bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medroxyprogesterone reverses tolerable dose metformin-induced inhibition of invasion via matrix metallopeptidase-9 and transforming growth factor-β1 in KLE endometrial cancer cells
Authors: Suh Dong Hoon , Lee Sunray , Park Hyun-Sook , Park Noh Hyun 
Published: April 2019

AbstractThis study was performed to evaluate the anticancer effects of tolerable doses of metformin with or without medroxyprogesterone (MPA) in endometrial cancer cells. Cell viability, cell invasion, and levels of matrix metallopeptidase (MMP) and transforming growth factor (TGF)-β1 were analyzed using three human endometrial adenocarcinoma cell lines (Ishikawa, KLE, and USPC) after treatment with different dose combinations of MPA (0, 10 μM) and metformin (0, 100, 1000 μM). Combining metformin (0, 100, 1000 μM) and 10 μM MPA induced significantly decreased cell viability in a time- and dose-dependent manner in Ishikawa cells, but not in KLE and USPC cells. There was no dose- or time-dependent cell growth inhibition, or positive western blot results for the expression of progesterone receptors and phospho-AMPKa, following treatment with any combination of metformin (0, 100, 1000 μM) and 10 μM MPA in KLE and USPC cells. In KLE cells, metformin treatment alone significantly inhibited cell invasion in a dose-dependent manner (1.31±0.05, 0.94±0.04, 0.83±0.05 at 0, 100 μM, 1000 μM, respectively; p<0.0005). The inhibitory effect of metformin was reversed to create a stimulating effect when metformin was combined with 10 μM MPA (1.10±0.05, 1.42±0.18, 1.41±0.26 at 0, 100, 1000 μM, respectively; p<0.005). MMP-9 and TGF-β1 showed similar trends in terms of cell invasion in KLE cells. In conclusion, the anti-invasive effect of metformin in KLE cells was completely reversed to the state of no treatment by the addition of MPA; this might be mediated through MMP-9 and TGF-β1. Our study suggests the possibility of these combinations doing harm, rather than good, under some conditions.
Temporary anosmia in mice following nasal lavage with dilute detergent solution
Authors: Mast Thomas Gerald , Zuk Kelsey , Rinke Andrew , Quasem Khaleel , Savard Bradley , Brobbey Charles , Reiss Jacob , Dryden Michael 
Published: April 2019

AbstractOlfactory sensory deprivation induces anosmia and reduces tyrosine hydroxylase and dopamine levels in the olfactory bulb. The behavioral consequences specific to the loss of olfactory bulb dopamine are difficult to determine because sensory deprivation protocols are either confounded by side effects or leave the animal anosmic. A new method to both induce sensory deprivation and to measure the behavioral and circuit consequences is needed. We developed a novel, recoverable anosmia protocol utilizing nasal lavage with a dilute detergent solution. Detergent treatment did not damage the olfactory epithelium as measured by scanning electron microscopy, alcian blue histology, and acetylated tubulin immunohistochemistry. One treatment induced anosmia that lasted 24-48 hours. Lastly, five days of treatment reduced both olfactory bulb tyrosine hydroxylase and dopamine levels which indicates that anosmia persists between treatments. This is the first report of a sensory deprivation protocol that induces recoverable anosmia and can be paired with biochemical, histological, and behavioral investigations of olfaction.
Temporal gating of SIRT1 functions by O-GlcNAcylation prevents hyperglycemia and enables physiological transitions in liver
Authors: Chattopadhyay Tandrika , Maniyadath Babukrishna , Bagul Hema P , Chakraborty Arindam , Shukla Namrata , Budnar Srikanth , Kolthur-Seetharam Ullas 
Published: April 2019

SummaryInefficient fasted-to-refed transitions are known to cause metabolic diseases. Thus, identifying mechanisms that may constitute molecular switches during such physiological transitions become crucial. Specifically, whether nutrients program a relay of interactions in master regulators, such as SIRT1, and affect their stability is underexplored. Here, we elucidate nutrient-dependent O-GlcNAcylation of SIRT1, within its N-terminal domain, as a key determinant of hepatic glucose- and fat-metabolism, and insulin signaling. SIRT1 glycosylation dictates interactions with PPARα/FOXO1/PGC1α/SREBP1, to exert a temporal control over transcription of genes during fasted-to-refed transitions. Interestingly, glycosylation-dependent cytosolic export of SIRT1 promotes a transient interaction with AKT and subsequent proteasomal degradation. Loss of glycosylation discomposes these interactions and enhances stability of SIRT1 even upon refeeding, which causes insulin resistance, hyperglycemia and hepatic-inflammation. Aberrant glycosylation of SIRT1 is associated with aging and/or metabolic diseases. Thus, nutrient-dependent glycosylation constrains spatio-temporal dynamics of SIRT1 and gates its functions to maintain metabolic homeostasis.
Rational and symbolic uses of performance measurement
Authors: Dobija Dorota , Górska Anna Maria , Grossi Giuseppe , Strzelczyk Wojciech 
Published: April 2019

PurposeThe purpose of this paper is to facilitate a deeper understanding of the uses and users of performance measurement (PM) in the university context.Design/methodology/approachEmpirical data were gathered from four universities. This approach allows for a multilevel and comparative analysis based on the neo-institutional theory. The results are discussed alongside interdisciplinary literature on the use of PM in the public sector.FindingsPM practices at universities have become increasingly popular on institutional, organisational and individual levels. The results indicate that different types of PM are used in universities and that the extent, and scope of PM used by various actors differ. Universities often use PM in a ceremonial and symbolic manner, with the aim of legitimising themselves externally as research-oriented institutions. The use of PM depends on both, exogenous factors (such as isomorphic pressures) and endogenous factors related to the different responses of organisations and individual actors (university managers, and academics). However, the analysis at the internal level reveals different attitudes and some resistance to the use of such kinds of PM. In universities with a local focus, the use of PM for rational decision-making is generally loosely coupled with the reporting performance for external accountability purposes. Moreover, the internal use of PM can be also symbolic.Research limitations/implicationsThis paper focusses on four case studies that are currently undergoing changes. The comparative analysis is supported by the use of different data collection methods and several in-depth interviews with key university actors.Originality/valueThe authors assume that the use of PM depends on a number of exogenous and endogenous factors. PM uses and users are discussed in the specific context of the higher education system in Poland. The four business school cases facilitate a comparative analysis of the similarities and differences in terms of the uses and users of PM in the context of internationally and locally oriented universities.
Corporate-level strategy and firm performance: evidence from China
Authors: Li Boya , Chen Shou 
Published: April 2019

PurposeThe research interest in this paper is primarily in the question of how important changes in corporate-level strategy affect firm performance. This paper aims to explore the relationship between strategic change and performance, illustrate the frequency patterns of major strategic changes and assess the multi-period performance implications of major strategic changes.Design/methodology/approachThis paper defines strategic change by combining contingency theory and resource-based view. The panel data from 1973 listed firms of China’s A-share market that reported data between the years 2004 and 2015 are selected as the sample to test various relationships and effects between performance and strategic change.FindingsThis paper empirically shows that change in strategies benefits subsequent firm performance, specifically resources re-allocation among existing businesses will result better performance, and successful firms exhibit less strategic change than those performing poorly. It also demonstrates that, in China, the effects of a major strategic change on subsequent performance peaks after one year, but starts to decline thereafter.Originality/valueThis paper explores whether changes, especially important changes, in corporate-level strategy influence subsequent firm performance, and illustrates how frequently a listed firm in China makes decisions about corporate-level strategy. It contributes empirically to the literature by providing one of the first empirical evidence on assessing the effects of important changes in corporate-level strategy on performance.
The changing role of the salesperson: how should salespeople act today?
Authors: Castro-González Sandra , Bande Belén 
Published: April 2019

Purpose
The purpose of this paper is to highlight the nature and the organizational role of salespeople and, in particular, underscore the change in salespeople’s management in the current business context.

Design/methodology/approach
The paper briefly explains the role of salespeople in an organization and how salespeople are gaining prominence in customer management. From this point of view, the paper suggests steps to achieve the sale.

Findings
It is evident that salespeople must change the way they achieve sales goals within the organization. Currently, they need to adopt a more customer-centric approach, and the paper suggests how to do this.

Practical implications
The paper aims to provide key points for understanding and managing the sales force within the organization. Findings are relevant for those who must manage these workers or those who simply want to know more about the characteristics of the sales force.

Originality/value
The paper highlights the importance of salespeople in organizations and describes how they should be managed. In addition, in some ways, the paper helps improve readers’ perception of the sales position.
Dynamic changes of governance mechanisms in mega construction projects in China
Authors: Wang Dedong , Fang Shaoze , Li Kaili 
Published: April 2019

PurposeThe purpose of this paper is to study the mechanisms governing dynamic changes in relational and contractual governance at different stages of government-funded mega construction projects (MCPs) by studying their different effects on project performance and participants’ opportunism.Design/methodology/approachPartial least squares structural equation modeling was used to test eight hypotheses based on data collected from 147 respondents in different participating organizations in Chinese MCPs.FindingsFirst, contractual governance has a stronger positive impact on project performance than relational governance in the early stage of MCPs, while relational governance exerts more positive effects on project performance than contractual governance in the middle and late stages. Second, opportunism is a mediator variable between governance mechanisms and project performance, and relational governance is more effective than contractual governance in restricting opportunism.Originality/valueIn contrast to a static analysis of project governance mechanisms, this study examines dynamic changes in the governance mechanisms of MCPs in the Chinese context by considering the mediating role of opportunism as well as guanxi as an element of relational governance, thus filling in gaps in the literature on MCP governance and contributing to the development of MCP management theory.
Training and development in small professional services firms
Authors: Susomrith Pattanee , Coetzer Alan , Ampofo Emmanuel 
Published: April 2019

PurposeThis paper aims to examine whether participation in training and development (T&D) events is associated with employees’ affective commitment and propensity to enact innovative behaviours in small professional services firms. The study also investigates associations between both attitudes towards T&D and policy and practice supportive of T&D and levels of participation in T&D events.Design/methodology/approachData from 203 employees in small professional services firms employing 50 or fewer staff were analysed using regression analysis and PROCESS macro.FindingsOnly policy and practice supportive of T&D was associated with participation levels. Participation in T&D events was positively related to affective commitment. Furthermore, employees who participated in more T&D events were more likely to enact innovative behaviours, while affective commitment mediated the positive relationship between number of T&D events attended and innovative behaviours. Contrary to expectations, neither participation in just training nor participation in just development was associated with either attitudes or behaviours.Practical implicationsThe findings have important implications for small firms which tend to rely on wholly work-based experiences for the development of employees’ knowledge and skills. Such an approach to learning for work may inadvertently shape a workforce that lacks commitment to the organisation and that has a diminished capacity for innovative behaviours.Originality/valueThere is limited research on how T&D affects attitudes and behaviours in small firms. Large and small firms are fundamentally different, thus findings from studies in large firms may not extend to small firms.
Use of multi-lexicons to analyse semantic features for summarization of touring reviews
Authors: Wang Hei Chia , Chiang Yu Hung , Sun Yi Feng 
Published: April 2019

Purpose
This paper aims to improve a sentiment analysis (SA) system to help users (i.e. customers or hotel managers) understand hotel evaluations. There are three main purposes in this paper: designing an unsupervised method for extracting online Chinese features and opinion pairs, distinguishing different intensities of polarity in opinion words and examining the changes in polarity in the time series.

Design/methodology/approach
In this paper, a review analysis system is proposed to automatically capture feature opinions experienced by other tourists presented in the review documents. In the system, a feature-level SA is designed to determine the polarity of these features. Moreover, an unsupervised method using a part-of-speech pattern clarification query and multi-lexicons SA to summarize all Chinese reviews is adopted.

Findings
The authors expect this method to help travellers search for what they want and make decisions more efficiently. The experimental results show the F-measure of the proposed method to be 0.628. It thus outperforms the methods used in previous studies.

Originality/value
The study is useful for travellers who want to quickly retrieve and summarize helpful information from the pool of messy hotel reviews. Meanwhile, the system will assist hotel managers to comprehensively understand service qualities with which guests are satisfied or dissatisfied.
The role of practical assessment in the delivery of successful enterprise education
Authors: Murray Alan 
Published: April 2019

PurposeThe purpose of this paper is to concentrate on how assessment is used to support the aims of enterprise education leading to recommendations for improvements to the current approach to the assessment of enterprise.Design/methodology/approachThis paper presents a review of entrepreneurship education literature and a qualitative case study conducted on a sample of enterprise educators at University of the West of Scotland. Data were analysed using thematic analysis.FindingsParadoxically, the traditional enterprise education paradigm harms that which it attempts to nurture: entrepreneurial thinking and activity. The rationalised approach to education conflicts with the aims of enterprise educators, and there is evidence of a visible and growing disconnect between academia (the theory) and industry (the practice).Research limitations/implicationsThe work is limited as it concentrates on a single case study. The qualitative approach focusses on a specific social field and therefore the findings cannot be generalised to other settings. These limitations can be addressed in future research.Practical implicationsThis work has resonance for enterprise educators delivering and assessing entrepreneurial learning in an academic setting and will also be of interest to decision makers within this sector concerned with ensuring academic practice remains aligned to policy and industry requirements.Originality/valueEnterprise education is well researched; however, there is a gap in the area of enterprise assessment which is under researched and not well understood.
The central role of customer dialogue and trust in gaining bank loyalty: an extended SWICS model
Authors: Hoang Dung Phuong 
Published: April 2019

Purpose
The purpose of this paper is to expand the Swiss Index of Customer Satisfaction (SWICS) model by investigating the role of customer dialogue in the interrelationships among customer satisfaction, customer trust, perceived value and customer loyalty upon Vietnam banking industry.

Design/methodology/approach
The conceptual framework was developed from both an exploratory research with focus group method and the literature. A structural equation model linking customer dialogue to customer satisfaction, customer trust, perceived value and loyalty is tested using data from a sample of 389 Vietnamese individual bank customers.

Findings
The results indicate the key role of customer dialogue in bank marketing since it not only has an independent impact on customer loyalty but also mediates the effect of customer satisfaction on loyalty completely and the relationship between customer trust and loyalty partially. Besides, the central role of customer trust was also highlighted since it mediates totally the effect of perceived value on both of customer dialogue and customer loyalty while explaining partially the path from customer satisfaction and customer dialogue.

Research limitations/implications
First, regarding sample size, the authors have used suitable sampling methods with adequate sample representation. However, a larger sample size with more diverse age range and usage of various banking services may be more helpful and effective for the path analysis and managerial implication. Second, the authors have used only a limited set of measurement items due to the concerns of model parsimony and data collection efficiency. For example, perceived value can be measured upon more detailed dimensions, and yet the author focussed only on some selected measures based mainly on their relevance to the context studied.

Practical implications
The findings imply that building trust and engaging with customers better through communication are keys for Vietnamese commercial banks to gain more customer loyalty in such competitive conditions.

Originality/value
The study is noteworthy that it adds perceived value and customer trust in the SWICS model and investigates the interrelationships between all variables in a single model.
Liquidity creation and bank performance: evidence from MENA
Authors: Sahyouni Ahmad , Wang Man 
Published: April 2019

Purpose
Islamic banks have significantly different balance sheets from their conventional counterparts, leading to different implications in relation to liquidity creation compared to conventional banks. This work, first, investigates the liquidity creation of conventional and Islamic banks in Middle Eastern and North African (MENA) countries between 2011 and 2016. It then tests the relationship between liquidity creation and performance of these banks.

Design/methodology/approach
It uses the data of 491 commercial banks across 18 MENA countries between 2011 and 2016. The analysis is based on panel data techniques.

Findings
The banks created US$18.596 trillion of liquidity, about 28.4% of total assets. Conventional banks created more liquidity compared with Islamic banks. Nevertheless, Islamic banks created more liquidity per asset compared with conventional banks. The regression analysis revealed a significant and negative correlation between liquidity creation and performance of the banks using return on average equity (ROAE) measure. However, no significant relationship is observed between liquidity creation and return on average assets (ROAA) of MENA banks. Moreover, there is no difference between Islamic and conventional banks in the relation between liquidity creation and bank performance.

Research limitations/implications
The data are limited to the period 2011-2016; the period of this study was selected based on yearly data availability from the data source. Accounting measures were used to study the effect of liquidity creation on bank profitability, and the market-based measures were excluded, as there is no uniform sources in these countries that can be used to collect market-based data.

Practical implications
Bank managers must reach a trade-off between the advantages and disadvantages of liquidity creation, as well as consider the negative relationship between liquidity creation and bank performance when making their decisions.

Originality/value
First, to the best of the authors’ knowledge, this work is the first to analyse the relationship between the liquidity creation and performance of conventional and Islamic banks in MENA. Second, this study uses a sample of Islamic and conventional banks in MENA that have detailed information on the Orbis Bank Focus dataset, which is the most comprehensive database of commercial banks in the MENA region.
Hegemonic masculinity or masculine domination
Authors: Reddy Raghunandan , Sharma Arun Kumar , Jha Munmun 
Published: April 2019

Purpose
The purpose of this paper is to demonstrate that Bourdieu’s concept of masculine domination offers a comprehensive social theory of gender as compared to Connell’s concept of hegemonic masculinity through examining the proposition of positive hegemonic masculinity.

Design/methodology/approach
This is a conceptual paper that argues that Bourdieu’s concept of masculine domination offers a comprehensive social theory of gender as compared to Connell’s concept of hegemonic masculinity.

Findings
The findings demonstrate that Bourdieu’s concept of masculine domination incorporates both discursive and material structures of the gender system that privileges men/masculine over women/feminine, making it a comprehensive social theory of gender.

Research limitations/implications
The concepts of hegemonic masculinity and masculine domination have not been reviewed in the light of emerging perspectives on hegemony, power and domination. The future research could focus on a review of research methods such as institutional ethnography, in examining masculine domination.

Practical implications
Using masculine domination perspective, organizations could identify specific managerial discourses, aspects of work organization and practices in order to eliminate gender-based discrimination, harassment and unequal access to resources.

Social implications
Public policy interventions aimed at inclusive development could examine women’s condition of continued disadvantageousness, through masculine domination perspective.

Originality/value
The authors seek to provide a comparative view of the concepts of hegemonic masculinity and masculine domination, using the categories of comparison that was not attempted earlier.