Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta‐analysis of European, North American and Australian cohorts
Authors: Santos S , Voerman E , Amiano P , Barros H , Beilin LJ , Bergström A , Charles M‐A , Chatzi L , Chevrier C , Chrousos GP , Corpeleijn E , Costa O , Costet N , Crozier S , Devereux G , Doyon M , Eggesbø M , Fantini MP , Farchi S , Forastiere F , Georgiu V , Godfrey KM , Gori D , Grote V , Hanke W , Hertz‐Picciotto I , Heude B , Hivert M‐F , Hryhorczuk D , Huang R‐C , Inskip H , Karvonen AM , Kenny LC , Koletzko B , Küpers LK , Lagström H , Lehmann I , Magnus P , Majewska R , Mäkelä J , Manios Y , McAuliffe FM , McDonald SW , Mehegan J , Melén E , Mommers M , Morgen CS , Moschonis G , Murray D , Ní Chaoimh C , Nohr EA , Nybo Andersen A‐M , Oken E , Oostvogels AJJM , Pac A , Papadopoulou E , Pekkanen J , Pizzi C , Polanska K , Porta D , Richiardi L , Rifas‐Shiman SL , Roeleveld N , Ronfani L , Santos AC , Standl M , Stigum H , Stoltenberg C , Thiering E , Thijs C , Torrent M , Tough SC , Trnovec T , Turner S , van Gelder MMHJ , van Rossem L , von Berg A , Vrijheid M , Vrijkotte TGM , West J , Wijga AH , Wright J , Zvinchuk O , Sørensen TIA , Lawlor DA , Gaillard R , Jaddoe VWV 
Published: February 2019

ObjectiveTo assess the separate and combined associations of maternal pre‐pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.DesignIndividual participant data meta‐analysis of 39 cohorts.SettingEurope, North America, and Oceania.Population265 270 births.MethodsInformation on maternal pre‐pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.Main outcome measuresGestational hypertension, pre‐eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.ResultsHigher maternal pre‐pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31– 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain.ConclusionsMaternal pre‐pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre‐pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity.Tweetable abstractPromoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.