bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived enabling factors and barriers for the implementation of improvements in health care in order to achieve patient‐centred care: A case report from Sweden
Authors: Wijk Katarina , Åberg Jönsson Fredrik , Lindberg Maria 
Published: September 2019

AbstractRationale, aim, and objectivesMore knowledge is needed regarding the complex factors and perceptions that enable the implementation of change in health care. The study aimed to examine the enabling factors and barriers encountered in the implementation of improvements in health care in order to achieve patient‐centred care (PCC) and to study if there was a correlation in the extent the improvements were perceived to be implemented and the preconditions that were considered to affect them.MethodsUsing a mixed method design, data were gathered via a questionnaire and individual interviews with health care personnel, clinic managers, and first‐line managers. The data collection and analyses were based on the framework for Promoting Action on Research Implementation in Health Services (PARiHS). Correlations between PCC improvements and preconditions for improvements were performed.ResultsA high level of involvement, knowledge, and adequate resources were considered important to achieve an implementation of PCC with joint responsibility. Leadership and management need to be explicit and promote continuous follow‐up and feedback. Preconditions for improvement had a linear correlation with the perceived level of implementation. Knowledge‐related preconditions had greatest impact on implementation.ConclusionsThe PARiHS framework was appropriate to use since the three components of evidence, context, and facilitation present different important preconditions in the implementation process. Evidence was the highest rated contributor since evidence‐based practices in health care are necessary. It is vital that the important role of the context and facilitators is acknowledged in the implementation process to enable a successful implementation of change. There is a need to incorporate a clear strategy involving all levels in the organization. Furthermore, leaders play an important role in the implementation by facilitating communication and support and by having trust in facilitators and health care personnel. The results are applicable to other interventions implementing change in health care.
Developmental outcomes following prenatal exposure to methamphetamine: A Western Australian perspective
Authors: O'Connor Angela , Seeber Carly , Harris Emma , Hamilton Dale , Sachmann Mark , Fisher Colleen 
Published: September 2019

AimTo describe neurodevelopmental outcomes among a cohort of Western Australian infants exposed to maternal methamphetamine use during pregnancy and to determine whether the Ages and Stages Questionnaire is a reliable screening tool for this population.MethodsMethamphetamine‐using women were approached for participation when referred to the state‐wide perinatal specialist drug and alcohol service for pregnancy care. Drug use during pregnancy was self‐reported in each trimester using a standardised questionnaire. Ages and Stages Questionnaires were completed by infant care givers at 4 and 12 months, and development was formally assessed at 12 months using the Griffiths Mental Development Scales. Griffiths results for term‐born infants in our cohort were compared to a Western Australian historical cohort of 443 healthy 1–2‐year‐olds.ResultsA total of 112 methamphetamine‐using pregnant women participated in the study, who gave birth to 110 live‐born infants. Ages and Stages Questionnaires were completed for 89 (81%) and 78 (71%) of the infants at 4 and 12 months, respectively. The Ages and Stages assessment identified 30 infants (33.7%) as having a potential developmental delay at 4 months and 29 infants (38.7%) as having a potential developmental delay at 12 months. Griffiths assessments were performed on 64 (58%) of the infants, with a mean general quotient of 92.7. This was significantly lower in term‐born babies compared to the historical cohort (who had a median general quotient of 113.0). There was a weak correlation between 12‐month Ages and Stages scores and Griffiths general quotients (r = 0.322) and no correlation between 4‐month Ages and Stages Questionnaire scores and later Griffiths results.ConclusionsInfants born to women reporting methamphetamine use during pregnancy are at increased risk of developmental delay and may warrant enhanced developmental follow‐up. However, they are a challenging group to follow due to complex psychosocial factors. Ages and Stages Questionnaires at 4 and 12 months were not helpful in screening for infants who had a developmental delay at 12 months.
Haematopoietic stem cell transplantation for inborn errors of immunity: 25‐year experience from University of Malaya Medical Centre, Malaysia
Authors: Ariffin Hany , Ab Rahman Syaza , Jawin Vida , Foo Jen Chun , Amram Nur Faizana , Mahmood Nur Mahirah , Yap Tsiao Yi , Rajagopal Revathi , Lum Su Han , Chan Lee Lee , Lin Hai Peng 
Published: September 2019

AimInborn errors of immunity (IEI) comprise a heterogeneous group of disorders of the immune system, most of which are curable by haematopoietic stem cell transplantation (HSCT). We present a 25‐year audit of HSCT for IEI at a tertiary‐level academic hospital in Malaysia.MethodsReview of medical records of all cases of IEI who underwent HSCT between January 1993 and December 2018 at our centre. Diagnoses, complications, HSCT protocols and outcome data were studied.ResultsThere were 20 patients (19 boys) with a median age at diagnosis of 11 months (range: 2 months to 12 years). Eleven of 19 (58%) had malnutrition at presentation. Donor sources were variable: 13 (65%) matched sibling donor (MSD), 4 (20%) human leukocyte antigen‐haploidentical donor (HD) and 3 (15%) matched unrelated donor (MUD). Conditioning regimens were physician‐dependent and adapted to each patient's clinical status. Grades III–IV acute graft‐versus‐host disease occurred in two of three cases who received MUD grafts, 50% in those who received HD, and 8% in the MSD group. Transplant‐related mortality at day +100 was 5%. With a median follow‐up of 7.5 years, 18 (90%) patients are alive and free of infections.ConclusionOutcome of HSCT for IEI in our centre is comparable with international reports. HSCT results using HD and MUD grafts are also good despite challenges from acute graft‐versus‐host disease, providing a feasible alternative for patients without matched donors.
The Returns to Personality Traits Across the Wage Distribution
Authors: Collischon Matthias 
Published: September 2019

AbstractThis paper investigates variation in the wage effects of personality traits across the wage distribution. I expect increasing magnitudes of the effects of personality traits on wages for high‐ compared to low‐wage employees and test this hypothesis using unconditional quantile regressions with data from Germany, the UK, and Australia. The findings show increasing magnitudes of the effects of especially agreeableness, neuroticism and risk taking across the wage distribution and provide further evidence for the importance of non‐cognitive skills for wages.
Exploring researchers’ perspectives on authorship decision making
Authors: Maggio Lauren A , Artino Anthony R , Watling Christopher J , Driessen Erik W , O'Brien Bridget C 
Published: September 2019

ContextAuthorship has major implications for researchers’ careers. Hence, journals require researchers to meet formal authorship criteria. However, researchers frequently admit to violating these criteria, which suggests that authorship is a complex issue. This study aims to unpack the complexities inherent in researchers’ conceptualisations of questionable authorship practices and to identify factors that make researchers vulnerable to engaging in such practices.MethodsA total of 26 North American medical education researchers at a range of career stages were interviewed. Participants were asked to respond to two vignettes, of which one portrayed honorary authorship and the other described an author order scenario, and then to describe related authorship experiences. Data were analysed using thematic analysis.ResultsParticipants conceptualised questionable authorship practices in various ways and articulated several ethically grey areas. Personal and situational factors were identified, including hierarchy, resource dependence, institutional culture and gender; these contributed to participants’ vulnerability to and involvement in questionable authorship practices. Participants described negative instances of questionable authorship practices as well as situations in which these practices were used for virtuous purposes. Participants rationalised engagement in questionable authorship practices by suggesting that, although technically violating authorship criteria, such practices could be reasonable when they seemed to benefit science.ConclusionsAuthorship guidelines portray authorship decisions as being black and white, effectively sidestepping key dimensions that create ethical shades of grey. These findings show that researchers generally recognise these shades of grey and in some cases acknowledge having bent the rules themselves. Sometimes their flexibility is driven by benevolent aims aligned with their own values or prevailing norms such as inclusivity. At other times participation in these practices is framed not as a choice, but rather as a consequence of researchers’ vulnerability to individual or system factors beyond their control. Taken together, these findings provide insights to help researchers and institutions move beyond recognition of the challenges of authorship and contribute to the development of informed, evidence‐based solutions.
Phenotypic and seed structural comparison in hybrids of different Brassica rapa and B. oleracea
Authors: Rong Hao , Zhu Shuang , Xie Tao , Jiang Jinjin , Wang Youping 
Published: September 2019

AbstractBrassica napus is an important oil species with short history and narrow genetic background. Interspecific hybrids from crosses between B. oleracea and different B. rapa were obtained. We found the hybrids with white petal resembling B. oleracea, the flavonoid and phenolic content decreased in hybrids, agreeing with the expressional changes of flavonoid biosynthesis genes. Seed coat of hybrids resembled diploid parents, or partly resembled to each parent with a clear outline. The palisade layer in hybrids was thicker than parents, with similar pigment accumulation as B. oleracea but more than B. rapa. Differentially sized protein bodies (PBs) were found in hybrids. The radical and inner cotyledon of all hybrids were identified with larger but less PBs than parents. The average size of PBs in outer cotyledon of resynthesized B. napus was also larger than parents, but the number of PBs was not significantly reduced. The phenotypic and seed structural variations after polyploidization of B. napus would be interesting for genetic broadening and breeding of rapeseed.
Vice epistemology has a responsibility problem
Authors: Battaly Heather 
Published: September 2019

AbstractVice epistemology is in the business of defining epistemic vice. One of the proposed requirements of epistemic vices is that they are reprehensible—blameworthy in a non‐voluntarist way. Our problem, as vice epistemologists, is giving an analysis of non‐voluntarist responsibility that will count just the right qualities, no more and no less, as epistemic vices. If our analysis of non‐voluntarist responsibility ends up being too narrow, then it risks excluding some qualities that we want to count as epistemic vices, such as implicit biases. Whereas, if it ends up being too broad, it risks including qualities that we do not want to count as epistemic vices, such as impaired vision. I recommend a three‐step program for vice epistemologists: 1. admit that we have a responsibility problem; 2. strive to define the responsibility problem; 3. work together with specialists in non‐voluntarist responsibility to solve the responsibility problem.
Skepticism: Impractical, therefore implausible
Authors: Hannon Michael 
Published: September 2019

AbstractThe truth of skepticism would be depressing and impractical. Our beliefs would be groundless, we would know nothing (or almost nothing) about the world around us, and epistemic success would likely be impossible. But do these negative consequences have any bearing on the truth of skepticism? According to many scholars, they do not. The impractical consequences of skepticism are typically regarded as orthogonal to its truth. For this reason, pragmatic resolutions to skepticism are regularly dismissed. I will argue, however, that skepticism is implausible because it is impractical. In particular, skepticism is implausible because it goes against the point of epistemic evaluation.
Familial occurrence of mitral regurgitation in patients with mitral valve prolapse undergoing mitral valve surgery
Authors: Hiemstra Yasmine L , Wijngaarden Aniek L van , Bos Mathilde W , Schalij Martin J , Klautz Robert JM , Bax Jeroen J , Delgado Victoria , Barge-Schaapveld Daniela QCM , Marsan Nina Ajmone 
Published: September 2019

AbstractBackgroundInitial studies have suggested the familial clustering of mitral valve prolapse, but most of them were either community based among unselected individuals or applied non-specific diagnostic criteria. Therefore little is known about the familial distribution of mitral regurgitation in a referral-type population with a more severe mitral valve prolapse phenotype. The objective of this study was to evaluate the presence of familial mitral regurgitation in patients undergoing surgery for mitral valve prolapse, differentiating patients with Barlow's disease, Barlow forme fruste and fibro-elastic deficiency.MethodsA total of 385 patients (62 ± 12 years, 63% men) who underwent surgery for mitral valve prolapse were contacted to assess cardiac family history systematically. Only the documented presence of mitral regurgitation was considered to define ‘familial mitral regurgitation’. In the probands, the aetiology of mitral valve prolapse was defined by surgical observations.ResultsA total of 107 (28%) probands were classified as having Barlow's disease, 85 (22%) as Barlow forme fruste and 193 (50%) patients as fibro-elastic deficiency. In total, 51 patients (13%) reported a clear family history for mitral regurgitation; these patients were significantly younger, more often diagnosed with Barlow's disease and also reported more sudden death in their family as compared with ‘sporadic mitral regurgitation’. In particular, ‘familial mitral regurgitation’ was reported in 28 patients with Barlow's disease (26%), 15 patients (8%) with fibro-elastic deficiency and eight (9%) with Barlow forme fruste (P &lt; 0.001).ConclusionsIn a large cohort of patients operated for mitral valve prolapse, the self-reported prevalence of familial mitral regurgitation was 26% in patients with Barlow's disease and still 8% in patients with fibro-elastic deficiency, highlighting the importance of familial anamnesis and echocardiographic screening in all mitral valve prolapse patients.
“Mini” bank of only 8 donors supplies CMV-directed T cells to diverse recipients
Authors: Tzannou Ifigeneia , Watanabe Ayumi , Naik Swati , Daum Rachel , Kuvalekar Manik , Leung Kathryn S. , Martinez Caridad , Sasa Ghadir , Wu Mengfen , Gee Adrian P. , Krance Robert A. , Gottschalk Stephen , Heslop Helen E. , Omer Bilal 
Published: September 2019

Abstract
Cytomegalovirus (CMV) infections remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT), and standard antiviral therapies are associated with significant side effects and development of drug-resistant mutants. Adoptively transferred donor-derived CMV-specific T cells (CMVSTs) can provide an alternative treatment modality with few side effects but are not widely available due to their patient-specific nature. Here we report the establishment and use of a bank of CMVSTs derived from just 8 CMV-seropositive donors, with HLA types representing the diverse US population, as an “off-the-shelf” therapy to treat drug-refractory infections. To date, we have screened 29 patients for study participation and identified a suitable line, with ≥2 of 8 shared HLA antigens, for 28 (96.6%) patients with a median of 4 shared HLA antigens. Of these, 10 patients with persistent/refractory CMV infections or disease were eligible for treatment; a single infusion of cells produced 3 partial responses and 7 complete responses, for a cumulative response rate of 100% (95% confidence interval, 69.2-100) with no graft-versus-host disease, graft failure, or cytokine release syndrome. Potential wider use of the tested CMVSTs across transplant centers is made more feasible by our ability to produce sufficient material to generate cells for &gt;2000 infusions from a single donor collection. Our data indicate that a “mini” bank of CMVSTs prepared from just 8 well-chosen third-party donors can supply the majority of patients with an appropriately matched line that produces safe and effective anti-CMV activity post-HSCT.
Kinetics and mechanism of thermal degradation of vegetable-tanned leather fiber
Authors: Liu Jie , Luo Lan , Hu Yadi , Wang Fang , Zheng Xuejing , Tang Keyong 
Published: September 2019

Abstract
Thermal degradation of vegetable-tanned leather fiber (VLF) was investigated by thermogravimetric analysis aiming to know the exact kinetics and degradation mechanism. The thermogravimetric (TG) and differential thermogravimetric (DTG) curves showed that decomposition of the VLF occurs mainly in the range of 150–600 °C, and the latter exhibits asymmetrical peak with a pronounced shoulder. The decomposition process was first analyzed by deconvolution of the experimental DTG curves, followed by reconstruction of the weight loss profiles of two individual processes. Several common isoconversional approaches were applied to calculate the activation energy over a wide range of conversion for the sample, including modified Kissinger-Akahira-Sunose (MKAS), Friedman, and Flynn-Wall-Ozawa. The average activation energy of vegetable-tanned leather fiber was found to be 241.9 kJ mol− 1 by MKAS method. The activation energy values obtained for the pseudocomponents representing highly-crosslinked and low-crosslinked collagen in VLF were given as 190.6 and 124.8 kJ mol− 1, respectively. Generalized master plots results suggested that the reaction mechanism for highly-crosslinked collagen follows the random nucleation and growth process at conversion values lower than 0.5. When the conversion is higher than 0.5, the mechanism tends to random scission model. For low-crosslinked collagen, the degradation is mainly governed by random nucleation and nuclei growth. The gaseous products of VLF thermal degradation were analyzed with an online-coupled TG-Fourier transform infrared spectroscopy system.

Graphical abstract
A Randomized Community-based Exercise Training Trial in African American Men: Aerobic Plus Resistance Training and Insulin Sensitivity in African American Men
Authors: NEWTON ROBERT L. , JOHNSON WILLIAM D. , LARRIVEE SANDRA , HENDRICK CHELSEA , HARRIS MELISSA , JOHANNSEN NEIL M. , SWIFT DAMON L. , HSIA DANIEL S. , CHURCH TIMOTHY S. 
Published: September 2019

ABSTRACT

Purpose
To examine the impact of a community-based exercise training intervention on cardiometabolic outcomes in African American men who have a family history of type 2 diabetes.

Methods
The Aerobic Plus Resistance Training and Insulin Sensitivity in African American Men (ARTIIS) study randomized participants into either an exercise training intervention or an information only control group for 5 months. The exercise training intervention consisted of 150 min of moderate intensity aerobic activity and 2 d of resistance training per week, consistent with the current federal physical activity guidelines. Participants in the control group received monthly newsletters featuring topics focused heavily on type 2 diabetes education and prevention. Outcome data were analyzed using repeated-measures ANCOVA models and incorporating both intention-to-treat and per-protocol principles.

Results
Adherence to the aerobic and resistance training prescriptions were between 77% and 79%. Despite significant within group improvements in glucose and insulin levels (fasting, 2 h, 2 h minus baseline) and Homeostatic Model 2-Insulin Resistance, there were not significant between group differences. There was a marginally significant between group difference for Homeostatic Model 2-Beta (P < 0.06), and significant between group differences in peak cardiorespiratory fitness (P < 0.001) and waist circumference (P = 0.03).

Conclusions
These findings suggest that exercise training in accordance with the current national recommendations is effective in improving some health parameters in middle-age African American men who have a family history of type 2 diabetes, but did not have a significant impact on glycemic status.
Spo13 prevents premature cohesin cleavage during meiosis
Authors: Galander Stefan , Barton Rachael E. , Kelly David A. , Marston Adèle L. 
Published: September 2019

Background:Meiosis produces gametes through two successive nuclear divisions, meiosis I and meiosis II. In contrast to mitosis and meiosis II, where sister chromatids are segregated, during meiosis I, homologous chromosomes are segregated. This requires the monopolar attachment of sister kinetochores and the loss of cohesion from chromosome arms, but not centromeres, during meiosis I. The establishment of both sister kinetochore mono-orientation and cohesion protection rely on the budding yeast meiosis I-specific Spo13 protein, the functional homolog of fission yeast Moa1 and mouse MEIKIN.Methods:Here we investigate the effects of loss ofSPO13on cohesion during meiosis I using a live-cell imaging approach.Results:Unlike wild type, cells lackingSPO13fail to maintain the meiosis-specific cohesin subunit, Rec8, at centromeres and segregate sister chromatids to opposite poles during anaphase I. We show that the cohesin-destabilizing factor, Wpl1, is not primarily responsible for the loss of cohesion during meiosis I. Instead, premature loss of centromeric cohesin during anaphase I inspo13Δcells relies on separase-dependent cohesin cleavage. Further, cohesin loss inspo13Δanaphase I cells is blocked by forcibly tethering the regulatory subunit of protein phosphatase 2A, Rts1, to Rec8.Conclusions:Our findings indicate that separase-dependent cleavage of phosphorylated Rec8 causes premature cohesin loss inspo13Δcells.
Percursos para achar-se: os deslocamentos de Robert Smithson
Authors: Tietz Anelise 
Published: September 2019

Este artigo discute a prática artística de Robert Smithson, com ênfase nas obras que apresentam deslocamentos, sejam físicos, sejam de trânsito entre espaço institucional e não-institucional, relacionando-os com uma experiência romântica, principalmente com a figura do flâneur. Entendemos que o deslocamento em Smithson busca uma experiência de individualidade e, portanto, intitulamos de percursos para achar-se. Abstract This article discusses the artistic practice of Robert Smithson, with emphasis on the works that present displacements, whether physical or in transit between institutional and non-institutional space, relating them to a romantic experience, especially with the figure of the flâneur. We understand that Smithson's displacement seeks an experience of individuality, it is called "routes to find yourself". Palavras-chave: Robert Smithson; Deslocamento; Flâneur; Arte Contemporânea. Key-words: Robert Smithson; Displacement; Flâneur; Contemporary Art.