bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep determines quality of life in autistic adults: A longitudinal study
Authors: Deserno Marie K. , Borsboom Denny , Begeer Sander , Agelink van Rentergem Joost A. , Mataw Kawita , Geurts Hilde M. 
Published: April 2019

Many individuals with autism report generally low quality of life (QoL). Identifying predictors for pathways underlying this outcome is an urgent priority. We aim to examine multivariate patterns that predict later subjective and objective QoL in autistic individuals. Autistic characteristics, comorbid complaints, aspects of daily functioning, and demographics were assessed online in a 2‐year longitudinal study with 598 autistic adults. Regression trees were fitted to baseline data to identify factors that could predict QoL at follow‐up. We found that sleep problems are an important predictor of later subjective QoL, while the subjective experience of a person's societal contribution is important when it comes to predicting the level of daily activities. Sleep problems are the most important predictor of QoL in autistic adults and may offer an important treatment target for improving QoL. Our results additionally suggest that social satisfaction can buffer this association.Autism Research2019, 12: 794–801. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryMany individuals with autism report generally low quality of life (QoL). In this study, we looked at factors that predict long‐term QoL and found that sleep problems are highly influential. Our results additionally suggest that social satisfaction can buffer this influence. These findings suggest that sleep and social satisfaction could be monitored to increase QoL in autistic adults.
Modeling, simulation and life‐cycle assessment of the use of bio‐oil and char in conventional refineries
Authors: Cruz Pedro L. , Iribarren Diego , Dufour Javier 
Published: April 2019

AbstractIn this article we address the environmental assessment of the coprocessing of biomass‐based feedstock in crude oil refineries. In particular, we consider the coprocessing of bio‐oil (from the pyrolysis of lignocellulosic biomass) in fluid catalytic cracking and hydrocracking units, and the cogasification of pyrolysis char (coproduced with bio‐oil) with coke. In addition to a conventional fossil‐based refinery used as the base case, we simulate three alternative case studies including different biofeedstock coprocessing layouts based on original models validated against experimental data. We use process simulation as a primary source of data for the life‐cycle assessment (LCA) of each case study. The LCA results show that the system's carbon footprint per energy output is improved when including biofeedstock coprocessing, favoring the study with the highest biofeedstock use. However, the results for other life‐cycle indicators such as the abiotic depletion of elements and eutrophication lead to unfavorable results for biofeedstock coprocessing, which is mainly due to the increased use of catalysts and the need for fertilizers. Hence, the suitability of a specific coprocessing layout will be ultimately conditioned by the performance indicators prioritized by the actors involved in the decision‐making process. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd
Special education teachers’ experienced burnout and perceived fit with the professional community: A 5‐year follow‐up study
Authors: Soini T. , Pietarinen J. , Pyhältö K. , Haverinen K. , Jindal‐Snape D. , Kontu E. 
Published: April 2019

In many countries, including in Finland, promoting inclusive school practices supporting pupils’ equal rights for learning is the focus of school development. Special education teachers play a central intermediary role in developing inclusive school and classroom practices by providing support both for pupils and peer teachers. This may increase their risk of experiencing exhaustion, cynicism towards the teacher community and/or inadequacy in pupil–teacher relationships. However, the resources of a school's social working environment experienced as a functional teacher–working environment fit may buffer the risk of developing burnout. This study aims to gain a better understanding of the interrelation between, and development of, special education teachers’ experienced burnout symptoms and perceived teacher–working environment fit across time. The longitudinal study included two measurements (in year 2010, n = 760 and in year 2016, n = 485). The results show that special education teachers’ experienced inadequacy in pupil–teacher relationships predicted teacher exhaustion, cynicism towards the teacher community and inadequacy in pupil–teacher relationships 5 years later. Moreover, a perceived good teacher–working environment fit predicted lower cynicism towards the teacher community 5 years later.
Describing teacher conceptions of technology in authentic science inquiry using technological pedagogical content knowledge as a lens
Authors: Mishra Chandrani , Ha Soo Jung , Parker Loran Carleton , L. Clase Kari 
Published: April 2019

AbstractTechnology has become an indispensable component of both modern life science and life science education. However, due to inadequate knowledge and experience, teachers are often unable to include technology essential for practicing science in their teaching. In this regard, professional development workshops for in‐service and preservice teachers are beneficial. In this study, we described the role of a professional development workshop in enhancing teachers' technological, pedagogical, and content knowledge through the lens of Technological Pedagogical Content Knowledge framework. Our study is also an example of how teachers can be informed about the current trends in modern research and technology and trained to bring similar research into their classroom. © 2019 International Union of Biochemistry and Molecular Biology, 47(4):380–387, 2019.
Examining green policy and sustainable development from the perspective of differentiation and strategic alignment
Authors: Ling Ya Hui 
Published: April 2019

AbstractThe study seeks to explain the influence of green policy on sustainable development from the perspective of differentiation and strategic alignment. The study examined the relationships among a divergent green management strategy, green competencies, and firm performance. The results indicate that a divergent green management strategy is associated with higher firm performance and that such relationship is moderated by green competencies. The study confirms that a differentiation strategy pays off for firms that implement green management. The study also confirms that green policy should consider the strategic alignment between green management strategy and green competencies.
Metformin reduces prostate cancer risk among men with benign prostatic hyperplasia: A nationwide population‐based cohort study
Authors: Kuo Yu‐Jui , Sung Fung‐Chang , Hsieh Po‐Fan , Chang Hui‐Ping , Wu Kun‐Ling , Wu Hsi‐Chin 
Published: April 2019

AbstractBenign Prostate Hyperplasia (BPH) has been associated with prostate cancer prevalent among men after 50 years of age, however, it is unclear whether the antidiabetic drug, metformin, can reduce prostate cancer for men with BPH. The insurance claims data of men aged 50 years or older, with both type 2 diabetes mellitus (T2DM) and BPH diagnosed from 1997 to 2007 were analyzed. Individuals were followed up for at least 5 years. We identified 2906 and 2906 patients as the metformin cohort and nonmetformin cohort, respectively. The Cox method analysis showed that the metformin cohort had an adjusted hazard ratio (aHR) of 0.69 (95% confidence interval [CI] = 0.49‐0.96, P = 0.0298) for prostate cancer, compared to the nonmetformin cohort after controlling for age, traditional Chinese medicine (TCM) use, prostate specific antigen, and Charlson comorbidity index. Patients using TCM for BPH (per 6 months) also had an aHR of 0.41 (95% CI = 0.24‐0.69; P = 0.0009). In conclusion, both metformin medication and TCM use could be associated with reduced risk of prostate cancer for men with BPH and diabetes.
Circulating PD‐1 (+) cells may participate in immune evasion in peripheral T‐cell lymphoma and chidamide enhance antitumor activity of PD‐1 (+) cells
Authors: Zhang Wei , Shen Haorui , Zhang Yan , Wang Wei , Hu Shaoxuan , Zou Dongmei , Zhou Daobin 
Published: April 2019

AbstractPeripheral T‐cell lymphoma (PTCL) is a heterogeneous disease with poor outcomes. We intend to explore the role of circulating PD‐1 (+) cells in tumor immune evasion in PTCL patients and the mechanism of chidamide as a regulator of immune‐associated medicine on PD‐1 (+) cells. Gene expression profiling (GEP) was performed on circulating PD‐1 (+) cells from 22 PTCL patients and 13 healthy subjects, and circulating PD‐1 (−) cells from 2 PTCL patients. PD‐1 (+) cells were treated with chidamide, and the production IFN‐γ and cytotoxicity were analyzed. GEP were performed on circulating PD‐1 (+) cells from 2 PTCL patients treated with chidamide combined with chemotherapy and 1 patient treated with traditional chemotherapy. GEP showed that genes associated with innate immune response were abnormally expressed in PD‐1 (+) cells of PTCL patients compared with healthy subjects, meanwhile the expression of CTLA‐4 was significantly higher in PD‐1 (+) cells than that of PD‐1 (−) cells. In vitro study revealed decreased level of IFN‐γ secretion and impaired cytotoxic activity of PD‐1 (+) cells compared with PD‐1 (−) cells, while chidamide could recover the deficiencies and upregulate adaptive immune‐associated genes in PD‐1 (+) cells of PTCL patients. Our research indicated that PD‐1 (+) cells might have deficiencies in innate and adaptive immune response and chidamide may reverse the defects.
Acute kidney injury predicts all‐cause mortality in patients with cancer
Authors: Kang Eunjeong , Park Minsu , Park Peong Gang , Park Namyong , Jung Younglee , Kang U , Kang Hee Gyung , Kim Dong Ki , Oh Kook‐Hwan , Joo Kwon Wook , Kim Yon Su , Yoon Hyung-Jin , Lee Hajeong 
Published: April 2019

AbstractBackgroundAcute kidney injury (AKI) is a critical issue in cancer patients because it is not only a morbid complication but also able to interrupt timely diagnostic evaluation or planned optimal treatment. However, the impact of AKI on overall mortality in cancer patients remains unclear.MethodsWe conducted a retrospective cohort study of 67 986 cancer patients, from 2004 to 2013 to evaluate the relationship between AKI and all‐cause mortality. We used KDIGO AKI definition and grading system.ResultsDuring 3.9 ± 3.1 years of follow‐up, 33.8% of the patients experienced AKI at least once. Among AKI events, stage 1, 2, and 3 was 71.0%, 13.8%, and 15.1%, respectively. AKI incidence was highest in hematologic malignancies, followed by urinary tract cancer, and hepatocellular carcinoma. Male sex, older age, underlying diabetes and hypertension, lower serum albumin and plasma hemoglobin, more frequent radio‐contrast exposure, entrance of clinical trials, and receiving chemotherapy were associated with AKI occurrence. AKI development was an independent risk factor for elevated mortality in cancer patients with dose‐responsive manner (Stage 1, hazard ratio [HR] 1.183, 95% confidence interval [CI] 1.145‐1.221, P < 0.001; Stage 2, HR 1.710, 95% CI 1.629‐1.796; Stage 3, HR 2.000, 95% CI 1.910‐2.095; No AKI, reference group) even after adjustment. This tendency was reproduced in various cancer types except thyroid cancer and in various treatment modalities, however, not shown in patients with baseline renal dysfunction.ConclusionAKI was an independent risk factor for all‐cause mortality in overall cancer patients with dose‐responsive manner.
Systematic evaluation of cancer‐specific genetic risk score for 11 types of cancer in The Cancer Genome Atlas and Electronic Medical Records and Genomics cohorts
Authors: Shi Zhuqing , Yu Hongjie , Wu Yishuo , Lin Xiaoling , Bao Quanwa , Jia Haifei , Perschon Chelsea , Duggan David , Helfand Brian T. , Zheng Siqun L. , Xu Jianfeng 
Published: April 2019

AbstractBackgroundGenetic risk score (GRS) is an odds ratio (OR)‐weighted and population‐standardized method for measuring cumulative effect of multiple risk‐associated single nucleotide polymorphisms (SNPs). We hypothesize that GRS is a valid tool for risk assessment of most common cancers.MethodsUtilizing genotype and phenotype data from The Cancer Genome Atlas (TCGA) and Electronic Medical Records and Genomics (eMERGE), we tested 11 cancer‐specific GRSs (bladder, breast, colorectal, glioma, lung, melanoma, ovarian, pancreatic, prostate, renal, and thyroid cancer) for association with the respective cancer type. Cancer‐specific GRSs were calculated, for the first time in these cohorts, based on previously published risk‐associated SNPs using the Caucasian subjects in these two cohorts.ResultsMean cancer‐specific GRS in the population controls of eMERGE approximated the expected value of 1.00 (between 0.98 and 1.02) for all 11 types of cancer. Mean cancer‐specific GRS was consistently higher in respective cancer patients than controls for all 11 types of cancer (P < 0.05). When subjects were categorized into low‐, average‐, and high‐risk groups based on cancer‐specific GRS (<0.5, 0.5‐1.5, and >1.5, respectively), significant dose‐response associations of higher cancer‐specific GRS with higher OR of respective type of cancer were found for nine types of cancer (P‐trend < 0.05). More than 64% subjects in the population controls of eMERGE can be classified as high risk for at least one type of these cancers.ConclusionValidity of GRS for predicting cancer risk is demonstrated for most types of cancer. If confirmed in larger studies, cancer‐specific GRS may have the potential for developing personalized cancer screening strategy.
Towards identifying customer profiles in reactions to financial overcompensation: The role of self‐interest and fairness sensitivity in explaining who prefers more money
Authors: Haesevoets Tessa , Van Hiel Alain , Pandelaere Mario , De Cremer David 
Published: April 2019

AbstractIn the aftermath of a product failure, companies often offer a financial compensation. The present research compares the effects of equal compensation (i.e., a refund that is equivalent to the purchase price) and large overcompensation (i.e., a refund that is five times larger than the purchase price) on customer loyalty, which was hypothesized to be moderated by individual differences in self‐interest and fairness sensitivity. Our results, first of all, revealed that, overall, large overcompensation does not result in higher customer loyalty than equal compensation. Although overcompensation does not appear to be a worthwhile strategy in general, our results also showed that large overcompensation nonetheless entails positive effects for a particular type of customer. Indeed, relative to equal compensation, overcompensation had an incremental effect on customer loyalty for customers low on perpetrator fairness sensitivity and for customers high on victim fairness sensitivity. Variables related to self‐interest (i.e., materialism and greed) did not demonstrate such a moderation effect. Theoretical and practical implications are discussed.
Chemodiversity of Essential Oils in Seseli libanotis (L.) W.D.J.Koch (Apiaceae) in Central Europe
Authors: Chizzola Remigius 
Published: April 2019

AbstractSeseli libanotis is an aromatic umbelliferous plant distributed sporadically on dry grassland edges in Europe and Western Asia. The essential oil composition in the different plant parts was studied from plants collected on nine sites in Austria and one site in Alto Adige, Italy. Monoterpenes such as α‐pinene, sabinene and β‐myrcene and the sesquiterpene germacrene D were present in all essential oils from the aerial parts. Inflorescences and fruits had the highest essential oil contents. These essential oils from four sites were rich in acorenone B, while from other three sites they had carotol as a major component. Osthole as furocoumarin occurred in some oils. The root essential oils were dominated by α‐pinene. The essential oil variability has been studied by principal component analysis (PCA) and discriminant analysis (DA) with plant parts or sampling site as a priori groups. PCA could well separate inflorescence and fruit essential oil samples from leaf and stem essential oil samples. DA differentiated well between the plant parts and most of the sampling sites.
Breast implant–associated anaplastic large‐cell lymphoma
Authors: Collins Katrina , DiGiuseppe Joseph A. 
Published: April 2019

Key Clinical MessageIn patients with suspected breast implant–associated anaplastic large‐cell lymphoma, cytologic evaluation of fine‐needle aspirate specimens from the peri‐implant seroma, together with flow cytometric immunophenotyping and immunohistochemistry, represents a suitable preoperative diagnostic approach when planning for surgical management.
Online discrimination of chemical substances using standoff laser‐induced fluorescence signals
Authors: Kraus Marian , Gebert Florian , Walter Arne , Pargmann Carsten , Duschek Frank 
Published: April 2019

AbstractChemical contamination of objects and surfaces, caused by accident or on purpose, is a common security issue. Immediate countermeasures depend on the class of risk and consequently on the characteristics of the substances. Laser‐based standoff detection techniques can help to provide information about the thread without direct contact of humans to the hazardous materials. This article explains a data acquisition and classification procedure for laser‐induced fluorescence spectra of several chemical agents. The substances are excited from a distance of 3.5 m by laser pulses of two UV wavelengths (266 and 355 nm) with less than 0.1 mJ per laser pulse and a repetition rate of 100 Hz. Each pair of simultaneously emitted laser pulses is separated using an optical delay line. Every measurement consists of a dataset of 100 spectra per wavelength containing the signal intensities in the spectral range from 250 to 680 nm, recorded by a 32‐channel photo multiplying tube array. Based on this dataset, three classification algorithms are trained which can distinguish the samples by their single spectra with an accuracy of over 98%. These predictive models, generated with decision trees, support vector machines, and neural networks, can identify all agents (eg, benzaldehyde, isoproturon, and piperine) within the current set of substances.
Hitherto‐Unexplored Photodynamic Therapy of Ag2S and Enhanced Regulation Based on Polydopamine In Vitro and Vivo
Authors: Cheng Kai , Zhang Xiao‐Shuai , An Jie , Li Cheng , Zhang Ruo‐Yun , Ye Run , Ye Bang‐Jiao , Liu Bo , Zhao Yuan‐Di 
Published: April 2019

AbstractGiven their superior penetration depths, photosensitizers with longer absorption wavelengths present broader application prospects in photodynamic therapy (PDT). Herein, Ag2S quantum dots were discovered, for the first time, to be capable of killing tumor cells through the photodynamic route by near‐infrared light irradiation, which means relatively less excitation of the probe compared with traditional photosensitizers absorbing short wavelengths. On modification with polydopamine (PDA), PDA‐Ag2S was obtained, which showed outstanding capacity for inducing reactive oxygen species (increased by 1.69 times). With the addition of PDA, Ag2S had more opportunities to react with surrounding O2, which was demonstrated by typical triplet electron spin resonance (ESR) analysis. Furthermore, the PDT effects of Ag2S and PDA‐Ag2S achieved at longer wavelengths were almost identical to the effects produced at 660 nm, which was proved by studies in vitro. PDA‐Ag2S showed distinctly better therapeutic effects than Ag2S in experiments in vivo, which further validated the enhanced regulatory effect of PDA. Altogether, a new photosensitizer with longer absorption wavelength was developed by using the hitherto‐unexplored photodynamic function of Ag2S quantum dots, which extended and enhanced the regulatory effect originating from PDA.
3D Organic–Inorganic Perovskite Ferroelastic Materials with Two Ferroelastic Phases: [Et3P(CH2)2F][Mn(dca)3] and [Et3P(CH2)2Cl][Mn(dca)3]
Authors: Zhao Meng‐Meng , Zhou Lin , Shi Ping‐Ping , Zheng Xuan , Chen Xiao‐Gang , Gao Ji‐Xing , He Lei , Ye Qiong , Liu Cai‐Ming , Fu Da‐Wei 
Published: April 2019

AbstractOrganic–inorganic hybrid perovskite‐type multiferroics have attracted considerable research interest owing to their fundamental scientific significance and promising technological applications in sensors and multiple‐state memories. The recent achievements with divalent metal dicyanamide compounds revealed such malleable frameworks as a unique platform for developing novel functional materials. Herein, two 3D organic–inorganic hybrid perovskites [Et3P(CH2)2F][Mn(dca)3] (1) and [Et3P(CH2)2Cl][Mn(dca)3] (2) (dca=dicyanamide, N(CN)2−) are presented. Accompanying the sequential phase transitions, they display a broad range of intriguing physical properties, including above room temperature ferroelastic behavior, switchable dielectricity, and low‐temperature antiferromagnetic ordering (Tc=2.4 K for both 1 and 2). It is also worth noting that the spontaneous strain value of 1 is far beyond that of 2 in the first ferroelastic phase, as a result of the precise halogen substitution. From the point view of molecular design, this work should inspire further exploration of multifunctional molecular materials with desirable properties.
Iron‐Catalysed Remote C(sp3)−H Azidation of O‐Acyl Oximes and N‐Acyloxy Imidates Enabled by 1,5‐Hydrogen Atom Transfer of Iminyl and Imidate Radicals: Synthesis of γ‐Azido Ketones and β‐Azido Alcohols
Authors: Torres‐Ochoa Rubén O. , Leclair Alexandre , Wang Qian , Zhu Jieping 
Published: April 2019

AbstractIn the presence of a catalytic amount of iron(III) acetylacetonate [Fe(acac)3], the reaction of structurally diverse ketoxime esters with trimethylsilyl azide (TMSN3) afforded γ‐azido ketones in good to excellent yields. This unprecedented distal γ‐C(sp3)−H bond azidation reaction went through a sequence of reductive generation of an iminyl radical, 1,5‐hydrogen atom transfer (1,5‐HAT) and iron‐mediated redox azido transfer to the translocated carbon radical. TMSN3 served not only as a nitrogen source to functionalise the unactivated C(sp3)−H bond, but also as a reductant to generate the catalytically active FeII species in situ. Based on the same principle, a novel β‐C(sp3)−H functionalisation of alcohols via N‐acyloxy imidates was subsequently realised, leading, after hydrolysis of the resulting ester, to β‐azido alcohols, which are important building blocks in organic and medicinal chemistry.
Activation of SO2 by N/Si+ and N/B Frustrated Lewis Pairs: Experimental and Theoretical Comparison with CO2 Activation
Authors: Adenot Aurélien , von Wolff Niklas , Lefèvre Guillaume , Berthet Jean‐Claude , Thuéry Pierre , Cantat Thibault 
Published: April 2019

AbstractThe guanidine 1,5,7‐triazabicyclo[4.4.0]dec‐5‐ene (TBD) and the substituted derivatives [TBD–SiR2]+ and TBD–BR2 reacted with SO2 to give different FLP–SO2 adducts. Molecular structures, elucidated by X‐ray diffraction, showed some structural similarities with the analogous CO2 adducts. Thermodynamic stabilities were both experimentally evidenced and computed through DFT calculations. The underlying parameters governing the relative stabilities of the different SO2 and CO2 adducts were discussed from a theoretical standpoint, with a focus on the influence of the Lewis acidic moiety.