bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negotiating Imitation: Examining the Interactions of Consultants and Clients to Understand Institutionalization as Translation
Authors: Gill Michael J. , McGivern Gerry , Sturdy Andrew , Pereira Sandra , Gill David J. , Dopson Sue 
Published: June 2019

AbstractOrganizational scholars increasingly view institutionalization as a process through which actors adapt or translate seemingly successful practices in a field to create variations that are specific to their own organization. Yet little is known about how outsiders who seek to diffuse ‘best practice’ affect translation. We examined interactions between management consultants and their clients in two different consulting projects, which focused on embedding the practice of ‘lean’ in one and the practice of a quality improvement framework in the other. Our findings provide insights into the processes of translation through which promoters and adopters iterate at different stages to reach a compromise, illuminating how the evolution of an imported practice signals the outcome of a negotiation. Furthermore, we demonstrate that management practices are not translated in isolation but enveloped by peripheral practices that are adopted by association. We highlight how the peripheral practice of benchmarking, in both cases, was rarely contested or negotiated and thus proved more resistant to translation. Our analysis allows us to unpack the agency inherent withintranslation‐as‐negotiationand integrate research on diffusion and translation.
Properties and Applications of Morinda citrifolia (Noni): A Review
Authors: Almeida Édipo S. , de Oliveira Débora , Hotza Dachamir 
Published: June 2019

AbstractMorinda citrifolia commonly known as noni is a perennial plant originating in Southeast Asia, consumed over 2000 years. Due to its versatility of adaptation and use of the structures of the plant for different therapeutic purposes, noni attracted the attention of researchers from the pharmaceutical and food industry. Chemical and nutritional analyzes already performed in M. citrifolia reveal the existence of more than 200 phytochemical substances with bioactive properties such as acids, alcohols, phenols, saccharides, anthraquinones, carotenoids, esters, triterpenoids, flavonoids, glycosides, lactones, iridoids, ketones, lactones, lignans, nucleosides, triterpenides, sterols, and aromatic compounds. The high nutritional value of M. citrifolia may induce therapeutic effects, including antimicrobial and antioxidant properties. The main industrial products from this plant are beverages (juice drinks), powders (from dried fruits), oil (from seeds), and leaf powders. Biological and phytotherapeutic applications of M. citrifolia are promising, but more extensive studies are still required. Thus, this review aims to gather updated and comprehensive information on Morinda citrifolia, discussing its traditional use, biochemical, phytotherapics, and toxicological properties, as well as the recent advances in the processing and standardization of products derived from noni fruit.
Mortality among people with regular or problematic use of amphetamines: a systematic review and meta‐analysis
Authors: Stockings Emily , Tran Lucy Thi , Santo Thomas , Peacock Amy , Larney Sarah , Santomauro Damian , Farrell Michael , Degenhardt Louisa 
Published: June 2019

AbstractBackground and aimsAmphetamines are the second most commonly used class of illicit drugs. We aimed to produce pooled estimates of mortality risks among people with regular or dependent use of amphetamines, with a focus upon all‐cause mortality as well as specific causes of death.DesignSystematic review and meta‐analysis of cohorts of people with problematic use or dependence on amphetamines with data on all‐cause or cause‐specific mortality.Setting and participantsOf 4240 papers, 30 were eligible, reporting on 25 cohorts that measured all‐cause mortality, drug poisoning, suicide, accidental injuries, homicide and cardiovascular mortality. Cohorts (n = 35–74 139) were in North America, several Nordic countries and Asia Pacific.MeasurementTitles/abstracts were independently screened by one reviewer and excluded those reviewed by a second reviewer. Full‐text screening was by two reviewers with discrepancies resolved via a third reviewer. We extracted data on crude mortality rates (CMR) per 100 person‐years (py), standardized mortality ratios (SMRs). We imputed SMRs where possible if not reported by study authors. We also calculated mortality relative risks. Data were pooled using random‐effects models; potential reasons for heterogeneity were explored using subgroup analyses and meta‐regressions.FindingsTwenty‐three cohorts contributed data for the pooled all‐cause CMR: 1.14 per 100 py [95% confidence interval (CI) = 0.92–1.42]. Pooled cause‐specific mortality rates were: drug poisoning, 0.14 per 100 py (95% CI = 0.06–0.34); cardiovascular disease, 0.13 per 100 py (95% CI = 0.06–0.29); suicide, 0.20 per 100 py (95% CI = 0.07–0.55); accidental injury, 0.20 per 100 py (95% CI = 0.08–0.47) and homicide, 0.03 per 100 py (95% CI = 0.02–0.06). There was substantial heterogeneity for all pooled CMR estimates except homicide. The pooled all‐cause SMR was 6.83 (95% CI = 5.27–8.84). Pooled cause‐specific SMRS were: poisoning, 24.70 (95% CI = 16.67, 36.58); homicide, 11.90 (95% CI = 7.82–18.12); suicide, 12.20 (95% CI = 4.89–30.47); cardiovascular disease, 5.12 (95% CI = 3.74–7.00) and accidental injury, 5.12 (95% CI = 2.88–9.08).ConclusionsPeople with regular or dependent amphetamine use are at elevated risk of a range of causes of mortality compared with people without regular or dependent amphetamine use.
Temperature‐dependent development of the double‐spined spruce bark beetle Ips duplicatus (Sahlberg, 1836) (Coleoptera; Curculionidae)
Authors: Davídková Markéta , Doležal Petr 
Published: June 2019

AbstractDevelopment of the double‐spined spruce bark beetle Ips duplicatus (Sahlberg, 1836) was investigated using the sandwich method under long‐day conditions (LD 18 : 6 h) at 10 constant temperatures: 7, 10, 12, 15, 20, 25, 30, 33, 35 and 39 °C. The method proved unsuitable at lower temperatures (7–12 °C), where high mortality occurred.
At higher temperatures, development from egg to eclosion of adults shortened from 39.0 days at 15 °C to 10.3 days at 30 °C. Temperatures over 33 °C were lethal to all eggs, larvae and pupae. The developmental rate increased linearly at temperatures between 15 and 25 °C.
Stage‐specific parameters, such as upper and lower developmental thresholds and optimum temperature for development, were determined by linear and nonlinear (Logan‐Lactin) models. Lower developmental thresholds obtained from nonlinear regression were calculated to be 9 °C (eggs), 6.1 °C (larvae), 6.9 °C (pupae) and 6.3 °C (development from eggs to pupae). Upper developmental thresholds for all stages oscillated around 39 °C and optimal temperatures oscillated around 30 °C.
The rapid development of I. duplicatus at 15 and 30 °C [10 and 4 days faster than Ips typographus (L.), respectively] may explain its recent outbreak dynamics and low effectivity of preventive control measures
A splicing mutation in PHKG1 decreased its expression in skeletal muscle and caused PSE meat in Duroc × Luchuan crossbred pigs
Authors: Liu Y. , Liu Y. , Ma T. , Long H. , Niu L. , Zhang X. , Lei Y. , Wang L. , Chen Y. , Wang Q. , Zheng Z. , Xu Xuewen 
Published: June 2019

SummaryIn recent years, Luchuan pigs in southern China have been used to produce high‐quality meat by crossbreeding them with Duroc boars; however, PSE (pale, soft and exudative) meat was frequently reported in the crossbred pigs, and the underlying reason remains unknown. We excluded the possibility of the well‐known causative mutations in RYR1 and PRKAG3 but identified the existence of an unfavorable allele of a splicing mutation (g.8283C>A) in PHKG1 in two Duroc boars and three Duroc × Luchuan crossbred pigs with PSE meat. An association analysis with 425 Duroc × Luchuan crossbred pigs revealed that the polymorphism of the splicing site of PHKG1 has significant association with the ultimate meat pH value (P = 0.035) and color score (P = 0.004). In addition, a strong cis‐eQTL (expression QTL) signal for the expression of PHKG1 was identified in 189 Duroc × Luchuan crossbred pigs, and the splicing mutation was proven to be significantly associated with the expression of PHKG1 (P = 4.01e‐11). Furthermore, RNA‐sequencing data analysis confirmed that 131 CC homozygotes had only one transcript (T1), with FPKM (fragments per kilobase of transcript per million) of 35.40 ± 7.28, and 58 CA heterozygotes had two types of transcripts (T1 and T2), with FPKM of 19.63 ± 5.11 and 9.20 ± 2.39 respectively. Based on the association and eQTL analysis results, we concluded that PSE meat in Duroc × Luchuan crossbred pigs is caused by the splicing mutation in PHKG1. Our findings further support the effect of the causative mutation in PHKG1 on meat quality. The GEO accession number for the data is GSE124315.
Prospective two‐year study of clinical outcomes following epithelium‐off pulsed versus continuous accelerated corneal crosslinking for keratoconus
Authors: Ziaei Mohammed , Gokul Akilesh , Vellara Hans , Meyer Jay , Patel Dipika , McGhee Charles N. J. 
Published: June 2019

AbstractImportanceKeratoconus is a debilitating condition with a disproportionately high impact on health resources and vision‐specific quality of life.BackgroundThis study aimed to compare 2‐year outcomes of epithelium‐off pulsed (p‐ACXL) and epithelium‐off continuous (c‐ACXL) accelerated corneal crosslinking in progressive keratoconus.DesignProspective, interventional case series.ParticipantsEighty eyes of 80 patients were included.MethodsThe visual, refractive and tomographic results of the two crosslinking protocols were compared.Main Outcome MeasuresUncorrected distance visual acuity, corrected distance visual acuity (CDVA), manifest refraction spherical equivalent (MRSE) and maximum keratometry (KMAX) on corneal tomography assessment.ResultsThe mean patient age was 22.51 ± 6.12 years (SD) and 22.08 ± 5.72 years in the p‐ACXL and c‐ACXL groups, respectively. The mean CDVA significantly improved from 0.30 ± 0.16 logMAR at baseline to 0.23 ± 0.17 logMAR at 24 months (P = .04) in the p‐ACXL group and from 0.36 ± 0.22 logMAR to 0.26 ± 0.27 logMAR (P = .02) in the c‐ACXL group. The mean induced change in MRSE (+1.79 ± 2.30 D vs +0.27 ± 3.19 D, P = .04) and KMAX (−1.75 ± 1.80 D vs −0.39 ± 1.95 D, P = .04) were superior in the c‐ACXL group compared to the p‐ACXL group at 24 months. No complications were encountered.Conclusions and RelevanceIn this prospective study, both p‐ACXL and c‐ACXL treatments were safe methods to halt the progression of keratoconus within a follow‐up period of 24 months. c‐ACXL appeared to offer superior refractive and tomographic outcomes when compared to p‐ACXL but this did not translate into better visual outcomes.
No significant association of type 2 diabetes‐related genetic risk scores with glycated haemoglobin levels after initiating metformin or sulphonylurea derivatives
Authors: Martono Doti P. , Heerspink Hiddo J.L. , Hak Eelko , Denig Petra , Wilffert Bob 
Published: June 2019

AbstractAimTo explore the added value of diabetes‐related genetic risk scores (GRSs) to readily available clinical variables in the prediction of glycated haemoglobin (HbA1c) levels after initiation of glucose‐regulating drugs.Materials and methodsWe conducted a cohort study in people with type 2 diabetes (T2DM) from the Groningen Initiative to Analyse Type 2 Diabetes Treatment (GIANTT) database who initiated metformin (MET) or sulphonylurea derivatives (SUs) and for whom blood samples were genotyped. The primary outcome was HbA1c level at 6 months, adjusted for baseline HbA1c. GRSs were based on single nucleotide polymorphisms linked to insulin sensitivity, β‐cell activity, and T2DM risk in general. Associations were analysed using multiple linear regression to assess whether adding the GRSs increased the explained variance in a prediction model that included age, gender, diabetes duration and cardio‐metabolic biomarkers.ResultsWe included 282 patients initiating MET and 89 patients initiating SUs. In the MET prediction model, diabetes duration of >3 months when starting MET was associated with 2.7‐mmol/mol higher HbA1c level. For SUs, no significant clinical predictors were identified. Addition of the GRS linked to insulin sensitivity (for MET), β‐cell activity (for SUs) and T2DM risk (for both) to the models did not improve the explained variance significantly (22% without vs. 22% with GRS) for the MET and (14% without vs. 14% with GRS) for the SUs model, respectively.ConclusionThis study did not indicate a significant effect of GRS related to T2DM in general or to the drugs' mechanism of action for prediction of inter‐individual HbA1c variability in the short term after initiation of MET or SU therapy.
A review of the abundance, behaviour and detection of clostridial pathogens in agricultural soils
Authors: Palmer Joseph S. , Hough Rupert L. , West Helen M. , Avery Lisa M. 
Published: June 2019

AbstractThe soil is a reservoir for various clostridial pathogens, with agricultural soils representing a major source of contamination for overlying crops and grazing livestock. Understanding the prevalence and behaviour of pathogens in these soils is fundamental to ascertaining and mitigating the risk of disease from agroecosystems. This article reviews research pertaining to the overall distribution and abundance of clostridial pathogens in the soil while identifying possible environmental and soil factors influencing their behaviour. Large‐scale soil screens have identified pathogens across the globe, although some Clostridium botulinum toxinotypes are more prevalent in certain geographic regions. Faecal inputs and organic waste amendments to the soil can elevate the levels of enteric clostridial pathogens in the soil and the subsequent disease risk, as highlighted by case–control studies. The ability of Clostridia to sporulate results in their long‐term persistence post‐introduction, increasing the time period for disease transmission. Regularly or permanently saturated soils may also enhance survival, or potentially facilitate the regrowth of some indigenous or introduced Clostridia. This is supported by the high prevalence of Clostridia in paddy soils, greater detection of pathogens in flooded soils, and the higher onset of some clostridial diseases in regions with poorly drained soils. Future research should elucidate soil types and environmental conditions which can enhance pathogen survival/regrowth. The adoption of molecular and sequencing technologies for future diagnostics can facilitate more sensitive detection and a higher resolution of pathogen typing, allowing a better understanding of pathogen population dynamics in farm soils and disease epidemiology.Highlights

Understanding the behaviour of soil‐borne clostridial pathogens is key for disease management.
Soil, environmental and management factors affecting pathogen survival/introduction are discussed.
Soil waterlogging and application of organic soil amendments may increase the number of soil pathogens.
More pathogen surveillance and standardisation of diagnostics to better understand behaviour is needed.
COPPADIS‐2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015): an ongoing global Parkinson's disease project about disease progression with more than 1000 subjects included. Results from the baseline evaluation
Authors: Santos García D. , Jesús S. , Aguilar M. , Planellas L. L. , García Caldentey J. , Caballol N. , Legarda I. , Hernández Vara J. , Cabo I. , López Manzanares L. , González Aramburu I. , Ávila Rivera M. A. , Catalán M. J. , López Díaz L. , Puente V. , García Moreno J. M. , Borrué C. , Solano Vila B. , Álvarez Sauco M. , Vela L. , Escalante S. , Cubo E. , Carrillo Padilla F. , Martínez Castrillo J. C. , Sánchez Alonso P. , Alonso Losada M. G. , López Ariztegui N. , Gastón I. , Kulisevsky J. , Menéndez González M. , Seijo M. , Rúiz Martínez J. , Valero C. , Kurtis M. , de Fábregues‐Boixar O. , González Ardura J. , Prieto Jurczynska C. , Martinez‐Martin P. , Mir P. ,   on behalf of the COPPADIS Study Group
Published: June 2019

Background and purposeIn Parkinson's disease (PD), the course of the disorder is highly variable between patients. Well‐designed, prospective studies for identifying PD progression biomarkers are necessary. Our aim was to show the results of baseline evaluations of an ongoing global PD project, COPPADIS‐2015 (Cohort of Patients with PArkinson's DIsease in Spain, 2015).MethodsThis was an observational, descriptive, nationwide study (Spain). The recruitment period ended in October 2017. Baseline evaluation included more than 15 validated scales and complementary studies in a subgroup of participants.ResultsIn total, 1174 subjects from 35 centres were considered valid for baseline analysis: 694 patients (62.6 ± 8.9 years old, 60.3% males), 273 caregivers (58.5 ± 11.9 years old, 31.8% males) and 207 controls (61 ± 8.3 years old, 49.5% males). The mean disease duration was 5.5 ± 4.4 years. Hoehn and Yahr stage was 1 or 2 in 90.7% of the patients whilst 33.9% and 18.1% of them presented motor fluctuations and dyskinesias, respectively. The mean Non‐Motor Symptoms Scale total score was 45.4 ± 38.1, and 30.4% of the patients presented cognitive impairment, 16.1% major depression, 12.7% impulse control disorder, 7.2% compulsive behaviour, 57.2% pain and 13.2% falls. Compared to the control group, PD patients presented a significantly higher burden of non‐motor symptoms and a worse quality of life. More than 300 subjects conducted complementary studies (serum biomarkers, genetic and neuroimaging).ConclusionsParkinson's disease is a complex disorder and different non‐motor symptoms are frequently present and are more prevalent than in controls. In real clinical practice it is important to ask for them.
Phenotypic selection under two contrasting environments in wild sunflower and its crop–wild hybrid
Authors: Presotto Alejandro , Hernández Fernando , Mercer Kristin L. 
Published: June 2019

AbstractHybridization is a common phenomenon in plants and can lead to the introgression of alleles from one population into another, generate new hybrid lineages, or cause species extinction. The environmental conditions and the genetic background of the participating populations may influence these outcomes since they can affect the fitness of hybrids, thereby increasing or decreasing the chances of introgression. Thus, it is important to understand the context‐dependent prospects for introgression of alleles into diverse populations and under multiple ecological environments. Crop–wild hybridization presents an opportunity to explore these dynamics in agroecosystems. To this end, we used diverse wild and hybrid sunflowers from across the northern United States as a basis for evaluating variation in morphological traits and assessing context‐dependent selection. These crop–wild hybrids and their wild counterparts were grown under agricultural conditions in the field with and without wheat competition. Interactions between origin and cross type affected expression of early functional traits, while interactions between competition and cross type acted on reproductive traits. A smattering of early and reproductive traits was affected by interactions between cross type and competition that varied by origin (i.e., 3‐way interactions). Seven functional traits, especially number of branches and tertiary head diameter, underwent net and direct directional selection, while six out of these seven traits appear to also be experiencing nonlinear selection dynamics. In general, wild‐like traits were favored under both sets of conditions, while, under wheat competition, some crop‐like traits related to fast growth and primary head diameter became important. These data reaffirm the hypothesis that stressful conditions establish a scenario more suitable for crop introgression and clarify that nonlinear selection dynamics may play a role in this process.
Developing the Shanghai online games industry: A multi‐scalar institutional perspective
Authors: Gong Huiwen , Hassink Robert 
Published: June 2019

AbstractIn recent decades, while place‐based policies and local development have attracted the interest of institutional economic geography, the issue of features of certain industries and how they are shaping and shaped by institutions at multiple spatial scales, has not been taken up sufficiently. This paper, based on a local creative industry—the Shanghai online games industry, which is an essential part of the new media sector, takes issue with it. It explores two aspects, namely how multi‐scalar institutions relate and influence the development of the online games industry in Shanghai and how local firms and entrepreneurs affect local and national institutions. It shows that the three aspects that are related to media sector in general and games industry in particular (i.e., cultural influence, technological significance, and economic value) matter much as they have resulted in diverse industry‐relevant policies and regulations devised by local and national states. Moreover, local firms and entrepreneurs with different capacities and characteristics also differ much in influencing the design of the industry‐specific institutions in the face of institutional voids.
What do we know about the health and health care of people with intellectual disabilities from minority ethnic groups in the United Kingdom? A systematic review
Authors: Robertson Janet , Raghavan Raghu , Emerson Eric , Baines Susannah , Hatton Chris 
Published: June 2019

AbstractBackgroundPeople with from minority ethnic communities face inequalities in health and health care. This systematic review considers the question of what we know about the health and health care of children and adults with intellectual disabilities from ethnic minority communities in the UK.MethodStudies published from 1990 to 2018 were identified via electronic literature databases, email requests and cross‐citations. Studies were reviewed narratively in relation to identified themes.ResultsTwenty‐three studies were identified, most commonly focusing on South Asian communities. Very little information was identified on physical health or physical health care, with the identified evidence tending to focus on mental health care, access to specialist intellectual disability services, and inpatient services.ConclusionLittle is known about the health status of people with intellectual disabilities from minority ethnic groups in the UK. It is clear that they may experience barriers to accessing specialist intellectual disability services and other forms of health care.