bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for non-adherence to oral anticoagulant therapy and the potential of their modification in patients with atrial fibrillation: a narrative literature review
Authors: Felikov I. M. , Kashtalap V. V. 
Published: November 2024

Medication adherence is a key factor of effective stroke prevention in patients with atrial fibrillation receiving oral anticoagulant therapy. At the same time, patient compliance can significantly decrease over time, which leads to an increased thromboembolism risk. A number of studies have shown that a large number of patients receiving anticoagulant therapy are insufficiently adherent to therapy (according to various sources, from 30 to 50% of patients do not comply with the prescribed treatment regimen or interrupt therapy).Independent risk factors for non-compliance include younger age, old age, prior stroke, male sex, multimorbidity, polypharmacy. The risk of decreased compliance with double drug intake compared to single one is noted separately.The review aim is to study the risk factors for non-adherence to oral anticoagulants in patients with atrial fibrillation and possible measures for its prevention.
Chemical structure analysis of chitosan-modified road bitumen after de-icing salt treatment
Authors: Malinowski Szymon 
Published: November 2024

AbstractAsphalt pavements are constantly exposed to many destructive environmental factors including de-icing salts. The problem of the negative effect of salt ions on the performance and consequently the durability of road pavements occurs mainly in temperate climates and regions directly neighboring saline water areas. The salt ions react chemically with the bitumen components, which consequently changes their electronic structure and results in a weakening of the intermolecular interactions occurring between them. Therefore, this study focused primarily on an investigation into the potential for inhibiting the destructive erosion process of bitumen by its modification with chitosan. Studies involving changes in the acidity of the eroding solution as well as chemical and surface properties of the eroded bitumen were carried out for three different salts (NaCl, MgCl2, CaCl2) at varying concentrations, i.e. 5%, 10%, 15% (w/w) after 7 and 28 days of erosion process. Main findings demonstrate that chitosan prevents negative changes in the bitumen physico-chemical properties occurring during the salt erosion process. This effect is especially visible for the bitumen eroded with a solution of MgCl2 and CaCl2. For these salts, chitosan biopolymer reduces the introduction of Cl− ions into the bitumen-building hydrocarbon structures and formation of C–Cl bonds, which is demonstrated by a reduction in the pH changes of the eroding solutions. In addition, chitosan biopolymer inhibits leaching of organic matter from the bitumen, prevents C = O groups formation and reduces the negative effects of de-icing salts on the cohesion energy of the bitumen.
Reduced Injection Rates and Shallower Depths Mitigated Induced Seismicity in Oklahoma
Authors: Skoumal Robert J. , Barbour Andrew J. , Rubinstein Justin L. , Glasgow Margaret E. 
Published: November 2024

Abstract
The proximity of wastewater disposal to the Precambrian basement is a critical factor influencing induced earthquake rates in the Central United States, but the impact of reducing injection depths has not been widely demonstrated. Beginning in 2015, state regulatory efforts in Oklahoma and Kansas mandated that wells injecting into the lower Arbuckle Group, a basal sedimentary unit, be backfilled with cement (i.e., “plugged back”) so that they inject into shallower formations. This plug back activity gives us a unique opportunity to investigate the relationship between injection depth and induced seismicity rate. To evaluate the impact that decreased injection rates and plug backs had on the seismicity rates, we created a suite of rate–state earthquake models. Observed seismicity rates are best fit when only lower Arbuckle volumes are considered, suggesting the lower Arbuckle injectors were primarily responsible for the seismicity and that plug backs were effective at isolating the injected volumes to shallower formations. Our models demonstrate that if these wells had not been plugged back, seismicity rates would be multiple times larger than they are today. We find that the combination of well plug backs and injection volume decreases can be an effective strategy for reducing induced seismicity rates.
Pengaruh Lama Waktu Penggunaan Alat Pembersih Terhadap Kemurnian Benih Jagung Manis (Zea mays L. Saccharata)
Authors: Hayati Berlina Nur , Wijayanto Budi , Astuti Siti 
Published: November 2024

Abstrak. Penggunaan alat pembersih tentunya memiliki kecepatan pembersihan yang lebih cepat dibandingkan dengan cara manual menggunakan tampi. Namun penggunaan alat pembersih terbukti masih menyisakan kotoran yang tidak seharusnya tercampur lagi dengan benih. Penelitian ini bertujuan untuk mengetahui pengaruh waktu penggunaan alat pembersih terhadap kemurnian benih jagung manis. Penelitian ini dilaksanakan pada bulan Maret 2023 di UD Agro Nusantara Prima, Sewon, Kabupaten Bantul dan Laboratorium Teknologi Benih Kampus Polbangtan Jurusan Pertanian, Yogyakarta. Penelitian ini dilakukan dengan Rancangan Acak Lengkap (RAL) Non Faktorial dengan menggunakan faktor frekuensi pembersihan yaitu frekuensi pembersihan menggunakan tampi, frekuensi pembersihan menggunakan alat sebanyak satu kali, dua kali, tiga kali, empat kali, dan lima kali. Hasil penelitian dianalisis menggunakan pengujian sidik ragam ANOVA dengan taraf 1% dan 5% dan apabila terdapat pengaruh nyata maka dapat dilanjutkan menggunakan uji lanjut BNT dengan taraf 5%. Hasil penelitian menunjukkan bahwa waktu hasil kerja pembersihan benih menggunakan alat sebesar 99,64% berbeda nyata dengan efisiensi pembersihan menggunakan tampi sebesar 97,67%. Frekuensi pembersihan dengan alat sebanyak satu kali merupakan perlakuan terbaik untuk menghasilkan benih murni sebesar 99,48%. The Effect Of Length Time Cleaning Tools Usage On The Pure Of Sweet Corn (Zea mays L. Saccharata) SeedsAbstract. The use of cleaning tools certainly has a faster cleaning speed compared to the manual method using tampi. However, the use of cleaning tools is proven to still leave dirt that should not be mixed again with seeds. This study aims to determine the effect of the time of using cleaning tools on the purity of sweet corn seeds. This research was conducted in March 2023 at UD Agro Nusantara Prima, Sewon, Bantul Regency and Seed Technology Laboratory of Polbangtan Campus, Yogyakarta. This research was conducted with a Non-Factorial Completely Randomized Design (CRD) using the cleaning frequency factor, namely the frequency of cleaning using tampi, the frequency of cleaning using tools once, twice, three times, four times, and five times. The results of the study were analyzed using ANOVA variance testing at the 1% and 5% levels and if there is a real effect, further test can be carried out of using the BNT with a level of 5%. The results showed that the working time of seed cleaning using a tool of 99.64% was significantly different from the efficiency of cleaning using tampi of 97.67%. The frequency of cleaning with the tool once is the best treatment to produce pure seeds of 99.48%.
Prediksi Konduktivitas Hidrolik Jenuh (Ks) Menggunakan Fungsi Pedoftransfer di Lahan Kering Kabupaten Sumbawa
Authors: Ayu Ieke Wulan , Mechram Siti , Soemarno Soemarno 
Published: November 2024

Abstrak. Konduktivitas hidrolik jenuh (Ks) adalah parameter kunci untuk perencanaan irigasi, drainase, pemodelan limpasan permukaan dan fenomena erosi di daerah yang terbentuk oleh tanah. Pengukuran Ks di laboratorium membutuhkan biaya dan waktu yang lama sehingga menggunakan model pedotransfer (PTF) menjadi alternatif pilihan yang dapat digunakan dalam menentukan parameter hidrofisika tanah secara cepat. Penelitian ini bertujuan untuk memprediksi nilai konduktivitas hidrolik jenuh tanah (Ks) di lahan kering Kabupaten Sumbawa. Penelitian dilaksanakan dari bulan bulan Maret 2021 sampai dengan Agustus 2022 di Desa Jotang dan Desa Ongko, Kecamatan Empang, dan Desa Brora Kecamatan Lape, Kabupaten Sumbawa, Provinsi Nusa Tenggara Barat. Metode penelitian menggunakan rancangan deskriptif komparatif terhadap karakter sifat fisika dan kimia tanah melalui pengambilan sampel tanah tidak terganggu menggunakan ring sampel untuk analisis tanah, serta perakitan file input dan simulasi menggunakan program model Soil, Plant, Atmosphere, Water Field and Pond Hydrology Model (SPAW) Version 6.02.75. Hasil analisis menunjukkan bahwa nilai Ks pada lokasi penelitian 0,10-0,40 in/jam. Penentuan Ks di lahan kering dapat menggunakan metode PTFs dengan masukan parameter minimal yaitu tekstur tanah (pasir dan liat), dan bahan organik. Prediction of Saturated Hydraulic Conductivity (Ks) Using Pedoftransfer Function in Drylands of Sumbawa Regency Abstract. Saturated hydraulic conductivity (Ks) is a key parameter for irrigation planning, drainage, modeling of surface slip and erosion phenomena in areas formed by soil. Measuring Ks in the laboratory is costly and time-consuming so using a pedotransfer model (PTF) is an alternative option that can be used in determining soil hydrophysical parameters quickly. This study aims to predict the value of soil-saturated hydraulic conductivity (Ks) in the dry land of Sumbawa district. The research was carried out from March 2021 to August 2022 in Jotang Village and Ongko Village, Empang District, and Lape District Brora Village, Sumbawa District, West Nusa Tenggara Province. The research method uses comparative descriptive designs to characterize soil physical and chemical properties through uninterrupted soil sampling using sample rings for soil analysis, as well as assembly of input files and simulations using Soil, Plant, Atmosphere, Water Field and Pond Hydrology Model (SPAW) Version 6.02.75. The results of the analysis showed that the Ks value at the study site was 0.10-0.40 in/hour. Determination of Ks in dry soil can be done using PTFs method with input of minimum parameters namely soil texture (sand and clay), and organic material.
Nutrition Training in Medical Education Among Family Medicine Residents in North Carolina
Authors: Sykes Jeannie , Cassidy-Vu Lisa , Richter Scott , Parker Michael , Eniola Kehinde 
Published: November 2024

Background This study surveyed family medicine residents in North Carolina regarding the state of nutrition education in their residency training. In addition, the survey explored comfort levels with, and attitudes about, discussing nutrition with patients. Methods We administered an online questionnaire to family medicine residents in North Carolina (n = 384) asking about their history of nutrition training and their current attitudes about nutrition. The 24-item survey included both Yes and No and Likert-scale responses. Results All but one resident had received formal or informal nutrition training during their medical education. Residents overwhelmingly considered nutrition to be an important component of health care, although a majority felt physicians are inadequately trained in nutrition. Feeling comfortable discussing nutrition with patients regarding specific health conditions varied from 45% (gastrointestinal concerns) to 94% (cardiovascular disease) or 95% (diabetes) among residents. Limitations The volunteer sampling method used in the study may limit generalizability of the study findings to a broader population of family medicine residents. In addition, precisely defining “formal” and “informal” nutrition training on the survey questionnaire would help to clarify the role of nutrition education in shaping resident attitudes and practices. Conclusion This study shows that family medicine residents recognize the importance of nutrition education but do not feel adequately trained to provide it to patients. Given the abundance of evidence linking nutrition and health as well as an apparent interest among family medicine residents in nutrition education, this study supports the integration of nutrition training in medical education. Suggestions for how to accomplish this objective are provided.
High Rates of Obesity and Chronic Diseases Among North Carolina United Methodist Clergy: An Updated Analysis
Authors: Lee Bo-Hyeong Jane , Yao Jia , Ramcharitar-Bourne Anisa , Proeschold-Bell Rae Jean 
Published: November 2024

Background Varied demands and stressors experienced by clergy can contribute adversely to their overall well-being. Data from United Methodist Church (UMC) clergy in North Carolina in 2008 revealed that clergy had significantly higher non-communicable disease (NCD) rates than their fellow North Carolinians. Methods Using data from the Clergy Health Initiative and Behavioral Risk Factor Surveillance Survey, the present study provided an updated analysis of obesity and 6 other NCDs among North Carolina UMC clergy compared to the general North Carolina population. First, we described the prevalence of each health condition among North Carolina UMC clergy and the general North Carolina population across multiple waves from 2008 to 2021. Then, we compared the predicted probabilities of each health condition in 2021 using logistic regressions to adjust for age, sex, and race. Results Comparing the unadjusted prevalence of health conditions between 2008 and 2021, we found that North Carolina UMC clergy have higher rates of obesity, hypertension, hypercholesterolemia, diabetes, angina, arthritis, and asthma than North Carolinians overall. Adjusting for age, sex, and race, we found that significantly higher rates of obesity, severe obesity, hypercholesterolemia, and asthma persisted among UMC clergy in 2021 compared to all North Carolinians, with the higher rates of severe obesity being particularly concerning. Limitations While the current study is limited to an update of health prevalence among UMC clergy, pastors across denominations are influential leaders in their communities, shaping the physical and social health environments of their congregations. Conclusions Further research is needed to investigate risk factors, such as relocation and adverse childhood experiences, which may influence the higher prevalence of NCDs within and potentially beyond the UMC.
North Carolina Academic Health Centers and Social Determinants of Health
Authors: Caruana Marc , Weinberger Morris , Shea Christopher M. 
Published: November 2024

Background Academic health centers (AHCs) have traditionally focused on 3 core missions: patient care, research, and education. The current changing health care environment requires AHCs to broaden their focus to improve the health of their communities. This study reports the opportunities and challenges for the 5 North Carolina AHCs addressing social determinants of health (SDOH). Methods We used a mixed methods design. We analyzed financial data from systemwide community benefits reports and the Form 990 Schedule H of the primary medical centers (when available) from the 5 AHCs, and we conducted 4 key informant (KI) interviews at each of the 5 AHCs for a total of 20 interviews. Results Overall, AHCs spend a very small percentage of their total spending on community improvement services and community benefit operations. By far, the largest amount spent on community benefit is for treating patients eligible for charity care. Food insecurity and access to health care were the most addressed SDOH. Housing was viewed as a crisis that needed to be addressed at statewide and national levels. Limitations Community benefits reports from North Carolina AHCs lack important details. Key informant interviews provide far more recent information on the quantity and breadth of initiatives than the latest community benefits reports that were all completed pre-pandemic. We only interviewed 4 stakeholders from each AHC in North Carolina. Conclusion A new strategic vision must incorporate social accountability into the AHCs’ core missions to remove barriers and institute and sustain change, but the AHCs face a steep challenge to incorporate social accountability at a core mission level.
Il contributo delle Digital Humanities per un approcio allo studio dell’epigrafia Ispano-Romana
Authors: Bastero Acha Marina 
Published: November 2024

Within the various research areas of Ancient History, Digital Humanities have gained a significant role in recent years. However, in the more specific field of Epigraphy, which is the topic of this contribution, although the usefulness of Information and Communication Technologies (ICTs) has begun to be evaluated, these resources have largely been used as a complementary tool and not as an integral part of the epigraphic discipline. For this reason, it can be to present and describe those ICT-related tools that can be consider fundamental for a modern epigraphic study, with a particular focus on the Latin epigraphy of Roman Hispania.
Characteristics of lower extremity ulcers among patients treated at Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Bali
Authors: Puspita Sari Luh Gede Melia , Suryawati Nyoman 
Published: November 2024

Lower extremity ulcers are one of the ulcers that are difficult to heal. This condition causes significant morbidity, mortality, costs, and reduces the quality of life. Epidemiological studies in Indonesia often focus on diabetic foot ulcers, so a general description of lower extremity ulcers is still lacking. This study aimed to determine the characteristics of lower extremity ulcers in outpatients at the Dermatology and Venereology Outpatient Polyclinic, Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali. The data were taken retrospectively from medical records from January 2018 until December 2021. A total of 15 subjects were enrolled in this study. Among the subjects, 8 (53.3%) were male and 7 (46.6%) were female. The age group of 40 yo and over dominated this study (60%). The common ulcer predilection was on the cruris (42.1%) and the wound culture results were dominated by Staphylococcus aureus (40%). Comorbidities were found in 7 subjects (46.7%) and the majority was hypertension (42.8%). Several subjects also had additional diagnoses at the time of the visit, including Morbus Hansen (60%), deep vein thrombosis (10%), cellulitis (10%), pyoderma gangrenosum (10%), and systemic lupus erythematosus (10%). In conclusion, the most characteristics of lower extremity ulcer patients at Prof. Dr. I.G.N.G Ngoerah General Hospital are males, age group > 40 yr, with cruris as a predilection, and hypertension as the most common comorbid.
CEA and Cyfra 21-1 linked to serial miRNA expressions of advanced-stage non-small cell lung cancer in Indonesia
Authors: Hanafi Arif Riswahyudi , Jayusman Achmad Mulawarman , Imelda Priscillia , Alfasunu Serafim , Sadewa Ahmad Hamim , Pramono Dibyo , Heriyanto Didik Setyo , Haryana Sofia Mubarika , Kresno Siti Boedina 
Published: November 2024

Globally, lung cancer is one of the cancers leading to dead, dominated by non-small cell lung cancer (NSCLC). In a previous study has shown those serial miRNA expressions (miR-148, miR-34, miR-222, and miR-155) had prognostic value in advanced-stage NSCLC patients. Meanwhile, CEA and Cyfra 21-1, pulmonary tumor markers, are sometimes considered in the Department of Pulmonology, Dharmais Cancer Hospital, Jakarta, although they are not used in routine clinics for prognostication. Both miRNA and CEA-Cyfra 21-1 are valuable biomarkers in NSCLC. This study aimed to evaluate their correlation between CEA and/or Cyfra 21-1 with miRNA expressions in NSCLC patients. It was a cohort retrospective study using data from the previous study. The correlation between variables was analyzed by Spearman-rho. A positive correlation was observed between CEA and Cyfra 21-1 with miR-148, miR-222, and miR-155 [(CEA: p=0.00369, r=0.522; p=0.00242, r=0.542; p 0.00106, r=0.576) (Cyfra: 21-1= p 0.01252, r=0.378; p=0.00035, r=0.519; p=0.01532, r=0.368)]. In conclusion, CEA and Cyfra 21-1 correlate with miR-148, miR-222, and miR-155 expressions in advanced-stage NSCLC.
High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections
Authors: Hayati Hanifah Fajarisna , Satiti Sekar , Paryono Paryono , Intansari Umi , Sutarni Sri , Subagya Subagya , Indarwati Indarwati , Setyopranoto Ismail 
Published: November 2024

Central nervous system (CNS) infections such as encephalitis, meningitis, or myelitis have high morbidity and mortality in Indonesia. High sensitivity C-reactive protein (hs-CRP) is a sensitive marker of acute inflammation, while albumin is the most abundant protein component in plasma and cerebrospinal fluid (CSS). Infection triggers an inflammatory response so that an increase in the hs-CRP/albumin ratio (CAR) can be a predictor of worsening clinical outcome in patients with CNS infections. However, studies examining the predictor value of serum and CSF CAR on worsening clinical outcomes of patients are limited, particularly in CNS infections. The purpose of this study was to prove the CAR as a predictor of worsening clinical outcome in patients with CNS infections. It was an observational study using a prospective cohort design. Fifty subjects recruited until October 2021 at Dr. Sardjito General Hospital were involved. The multivariate regression analysis showed that serum CAR (OR=3.604; 95%CI=1.487-8.736; p =0.005) could be a single predictor. However, by combining three variables, namely serum CAR, CSF CAR, and decreased consciousness at admission, could be a stronger predictor of worsening clinical outcome in patients with CNS infection (AUC = 97.1%; 95%CI = 0.929-1.00; p <0.001). The optimal cut-off value for serum CAR was 1.35 (Youden index = 0.88, sensitivity = 96%, specificity = 92%) while for CSF CAR was 0.14 (Youden index = 0.60, sensitivity = 76%, specificity = 84%). In conclusion, a combination predictive model of three variables, namely serum CAR, CSF CAR, and awareness at admission can be a stronger predictor of clinical outcome in patients with CNS infection than serum CAR alone.
La marque « Végétal local » vue par EDF : analyse de filière et retours d’expérience
Authors: DIECKHOFF Léa , ROULEAU Juliette , DELESSE Florine , CLERMONT Sandra 
Published: November 2024

L’entreprise EDF, en tant qu’aménageur d’infrastructures majeures et gestionnaire de plus de 30 000 hectares de foncier terrestre en France continentale, collabore depuis plus de dix ans avec les Conservatoires botaniques nationaux sur l’origine du matériel végétal utilisé dans ses projets d’aménagement, de réhabilitation post-chantier et de restauration écologique. Cette collaboration se traduit notamment par un partenariat national initié dès la création en 2015 de la marque « Végétal local ». Cette dernière, animée par le réseau des Conservatoires botaniques nationaux, l’Afac-Agroforesteries et Plante & Cité, vise à garantir l’utilisation de matériel végétal adapté au territoire où les projets sont mis en place, dans un souci de protection de la diversité génétique. L’article présente la vision d’EDF sur la structuration de la filière, qui se distingue par un réseau d’animateurs locaux, un lien avec les acteurs de l’économie des territoires et une forte implication du monde de la formation et de la recherche. Un retour d’expérience sur les projets portés par EDF avec du « Végétal local « permet de mettre en lumière les avantages de la marque, mais aussi les défis qui vont de pair avec son utilisation.