bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical Concordance of Diverse Point-of-Care and Central Laboratory Troponin I Assays
Authors: Tsui Albert K Y , Lyon Martha E , van Diepen Sean , Goudreau Bobbi Lynn , Thomas Dylan , Higgins Trefor , Raizman Joshua E , Füzéry Anna K , Rodriguez-Capote Karina , Estey Mathew , Cembrowski George 
Published: September 2018

Abstract

Background
Cardiac troponin I (cTnI) 99th percentile cutoffs, used in the diagnosis of acute myocardial infarction, are not standardized across cTnI assays. We compared 3 point-of-care (POC) and 1 central laboratory contemporary cTnI assays against the Abbott high-sensitivity (hs) cTnI to evaluate the analytical concordance and the feasibility of using a single cutoff value for all assays.

Methods
Fresh blood samples collected from 102 inpatients in the coronary care unit were measured on central laboratory instruments (Beckman Coulter DxI AccuTnI+3 TnI, Abbott Architect hs-TnI) and cTnI POC analyzers (Alere Triage Troponin I, Radiometer AQT90, Abbott i-STAT). Agreement and correlation between the contemporary cTnI assays and hs-cTnI assay were assessed using regression analysis. Proportional bias was assessed using Bland–Altman plots. Concordance between the contemporary cTnI and hs-cTnI assays was determined by diagnostic contingency tables at specific cutoffs.

Results
Most POC cTnI assays had excellent correlation with the Abbott hs-cTnI method (r 2 = 0.955–0.970) except for Alere Triage (r 2 = 0.617), while proportional bias is evident between all cTnI assays. Overall concordance between POC contemporary cTnI assays and hs-cTnI assay was 80% to 90% at their respective 99th percentile cutoffs. The concordance increased to 90% to 95% when a fixed cutoff of 0.03 to 0.05 ng/mL was used across the assays.

Conclusions
This study demonstrates poor analytical concordance between cTnI assays at the 99th percentile and supports the notion of a single clinical decision limit for cTnI and consequently standardization of diagnostic protocols despite the analytical differences among these assays.
Risk factors for osteoporosis in men aged 40 years or older: the results of the program «Osteoscreening-Russia»
Authors: Nikitinskaya O. A. , Toroptsova N. V. , Nasonov E. L. 
Published: September 2018

Objective:to estimate the prevalence of individual risk factors (RFs) for osteoporosis (OP) and fractures, the frequency of high-risk osteoporotic fractures by the Fracture Risk Assessment Tool (FRAXR) and OP according to distal forearm X-ray densitometric findings in men aged 50 years or older in different regions of Russia.Patients and methods.Random cluster proportionally stratified samples of men aged 40 years or older were formed in the district polyclinics of 23 towns of the country with over 100,000 people in the framework of the social program «Osteoscreening-Russia» (OSR). The survey was conducted using a unified questionnaire. Screening also involved a densitometric study of distal forearm bone mineral density using a peripheral X-ray osteodensitometer (Osteometer Meditech DTX-200). The final analysis included 5057 men from 14 towns of 5 federal districts (FDs) of Russia.Results.Estimation of the prevalence of individual RFs for osteoporotic fractures in men aged 40 years or older showed that the most common RFs were insufficient dietary calcium intake (91%), smoking (30%), low-energy fractures in the history (20%), low physical activity (16%), and secondary causes of OP (11%). The men in the Ural FD (UFD), Siberian FD, and Central FD were more frequently found to have ≥3 RFs. 5% of men aged 50 years or older were at high risk for osteoporotic fractures by FRAXR, whereas the frequency of OP according to peripheral densitometric findings was 19%. The inhabitants of the North-Western FD and UFD had the greatest need for medical and preventive measures, which was identified by the FRAXR algorithm.Conclusion.The OSR survey could reveal the most common clinical RFs for OP and osteoporotic fractures in men in 5 regions of the Russian Federation, insufficient dietary calcium intake and assess the risk of osteoporotic fractures and the rate of OP according to peripheral densitometric findings.
Repeated short cycles of nonsteroidal anti-inflammatory drugs and kidney injury in patients with spinal degenerative-dystrophic diseases
Authors: Bichurina D. M. , Gaydukova I. Z. , Patrikeeva D. А. , Rebrov A. P. 
Published: September 2018

Objective:to evaluate kidney function in patients with spinal degenerative-dystrophic diseases (SDDDs) who take nonsteroidal anti-inflammatory drugs (NSAIDs) as repeated short cycles of treatment for severe back pain.Patients and methods.The investigation enrolled 97 patients with SDDDs who took NSAIDs for back pain (a study group). A control group consisted of sexand age-matched healthy individuals who had not used NSAIDs within the past year (n=40). Glomerular filtration rate (GFR) was estimated using the CKD-EPI equation and markers of kidney injury (albuminuria and globulinuria) were measured.Results.In the study group, GFR was decreased to <90 ml/min/1.73 m2 in 61 (62.9%) patients, to <60 ml/min/1.73 m2 in 11 (11.3%); the mean GFR was 77.5 [68.0; 89.0] ml/min/1.73 m2; in the control group, a decline in GFR to 89–60 ml/min/1.73 m2 was recorded in 35 (62.5%) cases; this indicator was >90 ml/min/1.73 m2 in the remaining 15 (37.5%) cases; the mean GFR was 82.5 [70.8; 90.0] ml/min/1.73 m2 (p≥0.05 for all pairwise comparisons). A decrease in GFR to <60 ml/min/1.73 m2 was found in 11 (11.3%) patients in the study group and in nobody in the control group (p=0.026). Elevated albuminuria was noted in 74 (76.3%) patients with SDDDs and in 9 (22.5%) healthy individuals (p<0.05). Albumin/creatinine ratio was 57.1 [33.8; 82.4] mg/g in the study group and 25.0 [17.5; 32.9] mg/g in the control group (p<0.0001). Increased globulinuria was established in all the patients with SDDDs and only in 3 (7.5%) healthy examinees. Globulin/creatinine ratio was 134.7 [77.5; 197.7] mg/g in the study group and 12.9 [0.5; 18.1] mg/g in the control group (p<0.0001).Conclusion. A decline in GFR to <60 ml/min/1.73 m2 was more often seen in the patients taking NSAIDs for spine pain caused by SDDDs than in the healthy individuals. In case of comparable GFR, the level of kidney injury markers was significantly higher in the study group than that in the control group, which suggests that patients with SDDDs who take NSAIDs have subclinical tubulointerstitial and glomerular changes.
Comparativo entre indicadores de sustentabilidade na gestão de resíduos sólidos em duas cidades brasileiras
Authors: Valim Luciane Herbst , Dos Santos Antônio José , Duarte Marcia Adriana Tomaz , Gouvea Carlos Alberto Klimeck 
Published: September 2018

O presente estudo aborda os aspectos de sustentabilidade ambiental do sistema de gestão de resíduos sólidos urbanos (GRSU) na cidade Joinville, através do uso de Matriz de Sustentabilidade, e compara com o resultado obtido na cidade de Feira de Santana. Essa Matriz contempla 42 indicadores e 126 descritores e apresentou como resultado uma avaliação relativamente fiel à condição da GRSU das cidades avaliadas, apresentando nota 6,7 para Joinville e 4,1 para Feira de Santana, de um máximo de 10. Mesmo assim, são apresentadas as deficiências encontradas e propostas melhorias para essa matriz. Também foi utilizado o Índice de Sustentabilidade de Limpeza Urbana (ISLU) do Sindicato das Empresas de Limpeza Urbana no Estado de São Paulo para avaliação dos mesmos municípios e constatado que esse Índice dá classificação C, a mesma para cidades com realidades bastante distintas, o que não permite seu uso como direcionamento para a gestão da sustentabilidade a que se propõe.
SINTESIS DAN KARAKTERISASI ZnO SEBAGAI COATING ANTIKOROSI ZnO/Al(OH)3 PADA MATERIAL BAJA KARBON
Authors: Setiawan Adhi 
Published: September 2018

ZnO seringkali digunakan sebagai aplikasi pigmen anti korosi pada logam karena tidak beracun, ramah lingkungan, murah serta memiliki ketahanan korosi yang relatif baik. Artikel ini memuat penelitian dalam melakukan sintesa partikel ZnO menggunakan metode presipitasi dengan ZnCl2 dan NaOH sebagai prekursor. Partikel ZnO yang dihasilkan memiliki morfologi berbentuk batang dengan ujung lancip. Hasil SEM menunjukkan bahwa pada konsentrasi NaOH sebesar 0,5 M dihasilkan ZnO dengan ukuran terkecil sebesar 123 nm dan hasil XRD menunjukkan bahwa ZnO memiliki kristalinitas tinggi dengan ukuran kristal mencapai 47 nm. Hasil penelitian menunjukkan bahwa pada komposisi ZnO/Al(OH)3 sebesar 1:3 menjadikan specimen baja karbon memiliki ketahanan korosi yang terbaik dengan nilai laju korosi terendah sebesar 0,86 mpy.
Ty vole jako multifunkční komunikační prostředek v současné češtině
Authors: Ludwicki Antoni , Škodová Svatava 
Published: September 2018

Příspěvek se zabývá používáním prostředku ty vole v současné mluvené češtině. Prostřednictvím kvalitativní analýzy materiálu mluvených korpusů češtiny příspěvek dokládá, že tento původně vulgární výraz v současné češtině ztratil v některých kontextech svou hanlivou náplň a je užíván i s jinými významy než vulgárními či depreciativními. Zároveň je možné sledovat i posun v jeho morfologickém zařazení, v současné době ne vždy lze charakterizovat jeho formu jako vokativ substantiva vůl, tj. následně i jeho postavení ve funkci kontaktové jako oslovení komunikačního partnera, ale dochází k jeho formálnímu ustrnutí do podoby částice a paralelně s tím, získává nové komunikační funkce. Cílem analýzy je popis komunikačních funkcí, do nichž prostředek ty vole vstupuje. Korpusová analýza je provázena elicitační výzkumnou sondou mezi zahraničními studenty bohemistiky. Cílem elicitace jsou individuální interpretace kontextů a cílů užití slovního spojení ty vole.
Infant Walker–Related Injuries in the United States
Authors: Sims Ariel , Chounthirath Thitphalak , Yang Jingzhen , Hodges Nichole L. , Smith Gary A. 
Published: September 2018

OBJECTIVES:To investigate the epidemiologic characteristics of infant walker–related injuries among children &lt;15 months old who were treated in US emergency departments and to evaluate the effect of the 2010 federal mandatory safety standard on these injuries.METHODS:National Electronic Injury Surveillance System data from 1990 to 2014 were analyzed.RESULTS:An estimated 230 676 children &lt;15 months old were treated for infant walker–related injuries in US emergency departments from 1990 to 2014. Most of the children sustained head or neck injuries (90.6%) and 74.1% were injured by falling down the stairs in an infant walker. Among patients who were admitted to the hospital (4.5%), 37.8% had a skull fracture. From 1990 to 2003, overall infant walker–related injuries and injuries related to falling down the stairs decreased by 84.5% and 91.0%, respectively. The average annual number of injuries decreased by 22.7% (P = .019) during the 4-year period after the implementation of the federal mandatory safety standard compared with the 4-year period before the standard.CONCLUSIONS:Infant walker–related injuries decreased after the implementation of the federal mandatory safety standard in 2010. This decrease may, in part, be attributable to the standard as well as other factors, such as decreased infant walker use and fewer older infant walkers in homes. Despite the decline in injuries, infant walkers remain an important and preventable source of injury among young children, which supports the American Academy of Pediatrics’ call for a ban on their manufacture and sale in the United States.
Geografía agraria brasileña: génesis y diversidad
Authors: Suzuki Julio César 
Published: September 2018

La geografía agraria es muy reciente; su definición como un fragmento del saber no tiene más de medio siglo. Sin embargo, el conocimiento sobre el campo es casi tan antiguo como la propia historia del hombre, por lo menos aquella referente al hombre cuya práctica de la agricultura alteró las posibilidades de desarrollo social. De esta forma, entendemos la geografía agraria como un momento particular de estructuración del conocimiento sobre el campo y la agricultura, basado en la sistematización del conocimiento a partir de los principios científicos. En estos términos, este artículo analiza el movimiento de transformación del pensamiento en la geografía agraria brasileña, tomando como referencia, sobre todo, el contexto interno de la geografía, aunque también el contexto social. Para esto, se discuten la génesis de la geografía agraria a partir de las lecturas que se enfocaron en ella, así como su definición como área del conocimiento, que si bien ha estado marcada por una gran diversidad teórico-metodológica, también constituye una unidad como campo del saber.
Repercusiones del cambio climático global en el estado de Sinaloa, México
Authors: Flores Campaña Luis Miguel , Arzola-González Juan Francisco , Ramírez-Soto Milagros , Osorio-Pérez Amador 
Published: September 2018

Las variaciones en las condiciones ambientales del estado de Sinaloa asociadas al cambio climático global han sido poco estudiadas, al igual que su impacto en las principales actividades productivas de la región. Aquí se describen diversos fenómenos asociados al cambio climático y sus consecuencias para Sinaloa. Se analizan los escasos escenarios del clima donde se incluye a la región y se cuestionan las modificaciones asociadas a ciclones tropicales y a cambios interanuales. Se discuten las repercusiones del cambio climático en la actividad agrícola y aspectos relacionados con el ascenso del nivel del mar. Llama la atención la falta de estimaciones y estudios locales que sirvan de base para planificar mejor estrategias e iniciativas que faciliten la adaptación al cambio climático en la región.
Territorios, culturas y jerarquización socioespacial en la migración contemporánea
Authors: Rincón Gamba Laura 
Published: September 2018

En este artículo se plantea que el problema social derivado de los procesos migratorios contemporáneos se entiende en el marco del reposicionamiento y profundización de las jerarquías socioespaciales. Esta hipótesis se desarrolla al reconocer que la pertenencia territorial de las personas resurge como criterio de diferenciación, clasificación y jerarquización social, y que las culturas y los territorios se superponen de manera natural. Esto implica que la condición de migrante, articulada a otras categorías de jerarquización social, como la clase y la pertenencia étnico-nacional, entre otras, conlleva condiciones de exclusión y dominación.
Mapeamento de adequação de uso das terras atráves da técnica de análise de multicritério em ambiente SIG: estudo de caso do município de conde - PB, Brasil
Authors: Firmino Barbosa Maria Emanuella , Furrier Max , Viana de Lima Eduardo Rodrigues 
Published: September 2018

El presente trabajo tiene como objetivo estudiar los mapas de aptitud y capacidad de uso de la tierra en el municipio de Conde, estado de Paraíba, Brasil. Este estudio se realizó por medio de la creación y estructuración de una base de datos utilizando técnicas de sensores remotos y Sistemas de Información Geográfica (SIG). Para la preparación del material cartográfico y para la adquisición de los datos cuantitativos de la zona se utilizó el software SPRING 5.1.7. Los mapas producidos fueron: de suelos, uso y ocupación, inclinación de las vertientes, capacidad de uso de la tierra y la aptitud de uso de la tierra. Se encontró que en la mayor parte del municipio de Conde presenta terrenos de alta correspondencia entre aptitud y uso, con área total de 103,3 km².
Análisis multitemporal y de la estructura horizontal de la cobertura de la tierra: Parque Nacional Yacambú, estado Lara, Venezuela
Authors: Molina Gladys Z. , Albarran Anderson J 
Published: September 2018

Para determinar el estado de conservación de las coberturas de la tierra del Parque Nacional Yacambú para el periodo 2000-2008, se realizó un análisis de su estructura horizontal considerando su evolución temporal y composición estructural. La evolución temporal, lograda a partir de la superposición de mapas de cobertura obtenidos de imágenes de satélite, reveló que se presenta un alto grado de conservación de las coberturas en áreas distantes a las vías de acceso y una importante afectación, por expansión de la frontera agrícola, en las áreas limítrofes. La composición estructural, obtenida a través del cálculo de índices estructurales, apunta a procesos de fragmentación en algunas coberturas naturales.
Gentrificación de La Candelaria: reconfiguraciones de lugar de residencia y consumo de grupos de altos ingresos
Authors: Manrique Gómez Adrian Smith 
Published: September 2018

El sector de La Candelaria (Bogotá D. C., Colombia) ha vuelto a ser un lugar de consumo y residencia de grupos de personas de altos ingresos económicos, luego de su abandono a mediados del siglo XX por efecto de múltiples problemáticas urbanas. Esta dinámica de relocalización es conocida por la geografía urbana como gentrificación; tendencia previamente registrada en otras urbes e integrante del proceso global de construcción urbana. El artículo ofrece una lectura de dicha dinámica urbana bogotana a partir del análisis de sus causas, el seguimiento a su funcionamiento y sus consecuencias.
The beginning of the program of multiorgan postmortem donation and transplantation in the Republic of Sakha (Yakutia)
Authors: Meshcherin S. S. , Tatarinova O. V. , Vasiliev A. I. , Zolotareva A. G. , Tyryshkina E. V. , Alekseeva L. M. , Timofeev A. A. , Andreev B. V. , Khomyakov S. M. 
Published: September 2018

The article is devoted to the main aspects of organization of multiorgan donation from donors with brain death in the Republic of Sakha (Yakutia). Transplant services to the population of this region have been in place since 2001, and until 2016 only kidney transplants or liver fragments from a living related donor have been performed. The presence of an effective postmortem donation program will allow to meet the high demand of this region for high-tech assistance by organ transplantation.
Sports for patients with transplanted organs
Authors: Shelekhova T. Yu. , Achkasov E. E. , Tsirulnikova O. M. , Zaborova V. A. , Shults I. M. , Ahmadzai R. L. 
Published: September 2018

The article offers analysis of the problem status as well as World and Russian experience of donor organ recipients participation in sports and physical training. The connection of physical activity with the quality of life of patients after transplantation is reflected. The problems associated with organ donation in Russia and other countries and the importance of sports activities in promoting this problem are described. The analysis of foreign experience in the organization of sports games for people with transplanted organs, which indicates: the importance of research methods in admission to physical education and sports among recipients, the need for dosing and selection of physical activity, the involvement of a transplant doctor for individualization of rehabilitation programs. The personal experience of foreign athletes with transplanted organs, including the experience of the Russian recipient’s participation in the 21st world games 2017 is presented. Experience of carrying out sports activities for people with transplanted organs in Russia is also given.
Autotransplantation of T-lymphocytes as a tool for antigen-specific immunotherapy of oncological diseases
Authors: Lupatov A. Yu. , Karalkin P. A. , Boyko A. A. , Yarygin K. N. 
Published: September 2018

Autotransplantation of immune cells to induce immunological rejection of tumors can be a useful approach in tumor treatment. Despite the low efficiency of this approach demonstrated in the past, the active development of cell technologies and genetic engineering has led to the significant improvement in clinical outcomes. A great success was achieved in adoptive immunotherapy with the T-lymphocytes specific to tumor antigens. This review describes the clinical experience in application of various antigen-specific adoptive immunotherapy methods including tumor-infiltrating T-lymphocytes, T-lymphocytes with redirected transgenic T-cell and chimeric antigenrecognizing receptors. The possibilities and limitations of these biomedical technologies are also analyzed in the article.
Model regulatory networks for proteins that are activated and inhibited in the process of induced granulocyte differentiation
Authors: Novikova S. E. , Tikhonova O. V. , Kurbatov L. K. , Vakhrushev I. V. , Zgoda V. G. 
Published: September 2018

Differentiation therapy with all trans retinoic acid (ATRA) is successfully used for the treatment of acute promyelocytic leukemia (APL). At the same time, the development of the resistance and the differentiation syndrome as a side effect is a reason to explore and examine in greater depth the molecular basis of the differentiation therapy and to search the alternative paradigm of the treatment. By the use of ATRA-treated HL-60 cell line as a model object, we have estimated 76 activated and 101 inhibited proteins by the label-free mass-spectrometric profiling. By applying the bioinformatic approach we have obtained model schemes of regulation of the inhibited and activated proteins whose key molecules turn out to be the histone deacetylase 1 (HDAC1) and the transcriptional corepressor (RNF96) respectively. Both of predicted key molecules have been detected in HL-60 cell line at the proteome level in conjunction with Cdk2, DNA-PKcs, Ubc9 and HMGIY molecules in the model scheme regulating the activated protein cluster and the protein kinase p38 alpha involved in the regulating scheme of the inhibited proteins. The pharmacological targeting of these molecules may have an antiproliferative effect and provide the alternative approach to APL treatment.
Persepsi Orang Tua dan Guru Mengenai Bahasa Inggris pada Anak Usia Dini di TK ABA Karangmalang Yogyakarta
Authors: Diniyah Faqihatud 
Published: September 2018

Tesis ini bertujuan untuk mengetahui persepsi orang tua dan guru mengenai pentingnya bahasa Inggris untuk anak usia dini. Penelitian ini merupakan penelitian kualitatif dengan pendekatan deskriptif kualitatif melalui FGD yang dilaksanakan di TK ABA Karangmalang Yogyakarta. Hasil penelitian ini menunjukkan bahwa sebagian besar orang tua dan guru menjawab bahwa pentingnya bahasa Inggris pada anak usia dini, semakin dini anak-anak diajarkan semakin baik untuk ingatan dan pembentukan otak mereka, anak-anak memiliki rasa ingin tahu yang tinggi akan lebih bermanfaat jika diisi dengan pembelajaran bahasa Inggris dan bahasa lainnya, ini juga berkaitan dengan masa emas perkembangan anak. Faktor bahasa Inggris pada anak adalah membawa pengaruh positif yang mampu meningkatkan pemerolehan bahasa anak pada perkembangan bahasa anak, sedangkan faktor bahasa Inggris pada anak juga membawa pengaruh negatif yaitu rendahnya kemampuan anak tentang bahasa pertama.
Interferensi Sintaksis Bahasa Katingan Terhadap Bahasa Indonesia di SMP Negeri 1 Katingan Tengah Kabupaten Katingan Kalimantan Tengah
Authors: Cahyani Irni 
Published: September 2018

Tujuan penelitian ini ialah transfer negatif lebih dikenal dengan istilah interferensi dalam pemerolehan bahasa kedua. Istilah interferensi mengacu pada dua fenomena linguistik yang berbeda, yaitu interferensi psikologis dan interferensi sosiolinguistik. Interferensi psikologis mengacu kepada pengaruh kebiasaan lama sebagai hasil mempelajari sesuatu terhadap sesuatu yang sedang dipelajari. Sedangkan interferensi sosiolinguistik mengacu pada interaksi bahasa, misalnya pinjaman atau alih sandi. Faktor yang menyebabkan terjadinya interferensi adalah faktor kontak bahasa dan faktor kemampuan berbahasa. Hasil penelitian aspek interferensi sintaksis bahasa Katingan terhadap bahasa Indonesia yaitu ditemukan dua jenis interferensi sintaksis yang terdapat dalam bahasa lisan dan tulisan siswa SMPN 1 Katingan Tengah antara lain: (1) Interferensi frasa terhadap bahasa Indonesia dan (2) Interferensi kalimat terhadap bahasa Indonesia.