. Improved catalyst systems based on Ir complexes give optimal temporal control over chain growth. The excellent stability of these complexes and the ability to tune the excited and ground state redox potentials to regulate the number of monomer additions per cation formed allows polymerization to be halted for more than 20 hours. The excellent stability of these iridium catalysts in the presence of more nucleophilic species enables chain‐end functionalization of these polymers.
Blurring the Lines between Host and Guest: A Chimeric Receptor Derived from Cucurbituril and Triptycene
Authors: Lu Xiaoyong , Samanta Soumen K. , Zavalij Peter Y. , Isaacs Lyle 
Published: May 2018

AbstractWe report the synthesis and X‐ray crystal structure of a cucurbituril–triptycene chimeric receptor (1). Host 1 binds to guests typical of CB[6]–CB[8], but also binds to larger guests such as blue box (20) and the Fujita square (22). Intriguingly, the geometries of the 1⋅20 and 1⋅22 complexes blur the lines between host and guest in that both components fulfill both roles within each complex. The fluorescence output of 1 is fully quenched by the formation of complexes with pyridinium‐derived guests.
[Hg4Te8(Te2)4]8−: A Heavy Metal Porphyrinoid Embedded in a Lamellar Structure
Authors: Donsbach Carsten , Reiter Kevin , Sundholm Dage , Weigend Florian , Dehnen Stefanie 
Published: May 2018

AbstractThe use of ionic liquids (CnC1Im)[BF4] with long alkyl chains (n=10, 12) in the ionothermal treatment of Na2[HgTe2] led to lamellar crystal structures with molecular macrocyclic anions [Hg8Te16]8− (1), the heaviest known topological relative of porphyrin. [Hg8Te16]8− differs from porphyrin by the absence of an electronic π‐system, which prevents a “global” aromaticity. Quantum chemical studies reveal instead small ring currents in the pyrrole‐type five‐membered rings that indicate weak local (σ) aromaticity. As a result of their lamellar nature, the compounds are promising candidates for the formation of sheets containing chalcogenidometalate anions.
Real‐Time Probing of Nanowire Assembly Kinetics at the Air–Water Interface by In Situ Synchrotron X‐Ray Scattering
Authors: He Zhen , Jiang Hui‐Jun , Wu Long‐Long , Liu Jian‐Wei , Wang Geng , Wang Xiao , Wang Jin‐Long , Hou Zhong‐Huai , Chen Gang , Yu Shu‐Hong 
Published: May 2018

AbstractAlthough many assembly strategies have been used to successfully construct well‐aligned nanowire (NW) assemblies, the understanding of their assembly kinetics has remained elusive, which restricts the development of NW‐based device and circuit fabrication. Now a versatile strategy that combines interfacial assembly and synchrotron‐based grazing‐incidence small‐angle X‐ray scattering (GISAXS) is presented to track the assembly evolution of the NWs in real time. During the interface assembly process, the randomly dispersed NWs gradually aggregate to form small ordered NW‐blocks and finally are constructed into well‐defined NW monolayer driven by the conformation entropy. The NW assembly mechanism can be well revealed by the thermodynamic analysis and large‐scale molecular dynamics theoretical evaluation. These findings point to new opportunities for understanding NW assembly kinetics and manipulating NW assembled structures by bottom‐up strategy.
One‐inflation and unobserved heterogeneity in population size estimation by Ryan T. Godwin
Authors: Inan Gul 
Published: May 2018

AbstractIn this study, we would like to show that the one‐inflated zero‐truncated negative binomial (OIZTNB) regression model can be easily implemented in R via built‐in functions when we use mean‐parameterization feature of negative binomial distribution to build OIZTNB regression model. From the practitioners' point of view, we believe that this approach presents a computationally convenient way for implementation of the OIZTNB regression model.
Rapid LC–MS/MS method for quantification of vinorelbine and 4‐O‐deacetylvinorelbine in human whole blood suitable to monitoring oral metronomic anticancer therapy
Authors: Corona Giuseppe , Gusella Milena , Gaspardo Anna , Miolo Gianmaria , Bertolaso Laura , Pezzolo Elisa , Pasini Felice , Steffan Agostino , Caruso Donatella 
Published: May 2018

AbstractA rapid and sensitive LC–MS/MS method for therapeutic drug monitoring oral vinorelbine (VRL) metronomic anticancer chemotherapy has been developed and validated. Analysis of VRL and its main active metabolite 4‐O‐deacetylvinorelbine (M1) was performed in whole blood matrix. Both analytes were extracted by protein precipitation and separated on an Onyx monolith C18, 50 × 2 mm column then quantified by positive electrospray ionization and multiple reaction monitoring mode. The LLOQ was 0.05 ng/mL for both VRL and M1. Linearity was up to 25ng/mL with R2 ≥ 0.994. The intra‐ and inter‐assay precisions were ≤ 11.6 and ≤ 10.4% while the ranges of accuracy were [−8.7%; 10.3%] and [−10.0; 7.4%] for VRL and M1, respectively. The clinical suitability of the method has been proved by the determination of the CTrough blood concentrations of VRL and M1 in 64 nonsmall cell lung cancer elderly patients. The analytical performance of the assay was suitable for pharmacokinetic monitoring of VRL and M1, allowing the personalization of the VRL metronomic treatments.
Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically‐developing peers: A comparison and validation study
Authors: Howsmon Daniel P. , Vargason Troy , Rubin Robert A. , Delhey Leanna , Tippett Marie , Rose Shannon , Bennuri Sirish C. , Slattery John C. , Melnyk Stepan , James S. Jill , Frye Richard E. , Hahn Juergen 
Published: May 2018

AbstractAutism spectrum disorder (ASD) is a developmental disorder which is currently only diagnosed through behavioral testing. Impaired folate‐dependent one carbon metabolism (FOCM) and transsulfuration (TS) pathways have been implicated in ASD, and recently a study involving multivariate analysis based upon Fisher Discriminant Analysis returned very promising results for predicting an ASD diagnosis. This article takes another step toward the goal of developing a biochemical diagnostic for ASD by comparing five classification algorithms on existing data of FOCM/TS metabolites, and also validating the classification results with new data from an ASD cohort. The comparison results indicate a high sensitivity and specificity for the original data set and up to a 88% correct classification of the ASD cohort at an expected 5% misclassification rate for typically‐developing controls. These results form the foundation for the development of a biochemical test for ASD which promises to aid diagnosis of ASD and provide biochemical understanding of the disease, applicable to at least a subset of the ASD population.
Rhenish Lignite – Energy Carrier and Versatile Raw Material through the Ages
Authors: Overhoff Urs , Moser Peter , Elsen Reinhold , Vinzelberg Gero , Eyll‐Vetter Michael , Neuroth Markus 
Published: May 2018

AbstractAs Germany's most important, domestic fossil energy carrier, lignite plays a crucial role in electricity and heat production. Even though its share of the overall power production is decreasing due to a rising feed‐in from renewable energy sources, fossil energy carriers will go on providing base load and back‐up electricity in times when renewable energies are not able to produce enough electricity. Lignite and byproducts, which are gained during the conversion and exploitation of lignite, can be used for material utilization. The production of hydrocarbons or extraction of important raw materials are examples. It is expected, that this field of application will gain relevance in the future.
Dipeptidyl peptidase‐4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance
Authors: Nephan Gulay , Coskun Zeynep Mine , Bolkent Sema 
Published: May 2018

The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase‐4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male adult Sprague‐Dawley rats (n = 32) were divided into 4 groups: control (Ctrl), IR, saxagliptin control, and IR treated with saxagliptin(IR + S). Insulin resistance was induced by 10% fructose in the drinking water for 8 weeks. Saxagliptin (10 mg/kg/day) was administrated by oral gavage for 2 weeks. Biochemical parameters were measured spectrophotometrically. Peptides were determined by the streptavidin‐biotin‐peroxidase method. Although the amount of food and liquid consumed are inversely proportional, the calories received are almost equal between both Ctrl and IR groups, as well as IR and IR + S groups. Increased homeostasis model assessment for insulin resistance, HOMA‐β, triglycerides, and very low‐density lipoprotein in the IR group were comparatively decreased by saxagliptin administration. The area percentage of caspase‐3 and apoptotic peptidase activating factor‐1 immunopositive cells in the IR + S group decreased compared with the IR group. Similarly, the percentages of caspase‐8 and ‐9 immunopositive cells in the IR group were higher than the IR + S group. It was observed that the percentage of poly (ADP‐ribose) polymerase‐1 immunopositive cells was increased in the IR + S group compared with the IR group. Thus, saxagliptin may prevent IR‐induced apoptotic cell death and regulate impaired homeostasis model assessment for insulin resistance and serum lipid levels.
A Degradable and Recyclable Photothermal Conversion Polymer
Authors: Xu Xiao‐Qi , Wang Zhen , Li Ruiting , He Yonglin , Wang Yapei 
Published: May 2018

AbstractDecomposition and repolymerization of conjugated polymers offer great promise for developing recyclable photothermal conversion materials, which yet remain challenging. Herein, a crosslinked conjugated polymer based on a dynamic covalent bond of Schiff base is developed. This polymer possesses photothermal conversion efficiency as high as 90.4 %. Decomposition of the polymer under specialized conditions is corroborated by various characterizations. The kinetics study is also investigated to understand this degradation process. Furthermore, those decomposed species can be repolymerized back to conjugated polymers which possess the same photothermal conversion efficiency as the pristine polymer. Such a degradable and recyclable photothermal polymer is successfully used as a heat source for photothermal‐electrical conversion to generate Seebeck voltage under either near infrared (NIR) irradiation or solar illumination.
A Trichromatic and White‐Light‐Emitting MOF Composite for Multi‐Dimensional and Multi‐Response Ratiometric Luminescent Sensing
Authors: Dai Yue , Zhang Jian‐Jun , Liu Shu‐Qin , Zhou Huajun , Sun Ying‐Ji , Pan Yu‐Zhen , Ni Jun , Yang Jing‐Si 
Published: May 2018

AbstractPresent here is a new dual ratiometric luminescent probe D which is a trichromatic and white‐light‐emitting metal‐organic framework (MOF) composite facilely obtained by incorporating red/green‐emitting complex modules into a blue‐emitting MOF. Probe D exhibits remarkable capabilities of sensing different volatile organic solvents (VOSs) via 2D code recognition of the two VOS‐dependent MOF ligand‐to‐module ratios of the emission‐peak intensities. For specific VOSs, the resultant luminescent color changes from the starting white color are sharp enough to be visible to the naked eye. Remarkably, D can differentiate solution‐phase nitroaromatics and metal ions by recording the evolution of the two ratios during titration processes, enabling an unusual 3D code recognition using the titrant amount as the third dimension for the first time. D also can be used to detect dinoseb, Fe3+ and Al3+ ions quantitatively by analysis of the ratios with detection limits as low as 0.050, 0.41, and 0.12 ppm, respectively. Clearly, such a self‐referencing trichromatic probe can maximize the output information and significantly enhance the detection selectivity and sensitivity via multi‐dimensional sensing, and has great potentials for practical applications.
Dimerization of the Benzyl Radical in a High‐Temperature Pyrolysis Reactor Investigated by IR/UV Ion Dip Spectroscopy
Authors: Hirsch Florian , Constantinidis Philipp , Fischer Ingo , Bakels Sjors , Rijs Anouk M. 
Published: May 2018

AbstractInvited for the cover of this issue is the group of Ingo Fischer at the University of Würzburg and of Anouk M. Rijs at the Radboud University. The image depicts polycyclic aromatic hydrocarbons produced in the self‐reaction of the benzyl radical. Benzyl itself is formed in combustion engines from toluene, an anti‐knock additive. Read the full text of the article at 10.1002/chem.201800852.
Cells, cytokines, chemokines, and cancer stress: A biobehavioral study of patients with chronic lymphocytic leukemia
Authors: Andersen Barbara L. , Goyal Neha Godiwala , Weiss David M. , Westbrook Travis D. , Maddocks Kami J. , Byrd John C. , Johnson Amy J. 
Published: May 2018

BACKGROUNDChronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia, with profound disease‐related cellular, humoral, and innate immune suppression. The objective of this study was to study the correlations between stress and disease‐specific, negative prognostic cellular, cytokine, and chemokine markers in patients with CLL.METHODSA single‐group, observational design was used. Patients with relapsed/refractory CLL (N = 96) who were entering a phase 2 trial of an experimental therapy (ibrutinib) were studied. Before the first dose, a validated self‐report measure of stress (the Impact of Event Scale) was completed, and blood was drawn for absolute lymphocyte counts (ALCs) and for cytokine and chemokine enzyme‐linked immunosorbent assays. Multiple linear regression models tested stress as a concurrent predictor of ALCs; of cytokines (tumor necrosis factor α [TNFα], a proliferation‐inducing ligand [APRIL], B‐cell activating factor [BAFF], interleukin 6 [IL‐6], IL‐10, IL‐16, and vascular endothelial growth factor [VEGF]); and of the chemokine (C‐C motif) ligand 3 (CCL3).RESULTSControlling for relevant demographic variables, comorbidities, CLL genetic risk (deletion of the short arm of chromosome 17 [del17p]), and correlates of inflammation, stress predicted higher ALCs (P < .05), and higher levels of TNFα (P < .05), IL‐16 (P < .01), and CCL3 (P < .05). Stress was not associated with APRIL, BAFF, IL‐6, IL‐10, or VEGF.CONCLUSIONSNovel biobehavioral data from patients with relapsed/refractory CLL demonstrate that stress is related to heightened levels of cellular, cytokine, and chemokine markers associated previously with progressive disease in CLL. The current results indicate that stress is related to immune and inflammatory processes that contribute to cancer cell proliferation and survival. These data provide a first look into these processes. Cancer 2018. © 2018 American Cancer Society.