bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Hybrid Nanovector of Suicide Gene Engineered Lentivirus Coated with Bioreducible Polyaminoglycosides for Enhancing Therapeutic Efficacy against Glioma
Authors: Fan Wenhua , Shao Meiyu , Zhang Junwen , Jin Guishan , Liu Fusheng , Xu Fu‐Jian 
Published: January 2019

AbstractAn emerging hybrid nanovector integrating the merits of both viral and nonviral vectors has attracted much attention as the next generation of promising gene vectors to overcome the primary challenge of cancer gene therapy. Due to its inherent advantages, lentivirus (Lv) has been increasingly applied and investigated in medical fields. Herein, a new hybrid nanovector (SS‐HPT/Lv) composed of the Lv core and reduction‐responsive hyperbranched polyaminoglycoside (SS‐HPT) shell is designed via electrostatic interaction. In comparison with polybrene (commercial enhanced transfection reagent), SS‐HPT endows the hybrid nanovector with better biosafety. Furthermore, both the appropriate nanoparticle sizes and positive surface potentials contribute to the endocytosis and rescue of SS‐HPT/Lv from endocytic vesicles. Regarding therapeutic application, lentiviral vector acquires permanent transgene expression with the capability of integrating to the host chromosome, and SS‐HPT/Lv exhibits an improved transduction efficacy. The cytosine deaminase/5‐fluorocytosine suicide gene therapy system mediated by SS‐HPT/Lv performs an enhanced antitumor efficiency and extends the survival time of glioma‐bearing rats. Such a hybrid nanovector strategy would open a new avenue to the development of gene vectors for treating malignant cancers.
Studies of Functional Defects for Fast Na‐Ion Conduction in Na3−yPS4−xClx with a Combined Experimental and Computational Approach
Authors: Feng Xuyong , Chien Po‐Hsiu , Zhu Zhuoying , Chu Iek‐Heng , Wang Pengbo , Immediato‐Scuotto Marcello , Arabzadeh Hesam , Ong Shyue Ping , Hu Yan‐Yan 
Published: January 2019

AbstractAll‐solid‐state rechargeable sodium (Na)‐ion batteries are promising for inexpensive and high‐energy‐density large‐scale energy storage. In this contribution, new Na solid electrolytes, Na3−yPS4−xClx, are synthesized with a strategic approach, which allows maximum substitution of Cl for S (x = 0.2) without significant compromise of structural integrity or Na deficiency. A maximum conductivity of 1.96 mS cm−1 at 25 °C is achieved for Na3.0PS3.8Cl0.2, which is two orders of magnitude higher compared with that of tetragonal Na3PS4 (t‐Na3PS4). The activation energy (Ea) is determined to be 0.19 eV. Ab initio molecular dynamics simulations shed light on the merit of maximizing Cl‐doping while maintaining low Na deficiency in enhanced Na‐ion conduction. Solid‐state nuclear magnetic resonance (NMR) characterizations confirm the successful substitution of Cl for S and the resulting change of P oxidation state from 5+ to 4+, which is also verified by spin moment analysis. Ion transport pathways are determined with a tracer‐exchange NMR method. The functional detects that promote Na ‐ion transport are maximized for further improvement in ionic conductivity. Full‐cell performance is demonstrated using Na/Na3.0PS3.8Cl0.2/Na3V2(PO4)3 with a reversible capacity of ≈100 mAh g‐1 at room temperature.
Protein‐Induced Shape Control of Noble Metal Nanoparticles
Authors: Chakraborty Indranath , Parak Wolfgang J. 
Published: January 2019

AbstractShape control of nanoparticles results in tuned optical properties which are indeed beneficial for different bio‐based applications. Shape controls in major cases, governed by toxic surfactants or harsh solvent conditions. To avoid the toxicity of surfactants used as shape controlling agent, different bio‐inspired synthesis of noble metal nanoparticles are developed. Proteins play a significant role here to create anisotropic nanoparticles without the use of any toxic surfactants. Various shape and size of nanoparticles are developed so far based on proteins. This progress report summarizes such protein‐induced shape controls of different noble metal nanoparticles and explain the recent understandings of this method from mechanistic point of view. The report also explains the new opportunities in this direction in near future.
Investigating Free Charge‐Carrier Recombination in Organic LEDs Using Open‐Circuit Conditions
Authors: Wu Jinhan , Fischer Axel , Reineke Sebastian 
Published: January 2019

AbstractAlthough organic light‐emitting diodes (LEDs) are widely used in commercial applications, a comprehensive knowledge about the occurring recombination pathways is still absent. Especially access to the bandgap is needed to figure out which path the charge carriers take, key to further understand and optimize the latest generations of thin film LED technology. Here, state‐of‐the‐art organic LEDs are treated like solar cells by measuring the open‐circuit voltage under UV illumination. A variation of the illumination intensity and temperature gives access to the effective bandgap, the ideality factor and the recombination strength. A differential evaluation approach is implemented, yielding the full temperature and intensity dependence of these parameters. A radiative and a non‐radiative recombination process are identified and used to reconstruct the current density dependence of the external quantum efficiency. All recombination events are related to an effective bandgap that suggests free charge recombination between the guest and the host material of the emission layer. This approach will thus help to identify and eliminate non‐radiative recombination losses in LEDs based on other type of molecules emitters and materials, such as perovskites or quantum dots, as well. Knowing the effective bandgap will also be essential to realize LEDs with the lowest possible driving voltages.
S‐Type Negative Differential Resistance in Semiconducting Transition‐Metal Dichalcogenides
Authors: Wang Miao , Wang Chen‐Yu , Wu Chenchen , Li Qiao , Pan Chen , Wang Cong , Liang Shi‐Jun , Miao Feng 
Published: January 2019

AbstractCurrent‐controlled (also known as “S‐type”) negative differential resistance (NDR) is of crucial importance to many emerging applications including neuromorphic computing and high‐density memristors integration. However, the experimental realization of S‐type NDR based on conventional mechanisms poses demanding requirements on materials, which greatly limits their potential applications. Here, it is experimentally identified that semiconducting transition‐metal dichalcogenides (TMDs) can host a bipolar S‐type NDR devices. Theoretical simulations indicate that the origin of the NDR in these devices arises from a thermal feedback mechanism. Furthermore, the potential applications of TMD‐based S‐type NDR device in signal processing and neuromorphic electronics are demonstrated.
Correlation between systemic inflammatory response and quality of life in patients with chronic rhinosinusitis
Authors: Orb Quinn , Pulsipher Abigail , Smith Kristine A. , Ashby Shaelene , Alt Jeremiah A. 
Published: January 2019

BackgroundLocal sinonasal inflammation resulting from altered T‐cell immune signaling is a contributor to the pathogenesis of chronic rhinosinusitis (CRS). CRS patients experience negative impacts on quality of life (QOL) and suffer from comorbidities linked to systemic inflammation. However, systemic inflammatory profiling to evaluate the association between systemic inflammation and QOL in CRS has not been performed. Our objectives were to compare local and systemic inflammatory gene expression in patients with CRS to determine if systemic markers of inflammation associate with disease severity and disease‐specific QOL.MethodsA prospective observational study was conducted comparing 16 patients with CRS to 10 controls. Inflammatory gene expression in the anterior ethmoid tissues and peripheral blood of patients was measured using multiplex gene expression analysis and correlated to disease severity (computed tomography and nasal endoscopy) and disease‐specific QOL (22‐item Sino‐Nasal Outcome Test [SNOT‐22] and Rhinosinusitis Disability Index) using linear regression analyses.ResultsPatients with CRS showed significant increases in the expression of ctla4 and jak1 in sinonasal tissue and blood (p < 0.05), whereas the gene expression of hla‐dqa1, hla‐dqb1, and dusp4 was significantly decreased in patients with CRS compared to controls (p < 0.05). Soluble and local ctla4 and jak1 showed a significant positive correlation with clinical markers of disease severity and disease‐specific QOL (p < 0.05).ConclusionLocal and systemic gene expression involved in T‐cell immune signaling was found to be significantly altered in the blood and sinonasal tissues of patients with CRS compared to controls and significantly correlated to disease severity and QOL in patients with CRS.
Herbal dry extract BNO 1011 improves clinical and mucociliary parameters in a rabbit model of chronic rhinosinusitis
Authors: Cho Do‐Yeon , Skinner Daniel , Mackey Calvin , Lampkin Harold B , Elder Jeffrey Brent , Lim Dong Jin , Zhang Shaoyan , McCormick Justin , Tearney Guillermo J. , Rowe Steven M. , Woodworth Bradford A. 
Published: January 2019

BackgroundEnhancing chloride (Cl–) secretion in sinus epithelia represents a novel therapeutic approach to chronic rhinosinusitis (CRS). Herbal dry extract BNO 1011 enhances mucociliary clearance (MCC) via upregulation of Cl– secretion in sinonasal cultures in vitro and murine epithelium in vivo. The objective of this study is to evaluate whether the BNO 1011 improves MCC and clinical parameters in a rabbit model of CRS.MethodsAfter the development of CRS in 30 New Zealand white rabbits, animals were randomly assigned to receive oral placebo (n = 10), BNO 1011 (low dose [LD], 25 mg/kg/daily) (n = 10), or BNO1011 (high dose [HD], 125 mg/kg/daily) (n = 10) for 4 weeks. Outcomes included sinus opacification (Kerschner's rabbit sinus CT grade), maxillary epithelial Cl− secretion (sinus potential difference [PD] assay), airway surface liquid (ASL) depth using micro‐optical coherence tomography (μOCT), and submucosal gland density (SMD) on histopathology. Outcome parameters were analyzed by 2 blinded investigators.ResultsBNO 1011 significantly cleared sinus opacification (HD = 1.21 ± 0.63, LD = 1.26 ± 0.37,) compared to placebo (4.02 ± 0.92) (p = 0.009). BNO 1011 resulted in markedly greater mean sinus PD polarization (HD = –12.23 ± 1.4 mV, LD = –12.0 ± 3.0 mV) when compared to rabbits treated with placebo (–4.1 ± 1.1 mV) (p = 0.03). ASL depth was significantly improved when treated with HD (4.08 ± 0.06 μm) and LD (4.05 ± 0.06 μm) compared to placebo (3.5 ± 0.05 μm) (post hoc analysis, p < 0.0001). Histologically, epithelial thickness (HD = 10.0 ± 0.7 μm; LD = 13.7 ± 0.9 μm; placebo = 21.1 ± 2.3 μm; p < 0.005), subepithelial thickness (HD = 63.1 ± 6.6 μm; LD = 103.2 ± 6.7 μm; placebo = 113.3 ± 6.0 μm; p < 0.001), and SMD (HD = 22.2 ± 2.9%; LD = 31.8 ± 1.1%; placebo = 43.8 ± 1.7%; p < 0.0001) were noticeably better with the HD.ConclusionHerbal dry extract BNO 1011 improves radiographic, histologic, and MCC parameters in a rabbit model of CRS.
Improved Transistor Performance by Modulating Molecular Packing with Donor and Acceptor Moieties
Authors: Yao Ze‐Fan , Liu Han‐Yu , Wang Zi‐Yuan , Zhou Ze‐Kun , Wang Jie‐Yu , Pei Jian 
Published: January 2019

AbstractThe joint of the donor and acceptor moieties allows a facile and effective strategy to develop novel organic conjugated materials. However, few pieces of work report the understanding of the donor–acceptor interactions at the molecular level. Herein, we developed three small molecules containing one acceptor motif with different amounts of the donor unit. By combining theoretical calculations and energy level characterization, the lowest unoccupied molecular orbital (LUMO) levels of the three molecules were proven to be almost identical. The molecular packing modes were evaluated from crystal structure prediction. Owing to the donor–acceptor interactions, the packing mode can be tuned from a 1D slipped stacking to a 2D brick layer. The 2D molecular packing and charge transport channel endowed the materials a higher electron mobility of 3.29 cm2 V−1 s−1 in the single‐crystal field‐effect transistors after such modulation.
A graphical approach for stability and robustness analysis in commensurate and incommensurate fractional‐order systems
Authors: Shen Yaohua , Wang Yunjian , Yuan Nana 
Published: January 2019

AbstractIn this paper, a novel graphical approach for stability and robustness analysis in commensurate and incommensurate fractional‐order systems (FOS) is proposed. The approach can determine zero distribution of system characteristic equations with commensurate and incommensurate fractional‐orders in right‐half plane (RHP) and imaginary axis in the complex plane. The approach proposed is derived and generalizd from Routh‐type test for polynomials with the commensurate fractional and integer orders. In addition, the novel graphical approach can treat robustness issues of some certain systems. Furthermore, some examples are given to demonstrate the effectiveness of the approach. Finally, a proof is given to verify the correctness of the criterion.
Sustainable, Dendrite Free Lithium‐Metal Electrode Cycling Achieved with Polymer Composite Electrolytes Based on a Poly(Ionic Liquid) Host
Authors: Girard Gaetan M. A. , Wang Xiaoen , Yunis Ruhamah , MacFarlane Douglas R. , Bhattacharyya Aninda J. , Forsyth Maria , Howlett Patrick C. 
Published: January 2019

AbstractPolymer composite solid‐state electrolyte materials based on ionic liquids stand out as viable alternatives to flammable liquid electrolytes for solid state lithium‐metal batteries. They offer a compromise between favourable mechanical properties and stability against Li‐metal, coupled with favourable ion transport. However, insufficient Li+ transport properties for practical battery operation may result from the higher mobility of other ionic species from the ionic liquid (IL). Here, this issue was addressed by confining a highly concentrated IL electrolyte in a poly(ionic liquid) matrix with the addition of 5 wt % of alumina nanoparticles; these superconcentrated IL electrolytes favour Li+ ion transport. The composites are based on a poly(diallyldimethylammonium) bis(trifluoromethanesulfonyl)imide (PDADMA NTf2) matrix, and an electrolyte solution (ES) of high lithium concentration phosphonium IL, trimethyl(isobutyl)phosphonium bis(fluorosulfonyl)imide (P111i4FSI), with 3.8 mol kg−1 (3.8 m) LiFSI. The impact of ES content within the composite on Li+ transference number and electrochemical stability against Li‐metal is reported. For the 50 wt % ES and 50 wt % of PDADMA NTf2 composite, up to 0.5 mAh cm−2 of Li‐metal plating/stripping for over 20 days at 50 °C is shown. Scanning electron microscopy (SEM) confirmed that no Li dendrite formation was visible at the Li‐metal/polymer composite interface. Competitive performance of LiFePO4 electrodes (1.2 mAh cm−2) is also reported.
Dysmorphic contribution of neurotransmitter and neuroendocrine system polymorphisms to subtherapeutic mood states
Authors: Gonzalez Irene , Polvillo Rocio , Ruiz‐Galdon Maximiliano , Reyes‐Engel Armando , Royo Jose Luis 
Published: January 2019

AbstractObjectiveFrom an evolutionary perspective, emotions emerged as rapid adaptive reactions that increase survival rates. Current psychobiology includes the consideration that genetic changes affecting neuroendocrine and neurotransmission pathways may also be affecting mood states. Following this hypothesis, abnormal levels of any of the aminergic neurotransmitters would be of considerable importance in the development of a pathophysiological state.Materials and MethodsA total of 668 students from the School of Medicine of the University of Malaga (Average = 22.41 ± 3; 41% men) provided self‐report measures of mood states using POMS and GHQ‐28 questionnaires and buccal cells for genotyping 19 polymorphisms from 14 selected neurotransmitter pathways genes (HTR1A; HTR2A; HTR2C; HTR3B; TPH1; SLC18A1; SLC18A2; COMT; MAOA; MAOB) and neuroendocrine system (AVPR1B; OPRM1; BDNF; OXTR).ResultsMAOA rs3788862 genotype correlates with decreasing levels of Tension among females (beta = −0.168, p‐value = 0.003) but it is neutral among males in this subscale. On the contrary, it correlates with lower GHQ‐28 depression scores among males (beta = −0.196, p‐value = 0.008). Equivalently, SLC18A1 and HTR2A variants correlated with anger and vigor scores, only among males. From the neuroendocrine system, OPRM1 rs1799971 correlated increasing levels of female's Anxiety, depression and Social Dysfunction scores.ConclusionOur findings suggest that these polymorphisms contribute to define general population mood levels, although exhibiting a clear sexual dimorphism.
Association between miRNAs expression and cognitive performances of Pediatric Multiple Sclerosis patients: A pilot study
Authors: Liguori Maria , Nuzziello Nicoletta , Simone Marta , Amoroso Nicola , Viterbo Rosa Gemma , Tangaro Sabina , Consiglio Arianna , Giordano Paola , Bellotti Roberto , Trojano Maria 
Published: January 2019

Abstract
Introduction
The Pediatric onset of Multiple Sclerosis (PedMS) occurs in up to 10% of all cases. Cognitive impairment is one of the frequent symptoms, exerting severe impact in patients’ quality of life and school performances. The underlying pathogenic mechanisms are not fully understood, and molecular markers predictive of cognitive dysfunctions need to be identified. On these grounds, we searched for molecular signature/s (i.e., miRNAs and target genes) associated with cognitive impairment in a selected population of PedMS patients. Additionally, changes of their regional brain volumes associated with the miRNAs of interest were investigated.MethodsNineteen PedMS subjects received a full cognitive evaluation; total RNA from peripheral blood samples was processed by next‐generation sequencing followed by a bioinformatics/biostatistics analysis.ResultsThe expression of 11 miRNAs significantly correlated with the scores obtained at different cognitive tests; among the others, eight miRNAs correlated with the Trail Making Tests. The computational target prediction identified 337 genes targeted by the miRNAs of interest; a tangled network of molecular connections was hypothesized, where genes like BST1, NTNG2, SPTB, and STAB1, already associated with cognitive dysfunctions, were nodes of the net. Furthermore, the expression of some miRNAs significantly correlated with cerebral volumes, for example, four miRNAs with the cerebellum cortex.ConclusionsAs far as we know, this is the first evaluation exploring miRNAs in the cognitive performances of PedMS. Although none of these results survived the multiple tests’ corrections, we believe that they may represent a step forward the identification of biomarkers useful for monitoring and targeting the onset/progression of cognitive impairments in MS.
Organizational mindfulness, mindful organizing, and environmental and resource sustainability
Authors: Ndubisi Nelson Oly , Al‐Shuridah Obaid 
Published: January 2019

AbstractThe research theorizes that environmental vulnerability can be minimized through mindfulness‐based strategies, and redesigning organizing processes, so that richer thinking is activated more quickly among greater number of people all of whom try to update their knowledge regardless of the knowledge source. It empirically evaluates the effects of organizational mindfulness and mindful organizing on resources and environmental sustainability. The model was tested in a very appropriate setting—Saudi Arabia, where increasing demand for and supply of energy culminates in unsustainable resources utilization and rise in greenhouse gas emissions and other environmental vulnerabilities. Data were collected from Saudi firms operating in the oil and gas sector and analyzed using SmartPLS software. The measurement and structural models were evaluated.The measurement model exhibits adequate model fit. The tests for the structural models show that four (of five) dimensions of organizational mindfulness (viz., commitment to resilience, deference to expertise, preoccupation with failure, and reluctance to simplify interpretations) and mindful organizing are significantly related at 5% significance level. Sensitivity to operations has no significant relationship with mindful organizing. Mindful organizing is significantly related to environmental and resources sustainability. Moreover, mindful organizing fully or partially mediates in the relationship between some of the dimensions of organizational mindfulness and environmental and resources sustainability. The study is one of the first to integrate mindfulness‐based approaches to sustainability and environmental research.
Improved survival with radiotherapy in hepatocellular carcinoma with major vascular invasion: A propensity‐matched analysis of Surveillance, Epidemiology, and End Results database
Authors: Lin Qiuyan , Huang Xiaoquan , Zhong Canmei , Luo Tiancheng , Zeng Xiaoqing , Chen Shiyao 
Published: January 2019

AbstractObjectivesHepatocellular carcinoma (HCC) associated with major vascular invasion is an advanced stage disease with an extremely poor prognosis and low survival rate. Our study evaluated the survival benefit of radiotherapy (RT) in HCC patients with major vascular invasion through Surveillance, Epidemiology, and End Results database.MethodsWe analyzed 3181 HCC patients with major vascular invasion cases diagnosed from 2004 to 2013. Patients (N = 308) who underwent RT and patients (N = 2873) who did not receive RT were compared. We successfully analyzed patients using propensity score matching (PSM). Kaplan‐Meier and Cox‐regression analyses were applied to assess prognosis.ResultsThe median survival time in radiation‐treated group was longer compared to the control group (7 months vs 3 months; P < 0.001) in the overall sample and 3 months longer compared to the control group (7 months vs 4 months; P < 0.001) in a PSM cohort. Cox‐regression analyses showed that radiation‐treated patients in propensity‐matched sample had a significantly lower risk of mortality (HR: 0.625, 95% CI: 0.522‐0.749, P < 0.001) compared with untreated patients. The radiation‐treated groups had better survival rate than untreated group. Subgroup analysis revealed that the survival time of patients in radiation‐treated group was significantly longer than that in the untreated group (P < 0.001 and P = 0.026, respectively). The subgroup analysis also revealed that RT provides a survival benefit regardless of race, marital status, and tumor size after PSM.ConclusionsRadiotherapy provides improves survival in HCC patients with major vascular invasion, especially for tumor(s) confined to one lobe and not on surface of liver.
MCCK1 enhances the anticancer effect of temozolomide in attenuating the invasion, migration and epithelial‐mesenchymal transition of glioblastoma cells in vitro and in vivo
Authors: Liu Tie , Li Anqi , Xu Yulun , Xin Yu 
Published: January 2019

AbstractChemotherapy with temozolomide (TMZ) is the traditional treatment for glioblastoma (GBM). Nevertheless, majority of GBM patients have recurrence from resistance to the chemotherapy. Herein, we examined combinational effects of MCCK1 (a specific and effective IKKε inhibitor) with TMZ in GBM U251MG and U‐87MG cell lines as well as U251MG xenograft models to overcome the therapeutic limitation of chemotherapy for GBM. Although MCCK1 alone showed inhibitory effects on in vitro proliferation, migration, invasion, and EMT of U251MG and U‐87MG cells, combination of MCCK1 and TMZ showed enhanced inhibitory effects. In the U251MG GBM xenograft models, MCCK1 showed synergistic therapeutic effects in combination with TMZ to reduce tumor volumes significantly. These data indicated that MCCK1 could be a candidate sensitizer to potentiate therapeutic effects of conventional cytotoxic treatment for GBM.