bluuebunny/crossref_metadata_2025_split huggingface dataset:
Portobiliary Fistula in a Liver Transplant Recipient Treated With an Endoscopically Deployed Fully Covered Self-Expandable Biliary Metal Stent
Authors: Murray Fritz , Buetikofer Simon , Dutkowski Philipp , Gubler Christoph 
Published: May 2019

ABSTRACT
Biliary complications following liver transplantations, with leaks and bile duct strictures being the most common ones, are greatly feared. Portobiliary fistulas are rare, but may cause potentially life-threatening complications. The presented case shows the first successful treatment of a portobiliary fistula by an endoscopically deployed fully covered self-expandable metal stent after liver transplantation. In accordance to the already established use in refractory bile leaks, we believe that fully covered self-expandable metal stent is a safe and efficient treatment option for portobiliary fistula.
A Curious Case of Coil-Angitis
Authors: Beard Jasna I. , Murphy Sharif , Philips George 
Published: May 2019

ABSTRACT
A 43-year-old man with a history of pedestrian-truck collision 18 months prior presented with right-sided abdominal pain and chills. His trauma consisted of orthopedic injuries and a grade 4 liver laceration. Surgical liver repair was complicated by a biloma requiring common bile duct stenting. Postendoscopy hemobilia led to extensive coiling of a hepatic artery pseudoaneurysm. Remaining hospitalization was relatively uneventful, and he was lost to follow-up. Repeat presentation was marked by leukocytosis and obstructive transaminitis. Computed tomography raised concern for a dilated 14-mm common bile duct with migrated coil mass near the pancreatic head. The patient underwent urgent endoscopic retrograde cholangiopancreatography with cholangioscopy and successful removal of a coil mass measuring approximately 4 × 3 cm without injury to the common bile duct or vascular structures. His pain was relieved, and he was discharged with a common bile duct stent and outpatient follow-up.
Resuturing of Stomach in Endoscopic Sleeve Gastroplasty 8 Months After Original Procedure
Authors: Galvão Neto Manoel dos Passos , Silva Marco , Grecco Eduardo , de Souza Thiago Ferreira , Baldim Luana Leite , Teixeira André , Gomes Sara , Macedo Guilherme , de Quadros Luiz Gustavo 
Published: May 2019

ABSTRACT
Endoluminal treatments such as endoscopic gastroplasty have been gaining ground in obesity treatment. A 52-year-old woman gained weight 5 months after endoscopic gastroplasty. Thus, it was decided to resuture the greater curvature of the stomach 8 months after the initial procedure by reducing the gastric pouch even further. The patient lost 16% of her total body weight with this procedure. Endoscopic gastroplasty, which can be reperformed in patients who regain weight, reach a plateau, or do not achieve the initial planned weight loss, is an effective and safe first-line obesity treatment.
Allelic polymorphisms of thymidylate synthase gene and their haplotypes as predictors of the therapeutic response to methotrexate in patients with rheumatoid arthritis
Authors: Devald I. V. , Khodus E. A. , Khromova E. B. , Nesmeyanova O. B. , Burmistrova A. L. 
Published: May 2019

Methotrexate (MT) is recognized as the main component of the treat to target strategy in patients with rheumatoid arthritis (RA). Unfortunately, MT therapy is not equally effective in all patients with RA, some of them are resistant to such treatment, and have steady progression of destructive changes of the joints, reducing quality of life and leading to disability.Objective: examination of genetic predictors of therapeutic efficacy and resistance to MT among single-nucleotide polymorphisms (SNP) of folate cycle genes, in particular polymorphisms of the thymidylate synthase gene TSER 2R/3R and TS 6bp del/ins and their haplotypes.Subjects and methods. The study included 85 patients with RA, who were prescribed MT at a dose of 10 to 17.5 mg/week as a the «first line» disease-modifying antirheumatic drug. The therapeutic response was evaluated with DAS28 after 6 months of continuous treatment. According to the results of this assessment groups of «respondents» and «non-respondents» to MT were identified. Genetic typing of SNP TSER 2R/3R and TS 6bp del/ins was performed by real-time polymerase chain reaction.Results and discussion. In RA patients with different efficacy of MT, statistically significant differences in the frequency of alleles and genotypes of polymorphic variants of the gene thymidylate synthase were revealed. Thus, in patients resistant to MT homozygous genotype TS 6bp ins/ins frequency was significantly increased (OR 4,3; 95% CI of 1.58 to 11.7; p=0.003), whereas response to the treatment was associated with occurrence of TS 6bp allele del (HR OF 0.48; 95% CI of 0.23 to 1.0; p=0.049), of TSER 2R/3R (OR 0,32; 95% CI 0,12–0,88; p=0.042) and TS 6bp del/ins (OR 0.23; 95% CI 0.08–0.65; p=0.008) genotypes. We have not established statistically significant differences in the frequency of occurrence of haplotypes of the thymidylate synthase gene in RA patients with different therapeutic efficacy of MT, but we found a tendency to increase of the haplotype TS 3R-6bp del (OR 0.39; 95% CI 0.24–1.09; p=0.081) frequency in the «respondents» to the treatment.Conclusion. Our results may indicate the relationship of the thymidylate synthase gene single nucleotide polymorphisms with therapeutic response to MT in patients with RA.
Analysis of Engine Oils from Farm Tractors in the Aspect of their Change
Authors: Gołębiowski Wojciech , Zając Grzegorz , Wolak Artur 
Published: May 2019

Abstract
The paper presents results of research on selected physico-chemical parameters of engine oils from farm tractors based on the date of their change assumed by the user. 17 samples of used engine oil from farm tractors of various producers and with a varied exploitation course were analysed. Oils for research were collected during oil change, registering the service life of oil each time. They were obtained from service points that repair farm tractors in the region of Lublin Province. The studies were to verify whether a decision concerning oil change taken by tractor users after specific time of operation of an engine was good. Number of exceedings of the threshold values of parameters of engine oil which are responsible for correct lubrication were the basis for evaluation
Chemical Threats in Thermally Processed Traditional Food and Possibilities of Their Reduction
Authors: Grochowicz Józef 
Published: May 2019

Abstract
The objective of the paper is to review the present state of knowledge on health threats that occur as a result of some thermal processing of food products. Depending on the type and properties of raw materials and conditions of processes, carcinogenic, mutagen and genotoxic substances may be formed out of them, which may be treated as a process contamination. They are produced in processing plants, where their content is obligatorily controlled and organic, as well as in the conditions of food production in gastronomic units and households. The paper emphasises the second area of food processing, in particular, house-holds and popularised grilling processes, where there are no other possibilities of control of the threat level and awareness of people who prepare food and consumers is insufficient. The paper presents the most often occurring hazardous compounds, the most important regulations and admissible limits of consumption, as well as principles of thermal processing in a safe manner, and possibilities of limiting the levels of those substances in products
Multi-Fuel Power Plant as A Element of Back-Up Energy Supply of Farming Facilities
Authors: Korotkov Aleksandr , Palichyn Andrey , Savinykh Petr , Romaniuk Wacław , Borek Kinga , Barwicki Jan 
Published: May 2019

Abstract
Paper presents research concerned utilization of natural gas in a liquid state as a new source of electrical energy generation in country side areas of Russia to use it in a small family farms and bigger agriculture enterprises. The experiment shows that alcohol and gasoline are more expensive products to be a source for electricity generation as a reserve energy supply in agriculture production areas of the country. Introduction of natural gas generator as an alternative fuel makes possible to produce low cost of electrical energy in any part of the country, what gives great potential to alternative energy supply, but especially for agriculture production on small households and also bigger enterprises
Optimisation of Osmotic Dehydration of Plums
Authors: Ponjičan Ondrej , Sedlar Aleksandar , Findura Pavol , Szparaga Agnieszka , Kocira Sławomir 
Published: May 2019

Abstract
The paper presents kinetics of osmotic dehydration of plums in relation to the treatment time and concentration of sucrose solution. The main aim of the study was polyoptimisation of the preservation process, namely selection of optimal parameters of osmotic dehydration processes including changes in selected quality indicators. Defining of optimal conditions of the entire course of preservation may influence limitation of consumption of preserving substances (osmotic substances) and reduction of the energy demand. Based on the research which was carried out, it was found that parameters of osmotic dehydration had a significant impact on mass transfer coefficients and physico-chemical indicators of fruit - along with the increase of concentration of osmotic solution and extension of the time of the process, the increase of the investigated sizes was observed. In the second part of the paper, optimization of the fruit preservation process was performed. The idea of the objective function consisted in minimization of the difference between the expected values of criteria and the values obtained from the experimental results. For the defined scalar optimization criterion an explicit relation between quality and cost of the product was showed.
Systematic design of microscope objectives. Part I: System review and analysis
Authors: Zhang Yueqian , Gross Herbert 
Published: May 2019

Abstract
In the three connected papers, a systematic analysis and synthesis approach for microscope objectives is introduced. To subtract off the hidden assumptions in the historical development of the microscope objective lenses and extract the intrinsic lens modules, a large objective database is implemented including most of the patented systems for standardised applications. Based on the systematic analysis of the database, in Part I, a general review of the development history is given. A systematic classification method is proposed with respect to the five most significant parameters. According to the review and classification, the impacts of applications, manufacture and technology considerations are systematically analysed and summarised. Details of the lens modules will be discussed in Part II, and the synthesis approach utilising the lens modules will be introduced in Part III.
A multicenter study to evaluate harmonization of assays for N-terminal propeptide of type I procollagen (PINP): a report from the IFCC-IOF Joint Committee for Bone Metabolism
Authors: Cavalier Etienne , Eastell Richard , Rye Jørgensen Niklas , Makris Konstantinos , Tournis Symeon , Vasikaran Samuel , Kanis John A. , Cooper Cyrus , Pottel Hans , Morris Howard A. 
Published: May 2019

Abstract

Background
Biochemical bone turnover markers (BTM) are useful tools to assess bone remodeling at the cellular level. N-terminal propeptide of type I procollagen (PINP) has been recommended as a reference marker for bone formation in research studies.

Methods
We describe the results of a multicenter study for routine clinical laboratory assays for PINP in serum and plasma. Four centers (Athens, Greece [GR], Copenhagen, Denmark [DK], Liege, Belgium [BE] and Sheffield, United Kingdom [UK]) collected serum and plasma (EDTA) samples from 796 patients presenting to osteoporosis clinics. Specimens were analyzed in duplicate with each of the available routine clinical laboratory methods according to the manufacturers’ instructions. Passing-Bablok regressions, Bland-Altman plots, V-shape evaluation method and the concordance correlation coefficient for PINP values between serum and plasma specimens and between methods were used to determine the agreement between results. A generalized linear model was employed to identify possible variables that affected the relationship between the methods.

Results
We showed that both EDTA plasma and serum were suitable for PINP determination. We observed a significant proportional bias between Orion radioimmunoassay and the automated methods for PINP (Roche Cobas and IDS iSYS), which both gave very similar results. The multivariate model did not improve the excellent correlation that was observed between the methods.

Conclusions
Harmonization of PINP assays is possible by applying a correction factor or correctly assigning the values of the calibrators. This work will benefit from further collaboration between assays manufacturers and clinical laboratory professionals.
Trueness assessment of HbA1c routine assays: are processed EQA materials up to the job?
Authors: Delatour Vincent , Clouet-Foraison Noémie , Jaisson Stéphane , Kaiser Patricia , Gillery Philippe 
Published: May 2019

Abstract

Background
With the worldwide increase of diabetes mellitus prevalence, ensuring that HbA1c assays are accurate is essential. External quality assessment (EQA) programs enable laboratories to verify that analytical methods perform according to the manufacturers’ specifications. However, assessing trueness requires commutable materials, a property that is rarely characterized for EQA materials.

Methods
The difference in bias approach was used to assess commutability of 26 processed quality control materials for 17 of the most frequently used HbA1c assays. Involved assays included immuno-assays, enzymatic assays, affinity, ion-exchange HPLC boronate affinity HPLC and capillary electrophoresis. The measurements were performed at manufacturers or expert laboratories. Assay trueness was additionally assessed against the IFCC reference measurement procedure using fresh clinical specimens that were distributed to 450 medical laboratories.

Results
Commutability of processed EQA materials was highly heterogeneous and globally insufficient to rigorously assess the trueness of HbA1c assays. Using fresh clinical specimens, mean bias was −0.13 mmol/mol for low HbA1c (34 mmol/mol), between +1.0 and +1.3 mmol/mol for intermediate HbA1c (49 and 58 mmol/mol) and +1.2 mmol/mol for elevated HbA1c (90 mmol/mol).

Conclusions
This study demonstrates that due to insufficient commutability, most processed EQA materials are unsuitable to assess trueness of HbA1c assays and agreement between the different assays. These materials can only provide information on comparability of individual laboratory results with its peers and on assay precision. Using fresh whole blood samples, this study additionally shows that most HbA1c assays are fairly accurate and meet the total allowable error quality target of 5 mmol/mol.
An innovative method for the chemical modification of Carpinus betulus wood: a methodology and approach study
Authors: Bari Ehsan , Jamali Ali , Nazarnezhad Nouredin , Nicholas Darrel D. , Humar Miha , Najafian Mohammad 
Published: May 2019

Abstract
The objective of this research was to evaluate the influence of acetyl and methyl bonds on the physical, mechanical, photochemical and biological resistance properties of hornbeam wood. Carpinus betulus (hornbeam) wood is considered to be a less valuable species due to poor durability. In order to improve its properties, a novel and simple method was applied to modify wood samples. Hence, wood samples were modified by either acetylation or methylation at four treatment levels. Reactions between hornbeam wood and the formalin and acetic acid treatment system were successful as exemplified by increased mass [weight percent gain (WPG)], slightly better compression strength and considerably improved impact bending strength. Furthermore, the biological decay resistance of the treated wood samples increased for all of the treatments.
The Repulsive Other in Tim Crouch’sI, Malvolio(2010)
Authors: Ablett Sarah J. 
Published: May 2019

AbstractDonald Trump famously used Hillary Clinton’s ‘toilet business’ or Marco Rubio’s ‘sweating like a pig’ as talking points in his campaign for the U. S. presidency. He thereby managed to use disgust’s intrinsic link to fear as a catalyst to negatively influence people’s opinion of his opponents. It was a tactic he also successfully used to rally his supporters against groups of people like ‘lying’ journalists or ‘rapist’ Mexicans. The mechanism of dehumanising the Other via association with disgust can be regarded as a dangerous tool of political rhetoric. In times like ours, where political discourse is commonly drenched in emotional hyperbole, it is paramount that we come to understand our emotions and learn how easily they may be hijacked for political purposes; this is especially true for such a seemingly ‘intuitive’ emotion as disgust. In his playI, Malvoliodramatist Tim Crouch gives voice to a Shakespearean character who has become a victim of discrimination via disgust. Crouch turns the perspectives around and allows the audience to see the story from the deplored’s point of view. This paper uses Crouch’s play for an exemplary analysis of the underlying structures of repulsion, and its relation to fear, and investigates the aesthetic possibilities of redemption.
Terror by Candlelight: The Affective Politics of Fear in Tanika Gupta’sLions and Tigers
Authors: Tronicke Marlena 
Published: May 2019

AbstractIn 2017, Tanika Gupta’sLions and Tigerspremiered at London’s candle-lit, neo-Jacobean Sam Wanamaker Playhouse, which, at first glance, seems ill suited to house a play which is set in pre-Partition Bengal and which depicts both rioting mobs and machine gun shootings. This essay looks at the ways in which, contrary to such initial associations, text and performance space supplement each other. In this case, supposedly cosy candlelight and close proximity to the audience engender feelings of fear and anxiety that can be framed with Sara Ahmed’s notion of the ‘affective politics of fear.’ Continuously interwoven with negotiations between the leading figures of the Indian National Congress, Gupta’s play is firmly set in its own historical context. On the other hand, its climate of boiling nationalism and close parallels tojihadmake it equally relevant to the present day. It is because of this contemporaneous historicity that Gupta’s play proves so gripping: through their ostensibly homely seventeenth-century staging, terror and political unrest become all too close to home, and soLions and Tigersis as much a play that uncovers the hidden stories of Indian Partition as it speaks to the here and now.
(Play)Houses of Horror: Addressing the Anxieties of the Housing Crisis
Authors: Birke Dorothee 
Published: May 2019

Abstract
Among the fears rife in contemporary “Insecure Britain”,
This was a header used by the Guardian for a series of articles in 2014, which described a growing sense of social precarity and disillusionment with mainstream politics in Britain: https://www.theguardian.com/society/series/insecure-britain

the anxieties connected with the housing crisis – rise of property costs, cutbacks on welfare housing, increasing precarity of living conditions – may be among the most tangible in everyday life. It is not surprising, then, that the disruptive power of threats to home as a source of security and comfort has been at the centre of a series of recent British plays. While many of these are marked by documentary realism, incorporating real-life testimonies in order to evoke empathy with those hit hardest by the crisis, there is also a notable subset that veer to the other side of the sur/realist spectrum, reflecting on the crisis in highly stylized dystopian scenarios.
In this article, I propose the concept of ‘playhouse Gothic’ to describe Mike Bartlett’s Game and Philip Ridley’s Radiant Vermin (both 2015). Both are explorations of the affective and social implications of the housing crisis that fall into the latter category. The case studies examine how in both plays the interplay between dramatic and theatrical space foregrounds the extent to which our homes themselves are sources of insecurity. More specifically, the plays employ the mode of the Gothic in order to involve their audiences in an emotionally loaded spatial experience, thereby also inviting them to reflect on their own socio-economic anxieties and implication in perpetuating structures of inequality. The analyses take into account the dramatic texts and the set-up of concrete performances as well as reviews documenting viewers’ responses to the plays.
FeArt and Dance-xiety in Nature Theater of Oklahoma’s Pursuit of Happiness: Artificiality, Authenticity and Fun as the Building Stones of a Hopeful Performative
Authors: Lacko Ivan 
Published: May 2019

Abstract

Pursuit of Happinessis a 2017 co-production of the American group Nature Theater of Oklahoma and the Slovenia-based, multinational En-Knap dance company. The genre-defying production provocatively misleads the audience through the textual as well as performative aspects of the piece. From slapstick scenes, through dynamic dance movements, all the way to philosophically challenging perceptions about the nature of our reality, the play balances on the edge of timid expressions of existentialist angst, Baudrillardian overload of simulacra, and an attempt to address a mechanical reproduction of art (and life) reminiscent of Walter Benjamin.This contribution endeavours to present an analysis of Pursuit of Happiness as an explosive contemporary piece that portrays a disintegrating world, where fear and anxiety engulf people’s lives as suddenly as the play’s formal structure breaks and changes. Following Jill Dolan’s ruminations about “hopeful performatives”, the paper seeks to plot out a set of such performatives and narratives in the selected play, and to show how they function in the liminal combination of dance and drama, movement and performance, art and life, and how these narratives can become part of what Elliot Leffler and Michael Mellas call divergent dramaturgy.
The crystal structure of a matrine derivative, 13-(4-Cl-pyrrole)-matrine, C18H26ClN4O
Authors: Jing-Min Ye , Hui-Qing He , Xu-Hong Jiang , Zhan-Mei Liu , Xing-An Cheng , Zhao-Chang He 
Published: May 2019

Abstract
C18H26ClN4O, orthorhombic, P212121 (no. 19), a = 5.3476(1) Å, b = 14.4068(2) Å, c = 22.3285(4) Å, V = 1720.23(5) Å3, Z = 4, R
gt(F) = 0.0328, wR
ref(F
2) = 0.0774, T = 100 K.
Synthesis and crystal structure of (±)-Ethyl 5′-(difluoromethyl)-2-oxo-4′,5′-dihydrospiro[indoline-3,3′-pyrazole]-4′-carboxylate, C14H13F2N3O3
Authors: Li Wu-Wu , Zheng Min-Yan , Guo Ying , Jiang Yan-Ping , Wang Qiao , Wang Mei , Ji Min-Xiang , Zhang Yu-Tao , Zhang Zun-Ting 
Published: May 2019

Abstract
C14H13F2N3O3, triclinic, P1̄ (no. 2), a = 9.4486(7) Å, b = 12.4694(8) Å, c = 13.8690(8) Å, α = 65.734(6)°, β = 74.523(5)°, γ = 83.726(6)°, V = 1435.63(18) Å3, Z = 4, Rgt
(F) = 0.0495, wR
ref(F
2) = 0.1249, T = 293(2) K.