bluuebunny/crossref_metadata_2025_split huggingface dataset:
ІСТОРІЯ ЗАРОДЖЕННЯ, РОЗВИТКУ ТА ТЕПЕРІШНІЙ СТАН ФТИЗІАТРИЧНОЇ СЛУЖБИ НА КРЕМЕНЕЧЧИНІ
Authors: Piatnochka I. T. , Kornaha S. I. 
Published: May 2019

Мета: дослідити історію зародження, розвитку та теперішній стан фтизіатричної служби на Кременеччині.
Матеріали і методи. Проведено систематичний аналіз наукових джерел інформації щодо історії зародження, розвитку фтизіатричної служби на Кременеччині. Проаналізовано стан захворюваності на туберкульоз у Кременецькому районі у різні періоди боротьби з туберкульозом.
Результати. Наведено дані про зародження, розвиток як результат правильної організації роботи в боротьбі з туберкульозом: методи виявлення, консервативну протитуберкульозну терапію та хірургічне лікування туберкульозу легень, профілактичні протитуберкульозні заходи в різні періоди становлення фтизіатричної служби. А також її занепад, внаслідок теперішніх необґрунтованих реформ щодо фтизіатричної служби.
Висновки. Кременецький тубдиспансер розташований на території, яка ідеально підходить для лікування захворювань органів дихання. Зберігся невеликий за кількістю, але здібний, працьовитий медичний і допоміжний персонал, який бере за приклад вірне справжнє служіння хворим своїх попередників.
ПЕРСОНАЛІЗАЦІЯ В ОНКОЛОГІЇ: ІНДИВІДУАЛЬНИЙ ПІДХІД ДО ПРОФІЛАКТИКИ ТРОМБОЕМБОЛІЧНИХ УСКЛАДНЕНЬ ПРИ ПАНГІСТЕРЕКТОМІЇ
Authors: Zhulkevych I. V. , Kryvokulsky B. D. 
Published: May 2019

Мета: підвищити ефективність хірургічного лікування хворих на рак ендометрія шляхом оптимізації діагностичної тактики та хірургічної профілактики тромботичних ускладнень у ранній післяопераційний період.
Матеріали і методи. Обстежено 3 групи жінок: І – група 30 соматично здорових жінок; ІІ – контрольна група (група порівняння) – ретроспективно проаналізовано 120 карт стаціонарних хворих на рак ендометрія, яким виконано пангістеректомію в період 2010–2013 рр.; ІІІ – основна група жінок, хворих на рак ендометрія, яким виконували хірургічне втручання (пангістеректомію) – 147 хворих, які перебували на хірургічному лікуванні в 2014–2017 рр.
Результати. На першому етапі нашого дослідження проаналізовано основні антропометричні характеристики обстежених жінок і ризик виникнення тромботичних ускладнень за шкалою J. Сарrіnі. В основній групі обстежених і в групі порівняння виявлено зростання ризику виникнення тромбоемболій порівняно з групою здорових осіб, що вказувало на високий і вкрай високий ризик їх виникнення на операційному етапі лікування.
При вивченні гемостазіологічних показників в основній групі та групі порівняння у доопераційний, інтраопераційний і ранній післяопераційний періоди виявлено гіперкоагуляцію з ознаками внутрішньосудинного згортання, що проявлялась достовірним зниженням протромбінового індексу та скороченням ТЧ і АЧТЧ з одночасним підвищенням рівня ПЧ, ФГ, D-димеру. Ознаки гіперкоагуляції зростали під час операції та на 1–5 добу післяопераційного періоду і поступово знижувались до доопераційних значень, за винятком D-димеру, пік якого спостерігали на 8 добу післяопераційного періоду.
Створено і впроваджено в практику охорони здоров’я алгоритм оптимізації діагностичної та хірургічної профілактики тромбоемболій у хворих на рак ендометрія з врахуванням ризику їх виникнення.
Висновки. 1. Досягнуто зниження смертності в ранній післяопераційний період у хворих на рак ендометрія від тромбоемболії легеневої артерії з 4,17 до 0 % і післяопераційних тромботичних ускладнень – з 11,67 до 1,36 %.
2.Розроблено і впроваджено в клінічну практику алгоритм оптимізації діагностичної тактики та хірургічної профілактики можливих венозних тромбоемболічних ускладнень у хворих на рак ендометрія з урахуванням стану активності системи гемостазу та антропометричних даних і вмотивовано надано дієві практичні рекомендації.
Impaired Cardiovascular Magnetic Resonance–Derived Rapid Semiautomated Right Atrial Longitudinal Strain Is Associated With Decompensated Hemodynamics in Pulmonary Arterial Hypertension
Authors: Leng Shuang , Dong Yang , Wu Yang , Zhao Xiaodan , Ruan Wen , Zhang Gangcheng , Allen John C. , Koh Angela S. , Tan Ru-San , Yip James W. , Tan Ju Le , Chen Yucheng , Zhong Liang 
Published: May 2019

Background
The transition of right ventricle (RV) from a compensated to decompensated state contributes to survival in pulmonary arterial hypertension (PAH). This study investigates the significance of right atrial (RA) dysfunction on disease progression in PAH.

Methods

Eighty patients with PAH, including 58 with hemodynamically compensated RV function (PAH-C) and 22 with decompensated RV function (PAH-D), were compared with 80 age-matched and sex-matched normal controls. RA longitudinal strain and strain rate (SR) parameters corresponding to reservoir (total strain
ε

s

and strain rate SR
s
), conduit (passive strain
ε

e

and strain rate SR
e
), and booster pump (active strain
ε

a

and strain rate SR
a
) phases were derived by a rapid semiautomated method on cine cardiovascular magnetic resonance.

Results

In PAH compared with controls, significantly reduced RA strains and SRs were observed. Among patients with PAH, PAH-D had significantly impaired RA strains and SRs compared with PAH-C. RA total strain and passive strain were the best parameters for differentiating PAH-D from PAH-C. Lower RA strain correlated with increased RA pressure (
r
=−0.57;
P
<0.0001), RV volume (
r
=−0.37;
P
=0.002) and biomarker (
r
=−0.53;
P
<0.0001), impaired RV function (
r
=0.46–0.72;
P
<0.0001), and lower exercise capacity (
r
=0.41;
P
<0.0001). Reduced RA strains were significantly associated with higher risk of clinical worsening in PAH. RA passive strain was the best predictor of a composite adverse event end point (Harrell’s C statistic,0.75; hazard ratio,0.84;
P
=0.019) compared with other conventional RA and RV functional measurements.

Conclusions
RA phasic functions are impaired in PAH. Among patients with PAH, impaired RA strains reflect RV decompensation and higher risks and predict adverse clinical outcomes.

Clinical Trial Registration

https://www.clinicaltrials.gov
. Unique identifier: NCT02790918.
Diagnosing Moisture Sources for Flash Floods in the United States. Part I: Kinematic Trajectories
Authors: Erlingis Jessica M. , Gourley Jonathan J. , Basara Jeffrey B. 
Published: May 2019

Abstract
This study uses backward trajectories derived from North American Regional Reanalysis data for 19 253 flash flood reports during the period 2007–13 published by the National Weather Service to assess the origins of air parcels for flash floods in the conterminous United States. The preferred flow paths for parcels were evaluated seasonally and for six regions of interest: the West Coast, Arizona, the Front Range of the Rocky Mountains, Flash Flood Alley in south-central Texas, the Missouri Valley, and the Appalachians. Parcels were released from vertical columns in the atmosphere at times and locations where there were reported flash floods; these were traced backward in time for 5 days. The temporal and seasonal cycles of flood events in these regions are also explored. The results show the importance of trajectories residing for long periods over oceanic regions such as the Gulf of Mexico and the Caribbean Sea. The flow is generally unidirectional with height in the lower layers of the atmosphere. The trajectory paths from oceanic genesis regions to inland hotspots and their orientation with height provide clues that can assist in the diagnosis of impending flash floods. Part II of this manuscript details the land–atmosphere interactions along the trajectory paths.
Nasolacrimal Duct Management During Endoscopic Sinus and Skull Base Surgery
Authors: Rotsides Janine M. , Franco Alexa , Albader Abdullah , Casiano Roy R. , Lieberman Seth M. 
Published: May 2019

Objective: To evaluate rates of epiphora after transection and marsupialization of the nasolacrimal duct (NLD) during endoscopic sinus and skull base surgery. Introduction: The nasolacrimal canal forms part of the medial wall of the maxillary sinus. Transecting the NLD is sometimes necessary for tumor resection or surgical access to maxillary sinus and infratemporal fossa pathology. There is no consensus for the endoscopic management of the NLD when only the duct is transected without involving the nasolacrimal sac. Methods: Medical records of 29 patients from 2 academic institutions who underwent endoscopic sinus and skull base surgery with transection of the NLD were retrospectively reviewed. Whether the duct was marsupialized or simply transected was recorded, and the postoperative rate of epiphora was calculated. Results: Mean age was 59 years (range, 14-86 years). Mean follow-up was 10.5 months (range, 1-33 months). The NLD was marsupialized in 16 (55%) and simply transected in 13 (45%) patients. Six patients underwent postoperative radiation. No patients in the marsupialization group had epiphora postoperatively, all with Munk score of 0. One patient in the transection group developed postoperative epiphora with Munk score of 1. Pathology included inverted papilloma (8), acute on chronic inflammation (6), B-cell lymphoma (3), juvenile nasopharyngeal angiofibroma (2), squamous cell carcinoma (2), Schneiderian papilloma (2), metastatic melanoma (1), HPV-related carcinoma (1), adenocarcinoma (1), benign epithelial cyst (1), adenoid cystic carcinoma (1), and erosive chronic sinusitis without nasal polyposis (1). Conclusion: Management after transection of the NLD varies widely. The duct may be simply transected or marsupialized, or a formal dacryocystorhinostomy can be performed. The surgeon must also choose whether to place a stent. Based on our small series and review of the literature, marsupialization or simple transection of the NLD results in a low rate of postoperative epiphora in the setting of endoscopic sinus and skull base surgery.
Correlation of serum meteorin-like concentration with the presence and severity of obstructive sleep apnoea syndrome
Authors: Sun Huibo , Zhang Yanhua , Wang Jing , Kong Jie 
Published: May 2019

Objective Inflammatory processes that occur in subjects with obstructive sleep apnoea syndrome may contribute to progressive atherosclerosis and increased cardiovascular and cerebrovascular morbidity. Meteorin-like protein, which is also known as subfatin, is transcribed similarly to meteorin protein. Meteorin-like alleviates skeletal muscle inflammation. We aimed to investigate the serum meteorin-like status of obstructive sleep apnoea syndrome subjects and determine the potential link between serum meteorin-like concentration with the presence and severity of obstructive sleep apnoea syndrome. Methods The obstructive sleep apnoea syndrome group was composed of 207 obstructive sleep apnoea syndrome subjects diagnosed via polysomnography. A total of 106 healthy volunteers without clinical symptoms of obstructive sleep apnoea syndrome were recruited as the control group. Blood samples were obtained from all subjects to evaluate the serum meteorin-like concentrations via enzyme-linked immunosorbent assay method. Results Decreased serum meteorin-like concentration was found in obstructive sleep apnoea syndrome subjects compared with the controls. Serum meteorin-like concentration was associated with a reduced OR for having obstructive sleep apnoea syndrome (OR 0.97, 95% CI 0.961 to 0.98; P < 0.001). Severe obstructive sleep apnoea syndrome subjects showed significantly lower meteorin-like concentration compared with mild and moderate cases. Moderate subjects exhibited decreased serum meteorin-like concentration compared with mild cases. Pearson correlation analysis revealed that serum meteorin-like concentration was negatively correlated with obstructive sleep apnoea syndrome severity. Serum meteorin-like concentration negatively correlated with body mass index, low-density lipoprotein cholesterol, apnoea–hypopnea index, number of arousals, hypopnoea and apnoea in subjects with obstructive sleep apnoea syndrome. Conclusion Serum meteorin-like concentration is inversely correlated with the presence and severity of obstructive sleep apnoea syndrome.
Decomposition of Output and Productivity Growth in the Organised Manufacturing Industries in India: An Inter-State Analysis
Authors: Roy Prasanta Kumar 
Published: May 2019

This article examines and applies the theoretical foundation of the decomposition of output and total factor productivity growth (TFPG) of the aggregate manufacturing industries in 15 major industrialised states in India as well as in all-India during the period from 1981–1982 to 2010–2011, during the entire period, during the pre-reform period (1981–1982 to 1990–1991) and post-reform period (1991–1992 to 2010–2011), and also during two different decades of the post-reform period, that is, during 1991–1992 to 2000–2001 and 2001–2002 to 2010–2011. Output growth is decomposed into input growth effect and TFPG where the three attributes of TFPG are adjusted scale effect, technological progress (TP) and technical efficiency change. A stochastic frontier model with a translog production function is used to estimate the growth attributes of output and total factor productivity (TFP). The empirical results show that input growth is the major contributor to output growth, whereas TP is found to be the major contributor to TFPG and the decline in TFPG of the organised manufacturing sector in India and in its major industrialised states during the post-reform period is mainly due to the decline in TP of the same during that period. JEL Codes: C23, D24, L6, O47
Minimal volume ventilation during robotically assisted mitral valve surgery
Authors: Kesävuori Risto , Vento Antti , Lundbom Nina , Schramko Alexey , Jokinen Janne J , Raivio Peter 
Published: May 2019

Introduction: A minimal volume ventilation method for robotically assisted mitral valve surgery is described in this study. In an attempt to reduce postoperative pulmonary dysfunction, 40 of 174 patients undergoing robotically assisted mitral valve surgery were ventilated with a small tidal volume during cardiopulmonary bypass. Methods: After propensity score matching, 31 patients with minimal volume ventilation were compared with 54 patients with no ventilation. Total ventilation time, PaO2/FiO2 ratio, arterial lactate concentration, and the rate of unilateral pulmonary edema in the matched minimal ventilation and standard treatment groups were evaluated. Results: Patients in the minimal ventilation group had shorter ventilation times, 12.0 (interquartile range: 9.9-15.0) versus 14.0 (interquartile range: 12.0-16.3) hours (p = 0.036), and lower postoperative arterial lactate levels, 0.99 (interquartile range: 0.81-1.39) versus 1.28 (interquartile range: 0.99-1.86) mmol/L (p = 0.01), in comparison to patients in the standard treatment group. There was no difference in postoperative PaO2/FiO2 ratio levels or in the rate of unilateral pulmonary edema between the groups. Conclusion: Minimal ventilation appeared beneficial in terms of total ventilation time and blood lactatemia, while there was no improvement in arterial blood gas measurements or in the rate of unilateral pulmonary edema. The lower postoperative arterial lactate levels may suggest improved lung perfusion among patients in the minimal volume ventilation group. The differences in the ventilation times were in fact small, and further studies are required to confirm the possible advantages of the minimal volume ventilation method in robotically assisted cardiac surgery.
Cardiac Doppler in patients with primary varicose veins of lower extremities
Authors: Rusinovich Yury , Rusinovich Volha 
Published: May 2019

Aim This study examines the characteristics of cardiac Doppler in patients with primary varicose veins of lower extremities. Material and methods We performed retrospective descriptive statistical analysis of cardiac Doppler data of 85 patients with primary varicose veins and compared obtained parameters with normal values. Results Patients with primary varicose veins in comparison with normal controls have significantly lower early diastolic mitral and tricuspid inflow velocities (E wave), significantly higher late diastolic mitral and tricuspid inflow and annular velocities (A and a′ waves), significantly higher systolic mitral and tricuspid annular velocities (s′ wave), and they have normal early diastolic mitral and tricuspid annular velocities (e′ wave). Conclusion Cardiac Doppler in patients with primary varicose veins differs significantly from the actual normal values. Possible mechanism of this finding is compensatory increased atrial ejection fraction due to altered preload in patients with primary varicose veins.
Acceptability, tolerability, and effects on symptoms and signs of vulvovaginitis of a non-soap, herbal-based intimate hygiene solution (Zelesse®)
Authors: Guinot Misericordia , Blanco Jose Eliseo , Delgado Juan Luis , Oliva Raquel , Frutos Luis Manuel San , Huerta Ibone , Velasco Syra , Nieto Concepción 
Published: May 2019

Objective To evaluate the acceptability, tolerability, and effects on vulvovaginitis symptoms and signs of a non-soap, herbal-based intimate solution (Zelesse®). Methods We conducted a prospective, observational, multicenter study including adult women with symptoms and signs of vulvovaginitis with various etiologies, including candidiasis, trichomoniasis, bacterial vaginosis, and atrophic and irritative vaginitis. The presence and intensity of signs (edema, erythema, vaginal discharge) and symptoms (pruritus) of vulvovaginitis were evaluated before and after 5–15 days of daily use of Zelesse® alone or as a coadjuvant in antimicrobial therapy. Variables following a normal distribution and categorical variables were analyzed using the Student t-test and chi-square or Fisher’s exact test, respectively. Results A total 137 women were enrolled in the study; 87 (63.5%) women received concomitant antimicrobials and 50 (36.5%) used Zelesse® only. Global symptom scores and frequency of patients with vulvovaginitis signs and symptoms, and their mean intensity, decreased after treatment in both patient groups. Vaginal pH and (in the Zelesse®-only group) vaginal flora remained unaltered. The product was safe, well tolerated, and highly accepted by patients. Conclusions Zelesse®, the non-soap herbal-based solution in this study, may represent a safe and effective option for symptomatic relief of vulvovaginitis.
Blood Glucose Levels at Two Different Phases of Menstrual Cycle: A Study on a Group of Bengali-speaking Hindu Ethnic Populations of West Bengal, India
Authors: Dey Saheli , Dasgupta Doyel , Roy Subho 
Published: May 2019

Aim: We aimed to find out the blood sugar levels at two different phases of menstrual cycle and the factors associated with the change in blood sugar level at these different phases. Material and methods: A total of 60 Bengali-speaking Hindu participants, who were married, aged between 30 and 45 years, have regular menstruation, and not diagnosed as diabetic, were selected for this study. A structured questionnaire was used to collect data on sociodemographic, menstrual, reproductive, and lifestyle variables. Height (cm), weight (kg), and blood glucose level (mg/dl) were measured at two intervals of time: (a) during menstrual phase (between the 1st and 4th day) and (b) during luteal phase (between 19th and 22nd day of the cycle) following standard protocol. Bivariate analyses showed that majority of participants have increased blood glucose level at luteal phase as compared to their menstrual phase. Results: Results reveal that although BMI did not differ significantly between menstrual and luteal phases, there was a positive correlation between changed BMI value and changed blood glucose level measured during menstrual and luteal phases. Multivariate analysis revealed that blood glucose level increased with the increase in BMI level between two phases of menstrual cycle.
Effectiveness of a brief intervention aimed at increasing distress tolerance for individuals in crisis or at risk of self-harm
Authors: Yardley Priscilla , McCall Allira , Savage Alexandra , Newton Richard 
Published: May 2019

Objective: This study evaluated a brief psychological intervention aimed at improving distress tolerance and decreasing future admissions for individuals presenting to a mental health service in the context of crisis or self-harm. Methods: Eighty-five participants completed The Crisis Intervention Package at the point of contact with the mental health service. The outcome of the intervention was evaluated through pre- and post-scores on the Distress Tolerance Scale and future hospital admissions. Results: Participants showed a significant improvement in Distress Tolerance Scale scores ( P < 0.001) indicating an increase in ability to tolerate distressing emotions. Additionally, there was a significant decrease in hospital admissions 6 months pre-test to 6 months post-test. Conclusions: The results demonstrate the potential effectiveness of structured, brief interventions aimed at increasing distress tolerance and self-management skills for individuals presenting to a mental health service in crisis.
Effects of dexmedetomidine on glucose homeostasis in healthy cats
Authors: Bouillon Juliette , Duke Tanya , Focken Alexandra P , Snead Elisabeth C , Cosford Kevin L 
Published: May 2019

Objectives Alpha(α)2-agonist administration has been documented to increase blood glucose concentrations in many species. The aim of this study was to further describe the effect of dexmedetomidine on glucose and its regulatory hormones in healthy cats. Methods A randomized crossover study using eight healthy cats with a 14 day washout period was used to assess the effect of dexmedetomidine (10 μg/kg IV) and saline on glucose, cortisol, insulin, glucagon and non-esterified fatty acid (NEFA) concentrations at 0, 20, 60, 120 and 180 mins post-administration. Glucose:insulin ratios were calculated for each time point. Results Within the dexmedetomidine group, significant differences ( P <0.05) were detected: increased median (range) blood glucose concentrations at 60 mins (11.55 mmol/l [5.9–16.6 mmol/l]) and 120 mins (12.0 mmol/l [6.1–13.8 mmol/l]) compared with baseline (6.05 mmol/l [4.8–13.3 mmol/l]); decreased glucagon concentrations at 120 mins (3.8 pmol/l [2.7–8.8 pmol/l]) and 180 mins (4.7 pmol/l [2.1–8.2 pmol/l]) compared with baseline (11.85 pmol/l [8.3–17.2 pmol/l]); decreased NEFA concentrations at 60 mins (0.281 mmol/l [0.041–1.357 mmol/l]) and 120 mins (0.415 mmol/l [0.035–1.356 mmol/l]) compared with baseline (0.937 mmol/l [0.677–1.482 mmol/l]); and significantly larger ( P <0.05) glucose:insulin ratios at 60 mins compared with baseline. Insulin and cortisol concentrations were not significantly changed after dexmedetomidine administration. Conclusions and relevance Feline practitioners should be aware of the endocrine effects associated with the use of α2-agonists, particularly when interpreting blood glucose concentrations. The transient effects of dexmedetomidine on glucose homeostasis are unlikely to significantly affect clinical practice.