bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustained safe and effective anticoagulation using Edoxaban via percutaneous endoscopic gastrostomy
Authors: Galli Mattia , D'Amario Domenico , Andreotti Felicita , Porto Italo , Vergallo Rocco , Sabatelli Mario , Lancellotti Stefano , Meleo Emiliana , De Cristofaro Raimondo , Crea Filippo 
Published: June 2019

AbstractExtensive data support the safety of direct oral anticoagulants compared with vitamin K antagonists in patients with non‐valvular atrial fibrillation, leading to a significantly increase in the use of these compounds in clinical practice. However, there is no compelling evidence supporting the use of direct oral anticoagulant in individuals who are intubated or have a percutaneous endoscopic gastrostomy (PEG): patients with several co‐morbidities are underrepresented in clinical trials, so the best long‐term strategy for anticoagulation is difficult to ascertain. The aim of the present report was to evaluate the safety and efficacy of edoxaban administered via PEG in a patient with heart failure and a history of atrial fibrillation affected by amyotrophic lateral sclerosis (ALS). A 71‐year‐old man with atrial fibrillation, advanced ALS, type II diabetes mellitus, and hypertension presented to the emergency department with dyspnoea and tachycardia. Because vitamin K antagonist and rivaroxaban 15 mg were dropped because of difficult international normalized ratio control (time in therapeutic range <30%) and severe haematuria, respectively, edoxaban 30 mg (crushed pill) daily was administered based on the patient's weight of 58 kg. Mean edoxaban plasma concentration–time profiles were measured, as anti‐Xa activity, 2 h before and at 2, 6, and 22 h after drug administration and then compared with the pharmacokinetic profile of edoxaban 30 mg in healthy subjects. An additional testing of steady‐state peak plasma concentration of edoxaban after 10 days and a 30 day follow‐up were evaluated. The values of the pharmacokinetic parameters, analysed with a non‐compartmental analysis by PKSolver module, showed that Cmax and AUC0→t were only slightly higher than those observed in healthy subjects, while the half‐life and observed clearance were significantly longer and lower, respectively, than in normal subjects. Steady‐state peak plasma concentration of edoxaban was very similar to the levels reported in healthy subjects, and neither relevant bleeding nor thromboembolic event was reported at a 30 day follow‐up. These results support safe and effective anticoagulation with edoxaban 30 mg but suggest caution with the use of full dose of edoxaban (60 mg daily) in this kind of patients. We report, for the first time, a safe and effective anticoagulation based on the administration of edoxaban 30 mg daily through PEG in a patient with advanced ALS, acute respiratory, and heart failure, presenting with Takotsubo syndrome and atrial fibrillation.
MitraClip improves cardiopulmonary exercise test in patients with systolic heart failure and functional mitral regurgitation
Authors: Benito‐González Tomás , Estévez‐Loureiro Rodrigo , Garrote‐Coloma Carmen , Iglesias Garriz Ignacio , Gualis Javier , Álvarez‐Roy Laura , Rodriguez‐Santamarta Miguel , Pérez de Prado Armando , Fernández‐Vázquez Felipe 
Published: June 2019

AbstractAimsThe aim of this study is to evaluate changes in cardiopulmonary exercise test (CPET) after percutaneous mitral valve repair (PMVR) with MitraClip in patients with heart failure with reduced ejection fraction who are potentially candidates for heart transplantation or destination left ventricular assist device.Methods and resultsProspective registry of all consecutive patients with heart failure with reduced ejection fraction and functional mitral regurgitation (MR) underwent elective PMVR between October 2015 and March 2018 in our institution. Patients with preserved or mid‐range left ventricular ejection fraction (>40%), advanced age (>75 years old), or severe co‐morbidities (end‐stage organ damage) were not included. Treadmill exercise testing with respiratory gas exchange analysis was carried out in 11 patients (male, 72.7%; median age, 67 years old) within the month prior to the procedure and at 6 month follow‐up. PMVR was successfully performed in all patients. At 6 month follow‐up, PMVR was associated with an improvement in New York Heart Association functional class (P = 0.021) and a reduction in MR severity (P = 0.013) and N‐terminal pro‐brain natriuretic peptide levels (2805 [1878–5022] vs. 1485 [654–3032] pg/mL; P = 0.012). All patients completed pre‐procedural and post‐procedural CPET, and all the studies showed a respiratory exchange ratio ≥1 and were consistent with sufficient exercise effort. Compared with pre‐procedural CPET, patients showed a significant increase in exercise time (295 [110–335] vs. 405 [261–540] s; P = 0.047), VO2 (9.8 [9.1–13.4] vs. 13.5 [12.1–16.8] mL/kg/min; P = 0.033), ventilatory anaerobic threshold (510 [430–950] vs. 850 [670–1070] mL/kg/min; P = 0.033), peak O2 pulse (7.2 [4.3–8.6] vs. 8.3 [6.2–11.8] mL/beat; P = 0.033), and workload (5 [3–6] vs. 6 [5–8] metabolic equivalents; P = 0.049).ConclusionsPercutaneous mitral valve repair with MitraClip was associated with an enhancement in cardiopulmonary performance in patients with systolic heart failure and secondary MR.
Assessment of municipal solid waste for valorization into biofuels
Authors: Thompson Vicki S. , Ray Allison E. , Hoover Amber , Emerson Rachel , Hartley Damon , Lacey Jeffrey A. , Yancey Neal , Thompson David N. 
Published: June 2019

AbstractAlmost 36 million tons of paper and yard trimmings are not currently being recycled or composted annually and likely end up in landfills. One approach to valorize these resources would be for biofuels production. Nonrecyclable municipal solid waste (MSW) paper and yard trimmings were assessed for their suitability as feedstocks to produce biofuels from sugars. Both materials met the cost target of less than $85.51/ton ($2016) with MSW paper ranging from $36.40 to $62.18/dry ton and grass clippings from $25.64 to $45.86/dry ton. MSW paper exceeded the carbohydrate requirement of 59% while grass clippings had significantly lower amounts of carbohydrates (30%). However, both types of MSW had ash contents significantly above the required 5% total ash with paper at 22% ash and grass clippings at 16%. While neither waste material was individually found to be suitable for biofuels production based on compositional requirements, it was determined that blending either waste with corn stover would produce materials that met carbohydrate, ash, and cost targets. The higher carbohydrate and lower ash stover compensated for the lower carbohydrates and high ash of the waste materials, while the lower cost waste materials offset the higher cost of corn stover.
Gaussian mixture–based equivalent linearization method (GM‐ELM) for fragility analysis of structures under nonstationary excitations
Authors: Yi Sang‐ri , Wang Ziqi , Song Junho 
Published: June 2019

SummaryGaussian mixture–based equivalent linearization method (GM‐ELM) is a recently developed stochastic dynamic analysis approach which approximates the random response of a nonlinear structure by collective responses of equivalent linear oscillators. The Gaussian mixture model is employed to achieve an equivalence in terms of the probability density function (PDF) through the superposition of the response PDFs of the equivalent linear system. This new concept of linearization helps achieve a high level of estimation accuracy for nonlinear responses, but has revealed some limitations: (1) dependency of the equivalent linear systems on ground motion intensity and (2) requirements for stationary condition. To overcome these technical challenges and promote applications of GM‐ELM to earthquake engineering practice, an efficient GM‐ELM‐based fragility analysis method is proposed for nonstationary excitations. To this end, this paper develops the concept of universal equivalent linear system that can estimate the stochastic responses for a range of seismic intensities through an intensity‐augmented version of GM‐ELM. Moreover, the GM‐ELM framework is extended to identify equivalent linear oscillators that could capture the temporal average behavior of nonstationary responses. The proposed extensions generalize expressions and philosophies of the existing response combination formulations of GM‐ELM to facilitate efficient fragility analysis for nonstationary excitations. The proposed methods are demonstrated by numerical examples using realistic ground motions, including design code–conforming nonstationary ground motions.
Nonlinear analysis of masonry structures using fiber‐section line elements
Authors: Peruch Matteo , Spacone Enrico , Camata Guido 
Published: June 2019

SummaryFor seismic analysis of unreinforced masonry (URM) buildings characterized by a box‐like behavior, a widely accepted model is based on the equivalent frame idealization of walls. The equivalent frame model uses 1D elements to represent the vertical piers and horizontal spandrels which are connected by rigid nodes. The mechanical characterization of the elements is one of the crucial aspects to predict reasonably the building seismic behavior. Through the comparison with pseudo‐static and dynamic experimental tests performed on two‐story full‐scale buildings, this paper validates the frame modeling in the OpenSees framework, which includes a fiber‐section force‐based beam element for the axial‐flexural behavior, coupled with a cyclic shear‐deformation phenomenological law.
Eradication of Hepatitis C Virus Is Associated With Reduction in Hematologic Malignancies: Major Differences Between Interferon and Direct‐Acting Antivirals
Authors: Ioannou George N. , Green Pamela K. , Berry Kristin , Graf Solomon A. 
Published: June 2019

It is unclear whether eradication of hepatitis C virus (HCV) leads to a reduction in the risk of hematologic malignancies. We aimed to determine the impact of sustained virologic response (SVR) induced by either direct‐acting antivirals (DAAs) or interferon (IFN) on the risk of hematologic malignancies. We identified 69,581 patients who initiated antiviral treatment in the Veterans Affairs national health care system from January 1, 1999, to December 31, 2015, including 40,410 (58%) IFN‐only regimens, 4,546 (6.5%) DAA + IFN regimens, and 24,625 (35%) DAA‐only regimens. We retrospectively followed patients to identify incident cases of hematologic malignancies or monoclonal gammopathy of unknown significance (MGUS), a premalignant precursor of multiple myeloma. Among patients treated with IFN, SVR was significantly associated with a reduction in the risk of lymphoma (adjusted hazard ratio [AHR], 0.70; 95% confidence interval [CI], 0.51‐0.97), multiple myeloma (AHR, 0.40; 95% CI, 0.20‐0.77), MGUS (AHR, 0.65; 95% CI, 0.42‐0.99), or all hematologic malignancies and MGUS combined (AHR, 0.67; 95% CI, 0.53‐0.84) over a mean follow‐up of 10.6 years. In contrast, among patients treated with DAA, SVR was not associated with the risk of lymphoma, multiple myeloma, MGUS, or all hematologic malignancies and MGUS combined (AHR, 1.08; 95% CI, 0.66‐1.78) during a mean follow‐up of 2.9 years. Neither IFN‐induced SVR nor DAA‐induced SVR was associated with risk of colon cancer or prostate cancer, which were chosen a priori as comparison/control malignancies. Conclusion: We describe novel strong associations between IFN‐induced SVR and lymphoma, multiple myeloma, MGUS, and all hematologic malignancies combined. Surprisingly, these associations were not observed with DAA‐induced SVR.
Molecular docking explores heightened immunogenicity and structural dynamics of acetaldehyde human immunoglobulin G adduct
Authors: Waris Sana , Habib Safia , Khan Shifa , Kausar Tasneem , Naeem Shahid M. , Siddiqui Shahid A. , Moinuddin  , Ali Asif 
Published: June 2019

AbstractAcetaldehyde is a metabolite of ethanol, an important constituent of tobacco pyrolysis and the aldehydic product of lipid peroxidation. Acetaldehyde induced toxicity is mainly due to its binding to cellular macromolecules resulting in the formation of stable adducts accompanied by oxidative stress. The aim of this study was to characterize structural and immunological alterations in human immunoglobulin G (IgG) modified with acetaldehyde in the presence of sodium borohydride, a reducing agent. The IgG modifications were studied by various physicochemical techniques such as fluorescence and CD spectroscopy, free amino group estimation, 2,2‐azobis 2‐amidinopropane (AAPH) induced red blood cell hemolysis as well as transmission electron microscopy. Molecular docking was also employed to predict the preferential binding of acetaldehyde to IgG. The immunogenicity of native and acetaldehyde‐modified IgG was investigated by immunizing female New Zealand white rabbits using native and modified IgG as antigens. Binding specificity and cross reactivity of rabbit antibodies was screened by competitive inhibition ELISA and band shift assays. The modification of human IgG with acetaldehyde results in quenching of the fluorescence of tyrosine residues, decrease in free amino group content, a change in the antioxidant property as well as formation of cross‐linked structures in human IgG. Molecular docking reveals strong binding of IgG to acetaldehyde. Moreover, acetaldehyde modified IgG induced high titer antibodies (>1:12800) in the experimental animals. The antibodies exhibited high specificity in competitive binding assay toward acetaldehyde modified human IgG. The results indicate that acetaldehyde induces alterations in secondary and tertiary structure of IgG molecule that leads to formation of neo‐epitopes on IgG that enhances its immunogenicity.
LINC00261 suppresses human colon cancer progression via sponging miR‐324‐3p and inactivating the Wnt/β‐catenin pathway
Authors: Yan Dongsheng , Liu Weidong , Liu Yeliu , Luo Man 
Published: June 2019

AbstractGrowing evidence indicates long noncoding RNAs (lncRNAs) are significant regulators in the progression of various malignant tumors including colon cancer. Dysregulation of lncRNA LINC00261 has been identified in many cancers. Investigations on LINC00261 function have revealed that LINC00261 could act as a crucial tumor suppressor in various cancers. But, the biological involvement of LINC00261 in colon cancer is still barely known. Here, we found LINC00261 was reduced in colon cancer cells. Meanwhile, overexpressed LINC00261 repressed colon cancer cell viability and proliferation capacity. In addition, colony cancer cell colony formation was inhibited and apoptosis was enhanced by upregulation of LINC00261. Also, colon cancer cell migration and invasion both were restrained by LINC00261. miR‐324‐3p can exert important functions in several carcinomas, but its role in colon cancer is uninvestigated. In the current study, miR‐324‐3p was examined and miR‐324‐3p was greatly increased in colon cancer cells. Moreover, the association between miR‐324‐3p and LINC00261 was confirmed via performing RNA immunoprecipitation and RNA‐pull‐down experiments. In cancer biology, aberrant modulation of the Wnt signaling pathway remains a prevalent theme. Overexpression of LINC00261 obviously impaired colon cancer progression via inactivating the Wnt pathway. Furthermore, in the xenograft model assay, an increase of LINC00261 could suppress colon tumor growth via sponging miR‐324‐3p and inactivating the Wnt pathway. Overall, our results showed that LINC00261 repressed colon cancer progression via regulating miR‐324‐3p and the Wnt pathway. LINC00261 could be established as a novel therapeutic target for colon cancer.
Population Pharmacokinetics of Pregabalin Extended‐Release in Healthy Volunteers and Patients With Postherpetic Neuralgia, Fibromyalgia, and Partial‐Onset Seizures
Authors: Chew Marci , Ma Guangli , Xie Rujia , Bockbrader Howard , Chapel Sunny , Marshall Scott 
Published: June 2019

AbstractA population pharmacokinetic (PK) model was developed to characterize the properties of pregabalin extended‐release (ER) in healthy volunteers and was subsequently applied to patient data from efficacy/safety studies investigating pregabalin ER for postherpetic neuralgia, fibromyalgia, and partial‐onset seizures. The impact of demographic and other covariates on PK was assessed, and various dosing scenarios were simulated to inform pregabalin ER dosing/administration instructions. Phase 1 and 3 models were developed using data from 14 phase 1 studies (12 627 samples from 335 participants receiving pregabalin immediate‐release [IR] or ER) and 3 phase 3 studies (2591 samples from 1235 patients receiving pregabalin ER), respectively. Final phase 1 and 3 models adequately characterized the data. Several covariates were statistically significant, but renal function (creatinine clearance) was considered the only clinically relevant covariate. The relationship between creatinine clearance and pregabalin clearance was reasonably consistent between phase 1 and 3 models and with that reported previously with pregabalin IR data alone. Patients with moderate renal impairment who received pregabalin ER 82.5 mg once daily (QD) had similar predicted area under the plasma concentration–time curve and peak plasma concentration values as patients with normal/mild renal impairment who received 165 mg QD. Ranges in predicted PK parameters after switching from pregabalin IR administered in the morning to ER after a meal at 3, 6, or 9 pm were similar. Administration of a missed evening dose at bedtime with food or the next morning with food did not result in clinically important changes in predicted PK parameters.
Design by taking perspectives: How engineers explore problems
Authors: Murray Jaclyn K. , Studer Jaryn A. , Daly Shanna R. , McKilligan Seda , Seifert Colleen M. 
Published: June 2019

AbstractBackgroundProblem exploration includes identifying, framing, and defining design problems and bounding problem spaces. Intentional and unintentional changes in problem understanding naturally occur as designers explore design problems to create solutions. Through problem exploration, new perspectives on the problem can emerge along with new and diverse ideas for solutions. By considering multiple problem perspectives varying in scope and focus, designers position themselves to increase their understandings of the “real” problem and engage in more diverse idea generation processes leading to an increasing variety of potential solutions.Purpose/HypothesisThe purpose of this study was to investigate systematic patterns in problem exploration in the early design phases of mechanical engineers.Design/MethodThirty‐five senior undergraduate students and experienced designers with mechanical engineering backgrounds worked individually following a think‐aloud protocol. They explored problems and generated solutions for two of four randomly assigned design problems. After generating solutions, participants framed and rewrote problem statements to reflect their perspectives on the design problem their solutions addressed. Thematic analysis and a priori codes guided the identification of problem exploration patterns within and across problems.ResultsThe set of patterns in engineers' problem exploration that emerged from the analysis documents alternative strategies in exploring problems to arrive at solutions. The results provide evidence that engineering designers, working individually, apply both problem‐specific and more general strategies to explore design problems.ConclusionsOur study identified common patterns in the explorations of presented problems by individual engineering designers. The observed patterns, described as Problem Exploration Perspectives, capture alternative approaches to discovering problems and taking multiple problem perspectives during design. Learning about Problem Exploration Perspectives may be helpful in creating alternative perspectives on a design problem, potentially leading to more varied and innovative solutions. This paper concludes with an extended example illustrating the process of applying Problem Exploration Perspectives to move between problem perspectives to generate varied design outcomes.
Coupled Si and O isotope measurements of meteoritic material by laser fluorination isotope ratio mass spectrometry
Authors: Hill Patrick J. A. , Banerjee Neil R. , Ali Arshad , Jabeen Iffat , Osinski Gordon R. , Longstaffe Fred J. 
Published: June 2019

AbstractWe present a procedure for the determination of the isotopic ratios of silicon and oxygen from the same aliquot of anhydrous silicate material. The sample is placed in a bromine pentafluoride atmosphere as it is heated with a CO2 laser system releasing silicon tetrafluoride and oxygen gasses. The oxygen gas is then purified to remove other reaction by‐products through several liquid nitrogen traps before being captured onto a molecular sieve and transferred to an isotope ratio mass spectrometer. The silicon tetrafluoride gas is then purified using a supplementary line by repeatedly freezing to −196°C with liquid nitrogen and then thawing with an ethanol slurry at −110°C through a series of metal and Pyrex traps. The purified gas is then condensed into a Pyrex sample tube before it is transferred to an isotope ratio mass spectrometer for silicon isotope ratio measurements. This system has silicon yields of greater than 90% for pure quartz, olivine, and garnet standards and has a reproducibility of ±0.1‰ (2σ) for pure quartz for both oxygen and silicon isotope measurements. Meteoritic samples were also successfully analyzed to demonstrate this system's ability to measure the isotopic ratio composition of bulk powders with precision. This unique technique allows for the fluorination of planetary material without the need for wet chemistry. Though designed to analyze small aliquots of meteoritic material (1.5 to 3 mg), this approach can also be used to investigate refractory terrestrial samples where traditional fluorination is not suitable.