bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying miRNA synergism using multiple-intervention causal inference
Authors: Zhang Junpeng , Pham Vu Viet Hoang , Liu Lin , Xu Taosheng , Truong Buu , Li Jiuyong , Rao Nini , Le Thuc Duy 
Published: May 2019

AbstractBackgroundStudying multiple microRNAs (miRNAs) synergism in gene regulation could help to understand the regulatory mechanisms of complicated human diseases caused by miRNAs. Several existing methods have been presented to infer miRNA synergism. Most of the current methods assume that miRNAs with shared targets at the sequence level are working synergistically. However, it is unclear if miRNAs with shared targets are working in concert to regulate the targets or they individually regulate the targets at different time points or different biological processes. A standard method to test the synergistic activities is to knock-down multiple miRNAs at the same time and measure the changes in the target genes. However, this approach may not be practical as we would have too many sets of miRNAs to test.ResultsIn this paper, we present a novel framework called miRsyn for inferring miRNA synergism by using a causal inference method that mimics the multiple-intervention experiments, e.g. knocking-down multiple miRNAs, with observational data. Our results show that several miRNA-miRNA pairs that have shared targets at the sequence level are not working synergistically at the expression level. Moreover, the identified miRNA synergistic network is small-world and biologically meaningful, and a number of miRNA synergistic modules are significantly enriched in breast cancer. Our further analyses also reveal that most of synergistic miRNA-miRNA pairs show the same expression patterns. The comparison results indicate that the proposed multiple-intervention causal inference method performs better than the single-intervention causal inference method in identifying miRNA synergistic network.ConclusionsTaken together, the results imply that miRsyn is a promising framework for identifying miRNA synergism, and it could enhance the understanding of miRNA synergism in breast cancer.
Structure of a hyperthermostable dimeric archaeal Rubisco fromHyperthermus butylicus
Authors: Bundela Rudranuj , Keown Jeremy , Watkin Serena , Pearce Frederick Grant 
Published: May 2019

The crystal structure of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) from the hyperthermophilic archaeonHyperthermus butylicusis presented at 1.8 Å resolution. Previous structures of archaeal Rubisco have been found to assemble into decamers, and this oligomerization was thought to be required for a highly thermally stable enzyme. In the current study,H. butylicusRubisco is shown to exist as a dimer in solution, yet has a thermal denaturation midpoint of 114°C, suggesting that high thermal stability can be achieved without an increased oligomeric state. This increased thermal stability appears to be due to an increased number of electrostatic interactions within the monomeric subunit. As such,H. butylicusRubisco presents a well characterized system in which to investigate the role of assembly and thermal stability in enzyme function.
Inertia parameter identification of anunknown captured space target
Authors: Liu Xiaofeng , Zhou Bangzhao , Xiao Boyang , Cai Guoping 
Published: May 2019

Purpose
The purpose of this paper is to present a method to obtain the inertia parameter of a captured unknown space target.

Design/methodology/approach
An inertia parameter identification method is proposed in the post-capture scenario in this paper. This method is to resolve parameter identification with two steps: coarse estimation and precise estimation. In the coarse estimation step, all the robot arms are fixed and inertia tensor of the combined system is first calculated by the angular momentum conservation equation of the system. Then, inertia parameters of the unknown target are estimated using the least square method. Second, in the precise estimation step, the robot arms are controlled to move and then inertia parameters are once again estimated by optimization method. In the process of optimization, the coarse estimation results are used as an initial value.

Findings
Numerical simulation results prove that the method presented in this paper is effective for identifying the inertia parameter of a captured unknown target.

Practical implications
The presented method can also be applied to identify the inertia parameter of space robot.

Originality/value
In the classic momentum-based identification method, the linear momentum and angular momentum of system, both considered to be conserved, are used to identify the parameter of system. If the elliptical orbit in space is considered, the conservation of linear momentum is wrong. In this paper, an identification based on the conservation of angular momentum and dynamics is presented. Compared with the classic momentum-based method, this method can get a more accurate identification result.
Abandon canon in American sociology
Authors: Au Anson 
Published: May 2019

PurposeThe purpose of this paper is to challenge the practice of having, using and constructing any canon in sociological theory. This paper argues that the elitism of American sociology and the forms of inequality it engenders are sustained by the construction of a canon itself.Design/methodology/approachThis paper adopts a conceptual approach to examine the problems of research practice, academic writing, inequality and empirical translation that canonical thinking engenders within the academy and beyond.FindingsReflecting on the problems outlined, this paper articulates a more democratic agenda for treating canon in research and education by drawing upon standards of practice in ethnography, participatory action research and Southern Theory.Originality/valueThis paper interrogates the relations of domination that remain at work in the discipline and that which concern the elite position of American sociology itself.
Social networks, accessed and mobilised social capital and the employment status of older workers
Authors: Gayen Kaberi , Raeside Robert , McQuaid Ronald 
Published: May 2019

Purpose
The purpose of this paper is to demonstrate the importance of social networks, and the social capital embedded in them, to secure employment if someone had become unemployed after the age of 50 years and to reveal the process of accessing and mobilising that social capital.

Design/methodology/approach
A case study of a Scottish labour market was undertaken which involved an interview-based survey of those who became unemployed in their early 50’s and tried to regain employment. The interview had structured and unstructured parts which allowed both quantitative and qualitative analysis to compare those who were successful in regaining work with those who were not. The uniqueness of the paper is the use of social network components while controlling for other socio-economic and demographic variables in job search of older workers.

Findings
Those older people who were unemployed and, returned to employment (reemployed) had a higher proportion of contacts with higher prestige jobs, their job searching methods were mainly interpersonal and the rate of finding their last job via their social networks was higher than those who remained unemployed. Both groups mobilised social capital (MSC), but those reemployed accessed higher “quality” social capital. “Strong ties”, rather than “weak ties”, were found to be important in accessing and mobilising social capital for the older workers who returned to employment.

Research limitations/implications
This work is limited to a local labour market and is based on a small but informative sample. However, it does show that policy is required to allow older people to enhance their social networks by strengthening the social capital embedded in the networks. The results support the use of intermediaries as bridges to help compensate for older people who have weak social networks. Besides the policy implications, the paper also has two distinct research implications. First, the use of social network component to the existing literature of older workers’ job search. Second, exploring the type and relational strength with network members to explain older workers’ reemployment.

Practical implications
The paper illustrates that how accessed and MSC can be measured.

Social implications
As populations age, this work points to an approach to support older people to re-enter employment and to include them in society.

Originality/value
The paper extends social network and employment literature to fill gaps on how older people require to both access and mobilise social capital. The importance of “strong ties” in the reemployment of older workers contrasts with much of the literature on younger workers where the “strength of weak ties” so far has been regarded as essential for successful job search. Measures are forwarded to reveal the relevance of social capital. The policy value of the work is in suggesting ways to facilitate older people re-enter or remain in work and hence sustain their well-being.
Differences in organization citizenship behavior between “serumpun” countries (Indonesia – Malaysia)
Authors: Suharnomo Suharnomo , Hashim Fathyah 
Published: May 2019

Purpose
This paper aims to examine the effect of job motivation and commitment on organizational citizenship behavior (OCB) of Indonesian and Malaysian employees. Organizational and national cultures are introduced as moderators and OCB as a mediator to investigate their relationships in the context of job performance.

Design/methodology/approach
The sample was drawn from employees using a purposive sampling method. A total of 264 valid questionnaires were obtained from employees. The data were analyzed using regression analysis.

Findings
The results show that job commitment and job motivation positively affect OCB in Indonesia but not Malaysia. The results also reveal that job motivation affects OCB in both countries. In Indonesia, organizational culture and national culture partially moderate the influence of job commitment and motivation on OCB, except the commitment to the organization's culture. However, roles of these moderators in job commitment and motivation are not evident in Malaysia. The result of this study also shows that OCB affects performance in Malaysia but not Indonesia.

Practical implications
The results of this study can be used to explore Indonesian and Malaysian employees. Although the culture of these two countries is originated from the same roots which cause many similarities among them, there are differences in terms of OCB and employee’s performance that can affect organizational performance and also ways in dealing business with Indonesian and Malaysian companies.

Originality/value
This study is one of the first studies to examine cross-cultural dimensions in two Southeast Asian countries. The findings contribute to the current OCB literature by confirming the roles of OCB and culture in the effects of job motivation and commitment on job performance.
Curvilinear relationship between intra-team trust and team innovation: the moderating role of task complexity
Authors: Hendarsjah Hidajat , Susanto Ely , Lies Sugianto Bambang Riyanto , Handoko Tarsisius Hani 
Published: May 2019

PurposeThis paper aims to identify the relationship pattern between intra-team trust and team innovation and the influence of moderating variable task complexity on the relationship. It also describes why and how intra-team trust is a unique antecedent for team innovation, as too much or too less influence of the variable can have detrimental effects on team innovation.Design/methodology/approachThe paper uses survey research. The data were collected by distributing questionnaires to work teams. After the individual-level data were aggregated into team-level data, hierarchical linier regression was conducted to test the hypotheses.FindingsThe paper provides empirical findings that (1) intra-team trust and team innovation have a curvilinear relationship pattern, (2) task complexity does not influence curvilinear relationship (3) and the increase in task complexity improves the possibility of team innovation to occur.Research limitations/implicationsThe paper has two limitations. First, as intra-team trust was also represented by aggregated perception of team members’ trust for outside parties (not only members’ perception for their teams), the future research is expected to include the representation in the instrument. Second, recent research studies have shown that contextual factor of task interdependence, instead of task complexity, also had an effect on the relationship pattern between intra-team trust and team performance (i.e. team innovation). Therefore, for future researchers, it is suggested that the use of task interdependence would be an alternative moderating variable on the relationship between intra-team trust and team innovation.Practical implicationsThe paper discusses the strategy to enhance team innovation by revealing strategies to manage interplay among intra-team trust, team complexity and the desired team innovation.Originality/valueThe paper identifies the need to conduct empirical research on how an interplay among intra-team trust, task complexity and team innovation could be enabled.
Rethinking on growth mechanism of Indian sugar industry
Authors: Sheetal  , Kumar Rajiv 
Published: May 2019

Purpose
The purpose of this paper is to revisit the growth mechanism of Indian sugar industry by deploying quantitative and qualitative metaphors.

Design/methodology/approach
The research paper has been composed through comprehensive primary research survey using a structured questionnaire, and qualitative discussion following semi- structured interviews with industry professionals on emerging issues across the whole value chain of sugar industry. Respondents regarding primary survey were selected using the purposive sampling, and this collected quantitative information has been verified on the lenses of multiple stream modelling (MSM).

Findings
To support the data analysis, MSM – a policy-making framework has been developed which found that government being a central construct exerts a profound presence across whole value chain; in suppliers’ mechanism, marketing of sugar and sugar mills’ infrastructural expansions. Nationwide uniformity in sugar policy instead of states’ monopolistic policies, rational and mutual benefits-based decisions collectively by the government, mills management and sugarcane growers, and diversification in production processes are enumerated as the proposed solutions against the chronical industry problems.

Practical implications
This study enriches extant Asian sugar industry literature. For policymakers, the proposed results should be of help in identifying specific policies to support the competitiveness of local systems and individual manufacturing companies in the Indian sugar industry suggesting that the development of growth mechanisms can contribute simultaneously to improve the financial, market and operational performance of both individual firms and supply chains.

Originality/value
Cyclicality in production, rising sugarcane farmers’ problems and resulting severe financial distress of mills are some of the topical issues of Indian sugar industry, and the study has explored these issues factually, quantitatively and qualitatively in proximity of industry professionals and described in this depository with the help of document analysis.
Understanding customer-perceived quality in informal stores
Authors: Osakwe Christian Nedu 
Published: May 2019

PurposeAlthough customer-perceived quality (CPQ) has been studied for years, very little is known about the implications of CPQ to informal retail stores particularly in collectivist and high uncertainty avoidance societies like Nigeria. More specifically, this study aims to investigate the indirect implications of CPQ to post-purchase behaviour primarily word-of-mouth (WoM) communication which is even more critical for customer acquisition in the research context. By so doing, it develops a contextualised model in which the emerging concept of commercial friendship (CF) is incorporated to mediate the relationship between CPQ and WoM communication.Design/methodology/approachUsing a survey-based design, data were gathered from 372 informal merchants’ customers. Structural equation modelling technique primarily PLS-SEM (partial least squares structural equation modelling) was used in analysing the data.FindingsThe data confirm that the multifaceted CPQ construct has an important implication for WoM through the mediation of CF. Supplementary analysis reveals that CF fully mediates one of the sub-components of CPQ, namely, personal interaction in relationship to WoM in addition to acting as a partial mediator between store policy, physical aspect and reliability and WoM.Originality/valueThe value of this study is that it draws attention to the special role that CF plays in the investigation of the relationship between CPQ and WoM communication in the research context. Additionally, it is a step towards extending and contextualising research about service quality perceptions and its outcomes in non-traditional Western contexts.
Claimants’ views on total and permanent disability insurance claims
Authors: Black Margaret Elizabeth , Matthews Lynda Roslyn , Millington Michael J. 
Published: May 2019

PurposeThis study aims to investigate Australian claimants’ experience of the total and permanent disability (TPD) insurance claims process and documents their recommendations for improvement.Design/methodology/approachA qualitative methodology was used. In all, 12 claimants with finalized TPD claims were recruited via their superannuation fund. Data collected from in-depth interviews were thematically analyzed and reported using the COREQ checklist. Extracts from verbatim transcription were included to represent the claimant without bias.FindingsMost interviewees described a flawed claims process in which important information was withheld or unclear, procedures were complicated and arduous, communication was poor and frequent need for “chasing up” was frustrating. The claims process undermined the well-being of many interviewees at a critical time in their adjustment to disability. Lump sum payment yielded unexpected consequences for ten interviewees. Some interviewees retained a desire to work despite serious disability.Research limitations/implicationsThe use of purposive sampling means that findings may not represent the experience of all claimants with finalized TPD claims. Saturation of knowledge was reached despite the relatively small number of in-depth interviews conducted. In the absence of previous research, this study identifies areas of concern in the TPD claimant experience and posits a set of important claimant issues for further investigation.Practical implicationsA person-centred approach is needed. Claimants would benefit from introduction of clear process information, a single point-of-contact throughout claim, advocacy/support and rehabilitation.Originality/valueThis inaugural study provides an understanding of challenges faced by TPD claimants. All interviewees provided suggestions for improvement in the TPD claims process.
Insights into VdCmr1‐mediated protection against high temperature stress and UV irradiation in Verticillium dahliae
Authors: Fang Yulin , Klosterman Steven J. , Tian Chengming , Wang Yonglin 
Published: May 2019

SummaryThe fungus Verticillium dahliae causes vascular wilt disease on more than 200 plant species worldwide. This fungus can survive for years in soil as melanized microsclerotia. We found that VdCmr1, a transcription factor, is required for the melanin production and increased survival following UV irradiation in V. dahliae but not for microsclerotia production or virulence. Here, we provided evidence how VdCmr1 protects against high temperature (HT) and UV irradiation in V. dahliae. The results indicate that VdCmr1 mediates entry to the diapause period in V. dahliae in response to HT and contributes to the expression of proteins to minimize protein misfolding and denaturation. VdCmr1 deletion results in the misregulation of DNA repair machinery, suggestive of reduced DNA repair capacity following UV irradiation and in correlation with the low survival rate of UV‐treated VdCmr1 mutants. We discovered a putative VdCmr1‐dependent gene cluster associated with secondary metabolism and stress responses. We also functionally characterized two VdCmr1‐responsive genes participating in HT and UV response. These results shed further light on the roles of VdCmr1 in protection from HT or UV irradiation, and the additional insights into the mechanisms of this protection may be useful to exploit for more effective disease control.
Finding one's place: emotions and positioning in systemic‐dialogical therapy
Authors: Lini Claudia , Bertrando Paolo 
Published: May 2019

Several psychotherapy and family therapy models emphasise work on emotions, both as emotional awareness and transference analysis. Systemic therapy has developed in time a peculiar emphasis on the therapist's position, and on therapists’ and clients’ reciprocal positioning. In the present article we propose to integrate the dimensions of emotions and positioning through a concept we define as ‘finding one's place’. Finding one's place can be considered as a universal positioning activity of anybody involved in any human interaction, involving different domains: macro‐context, group, mutual relationships, internal dialogue. It entails an integration of these domains through an increased awareness of one's position inside relevant systems, and emotional interaction.Practitioner pointsClinicians usually consider positioning and emotions as separate domains for evaluation and interventionThe integration of the two domains allows a deeper, three‐dimensional view of therapeutic events inside and outside therapeutic sessionsThrough the activity of finding her place, the therapist may reach a better understanding of dilemmas and problems in her clients’ relational livesThe therapist may also gain a better orientation for her clinical work
Structured Decision Making to Meet a National Water Quality Mandate
Authors: Martin David M. , Piscopo Amy N. , Chintala Marnita M. , Gleason Timothy R. , Berry Walter 
Published: May 2019

AbstractWater quality criteria are necessary to ensure protection of ecological and human health conditions, but compliance can require complex decisions. We use structured decision making to consider multiple stakeholder objectives in a water quality management process, with a case study in the Three Bays watershed on Cape Cod, Massachusetts. We set a goal to meet or exceed a nitrogen load reduction target for the watershed and four key objectives: minimizing economic costs of implementing management actions, minimizing the complexity of permitting management actions, maximizing stakeholder acceptability of the management actions, and maximizing the provision of ecosystem services (recreational opportunity, erosion and flood control, socio‐cultural amenity). We used multi‐objective optimization and sensitivity analysis to generate many possible solutions that implement different combinations of nitrogen‐removing management actions and reflect tradeoffs between the objectives. Results show technological advances in controlling household nitrogen sources could provide lower cost solutions and positive impacts to ecosystem services. Although this approach is demonstrated with Cape Cod data, the decision‐making process is not specific to any watershed and could be easily applied elsewhere.