bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empirical Bayes Meets Information Theoretical Network Reconstruction from Single Cell Data
Authors: Chan Thalia E. , Pallaseni Ananth V. , Babtie Ann C. , McEwen Kirsten R. , Stumpf Michael P.H. 
Published: February 2018

AbstractGene expression is controlled by networks of transcription factors and regulators, but the structure of these networks is as yet poorly understood and is thus inferred from data. Recent work has shown the efficacy of information theoretical approaches for network reconstruction from single cell transcriptomic data. Such methods use information to estimate dependence between every pair of genes in the dataset, then edges are inferred between top-scoring pairs. Dependence, however, does not indicate significance, and the definition of “top-scoring” is often arbitrary and apriorirelated to expected network size. This makes comparing networks across datasets difficult, because networks of a similar size are not necessarily similarly accurate. We present a method for performing formal hypothesis tests on putative network edges derived from information theory, bringing together empirical Bayes and work on theoretical null distributions for information measures. Thresholding based on empirical Bayes allows us to control network accuracy according to how we intend to use the network. Using single cell data from mouse pluripotent stem cells, we recover known interactions and suggest several new interactions for experimental validation (using a stringent threshold) and discover high-level interactions between sub-networks (using a more relaxed threshold). Furthermore, our method allows for the inclusion of prior information. We usein-silicodata to show that even relatively poor quality prior information can increase the accuracy of a network, and demonstrate that the accuracy of networks inferred from single cell data can sometimes be improved by priors from population-level ChIP-Seq and qPCR data.
Neo-formation of chromosomes in bacteria
Authors: Poirion Olivier B. , Lafay Bénédicte 
Published: February 2018

ABSTRACTAlthough the bacterial secondary chromosomes/megaplasmids/chromids, first noticed about forty years ago, are commonly held to originate from stabilized plasmids, their true nature and definition are yet to be resolved. On the premise that the integration of a replicon within the cell cycle is key to deciphering its essential nature, we show that the content in genes involved in the replication, partition and segregation of the replicons and in the cell cycle discriminates the bacterial replicons into chromosomes, plasmids, and another class of essential genomic elements that function as chromosomes. These latter do not derive directly from plasmids. Rather, they arise from the fission of a multi-replicon molecule corresponding to the co-integrated and rearranged ancestral chromosome and plasmid. All essential replicons in a distributed genome are thus neochromosomes. Having a distributed genome appears to extend and accelerate the exploration of the bacterial genome evolutionary landscape, producing complex regulation and leading to novel eco-phenotypes and species diversification.
The histone chaperone FACT coordinates H2A.X-dependent signaling and repair of DNA damage
Authors: Piquet Sandra , Parc Florent Le , Bai Siau-Kun , Chevallier Odile , Adam Salomé , Polo Sophie E. 
Published: February 2018

SUMMARYSafeguarding cell function and identity following a genotoxic stress challenge entails a tight coordination of DNA damage signaling and repair with chromatin maintenance. How this coordination is achieved and with what impact on chromatin integrity remains elusive. Here, by investigating the mechanisms governing the distribution of H2A.X in mammalian chromatin, we demonstrate that this histone variant is deposited de novo at sites of DNA damage in a repair synthesis-coupled manner. Our mechanistic studies further identify the histone chaperone FACT (Facilitates Chromatin Transcription) as responsible for the deposition of newly synthesized H2A.X. Functionally, FACT potentiates H2A.X-dependent signaling of DNA damage and, together with ANP32E (Acidic Nuclear Phosphoprotein 32 Family Member E), orchestrates a H2A.Z/H2A.X exchange reaction that reshapes the chromatin landscape at repair sites. We propose that this mechanism promotes chromatin accessibility and helps tailoring DNA damage signaling to repair progression.HIGHLIGHTSH2A.X, but not H2A.Z, is deposited de novo at sites of DNA damage repairFACT promotes new H2A.X deposition coupled to repair synthesisFACT and ANP32E chaperones orchestrate H2A.Z/H2A.X exchange in damaged chromatinFACT stimulates H2A.X-dependent signaling of DNA damage
TheC. elegansheterochronic genelin-28coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesis
Authors: Choi Sungwook , Ambros Victor 
Published: February 2018

AbstractC. elegansheterochronic genes determine the timing of expression of specific cell fates in particular stages of developing larva. However, their broader roles in coordinating developmental events across diverse tissues has been less well investigated. Here, we show that loss oflin-28, a central heterochronic regulator of hypodermal development, causes reduced fertility associated with abnormal somatic gonad morphology. In particular, the abnormal spermatheca-uterine valve morphology oflin-28(lf)hermaphrodites trap embryos in the spermatheca, which disrupts ovulation and causes embryonic lethality. The same genes that act downstream oflin-28in the regulation of hypodermal developmental timing also act downstream oflin-28in somatic gonad morphogenesis and fertility. Importantly, we find that hypodermal expression, but not somatic gonadal expression, oflin-28is sufficient for restoring normal somatic gonad morphology inlin-28(lf)mutants. We propose that the abnormal somatic gonad morphogenesis oflin-28(lf)hermaphrodites results from temporal discoordination between the accelerated hypodermal development and normally timed somatic gonad development. Thus, our findings exemplify how a cell-intrinsic developmental timing program can also control cell non-autonomous signaling critical for proper development of other interacting tissues.
Virtual reality as integration environments for facilities management
Authors: Carreira Paulo , Castelo Tiago , Gomes Cristina Caramelo , Ferreira Alfredo , Ribeiro Cláudia , Costa Antonio Aguiar 
Published: February 2018

Purpose
The purpose of this paper is to explore the use of virtual reality environments (VRE) for maintenance activities by augmenting a virtual facility representation and integrating relevant information regarding the status of systems and the space itself, while providing simple ways to control them.

Design/methodology/approach
The research focuses in the implementation of a VRE prototype of a building management system using game engine technologies. To evaluate the prototype, a usability study has been conducted that contrasts the virtual reality interface with a corresponding legacy application showing the users perception in terms of productivity improvement of facilities management (FM) tasks.

Findings
The usability tests conducted indicated that VREs have the potential to increase the productivity in maintenance tasks. Users without training demonstrated a high degree of engagement and performance operating a VRE interface, when compared with that of a legacy application. The potential drop in user time and increase in engagement with a VRE will eventually translate into lower cost and to an increase in quality.

Originality/value
To date no commonly accepted data model has been proposed to serve as the integrated data model to support facility operation. Although BIM models have gained increased acceptance in architecture engineering and construction activities they are not fully adequate to support data exchange in the post-handover (operation) phase. The presented research developed and tested a prototype able to handle and integrate data in a flexible and dynamic way, which is essential in management activities underlying FM.
Grey relational analysis for the AQI of Beijing, Tianjin, and Shijiazhuang and related countermeasures
Authors: Fu Bin , Gao Xiao Hui , Wu Lifeng 
Published: February 2018

Purpose
The purpose of this paper is to explore the relationship among the air quality index (AQI) of Beijing-Tianjin-Shijiazhuang region and find countermeasures to control the pollution situation.

Design/methodology/approach
This study used the grey convex relation model to calculate the grey correlation degree through the AQI of Beijing-Tianjin-Shijiazhuang region.

Findings
By analyzing the calculation results among the three cities, it was concluded that the air quality of the three cities is closely related. Therefore, the Beijing-Tianjin-Shijiazhuang region should collaboratively improve the air quality for common development.

Research limitations/implications
More approaches may be adopted to calculate the grey correlation degree in the further research studies.

Practical implications
There exist some practical difficulties in implementing these governance measures.

Originality/value
The paper gives the countermeasures to control the pollution situation in Beijing-Tianjin-Shijiazhuang region.
Witch-hunting, Cultural Revolution and the bright side of kinship
Authors: Deng Feng 
Published: February 2018

Purpose
Many studies on witch killings in Africa suggest that “witchcraft is the dark side of kinship.” But in Chinese history, where patriarchal clan system has been emphasized as the foundation of the society, there have been few occurrences of witch-hunting except a large-scale one in the Cultural Revolution in 1966. The purpose of this paper is to explain the above two paradoxes.

Design/methodology/approach
Theoretical analysis based on preference falsification problem with regard to the effect of social structure on witch-hunting is carried out.

Findings
There is a “bright side of kinship” due to two factors: first, it would be more difficult to pick out a person as qualitatively different in Chinese culture; second, the hierarchical trust structure embedded in the Chinese culture can help mitigate the preference falsification problem, which acts as the leverage for witch-hunting. In this sense, an important factor for the Cultural Revolution is the decline of traditional social institutions and social values after 1949.

Originality/value
This paper is the first to advance the two paradoxes and offer an explanation from the perspective of social structure.
Combining BP with PSO algorithms in weights optimisation and ANNs training for mass appraisal of properties
Authors: Yacim Joseph Awoamim , Boshoff Douw Gert Brand 
Published: February 2018

Purpose
The paper aims to investigate the application of particle swarm optimisation and back propagation in weights optimisation and training of artificial neural networks within the mass appraisal industry and to compare the performance with standalone back propagation, genetic algorithm with back propagation and regression models.

Design/methodology/approach
The study utilised linear regression modelling before the semi-log and log-log models with a sample of 3,242 single-family dwellings. This was followed by the hybrid systems in the selection of optimal attribute weights and training of the artificial neural networks. Also, the standalone back propagation algorithm was used for the network training, and finally, the performance of each model was evaluated using accuracy test statistics.

Findings
The study found that combining particle swarm optimisation with back propagation in global and local search for attribute weights enhances the predictive accuracy of artificial neural networks. This also enhances transparency of the process, because it shows relative importance of attributes.

Research limitations/implications
A robust assessment of the models’ predictive accuracy was inhibited by fewer accuracy test statistics found in the software. The research demonstrates the efficacy of combining two models in the assessment of property values.

Originality/value
This work demonstrated the practicability of combining particle swarm optimisation with back propagation algorithms in finding optimal weights and training of the artificial neural networks within the mass appraisal environment.
Technological appropriations as workarounds
Authors: Barrett Ashley Katherine 
Published: February 2018

PurposeThe purpose of this paper is to further adaptive structuration theory (AST) by associating technological appropriations with health information technology workarounds. The author argues that appropriating electronic health record (EHR) technology ironically – in a way other than it is designed to be used – and divergently across an organization results in enhanced perceptions of EHR technology and its implementation.Design/methodology/approachData were collected from 345 healthcare employees in a single healthcare organization that was switching to EHRs from paper records. Two major constructs of AST – unfaithfulness and dissension in appropriation – were operationalized and analyzed using multivariate regressions to test the relationship between the type of appropriation and perceptions of EHR technology’s relative advantage and implementation success.FindingsResults reveal that both ironic (unfaithful) technological appropriation and dissension in technological appropriation across the organization predicted employees’ perceptions of EHR’s relative advantage and perceptions of EHR implementation success. Furthermore, physicians are the least likely to perceive EHR’s relative advantage or EHR implementation success. These results exemplify that EHR workarounds are taking place and reaffirm AST’s principle that employees evolve technology to better suit their working environments and preferences.Originality/valueThe survey and scales used in this study further demonstrate that there are meaningful statistical measures to accompany the qualitative methods frequently used in the AST literature. In addition, this paper expands AST research by exploring the positive outcomes that follow ironic and divergent technology appropriations.
From virtual worlds to reality
Authors: Lee Yi-Hsuan , Hsieh Ying-Che , Hsiao Chan , Lin Chen-Hsiang 
Published: February 2018

PurposeThe purpose of this paper is to explore whether online leadership affects offline leadership through a mediation mechanism.Design/methodology/approachDrawing on social presence theory, the authors developed a mediation model of online leadership to offline leadership, and examine the moderating effect of interactivity. Data were collected through an internet questionnaire, with gamers in Taiwan’s leading forum as research targets. After receiving 912 valid questionnaires, the authors used SPSS 21 and AMOS 21 to conduct data analysis to test the model.FindingsThe results show that online leadership will affect offline leadership. Moreover, game achievements and character identification have partial mediated effects in this model. Finally, interactivity has a moderating effect in this model.Practical implicationsThese findings provide insights for future leadership training effectiveness, training guidelines, game design, and selection of references.Originality/valueThis research extends the current state of knowledge about the paths to transfer online leadership experiences to office situations through direct influence, game achievement, and character identification.
Using the technology acceptance model to predict patient attitude toward personal health records in regional communities
Authors: Razmak Jamil , Bélanger Charles 
Published: February 2018

Purpose
The purpose of this paper is to statistically measure (quantify) how a sample of Canadians perceives the usability of electronic personal health records (PHRs) and, in the process, to increase Canadian patients’ awareness of PHRs and improve physicians’ confidence in their patients’ ability to manage their own health information through PHRs.

Design/methodology/approach
The authors surveyed 325 Canadian patients living in Northern Ontario to assess a research model consisting of seven perceptions of PHR systems used to manage personal health information electronically, and to assess their perceived ability to use PHR systems. The survey questions were adapted from the 2014 National Physician Survey in Canada. The authors compared the patients’ results with physicians’ own perceptions of their patients’ ability to use PHR systems.

Findings
First, there was a positive relationship between surveyed patients’ prior experiences, needs, values, and their attitude toward adopting the PHR system. Second, how patients saw a PHR system’s user-friendliness was the strongest predictor of how useful they considered it would be. Finally, of the 243 physician respondents, 90.3 percent believed their patients would not be able to manage their own e-health information via a PHR system, but 54.8 percent of the 325 patient respondents indicated they would be able to do so.

Originality/value
This study is unique in that the authors know of no other Canadian study that purports to predict, using the technology acceptance model factors, people’s attitudes toward adopting a PHR system. As well, this is the first Canadian study to compare the perspectives of healthcare providers and their patients on e-health applications.
Understanding and managing knowledge transfer for customers in IT adoption
Authors: Daghfous Abdelkader , Belkhodja Omar , Ahmad Norita 
Published: February 2018

PurposeThe purpose of this paper is to advance information technology (IT) adoption research and practice by investigating the process of knowledge transfer (KT) undertaken by suppliers of IT innovations. The authors expound the intricacies of formal and informal mechanisms of the KT initiative that aims at augmenting the absorptive capacity (ACAP) of potential IT adopters with the objective of increasing the likelihood of adoption of new IT products or services.Design/methodology/approachThe authors draw on case studies of ten IT suppliers to build on the limited research on KT for customers in IT adoption. The authors focus on the for customer type of KT from the standpoint of the IT supplier firm.FindingsThe authors’ results show that complexity of the IT product or service increases the reliance on formal and systematic KT initiatives. This paper also shows that there is a required minimum threshold level of initial customers’ ACAP in order for the KT initiative to be worthwhile for the supplier, especially for those offering complex IT products and services. However, IT suppliers were found to limit their reliance on KT when they believed that customers that became too knowledgeable might threaten the innovation’s diffusion.Research limitations/implicationsSince the authors’ case firms represented innovation suppliers, future studies should investigate customer-supplier dyads to explore and integrate the customer’s perspective in the analysis of the KT process. To this end, longitudinal studies would also provide immense insights into the KT process and how it evolves over time.Originality/valueThe main contribution of this paper consists of illuminating the workings of KT initiatives aimed at existing and potential customers from the standpoint of the IT innovation supplier. By focusing on the for customers aspect of KT, this paper advances the authors’ understanding of why and how IT suppliers should resort to formal vs informal KT mechanisms. The authors’ proposed framework also integrates and shows the roles of customers’ ACAP, complexity of the IT innovation, and tacitness of the knowledge transferred to the customers.
Investigating Emirati citizens’ adoption of e-government services in Abu Dhabi using modified UTAUT model
Authors: Mansoori Khaled Ahmed Al , Sarabdeen Jawahitha , Tchantchane Abdel Latif 
Published: February 2018

Purpose
E-government is new to the public administration sector of Abu Dhabi and it is rapidly expanding. The purpose of this paper is to explore the factors that might motivate citizens to adopt the e-government public services provided by the Government of Abu Dhabi Emirate. The insights of the study will help government leaders to plan the delivery of public services effectively.

Design/methodology/approach
The study surveyed 638 United Arab Emirates (UAE) citizens living in three main districts of the Abu Dhabi Emirate. The research used an exploratory factor analysis that conforms the validity of the theoretical model to the data collected, confirmatory analysis to extract the latent factors and both multiple regression and structural equation modelling to test the research hypotheses.

Findings
The finding revealed that internet trust and performance expectancy was the strongest predictors of intention to use e-government services. Effort expectancy, facilitating conditions and trust had a positive influence on behavioural intention (BI). However, social influence (SI) did not have a significant effect. Gender, age and experience did not affect the relationship between SI and BI. It was also found that BI to use e-government services had a significant influence on the actual use of e-government sites.

Practical implications
When the government gets to know the major factors that affect the adoption of e-government services in Abu Dhabi, it can maximise its returns on ICT infrastructure investments by providing efficient service that could be adopted by the citizens.

Originality/value
The research has theoretical and practical value. Though the unified theory of acceptance and use of technology (UTAUT) model has previously been used in organisational settings, the present study uses a modified version in the context of citizens’ acceptance and use of e-government services. The present study thus provides an extension of the UTAUT model that could be suitable for developing countries such as the UAE.
Improving innovation performance through knowledge acquisition: the moderating role of employee retention and human resource management practices
Authors: Papa Armando , Dezi Luca , Gregori Gian Luca , Mueller Jens , Miglietta Nicola 
Published: February 2018

PurposeThis paper aims to study the effects of knowledge acquisition on innovation performance and the moderating effects of human resource management (HRM), in terms of employee retention and HRM practices, on the above-mentioned relationship.Design/methodology/approachA sample of 129 firms operating in a wide array of sectors has been used to gather data through a standardized questionnaire for testing the hypotheses through ordinary least squares (OLS) regression models.FindingsThe results indicate that knowledge acquisition positively affects innovation performance and that HRM moderates the relationship between knowledge acquisition and innovation performance.Originality/valueWith the increasing proclivity towards engaging in open innovation, firms are likely to face some tensions and opportunities leading to a shift in the management of human resources. This starts from the assumption that the knowledge base of the firm resides in the people who work for the firm and that some HRM factors can influence innovation within firms. Despite this, there is a lack of research investigating the link between knowledge acquisition, HRM and innovation performance under the open innovation lens. This paper intends to fill this gap and nurture future research by assessing whether knowledge acquisition influences innovation performance and whether HRM moderates such a relationship.