bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does robot-assisted minimally invasive esophagectomy really have the advantage of lymphadenectomy over video-assisted minimally invasive esophagectomy in treating esophageal squamous cell carcinoma? A propensity score-matched analysis based on short-term outcomes
Authors: Deng H-Y , Luo J , Li S-X , Li G , Alai G , Wang Y , Liu L-X , Lin Y-D 
Published: November 2018

SUMMARY
This study aims to investigate advantages of robot-assisted minimally invasive esophagectomy (RAMIE) over video-assisted minimally invasive esophagectomy (VAMIE) in treating esophageal squamous cell carcinoma by applying propensity score-matched analysis. From April 2016 to January 2018, consecutive patients undergoing a McKeown RAMIE or VAMIE for esophageal squamous cell carcinoma were prospectively included for analysis. Baseline data, pathological findings, and short-term outcomes of the two groups (RAMIE group and VAMIE group) were collected and compared. Propensity score-matched analysis was applied to generate matched pairs for further comparison. Finally, we included a total of 151 patients (RAMIE group: 79 patients, VAMIE group: 72 patients) for analysis. In the analysis of unmatched cohort, RAMIE yielded a significantly larger number of total dissected lymph nodes (mean: 20.6 ± 8.8 vs. 17.9 ± 7.7; P = 0.048) and abdominal lymph nodes (mean: 9.5 ± 6.8 vs. 7.4 ± 5.1; P = 0.039) than VAMIE. However, there was no significantly different risk of major complications between the two groups. In the analysis of matched cohort, RAMIE still yielded a significantly larger number of total dissected lymph nodes (P = 0.006) and abdominal lymph nodes (P = 0.042) than VAMIE. There was still no increased risk of postoperative major complications in the RAMIE group compared to the VAMIE group. Moreover, RAMIE was found to yield significantly more left recurrent laryngeal nerve lymph nodes (mean: 1.0 ± 1.8 vs. 0.4 ± 0.8; P = 0.033) than VAMIE without increasing the risk of recurrent laryngeal nerve paralysis. Therefore, RAMIE may have the advantage of lymphadenectomy over VAMIE without increasing any risk of postoperative major complications. Further well-conducted studies, however, are needed to confirm our conclusions.
Valve-sparing aortic root and aortic arch replacement in a 5-year-old boy with Loeys–Dietz syndrome
Authors: Ajmi Houda , Arifa Nadia , Boughzela Essia , Ben Mime Lotfi 
Published: November 2018

Abstract
In this study, we describe the case of a 5-year-old boy who presumably presented with Loeys–Dietz syndrome. A huge aneurysm of the ascending aorta and the aortic arch extended beyond the left subclavian artery and was accompanied by a slight narrowing of the aortic isthmus.
Bringing it back from Mexico
Authors: Mason Peter , Pardo-Tomás José 
Published: November 2018

Abstract
I cinque libri delle piante of Pier’Antonio Michiel (1510–1576) are kept in the Biblioteca Marciana in Venice. Eleven of the 1,028 plant drawings contained in their five volumes stand out for their notable stylistic differences from the rest. The authors advance the hypothesis that these eleven drawings derive from the work of indigenous scribe-artists in the Valley of Mexico. In tracing the various series of copies of them that circulated between New Spain, the Iberian peninsula and Italy, they highlight the important role played in the production and transportation of copies by Marcantonio Da Mula (1506–1572), and suggest the Spanish nobleman Diego Hurtado de Mendoza (c.1503–1575) as the link between the Spanish court and Michiel’s native Venice.
Low-Fat Dietary Pattern and Cancer Mortality in the Women’s Health Initiative (WHI) Randomized Controlled Trial
Authors: Chlebowski Rowan T , Anderson Garnet L , Manson JoAnn E , Prentice Ross L , Aragaki Aaron K , Snetselaar Linda , Beresford Shirley A A , Kuller Lewis H , Johnson Karen , Lane Dorothy , Luo Juhua , Rohan Thomas E , Jiao Li , Barac Ana , Womack Catherine , Coday Mace , Datta Mridul , Thomson Cynthia A 
Published: November 2018

Abstract

Background
In the Women’s Health Initiative Dietary Modification trial, a low-fat dietary pattern reduced deaths after breast cancer. Mortality from other cancer sites has not been reported.

Methods
A low-fat dietary pattern influence on deaths from and after site-specific cancers was examined during 8.5 years (median) of dietary intervention and cumulatively during 17.7 years (median) of follow-up. A total 48 835 postmenopausal women, ages 50–79 years, were randomly assigned from 1993 to 1998 at 40 US clinical centers to dietary intervention (40%, n = 19 541 or a usual diet comparison group (60%, n = 29 294). Dietary intervention influence on mortality from protocol-specified cancers (breast, colon and rectum, endometrium and ovary), individually and as a composite, represented the primary analyses.

Results
During the dietary intervention period, a reduction in deaths after breast cancer (HR = 0.65 95% CI = 0.45 to 0.94, P = .02) was the only statistically significant cancer mortality finding. During intervention, the HRs for deaths after the protocol-specified cancer composite were 0.90 (95% CI = 0.73 to 1.10) and 0.95 (95% CI = 0.85 to 1.06) for deaths after all cancers. During 17.7 years of follow-up with 3867 deaths after all cancers, reduction in deaths after breast cancer continued in the dietary intervention group (HR = 0.85, 95% CI = 0.74 to 0.99, P = .03). However, no dietary intervention influence on deaths from or after any other cancer or cancer composite was seen.

Conclusions
A low-fat dietary pattern reduced deaths after breast cancer. No reduction in mortality from or after any other cancer or cancer composite was seen.
A method to determine the evolution history of the mean neutral Hydrogen fraction
Authors: Mondal Rajesh , Bharadwaj Somnath , Iliev Ilian T , Datta Kanan K , Majumdar Suman , Shaw Abinash K , Sarkar Anjan K 
Published: November 2018

ABSTRACT
The light-cone (LC) effect imprints the cosmological evolution of the redshifted 21-cm signal $T_{\rm b} (\hat{\boldsymbol {n}}, \nu)$ along the frequency axis that is the line-of-sight (LoS) direction of an observer. The effect is particularly pronounced during the epoch of reionization (EoR) when the mean hydrogen neutral fraction $\bar{x}_{\rm \rm{H\,{\small I}}}(\nu)$ falls rapidly as the universe evolves. The multifrequency angular power spectrum ${\mathcal {C}}_{\ell }(\nu _1,\nu _2)$ quantifies the entire second-order statistics of $T_{\rm b}(\hat{\boldsymbol {n}},\nu)$ considering both the systematic variation along ν due to the cosmological evolution and also the statistically homogeneous and isotropic fluctuations along all the three spatial directions encoded in $\hat{\boldsymbol {n}}$ and ν. Here, we propose a simple model where the systematic frequency (ν1, ν2) dependence of ${\mathcal {C}}_{\ell }(\nu _1,\nu _2)$ arises entirely due to the evolution of $\bar{x}_{\rm \rm{H\,{\small I}}}(\nu)$. This provides a new method to observationally determine the reionization history. Considering an LC simulation of the EoR 21-cm signal, we use the diagonal elements ν1 = ν2 of ${\mathcal {C}}_{\ell }(\nu _1,\nu _2)$ to validate our model. We demonstrate that it is possible to recover the reionization history across the entire observational bandwidth provided we have the value $\bar{x}_{\rm \rm{H\,{\small I}}}$ at a single frequency as an external input.
Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video
Authors: Hameed N U Farrukh , Wu Bin , Gong Fangyuan , Zhang Jie , Chen Hong , Wu Jinsong 
Published: November 2018

Abstract
Two techniques, the translongitudinal cerebral fissure and transfrontal cortical approach, can be employed to resect posterior cingulate gyrus tumors. We demonstrate the transcortical technique comprising of multimodal imaging guidance and awake brain mapping which enabled maximum safe resection of dominant cingulate gyrus glioma.
The patient, a 49-yr-old female, came to clinic after experiencing headache for a month. Initial magnetic resonance imaging (MRI) scans revealed a nonenhancing lesion of the left posterior cingulate gyrus. Three-dimensional magnetic resonance spectroscopy was used to analyze the choline/N-acetyl-aspartate index (CNI) which strongly suggested a low-grade glioma diagnosis.
In surgery, after creating a tailed bone window and dural opening, strip electrode was placed across the central sulcus for continuous motor evoked potential monitoring. Next, direct cortical stimulation was done to map functional cortical areas. The transcortical approach was chosen at this point because many veins hindered hemisphere retraction. Noneloquent cortical incisions were made and the tumor was carefully debunked with a cavitron ultrasonic surgical aspirator. The corpus callosum marked the deep end of dissection. Subcortical mapping combined with diffusion tensor imaging tractography-based navigation was performed to localize motor and language tracks. Intraoperative MRI evaluation confirmed a gross total resection. Pathological and molecular analysis revealed a World Health Organization Grade II IDH-wildtype Diffuse Astrocytoma diagnosis. Since the patient falls in high-risk group, she was also administered radiation and chemotherapy. Long-term cognitive evaluation follow-up of the patient showed she had good functional recovery with no obvious long-term deficits.
Informed patient consent was obtained.
Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-year Non-randomized Clinical Trial
Authors: Athinarayanan Shaminie J. , Adams Rebecca N. , Hallberg Sarah J. , McKenzie Amy L. , Bhanpuri Nasir H. , Campbell Wayne W. , Volek Jeff S. , Phinney Stephen D. , McCarter James P. 
Published: November 2018

ABSTRACTOBJECTIVEStudies on long-term sustainability of low-carbohydrate approaches to treat diabetes are limited. We aim to assess the effects of a continuous care intervention (CCI) on retention, glycemic control, weight, body composition, cardiovascular, liver, kidney, thyroid, inflammatory markers, diabetes medication usage and disease outcomes at 2 years in adults with type 2 diabetes (T2D).RESEARCH DESIGN AND METHODSAn open label, non-randomized, controlled study with 262 and 87 participants with T2D were enrolled in the CCI and usual care (UC) groups, respectively.RESULTSSignificant changes from baseline to 2 years in the CCI group included: HbA1c (−12% from 7.7±0.1%); fasting glucose (−18% from 163.67±3.90 mg/dL); fasting insulin (−42% from 27.73±1.26 pmol L-1); weight (−10% from 114.56±0.60 kg); systolic blood pressure (−4% from 131.7±0.9 mmHg); diastolic blood pressure (−4% from 81.8±0.5 mmHg); triglycerides (−22% from 197.2±9.1 mg/dL); HDL-C (+19% from 41.8±0.9 mg/dL), and liver alanine transaminase (−21% from 29.16±0.97 U/L). Spine bone mineral density in the CCI group was unchanged. Glycemic control medication use (excluding metformin) among CCI participants declined (from 56.9% to 26.8%, P=1.3×10-11) including prescribed insulin (−62%) and sulfonylureas (−100%). The UC group had no significant changes in these parameters (except uric acid and anion gap) or diabetes medication use. There was also significant resolution of diabetes (reversal, 53.5%; remission, 17.6%) in the CCI group but not in UC. All the reported improvements had p-values <0.00012.CONCLUSIONSThe CCI sustained long-term beneficial effects on multiple clinical markers of diabetes and cardiometabolic health at 2 years while utilizing less medication. The intervention was also effective in the resolution of diabetes and visceral obesity, with no adverse effect on bone health.TRIAL REGISTRATIONClinicaltrials.govNCT02519309
Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion
Authors: Rutkowski Timothy P. , Purcell Ryan H. , Pollak Rebecca M. , Grewenow Stephanie M. , Gafford Georgette M. , Malone Tamika , Khan Uswa A. , Schroeder Jason P. , Epstein Michael P. , Bassell Gary J. , Warren Stephen T. , Weinshenker David , Caspary Tamara , Mulle Jennifer Gladys 
Published: November 2018

AbstractThe 3q29 deletion confers increased risk for neuropsychiatric phenotypes including intellectual disability, autism spectrum disorder, generalized anxiety disorder, and a >40-fold increased risk for schizophrenia. To investigate consequences of the 3q29 deletion in an experimental system, we used CRISPR/Cas9 technology to introduce a heterozygous deletion into the syntenic interval on C57BL/6 mouse chromosome 16. mRNA abundance for 20 of the 21 genes in the interval was reduced by ~50%, while protein levels were reduced for only a subset of these, suggesting a compensatory mechanism. Mice harboring the deletion manifested behavioral impairments in multiple domains including social interaction, cognitive function, acoustic startle, and amphetamine sensitivity, with some sex-dependent manifestations. Additionally, 3q29 deletion mice showed reduced body weight throughout development consistent with the phenotype of 3q29 deletion syndrome patients. Of the genes within the interval, DLG1 has been hypothesized as a contributor to the neuropsychiatric phenotypes. However, we show that Dlg1+/- mice did not exhibit the behavioral deficits seen in mice harboring the full 3q29 deletion. These data demonstrate the following: the 3q29 deletion mice are a valuable experimental system that can be used to interrogate the biology of 3q29 deletion syndrome; behavioral manifestations of the 3q29 deletion may have sex-dependent effects; and mouse-specific behavior phenotypes associated with the 3q29 deletion are not solely due to haploinsufficiency of Dlg1.
A hybrid of WOA and mGWO algorithms for global optimization and analog circuit design automation
Authors: Majeed M.A. Mushahhid , Patri Sreehari Rao 
Published: November 2018

PurposeThis paper aims to resolve the sizing issues of analog circuit design by using proposed metaheuristic optimization algorithm.Design/methodology/approachThe hybridization of whale optimization algorithm and modified gray wolf optimization (WOA-mGWO) algorithm is proposed, and the same is applied for the automated design of analog circuits.FindingsThe proposed hybrid WOA-mGWO algorithm demonstrates better performance in terms of convergence rates and average fitness of the function after testing it with 23 classical benchmark functions. Moreover, a rigorous performance evaluation is done with 20 independent runs using Wilcoxon rank-sum test.Practical implicationsFor evaluating the performance of the proposed algorithm, a conventional two-stage operational amplifier is considered. The aspect ratios calculated by simulating the algorithm in MATLAB are later used to design the operational amplifier in Cadence environment using 180nm CMOS standard process.Originality/valueThe hybrid WOA-mGWO algorithm is tailored to improve the exploration ability of the algorithm by combining the abilities of two metaheristic algorithms, i.e. whale optimization algorithm and modified gray wolf optimization algorithm. To build further credence and to prove its profound existence in the latest state of the art, a statistical study is also conducted over 20 independent runs, for the robustness of the proposed algorithm, resulting in best, mean and worst solutions for analog IC sizing problem. A comparison of the best solution with other significant sizing tools proving the efficiency of hybrid WOA-mGWO algorithm is also provided. Montecarlo simulation and corner analysis are also performed to validate the endurance of the design.
Socio-economic sourcing: benefits of small business set-asides in public procurement
Authors: Hawkins Timothy , Gravier Michael , Randall Wesley S. 
Published: November 2018

PurposeSmall businesses are critical to economic health and encouraged in government spending by set-asides – annual small business sourcing goals that often are not attained. Little research has explored the negative and risky stigmas associated with small business sourcing.Design/methodology/approachThis research explores reduced transaction costs of small business sourcing to government buyers. A survey of 350 government source selections reveals lower transaction costs derived from lower perceived risk of receiving a bid protest and via more efficient source selection processes.FindingsContrary to common bias, the performance level of small businesses is no less than that of large business. Thus, small businesses engender lower transaction costs for correcting supplier’s performance. On the basis of these findings, managerial and theoretical implications are discussed.
The impacts of in-state procurement preference policies on the economy of South Carolina
Authors: Abutabenjeh Sawsan , Gordon Stephen , Mengistu Berhanu 
Published: November 2018

Purpose
This paper aims to answer the question: What are the impacts of implementing in-state procurement preference policies on the economy of the state of South Carolina?

Design/methodology/approach
Toevaluate the impacts, the following six economic indicators were analyzed: jobs, personal income, real disposable income, output (sales), gross state product and value added. The data were collected from the South Carolina Procurement Services Office and were then analyzed using the Regional Economic Model Policy Insight (REMI PI+) for economic forecasting and policy analysis. The results from the REMI PI+ showed that implementing in-state preference policies benefitted the state and its communities economically.

Findings
Specifically, from 2010 until 2017, the total economic impact of implementing preference policies generated $17m in total output, 135 total job-years, $10.22m in gross state product (GSP), $10.27m in value added, $7.52m in income and $5.14m in real disposable personal income. The impact on the wholesale trade industry was over $5m in total industry output and approximately 27 jobs-years. In the manufacturing sector, the total impact was over $4m in output and approximately 17 jobs-years. The impact on the construction industry was approximately $3m in output and approximately 30 jobs-years. Although the values of these economic indicators were very small compared to the size of the state economy, they did outweigh the direct cost of implementing preference policies, thus demonstrating that overall the in-state preference policies contributed to South Carolina’s economy. However, further research is warranted to identify more precisely the benefits and costs of implementing preference policies.
The development of corporate social responsibility in accounting research: evidence from Indonesia
Authors: Gunawan Juniati , SeTin SeTin 
Published: November 2018

PurposeThe purpose of this paper is to analyze accounting research developments in the area of corporate social responsibility (CSR) in Indonesia for the period 2012-2016. The focus of CSR literature review is on disclosures and not to examine CSR activities or programs.Design/methodology/approachThis study applied a descriptive approach to provide evidence on the major variables that have been examined in CSR research and what is the measurement used to measure CSR disclosures. The CSR research development was traced through mapping articles published in the international journal with the subject of category accounting (Schimago Journalrank quartile Q3 and Q4), and national journal (national accredited accounting journals, as well as the proceedings of National Symposium on Accounting [NSA]). A total of 5,971 articles were reviewed and resulted in 31 Indonesian CSR articles in accounting which are dominated by quantitative methods (93.5 per cent), and as many as 28 articles were analyzed.FindingsThe analyses result showed that (1) 75 per cent of CSR research were in the areas of financial accounting and capital markets, followed by tax accounting and corporate governance; (2) The most widely used variable associated with CSR was financial performance; which (3) More than 80 per cent of the CSR research used annual reports as the source of data with only 19.23 per cent using sustainability reports; (4) 65.38 per cent of the CSR disclosure measurement referred to used other CSR disclosure lists, other than the Global Reporting Initiative (GRI).Research limitations/implicationsThe study results are important as a basis for future studies to provide a platform for the analysis to cover the gap between CSR studies in the academic and business areas for not only Indonesia but also other countries. Comparative studies between countries will be essential for future research to provide empirical evidence on the development of CSR research in accounting fields.Practical implicationsThe study provides comprehensive pictures in how CSR disclosures have been analyzed in academic area so that practitioners in business field are able to understand the results on which variables are associated with CSR. Further, the practitioners could enhance their CSR implementations and reports to gain the utmost benefits for their business.Originality/valueThis study is considered as the first CSR literature review analyzed in accounting research publications. As CSR topics have been emerging developed in many field of studies, reviewing this topic in the accounting area resulted interesting findings. These findings are useful for not only Indonesia but also other countries. Further, this study provides platform to fill many gaps for future research in the topic of CSR in accounting field.
Kabbage: an innovative source of short-term business loans
Authors: Ozlanski Michael , Fleck Emma Marie 
Published: November 2018

Synopsis
New entrepreneurial businesses are one of the key drivers of innovation and economic development. However, one of their greatest obstacles is accessing capital, especially since they are often initially unprofitable and lack tangible assets in the first few years of operation. Since debt financing from banks can be difficult for them to obtain, their capacity for growth can be limited. This case introduces students to Kabbage, a company that reduced the barriers associated with start-up and microbusiness lending by using a fully automated, data-driven platform. Kabbage made instant decisions on whether these businesses should qualify for a line of credit by reviewing its clients’ electronic data, analyzed quickly and accurately using specific algorithms.

Research methodology
Given the applied nature of the case, the data were gleaned from a wide range of secondary sources, specifically popular business press which was verified for authenticity.

Relevant courses and levels
This case can be used in a variety of undergraduate courses. Some course examples include small business management, introduction to entrepreneurship or entrepreneurial finance.