bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamma Knife surgery targeting the resection cavity of brain metastasis that has progressed after whole-brain radiotherapy
Authors: Kim Paul K. , Ellis Thomas L. , Stieber Volker W. , McMullen Kevin P. , Shaw Edward G. , McCoy Thomas P. , D'Agostino Ralph B. , Bourland J. Daniel , deGuzman Allan F. , Ekstrand Kenneth E. , Raber Michael R. , Tatter Stephen B. 
Published: November 2018

ObjectSalvage treatment of large, symptomatic brain metastases after failure of whole-brain radiotherapy (WBRT) remains challenging. When these lesions require resection, there are few options to lower expected rates of local recurrence at the resection cavity margin. The authors describe their experience in using Gamma Knife surgery (GKS) to target the resection cavity in patients whose tumors had progressed after WBRT.MethodsThe authors retrospectively identified 143 patients in whom GKS had been used to target a brain metastasis resection cavity between 2000 and 2005. Seventy-nine of these patients had undergone WBRT prior to resection and GKS. The median patient age was 53 years, and the median prescribed dose was 18 Gy (range 8–24 Gy), with resection cavities of relatively larger volume (> 15 cm3). The GKS dose was prescribed at the 40 to 95% isodose contour (mode 50%).Local recurrence within 1 cm of the treatment volume occurred in four (5.1%) of 79 cases. The median duration of time to local recurrence was 6.1 months (range 2–13 months). The median duration of time to occurrence of distant metastases following GKS of the resection cavity was 10.8 months (range 2–86 months). Carcinomatous meningitis developed in four (5.1%) of 79 cases. Symptomatic radionecrosis requiring surgical treatment occurred in three (3.8%) of 79 cases. The median duration of survival following GKS of the resection cavity was 69.6 weeks. The median 2- and 5-year survival rates were 20.2 and 6.3%, respectively.Conclusions When metastases progress after WBRT and require resection, GKS targeting the resection cavity is a viable strategy. In 75 (94.9%) of 79 cases, GKS of the resection cavity in patients in whom WBRT had failed appears to have achieved its goal of local disease control.
Volumetric follow up of brain metastases: a useful method to evaluate treatment outcome and predict survival after Gamma Knife surgery?
Authors: Feigl Guenther Christian , Horstmann Gerhard A. 
Published: November 2018

ObjectBrain metastases are diagnosed in 20 to 40% of all cancer patients and are associated with a considerable drop in life expectancy and often also in quality of life for these patients. Several treatment options are available including surgery, chemotherapy, whole-brain radiotherapy, stereotactic radiotherapy, stereotactic radiosurgery, and Gamma Knife surgery (GKS). However, management of brain metastases still presents a challenge and there is no general consensus on the best treatment strategy. The aim of the authors' study was to further evaluate the efficacy of GKS in the treatment of brain metastases and to evaluate the predictive value of volumetric tumor follow-up measurement.MethodsConsecutive patients with controlled systemic cancer and variable numbers of brain metastases were included in this prospective study. Patients with severe symptoms of brain compression underwent surgery before GKS. Each follow-up examination included a thorough neurological examination and a neuroradiological quantitative volumetric tumor analysis.A total of 300 consecutive patients (mean age 58 years) with 703 brain metastases were treated between December 1998 and October 2005. The mean total tumor volume (TTV) was 2.1 cm3. The overall local tumor control rate was 84.5%. In 79% of all treated metastases a mean TTV reduction of 84.7% was achieved using a mean prescription dose of 21.8 Gy. Only few, mostly mild, side effects were observed during the mean follow-up period of 12.7 months. The overall mean progression-free survival period was 9.4 months. There was a statistically significant difference in survival of patients with one compared with multiple metastases, regardless of the histological type and preceding treatment.Conclusions Gamma Knife surgery is a safe and effective treatment for patients with brain metastases regardless of the history of treatment and histological tumor type. It achieves excellent tumor control, significant TTV reduction without causing severe side effects, and accordingly, preserves quality of live. Volume changes after GKS did not serve as a predictor for treatment outcome and survival.
Statistical Analysis of the Performance of a Big and Open Economy: The Case of the U.S.
Authors: Zhuravliov O. V. , Simachova О. М. 
Published: November 2018

The US economy is one of the richest and most diversified economies in the world and keeps its leadership in the global economy for the past 100 years. The United States is a global leader in computer technology, pharmaceuticals and the manufacture of medical, aerospace and military equipment. And although services make up about 80% of GDP, the US remains the second largest producer of industrial goods in the world and is a leader in research and development.
President Donald Trump was elected in November 2016, promising a big gap with his predecessor’s regulatory, tax and trade policies. Therefore, the current socio-economic status of the USA and the possible ways of its development in the future are interesting for studying the impact on other economies, in particular, on the Ukrainian economy and the search for new and optimal ways of developing relations between the United States and Ukraine.
Key macroeconomic indicators of the US economy in 2011–2018 are analyzed, demonstrating the influence of Donald Tramp’s new policy on changes in the indicators of the economy, the labor market, trade, etc., as well as possible ways of development in the coming years. The review of key macroeconomic indicators gives grounds for classifying the American economy as healthy one. Rates of GDP growth will remain in the range of 2 to 3%. These rates of growth in the world’s largest economy are callable to ensure a substantial increase in the global activity. But uncertainties in the politics may hinder global growth and have clearly negative impact on the investment growth in developed and developing economies.
Primary Accounting of Non-Current Assets Held for Sale
Authors: Shygun M. М. , Mychak N.O. 
Published: November 2018

The article is devoted to the study of the documentary support for operations with non-current assets held for sale. The importance of the study is determined by the fact that in the Ukrainian business accounting and recording practice, information about economic transactions with non-current assets held for sale is recorded in the forms approved for fixed and intangible assets that do not reflect all the aspects of accounting for non-current assets held for sale, which is inappropriate because it does not allow for their rational management and control. Despite the judiciousness of studies on recording of transactions with non-current assets, recording of transactions with non-current assets held for sale needs further studies because it is not sufficiently developed nowadays.
Absence of special documentary support for accounting of non-current assets held for sale is emphasized. The article’s aim is to develop recommendations for improving the documentary support for transactions with non-current assets held for sale taking into account the economic substance and legal specifics of such transactions.
The authors propose a form of the Act on reclassification of non-current assets into non-current assets held for sale, which can provides a substantiated documentary confirmation of the execution of such transactions. This form takes into consideration all the necessary information about recognition of an asset as one held for sale.
The authors’ recommendations are given. In order to improve the recording of transactions with non-current assets held for sale, the primary documents should be issued not only at the moment of such assets reclassification, but also prior to their reclassification from non-current assets into non-current assets held for sale, and in the period of holding them for sale till the moment of transfer to the buyers.
Registration and Blocking of Tax Bill / Calculation of Adjustments: New Rules for Business and Fiscal Officers
Authors: Yurchenko O. А. , Svyryda О. А. 
Published: November 2018

Implementation of the system for administering value added tax for the domestic business sector was an IMF requirement. However, its applications by business entities could not eliminate “tax heavens”, barter deals and purchase (sale) of doubtful tax credit. It was in 1 July 2017 that the system for computerized monitoring of the conformity of tax bills (TB) / calculation of adjustment (CA) to the risk assessment criteria sufficient to stop registration of such TB / CA in the Single Register of Tax Bills was launched. The article’s objective is to form the authors’ vision of the essence of the problem related with registration and blocking of TB and CA in the Single Register of Tax Bills.
The following aspects are covered by the analysis: the nomenclature of indicators checked in TB / CA deciphered upon coming to the State Fiscal Service of Ukraine; the types of receipts on the results of computerized check, intended for VAT payers; the detailed list of criteria for exclusion of TB / CA from the monitoring by the State Fiscal Service of Ukraine (once these criteria are not met, TB / CA is to become subject to monitoring and check for the riskiness of taxpayer and its operations, i. e. the criteria of fictitious business); the indicators of the positive story of a taxpayer. The issues of identifying the taxpayer risks that can be subject to scrutiny by the State Fiscal Service are highlighted. The criteria determining the positive tax story of a taxpayer are given.
It is concluded that all the TB and CA submitted for registration in the Single Register of Tax Bills are to be checked for the conformity to three legally defined essential criteria; once TB / CA does not meet these criteria, they will be subject to monitoring and check for conformity with the criteria of riskiness of taxpayer and operations and the indicators of positive taxpayer story. The positive taxpayer story can rescue a VAT payer from blocking of its TB / CA that meet the riskiness of operation criterion. But once a taxpayer gets on the list of risky business entities, registration of its TB / CA will always be blocked.
Assessment of the Risks of the Continuity, Related with Business Environment of a Business Entity
Authors: Selishchev S. V. 
Published: November 2018

The article contains research and further development of approaches to the assessment of the risks of continuity of business-related business activities of an entity. Particular attention is devoted to the assessment of the size of audit risk for groups of events or conditions that, individually or collectively, can potentially challenge the ability to assume continuity of activities.
The peculiarities of the business environment and the accounting system of business entities impose a certain imprint on the methodology of carrying out the audit procedures for assessing the risk of material distortion of financial data in accounting, in terms of determining the correct application of the principle of continuity by management personnel. Thus, it should be noted that enough attention should be paid to the auditor’s actions in obtaining an understanding of the nature and main features of accounting processes related to their presentation in accounting registers and reporting, including the system of internal control, to the extent that is sufficient for identification and evaluation risks of termination of activities caused by management policies, fraud or mistake.
Actuality in this sense is being acquired by research aimed at further development and adaptation of the general scientific approaches, elucidated in the works of domestic and foreign scientists to assess the risks of continuity of the enterprise related to the business environment of the entity.
The purpose of the article is to study and further develop approaches to the assessment of the risks of continuity of business-related business environment of the entity.
Taking into account the results of the conducted research of the application of the standard method of assessment of audit risk, it was concluded that differentiation of the influence of the factors of changes in the level of audit risk is made. When conducting audit procedures to determine the level of risk of unreasonable use of the assumption of continuity of activities in the preparation of financial statements by management personnel, use standard procedures for the allocation of accounting areas that are subject to an increased level of audit risk and developed recommendations for improving the distribution of components of audit risk according to events or conditions that, individually or collectively, may result in the termination of the entity's activities.
M. Rudenko versus K. Marx: the Ukrainian Exposure of the Senselessness of the Economic Component of Marxism
Authors: Shevchuk V. O. 
Published: November 2018

Evidences denying the argument about humanistic stances of K. Marx are given, and the falseness of the economic component of Marxism and its ideological system as a whole are shown. It is demonstrated that the knowledge enabling the denial of the Marxist verdict to “reactionary classes” and “reactionary nations” takes the roots in the Ukrainian academic community. The essential points of the critique of Marx’s “Capital” by Ukrainian scientist M. Rudenko are given. According to M. Rudenko, Marxist “achievements”, if looked at closely, turn to be but dissected theses of English political economy. The falseness of Marx’s doctrines is in making absolute what is in fact relative. From the A. Smith’s theory he extracts but two elements: the labor, made absolute and put above the nature, with the invented “social substance” as the source for additional value, and the clear-cut break of the society into classes.
Rudenko, as a representative of the academic school of physical economy, offers his own conceptual model of capital by breaking it into absolute and relative one, and showing that the latter derives only from the former. He demonstrates that capital is a value capable of generating an additional value. The categories of capital that he shows can, accordingly, generate an absolute additional value and a relative additional value. In this way, a radically distinct concept of capital and capitalism appears.
It is stressed that the European physiocracy, the Ukrainian academic school of physical economy and the modern physics-economics thought constitutes the fundamental part of the economic knowledge base of the humanity, whereas the political economy (with the Marxist economic component included) has derivative or secondary role.
De las buenas familias del valle de Toluca: los Villanueva. Un ejemplo de la vinculación de la propiedad a través de la institución del Mayorazgo, siglos XVII-XIX
Authors: Barrera Gutiérrez Florencio 
Published: November 2018

En este artículo se examina el proceso del vínculo de una familia y sus propiedades a través de la institución del mayorazgo, desde el siglo XVII hasta la primera mitad del siglo XIX. Se percibirá entonces la trayectoria de una propiedad familiar, de miembros de la naciente elite novohispana, que a lo largo de varias generaciones logran edificar, conservar y aumentar un conjunto de bienes, principalmente agrícolas, en los pueblos de Otzolotepec, Jilotzingo, Mimiapan y Xonacatlán, ubicados en el valle de Toluca. El mayorazgo de Villanueva, cuyo apellido familiar dio nombre, no fue excesivamente productivo, sino que correspondía a una familia de la nobleza que, con esfuerzo y dedicada labor, y aun con problemas a su alrededor, perpetuó en muchos sentidos. Así estuvo presente hasta la tercera década del siglo XIX. Durante poco más de doscientos treinta años, se sucedieron, al frente de los destinos del mayorazgo once personajes.
The development of technology of rickot cheese from whey, obtained using various coagulants
Authors: Tsisaryk O. Y. , Musiy L. Y. , Slyvka I. M. , Chrystyuk V. 
Published: November 2018

The problem of obtaining and rational use of whey proteins in human nutrition today is solved all over the world, traditional methods are being improved and new, more effective ways of processing milk whey, aimed at maximizing the withdrawal and use of its proteins, are being developed. The aim of the research was to develop the technology of albumin cheese ricotta from serum derived by the action of various coagulants. The raw material for cheese production was serum. For the study, two samples of cheese (with a threefold repetition) were made: Sample 1 - using serum formed during the fermentation of proteins with the participation of citric acid (normalized mixture + enzyme + citric acid); Sample 2 – using serum formed during protein mixing with the direct introduction of the fermentation culture (normalized mixture + enzyme + culture + calcium chloride). Determination of organoleptic and physico-chemical parameters in samples of albumin cheese, obtained from the developed technology, was carried out immediately after manufacture. The study of organoleptic characteristics of cheeses showed a similarity of indicators in samples 1 and 2. In particular, it was stated that pure, fresh taste and smell, with a specific albumin flavor, without foreign flavors and odors. Consistency in 1 sample was homogeneous, creamy, in 2 samples it was tender, but with a slight splinting. The color of the cheeses was white uniform throughout the mass. The lower acidity in the sample 2, which was at 17 °T, whereas in the sample 2 was higher – 20 °T. This, in particular, is explained by the use of citric acid for coagulation. The changes of microbiological parameters in the raw materials during storage, which consisted in the growth of the number of mesophilic anaerobic and optional aerobic microorganisms in two samples of cheese, were established. Given the permissible level of the number of mesophilic anaerobic and optional aerobic microorganisms in cheese not more than 1 × 105 CFU/g, the shelf life of two samples of cheese for 5 days. Indicators of titrated acidity during storage were correlated with changes in the number of mesophilic anaerobic and optional aerobic microorganisms. The mass fraction of moisture in the samples of cheese in the process of their storage decreased.
The development of technology of dairy-vegetative dessert with functional additives
Authors: Telezhenko L. , Bilenka I. , Zolovska O. , Lazarenko N. 
Published: November 2018

The article component composition of creamy dessert with whipped consistence on the basis of cottage cheese using alternative plant raw materials – chufa and Jerusalem artichoke tubers or honey was established and proved. This allowed to obtain finished product with low glycemic index. The possibility of using the chufa is shown (earth almond), as a carrier of mono- and polyunsaturated fatty acids (which make up about 82% of the total content), allows to receive desserts with recommended composition of fatty acids. It is shown that preliminary processing of chufa to finely ground semi-product is advisable for its uniform distribution through the dessert volume and formation of its homogeneous whip consistence. A comprehensive two-stage method for chufa preprocessing is developed, which allows to provide products with necessary technological and organoleptic properties. These studies considered for selection of scientifically sound processing modes Cyperus esculentus L. According to the research was the method of cleaning Cyperus esculentus L. Crushed Cyperus esculentus L. recommended for further use in desserts. It is shown that applying of artichoke processing to candied fruits is appropriate for provision of the necessary properties of artichoke flavor while maintaining preventive properties of fructooligosacharides of tubers. A new technological approach for producing candied fruits is developed, which yielded a product with a reduced content of mono-and disaccharides, if the inulin of raw materials is preserved. The model of technological system of milk and vegetable dessert making is developed, which allows developing qualitative principle technological schemes of production of dessert with functional additives. The recipe composition and principal technological scheme of production of dairy-vegetative desserts are developed. The influence of technological factors and recipe composition on rheological, microbiological and organoleptic quality of desserts is observed. The article analyzes the nutritional value of dessert with functional additives. The regulatory documentation is developed. New technologies are implemented in restaurant enterprises.
Strategi Optimalisasi Program Penanggulangan Kerentanan Kemiskinan (Studi Kasus Program Jalinmatra PK2 di Desa Ngroto Kecamatan Pujon Kabupaten Malang)
Authors: Kurniawan Yudiyanto Tri 
Published: November 2018

Program Jalinmatra Penanggulangan Kerentanan Kemiskinan (PK2) dilaksanakan Pemerintah Provinsi Jawa Timur untuk meningkatkan ketahanan ekonomi rumah tangga rentan miskin dalam bentuk pinjaman murah melalui Badan Usaha Milik Desa (BUMDes), salah satu penerimanya adalah Desa Ngroto yang dimulai Juni 2016. Karena sudah lebih dari satu tahun maka perlu dievaluasi pelaksanaannya dan dampaknya, selanjutnya dirancangkan strategi untuk mengoptimalkannya. Kita menggunakan metode penelitian kualitatif deskriptif, melalui wawancara mendalam, kuisioner, dokumentasi dan observasi lapangan. Hasilnya dapat disimpulkan bahwa untuk mengoptimalkan program ini mereka perlu bantuan untuk penguatan permodalan, teknologi, informasi perdagangan, manajeman usaha dan bantuan jaringan profesional.
MODEL PEMBELAJARAN ANTAR-LEVEL PADA CREDIT UNION BEREROD GRATIA
Authors: Elu Wilfridus B. 
Published: November 2018

This case study is intended to describe the inter-level learning process at the Bererod Gratia Credit Union (CUBG) Jakarta and its characteristics based on the concept of inter-level learning in the organization and oriented to the strategic renewal developed by Crossan, Lane, and White (1999), which are learning between individual, group, and organizational levels through 4I: Intuiting, Interpreting, Integrating, Institutionalizing. Also described are the implications of organizational learning on corporate governance. The study was conducted on learning in solving problems of negative results case in the Bintaro Service Place (TP) and loan decisions that must involve the Head Office. Key informants consist of credit staff, Head of Office, and Committee members at Bintaro TP and General Manager at Head Office. The results show that the inter-level learning process in CUBG has a dynamic balance between learning for innovation and change (exploration) with learning for standardization for management certainty (exploitation). Learning is also holistic and includes single-loop learning to triple-loop learning. One important implication of corporate governance is the increasingly entrenched culture of check and balances at various levels of the organization. Communication centrality in learning requires the development of generative change capabilities at every level of the organization to ensure the continuity of transformation is in balance with the development of governance to maintain organizational integrity.Keywords: Organizational Learning; Inter-level Learning, Corporate Governance