bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microimaging spectroscopy and scanning electron microscopy of Northwest Africa 8657 shergottite: Interpretation of future in situ Martian data
Authors: Manzari P. , De Angelis S. , De Sanctis M. C. , Agrosì G. , Tempesta G. 
Published: December 2018

AbstractMicroimaging spectroscopy is going to be the new frontier for validating reflectance remote sensed data from missions to solar system bodies. In this field, microimaging spectroscopy of Martian meteorites can provide important and new contributions to interpret data that will be collected by next instruments onboard rover missions to Mars, such as for example Exomars‐2020/Ma_MISS spectrometer. In this paper, a slab from the Northwest Africa (NWA) 8657 shergottite was studied using the SPectral IMager (SPIM) microimaging spectrometer, in the visible‐infrared (VIS‐IR) range, with the aim to subsequently validate the spectral data by means of different independent techniques. The validation was thus carried out, for the first time, comparing SPIM spectral images, characterized by high spatial and spectral resolution, with mineralogical–petrological analyses, obtained by scanning electron microscopy (SEM). The suitability of the SPIM resolution to detect and map augite, pigeonite, maskelynite, and other minor phases as calcite, Ca‐phosphates, and troilite/pyrrhotite with no loss of information about mineral distribution on the slab surface, was ascertained. The good agreement found between spectral and mineralogical data suggests that spectral‐petrography of meteorites may be useful to support in situ investigations on Martian rocks carried out by MaMiss spectrometer during Exomars2020 mission. Moreover, micro spectral images could be also useful to characterize, in a nondestructive way, Martian meteorites and other rare minerals occurring in meteorites. The results obtained in this work represent not only a methodological contribution to the study of meteorites but furnish also elements to reconstruct the history of this sample. The finding of zoned pyroxene, symplectitic texture, amorphous phases as maskelynite, and Fe‐merrillite permits us to hypothesize four stages, i.e., (1) igneous formation of rimmed pyroxenes and other minerals, (2) retrograde metamorphism, (3) shock by impact, and (4) secondary minerals by terrestrial contamination.
Remote monitoring of implantable cardioverter defibrillators: Patient experiences and preferences for follow‐up
Authors: Timmermans Ivy , Meine Mathias , Szendey Istvan , Aring Johannes , Romero Roldán Javier , van Erven Lieselotte , Kahlert Philipp , Zitron Edgar , Mabo Philippe , Denollet Johan , Versteeg Henneke 
Published: December 2018

AbstractBackgroundPatient satisfaction with remote patient monitoring (RPM) of implantable cardioverter defibrillators (ICDs) seems to be high, yet knowledge on long‐term patient experiences is limited. The European REMOTE‐CIED study explored patients' experiences with RPM, examined patient's preferences for ICD follow‐up, and identified determinants of patient's preferences in the first 2 years postimplantation.MethodsEuropean heart failure patients (N = 300; median age = 66 years [interquartile range (IQR) = 59‐73], and 22% female) with a first‐time ICD received a Boston Scientific LATITUDE RPM system (Marlborough, MA, USA) and had scheduled in‐clinic follow‐ups once a year. Patients completed questionnaires at 1‐2 weeks and also at 3, 6, 12, and 24 months postimplantation and clinical data were obtained from their medical records. Patient evaluation data were analyzed descriptively, and Student's t‐tests/Man‐Whitney U tests or Chi‐square tests/Fisher's exact tests were performed to examine determinants of patient preferences.ResultsAt 2 years postimplantation, the median patient satisfaction score with the RPM system was 9 out of 10 (IQR = 8‐10), despite 53% of the patients experiencing issues (eg, failure to transmit data). Of the 221 patients who reported their follow‐up preferences, 43% preferred RPM and 19% preferred in‐clinic follow‐up. Patients with a preference for RPM were more likely to be higher educated (P = 0.04), employed (P = 0.04), and equipped with a new LATITUDE model (P = 0.04), but less likely to suffer from chronic obstructive pulmonary disease (P = 0.009).ConclusionIn general, patients were highly satisfied with RPM, but a subgroup preferred in‐clinic follow‐up. Therefore, physicians should include patients’ concerns and preferences in the decision‐making process, to tailor device follow‐up to individual patients’ needs and preferences.
Kant, the Third Antinomy and Transcendental Arguments
Authors: Gava Gabriele 
Published: December 2018

AbstractIn this paper, I consider whether a reading of Kant's solution to the Third Antinomy can offer material for devising a new model of transcendental argument. The problem that this form of argument is meant to address is an antinomy between two apparently contradictory claims,qand ¬q, where we seem equally justified in holding both. The model has the following form:p;qis a necessary condition ofp; the only justification we have forqis that it is a necessary condition ofp;pis justified only in domainX(whereXis a domain of objects of cognition); therefore,qis justified only in domainX. Because the argument shows that our justification forqis valid only inX, it also establishes that there is conceptual space to hold ¬qoutside ofX.
An on‐site health home for homeless men in addiction recovery
Authors: Lashley Mary 
Published: December 2018

AbstractPatients with comorbid substance abuse, mental health disorders, and chronic health conditions face difficult challenges when attempting to access health care. A large gospel rescue mission developed an onsite wellness center, based on an integrated, embedded practice health home model, to promote health care access among homeless men in addiction recovery. The center model integrated primary care with behavioral health, specialty care referrals, and wellness services to address the multifaceted needs of the population. Standardized health care performance measures and resident and staff feedback support the effectiveness of the model in promoting improved health care access and treatment adherence. Future directions for program expansion include infrastructure development, expanded community outreach, and evaluation of effectiveness of the onsite health home through systematic program evaluation and research.
Look at my pearly white teeth: Exploring adolescents' oral health behavior
Authors: Calderon Susana J. , Mallory Caroline 
Published: December 2018

AbstractInformed by grounded theory, this study explored adolescent oral health behaviors to determine what factors influence them and to develop a substantive theory explaining the social process behind the behaviors identified. Multiple types of data were collected and analyzed simultaneously: demographic and oral health questionnaires, 16 individual interviews, eight small group discussions, field notes, and investigator memoing. Participants were 37 Midwestern adolescents aged 13–18, and most were White or African‐American females 14 years of age whose parents had at least a high school education. While more than half reported using mouthwash and brushing their teeth regularly, almost all participants described their behavior in terms of relationships, confidence, and attractiveness rather than health. Top motivators were habits learned as children and the desire to be attractive or “kissable.” To reflect teens' understanding of “healthy” as good‐looking, and their primary concern not with having healthy teeth but with being attractive to peers, our model of the basic social process of adolescent oral health behavior is called “Look at my Pearly White Teeth.” Understanding the actual motivations behind adolescent oral health behavior can help public health administrators develop more effective interventions, especially for teens who did not learn healthy habits as children.
Risk of skin cancer in psoriasis patients receiving long‐term narrowband ultraviolet phototherapy: Results from a Taiwanese population‐based cohort study
Authors: Lin Teng‐Li , Wu Chun‐Ying , Chang Yun‐Ting , Juan Chao‐Keui , Chen Chi‐Chiang , Yu Shi‐Hang , Chen Yi‐Ju 
Published: December 2018

SummaryBackgroundNarrowband ultraviolet B (NB‐UVB) phototherapy is a widely used treatment for various dermatoses. The risk of skin cancer following long‐term NB‐UVB phototherapy has rarely been explored in skin phototypes III‐V.MethodsWe conducted a nationwide‐matched cohort study and identified a total of 22 891 psoriasis patients starting NB‐UVB phototherapy from the Taiwan National Health Insurance Database during the period 2000‐2013. Cumulative incidences of skin cancers were compared between subjects receiving less than 90 UVB treatments (S‐cohort, N = 13 260) and age‐ as well as propensity score‐matched subjects receiving more than or equal to 90 UVB treatments (L‐cohort, N = 3315).ResultsThere were no significant differences in the overall cumulative incidences of skin cancers between the two cohorts (log‐rank t test, P = 0.691) during the follow‐up periods. The S‐cohort had a significantly lower prevalence of actinic keratosis when compared with the L‐cohort (0.54% vs 1.00%, P = 0.005).ConclusionLong‐term NB‐UVB phototherapy does not increase skin cancer risk compared with short‐term NB‐UVB phototherapy in psoriasis patients with skin phototypes III‐V.
Management and treatment of the HCV‐infected kidney transplant patient
Authors: Wong Tiffany , Bloom Roy D. 
Published: December 2018

AbstractThe prevalence of hepatitis C virus infection is increased in patients with end stage kidney disease compared to the general population and is an adverse outcome determinant. Direct‐acting antiviral therapy for hepatitis C virus is changing the management paradigm of infected kidney transplant candidates and recipients, with potential to reduce patient morbidity and mortality. This review describes the hepatic and nonhepatic manifestations of hepatitis C virus in kidney transplant patients as well as management and treatment strategies to optimize transplant outcomes, highlighting the importance of direct‐acting antivirals in this population.
Effects of Issue‐Specific Political Advertisements in the 2015 Parliamentary Elections of Switzerland
Authors: Zumofen Guillaume , Gerber Marlène 
Published: December 2018

AbstractOur paper captures the influence of political advertisements on vote intentions in the framework of the 2015 parliamentary elections. We focus on the two winning parties, the FDP and SVP, and the promotion of their stances on immigration/asylum, relations to the EU and the economy. We make use of an extensive database on political advertisements collected in 50 important national and regional newspapers that we link to the Selects respondents. Our findings only hint at limited effects of issue‐specific advertisements with regard to the activation of latent preferences, suggesting that campaigns mattered more when they have managed to make a party's issue positions known to the electorate. The general reinforcement tendencies detected for migration ads of the SVP suggest that reinforcement effects might be particularly prone when highly contentious issues are at stake. Our results indicate that the SVP did not manage to mobilize new voters with their political advertisements.
Interest Group Support and Electoral Success in the Swiss Elections of 2015. A Candidate Survey Analysis
Authors: Lutz Georg , Mach André , Primavesi Riccardo 
Published: December 2018

AbstractPoliticians, parties and interest groups are strongly interlinked in Switzerland. Most studies focus on the interest group influence during parliamentary legislative processes. This article fills a gap by focusing on a question that was largely ignored so far: the impact of interest group support on electoral success of candidates. We collected information on the magnitude and nature of self‐reported relations between individual candidates and many interest groups in the 2015 Swiss national election. This new and unique data set allows us to explore the varying impact of specific interest group types on candidates electoral success. Being endorsed by many interest group and occupying leading positions are positively correlated with larger shares of preference votes, while financial contribution show no significant impact. There is, however, variation how endorsements by and leading positions at interest group matter for candidates from different parties depending on the type of interest group.
Toxoplasma gondiiseroprevalence in veterinarians in Finland: Older age, living in the countryside, tasting beef during cooking and not doing small animal practice associated with seropositivity
Authors: Siponen Anne‐Marika , Kinnunen Paula M. , Koort Joanna , Kallio‐Kokko Hannimari , Vapalahti Olli , Virtala Anna‐Maija , Jokelainen Pikka 
Published: December 2018

AbstractPractising veterinary medicine has an inherent risk of exposure to zoonotic agents, including the protozoan parasiteToxoplasma gondii. We screened sera of veterinarians authorized to work in Finland for the presence of specific immunoglobulin G antibodies againstT. gondiiwith an enzyme‐linked fluorescent assay, and evaluated potential risk factors forT. gondiiseropositivity from extensive questionnaire data with almost 1,300 quantitative variables. We used a causal diagram approach to address the complexity of the life cycle of the parasite and its numerous possible transmission routes, and built a multivariable binomial logistic regression model to identify risk factors that are particularly relevant for veterinarians. The samples and questionnaire data were collected in 2009. Altogether, 294 veterinarians, almost 15% of the Finnish veterinary profession, were included in the study. The median age was 39 years, and the majority, 86%, were women. Altogether, 43 (14.6%; 95% confidence interval: 10.9–19.0) of the 294 veterinarians tested seropositive forT. gondii. According to the final model, veterinarians who were at least 40 years old had 2.4 times higher odds to be seropositive than younger veterinarians; veterinarians who lived in the countryside had 4.0 times higher odds to be seropositive than veterinarians who lived in towns; female veterinarians who tasted beef during cooking had 2.6 times higher odds to be seropositive than male veterinarians who did not taste beef during cooking; and veterinarians who did not do small animal practice had 2.3 times higher odds to be seropositive than those who did. The results illustrate the numerous transmission routes ofT. gondii.
Relação entre folga financeira e desempenho econômico em empresas cinquentenárias e não cinquentenárias
Authors: Da Silva Tarcísio Pedro , Rohenkohl Leonardo Bernardi , Bizatto Luana Sara 
Published: December 2018

não cinquentenárias. O intuito é fomentar pesquisas que levem em consideração as diferenças entre empresas com distinto tempo de permanência no mercado, devido a que existe escassez de pesquisas que considerem a idade da empresa. Para a realização do estudo, foram consultadas empresas listadas nos indicadores Índice Brasil 100 (IBrx-100) e Índice de Governança Corporativa – Novo Mercado (IGC-NM), da Bolsa de Valores, Mercadorias e Futuros de São Paulo, com uma amostra de 78 empresas nãocinquentenárias e 34 empresas cinquentenárias. Por meio da estatística descritiva e da correlação canônica, concluiu-se que tanto em empresas cinquentenárias como em não cinquentenárias a folga financeira tem relação com o desempenho econômico. Assim, as empresas cinquentenárias possuem grau de relação mais forte entre os dois conjuntos de indicadores que as não cinquentenárias. Desta forma, é possível que as empresas devam considerar seu tempo de mercado, ou seja, o grau de estabilidade e maturidade quepossuem, para compreenderem o menor ou maior uso da folga financeira com intuito de elevarem seus desempenhos econômicos, uma vez que uma maior relação entre a folga financeira e o desempenho econômico é perceptível em empresas com mais de 50 anos.
Riesgos estratégicos. Un estudio de las medidas de tratamiento implementadas por las grandes empresas privadas de Antioquia, Colombia
Authors: Jaraba Isabel , Nuñez María Antonia , Villanueva Eduart 
Published: December 2018

Los cambios que enfrentan las organizaciones pueden poner en riesgo su normal desarrollo y afectar el cumplimiento de objetivos y metas. Por eso, es de vital importancia que estas puedan administrar esos riesgos adecuadamente mediante un proceso de identificación, evaluación y tratamiento. El objetivo de esta investigación fue analizar cómo las medidas de tratamiento utilizadas por las grandes empresas privadas de Antioquia permiten desarrollar conocimiento que faculta a los directivos para tomar decisiones que aporten al crecimiento de las organizaciones. Para cumplir con este propósito se realizó un estudio de carácter cualitativo, en el cual se examinaron diferentes fuentes de información documental relacionadas con el tema, con el fin de obtener instrumentos y herramientas que permitieran la apropiación de conocimiento. Igualmente, se aplicaron entrevistas semiestructuradas a altos directivos de empresas que cuentan con una estructura de administración de riesgos estratégicos. Los resultados de esta investigación aportan conocimiento sobre las medidas de tratamiento de riesgos estratégicos.
Valuing the impact of health and social care programmes using social return on investment analysis: how have academics advanced the methodology? A protocol for a systematic review of peer-reviewed literature
Authors: Hutchinson Claire Louise , Berndt Angela , Gilbert-Hunt Susan , George Stacey , Ratcliffe Julie 
Published: December 2018

IntroductionUnlike other forms of evaluation, social return on investment (SROI) methodology offers a way of placing values on personal, social and community outcomes, not just economic outcomes. Developed in 2000, there have been calls for greater academic involvement in development of SROI, which to date has been more typically implemented in-house or by consultants. This protocol describes a systematic review of SROI analysis conducted on health and social care programmes which represent a significant sector of social enterprise internationally. The aims of the systematic review are to (1) identify the extent to which academics have adopted SROI methodology, (2) how academics have interpreted, used and developed SROI methodology and (3) to assess the quality of studies published under peer review.Methods and analysisThe systematic review will include peer-reviewed studies since 2000 published in English. Search terms will be ‘social return on investment’ or ‘SROI’. Health and social care interventions will be identified in the initial screening given the proliferation of possible key words in these areas. Databases to be searched include Web of Science, Scopus, Medline, Social Care Online and National Institute for Health and Care Excellence. Two reviewers will independently conduct initial screening based on titles and abstracts against the inclusion criteria. Data extracted will include date of intervention, country, study design, aim of intervention/programme, participants and setting, health and social care measures used, and SROI ratio. The quality of studies will be assessed by two reviewers using a SROI quality framework designed for the purpose of this study.Ethics and disseminationThe systematic review will review existing published academic literature; as such, ethics approval is not required for this study. A paper of the systematic review will be submitted to a peer-reviewed journal.PROSPERO registration numberCRD42018080195.
Breast cancer risk in neurofibromatosis type 1 is a function of the type of NF1 gene mutation: a new genotype-phenotype correlation
Authors: Frayling Ian M , Mautner Victor-Felix , van Minkelen Rick , Kallionpaa Roope A , Aktaş Safiye , Baralle Diana , Ben-Shachar Shay , Callaway Alison , Cox Harriet , Eccles Diana M , Ferkal Salah , LaDuca Holly , Lázaro Conxi , Rogers Mark T , Stuenkel Aaron J , Summerour Pia , Varan Ali , Yap Yoon Sim , Zehou Ouidad , Peltonen Juha , Evans D Gareth , Wolkenstein Pierre , Upadhyaya Meena 
Published: December 2018

BackgroundNeurofibromatosis type 1 (NF1) predisposes to breast cancer (BC), but no genotype-phenotype correlations have been described.MethodsConstitutional NF1 mutations in 78 patients with NF1 with BC (NF1-BC) were compared with the NF1 Leiden Open Variation Database (n=3432).ResultsNo cases were observed with whole or partial gene deletions (HR 0.10; 95% CI 0.006 to 1.63; p=0.014, Fisher’s exact test). There were no gross relationships with mutation position. Forty-five (64.3%; HR 6.4–83) of the 70 different mutations were more frequent than expected (p<0.05), while 52 (74.3%; HR 5.3–83) were significant when adjusted for multiple comparisons (adjusted p≤0.125; Benjamini-Hochberg). Higher proportions of both nonsense and missense mutations were also observed (adjusted p=0.254; Benjamini-Hochberg). Ten of the 11 missense cases with known age of BC occurred at <50 years (p=0.041). Eighteen cases had BRCA1/2 testing, revealing one BRCA2 mutation.DiscussionThese data strongly support the hypothesis that certain constitutional mutation types, and indeed certain specific variants in NF1 confer different risks of BC. The lack of large deletions and excess of nonsenses and missenses is consistent with gain of function mutations conferring risk of BC, and also that neurofibromin may function as a dimer. The observation that somatic NF1 amplification can occur independently of ERBB2 amplification in sporadic BC supports this concept. A prospective clinical-molecular study of NF1-BC needs to be established to confirm and build on these findings, but regardless of NF1 mutation status patients with NF1-BC warrant testing of other BC-predisposing genes.
Hospitalisation and life support in the year before and during heart transplantation: a French national study
Authors: Cantrelle Christelle , Dorent Richard , Legeai Camille , Damy Thibaud , Bastien Olivier , Tuppin Philippe 
Published: December 2018

ObjectiveThe objective of this study was to define the characteristics of hospital care use during the year prior to heart transplantation.MethodsA retrospective cohort of heart transplant recipients registered on the national hospital discharge database between 2010 and 2015 was analysed.ResultsIn this cohort of 2379 heart transplant recipients (mean age: 48 years, 74% men), 91% had been admitted at least once, for at least 1 day, to a short-stay hospital during the year before transplantation (mean: 4.3 days), and 84% had at least one cardiovascular diagnosis (heart failure and cardiogenic shock: 60%). At least one intensive care stay was reported for 61% of patients, a rehabilitation stay was reported for 30%, mechanical circulatory support was reported for 12%, and ventilatory support was reported for 15%. The median interval between admission and transplantation was 5 days (interquartile QI–Q3, 0–16). The hospital mortality was higher for patients not hospitalised before transplantation (18% vs 15%). Their transplantation hospitalisation diagnosis, compared with patients hospitalised before transplantation, was more frequently cardiomyopathy (31% vs 27%) or heart failure (28% vs 18%), and less frequently myocardial infarction (1% vs 12%).ConclusionThis study demonstrates a high hospitalisation rate before heart transplantation and identifies three groups of patients: 1—patients with a high hospitalisation rate and terminal heart failure requiring circulatory support who experienced at least one intensive care unit stay; 2—patients with a history of hospitalisation, mainly for heart disease, without circulatory support requirement; and 3—patients with no pretransplantation overnight stay. These findings provide useful information to evaluate the medical benefits and needs for transplantation, and identify areas for improvement in heart transplantation listing criteria.