bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative endometrial cancer treatments with electronic brachytherapy source
Authors: Lozares-Cordero Sergio , Font-Gómez Jose Antonio , Gandía-Martínez Almudena , Méndez-Villamón Agustina , Villa-Gazulla David , Miranda-Burgos Anabela , Alba-Escorihuela Verónica , Jiménez-Puertas Sara 
Published: September 2018

AbstractPurposeThis study is a dosimetric and acute toxicity comparison of endometrial cancer patients treated with either Axxent (Xoft, Inc., San José, CA, USA) electronic and interstitial brachytherapy versus interstitial high dose rate brachytherapy (HDRBT).Materials and MethodsBetween 2015 and 2017, 94 patients with postoperative endometrial cancer were treated in our centre with the Axxent electronic brachytherapy (eBT) system. The V150 and V200 are evaluated prospectively for each plan. The mean age of patients was 65.9 years (age range 33–84 years), with different tumour staging. Of the 94 patients, 37 received exclusive adjuvant brachytherapy (25 Gy in five sessions); the remaining patients received external beam radiotherapy (EBRT) with a regimen of 23 sessions of 2 Gy each to the entire pelvis, followed by eBT (15 Gy in three sessions). Additionally, the absorbed doses received by the organs at risk (OAR), urinary bladder, rectum and sigmoid colon were compared with HDRBT plans, evaluating D2cc, V50% and V35%. Median follow-up was done for each of the 94 patients to assess the toxicity of the treatment: vaginal mucosa toxicity, rectal and urinary toxicity; and results are presented for acute toxicity, toxicity at 1 month after the end of treatment and follow-up after 12 months for a portion of patients according to the Radiation Therapy Oncology Group (RTOG) toxicity criteria.ResultsThe doses in OAR for eBT plans were lower than that for HDRBT plans, both Ir-192 and Co-60 plans, whose doses were similar. The dose in bladder with eBT was 63.8% of the prescribed dose for D2cc versus 70.1% for HDRBT Ir-192, for V50% was 7.2% versus 12.7% and for V35% was 15.2% versus 28.2%. In rectum the D2cc was 61.2% versus 68.4%, for V50% was 7.9% versus 14.3% and for V35% was 16.7% versus 32%. Results demonstrated lower doses to OAR in all eBT plans. Acute toxicity in eBT was very low in cases of mucositis, with only one case of toxicity greater than grade 1, rectal toxicity and urinary toxicity; results at 1 month are equally good, toxicity symptoms disappeared and no relapses have occurred to date.ConclusionsThe results of treatment with the Axxent eBT unit for 94 patients are very good, as no recurrence has been observed and the toxicity of the treatment is very low. The increase in V150 and V200 has not produced an increase in vaginal mucosa toxicity, and the doses in the OAR are lower than in the plans implemented for HDRBT with Ir-192 or Co-60. eBT is a good alternative to treat endometrial cancer in centres without conventional HDR availability. To date, there are limited published studies reporting on outcomes from patients treated with eBT.
Less meat, more legumes: prospects and challenges in the transition toward sustainable diets in Sweden
Authors: Röös Elin , Carlsson Georg , Ferawati Ferawati , Hefni Mohammed , Stephan Andreas , Tidåker Pernilla , Witthöft Cornelia 
Published: September 2018

AbstractThe Western diet is characterized by high meat consumption, which negatively affects the environment and human health. Transitioning toward eating more plant-based products in Western societies has been identified as a key instrument to tackle these problems. However, one potential concern is that radically reducing meat in the current diet might lead to deficiencies in nutritional intake. In this paper, we explore a scenario in which meat consumption in Sweden is reduced by 50% and replaced by domestically grown grain legumes. We quantify and discuss the implications for nutritional intake on population level, consequences for agricultural production systems and environmental performance. The reduction in meat consumption is assumed to come primarily from a decrease in imported meat. We use data representing current Swedish conditions including the Swedish dietary survey, the Swedish food composition database, Statistics Sweden and existing life cycle assessments for different food items. At population level, average daily intake of energy and most macro- and micro-nutrients would be maintained within the Nordic Nutrition Recommendations after the proposed transition (e.g., for protein, fat, zinc, vitamin B12 and total iron). The transition would also provide a considerable increase in dietary fiber and some increase in folate intake, which are currently below the recommended levels. The transition scenario would increase total area of grain legume cultivation from 2.2% (current level) to 3.2% of Swedish arable land and is considered technically feasible. The climate impact of the average Swedish diet would be reduced by 20% and the land use requirement by 23%. There would be a net surplus of approximately 21,500 ha that could be used for bioenergy production, crop production for export, nature conservation, etc. Implementation of this scenario faces challenges, such as lack of suitable varieties for varying conditions, lack of processing facilities to supply functional legume-based ingredients to food industries and low consumer awareness about the benefits of eating grain legumes. In sum, joint efforts from multiple actors are needed to stimulate a decrease in meat consumption and to increase cultivation and use of domestically grown grain legumes.
Should We Tell the Recruiter That We Value a Good Work–Life	Balance?
Authors: Proost Karin , Verhaest Dieter 
Published: September 2018

Abstract. Although both employees and organizations increasingly realize the importance of a good work–life balance, it remains unclear how recruiters react when applicants mention a desire for balance on their CV. We conducted a between-subjects experiment (N = 96) in which one group of participants received a CV of an applicant who valued work–life balance versus a CV from which this information was omitted. Based on signaling theory and gender–role congruence theory, we suggested that mentioning balance on one’s CV would lead to less favorable recruitment outcomes through a lower work ethic, especially for men. The results supported this mediation hypothesis but, contrary to expectations, showed that the mediation effect was only significant for women.
Transient Response of the Gulf Stream to Multiple Hurricanes in 2017
Authors: Todd Robert E. , Asher Taylor G. , Heiderich Joleen , Bane John M. , Luettich Richard A. 
Published: September 2018

AbstractAutonomous underwater glider observations collected during and after 2017 Hurricanes Irma, Jose, and Maria show two types of transient response within the Gulf Stream. First, anomalously fresh water observed near the surface and within the core of the Gulf Stream offshore of the Carolinas likely resulted from Irma's rainfall being entrained into the Loop Current‐Gulf Stream system. Second, Gulf Stream volume transport was reduced by as much as 40% for about 2 weeks following Jose and Maria. The transport reduction had both barotropic and depth‐dependent characteristics. Correlations between transport through the Florida Straits and reanalysis winds suggest that both local winds in the Florida Straits and winds over the Gulf Stream farther downstream may have contributed to the transport reduction. To clarify the underlying dynamics, additional analyses using numerical models that capture the Gulf Stream's transient response to multiple tropical cyclones passing nearby in a short period are needed.
MODIS Retrievals of Cloud Effective Radius in Marine Stratocumulus Exhibit No Significant Bias
Authors: Witte Mikael K. , Yuan Tianle , Chuang Patrick Y. , Platnick Steven , Meyer Kerry G. , Wind Gala , Jonsson Haflidi H. 
Published: September 2018

AbstractSatellite retrievals of cloud effective radius re are frequently validated using aircraft in situ measurements. Past intercomparisons have found a significant bias toward larger remotely sensed re. Explanations for this bias have focused on retrieval algorithms and large‐scale heterogeneity, with in situ measurement uncertainty regarded as a minor factor. We compare Moderate Resolution Imaging Spectroradiometer re with in situ observations of marine stratocumulus clouds from three aircraft campaigns using a phase Doppler interferometer probe. Retrieved and in situ re typically agree within uncertainty in both nonprecipitating and drizzling conditions with no apparent systematic bias (mean bias of −0.22 μm, mean relative bias 3%). Agreement depends on the choice of in situ probe as well as microphysical context. We demonstrate that probes must adequately characterize the width of the drop size distribution to avoid systematic underestimation of re.
Fast Diffusion of Ultrarelativistic Electrons in the Outer Radiation Belt: 17 March 2015 Storm Event
Authors: Jaynes A. N. , Ali A. F. , Elkington S. R. , Malaspina D. M. , Baker D. N. , Li X. , Kanekal S. G. , Henderson M. G. , Kletzing C. A. , Wygant J. R. 
Published: September 2018

AbstractInward radial diffusion driven by ULF waves has long been known to be capable of accelerating radiation belt electrons to very high energies within the heart of the belts, but more recent work has shown that radial diffusion values can be highly event‐specific, and mean values or empirical models may not capture the full significance of radial diffusion to acceleration events. Here we present an event of fast inward radial diffusion, occurring during a period following the geomagnetic storm of 17 March 2015. Ultrarelativistic electrons up to ∼8 MeV are accelerated in the absence of intense higher‐frequency plasma waves, indicating an acceleration event in the core of the outer belt driven primarily or entirely by ULF wave‐driven diffusion. We examine this fast diffusion rate along with derived radial diffusion coefficients using particle and fields instruments on the Van Allen Probes spacecraft mission.
Adolescents With Suspected Intentional Overdose: Ethical Considerations in Determining Liver Transplant Candidacy
Authors: Triplett Kelli N. , Mayersohn Gillian S. , Pelley William , Desai Dev M. 
Published: September 2018

As the suicide rate for early adolescents has doubled in the past decade, pediatric liver transplant centers may more frequently encounter patients who present with acute liver failure secondary to an intentional ingestion of substances. The purpose of this article is to explore the ethical issues surrounding the determination of liver transplant candidacy for pediatric patients with suspected intentional ingestion of substances. Two case examples of pediatric patients who were evaluated for liver transplant after a suspected intentional ingestion of substances are explored. Evaluations to determine transplant candidacy in cases where an overdose is suspected, but unable to be confirmed, are typically complicated by time constraints due to medical urgency and potential biases by members of multidisciplinary transplant team members. More rigorous examination of long-term outcomes in pediatric patients who are post–liver transplant secondary to ingestion of substances is warranted. Until more robust pediatric outcome data are available, clinicians should continue to carefully weigh the risks and benefits of transplant while being guided by ethical principles. Pediatric psychologists working with potential liver transplant patients play a key role in ensuring that ethical principles are considered as a guide to inform transplant listing decisions. Implications for Impact Statement This article explores ethical issues that may arise in determining whether an adolescent should be listed for liver transplant after a suspected intentional overdose. The application of the ethical principles of distributive justice, nonmaleficence, beneficence, and autonomy is discussed. This article may assist pediatric psychologists, social workers, and other health care providers should they face similar ethical dilemmas when making solid organ transplant candidacy decisions.
Consumption of dairy, fruits and dark green leafy vegetables is associated with lower risk of adverse pregnancy outcomes (APO): a prospective cohort study in rural Ethiopia
Authors: Zerfu Taddese A. , Pinto Elisabete , Baye Kaleab 
Published: September 2018

Abstract
Background
Poor maternal nutrition during pregnancy is a leading modifiable risk factor associated with risks of adverse pregnancy outcomes (APO). Nevertheless, there is paucity of evidence if consumption of some food groups is associated with lower risk of APO, particularly in low-income settings. We aimed to determine whether consumption of some food groups is associated with lower risk of APOs such as: preterm birth (PTB), low-birth weight (LBW), and stillbirth in rural Central Ethiopia.

Methods
A multi-center (8 health centers) prospective cohort study, enrolling 432 pregnant women during their initial antenatal care visit, was employed. All mothers were then followed monthly (for a total of four visits) from enrollment to delivery. Midwives in respective health centers assessed dietary diversity using the Women’s individual dietary diversity score and evaluated birth outcomes following standard procedures. Logistic regression models were run to predict association of food groups with the APO.

Findings
Out of the 374 pregnant women who completed the study, one in five [74 (19.8%)] experienced at least one of the APO: 34 (9.1%) gave birth to LBW babies, 51(13.6%) had PTB and 17 (4.5%) experienced stillbirth. Poor or inconsistent consumption (<¾ assessments) of dark green leafy vegetables (adjusted odds ratio (AOR) = 2.01; 95% confidence interval (CI): 1.04–3.87), dairy products (AOR = 2.64; 95% CI: 1.11–6.30), and fruits and vegetables (AOR = 2.92; 95% CI: 1.49–5.67) were independently associated with higher APO risks. Whereas, being nonanemic at term (AOR = 0.24; 95% CI: 0.12–0.48) was independently associated with lower APO risks.

Conclusions
Poor or inconsistent consumption of dairy, dark green leafy vegetables and fruits were associated with higher risk of APOs. While community-based trials and mechanistic studies are needed to substantiate these findings, efforts to promote dietary diversity through increased consumption of fruits, vegetables and dairy may be beneficial in this and similar settings.
Prenatal exposure to TiO2 nanoparticles in mice causes behavioral deficits with relevance to autism spectrum disorder and beyond
Authors: Notter Tina , Aengenheister Leonie , Weber-Stadlbauer Ulrike , Naegeli Hanspeter , Wick Peter , Meyer Urs , Buerki-Thurnherr Tina 
Published: September 2018

AbstractEnvironmental factors are involved in the etiology of autism spectrum disorder (ASD) and may contribute to the raise in its incidence rate. It is currently unknown whether the increasing use of nanoparticles such as titanium dioxide (TiO2 NPs) in consumer products and biomedical applications may play a role in these associations. While nano-sized TiO2 is generally regarded as safe and non-toxic, excessive exposure to TiO2 NPs may be associated with negative health consequences especially when occurring during sensitive developmental periods. To test if prenatal exposure to TiO2 NPs alters fetal development and behavioral functions relevant to ASD, C57Bl6/N dams were subjected to a single intravenous injection of a low (100 µg) or high (1000 µg) dose of TiO2 NPs or vehicle solution on gestation day 9. ASD-related behavioral functions were assessed in the offspring using paradigms that index murine versions of ASD symptoms. Maternal exposure to TiO2 NPs led to subtle and dose-dependent impairments in neonatal vocal communication and juvenile sociability, as well as a dose-dependent increase in prepulse inhibition of the acoustic startle reflex of both sexes. These behavioral alterations emerged in the absence of pregnancy complications. Prenatal exposure to TiO2 NPs did not cause overt fetal malformations or changes in pregnancy outcomes, nor did it affect postnatal growth of the offspring. Taken together, our study provides a first set of preliminary data suggesting that prenatal exposure to nano-sized TiO2 can induce behavioral deficits relevant to ASD and related neurodevelopmental disorders without inducing major changes in physiological development. If extended further, our preclinical findings may provide an incentive for epidemiological studies examining the role of prenatal TiO2 NPs exposure in the etiology of ASD and other neurodevelopmental disorders.
NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR
Authors: Du Shangce , Miao Ji , Zhu Zhouting , Xu En , Shi Linsen , Ai Shichao , Wang Feng , Kang Xing , Chen Hong , Lu Xiaofeng , Guan Wenxian , Xia Xuefeng 
Published: September 2018

AbstractAnoikis is a type of programmed cell death induced by detachment from the extracellular matrix. In cancer cells, anoikis resistance is essential for cancer cell survival in blood circulation and distant metastasis. However, the mechanisms behind anoikis resistance of gastric cancer remain largely unknown. Herein, we demonstrate that NADPH oxidase 4 (NOX4) expression and reactive oxygen species (ROS) generation are upregulated in suspension gastric cell cultures compared with adherent cultures. Silencing of NOX4 decreases ROS generation and downregulates EGFR, sensitizing cells to anoikis. NOX4 overexpression upregulates ROS and EGFR levels and promotes anoikis resistance. NOX4 depletion inhibits gastric cancer survival in blood circulation and attenuates distant metastasis. NOX4 expression is correlated with EGFR expression in patients. In conclusion, induction of NOX4 expression by detachment promotes anoikis resistance of gastric cancer through ROS generation and downstream upregulation of EGFR, which is critical for the metastatic progression of gastric cancer.
Helicobacter pylori infection and inflammatory bowel disease: a crosstalk between upper and lower digestive tract
Authors: Yu Yang , Zhu Shengtao , Li Peng , Min Li , Zhang Shutian 
Published: September 2018

AbstractHelicobacter pylori has coexisted with humans for approximately 60,000 years and greater than 50% of the global population is infected with H. pylori. H. pylori was successfully cultured in vitro in 1983 and studies of H. pylori have achieved substantial advances over the last 35 years. Since then, H. pylori has been characterized as the primary pathogenic factor for chronic gastritis, peptic ulcer, and gastric malignancy. Numerous patients have received H. pylori eradication treatment, but only 1–2% of H. pylori-infected individuals ultimately develop gastric cancer. Recently, numerous epidemiological and basic experimental studies suggested a role for chronic H. pylori infection in protecting against inflammatory bowel disease (IBD) by inducing systematic immune tolerance and suppressing inflammatory responses. Here we summarize the current research progress on the association between H. pylori and IBD, and further describe the detailed molecular mechanism underlying H. pylori-induced dendritic cells (DCs) with the tolerogenic phenotype and immunosuppressive regulatory T cells (Tregs). Based on the potential protective role of H. pylori infection on IBD, we suggest that the interaction between H. pylori and the host is complicated, and H. pylori eradication treatment should be administered with caution, especially for children and young adults.
p53 cooperates with SIRT6 to regulate cardiolipin de novo biosynthesis
Authors: Li Meiting , Hou Tianyun , Gao Tian , Lu Xiaopeng , Yang Qiaoyan , Zhu Qian , Li Zhiming , Liu Chaohua , Mu Guanqun , Liu Ge , Bao Yantao , Wen He , Wang Lina , Wang Haiying , Zhao Ying , Gu Wei , Yang Yang , Zhu Wei-Guo 
Published: September 2018

AbstractThe tumor suppressor p53 has critical roles in regulating lipid metabolism, but whether and how p53 regulates cardiolipin (CL) de novo biosynthesis is unknown. Here, we report that p53 physically interacts with histone deacetylase SIRT6 in vitro and in vivo, and this interaction increases following palmitic acid (PA) treatment. In response to PA, p53 and SIRT6 localize to chromatin in a p53-dependent manner. Chromatin p53 and SIRT6 bind the promoters of CDP-diacylglycerol synthase 1 and 2 (CDS1 and CDS2), two enzymes required to catalyze CL de novo biosynthesis. Here, SIRT6 serves as a co-activator of p53 and effectively recruits RNA polymerase II to the CDS1 and CDS2 promoters to enhance CL de novo biosynthesis. Our findings reveal a novel, cooperative model executed by p53 and SIRT6 to maintain lipid homeostasis.
Aberrant activation of Notch-1 signaling inhibits podocyte restoration after islet transplantation in a rat model of diabetic nephropathy
Authors: He Yunqiang , Zhang Mei , Wu Ying , Jiang Hemin , Fu Hongxing , Cai Yong , Xu Ziqiang , Liu Chengyang , Chen Bicheng , Yang Tao 
Published: September 2018

AbstractSignaling abnormalities play important roles during podocyte injury and have been indicated as crucial events for triggering many glomerular diseases. There is emerging evidence demonstrating significant improvements in preventing renal injury and restoring podocytes after islet transplantation. However, whether signaling abnormalities affect the therapeutic efficacy of islet transplantation remain unclear. This study was established to investigate the impact of Notch-1 signaling activation on renal injury and podocyte restoration after islet transplantation. Experiments were performed in vivo and in vitro under conditions of diabetic nephropathy and high-glucose medium, respectively. Podocyte injury in vitro was induced by high-glucose concentration, and expression levels of genes associated with the Notch-1 pathway were also regulated by Jagged-1/FC and N-[N-(3,5-Difluorophenacetyl)-l-alanyl]- S-phenylglycine t-butyl ester (DAPT). Podocytes were co-cultured with islets to investigate the protective effect of islets in high-glucose conditions. Histopathological staining and transmission electron microscopy were performed to assess pathological changes in podocytes in glomeruli. The results from this study showed that Notch-1 signaling in podocytes was significantly decreased by functional islet cells in vivo and in vitro. Compared with the co-cultured group and transplanted group, highly activated Notch-1 signaling significantly moderated the effect of islets in affecting podocyte restoration and renal injury. Renal damage and podocyte injury were alleviated after DAPT treatment. Furthermore, the balance between apoptosis and autophagy was diverse under different treatments. All the data in this study showed that highly activated Notch-1 signaling could affect the therapeutic efficacy of islet transplantation on renal injury and podocyte restoration in high-glucose conditions. The balance between apoptosis and autophagy was also closely associated with the degree of podocyte restoration. This finding may suggest that the in vivo microenvironment plays a critical role in podocyte restoration after islet transplantation, which provides a promising and individual assessment and targeting treatment for different diabetic nephropathy patients after islet transplantation into the future.