bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is serial radiological evaluation of one-part proximal humeral fractures necessary?
Authors: Jacxsens Matthijs , Schmid Jeremias , Zdravkovic Vilijam , Jost Bernhard , Spross Christian 
Published: September 2019

Aims In order to determine whether and for whom serial radiological evaluation is necessary in one-part proximal humerus fractures, we set out to describe the clinical history and predictors of secondary displacement in patients sustaining these injuries. Patients and Methods Between January 2014 and April 2016, all patients with an isolated, nonoperatively treated one-part proximal humerus fracture were prospectively followed up. Clinical and radiological evaluation took place at less than two, six, 12, and 52 weeks. Fracture configuration, bone quality, and comminution were determined on the initial radiographs. Fracture healing, secondary displacement, and treatment changes were recorded during follow-up. Results In 100 patients (59 female, 41 male; mean age 57 years), 91 of the fractures (91%) remained stable. In five of nine patients (55%) with secondary displacement, surgery was recommended. Comminution, present in 23 patients (23%), was identified as a predictor of secondary displacement (p < 0.001). Patients’ age, sex, fracture configuration, and bone quality were not associated with secondary displacement (p ≥ 0.438). Nonoperative treatment resulted in a mean absolute Constant score (CS) of 80 (49 to 98), relative CS of 101% (63% to 138%), median subjective shoulder value of 95% (interquartile range (IQR) 90% to 100%), and median EuroQol five-dimensional questionnaire score of 0.89 (IQR 0.80 to 1.00) with bone union in all cases at one-year follow-up. Conclusion Radiological re-evaluation was only necessary in patients presenting with comminution and may be redundant for 77% of patients with one-part proximal humerus fractures. Nonoperative treatment of one-part proximal humerus fractures remains the mainstay of treatment with a low rate of secondary surgery, a high union rate, and good clinical results. Cite this article: Bone Joint J 2019;101-B:1307–1312
A randomized double-blind noninferiority trial, evaluating migration of a cemented vitamin E-stabilized highly crosslinked component compared with a standard polyethylene component in reverse hybrid total hip arthroplasty
Authors: Sköldenberg Olof G. , Rysinska Agata D. , Chammout Ghaz , Salemyr Mats , Mukka Sebastian S. , Bodén Henrik , Eisler Thomas 
Published: September 2019

AimsRadiostereometric analysis (RSA) studies of vitamin E-doped, highly crosslinked polyethylene (VEPE) liners show low head penetration rates in cementless acetabular components. There is, however, currently no data on cemented VEPE acetabular components in total hip arthroplasty (THA). The aim of this study was to evaluate the safety of a new cemented VEPE component, compared with a conventional polyethylene (PE) component regarding migration, head penetration, and clinical results.Patients and MethodsWe enrolled 42 patients (21 male, 21 female) with osteoarthritis and a mean age of 67 years (sd 5), in a double-blinded, noninferiority, randomized controlled trial. The subjects were randomized in a 1:1 ratio to receive a reverse hybrid THA with a cemented component of either argon-gas gamma-sterilized PE component (controls) or VEPE, with identical geometry. The primary endpoint was proximal implant migration of the component at two years postoperatively measured with RSA. Secondary endpoints included total migration of the component, penetration of the femoral head into the component, and patient-reported outcome measurements.ResultsIn total, 19 control implants and 18 implants in the VEPE group were analyzed for the primary endpoint. We found a continuous proximal migration of the component in the VEPE group that was significantly higher with a difference at two years of a mean 0.21 mm (95% confidence interval (CI) 0.05 to 0.37; p = 0.013). The total migration was also significantly higher in the VEPE group, but femoral head penetration was lower. We found no difference in clinical outcomes between the groups.ConclusionAt two years, this cemented VEPE component, although having a low head penetration and excellent clinical results, failed to meet noninferiority compared with the conventional implant by a proximal migration above the proposed safety threshold of RSA. The early proximal migration pattern of the VEPE component is a reason for continued monitoring, although a specific threshold for proximal migration and risk for later failure cannot be defined and needs further study. Cite this article: Bone Joint J 2019;101-B:1192–1198
What Matters in Population Health and How We Count It Among People With Intellectual and Developmental Disabilities
Authors: Havercamp Susan M. , Krahn Gloria L. 
Published: September 2019

Abstract
This issue, On Counting What Matters: Finding Adults With Intellectual and Developmental Disabilities in Population Health Data, presents an overview of health surveillance research for people with intellectual and developmental disabilities (IDD) in the United States. Although public health now conducts surveillance of people with disabilities broadly defined and compares their health status with that of individuals without disabilities, there are many challenges in conducting health surveillance of people with IDD. Difficulties include how to define cases, how to find cases, and how to obtain accurate information (Krahn, Fox, Campbell, Ramon, & Jesien, 2010). This issue will present critical conceptual and methodological issues, including recent prevalence and population health analyses, along with proposals that can lead to more equitable health and improved health surveillance for people with IDD.
Two-Hour Algorithm for Rapid Triage of Suspected Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay
Authors: Nestelberger Thomas , Boeddinghaus Jasper , Greenslade Jaimi , Parsonage William A , Than Martin , Wussler Desiree , Lopez-Ayala Pedro , Zimmermann Tobias , Meier Mario , Troester Valentina , Badertscher Patrick , Koechlin Luca , Wildi Karin , Anwar Mahnoor , Freese Michael , Keller Dagmar I , Reichlin Tobias , Twerenbold Raphael , Cullen Louise , Mueller Christian , Puelacher Christian , du Fay de Lavallaz Jeanne , Rubini Giménez Maria , Strebel Ivo , Walter Joan , Huber Jeffrey , Christ Michael , Kozhuharov Nikola , Gualandro Danielle M , Potlukova Eliska , Baumgartner Benjamin , Hafner Benjamin , Rentsch Katharina , Miró Òscar , Fuenzalida Carolina , Gil Beatriz , Martin-Sanchez F Javier , Kawecki Damian , Geigy Nicolas , Meissner Kathrin , Kulangara Caroline , López Beatriz , Rodriguez Adrada Esther , Ganovská Eva , Lohrmann Jens , Kloos Wanda , Steude Jana , Buser Andreas , von Eckardstein Arnold , Nowalany-Kozielska Ewa , Muzyk Piotr 
Published: September 2019

Abstract

BACKGROUND
We aimed to derive and externally validate a 0/2-h algorithm using the high-sensitivity cardiac troponin I (hs-cTnI)-Access assay.

METHODS
We enrolled patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction (AMI) in 2 prospective diagnostic studies using central adjudication. Two independent cardiologists adjudicated the final diagnosis, including all available medical information including cardiac imaging. hs-cTnI-Access concentrations were measured at presentation and after 2 h in a blinded fashion.

RESULTS
AMI was the adjudicated final diagnosis in 164 of 1131 (14.5%) patients in the derivation cohort. Rule-out by the hs-cTnI-Access 0/2-h algorithm was defined as 0-h hs-cTnI-Access concentration &lt;4 ng/L in patients with an onset of chest pain &gt;3 h (direct rule-out) or a 0-h hs-cTnI-Access concentration &lt;5 ng/L and an absolute change within 2 h &lt;5 ng/L in all other patients. Derived thresholds for rule-in were a 0-h hs-cTnI-Access concentration ≥50 ng/L (direct rule-in) or an absolute change within 2 h ≥20 ng/L. In the derivation cohort, these cutoffs ruled out 55% of patients with a negative predictive value (NPV) of 99.8% (95% CI, 99.3–100) and sensitivity of 99.4% (95% CI, 96.5–99.9), and ruled in 30% of patients with a positive predictive value (PPV) of 73% (95% CI, 66.1–79). In the validation cohort, AMI was the adjudicated final diagnosis in 88 of 1280 (6.9%) patients. These cutoffs ruled out 77.9% of patients with an NPV of 99.8% (95% CI, 99.3–100) and sensitivity of 97.7% (95% CI, 92.0–99.7), and ruled in 5.8% of patients with a PPV of 77% (95% CI, 65.8–86) in the validation cohort.

CONCLUSIONS
Safety and efficacy of the l hs-cTnI-Access 0/2-h algorithm for triage toward rule-out or rule-in of AMI are very high.

TRIAL REGISTRATION
APACE, NCT00470587; ADAPT, ACTRN1261100106994; IMPACT, ACTRN12611000206921.
An Intact ACTH LC-MS/MS Assay as an Arbiter of Clinically Discordant Immunoassay Results
Authors: Shi Junyan , Dhaliwal Pawan , Zi Zheng Yu , Wong Terry , Straseski Joely A , Cervinski Mark A , Shajani-Yi Zahra , DeMarco Mari L 
Published: September 2019

Abstract

BACKGROUND
Measurement of plasma adrenocorticotropic hormone (ACTH) is key in the differential diagnosis of hypothalamic-pituitary-adrenal disorders. Two-site sandwich immunoassays dominate clinical testing of ACTH in North America; however, discordant results between manufacturers have been repeatedly reported. To resolve the discrepancy, we developed a liquid chromatography–tandem mass spectrometry (LC-MS/MS) assay for the intended measurand, biologically active intact ACTH (iACTH).

METHODS
The multiple reaction monitoring LC-MS/MS assay was designed to selectively measure full-length iACTH, as well as ACTH analogs and fragments (i.e., ACTH1–24 and ACTH18–39). Epitope assignment of the Roche Elecsys antibodies was performed by MALDI-TOF mass spectrometry. A method comparison between Roche Elecsys and Siemens Immulite ACTH immunoassays was performed and clinically concordant/discordant results identified. In a subset of these samples, the iACTH concentration was determined using the LC-MS/MS method.

RESULTS
The lower limit of the measuring interval of the iACTH LC-MS/MS assay was 9 pg/mL (2 pmol/L). The assay was linear from 9 to 1938 pg/mL (2 to 427 pmol/L). Epitope mapping revealed that the Roche capture and detection antibodies bound residues 9–12 and 36–39 of ACTH, respectively. The iACTH LC-MS/MS analysis demonstrated that for discordant results between 2 immunoassays studied, only the Roche results were highly positively correlated with the iACTH concentration.

CONCLUSIONS
Immunoprecipitation of biologically active ACTH molecules followed by LC-MS/MS analysis enabled selective detection of iACTH and relevant biologically active fragments in plasma. Applied to the investigation of clinically discrepant results, this method can act as an arbiter of the concentration of iACTH present.
Regional hemodynamic changes in nodular goiter
Authors: Ul'yanova A E , Yarchenkova L L 
Published: September 2019

The goal of the present study was to evaluate the clinical and diagnostic value of regional hemodynamic changes in the thyroid vessels and carotid beds in patients with different forms of nodular goiter in order to optimize further follow-up and treatment.
The study covered 120patients aged 25 to 40years (mean age 32.82±0.36 years) who had nodular goiter. A control group comprised 30 women comparable by age (mean age 32. 06±0. 44 years), who had a morphologically and functionally unchanged thyroid. After examined, the patients with nodular goiter were divided into group according to the identified morphological forms. Group 1 consisted of25 (20.8%) women (mean age 34.85±0.89 years) with signs of nodular malignancies; Group 2 included 35 (29.2%) patients (mean age 32.08±0.78years) with detected adenomas; Group 3 comprised 40 (33.3%) patients (mean age 33.6±1.08years) with colloidal nodules, and Group consisted 20 (16.7%) women (mean age 32.87±0.9 years) with signs of cysts. The study and comparison of the linear and volume parameters of arterial ducts to the euthyroid loves in nodular pathology were made, by taking into account the site of an abnormal focus and its morphological structure. The linear and volumetric bloodflow rates in the thyroid arteries ipsilaterally to the abnormal nodular of any morphological structure were found to be significantly higher (p < 0.05). Changes were revealed in blood flow parameters in the carotid bed in relation to the morphological structure of nodules.
Influence of genetic factors on the result of therapy for diffuse euthyroid goiter
Authors: Galkina N V , Troshina E A , Mazurina N V 
Published: September 2019

The purpose of the present study was to investigate a relationship between the distribution of genotypes of the polymorphic markers TSHR (rs3783949, A/C substitution), NIS (rs7250346, C/G substitution), DUOXI (rs2467825, A/G substitution), DUOX2 (rs71713669, G/T substitution), and TRO (rs!7091737, G/T substitution) genes and the result of treatment for diffuse euthyroid goiter (DEG) using two regimens: monotherapy with iodine preparations and combined therapy with iodine and levothyroxine.
To identify a more effective and safe treatment for DEG, the authors compared thyroid volume, the levels of pituitary thyroid-stimulating hormone and thyroid peroxidase antibodies in two groups: 1) monotherapy with KI (200 pg/day) (n = 40) and 1) combined therapy with KI (100 pg) + L-T4(lpg/kg/day) (n = 41). According to the result of treatment, each group was divided into 2 subgroups: "fair result" and "poor result" (the thyroid volume failed to achieve the normal range or continued to increase). Correlation analysis was made to assess a relationship between the polymorphism of the genes and the result of therapy for DEG.
There was a significant correlation between the distribution of genotypes of the polymorphic marker the TSHR gene and the result of treatment for DES in the monotherapy group: there were prevalent AA + AC and CC genotypes with fair and poor results, respectively. There was no significant correlation between the distribution of the genotypes of the study polymorphic markers and the result of treatment using the combined therapy. Thus, the result of treatment for DES via monotherapy with iodine preparations may depend on genetic factors.
Planejamento de Rede de Monitoramento de Estruturas Empregando-se LST (Laser Scanner Terrestre)
Authors: Gonçalves Évelin Moreira , Veiga Luis A. Koenig 
Published: September 2019

Neste trabalho, são apresentados os procedimentos realizados no projeto de uma rede de monitoramento geodésico de uma barragem, empregando-se Laser Scanner Terrestre (LST). A premissa de que o modelo final do objeto tridimensional monitorado é gerado através da concatenação de diversas nuvens de pontos, obtidas a partir de várias estações de observação, norteou a definição de alguns critérios considerados no planejamento da coleta de dados em campo com LST. A definição desses critérios se deu a partir de testes realizados com o Laser Scanner FARO FOCUS 3D 120, em 9 diferentes cenários. Nos quais foi analisada a influência que alguns parâmetros, como a resolução da nuvem de pontos e a distância do LST em relação ao objeto, podem exercer no resultado final do monitoramento. Desta forma foi possível propor três diferentes hipóteses para a rede, baseadas nesses critérios. Em um modelo digital 3D da barragem da Usina Hidrelétrica (UHE) Mauá, local para o qual foi realizado o estudo, simulou-se amostras de dados para cada uma das três hipóteses. Estes dados foram utilizados nas equações de propagação de erros, gerando as incertezas esperadas para os pontos objeto de cada cena. A análise incluiu também as incertezas posicionais em função do diâmetro do feixe laser. Por fim, foi eleita a rede que melhor atendeu as expectativas do monitoramento do ponto de vista das precisões e da funcionalidade de coleta de dados em campo.
SUNAT PEREMPUAN PADA MASYARAKAT BANJAR DI KOTA BANJARMASIN
Authors: Nurdiyana Tutung 
Published: September 2019

Tujuan artikel ini adalah untuk mendiskusikan khitan perempuan yang dikenal dengan female genital mutilation (FGM) pada masyarat Banjar dan bagaimana mereka menginterpretasikan khitan perempuan bagi kehidupan sosial mereka. Penelitian menggunakan metode etnografi. Hasil penelitian menunjukkan bahwa pada masyarakat Banjar khitan perempuan dilakukan dengan memotong atau menggores klitoris. Bagi masyarakat Banjar, khitan perempuan adalah perintah agama yang tabu dibicarakan. Tujuan khitan perempuan menurut mereka adalah untuk menyucikan si jabang bayi dan menjadikannya sebagai muslim. Disamping itu khitan perempuan juga dimaksudkan untuk menjaga kelangsungan fungsi reproduksi.The purpose of this study is to describe the practice of female genital mutilation (FGM) in Banjarese society and the view of Banjarees society about it and how they interpret the female genital Â mutilation for their social life. This research method used is ethnography. This research found that female genital mutilation executed to the infant under one year and the mutilation Â method is done by cutting or scratching parts of the clitoris. For Banjarese Â society, female genital mutilation is a tradition and religious command, a taboo issue that cannot be discussed and was thought Â to have the objectives to clean the infants before entering the area of moslemhood as a moslem and as endeavour to protect the continuity of reproduction function.
EKSISTENSI WADUK CACABAN SEBAGAI TEMPAT KEGIATAN WIRAUSAHA BAGI MASYARAKAT
Authors: Astuti Tri 
Published: September 2019

Masyarakat Kedungbanteng memanfaatkan Waduk Cacaban sebagai tempat kegiatan wirausaha. Masyarakat bergerak dalam bidang sektor informal karena dalam wilayah tersebut dimungkinkan hanya bermodalkan ketrampilan dan pendidikan yang minim. Tujuan penelitian ini adalah untuk menganalisis profil dan aktivitas pedagang di Waduk Cacaban yang sering tanpa ijin pemerintah. Penelitian dilakukan dengan observasi mendalam dan wawancara. Hasil penelitian menunjukkan masyarakat Kedungbanteng berdagang di Waduk Cacaban karena suatu anggapan bahwa Waduk Cacaban merupakan tanah warisan nenek moyang yang digunakan untuk tujuan kesejahteraan hidup mereka. Oleh karena itu, masyarakat merasa tidak memerlukan ijin resmi dari pihak pengelola Waduk ketika mereka membuka tempat usaha di waduk tersebut. Ketika petugas menertibkan keberadaan para pedagang, terkadang mereka tidak mengindahkan hal tersebut. Karena anggapan tersebut, ada pula keyakinan kalau ada orang dari luar daerah Kedungbanteng yang berjualan di tempat tersebut, usahanya tidak lancar dan akhirnya harus gulung tikar. Hal tersebut menujukan adanya kekuatan budaya dalam masyarakat bahwa Waduk Cacaban merupakan sebuah tempat yang diwariskan nenek moyang mereka khusus untuk masyarakat Kedungbanteng.Kedungbanteng community makes Cacaban Dam as a place of entrepreneurial activity. The community is engaged in informal sector where they only need minimal skills and education. The purpose of this study is to analyze the profile and activity in of merchants in Cacaban Dam who often do business without government approval. The study was conducted through in-depth observations and interviews. The results show the trade in Cacaban Reservoir occurred because of a presumption that the reservoir Cacaban is a heritage land used for the purpose of the welfare of the Kedungbanteng community. Therefore, people feel they do not require official permission from the management of the reservoir when they open a place of business in these reservoirs. When government officer disciplined the traders, sometimes they do not heed it. Because of these assumptions, there is also a belief that there are people from outside the area that sell in Cacaban dam will notÂ be smooth and finally had to go out of business. The case studies illustrates the force of culture in human life.
AJARAN SUNAN GESENG BAGI KEHIDUPAN KEAGAMAAN MASYARAKAT
Authors: Faelasofa Dina 
Published: September 2019

Tujuan penelitian ini adalah untuk menggambarkan pengaruh ajaran Sunan Geseng bagi kehidupan keagamaan masyarakat di wilayah Grabag Magelang. Sunan Geseng adalah seorang tokoh agama atau disebut wali yang menyebarkan agama Islam di wilayah Grabag, Kabupaten Magelang yang sampai sekarang ajaran-ajarannya masih dilaksanakan oleh masyarakat di wilayah Grabag, yang diwujudkan dalam kehidupan keagamaan yang dilakukan oleh masyarakat di wilayah komplek makam Sunan Geseng. Penelitian ini merupakan penelitian kualitatif dengan mengadopsi pola studi kasus. Data dikumpulkan dengan metode wawancara dan observasi. Hasil penelitian mengungkapkan beberapa fakta tentang kuatnya pengaruh ajaran Sunan Geseng terhadap kehidupan masyarakat Grabag Magelang. Contohnya, makam Sunan Geseng yang digunakan sebagai tempat wisata spiritual keagamaan, yang banyak dikunjungiÂ para peziarah. Selain itu ada tradisi selikuran yang dilaksanakan setahun sekali pada malam ke-21 bulan Ramadhan di kompleks makam Sunan Geseng. Juga masih terdapat kegiatan keagamaan masyarakat yang menganut ajaran Sunan Geseng seperti tradisi slametan, gendurenan, methoan, dan tradisi-tradisi yang lainnya. Hal lain yang menarik adalah banyak pondok pesantren yang sistem pengelolaan maupun pengajarannya serupa dengan pondok pesantren rintisan Sunan Geseng. Hal ini membuktikan teori sentimen kemasyarakatan yang menyatakan bahwa peristiwa sejarah masa lampau dan peninggalan-peninggalan Sunan Geseng menjadi dasar sentimen kemasyarakatan.The objective of this research is to describe the influence of Sunan Geseng religious teachings on the society of Grabag, Magelang. Sunan Geseng is a religious figure or called wali who spreaded Islam in Grabag region, Magelang. His religious teachings are still implemented and hold by the society in Grabag region, living inÂ Sunan Geseng cemetary area. The method used in this study is a qualitative research which also adopted the pattern of case study. Data was collected through interview and observation. Research results show the strong influence of Sunan Gesengâ€™s religious teaching is apparent in Grabag, Magelang. Among the indicators are the use of Sunan Gesengâ€™s cemetery as spiritual tourism site visited by people from many area. There is also selikuran tradition held annually at the 21st night of Ramadhan in Sunan Geseng cemetery area. There are also other rituals like slametan, gendurenan, and methoan. Another interesting thing is that many boarding schools still adopt the management system or learning process like those of Sunan Geseng. All of this enforce the society sentiment theory stating that historical memory in the the past and Sunan Geseng heritages are fondation for society sentiment.