bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die endonasale endoskopische Resektion von Choanalatresien – wie groß ist der
Langzeiterfolg?
Authors: Holtmann Laura , Stähr Kerstin , Kirchner Julian , Lang Stephan , Mattheis Stefan 
Published: February 2018

Zusammenfassung
Einleitung Die Choanalatresie gehört zur Gruppe der seltenen Fehlbildungen. Sie stellt bei beidseitigem
Auftreten einen akut lebensbedrohlichen Notfall dar, da Neugeborene obligate Nasenatmer sind. Die
endoskopische Resektion ist eine etablierte Therapie, die Operationstechnik ist bisher jedoch nicht
standardisiert.
Methodik Die endonasal endoskopische Resektion von kongenitalen Choanalatresien bei 11 Kindern wurde
retrospektiv in einem Nachbeobachtungszeitraum von 9 bis 87 Monaten analysiert. Vier Kinder wiesen eine
bilaterale, sieben eine unilaterale Atresie auf. Neben der endoskopischen Resektion der Choanalatresie
erfolgten die Erweiterung der Choane durch endoskopisches Abtragen des Knochens Richtung Schädelbasis und das
Abtragen der hinteren Septumkante. Das intraoperative Handling, intra- und postoperative Komplikationen und
die Rezidivrate im Verlauf wurden ermittelt. Eltern bzw. Patienten wurden zur subjektiven Einschätzung der
Nasenatmung befragt.
Ergebnisse Intraoperative Komplikationen wurden keine beobachtet. Drei Frühgeborene wurden innerhalb der
ersten Lebenswoche bei einem durchschnittlichen Geburtsgewicht von 2540 g operiert. Postoperativ kam es
zweimal zu Schmierblutungen. Die langfristige Rezidivfreiheit lag bei 73 % (unilateral) bzw. 100 %
(bilateral).
Schlussfolgerungen Die endonasale endoskopische Resektion von Choanalatresien mit Erweiterung der Choane
Richtung Schädelbasis, Reduktion des Nasenbodens und Abtragen der hinteren Septumanteile stellt eine schonende
und erfolgreiche Therapieoption dar.
Single-channel recordings of RyR1 at microsecond resolution in CMOS-suspended membranes
Authors: Hartel Andreas J. W. , Ong Peijie , Schroeder Indra , Giese M. Hunter , Shekar Siddharth , Clarke Oliver B. , Zalk Ran , Marks Andrew R. , Hendrickson Wayne A. , Shepard Kenneth L. 
Published: February 2018

Significance
We present a method for measuring the conductance of ion channels at bandwidths up to 500 kHz by fabricating lipid membranes directly on the surface of a custom amplifier chip. We apply this approach to the RyR1 receptor, enabling us to identify additional closed states for calcium-dependent inactivation at microsecond temporal resolutions. Additional data analysis using extended beta distributions allows us to detect gating events as short as 35 ns, a timescale that approaches that of single-file ion translocation. These measurement techniques hold the promise of reaching timescales for studying the kinetics of ion channels, achievable now only with computer-based molecular dynamics simulations.
Endocytosis as a stabilizing mechanism for tissue homeostasis
Authors: Adler Miri , Mayo Avi , Zhou Xu , Franklin Ruth A. , Jacox Jeremy B. , Medzhitov Ruslan , Alon Uri 
Published: February 2018

SignificanceMany tissues in the body constantly turn over as cells divide and are replaced within weeks. Despite this turnover, tissues are able to keep proper ratios of their different cell types. How tissues attain this balance, called homeostasis, is unclear. Here we show that homeostasis can be achieved by circuits of cells that signal to each other using diffusible signals. A key negative feedback loop that stabilizes these circuits is endocytosis, a common feature of biological signaling in which a cell takes up and degrades the signal molecule that makes it divide and survive. Thus, the more of that cell type the less its numbers increase.
Impact of local symmetry breaking on the physical properties of tetrahedral liquids
Authors: Shi Rui , Tanaka Hajime 
Published: February 2018

Significance
Water and silica are quite important for human beings because they are the most abundant materials with tremendous biological, geological, and technological significance. They show similar density anomalies and crystalline structures but also have differences: Water crystallizes easily on cooling, but not silica, which has a significant impact on our planet. These similarities and differences have been known for a long time, but a clear microscopic explanation is still missing. Here, we successfully reveal the microscopic physical origin of the similarities and differences between water and silica, from the local symmetric arrangement of atoms in these liquids. Our finding indicates the importance of detailed characterization of low-energy local structures for understanding the properties of liquids interacting with directional bond.
Corrosion and fouling behaviours of copper-based superhydrophobic coating
Authors: Lv Yan , Liu Mingyan 
Published: February 2018

A preparation technology of superhydrophobic coating on copper substrate was studied. Surface morphology and wettability of the superhydrophobic coating were characterised. The preparation mechanism was analysed. Corrosion and fouling behaviours of the superhydrophobic coating were investigated by electrochemical workstation and immersion experiments. The results show that ultrasonic assistance can shorten etching time and improve the etching uniformity of copper substrate. The optimum fabrication process parameters of superhydrophobic coating on copper substrate were obtained. The concentration of octadecanoic acid in the ethanol solution is 0.02 mol  L−1, the immersion temperature is 35°C and the immersion time is 120 h. Under these conditions, micro–nano long-strip structure can be formed on the surface of copper substrate, and the static contact angle can be up to 157° and contact angle hysteresis is 4.2°. The superhydrophobic coating shows better anti-corrosion and anti-fouling properties on copper substrate compared with the surface of bare copper.
Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet's disease severity
Authors: Kahraman Tamer , Gucluler Gozde , Simsek Ismail , Yagci Fuat Cem , Yildirim Muzaffer , Ozen Can , Dinc Ayhan , Gursel Mayda , Ikromzoda Lolai , Sutlu Tolga , Gay Stephen , Gursel Ihsan 
Published: February 2018

ABSTRACTBehçet's disease (BD) activity is characterised by sustained, over‐exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived antimicrobial peptide LL37 associates with and directs plasma extracellular vesicles (EV) to immune cells, thereby leading to enhanced immune activation aggravating BD pathology. Notably, disease activity was correlated with elevated levels of circulating LL37 and EV plasma concentration. Stimulation of healthy PBMC with active BD patient EVs induced heightened IL1β, IFNα, IL6 and IP10 secretion compared to healthy and inactive BD EVs. Remarkably, when mixed with LL37, healthy plasma‐EVs triggered a robust immune activation replicating the pathology inducing properties of BD EVs. The findings of this study could be of clinical interest in the management of BD, implicating LL37/EV association as one of the major contributors of BD pathogenesis.Abbreviations: BD: Behçet's disease; EV: extracellular vesicle; BB: binding buffer; AnV: annexin V; autologEV: autologous extracellular vesicles; alloEV: allogeneic extracellular vesicles
Synthesis of Nanomaterials by the Pulsed Plasma in Liquid and their Bio-medical Applications
Authors: Omurzak E , Abdullaeva Z , Satyvaldiev A , Zhasnakunov Z , Kelgenbaeva Z , Adil Akai Tegin R , Syrgakbek kyzy D , Doolotkeldieva T , Bobusheva S , Mashimo T 
Published: February 2018

Abstract
Pulsed plasma in liquid is a simple, ecologically friendly, cost-efficient method based on electrical discharge between two metal electrodes submerged into a dielectric liquid. We synthesized carbon-encapsulated Fe (Fe@C) magnetic nanoparticles with low cytotoxicity using pulsed plasma in a liquid. Body-centered cubic Fe core nanoparticles showed good crystalline structures with an average size between 20 and 30 nm were encapsulated in onion-like carbon coatings with a thickness of 2–10 nm. Thermal gravimetric analysis showed a high stability of the as-synthesized samples under thermal treatment and oxidation. Cytotoxicity measurements showed higher cancer cell viability than samples synthesized by different methods. Carbon coated ZnO nanorods with about 20 nm thickness and 150 nm length were synthesized by this method using different surfactant materials such as cetyl trimethylammonium bromide (CTAB) and sodium dodecyl sulphate (SDS). Cu and Ag nanoparticles of about 10 nm in size were also synthesized by the pulsed plasma in aquatic solution of 0.2 % gelatine as surfactant material. These nanoparticles showed high antibacterial activity for Erwinia amylovora and Escherichia coli.
Comparative Efficacy of Antihypertensive Agents in Salt-Sensitive Hypertensive Patients: A Network Meta-Analysis
Authors: Qi Han , Liu Zheng , Cao Han , Sun Wei-Ping , Peng Wen-Juan , Liu Bin , Dong Sheng-Jie , Xiang Yu-Tao , Zhang Ling 
Published: February 2018

Abstract

BACKGROUND
Salt-sensitive hypertension (SSH) is an intermediate inherited phenotype of essential hypertension as well as being an independent risk factor for cardiovascular disease. However, effective medications for the treatment of SSH have not been clarified. This study was to compare the efficacious of different classes of antihypertensive agents combined with salt intake on the reduction of blood pressure (BP) in patients with SSH.

METHODS
We used sources as PubMed, EMBASE, Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), CNKI, and WANFANG database from inception to November 2016. Studies that compared the efficacy of 2 or more antihypertensive agents or placebos in adult salt-sensitive hypertensive patients were included. The outcomes included variations in mean arterial blood pressure, systolic and diastolic blood pressure.

RESULTS
Twenty-five studies were involved in this meta-analysis. A calcium channel blocker (CCB) with hydrochlorothiazide and moderate salt intake was significantly the most efficacious in comparison with placebo (standardized mean differences (SMD), 95% credibility intervals (CI): 26.66, 12.60 to 40.16), angiotensin receptor blockers (ARBs) (SMD, 95% CI: 22.94, 5.26 to 40.51), and the other interventions for patients with SSH and no concomitant diseases. For SSH patients who were obese, CCB with metformin and moderate salt intake would decrease blood pressure with 17.90 mm Hg.

CONCLUSIONS
For SSH patients with no concomitant diseases, CCB combined with hydrochlorothiazide and moderate salt intake was optimal in reducing BP, while CCB combined with metformin and moderate salt intake was the most efficacious at reducing BP in SSH patients with coexisting obesity.
Advanced lesion symptom mapping analyses and implementation as BCBtoolkit
Authors: Foulon Chris , Cerliani Leonardo , Kinkingnéhun Serge , Levy Richard , Rosso Charlotte , Urbanski Marika , Volle Emmanuelle , Thiebaut de Schotten Michel 
Published: February 2018

Abstract

Background
Patients with brain lesions provide a unique opportunity to understand the functioning of the human mind. However, even when focal, brain lesions have local and remote effects that impact functionally and structurally connected circuits. Similarly, function emerges from the interaction between brain areas rather than their sole activity. For instance, category fluency requires the associations between executive, semantic, and language production functions.

Findings
Here, we provide, for the first time, a set of complementary solutions for measuring the impact of a given lesion on the neuronal circuits. Our methods, which were applied to 37 patients with a focal frontal brain lesions, revealed a large set of directly and indirectly disconnected brain regions that had significantly impacted category fluency performance. The directly disconnected regions corresponded to areas that are classically considered as functionally engaged in verbal fluency and categorization tasks. These regions were also organized into larger directly and indirectly disconnected functional networks, including the left ventral fronto-parietal network, whose cortical thickness correlated with performance on category fluency.

Conclusions
The combination of structural and functional connectivity together with cortical thickness estimates reveal the remote effects of brain lesions, provide for the identification of the affected networks, and strengthen our understanding of their relationship with cognitive and behavioral measures. The methods presented are available and freely accessible in the BCBtoolkit as supplementary software [1].
Geostatistical regularization operators for geophysical inverse problems on irregular meshes
Authors: Jordi C , Doetsch J , Günther T , Schmelzbach C , Robertsson J OA 
Published: February 2018

Summary
Irregular meshes allow to include complicated subsurface structures into geophysical modelling and inverse problems. The non-uniqueness of these inverse problems requires appropriate regularization that can incorporate a priori information. However, defining regularization operators for irregular discretizations is not trivial. Different schemes for calculating smoothness operators on irregular meshes have been proposed. In contrast to classical regularization constraints that are only defined using the nearest neighbours of a cell, geostatistical operators include a larger neighbourhood around a particular cell. A correlation model defines the extent of the neighbourhood and allows to incorporate information about geological structures. We propose an approach to calculate geostatistical operators for inverse problems on irregular meshes by eigendecomposition of a covariance matrix that contains the a priori geological information. Using our approach, the calculation of the operator matrix becomes tractable for 3-D inverse problems on irregular meshes. We tested the performance of the geostatistical regularization operators and compared them against the results of anisotropic smoothing in inversions of 2-D surface synthetic electrical resistivity tomography (ERT) data as well as in the inversion of a realistic 3-D cross-well synthetic ERT scenario. The inversions of 2-D ERT and seismic traveltime field data with geostatistical regularization provide results that are in good accordance with the expected geology and thus facilitate their interpretation. In particular, for layered structures the geostatistical regularization provides geologically more plausible results compared to the anisotropic smoothness constraints.
Maintenance of Certification: Perceptions and Attitudes of Neurosurgeons
Authors: Babu Maya A , Liau Linda M , Connolly E Sander , Meyer Fredric B 
Published: February 2018

Abstract
Assuring clinical competence throughout the career of a neurosurgeon is of paramount importance for patient safety. We present the first comprehensive survey of all neurosurgeons board certified through the American Board of Neurological Surgery (ABNS) to evaluate perceptions of Maintenance of Certification (MOC). We administered a validated, online, confidential survey to 4899 neurosurgeons (2435 ABNS diplomates participating in MOC, 1440 diplomates certified prior to 1999 [time-unlimited certificates], and 1024 retired diplomates). We received 1449 responses overall (30% response rate). Our study found that most respondents believe that neurosurgeons should be required to participate in continuing professional improvement following initial board certification (75%). Most believe that specialty boards, working in conjunction with specialty societies, should require diplomates to participate in programs meant to promote continuous professional development (73%). The majority of respondents (76%) believed that self-assessment tests constituted a meaningful professional development activity, in addition to periodic case log reviews (33%) or quality improvement projects (32.6%). A plurality of respondents (44%) do not feel that the MOC process as currently structured provides them with value. There were no differences between those who were “grandfathered” and those who actively participate in MOC and no differences between those in private practice versus those in academics. The ABNS is cognizant of diplomate concerns and is actively developing new MOC paradigms to ensure that the process achieves both the goals of meeting the public interest and assuring that the quality of American neurosurgery remains exemplary.
Appendiceal Endometriosis and Ectopic Pregnancy Occurring Simultaneously
Authors: Chemerinski Anat , Lubin Daniel , Holder Sevelle , Shah Divya 
Published: February 2018

BACKGROUND:
In the setting of a known ectopic pregnancy, severe abdominal pain with clinical concern for rupture is an indication for emergency surgery. In rare cases, appendiceal pathology may occur simultaneously.

CASE:
A woman with a known ectopic pregnancy presented to the emergency department with a clinical picture consistent with its rupture. At the time of surgery, an appendectomy also was performed owing to concern for concurrent appendicitis; histopathologic examination revealed appendiceal endometriosis.

CONCLUSION:
During surgical management of ectopic pregnancy, it is important to undertake a thorough examination of the pelvis, because patients may present with multiple concurrent pathologies. In the setting of an emergency operation, when the diagnosis seems clear, this survey should not be forgotten.
Rate of Pelvic Organ Prolapse Surgery Among Privately Insured Women in the United States, 2010–2013
Authors: Sammarco Anne G. , Swenson Carolyn W. , Kamdar Neil S. , Kobernik Emily K. , DeLancey John O. L. , Nallamothu Brahmajee , Morgan Daniel M. 
Published: February 2018

OBJECTIVE:
To analyze utilization of, and payments for, pelvic organ prolapse procedures after the 2011 U.S. Food and Drug Administration (FDA) communication regarding transvaginal mesh.

METHODS:
This is a retrospective cohort study examining private claims from three insurance providers for inpatient and outpatient prolapse procedures from 2010 to 2013 in the Health Care Cost Institute. Primary outcomes were the change in utilization of prolapse procedures, with and without mesh, before and after the July 2011 FDA communication. Secondary outcomes were the changes in payments and reimbursements for these procedures. Utilization rates and payments were compared using generalized linear models and interrupted time-series analysis.

RESULTS:
Utilization of prolapse procedures decreased from 12.3 to 9.7 per 10,000 woman-years (P=.027) with a decrease of 30.7% (3.9 in 2010 to 2.7 in 2013, P=.05) in number of mesh procedures and 16.6% (8.4 in 2010 to 7.0 in 2013, P=.011) for nonmesh procedures. Quarterly utilization of mesh procedures was increasing before the FDA communication and then significantly declined after its release (slope=0.024 vs −0.025, P=.002). Nonmesh procedures, however, were already slightly decreasing before July 2011 and continued to decline at a more rapid pace after that time, although not significantly (slope=−0.004 vs −0.022, P=.47). Inpatient utilization decreased 52.2% (P=.002), whereas outpatient utilization increased 18.5% (P=.132). Payments for individual inpatient procedures, with and without mesh, increased by 12.0% ($8,315 in 2010 to $9,315 in 2013, P=.001) and 15.6% ($7,826 in 2010 to $9,048 in 2013, P=.005), respectively, whereas those for outpatient procedures increased by 41% ($4,961 in 2010 to $6,981 in 2013, P=.006) and 30% ($3,955 in 2010 to $5,149 in 2013, P=.004), respectively.

CONCLUSION:
Use of prolapse surgery declined during the study period. After the 2011 FDA communication regarding transvaginal mesh, there was a significant decrease in the utilization of procedures with mesh but not for those without mesh. A shift toward outpatient surgeries was observed, and payments for both individual inpatient and outpatient cases increased.
Risk of Adverse Pregnancy Outcomes at Advanced Maternal Age
Authors: Frederiksen Line Elmerdahl , Ernst Andreas , Brix Nis , Braskhøj Lauridsen Lea Lykke , Roos Laura , Ramlau-Hansen Cecilia Høst , Ekelund Charlotte Kvist 
Published: February 2018

OBJECTIVE:
To study the possible associations between advanced maternal age and risk of selected adverse pregnancy outcomes.

METHODS:
The study used a nationwide cohort of 369,516 singleton pregnancies in Denmark followed from 11–14 weeks of gestation to delivery or termination of pregnancy. Pregnant women aged 35 years or older were divided into two advanced maternal age groups, 35–39 years and 40 years or older, and compared with pregnant women aged 20–34 years. Adverse pregnancy outcomes were chromosomal abnormalities, congenital malformations, miscarriage, stillbirth, and birth before 34 weeks of gestation. Multivariable logistic regression analyses were performed to investigate associations between advanced maternal age and adverse pregnancy outcomes. Furthermore, a risk prediction model for a composite adverse pregnancy outcome was made with prespecified predicting factors.

RESULTS:
Among the pregnant women aged 40 years or older, 10.82% experienced one or more of the selected adverse pregnancy outcomes compared with 5.46% of pregnant women aged 20–34 years (odds ratio [OR] 2.02, 99.8% CI 1.78–2.29). When pregnant women 40 years or older were compared with women aged 20–34 years, they had a higher risk of chromosomal abnormalities (3.83% vs 0.56%, OR 7.44 [CI 5.93–9.34]), miscarriage (1.68% vs 0.42%, OR 3.10 [CI 2.19–4.38]), and birth before 34 weeks of gestation (2.01% vs 1.21%, OR 1.66 [CI 1.23–2.24]), but no increased risk of congenital malformations and stillbirth. The risk prediction chart showed that advanced maternal age, use of assisted reproductive technology, nulliparous pregnancy, smoking during pregnancy, and obesity increased the absolute predictive risk of an adverse pregnancy outcome.

CONCLUSION:
Women older than 40 years have a higher risk of chromosomal abnormalities, miscarriage, and birth before 34 weeks of gestation than younger women and should be monitored accordingly. No increased risk was observed for stillbirth and other congenital malformations. Several factors increase the risk of adverse pregnancy outcomes, but advanced maternal age drives a high proportion of the total risk score.