bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Survey of Patient Care Handoff and Sign-Out Practices Among Podiatric Surgical Residency Programs
Authors: Sansosti Laura E. , Crowell Amanda , Ellis-McConnell Whitney , Meyr Andrew J. 
Published: April 2018

Background:
A patient “handoff,” or the “sign-out” process, is an episode during which the responsibility of a patient transitions from one health-care provider to another. These are important events that affect patient safety, particularly because a significant proportion of adverse events have been associated with a relative lack of physician communication. The objective of this investigation was to survey podiatric surgical residency programs with respect to patient care handoff and sign-out practices.

Methods:
A survey was initially developed and subsequently administered to the chief residents of 40 Council on Podiatric Medical Education–approved podiatric surgical residency programs attempting to elucidate patient care handoff protocols and procedures and on-call practices.

Results:
Although it was most common for patient care handoffs to occur in person (60.0%), programs also reported that handoffs regularly occurred by telephone (52.5%) and with no direct personal communication whatsoever other than the electronic passing of information (50.0%). In fact, 27.5% of programs reported that their most common means of patient care handoff was without direct resident communication and was instead purely electronic. We observed that few residents reported receiving formal education or assessment/feedback (17.5%) regarding their handoff proficiency, and only 5.0% of programs reported that attending physicians regularly took part in the handoff/sign-out process. Although most programs felt that their sign-out practices were safe and effective, 67.5% also believed that their process could be improved.

Conclusions:
These results provide unique information on a potentially underappreciated aspect of podiatric medical education and might point to some common deficiencies regarding the development of interprofessional communication within our profession during residency training.
Adoção Homoparental, um direito omitido, reivindicado por famílias invisíveis
Authors: Filho Adilson Lucio da Silva 
Published: April 2018

<p dir="ltr"><span>Resumo</span></p><span><span><br /></span></span><p dir="ltr"><span>O presente artigo tem como proposta, contribuir para a compreensão sobre a adoção por famílias homoafetivas através de um levantamento bibliográfico, revisando outras produções científicas e literaturas no campo da psicologia e direito. Propondo uma reflexão sobre as novas maneiras de se pensar em famílias, respeitando suas diversas possibilidades de configurações e suas interações com a sociedade, reconhecendo a importância de se preservar as estruturas e os estilos de vida de cada indivíduo. O estudo trata ainda os principais impactos da omissão legal quanto a existência das famílias homoparentais, principalmente nas garantias de seus direitos, onde nos deparamos com um Estado omisso e uma série de projetos, como o estatuto da família, por exemplo, que além de limitar a entidade familiar ao núcleo formado por um homem, uma mulher e seus filhos, coloca em risco a adoção por casais do mesmo sexo, passando por cima do STF (Supremo Tribunal Federal) que já reconhece a união estável homoafetiva, negando o direito da igualdade e dignidade a famílias, além de diminuir as chances de crianças e adolescentes em situação de abrigo, serem adotadas e possuírem uma família.</span></p><span><span><br /></span></span><p dir="ltr"><span>Palavras-chave:</span><span> famílias, famílias homoparentais, adoção, omissão, igualdade.</span></p><span><span><br /><br /></span></span><p dir="ltr"><span>Abstract</span></p><span><span><br /></span></span><p dir="ltr"><span>This article aims to contribute to the understanding of adoption by gay families, by reviewing through scientific publications and other literatures of psychology and rights. Proposing a reflection on the new ways of thinking about families, respecting their different possibilities of settings and their interactions with society, recognizing the importance of preserving individuals’ structures and lifestyle. This study also deals with the main impacts of the legal omission regarding the existence of gay families, especially the guarantees of their rights, in which we stumble upon an omissive State and a number of projects, such as family statute, for instance, that besides limiting the family unit to a core formed by a man, a woman and their children, puts at risk the adoption by same-sex couples, going over the STF (Federal Supreme Court), what already recognizes the gay marriage, denying the right of equality and dignity to families, besides reducing the chances of children and adolescents in a shelter situation being adopted and having a family.</span></p><span id="docs-internal-guid-acc031a1-9621-deea-f9c4-4a49fee815a3"><br /><span>Keywords:</span><span> families, gay families, adoption, omission, </span><span>equality.</span></span>
Violências, Justiça e Gênero: debates teóricos e aplicações práticas do Direito e dos Estudos de Gênero
Authors: Nichnig Claudia Regina , Bragagnolo Regina Ingrid , Ramos Maria Eduarda 
Published: April 2018

O presente artigo apresenta o Dossiê Viôlências, Justiça e Gênero formado pelos artigos apresentados pelas<span> autoras que participaram do Simpósio Temático ocorrido durante o 11º Seminário Internacional Fazendo Gênero e 13º Mundos de Mulheres, que aconteceu em Florianópolis, em agosto de 2017. A proposta foi agrupar trabalhos que articulassem as discussões dos estudos de Gênero com o Direito, a partir de discussões sobre as temáticas das <span>violências, debate extremamente necessário mais ainda incipiente no Brasil. Além de boas discussões teóricas em relação as violências e a aplicação do direito penal, os artigos também trazem discussões práticas sobre a aplicação da Lei Maria da Penha, nos mais diferentes recantos do país. Assim, as discussões sobre a implementação, aplicação e as práticas que visam o enfrentamento e a eliminação das violências, a partir de uma perspectiva dos estudos de gênero e feministas</span></span>
ANP32E induces tumorigenesis of triple‐negative breast cancer cells by upregulating E2F1
Authors: Xiong Zhenchong , Ye Liping , Zhenyu He , Li Fengyan , Xiong Yahui , Lin Chuyong , Wu Xianqiu , Deng Guangzheng , Shi Wei , Song Libing , Yuan Zhongyu , Wang Xi 
Published: April 2018

Triple‐negative breast cancer (TNBC) lacks expression of estrogen receptor (ER), progesterone receptor, and the HER2 receptor; it is highly proliferative and becomes the deadliest forms of breast cancer. Effective prognostic methods and therapeutic targets for TNBC are required to improve patient outcomes. Here, we report that acidic nuclear phosphoprotein 32 family member E (ANP32E), which promotes cell proliferation in mammalian development, is highly expressed in TNBC cells compared to other types of breast cancer. High expression of ANP32E correlates significantly with worse overall survival (OS; P < 0.001) and higher risks of disease recurrence (P < 0.001) in patients with TNBC. Univariate and multivariate Cox‐regression models show that ANP32E is an independent prognostic factor in TNBC. Furthermore, we discovered that ANP32E promotes tumor proliferation in vitro by inducing G1/S transition, and ANP32E inhibition suppresses tumor formation in vivo. By examining the expression of E2F1, cyclin E1, and cyclin E2, we discovered that ANP32E promotes the G1/S transition by transcriptionally inducing E2F1. Taken together, our study shows that ANP32E is an efficient prognostic marker, and it promotes the G1/S transition and induces tumorigenesis of TNBC cells by transcriptionally inducing E2F1.
Analyzing Regional Climate Change in Africa in a 1.5, 2, and 3°C Global Warming World
Authors: Weber T. , Haensler A. , Rechid D. , Pfeifer S. , Eggert B. , Jacob D. 
Published: April 2018

AbstractAt the 21st session of the United Nations Framework Convention on Climate Change Conference of the Parties (COP21) in Paris, an agreement to strengthen the effort to limit the global temperature increase well below 2°C was decided. However, even if global warming is limited, some regions might still be substantially affected by climate change, especially for continents like Africa where the socio‐economic conditions are strongly linked to the climatic conditions. In the paper we will discuss the analysis of indices assigned to the sectors health, agriculture, and infrastructure in a 1.5, 2, and 3°C global warming world for the African continent. For this analysis an ensemble of 10 different general circulation model‐regional climate model simulations conducted in the framework of the COordinated Downscaling EXperiment for Africa was investigated. The results show that the African continent, in particular the regions between 15°S and 15°N, has to expect an increase in hot nights and longer and more frequent heat waves even if the global temperature will be kept below 2°C. These effects intensify if the global mean temperature will exceed the 2°C threshold. Moreover, the daily rainfall intensity is expected to increase toward higher global warming scenarios and will affect especially the African Sub‐Saharan coastal regions.
The Sensitivity of Core Heat Flux to the Modeling of Plate‐Like Surface Motion
Authors: Langemeyer Sean M. , Lowman Julian P. , Tackley Paul J. 
Published: April 2018

AbstractThe generation of a magnetic field and the presence of tectonic plates are fundamental aspects of Earth's evolution. Viable dynamic models of terrestrial mantle convection therefore require the existence of heat transport from the core and a surface characterized by piecewise uniform surface velocity domains (i.e., plates). To test the compatibility of these two requirements, we varied energy input, rheology, and compositional heterogeneity in more than 70 mantle convection simulations. Calculations are performed in a spherical annulus geometry. By systematic investigation, we demonstrate that Earth‐like core heat flux can be obtained with self‐consistent model plates. We find that, given an initial condition where model parameters are chosen to ensure a mobile surface, the mobility is not strongly influenced when H is varied by up to a factor of three. Consequently, in spherical models with steady core temperatures and internal heating rates, the latter quantity can be used to regulate core heat flow to fit within the bounds inferred for terrestrial values. In contrast, core heat flow is strongly sensitive to model yield stress. We systematically vary thermal viscosity contrast, an intrinsic depth‐dependent viscosity and the depth‐dependence of a stress‐dependent rheology and analyze how each factor affects both surface velocities and core heat flux. Finally, we show that the addition of an intrinsically dense component comprising 5% or less of the mantle volume does not affect surface mobility or plateness, although it can have a profound impact on heat loss from the core.
Toward the Prediction of Bed Load Rating Curve Parameter Values: The Influence of Scale, Particle Size, and Entrainment Threshold
Authors: Gaeuman D. , Stewart R. L. , Pittman S. 
Published: April 2018

AbstractThree‐parameter bed load rating curves for fractional and total bed load transport rates are presented for 15 bed load data sets, and the relationships between the parameter values and physical attributes of the transport process are investigated. The coefficients in these rating curves represent the product of the bed load particle size raised to a power near 1.5 and the active channel width divided by the threshold for bed load entrainment raised to the power of the bed load rating curve exponent. Because bed load entrainment thresholds for different streams typically increase with stream scale faster than do mean bed load particle sizes, total bed load rating curves coefficients for different streams decrease with increasing stream size. In the case of fractional bed load, however, differences between the entrainment thresholds for different particle size fractions are relatively small, so coefficients in fractional bed load rating curves for a given stream usually increase with the particle size class considered. Much of the variability in bed load rating curve exponents appears to be due to estimation errors rather than physical conditions in the stream. The exponents can be overestimated when the sample data used to estimate them are confined to discharges near the sediment entrainment threshold, and the mathematical consequences of summing multiple fractional rating curves can inflate the exponents for mixed size sediments. We recognize channel geometry as another important factor determining the value of rating curve exponents, but the detailed topographic data needed to assess the role of channel form is unavailable for the most of the sampling locations analyzed in this study.
Creation of knowledge‐based planning models intended for large scale distribution: Minimizing the effect of outlier plans
Authors: Alpuche Aviles Jorge Edmundo , Cordero Marcos Maria Isabel , Sasaki David , Sutherland Keith , Kane Bill , Kuusela Esa 
Published: April 2018

AbstractKnowledge‐based planning (KBP) can be used to estimate dose–volume histograms (DVHs) of organs at risk (OAR) using models. The task of model creation, however, can result in estimates with differing accuracy; particularly when outlier plans are not properly addressed. This work used RapidPlan™ to create models for the prostate and head and neck intended for large‐scale distribution. Potential outlier plans were identified by means of regression analysis scatter plots, Cook's distance, coefficient of determination, and the chi‐squared test. Outlier plans were identified as falling into three categories: geometric, dosimetric, and over‐fitting outliers. The models were validated by comparing DVHs estimated by the model with those from a separate and independent set of clinical plans. The estimated DVHs were also used as optimization objectives during inverse planning. The analysis tools lead us to identify as many as 7 geometric, 8 dosimetric, and 20 over‐fitting outliers in the raw models. Geometric and over‐fitting outliers were removed while the dosimetric outliers were replaced after re‐planning. Model validation was done by comparing the DVHs at 50%, 85%, and 99% of the maximum dose for each OAR (denoted as V50, V85, and V99) and agreed within −2% to 4% for the three metrics for the final prostate model. In terms of the head and neck model, the estimated DVHs agreed from −2.0% to 5.1% at V50, 0.1% to 7.1% at V85, and 0.1% to 7.6% at V99. The process used to create these models improved the accuracy for the pharyngeal constrictor DVH estimation where one plan was originally over‐estimated by more than twice. In conclusion, our results demonstrate that KBP models should be carefully created since their accuracy could be negatively affected by outlier plans. Outlier plans can be addressed by removing them from the model and re‐planning.
Depdc5 knockdown causes mTOR‐dependent motor hyperactivity in zebrafish
Authors: de Calbiac Hortense , Dabacan Adriana , Marsan Elise , Tostivint Hervé , Devienne Gabrielle , Ishida Saeko , Leguern Eric , Baulac Stéphanie , Muresan Raul C. , Kabashi Edor , Ciura Sorana 
Published: April 2018

AbstractObjectiveDEPDC5 was identified as a major genetic cause of focal epilepsy with deleterious mutations found in a wide range of inherited forms of focal epilepsy, associated with malformation of cortical development in certain cases. Identification of frameshift, truncation, and deletion mutations implicates haploinsufficiency of DEPDC5 in the etiology of focal epilepsy. DEPDC5 is a component of the GATOR1 complex, acting as a negative regulator of mTOR signaling.MethodsZebrafish represents a vertebrate model suitable for genetic analysis and drug screening in epilepsy‐related disorders. In this study, we defined the expression of depdc5 during development and established an epilepsy model with reduced Depdc5 expression.ResultsHere we report a zebrafish model of Depdc5 loss‐of‐function that displays a measurable behavioral phenotype, including hyperkinesia, circular swimming, and increased neuronal activity. These phenotypic features persisted throughout embryonic development and were significantly reduced upon treatment with the mTORC1 inhibitor, rapamycin, as well as overexpression of human WT DEPDC5 transcript. No phenotypic rescue was obtained upon expression of epilepsy‐associated DEPDC5 mutations (p.Arg487* and p.Arg485Gln), indicating that these mutations cause a loss of function of the protein.InterpretationThis study demonstrates that Depdc5 knockdown leads to early‐onset phenotypic features related to motor and neuronal hyperactivity. Restoration of phenotypic features by WT but not epilepsy‐associated Depdc5 mutants, as well as by mTORC1 inhibition confirm the role of Depdc5 in the mTORC1‐dependent molecular cascades, defining this pathway as a potential therapeutic target for DEPDC5‐inherited forms of focal epilepsy.
Ge2Sb2Te5‐Based Tunable Perfect Absorber Cavity with Phase Singularity at Visible Frequencies
Authors: Sreekanth Kandammathe Valiyaveedu , Han Song , Singh Ranjan 
Published: April 2018

AbstractThe metal‐dielectric stacks‐based asymmetric Fabry–Perot (F–P) cavity systems have recently attracted much interest from the scientific community for realizing perfect absorption over the spectral bands from visible to infrared since they possess a lithography‐free design that is cost‐effective and scalable. This study experimentally demonstrates an asymmetric F–P cavity system for achieving tunable wide angle perfect absorption and phase singularity. The proposed system shows tunable multiband perfect absorption in the visible spectral region by incorporating an ultrathin layer of phase change material such as Ge2Sb2Te5 (GST) in the stack. The system shows multi‐narrowband perfect absorption with a maximum of 99.8% at a specific incident angle and polarization state when the GST is in amorphous phase; however, the absorption bands blueshift and broaden after switching to the crystalline phase. More importantly, the proposed scheme shows tunable phase singularity at the reflection‐less point. The obtained tunable perfect absorption and abrupt phase change are solely due to the presence of a highly absorbing ultrathin layer of GST in the stack. Experimental results are validated using an analytical simulation model based on a transfer matrix method. The proposed scheme could find potential applications in active photonic devices such as phase‐sensitive biosensors and absorption filters.
Microscale‐Patterned Graphene Electrodes for Organic Light‐Emitting Devices by a Simple Patterning Strategy
Authors: Chen Yang , Zhang Nan , Li Yun‐Fei , Bi Yan‐Gang , Yue Yuan‐Yuan , Feng Jing , Sun Hong‐Bo 
Published: April 2018

AbstractGraphene grown by chemical vapor deposition has attracted much attention in optoelectronic application due to its great potential as a large‐area 2D electrode material. However, the clean transfer and effective microscale patterning of graphene still remain great challenges for its use as the electrode in the optoelectronic devices. In this paper, a simple and reliable transfer‐pattern strategy is developed for the microscale‐patterned graphene electrode by using a photoresist as both supporting layer for the graphene transfer and photolithographic mask layer. The microscale‐patterned graphene electrodes transferred onto the desired substrates exhibit low surface roughness of 0.675 nm and mean sheet resistance of 444 Ω ◽−1. 25 µm line width patterned organic light‐emitting devices (OLEDs) arrays with high precision and uniform lighting area have proved the great potential of the transfer‐pattern strategy for high‐resolution OLEDs. Flexible and efficient OLEDs based on patterned graphene anodes can be realized by this strategy. Moreover, a scale of ≈2 in. patterned graphene well demonstrates the feasibility of the transfer‐pattern strategy for large‐area fabrication of the microscale‐patterned graphene.
Blue Thermally Activated Delayed Fluorescence‐Emitting Phosphine Oxide Hosts for Ultrasimple and Highly Efficient White Organic Light‐Emitting Diodes
Authors: Liang Qianqian , Han Chunmiao , Duan Chunbo , Xu Hui 
Published: April 2018

AbstractAmong a series of carbazole–diphenylphosphine oxide hybrids x2ArPO, blue thermally activated delayed fluorescence (TADF)‐emitting host m2tBCzPO with optimal electron‐withdrawing and steric effects is successfully constructed to demonstrate the superiority of blue TADF‐emitting host in adaptable exciton allocation for white light‐emitting diodes (WOLEDs), which realizes the negligible singlet–triplet splitting (ΔEST) of 0.02 eV, the photoluminescence quantum yield beyond 75% and the top‐rank external quantum efficiency (EQE) with the maxima of 13.8% and 22.2% from its blue and yellow devices. Its high‐efficiency blue TADF emission and excellent host characteristics are perfectly harmonized in its ultrasimple four‐layer WOLED with monodoping single‐emissive layer to support the state‐of‐the‐art performance, including EQE up to 21.3%, roll‐off within 10% at 1000 cd m−2, and excellent spectral stability.
Semitransparent Blue, Green, and Red Organic Solar Cells Using Color Filtering Electrodes
Authors: Kim Youngji , Son Jieun , Shafian Shafidah , Kim Kyungkon , Hyun Jerome K. 
Published: April 2018

AbstractColorful, semitransparent organic photovoltaic cells (OPVs) are increasing in demand due to their applicability in aesthetically fashioned power‐generating windows. The traditional method of generating different colors in OPVs has been through employing different active materials exhibiting distinct absorption spectra. This can complicate fabrication processes for production and cause deviations in device performance among differently colored OPVs. Herein, semitransparent and colorful OPVs with a single broadband‐absorbing active material of fixed thickness are demonstrated using Ag–TiOx–Ag color filters (CFs). The CF enables the OPV to transmit spectrally pure colors with peak transmission efficiencies surpassing 25%, and allows the colors to be freely tuned without disturbing the charge transport properties such that the device performance stays consistent. The CF not only functions as an effective electrode but as a mirror for light outside of the spectral transparency window. It is shown that when compared to a transparent OPV consisting of the same active layer material and thickness, CF‐integrated OPVs generate 32.38(±0.03)–34.10(±0.02)% more short‐circuit current. Such results point to a simple and convenient solution to achieving spectrally pure colors, moderate transmission efficiencies, decoupled optical and charge transport properties, and enhanced charge generation relative to a transparent OPV in semitransparent, colorful power‐generating windows.
Silicon‐based Bulky Group−Tuned Parallel Kinetic Resolution in Copper‐Catalyzed 1,3‐Dipolar Additions
Authors: Yuan Yang , Zheng Zhan‐Jiang , Li Li , Bai Xing‐Feng , Xu Zheng , Cui Yu‐Ming , Cao Jian , Yang Ke‐Fang , Xu Li‐Wen 
Published: April 2018

AbstractThe development of new strategies or reaction processes that tease new reactivity of functional groups continues to spur synthetic chemists toward innovative solutions that access new compounds. Herein, we find that the silicon‐based bulky group enables a 1,3‐dipolar addition−initiated parallel kinetic resolution (PKR) to occur unexpectedly, leading to the highly enantioselective synthesis of two structurally different types of amino acid derivatives via chemodivergent [3+2] cycloaddition reactions and tandem conjugate addition‐elimination reaction respectively. The resulting and structurally divergent enantioenriched amino acid derivatives that contain four contiguous stereogenic centers and an all‐carbon quaternary center were obtained with up to 99% ee with >95:1 dr and good yields.magnified image