bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histologically Verified Biliary Invasion was Associated with Impaired Liver Recurrence-Free Survival in Resected Colorectal Cancer Liver Metastases
Authors: Reijonen P. , Österlund P. , Isoniemi H. , Arola J. , Nordin A. 
Published: November 2018

Background and Aims: The impact of biliary invasion on recurrence and survival, after resection of colorectal cancer liver metastases, is not well known as publications are limited to small patient series. The aim was to investigate if biliary invasion in liver resected patients associated with liver relapses and recurrence-free survival. Secondary endpoints included association with other prognostic factors, disease-free survival and overall survival. Materials and Methods: All patients with histologically verified biliary invasion (n = 31, 9%) were identified among 344 patients with liver resection between January 2009 and March 2015. Controls (n = 78) were selected from the same time period and matched for, among others, size and number of colorectal cancer liver metastasis. Results: Median liver recurrence-free survival was significantly shorter in patients with biliary invasion than in controls (15.3 months versus not reached; p = 0.031) and more relapses were noted in the liver (61.3% versus 33.3%; p = 0.010), respectively. In univariate analyses for liver recurrence-free survival, biliary invasion was the only significant prognostic factor; p = 0.034. There were no statistical differences in disease-free and overall survival between the groups. Conclusion: Biliary invasion was associated with higher liver recurrence rates and shorter liver recurrence-free survival in patients with resected colorectal cancer liver metastasis.
Plasma cell proliferative index is an independent predictor of progression in smoldering multiple myeloma
Authors: Aljama Mohammed A. , Sidiqi M. Hasib , Lakshman Arjun , Dispenzieri Angela , Jevremovic Dragan , Gertz Morie A. , Lacy Martha Q. , Buadi Francis K. , Dingli David , Muchtar Eli , Fonder Amie L. , Hayman Suzanne R. , Hobbs Miriam A. , Gonsalves Wilson I. , Warsame Rahma , Kourelis Taxiarchis V. , Hwa Yi Lisa , Kapoor Prashant , Leung Nelson , Go Ronald S. , Kyle Robert A. , Rajkumar S. Vincent , Kumar Shaji K. 
Published: November 2018

Abstract
The plasma cell proliferative index (PCPI), determined by a slide technique or by flow cytometry, detects cells in the S phase of the cell cycle and is a useful prognostic tool in patients with plasma cell disorders such as multiple myeloma and amyloidosis. We conducted a retrospective review analyzing the prognostic effect of PCPI in 306 patients with smoldering multiple myeloma (SMM). Seventy-nine (26%) patients had an elevated PCPI (&gt;0.5). An elevated PCPI predicted an inferior time to progression (median, 3.0 vs 7.1 years for those with a low PCPI; P = .0004). Within 24 months, the progression rate was significantly higher for patients with an elevated PCPI (49% vs. 20%; P &lt; .0001). PCPI is a valuable tool in risk stratifying patients with SMM and identifies patients with earlier progression who may benefit from closer follow-up and consideration of early intervention trials.
KIT exon 11 and PDGFRA exon 18 gene mutations in gastric GIST: proposal of a short panel for predicting therapeutic response
Authors: Barcelos Denise , Neto Ricardo Artigiani , Cardili Leonardo , Fernandes Mariana , Carapeto Fernando Cintra Lopes , Comodo Andréia Neves , Funabashi Karina , Iwamura Edna Sadayo Miazato 
Published: November 2018

Abstract
Background
GIST is the most common mesenchymal tumor of gastrointestinal tract and is more frequent in stomach. Its main mutations affect KIT and PDGFRA genes. Full genetic analysis panels are currently used to study mutations in GIST and other tumors. Considering that in gastric GIST KIT gene mutations in exon 11 are sensitive to IM whereas PDGFRΑ gene mutations in exon 18 (D842V) are resistant to the same drug, the aim of this study is to focus on these two molecular targets as a short alternative panel for predicting therapeutic response in gastric GIST which might optimize resources.

Methods
The genotypes of 38 cases of primary GIST were determined by performing bidirectional DNA sequencing.

Results
Exon 11 of KIT gene showed mutations in 65.3% and the exon 18 of PDGFRA gene showed 9% of cases. So it was possible to determine a subgroup of tumors which presented mutations in KIT exon 11 and PDGFRA exon 18.

Conclusion
Considering all of the foregoing analyzed globally, the application of short panel has impact on the cost and time of release of results to the physician, allowing a rapid approach to patients eligible for treatment with the target therapy.
Lack of G1/S control destabilizes the yeast genome via replication stress-induced DSBs and illegitimate recombination
Authors: Krol Kamil , Antoniuk-Majchrzak Justyna , Skoneczny Marek , Sienko Marzena , Jendrysek Justyna , Rumienczyk Izabela , Halas Agnieszka , Kurlandzka Anna , Skoneczna Adrianna 
Published: November 2018

ABSTRACT
The protein Swi6 in Saccharomyces cerevisiae is a cofactor in two complexes that regulate the transcription of the genes controlling the G1/S transition. It also ensures proper oxidative and cell wall stress responses. Previously, we found that Swi6 was crucial for the survival of genotoxic stress. Here, we show that a lack of Swi6 causes replication stress leading to double-strand break (DSB) formation, inefficient DNA repair and DNA content alterations, resulting in high cell mortality. Comparative genome hybridization experiments revealed that there was a random genome rearrangement in swi6Δ cells, whereas in diploid swi6Δ/swi6Δ cells, chromosome V is duplicated. SWI4 and PAB1, which are located on chromosome V and are known multicopy suppressors of swi6Δ phenotypes, partially reverse swi6Δ genome instability when overexpressed. Another gene on chromosome V, RAD51, also supports swi6Δ survival, but at a high cost; Rad51–dependent illegitimate recombination in swi6Δ cells appears to connect DSBs, leading to genome rearrangement and preventing cell death.
This article has an associated First Person interview with the first author of the paper.
Allowing Consumers to Bundle Themselves: The Profitability of Family Plans
Authors: Desai Preyas S. , Purohit Devavrat , Zhou Bo 
Published: November 2018

Telecommunications service is an important and growing market, with worldwide revenue exceeding $2.2 trillion in 2016. In the U.S. market, the total number of mobile wireless connections has grown from 279.6 million in 2008 to 396 million in 2016. All the firms in this market offer consumers an option of purchasing either an individual plan or a family plan. Whereas a menu of individual plans can be thought of as a means to segment the market, the theoretical challenge is to understand how a firm stands to benefit from adding family plans to its product mix. In this paper, we use a game-theoretic framework to explore the role of family plans. Interestingly, we find that even when a family plan does not draw in any new consumers, a firm can still benefit from offering these plans. This occurs primarily because a family plan enables the firm to price discriminate more effectively. In particular, because some consumers can bundle themselves and join a family plan, the firm is able to charge a higher price to single high-valuation consumers who are unable to be part of a family. Furthermore, the presence of a family plan can have a negative impact on the plan offered to single low-valuation consumers who now have to pay a higher overage price. We also show that not all family plans are profitable and that the profitability depends on the sizes of different types of families. The online appendices are available at https://doi.org/mksc.2018.1121 .
ASSESSMENT OF FAST-SPECTRUM BLANKET LATTICES FOR BREEDING FISSILE FUEL FROM THORIUM AND DEPLETED URANIUM IN AN EXTERNALLY DRIVEN SUB-CRITICAL GAS-COOLED PRESSURE TUBE REACTOR
Authors: Bromley Blair Patrick , Alexander Jude 
Published: November 2018

To ensure long-term nuclear energy security, it is advantageous to consider the use of externally driven sub-critical systems for producing fissile fuel to supply fleets of thermal-spectrum reactors as an alternative to using fast-spectrum or thermal-spectrum breeder reactors. Computational/analytical neutronics and heat transfer studies have been carried out for gas-cooled fuel bundle lattices with mixtures of fertile thorium and depleted uranium (DU) that could be used in the blanket region of a sub-critical fast reactor driven either by a fusion reactor in a hybrid fusion-fission reactor (HFFR) system, or an accelerator-based spallation neutron source in an accelerator driven system (ADS). The HFFR or ADS concept envisioned is one with a simple cylindrical geometry. The annular-cylindrical blanket is approximately 10 m long, can be made 2–5 m thick (1.0 m ≤ Rblanket ≤ 3.0 m to 6.0 m), and is filled with a repeating square lattice of pressure tubes filled with 0.5 m long fuel bundles that are made of (DU,Th)O2, with various mixtures of Th and DU, and refuelled periodically online. Although using blankets made of pure DUO2or ThO2are viable options to analyze, mixing DUO2with ThO2can help alleviate any potential proliferation concerns, since any233U produced from breeding will be denatured by the presence of238U in (DU, Th)O2.Lattice calculations demonstrate that the total fissile content in the fuel after an extended period of burnup (50 MWd/kg) will be approximately the same, regardless of the mixture of DU and thorium used, and that the content of americium and232U in the irradiated fuel will be <0.01 wt%/initial heavy metal.
Gonadal shield: Is it the Albatross hanging around the neck of developmental dysplasia of the hip research?
Authors: Kumar A. , Chau W. W. , Hung A. L.-H. , Wong J. K.-T. , Ng B. K. W. , Cheng J. C. Y. 
Published: November 2018

Purpose Prospective randomized controlled trials and long-term studies are essential future directions for building evidence-based practices in developmental dysplasia of the hip (DDH), however, sufficient attrition in data (> 20%) can introduce bias deteriorating research quality. Pelvic radiography is synonymous with DDH assessment and so are Gonadal Shield (GS) recommendations with pelvic radiography. Nonetheless, losses to diagnostic information and inadequate protection have been increasingly implicated to GS usage, with significantly worse implications in female patients. Understandably for DDH, a disease with 80% female prevalence, the impact of GS usage on quality of radiographs and readability of radiological data may be drastic. This study aims to objectively define the implications of GS recommendations in DDH patients. Methods Pelvis radiographs of all DDH patients under the hip surveillance programme at a tertiary care hospital with a written protocol for GS usage were evaluated. Images were reviewed for gender, GS presence, adequate gonadal protection and obstruction of essential anatomical landmarks for pelvic indices. Results In all, 131 pelvis radiographs with DDH diagnoses (age: 1.25 to 6 years; 107 female, 24 male pelvises) were reviewed. Only 42.67% (56) of pelvis radiographs used GS despite the presence of a clear protocol. Useful anatomical landmarks were obstructed in 58.9% of radiographs with GS present. Lost diagnostic information was more common in female patients than male patients (68.1% versus 11.1%, p < 0.01). GS was ineffective at gonadal protection in 73.2% (41) of the pelvises with worse protection in female patients (78.7% vs 44.4%; p = 0.03). Conclusions Ironically, essential anatomy was obstructed in all the adequately protected female pelvises. Routine GS usage results in substantial attrition of radiographic data in DDH patients. Level of Evidence III
Two approaches to socially engaged art with the Hong Kong Filipino community
Authors: Vigneron Frank 
Published: November 2018

Abstract
The Filipino community of Hong Kong has often suffered from the way the vast majority of its members are perceived: their work as domestic helpers has created conditions for the general Hong Kong public to put them in a subservient position within the local society. Local art practitioners have recently attempted to address this issue by creating art projects aimed at changing the position of Filipino domestic workers in the social culture of the SAR. Zheng Bo created an interactive object in a public space that he himself presents as a public service, while Luke Ching (working for within the Rooftop Institute collective) organized a number of workshops aimed at bringing together the Filipino domestic helpers and the children of the family who employ them. While both approaches are designed to bring people from widely different horizons together to work out and reconcile their differences, they, however, function very differently and fulfil profoundly different missions. These two projects will be analysed and assessed in the context of the ideas of Nicolas Mirzoeff about visual culture and the frequently quoted works of Jacques Rancière in the domain of socially engaged art practices.
Faces from the detention camps – revisiting Art In the Camps (1988–91)
Authors: Yin Leung Ho 
Published: November 2018

Abstract
‘Refugee’ and ‘socially engaged’ are two of the very popular terms being discussed in the recent art world. This article aims to discuss the two keywords relating to the notion of ‘art outside art space’ by using a very early example in Hong Kong, Art In the Camps (AIC) (1989–91). A decade before pedagogy became a popular form to engage with people, a group of artists in Hong Kong organized a project that took place right inside the detention camp for Vietnamese refugees. This project demonstrates two layers of significance: first, it reveals a very early attempt to engage with refugees through different artistic strategies in the late 1980s; second, it shows how art could function beyond art space (in this case, art is put in the detention camp). This article will look at AIC with Foucault’s spatial theory of ‘heterotopias’. Although Foucault did not discuss the dimension of race/ethnic problems, this article would still like to borrow his understanding on the problems of classification of space through the metaphor of a mirror to interpret AIC as an early example of socially engaged art in Hong Kong. The article will be developed into two parts. First, the media representation of Vietnamese refugee in Hong Kong through newspapers published at that time. This part will also touch on how the Detention Camps, in which the British government settled Vietnamese refugees in Hong Kong, were illustrated as a space of deviation and crisis. Following images that represent the detention camps as pseudo-prisons, the second part will zoom-in at what AIC actually did inside the detention camps.
The development of fly ash – red mud based geopolymer
Authors: Ambrus Mária , Mucsi Gábor , Szabó Roland , Kovács Balázs 
Published: November 2018

Taking into account environmental considerations, such as decreasing CO2 emission and the ecological footprint, the utilisation of secondary raw materials is essential for sustainable development. Fly ash is the product of coal combustion plants that is collected by various air cleaning equipment from flue gas, and red mud is the by-product of the Bayer-process, through which alumina can be produced from bauxite. Geopolymerisation is a process that is suitable for the utilisation of such wastes to produce ceramics, cement, concrete etc. with many advantageous properties.
The main objective of the article is to present data on the development and examination of geopolymer made out of deposited fly ash from Tatabánya and red mud from Almásfüzitő.
During the experiments, red mud was added to previously optimised fly ash geopolymer in various quantities and compressive strength tests were carried out to determine the optimal fly ash and red mud ratio. However, as the cracking of the specimens could be observed, further tests were carried out on the durability of the geopolymers. The effect of the sealing conditions and RM calcination was investigated, both via visual inspection and with FT-IR analysis at the ages of 3, 7, 14, 28 and 90 days.
Based on the results, it could be concluded that the sealing conditions have direct effect on the structural characteristics of fly ash – red mud based geopolymers, but further experiments should be carried out for the identification of the ongoing reactions.
Education in the public space: the civic pedagogy of the Minas Gerais newspapers in the regency period / A educação no espaço público: a pedagogia cívica dos jornais mineiros no período regencial
Authors: Gomes Marcilaine Soares Inácio , Faria Filho Luciano Mendes de , Mesquita Ilka Miglio de 
Published: November 2018

O artigo tem por objetivo evidenciar, a partir de jornais, o uso do espaço público pelas associações mineiras do período regencial na configuração de um plano de educação, tendo em vista a pedagogia cívica de disciplinar, instruir, civilizar e moralizar. Seus projetos educativos são entendidos como projetos políticos-culturais, definidos na relação com dois fenômenos que estão entrelaçados e são complementares, contudo, distintos: a difusão das Luzes e a configuração de uma esfera pública de poder.Palavras-chave: Associações Mineiras, Jornais, Período Regencial. AbstractThe purpose of this article is to show, from newspapers, the use of public space by the associations in Minas Gerais, during the regency period, in the configuration of an education plan, in view of the civic pedagogy of disciplining, educating, civilizing and moralizing. Its educational projects are understood as political-cultural projects, defined in relation to two phenomena that are intertwined and complementary, yet distinct: the diffusion of the Lights and the configuration of a public sphere of power.Keywords: Associations in Minas Gerais; Newspapers; Regency Period. ResumenEl artículo tiene como objetivo evidenciar, desde los periódicos, la utilización del espacio público por las asociaciones mineiras del período de la regencia brasileña em la configuración de um plan de educación, teniendo em vista la pedagogía cívica de disciplinar, instruir, civilizar y moralizar. Sus proyectos educativos serán comprendidos como proyectos políticos-culturales, definidos em la relación de dos fenómenos que están entrelazados y son complementários, sin embargo distintos: la difusión de las luces y la configuración de uma esfera pública de poder.Palabras claves: Asociaciones Mineiras; Periódicos; Período de la Regencia de Brasil
The Spanish Language and Military Education in Brazil (1905-1920) / A Língua Espanhola e a Educação Militar no Brasil (1905-1920) / La Lengua Española y la Educación Militar en Brasil (1905-1920)
Authors: Guimarães Anselmo , Souza Josefa Eliana 
Published: November 2018

Este estudo é o resultado da investigação do processo de institucionalização do ensino de espanhol na educação militar brasileira, de 1905 a 1920, buscando delinear as finalidades políticas e culturais. O objetivo foi investigar as justificativas para a entrada do espanhol no ensino militar, no período de 1905, quando o idioma foi inserido oficialmente no currículo militar, mediante Decreto nº 5.698 e, finalizou em 1920, após reformularem os regulamentos militares e o ensino de espanhol deixar de ser oferecido no âmbito militar. Para tanto, foram utilizados a legislação educacional e textos jornalísticos, bem como pressupostos teóricos da história das disciplinas escolares.Palavras-chave: Educação Militar; História do Ensino de Espanhol; História das Disciplinas Escolares. AbstractThis study is the result of the investigation of the process of institutionalization of the Spanish language teaching at the Brazilian military education, from 1905 to 1920, aiming at outlining political and cultural purposes. The goal has been to investigate the justifications for the insertion of the Spanish language in the Brazilian military education, starting in 1905, when the language has been officially inserted in the military curriculum under Decree No. 5.698 and ending in 1920, after the redesign of the military regulations and the fact that the Spanish language teaching has no longer been offered in the military scope. For this purpose, educational legislation and journalistic texts have been used, as well as theoretical assumptions of the history of school subjects. Keywords: Military Education; The History of the Spanish Language Teaching; The History of School Subjects. ResumenEste estudio es el resultado de la investigación del proceso de institucionalización de la enseñanza de español en la educación militar brasileña, de 1905 a 1920, buscando delinear las finalidades políticas y culturales. El objetivo fue investigar las razones de la entrada del español en la enseñanza militar, en el período de 1905, cuando el idioma fue introducido oficialmente en el plan de estudios militares por el Decreto nº 5.698 y terminado en 1920, después de reformularen los reglamentos militares y la enseñanza del español salió del ámbito militar. Por lo tanto, hemos utilizado la legislación educativa y textos periodísticos, así como supuestos teóricos de la historia de las disciplinas escolares.Palabras clave: Educación Militar; Historia de la Enseñanza del Español; Historia de las Disciplinas Escolares.
Measurement of earnings management before and after applying IFRSS using jones' modified method an applied research in a sample of banks listed in the Iraqi stock exchange
Authors: Sabeha Barzan Farhood Dr 
Published: November 2018

In the year 2016, all commercial banks in Iraq were obliged to switch from the application of the local unified accounting system to the application of International Financial Reporting Standards (IFRSs) to improve the quality of accounting information and make it relevant for decision-making. The objective of the research is to measure earnings management in a number of banks which applied IFRSs at the end of the financial year 2016 through their application on a sample of banks for the years (2012-2013, 2014, 2015, 2016). The results were compared with the measurement of earnings management under the application of the unified accounting system (before the adoption of IFRSs) and after the application of the (IFRSs). The researcher concluded that the percentage of earnings management in the years in which the banks applied the unified accounting system is very close to its percentage in the case of the application of IFRSs, which shows that the application of IFRSs did not change the percentage of earnings management in banks.Â Â
Coping skill training and family health education against anxiety in prevention substance abuse in Indonesia
Authors: Sukamti Nita , Anna Keliat Budi , . Mustikasari 
Published: November 2018

Adolescents are vulnerable to get anxiety and it can affect to substance use. Coping skill training and family health education are mental nursing intervention that is expected to overcome anxiety. The goals of the research to determine the influence of coping skill training and family health education against anxiety in Junior High School. The research design is quasi-experimental pre-posttest with control group and 87 students in Junior High School was chosen by using purposive sampling technique then continued with cluster random sampling. Respondents were divided into 2 groups. Group 1 get nursing intervention and group 2 get nursing intervention, coping skills training, and family health education. The results showed decrease of anxiety that not significant after nursing intervention (p value > 0.05), and significantly decrease of anxiety after the coping skill training and family health education (p value < 0,05). Coping skill training and family health education is recommended to decrease anxiety in adolescent.Â Â