bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of alpha actinin-3 gene (ACTN3) R577X and angiotensin converting enzyme (ACE) insertion / deletion gene polymorphisms in national and amateur Turkish athletes
Authors: Eroğlu Onur , Zileli Rayif , Nalbant M. Ali , Ulucan Korkut 
Published: May 2018

Studies to date showed the importance of alpha- actinin-3 (ACTN3) R577X and angiotensin converting enzyme (ACE) ID polymorphisms on determining athletic performance. Therefore, in this study, we aimed to examine polymorphisms given to Turkish athletes and compare them with sedentary individuals. Genomic DNAs were extracted from peripheral blood by using commercially available DNA isolation kit (Macherey-Nagel, NucleoSpin®, Germany). For this study, a total of 84 volunteers (23 national athletes, 27 amateur athletes and 34 sedentary controls) was recruited. ACE ID genotypes were determined by conventional polymerase chain reaction, and ACTN3 R577X polymorphisms by polymerase chain reaction- restriction fragment length polymorphism methodology. In ACTN3 R577X polymorphism, RX was the dominating genotype, and we detected no RR genotype in national athletes. (no RR genotype was detected in national athletes) X allele is more frequent in national athletes and R allele was more frequent in both amateur athletes and control group. II genotype was more frequent in national athletes and in control group, whereas DD genotype was more frequent in amateur athletes for ACE ID polymorphism. When we consider alleles, D allele was found more frequently in amateur athletes and control group whereas I allele was more frequent in national athletes in ACE ID polymorphism. For ACTN3, X allele was superior to R allele. ACTN3 R577X and ACE ID polymorphisms were important biomarkers in determining athletic performance. However, our results in Turkish athletes suggest that ACE D allele and ACTN3 X alleles may be beneficial to athletes potentially, regardless of the distance they perform.
Influence of medium composition and physical factors on enhanced production of endoglucanase by locally isolated fungal strain in solid state fermentation
Authors: Abdullah Roheena , Javed Peracha Bakhtawar , Nisar Kinza , Iqtedar Mehwish , Kaleem Afshan , Iftikhar Tehreema , Saleem Faiza , Naz Shagufta 
Published: May 2018

Endoglucanase is one of the most important enzymes of the cellulase group. Endoglucanase are involved in the catalytic hydrolysis of cellulose and plays a pivotal role in different sectors like pharmaceutical, textile, detergent, and food processing as well as paper and pulp industry. With consumers getting more and more aware of environmental issues, industries find enzymes as a better option over other chemical catalysts. In the current research different thermophilic fungal strains were isolated from the different sources. Qualitative screening was carried out on the basis of cellulose hydrolysis zone. The quantitative screening was carried out employing solid state fermentation. The fungal culture, showing highest EG potential was selected identified and assigned the code Aspergillus fumigatus BBT2. Different fermentation media were evaluated and M 2 containing wheat bran gave maximum EG production. The maximal enzyme productivity was recorded in 72 hours, 40°C, pH 5, inoculum size 1.5ml, and moisture content (1:1). Glucose (1%) and peptone (1%) were optimized as best carbon and nitrogen sources, respectively.
Complex yet fauna-deficient seagrass ecosystems at risk in southern Myanmar
Authors: Jones Benjamin L. , Cullen-Unsworth Leanne C. , Howard Robert , Unsworth Richard K.F. 
Published: May 2018

Abstract
Dependence on seafood across Southeast Asia is extensive. Myanmar is no exception, but the country’s provisioning marine ecosystems are threatened. Seagrass is one habitat that is frequently overlooked in management as an important fisheries resource, despite its nursery function. In Myanmar, research on seagrass habitats is particularly sparse, and as a result, our understanding of seagrass exploitation remains limited. In this study, we provide a baseline assessment of the seagrass-associated fish assemblages at four locations in the Myeik Archipelago in southern Myanmar using mono Baited Remote Underwater Video systems. Across the sites surveyed only 12 taxa of motile fauna were recorded. Relative to other regional and global studies, this figure is meagre. Our data adds to a growing literature suggesting that the marine ecosystems of Myanmar are in a worrying state. Despite the lack of recorded seagrass associated fauna, our study revealed minimal impacts to seagrass meadows from eutrophication or sedimentation, and the meadows included appeared to be healthy. The sites with the highest number of motile fauna were within Myanmar’s only National Marine Park offering some optimism for the effectiveness of protection, but further assessments are required to allow targeted management of Myanmar’s seagrass meadows.
Metrological traceability and harmonization of medical tests: a quantum leap forward is needed to keep pace with globalization and stringent IVD-regulations in the 21st century!
Authors: Cobbaert Christa , Smit Nico , Gillery Philippe 
Published: May 2018

Abstract
In our efforts to advance the profession and practice of clinical laboratory medicine, strong coordination and collaboration are needed more than ever before. At the dawn of the 21st century, medical laboratories are facing many unmet clinical needs, a technological revolution promising a plethora of better biomarkers, financial constraints, a growing scarcity of well-trained laboratory technicians and a sharply increasing number of International Organization for Standardization guidelines and new regulations to which medical laboratories should comply in order to guarantee safety and effectiveness of medical test results. Although this is a global trend, medical laboratories across continents and countries are in distinct phases and experience various situations. A universal underlying requirement for safe and global use of medical test results is the standardization and harmonization of test results. Since two decades and after a number of endeavors on standardization/harmonization of medical tests, it is time to reflect on the effectiveness of the approaches used. To keep laboratory medicine sustainable, viable and affordable, clarification of the promises of metrological traceability of test results for improving sick and health care, realization of formal commitment among all stakeholders of the metrological traceability chain and preparation of a joint and global plan for action are essential prerequisites. Policy makers and regulators should not only overwhelm the diagnostic sector with oversight and regulations but should also create the conditions by establishing a global professional forum for anchoring the metrological traceability concept in the medical test domain. Even so, professional societies should have a strong voice in their (inter-) national governments to negotiate long-lasting public policy commitment and funds for global standardization of medical tests.
Diagnostic accuracy in Family Medicine residents using a clinical decision support system (DXplain): a randomized-controlled trial
Authors: Martinez-Franco Adrian Israel , Sanchez-Mendiola Melchor , Mazon-Ramirez Juan Jose , Hernandez-Torres Isaias , Rivero-Lopez Carlos , Spicer Troy , Martinez-Gonzalez Adrian 
Published: May 2018

Abstract

Background:
Clinical reasoning is an essential skill in physicians, required to address the challenges of accurate patient diagnoses. The goal of the study was to compare the diagnostic accuracy in Family Medicine residents, with and without the use of a clinical decision support tool (DXplain http://www.mghlcs.org/projects/dxplain).

Methods:
A total of 87 first-year Family Medicine residents, training at the National Autonomous University of Mexico (UNAM) Postgraduate Studies Division in Mexico City, participated voluntarily in the study. They were randomized to a control group and an intervention group that used DXplain. Both groups solved 30 clinical diagnosis cases (internal medicine, pediatrics, gynecology and emergency medicine) in a multiple-choice question test that had validity evidence.

Results:
The percent-correct score in the Diagnosis Test in the control group (44 residents) was 74.1±9.4 (mean±standard deviation) whereas the DXplain intervention group (43 residents) had a score of 82.4±8.5 (p<0.001). There were significant differences in the four knowledge content areas of the test.

Conclusions:
Family Medicine residents have appropriate diagnostic accuracy that can improve with the use of DXplain. This could help decrease diagnostic errors, improve patient safety and the quality of medical practice. The use of clinical decision support systems could be useful in educational interventions and medical practice.
A novel one-pot approach to oxidative aromatization and bromination of pyrazolidin-3-one with HBr-H2O2system
Authors: Yang Shanguang , Liu Jingjing , Jin Zhudan , Tian Wei , Sun Hao , Wang Mingliang 
Published: May 2018

AbstractAn efficient and green one-pot method for the oxidative aromatization and bromination of pyrazolidin-3-ones under mild conditions with a HBr-H2O2system was developed. A mechanism was proposed.
Silencing of MED27 inhibits adrenal cortical carcinogenesis by targeting the Wnt/β-catenin signaling pathway and the epithelial-mesenchymal transition process
Authors: He Hongchao , Dai Jun , Yang Xiaoqun , Wang Xiaojing , Sun Fukang , Zhu Yu 
Published: May 2018

Abstract
This study aimed to explore the effect of MED27 on the expression of epithelial-mesenchymal transition (EMT)-related proteins and β-catenin in adrenal cortical carcinoma (ACC). The functional mechanism of MED27 on ACC processes was also explored. The expression of MED27 was assessed by quantitative real-time polymerase chain reaction (qRT-PCR). siRNA was utilized to knockdown the expression of MED27. CCK8 assays were performed to evaluate SW-13 cell proliferation. Transwell assays were performed to assess the invasion ability, and wound healing assays were utilized to detect migration. A tumor xenograft mouse model was established to investigate the impact of silencing MED27 on tumor growth and metastasis. MED27 was highly expressed in ACC tissues and cells. Down-regulation of MED27 induced ACC cell apoptosis, and significantly attenuated ACC cell proliferation, invasion and metastasis in vivo and in vitro. MED27 knockdown regulated the expression of EMT-related proteins and Wnt/β-catenin signaling pathway-related proteins. Our study investigated the function and mechanism of MED27 and validated that MED27 plays a negative role in ACC occurrence and progression and could be utilized as a new therapeutic target in ACC prevention and treatment.
First-line molecular therapies in the treatment of metastatic colorectal cancer – a literature-based review of phases II and III trials
Authors: Vogel Arndt , Kirstein Martha M. 
Published: May 2018

AbstractIntroduction:Metastatic colorectal cancer (mCRC) is one of the most common cancers and the second leading cause of cancer worldwide. With the improvement of systemic and operative therapies, median overall survival (mOS) reached 30 months or longer. Here, we will review the use of the anti-vascular endothelial growth factor (VEGF) and anti-epidermal growth factor receptor (EGFR) antibodies in combination with doublet and triplet chemotherapy in patients with borderline and primary unresectable mCRC.Methods:Phases II and III trials were included in investigating chemotherapy in the first-line in combination with an anti-VEGF(R) or anti-EGFR in a cohort of patients with mCRC.Results:The VEGF-antibody bevacizumab has improved progression-free survival (PFS) in several phase III trials in combination with a chemotherapy doublet. More recently, a higher efficacy has been demonstrated in combination with an intensified chemotherapy including 5-fluoropyrimidine (5-FU), oxaliplatin, and irinotecan within the phase III TRIBE study. Similarly, high resectability rates have been shown in the phase II Olivia trial for patients with liver-limited disease with an intensified chemotherapeutic regime. However, this increase in efficacy was accompanied by an increase in toxicity as well. The efficacy of the EGFR-antibodies cetuximab and panitumumab has been shown in several phase III trials, but their use is restricted to patients whose tumors are RAS wildtype (WT). The phase II trials, CELIM and PLANET, demonstrated a favorable long-term survival for patients with initially non-resectable colorectal liver metastases who respond to conversion therapy with EGFR-antibodies and undergo secondary resection. The CLGB and FIRE-3 trials delivered an inconsistent finding whether anti-VEGF or -EGFR treatment is the better option in the first-line setting. However, there is increasing evidence from post hoc analyses of prospective clinical trials that patients with left-sided tumors benefit from EGFR-directed combination therapy in terms of prolongation of OS and PFS compared with limited, if any, benefit for those with right-sided tumors.Conclusion:Both anti-VEGF- and anti-EGFR-directed therapies represent efficient treatment options for patients with mCRC in the first line. For patients with RAS WT, left-sided tumor anti-EGFR-based treatment is recommended. Intensified regimens can be offered initially to unresectable patients in order to achieve resectability at a price of higher toxicity.
Adverse neonatal outcomes and house prices in London
Authors: Dassios Theodore , Refaey Mazen , Kametas Nick , Bhat Ravindra , Greenough Anne 
Published: May 2018

Abstract

Objective
To explore whether the average price of houses per postcode sector [sector house average prices (SHAP)] is related to perinatal outcomes and whether gestational age would be lower and mortality higher in the least expensive areas compared to the most expensive.

Methods
All neonatal unit admissions at King’s College Hospital from 1/1/2012 to 31/12/2016 were reviewed. The SHAP was retrieved from the Land Registry and the population was divided in equal quintiles with quintiles 1 and 5 representing the most and least expensive areas, respectively. Gestational age and birth weight z-score were collected. Mortality was defined as death before discharge from neonatal care.

Results
Three thousand three hundred and sixty infants were included and divided in quintiles consisting of 672 infants. Gestational age was lower in quintile 5 compared to all other quintiles (adjusted P<0.001). Birthweight z-score was not significantly different between the quintiles. The SHAP was lower in the infants who died before discharge (n=92) compared to the SHAP of the infants who were alive at discharge (n=3268) (P<0.001). Infants of quintile 5 had 6 times higher risk of death before discharge from neonatal care compared to infants of quintile 1.

Conclusion
Low SHAPs were associated with poorer perinatal outcomes suggesting SHAP could potentially be used in perinatal populations to determine socio-economic status and associated outcomes.
The African Union Agenda 2063 and the Imperative of Democratic Governance
Authors: Nwebo Osy Ezechukwunyere 
Published: May 2018

Abstract
After more than five decades of the establishment of the Organization of African Unity (OAU) now the African Union (AU), Africa remains at a cross road in her struggle to grapple with the daunting challenges of achieving its core objectives of promoting sustainable development (SD) and economic integration, despite various earlier development initiatives and treaties in that regard. In analyzing the problem, this paper adopts the concept of law as instrument of social change and argues that at the heart of Africa’s missed development opportunities in the past lies the fundamental problem of democratic governance deficit. Indeed, weak governance and its associated political instability, insecurity and lack of peace hinder development and socio-cultural harmony. The paper further argues that there is an ineluctable linkage between democratic governance and sustainability of development and therefore presents the adoption of democratic governance method as the only sustainable way of successfully addressing Africa’s development challenges. In the final analysis, the paper concludes that the achievement SD and integration of the African continent within the framework of agenda 2063 must be predicated on the prioritization and promotion of democratic governance as its necessary adjunct.
Crystal structure of bis(N-(1-(pyrazin-2-yl)ethylidene)nicotinohydrazonato-κ3
N,N′,O)copper(II) C24H20N10O2Cu
Authors: Li Qingqing , Jiao Kaichuang , Xu Zhouqing 
Published: May 2018

Abstract
C24H20N10O2Cu, orthorhombic, Aba2 (no. 41), a = 12.2281(16) Å, b = 19.176(3) Å, c = 9.8689(13) Å, V = 2314.1(5) Å3, Z = 4, R
gt(F) = 0.0381, wR
ref(F
2) = 0.0752, T = 296(3) K.
Crystal structure of diaqua-dinitrato-k2
O,O′((Z)-N-((E)-1-(pyrazin-2-yl)ethylidene)nicotinohydrazonato-k3
N,N′,O)europium(II), C12H14N7O9Eu
Authors: Yaling He , Shilin Zeng , Peiling Zhang , Zhouqing Xu 
Published: May 2018

Abstract
C12H14N7O9Eu, monoclinic, P21/c (no. 14), a = 16.770(3) Å, b = 7.7185(16) Å, c = 15.165(3) Å, β = 108.409(3)°, V = 1862.5(7) Å3, Z = 4, R
gt(F) = 0.0174, wR
ref(F
2) = 0.0453, T = 296(2) K.
The crystal structure of benzenaminium 5,7-dihydroxy-4-oxo-2-phenyl-4H-chromene-8-sulfonate hydrate, C21H19NO8S
Authors: Li Wu-Wu , Zheng Min-Yan , Zhang Zun-Ting 
Published: May 2018

Abstract
C21H19NO8S, triclinic, P1̄ (no. 2), a = 7.2884(9) Å, b = 11.9469(15) Å, c = 12.2002(16) Å, α = 95.862(2)°, β = 106.659(2)°, γ = 93.189(2)°, V = 1008.4(2) Å3, Z = 2, R
gt(F) = 0.0659, wR
ref(F
2) = 0.1831, T = 296(2) K.
Crystal structure of semiconducting potassium poly[(μ2-tetraselenido-κ2
Se
1:Se
4)(μ2-pentaselenido-κ1
Se
1:Se
1)argentate(I)], K3AgSe9
Authors: Kim Kang-Woo , Kim Hyoungjoong 
Published: May 2018

Abstract
K3AgSe9, monoclinic, P21/c (no. 14), a = 11.094(2) Å, b = 9.7164(15) Å, c = 14.223(3) Å, β = 90.738(9)°, V = 1533.0(5) Å3, Z = 4, R
gt(F) = 0.0377, wR
ref(F
2) = 0.0832, T = 223(2) K.
Risperidone-induced type 2 diabetes presenting with diabetic ketoacidosis
Authors: Hui Fang Clarissa Ern , Rafey Mohammed Faraz , Cunningham Aine , Dinneen Sean F , Finucane Francis M 
Published: May 2018

Summary
A 28-year-old male presented with 2 days of vomiting and abdominal pain, preceded by 2 weeks of thirst, polyuria and polydipsia. He had recently started risperidone for obsessive-compulsive disorder. He reported a high dietary sugar intake and had a strong family history of type 2 diabetes mellitus (T2DM). On admission, he was tachycardic, tachypnoeic and drowsy with a Glasgow Coma Scale (GCS) of 10/15. We noted axillary acanthosis nigricans and obesity (BMI 33.2 kg/m2). Dipstick urinalysis showed ketonuria and glycosuria. Blood results were consistent with diabetic ketoacidosis (DKA), with hyperosmolar state. We initiated our DKA protocol, with intravenous insulin, fluids and potassium, and we discontinued risperidone. His obesity, family history of T2DM, acanthosis nigricans and hyperosmolar state prompted consideration of T2DM presenting with ‘ketosis-prone diabetes’ (KPD) rather than T1DM. Antibody markers of beta-cell autoimmunity were subsequently negative. Four weeks later, he had modified his diet and lost weight, and his metabolic parameters had normalised. We reduced his total daily insulin dose from 35 to 18 units and introduced metformin. We stopped insulin completely by week 7. At 6 months, his glucometer readings and glycated haemoglobin (HbA1c) level had normalised.

Learning points:

Risperidone-induced diabetic ketoacidosis (DKA) is not synonymous with type 1 diabetes, even in young white patients and may be a manifestation of ‘ketosis-prone’ type 2 diabetes (KPD).

KPD is often only confirmed after the initial presentation, when islet autoimmunity and cautious phasing out of insulin therapy have been assessed, and emergency DKA management remains the same.

As in other cases of KPD, a family history of T2DM and presence of cutaneous markers of insulin resistance were important clinical features suggestive of an alternative aetiology for DKA.
OPTIMAL ORGANOPROTECTION, CONTROL OF bLOOD PRESSURE AND METAbOLIC DISORDER WITH THE FIxED COMbINATION OF LISINOPRIL, AMLODIPINE AND ROSUVASTATIN IN SYSTEMIC HYPERTENSION
Authors: Nedogoda S. V. , Chumachek E. V. , Ledyaeva A. A. , Tsoma V. V. , Salasyuk A. S. , Smirnova V. O. , Hripaeva V. Yu. , Palashkin R. V. , Popova E. A. 
Published: May 2018

Aim. Evaluation of the ability of the fixed combination of lisinopril, amlodipine and rosuvastatin (Equamer) in achievement of additional angioprotection in patients with systemic arterial hypertension (AH) and high pulse wave velocity (PWV), regardless of previous antihypertensive therapy (AHT).Material and methods. To the open multicenter observational study 24 weeks duration, 60 patients included, taking double AHT during 6 months. All participants underwent ambulatory 24 hour blood pressure (BP) monitoring, applanation tonometry (augmentation index and central BP), pulse wave velocity assessment, laboratory tests (lipids, fasting glucose, insulin resistance index (HOMA), leptin, high sensitive C-reactive protein (hsCRP) before and after transition to the fixed combination of lisinopril, amlodipine and rosuvastatin (Equamer).Results. By the data from office BP measurement, after transition of patients from the double combinations to fixed combination of lisinopril, amlodipine and rosuvastatin, there was additional decrease of systolic BP (SBP) by 14,3% and diastolic BP (DBP) by 18,5%. By the data from ABPM, decrease of SBP was 16,1%, and DBP — 21,8%. Combination of lisinopril, amlodipine and rosuvastatin decreased PWV by 14,4%, augmentation index by 14,5%, central SBP by 8,1% (p<0,01 for all comparisons with baseline). Fixed combination of lisinopril, amlodipine and rosuvastatin made it to decrease low density lipoproteides by 44%, triglycerides by 36,1% and increase of high density lipoproteides by 10,3% (p<0,01 for all with baseline). Usage of combination of lisinopril, amlodipine and rosuvastatin showed significant decrease of insulin resistance, hsCRP and leptin levels.Conclusion. Fixed combination of lisinopril, amlodipine and rosuvastatin makes it to better control BP, improve vascular elasticity parameters (augmentation index, PWV, central BP) and facilitates the improvement of lipid and glucose metabolism, decrease of inflammation, leptin resistance in patients taking at baseline double antihypertensive therapy.
Alfabeto visual y caligrafía como herramienta terapéutica con personas con demencia temprana
Authors: López Méndez Lorena 
Published: May 2018

El Proyecto “Alfabeto Visual” Arte y Salud Alzhéimer, es un proyecto que pretende acercar la educación artística contemporánea a personas con demencia temprana a través de la caligrafía y los refranes, a sus familiares- cuidadores y personal sanitario. Permitiéndoles participar en una serie de actividades lúdicas, creativas y culturales. El taller forma parte del programa de educación artística diseñado e implementado durante el 2014 y 2015 en el Centro de Referencia Estatal de atención a personas con enfermedad de Alzhéimer y otras Demencias de Salamanca, dependiente del Instituto de Mayores y Servicios Sociales (IMSERSO). Los objetivos del programa están enfocados no sólo en mejorar la calidad de vida y preservar las capacidades cognitivas a través de la utilización del Arte como herramienta, sino también en sensibilizar a la sociedad, erradicando estigmas asociados a la enfermedad en fases incipientes, donde todavía el participante puede participar y comunicarse. Los resultados del programa nos permiten considerar que el Arte puede ofrecer una nueva oportunidad de aprendizaje y un soporte de ayuda terapéutica tanto individual como cooperativo, desarrollar habilidades cognitivas y funcionales, ampliar recursos emocionales y disfrutar de la experiencia, fortaleciéndose la seguridad y autoestima en sí mismos, ante la capacidad de formar parte activa del programa.