bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standard reference values of the upper body posture in healthy young female adults in Germany: an observational study
Authors: Ohlendorf Daniela , Fisch Vanessa , Doerry Charlotte , Schamberger Sebastian , Oremek Gerhard , Ackermann Hanns , Schulze Johannes 
Published: August 2018

ObjectiveClassifications of posture deviations are only possible compared with standard values. However, standard values have been published for healthy male adults but not for female adults.DesignObservational study.SettingInstitute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe-University Frankfurt/Main.Participants106healthy female volunteers (21–30 years old; 25.1±2.7 years) were included. Their body weight ranged from 46 to 106 kg (60.3±7.9 kg), the heights from 1.53 to 1.82 m (1.69±0.06 m) and the body mass index from 16.9 kg/m² to 37.6 kg/m² (21.1±2.6 kg/m²).Outcome measuresA three-dimensional back scan was performed to measure the upper back posture in habitual standing. The tolerance ranges and CI were calculated. Group differences were tested by the Wilcoxon Mann-Whitney U test.ResultsIn normal posture, the spinal column was marginally twisted to the left, and the vertebrae were marginally rotated to the right. The kyphosis angle is larger than the lumbar angle. Consequently, a more kyphotic posture is observed in the sagittal plane. The habitual posture is slightly scoliotic with a rotational component (scapular depression right, right scapula marginally more dorsally, high state of pelvic right, iliac right further rotated anteriorly).ConclusionsHealthy young women have an almost ideally balanced posture with minimal ventral body inclination and a marginal scoliotic deviation. Compared with young males, women show only marginal differences in the upper body posture. These values allow a comparison to other studies, both for control and patient data, and may serve as guideline in both clinical practice and scientific studies.
Use of online promotion to encourage patient awareness of aspirin use to prevent heart attack and stroke
Authors: Southwell Brian G , Eder Milton , Finnegan John , Hirsch Alan T , Luepker Russell V , Duval Sue , Russell Carol , O’Byrne Sam 
Published: August 2018

BackgroundLiterature on health promotion evaluation and public understanding of health suggests the importance of investigating behaviour over time in conjunction with information environment trends as a way of understanding programme impact. We analysed population response to online promotion of an educational tool built by the Ask About Aspirin campaign in the USA to inform people about aspirin as a preventive aid.MethodsWe collected 156 weeks of time series data on audience behaviour, namely use of a self-assessment tool. We then used the Autoregressive Integrated Moving Average (ARIMA) modelling to predict that outcome as a function of paid search engine advertising, paid social media promotion and general search interest in aspirin.ResultsThrough ARIMA modelling of tool engagement data adjusted for outcome series autocorrelation, we found a significant effect of online promotional effort on audience behaviour. Total paid search advertising positively predicted weekly total of individuals who started using the self-assessment tool, coefficient=0.023, t=3.28, p=0.001. This effect did not appear to be an artefact of broader secular trends, as Google search data on the topic of aspirin use did not add explanatory power in the final model nor did controlling for general search interest eliminate the significant coefficient for paid search promotion.ConclusionResults hold implications both for educational tool development and for understanding health promotion campaign effects. We witnessed substantial but ephemeral effects on tool use as a function of paid search efforts, suggesting prioritisation of efforts to affect search engine results as a dissemination tactic.
Mother’s education and late-life disparities in memory and dementia risk among US military veterans and non-veterans
Authors: Vable Anusha M , Eng Chloe W , Mayeda Elizabeth Rose , Basu Sanjay , Marden Jessica R , Hamad Rita , Glymour M Maria 
Published: August 2018

BackgroundAdverse childhood socioeconomic status (cSES) predicts higher late-life risk of memory loss and dementia. Veterans of U.S. wars are eligible for educational and economic benefits that may offset cSES disadvantage. We test whether cSES disparities in late-life memory and dementia are smaller among veterans than non-veterans.MethodsData came from US-born men in the 1995–2014 biennial surveys of the Health and Retirement Study (n=7916 born 1928–1956, contributing n=38 381 cognitive assessments). Childhood SES was represented by maternal education. Memory and dementia risk were assessed with brief neuropsychological assessments and proxy reports. Military service (veteran/non-veteran) was evaluated as a modifier of the effect of maternal education on memory and dementia risk. We employed linear or logistic regression models to test whether military service modified the effect of maternal education on memory or dementia risk, adjusted for age, race, birthplace and childhood health.ResultsLow maternal education was associated with worse memory than high maternal education (β = −0.07 SD, 95% CI −0.08 to –0.05), while veterans had better memory than non-veterans (β = 0.03 SD, 95% CI 0.02 to 0.04). In interaction analyses, maternal education disparities in memory were smaller among veterans than non-veterans (difference in disparities = 0.04 SD, 95% CI 0.01 to 0.08, p = 0.006). Patterns were similar for dementia risk.ConclusionsDisparities in memory by maternal education were smaller among veterans than non-veterans, suggesting military service and benefits partially offset the deleterious effects of low maternal education on late-life cognitive outcomes.
An Accurate Illumination Model of Machined Surface Based on Micro-Image
Authors: Shi Weichao , Zheng Jianming , Li Yan , Li Xubo , An Qiannan 
Published: August 2018

This paper focused on the illumination model of machined surface based on micro-image. According to micro-image forming condition, the theory that the image brightness is related to the microfacet topography and surface reflection characteristics is presented. The distribution rule of micro-topography and reflection characteristics of sample surface is analyzed according to the measured data. An illumination mode of machined surface is established based on the analysis result, and the model parameters are obtained by using the simulated annealing algorithm. Verification results show that this proposed model can improve the simulation accuracy significantly and describe the lighting effect of machined surface. The research will provide a new idea and method for the 3D reconstruction.
The eccentric version of atom-bond connectivity index of tetra sheet networks
Authors: Imran Muhammad , Baig Abdul Qudair , Azhar Muhammad Razwan 
Published: August 2018

Among topological descriptor of graphs, the connectivity indices are very important and they have a prominent role in theoretical chemistry. The atom-bond connectivity index of a connected graph [Formula: see text] is represented as [Formula: see text], where [Formula: see text] represents the degree of a vertex [Formula: see text] of [Formula: see text] and the eccentric connectivity index of the molecular graph [Formula: see text] is represented as [Formula: see text], where [Formula: see text] is the maximum distance between the vertex [Formula: see text] and any other vertex [Formula: see text] of the graph [Formula: see text]. The new eccentric atom-bond connectivity index of any connected graph [Formula: see text] is defined as [Formula: see text]. In this paper, we compute the new eccentric atom-bond connectivity index for infinite families of tetra sheets equilateral triangular and rectangular networks.
Evolution of a cratonic basin: insights from the stratal architecture and provenance history of the Parnaíba Basin
Authors: Menzies L. A. , Carter A. , MacDonald David I. M. 
Published: August 2018

Abstract
The processes that govern formation and development of cratonic basins are poorly understood, both individually and as a class. The cratonic Silurian–Jurassic Parnaíba Basin in NE Brazil is less well-studied than North American examples such as Williston, Illinois and Michigan but offers an opportunity to study stratal architecture both in outcrop and the subsurface. Published stratigraphic compilations emphasize basin-wide unconformities separating layer-cake, basin-wide packages; analysis of geological maps indicates this interpretation is over-simplified, with at least 12 local unconformities, concentrated along the SW basin margin. Comparison of basin-margin and intrabasinal well-correlation panels shows that unconformities are more common in marginal areas, so the current exposure margins may have some validity as near-original margins. Palaeocurrents suggest a consistent SW–NE transport direction for the Serra Grande and lower Canindé groups. Supporting heavy mineral analysis from Silurian–Carboniferous strata on the SW and NE basin margins show that assemblages are dominated by ultra-stable zircon, tourmaline and rutile with minor amounts of staurolite, especially in the SW and older units. Tourmaline varietal results are remarkably consistent across the basin. U–Pb age spectra from detrital zircons are dominated by Neoproterozoic grains, with subsidiary Meso-Paleoproterozoic provenance. We infer that the source terrane was a medium-grade regionally metamorphosed mica schist, probably the Araguaia Fold Belt. These results are indicative of a large sediment routing system feeding material across an evolving crustal sag, analogous to observations from North American cratonic basins; this suggests that cratonic basins may not have strongly shaped or controlled the routing system.
A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma
Authors: Koay Eugene J. , Lee Yeonju , Cristini Vittorio , Lowengrub John S. , Kang Ya'an , Lucas F. Anthony San , Hobbs Brian P. , Ye Rong , Elganainy Dalia , Almahariq Muayad , Amer Ahmed M. , Chatterjee Deyali , Yan Huaming , Park Peter C. , Rios Perez Mayrim V. , Li Dali , Garg Naveen , Reiss Kim A. , Yu Shun , Chauhan Anil , Zaid Mohamed , Nikzad Newsha , Wolff Robert A. , Javle Milind , Varadhachary Gauri R. , Shroff Rachna T. , Das Prajnan , Lee Jeffrey E. , Ferrari Mauro , Maitra Anirban , Taniguchi Cullen M. , Kim Michael P. , Crane Christopher H. , Katz Matthew H. , Wang Huamin , Bhosale Priya , Tamm Eric P. , Fleming Jason B. 
Published: August 2018

Abstract

Purpose:
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with variable presentations and natural histories of disease. We hypothesized that different morphologic characteristics of PDAC tumors on diagnostic computed tomography (CT) scans would reflect their underlying biology.

Experimental Design:
We developed a quantitative method to categorize the PDAC morphology on pretherapy CT scans from multiple datasets of patients with resectable and metastatic disease and correlated these patterns with clinical/pathologic measurements. We modeled macroscopic lesion growth computationally to test the effects of stroma on morphologic patterns, hypothesizing that the balance of proliferation and local migration rates of the cancer cells would determine tumor morphology.

Results:
In localized and metastatic PDAC, quantifying the change in enhancement on CT scans at the interface between tumor and parenchyma (delta) demonstrated that patients with conspicuous (high-delta) tumors had significantly less stroma, higher likelihood of multiple common pathway mutations, more mesenchymal features, higher likelihood of early distant metastasis, and shorter survival times compared with those with inconspicuous (low-delta) tumors. Pathologic measurements of stromal and mesenchymal features of the tumors supported the mathematical model's underlying theory for PDAC growth.

Conclusions:
At baseline diagnosis, a visually striking and quantifiable CT imaging feature reflects the molecular and pathological heterogeneity of PDAC, and may be used to stratify patients into distinct subtypes. Moreover, growth patterns of PDAC may be described using physical principles, enabling new insights into diagnosis and treatment of this deadly disease.
Abemaciclib in Combination with Single-Agent Options in Patients with Stage IV Non–Small Cell Lung Cancer: A Phase Ib Study
Authors: Kim Edward S. , Kelly Karen , Paz-Ares Luis G. , Garrido Pilar , Jalal Shadia , Mahadevan Daruka , Gutierrez Martin , Provencio Mariano , Schaefer Eric , Shaheen Monte , Johnston Erica L. , Turner P. Kellie , Kambhampati Siva Rama Prasad , Beckmann Richard , Hossain Anwar , John William J. , Goldman Jonathan W. 
Published: August 2018

Abstract
Purpose: Abemaciclib, a dual inhibitor of cyclin-dependent kinases 4 and 6, has demonstrated preclinical activity in non–small cell lung cancer (NSCLC). A multicenter, nonrandomized, open-label phase Ib study was conducted to test safety, MTD, pharmacokinetics, and preliminary antitumor activity of abemaciclib in combination with other therapies for treatment in patients with metastatic NSCLC.
Patients and Methods: An initial dose escalation phase was used to determine the MTD of twice-daily oral abemaciclib (150, 200 mg) plus pemetrexed, gemcitabine, or ramucirumab, followed by an expansion phase for each drug combination. Pemetrexed and gemcitabine were administered according to label. The abemaciclib plus ramucirumab study examined two dosing schedules.
Results: The three study parts enrolled 86 patients; all received ≥1 dose of combination therapy. Across arms, the most common treatment-emergent adverse events were fatigue, diarrhea, neutropenia, decreased appetite, and nausea. The trial did not identify an abemaciclib MTD for the combination with pemetrexed or gemcitabine but did so for the combination of abemaciclib with days 1 and 8 ramucirumab (8 mg/kg). Plasma sample analysis showed that abemaciclib did not influence the pharmacokinetics of the combination agents and the combination agents did not affect abemaciclib exposure. The disease control rate was 57% for patients treated with abemaciclib–pemetrexed, 25% for abemaciclib–gemcitabine, and 54% for abemaciclib–ramucirumab. Median progression-free survival was 5.55, 1.58, and 4.83 months, respectively.
Conclusions: Abemaciclib demonstrated an acceptable safety profile when dosed on a continuous twice-daily schedule in combination with pemetrexed, gemcitabine, or ramucirumab. Abemaciclib exposures remained consistent with those observed in single-agent studies. Clin Cancer Res; 24(22); 5543–51. ©2018 AACR.
Development of a Tetravalent Anti-GPA33/Anti-CD3 Bispecific Antibody for Colorectal Cancers
Authors: Wu Zhihao , Guo Hong-Fen , Xu Hong , Cheung Nai-Kong V. 
Published: August 2018

Abstract
Despite progress in the treatment of colorectal cancer, curing metastatic colorectal cancer remains a major unmet medical need worldwide. Here, we describe a T-cell–engaging bispecific antibody (T-BsAb) to redirect polyclonal cytotoxic T cells to eradicate colorectal cancer. A33, a murine antibody specific for GPA33, was humanized to huA33 and reformatted to huA33-BsAb, based on a novel IgG(L)–scFv platform by linking the anti-CD3 huOKT3 scFv to the carboxyl end of the light chain. This T-BsAb was stably expressed in CHO cells and purified as a stable monomer by HPLC, retaining immunoreactivity by FACS through 30 days of incubation at 37°C. In vitro, it induced activation and expansion of unstimulated T cells and elicited potent T-cell–dependent cell-mediated cytotoxicity against colon and gastric cancer cells in an antigen-specific manner. In vivo, huA33-BsAb inhibited the colon and gastric cancer xenografts, in both subcutaneous and intraperitoneal tumor models. More importantly, both microsatellite instable and microsatellite stable colorectal cancer were effectively eliminated by huA33-BsAb. These preclinical results provide further support for the use of IgG(L)–scFv platform to build BsAb, and especially one targeting GPA33 for colorectal cancer. These preclinical results also support further development of huA33-BsAb as a potential immunotherapeutic. Mol Cancer Ther; 17(10); 2164–75. ©2018 AACR.
Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer
Authors: Yim Sun Young , Shim Jae-Jun , Shin Ji-Hyun , Jeong Yun Seong , Kang Sang-Hee , Kim Sang-Bae , Eun Young Gyu , Lee Dong Jin , Conner Elizabeth A. , Factor Valentina M. , Moore David D. , Johnson Randy L. , Thorgeirsson Snorri S. , Lee Ju-Seog 
Published: August 2018

Abstract
Hepatocellular carcinoma (HCC) is a heterogeneous disease. Mouse models are commonly used as preclinical models to study hepatocarcinogenesis, but how well these models recapitulate molecular subtypes of human HCC is unclear. Here, integration of genomic signatures from molecularly and clinically defined human HCC (n = 11) and mouse models of HCC (n = 9) identified the mouse models that best resembled subtypes of human HCC and determined the clinical relevance of each model. Mst1/2 knockout (KO), Sav1 KO, and SV40 T antigen mouse models effectively recapitulated subtypes of human HCC with a poor prognosis, whereas the Myc transgenic model best resembled human HCCs with a more favorable prognosis. The Myc model was also associated with activation of β-catenin. E2f1, E2f1/Myc, E2f1/Tgfa, and diethylnitrosamine (DEN)-induced models were heterogeneous and were unequally split into poor and favorable prognoses. Mst1/2 KO and Sav1 KO models best resemble human HCC with hepatic stem cell characteristics. Applying a genomic predictor for immunotherapy, the six-gene IFNγ score, the Mst1/2 KO, Sav1 KO, SV40, and DEN models were predicted to be the least responsive to immunotherapy. Further analysis showed that elevated expression of immune-inhibitory genes (Cd276 and Nectin2/Pvrl2) in Mst1/2 KO, Sav1 KO, and SV40 models and decreased expression of immune stimulatory gene (Cd86) in the DEN model might be accountable for the lack of predictive response to immunotherapy.
Implication: The current genomic approach identified the most relevant mouse models to human liver cancer and suggests immunotherapeutic potential for the treatment of specific subtypes. Mol Cancer Res; 16(11); 1713–23. ©2018 AACR.
How to Know You’ve Survived Death
Authors: White Claire , Kinsella Michael , Bering Jesse 
Published: August 2018

AbstractReports of people who have survived death have captured the attention of mainstream audiences. Why do these ideas enjoy persistent and widespread success in contemporary Western culture? Adopting a cognitive approach to the study of afterlife accounts and drawing upon our own research, we argue that mainstream survival narratives are popular because they provide convincing evidence that one has journeyed to another realm. Such accounts are convincing, in part, because they meet default cognitive assumptions about what human survival would look like if it were possible. We support this claim by highlighting recurring common themes in recounted episodes of near-death experiences and past life accounts and outlining how key findings in the cognitive science of religion, in conjunction with culturally situated accounts, can help scholars concerned with ideas about anomalous experiences to better understand their appeal.
Health and justice partnerships for young adults – when health and law unite in care
Authors: Ewais Tatjana , Banks Cate 
Published: August 2018

Background: Issues of health and law are closely connected in people with chronic illness but as yet there is little emphasis in current health services funding and planning on establishing formal links between these two important areas. Context: The Mater Young Adult Health Centre and Health Advocacy Legal Clinic partnership offers an example of an innovative and effective health–justice and multidisciplinary practice. Health and legal services are co-located in a purpose-built tertiary hospital for adolescents and young adults with complex health needs, which facilitates close collaboration between health and legal professionals and interdisciplinary work. Aim and objectives: In this paper, we explore young people’s health and well-being in a contemporary context of holistic care provided within a health–justice partnership in a tertiary hospital for young adults with chronic illness. Methods: Using illustrative examples, we describe the collaborative treatment model involving health and law professionals working in an interdisciplinary clinic. Findings: While we touch on the role of students in the clinic and the educational benefits for the them, our primary focus is on describing the integration of law and health as a model of care and the importance of growth and shift in the understandings of professionals. We provide examples of treatment, coordinated actions and successful outcomes in the well-being of three complex young people, their families and the community. Conclusion: We conclude by offering future visions of service expansion, both in terms of availability on-site as well as increased support.