bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human chaperones untangle fibrils of the Alzheimer protein Tau
Authors: Ferrari Luca , Geerts Willie J.C. , van Wezel Marloes , Kos Renate , Konstantoulea Aikaterini , van Bezouwen Laura S. , Förster Friedrich G. , Rüdiger Stefan G.D. 
Published: September 2018

AbstractAlzheimer’s Disease is the most common neurodegenerative disorder. A hallmark of this disease is aggregation of the protein Tau into fibrillar tangles, which is ultimately linked to neuronal death 1,2. Oligomeric precursors of Tau fibrils are suspected to be the neurotoxic agent while fibrils themselves may be less harmful end products of the aggregation process 3,4. Evolutionary conserved families of molecular chaperones maintain protein homeostasis in healthy cells, preventing aggregation 5,6. Here, we investigate whether such chaperones could possibly reverse the aggregation reaction and dissolve Tau fibrils. Indeed we find that the human Hsp70 chaperone system disaggregates Tau fibrils. Both the bacterial and human Hsp70 chaperone systems disassemble fibril superstructures assembled of several fibril strands into single fibrils, indicating that this is an evolutionary conserved capacity of the Hsp70 system. However, further disaggregation of Tau fibrils into oligomers and even monomers is reserved to the human homologue. Thus, although bacteria possess an effective machinery to dissolve amorphous aggregates 7-9, we see that they do not have the means to disaggregate fibrils. Fibrillar aggregates, therefore, require different chaperone systems than amorphous aggregates, and this is a property acquired by Hsp70 during evolution. This makes the Hsp70 system an interesting target for novel drug strategies in Alzheimer.
Intersectional research stories of responsibilising the family for food, feeding and health in the twenty-first century
Authors: Davis Teresa , Hogg Margaret K. , Marshall David , Petersen Alan , Schneider Tanja 
Published: September 2018

PurposeLiterature from across the social sciences and research evidence are used to highlight interdisciplinary and intersectional research approaches to food and family. Responsibilisation emerges as an important thematic thread, as family has (compared with the state and corporations) been increasingly made responsible for its members’ health and diet.Design/methodology/approachThree questions are addressed: first, to what extent food is fundamentally social, and integral to family identity, as reflected in the sociology of food; second, how debates about families and food are embedded in global, political and market systems; and third, how food work and caring became constructed as gendered.FindingsInterest in food can be traced back to early explorations of class, political economy, the development of commodity culture and gender relations. Research across the social sciences and humanities draws on concepts that are implicitly sociological. Food production, mortality and dietary patterns are inextricably linked to the economic/social organisation of capitalist societies, including its gender-based divisions of domestic labour. DeVault’s (1991) groundbreaking work reveals the physical and emotional work of providing/feeding families, and highlights both its class and gendered dimensions. Family mealtime practices have come to play a key role in the emotional reinforcement of the idea of the nuclear family.Originality/valueThis study highlights the imperative to take pluri-disciplinary and intersectional approaches to researching food and family. In addition, this paper emphasises that feeding the family is an inherently political, moral, ethical, social and emotional process, frequently associated with gendered constructions.
Intercultural household food tensions: a relational dialectics analysis
Authors: Rogan Donal , Piacentini Maria , Hopkinson Gill 
Published: September 2018

PurposeRecent global migration trends have led to an increased prevalence, and new patterning, of intercultural family configurations. This paper is about intercultural couples and how they manage tensions associated with change as they settle in their new cultural context. The focus is specifically on the role food plays in navigating these tensions and the effects on the couples’ relational cultures.Design/methodology/approachA qualitative relational–dialectic approach is taken for studying Polish–Irish intercultural couples. Engagement with relevant communities provided multiple points of access to informants.FindingsIntercultural tensions arise as the couples jointly transition, and food consumption represents implicit tensions in the household’s relational culture. Such tensions are sometimes resolved, but sometimes not, leading to enduring tensions. Dialectical movement causes change, which has developmental consequences for the couples’ relational cultures.Research limitations/implicationsThis study shows how the ways that tensions are addressed are fundamental to the formation of a relational family identity.Practical implicationsRecommendations emphasise the importance of understanding how the family relational culture develops in the creation of family food practices. Marketers can look at the ways of supporting the intercultural couple retain tradition, while smoothly navigating their new cultural context. Social policy analysts may reflect on the ways that the couples develop an intercultural identity rooted in each other’s culture, and the range of strategies to demonstrate they can synthesise and successfully negotiate the challenges they face.Originality/valueDealing simultaneously and separately with a variety of dialectical oppositions around food, intercultural couples weave together elements from each other’s cultures and simultaneously facilitate both relational and social change. Within the relationship, stability–change dialectic is experienced and negotiated, while at the relationship’s nexus with the couple’s social ecology, negotiating conventionality–uniqueness dialectic enables them reproduce or depart from societal conventions, and thus facilitate social change.
Lucky or privileged? Working with memory and reflexivity
Authors: Trimingham Jack Christine 
Published: September 2018

Purpose
Through a case study of the decision making that led to the writer becoming a teacher educator, the purpose of this paper is to contribute to historiography by exploring the complex process of surfacing and interpreting memory.

Design/methodology/approach
The methodology draws on the concepts of autobiographical memory and reflexivity, together with documentary and archival sources including newspapers and secondary sources.

Findings
The outcome reveals that the process of memory is complex. It illustrates that allowing the participant a wide scope to work with pivotal memories, which may include those referring to material objects, may lead to unexpected and compelling explanations that have the power to change thinking in regards to related aspects of educational history. In this particular case, the findings reveal the long-term impact of boarding school experience.

Originality/value
The paper expands the way in which educational historians may think about undertaking interviews by illustrating the need for investment of time and close attention to all memories, some of which may at first seem to be irrelevant. Additionally, while a significant amount of research had been published on the long-term impact of boarding school experience on students in the UK, a little critical historical work has been undertaken in regards to the Australian experience – this paper offers a unique contribution to the undertaking of that project.
Hybrid revised weighted fuzzy c-means clustering with Nelder-Mead simplex algorithm for generalized multisource Weber problem
Authors: Kucukdeniz Tarik , Esnaf Sakir 
Published: September 2018

Purpose
The purpose of this paper is to propose hybrid revised weighted fuzzy c-means (RWFCM) clustering and Nelder–Mead (NM) simplex algorithm, called as RWFCM-NM, for generalized multisource Weber problem (MWP).

Design/methodology/approach
Although the RWFCM claims that there is no obligation to sequentially use different methods together, NM’s local search advantage is investigated and performance of the proposed hybrid algorithm for generalized MWP is tested on well-known research data sets.

Findings
Test results state the outstanding performance of new hybrid RWFCM and NM simplex algorithm in terms of cost minimization and CPU times.

Originality/value
Proposed approach achieves better results in continuous facility location problems.
Logistics system for drinking water distribution in post disaster humanitarian relief, Al-Za’atari camp
Authors: Smadi Hazem , Al Theeb Nader , Bawa’neh Haneen 
Published: September 2018

Purpose
It is essential to provide drinking water to affected population directly after a disaster. The purpose of this paper is to develop an optimization methodology that helps in the distribution of drinking water in post-disaster situations.

Design/methodology/approach
The research was conducted on two phases: phase 1 aims at identifying an appropriate way to deliver drinking water to refugee camps from external sources, considering required drinking water quantities and four possible sources of water with respect to cost and risk assessments. Phase 2 investigates drinking water distribution within a refugee camp using covering models. The MCLP–optimal number of facilities model is proposed to ensure that the water is distributed and delivered to all individuals in a camp with minimum number of water storage tanks required. A control policy is proposed to ensure the fair distribution of water to all targeted individuals.

Findings
Al-Za’atari refugee camp, located in northeast of Jordan, was considered as the case study for this research. The result showed that the appropriate way to deliver water to the camp is by using tanker–trucks, and a minimum number of five tanks are required to distribute water to individuals inside the camp with respect to tank locations and the allocation of tank of each area.

Originality/value
The proposed methodology is essential in decision making for the distribution of drinking water in refugee camps in short-term needs. The model adds important value to the literature as the proposed problem has no solution in the literature before.
Reducing statistics anxiety using limited teaching resources
Authors: Nilsson Jonas , Carlsson Hauff Jeanette 
Published: September 2018

Purpose
Students in the marketing discipline have been reported to struggle with quantitative methods. This paper aims to focus on whether it is possible to increase student confidence and reduce anxiety with quantitative data analysis even when limited teaching resources are available. It reports on two half-day initiatives to teach quantitative methods that followed the principles of integration of method into a substantive course (as opposed to stand-alone course) and hands-on approach (as opposed to using a theoretical and hands-off approach).

Design/methodology/approach
Over the course of three semesters, 92 students that took part of the sessions answered a survey where they reported their basic understanding, confidence, practical abilities and anxiety with quantitative methods.

Findings
The results indicate significant improvements in self-reported basic understanding, confidence, practical abilities and anxiety. Further analysis indicated that neither gender nor previous statistical background had an impact on perceived benefit with the initiative.

Practical implications
In all, the study indicates that integration and hands-on approaches may be beneficial to reduce anxiety and increase confidence with quantitative data analysis, even when this initiative is limited in time and resources.

Originality/value
The study presents an approach to reducing anxiety and increasing confidence with quantitative data analysis. Teaching initiatives like this may be beneficial in situations when students experience high levels of statistics anxiety.
Current state and future potential of logistics and supply chain education: a literature review
Authors: Sun Luoyi , Song Guang 
Published: September 2018

PurposeThe purpose of this paper is threefold. First, it describes the general characteristics of studies on logistics and supply chain education (L&SCE). Second, it classifies identified papers on the basis of their main research methods and issues. Finally, it proposes some meaningful directions for future research.Design/methodology/approachSeventy-three papers published since 2000 in international peer-reviewed journals were reviewed using a systematic review methodology. The collected papers were analyzed and classified on the basis of research methods and issues.FindingsIt was found that most papers on L&SCE were published in journals in the logistics and supply chain management field and were conducted by either a single or mixed-method approach. The survey-based approach was the most preferred method. The contribution of this study is twofold. First, the identification of the five competencies and 49 skills required of logistics and supply chain talents was performed along with the analysis of the 42 courses and the teaching methods. Second, this study revealed some important aspects that have received inadequate attention in the literature and proposed potential research directions.Originality/valueThis paper provides academics and practitioners alike with a guide to extant literature. The proposed framework of the competencies and skills required of talents could be a guide to develop competence in both students and employees. The summary of the curriculum and the matrix of relationships between the relevant courses and competencies can be used by educators to improve L&SCE. Finally, the proposed research directions are meaningful for academics.
A model checking approach for user relationship management in the social network
Authors: Souri Alireza , Nourozi Monire , Rahmani Amir Masoud , Jafari Navimipour Nima 
Published: September 2018

Purpose
The purpose of this paper is to describe how formal verification strategies have been utilized to assess the correctness of Knowledge Creation Process (KCP) in the social systems. This paper analyzes a User Relationship Management (URM) approach in term of human behavior connection in the social systems. A formal framework is displayed for the URM which consolidates behavioral demonstrating strategy.

Design/methodology/approach
Evaluating the human behavior interactions is an important matter in the social systems. For this analysis, formal verification is an essential section in the complex information systems development. Model checking results satisfied the logical problems in the proposed behavior model analysis.

Findings
Model checking results represent satisfaction of the logical problems in the proposed behavior model analysis. In the statistical testing, the proposed URM mechanism supported KCP conditions. Also, the percentage of state reachability in the URM with KCP conditions is higher than the URM mechanism without supporting KCP conditions.

Originality/value
The model checking results show that the proposed URM mechanism with supporting the KCP conditions satisfies comprehensively behavioral interactions rather than the mechanism without KCP conditions in the social networks.
Beneficiary effect of a-lipoic acid supplementation on C-reactive protein level among adults
Authors: Fatahi Somaye , Kord Varkaneh Hamed , Teymouri Alireza , Azadbakht Leila 
Published: September 2018

PurposeClinical evidence has suggested that alpha-lipoic acid (ALA), a potent antioxidant, seems to have some effects on inflammatory process. However, these results are equivocal. The purpose of this paper is to investigate the nature of association between ALA and serum C-reactive protein (CRP) level by pooling the results from clinical trial studies.Design/methodology/approachRelevant studies were identified by systematic literature search of PubMed/MEDLINE, Scopus, Web of Sciences and Cochrane library up to September 2016 for randomized controlled trials (RCTs) evaluating the impact of ALA supplementation on CRP. The pooled data were summarized as weighted mean difference (WMD) and 95 per cent confidence interval (CI). Effect sizes of eligible studies were pooled using random- or fixed-effects (the DerSimonian–Laird estimator) depending on the results of heterogeneity tests.FindingsOf 212 papers, 15 were eligible RCTs according to inclusion criteria. The selected studies comprised 1,408 cases and 457 controls. The dose of ALA supplement ranged from 300 to 1,200 mg, and the duration of follow-up was from 1 to 48 weeks. ALA supplementation significantly reduced the levels of circulating CRP (WMD: −0.088, 95 per cent CI: −0.131, −0.045,p< 0.001) with significant heterogeneity (I2= 73.4 per cent,p< 0.001). Populations with age younger than 50 years (PMD: −0.060 mg/dl), receiving doses less than 600 mg/day (PMD: −0.057 mg/dl), having cardiovascular disease (PMD: −0.105 mg/dl), hemodialysis (PMD: −0.209 mg/dl), diabetes (PMD: −0.021 mg/dl) and otherwise healthy subjects (PMD: −0.045 mg/dl) were sources of heterogeneity.Originality/ValueThis meta-analysis of RCTs suggests that ALA supplementation seems to significantly reduce circulating CRP level.
A meta-analysis of service quality of Iranian university libraries based on the LibQUAL model
Authors: Ramezani Aboozar , Ghazimirsaeed Seyed Javad , Azadeh Fereydoon , Bandboni Mohammad Esmaeilpour , YektaKooshali Mohammad Hossein 
Published: September 2018

Purpose
The purpose of this paper is to assess the quality of Iranian university libraries.

Design/methodology/approach
This first systematic review and meta-analysis were based on the PRISMA guidelines by searching in national and international databases from 2003 to January 2017 with standard Persian and English keywords. Data searching, extracting and quality appraising were completed by two researchers, independently. Any unexpected documents were assessed by a third expert researcher. Data were extracted in accordance with the “Strength of the Reporting of Observational Studies in Epidemiology” checklist after the final selection of appraised documents. Random effects size based on Cochrane test and I2 were used for combining the obtained results from different studies together by considering the heterogeneity of studies.

Findings
Based on the meta-analysis conducted in 25 (6.42 percent) included studies, the total sample size was estimated. According to three dimensions of LibQUAL, findings of current information control, affect of service and the library as a place were estimated as 5.37 [CI95%: 5.02, 5.73], 6.91 [CI95%: 5.56, 6.26], and 5.46 percent [CI95%: 5.2, 5.73], respectively. Also, mean of service adequacy and superiority gap are equal to 0.07 [CI95%: −0.22, 0.36] and −2.06 [CI95%: −2.89, −1.23], respectively. There was a significant correlation between three dimensions of service quality and service superiority gap of LibQUAL and geographical regions of Iran (p<0.01). Also, a significant correlation was found between the gaps of services and three aspects of LibQUAL model and published years through a meta-regression test (p<0.01).

Practical implications
The results obtained from the present study showed that users are relatively satisfied with the quality of services provided by Iranian university libraries. An improvement in the quality of library services can promote the scientific level of universities.

Originality/value
The results of the present systematic review and meta-analysis study demonstrate a vital connection between primary research studies and decision-making for policymakers in Iranian university libraries to increase quality services.
Microstructure of Sn-20In-2.8Ag solder and mechanical properties of joint with Cu
Authors: Peng Fen , Liu Wensheng , Ma Yunzhu , Liang Chaoping , Huang Yufeng , Tang Siwei 
Published: September 2018

Purpose
To explore substitutes for traditional Sn-Pb solder, Sn-20In-2.8Ag was considered because of its appropriate melting temperature, good reliability and high ductility at less than 100°C. However, the mechanical properties of Sn-20In-2.8Ag were not satisfactory. The reason for the poor mechanical properties of the Sn-20In-2.8Ag/Cu joint was revealed, and a way to solve the problem was found.

Design/methodology/approach
The microstructure evolution, characteristics of melting and solidification and joining performance with Cu were investigated using scanning electron microscopy (SEM), electron probe microanalysis, differential scanning calorimetry (DSC) and mechanical testing.

Findings
SEM results showed that the microstructure of Sn-20In-2.8Ag was composed of coarse dendritic Ag2In and γ phases, with Ag2In distributed at the grain boundaries. DSC measurements revealed that small amount of low temperature eutectic reaction, L → Ag2In + β + γ, occurred at 112.9°C. This reaction was caused by the segregation of indium, which is a process that has a strong driving force. In the lap-shear testing, a crack propagated along the grain boundary of the solder, and failure showed an intergranular fracture. This failure was connected with the three-phase eutectic and coarse Ag2In. Thus, to improve the mechanical properties, segregation of indium should be reduced and coarsening of Ag2In should be prevented.

Originality/value
The reason for the unsatisfactory mechanical properties of Sn-20In-2.8Ag was revealed via microstructural observations and solidification analysis, and the way to solve this problem was found.
Dying Quietly: English Suburbs and the Stiff Upper Lip
Authors: Dorling Danny 
Published: September 2018

AbstractThe English suburbs are dying. Years of austerity have slowly changed the landscape. Poverty is now common in the suburbs. Since 2014, life expectancy has been falling across most of England, especially in the suburbs. Now infant mortality rates are also rising year on year (unlike anywhere else in Europe). In hindsight it is not surprising that the majority of suburban English people voted Brexit, most noticeably in the Home Counties. Middle England is understandably angry. No more fortitude in the face of adversity and the hiding of emotions. The stiff up lip has slipped. Change is in the air.