bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining a guided self-help and brief alcohol intervention to improve mental health and reduce substance use among refugee men in Uganda: a cluster-randomized feasibility trial
Authors: Greene M. Claire , Andersen Lena S. , Leku Marx R. , Au Teresa , Akellot Josephine , Upadhaya Nawaraj , Odokonyero Raymond , White Ross , Ventevogel Peter , Garcia-Moreno Claudia , Tol Wietse A. 
Published: November 2024

Abstract
Evidence on the effectiveness and implementation of mental health and psychosocial support (MHPSS) interventions for men in humanitarian settings is limited. Moreover, engagement and retention of men in such interventions has been challenging. Adaptations may therefore be required to improve the appropriateness and acceptability of these interventions for men. This study conducted formative research and examined the feasibility of combining an MHPSS intervention, Self-Help Plus, with a brief intervention to reduce harmful alcohol use among refugee men in Uganda. We conducted a cluster randomized feasibility trial comparing the combined alcohol intervention and Self-Help Plus, Self-Help Plus alone and enhanced usual care. Participants were 168 South Sudanese refugee men in Rhino Settlement who reported moderate or high levels of psychological distress. Session attendance was adequate: all sessions had at least 69% of participants present. Participant outcome measures, including symptoms of psychological distress, functional impairment, self-defined problems, depressive symptoms, post-traumatic stress symptoms, overall substance use risk, substance specific risk (alcohol, cannabis, stimulants and sedatives) and well-being, were sensitive to change. A combined approach to addressing mental health and alcohol use appears feasible among men in refugee settings, but further research is needed to examine the effectiveness of combined interventions among men.
The burden and distribution of cystic echinococcosis in Bhutan: a retrospective study
Authors: Tenzin Chador , Dendup Tashi , Torgerson P. R. , Deplazes Peter , Zangmo Sonam , Wangmo Chador , Tsheten Tsheten , Zangpo Tandin 
Published: November 2024

Abstract
Cystic echinococcosis (CE), caused by Echinococcus granulosus s.l. is a neglected zoonosis posing a significant public health challenge. Little is known about human CE in Bhutan. This study was conducted to gain an understanding of the burden, distribution, and potential risk factors of CE in Bhutan. From January 2015 to December 2019 data from Jigme Dorji Wangchuck National Referral Hospital (JDWNRH) and 6 other district-level hospitals were reviewed. Descriptive statistics were used to summarize the data. DALYs and Poisson regression models were used to estimate the burden and explore the relationship between cases and possible risk factors. A total of 159 cases were recorded. Most cases (145) were admitted to the surgical ward and 14 cases were referred to India. The average annual incidence was 4.4 cases per 100 000 population. The burden of disease was estimated to be approximately 39 DALYs per year for treatment-seeking cases, or possibly 80 DALYs per year including non-treatment seeking cases. This translates to approximately to 5.2 DALYs and 10.2 per 100 000 per year respectively. The commonest sites of infection were the liver (78%) and lungs (13%). Most cases were treated with surgery (>82%), and more than 47% were admitted to the hospital for >4 days. Policy interventions targeting community engagement, awareness, education, high risk occupational groups, females, and those living in the endemic districts of the central and western regions may yield larger gains. More studies and the institution of a surveillance system can help better guide policy interventions.
Argument ordering in simple sentences is affected by age of first language acquisition: Evidence from late first language signers of ASL
Authors: Miles Rachel , Hatrak Marla , İlkbaşaran Deniz , Mayberry Rachel 
Published: November 2024

Abstract
Research on the language acquisition of deaf individuals who are exposed to accessible linguistic input at a variety of ages has provided evidence for a sensitive period of first language acquisition. Recent studies have shown that deaf individuals who first learn language after early childhood, late first-language learners (LL1), do not comprehend reversible Subject-Verb-Object (SVO) sentences. The present study analyzed 478 signed productions elicited with pictures depicting simple events with one or two arguments by 28 signers. The argument order patterns of native signers converged with one another and the word order patterns of American Sign Language (ASL). By contrast, the ordering patterns of the LL1 signers did not converge with one another or with the patterns of the native signers. This indicates that early childhood is a period of heightened sensitivity to basic word order and may help explain why complex structures are difficult for LL1 signers to learn.
Compatibilism and Truly Minimal Morality
Authors: Quigley Travis 
Published: November 2024

AbstractI formulate a compatibilism that is distinctively responsive to skeptical worries about the justification of punishment and other moral responsibility practices. I begin with an evolutionary story explaining why backward-looking reactive attitudes are “given” in human society. Cooperative society plausibly could not be sustained without such practices. The necessary accountability practices have complex internal standards. These internal standards may fully ground the appropriateness of reactive attitudes. Following a recent analogy, we can similarly hold that there are no external standards for what is funny; the norms of comedy are complex, but funny is funny. However, this is compatible with moral reasons to change the practices themselves, and therefore change what is fitting within them: in the first instance, a moralistic “that's not funny” is ill-fitting, but “that shouldn't be funny” can be apt. The analogous reformist position prescribes practices constituting the minimal responsibility norms necessary for cooperative society.
Airborne lidar at Guiengola, Oaxaca: Mapping a Late Postclassic Zapotec city
Authors: Ramón Celis Pedro Guillermo 
Published: November 2024

AbstractThe site of Guiengola is an example of one of the settlements built by the Zapotecs during their fourteenth- to fifteenth-century migration to the Southern Isthmus of Tehuantepec. Although Guiengola is well known in the ethnohistorical record as being the place where the Mexica armies were defeated by Zapotec forces during the late fifteenth century, the full extension of the site was previously unknown. Despite evidence of a dense population at the site, it has been mistakenly characterized as a fortress for housing soldiers and troops from the nearby town of Tehuantepec. Here, I present the research of the Guiengola Archeological Project, which conducted a lidar scan and archaeological surveys between 2018 and 2023. In this article, I share a comprehensive map of Guiengola, a Postclassic Mesoamerican city. My analysis identifies a large settlement that covered 360 ha and included a walled system of fortifications, an internal road network, and a hierarchically organized city. The findings of this project expand our understanding of the variations and social divisions in the city's internal urban organization, which in turn, allow us to deepen our comprehension of the transition to the Early Colonial barrio organization of Tehuantepec.
Groupoidal realizability for intensional type theory
Authors: Speight Samuel L. 
Published: November 2024

AbstractWe develop realizability models of intensional type theory, based on groupoids, wherein realizers themselves carry non-trivial (non-discrete) homotopical structure. In the spirit of realizability, this is intended to formalize a homotopical BHK interpretation, whereby evidence for an identification is a path. Specifically, we study partitioned groupoidal assemblies. Categories of such are parameterized by “realizer categories” (instead of the usual partial combinatory algebras) that come equipped with an interval qua internal cogroupoid. The interval furnishes a notion of homotopy as well as a fundamental groupoid construction. Objects in a base groupoid are realized by points in the fundamental groupoid of some object from the realizer category; isomorphisms in the base groupoid are realized by paths in said fundamental groupoid. The main result is that, under mild conditions on the realizer category, the ensuing category of partitioned groupoidal assemblies models intensional (1-truncated) type theory without function extensionality. Moreover, when the underlying realizer category is “untyped,” there exists an impredicative universe of 1-types (the modest fibrations). This is a groupoidal analog of the traditional situation.
Expansion of the critical intensity for the random connection model
Authors: Dickson Matthew , Heydenreich Markus 
Published: November 2024

AbstractWe derive an asymptotic expansion for the critical percolation density of the random connection model as the dimension of the encapsulating space tends to infinity. We calculate rigorously the first expansion terms for the Gilbert disk model, the hyper-cubic model, the Gaussian connection kernel, and a coordinate-wise Cauchy kernel.
Adaptation and validation of the Turkish version of the Bolton Compassion Strengths Indicators scale among nursing students: A psychometric analysis
Authors: Ercan Feride , Kızılırmak Tatu Merve , Demir Satı 
Published: November 2024

AbstractObjectivesThe study used a methodological design to adapt a Turkish translation and validate the Bolton Compassion Strengths Indicators scale.MethodsThe sample of the study consisted of 500 nursing students. Partial least squares structural equation modelling was used to analyze the construct and internal validiy. The values of average variance explained were analyzed for convergent validity. Tukey’s test of additivity examined the additivity, and Hotelling’s T2 test examined the mean difference between items. Internal consistency and test–retest reliability were ensured for reliability. Test and retest scores were compared by applying the paired samples t-test and Wilcoxon test, and the fit was analyzed through the intra-class correlation coefficient.ResultsThe Turkish version of the scale consisted of 34 items and 8 subscales. The Cronbach’s alpha coefficient of the overall scale was 0.954. The scale was highly reliable and displayed psychometric solid properties.Significance of resultsIt has been determined that the Turkish version of the Bolton Compassion Strengths Indicators scale is a comprehensive, easy-to-understand measurement tool with a broad perspective that can be safely applied to future nurse candidate students. The scale has been evaluated as a reliable measurement tool that can provide cross-cultural measurement.
The public health significance of prior homelessness: findings on multimorbidity and mental health from a nationally representative survey
Authors: Chilman N. , Schofield P. , McManus S. , Ronaldson A. , Stagg A. , Das-Munshi J. 
Published: November 2024

Abstract

Aims
The associations of prior homelessness with current health are unknown. Using nationally representative data collected in private households in England, this study aimed to examine Common Mental Disorders (CMDs), physical health, alcohol/substance dependence, and multimorbidities in people who formerly experienced homelessness compared to people who never experienced homelessness.

Methods
This cross-sectional study utilised data from the 2007 and 2014 Adult Psychiatric Morbidity Surveys. Former homelessness and current physical health problems were self-reported. Current CMDs, alcohol dependence and substance dependence were ascertained using structured validated scales. Survey-weighted logistic regression was used to compare multimorbidities (conditions in combination) for participants who formerly experienced homelessness with those who had never experienced homelessness, adjusting for sociodemographic characteristics, smoking status and adverse experiences. Population attributable fractions (PAFs) were calculated.

Results
Of 13,859 people in the sample, 535 formerly experienced homelessness (3.6%, 95% CI 3.2–4.0). 44.8% of people who formerly experienced homelessness had CMDs (95% CI 40.2–49.5), compared to 15.0% (95% CI 14.3–15.7) for those who had never experienced homelessness. There were substantial associations between prior homelessness and physical multimorbidity (adjusted odds ratio [aOR] 1.98, 95% CI 1.53–2.57), CMD–physical multimorbidity (aOR 3.43, 95% CI 2.77–4.25), CMD–alcohol/substance multimorbidity (aOR 3.53, 95% CI 2.49–5.01) and trimorbidity (CMD–alcohol/substance–physical multimorbidity) (aOR 3.26, 95% CI 2.20–4.83), in models adjusting for sociodemographic characteristics and smoking. After further adjustment for adverse experiences, associations attenuated but persisted for physical multimorbidity (aOR 1.40, 95% CI 1.10–1.79) and CMD–physical multimorbidity (aOR 1.55, 95% CI 1.20–2.00). The largest PAFs were observed for CMD–alcohol/substance multimorbidity (17%) and trimorbidity (16%).

Conclusions
Even in people currently rehoused, marked inequities across multimorbidities remained evident, highlighting the need for longer-term integrated support for people who have previously experienced homelessness.
Exploring Comorbidity Between Anxiety and Depression in Spanish-Speaking School-Aged Children: A Network Analysis Approach
Authors: Fernández-Martínez Iván , Idrobo Gutiérrez Angélica , Orgilés Amorós Mireia 
Published: November 2024

AbstractAnxiety and depression are highly prevalent and comorbid problems in childhood, which deserve greater understanding for effective prevention and treatment. The main aim of the present study was to explore the comorbidity between anxiety and depression symptoms using a novel and valuable approach to study comorbidity, such as network analysis. Specifically, the connectivity between symptoms and possible relevant symptoms was examined through comorbidity estimation and shortest pathway networks, as well as bridge symptoms. This study comprised 281 Spanish-speaking children aged 8–12 years (45.2% girls), whose anxiety and depression symptoms were assessed through specific brief parent-report measures. Analyses revealed that in the comorbidity network, the most central symptoms were related to depression (“No good anymore,” “Could never be as good,” “Hated self,” “Did everything wrong,” “Nobody loved him/her”) or anxiety (“Suddenly feels really scared”). Furthermore, it was found that the most central bridge symptoms, whose activation would play a key role in the activation of other domain symptoms, were anxiety symptoms such as “Trouble going to school” and “Suddenly feels really scared” and depression symptoms, such as “Could never be as good” and “Hated self.” Additionally, the shortest path network suggested the existence of different possible pathways of connection between anxiety and depression symptoms. Overall, these findings help to understand the complexity of the anxiety-depression comorbidity. It suggests the existence of central and bridge symptoms that complement previous studies, which may be potential targets for interventions to prevent and treat childhood anxiety and depression.
Rapid Down‐Slope Transport of Fresh Dissolved Organic Matter to the Deep Ocean in the Eastern North Atlantic
Authors: Wei Bingbing , Seidel Michael , Mollenhauer Gesine , Lefebvre Alice , Miramontes Elda , Grotheer Hendrik , Elvert Marcus , Wendt Jenny , Dittmar Thorsten , Holtappels Moritz 
Published: November 2024

AbstractIntense convective mixing in the central North Atlantic is a major gateway for dissolved organic matter (DOM) into the deep ocean, sustaining elevated dissolved organic carbon (DOC) concentrations. Rapid down‐slope transport on adjacent Irish and Hebrides Margins represents another, less‐explored mechanism contributing to the deep‐sea DOM reservoir. Our analyses of solid‐phase extractable DOM (SPE‐DOM) in bottom waters in this region showed 7–11 μM higher DOC concentration and 190–330 years youngerSPE‐DOM radiocarbon ages compared to similar depths in the open eastern North Atlantic. We estimated a down‐slope DOC flux of 43 Tg C yr−1 from the Irish and Hebrides shelves. During transport, conservative mixing, dominated by physical rather than biological/chemical processes, determined the molecular DOM composition, while minor particulate organic matter degradation introduced less‐refractory DOM with terrigenous characteristics. Thus, rapid down‐slope transport emerges as an efficient conduit for delivering fresh DOM into the deep ocean.
The inflammasome-activating poxvirus peptide IAMP29 promotes antimicrobial and anticancer responses
Authors: Roh Taylor , Seo Wonhyoung , Won Minho , Yang Woo Seok , Sapkota Asmita , Park Eun-Jin , Yun Sung-Ho , Jeon Sang Min , Kim Kyung Tae , Lee Bomi , Ryu Gyoungah , Lee Sang-Hee , Shin Jung-Min , Shin Hyo Jung , Kim Young Jae , Lee Young , Chung Chaeuk , Song Ik-Chan , Song Hyun Kyu , Jo Eun-Kyeong 
Published: November 2024

AbstractPoxviruses are implicated in a variety of infectious diseases; however, little is known about the molecular mechanisms that underlie the immune response during poxvirus infection. We investigated the function and mechanisms of the monkeypox virus envelope protein (A30L) and its core peptide (IAMP29) during the activation of innate immune responses. The A30L protein and its core peptide, IAMP29 (a 29-amino-acid inflammasome-activating peptide encompassing His40 to Asp69 of A30L), strongly activated the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome by inducing the production of mitochondrial reactive oxygen species in human monocytes. Specifically, IAMP29 triggered metabolic reprogramming toward glycolysis and interacted with pyruvate kinase M isoforms (PKM1 and PKM2), thus activating the NLRP3 inflammasome and interleukin (IL)-1β production in human monocytes and murine macrophages. In human primary monocyte-derived macrophages, IAMP29-induced inflammasome activation promoted an antimicrobial response to rapidly growing non-tuberculous mycobacteria. Furthermore, IAMP29 exhibited cytotoxic activity against leukemia cells, which was mediated by pyroptosis and apoptosis. These findings provide insights into the immunological function of the poxvirus envelope peptide and suggest its therapeutic potential.
Sorcin can trigger pancreatic cancer-associated new-onset diabetes through the secretion of inflammatory cytokines such as serpin E1 and CCL5
Authors: Gong Jiali , Li Xiawei , Feng Zengyu , Lou Jianyao , Pu Kaiyue , Sun Yongji , Hu Sien , Zhou Yizhao , Song Tianyu , Shangguan Meihua , Zhang Kai , Lu Wenjie , Dong Xin , Wu Jian , Zhu Hong , He Qiaojun , Xu Hongxia , Wu Yulian 
Published: November 2024

AbstractA rise in blood glucose is an early warning sign of underlying pancreatic cancer (PC) and may be an indicator of genetic events in PC progression. However, there is still a lack of mechanistic research on pancreatic cancer-associated new-onset diabetes (PCAND). In the present study, we identified a gene SRI, which possesses a SNP with the potential to distinguish PCAND and Type 2 diabetes mellitus (T2DM), by machine learning on the basis of the UK Biobank database. In vitro and in vivo, sorcin overexpression induced pancreatic β-cell dysfunction. Sorcin can form a positive feedback loop with STAT3 to increase the transcription of serpin E1 and CCL5, which may directly induce β-cell dysfunction. In 88 biopsies, the expression of sorcin was elevated in PC tissues, especially in PCAND samples. Furthermore, plasma serpin E1 levels are higher in peripheral blood samples from PCAND patients than in those from T2DM patients. In conclusion, sorcin may be the key driver in PCAND, and further study on the sorcin-STAT3-serpin E1/CCL5 signaling axis may help us better understand the pathogenesis of PCAND and identify potential biomarkers.
Quantitative phase imaging endoscopy with a metalens
Authors: Shanker Aamod , Fröch Johannes E. , Mukherjee Saswata , Zhelyeznyakov Maksym , Brunton Steven L. , Seibel Eric J. , Majumdar Arka 
Published: November 2024

AbstractQuantitative phase imaging (QPI) recovers the exact wavefront of light from intensity measurements. Topographical and optical density maps of translucent microscopic bodies can be extracted from these quantified phase shifts. We demonstrate quantitative phase imaging at the tip of a coherent fiber bundle using chromatic aberrations inherent in a silicon nitride hyperboloid metalens. Our method leverages spectral multiplexing to recover phase from multiple defocus planes in a single capture using a color camera. Our 0.5 mm aperture metalens shows robust quantitative phase imaging capability with a $${28}^{\circ}$$

28

∘

field of view and 0.$${2}{\pi}$$

2
π

phase resolution ( ~ 0.$${1}{\lambda}$$

1
λ

in air) for experiments with an endoscopic fiber bundle. Since the spectral functionality is encoded directly in the imaging lens, the metalens acts both as a focusing element and a spectral filter. The use of a simple computational backend will enable real-time operation. Key limitations in the adoption of phase imaging methods for endoscopy such as multiple acquisition, interferometric alignment or mechanical scanning are completely mitigated in the reported metalens based QPI.
Piezoelectric MEMS microphones based on rib structures and single crystal PZT thin film
Authors: You Zhiwei , Gan Jinghan , Yang Chong , Tuerhong Renati , Zhao Lei , Lu Yipeng 
Published: November 2024

AbstractIn this study, a controllable mass‒frequency tuning method is presented using the etching of rib structures on a single-crystal PZT membrane. The rib structures were optimized to reduce the membrane mass while maintaining the stiffness; therefore, the center frequency could be increased to improve the low-frequency bandwidth of microphones. Additionally, this methodology could reduce the modulus and improve the sensitivity for the same resonant frequency, which typically indicates the maximum acoustic overload point (AOP). The PZT film was chosen because of its greater density; the simulation results showed that PZT could provide a greater frequency tuning (24.9%) compared to that of the AlN film (5.8%), and its large dielectric constant enabled the optimal design to have small electrodes at the maximum stress location while mitigating the sacrificial capacitance effect on electrical gain. An analytical model of rib-structure microphones was established and greatly reduced the computing time. The experimental results of the impedance tests revealed that the center frequencies of the six microphones shifted from 74.6 kHz to 106.3 kHz with rib-structure inner radii ranging from 0 μm to 340 μm; this result was in good agreement with the those of the analytical analysis and finite element modeling. While the center frequency greatly varied, the measured sensitivities at 1 kHz only varied within a small range from 22.3 mV/Pa to 25.7 mV/Pa; thus, the membrane stiffness minimally changed. Moreover, a single-crystal PZT film with a (100) crystal orientation and 0.24-degree full width at half maximum (FWHM) was used to enable differential sensing and a low possibility of undesirable polarization. Paired with a two-stage differential charge amplifier, a differential sensing microphone was experimentally demonstrated to improve the sensitivity from 25.7 mV/Pa to 36.1 mV/Pa and reduce the noise from −68.2 dBV to −82.8 dBV.