bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory blood biomarker response after controlled subconcussive head impacts: a pilot randomized controlled trial
Authors: Huibregtse Megan Elizabeth , Ejima Keisuke , Chen Zhongxue , Bevilacqua Zachary William , Koppineni Alekhya , Kalbfell Rachel M. , Kawata Keisuke 
Published: October 2019

Abstract
Background: Chronic neuroinflammation has been implicated as a possible contributing mechanism in the development and progression of chronic traumatic encephalopathy. This neurodegenerative condition has been associated with longterm, repetitive exposure to subconcussive head impacts, defined as head impacts that do not induce clinical signs or symptoms of concussion. However, there is a gap in knowledge surrounding the acute inflammatory response to subconcussive head impacts. The present study aimed to test our hypothesis that plasma levels of two proinflammatory markers (CCL11, CCL2) and one anti-inflammatory marker (IL-10) would be significantly elevated after 10 repetitions of controlled subconcussive head impacts. Methods: This randomized controlled trial included 39 healthy adult soccer players who were randomized into a heading (n=22) or kicking-control group (n=17). The heading group executed 10 headers with soccer balls projected at a speed of 25mph. The kicking-control group followed the same protocol with 10 kicks. Plasma samples were collected pre-, 0h post-, 2h post-, and 24h post-intervention. Samples were assayed for CCL11, CCL2, and IL-10, which are inflammatory markers that have shown to upregulate following traumatic brain injury. The longitudinal inflammatory marker data were analyzed using mixed-effect regression models. Results: There were no significant group differences in the changes of plasma CCL11, CCL2, or IL-10 levels at post-intervention time points as compared with pre-intervention baseline. However, within the heading group, there was a statistically significant interaction between time and years of soccer heading experience in plasma CCL11 levels at 24h post-intervention (2.0 pg/mL per a single year of soccer heading experience, 95% CI: 0.8, 3.1, p = 0.001). Conclusions: Ten soccer headings did not modulate the acute response in the three inflammatory marker levels compared against a kicking-control group. However, the acute CCL11 response may be influenced by the duration of prior exposure to subconcussive head impacts. Our data provide a precedent for future field studies that prospectively track head impact exposure and the time course of changes in circulating CCL11.
A Smart Glove Digital System Promotes Restoration of Upper Limb Motor Function and Enhances Cortical Neuroplastic Changes in Subacute Stroke Patients: A Randomized Controlled Trial
Authors: Lee Hwang-Jae , Chang Won Hyuk , Lee Ahee , Kim Hee-Goo , Ko Sung Hwa , Seong Hyun Yong , Shin Yong-Il , Kim Yun-Hee 
Published: October 2019

Abstract
Background: The sensor-based soft smart glove device is able to achieve multiple degree of freedom and complex motions with soft components. The purpose of this study was to examine the effects of RAPAEL ® Smart Glove digital training system on functional restoration of upper extremity and cortical neuroplastic changes in subacute stroke patients while provided in combined with conventional occupational therapy (OT).Methods: Fifty-two subacute stroke patients with upper extremity motor function deficit participated and 36 of them completed the interventional protocol (20 experimental group and 16 control group) . All participants were treated with conventional OT for 4 weeks, 5 times per week, 30 min per day. In addition, the experimental group received game-based digital hand motor training with the RAPAEL ® Smart Glove digital system for 4 weeks, 5 times per week, 30 min per day. The control group received additional OT for 30 min. The outcomes were assessed before intervention (T0), after 4 weeks of intervention (T1), and 4 weeks after cessation of intervention (T2) using Fugl-Meyer assessment (FMA) scale and Jebsen-Tayler hand function test (JTT). Oxygenated hemoglobin ( OxyHb ) levels over bilateral primary and secondary motor cortices during hand and wrist movement were measured using functional near infrared spectroscopy at T0 and T1.Results: All groups demonstrated improved upper extremity motor function for FMA total score and all subscores of JTT at T1, however, only experimental group showed further improvement at T2 ( p < 0.05). Also, the experimental group had significantly greater improvements upper extremity score of FMA scale and all subscores of JTT at T1 and T2 ( p < 0.05). Concentration of OxyHb over the ipsilesional sensorimotor cortex during wrist and hand movement was more increased in the experimental group than control group at T1 ( p < 0.05).Conclusion: This study demonstrated that training with the RAPAEL ® Smart Glove further improved upper extremity and hand motor function than conventional OT alone by enhancing ipsilesional motor cortical activity in subacute stroke patients.
Effect of ABO blood groups on response to warfarin
Authors: Zou Shan , Wu Lishan , Chen Zeliang , Li Hongxiao , Chen Hongjuan , Tan Xuerui , Yu Min 
Published: October 2019

Abstract
Background: Numerous studies have demonstrated that patients with non-O blood groups have higher risk for venous thromboembolism than those with O blood group. However, it has remained unknown about the effect of ABO blood groups on warfarin dose requirements in patients receiving anticoagulation in Chinese Han population. The study aimed to investigate the influence of ABO blood groups on warfarin dose requirements in Chinese Han population.
Methods: A retrospective study was conducted in the First Affiliated Hospital of Shantou University Medical College in Southern China. Three hundreds and 58 patients with confirmed diagnosis of deep venous thromboembolism and atrial fibrillation were included. Frequency of blood groups and warfarin dose requirements were determined.
Results: Of 358 patients with deep venous thromboembolism and atrial fibrillation, 111 patients had blood group A (31.01%), 104 patinets had blood group B (29.05%), 20 patients had blood group AB (5.59%), and 123 patients had blood group O (34.36%). The patients with O blood group had a lower warfarin dose requirements compared with those with A, B and AB blood group.
Conclusion: Our study showed that patients with non-O blood groups require higher doses of warfarin.
Management of button batteries in the upper gastrointestinal tract of children
Authors: gao yan , wang jin , ma jing , Gao Yingqin , Zhang Tiesong , Lei Puping , Xiong Xin 
Published: October 2019

Abstract
Background: To analyze the lodging locations of ingested button batteries in the upper gastrointestinal tract of children, common complications and treatment effects. Methods: The clinical data of 14 children with ingested button batteries lodged in the upper gastrointestinal tract were analyzed in our hospital between 2017 and 2019. Results: Among 10 children with ingested button batteries lodged in the first stenosis of esophagus, 9 were cured and 1 suffered from esophagotracheal fistula 12 days after removal. One child with the ingested button battery lodged in the second stenosis of esophagus was dead due to intercurrent aortoesophageal fistula 13 days after removal. Two cases had ingested button batteries lodged in the third stenosis of esophagus, and were cured after removal. The ingested button battery in 1 case was lodged in the gastrointestinal tract, and discharged spontaneously 1 day after hospital admission. Conclusions: Ingested button batteries are mainly lodged in the esophageal stenoses. Longer retention time could induce esophageal fistula. The ingested button battery in the gastrointestinal tract can discharge spontaneously.
Reactivity and reproducibility of accelerometer-based sedentary behavior and physical activity in two measurement periods: Results of a feasibility randomized-controlled study
Authors: Ullrich Antje , Baumann Sophie , Voigt Lisa , John Ulrich , Ulbricht Sabina 
Published: October 2019

Abstract
Background: The aims of the study were to investigate measurement reactivity in sedentary behavior (SB), physical activity (PA), and accelerometer wear time in two measurement periods, to examine the reproducibility of these outcomes and to quantify measurement reactivity as a confounder for the reproducibility of SB and PA data.Methods: A total of 136 participants (65% women, mean age = 54.6 years, study period 02/2015 to 08/2016) received 7-day accelerometry at baseline and after 12 months. Latent growth models were used to identify measurement reactivity in each period. Intraclass correlations (ICC) were calculated to examine the reproducibility using two-level mixed-effects linear regression analyses. Results: At both measurements periods, participants increased time spent in SB (b=2.3 min/d; b=3.8 min/d), reduced time spent in light PA (b=2.0 min/day; b=3.3 min/d), but did not change moderate-to-vigorous PA. Participants reduced accelerometer wear time (b=4.6 min/d) only at baseline. The ICC coefficients ranged from 0.42 (95% CI=0.29-0.57) for accelerometer wear time to 0.70 (95% CI=0.61-0.78) for moderate-to-vigorous PA. In none of the regression models, a reactivity indicator was identified as a confounder for the reproducibility of SB and PA data.Conclusions: The results show that measurement reactivity differentially influences SB and PA in two measurement periods. Although 7-day accelerometry seems to be a reproducible measure of SB and PA, our findings highlight the importance of accelerometer wear time as a crucial confounder when using accelerometry in monitoring SB and PA, planning interventions, and analyzing SB and PA data.Clinical trial registration number: NCT02990039 (retrospectively registered); December 12, 2016
Effect of gga-miR-155 on Cell Proliferation, Apoptosis and invasion of Marek’s disease Virus (MDV) transformed cell line MSB1 by targeting RORA
Authors: Ding Ke , Yu Zuhua , Yu Chuan , Jia Yanyan , He Lei , Liao Chengshui , Li Jing , Zhang Chunjie , Li Yingju , Wu Tingcai , Cheng Xiangchao , Zhou Zhiyu , Yu Zuling 
Published: October 2019

Abstract
Background: Marek's disease (MD) is an avian lymphoproliferative neoplasm caused by the oncogenic Marek's disease virus (MDV). MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in most cancers. The gga-miR-155 is downregulated in the MDV-infected chicken tissues or lymphocyte lines, although its exact role in tumorigenesis remains unclear. The aim of this study was to analyze the effects of gga-miR-155 on the proliferation, apoptosis and invasiveness of an MDV-transformed lymphocyte line MSB1 and elucidate the underlying mechanisms. Results: The expression level of gga-miR-155 was manipulated in MSB1 cells using specific mimics and inhibitors. While overexpression of gga-miR-155 increased proliferation, decreased the proportion of G1 phase cells relative to that in S and G2 phases, reduced apoptosis rates and increased invasiveness. However, its downregulation had the opposite effects. Furthermore, gga-miR-155 directly targetedthe RORA gene and downregulated its expression in the MSB1 cells.Conclusion: The gga-miR-155 promotes the proliferation and invasiveness of the MDV-transformed lymphocyte line MSB1 and inhibits apoptosis by targeting the RORA gene.
Trends of severe acute malnutrition morbidity and mortality (2014-2017), Bale Zone, Oromia Region, Ethiopia, 2018
Authors: Badeso Mohammed Hasen , Ferede Henok Asefa , Bogale Naod Berhanu , Kalil Falaho Sani 
Published: October 2019

Abstract
Background Malnutrition is a serious disease and remains an important public health problem in many developing countries including Ethiopia. Malnutrition is one of the diseases under the surveillance system which is reported weekly and monthly. In the Bale zone, malnutrition is one of the major public health problems. Therefore, this trend analysis of severe acute malnutrition was to describe the magnitude, trends, disease outcome and geographical distribution of the severe acute malnutrition in Bale Zone from 2014-2017.Methods A descriptive cross-sectional study was conducted on April 2018. Data was extracted from Bale zone monthly malnutrition report database and checked for completeness and consistency then four years’ trends of severe acute malnutrition were analyzed. The prevalence and trend of severe acute malnutrition by Woreda, year and age were analyzed using Microsoft office excel and SPSS version 20 then summarized using text, table, and figure.Result A total of 37,678 severe acute malnutrition cases registered over four years (2014-2017). Of these, 31,642(84%) cured, 52(0.14%) died, 641(1.7%) defaulters, 66(0.18%) non-respondents. Among registered cases, 98.2% are 6-59months age groups. The average annual prevalence of severe acute malnutrition high among under-five children was 3.3%. Prevalence rate per 1000 population of severe acute malnutrition in 2014, 2015,2016 and 2017 are 3.6, 4.5, 7.5 and 4.7 respectively and death rate are 0.21%, 0.26%, 0.1% and 0.08% respectively. Among the Woreda, the highest prevalence at Delomena (2.45%) and lowest at Sinana woreda (0.1%). The death rate is high among 6-59months age groups (0.13%) and followed by less than 6months age group (0.008%).Conclusion Cases of severe acute malnutrition increased during the year 2014 to 2016 then decreased during 2017. The prevalence of severe acute malnutrition high in under-five age groups children at Bale zone during the study period and Delomena Woreda has the highest average annual prevalence of severe acute malnutrition. We recommend further research on why some district has a high prevalence of severe acute malnutrition.
Suprapatellar versus infrapatellar approaches in the treatment of tibia intramedullary nailing: A retrospective cohort study
Authors: Cui Yiliang , Hua Xingyi , Schmidutz Florian , Zhou Jian , Yin Zongsheng , Yan Shuang G 
Published: October 2019

Abstract
Background: Tibial shaft fractures are routinely managed with intramedullary nailing (IMN). An increasingly accepted technique is the suprapatellar (SP) approach. The purpose of this study was to compare the clinical and functional outcomes of knee joint after tibia IMN through an suprapatellar (SP) or traditional infrapatellar (IP) approach. Methods: Retrospective analysis was performed in patients with tibial shaft fractures that were treated with tibia IMN through a SP or IP approach (1/2014-11/2016). The clinical and functional outcomes of knee joint were assessed with the Hospital for Special Surgery (HSS) Knee Score. Further evaluation included the operation time, intraoperative blood loss. Results: A total of 50 patients/fractures (26 IP and 24 SP) with a follow-up for a minimum of 15 months were evaluated. All fractures were OTA 42. No significant differences were found between the two groups in age, gender, side of fractures, operation time, intra-operative blood loss, and follow-up time. No significant difference was seen in HSS score ( P = 0.62) between them. Analysis of all the HSS components scores revealed no significant differences between them concerning the pain ( P = 0.57), the stand and walk ( P = 0.54), the need for walking stick ( P = 0.60) and extension lag ( P = 0.60). The other HSS components showed full scores (IP 10 vs. SP 10) in both approaches, including muscle force, flexion deformity and stability components. The range of motion (ROM) component score was superior in the IP group ( P = 0.04) suggesting a higher ROM. Conclusions: The SP and IP approaches can get equivalent knee functional outcomes in the treatment of tibial shaft fracture concerning the overall HSS knee score. However, for the HSS component, the IP approach was superior to SP approach regarding the ROM.
Utility of Magnetic Resonance Imaging in determining treatment response and local recurrence in Nasopharyngeal Carcinoma treated curatively
Authors: Meng Katherine , Tey Jeremy , Ho Francis , Asim Hira , Cheo Timothy 
Published: October 2019

Abstract
Background: To determine the optimal timing of the first Magnetic Resonance Imaging (MRI) scan after curative-intent radiotherapy (RT) for nasopharyngeal carcinoma (NPC), and evaluate the role of MRI in surveillance for locoregional recurrence (LRR).

Methods: Patients with non-metastatic NPC treated radically with at least one post-treatment MRI (ptMRI) were included for analysis. ptMRI reports were retrospectively reviewed and categorised as complete response (CR), partial response/residual disease (PR) or indeterminate (ID). Patients with LRR were assessed to determine if initial detection was by MRI or clinical means. Univariable and multivariable Cox proportional hazard regression analysis were performed to identify independent factors associated with CR on ptMRIs.

Results: Between 2013 and 2017, 262 eligible patients were analysed, all treated with Intensity Modulated Radiotherapy (IMRT). Median time from end of RT to the first ptMRI was 93 days (range 32-346). Of the first ptMRIs, 88 (33.2%) were CR, 133 (50.2%) ID, and 44 (16.6%) PR. A second ptMRI was done for 104 (78.2%) of 133 patients with ID status. In this group, 77 (57.9%) of the subsequent MRI were determined to be CR, 21(15.8%) remained ID and 6 (4.5%) PR. T1 tumour stage and AJCC stage I were associated with increased CR rates on first ptMRI on multivariable analysis. ID status was more likely at 75-105 days (3 months +/- 15 days) vs 106-135 days (4 months +/- 15 days) post RT (OR 2.13, 95% CI 1.16-4.12, p=0.024). LRR developed in 27 (10.1%) patients; 20 (74.1%) was initially detected through MRI, 3 (11.1%) by nasoendoscopy and 2 (7.4%) by PET-CT.

Conclusion: MRI is useful for detecting local recurrence or persistent disease after curative-intent treatment. Most patients will need more than one ptMRI to arrive at a definitive status. The rate of ID ptMRI may be reduced by delaying the first scan to around 4 months post RT.
Downregulated ZNF132 Predicts Unfavorable Outcomes in Breast Cancer via Hypermethylation Modification
Authors: Liu Zhao , Liu Jiaxin , Xue Man , Zhang Weifan , Zhao Xinhui , Xia Peng 
Published: October 2019

Abstract
Background: Methylation modification of tumor suppressor gene is one of the most critical mechanisms in human breast cancer (BC). Some biomarkers, including HER2, ER and PR, have been used in clinical practice, however, the effective was limited in terms of high recurrence and mortality rate. Thus, a better diagnostic and therapeutic target for BC is urgent. To date, no study provide information on the status of ZNF132 in BC or analyze diagnosis and prognostic significance of ZNF132 in BC. Methods: In the present study, we investigated the expression and clinical signifcance of ZNF132 by TCGA database and clinical samples analysis. Besides, a further exploration was performed to assess the molecular mechanisms of ZNF132 using the multiple bioinformatic tools. Importantly, a MSP assay was executed to confirm the epigenetic alteration of ZNF132. Results: Our results showed that the mRNA expression of ZNF132 was significantly downregulated in BC tissues, the consistent results was obtained by immunohistochemistry assessment. Importantly, survial analysis revealed that the lower expression of ZNF132 was remarkably correlated to Relapse Free Survival (RFS), but not Overall Survival (OS). Besides, the ROC curve confirmed ZNF132 had powerful sensitivity and specificity to distinguish between BC and adjacent normal tissues. Finally, MSP analysis demonstrated that ZNF132 was hypermethylated in BC tissues. Interestingly, ZNF132 methylation level was negatively correlated with its gene expression. Conclusions: Our results revealed that hypermethylation of ZNF132 contributed to its downregulated expression and could be identified as a new diagnostic and prognostic marker in BC.
Petri net Modeling and Property Analysis of C3 plant Photosynthesis and Photorespiration
Authors: Singh Gajendra Pratap , Jha Madhuri 
Published: October 2019

Abstract
Metabolic pathway - Modeling and Analysis, is the emerging research area in Biochemistry over the past few years.C3plants are the best carbohydrate producers and also are the most common plants found in the nature. These plants are very much efficient in photosynthesis in cool and wet climate while, in very hot climatic condition it undergoes photorespiration process. In this paper we model the process of making food by C3 plants to study the behavior in different climate conditions.
Efficacy of Bimin Decoction on patients with perennial allergic rhinitis: an open-label non-inferiority randomized controlled trial
Authors: Zhao Jingyi , Yan Xinyu , Gai Jianqing , Han Jinshuai , Zhang Hong , Luo Hui , Huang Shaoting , Wang Junge 
Published: October 2019

Abstract
Abstract
Background: Allergic rhinitis (AR) is a common allergic disease which affects people worldwide and traditional Chinese medicine is getting popular among AR patients for definite clinical effect and less adverse reactions. Lung qi deficiency and cold syndrome (LQDCS) is a frequent type of AR, and Chinese herbal medicine Bimin Decoction (BMD) was generated for AR patients with LQDCS. This study aimed to compare the clinical efficacy of BMD for AR patients with LQDCS to conventional medicine loratadine and fluticasone nasal spray.
Methods/Design: The study was designed as an open-label, non-inferiority, randomized controlled trial. A total of 108 AR patients with LQDCS aged 19 to 60 were 1:1 randomly allocated to BMD group and control group by central computer system in Beijing Hospital of Traditional Chinese Medicine from January 2017 to April 2018. 98 completed the study (n=51; n=47). Patients in BMD group received Bimin Decoction while the control group received fluticasone nasal spray and loratadine tablets for a 4-week treatment. The primary outcome was change of the Total Nasal Symptom Score (TNSS) at baseline and the end of treatment. Alterations in Rhinoconjunctivitis Quality Life quality Questionnaire (RQLQ), nasal resistance (NR) and acoustic rhinometry parameters were second outcomes. Any side effect of treatment was observed and recorded.
Results: After the 4-week treatment the TNSS total score was significantly reduced in both groups from baseline ( P < 0.05), no significant between-groups differences were observed for the changes of TNSS scores [-0.298 (95% CI -0.640 to 0.140)], which was within the defined non-inferiority margin. RQLQ in both groups decreased significantly ( P < 0.001) from baseline and more obvious reduction in BMD group was observed ( P < 0.001). There was no significant difference in the nasal resistance, the nasal volume and the nasal minimum cross-sectional area after treatment between groups ( P > 0.05).
Conclusions: These findings indicated that BMD helps relieve PAR symptoms and improve rhinitis-related life quality. Our study indicated that BMD is non-inferior to loratadine tablets and fluticasone nasal spray for AR patients with LQDCS.
Trial registration: Chinese Clinical Trial Registry, ChiCTR-INR-16010063. Registered on 2 December, 2016
Keywords: Perennial allergic rhinitis, Chinese traditional medicine, Randomized controlled trial, Clinical efficacy