bluuebunny/crossref_metadata_2025_split huggingface dataset:
A National Framework for Children's Services: AECA's View
Authors: Vaughan Graeme , Cahir Pam 
Published: June 2019

Council of Australian Governments (COAG) proposed, in its discussion paper released in November 1995, that it develop a national framework for children's services in Australia. This is part of its review of intergovernmental responsibilities for the delivery of children's services. The review consists of two steps, the first being intergovernmental agreement on a national framework, and the second, bilateral agreements between the Commonwealth and each State and Territory to implement the national framework. The Australian Early Childhood Association, Inc. (AECA) has prepared a submission which sets out its views on the objectives, outcomes, and features of a national framework for children's services. The Association strongly believes that the interests of children should be the paramount consideration in developing the national framework for a children's services system.
Immune Checkpoint Inhibitor Outcomes for Patients With Non–Small-Cell Lung Cancer Receiving Baseline Corticosteroids for Palliative Versus Nonpalliative Indications
Authors: Ricciuti Biagio , Dahlberg Suzanne E. , Adeni Anika , Sholl Lynette M. , Nishino Mizuki , Awad Mark M. 
Published: June 2019

PURPOSE Baseline use of corticosteroids is associated with poor outcomes in patients with non–small-cell lung cancer (NSCLC) treated with programmed cell death-1 axis inhibition. To approach the question of causation versus correlation for this association, we examined outcomes in patients treated with immunotherapy depending on whether corticosteroids were administered for cancer-related palliative reasons or cancer-unrelated indications. PATIENTS AND METHODS Clinical outcomes in patients with NSCLC treated with immunotherapy who received ≥ 10 mg prednisone were compared with outcomes in patients who received 0 to < 10 mg of prednisone. RESULTS Of 650 patients, the 93 patients (14.3%) who received ≥ 10 mg of prednisone at the time of immunotherapy initiation had shorter median progression-free survival (mPFS) and median overall survival (mOS) times than patients who received 0 to < 10 mg of prednisone (mPFS, 2.0 v 3.4 months, respectively; P = .01; mOS, 4.9 v 11.2 months, respectively; P < .001). When analyzed by reason for corticosteroid administration, mPFS and mOS were significantly shorter only among patients who received ≥ 10 mg prednisone for palliative indications compared with patients who received ≥ 10 mg prednisone for cancer-unrelated reasons and with patients receiving 0 to < 10 mg of prednisone (mPFS, 1.4 v 4.6 v 3.4 months, respectively; log-rank P < .001 across the three groups; mOS, 2.2 v 10.7 v 11.2 months, respectively; log-rank P < .001 across the three groups). There was no significant difference in mPFS or mOS in patients receiving ≥ 10 mg of prednisone for cancer-unrelated indications compared with patients receiving 0 to < 10 mg of prednisone. CONCLUSION Although patients with NSCLC treated with ≥ 10 mg of prednisone at the time of immunotherapy initiation have worse outcomes than patients who received 0 to < 10 mg of prednisone, this difference seems to be driven by a poor-prognosis subgroup of patients who receive corticosteroids for palliative indications.
Standardization of Inpatient CPR Status Discussions and Documentation Within the Division of Hematology-Oncology at UPMC Shadyside: Results From PDSA Cycles 1 and 2
Authors: Garcia Christine A. , Bhatnagar Mamta , Rodenbach Rachel , Chu Edward , Marks Stanley , Graham-Pardus Abigail , Kriner Jamie , Winfield Melissa , Minnier Christopher , Leahy Janet , Hanchett Sharon , Baird Emily , Arnold Robert M. , Levenson Joshua E. 
Published: June 2019

PURPOSE: In December 2016, 49% of patients admitted to inpatient oncology services at University of Pittsburgh Medical Center Shadyside Hospital had cardiopulmonary resuscitation (CPR) status discussion documentation before discharge. The aim of this project was to improve the rate of CPR status conversations. METHODS: During Plan-Do-Study-Act (PDSA) cycle 1, a stakeholder workgroup was formed in January 2017 by oncology faculty, fellows, nurses, advance practice providers (APPs), medicine housestaff, and palliative care faculty. All oncology clinicians and inpatient team members were reminded weekly to discuss and document CPR status preferences. APPs received training on efficient and effective CPR status assessment from palliative care faculty. Oncology leadership received monthly e-mail updates of CPR status documentation rates and endorsed CPR status best practice guidelines. For PDSA cycle 2, patient charts without CPR status documentation in March 2018 were reviewed, and themes were shared with oncology leadership and reviewed with APPs. RESULTS: After PDSA cycle 1, CPR status assessment rates increased from 49% to greater than 80%. In 2017, more than 1,500 more CPR status discussions were documented than in 2016. The percentage of patients discharged with “comfort measures only” or “do not resuscitate” orders increased from 14.2% (95% CI, 9.5% to 19.0%) to 19.8% (95% CI, 15.6% to 24.0%). For PDSA cycle 2, charts of 60 patients without CPR assessment were reviewed. Of these, 52% were admitted overnight by nocturnists and 48% by daytime APPs. Fifty-five percent of patients (n = 33 of 60) had metastatic disease. CPR status was documented on previous admissions for 53% of patients (n = 31 of 60) in the past 12 months. Fifteen percent (n = 11 of 60) were admitted for scheduled inpatient chemotherapy. CONCLUSION: A multipronged approach significantly increased CPR status assessments. More patients transitioned to comfort measures only or do not resuscitate when their preferences were clearly assessed and documented.
Route of Insulin Does Not Influence 25-Hydroxyvitamin D Concentrations in Type 1 Diabetes: A Brief Report
Authors: van Dijk Peter R , Logtenberg Susan J J , Waanders Femke , Groenier Klaas H , van Goor Harry , Kleefstra Nanne , Bilo Henk J G 
Published: June 2019

Abstract
The increased prevalence of vitamin D [25(OH)D] deficiency in type 1 diabetes mellitus (T1DM) may be related to low insulin levels in the hepatic portal venous system. In this prospective matched-control study, we demonstrate that long-term intraperitoneal insulin does not influence 25(OH)D concentrations in patients with T1DM as compared with subcutaneous insulin administration.
Prospective Association of Serum Opioid Levels and Clinical Outcomes in Patients With Cancer Pain Treated With Intrathecal Opioid Therapy
Authors: Brogan Shane E. , Sindt Jill E. , Jackman Carina M. , White Julia , Wilding Victoria , Okifuji Akiko 
Published: June 2019

BACKGROUND:
Opioids remain the mainstay of cancer pain management but are associated with systemic toxicity. In refractory cancer pain, intrathecal therapy (ITT) is associated with improved pain control, reduced systemic side effects, and improved survival. It has been assumed that ITT decreases systemic serum opioid levels and their associated toxicity, but there are limited data to support this assumption. This study hypothesizes that serum opioid levels decrease with ITT. Secondary objectives include comparative measures of pain, bowel function, and other cancer-related symptoms.

METHODS:
Fifty-one cancer patients undergoing ITT for cancer pain were recruited in a prospective observational study. Daily oral morphine equivalency (OME) dose, serum opioid levels, Brief Pain Inventory (BPI), MD Anderson Symptom Inventory (MDASI), and a constipation questionnaire were obtained at the time of implant, and 4 and 8 weeks postoperatively.

RESULTS:
Average baseline daily OME was 375 mg (median, 240; interquartile range, 150–405; range, 0–3160), mean serum morphine concentration was 53.7 ng/mL (n = 17), and mean oxycodone concentration was 73.7 ng/mL (n = 20). At 4 weeks, 87.5% of patients had discontinued non-IT opioids, and 53% had undetectable (<2 ng/mL) serum opioid concentrations. At 8 weeks, 92% remained off all non-IT opioids and 59% had undetectable serum opioid levels. IT morphine doses >4.2 mg/d were invariably associated with detectable serum levels; with doses <4.2 mg, morphine was undetectable in 80% of subjects. IT hydromorphone doses >6.8 mg/d were detectable in the serum. Using linear mixed model analyses, there were statistically significant decreases in the mean “worst pain,” “average pain,” and MD Anderson symptom severity and interference scores at 4 and 8 weeks. This change was independent of serum opioid levels; when analyzed separately, there was no difference in the pain scores of subjects with detectable serum opioid levels compared to those with undetectable levels at 4 and 8 weeks. Constipation ranked as “quite a bit” or “very much” decreased from 58.7% to 19.2% of subjects at week 4 (P < .001) and to 37.5% at 8 weeks (P = .23). A very low complication rate was observed.

CONCLUSIONS:
ITT for cancer pain was associated with a marked reduction in serum opioid concentrations, with the majority of patients having undetectable serum levels. Reducing serum opioid concentrations in cancer patients may have implications with respect to restoring bowel function, improving fatigue, and promoting the integrity of antitumor immune function and warrants further study.
Solvent Effect on the Fluorescence Properties of Two Biologically Active Thiophene Carboxamido Molecules
Authors: Nagaraja D , Geethanjali H S , Patil N R , Sanningannavar F M , Kusanur R A , Melavanki R M 
Published: June 2019

The absorption and fluorescence spectra of two thiophene carboxamido molecules namely 2–( - trimethoxy phenyl) imino–3–N–ethylcarboxamido–4, 5, tetramethylene thiophene (X) and 2-( -N, N-dimethylaminophenyl) imino-3-(N- methylphenyl carboxamido)-4, 5, tetramethylene thiophene (Y) have been recorded at room temperature. The ground (mg) and excited (me) state dipole moments are estimated from Lippert, Bakhshiev, Kawski-Chamma-Viallet equations by using the variation of Stokes shift with microscopic solvent dielectric constant (e) and refractive index (n). The excited dipole moments were also estimated by using the variation of Stokes shift with microscopic empirical solvent polarity parameter and the values are compared. It was estimated that dipole moments of the excited state were higher than those of the ground state of both the molecules. Further, the change in dipole moment (Dm) were calculated both from solvatochromic shift method and on the basis of microscopic empirical solvent polarity parameter .
NaBr/98% H2SO4: An Efficient Reagent for the Regioselective Monobromination of Least Reactive Alkanes and Cycloalkanes
Authors: Afzal Pasha Mohamad , Nagashree Shrivatsa 
Published: June 2019

An efficient, simple and regioselective monobromination of least reactive acyclic and cyclic alkanes by sodium bromide/ 98% H2SO4 is reported. The yields are high and the reactions go to completion within 15–35 min. at 40–65 ºC.
Contra Harmonic Mean Labelling of Graphs
Authors: G Narasimhan R Sampathkumar 
Published: June 2019

A graph labelling is an assignment of integers to the vertices or edges or both subject to certain conditions. A Graph G(V, E) with p vertices and q edges is called a Contra Harmonic mean graph if it is possible to label all the vertices x ∈ V with distinct labels f(x) from {1, 2, 3, 4, …., p } in such a way that each edge e = uv is labelled with
f uv = f(u) 2 + f(v) 2
f u +f(v)
or f uv = f(u) 2 + f(v) 2
f u +f(v)
are distinct.
On the Tachocline Zone Location in the Sun, the Luminosity Transport time scale, the Rotational Inertia and their Time Variation in Standard Solar Evolution Models
Authors: Anandaram Mandyam N 
Published: June 2019

Studies with GONG Standard Solar Evolution Models sampling the evolution of the sun from its ZAMS stage show the following. The location of the tachocline zone is nearly fixed as it is not affected by shell burning although it co-moves with the expansion of the sun up to the present age of 4.6 Gyr. The luminosity transport time scale of the sun is entirely dominated by photon diffusion and during the evolution has decreased from over 204000 years to 187000 years. The rotational inertia of the sun shows a small gradual increase from
Characterization and Electrical Conductivity of Electron Beam Irradiated Metal Phthalocyanine Complexes
Authors: H S Jayanna Ashok R Lamani 
Published: June 2019

Variation of DC electrical conductivity with temperature from 273-473 K of electron beam irradiated Tetra-nitro zinc, and Cu-Pcs, were carried out. It shows semiconductor behavior and resistivity varies from 0.043×10 5 Ω -cm to 64.61×10 5 Ω -cm for all complexes. Variation of conductivity with temperature shows two straight lines of different slopes the first line (LT), resembles the α– phase, (Ea 1 ) = 0.226 eV while the second line at 362 K resembles the β - phase (Ea 2 ) = 0.460 eV (for Cu- Pcs). The β -phase shows higher activation energy than the α -phase, and the X-ray diffraction studies reveal that the crystals are monoclinic. The conductivity is explained on the basis of Davis and Mott model. The conduction mechanism at lower temperature is explained in terms of hoping through a band of localized states and at higher temperatures in terms of thermal excitation of carriers to the band edge.
On Equality and Strong Equality of Domination Number and Independent Domination Number in Graphs
Authors: Femlin Pious , Mayamma Joseph 
Published: June 2019

In this paper we explore graphs having same domination number and independent domination number . Such graphs are denoted as ( , )-graphs. Several families of ( , )-graphs have been constructed. The realization problem for graphs with = = a for any given positive integer a has been solved. Furthermore, properties of graphs in which every -set is a -set has been investigated.
UV emission line studies of NGC-low redshift Seyfert Galaxies, LINERS and HII regions
Authors: P Vedavathi , Doddamani Vijayakumar H 
Published: June 2019

Active galaxies as a special class of galaxies are characterized by very strong and broad emission lines. The strong emission lines such as Lyα, NV, Si IV, C IV, and Mg II observed in the UV spectra of Seyfert galaxies and quasars can be used to probe the physical conditions of the gas in the BLR regions surrounding the central accretion discs of these most luminous and exotic objects. In the standard model of broad line emission regions for active galaxies it is assumed that the broad permitted lines are emitted by the photo-ionization of a large number of spherically distributed optically thick clouds which are in Keplerian motion surrounding a central continuum source. However, issues related to variability time-scales, delays in the light curves and BLR sizes etc., remain unexplained consistent with observations. In this paper, a study of emission line properties 9 objects satisfying good SNR (> 5.0) out of 98 NGC (catalogued) IUE observed low redshift active galaxies (z ≤ 0.017) is presented. The International Ultraviolet Explorer (IUE) satellite launched in 1978 by NASA has made low redshift UV spectroscopic observations of many different kinds of UV sources including active galaxies till 1996 and the flux calibrated spectral data of almost all observations have been hosted in NED-IUE database. In the present studies, IUE spectral data of a complete sample of NGC-catalogued active galaxies has been undertaken to understand the emission line properties of low luminosity and low z active galaxies. We find that the emission lines such as Lyα, N V, Si IV, O III], C III], C IV, and Mg II are observed as strong and broad lines in the spectra of only 9 objects owing to the criterion of S/N ≥ 5.0 adopted for the spectral analysis. The Lyα has not been found to be a strong line unlike in high z Seyfert galaxies and quasars observed by IUE satellite. C IV and Mg II lines are observed to be stronger lines in all the nine objects consistent with their usual presence in the remaining (~ 400) active galaxies observed by the IUE satellite. These observations are indicative of different physical and geometrical conditions in the BLR regions surrounding the central accretion disk compared to the intermediate and high redshift Seyfert galaxies and quasars.
Hexagonal Difference Prime Labeling of Some Path Graphs
Authors: Sunoj B S , Varkey Mathew T K 
Published: June 2019

Hexagonal difference prime labeling of vertices of a graph is the labeling of the vertices of the graph with hexagonal numbers and the edges with absolute value of the difference of the labels of the incident vertices. The greatest common incidence number (gcin) of a vertex of degree greater than one is defined as the greatest common divisor of the labels of the incident edges. If the gcin of each vertex of degree greater than one is 1, then the graph admits hexagonal difference prime labeling. Here we identify some path related graphs for hexagonal difference prime labeling.
L(t, 1)-Colouring of Cycles
Authors: Pandey Priyanka , Kureethara Joseph Varghese 
Published: June 2019

For a given finite set T including zero, an L(t, 1)-colouring of a graph G is an assignment of non-negative integers to the vertices of G such that the difference between the colours of adjacent vertices must not belong to the set T and the colours of vertices that are at distance two must be distinct. For a graph G, the L(t, 1)-span of G is the minimum of the highest colour used to colour the vertices of a graph out of all the possible L(t, 1)-colourings. We study the L(t, 1)-span of cycles with respect to specific sets.
Differential chemoreactome analysis of synergistic combinations of tolperisone and nonsteroidal anti-inflammatory drugs
Authors: Torshin I. Yu. , Gromova O. A. , Stakhovskaya L. V. , Semenov V. A. , Gromov A. N. 
Published: June 2019

The concurrent use of muscle relaxants and nonsteroidal anti-inflammatory drugs (NSAIDs) is a promising treatment for painful muscle hypertonia and convulsive states.Objective: to identify the most effective and safe synergist combinations of tolperisone and NSAIDs.Material and methods. A differential chemoreactome analysis was employed to evaluate the effects of the muscle relaxant tolperisone and five NSAIDs (dexketoprofen, etoricoxib, meloxicam, naproxen, and diclofenac). The biological activities of the molecules under study were assessed in five sections: 1) inhibition of the proteins of prostaglandin and leukotriene metabolism; 2) inhibition of the effects of the transcription factor nuclear factor kappa, tumor necrosis factor-, and other anti-inflammatory mechanisms; 3) inhibition of excessive blood coagulation and platelet aggregation; 4) vasodynamic effects; 5) antitumor properties on cell lines in culture.Results and discussion. Based on the differences in the pharmacological activity profiles of tolperisone and NSAIDs under study, the investigators identified the most promising synergistic combinations, in which both active ingredients complemented each other as effectively and safely as possible. The obtained estimates of the degree of synergism of various combinations of tolperisone and NSAIDs hold that the most promising antithrombotic, and antitumor effects.Conclusion. The results of this study will help adequately choose combinations of muscle relaxants and NSAIDs in patients with muscle hypertonia, which will be able to improve the efficiency and safety of treatment.
“Do we really need this class?”: Former K-12 Teachers Transitioning to Teaching as University Faculty
Authors: Jimenez-Silva Margarita , Kulinna Pamela Hodges , Cirell Anna Montana , Balmaseda Matt 
Published: June 2019

Background: It was the purpose of this study to investigate graduate students’ perceptions and the processes related to learning to teach at university/college level using socio-cultural theory and ecological systems. . Methods: A survey based on Bronfenbrenner’s Ecological Systems (1977) and a Knowledge –Confidence-Usefulness instrument (Barton-Arwood, Morrow, Lane & Jolivette, 2005) was administered to graduate students four times (N=10). Four interviews, class observations and document analyses were also conducted. Descriptive statistics were calculated for the survey data and interview data were analyzed via constant comparison. Results: Findings showed high internal consistency reliability of the items (>.93) and that graduate students’ perceptions of their experiences to prepare to teach at the university level were quite positive. Themes were related to being confident, having the potential to be effective at the post-secondary level, and a mismatch between experiences and expectations. Using the emergent process model of Chi and colleagues (2012), overall perceived dynamics (macro level), the individuated university agents/students within the socialization process (micro level) and the social subgroups into which the agent/student network (meso level) support an ecological form of faculty development. Conclusions: Results provide support for an ecological systems model as well as insights into faculty teaching development.
“There is no escaping it”: Graduate Student Conceptions of Environment and their Implications for Learning Motivation and Public Health Curricula
Authors: Cheesman Katherine L , Ahonen Emily Q 
Published: June 2019

This manuscript stems from observations the authors made while teaching an environmental health course, which is part of a Master of Public Health (MPH) degree. Observations of student attitudes and patterns in course feedback prompted questions about how to pique interest in the course. Since research on motivation has shown that adult learners build new knowledge from what they believe they already know, we first sought to better understand this basis for learning. On the first day of class, students were administered an assignment prompting them to "define environment" in their own words; data were analyzed for content. Results characterize student conceptions of environment as being (1) beyond human influence and (2) individually-focused. The implications of these "alternative conceptions" of environmental public health for educators seeking to motivate adult learners are discussed. Restructuring coursework to reflect Transformative Learning Theory (TLT) is identified as a potential solution to student amotivation.
Identification Author of Source Code by Machine Learning Methods
Authors: Kurtukova Anna , Romanov Alexander 
Published: June 2019

The paper is devoted to the analysis of the problem of determining the source code author , which is of interest to researchers in the field of information security, computer forensics, assessment of the quality of the educational process, protection of intellectual property.
The paper presents a detailed analysis of modern solutions to the problem. The authors suggest two new identification techniques based on machine learning algorithms: support vector machine, fast correlation filter and informative features; the technique based on hybrid convolutional recurrent neural network.
The experimental database includes samples of source codes written in Java, C ++, Python, PHP, JavaScript, C, C # and Ruby. The data was obtained using a web service for hosting IT-projects – Github. The total number of source codes exceeds 150 thousand samples. The average length of each of them is 850 characters. The case size is 542 authors.
The experiments were conducted with source codes written in the most popular programming languages. Accuracy of the developed techniques for different numbers of authors was assessed using 10-fold cross-validation. An additional series of experiments was conducted with the number of authors from 2 to 50 for the most popular Java programming language. The graphs of the relationship between identification accuracy and case size are plotted. The analysis of result showed that the method based on hybrid neural network gives 97% accuracy, and it’s at the present time the best-known result. The technique based on the support vector machine made it possible to achieve 96% accuracy. The difference between the results of the hybrid neural network and the support vector machine was approximately 5%.