bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaccine equity implementation: exploring factors influencing COVID-19 vaccine delivery in the Philippines from an equity lens
Authors: Zhao Junqiang , Wu Shishi , Rafal Renz Andrew , Manguerra Helena , Dong Quanfang , Huang Hongyu , Lau Lincoln , Wei Xiaolin 
Published: November 2024

Abstract
Background
During the early phase of the COVID-19 vaccine rollout, low and middle-income countries (LMICs) were facing challenges in achieving equitable vaccine delivery. Few studies have contextualized global vaccine distributive injustice into national-specific contexts to understand its impact on vaccine delivery from an equity perspective. We aimed to investigate factors influencing equitable COVID-19 vaccine delivery in the Philippines and to provide recommendations to enhance equitable vaccine delivery in LMICs to prepare for future health emergencies.

Methods
The Health Equity Implementation Framework was employed to guide this qualitative study. We recruited participants using purposeful and snowballing sampling strategies. Semi-structured interviews were conducted with participants in person, online, or over the phone. A reflective thematic analysis approach was employed to analyze data.

Results
We recruited 38 participants including seven high-level stakeholders from the public and private sectors, 14 health workers, and 17 community members in the province of Negros Occidental, Philippines. Equitable delivery of COVID-19 vaccines was influenced by an interplay of multiple factors operating in different domains. Contextually, the rapidly evolving nature of the COVID-19 virus, ongoing scientific advancements, and international negotiations directed national-level vaccine policies. Political commitment and support were recognized as crucial drivers for successful vaccine delivery, with a strong emphasis on health information framing and communication and adherence to human rights principles. The vulnerability of the health system significantly impacted the timely and effective distribution of vaccines. Furthermore, the geographical characteristics of the Philippines presented unique logistical challenges to vaccine delivery. At the recipient domain, individual perceptions of vaccines, shaped by their socioeconomic status, exposure to (mis)information, social influence, and entrenched religious beliefs, played a major role in their vaccine decisions and thus vaccine coverage regionally. Additionally, vaccine characteristics and operational challenges related to its distribution also impacted fair allocation.

Conclusions
The findings highlight the urgent need for LMICs to strengthen their health system resilience and sustainability and use multilevel strategies to build public trust to improve vaccine uptake and coverage. Moreover, each LMIC must be attentive to its unique contextual factors to develop tailored implementation strategies to promote equitable vaccine distribution.
Healthy longevity-associated protein improves cardiac function in murine models of cardiomyopathy with preserved ejection fraction
Authors: Alvino Valeria Vincenza , Slater Sadie , Qiu Yan , Cattaneo Monica , Mohammed Khaled Abdelsattar Kassem , Gate Seamus , Sekar Vealmurugan , Puca Annibale Alessandro , Madeddu Paolo 
Published: November 2024

Abstract
Aims
Aging is influenced by genetic determinants and comorbidities, among which diabetes increases the risk for heart failure with preserved ejection fraction. There is no therapy to prevent heart dysfunction in aging and diabetic individuals. In previous studies, a single administration of the longevity-associated variant (LAV) of the human BPIFB4 gene halted heart decline in older and type 2 diabetic mice. Here, we asked whether orally administered LAV-BPIFB4 protein replicates these benefits.

Materials and Methods
In two controlled, randomized studies, 18-month-old male C57BL/6 J mice and 9-week-old C57BLKS/J-Leprdb/Leprdb/Dock7 + [db/db] mice of both sexes underwent baseline echocardiography. They then received a recombinant purified LAV-BPIFB4 protein (3 µg/animal, every three days) or vehicle by gavage. After 30 days, the animals underwent echocardiography, and the hearts were collected post-termination for histology.

Results
All the animals completed the study except one female diabetic mouse, which was culled prematurely because tooth malocclusion caused eating problems. There was no effect of the LAV-BPIFB4 protein on body weight in the two studies or glycosuria in the diabetic study. In aging mice, LAV-BPIFB4 increased myocardial Bpifb4 expression, improving heart contractility and capillarity while reducing perivascular fibrosis and senesce. In male diabetic mice, LAV-BPIFB4 therapy improved systolic function, microvascular density, and senescence, whereas the benefit was limited to systolic function in females.

Conclusions
This study shows the feasibility and efficacy of a variant protein associated with human longevity in contrasting pivotal risk factors for heart failure in animal models. The diabetic study revealed that sex influences the treatment efficacy.
A “silent storm”: uncovering the escalating crisis in mental healthcare for children and adolescents in Slovenia during and after the COVID-19 pandemic
Authors: Mali Sanja Zupanič , Karakatič Sašo , Radobuljac Maja Drobnič 
Published: November 2024

Abstract
Aim
Our aim was to assess the burden of children and adolescents’ mental health problems on the Slovenian outpatient healthcare system before, during and after the pandemic.

Methods
In a retrospective analysis of healthcare indicators from 2008 to 2023, we analysed data from the National Institute of Public Health. Key domains included initial visits for mental and behavioural disorders (MBDs) to primary care for the population aged 0–19; the number of referrals to an initial assessment with a child and adolescent psychiatrist (CAP) at the secondary level for the population aged 0–17 along with the corresponding waiting times; and the number of urgent referrals for the population aged 0–17 to emergency mental health centres at the tertiary level. The calculations included rates per 1000 people. Descriptive statistics and diagrams were used to compare the data. Segmented linear regression analysis (SLR) was conducted on the primary healthcare data to identify the distinct temporal point indicating an increase.

Results
Comparing the average rates of the 2020–2022 period to those of the 2018–2019 period, there was a 20% increase in initial visits to primary care, a 23% increase in the referral rate to a CAP at the secondary level, and a 41% increase to the tertiary level of care. In secondary care, a four- to sevenfold increase in waiting times for the initial CAP assessment was observed between 2019 and 2023. The incidence of initial visits to primary healthcare services for MBD increased from 2008 to 2019 (average annual growth rate of 4.5%). The average annual growth rate for the 2020–2022 period tripled to 13.9%. The SLR showed that the trend of accelerating growth could have begun in 2017 for the 0–5 age group and possibly for the 15–19 age group as well.

Conclusions
After the initial decline in 2020, all levels of the Slovenian healthcare system faced an increased burden of MBD in children and adolescents from 2021 to 2022 compared to pre-pandemic levels. Nevertheless, a portion of this increase aligns with longitudinal growing trends from 2008 onwards. Tackling the crisis requires urgent national action, significant improvement in organization, and investments in mental health.
The first report of rhinosinusitis by Rhizopus delemar in a patient with severe COVID-19 in Iran: a case report
Authors: Mojtahedi Seyedeh Sabereh , Hosseinikargar Neginsadat , Zarrinfar Hossein , Bakhshaee Mehdi , Najafzadeh Mohammad Javad , Zhou Ya Bin , Houbraken Jos 
Published: November 2024

Abstract
Background
Mucormycosis is a severe and fatal fungal infection in patients with coronavirus disease 2019 caused by Mucorales. Here we present a case of a 63-year-old man with coronavirus disease 2019 infection, along with rhinosinusitis mucormycosis caused by Rhizopus delemar.

Case presentation
A 63-year-old Iranian man suffering from a coronavirus disease 2019 infection with symptoms of cough, shortness of breath, and generalized body pain. On the basis of the clinical manifestations, such as headache, a history of black nasal discharge, nasal hypoesthesia, facial swelling, numbness, nasal obstruction, presence of necrotic lesions on the nasal passages on physical examination, and abnormal computed tomography scans of paranasal sinuses, the patient underwent surgical debridement. Direct microscopy of specimens obtained from the paranasal sinuses, and subsequent isolation and identification, revealed a rhinosinusitis mucormycosis caused by R. delemar. Despite therapeutic measures, such as sinus debridement surgery and antifungal therapy with amphotericin B injection (50 mg/day), the patient died after 35 days of hospitalization.

Conclusion
In this report, we present the first documented case of human infection with R. delemar in a patient with coronavirus disease 2019 infection, who also exhibited rhinosinusitis mucormycosis. R. delemar appears to be an emerging agent of rhinosinusitis mucormycosis in this region. Furthermore, prompt diagnosis and the exploration of alternative antifungal treatments, beyond amphotericin B, may be crucial for effectively managing patients with R. delemar infections.
Long-term outcomes of spinal fusion in adolescent idiopathic scoliosis: a literature review
Authors: Pishnamaz Miguel , Migliorini Filippo , Blume Christian , Kobbe Philipp , Trobisch Per , Delbrück Heide , Hildebrand Frank , Herren Christian 
Published: November 2024

AbstractAdolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity in the younger population. The surgical management for these patients improved constantly over the last year and might not be comparable to modern treatment strategies. However, under this aspect the present investigation updates and discusses current evidence regarding the long-term outcome of the surgical management of AIS. All the clinical studies which evaluated the long-term outcomes of spinal fusion were considered. Level of evidence, clinical and radiological data, results of health-related questionnaires and surgery-associated complications during long-term follow-up, e.g., proximal and distal junctional kyphosis (PJK/DJK), and adjacent segment degeneration (ASD), are presented. Data concerning the following patient-reported outcomes measures were collected: Oswestry Disability Index (ODI), Scoliosis Research Society (SRS) Outcome Questionnaire, visual analogue scale (VAS), and short form-12 and 36 (SF-12/SF-36). Overall, data from 1115 patients were included. Of them, 324 underwent anterior and 791 posterior spinal fusion. One study focuses on a combined anterior/posterior fusions. The mean follow-up was 22.6 years (posterior fusion: 24.6 years, anterior fusion: 18.31 years). Seven studies focus on the thoracic segments, while 12 focus on the lumbar spine. Data on imaging was reported in 13 studies and those on PROMs in 15 investigations. In conclusion, there is low quality and paucity of long-term data on AIS. However, the long-term results of the implicated studies on AIS patients in this review appear to be satisfactory, although there are limitations in the outcome compared to healthy comparison cohorts. Adjacent degenerations appear to be the most common mechanical complication after long-segment fusions, despite their influence on the outcome remains unclear. With regard to pregnancies, there are slightly increased cesarean section rates, which could be explained by deviations in the sagittal profile.
Pharmacokinetic profile of novel multi-layer stable effervescent tablet: a cross-over study with an established European brand in healthy young male adults
Authors: Dani Danish Hassan , Shyum Naqvi Syed Baqir , Akram Muhammad , Ullah Matti , Khaliq Sheikh Abdul , Akhtar Muhammad Masoom , Abdullah Orva , Badshah Syed Faisal , Bourhia Mohammed , Shazly Gamal A. , Bin Jardan Yousef A. , Fazil Srosh 
Published: November 2024

AbstractEffervescent formulation helps in faster and better absorption of drugs, especially those that are rapidly soluble in water. However, these tablets require special packaging in order to prevent them from absorbing moisture, hence increasing cost. We compared an effervescent tablet prepared using an in-house developed method (multi-layer tablet with acid and base part separated by an inert layer) to a European effervescent tablet (Efferalgan®) in a single-center, randomized cross-over study among twelve healthy volunteers. Blood samples were collected for 8 h and analyzed for paracetamol concentration using HPLC. Our results showed that both the products have similar pharmacokinetic profiles with no significant difference observed for Clast, Thalf, Kelim, and MRT (p-value > 0.05). Moreover, to assess bioequivalence we did not find any significant difference (p-value > 0.05) in AUC (27.12 ± 6.02 vs. 27.29 ± 2.64 µg.h/ml), Cmax (7.42 ± 1.06 vs. 7.83 ± 1.19 µg/ml) and tmax (0.85 ± 0.22 vs. 0.83 ± 0.25 h). The TR ratios for AUC, Cmax, and tmax were 0.99, 0.95, and 1.02 respectively, and were all within the specified FDA limits i.e., 0.8–1.25. We found our test tablet to be bioequivalent to that of Efferalgan®.
Graphical Abstract
A study of peri-implant tissue clinical parameters in patients starting anti-osteoporosis medication after existing implant function: a prospective cohort study
Authors: Seki Keisuke , Tamagawa Takaaki , Yasuda Hiroyasu , Manaka Soichiro , Akita Daisuke , Kamimoto Atsushi , Hagiwara Yoshiyuki 
Published: November 2024

AbstractPurposeRecently, rare cases of medication-related peri-implant osteonecrosis of the jaw (PI-MRONJ) have been reported. In patients with functional implants who begin using anti-osteoporosis medications (AOMs) after implantation, PI-MRONJ is unpredictable and poses a significant threat to the patient. In this study, we aimed to evaluate the impact of AOMs on peri-implant tissues and to examine risk factors for peri-implantitis, a presumed trigger for PI-MRONJ.MethodsThe study cohort consisted of patients who underwent implant maintenance treatment between January 2016 and February 2024. Patients were divided into AOM users (AOM group) and controls (control group). Clinical parameters were statistically evaluated, including implant probing depth (iPPD), implant bleeding on probing (iBoP), marginal bone resorption (MBL), and mandibular cortical index (MCI) measured at baseline and at the last visit. Risk factors were examined by multivariate analysis for adjusted odds ratios.ResultsA total of 94 patients (35 male, 59 female) with 270 implants were recruited. The AOM group had 93 implants (24 patients). Comparison of clinical parameters showed significantly greater changes in iBoP (p = 0.000768) and MBL (p = 0.000863) scores over time in the AOM group than in the control group. Risk factors for peri-implantitis were a history of moderate or severe periodontal disease (OR: 15.8, 95% CI 3.6–69.3,p = 0.000256) and MCI class 3 (OR: 3.3, 95% CI 1.4–7.8,p = 0.00534).ConclusionsIn implant treatment of AOM users, special attention should be paid to local inflammation, which is presumed to be the cause of PI-MRONJ.Graphical Abstract
A case of anterior mediastinal mature teratoma with severe inflammatory extension into the neck
Authors: Keiya Tomoki , Uehara Hirofumi , Aoyagi Miho , Watanabe Atsushi 
Published: November 2024

Abstract
Background
We present the case of a rare occurrence of an anterior mediastinal mature teratoma extending into the neck, commonly referred to as a cervicothoracic mature teratoma.

Case presentation
A 19-year-old female presented with right-sided neck pain and swelling, which were found to be attributed to a 14 cm cystic lesion originating from the right thyroid lobe and extending into the mediastinum. A diagnosis of mediastinal teratoma with extension to the neck was made. Robot-assisted thymectomy was initiated but was complicated by dense tumor adherence to the superior vena cava and brachiocephalic veins, prompting a switch to a midline sternotomy. Simultaneous resection of the right thyroid lobe was performed due to inflammation. The transition to a midline sternotomy allowed successful excision of the tumor, which was confirmed to be a mature teratoma confined to the thoracic region. The patient's favorable postoperative course led to discharge on day 5 with no recurrence at nine months.

Conclusions
Emphasizing the challenges and the importance of prompt intervention in the management of mediastinal teratomas with neck extension.
Validation of the Chinese Maudsley three-item visual analogue scale to measure depressive symptoms in a youth population
Authors: Ding Yi , Strawbridge Rebecca , Young Allan H. , Xue Lingfeng , Zhao Fangfang 
Published: November 2024

Background
Existing self-rated depression measurement tools possess a range of psychometric drawbacks, spanning a range of validity and reliability constructs. The gold standard self-rated depression scales contain several variable items that are often non-specific, require respondents to have a certain level of language understanding and limited scoring options resulting in low sensitivity. The Maudsley three-item visual analogue scale (M3VAS) was developed to address these challenges.

Aims
This study aimed to translate the M3VAS into Chinese and test its reliability and validity.

Method
First, both M3VAS scales (assessing current severity and change in severity) were translated according to a standardised protocol to finalise the Chinese version. Reliability and validity were then examined among 550 young people with moderate to severe depression (patient health questionnaire-9 (PHQ-9) score ≥15) in a cross-sectional opportunistic questionnaire survey.

Results
The content validity of each item (six items, across both scales) ranged from 0.83 to 1.00. Exploratory factor analysis denoted a total of two common factors, with a variance contribution rate of 64.34%. The total score correlated positively with the PHQ-9 total score (r = 0.241, P < 0.01). The Chinese version of the M3VAS had good reliability and validity values, and the confirmatory factor model fit well.

Conclusions
The psychometric properties of the Chinese version of the M3VAS suggest that this scale can feasibly evaluate depression among young people in China.
Indirect Value of Public Infrastructure Technology
Authors: Liu Jialu , Pei Siqi , Zhang Xiaoquan (Michael) 
Published: November 2024

Although prior research has primarily focused on the direct value of information technology (IT) and IT adoption by individuals and firms, this study explores the indirect value of IT in the form of public infrastructure technology. By exploiting a spatial discontinuity in water monitoring stations, we discover that firms located immediately upstream of water monitoring stations exhibit significantly lower levels of corruption than firms located immediately downstream. These findings are particularly noteworthy given that water monitoring stations have the potential to generate significant indirect value as they are not explicitly designed to mitigate corruption. Further analyses reveal that public infrastructure technology alone does not hold the key to mitigating corporate corruption. Instead, it is the synergistic interplay between public infrastructure technology and organizational change that drives the outcome. These findings contribute to a deeper understanding of the broader IT value landscape, emphasizing the indirect value of technological advancements in public infrastructure that were not originally intended for such benefit. Additionally, our findings highlight the benefits of leveraging existing infrastructure technology to address emerging societal needs. This paper was accepted by D. J. Wu, information systems. Funding: J. Liu acknowledges financial support from the National Natural Science Foundation of China [Grant 72402127], Shanghai Pujiang Program [Grant 23PJC059] and the Chenguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission [Grant 23CGA10]. S. Pei acknowledges financial support from the National Natural Science Foundation of China [Grant 72302139]. X. (M.) Zhang acknowledges financial support from the Hong Kong Research Grants Council [Grants GRF 14500521, GRF 14501320, GRF 165052947, and TRS:T31-604/18-N]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.01145 .
Learning Dynamic Selection and Pricing of Out-of-Home Deliveries
Authors: Akkerman Fabian , Dieter Peter , Mes Martijn 
Published: November 2024

Home delivery failures, traffic congestion, and relatively large handling times have a negative impact on the profitability of last-mile logistics. A potential solution is the delivery to parcel lockers or parcel shops, denoted by out-of-home (OOH) delivery. In the academic literature, models for OOH delivery are so far limited to static settings, contrasting with the sequential nature of the problem. We model the sequential decision-making problem of which OOH location to offer against what incentive for each incoming customer, taking into account future customer arrivals and choices. We propose dynamic selection and pricing of OOH (DSPO), an algorithmic pipeline that uses a novel spatial-temporal state encoding as input to a convolutional neural network. We demonstrate the performance of our method by benchmarking it against two state-of-the-art approaches. Our extensive numerical study, guided by real-world data, reveals that DSPO can save 19.9 percentage points (%pt) in costs compared with a situation without OOH locations, 7%pt compared with a static selection and pricing policy, and 3.8%pt compared with a state-of-the-art demand management benchmark. We provide comprehensive insights into the complex interplay between OOH delivery dynamics and customer behavior influenced by pricing strategies. The implications of our findings suggest that practitioners adopt dynamic selection and pricing policies. History: This paper has been accepted for the Transportation Science special issue on TSL Conference 2023. Funding: This work was supported by TKI DINALOG.