bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of sling exercise training on motor function in children with cerebral palsy: A systematic review and meta-analysis
Authors: Liu Yu’ang , Zhang Xinxin , Zhang Zhi , Liu Weiguo , Huang Silang , Liao Huangying 
Published: October 2024

Background:
To systematically evaluate the efficacy of sling exercise training on balance and gross motor movement in children with cerebral palsy, and to investigate the effects of different intervention times and ages on treatment outcomes.

Methods:
Randomized controlled trials on sling exercise training for children with cerebral palsy published in full text from CNKI, Wanfang datebase, PubMed, Cochrane Library, Web of Science, and Scopus were searched from the time of build to November 2023. Literature screening, data extraction, and quality assessment were performed independently by 2 researchers, and Meta-analysis was performed using RevMan5.4 and Stata17.0 software.

Results:
A total of 12 studies with 725 patients were included sling exercise training significantly improved balance (I
2 = 0%, mean difference [MD] = 3.42, 95% CI: 2.93–3.92, P < .00001), gross motor function (I
2 = 0%, MD = 5.90, 95% CI: 1.50–10.29, P < .00001), standing function (I
2 = 14%, MD = 2.73, 95% CI: 2.17–3.29, P < .00001) walking and running and jumping function(I
2 = 79%, MD = 5.93, 95% CI: 3.82–8.04, P < .00001) and 10-meter maximum walking speed(I
2 = 58%, MD = 1.47, 95% CI: 0.52–2.42, P = .003) in children with cerebral palsy. Subgroup analyses of balance showed that children in the 5 + age group (I
2 = 0%, MD = 3.73, 95% CI: 2.55–4.91, P < .00001) had better outcomes relative to the 4–5 year old group (I
2 = 23%, MD = 3.49, 95% CI: 2.88–4.09, P<0.00001) and the under 4 year old group (I
2 = 0%, MD = 282.73, 95% CI: 1.57–4.06, P < .00001). Subgroup analyses of walking and running and jumping function showed that a 6-month treatment course(I
2 = 0%, MD = 5.93, 95% CI: 3.82–8.04, P < .00001) had better efficacy relative to a 3-month treatment course(I
2 = 0%, MD = 4.11, 95% CI: 2.84–5.39, P < .00001).

Conclusion:
Sling exercise training significantly improves balance and gross motor function in children with cerebral palsy, and The average age of 5+ years is a critical period for the development of balance in children with cerebral palsy, and the treatment course is an important factor affecting walking and running and jumping function.
A case report on the choice of venous access after ectopic peripherally inserted central catheter in an upper limb of a patient with a second recurrence of right-side breast cancer
Authors: Tian Tian , Tan Lin , Deng Hongyi , Lu Yi 
Published: October 2024

Rationale:
Intravenous catheter placement in the healthy upper extremity is preferred for chemotherapy in patients with breast cancer. Common venous accesses are peripherally inserted central catheters (PICCs) and totally implantable intravenous port catheters (TIVPs). In this case, a patient with breast cancer had a history of infusion port placement through the left internal jugular vein, with ipsilateral innominate vein stenosis after placement. The patient was re-treated with a PICC placed ectopically through the left upper limb into the intrathoracic vein. After multidisciplinary consultation, a transfemoral PICC combined with intracavitary electrocardiography (IC-ECG) was performed to establish venous access. This case can assist PICC catheterization nurses in developing optimal venous access strategies tailored to the specific situations of patients in similar situations. Through adequate evaluations and optimal selection of venous access, the success rate of disposable catheterization can be improved, and the risk of complications reduced.

Patient concerns:
A 53-year-old female with breast cancer had a history of infusion port, with ipsilateral innominate vein stenosis after placement. The patient was re-treated with a PICC placed ectopically through the left upper limb into the intrathoracic vein.

Diagnoses:
An axial computed tomography (CT) image before totally implantable venous access port (TIVP) placement and An axial CT 103 days after TIVP placement shows diffuse stenosis of the left innominate vein, associated with infusion port placement through the left internal jugular vein.

Interventions:
After multidisciplinary consultation, a transfemoral PICC combined with intracavitary electrocardiography (IC-ECG) was performed to establish venous access.

Outcomes:
The patient’s lower limb PICC was left in place for 201 days with no complications, completing the full treatment cycle.

Lessons:
This case presents a rare and insightful clinical scenario. For patients with a history of infusion port placement, particularly via the left internal jugular vein, careful analysis of the innominate vena cava and examination of chest wall vein exposure are essential to determining the optimal vascular access strategy.
Cytologic features of gastric-type endocervical adenocarcinoma: Three cases report and literature review
Authors: Liu Anchun , Yang Maiqing , Zou Hao , Gong Xiaolin , Zeng Chang 
Published: October 2024

Rationale:
Cervical gastric-type adenocarcinoma shows gastric differentiation, and the tumor cell morphology appears benign and unrelated to human papillomavirus, which makes cervical gastric-type adenocarcinoma highly susceptible to misdiagnosis as normal glandular epithelium in cytologic diagnosis.

Patient concerns:
We present 3 cases of gastric-type adenocarcinoma, with the first being a 57-year-old female with abnormal uterine bleeding and fluid drainage. The second patient was a 63-year-old female, and the third was a 59-year-old female with irregular vaginal bleeding after menopause.

Diagnosis:
The 3 patients were diagnosed with cervical gastric-type adenocarcinoma by combining their history, clinical data, cytopathology, histopathology, and immunohistochemistry.

Interventions:
Patient 1 underwent total hysterectomy and adnexectomy, but refused radiotherapy and chemotherapy. Patient 2 received a chemotherapeutic regimen, and patient 3 was treated with traditional Chinese medicine.

Outcomes:
Patient 1 was followed-up for 9 months and is currently in good general condition, while patients 2 and 3 were not followed-up.

Lessons:
The “drunken honeycomb” cell arrangement is diagnostically important in liquid-based cytology, especially when three-dimensional spheroids are present, and may be a characteristic cytological finding of well-differentiated cervical gastric-type adenocarcinoma.
Spontaneous rectus sheath hematoma complicated by deep venous thrombosis: A case report
Authors: Cheruiyot Isaac , Sehmi Prabjot , Kipkorir Vincent , Munguti Jeremiah , Ogeng’o Julius 
Published: October 2024

Rationale:
Rectus sheath hematoma (RSH) is an unusual cause of acute abdominal pain. It is more common in elderly patients on anticoagulation. The diagnosis is often challenging, as it mimics other more common causes of acute abdomen. No standard treatment guidelines exist, presenting therapeutic dilemmas. Herein, we describe a case of spontaneous RSH complicated by deep venous thrombosis (DVT).

Patient concerns:
The patient was a 58-year-old female on follow-up for end-stage renal failure, admitted for management of uremic gastritis, fluid overload state, and bronchopneumonia. On the third day of admission, she developed worsening abdominal pains, associated with dizziness, headaches, hypotension, tachycardia, and desaturation. Abdominal examination revealed tender swelling, with localized guarding.

Diagnoses:
An urgent abdominal computed tomography scan demonstrated a large complex collection of approximately 12 cm × 10 cm in the left rectus sheath with intraperitoneal extension, consistent with RSH.

Interventions:
She underwent laparotomy with evacuation of 1.5 L of hematoma. Her postoperative recovery was complicated by the development of DVT on the sixth postoperative day. Due risk of rebleed, the inferior vena cava filter was favored over therapeutic anticoagulation. Her postoperative hospital stay was thereafter unremarkable.

Outcomes and lessons:
Although rare, RSH is a potential cause of acute abdomen, particularly among patients on anticoagulation, and can be life-threatening. A high index of suspicion is therefore important for early diagnosis. Clinicians should also appreciate the heightened risk of DVT in the immediate postoperative period despite mechanical anticoagulation.
Cronkhite-Canada syndrome: A case report and literature review
Authors: Wang Nanping , Xiang Yue , Tao Liping , Ming Wen , Ren Lijun , Huang Tao , Yang GuoDong , Gao Jian , Ren Quan , Zhu Peng , Huang Min 
Published: October 2024

Rationale:
Cronkhite-Canada syndrome (CCS) is a nonhereditary, rare polyposis condition, first documented by Cronkhite and Canada in 1955. The primary distinct features of this syndrome include ectodermal abnormalities and diffuse gastrointestinal polyp changes accompanied by protein loss. The primary clinical manifestations of CCS include hair loss, excessive pigmentation of the skin, and malnourishment of fingernails or toenails. Other notable symptoms include weight loss, protein-losing enteropathy, diarrhea, abdominal pain, nausea, vomiting, taste abnormalities, and atrophic glossitis, which predominantly occur in middle-aged and older males. CCS is characterized by an extremely rare, nonfamilial hamartomatous polyposis syndrome, in which polyps are distributed in the stomach and colon (90%), small intestine(80%), and rectum (67%), while sparing the esophagus.

Patient concerns:
This report describes a 72-year-old female, initially treated for intestinal obstruction, followed by a small intestine resection. She reported diarrhea, emaciation, and loss of appetite across various hospitals.

Diagnoses:
Endoscopic examination of the stomach and colon, plus capsule endoscopy, revealed multiple polyps throughout her gastrointestinal tract, except in the esophagus.

Interventions:
Treatment included hormones with antiallergic medication, acid-suppressing drugs, salicylates, and nutritional support with zinc sulfate, adding trace elements and amino acids.

Outcomes:
posttreatment, the patient demonstrated significant improvement in appetite and taste. Atrophic glossitis, upper limb pigmentation, and frequency of diarrhea also notably decreased. reexamination through endoscopy after 3 months of treatment revealed a substantial decrease in the number and size of gastrointestinal polyps.

Lessons:
In this case, from the lower esophageal sphincter to the rectum, there is an increasing trend of eosinophil and mast cell infiltration. These lesions can cause a positive IgG result. Pathological analysis indicates that the extent and severity of lesions in the middle and lower gastrointestinal tract are more substantial than in the upper tract. During treatment, endoscopic observations reveal that lesions in the middle and lower tract tend to resolve faster than those in the upper tract. Hormone therapy has demonstrated significant efficacy in treating this disease. Early treatment and regular follow-up for this disease can reduce the risk of cancerous changes and related complications.
A rare case report of concurrent cryptococcal, streptococcal, and tuberculous meningitis in a patient with pulmonary tuberculosis
Authors: Bi Dewu , Luo Xiaolu , Tang Xike , Luo Xiaocheng , Mo Lida 
Published: October 2024

Rationale:
Meningitis caused by concurrent infections with Cryptococcus neoformans, Streptococcus equi subsp. equi, and Mycobacterium tuberculosis is extremely rare.

Patient concerns:
We present the case of a 63-year-old male patient who presented with headaches, dizziness, nausea, vomiting, and fever for the past 3 weeks.

Diagnoses:
The patient was diagnosed with concurrent cryptococcal, streptococcal, and tuberculous meningitis.

Interventions:
The patient received isoniazid, rifampicin, ethambutol, and levofloxacin for 1 month, in addition to liposomal amphotericin B with flucytosine for 2 weeks, followed by fluconazole with flucytosine for additional 2 weeks.

Outcomes:
The symptoms improved, and outpatient therapy was continued.

Lessons:
Infectious meningitis requires a combination of microscopy, culture, and rapid molecular diagnostics for early diagnosis and treatment.
Comparative efficacy of erector spinae plane and quadratus lumborum blocks in managing postoperative pain for total abdominal hysterectomy: A randomized controlled trial
Authors: Baran Onur , Şahin Ayhan , Arar Cavidan 
Published: October 2024

Background:
Effective postoperative pain management after total abdominal hysterectomy is crucial for patient recovery and satisfaction. This study compared the efficacy of the erector spinae plane block (ESPB) and quadratus lumborum block (QLB) in reducing postoperative opioid consumption and pain in patients with total abdominal hysterectomy.

Methods:
In this prospective, randomized controlled trial, 90 patients undergoing total abdominal hysterectomy were divided into 3 groups: ESPB, QLB, and control. The primary outcome was postoperative opioid consumption. Secondary outcomes included pain scores assessed by the visual analog scale at predetermined times and the incidence of postoperative nausea and vomiting. Statistical significance was determined using analysis of variance, the Mann–Whitney U test, and the Kruskal–Wallis test.

Results:
The ESPB and QLB groups showed a significant reduction in postoperative opioid consumption compared with the control group (P < .001 for both comparisons). Pain scores were significantly lower in the ESPB and QLB groups than in the control group at 2, 6, and 24 hours postoperatively (P < .001 at each time point). The incidence of postoperative nausea and vomiting was lower in the ESPB and QLB groups than that in the control group; however, this difference was not statistically significant (P = .029). No significant differences were observed in opioid consumption or pain scores between the 2 groups.

Conclusion:
Both the erector spinae plane and quadratus lumborum blocks effectively reduced postoperative opioid consumption and pain in patients with total abdominal hysterectomy. These techniques offer a promising approach for postoperative pain management, potentially reducing the need for opioids.
Association Between Adverse Childhood Experiences and Cognitive Decline
Authors: Chaudhari Gaurav , Vora Darshini , Trivedi Chintan , Reddy Preetam , Bodicherla Krishna Priya , Adnan Mahwish , Vadukapuram Ramu , Kodi Priya Durga , Shah Kaushal , Patel Sruti , Mansuri Zeeshan , Jain Shailesh 
Published: October 2024

Abstract
We aim to study Adverse childhood experiences' (ACEs') association with cognitive decline during adulthood. We reviewed data on subjective cognitive decline (SCD) for those ≥45 years of age. Logistic regression analysis, odds ratio, and 95% confidence interval (CI) assessed the association between ACEs and SCD. We analyzed an adult survey (N = 3900, mean age: 60.9 years, male: 46%). The most common ACE reported was household substance abuse (22.4%), followed by parental divorce/separation (20.9%). The prevalence of SCD in those having at least one ACE was higher than those without any (16.5% vs. 8.1%, p < 0.001). SCD positively correlated with the number of ACEs (p < 0.001). The odds of SCD increase in proportion to the increase in the number of ACEs experienced. These findings should be replicated in a larger population while controlling for confounding factors.
Obstetric Anal Sphincter Injury and Female Sexual Dysfunction: A Systematic Review
Authors: Jericevic Schwartz Dora , Cervantes Isabella , Nwaba A. U. Amanda , Duarte Thibault Mary , Siddique Moiuri 
Published: October 2024

Importance
This is the first systematic review on female sexual dysfunction (FSD) in patients who sustained obstetric anal sphincter injury (OASI).

Objective
The aim of the study was to characterize FSD following OASI.

Study Design
Between January and April 2024, we conducted a literature search of studies that explored outcomes of FSD following OASI, reporting on rates of dyspareunia and/or using questionnaires that measured female sexual function.

Results
Fourteen studies with 1,907 OASI patients met inclusion criteria. Rates of dyspareunia in the first year after OASI ranged from 27% to 35% with only 40%–57% of women having resumed sexual activity at 3 months postpartum. The Female Sexual Function Index (FSFI) and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12) were the most utilized questionnaires. Using the FSFI, the range of FSD was 47%–81% among patients with OASI. The FSFI subdomain scores (maximum 6) for desire and arousal had the least improvement with time, ranging from 1.3–2.1 at 2 months to 3–3.1 at 4 months. Pain, lubrication, and orgasm domains showed greater improvement with time, ranging from 1.4–1.6 at 2 months and up to 3.5–3.8 at 4 months. Five studies used the PISQ-12 with mean scores of 34.1–39 (range 0–48), 3 of which included a non-OASI control group and found similar PISQ-12 scores between groups. Physical therapy did not significantly impact FSD.

Conclusions
One-third of patients with OASI experience dyspareunia in the first year postpartum, 1in 2 patients do not resume intercourse at 3 months postpartum, and FSD, measured by the FSFI, may be present in 80% of women with OASI at 3 months postpartum.
Resistance to Carcinogenesis in the African Spiny Mouse (Acomys) correlates with upregulation of tumor suppressor genes
Authors: Vitorino Marta , Pinheiro Gonçalo G. , Araujo Ines M. , Ferreira Bibiana I. , Link Wolfgang , Tiscornia Gustavo 
Published: October 2024

AbstractCancer remains a leading cause of morbidity and mortality worldwide, driving extensive research into the mechanisms that contribute to its development and progression. The search for animal models capable of shedding light on mechanisms of cancer resistance has led researchers to explore various rodent species. Among these, the African Spiny Mouse (Acomys sp.)has attracted considerable attention due to its regenerative abilities. In our study, we compared the response ofMus musculusandAcomys dimidiatusmice to treatment with the carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) combined with the inducer of proliferation 12-O-tetradecanoylphorbol-13-acetate (TPA). While bothAcomysandMusmice experienced carcinogenic damage to their skin cells, mounted proliferative responses and underwent immune cell infiltration, onlyMusmice developed tumors, whereasAcomysremained tumor-free. To uncover the molecular mechanisms underlying this resistance, we performed RNA sequencing on tissue samples from both species at baseline and at multiple time points during the carcinogenesis protocol. The data reveal distinctly different transcriptional responses between both species. In particular,Acomysshowed massive upregulation of immune related genes, including a set of tumor suppressor genes, whileMusseemed to focus its response on modifying epidermis structure and regulation of the cell cycle. These differences correlated with an increased apoptotic response inAcomysbut notMus. In summary, our study provides compelling evidence thatAcomysmice exhibit remarkable resistance to tumor development under DMBA/TPA carcinogen treatment mediated through the upregulation of a range of processes related to immune surveillance.
Investigation of a Pathogenic Inversion inUNC13Dand Comprehensive Analysis of Chromosomal Inversions Across Diverse Datasets
Authors: Bozkurt-Yozgatli Tugce , Lun Ming Yin , Bengtsson Jesse D. , Sezerman Ugur , Chinn Ivan K. , Coban-Akdemir Zeynep , Carvalho Claudia M.B. 
Published: October 2024

ABSTRACTInversions are known contributors to the pathogenesis of genetic diseases. Identifying inversions poses significant challenges, making it one of the most demanding structural variants (SVs) to detect and interpret. Recent advancements in sequencing technologies and the development of publicly available SV datasets have substantially enhanced our capability to explore inversions. However, a cross-comparison in those datasets remains unexplored. In this study, we reported a proband with familial hemophagocytic lymphohistiocytosis type-3 carrying c.1389+1G>Ain transwith NC_000017.11:75576992_75829587inv disruptingUNC13D, an inversion present in 0.006345% of individuals in gnomAD(v4.0). Based on this result, we investigate the features of potentially pathogenic inversions in public datasets. 98.9% of inversions are rare in gnomAD, and they disrupt 5% of protein-coding genes associated with a phenotype in OMIM. We then conducted a comparative analysis of the datasets, including gnomAD, DGV, and 1KGP, and two recent studies from the Human Genome Structural Variation Consortium revealed common and dataset-specific inversion characteristics suggesting methodology detection biases. Next, we investigated the genetic features of inversions disrupting the protein-coding genes by classifying the intersections between them into three categories. We found that most of the protein-coding genes in OMIM disrupted by inversions are associated with autosomal recessive phenotypes regardless of categories supporting the hypothesis that inversions in trans with other variants are hidden causes of monogenic diseases. This effort aims to fill the gap in our understanding of the molecular characteristics of inversions with low frequency in the population and highlight the importance of identifying them in rare disease studies.
Ultrametric Fredholm operators and approximate pseudospectrum
Authors: Ettayb Jawad 
Published: October 2024

PurposeThe paper deals with ultrametric bounded Fredholm operators and approximate pseudospectra of closed and densely defined (resp. bounded) linear operators on ultrametric Banach spaces.Design/methodology/approachThe author used the notions of ultrametric bounded Fredholm operators and approximate pseudospectra of operators.FindingsThe author established some results on ultrametric bounded Fredholm operators and approximate pseudospectra of closed and densely defined (resp. bounded) linear operators on ultrametric Banach spaces.Originality/valueThe results of the present manuscript are original.
Implied volatility modeling and forecasting: evidence from China
Authors: Jiao Yuhan , Guo Shuxin , Liu Qiang 
Published: October 2024

PurposeTesting several approaches for implied volatility modeling and forecasting.Design/methodology/approachComparative empirical study with four traded options.FindingsNon-parametric higher-order spline is better than parametric stochastic volatility inspired (SVI) in China.Research limitations/implicationsOur results imply that even though popular on Wall Street, SVI seems not to be utilized by traders and market-makers in China.Practical implicationsTraders may consider higher-order spline as a better method for implied volatility modeling and forecasting.Originality/valuePropose to model and forecast implied volatility via the fifth-order spline interpolation as a first; initiates studies of the empirical performance of SVI and the fifth-order spline models in implied volatility modeling and forecasting.