bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Uncommon Approach to the Global Commons: Interpreting China's Divergent Positions on Maritime and Outer Space Governance
Authors: Freeman Carla P. 
Published: June 2019

AbstractThis study assesses China's approach to the global commons, those areas of the globe over which no state exercises sovereignty and that are accessible to all. Examining Chinese behaviour, official statements and expert positions towards the extant high seas and outer space regimes, this research concludes that China approaches the principle of international access to the two domains situationally, reflecting its assessment of how these regimes affect its national interests. The finding cautions against blanket characterizations of China's strategic orientation towards the global commons.
Small parks, big designs: reconstructed Tokyo's new green spaces, 1923–1931
Authors: Borland Janet 
Published: June 2019

AbstractThis article explores the genesis of small parks in Tokyo following the 1923 Great Kantō Earthquake. It sheds new light on an example of innovative urban design and post-disaster reconstruction, and highlights the growing place that children occupied in the minds of bureaucrats and urban planners. The small parks were designed for children first and foremost. Originally conceived as a means to increase space for school children to play and exercise, all 52 parks were strategically located beside primary schools. As the state's goals of social management expanded, however, officials increasingly recognized the potential to use small parks as sites of rest and guided recreation, as well as emergency refuge. A history of Tokyo's small parks thus offers a window in to the growing understanding about the relationship between the built environment, health and society in inter-war Japan.
Vascular endothelial growth factor polymorphism rs2010963 status does not affect patent ductus arteriosus incidence or cyclooxygenase inhibitor treatment success in preterm infants
Authors: Sallmon Hannes , Aydin Tünay , Hort Stefanie , Kubinski Anja , Bode Christina , Klippstein Tamara , Endesfelder Stefanie , Bührer Christoph , Koehne Petra 
Published: June 2019

AbstractBackground:Vascular endothelial growth factor is critically involved in ductus arteriosus closure. Polymorphisms in the vascular endothelial growth factor gene have been associated with several diseases in neonates and adults.Aim:Herein, we investigated if vascular endothelial growth factor polymorphism rs2010963 status is associated with patent ductus arteriosus incidence and/or pharmacological treatment success.Methods:We assessed rs2010963 status in 814 preterm infants (<1500 g birth weight) by means of restriction fragment length polymorphism analysis. DNA samples were obtained from dry-spot cards used for the German national newborn screening program. Clinical data were obtained by retrospective chart review.Results:We could not find any statistically significant difference in the incidence of patent ductus arteriosus depending on vascular endothelial growth factor rs2010963 polymorphism status. Furthermore, no statistically significant associations between vascular endothelial growth factor polymorphism rs2010963 status and cyclooxygenase inhibitor treatment success were observed.Conclusion:Our results indicate that there is no association between vascular endothelial growth factor polymorphism rs2010963 status and the occurrence of patent ductus arteriosus or the response to cyclooxygenase inhibitor treatment in a large cohort of preterm infants. Additional studies are needed to determine the role of genetic factors on patent ductus arteriosus incidence and treatment response.
Long-term results after palliative intra-cardiac repair for tetralogy of Fallot and diminutive pulmonary arteries
Authors: Kawahira Yoichi , Nishigaki Kyoichi , Kagisaki Koji , Watanabe Takuji , Tanimoto Kazuki 
Published: June 2019

AbstractBackground:In patients with tetralogy of Fallot with the diminutive pulmonary arteries, we sometimes have to give up the complete intra-cardiac repair due to insufficient growth of the pulmonary arteries. We have carried out palliative intra-cardiac repair using a fenestrated patch.Methods:Of all 202 patients with tetralogy of Fallot in our centre since 1996, five patients (2.5%) with the diminutive pulmonary arteries underwent palliative intra-cardiac repair using a fenestrated patch. Mean operative age was 1.8 years. Previous operation was Blalock–Taussig shunt in 4. At operation, the ventricular septal defect was closed using a fenestrated patch and the right ventricular outflow tract was enlarged. Follow-up period was 9.8 ± 2.6 years.Results:There were no operative and late deaths. Fenestration closed spontaneously on its own in four patients 2.7 ± 2.1 years after the intra-cardiac repair with a stable haemodynamics; however, the last patient with the smallest pulmonary artery index had supra-systemic pressure of the right ventricle post-operatively. The fenestration was emergently enlarged. Systemic arterial oxygen saturation was significantly and dramatically increased from 83.5 to 94% after the palliative intra-cardiac repair, and to 98% at the long term. A ratio of systolic pressure of the right ventricle to the left was significantly decreased to 0.76 ± 0.12 at the long term. Now all five patients were Ross classification class I.Conclusion:Although frequent catheter and surgical interventions were needed after the palliative intra-cardiac repair, this repair might be a choice improving quality of life with good results in patients with tetralogy of Fallot associated with the diminutive pulmonary arteries.
Substance misuse in later life: challenges for primary care: a review of policy and evidence
Authors: Rao Rahul , Crome Ilana , Crome Peter , Iliffe Steve 
Published: June 2019

AbstractBackgroundSubstance misuse in older people represents a growing clinical and public health problem within primary care.AimThe aim of article is to explore policy and research evidence for informing best practice in the assessment, treatment effectiveness, treatment implementation and approaches to recovery for older people with substance misuse in primary care.MethodsRelevant search terms were used to examine the databases MEDLINE, EMBASE, CINAHL and PsychINFO up to January 2016.ResultsAn age-sensitive approach is required to overcome barriers to assessment. Training is essential for developing relevant knowledge, skills and attitudes. Clinical audit be used to develop care pathways, particularly for older people with dual diagnosis. There is also a need to develop closer links between primary care and the secondary care specialties, as well as added value in working with carers and voluntary agencies.DiscussionFurther research is needed to inform more effective approaches to treatment. Adequate funding for workforce development and quality improvement in service development are also essential to improve health outcomes and quality of life in older people with substance misuse.
Automated policing: the case of body-worn video
Authors: Bowling Ben , Iyer Shruti 
Published: June 2019

AbstractThis paper examines the impact of body-worn video (BWV) on the police craft skills of close observation, note-taking, investigative analysis, report-writing and preparation of evidence for the courts. It explains how the technology functions and explores its surveillant, investigative, probative and regulatory applications. The evidence shows that policing tasks are being transformed by BWV cameras and analytics such as facial recognition. The paper argues that BWV exemplifies the automation of policing – the replacement of police labour with mechanical devices – and explores the implications of this for transparency, accountability, fairness and police discretion.
Electoral incentives for cross-ethnic voting: evidence from a natural experiment
Authors: Stojanović Nenad , Strijbis Oliver 
Published: June 2019

AbstractProspects for democracy in multi-ethnic societies are generally more promising if elections are not mere ethnic censuses, in which people vote predominantly for co-ethnic parties and candidates. But what institutions facilitate or hinder ethnic voting? Unlike past studies, this article explores ethnic voting by conducting a natural experiment (rather than surveys or laboratory experiments). It examines the case of Fribourg, a bilingual (French/German) Swiss canton where elections at different levels of government, within the same electoral district, are held under both majoritarian and proportional systems. Coupled with the high territorial homogeneity of the linguistic groups, this unique setting allows us to conduct a robust empirical analysis of voter behaviour. We find that cross-ethnic voting is significantly more frequent in multi-member majoritarian elections than in list-PR elections or in two-member majoritarian elections. Our results yield qualified support to the centripetalist approach to electoral design in multi-ethnic societies, that favours majoritarian systems, rather than to the consociational school that advocates proportional representation.
Behavioral modeling and digital pre-distortion techniques for RF PAs in a 3 × 3 MIMO system
Authors: Alizadeh Mahmoud , Händel Peter , Rönnow Daniel 
Published: June 2019

AbstractModern telecommunications are moving towards (massive) multi-input multi-output (MIMO) systems in 5th generation (5G) technology, increasing the dimensionality of the systems dramatically. In this paper, the impairments of radio frequency (RF) power amplifiers (PAs) in a 3 × 3 MIMO system are compensated in both the time and the frequency domains. A three-dimensional (3D) time-domain memory polynomial-type model is proposed as an extension of conventional 2D models. Furthermore, a 3D frequency-domain technique is formulated based on the proposed time-domain model to reduce the dimensionality of the model, while preserving the performance in terms of model errors. In the 3D frequency-domain technique, the bandwidth of the system is split into several narrow sub-bands, and the parameters of the model are estimated for each sub-band. This approach requires less computational complexity, and also the procedure of the parameters estimation for each sub-band can be implemented independently. The device-under-test consists of three RF PAs including input and output cross-talk channels. The proposed techniques are evaluated in both behavioral modeling and digital pre-distortion (DPD) perspectives. The experimental results show that the proposed DPD technique can compensate the errors of non-linearity and memory effects in the both time and frequency domains.
Water Vapor in the Asian Summer Monsoon Anticyclone: Comparison of Balloon‐Borne Measurements and ECMWF Data
Authors: Brunamonti S. , Füzér L. , Jorge T. , Poltera Y. , Oelsner P. , Meier S. , Dirksen R. , Naja M. , Fadnavis S. , Karmacharya J. , Wienhold F. G. , Luo B. P. , Wernli H. , Peter T. 
Published: June 2019

AbstractWater vapor (H2O) is the strongest greenhouse gas in our atmosphere. Hence, accurate measurements and a correct representation in global models of H2O in the upper troposphere/lower stratosphere (UTLS) are important for understanding and projecting climate. Here we compare balloon‐borne measurements of UTLS H2O, performed by cryogenic frostpoint hygrometers (CFH) and meteorological radiosondes (Vaisala RS41) during two intensive field campaigns in the Asian summer monsoon anticyclone region, with humidity data from three products of the European Centre for Medium‐range Weather Forecasts (ECMWF): operational analysis and forecast (termed OPERA), ERA‐Interim reanalysis, and the newly released ERA5 reanalysis. Taking CFH as a reference, we show that OPERA and ERA5 provide a more accurate representation of UTLS H2O than ERA‐Interim. In particular, OPERA and ERA5 similarly overestimate H2O mixing ratios by on average 0.7–0.8 ppmv (14–15%) and 0.7–0.9 ppmv (15–17%) at pressures 60–100 hPa, respectively, and both provide a good representation of the observed vertical distribution (including fine structures) and natural variability of UTLS H2O. In contrast, ERA‐Interim underestimates UTLS H2O by 0.6–1.7 ppmv (14–30%), and it fails to capture relevant features of the vertical distribution of UTLS H2O. At pressures (p) lower than 60 hPa, all three ECMWF products are in good agreement with CFH. Humidity measurements by RS41 show an average dry bias of 0.1–0.5 ppmv (3–9%) compared to CFH for 60–100 hPa, and a moist bias increasing with altitude for p < 60 hPa, exceeding 100% for p < 40 hPa.
Global Health Implications of Nutrient Changes in Rice Under High Atmospheric Carbon Dioxide
Authors: Smith M. R. , Myers S. S. 
Published: June 2019

AbstractA growing literature has documented that rising concentrations of carbon dioxide in the atmosphere threaten to reduce the iron, zinc, and protein content of staple food crops including rice, wheat, barley, legumes, maize, and potatoes, potentially creating or worsening global nutritional deficiencies for over a billion people worldwide. A recent study extended these previous nutrient analyses to include B vitamins and showed that, in rice alone, the average loss of major B vitamins (thiamin, riboflavin, and folate) was shown to be 17–30% when grown under higher CO2. Here, we employ the EAR cut‐point method, using estimates of national‐level nutrient supplies and requirements, to estimate how B vitamin dietary adequacy may be affected by the CO2‐induced loss of nutrients from rice only. Furthermore, we use the global burden of disease comparative risk assessment framework to quantify one small portion of the health burden related to rising deficiency: a higher likelihood of neural tube defects for folate‐deficient mothers. We find that, as a result of this effect alone, risk of folate deficiency could rise by 1.5 percentage points (95% confidence interval: 0.6–2.6), corresponding to 132 million (57–239 million) people. Risk of thiamin deficiency could rise by 0.7 points (0.3–1.1) or 67 million people (30–110 million), and riboflavin deficiency by 0.4 points (0.2–0.6) or 40 million people (22–59 million). Because elevated CO2 concentrations are likely to reduce B vitamins in other crops beyond rice, our findings likely represent an underestimate of the impact of anthropogenic CO2 emissions on sufficiency of B vitamin intake.
Radiative Heating of an Ice‐Free Arctic Ocean
Authors: Pistone Kristina , Eisenman Ian , Ramanathan Veerabhadran 
Published: June 2019

AbstractDuring recent decades, there has been dramatic Arctic sea ice retreat. This has reduced the top‐of‐atmosphere albedo, adding more solar energy to the climate system. There is substantial uncertainty regarding how much ice retreat and associated solar heating will occur in the future. This is relevant to future climate projections, including the timescale for reaching global warming stabilization targets. Here we use satellite observations to estimate the amount of solar energy that would be added in the worst‐case scenario of a complete disappearance of Arctic sea ice throughout the sunlit part of the year. Assuming constant cloudiness, we calculate a global radiative heating of 0.71 W/m2 relative to the 1979 baseline state. This is equivalent to the effect of one trillion tons of CO2 emissions. These results suggest that the additional heating due to complete Arctic sea ice loss would hasten global warming by an estimated 25 years.
Extracting Robust Predictors From a Factor Field: An Empirically Optimal Screening Method
Authors: Fan Lei 
Published: June 2019

AbstractExtracting predictors from a predictand‐predictor correlation map is a common problem for climate prediction, but its skill is affected by sampling errors and the subjective selection of predictors; hence, it is difficult to ensure that the selected predictors are optimal. Additionally, cross validation tends to overestimate the actual prediction skill because of artificial skill. In view of these problems, the author proposes an empirically optimal screening (EOS) method to extract predictors from a correlation map. Based on hindcast cross validation, EOS empirically and objectively identifies an optimal correlation threshold for data screening. To mitigate artificial skill, cross validation completely separates the training and testing samples, not only for parameter fitting but also prior predictor selection. By using EOS, researchers avoid subjectively determining predictors directly from correlation maps, and EOS further refines potential predictors before the verification of physical mechanisms.
Interannual Sea Level Variability Along the Southeastern Seaboard of the United States in Relation to the Gyre‐Scale Heat Divergence in the North Atlantic
Authors: Volkov Denis L. , Lee Sang‐Ki , Domingues Ricardo , Zhang Hong , Goes Marlos 
Published: June 2019

AbstractThe low‐amplitude, large‐scale, interannual, and longer‐term sea level changes are linked to the variations of ocean heat and freshwater content and strongly controlled by ocean dynamics. Near the coast, especially in low‐lying and flood‐vulnerable regions, these changes can provide background conditions favorable for the occurrence of extreme sea levels that represent a threat for coastal communities and ecosystems. In this study, we identify a tripole mode of the ocean gyre‐scale sea surface height variability in the North Atlantic and show that this mode is responsible for most of the interannual‐to‐decadal sea surface height changes along the southeast coast of the United States, including the Gulf of Mexico. We also show that these changes are largely driven by the large‐scale heat divergence related to the Atlantic Meridional Overturning Circulation and linked to the low‐frequency North Atlantic Oscillation.
Insights Into Permafrost and Seasonal Active‐Layer Dynamics From Ambient Seismic Noise Monitoring
Authors: James S. R. , Knox H. A. , Abbott R. E. , Panning M. P. , Screaton E. J. 
Published: June 2019

AbstractWidespread permafrost thaw in response to changing climate conditions has the potential to dramatically impact ecosystems, infrastructure, and the global carbon budget. Ambient seismic noise techniques allow passive subsurface monitoring that could provide new insights into permafrost vulnerability and active‐layer processes. Using nearly 2 years of continuous seismic data recorded near Fairbanks, Alaska, we measured relative velocity variations that showed a clear seasonal cycle reflecting active‐layer freeze and thaw. Relative to January 2014, velocities increased up to 3% through late spring, decreased to −8% by late August, and then gradually returned to the initial values by the following winter. Velocities responded rapidly (over ~2 to 7 days) to discrete hydrologic events and temperature forcing and indicated that spring snowmelt and infiltration events from summer rainfall were particularly influential in propagating thaw across the site. Velocity increases during the fall zero‐curtain captured the refreezing process and incremental ice formation. Looking across multiple frequency bands (3–30 Hz), negative relative velocities began at higher frequencies earlier in the summer and then shifted lower when active‐layer thaw deepened, suggesting a potential relationship between frequency and thaw depth; however, this response was dependent on interstation distance. Bayesian tomography returned 2‐D time‐lapse images identifying zones of greatest velocity reduction concentrated in the western side of the array, providing insight into the spatial variability of thaw progression, soil moisture, and drainage. This study demonstrates the potential of passive seismic monitoring as a new tool for studying site‐scale active‐layer and permafrost thaw processes at high temporal and spatial resolution.
Contrasting Temperature Sensitivity of CO2 Exchange in Peatlands of the Hudson Bay Lowlands, Canada
Authors: Helbig M. , Humphreys E. R. , Todd A. 
Published: June 2019

AbstractIt remains uncertain how the net ecosystem CO2 exchange (NEE) of diverse peatlands will respond to warming. Here we compare five years of eddy covariance measurements of NEE and estimates of gross primary productivity and ecosystem respiration between a fen dominated by deciduous vegetation and an adjacent bog with evergreen vegetation in the Canadian Hudson Bay Lowlands. At the bog, daily net CO2 uptake lasted from snowmelt to snow cover onset, while at the fen, net CO2 uptake was delayed in spring and ended earlier in fall. Greater midsummer net CO2 uptake at the fen compensated for shoulder season net CO2 losses resulting in similar annual NEE at the two sites (fen: −52 ± 16 g C m−2, bog: −80 ± 14 g C m−2). Observations of a satellite‐based productivity index also suggest lower shoulder season and higher peak vegetation productivity at these deciduous versus evergreen plant‐dominated peatlands. The response of NEE to warmer weather differed between sites. Warming during the shoulder seasons increased net CO2 uptake at the evergreen plant‐dominated bog, while it increased net CO2 losses at the fen where deciduous leaves had not yet emerged or had senesced. In contrast, warmer weather during the peak growing season appeared to reduce net CO2 uptake more at the bog than the fen resulting from both increasing ecosystem respiration and decreasing gross primary productivity. In the short term, warming will likely decrease annual net CO2 uptake of these and similar peatlands, although the magnitude will depend on factors including vegetation dynamics and seasonality of warming.
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
Authors: Jin Nan , Bi Aiwei , Lan Xiaojing , Xu Jun , Wang Xiaomin , Liu Yingluo , Wang Ting , Tang Shuai , Zeng Hanlin , Chen Ziqi , Tan Minjia , Ai Jing , Xie Hua , Zhang Tao , Liu Dandan , Huang Ruimin , Song Yue , Leung Elaine Lai-Han , Yao Xiaojun , Ding Jian , Geng Meiyu , Lin Shu-Hai , Huang Min 
Published: June 2019

AbstractOne of the biggest hurdles for the development of metabolism-targeted therapies is to identify the responsive tumor subsets. However, the metabolic vulnerabilities for most human cancers remain unclear. Establishing the link between metabolic signatures and the oncogenic alterations of receptor tyrosine kinases (RTK), the most well-defined cancer genotypes, may precisely direct metabolic intervention to a broad patient population. By integrating metabolomics and transcriptomics, we herein show that oncogenic RTK activation causes distinct metabolic preference. Specifically, EGFR activation branches glycolysis to the serine synthesis for nucleotide biosynthesis and redox homeostasis, whereas FGFR activation recycles lactate to fuel oxidative phosphorylation for energy generation. Genetic alterations of EGFR and FGFR stratify the responsive tumors to pharmacological inhibitors that target serine synthesis and lactate fluxes, respectively. Together, this study provides the molecular link between cancer genotypes and metabolic dependency, providing basis for patient stratification in metabolism-targeted therapies.