bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender Differences in Academic Rank and NIH Funding among Academic Maternal–Fetal Medicine Physicians in the United States
Authors: Sperling Jeffrey , Shulman Rachel , Blat Cinthia , Miller Edward , Kokroko Jolene , Zlatnik Marya , Gonzalez-Velez Juan , Norton Mary , Gossett Dana 
Published: November 2018

Objective This article evaluates gender differences in academic rank and National Institutes of Health (NIH) funding among academic maternal–fetal medicine (MFM) physicians.
Study Design This was a cross-sectional study of board-certified academic MFM physicians. Physicians were identified in July 2017 from the MFM fellowship Web sites. Academic rank and receipt of any NIH funding were compared by gender. Data on potential confounders were collected, including years since board certification, region of practice, additional degrees, number of publications, and h-index.
Results We identified 659 MFM physicians at 72 institutions, 312 (47.3%) male and 347 (52.7%) female. There were 246 (37.3%) full, 163 (24.7%) associate, and 250 (37.9%) assistant professors. Among the 154 (23.4%) MFM physicians with NIH funding, 89 (57.8%) were male and 65 (42.2%) were female (p = 0.003). Adjusting for potential confounders, male MFM physicians were twice as likely to hold a higher academic rank than female MFM physicians (adjusted odds ratio [aOR], 2.04 [95% confidence interval, 1.39–2.94], p < 0.001). There was no difference in NIH funding between male and female MFM physicians (aOR, 1.23 [0.79–1.92], p = 0.36).
Conclusion Compared with female academic MFM physicians, male academic MFM physicians were twice as likely to hold a higher academic rank but were no more likely to receive NIH funding.
Wound Closure in Flexion versus Extension following Total Knee Replacement: Outcomes and Complications
Authors: Mahmood Aatif , Fursdon Thomas , Peter Viju , Kumar Gunasekaran 
Published: November 2018

AbstractPosition of the knee may affect the range of movement (ROM) after a total knee replacement (TKR). It has been postulated that wound closure in extension may cause shortening of the extensor mechanism and increased tension on the soft tissues. The aim of this study was to determine effect of wound closure in TKR with the knee in flexion or extension on postoperative ROM and rehabilitation. A consecutive series of 121 patients underwent primary TKR between May 2011 and August 2012. Group A (60 patients) had wound closure in extension. Group B (61 patients) had wound closure in flexion. Baseline demographic data were compared—age, body mass index, gender, American Society of Anesthetists status, length of stay, wound healing, and ROM. Oxford Knee Score (OKS) were assessed at 6 months, 1 year, and 2 years. Fifty-two males and 69 females with average age of 68 years (32–86) underwent TKR. There were no wound complications requiring surgical intervention. One patient in each group required manipulation under anesthesia for stiffness. There was no statistical difference in ROM and OKS at the last follow-up. There was no difference in outcomes following knee closure in flexion or extension.
Evaluation of Femoral–Tibial Flexion Gap in Total Knee Arthroplasty with Everted or Lateralized Patella
Authors: Malavolta Michele , Cochetti Andrea , Mezzari Silvio , Residori Alberto , Lista Gianpietro 
Published: November 2018

AbstractIntraoperative patellar position (eversion, lateralization, or in situ) influences the ligamentous balancing in knee flexion and thereby the correct positioning of the femoral component during total knee arthroplasty. The correct ligament balancing is crucial when, as in our experience, prostheses with medial pivot design are used. It was shown that the flexion gap in the normal knee is not rectangular and that the lateral compartment is significantly slacker than the medial. Therefore, to obtain a correct kinematics of a medial pivot anatomical prosthesis, it is essential to recreate an anatomical flexion gap slacker in the lateral compartment. We conducted a prospective study on a consecutive series of 87 total knee prostheses. The objective of this study is to evaluate the femoral external rotation angle in each patient with everted patella as well as with pure subluxated patella. The purpose of this study is to offer guidance about the optimal femoral rotation angle to achieve best outcomes of a knee replacement. The evaluation was done using an instrument developed by Medacta International (Switzerland) with our direct collaboration (Tensor, Medacta, Switzerland) and standardizing the basic conditions of each patient (knee 90 degrees flexed, medial transquadricipital surgical access, lateral displacement of the patella, tourniquet inflated at 250 mm Hg, spinal anesthesia). Each group was subdivided into subgroups according to gender, preoperative varus or valgus deformity, and patellar height. Our study advises against evaluating the flexion gap with everted patella due to high risk of underestimation of the lateral compartment laxity (differences up to + 3 degrees with pure subluxated patella compared with everted patella).
Comparing Postpartum Visit Attendance with a Scheduled 2- to 3-Week or 6-Week Visit after Delivery
Authors: Chen Melissa J. , Hsia Jennifer K. , Hou Melody Y. , Wilson Machelle D. , Creinin Mitchell D. 
Published: November 2018

Objective To evaluate whether scheduling a 2- to 3-week versus 6-week postpartum visit results in higher visit attendance.
Study Design We conducted a secondary analysis of a quasi-experimental before–after study to compare postpartum visit attendance after changing routine scheduling of visits from 6 weeks to 2 to 3 weeks after delivery. Secondary outcomes include patient satisfaction and breastfeeding continuation at 3 and 6 months postpartum. We collected postpartum visit information through a chart review and conducted telephonic interviews at 3 and 6 months postpartum to assess satisfaction with visit timing and breastfeeding status. We performed multivariable analyses to assess predictors of visit attendance.
Results Women scheduled at 2 to 3 weeks postpartum demonstrated higher visit attendance (90.2%; 95% confidence interval [CI]: 86.6–93.9%) compared with 6 weeks (81.6%; 95% CI: 76.3–86.2%; p < 0.01). Predictors for visit attendance include postpartum visit timing, age, education, parity, prior miscarriage, and high-risk index pregnancy in multivariate analysis. Scheduling at 2 to 3 weeks postpartum increased visit completion in women who were younger and had lower educational attainment, high-risk index pregnancy, and no prior miscarriages. We found no differences in patient satisfaction or breastfeeding continuation at 3 and 6 months postpartum related to postpartum visit timing.
Conclusion Scheduling a 2- to 3-week postpartum visit is associated with higher attendance.
Undivided Retromandibular Vein Leading to the Absence of External Jugular Vein
Authors: Rao Y. , Ballal Vaishnavi , Murlimanju B. , Pai Mangala , Tonse Mamatha , Krishnamurthy Ashwin 
Published: November 2018

AbstractWe report a case of undivided retromandibular vein (RV) that was associated with the absence of external jugular vein (EJV). This variation in the jugular venous system was observed on the right side of the neck of a male cadaver. The posterior auricular vein drained into the RV, which joined the facial vein resulting in a common trunk. This common trunk then drained directly into the internal jugular vein (IJV) thus bypassing the whole venous drainage area of the EJV. It is believed that the knowledge about the venous variations, as in the present case, is enlightening to the clinicians. The preoperative evaluation of the venous system is essential to prevent complications like catastrophic bleeding and embolism. The knowledge may guide the emergency physician for a quicker cannulation of the veins.
Double Inferior Vena Cava Associated with Double Suprarenal and Testicular Venous Anomalies: A Rare Case Report
Authors: Khamanarong Kimaporn , Mahiphot Jarupon , Iamsaard Sitthichai 
Published: November 2018

Introduction The variant courses of blood vessels are very important in considerations for retroperitoneal surgeries or interventional radiology. The present study attempted to describe a very rare case of double inferior vena cava (IVC) associated with double left suprarenal veins (LSRVs) and double right testicular veins (RTVs) in a Thai male embalmed cadaver.
Material and Methods A 70-year-old Thai male cadaver was systemically dissected and observed for the vascular distributions during gross anatomy teaching for medical students at the anatomy department of the faculty of medicine of the Khon Kaen University.
Results We found that the double IVCs were connected with the transverse interiliac vein. While the upper LSRV is a tributary of the IVC, the lower LSRV is a tributary of the left renal vein. The RTV bifurcates at about the height of the iliac cristae to form the medial and lateral RTVs, which drain into the right IVC at different heights.
Conclusion All these duplications and associated anomalies are assumed to occur during the embryological development. These anomalies are rare, but the knowledge about the possibilities of these anomalies is of great importance during retroperitoneal surgeries, and during interventional radiology.
Use of Mannose-Binding Lectin Gene Polymorphisms and the Serum MBL Level for the Early Detection of Neonatal Sepsis
Authors: Badawy Magda , Saber Doaa , Madani Hanan , Mosallam Dalia 
Published: November 2018

Background Mannose-binding lectin (MBL) is a component of innate immunity and is particularly important in neonates, in whom adaptive immunity has not yet completely developed. MBL deficiency and MBL2 gene polymorphisms are associated with an opsonization defect and have been associated with neonatal sepsis.
Aim The aim of our study was to assess serum MBL levels and genotype MBL2 genes to determine whether they can serve as markers for predicting neonatal sepsis in neonatal intensive care units.
Patients and Methods A case-control study was conducted with 114 neonates classified into two groups: the septic group included 64 neonates (41 preterm and 23 full-term infants), and the non-septic control group included 50 neonates (29 preterm and 21 full-term infants). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was used to genotype MBL2 gene exon 1 (rs1800450) and (rs1800451) SNPs. Enzyme-linked immunosorbent assay (ELISA) was used to measure MBL serum concentrations.
Results The polymorphic genotypes BB and AC at codons 54 and 57, respectively, showed higher frequencies than the wild-type genotype (AA) (14.1% versus 12.9% and 28.1% versus 19.4% respectively) in both groups, and this difference was greater in the septic group than in the non-septic group; however, the differences did not reach statistical significance. The B and C allele frequencies were also higher in the septic group than in the non-septic group, but the differences did not reach statistical significance (p = 0.282 and 0.394, respectively). The serum levels of MBL were significantly lower in the septic group than in the non-septic group (p = 0.028).
Conclusion This study found no association between MBL levels or MBL2 exon 1 genotypes or alleles and neonatal sepsis risk. Further studies with larger sample sizes are needed to determine the role of the MBL2 gene as a risk factor and early predictor of neonatal sepsis.
Diets containing pomegranate polyphenol and soy isoflavone attenuate contact hypersensitivity in mice
Authors: Nagano Takao , Ito Hideyuki 
Published: November 2018

ABSTRACT
Contact hypersensitivity (CHS) is frequently used as an animal model for human allergic contact dermatitis (ACD). Diets of pomegranate polyphenols (PPs) or soy isoflavones (SIs) each alleviated CHS symptoms; however, the effect of diets containing a mixture of PPs and SIs on CHS is unclear. We investigated the CHS-inhibitory effects of diets supplemented with a mixture of PPs and SIs at human physiologically relevant doses. Consuming the mixture of PPs and SIs attenuated ear swelling and reduced infiltration of Gr-1-positive cells. Ear swelling decreased in the PP and SI-treated mice compared to the SI-treated mice. The auricle tissues of the PP and SI-fed mice exhibited decreased production of CXCL2 and MCP-5 compared to the SI- and PP-treated mice, respectively. These results suggest that dietary supplementation with a mixture of PPs and SIs may have ACD-preventive effects and may prove more beneficial than supplementation with PPs or SIs alone.
A GIS APPROACH TO IDENTIFYING SERVICE ACCESS DISPARITIES IN RURAL APPALACHIA
Authors: Harris A , Savla T , Borowski S , Vipperman A , Roberto K A , Lancki K , Blieszner R , Knight A L 
Published: November 2018

Abstract
Formal service use can help decrease caregiving burden for family members of persons with dementia; however, barriers related to service use are common. For example, driving distance can be problematic in rural areas with mountainous terrain, as in the Appalachian region of Virginia. The purpose of this study was to examine distance from family homes to services and its association with service use. Thirty-nine caregivers’ residences and 84 service locations were mapped, then driving distance to and distribution of services were analyzed using Service Area Solver and Closest Facility Solver in ArcGIS. Results suggest that services were unevenly distributed based on caregiver location. Specifically, of all services examined, food banks and medical facilities had the most facilities near caregiver locations, whereas adult day services, support groups, and educational programs for caregivers were sparse. Findings are discussed in light of identifying vulnerable caregivers as well as hot-spots for potential interventions.
NAT/NCS2-hound: a webserver for the detection and evolutionary classification of prokaryotic and eukaryotic nucleobase-cation symporters of the NAT/NCS2 family
Authors: Chaliotis A , Vlastaridis P , Ntountoumi C , Botou M , Yalelis V , Lazou P , Tatsaki E , Mossialos D , Frillingos S , Amoutzias G D 
Published: November 2018

Abstract
Nucleobase transporters are important for supplying the cell with purines and/or pyrimidines, for controlling the intracellular pool of nucleotides, and for obtaining exogenous nitrogen/carbon sources for metabolism. Nucleobase transporters are also evaluated as potential targets for antimicrobial therapies, since several pathogenic microorganisms rely on purine/pyrimidine salvage from their hosts. The majority of known nucleobase transporters belong to the evolutionarily conserved and ubiquitous nucleobase-ascorbate transporter/nucleobase-cation symporter-2 (NAT/NCS2) protein family. Based on a large-scale phylogenetic analysis that we performed on thousands of prokaryotic proteomes, we developed a webserver that can detect and distinguish this family of transporters from other homologous families that recognize different substrates. We can further categorize these transporters to certain evolutionary groups with distinct substrate preferences. The webserver scans whole proteomes and graphically displays which proteins are identified as NAT/NCS2, to which evolutionary groups and subgroups they belong to, and which conserved motifs they have. For key subgroups and motifs, the server displays annotated information from published crystal-structures and mutational studies pointing to key functional amino acids that may help experts assess the transport capability of the target sequences. The server is 100% accurate in detecting NAT/NCS2 family members. We also used the server to analyze 9,109 prokaryotic proteomes and identified Clostridia, Bacilli, β- and γ-Proteobacteria, Actinobacteria, and Fusobacteria as the taxa with the largest number of NAT/NCS2 transporters per proteome. An analysis of 120 representative eukaryotic proteomes also demonstrates the server's capability of correctly analyzing this major lineage, with plants emerging as the group with the highest number of NAT/NCS2 members per proteome.
Partial Transcondylar Approach for Ventral Foramen Magnum Neurenteric Cyst: 2-Dimensional Operative Video
Authors: Matsushima Ken , Kohno Michihiro , Izawa Hitoshi , Tanaka Yujiro 
Published: November 2018

Abstract
The anterior foramen magnum area, ventral to the brainstem is one of the most difficult regions to access surgically, and the extent of osseous drilling through the far-lateral or transcondylar approach should be planned in each case based on the tumor extension.
1,2
This video, reproduced after informed consent of the patient, demonstrates a case of a ventral foramen magnum neurenteric cyst surgically treated using the partial transcondylar approach. A 27-yr-old woman presented with gait disturbance, oscillopsia, and transient arm numbness. Neuroimaging revealed a ventral foramen magnum cystic tumor involving the basilar and bilateral vertebral arteries. The tumor extended inferiorly from the middle clivus to the C1 level, and occupied the whole premedullary cistern compressing the bilateral lower cranial nerves. The left partial transcondylar approach was performed with drilling the condylar fossa, superior part of the occipital condyle, C1 posterior arch, and posterior part of the jugular process to achieve the sufficient surgical view from the inferolateral side. The drilling of the occipital condyle was minimized so that the articular facet of the occipital condyle was preserved. The tumor on the bilateral side was completely removed as enabled by the sufficient surgical field without new neurological deficits. Three-dimensional reconstructed images based on the postoperative computed tomography scans demonstrated the appropriate extent of the osseous drilling.
Ventral Precentral Fiber Intersection Area: A Central Hub in the Connectivity of Perisylvian Associative Tracts
Authors: Gayoso Sonia , Perez-Borreda Pedro , Gutierrez Antonio , García-Porrero Juan A , Marco de Lucas Enrique , Martino Juan 
Published: November 2018

Abstract

BACKGROUND
The ventral part of the precentral gyrus is considered one of the most eloquent areas. However, little is known about the white matter organization underlying this functional hub.

OBJECTIVE
To analyze the subcortical anatomy underlying the ventral part of the precentral gyrus, ie, the ventral precentral fiber intersection area (VPFIA).

METHODS
Eight human hemispheres from cadavers were dissected, and 8 healthy hemispheres were studied with diffusion tensor imaging tractography. The tracts that terminate at the ventral part of the precentral gyrus were isolated. In addition, 6 surgical cases with left side gliomas close to the VPFIA were operated awake with intraoperative electrical stimulation mapping.

RESULTS
The connections within the VPFIA are anatomically organized along an anteroposterior axis: the pyramidal pathway terminates at the anterior bank of the precentral gyrus, the intermediate part is occupied by the long segment of the arcuate fasciculus, and the posterior bank is occupied by the anterior segment of the arcuate fasciculus. Stimulation of the VPFIA elicited speech arrest in all cases.

CONCLUSION
The present study shows strong arguments to sustain that the fiber organization of the VPFIA is different from the classical descriptions, bringing new light for understanding the functional role of this area in language. The VPFIA is a critical neural epicenter within the perisylvian network that may represent the final common network for speech production, as it is strategically located between the termination of the dorsal stream and the motor output cortex that directly control speech muscles.
Left Transsylvian-Transinsular Approach for Radiation-Induced Cavernous Malformation: 3-Dimensional Operative Video
Authors: Burkhardt Jan-Karl , Gandhi Sirin , Tabani Halima , Benet Arnau , Lawton Michael T 
Published: November 2018

Abstract
De novo cavernous malformation (CM) formation after radiation therapy for brain tumors is well known, but CM formation adjacent to a radiosurgically treated arteriovenous malformation (AVM) is rare.
1
This video demonstrates the microsurgical resection of a de novo CM adjacent to a previously treated high-grade AVM and clipping of a middle cerebral artery (MCA) aneurysm. A 70-yr-old male with history of radiosurgery for AVM presented with aphasia and confusion. Preoperative angiography showed complete occlusion of the AVM. MRI showed multiple cystic lesions suspicious for radiation-induced necrosis and CM.
IRB approval and patient consent was obtained. A pterional craniotomy was performed with transsylvian exposure of the insula. The radiated feeding arteries were followed to the occluded AVM nidus. A CM was noted deep to this candelabra of the MCA vessels, which were mobilized to access and resect the CM. A small incision was made in this insular cortex underneath the malformation circumferentially freeing it of adhesions. The sclerotic AVM nidus was circumferentially dissected and removed en bloc. Thorough exploration of the resection cavity revealed no residual CM or AVM nidus. Attention was then turned to the M2-MCA bifurcation aneurysm, which was occluded with a straight clip. Postoperative imaging confirmed complete CM resection. The patient recovered from his aphasia.
This case demonstrates the management of a radiation-induced de novo CM following treatment of a high-grade AVM. Radiographic follow-up for radiosurgically treated AVM is needed to rule out long-term complications. Bleeding from a de novo CM mimics bleeding from residual AVM nidus, requiring careful angiographic evaluation.