bluuebunny/crossref_metadata_2025_split huggingface dataset:
Publication trends in pediatric renal transplantation: Bibliometric analysis of literature from 1950 to 2017
Authors: Rickard Mandy , Hannick Jessica H. , Fernandez Nicolas , Koyle Martin A. , MacMurdo Krista , Lorenzo Armando J. 
Published: May 2019

AbstractIntroductionPediatric renal transplantation has been heavily published since the 1950s. Herein, we describe the bibliometrics and impact of the 200 most‐cited pediatric renal transplantation manuscripts.MethodsWe identified pediatric renal transplantation publications from 1900 onwards. Year, citations, h‐index, geographic origin, impact factor, topic, and design of the 200 top‐cited papers were extracted. Impact index was calculated, adjusting for citation volume and time since publication.ResultsOf the top 200 papers, mean citation count was 80 ± 40, impact factor 3.9 ± 3.7, h‐index 35 ± 20, and impact index 25 ± 13. Studies were mostly retrospective (31%) or observational (32%). Most papers originated from the United States (58%), Germany (9%), and Italy (6%), which did not correlate with citation counts. Transplantation (18%), Pediatric Nephrology (16%), and American Journal of Transplantation (11%) had the highest publication volume, which did not correlate with citation count. The main topics were medical renal disease, drug monitoring, compliance, and viruses. Most of the top‐cited papers (179; 90%) were published after 1991. The difference in the number of times cited between papers published before and after 1991 was insignificant (75 ± 24 vs 80 ± 42; P = 0.59). There was a difference in impact index for the same period (48 ± 15 vs 22 ± 10; P < 0.01).ConclusionsThe most‐cited papers were concentrated in three journals, but the top three cited papers were published elsewhere. Recent publications were more cited with a higher impact than older papers. Despite the importance of surgery in transplantation, there is a paucity of high‐impact papers on this topic.
Human papillomavirus type 7‐associated anal condyloma after renal transplantation in a child
Authors: Garaix Florentine , Hery Geraldine , Tsimaratos Michel , Colson Philippe , Tamalet Catherine 
Published: May 2019

AbstractThe prevalence, clinical significance, and spectrum of many HPV genotypes are currently largely untapped. We report a case of anal condyloma associated with a rare HPV genotype in a 11‐year‐old kidney transplant recipient. Eleven months post‐graft, rectal bleeding revealed a 5‐cm‐large anal condyloma for which immuno‐histopathology revealed typical papillomatosis. HPV genotyping performed on anal biopsy identified a HPV type 7, for which a single sequence was found in the GenBank sequence database. HPV7 is classically found in hand cutaneous warts, but HPV7‐associated condyloma was only described in two patients. Total resection of the anal lesion was performed by electrocoagulation with no recurrence after 6 years. Post‐transplant immunosuppression may promote anal condyloma with uncommon HPV types. HPV genotyping in such lesions is useful to get a better understanding of the epidemiology and clinical significance of such unusual HPV types as HPV7.
Impact of physical activity and sport on social outcomes among Aboriginal and Torres Strait Islander people: a scoping review protocol
Authors: Macniven Rona , Canuto Karla , Wilson Rachel , Bauman Adrian , Evans John 
Published: May 2019

ABSTRACT

Objective:
The objective of this scoping review is to identify and describe existing research on the impact of sport and physical activity programs on social outcomes among Aboriginal and Torres Strait Islander people in Australia.

Introduction:
Physical activity can be particularly beneficial for groups such as Indigenous populations, who have increased rates of chronic disease. Systematic reviews have demonstrated the positive impact of physical activity on a range of health indicators, and there is also support for the positive impact of physical activity on wider social outcomes. However, there is a lack of evidence for the benefits of physical activity for broader social outcomes among Aboriginal and Torres Strait Islander people.

Inclusion criteria:
This scoping review will consider studies that include Aboriginal and Torres Strait Islander people of any age from any setting or region of Australia. Studies will be considered if they report on programs or activities that use physical activity and sport participation as a component or tool to improve one or more of six social and community outcomes: education, employment, culture, social wellbeing, life skills and crime prevention.

Methods:
Nine databases will be searched, as well as a selection of websites containing resources related to physical activity, sport and social outcomes for Aboriginal and Torres Strait Islander people. Studies published in English will be included. No date limits will be set. After screening the titles and abstracts of identified citations, potentially relevant studies will be retrieved in full. Data extraction will be presented in a table with accompanying narrative.
Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia
Authors: Adelman Emmalee R. , Huang Hsuan-Ting , Roisman Alejandro , Olsson André , Colaprico Antonio , Qin Tingting , Lindsley R. Coleman , Bejar Rafael , Salomonis Nathan , Grimes H. Leighton , Figueroa Maria E. 
Published: May 2019

AbstractAging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of epigenomic and transcriptomic changes, including single-cell RNA sequencing, during normal human aging. Lineage−CD34+CD38− cells [HSC-enriched (HSCe)] undergo age-associated epigenetic reprogramming consisting of redistribution of DNA methylation and reductions in H3K27ac, H3K4me1, and H3K4me3. This reprogramming of aged HSCe globally targets developmental and cancer pathways that are comparably altered in acute myeloid leukemia (AML) of all ages, encompassing loss of 4,646 active enhancers, 3,091 bivalent promoters, and deregulation of several epigenetic modifiers and key hematopoietic transcription factors, such as KLF6, BCL6, and RUNX3. Notably, in vitro downregulation of KLF6 results in impaired differentiation, increased colony-forming potential, and changes in expression that recapitulate aging and leukemia signatures. Thus, age-associated epigenetic reprogramming may form a predisposing condition for the development of age-related AML.Significance:AML, which is more frequent in the elderly, is characterized by epigenetic deregulation. We demonstrate that epigenetic reprogramming of human HSCs occurs with age, affecting cancer and developmental pathways. Downregulation of genes epigenetically altered with age leads to impairment in differentiation and partially recapitulates aging phenotypes.This article is highlighted in the In This Issue feature, p. 983
Introducing an Agenda-based Measurement of Mediation Success: The Divergent Effects of the Manipulation Strategy in African Civil Wars
Authors: Duursma Allard , Svensson Isak 
Published: May 2019

Abstract
Previous quantitative mediation research has relied on generalized measurements of “mediation success,” such as agreements, ceasefires or peace durability. However, these measurements of success do not take into account what mediators were mandated to achieve. We propose benchmarking outcomes against the explicit mandates of the interventions, a novel way of conceptualizing mediation success. Utilizing data on the agendas of mediated negotiations in intrastate armed conflicts in Africa between 1990 and 2010 as a proxy for mediation mandates, we examine the relative effectiveness of manipulation as a mediation strategy. The study shows, in contrast to previous research, that third party manipulation does not have a significant effect on whether the goal of a given round of negotiations is achieved and, that under some circumstances, may decrease the likelihood of mediation success. We discuss the opportunities as well as limitations of a mandate-based approach to the study of mediation success.
In Search of the True Faith: the Appearance of Orthodox Old Believers in Uganda and Spiritual Anti-globalism in Contemporary Africa
Authors: Bondarenko Dmitri M. 
Published: May 2019

Abstract
The present article, based on field evidence collected in 2017, deals with a very recent phenomenon — the Orthodox Old Believers in Uganda. This faith originated in Russia, however in Uganda all its adherents belong to African ethnic groups. We describe the short by now history and current state of the Old-Believer communities in Uganda and then concentrate on their members’ motivation for converting to Old Believers vs. knowledge of this religion. We show that what brings them to Old Believers is the search for the true faith associated with the original and hence correct way of performing Christian rites. In this we see an intricate interplay of the features typical for authentic African cultures and acquired by them in the course of interaction with the wider world. Basing on our case study, we discuss how globalist and anti-globalist trends manifest themselves in the religious context in contemporary Africa.
Poetic Record of Local Customs: Bamboo Branch Verses of Singapore (1888–1941)
Authors: Lam (林立) Lap 
Published: May 2019

Abstract
During the colonial period, Chinese poets in Singapore frequently adopted the short poetic genre called “Bamboo Branch Verse” to depict local customs, cultures, and their diasporic experiences. This genre has a folksong origin, and is traditionally used by literati writers to describe local folkways and secular love in exotic places. Li Qingnian’s Nanyang zhuzhici huibian shows that no fewer than 4,197 pieces were published in Malaya and Singapore from 1888 to 1950. Based on Li’s compilation yet adopting a more critical approach in handling his source materials, this article studies the content and generic style of Singapore’s zhuzhici and its relation to local society, from 1888, the year the first set of zhuzhici poems was published, to 1941, before Singapore was occupied by the Japanese army. It first reviews the tradition of zhuzhici writing and attempt to clarify its generic distinctiveness, so as to link the zhuzhici in Singapore with its origin and to point out what is new and unchanged. Second, it examines how writers used the miniature form of zhuzhici for social criticism and to respond to the colorful, complex Nanyang cultures. Finally, it focuses on Khoo Seok Wan’s poems to explicate the relationship between zhuzhici and print culture, his attitude toward local customs, and how he applied local languages, cyclic form, and explanatory notes in the genre.
Ismaili Onto-Cosmological Doctrines in the Manuscript Tradition of the Ikhwān al-Ṣafāʾ
Authors: Baffioni Carmela 
Published: May 2019

Abstract
This paper discusses Ismaili tendencies in some additions to the MSS of the Rasāʾil Ikhwān al-Ṣafāʾ consulted for the new edition of the encyclopaedia launched by the Institute of Ismaili Studies. Onto-cosmology is addressed in particular. The texts are in part copied from the Risāla al-Jāmiʿa and the Risāla Jāmiʿat al-Jāmiʿa. Sometimes they show similarities with Balīnūs, the Arabic pseudo-Apollonius of Tyana whom recent studies consider to play an important role in Ismaili thought. Though based on emanatism, onto-cosmology shares the religious terminology referred to hypostases; it introduces the concept of ibdāʿ besides that of emanation, the cosmic role of Imperative and the conception of God “beyond everything”; and it re-examines the Neoplatonic hypostases in the light of the Scriptural tale of Adam. Even if the additions were later interpolations, they demonstrate that the Ikhwān’s leaning towards Ismailism was a common belief at least in a certain manuscript tradition.
Developing Priority Observational Requirements from Space Using Multi-Attribute Utility Theory
Authors: Anthes Richard A. , Maier Mark W. , Ackerman Steve , Atlas Robert , Callahan Lisa W. , Dittberner Gerald , Edwing Richard , Emch Pamela G. , Ford Michael , Gail William B. , Goldberg Mitch , Goodman Steve , Kummerow Christian , Onsager Terrance , Schrab Kevin , Velden Chris , Vonderhaar Thomas , Yoe James G. 
Published: May 2019

AbstractOver a two-year period beginning in 2015, a panel of subject matter experts, the Space Platform Requirements Working Group (SPRWG), carried out an analysis and prioritization of different space-based observations supporting the National Oceanic and Atmospheric Administration (NOAA)’s operational services in the areas of weather, oceans, and space weather. NOAA leadership used the SPRWG analysis of space-based observational priorities in different mission areas, among other inputs, to inform the Multi-Attribute Utility Theory (MAUT)-based value model and the NOAA Satellite Observing Systems Architecture (NSOSA) study. The goal of the NSOSA study is to develop candidate satellite architectures for the era beginning in approximately 2030. The SPRWG analysis included a prioritized list of observational objectives together with the quantitative attributes of each objective at three levels of performance: a threshold level of minimal utility, an intermediate level that the community expects by 2030, and a maximum effective level, a level for which further improvements would not be cost effective. This process is believed to be unprecedented in the analysis of long-range plans for providing observations from space. This paper describes the process for developing the prioritized objectives and their attributes and how they were combined in the Environmental Data Record (EDR) Value Model (EVM). The EVM helped inform NOAA’s assessment of many potential architectures for its future observing system within the NSOSA study. However, neither the SPRWG nor its report represents official NOAA policy positions or decisions, and the responsibility for selecting and implementing the final architecture rests solely with NOAA senior leadership.
‘Menstrual blood is bad and should be cleaned’: A qualitative case study on traditional menstrual practices and contextual factors in the rural communities of far-western Nepal
Authors: Thapa Subash , Bhattarai Shivani , Aro Arja R 
Published: May 2019

Objective: Unhealthy menstrual practices and the contexts surrounding them should be explored and clearly understood; this information could be useful while developing and implementing interventions to increase hygienic practices during menstruation and consequently increase health and well-being of women. Therefore, this study was conducted to explore traditional menstrual practices and the contextual factors surrounding the practices in the rural communities of far-western Nepal. Methods: This was a qualitative case study conducted in the Achham district of Nepal. Semi-structured interviews were conducted among four women, three men and two female community health volunteers to collect data and thematic analysis was performed to analyze the data. Results: We found two commonly reported menstrual practices: seclusion practice (Chhaupadi) and separation practice. In the Chhaupadi practice, women are secluded to stay in a small shed away from the house and restricted to wash or take a bath in public water sources for 5–7 days of the periods, whereas in the separation practice, women can stay in the house, but they still have several restrictions. The contextual factors that were reported to influence the cultural practices are as follows: cultural beliefs that symbolize menstruation as impure, menstrual stigma, poverty, illiteracy, the influence of traditional healers and family members, and limited effect of Chhaupadi elimination interventions. We also found that some development in the reduction of cultural myths and practices is happening, but the rate of change is rather slow. Conclusion: Most of the Nepalese women, especially in the rural areas of far-western Nepal, are forced to follow the harmful menstrual practices because of the socio-cultural context surrounding their lives. We believe the findings of this study would be relevant in terms of developing and implementing further menstrual health-related, community-based interventions that will be responsive to the local cultural context, beliefs, and practices.
Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial
Authors: Falardeau Julie , Fryman Allison , Wanchu Rohan , Marracci Gail H , Mass Michele , Wooliscroft Lindsey , Bourdette Dennis N , Murchison Charles F , Hills William L , Yadav Vijayshree 
Published: May 2019

Background Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis. Optical coherence tomography can detect retinal nerve fiber layer thinning, representing axonal degeneration, approximately 3–6 months after acute optic neuritis. Objective To determine whether lipoic acid is neuroprotective in acute optic neuritis. Methods A single-center, double-blind, randomized, placebo controlled, 24-week trial. Intervention included 6 weeks of once daily lipoic acid (1200 mg) or placebo within 14 days of acute optic neuritis diagnosis. The primary outcome was the mean difference in affected eye retinal nerve fiber layer (RNFL) thickness from baseline to 24 weeks. Results We enrolled 31 subjects (placebo n=16; lipoic acid n=15; average age 38.6 years (standard deviation (SD) 10.3)). Affected eye mean global RNFL thickness (µm) in the lipoic acid group decreased from 108.47 (SD 26.11) at baseline to 79.31 (SD 19.26) at 24 weeks. The affected eye RNFL in the placebo group decreased from 103.67 (SD 18.04) at baseline to 84.43 (SD 20.94) at 24 weeks. Unaffected eye RNFL thickness did not significantly change in either group over 24 weeks. Conclusion Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.
Structural, functional and docking analysis against Schistosoma mansoni dihydroorotate dehydrogenase for potential chemotherapeutic drugs
Authors: Otarigho Benson 
Published: May 2019

Background:Praziquantel, as the only drug for the treatment of schistosomiasis, is under serious threat due to the emergence of resistant strains ofSchistosomaspecies. There is an urgent need to search for alternative chemotherapy to supplement or complement praziquantel.Schistosomadihydroorotate dehydrogenase (DHODH) has been recommended as a druggable target for schistosomiasis chemotherapy. The development of novel molecular modeling approaches, alongside with computational tools and rapid sequencing of pathogen genomes, have facilitated drug discovery. Therefore, the aim of this study was to employ computational approaches to screen compounds againstSchistosoma mansoniDHODH.Methods:In this study, DHODH was used to blast on the latest version of DrugBank that contained 12,110 compounds, resulting in 26 drugs that can bind.Results:In silicodocking shows that 13 drugs can bind strongly with an estimated free energy of binding, total intermolecular energy and estimated inhibition constant (Ki) greater than or equal to -8.6 kcal/mol, -8.12 kcal/mol and 1.12 µM, respectively. These compounds include the approved drugs manitimus, capecitabine, brequinar analog and leflunomide.Conclusions:These results indicate that these drugs have the potential for use in the control of schistosomiasis in the future.
Telomere length as a prognostic marker in colorectal cancer: a scoping review
Authors: Kim Gangmi , Lee Kang Young 
Published: May 2019

Background: Telomeres are protective structures at both ends of a chromosome, which consist of repetitive DNA sequences (TTAGGG). Maintenance of telomere length is known to have important roles in carcinogenesis. However, there is no consensus about the prognostic role of telomere length in colorectal cancer. Methods: We conducted a scoping review using Pubmed and EMBASE as information sources through April 2019. Inclusion criteria were studies investigating telomere length and prognosis of colorectal cancer. Selected studies were reviewed to reevaluate the significance of telomere length in the prognosis of colorectal cancer. The aim of the study was to summarize the previous studies, to find consistent results, and to suggest future research. Results: In total, 12 studies were identified and 1955 patients were included from 2004 to 2019. Among 10 studies with tissue samples, two studies revealed better prognosis in patients with longer telomere length, and only stage IV patients were recruited in these two studies; four studies revealed better prognosis in patients with shorter telomere length or lower ratio of telomere length between cancer and normal tissue; four studies did not show any significant association between tumor length and prognosis. Two studies with blood samples presented contradictory results regarding the correlation between telomere length and survival rate. Conclusions: There was no consistent evidence to prove the prognostic value of telomere length in colorectal cancer. However, in a subgroup with the metastatic disease only, longer telomere length of tumor tissue was significantly associated with superior prognosis. Multicenter prospective studies with a large sample size are needed to verify the prognostic value of telomere length in colorectal cancer.
Usefulness of Deep Learning Analysis for the Diagnosis of Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas
Authors: Kuwahara Takamichi , Hara Kazuo , Mizuno Nobumasa , Okuno Nozomi , Matsumoto Shimpei , Obata Masahiro , Kurita Yusuke , Koda Hiroki , Toriyama Kazuhiro , Onishi Sachiyo , Ishihara Makoto , Tanaka Tsutomu , Tajika Masahiro , Niwa Yasumasa 
Published: May 2019

OBJECTIVES:
Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic adenocarcinoma. Artificial intelligence (AI) is a mathematical concept whose implementation automates learning and recognizing data patterns. The aim of this study was to investigate whether AI via deep learning algorithms using endoscopic ultrasonography (EUS) images of IPMNs could predict malignancy.

METHODS:
This retrospective study involved the analysis of patients who underwent EUS before pancreatectomy and had pathologically confirmed IPMNs in a single cancer center. In total, 3,970 still images were collected and fed as input into the deep learning algorithm. AI value and AI malignant probability were calculated.

RESULTS:
The mean AI value of malignant IPMNs was significantly greater than benign IPMNs (0.808 vs 0.104, P < 0.001). The area under the receiver operating characteristic curve for the ability to diagnose malignancies of IPMNs via AI malignant probability was 0.98 (P < 0.001). The sensitivity, specificity, and accuracy of AI malignant probability were 95.7%, 92.6%, and 94.0%, respectively; its accuracy was higher than human diagnosis (56.0%) and the mural nodule (68.0%). Multivariate logistic regression analysis showed AI malignant probability to be the only independent factor for IPMN-associated malignancy (odds ratio: 295.16, 95% confidence interval: 14.13–6,165.75, P < 0.001).

DISCUSSION:
AI via deep learning algorithm may be a more accurate and objective method to diagnose malignancies of IPMNs in comparison to human diagnosis and conventional EUS features.