bluuebunny/crossref_metadata_2025_split huggingface dataset:
Column Separation in a Shut-In Liquid Hydrocarbon Transmission Pipeline
Authors: Jahromi Hamed Ghasvari , Roxas Michael , Mokamati Satya 
Published: November 2018

Crude oil transportation pipelines depend on Computational Pipeline Monitoring (CPM) systems for leak detection. Accurate prediction of the volume of vapor phase in the pipeline is very challenging when crude oil goes though phase change (column separation) in the pipeline. It is also challenging to accurately predict the vapor phase volume when the pipeline is started from extended shut-in period during which thermal cooling or heating can occur depending on the season of the year. Pipeline operators rely on the accuracy of CPMs to make decisions on column separation and to avoid the masking of a leak during column separation. The column separation can happen due to heating and/or cooling during extended pipeline shut-in, or due to elevation changes or due to flow transients.
New methods of approach to address the hydraulics are necessary when dealing with a pipeline during shut-in period. Particularly a shut-in pipeline has no longitudinal motion of fluid, however phase change occurrence attempts to set the stationary fluid inside a pipe into motion and overcoming this difficulty was not available in the literature perhaps due to lack of encumberment with similar problems. This paper explains mechanism of column separation and its transients in pipelines during extended shut-in period. The results for a 90 Km long-pipeline shut-in over a 78-hour period will be presented to show the evolution of flow field and column separation (vapor phase change) prediction and hydrodynamic pressure in the whole pipeline over the shut-in period. This paper will also critically review the current approaches available in the literature to predict the column separation.
Development of Heavy Gauge X70 Helical Line Pipe
Authors: Collins L. E. , Dunnett K. , Hylton T. , Ray A. 
Published: November 2018

A decade ago, the pipeline industry was actively exploring the use of high strength steels (X80 and greater) for long distance, large diameter pipelines operating at high pressures. However in recent years the industry has adopted a more conservative approach preferring to utilize well established X70 grade pipe in heavier wall thicknesses to accommodate the demand for increased operating pressures.
In order to meet this demand, EVRAZ has undertaken a substantial upgrade of both its steelmaking and helical pipemaking facilities. The EVRAZ process is relatively unique employing electric arc furnace (EAF) steelmaking to melt scrap, coupled with Steckel mill rolling for the production of coil which is fed into helical DSAW pipe mills for the production of large diameter line pipe in lengths up to 80 feet. Prior to the upgrade production had been limited to a maximum finished wall thickness of ∼17 mm. The upgrades have included installation of vacuum de-gassing to reduce hydrogen and nitrogen levels, upgrading the caster to improve cast steel quality and allow production of thicker (250 mm) slabs, upgrades to the power trains on the mill stands to achieve greater rolling reductions, replacement of the laminar flow cooling system after rolling and installation of a downcoiler capable of coiling 25.4 mm X70 material. As well a new helical DSAW mill has been installed which is capable of producing large diameter pipe in thicknesses up to 25.4 mm.
The installation of the equipment has provided both opportunities and challenges. Specific initiatives have sought to produce X70 line pipe in thicknesses up to 25.4 mm, improve low temperature toughness and expand the range of sour service grades available. This paper will focus on alloy design and rolling strategies to achieve high strength coupled with low temperature toughness. The role of improved centerline segregation control will be examined. The use of scrap as a feedstock to the EAF process results in relatively high nitrogen contents compared to blast furnace (BOF) operations. While nitrogen can be reduced to some extent by vacuum de-gassing, rolling practices must be designed to accommodate nitrogen levels of 60 ppm. Greater slab thickness allows greater total reduction, but heat removal considerations must be addressed in optimization of rolling schedules to achieve suitable microstructures to achieve both strength and toughness. This optimization requires definition of the reductions to be accomplished during roughing (recrystallization rolling to achieve a fine uniform austenite grain size) and finishing (pancaking to produce heavily deformed austenite) and specification of cooling rates and coiling temperatures subsequent to rolling to obtain suitable transformation microstructures. The successful process development will be discussed.
CSA Z663: Land Use Planning in the Vicinity of Pipelines
Authors: Plant Ed , Capper Sue 
Published: November 2018

There are few standards or regulations to help stakeholders consider land use and development in the vicinity of existing pipeline systems. Land use planning that considers the existence of pipeline systems can support the planning for and provision of emergency services and pipeline integrity. This approach can also promote public safety and awareness through consistent and collaborative stakeholder engagement early in the land use planning process.
In 2016, a CSA workshop was held with a variety of stakeholders impacted by land use planning around pipeline systems. The workshop identified that there was a need for consistency across the jurisdictions in the form of a national standard.
The main goal of the new CSA Z663 standard is to provide guidance and best practices for land use planning and development. It also addresses roles, responsibilities and engagement of all stakeholders to help establish a consistent approach to land use planning.
A review of CSA Z663 will illustrate how this document provides information, guidance and tools that are inclusive to all stakeholders. This paper will also highlight the history and key drivers behind the new CSA Z663 standard and provide an overview of the current scope and content. Finally, the paper will describe future considerations and additions to the standard.
Attributes of Modern Linepipes and Their Implications on Girth Weld Strain Capacity
Authors: Wang Yong-Yi , Rapp Steve , Horsley David , Warman David , Gianetto Jim 
Published: November 2018

There has been a number of unexpected girth weld failures in newly constructed pipelines. Girth weld failures have also been observed in pre-service hydrostatic testing. Post-incident investigations indicated that the pipes met the requirements of industry standards, such as API 5L. The welds were qualified per accepted industry standards, such as API 1104. The field girth welding was performed, inspected, and accepted per industry standards, such as API 1104. Some of the traditional causes of girth weld failures, such as hydrogen cracks and high-low misalignment, were not a factor in these incidents.
This paper starts with a review of the recent girth weld incidents. A few key features of a failed weld and their implications are examined. The characteristics of the recent failures is summarized, and the major contributing factors known to date are given.
Some of the options to prevent future failures include (1) changes to the tensile properties of the pipes and enhanced hardenability, (2) welding options aimed at increasing the weld strength and minimizing heat-affected zone (HAZ) softening, and (3) reduction of stresses on girth welds. This paper focuses on the first two options.
The trends of chemical composition and tensile properties of linepipe are reviewed. The potential contribution of these trends to the girth weld incidents is examined. Possible changes to the linepipe properties and necessary updates in the testing and qualification requirements of the linepipes are provided.
Welding options beneficial to enhanced girth weld strain capacity are discussed. Possible revisions to welding procedure qualification requirements, aimed at achieving a minimum level of strain tolerance/capacity, are proposed. The application of previously developed tools in estimating the propensity of HAZ softening is reviewed.
Secular trends in the prevalence of female genital mutilation/cutting among girls: a systematic analysis
Authors: Kandala Ngianga-Bakwin , Ezejimofor Martinsixtus C , Uthman Olalekan A , Komba Paul 
Published: November 2018

BackgroundCurrent evidence on the decline in the prevalence of female genital mutilation or cutting (FGM/C) has been lacking worldwide. This study analyses the prevalence estimates and secular trends in FGM/C over sustained periods (ie, 1990–2017). Its aim is to provide analytical evidence on the changing prevalence of FGM/C over time among girls aged 0–14 years and examine geographical variations in low-income and middle-income countries.MethodsAnalysis on the shift in prevalence of FGM/C was undertaken using the Demographic Health Survey (DHS) and Multiple Indicator Cluster Survey (MICS) data sets from Africa and Middle East. A random-effects model was used to derive overall prevalence estimates. Using Poisson regression models, we conducted time trends analyses on the FGM/C prevalence estimates between 1990 and 2017.FindingsWe included 90 DHS and MICS data sets for 208 195 children (0–14 years) from 29 countries spread across Africa and two countries in Western Asia. The prevalence of FGM/C among children varied greatly between countries and regions and also within countries over the survey periods. The percentage decline in the prevalence of FGM/C among children aged 0–14 years old was highest in East Africa, followed by North and West Africa. The prevalence decreased from 71.4% in 1995 to 8.0% in 2016 in East Africa. In North Africa, the prevalence decreased from 57.7% in 1990 to 14.1% in 2015. In West Africa, the prevalence decreased from 73.6% in 1996 to 25.4% in 2017. The results of the trend analysis showed a significant shift downwards in the prevalence of FGM/C among children aged 0–14 years in such regions and subregions of East Africa, North Africa and West Africa. East Africa has experienced a much faster decrease in the prevalence of the practice (trend=−7.3%, 95% CI −7.5% to −7.1%) per year from 1995 to 2014. By contrast, the decline in prevalence has been much slower in North Africa (trend=−4.4%, 95% CI −4.5% to −4.3%) and West Africa (trend=−3.0%, 95% CI −3.1% to −2.9%).ConclusionThe prevalence of FGM/C among children aged 0–14 years varied greatly between countries and regions and also within countries over the survey periods. There is evidence of huge and significant decline in the prevalence of FGM/C among children across countries and regions. There is a need to sustain comprehensive intervention efforts and further targeted efforts in countries and regions still showing high prevalence of FGM/C among children, where the practice is still pervasive.
Disability–free survival after coronary artery bypass grafting in women and men with heart failure
Authors: Sun Louise Y , Tu Jack V , Lee Douglas S , Beanlands Rob S , Ruel Marc , Austin Peter C , Eddeen Anan Bader , Liu Peter P 
Published: November 2018

ObjectiveHeart failure (HF) impairs survival post coronary artery bypass grafting (CABG), but little is known about the postoperative quality of life (QoL) in patients with HF. We derived a patient-centred QoL surrogate and assessed the impact of different HF subtypes on this surrogate in the year post-CABG.MethodsWe surveyed 3112 cardiovascular patients to derive a patient-centred disability outcome and studied this outcome in a population-based cohort. We defined preserved ejection fraction as ≥50% and reduced ejection fraction as <50%. The primary outcome was disability, defined according to compiled patient-derived values. The secondary outcomes consisted of each individual component of disability, and death. The incidence of disability was calculated using cumulative incidence functions, with death as a competing risk. We identified predictors of disability using cause-specific hazard models.ResultsPatient-derived disability outcome consisted of stroke, nursing home admission and recurrent hospitalisations. When applied to 40 083 CABG patients (20.6% women), the incidence of disability was 5.4% while the incidence of death was 3.7% in the year post-CABG. Female sex was associated with an adjusted HR of 1.25 (95% CI 1.13 to 1.37) for disability. Women with HF with preserved ejection fraction had an adjusted HR of 1.73 (95% CI 1.52 to 1.98) for disability.ConclusionsDisability was a more frequent complication than death in the year post-CABG. Women experienced higher burden of disability than men, and female sex and the presence of HF were important disability risk factors. Efforts should be dedicated to disability risk prediction to enable patient-centred operative decision-making and to developing sex-specific treatment strategies to improve outcomes.
Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis
Authors: Yan Xiang , Zhang Xiaoshan , Wang Li , Zhang Ran , Pu Xingxiang , Wu Shuhong , Li Lei , Tong Pan , Wang Jing , Meng Qing H. , Jensen Vanessa B. , Girard Luc , Minna John D. , Roth Jack A. , Swisher Stephen G. , Heymach John V. , Fang Bingliang 
Published: November 2018

Abstract

Glutathione (GSH)/GSH reductase (GSR) and thioredoxin/thioredoxin reductase (TXNRD) are two major compensating thiol-dependent antioxidant pathways that maintain protein dithiol/disulfide balance. We hypothesized that functional deficiency in one of these systems would render cells dependent on compensation by the other system for survival, providing a mechanism-based synthetic lethality approach for treatment of cancers. The human GSR gene is located on chromosome 8p12, a region frequently lost in human cancers. GSR deletion was detected in about 6% of lung adenocarcinomas in The Cancer Genome Atlas database. To test whether loss of GSR sensitizes cancer cells to TXNRD inhibition, we knocked out or knocked down the GSR gene in human lung cancer cells and evaluated their response to the TXNRD inhibitor auranofin. GSR deficiency sensitized lung cancer cells to this agent. Analysis of a panel of 129 non–small cell lung cancer (NSCLC) cell lines revealed that auranofin sensitivity correlated with the expression levels of the GSR, glutamate-cysteine ligase catalytic subunit (GCLC), and NAD(P)H quinone dehydrogenase 1 (NQO1) genes. In NSCLC patient-derived xenografts with reduced expression of GSR and/or GCLC, growth was significantly suppressed by treatment with auranofin. Together, these results provide a proof of concept that cancers with compromised expression of enzymes required for GSH homeostasis or with chromosome 8p deletions that include the GSR gene may be targeted by a synthetic lethality strategy with inhibitors of TXNRD.

Significance:
These findings demonstrate that lung cancers with compromised expression of enzymes required for glutathione homeostasis, including reduced GSR gene expression, may be targeted by thioredoxin/thioredoxin reductase inhibitors.
Preclinical Development and First-in-Human Imaging of the Integrin αvβ6 with [18F]αvβ6-Binding Peptide in Metastatic Carcinoma
Authors: Hausner Sven H. , Bold Richard J. , Cheuy Lina Y. , Chew Helen K. , Daly Megan E. , Davis Ryan A. , Foster Cameron C. , Kim Edward J. , Sutcliffe Julie L. 
Published: November 2018

AbstractPurpose:The study was undertaken to develop and evaluate the potential of an integrin αvβ6-binding peptide (αvβ6-BP) for noninvasive imaging of a diverse range of malignancies with PET.Experimental Design:The peptide αvβ6-BP was prepared on solid phase and radiolabeled with 4-[18F]fluorobenzoic acid. In vitro testing included ELISA, serum stability, and cell binding studies using paired αvβ6-expressing and αvβ6-null cell lines. In vivo evaluation (PET/CT, biodistribution, and autoradiography) was performed in a mouse model bearing the same paired αvβ6-expressing and αvβ6-null cell xenografts. A first-in-human PET/CT imaging study was performed in patients with metastatic lung, colon, breast, or pancreatic cancer.Results:[18F]αvβ6-BP displayed excellent affinity and selectivity for the integrin αvβ6 in vitro [IC50(αvβ6) = 1.2 nmol/L vs IC50(αvβ3) &gt;10 μmol/L] in addition to rapid target-specific cell binding and internalization (72.5% ± 0.9% binding and 52.5% ± 1.8%, respectively). Favorable tumor affinity and selectivity were retained in the mouse model and excretion of unbound [18F]αvβ6-BP was rapid, primarily via the kidneys. In patients, [18F]αvβ6-BP was well tolerated without noticeable adverse side effects. PET images showed significant uptake of [18F]αvβ6-BP in both the primary lesion and metastases, including metastasis to brain, bone, liver, and lung.Conclusions:The clinical impact of [18F]αvβ6-BP PET imaging demonstrated in this first-in-human study is immediate for a broad spectrum of malignancies.
Necuparanib, A Multitargeting Heparan Sulfate Mimetic, Targets Tumor and Stromal Compartments in Pancreatic Cancer
Authors: MacDonald Amanda , Priess Michelle , Curran Jennifer , Guess Jamey , Farutin Victor , Oosterom Ilse , Chu Chia Lin , Cochran Edward , Zhang Lynn , Getchell Kristen , Lolkema Martijn , Schultes Birgit C. , Krause Silva 
Published: November 2018

Abstract
Pancreatic cancer has an abysmal 5-year survival rate of 8%, making it a deadly disease with a need for novel therapies. Here we describe a multitargeting heparin-based mimetic, necuparanib, and its antitumor activity in both in vitro and in vivo models of pancreatic cancer. Necuparanib reduced tumor cell proliferation and invasion in a three-dimensional (3D) culture model; in vivo, it extended survival and reduced metastasis. Furthermore, proteomic analysis demonstrated that necuparanib altered the expression levels of multiple proteins involved in cancer-driving pathways including organ development, angiogenesis, proliferation, genomic stability, cellular energetics, and invasion and metastasis. One protein family known to be involved in invasion and metastasis and altered by necuparanib treatment was the matrix metalloprotease (MMP) family. Necuparanib reduced metalloproteinase 1 (MMP1) and increased tissue inhibitor of metalloproteinase 3 (TIMP3) protein levels and was found to increase RNA expression of TIMP3. MMP enzymatic activity was also found to be reduced in the 3D model. Finally, we confirmed necuparanib's in vivo activity by analyzing plasma samples of patients enrolled in a phase I/II study in patients with metastatic pancreatic cancer; treatment with necuparanib plus standard of care significantly increased TIMP3 plasma protein levels. Together, these results demonstrate necuparanib acts as a broad multitargeting therapeutic with in vitro and in vivo anti-invasive and antimetastatic activity.
Combining DNA Vaccine and AIM2 in H1 Nanoparticles Exert Anti-Renal Carcinoma Effects via Enhancing Tumor-Specific Multi-functional CD8+ T-cell Responses
Authors: Chai Dafei , Shan Hongjian , Wang Gang , Zhang Qing , Li Huizhong , Fang Lin , Song Jingyuan , Liu Nianli , Zhang Qian , Yao Hong , Zheng Junnian 
Published: November 2018

Abstract
Renal carcinoma presents a rapid progression in patients with high metastasis with no effective therapeutic strategy. In this study, we designed a folate-grafted PEI600-CyD (H1) nanoparticle-mediated DNA vaccine containing an adjuvant of absent in melanoma 2 (AIM2) and a tumor-specific antigen of carbonic anhydrase IX (CAIX) for renal carcinoma therapy. Mice bearing subcutaneous human CAIX (hCAIX)-Renca tumor were intramuscularly immunized with H1-pAIM2/pCAIX, H1-pCAIX, H1-pAIM2, or Mock vaccine, respectively. The tumor growth of hCAIX-Renca was significantly inhibited in H1-pAIM2/pCAIX vaccine group compared with the control group. The vaccine activated CAIX-specific CD8+ T-cell proliferation and CTL responses, and enhanced the induction of multi-functional CD8+ T cells (expressing TNF-α, IL-2, and IFN-γ). CD8+ T-cell depletion resulted in the loss of anti-tumor activity of H1-pAIM2/pCAIX vaccine, suggesting that the efficacy of the vaccine was dependent on CD8+ T-cell responses. Lung metastasis of renal carcinoma was also suppressed by H1-pAIM2/pCAIX vaccine treatment accompanied with the increased percentages of CAIX-specific multi-functional CD8+ T cells in the spleen, tumor, and bronchoalveolar lavage as compared with H1-pCAIX vaccine. Similarly, the vaccine enhanced CAIX-specific CD8+ T-cell proliferation and CTL responses. Therefore, these results indicated that H1-pAIM2/pCAIX vaccine exhibits the therapeutic efficacy of anti-renal carcinoma by enhancing tumor-specific multi-functional CD8+ T-cell responses. This vaccine strategy could be a potential and promising approach for the therapy of primary solid or metastasis tumors.
PARP Inhibition Induces Enrichment of DNA Repair–Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells
Authors: Bellio Chiara , DiGloria Celeste , Foster Rosemary , James Kaitlyn , Konstantinopoulos Panagiotis A. , Growdon Whitfield B. , Rueda Bo R. 
Published: November 2018

Abstract

PARP inhibitors (PARPi) are FDA-approved monotherapy agents for the treatment of recurrent ovarian cancer in patients with and without a BRCA mutation. Despite promising response rates, not all patients derive benefit, and the majority develop resistance. PARPi treatment in vitro and in vivo induced an enrichment of CD133+ and CD117+ ovarian cancer stem cells (CSC). This effect was not affected by BRCA mutation status. In the CSC fractions, PARPi induced cell-cycle arrest in G2–M with a consequent accumulation of γH2AX, RAD51, and uniquely DMC1 foci. DNA damage and repair monitoring assays demonstrated that CSCs display more efficient DNA repair due, in part, to activation of embryonic repair mechanisms which involved the RAD51 homologue, DMC1 recombinase. Preserved and induced homologous repair (HR) could be a mechanism of an inherent resistance of CSCs to the synthetic lethality of PARPi that likely promotes disease recurrence.

Implications:
Treatment with PARPi fails to significantly affect ovarian cancer CSC populations, likely contributing to recurrent disease. Ovarian cancer CSCs stabilize genomic integrity after PARPi treatment, due to a more efficient inherent DNA repair capacity. PARPi-induced DMC1 recombinase and HR proficiency provide CSCs the opportunity to repair DNA damage more efficiently.
Visual Overview: http://mcr.aacrjournals.org/content/molcanres/17/2/431/F1.large.jpg.