bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrogen‐related receptor participates in regulating glycolysis and influences embryonic development in silkworm Bombyx mori
Authors: Long W. , Wu J. , Shen G. , Zhang H. , Liu H. , Xu Y. , Gu J. , Jia L. , Lin Y. , Xia Q. 
Published: October 2019

AbstractEstrogen‐related receptors (ERRs) play indispensable roles in development, energy metabolism, and cancers and are metabolic switches in Drosophila. However, the mechanism underlying their metabolic role is unknown in insects. This study analysed the expression profiles of Bombyx mori ERR (BmERR), hexokinase (BmHK), pyruvate kinase (BmPK) and phosphofructokinase (BmPFK) during embryonic development. The expression of BmERR tended to be similar to that of the other genes. We observed a regulatory association between BmERR and glycolytic rate‐limiting enzymes by BmERR overexpression, RNA interference (RNAi), and ERR inhibitors in B. mori embryo cells. Subsequently, ERR cis‐regulation elements (ERREs) were predicted and identified in the BmPFK promoter. Transfection assays, electrophoretic mobility shift assays and chromatin immunoprecipitation showed that BmERR can bind to one of these elements to regulate the expression of BmPFK. ERREs were also predicted in the BmHK and BmPK promoters. In the eggs, the expression of glycolytic rate‐limiting enzyme genes was suppressed when the expression of BmERR was interference by double‐stranded BmERR, the glucose levels also was increased. Meanwhile, the development of silkworm embryos was delayed by about 1 day. These results indicate that BmERR can bind to the ERREs of glycolytic gene promoters and regulate the expression of glycolytic genes, ultimately affecting embryonic development in silkworms.
Nursing home care for people with dementia: Update of the design of the Living Arrangements for people with Dementia (LAD)‐study
Authors: Prins Marleen , Willemse Bernadette M. , Heijkants Ceciel H. , Pot Anne Margriet 
Published: October 2019

AbstractAimThe aim of the current study is to describe the extended design of the Living Arrangements for people with Dementia (LAD)‐study.BackgroundThe demand for long‐term care in care homes increases with the growing number of people with dementia. However, quality of care in care homes needs improvement. It is important to monitor quality of care in care homes for the purposes of conducting scientific research, providing input for policy, and promoting practice improvement.DesignThe Living Arrangements for people with Dementia ‐study monitors changes in ‐ quality of ‐ care in care homes since 2008. With its extended design, the Living Arrangements for people with Dementia ‐study now also focuses on additional topics that are considered to improve quality of care: implementation of person‐centred care, involvement of family carers and volunteers and reducing psychotropic drugs and physical restraints using a multidisciplinary approach.MethodsThe data collection of the Living Arrangements for people with Dementia ‐study entails an interview with the manager and questionnaires are completed by care staff, family carers, volunteers, and multidisciplinary team members. This study is partly funded by the Dutch Ministry of Health, Welfare and Sports, grant number 323,088 and partly funded by the participating care homes.DiscussionResults of the Living Arrangements for people with Dementia ‐study will shed more light on variables related to quality of care in care homes for people with dementia.ImpactBased on the obtained information, appropriate efforts to improve quality of care can be discussed and implemented. Furthermore, the results of this study guide policy making, because it expands knowledge about the effects of changing policies and exposes topics that need further attention.Trial registration: Not applicable. This article does not report the results of a healthcare intervention on human participants.
Flying by the seat of their pants: A grounded theory of school nurse case management
Authors: Klein Nicole J. , Evans‐Agnew Robin 
Published: October 2019

AbstractAimsTo develop a theory describing the processes and actions involved with school nurse case management for school‐aged children with chronic conditions in the K12 system.DesignCase management is an essential practice for the school nurse. Little is known about actual case management practice in real‐world settings. Grounded theory methodology following a literature‐based conceptual model of school nurse case management.MethodsA purposive maximum variation sampling was used for data collection and analysis. Semi‐structured interviews conducted in‐person and via conferencing software from January to March 2017 with school nurses practicing in Washington State until data saturation was achieved. A condition lasting at least 6 months was also used to define a chronic condition.ResultsIn all, 14 school nurses with an average of 12 years of experience were interviewed. Analysis revealed that the core strategy used by participating nurses for case management involved navigating through ambiguity; balancing multiple roles; seeking guidance and training; acknowledging imperfect functioning and navigating poor system supports.ConclusionThe findings suggest that actual school nurse case management practice differs from best practice recommendations. Participants did not discuss health promotion or environmental management and did not act to set goals or prioritize care as suggested in the literature.ImpactThis article informs nursing leadership of the real‐world challenges faced by nurses performing case management in the school setting. These findings indicate that improvements in system supports and training, together with tolerance for the challenges nurses face in providing such care, might improve case management practice in the schools.
Experiences of participating in intergenerational interventions in older people's care settings: A systematic review and meta‐synthesis of qualitative literature
Authors: Bagnasco Annamaria , Hayter Mark , Rossi Silvia , Zanini Milko P. , Pellegrini Ramona , Aleo Giuseppe , Catania Gianluca , Sasso Loredana 
Published: October 2019

AbstractAimsTo synthesize the findings of qualitative research exploring the experiences of being involved in intergenerational interventions in older people's care settings.DesignA meta‐synthesis of the qualitative literature, employing Sandelowski and Barroso's method, was conducted.Data SourcesEight databases were searched in March 2017.Review MethodsThe PRISMA statement was used for reporting the different phases of the literature search and the Critical Appraisal Skills Programme (CASP) qualitative research checklist was used as an appraisal framework. Data synthesis was conducted using Sandelowski and Barroso's method.ResultsFour qualitative studies were included in the meta‐synthesis. Thematic analysis revealed four themes: ‘Recreating the family’; ‘Building intergenerational empathy and respect’; ‘Uplifting and energizing’; and ‘Engagement risks and challenges’.ConclusionThe meta‐synthesis strengthens the evidence that intergenerational interventions can be positive. However, it also shows that there may also be some negative aspects if not planned or managed carefully.ImpactThis review contributes to the body of evidence by synthesizing the experiences of older people and children involved in intergenerational interventions. Although qualitative literature supports the quantitative evidence that intergenerational interventions can have a positive effect, intergenerational interventions could also have negative effects on some participants. Older people may feel tired, or experience feelings of infantilization. Practitioners need to be more aware of the potential negative effects of intergenerational interventions and include risk assessment, possibly by requiring ethical scrutiny.
Mixed studies review of factors influencing receipt of pain treatment by injured black patients
Authors: Aronowitz Shoshana V. , Mcdonald Catherine C. , Stevens Robin C. , Richmond Therese S. 
Published: October 2019

AbstractAimTo explore the factors that influence provider pain treatment decision‐making and the receipt of pain management by injured Black patients in the United States.DesignWe completed a systematic mixed studies review using a results‐based convergent synthesis design.Data SourcesPubMed, SCOPUS and CINAHL were searched for articles published between 2007–2017 using the search terms ‘African American’, ‘Black American’, ‘race’, ‘pain treatment’, ‘pain management’ and ‘analgesia’. Twenty studies were included in this review.Review MethodA search of databases and hand‐searching identified peer‐reviewed published papers. The Mixed Method Appraisal Tool was used to appraise the studies.ResultsThe results indicate that healthcare provider characteristics, racial myths about pain sensitization and assumed criminality all impact provider treatment decision‐making and the receipt of pain treatment by injured Black patients.ImpactThis review addresses racial disparities in pain management by focusing on the factors that impact the receipt of pain treatment by injured Black patients. The findings will have an impact on providers who prescribe pain treatment and on the patients they treat. These findings suggest that assumed criminality of certain patients can negatively impact care, which is a type of bias not frequently explored or discussed in health disparities research. This review will help inform further research in healthcare disparities and prompt providers to examine their assumptions about the patients for whom they care.ConclusionThese results provide important areas for further study, including how assumed criminality of certain patients can have a negative impact on care.
Fire refugia facilitate forest and savanna co‐existence as alternative stable states
Authors: Beckett Heath , Bond William J. 
Published: October 2019

AbstractAimDoes complex topography facilitate the establishment and persistence of fire‐sensitive (forest) vegetation in a fire‐prone landscape? We test the prediction that fire‐sensitive vegetation will establish and persist in areas where the fire return interval is lower due to a topographic hindrance on fire spread.LocationHluhluwe–iMfolozi Park, KwaZulu Natal, South Africa.TaxonTerrestrial Plants.MethodsUsing aerial photographs from six time periods between 1937 and 2013, we mapped vegetation changes in Hluhluwe–iMfolozi Park (HiP). Using a generalized additive model (GAM), we built a habitat suitability index (HSI) map for forest vegetation based on topographic variables related to fire behaviour and the vegetation distribution maps from each time period. We investigated transitions between vegetation types between time periods based on the HSI map, as well as the effects of neighbourhood vegetation on transition probabilities.ResultsForest cover has increased overall from 1937 to 2013, however, this has not been a linear increase with a peak in extent in the early 1990s. The HSI, using topographic predictors associated with fire behaviour, correlates with areas of expansion and contraction of forest vegetation. The patterns of expansion and contraction are, however, more nuanced, with the in situ vegetation neighbourhood playing a large role.Main ConclusionsForest distributions in HiP have not remained static over time and have expanded into areas that were once savannas. This is a dynamic system where both forest and savanna boundaries can change considerably. Fire refugia are important for the long‐term persistence of forests in fire‐prone landscapes.
A strong east–west Mediterranean divergence supports a new phylogeographic history of the carob tree (Ceratonia siliqua, Leguminosae) and multiple domestications from native populations
Authors: Viruel Juan , Le Galliot Nicolas , Pironon Samuel , Nieto Feliner Gonzalo , Suc Jean‐Pierre , Lakhal‐Mirleau Fatma , Juin Marianick , Selva Marjorie , Bou Dagher Kharrat Magda , Ouahmane Lahcen , La Malfa Stefano , Diadema Katia , Sanguin Hervé , Médail Frédéric , Baumel Alex 
Published: October 2019

AbstractAimPhylogeography of fruit trees is challenging due to recurrent exchanges between domesticated and wild populations. Here we tested the eastern refugium hypothesis (ERH) for the carob tree, Ceratonia siliqua, which supports its natural and domestication origins in the eastern Mediterranean and a feral origin in the west.LocationMediterranean basin.TaxonCeratonia siliqua L., Leguminosae.MethodsA phylogenetic reconstruction based on two nuclear and one plastid sequences was performed to estimate the divergence time between the carob tree and its sister species, Ceratonia oreothauma. Variation from four plastid regions and 17 nuclear microsatellite loci were used to decipher genetic structure in the carob tree and to test coalescent‐based models by an Approximate Bayesian computation (ABC) approach. We assessed our hypotheses by examining palaeobotanical records and hindcasting the past distribution of the carob tree at Mid‐Holocene, Last Glacial Maximum (LGM) and Last Interglacial (LIG) using species distribution modelling.ResultsThe split between C. oreothauma and C. siliqua was estimated at 6.4 Ma, and a first divergence within C. siliqua at 1.3 Ma. After a continuous presence since the Oligocene, Ceratonia was rarely found in the fossil record during the Pleistocene but present in the western and the eastern Mediterranean. Plastid and nuclear markers, characterized by low allelic richness, revealed a strong west‐east genetic structuring. ABC analyses rejected the ERH.Main conclusionsOur study supports a severe population decline during LIG. The strong west–east divergence and the occurrence of four lineages within C. siliqua provided support for a new hypothesis of multiple domestications of the carob tree from native populations throughout the Mediterranean basin.
LNRLMI: Linear neighbour representation for predicting lncRNA‐miRNA interactions
Authors: Wong Leon , Huang Yu‐An , You Zhu‐Hong , Chen Zhan‐Heng , Cao Mei‐Yuan 
Published: October 2019

AbstractLncRNA and miRNA are key molecules in mechanism of competing endogenous RNAs(ceRNA), and their interactions have been discovered with important roles in gene regulation. As supplementary to the identification of lncRNA‐miRNA interactions from CLIP‐seq experiments, in silico prediction can select the most potential candidates for experimental validation. Although developing computational tool for predicting lncRNA‐miRNA interaction is of great importance for deciphering the ceRNA mechanism, little effort has been made towards this direction. In this paper, we propose an approach based on linear neighbour representation to predict lncRNA‐miRNA interactions (LNRLMI). Specifically, we first constructed a bipartite network by combining the known interaction network and similarities based on expression profiles of lncRNAs and miRNAs. Based on such a data integration, linear neighbour representation method was introduced to construct a prediction model. To evaluate the prediction performance of the proposed model, k‐fold cross validations were implemented. As a result, LNRLMI yielded the average AUCs of 0.8475 ± 0.0032, 0.8960 ± 0.0015 and 0.9069 ± 0.0014 on 2‐fold, 5‐fold and 10‐fold cross validation, respectively. A series of comparison experiments with other methods were also conducted, and the results showed that our method was feasible and effective to predict lncRNA‐miRNA interactions via a combination of different types of useful side information. It is anticipated that LNRLMI could be a useful tool for predicting non‐coding RNA regulation network that lncRNA and miRNA are involved in.
Matrix metalloproteases and TIMPs as prognostic biomarkers in breast cancer patients treated with radiotherapy: A pilot study
Authors: Olivares‐Urbano María Auxiliadora , Griñán‐Lisón Carmen , Zurita Mercedes , del Moral Rosario , Ríos‐Arrabal Sandra , Artacho‐Cordón Francisco , Arrebola Juan Pedro , González Amanda Rocío , León Josefa , Antonio Marchal Juan , Núñez María Isabel 
Published: October 2019

AbstractBreast cancer (BC) is the most common tumour in women and one of the most important causes of cancer death worldwide. Radiation therapy (RT) is widely used for BC treatment. Some proteins have been identified as prognostic factors for BC (Ki67, p53, E‐cadherin, HER2). In the last years, it has been shown that variations in the expression of MMPs and TIMPs may contribute to the development of BC. The aim of this pilot work was to study the effects of RT on different MMPs (‐1, ‐2, ‐3, ‐7, ‐8, ‐9, ‐10, ‐12 and ‐13) and TIMPs (‐1 to ‐4), as well as their relationship with other variables related to patient characteristics and tumour biology. A group of 20 BC patients treated with RT were recruited. MMP and TIMP serum levels were analysed by immunoassay before, during and after RT. Our pilot study showed a slight increase in the levels of most MMP and TIMP with RT. However, RT produced a significantly decrease in TIMP‐1 and TIMP‐3 levels. Significant correlations were found between MMP‐3 and TIMP‐4 levels, and some of the variables studied related to patient characteristics and tumour biology. Moreover, MMP‐9 and TIMP‐3 levels could be predictive of RT toxicity. For this reason, MMP‐3, MMP‐9, TIMP‐3 and TIMP‐4 could be used as potential prognostic and predictive biomarkers for BC patients treated with RT.
Effects of non‐surgical periodontal therapy on inflammatory markers of psoriasis: A randomized controlled trial
Authors: Ucan Yarkac Fatma , Ogrum Atiye , Gokturk Ozge 
Published: October 2019

AbstractAimThe purpose of this randomized controlled clinical study was to evaluate the effect of non‐surgical mechanical periodontal therapy on the inflammatory status and severity of psoriasis in subjects with psoriasis.Material and methodsThe study population consisted of 92 periodontitis patients with psoriasis vulgaris suffering from an untreated periodontal disease. Two randomized groups were formed from these patients: immediate periodontal therapy (test group,n = 46) and delayed periodontal therapy (control group,n = 46). Periodontal clinical measures, on salivary interleukin 2, interleukin 6 and secretory immunoglobulin A levels and the Psoriasis Area and Severity Index (PASI) scores were evaluated at baseline and on the 8th week in control and test groups.ResultsEight weeks after completion of non‐surgical periodontal therapy (test group) or initial examination (control group), a significant decrease was observed in interleukin 2, interleukin 6 level and in PASI score, whereas a significant increase was observed in secretory immunoglobulin A levels in the test group (p < .05).ConclusionWithin the limits of this study, the results suggest that effective periodontal therapy improves the psoriasis condition in patients afflicted by both diseases.
Neuroimmune interactions in chronic itch of atopic dermatitis
Authors: Yosipovitch G. , Berger T. , Fassett M.S. 
Published: October 2019

AbstractItch is a defining symptom of atopic dermatitis. Crosstalk between keratinocytes, the immune system and non‐histaminergic sensory nerves is responsible for the pathophysiology of chronic itch in atopic dermatitis. An expanding understanding of the contribution of the nervous system and its interaction with immune pathways in atopic itch are helping to identify new therapeutic strategies.
Real‐world comparative effectiveness of adalimumab, etanercept and methotrexate: a Swedish register analysis
Authors: Svedbom A. , Ståhle M. 
Published: October 2019

AbstractBackgroundThe advent of biosimilars may render etanercept (ETN) and adalimumab (ADA) viable alternatives to methotrexate (MTX) as first‐line systemics in psoriasis. However, real‐world relative effectiveness data comparing ADA and ETN to MTX are limited.ObjectiveTo estimate the relative effectiveness of ADA and ETN compared to MTX.MethodsWe analysed data from DermaReg, a regional register in Stockholm, Sweden, to estimate drug survival and mean Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) during maintenance treatment.ResultsA total of 524 patients initiated 727 treatment episodes with ADA, ETN or MTX. After adjusting for confounders, patients treated with ADA had better drug survival (HR: 0.67; P = 0.003), lower mean PASI (−2.0; P < 0.001) and lower mean DLQI (−0.9; P < 0.001) during maintenance treatment compared to patients treated with MTX. The results for ETN compared to MTX were mixed. After adjusting for confounding, there was no significant difference in drug survival (HR 1.23; P = 0.082), but patients on ETN had lower mean PASI (−0.7; P = 0.006) during maintenance treatment.ConclusionAdalimumab is superior to MTX in clinical practice whereas the relative effectiveness between ETN and MTX is less clear. This study also highlights the importance of appropriate confounding control in effectiveness analysis.
Crocodylomorph cranial shape evolution and its relationship with body size and ecology
Authors: Godoy Pedro L. 
Published: October 2019

AbstractCrocodylomorpha, which includes living crocodylians and their extinct relatives, has a rich fossil record, extending back for more than 200 million years. Unlike modern semi‐aquatic crocodylians, extinct crocodylomorphs exhibited more varied lifestyles, ranging from marine to fully terrestrial forms. This ecological diversity was mirrored by a remarkable morphological disparity, particularly in terms of cranial morphology, which seems to be closely associated with ecological roles in the group. Here, I use geometric morphometrics to comprehensively investigate cranial shape variation and disparity in Crocodylomorpha. I quantitatively assess the relationship between cranial shape and ecology (i.e. terrestrial, aquatic, and semi‐aquatic lifestyles), as well as possible allometric shape changes. I also characterize patterns of cranial shape evolution and identify regime shifts. I found a strong link between shape and size, and a significant influence of ecology on the observed shape variation. Terrestrial taxa, particularly notosuchians, have significantly higher disparity, and shifts to more longirostrine regimes are associated with large‐bodied aquatic or semi‐aquatic species. This demonstrates an intricate relationship between cranial shape, body size and lifestyle in crocodylomorph evolutionary history. Additionally, disparity‐through‐time analyses were highly sensitive to different phylogenetic hypotheses, suggesting the description of overall patterns among distinct trees. For crocodylomorphs, most results agree in an early peak during the Early Jurassic and another in the middle of the Cretaceous, followed by nearly continuous decline until today. Since only crown‐group members survived through the Cenozoic, this decrease in disparity was likely the result of habitat loss, which narrowed down the range of crocodylomorph lifestyles.