bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging to lung transplantation with double-lumen venovenous extracorporeal membrane oxygenation
Authors: Yanagida Roh , Seethamraju Harish , Davenport Daniel L , Tribble Thomas A , Zwischenberger Joseph B , Hoopes Charles W 
Published: June 2019

Background: Double-lumen venovenous extracorporeal membrane oxygenation may be used as a bridge to lung transplantation. Predictors of outcome with this strategy have not been well described. Methods: All patients with irreversible lung disease who developed acute pulmonary failure and required double-lumen venovenous extracorporeal membrane oxygenation as a bridge to decision or lung transplant at our institution were included in this study. Survival of the extracorporeal membrane oxygenation patients was compared with listed patients who did not require extracorporeal membrane oxygenation with lung allocation score in the highest 10% for the same period. Results: Fifteen patients (46 ± 17 years old) received double-lumen venovenous extracorporeal membrane oxygenation cannula. Mean length of extracorporeal membrane oxygenation support was 18.2 (1–60) days. Of these, seven patients were bridged to lung transplant, six died on extracorporeal membrane oxygenation, and two weaned to recovery. Amount of red blood cell transfusion was significantly higher (3.3 vs 18.5 U, p = 0.003) and lowest oxygen saturation was significantly lower in non-survivors (84.5% vs 66.3%, p = 0.002). Of the seven patients who were already listed for lung transplant at the onset of extracorporeal membrane oxygenation, five were transplanted. Overall survival to hospital discharge was 60%. Survival of patients with lung allocation score in the highest 10% (average lung allocation score 83.4) in the same period was 80%. Conclusion: Double-lumen venovenous extracorporeal membrane oxygenation cannula is a feasible option to bridge patients to decision or lung transplantation. Blood transfusion requirement and low oxygen saturation are markers of poor prognosis. Listing status at the time of cannulation and ambulation during extracorporeal membrane oxygenation support may be important indicators of good outcome.
Factors influencing adherence to vacuum-formed retainer wear: A qualitative study
Authors: Al-Moghrabi Dalya , Colonio Salazar Fiorella Beatriz , Johal Ama , Fleming Padhraig S 
Published: June 2019

Objective: To explore factors influencing adherence to vacuum-formed retainer wear over a minimum period of four years. Design: A qualitative study based on a randomised controlled trial assessing the effectiveness of orthodontic retainers. Setting: Institute of Dentistry, Queen Mary University of London. Participants: Fifteen participants wearing vacuum-formed retainers for at least four years. Methods: One-to-one semi-structured interviews were undertaken on a criterion-based purposive sample of participants wearing vacuum-formed retainers. The interviews were audio-recorded, transcribed verbatim and analysed using Framework Methodology. Results: High self-reported levels of adherence in the early stages of retention were linked to a desire to maintain orthodontic outcomes and the negative perception of potential post-treatment changes. However, adherence typically reduced over time due to a combination of factors including the negative impact of retainers on quality of life and pragmatic issues related to retainer wear. Network support was found to be important in the short and long term, with instances of self-directed wear and negative beliefs concerning the importance of retainer wear and predisposition to post-treatment changes. Lack of follow-up appointments and immaturity of participants prompted independent decisions to cease retainer wear. Conclusions: Six key influencers of prolonged adherence with vacuum-formed retainer wear were identified. Future strategies to improve adherence should account for these while also being responsive to time elapsed since debond and patient age.
How I treat polycythemia vera
Authors: Spivak Jerry L. 
Published: June 2019

AbstractSince its discovery, polycythemia vera (PV) has challenged clinicians responsible for its diagnosis and management and scientists investigating its pathogenesis. As a clonal hematopoietic stem cell (HSC) disorder, PV is a neoplasm but its driver mutations result in overproduction of morphologically and functionally normal blood cells. PV arises in an HSC but it can present initially as isolated erythrocytosis, leukocytosis, thrombocytosis, or any combination of these together with splenomegaly or myelofibrosis, and it can take years for a true panmyelopathy to appear. PV shares the same JAK2 mutation as essential thrombocytosis and primary myelofibrosis, but erythrocytosis only occurs in PV. However, unlike secondary causes of erythrocytosis, in PV, the plasma volume is frequently expanded, masking the erythrocytosis and making diagnosis difficult if this essential fact is ignored. PV is not a monolithic disorder: female patients deregulate fewer genes and clinically behave differently than their male counterparts, while some PV patients are genetically predisposed to an aggressive clinical course. Nevertheless, based on what we have learned over the past century, most PV patients can lead long and productive lives. In this review, using clinical examples, I describe how I diagnose and manage PV in an evidence-based manner without relying on chemotherapy.
Introduction of the harmonised respiratory physiotherapy curriculum
Authors: Troosters Thierry , Tabin Nathalie , Langer Daniel , Burtin Chris , Chatwin Michelle , Clini Enrico M. , Emtner Margareta , Gosselink Rik , Grant Kathleen , Inal-Ince Deniz , Lewko Agnieszka , Main Eleanor , Mitchell Sharon , Niculescu Alexandra , Oberwaldner Beatrice , Pitta Fabio 
Published: June 2019

Building on the core syllabus for postgraduate training in respiratory physiotherapy, published in 2014, the European Respiratory Society (ERS) respiratory physiotherapy task force has developed a harmonised and structured postgraduate curriculum for respiratory physiotherapy training. The curriculum outlines the knowledge, skills and attitudes which must be mastered by a respiratory physiotherapist working with adult or paediatric patients, together with guidance for minimal clinical exposures, and forms of learning and assessment.This article presents the rationale, methodology and content of the ERS respiratory physiotherapy curriculum. The full curriculum can be found in thesupplementary material.
Treatment outcome of patients with chondroblastic osteosarcoma of the limbs and pelvis
Authors: Tsagozis P. , Laitinen M. K. , Stevenson J. D. , Jeys L. M. , Abudu A. , Parry M. C. 
Published: June 2019

Aims The aim of this study was to identify factors that determine outcomes of treatment for patients with chondroblastic osteosarcomas (COS) of the limbs and pelvis. Patients and Methods The authors carried out a retrospective review of prospectively collected data from 256 patients diagnosed between 1979 and 2015. Of the 256 patients diagnosed with COS of the pelvis and the limbs, 147 patients (57%) were male and 109 patients (43%) were female. The mean age at presentation was 20 years (0 to 90). Results In all, 82% of the patients had a poor response to chemotherapy, which was associated with the presence of a predominantly chondroblastic component (more than 50% of tumour volume). The incidence of local recurrence was 15%. Synchronous or metachronous metastasis was diagnosed in 60% of patients. Overall survival was 51% and 42% after five and ten years, respectively. Limb localization and wide surgical margins were associated with a lower risk of local recurrence after multivariable analysis, while the response to chemotherapy was not. Local recurrence, advanced patient age, pelvic tumours, and large volume negatively influenced survival. Resection of pulmonary metastases was associated with a survival benefit in the limited number of patients in whom this was undertaken. Conclusion COS demonstrates a poor response to chemotherapy and a high incidence of metastases. Wide resection is associated with improved local control and overall survival, while excision of pulmonary metastases is associated with improved survival in selected patients. Cite this article: Bone Joint J 2019;101-B:739–744.
Value of the ‘clicky hip’ in selective screening for developmental dysplasia of the hip
Authors: Marson B. A. , Hunter J. B. , Price K. R. 
Published: June 2019

AimsThe aim of this study was to review the value of accepting referrals for children with ‘clicky hips’ in a selective screening programme for hip dysplasia.Patients and MethodsA single-centre prospective database of all referrals to the hip clinic was examined to identify indication for referrals, diagnosis, and treatment. All patients referred received a standardized ultrasound scan and clinical examination by an orthopaedic consultant.ResultsThere were 5716 children referred to the orthopaedic hip clinic between 1 June 2014 and 26 September 2018. In all, 1754 children (30.1%) were referred due to ‘clicky hip’ with no additional risk factors or indications for ultrasound scan. A total of 123 children (7.1%) referred with ‘clicky hip’ and no additional risk factors or examination findings had an abnormal initial hip ultrasound, including 16 children (0.9%) with dysplastic hips. Of the 141 children who required treatment in a Pavlik harness during the study period, 23 (16%) had been referred with a ‘clicky hip’ and no additional risk factors or examination findings, including six children with Graf 3 or 4 hips.ConclusionThere is significant value in reviewing children with an isolated ‘clicky hip’. Many children who require treatment are referred to the orthopaedic service as ‘clicky hip’ with no additional risk factors. In a pragmatic pathway with a diverse population of clinicians performing baby checks, ‘clicky hip’ is an important indication for referral and should not be discarded. Cite this article: Bone Joint J 2019;101-B:635–638.
Congenital talipes equinovarus
Authors: Gelfer Y. , Wientroub S. , Hughes K. , Fontalis A. , Eastwood D. M. 
Published: June 2019

Aims The Ponseti method is the benchmark treatment for the correction of clubfoot. The primary rate of correction is very high, but outcome further down the treatment pathway is less predictable. Several methods of assessing severity at presentation have been reported. Classification later in the course of treatment is more challenging. This systematic review considers the outcome of the Ponseti method in terms of relapse and determines how clubfoot is assessed at presentation, correction, and relapse. Patients and Methods A prospectively registered systematic review was carried out according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies that reported idiopathic clubfoot treated by the Ponseti method between 1 January 2012 and 31 May 2017 were included. The data extracted included demographics, Ponseti methodology, assessment methods, and rates of relapse and surgery. Results A total of 84 studies were included (7335 patients, 10 535 clubfeet). The relapse rate varied between 1.9% and 45%. The rates of relapse and major surgery (1.4% to 53.3%) and minor surgery (0.6% to 48.8%) both increased with follow-up time. There was high variability in the assessment methods used across timepoints; only 57% of the studies defined relapse. Pirani scoring was the method most often used. Conclusion Recurrence and further surgical intervention in idiopathic clubfoot increases with the duration of follow-up. The corrected and the relapsed foot are poorly defined, which contributes to variability in outcome. The results suggest that a consensus for a definition of relapse is needed. Cite this article: Bone Joint J 2019;101-B:639–645.
A dedicated revision total knee service
Authors: Gabor J. A. , Padilla J. A. , Feng J. E. , Anoushiravani A. A. , Slover J. , Schwarzkopf R. 
Published: June 2019

Aims Revision total knee arthroplasty (rTKA) accounts for approximately 5% to 10% of all TKAs. Although the complexity of these procedures is well recognized, few investigators have evaluated the cost and value-added with the implementation of a dedicated revision arthroplasty service. The aim of the present study is to compare and contrast surgeon productivity in several differing models of activity. Materials and Methods All patients that underwent primary or revision TKA from January 2016 to June 2018 were included as the primary source of data. All rTKA patients were categorized by the number of components revised (e.g. liner exchange, two or more components). Three models were used to assess the potential surgical productivity of a dedicated rTKA service : 1) work relative value unit (RVU) versus mean surgical time; 2) primary TKA with a single operating theatre (OT) versus rTKA with a single OT; and 3) primary TKA with two OTs versus rTKA with a single OT. Results In total, 4570 procedures were performed: 4128 primary TKAs, 51 TKA liner exchanges, and 391 full rTKAs. Surgical time was significantly different between the primary TKA, liner exchange, and rTKA cohorts (100.6, 97.1, and 141.7 minutes, respectively; p < 0.001). Primary TKA yielded a mean of 7.1% more RVU/min per procedure than rTKA. Our one-OT model demonstrated that primary TKA (n = 4) had a 1.9% RVU/day advantage over rTKA (n = 3). If two OTs are used for primary TKA (n = 6), the outcome strongly favours primary TKA by an added 34.6% RVUs/day. Conclusion Our results suggest that a dedicated rTKA service would lead to lower surgeon remuneration based on the current RVU paradigm. Revision arthroplasty specialists may need additional or alternative incentives to promote the development of a dedicated revision service. Through such an approach, healthcare organizations could enhance the quality of care provided, but surgeon productivity measures would need to be adjusted to reflect the burden of these cases. Cite this article: Bone Joint J 2019;101-B:675–681.
Validation of a prospective cohort study of older adults with hip fractures
Authors: Metcalfe D. , Costa M. L. , Parsons N. R. , Achten J. , Masters J. , Png M. E. , Lamb S. E. , Griffin X. L. 
Published: June 2019

Aims This study sought to determine the proportion of older adults with hip fractures captured by a multicentre prospective cohort, the World Hip Trauma Evaluation (WHiTE), whether there was evidence of selection bias during WHiTE recruitment, and the extent to which the WHiTE cohort is representative of the broader population of older adults with hip fractures. Patients and Methods The characteristics of patients recruited into the WHiTE cohort study were compared with those treated at WHiTE hospitals during the same timeframe and submitted to the National Hip Fracture Database (NHFD). Results Patients recruited to WHiTE were more likely to be admitted from their own home (83.5% vs 80.2%; p < 0.001) and to have a higher median Abbreviated Mental Test Score (AMTS) (9 (interquartile range (IQR) 6 to 10) vs 9 (IQR 5 to 10); p < 0.001) than those who were not recruited. In terms of WHiTE cohort generalizability, participating hospitals included a greater proportion of Major Trauma Centres (47.8% vs 7.8%) and large hospitals (997 (IQR 873 to 1290) vs 707 (459 to 903) beds) with high-volume Emergency Departments (median annual attendances of 43 981 (IQR 37 147 to 54 385) vs 35 964 (IQR 26 229 to 50 551)). However, there were few differences in baseline characteristics between patients in the WHiTE cohort and those recorded in the NHFD. Conclusion There is evidence of a weak selection bias towards recruiting fitter patients within the WHiTE cohort, which will help to put into context the findings of future studies. We conclude that the patients within the WHiTE cohort are representative of the national population of older adults with hip fractures throughout England, Wales, and Northern Ireland. Cite this article: Bone Joint J 2019;101-B:708–714.
Territorios en disputa: Modernidad, figuración urbana y recepción de la reescritura fílmica de Los de la mesa 10
Authors: Sala Jorge 
Published: June 2019

El artículo analiza la traslación al cine de Los de la mesa 10 (Feldman, 1960), basada en la obra teatral de Osvaldo Dragún. El paper aborda esta relación a través de cuatro ejes: la coincidencia de intereses entre el director y el dramaturgo basada en la obtención de una consagración horizontal; el acercamiento del film a los parámetros de la modernidad a través del trabajo sobre la puesta en escena; la representación de la ciudad y la inclusión de espacios reconocibles; y el rol jugado por los críticos al momento de dar a conocer la propuesta y el enfrentamiento que mantuvieron con el campo de poder. El enfoque metodológico elegido busca reconstruir los hechos desde una perspectiva doble: prestando atención tanto a los aspectos internos como a sus condiciones de producción y al contexto en el cual se dio a conocer la propuesta y a las reacciones generada entre los receptores especializados.
The article analyses the translation to cinema of Los de la mesa 10 (Feldman, 1960), based on Osvaldo Dragún’s play. The article addresses this relationship through four axes: the coincidental interests between the director and the autor based on obtaining a horizontal consecration; the filmic approach to the parameters of modernity through staging decisions; the representation of the city and the inclusion of recognizable spaces; and the role played by the critics at the time of making known the proposal and the confrontation that they maintained with the power field. The chosen methodological approach seeks to reconstruct the facts from a double perspective: presenting attention to both the internal aspects and their production conditions and the context in which the proposal was made known and the reactions generated among the specialized receivers.
The Association among Corporate Governance, Corruption, and Economic Prosperity in the Socialist Republic of Vietnam
Authors: Gros Marius , Henke Tobias 
Published: June 2019

AbstractThe OECD considers compliance with the OECD principles of corporate governance and reduced corruption to be positively associated with economic prosperity. Prior empirical research supports this notion for developed countries. However, findings for developing and emerging countries are more diverse, as some studies document an “East Asia paradox” and link higher levels of corruption with positive outcomes at the firm or country level. Our case study on the Socialist Republic of Vietnam contributes to the literature by identifying determinants of these mixed findings. Relying on triangulation, our results suggest that internationalizing and international firms must adhere to OECD expectations to prosper, while domestic firms prefer operating in corrupt but stable conditions. Due to this mechanism, noncompliance with OECD principles and corruption can deter foreign direct investments and thus negatively influence economic growth. Nevertheless, noncompliance with OECD principles and corruption can still work to benefit domestic firms. Given our results for Vietnam, we argue that the internationalization of the business models of the firms analyzed might explain the prior inconclusive empirical findings.
Suicidal ideation and suicide attempt among Indonesian adolescent students
Authors: Putra I Gusti Ngurah Edi , Karin Putu Ayu Emmy Savitri , Ariastuti Ni Luh Putu 
Published: June 2019

AbstractSuicide among young people is growing as a public health threat worldwide. With a paucity of studies on this issue in Indonesia, this study aimed to identify factors associated with suicidal behaviors (suicidal ideation and suicide attempt) among Indonesian adolescents. This was a cross-sectional study using secondary data analysis from the Global School-based Student Health Survey (GSHS) of Indonesia in 2015. The samples were 8634 school-going adolescents aged 13–18 years old. The data analysis consisted of univariate, bivariate and multivariate analysis. The chi-square (χ2) test was employed to identify proportion differences of suicidal behaviors by independent variables whereas multiple logistic regression was used to develop models for factors associated with suicidal ideation and suicide attempt. This study found that 4.75% and 2.46% reported for having suicidal ideation and suicide attempt in the last 12 months, respectively. The effects of intrapersonal factors (sex, age, loneliness, anxiety, current use of tobacco and alcohol) and interpersonal factors (physically attacked, bullying victimization, having no close friends, parental understanding and having sexual intercourse) varied by suicidal behavior and sex. Therefore, developing comprehensive approaches for prevention of mental health problems, including suicidal behaviors in the school setting is essential by asking for a collaboration of schools, parents, public health centers (PHCs), related stakeholders and non-governmental organizations (NGOs).
Determination and verification of reference interval limits in clinical chemistry. Recommendations for laboratories on behalf of the Working Group Guide Limits of the DGKL with respect to ISO Standard 15189 and the Guideline of the German Medical Association on Quality Assurance in Medical Laboratory Examinations (Rili-BAEK)
Authors: Özcürümez Mustafa K. , Haeckel Rainer , Gurr Eberhard , Streichert Thomas , Sack Ulrich 
Published: June 2019

AbstractLaboratory measurement values require interpretative assistance e.g. so-called guide limits (GL), as an interpretative aid. Legal and normative requirements for medical laboratories do not provide specific information for their implementation and verification. A German Society for Clinical Chemistry and Laboratory Medicine (DGKL) Working Group GL (WG-GL) has, therefore, developed recommendations to support medical laboratories in the management of GL. A specific objective was to create a framework that mainly takes into account those aspects that can be realistically implemented by routine laboratories and that should improve the management of GL of frequently requested quantitative measurement procedures in clinical chemistry. Thus, the focus of these recommendations is on the distinction between reference interval limits and clinical decision limits as well as the determination and verification of reference interval limits. Indirect approaches are highlighted, as they enable routine laboratories with a broad analytical spectrum but limited resources to evaluate or to establish reference limits.
Pentavalent arc-transitive Cayley graphs on Frobenius groups with soluble vertex stabilizer
Authors: Liu Hailin 
Published: June 2019

Abstract
A Cayley graph Γ is said to be arc-transitive if its full automorphism group AutΓ is transitive on the arc set of Γ. In this paper we give a characterization of pentavalent arc-transitive Cayley graphs on a class of Frobenius groups with soluble vertex stabilizer.
On Diophantine approximation by unlike powers of primes
Authors: Ge Wenxu , Li Weiping , Wang Tianze 
Published: June 2019

Abstract
Suppose that λ1, λ2, λ3, λ4, λ5 are nonzero real numbers, not all of the same sign, λ1/λ2 is irrational, λ2/λ4 and λ3/λ5 are rational. Let η real, and ε > 0. Then there are infinitely many solutions in primes pj to the inequality
$\begin{array}{}
\displaystyle
|\lambda_1p_1+\lambda_2p_2^2+\lambda_3p_3^3+\lambda_4p_4^4+\lambda_5p_5^5+\eta| \lt (\max{p_j^j})^{-1/32+\varepsilon}
\end{array}$. This improves an earlier result under extra conditions of λj.