bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geometric morphometrics of nested symmetries unravels hierarchical inter- and intra-individual variation in biological shapes
Authors: Savriama Yoland , Gerber Sylvain 
Published: December 2018

AbstractSymmetry is a pervasive feature of organismal shape and the focus of a large body of research in Biology. Here, we consider complex patterns of symmetry where a phenotype exhibits a hierarchically structured combination of symmetries. We extend the Procrustes ANOVA for the analysis of nested symmetries and the decomposition of the overall morphological variation into components of symmetry (among-individual variation) and asymmetry (directional and fluctuating asymmetry). We illustrate its use with the Aristotle’s lantern, the masticatory apparatus of ‘regular’ sea urchins, a complex organ displaying bilateral symmetry nested within five-fold rotational symmetry. Our results highlight the importance of characterising the full symmetry of a structure with nested symmetries. Higher order rotational symmetry appears strongly constrained and developmentally stable compared to lower level bilateral symmetry. This contrast between higher and lower levels of asymmetry is discussed in relation to the spatial pattern of the lantern morphogenesis. This extended framework is applicable to any biological object exhibiting nested symmetries, regardless of their type (e.g., bilateral, rotational, translational). Such cases are extremely widespread in animals and plants, from arthropod segmentation to angiosperm inflorescence and corolla shape. The method therefore widens the research scope on developmental instability, canalization, developmental modularity and morphological integration.
Congo Red and amyloids: history and relationship
Authors: Yakupova Elmira I. , Bobyleva Liya G. , Vikhlyantsev Ivan M. , Bobylev Alexander G. 
Published: December 2018

AbstractStaining with Congo Red (CR) is a qualitative method used for the identification of amyloids in vitro and in tissue sections. However, the drawbacks and artefacts obtained when using this dye can be found both in vitro and in vivo. Analysis of scientific data from previous studies shows that CR staining alone is not sufficient for confirmation of the amyloid nature of protein aggregates in vitro or for diagnosis of amyloidosis in tissue sections. In the present paper, we describe the characteristics and limitations of other methods used for amyloid studies. Our historical review on the use of CR staining for amyloid studies may provide insight into the pitfalls and caveats related to this technique for researchers considering using this dye.
Ascorbic acid improves parthenogenetic embryo development through TET proteins in mice
Authors: Gao Wei , Yu Xianfeng , Hao Jindong , Wang Ling , Qi Minghui , Han Liang , Lin Chao , Wang Dongxu 
Published: December 2018

Abstract
The TET (Ten-Eleven Translocation) proteins catalyze the oxidation of 5mC (5-methylcytosine) to 5hmC (5-hydroxymethylcytosine) and play crucial roles in embryonic development. Ascorbic acid (Vc, Vitamin C) stimulates the expression of TET proteins, whereas DMOG (dimethyloxallyl glycine) inhibits TET expression. To investigate the role of TET1, TET2, and TET3 in PA (parthenogenetic) embryonic development, Vc and DMOG treatments were administered during early embryonic development. The results showed that Vc treatment increased the blastocyst rate (20.73 ± 0.46 compared with 26.57 ± 0.53%). By contrast, DMOG reduced the blastocyst rate (20.73 ± 0.46 compared with 11.18 ± 0.13%) in PA embryos. qRT-PCR (quantitative real-time PCR) and IF (immunofluorescence) staining results revealed that TET1, TET2, and TET3 expressions were significantly lower in PA embryos compared with normal fertilized (Con) embryos. Our results revealed that Vc stimulated the expression of TET proteins in PA embryos. However, treatment with DMOG significantly inhibited the expression of TET proteins. In addition, 5hmC was increased following treatment with Vc and suppressed by DMOG in PA embryos. Taken together, these results indicate that the expression of TET proteins plays crucial roles mediated by 5hmC in PA embryonic development.
Arc extinction of DC side low‐voltage breaker of charging device for battery pack in power plant based on insulated‐gate bipolar transistor module series technology
Authors: Yao Fang , Zhao Wangwang , Wang Jie , Li Zhigang 
Published: December 2018

The 110 V lead‐acid battery pack is widely used as the DC power supply for the load control of power plants. If the low‐voltage DC circuit breaker (LVDCCB) at the DC side of its charging device cannot operate in time when the fault current is flowing in charging loop, there will be of harmfulness to the safety and the durability of the battery pack. The plasma theory is applied to analyse the arc mechanism based on the voltage, the current and the power waveform of LVDCCB when it breaking. Then, an arc extinction is developed by assembling an additional device to LVDCCB. The device, connected to the contacts of LVDCCB, includes an insulated‐gate bipolar transistor series branch, an energy‐absorbing branch, a transfer switches branch, and a drive circuit. The test shows that the break time of LVDCCB, assembled with the additional device, is significantly shortened than that of the original.
Gesundheitszustand, Inanspruchnahme von Gesundheitsleistungen und Einstellung zur Rückkehr ins Erwerbsleben bei zeitlich befristeten Erwerbsminderungsrentnern
Authors: Briest Juliane 
Published: December 2018

ZusammenfassungZiel der Studie Ziel der Studie war eine träger- und diagnosenübergreifende, repräsentative Erhebung zu soziodemografischen Aspekten, Gesundheitszustand, Inanspruchnahme von Gesundheitsleistungen und Einstellung zur Rückkehr ins Erwerbsleben (RTW) bei aufgrund einer Erwerbsminderung (EM) berenteten Versicherten.Methodik 15.110 erstmalig und unabhängig vom Arbeitsmarkt befristete EM-Rentner im Alter von 30 bis 60 Jahre wurden zum Ende ihres ersten Bewilligungszeitraums schriftlich befragt. Diese Daten wurden durch Routinedaten der Rentenversicherungen ergänzt. Deskriptive Auswertungen erfolgten getrennt für die 4 häufigsten Berentungsdiagnosen (Psychische Störungen, Neubildungen, muskuloskelettale Erkrankungen, Krankheiten des Kreislaufsystems). Mögliche Gruppenunterschiede wurden mittels einfaktorieller Varianzanalyse bzw. Chi-Quadrat-Test geprüft.Ergebnisse 3 380 Befragte wurden in die Analysen eingeschlossen. Auch am Ende ihres ersten Bewilligungszeitraums zeigten sich diese Versicherten gesundheitlich stark eingeschränkt. Während des Rentenbezugs erhielten 36,8% der Rentner mit einer psychischen Störung eine medizinische Rehaleistung, Leistungen zur Teilhabe am Arbeitsleben wurden am ehesten Versicherten mit einer muskuloskelettalen Erkrankung gewährt (8,1%). Knapp ein Drittel der Befragten äußerte den Wunsch für ein RTW, die eigene Arbeitsfähigkeit sowie die Möglichkeit einen Arbeitsplatz zu finden, wurden jedoch eher pessimistisch gewertet. EM-Rentner mit Neubildungen zeigten hinsichtlich verschiedener gesundheitsrelevanter Aspekte sowie der Bewertung des RTW günstigere Werte als die Vergleichsgruppen.Schlussfolgerung Die Ergebnisse verdeutlichen, dass das mit der Befristung der EM-Rente verknüpfte Ziel der Wiederherstellung der Erwerbsfähigkeit nur unzureichend realisiert wird. Aufgrund der vielschichtigen und individuellen Problematiken bedarf es der Ausgestaltung neuer Angebote unter Einbeziehung der verschiedenen Akteure der Sozial- und Gesundheitssysteme.
Sharing of ADHD Information between Parents and Teachers Using an EHR-Linked Application
Authors: Michel Jeremy , Mayne Stephanie , Grundmeier Robert , Guevara James , Blum Nathan , Power Thomas , Coffin Emily , Miller Jeffrey , Fiks Alexander 
Published: December 2018

Background Appropriate management of attention-deficit/hyperactivity disorder (ADHD) involves parents, clinicians, and teachers. Fragmentation of interventions between different settings can lead to suboptimal care and outcomes. Electronic systems can bridge gaps across settings. Our institution developed an email-based software to collect ADHD information from parents and teachers, which delivered data directly to the clinician within the electronic health record (EHR).
Objective We sought to adapt our institution's existing EHR-linked system for ADHD symptom monitoring to support communication between parents and teachers and then to assess child characteristics associated with sharing of ADHD information.
Methods We updated our software to support automated sharing of ADHD information between parents and teachers. Sharing was optional for parents but obligatory for teachers. We conducted a retrospective cohort study involving 590 patients at 31 primary care sites to evaluate a system for sharing of ADHD-specific health information between parents and teachers. We used multivariable logistic regression to estimate associations between child characteristics and parental sharing. We further investigated the association between child characteristics and viewing of survey results delivered through the electronic communication system.
Results Most parents (64%) elected to share survey results with teachers at the first opportunity and the vast majority (80%) elected to share all possible information. Parents who elected to share usually continue sharing at subsequent opportunities (89%). Younger child age and performance impairments were associated with increased likelihood of sharing. However, parents viewed only 16% of teacher submitted surveys and teachers only viewed 30% of surveys shared by parents.
Conclusion This study demonstrates that electronic systems to capture ADHD information from parents and teachers can be adapted to support communication between them, and that parents are amenable to sharing ADHD information with teachers. However, strategies are needed to encourage viewing of shared information.
The Effect of BMI and Gender on Bleeding Events when Rivaroxaban Is Administered for Thromboprophylaxis Following Total Hip and Total Knee Arthroplasty
Authors: Krauss Eugene , Dengler Nancy , Simonson Barry , Altner Kathleen , Daly Madison , Segal Ayal , Cronin MaryAnne 
Published: December 2018

AbstractRivaroxaban is approved in Europe and the United States for thromboprophylaxis following total joint arthroplasty. As the rate of obesity increases, confirming safety and efficacy in this patient population is paramount. This retrospective chart review assessed the efficacy and safety of rivaroxaban between two body mass index (BMI) groups: normal or overweight (< 30 kg/m2) and obese or morbidly obese (≥30 kg/m2). Safety outcome was a major bleeding event, defined as a decrease in hemoglobin of at least 2 g/dL from postoperative day 1(POD 1) to discharge or a blood transfusion of at least two units. Efficacy outcome was venous thromboembolism within 35 days postoperatively. There were 68 (68/1,241; 5.48%) major bleeding events. There was no significant association between major bleeding events and BMI in the univariable analysis (p < 0.36). However, after adjusting for other factors in the multivariable model, there was a significant interaction between BMI and gender (p < 0.001). Among males, the incidence of major bleeding events was three times greater in obese/morbidly obese subjects as compared with normal/overweight male subjects (odds ratio [OR]: 3.09, 95% confidence interval [CI]: 1.25, 7.62). Among females, incidence of having a major bleeding event was almost two times greater in normal/overweight subjects as compared with obese/morbidly obese female subjects (OR: 2.17, 95% CI: 1.10, 4.35). Incidence of venous thromboembolism was 0.4% in each group. The authors' study results highlight a previously unexplored association between BMI and gender-dependent differences in bleeding outcomes when rivaroxaban is used for thromboprophylaxis following total joint arthroplasty.
Identifying, Analyzing, and Visualizing Diagnostic Paths for Patients with Nonspecific Abdominal Pain
Authors: Rao Goutham , Kirley Katherine , Epner Paul , Zhang Yiye , Bauer Victoria , Padman Rema , Zhou Ying , Solomonides Anthony 
Published: December 2018

Background Diagnosis is complex, uncertain, and error-prone. Symptoms such as nonspecific abdominal pain are especially challenging. A diagnostic path consists of diagnostic steps taken from initial presentation until a diagnosis is obtained or the evaluation ends for other reasons. Analysis of diagnostic paths can reveal patterns associated with more timely and accurate diagnosis. Visual analytics can be used to enhance both analysis and comprehension of diagnostic paths.
Objective This article applies process-mining methods to extract and visualize diagnostic paths from electronic health records (EHRs).
Methods Patient features, actions taken (i.e., tests, referrals, etc.), and diagnoses obtained for 501 adult patients (half female, half ≥50 years of age) presenting with abdominal pain were extracted from an EHR database to construct diagnostic paths from a hospital system in suburban Chicago, Illinois, United States. A stable diagnosis was defined as the same diagnosis recorded twice in a 12-month period; a working diagnosis was recorded only once. Three different types of path visualizations were obtained.
Results A stable diagnosis was obtained in 63 (13%) patients after 12 months. In 271 (54%) patients, a working diagnosis was obtained. Mean path duration was 145.3 days (standard deviation, 195.1 days). These 63 patients received 75 stable diagnoses.
Conclusion Structured EHR data can be used to construct diagnostic paths to gain insight into diagnostic practices for complaints such as abdominal pain.
Intra-articular Corticosteroids for Knee Pain—What Have We Learned from the Equine Athlete and Current Best Practice
Authors: Lattermann Christian , McIlwraith C. 
Published: December 2018

AbstractThe use of intra-articular corticosteroids for traumatic arthritis and osteoarthritis (OA) is common in the horse. The beneficial and deleterious effects of the principal corticosteroids used betamethasone esters (Celestone [Soluspan], methylprednisolone acetate [Depo Medrol], and triamcinolone acetonide [TA] [Vetalog or Kenalog]) have been defined for the horse. While TA has both disease-modifying as well as symptom-modifying effects, methyl prednisolone acetate has deleterious effects on the articular cartilage. Studies in traumatically injured joints show the same rationale (suppression of deleterious mediators associated with inflammation) and positive results from the use of TA in both equine and human patients. Studies in the experimental equine OA model allow for more in-depth knowledge of disease-modifying effects. Recent insights allow us to understand posttraumatic OA as an early consequence of joint injury that may require a more aggressive and proactive treatment approach than commonly applied to date.
Cytomegalovirus Screening in Pregnancy: A Cost-Effectiveness and Threshold Analysis
Authors: Albright Catherine M. , Werner Erika F. , Hughes Brenna L. 
Published: December 2018

Objective To determine threshold cytomegalovirus (CMV) infectious rates and treatment effectiveness to make universal prenatal CMV screening cost-effective.
Study Design Decision analysis comparing cost-effectiveness of two strategies for the prevention and treatment of congenital CMV: universal prenatal serum screening and routine, risk-based screening. The base case assumptions were a probability of primary CMV of 1% in seronegative women, hyperimmune globulin (HIG) effectiveness of 0%, and behavioral intervention effectiveness of 85%. Screen-positive women received monthly HIG and screen-negative women received behavioral counseling to decrease CMV seroconversion. The primary outcome was the cost per maternal quality-adjusted life year (QALY) gained with a willingness to pay of $100,000 per QALY.
Results In the base case, universal screening is cost-effective, costing $84,773 per maternal QALY gained. In sensitivity analyses, universal screening is cost-effective only at a primary CMV incidence of more than 0.89% and behavioral intervention effectiveness of more than 75%. If HIG is 30% effective, primary CMV incidence can be 0.82% for universal screening to be cost-effective.
Conclusion The cost-effectiveness of universal maternal screening for CMV is highly dependent on the incidence of primary CMV in pregnancy. If efficacious, HIG and behavioral counseling allow universal screening to be cost-effective at lower primary CMV rates.
Prevalence and Predictive Factors of Histopathological Complications in Children with Esophageal Atresia
Authors: Petit Laetitia-Marie , Righini-Grunder Franziska , Ezri Jessica , Jantchou Prevost , Aspirot Ann , Soglio Dorothée Dal , Faure Christophe 
Published: December 2018

Objectives Endoscopic follow-up after esophageal atresia (EA) tracheoesophageal fistula (TEF) repair is recommended to detect esophageal histopathological complications. We investigated the prevalence of histopathologically proven esophageal complications (peptic esophagitis, gastric metaplasia, and eosinophilic esophagitis) and assessed the predictors of these complications in children with EA-TEF.
Materials and Methods This is a prospective longitudinal cohort study performed between September 2005 and December 2014 comprising 77 children with EA-TEF followed-up until February 2017. Univariate analysis was performed using the Wilcoxon's rank-sum test for continuous variables and the Pearson's chi-square test for categorical variables. Multivariable analysis was performed using a Cox regression hazard model. The association between clinical factors and histopathologically proven complications was estimated using a Cox regression hazard model with time until the appearance of complications as the time scale.
Results All 77 children received proton pump inhibitors (PPIs) (n = 73) or H2 receptor antagonists (H2RA). A total of 252 endoscopies were performed in 73 children (median 2.6/child, range: 1–29). Median age at study completion was 4.9 years (range: 2.3–11.5 years). Histopathologically proven complications occurred in 38 children (52%): peptic esophagitis (n = 32, 44%), eosinophilic esophagitis (n = 15, 21%), and gastric metaplasia (n = 9, 12%). A total of 82% patients were on PPI or H2RA at the time of diagnosis of histological complication. Multivariable Cox regression analysis showed that patients with recurrent anastomotic strictures (>3 dilations) had a higher risk of occurrence of histopathologically proven complications over time (hazard ratio: 3.11, 95% confidence interval [CI]: 1.53–6.34). On univariate analysis, the result of the first endoscopy was not associated with the occurrence of histopathologically proven complications (odds ratio: 0.8, 95% CI: 0.16–3.95).
Conclusion Histopathologically proven complications with potential long-term consequences occurred in approximately 50% of children after EA-TEF repair. A history of recurrent anastomotic strictures is associated with the occurrence of these complications. The result of the first endoscopy does not predict the histopathological outcome. Children with EA-TEF warrant close and systematic long-term follow-up at specialized multidisciplinary clinics with endoscopic evaluation.
Can Platelet Mass Index Be a Parameter to Predict Intraventricular Hemorrhage in Very-Low-Birth-Weight Newborns?
Authors: Korkmaz Levent , Bastug Osman , Ozdemir Ahmet , Ceylan Mahir , Gunes Tamer , Ozturk Mehmet Adnan , Korkut Sabriye 
Published: December 2018

Objective Intraventricular hemorrhage (IVH) is an important problem in neonatal units not only in terms of its consequences but also its follow-up and the prediction of its emergence in newborns. In this study, we have compared platelet parameters such as platelet count (PC), mean platelet volume (MPV), and platelet mass index (PMI) in terms of IHV in very-low-birth-weight (VLBW) newborns. Thus, we have tried to determine platelet values to guide clinicians in both the prediction and follow-up of IVH.
Study Design This is a retrospective, multicenter, and case-controlled study. In this study, 386 cases of VLBW newborns (below 1,500 g) and gestational age below 32 weeks, hospitalized and monitored between August 8, 2012, and April 7, 2018, were included. The platelet values of the cases on their 12th hour postpartum (PC1, MPV1, and PMI1) and the platelet values on days 5 to 7 (PC2, MPV2, and PMI2) were recorded in their study cards. A p-value of <0.05 was accepted as statistically significant.
Results While there was no difference of PC1, MPV1, PMI1, PC2, or MPV2 values (p > 0.05), PMI2 values in the severe stage IVH group cases were found to be significantly lower compared with other platelet parameters (p < 0.05).
Conclusion PMI2 values can provide clinicians with important knowledge that may aid them in recognizing important pathologies such as IVH.
Diagnostik von Infektionskrankheiten
Authors: Knuf M. 
Published: December 2018

Zusammenfassung:Infektionskrankheiten kommen in der Pädiatrie sehr häufig vor. Die meisten Infektionen stellen typische Blickdiagnosen dar und können ohne aufwändige Labordiagnostik diagnostiziert werden. Fieber ist ein sehr häufiges Symptom und kann als diagnostisches Kriterium für Infektionskrankheiten (Atemwege, Gastrointestinaltrakt) genutzt werden. Es sind klinische Kriterien zur Unterscheidung viraler von bakteriellen Infektionen verfügbar. Daneben sind seltene, nicht infektiöse Ursachen für Fieber im Kindesalter zu berücksichtigen. Andere Infektionssymptome sind Exantheme, Lymphknotenvergrößerungen und Petechien. Manchmal ist die Diagnose auch erst im Verlauf zu stellen. Labormethoden zum Nachweis von Infektionen sind der direkte mikrobiologische Erregernachweis (Abstrich, Kultur), der molekularbiologische Erregernachweis (z. B. PCR), serologische Verfahren, erregerspezifische T-Zell-Stimulation, Antigen-Schnellteste sowie Biomarker („Hilfspa-rameter“) wie Blutbild, Differenzialblutbild, Akute-Phase-Proteine (z. B. C-reaktives Protein [CrP], Interleukine [z. B. Interleukin 6], Prokalzitonin [PCT] u. a.). Neben der Testqualität (Sensitivität, Spezifität) ist die Indikationsstellung zur Diagnostik von großer Bedeutung. Molekularbiologische Methoden und sogenannte Paneluntersuchungen gewinnen mehr und mehr an Bedeutung. Die klinische Relevanz ist oftmals noch unklar. Für die Diagnose einer Infektionskrankheit sind immer die Anamnese, das klinische Bild, die mikrobiologische bzw. virologische Befundlage sowie hilfsweise der Einsatz von Biomarkern geeignet. Daneben gilt es, die altersspezifische Epidemiologie von Erregern zu berücksichtigen.
Gas analysis of jian-gou mine goaf
Authors: Li Chengyu , Zhang Lili 
Published: December 2018

Abstract
Jiangou coal mine is a fully mechanized working face, with a height of 23 meters, serious air leakage in the goaf, easy spontaneous combustion of the coal seam, easy spontaneous combustion of the residual coal in the goaf. In order to prevent and control the spontaneous combustion fire in the goaf, we analyzed the thermal weight of B3 + 6 coal seam, obtains five characteristic temperature points. We conducted the heating and oxidation experiment of coal, analyzes the variation rule of the generated gas and its concentration with the temperature, and obtain the CO concentration distribution map of goaf based on the numerical simulation and on-site monitoring data.