bluuebunny/crossref_metadata_2025_split huggingface dataset:
Losartan has no additive effect on the response to heavy-resistance exercise in human elderly skeletal muscle
Authors: Heisterberg Mette Flindt , Andersen Jesper L. , Schjerling Peter , Lund Alberte , Dalskov Simone , Jønsson Anders Overgård , Warming Nichlas , Fogelstrøm Mathilde , Kjaer Michael , Mackey Abigail L. 
Published: August 2018

Our purpose here was to investigate the potential of blocking the angiotensin II type I receptor (AT1R) on the hypertrophy response of elderly human skeletal muscle to 4 mo of heavy-resistance exercise training. Fifty-eight healthy elderly men (+65 yr) were randomized into three groups, consuming either AT1R blocker (losartan, 100 mg/day) or placebo for 4 mo. Two groups performed resistance training (RT) and were treated with either losartan or placebo, and one group did not train but was treated with losartan. Quadriceps muscle biopsies, MR scans, and strength tests were performed at baseline and after 8 and 16 wk. Biopsies were sectioned for immunohistochemistry to determine the number of satellite cells, capillaries, fiber type distribution, and fiber area. Gene expression levels of myostatin, connective tissue, and myogenic signaling pathways were determined by real-time RT-PCR. Four months of heavy-resistance training led in both training groups to expected improvements in quadriceps (∼3–4%) and vastus lateralis (∼5–6%), cross-sectional area, and type II fiber area (∼10–18%), as well as dynamic (∼13%) and isometric (∼19%) quadriceps peak force, but with absolutely no effect of losartan on these outcomes. Furthermore, no changes were seen in satellite cell number with training, and most gene targets failed to show any changes induced by training or losartan treatment. We conclude that there does not appear to be any effect of AT1R blocking in elderly men during 4 mo of resistance training. Therefore, we do not find any support for using AT1R blockers for promoting muscle adaptation to training in humans.NEW & NOTEWORTHY Animal studies have suggested that blocking angiotensin II type I receptor (AT1R) enhances muscle regeneration and prevents disuse atrophy, but studies in humans are limited. Focusing on hypertrophy, satellite cells, and gene expression, we found that AT1R blocking did not result in any greater responses with 4 mo of resistance training. These results do not support previous findings and question the value of blocking AT1R in the context of preserving aging human muscle.
Lower cutaneous microvascular reactivity in adult cancer patients receiving chemotherapy
Authors: Sutterfield S. L. , Caldwell J. T. , Post H. K. , Lovoy G. M. , Banister H. R. , Ade C. J. 
Published: August 2018

Cancer patients with a history of anticancer chemotherapy are at an increased cardiovascular disease risk compared with cancer-free populations. Therefore, we tested the hypothesis that cancer patients receiving adjuvant chemotherapy would have a lower cutaneous microvascular reactivity and lower endothelium-dependent flow-mediated dilation (FMD) of the brachial artery compared with matched cancer-free control subjects. To test this hypothesis, we performed a case control study with seven cancer patients receiving adjuvant chemotherapy and seven matched healthy reference control subjects. Red blood cell flux was measured as an index of cutaneous blood flow via laser Doppler flowmetry. Acetylcholine (ACh)-mediated vasodilation was determined by iontophoresis. Data were expressed as percent increase in cutaneous vascular conductance. Endothelium-dependent FMD of the brachial artery via ultrasonography was determined as an index of macrovessel endothelial function. Cutaneous microvascular reactivity was attenuated in cancer patients compared with control subjects [cancer: 959.9 ± 187.3%, control: 1,556.8 ± 222.2%; P = 0.03, effect size (ES) = 1.1]. Additionally, cancer patients demonstrated a significantly lower area under the curve response to ACh iontophoresis compared with healthy control subjects. Brachial artery FMD was also significantly lower in cancer patients compared with control subjects (cancer: 2.2 ± 0.6%, control: 6.6 ± 1.4%; P = 0.006, ES = 1.6), which was significantly associated with measurements of microvascular reactivity. These findings suggest that decreases in vascular reactivity can occur during cancer chemotherapy, which may have implications for the long-term risk of cardiovascular disease morbidity and mortality.NEW & NOTEWORTHY Cancer survivors treated with chemotherapy experience an increased risk of cardiovascular events, linked to both cardiac and vascular toxicity. The major finding of this study is that microvascular reactivity and macrovascular endothelium-dependent flow-mediated dilation are lower in cancer patients currently receiving adjuvant chemotherapy compared with healthy counterparts.
Phase II Trial of Alisertib in Combination with Irinotecan and Temozolomide for Patients with Relapsed or Refractory Neuroblastoma
Authors: DuBois Steven G. , Mosse Yael P. , Fox Elizabeth , Kudgus Rachel A. , Reid Joel M. , McGovern Renee , Groshen Susan , Bagatell Rochelle , Maris John M. , Twist Clare J. , Goldsmith Kelly , Granger M. Meaghan , Weiss Brian , Park Julie R. , Macy Margaret E. , Cohn Susan L. , Yanik Greg , Wagner Lars M. , Hawkins Randall , Courtier Jesse , Lai Hollie , Goodarzian Fariba , Shimada Hiroyuki , Boucher Najee , Czarnecki Scarlett , Luo Chunqiao , Tsao-Wei Denice , Matthay Katherine K. , Marachelian Araz 
Published: August 2018

AbstractPurpose:In phase I testing, alisertib tablets with irinotecan and temozolomide showed significant antitumor activity in patients with neuroblastoma. This study sought to confirm activity of this regimen; evaluate an alisertib oral solution; and evaluate biomarkers of clinical outcomes.Patients and Methods:We conducted a two-stage phase II trial of alisertib tablets (60 mg/m2/dose × 7 days), irinotecan (50 mg/m2/dose i.v. × 5 days), and temozolomide (100 mg/m2/dose orally × 5 days) in patients with relapsed or refractory neuroblastoma. The primary endpoint was best objective response. A separate cohort was treated with alisertib at 45 mg/m2 using oral solution instead of tablets. Exploratory analyses sought to identify predictors of toxicity, response, and progression-free survival (PFS) using pooled data from phase I, phase II, and oral solution cohorts.Results:Twenty and 12 eligible patients were treated in the phase II and oral solution cohorts, respectively. Hematologic toxicities were the most common adverse events. In phase II, partial responses were observed in 19 evaluable patients (21%). The estimated PFS at 1 year was 34%. In the oral solution cohort, 3 patients (25%) had first cycle dose-limiting toxicity (DLT). Alisertib oral solution at 45 mg/m2 had significantly higher median Cmax and exposure compared with tablets at 60 mg/m2. Higher alisertib trough concentration was associated with first cycle DLT, whereas MYCN amplification was associated with inferior PFS.Conclusions:This combination shows antitumor activity, particularly in patients with MYCN nonamplified tumors. Data on an alisertib oral solution expand the population able to be treated with this agent.
miR-652 Promotes Tumor Proliferation and Metastasis by Targeting RORA in Endometrial Cancer
Authors: Sun Xiaomei , Dongol Samina , Qiu Chunping , Xu Ying , Sun Chenggong , Zhang Zhiwei , Yang Xingsheng , Zhang Qing , Kong Beihua 
Published: August 2018

Abstract

Endometrial cancer is the most common gynecologic malignancy, whose incidence rate is on the rise. However, the underlying mechanisms of endometrial cancer are not very clear yet. miRNAs have been considered to be playing important roles in malignant behavior. Here, miR-652 was significantly upregulated in endometrial cancer, which correlated with shorter overall survival and earlier recurrence. Moreover, overexpression of miR-652 in endometrial cancer cells promoted proliferation, migration, and invasion in vitro and facilitated tumor growth and metastasis in vivo. In contrast, downregulation of miR-652 in endometrial cancer cells inhibited these processes both in vitro and in vivo. Mechanistically, miR-652 promotes proliferation and metastasis through directly targeting RORA. Both mRNA and protein level of RORA were negatively related with miR-652 and overexpression of RORA can rescue the promotion effect of miR-652. Further experiments indicated miR-652 overexpression can activate the Wnt/β-catenin pathway and RORA can downregulate β-catenin and function as a tumor suppressor in endometrial cancer. Collectively, these findings demonstrate that miR-652 functions as an oncomir in endometrial cancer.

Implications:
This study suggests that the miR-652 is a critical regulator of proliferation and metastasis in endometrial cancer and may serve as a therapeutic target.
Caracterização estratigráfica dos depósitos sedimentares cenozoicos da Bacia do Ribeirão Sardinha, porção sul do Quadrilátero Ferrífero (MG), e estabelecimento de background geoquímico
Authors: Santos Rayme Loureiro dos , Costa Adivane Terezinha 
Published: August 2018

Este trabalho apresenta os resultados de levantamentos sedimentológicos e geoquímicos realizados na Bacia do Ribeirão Sardinha, porção sul do Quadrilátero Ferrífero, estado de Minas Gerais, Brasil. O estudo fundamentou-se na caracterização faciológica de perfis verticais de depósitos de barrancos e terraços e em dados mineralógicos e químicos relacionados às fácies identificadas e aos sedimentos atuais do afluente principal (barras e canal). A amostragem das fácies reconhecidas e dos sedimentos atuais totalizaram 54 amostras. A mineralogia foi obtida via difração de raios X e os dados geoquímicos, através da espectrometria de emissão óptica por plasma acoplado indutivamente (inductively coupled plasma optical emission spectrometry — ICP-OES). Os dados químicos foram submetidos a análises de componentes principais (principal component analysis — PCA) e utilizados para a aplicação da técnica Tukey inner fence (TIF), que possibilitou o estabelecimento de valores de background dos seguintes elementos: Fe, Mn, Al, Ba, Cu, Zn, As, Ni, Cr e Co. Os resultados de PCA indicam uma forte relação entre o Mn e os sedimentos atuais do Ribeirão Sardinha. Outros padrões geoquímicos foram realçados pelas altas concentrações de Fe e Mn, relacionadas aos sedimentos arenosos e cascalhosos de barras e canal, e pelos elevados teores de Al e K vinculados aos sedimentos finos constituintes dos depósitos de planícies de inundação e de lagoas de cheia. Os cálculos dos valores de background mostram um valor de referência elevado para o As (32,89 mg/kg) e anomalias referentes às altas concentrações de Al, Cu, Zn, Ni e Cr, sugerindo fontes geogênicas. Por outro lado, anomalias referentes aos valores elevados de Co, Ba e Mn estão relacionadas a fontes antropogênicas.
Effects of Long- and Short-Term Atmospheric Water Cycles on the Water Balance over the Maritime Continent
Authors: Kanamori Hironari , Kumagai Tomo’omi , Fujinami Hatsuki , Hiyama Tetsuya , Yasunari Tetsuzo 
Published: August 2018

Abstract
This study investigated atmospheric water cycles over several time scales to understand the maintenance processes that control heavy precipitation over the islands of the Maritime Continent. Large island regions can be divided into land, coastal, and ocean areas based on the characteristics of both the hydrologic cycle and the diurnal variation in precipitation. Within the Maritime Continent, the major islands of Borneo and New Guinea exhibit different hydrologic cycles. Large-scale circulation variations, such as the seasonal cycle and the Madden–Julian oscillation, have a lesser effect on the hydrologic cycle over Borneo than over New Guinea because the effects depend on their shapes and locations. The impact of diurnal variations on both regional-scale circulation and water exchange between land and coastal regions is pronounced over both islands. The recycling ratio of precipitation, which can be related to stronger diurnal variation in the atmospheric water cycle that results from enhanced evapotranspiration over tropical rain forests, is higher over Borneo than over New Guinea.
Ma2/d promotes myonuclear positioning and association with the sarcoplasmic reticulum
Authors: Reuveny Adriana , Shnayder Marina , Lorber Dana , Wang Shuoshuo , Volk Talila 
Published: August 2018

ABSTRACT
The cytoplasm of striated myofibers contains a large number of membrane organelles, including sarcoplasmic reticulum (SR), T-tubules and the nuclear membrane. These organelles maintain a characteristic juxtaposition that appears to be essential for efficient inter-membranous exchange of RNA, proteins and ions. We found that the membrane-associated Muscle-specific α2/δ (Ma2/d) subunit of the Ca2+ channel complex localizes to the SR and T-tubules, and accumulates at the myonuclear surfaces. Furthermore, Ma2/d mutant larval muscles exhibit nuclear positioning defects, disruption of the nuclear-SR juxtapositioning, as well as impaired larval locomotion. Ma2/d localization at the nuclear membrane depends on the proper function of the nesprin ortholog Msp300 and the BAR domain protein Amphiphysin (Amph). Importantly, live imaging of muscle contraction in intact Drosophila larvae indicated altered distribution of Sarco/Endoplamic Reticulum Ca2+-ATPase (SERCA) around the myonuclei of Ma2/d mutant larvae. Co-immunoprecipitation analysis supports association between Ma2/d and Amph, and indirectly with Msp300. We therefore suggest that Ma2/d, in association with Msp300 and Amph, mediates interactions between the SR and the nuclear membrane.
Banking on “Mobile Money”: The Implications of Mobile Money Services on the Value Chain
Authors: Dong Yan , Chung Moonwon , Zhou Chen , Venkataraman Sriram 
Published: August 2018

Problem definition: This study examines the effects of mobile money on the value chain, that is, mobile network operators (MNOs), banks, and end users. Mobile money is an innovative technology that is bundled with related services and is designed to provide cost-efficient financial inclusion for underserved populations in the developing world. Academic/practical relevance: By studying the interaction between mobile money value chain structures and service bundle compositions, we expand our understanding on value chain revenue allocation mechanisms in developing economies. This study provides a valuable foundation for practitioners to better coordinate the value chain and facilitate sustainable growth of mobile money services. Methodology: By combining proprietary and public data, we assess the impact of launching mobile money and the potential asymmetric effects of credit payments on the performance of the value chain. We identify control groups by using propensity score matching and estimate a quasi-experimental difference-in-difference regression. Results: We find that the launch of mobile money has had a positive effect on the performance of the value chain, consisting of old, poor, and undereducated populations. However, although some bundled, complementary services, such as credit payments, benefit participating banks, they may be associated with lower MNO profits. Moreover, the effects of mobile money on the value chain remain positive and stable over time, whereas the effects of credit payments are stronger over time. Managerial Implications: Findings suggest that MNOs and banks should be encouraged to launch mobile money and expand the customer base to old, poor, and less-educated members of the population. Certain services such as credit payment may yield asymmetric benefits such that banks could consider compensation mechanisms for the MNOs. Policy makers in developing countries should encourage coordination and promote a fair distribution of benefits between the two partners to sustain the growth of mobile money services. The online appendices are available at https://doi.org/10.1287/msom.2018.0717 . This paper has been accepted for the Manufacturing & Service Operations Management Special Issue on Value Chain Innovations in Developing Economies.
KEWENANGAN SERTA OBYEK SENGKETA DI PERADILAN TATA USAHA NEGARA SETELAH ADA UU No. 30 / 2014 tentang ADMINISTRASI PEMERINTAHAN
Authors: Putrijanti Aju 
Published: August 2018

Peradilan Tata Usaha Negara memiliki kewenangan untuk memeriksa, memutus dan menyelesaikan sengketa di bidang tata usaha negara dan memeriksa obyek sengketa yaitu keputusan tata usaha negara. UU Nomor 30 Tahun 2014 tentang Administrasi Pemerintahan menambah kewenangan PTUN serta perluasan obyek sengketa. Penambahan kewenangan PTUN dan perluasan obyek sengketa harus diikuti dengan sinkronisasi perundangan di bidang peradilanAdministrative Court has an authority to examine, decide and settle the dispute in administrative field and the object is administrative decree. Act No. 30 Year 2014 of Governance Administration gives more authority and widen the object. This should followed with synchronized the law in Administrative Court
PERSPEKTIF AGAMA-AGAMA DI INDONESIA TERHADAP PLURALISME AGAMA
Authors: Utoyo Marsudi 
Published: August 2018

For Indonesia plurality is a fact. To set the required plurality of pluralism. Because, no doubt, contain the seeds of discord plurality, this required tolerance, openness, and equality. Pluralism allows for harmony in society, pluralism encourages freedom, including freedom of religion, and is a pillar of democracy. There is no true democracy without pluralism. Pluralism here means the protection of the state against the rights of its citizens to embrace the religion according to what he believes. Religious pluralism means building tolerance, we must recognizes that any religion with adherents of each have the same rights. So that must be built is feeling and mutual respect between religious communitiesBagi bangsa Indonesia pluralitas itu merupakan kenyataan. Untuk mengatur pluralitas diperlukan pluralisme. Sebab, tidak bisa dipungkiri, pluralitas mengandung bibit perpecahan, inilah diperlukan sikap toleran, keterbukaan, dan kesetaraan. Pluralisme memungkinkan terjadinya kerukunan dalam masyarakat, pluralisme mendorong kebebasan, termasuk kebebasan beragama, dan merupakan pilar demokrasi. Tidak ada demokrasi yang sejati tanpa pluralisme. Pluralisme di sini berarti perlindungan negara terhadap hak-hak warganegaranya untuk memeluk agama sesuai dengan apa yang diyakininya. Pluralisme agama berarti membangun toleransi, kita harus mengakui bahwa setiap agama dengan para pemeluknya masing-masing mempunyai hak yang sama. Maka yang harus dibangun adalah perasaan dan sikap saling menghormati antar pemeluk agama
POLA HARMONISASI BUDAYA DALAM SISTEM KOMUNIKASI HUKUM SEBAGAI USAHA PENEGAKAN HUKUM
Authors: Fitriati Fitriati 
Published: August 2018

Conflict and lawlessness often occurs in the community due to the inability to communicate the problems that occur in the middle of them and the lack of legal knowledge. The method used is qualitative research. The results showed the rule of law in a pluralistic society is still oriented to the planting of the value of local norms. Society tends to adhere to local rules that exist with diversity than comply with state law. Harmonization of pattern formation in the culture of communication systems for law enforcement can be done with a mixture of culture in a pluralistic society. Effect seen with the pattern of cultural harmonization is the use of legal communications become more effective in terms of law enforcementKonflik dan pelanggaran hukum kerap terjadi pada masyarakat dikarenakan ketidakmampuan untuk mengkomunikasikan masalah yang terjadi di tengah mereka dan kurangnya pengetahuan hukum. Metode penelitian yang digunakan adalah penelitian kualitatif. Hasil penelitian menunjukan penegakan hukum pada masyarakat pluralistik masih berorientasi pada penanaman nilai norma lokal. Masyarakat cenderung mematuhi aturan lokal yang ada dengan keberagamannya dibandingkan mematuhi hukum negara. Pembentukan pola harmonisasi budaya dalam sistem komunikasi hukum guna penegakan hukum dapat dilakukan dengan perbauran budaya pada masyarakat pluralistik. Pengaruh yang terlihat dengan adanya pola harmonisasi budaya adalah pengunaan komunikasi hukum menjadi lebih efektif dalam hal penegakan hukum
Generalized solutions of variational problems and applications
Authors: Benci Vieri , Luperi Baglini Lorenzo , Squassina Marco 
Published: August 2018

AbstractUltrafunctions are a particular class of generalized functions defined on a hyperreal fieldℝ*⊃ℝ{\mathbb{R}^{*}\supset\mathbb{R}}that allow to solve variational problems with no classical solutions. We recall the construction of ultrafunctions and we study the relationships between these generalized solutions and classical minimizing sequences. Finally, we study some examples to highlight the potential of this approach.
Rechtliche Rahmenbedingungen der Digitalisierung kulturellen Erbes
Authors: Ernst Michael 
Published: August 2018

Zusammenfassung
Die Digitalisierung bietet ein enormes Potenzial für Wissenschaft, Lehre und Forschung. Doch sind die derzeit geltenden rechtlichen Rahmenbedingungen geeignet, dieses Potenzial auszuschöpfen und gewinnbringend für alle nutzbar zu machen? Nicht nur die aufwändige Recherche nach Rechteinhabern, sondern auch die fehlenden Möglichkeiten, Digitalisate von urheberrechtlich geschützten Werken unter freien Lizenzen nachnutzbar zu machen, erschweren die praktische Umsetzung der gesellschaftlich gewünschten und vielfach auch gesetzlich geforderten digitalen Zugänglichmachung von Sammlungsgegenständen durch Kulturerbeeinrichtungen.
Performance Analysis of High Data Rate Wavelength Division Multiplexed Passive Optical Networks (WDM-PON) for Mobile Backhaul Application
Authors: Kachhatiya Vivek , Prince Shanthi 
Published: August 2018

AbstractIn this work, we propose a sixteen channel wavelength division multiplexed passive optical network (WDM-PON) architecture which provides seamless connectivity between mobile switching center (MSC) and base transceiver stations (BTS) and also serves the fiber to the home (FTTH) users. WDM-PON based mobile backhaul network is considered to be a prime solution due to its quick deployment and reduced cost. Due to growing demand for connectivity and data transmission, the number of wavelengths are increasing day by day. The bit error rate (BER) performance is analyzed for the discrete data rates per wavelength (viz. 2.5 Gbps, 5 Gbps, 10 Gbps, 20 Gbps, and 40 Gbps) at discrete reach for 16 channel WDM-PON. The optical spectrum of sixteen channel WDM-PON is observed for different data rates at multiplexer output and the same is analyzed after fiber distance of 20 km. The fiber reach of the WDM-PON is varied, and its effect on the performance parameter like bit error rate (BER) and Quality Factor (Q-Factor) is observed on BER analyzer for the discrete data rates per wavelength. It is found that as data rate per wavelength increases, the error-free reach of the WDM-PON system decreases. Proposed WDM-PON architecture performs superior to the compared work under similar initial conditions.
Green vegetation: a promising source of color dyes
Authors: Jaffer Mehwish , Shaheen Shabnum , Ashraf Hammad , Hanif Uzma 
Published: August 2018

AbstractThe present study aimed for the extraction of color dyes from different sources, such asBrassica oleracea,Brassica campestris,Citrus limon,Citrus limetta,Tagetes erecta,Spinacea oleracea,Beta vulgaris,Rosa indicaandCurcuma longa.The leftovers of such plants were mainly used for color dye extraction and their confirmation using spectrophotometric analysis. The specific color pigments like carotenoids, anthocyanin, chlorophyll and betanin were found to be the main coloring agents that impart specific color to the samples. Among all these samples, the maximum yield was obtained fromC. limettaaqueous peel extract, and among all the temperatures employed room temperature was found out to be the most suitable temperature for the stability of color extracts. The extracted colors were utilized in candy making and sugar syrup making and were also used for coloring various foods stuffs. Moreover, the extracted color dyes were applied for dyeing purposes on cotton cloth with alum showing better and more enhancing color fastness results than the lime.