bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conclusion: Havens of Health or Habitats for the Prosperity Gospel?
Authors: Wellman James K. , Corcoran Katie E. , Stockly Kate J. 
Published: September 2019

Abstract
The dominant assessment of megachurches, in both popular culture and scholarship, is that they tend to be havens of commerce and exploitation, and purveyors of the prosperity gospel. After sifting through the data on members in twelve representative American megachurches, looking at people who were longtime members and leaders, those who were new members, and those that were just visiting, we found something quite different. We found wells of goodness, satisfaction, generosity, and inspiration. We found religious organizations that have a certain genius for meeting the needs of what Durkheim called homo duplex. Megachurches are organizations that meet the desire of humans to flourish as individuals and to do it in a group—an equipoise that is rare but deeply satisfying.
The Border
Authors: Schain Martin A. 
Published: September 2019

Abstract
This book is a comparative study of how and why border policy has become increasingly important, politicized, and divisive in Europe and the United States. It focuses on how border governance has emerged as an important focus of policy in itself, rather than merely contingent on trade and, above all, on immigration policy. New data indicate a massive increase of walls and barriers between countries after 2001. In our more globalized world, borders are back with a vengeance. However, at the same time that more controls have been established, the flow of people and the growth of trade have continued at an impressive rate. The claims by scholars and political actors of an emerging Fortress Europe and Fortress America have clearly been exaggerated. They express goals and intentions, rather than outcomes. The argument in this book is that the gap between objectives and outcomes should be understood as a result of the complex politics of the border and border control. Although there has been consistent support for harsher border control on both sides of the Atlantic, there has also been important, if more focused, support for more open borders and more permissive border control. If electoral politics often favor border restriction, the politics of policymaking can be more advantageous for groups that favor access. These are separate political tracks, the author maintains, but they are always in dynamic interaction.
Start with the Problem: Establishing Research Relevance with Integrative Public Administration
Authors: Carboni Julia L , Dickey Todd , Moulton Stephanie , O’keefe Sean , O’leary Rosemary , Piotrowski Suzanne J , Sandfort Jodi 
Published: September 2019

Abstract
A key question of each Minnowbrook has been how public administration scholarship can be relevant to practice (Carboni and Nabatchi 2019; Nabatchi and Carboni 2019; O’Leary, Van Slyke, and Kim 2010). This question remains salient today, as public administration scholarship is increasingly distant from the challenges identified by practitioners. Academic research agendas are often disconnected from the social issues and challenges of public governance. Field norms incentivize and exacerbate this cleavage. As a result, past calls for more practice-oriented scholarship lack widespread implementation. In this essay, we propose modest shifts in how academic research is conducted to link it with problems, issues, and opportunities identified by the public service practitioners and professional communities. We refer to this shift as Integrative Public Administration. We also identify and make suggestions about how to change some field level conditions that hamper the shift to Integrative Public Administration.
Diversification Through Trade*
Authors: Caselli Francesco , Koren Miklós , Lisicky Milan , Tenreyro Silvana 
Published: September 2019

AbstractA widely held view is that openness to international trade leads to higher income volatility, as trade increases specialization and hence exposure to sector-specific shocks. Contrary to this common wisdom, we argue that when country-wide shocks are important, openness to international trade can lower income volatility by reducing exposure to domestic shocks and allowing countries to diversify the sources of demand and supply across countries. Using a quantitative model of trade, we assess the importance of the two mechanisms (sectoral specialization and cross-country diversification) and show that in recent decades international trade has reduced economic volatility for most countries.
Nutritive value of enzyme-supplemented carinata meal for growing pigs1
Authors: Hong Jinsu , Lee Jung Wook , Pettersson Dan , Woyengo Tofuko A 
Published: September 2019

AbstractCarinata meal is increasingly available for livestock feeding. However, the effects of supplemental phytase and fiber degrading enzymes on nutritive value of carinata meal for pigs have not been reported. Objective of the study was to evaluate the standardized ileal digestibility (SID) of amino acid (AA), and digestible energy (DE) and net energy (NE) values of phytase- and fiber-degrading enzymes-supplemented carinata meal for growing pigs. Ten ileal-cannulated pigs (initial body weight = 53.9 ± 4.76 kg) were fed 4 diets in a replicated 4 × 4 Latin square design with two additional columns to give 10 replicates per diet. Diets included a corn-soybean meal (SBM)-based basal diet, basal diet with 25% carinata meal, basal diet with 25% carinata meal plus phytase at 2,000 FTU/kg and multi-carbohydrase at 0.2 g/kg, and in addition a nitrogen-free diet. The multicarbohydrase supplied 4 units of xylanase, 10 units of β-glucanase, and 1,000 units of pectinase per kilogram of diet. The ratio of corn to SBM and soybean oil in carinata meal-containing diets was identical to that in the corn-SBM-based basal diet to allow calculation of AA and energy digestibility of carinata meal by the difference method. On a dry matter basis, carinata meal contained 50.2% crude protein, 0.88% ether extract, 15.37% acid detergent fiber, 1.82% Lys, 0.96% Met, 1.89% Thr, and 0.64% Trp, respectively. The SID of Lys, Met, Thr, and Trp for carinata meal were 51.4%, 82.2%, 65.9%, and 85.9%, respectively. The DE and NE values for carinata meal were 3,427 and 1,828 kcal/kg of dry matter, respectively. Supplementation of a combination of phytase and multicarbohydrase did not affect the apparent ileal digestibility of AA and SID of AA for the corn-SBM-carinata meal-based diet, and for the carinata meal. However, the combination of phytase and multicarbohydrase did improve (P &lt; 0.05) apparent total tract digestibility, and DE and NE values for carinata meal by 9.4%, 9.5%, and 12.4%, respectively. In conclusion, the enzymes used in the current study could be added in carinata meal-based diets for growing pigs to improve the energy value.
Relationship Between Pregnancy-Associated Malaria and Adverse Pregnancy Outcomes: a Systematic Review and Meta-Analysis
Authors: Thompson Julie M , Eick Stephanie M , Dailey Cody , Dale Ariella P , Mehta Mansi , Nair Anjali , Cordero José F , Welton Michael 
Published: September 2019

AbstractBackgroundPregnancy-associated malaria (PAM) has been associated with adverse pregnancy outcomes like preterm birth (PTB) and low birthweight (LBW), which are among the leading causes of infant mortality globally. Rates of PTB and LBW are high in countries with a high burden of malaria. PAM may be a contributing factor to PTB and LBW, but is not well understood.MethodsWe conducted a systematic review and meta-analysis of studies examining the relationship between PAM and PTB or LBW using PubMed. The title and abstract of all studies were screened by two reviewers, and the full text of selected studies was reviewed to ensure they met inclusion criteria. Information regarding study characteristics and of PTB and LBW births among women with and without PAM was abstracted for included studies.ResultsOur search terms yielded 2237 articles, of which 18 met our final inclusion criteria. Eight studies examined associations between PAM and PTB, and 10 examined associations between PAM and LBW (population size ranging from 35 to 9956 women). The overall risk of LBW was 63% higher among women with PAM compared with women without PAM (95% CI = 1.48–1.80) and the risk of PTB was 23% higher among women with PAM compared with women without PAM (95% CI = 1.07–1.41).ConclusionsThese results indicate that infection with PAM is associated with PTB and LBW. Further understanding of the pathogenesis of disease and the immunologic changes that occur during pregnancy is essential for reducing the disproportional effects this disease has on this vulnerable population.
Physical activity and risk of breast and endometrial cancers: a Mendelian randomization study
Authors: Baurecht Hansjörg , Leitzmann Michael , O’Mara Tracy , Thompson Deborah J ,   the collaborators of the Endometrial Cancer Association Consortium, Teumer Alexander , Baumeister Sebastian E. 
Published: September 2019

AbstractImportanceThe causality of the association between physical activity and risk of breast and endometrial cancers is uncertain because available evidence is based exclusively on observational studies, which are potentially susceptible to confounding and reverse causation.ObjectiveTo investigate whether increased physical activity is causally associated with decreased risk of breast and endometrial cancers, using a two-sample Mendelian randomization study design.Design, Setting, and ParticipantsGenome-wide association studies of physical activity, breast cancer, and endometrial cancer, published up to April 31, 2019, were identified using PubMed and the GWAS catalog. Twelve single nucleotide polymorphisms (SNP) known at P < 5 × 10−8 to be associated with accelerometer-assessed or self-reported physical activity served as instrumental variables. Genetic summary data from four large consortia provided SNP-outcome associations [Breast Cancer Association Consortium; Discovery, Biology and Risk of Inherited Variants in Breast Cancer Consortium; Endometrial Cancer Association Consortium].Main Outcomes and MeasuresThe primary outcomes were risk of breast cancer and risk of endometrial cancer. Secondary outcomes were estrogen receptor positive (ER+) and ER-breast cancers. Odds ratios (ORs) and 95% confidence intervals (CIs) per mean acceleration in milli-gravities of accelerometer-assessed physical activity and per one standard deviation (1-SD) increase in metabolic-equivalent (MET)-minutes/week of self-reported moderate-to-vigorous physical activity were computed using the inverse variance weighted method. A series of sensitivity analyses addressed the potential impact of heterogeneity, pleiotropy, and outliers.ResultsSummary data were available for 122,977 breast cancers and 12,270 endometrial cancers. Genetic predisposition to increased accelerometer-assessed physical activity was associated with lower risk of breast and endometrial cancers. The associations (ORs [95% CI] per 1-SD increase in mean acceleration) were 0.88 (0.85-0.91) for breast cancer and 0.90 (0.83-0.97) for endometrial cancer. In addition, genetic predisposition to increased accelerometer-assessed physical activity was associated with lower risk of ER+ breast cancer. We found no evidence for an association between genetic predisposition to self-reported physical activity and risk of total breast cancer, breast cancer subtypes, or endometrial cancer.Conclusion and RelevanceThis first Mendelian randomization study shows that objectively-assessed physical activity plays a causal role in protecting against breast and endometrial cancers.
DNA-based long-lived reaction-diffusion patterning in a host hydrogel
Authors: Urtel Georg , Estevez-Torres André , Galas Jean-Christophe 
Published: September 2019

AbstractThe development of living organisms is a source of inspiration for the creation of synthetic life-like materials. Embryo development is divided into three stages that are inextricably linked: patterning, differentiation and growth. During patterning, sustained out-of-equilibrium molecular programs interpret underlying molecular cues to create well-defined concentration profiles. Implementing this patterning stage in an autonomous synthetic material is a challenge that at least requires a programmable and long-lasting out-of-equilibrium chemistry compatible with a host material. Here we show that DNA/enzyme reactions can create reaction-diffusion patterns that are extraordinary long-lasting both in solution and inside an autonomous hydrogel. The life-time and stability of these patterns - here traveling fronts and two-band patterns - are significantly increased by blocking parasitic side reactions and by dramatically reducing the diffusion coefficient of specific DNA sequences. Immersed in oil, hydrogels pattern autonomously with limited evaporation, but can also exchange chemical information from other gels when brought in contact. Our primitive metabolic material thus recapitulates two important properties of living matter: a certain degree of autonomy that makes each piece of material an ‘individual’ with its own metabolism and, at the same time, the capacity to interact with other ‘individuals’.
Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model
Authors: Proctor Elizabeth A. , Dineen Shauna M. , Van Nostrand Stephen C. , Kuhn Madison K. , Barrett Christopher D. , Brubaker Douglas K. , Yaffe Michael B. , Lauffenburger Douglas A. , Leon Lisa R. 
Published: September 2019

AbstractHeat stroke is a life-threatening condition characterized by loss of thermoregulation and severe elevation of core body temperature, which can cause organ failure and damage to the central nervous system. While no definitive test exists to measure heat stroke severity, immune challenge is known to increase heat stroke risk, although the mechanism of this increased risk is unclear. In this study, we used a mouse model of classic heat stroke to test the effect of immune challenge on pathology. Employing multivariate supervised machine learning to identify patterns of molecular and cellular markers associated with heat stroke, we found that prior viral infection simulated with poly I:C injection resulted in heat stroke presenting with high levels of factors indicating coagulopathy. Despite a decreased number of platelets in the blood, platelets are large and non-uniform in size, suggesting younger, more active platelets. Levels of D-dimer and soluble thrombomodulin were increased in more severe heat stroke, and in cases presenting with the highest level of organ damage markers D-dimer levels dropped, indicating potential fibrinolysis-resistant thrombosis. Genes corresponding to immune response, coagulation, hypoxia, and vessel repair were up-regulated in kidneys of heat-challenged animals, and these increases correlated with both viral treatment and distal organ damage while appearing before discernible tissue damage to the kidney itself. We conclude that heat stroke-induced coagulopathy may be a driving mechanistic force in heat stroke pathology, especially when exacerbated by prior infection, and that coagulation markers may serve as an accessible biomarker for heat stroke severity and therapeutic strategies.Key pointsA signature of pro-coagulation markers predicts circadian core body temperature and levels of organ damage in heat strokeChanges in coagulopathy-related gene expression are evidenced before histopathological organ damage
On a simple general principle of brain organization
Authors: Velazquez Jose L. Perez , Mateos Diego M. , Erra Ramon Guevara 
Published: September 2019

AbstractA possible framework to characterise nervous system dynamics and its organization in conscious and unconscious states is introduced, derived from a high level perspective on the coordinated activity of brain cell ensembles. Some questions are best addressable in a global framework and here we build on past observations about the structure of configurations of brain networks in conscious and unconscious states and about neurophysiological results. Aiming to bind some results together into some sort of coherence with a central theme, the scenario that emerges underscores the crucial importance of the creation and dissipation of energy gradients in brain cellular ensembles resulting in maximisation of the configurations in the functional connectivity among those networks that favour conscious awareness and healthy conditions. These considerations are then applied to indicate approaches that can be used to improve neuropathological syndromes.
Computationally Guided Design of Dipeptidyl Peptidase-4 Inhibitors
Authors: Reynolds Lauren C. , Connolly Morgan P. , Siegel Justin B. 
Published: September 2019

ABSTRACTThe Type 2 Diabetes Mellitus (T2DM) epidemic undoubtedly creates a need for the development of new pharmaceuticals. With the goal of generating new therapeutics for this disease, computational studies were conducted to design novel dipeptidyl peptidase-4 (DPP-4) inhibitors. Two candidates, generated by chemical intuition-driven design and bioisosteric replacement, were found to have better docking scores than anagliptin, a currently available diabetes medication.
Deep characterization of the protein lysine acetylation in human gut microbiome and its alterations in patients with Crohn’s disease
Authors: Zhang Xu , Ning Zhibin , Mayne Janice , Deeke Shelley A. , Walker Krystal , Farnsworth Charles L. , Stokes Matthew P. , Mack David , Stintzi Alain , Figeys Daniel 
Published: September 2019

AbstractMetagenomic and metaproteomic approaches have been used to study the composition and functions of the microbiota. However, no studies have examined post-translational modifications (PTM) on human microbiome proteins at the metaproteome level, and it remains unknown whether the microbial PTM is altered or not in patient microbiome. Herein we used anti-acetyl-lysine (Kac) antibody enrichment strategy and mass spectrometry to characterize the protein lysine acetylation in human microbiome, which successfully identified 35,200 Kac peptides corresponding to 31,821 Kac sites from the microbial or host proteins in human gut microbiome samples. The gut microbial proteins exhibited Kac motifs that were distinct from those of human proteins. Functional analysis showed that microbial Kac proteins were significantly enriched in energy production and abundant in enzymes related to transferases and oxidoreductases. Applying to the analysis of pediatric Crohn’s disease (CD) patient microbiome identified 52 host and 136 microbial protein Kac sites that were differentially abundant in CD versus controls. Interestingly, most of the decreased Kac sites in CD were derived from Firmicutes and most of the increased sites were derived from Bacteroidetes. Forty-six out of the 52 differentially abundant human protein Kac sites were increased in CD patients, including those on calprotectin, lactotransferrin and immunoglobulins. Taken together, this study provides an efficient approach to study the lysine acetylation in microbiome and revealed taxon-specific alterations in the lysine acetylome as well as changes in host protein acetylation levels in intestinal samples during the on-set of disease in CD patients.
Computational discovery of hidden breaks in 28S ribosomal RNAs across eukaryotes and consequences for RNA Integrity Numbers
Authors: Natsidis Paschalis , Schiffer Philipp H. , Salvador-Martínez Irepan , Telford Maximilian J. 
Published: September 2019

ABSTRACTIn some eukaryotes, a ‘hidden break’ has been described in which the 28S ribosomal RNA molecule is cleaved into two subparts. The break is common in protostome animals (arthropods, molluscs, annelids etc.) but a break has also been reported in some vertebrates and non-metazoan eukaryotes. We present a new computational approach to determine the presence of the hidden break in 28S rRNAs using mapping of RNA-Seq data. We find a homologous break is present across protostomes although has been lost in a small number of taxa. We show that rare breaks in vertebrate 28S rRNAs are not homologous to the protostome break. A break is found in just 4 out of 331 species of non-animal eukaryotes studied and three of these are located in the same position as the protostome break suggesting a striking instance of convergent evolution. RNA Integrity Numbers (RIN) rely on intact 28s rRNA and will be consistently underestimated in the great majority of animal species with a break.
Aging-associated alterations in the mammary gland revealed by single-cell RNA sequencing
Authors: Li Carman Man-Chung , Shapiro Hana , Tsiobikas Christina , Selfors Laura , Chen Huidong , Gray G. Kenneth , Oren Yaara , Pinello Luca , Regev Aviv , Brugge Joan S. 
Published: September 2019

AbstractAging of the mammary gland is closely associated with increased susceptibility to diseases such as cancer, but there have been limited systematic studies of aging-induced alterations within this organ. We performed high-throughput single-cell RNA-sequencing (scRNA-seq) profiling of mammary tissues from young and old nulliparous mice, including both epithelial and stromal cell types. Our analysis identified altered proportions and distinct gene expression patterns in numerous cell populations as a consequence of the aging process, independent of parity and lactation. In addition, we detected a subset of luminal cells that express both hormone-sensing and alveolar markers and decrease in relative abundance with age. These data provide a high-resolution landscape of aging mammary tissues, with potential implications for normal tissue functions and cancer predisposition.
The impact of consumption value on consumer behaviour
Authors: Muhamed Ariff Azly , Ab Rahman Mohd Nizam , Mohd Hamzah Firdaus , Che Mohd Zain Che Rosmawati , Zailani Suhaiza 
Published: September 2019

PurposeThe purpose of this paper is to investigate the influence of halal concern as well as emotional and epistemic values on consumer behaviour in the choice and purchase of halal-certified food supplies.Design/methodology/approachThis study used a quantitative methodology of convenience sampling to collect survey data from 1,550 Muslim respondents in Malaysia. It also employed multiple regressions by covariance-based structural equation modelling in the data analysis as well as in the validation of the proposed model.FindingsThe empirical results showed that the importance of halal certification had the highest impact on consumer choice behaviour, particularly in the purchase of halal-certified food supplies. Also, epistemic and emotional values were both statistically significant in terms of their influence on the consumer decision-making process.Research limitations/implicationsThe results emphasize the importance of enhancing the hedonic (halal concern and emotional value) aspect as a way for the halal food industries to obtain an added value advantage for their products and services.Originality/valueThis paper is the first to employ an empirical approach to consider the halal sentiment as a determinant of consumer purchasing behaviour in the context of halal-certified food supplies.