bluuebunny/crossref_metadata_2025_split huggingface dataset:
Una propuesta empírica de Creación de Cuadro de Mando para Pymes desde una interpretación estratégica de las Normas Internacionales de Información Financiera- NIIF
Authors: García Carvajal Santiago , Dueñas Robinson , Acuña Barrantes Henry 
Published: April 2019

Introducción: Hoy en día, surge la necesidad de crear y diseñar procedimientos que tienen como fin el funcionamiento del sistema empresarial a nivel universal, dentro de estos avances puede mencionarse las Normas Internacionales de Información Financiera, siendo estas las más discutidas y de considerable aplicación en todo el ámbito empresarial internacional.Metodología: se plantea una revisión de los procesos de convergencia de las normas estándares de contabilidad a las Normas Internacionales de Información Financiera, de tal forma que interprete las posibles consecuencias que podrían darse en la empresa en todas las disciplinas organizacionales sobre la plataforma de un cuadro de mando operativo, esto último corroborado por un análisis correlacional estadístico realizado a Pymes colombianas en SPSS. Resultados: en la elaboración del trabajo se han analizado los procedimientos de la NIIF para las PYMES adoptando dicha norma para preparar estados financieros en un cuadro de mando, dicho cuadro, es correlacional en la implementación del modelo en las Pymes, los resultados fueron más que probabilísticos. Conclusiones: lo anterior hace llegar a la conclusión de que es una herramienta de gran utilidad para cualquier compañía, el cambio contable que la adopción de la norma implica contempla criterios simplificados.
Cullin 1 is not associated with late-onset preeclampsia
Authors: Samara Tjam Diana , Liem Isabella Kurnia , Prijanti Ani Retno , Andrijono Andrijono 
Published: April 2019

BackgroundLate-onset preeclampsia (PE) is preeclampsia occurring after 34 weeks of gestational age or later. Cullin 1 (CUL1), a proangiogenic protein, is expressed in the placenta, where an imbalance between proangiogenic and antiangiogenic proteins during gestation can cause disturbance of trophoblast invasion. This defect results in vascular ischemia that may produce preeclampsia. The objective of this study was to determine the correlation between CUL1 as proangiogenic factor and late-onset preeclampsia. MethodsThis study was of analytical observational cross-sectional design and involved 44 preeclampsia patients with ³34 weeks of gestational age (late-onset PE). The CUL1 level in the subjects’ sera, taken before they gave birth, and in homogenates of their placenta, obtained per vaginam or by cesarean section, were examined by the ELISA technique. Statistical analysis was performed with the Spearman correlation test with significant p value of <0.05.ResultsMedian maternal age was 31 years and median gestational age was 37 weeks. Median serum CUL1 was 41.78 pg/mL and median placental homogenate CUL1 was 32.24 pg per milligram of total placental tissue protein. There was no significant correlation between serum CUL1 level and late-onset preeclampsia (r=-0.281; p=0.065). There was also no significant correlation between placental CUL1 level and late-onset preeclampsia (r=-0.166; p=0.281).ConclusionSerum CUL1 and placental CUL1 were not correlated with late-onset preeclampsia. However, this study indicated that low serum CUL1 tends to prolong gestational age in preeclampsia.
Association of human leukocyte antigen-DRB haplotype in multiple sclerosis population of Khuzestan, Iran
Authors: Delfan Nooshin , Galehdari Hamid , Shafiei Mohammad , Ghanbari-Mardasi Farideh , Latifi Tahereh , Majdinasab Nastaran , Seifi Tahereh 
Published: April 2019

Background: One of the demyelinating and inflammatory diseases of the central nervous system (CNS) is multiple sclerosis (MS). Though pathogenesis of MS is still unknown, both genetic and environmental factors are involved. The human leukocyte antigen (HLA) class-II alleles including HLA-DRB5*01, DQB1*0602, DRB1*1501, and DQA1*0102 may have remarkable effect in MS risk although it is controversial in studies. As there is no data with respect to the HLA-DRB1*1501-DRB5*01 correlation with MS in Khuzestan Province, Iran, the goal of the survey was to investigate the association of this haplotype with MS in this population.
Methods: The study focused on DRB5*01-DRB1*1501 haplotype association with MS in 200 patients and 200 healthy individuals. Typing of HLA was carried out by polymerase chain reaction (PCR) amplification with sequence-specific primers (SSP) method. SPSS software was used for the statistical analyses.
Results: No association between DRB5*01+-DRB1*1501+ and MS was found (P = 0.156). Distribution of DRB1*1501+-DRB5*01- (carrying DRB1*1501+ but not DRB5*01-) and DRB1*1501--DRB5*01- haplotypes was statistically different between patients and controls (29.73% vs. 11.81%, P < 0.001) and (42.16% vs. 68.50%, P < 0.001), respectively. However, DRB1*1501--DRB5*01+ revealed no association with MS (15.13% vs. 11.81%, P = 0.403). HLA-DRB1*1501--DRB5*01+ was signiﬁcantly more frequent among female
patients with MS (16.19% vs. 6.12%, P = 0.019) and Persian group (17.11% vs. 5.79%, P = 0.027). Positive correlation of HLA-DRB1*1501+-DRB5*01- haplotype with the expanded disability status scale (EDSS) steps from 5 to 10 was observed (62.50% vs. 25.76%, P = 0.026). Moreover, no meaningful association was shown among the haplotypes with EDSS, course of MS, ethnicity, and gender.
Conclusion: Our findings suggest that DRB1*1501+-DRB5*01- and DRB1*1501--DRB5*01- haplotypes may have positive association with MS risk. Also, this survey indicates that HLA-DRB1*1501--DRB5*01+ is involved in susceptibility of the disease among women and Persians. DRB1*1501+-DRB5*01- genotype frequency may have a key role in MS developing.
Prevalence of dysphagia in multiple sclerosis and its related factors; systematic review and meta-analysis
Authors: Aghaz Alireza , Alidad Alireza , Hemmati Ehsan , Jadidi Hussein , Ghelichi Leila 
Published: April 2019

Background: Dysphagia is the most prevalent sign of multiple sclerosis (MS) which can reduce the quality of life and augment mortality in the final stages of MS. We presented a systematic review to estimate the prevalence of dysphagia in general and separately for each evaluation method (subjective and objective), and to analyze the causes of this rampant disease.
Methods: Cross-sectional and prospective cohort studies were reviewed and scientific
proofs were evaluated consistent with the pre-specified levels of certainty.
Results: Twenty-two articles entered the meta-analysis phase; the estimation of the general prevalence of dysphagia in MS-affected patients was 43.33% related to all the 22 studies. Moreover, the estimate of the prevalence via the subjective (16 studies) and objective (6 studies) methods were 37.21% and 58.47%, respectively.
Conclusion: This study obtained the prevalence rate of dysphagia in patients affected by MS globally, yet there was infinite statistical society and limited methodological quality. Thus, more extensive studies are required for a better understanding of the global epidemiology regarding dysphagia in MS.
Genetic predictors of insulin-producing pancreatic tumor
Authors: Yukina M. Yu. , Nuralieva N. F. , Troshina E. A. 
Published: April 2019

Insulinoma is the most common functioning tumor of the pancreas. Approximately 5% of its cases are associated with the multiple endocrine neoplasia syndrome type 1 (MEN1), caused by mutation in the MEN1 gene. MEN1 can be manifested by pituitary and parathyroid adenomas, pancreatic neuroendocrine tumors, tumors of the thyroid gland, adrenals, intestine, carcinoids of lungs and other organs. However, in 5–10% of the patients with clinical manifestation of this syndrome, MEN1 mutations cannot be identified. Moreover, the disease can be caused by various abnormalities (mutations, polymorphisms, etc.) in other genes. More than 30 genes, associated with insulin-producing pancreatic tumors, have been described in the literature. With a known germinal mutation, the prognosis and management of patients with insulinoma can be determined by the hereditary disease with which the tumor is associated. The article emphasizes the need to search for new genetic markers that predispose to the development of insulinoma. The necessity of extended genetic testing of patients with insulinomas is discussed, primarily of young patients with multifocal lesions, family history and associated disorders.
Incidentally detected adrenal tumors – characteristics of patients and incidence of hormonal disorders
Authors: Grochoła Iga , Winder Mateusz , Kocot Krzysztof , Menżyk Tomasz , Wojnar Jerzy 
Published: April 2019

WstępWraz z gwałtownym postępem technicznym i zwiększoną dostępnością badań obrazowych przypadkowo wykryte guzy nadnerczy stały się częstym problemem endokrynologicznym. Celem pracy była charakterystyka pacjentów
z przypadkowo wykrytymi guzami nadnerczy, ze szczególnym uwzględnieniem wykrywanych nieprawidłowości hormonalnych.Materiał i metodyRetrospektywne jednoośrodkowe badanie objęło 96 pacjentów (21 mężczyzn i 75 kobiet w wieku 28–88 lat, mediana 62 lata), hospitalizowanych w latach 2007–2014 z powodu nowo wykrytych guzów nadnerczy.WynikiGuzy nadnerczy zostały przypadkowo wykryte u 92 pacjentów. Po przeprowadzeniu diagnostyki rozpoznano: gruczolaki nadnercza – incydentaloma – w 73 przypadkach (76%), guzkowy przerost nadnerczy w 12 (12,5%), guzy chromochłonne w 5 (5,2%), późno wykryte wrodzone przerosty nadnerczy w 5 (5,2%) oraz zespół Conna w 1 przypadku (1,1%). Co najmniej jedno zaburzenie hormonalne wykryto u 94 spośród 96 pacjentów. Najczęstszymi zaburzeniami były: nieprawidłowa aktywność reninowa osocza (67,7% pacjentów), nieprawidłowe wieczorne stężenie kortyzolu (60,2%, średnie stężenie: 8,9 µg%) i poranne (48,9%, średnie stężenie: 15,4 µg%). Znaczna grupa pacjentów cierpiała na choroby współistniejące: nadciśnienie tętnicze (70,8%), nieprawidłową tolerancję glukozy (18,7%) i cukrzycę typu 2 (16,7%). Ponadto wykazano odwrotną korelację (p < 0,05) największego wymiaru guza ze stężeniem ACTH.WnioskiU większości pacjentów z przypadkowo wykrytymi guzami nadnerczy, pomimo braku charakterystycznych objawów, można wykryć nieprawidłowości w badaniach hormonalnych. Nadciśnienie i cukrzyca występują u tych pacjentów częściej niż w populacji ogólnej.
Güney Marmara Bölgesi’nde Meydana Gelen Manyas (Mw=4.7) ve Gemlik (Mw=4.8) Depremlerinin Kinematik Analizi
Authors: BEKLER Feyza Nur , ÖZEL Nurcan Meral , TANIRCAN Gülüm 
Published: April 2019

Kuzey Anadolu Fay zonu (KAFz) güney kolunda meydana gelen orta büyüklükte 2 deprem için sismik kaynak karakteri ve faylanmalara ait kaymanın gelişimi incelenmiştir. Bu iki depremden biri 20 Ekim 2006 tarihinde meydana gelen Manyas depremi (Mw=4.7) ve diğeri de 24 Ekim 2006 tarihinde olan Gemlik Körfezi depremi (Mw=4.8) olarak analiz edilmiştir. Her iki depremde, KAFz güney kolundaki son 20 yılda meydana gelen orta büyüklükteki yırtılmalardır. Sayısal analizde kuvvetli yer hareketi (KYH) verisine çoklu zaman-pencereli dalga şekli ters çözümü tekniği uygulanmıştır. Alt fay grupları (tali faylar) ve istasyonlar arasındaki kuramsal Green fonksiyonları bir-boyutlu (1-B) hız yapısı kullanılarak ayrık dalga sayısı yöntemi ile hesaplanmıştır. Bu çalışmada kullanılan ters çözüm tekniği, tekil olmayan çözümü getirmektedir. Bu nedenle hem gözlemsel hem de sentetik veri eşleşene kadar çeşitli yırtılma modelleri denenmiştir. Sonuçlar, kayma dağılımlarında basit modellerine işaret etmektedir. Gemlik ve Manyas depremleri için kayma miktarları sırası ile 0.18m ve 0.12m, sismik moment değerleri ise 3.43E+15 Nm ve 1.73E+15Nm olarak elde edilmiştir. Sonuçlar, küresel ölçekte benzer büyüklükte depremlerle karşılaştırılmış ve sismik moment ile yırtılma arasında yeni bir deneysel ilişki önerilmiştir. Bulguların Güney Marmara bölgesindeki yırtılma mekanizmalarının çözümlenmesinde ve depremlerin tetiklenmesi için yararlı bilgiler sağlamasını amaçlanmıştır.
Resilient urbanization and infrastructure governance: the case of the Phnom Penh Water Supply Authority, 1993–2007
Authors: Spencer James H. , Meng Bunnarith 
Published: April 2019

Abstract
After years of civil war, Cambodia began to focus on reconstruction and the development of its much-needed infrastructure across the country in the early 1990s. While most government institutions at the capital/provincial levels were crippled, the Phnom Penh Water Supply Authority (PPWSA) was able to provide excellent water service to most of the capital's residents, even the extremely poor. This case represents a traditional utility that was able to creatively experiment with new management practices and solicit community involvement in the administration of its work. It also illustrates the fact that under certain conditions, urban water services can actually generate revenues to subsidize other functions of the government. Specifically, it provides a useful illustration of a resilient governance of infrastructure able to adapt to rapidly changing and challenging circumstances.
Costumbre y cosmopolítica náayeri. El dilema del hermetismo y la lucha por el territorio en contra de los megaproyectos
Authors: Benciolini Maria 
Published: April 2019

El objetivo de este trabajo es reflexionar sobre las razones que han llevado a los náayeri a emprender un proceso de resistencia en contra de un proyecto hidroeléctrico en su territorio. El trabajo está dividido en dos partes; en la primera (a través de fuentes de segunda mano) se discute la relación dialéctica entre actividad ritual y vida política de las comunidades náayeri;en la segunda (basada en datos etnográficos) se discute sobre la relevancia de la actual resistencia en contra del proyecto hidroeléctrico debido a la afectación que este causaría en varios sitios sagrados y a la pérdida de ciertas actividades rituales si estos sitios fueran afectados. Entre los resultados, destaca cómo los náayeri, a lo largo de los siglos, han empleado el ritual no solo para establecer relaciones con sus antepasados y dioses, sino también como instrumento político en su relación con los actores políticos y religiosos con quienes han tenido contacto a lo largo de su historia. El texto ofrece una lectura original del costumbre cora y de su eficacia política y ritual tanto con respecto del pasado como de la situación actual. Entre las conclusiones, se determina que las decisiones políticas y las acciones rituales tomadas por las comunidades náayeri frente a la amenaza a sus sitios sagrados pueden ser insertadas en un contexto diacrónico más amplio, en el que las comunidades, a lo largo de los siglos, han construido y negociado sus formas rituales y de acción política para proteger una de las cosas para ellos más importantes: el costumbre.
Dos lecturas de la Epístola moral a Fabio después del exilio de 1939
Authors: Muñoz Covarrubias Pablo 
Published: April 2019

El objetivo principal de este artículo es examinar los vínculos entre la Epístola moral a Fabio, de Andrés Fernández de Andrada, y la obra de los escritores españoles exiliados. Especialmente, este trabajo se acerca a los textos críticos de Luis Cernuda y María Zambrano en los cuales se destaca la relevancia de la tradición poética durante los años iniciales del exilio, y se constata la relevancia que tuvo el gran poema de Fernández de Andrada entre los exiliados. Es de importancia destacar el hecho de que hasta ahora no se había estudiado la recepción de la Epístola en los textos preparados por esta generación de autores.
The Key microRNAs Regulated the Development of Non-small Cell Lung Cancer by Targeting TGF-β-induced epithelial–mesenchymal Transition
Authors: Chen Gang , Ye Bo 
Published: April 2019

Purpose:
Epithelial-to-Mesenchymal Transition (EMT) was reported to play a key role
in the development of Non-Small Cell Lung Cancer (NSCLC). The process of EMT is regulated by
the changes of miRNAs expression. However, it is still unknown which miRNA changed the most
in the process of canceration and whether these changes played a role in tumor development.

Methods:
A total of 36 SCLC patients treated in our hospital between 11th, 2015 and 10th, 2017
were enrolled. The samples of cancer tissues and paracancer tissues of patients were collected and
analyzed. Then, the miRNAs in normal lung cells and NSCLC cells were also analyzed. In the
presence of TGF-β, we transfected the miRNA mimics or inhibitor into NSCLC cells to investigate
the role of the significantly altered miRNAs in cell migration and invasion and in the process of
EMT.

Results:
MiR-330-3p was significantly up-regulated in NSCLC cell lines and tissues and miRNA-
205 was significantly down-regulated in NSCLC cell lines and NSCLC tissues. Transfected
miRNA-205 mimics or miRMA-330-3p inhibitor inhibited the migration and invasion of NCIH1975
cell and restrained TGF-β-induced EMT in NSCLC cells.

Conclusion:
miRNA-330-3p and miRNA-205 changed the most in the process of canceration in
NSCLC. Furthermore, miR-330-3p promoted cell invasion and metastasis in NSCLC probably by
promoting EMT and miR-205 could restrain NSCLC likely by suppressing EMT.
Recent Advances in Apoptosis: THE Role of Hydrazones
Authors: Çıkla-Süzgün Pelin , Küçükgüzel Ş. Güniz 
Published: April 2019

:The process of programmed cell death in higher eukaryotes (apoptosis), is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered as a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Apoptosis seems to play an important key role in the progression of several human diseases like Alzheimer's disease, Parkinson's disease and many types of cancer. Promotion of apoptosis may be a good approach for the prevention of cancer cell proliferation. In early studies, antitumor compounds have been found to induce the apoptotic process in tumor cells. On the other hand, several hydrazones were reported to have lower toxicity than hydrazides due to the blockage of –NH2 group. Therefore, the design of hydrazones that activate and promote apoptosis is an attractive strategy for the discovery and development of potential anticancer agents. The aim of this review is to provide a general overview of current knowledge and the connection between apoptosis and hydrazone. It is also the guide for the apoptotic activities of new hydrazone derivatives.
Manuscripts from Different Brands of Ballpoint Pens – GC/MS Ageing Profile in Brazilian Tropical Weather
Authors: de Carvalho Carina M.B. , Ortiz Scorsatto R. , Limberger Renata P. 
Published: April 2019

Background:
Dating of ballpoint pen manuscripts in forensic documents is still a challenge
for experts. Methods of ink dating consider solvent evaporation through time, especially 2-
phenoxyethanol (2-PE).

Objective:
The objective of the researchers was to perform a continued study with pen ink strokes
of ballpoint pens commercialized in Brazil, to characterize the ageing profile of 15 brands of blue
and black pens.

Methods:
Solvent composition analysis of ballpoint pen ink lines written in white and recycled
paper was performed by gas chromatography/mass spectrometry, to quantify 2-PE, in recently
written lines and in lines aged 4, 18, 27 and 36 months.

Results:
The results showed that the pens had initial quantities of 2-PE smaller than in the Europe
despite of having similar ageing behavior. Such kind of paper had more influence on aged pen
strokes than in the recently applied pen strokes. Light and heat accelerated ageing. Some pens
stopped ageing at 18, 27 and 36 months.

Conclusion:
The results obtained were promising for elucidation of the ageing behavior of pen ink
lines in tropical weather, but further statistical treatments could be done to adequate interpretation
in real cases.
Aspect-Oriented System Coupling Metric and its Validation
Authors: Kaur Amandeep , Grover Pritam Singh , Dixit Ashutosh 
Published: April 2019

Background:Aspect-oriented programming promises to enhance the extensibility and reusability of code through the removal of tangled and crosscutting code. Determining the degree of coupling for Aspect- Oriented Systems (AOSs) would assist in the quantification of various software attributes and hence improve quality.Objective:The research aims to present a novel Aspect-oriented System Coupling Metric (COAO), that calculates the coupling for the complete aspect-oriented system as a whole, based on the properties of elements and the relationships among them.Methods:The process of defining a metric essentially requires a clear, unambiguous definition of primary and relevant concepts related to Aspect-Oriented Programming. As such, first and foremost, novel definitions of basic concepts such as system, element, relation, module, and attribute are specified concerning Aspect- Oriented Programming. Subsequently, a metric for Aspect-Oriented System Coupling is proposed. Subsequently, the proposed metric is validated theoretically against Braiand properties for coupling of software systems. Finally, an illustration for calculation of the proposed metric is demonstrated using an exemplary aspect-oriented system.Results:The findings reveal that the proposed Aspect-Oriented Coupling metric conforms to the five Property- Based software engineering measurements given by Braiand et al. for coupling. This indicates that the proposed metric for the Aspect-oriented System Coupling metric COAO is a valid metric for measuring coupling in Aspect-oriented Software Systems.Conclusion:Results of validation along with the supportive illustration show that single metric to assess coupling for the complete Aspect-oriented Software System is theoretically sound and also easies the calculation of coupling of a software system.
Optimization Based Sink Deployment Technique in WSN to Improve Network Performance
Authors: Chandel Sonal Telang , Sharma Sanjay 
Published: April 2019

Background & Objective:
Currently, WSN (Wireless Sensor Networks) provides a variety
of services in industrial and commercial applications. WSN consists of nodes that are used to sense
the environments like humidity, temperature, pressure, sound, etc. As the use of WSN grows there
are some issues like coverage, fault tolerance, a deployment problem, localization, Quality of Service,
etc. which needs to be resolved. Sink deployment is a very important problem because it is not the only
impact on performance, but also influence on deployment cost. In traditional WSN, a single sink is deployed
in the network, which aggregates all the data. Due to this, the whole network is suffering from
some serious issues like delay, congestion, network failure that reduces network performance.

Methods:
One solution is to deploy multiple sinks instead of a single sink. Deploying multiple sinks
can improve network performance, but increases sink deployment cost. In this paper, an ISDOA (Improved
Sink Deployment Optimization Algorithm) is proposed to find the optimum number of sinks
and their optimum location in ROI. Simulation is carried out in Matlab simulator. The impact of sensors
and sinks on various network performance parameters like throughput, network lifetime, packet
delivery ratio, energy consumption and cost of the network is analyzed.

Results & Conclusion:
It is shown by simulation results that the number of sinks varies inversely
with energy consumption of the nodes; and it is linearly proportional to the network lifetime,
throughput and packet delivery ratio. Furthermore, results show that the proposed approach outperforms
random deployment with 25% higher throughput, 30% better network lifetime, 15% lesser energy
consumption and 21% optimized cost of the network, respectively.