bluuebunny/crossref_metadata_2025_split huggingface dataset:
A minimally invasive technique to remove broken cemented stems and its reconstruction with cement-in-cement
Authors: Burgo Federico J , Mengelle Diego E , Feijoo Maecelo , Autorino Carlos M 
Published: December 2018

Introduction: Historically the removal of fractured stems was associated with complex revision and loss of bone stock. This study describes a minimally invasive procedure for extraction of the distal part of a broken cemented stem that does not compromise the bone stock and results with the cement-in-cement reconstruction technique. Materials and method: 7 patients with an average age of 74 years who underwent total hip replacement (THR) revision for fracture of femoral stems were included. The average follow-up was 8.7 years. For the removal of the distal fragment of the broken stem, a set of instruments have been manufactured using a coupling through the wrought of a thread over the fractured face of the stem. 6 cases were reconstructed using a cement-in-cement technique. In 1 case an extended trochanteric osteotomy was required. Results: There were no complications associated with the surgical technique. Early rehabilitation and standing were achieved in all patients at 48 hours postoperatively. No patient required a blood transfusion. No clinical or radiological loosening was detected at final follow-up. Conclusions: Different methods have been described for the extraction of distal fragments of a broken femoral stem. The majority include the use of femoral osteotomies, bone windows and knee arthrotomies. These techniques are associated with bone loss and bleeding. The advantages of the method described are, its low complexity, low-cost, accelerated functional recovery and the preservation of bone stock with the possibility of performing cement-in-cement reconstruction techniques.
Creating a meaningful everyday life: Perceptions of relatives of people with dementia and healthcare professionals in the context of a Danish dementia village
Authors: Peoples Hanne , Pedersen Line Friis , Moestrup Lene 
Published: December 2018

Background The world’s aging population contributes to an increase in people living with dementia, which is perceived as one of the main causes of disability and dependency for older people. The first dementia village in Denmark was established in 2015, with the intention of providing a safe and meaningful everyday life for people with dementia. The purpose of the study was to explore the way in which relatives of people with dementia and healthcare professionals create and maintain a meaningful everyday life for the residents in a Danish dementia village. Methods A methodology for user involvement in public service development and evaluation called ‘The BIKVA methodology’ was used followed by a thematic analysis. A purposive sample of 32 participants took part in the study. Results The analysis revealed one main theme, ‘Enabling a familiar and meaningful everyday life in the dementia village’, with three corresponding subthemes, reflecting the way in which relatives of people with dementia and healthcare professionals create and maintain a meaningful everyday life for the residents in a Danish dementia village. Conclusion The findings showed that relatives of people with dementia and healthcare professionals were committed to creating and maintaining a meaningful everyday life for the residents, but also revealed different understandings of when, where, and how this could be understood and best be achieved. Furthermore, people with advanced dementia may not be able to benefit from the activities and possibilities provided by the dementia village, since this required resources beyond what could be provided.
Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein
Authors: Han Ke-Jun , Wu Zhiping , Pearson Chad G. , Peng Junmin , Song Kunhua , Liu Chang-Wei 
Published: December 2018

ABSTRACT
Centriolar satellites are small cytoplasmic granules that play important roles in regulating the formation of centrosomes and primary cilia. Ubiquitylation of satellite proteins, including the core satellite scaffold protein pericentriolar material 1 (PCM1), regulates centriolar satellite integrity. Currently, deubiquitylases that control centriolar satellite integrity have not been identified. In this study, we find that the deubiquitylase USP9X binds PCM1, and antagonizes PCM1 ubiquitylation to protect it from proteasomal degradation. Knockdown of USP9X in human cell lines reduces PCM1 protein levels, disrupts centriolar satellite particles and causes localization of satellite proteins, such as CEP290, to centrosomes. Interestingly, knockdown of mindbomb 1 (MIB1), a ubiquitin ligase that promotes PCM1 ubiquitylation and degradation, in USP9X-depleted cells largely restores PCM1 protein levels and corrects defects caused by the loss of USP9X. Overall, our study reveals that USP9X is a constituent of centriolar satellites and functions to maintain centriolar satellite integrity by stabilizing PCM1.
Upf1 regulates neurite outgrowth and branching by transcriptional and post-transcriptional modulation of Arc
Authors: Ryu Hye Guk , Seo Ji-Young , Jung Youngseob , Kim Sung Wook , Kim Eunah , Jang Sung Key , Kim Kyong-Tai 
Published: December 2018

ABSTRACT
A large number of neuronal proteins must show correct spatiotemporal localization in order to carry out their critical functions. The mRNA transcript for the somatodendritic protein activity-regulated cytoskeleton-associated protein (Arc; also known as Arg3.1) contains two conserved introns in the 3′ untranslated region (UTR), and was proposed to be a natural target for nonsense-mediated mRNA decay (NMD). However, a well-known NMD component Upf1 has differential roles in transcriptional and translational regulation of Arc gene expression. Specifically, Upf1 suppresses Arc transcription by enhancing destabilization of mRNAs encoding various transcription factors, including Mef2a. Upf1 also binds to the Arc 3′UTR, resulting in suppression of translation. Surprisingly, the Arc transcript escapes from Upf1-mediated NMD by binding to Ago2 (also known as miRISC), which blocks NMD and further suppresses Arc mRNA translation. Upf1 knockdown triggered sustained Arc expression, which contributes to Cofilin (also known as Cfl1) hyperphosphorylation and abnormal neuronal outgrowth and branching. Collectively, these data reveal that multiple levels of Upf1-mediated inhibition of Arc gene expression may allow neurons to more effectively respond to changes in neuronal activity.
Association of JJ stent insertion and sexual function: A cohort study
Authors: Fawzi Rizky , Ali Zulfikar 
Published: December 2018

Background: Indonesia is known as one of the world’s stone belt areas in Asia. Management of urolithiasis cannot be separated with the role of JJ stent insertion. However, a limited number of prior studies show that a patient with JJ stent is at risk for sexual function disorder. This study aims to evaluate the association of JJ stent insertion with sexual function, both in men and women. Methods: This is a cohort study and the subjects were patients who had undergone JJ stent insertion in July - November 2017 at Kardinah Regional Hospital, Tegal, Central Java. This study was approved by the Research Ethic Committee of Kardinah Hospital (#445/3840/2017). Data were taken using standardized self-administered questionnaires before and after insertion of the JJ stent. Male sexual function was assessed using the International Index of Erectile Function (IIEF) score, while female sexual function was assessed using Female Sexual Function Index (FSFI). Result: 60 male patients, with a mean of age 51.1 + 10.6 years, and 33 female patients, with mean of age 49.6 + 10.6 years old, underwent JJ stent insertion. A significant association was found in women before and after JJ stent insertion (p<0.05), with FSFI score 23.62 + 0.64 before insertion and 16.7 + 0.52 after insertion. A similar result was also found in men with total IIEF score 49.55 + 2.3 before JJ stent insertion and 38.4 + 1.7 after insertion. Conclusion: This study confirms that JJ stent insertion may cause a disturbance of sexual function. However, the mechanism is not clear yet.
A mindful model of sexual health: A review and implications of the model for the treatment of individuals with compulsive sexual behavior disorder
Authors: Blycker Gretchen R. , Potenza Marc N. 
Published: December 2018

Background and aims
Mindfulness-based approaches, derived from centuries of eastern philosophy and practice, have been increasingly incorporated into western medicine. For example, data support the efficacy of mindfulness-based therapies to reduce stress and promote mental health.

Methods
In this study, we briefly review models and approaches to sexual health in the context of considering compulsive sexual behavior disorder, describe mindfulness-based approaches to stress, addiction, and compulsive sexual behaviors, and present a Mindful Model of Sexual Health (MMSH) that incorporates elements of eastern and western philosophies. We further illustrate the clinical utility of the MMSH in a clinical case description.

Results
We propose the MMSH as a holistic and integrative model that honors and acknowledges individual differences and provides mindfulness-based tools and practices to support individuals to proactively manage, balance, and promote sexual and mental health. The MMSH may be used as a framework to organize information regarding physical, mental, emotional, sexual, and relational health, as well as a conceptual map offering navigational skills to access information within one’s mind/body to make informed decisions to promote well-being regarding sexual satisfaction and health. In its organizational structure, the MMSH is divided into eight domains that are theoretically linked to biological functions and may be used to identify and overcome barriers to sexual health through mindful inquiries in clinical practice or educational settings.

Discussion and conclusion
Given its focus on awareness of interoceptive processes through mind/body connectedness, the MMSH may resonate with a wide range of individuals, including those with compulsive sexual behavior disorder.
Orvosi rehabilitációs kezelésben részesülő betegek orális egészségügyi állapotának vizsgálata
Authors: Orsós Mercédesz , Moldvai Júlia , Kivovics Péter , Németh Orsolya 
Published: December 2018

Abstract: Introduction: More than 1 billion people in the world live with some form of disability. According to the 2011 census in Hungary, their number can be around 500 000. These people are considered as a vulnerable group even from a dental point of view, since the loss of function makes regular oral hygienic routine and dentistry control more difficult. In 2015, The Department of Community Dentistry and The National Institute of Medical Rehabilitation started to operate together a dental office to examine the dental and oral hygiene condition of the inpatients and to make their oral rehabilitation. Aim:aAim: A total of 608 patients have gone through a full dental examination including a stomato-oncological screening. From this we gathered comprehensive information on the oral health of patients currently undergoing rehabilitation and living with disabilities. Method: This study was approved by the Medical Research Council. Clinical examinations were done on the basis of the recommendation by WHO. We analysed the DMF-T values, restorative index, periodontal status and lesions of the oral mucosa. From a survey of 20 questions we asked about oral hygiene practices, toothbrushing frequency, last visit to a dentist, eating habits, addictions and social background. Results: The patients had poor oral hygiene. The number of lost teeth is high, but the prosthetic care is not satisfying. The DMF-T value was 20.5, from this D-T = 2.6, M-T = 11.2, F-T = 6.7. The patients’ complaints about dental and oral mucosal lesions are minimal compared to their general dental condition. A majority of them did not experienced toothaches in the last 12 months. The last dental checkup in the case of most patients exceeds 12 months. Conclusions: The oral hygiene of patients living with some form of disability is poor since their daily oral hygiene routine and care in practice are not solved. Orv Hetil. 2018; 159(52): 2202–2206.
The influence of BESTFertil towards male reproductive function in idiopathic fertility
Authors: Korenkov D. G. , Pavlov A. L. , Kazimzade E. D. 
Published: December 2018

The study objectiveis to evaluate the influence of complex BESTFertil on the fertility in men with idiopathic pathospermia.Materials and methods. Ninety males (from 25 to 45years old) took part in the open prospective controlled study: 60 males with idiopathic fertility were given BESTFertil (2 caps “Morning” and 2 caps “Evening” per day for the period of 3 month). Other 30 males belong to controls. The efficacy of therapeutics was evaluated according to spermatogram analysis (volume of ejaculate, sperm concentration, percentage of progressive-motile sperm (grade A + B), and percentage of degenerated forms).Results.After 3 month of treatment the ejaculate volume increased to 1,7 time, and exceeded controls up. The sperm concentration increased to 33 % (before treatment) and exceeded controls to 39 %. The percentage of progressive-motile sperm (grade A + B) was 6 times more as it was before treatment, and 89,8 % as compare to the controls. The percentage of degenerated forms of spermatozoids decreased to 32,3 % (before treatment) and was 2,9 % less then in the control group.Conclusions. Administration of BESTFertil in treatment plan of male idiopathic fertility may consider to be a promising type of therapy, which increased the records of spermatogram and promotes conception among the married couples.
Çocukların Devam Ettikleri Okul Türüne Göre Annelerin Çocuk Kitapları Hakkındaki Görüşlerinin İncelenmesi
Authors: Bayraktar Vedat , Ersoy Özlem 
Published: December 2018

Araştırma,
4-6 yaş grubu çocukların devam ettikleri okul türüne göre annelerin çocuk
kitabı hakkındaki görüşlerini tespit etmek amacıyla yapılmıştır. Araştırmada tarama
araştırması yöntemi kullanılmıştır. Araştırmaya, Ankara il merkezinde yaşayan
ve uygun örnekleme yöntemiyle seçilen toplam 500 anne katılmıştır. Veriler SPSS
20.00 paket programı kullanılarak Ki Kare (X²) ile analiz edilmiştir. Annelere,
“Okul Öncesi Dönemde Çocukları Bulunan
Annelerin Çocuk Kitabı Seçim Kriterleri Anketi” uygulanmıştır. Ankette,
annelere çocukların kendilerine kitap
alınmasını nasıl karşıladıkları, çocuklarına kitap alma nedenleri, çocuklarına
kitap alırken ne tür kitap tercih ettikleri, çocuklarına ödül ve hediye olarak
ne aldıkları, çocukların arkadaşlarına ödül ve hediye olarak ne aldıkları,
çocuklarını kütüphaneye götürme durumları, annelerin kendilerine kitap alma
sıklıkları, çocuklarına kitap alma sıklıkları ve çocuklara kitap alınırken
tercihi kimin yaptığına yönelik sorular sorulmuştur. Araştırma sonucunda; çocukların devam
ettikleri okul türüne göre
kendilerine kitap alınmasından hoşlanma durumları, kitap alma nedenleri,
çocuklarına aldıkları ödül veya hediyelerin dağılımı, çocukların arkadaşlarına
aldıkları ödül veya hediyelerin dağılımı, çocuklarını kütüphaneye götürme
durumları, annelerin kendilerine kitap alma sıklıkları, annelerin çocuklarına
kitap alma sıklıkları ve kendilerine kitap alınırken tercihi kimin yaptığı
konularında istatistiksel olarak anlamlı bir fark bulunurken; çocuklarına ne
tür kitaplar tercih ettikleri konusunda istatistiksel olarak anlamlı bir
farklılık bulunmamıştır.
Akademik Başarıya İlişkin Bilişsel Çarpıtmalar Ölçeğinin (ABİBÇÖ) Geliştirilmesi
Authors: KAYA İdris 
Published: December 2018

Bu
çalışmada, lise öğrencilerinin akademik başarıya ilişkin bilişsel
çarpıtmalarını ölçecek bir aracın geliştirilmesi ve psikometrik özelliklerinin
incelenmesi amaçlanmıştır. Araştırmanın çalışma grubu açımlayıcı faktör analizi
için 340 (= 16,28; Sd= 1,07); doğrulayıcı faktör analizi için 218 (= 15,8; Sd= 1,40), test tekrar test güvenirliği için 48 olmak üzere toplam 606 kişiden
oluşmaktadır. Ölçeğin geliştirilme sürecinde; öğrenci görüşmelerinden,
literatürden ve uzman görüşlerinden hareketle 52 maddeli bir forma
ulaşılmıştır. Elde edilen form üzerinde ilk olarak açımlayıcı faktör analizi
(AFA) yapılmıştır. AFA ve uzman görüşleri çerçevesinde 27 madde araçtan
çıkarılarak toplam varynasın %50, 87’sini açıklayan dört faktörlü, 25 maddeli
bir form elde edilmiştir. Ulaşılan dört
faktörlü yapının model uyumunu incelemek için farklı bir çalışma grubu ile
doğrulayıcı faktör analizi (DFA) yapılmış ve elde edilen sonuçlar (X2/sd= 2,29; RMSEA= .08; CFI=
.95; NNFI= .95; SRMR= .08) ölçeğin model veri uyumunun iyi düzeyde olduğunu
göstermiştir. Araçta başarısızlığı felaketleştirme ifadelerini içeren boyut
“Felaketleştirme”; kişisel değerini akademik başarı üzerinden tanımlayan
maddeleri içeren boyut “Benlik değeri” başarı veya başarısızlığı kendi
dışındaki etmenlerde arayan ifadeleri içeren boyut “Dışa atıf” başarıya dair
katı ve yüksek standartları içeren boyut ise “Mükemmeliyetçilik” olarak
isimlendirilmiştir. Ölçeğin güvenirlik analizleri sonucunda elde edilen Cronbach’s
Alfa iç tutarlılık kat sayısı (.89), test tekrar test güvenirliği (.89) ve yapısal
güvenirlik (.94) analizi sonuçları ölçeğin yeterli güvenirlik değerlerine sahip
olduğunu göstermiştir. Elde edilen bulgular 25 maddeden oluşan ABİBÇÖ’nün lise
öğrencilerinin akademik başarıya ilişkin bilişsel çarpıtmalarını
değerlendirmede geçerli ve güvenilir bir ölçme aracı olduğu göstermiştir.
Characteristics of non-hepatic cancers in cirrhotic patients
Authors: AKBAŞ Enver , ALTUN Reskan , KORKMAZ Murat 
Published: December 2018

Background
and Aims: Besides the incidence
of hepatocellular carcinoma, the incidence of some non-hepatic cancers also
increases in patients with cirrhosis. We evaluated whether there was an
increase in the incidence of non-hepatic cancers in patients with cirrhosis
diagnosed before transplantation in our center.&nbsp;Materials
and Methods: In this retrospective study, a total sample of 1017 patients with cirrhosis who were followed
up at our center was reviewed, of which the data of 37
patients who did not develop non-hepatic cancer were evaluated, and the incidence of cancer was
determined. These data were
compared with the incidence rate of cancer at our hospital.Results: The incidence of non-hepatic cancers was found
to be increased by 4-fold in males and by 9-fold in females (overall 7.5-fold)
among patients with cirrhosis compared with that in the control group (p &lt; 0.05).
Comparison based on the type of cancers in cirrhotic patients revealed an
increase by 93-fold for leukemia, 33-fold for lymphoma, 31-fold for gallbladder
cancers, 15.5-fold for gastric cancers, 12-fold for renal cell cancers, 10-fold
for sarcomas, 9-fold for urinary bladder cancers, ~6-fold for pancreatic,
laryngeal, endometrial, and lung cancers, 4-fold for prostate cancers (p &lt; 0.05), 2.5-fold for colon cancers, and 1.2-fold for
breast cancers (p
˃ 0.05).&nbsp;Conclusion: There was an increase in the incidence of all
non-hepatic cancers, primarily lymphoma and leukemia, in patients with
cirrhosis.
Sandal Ağacı (Arbutus andrachne) Yapraklarının Potansiyel Besleme Değerinin Belirlenmesi
Authors: TATLIYER Adile , KAMALAK Adem , ÖZTÜRK Durmuş 
Published: December 2018

Bu
çalışmanın amacı, hasat zamanının sandal
ağacı yapraklarının kimyasal kompozisyonuna, metabolik enerji değerine (ME) ve in vitro kuru madde sindirim derecesine
(IVKMSD) olan etkisini belirlemektir. Hasat zamanı sandal ağacı yaprağının
kompozisyonunu, İVKMSD ve ME içeriğini önemli derecede etkilemiştir. Yaprakların
İVKMSD %28.56 ile % 67.73 arasında değişmiş olup en yüksek İVKMSD’i Ocak ve
Nisan aylarında en düşük İVKMSD’ne ise Ekim ayında hasat edilen yapraklarda
bulunmuştur. Yaprakların ME içeriği % 3.11 ile %9.02 MJ/kg arasında değişmiş
olup en yüksek ME Ocak ayında ve en düşük ME değeri ise Ekim ayında hasat
edilen yapraklarda bulunmuştur. Sonuç
olarak sandal ağacı yaprağının kimyasal kompozisyonu, IVKMSD ve ME içeriği
hasat zamanına bağlı olarak değişmiştir. Dört farklı dönemde hasat edilen sandal
ağacının yapraklarının protein ve mineral içerikleri düşük olduğundan koyun ve
keçilerin ihtiyacını karşılamak için sandal ağacının yaprakları protein P, Cu
ve Mn kaynakları yeme eklenmelidir.
Anti-inflammatory and ulcerogenic activities of thiazolidine-4-ones in rats
Authors: N. Shiva Murthy , V. Srinivas , M. Shanthi 
Published: December 2018

Background: NSAIDS are associated with side effects and research should continue for developing safer drugs. This study aims to evaluate newer thiazolidine-4-ones for their anti-inflammatory and ulcerogenic activities in wister rats.Methods: Five groups of wister rats, 6 in each were used. Anti-inflammatory and ulcerogenic activities of diclofenac (30mg/kg), nimesulide (50mg/kg), thia-1 (50mg/kg) and thia-2 (50mg/kg) are compared with control group (4% Gum Acacia). Carrageenin-induced paw edema, formaline induced acute peritonitis and cotton pellet-induced granulomatous tissue formation models were used for evaluating anti-inflammatory activity. After removing cotton pellets with granuloma on 8th day gastric ulcerogenicity was assessed by using macroscopic and microscopic scoring of ulcers.Results: Diclofenac, nimesulide and thia 2 reduced both paw edema and peritoneal exudate volume significantly (p <0.01). Wet weight of cotton pellets reduced significantly (p <0.01) by diclofenac, nimesulide and thia 2. Diclofenac (p <0.01) and thia 2 (p <0.05) reduced dry weight of cotton pellets significantly. nimesulide and thia-1 reduced it by 19.14% and 2.68% respectively and was considered statistically not significant (p>0.05). Nimesulide, thia-1 and thia-2 did not increase gastric ulcer score significantly (p >0.05). Diclofenac increased ulcer score significantly (p <0.01).Conclusions: Thia-2 demonstrated significant anti-inflammatory activity in acute and chronic models. In addition to inhibition of cyclooxygenase pathway, PPAR agonistic activity may be involved in its anti-inflammatory activity. No significant ulcerogenicity was observed on comparing with nimesulide and control. Further in-vitro and in-vivo studies are recommended to confirm the results of this study.
Comparison of clinical and biochemical profile of obese and nonobese children
Authors: C. Patil Lingaraja Gowda , S Srinivas 
Published: December 2018

Background: We compared clinical and biochemical parameters of obese children aged 6 to 18 years with normal controls visiting to outpatient department in a tertiary care hospital. It was a prospective case control study.Methods: Obese children with Body Mass Index > 2 standard deviation according to WHO chart were included. Endocrinological and syndromic obese children were excluded. We described risk factors for obesity and compared clinical and biochemical parameters between cases and controls. Student’s t test, Chi-square test and ANOVA (analysis of variance) were used for statistical analysis.Results: We noted higher prevalence of intake of junk food and sedentary lifestyle in obese group. Anthropometric parameters including BMI, skin fold thickness and abdominal circumference were higher in obese children compared to control group. Both systolic and diastolic blood pressures were high in obese children compared to control group. We observed higher prevalence of insulin resistance and dyslipidaemia among obese children.Conclusions: This study reemphasises that junk foods and sedentary lifestyle are important risk factors for obesity. Always screen for glucose intolerance, hypertension, insulin resistance and dyslipidaemia in obese children.