bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased nuclear factor I/B expression in prostate cancer correlates with AR expression
Authors: Nanda Jagpreet S. , Awadallah Wisam N. , Kohrt Sarah E. , Popovics Petra , Cates Justin M. M. , Mirosevich Janni , Clark Peter E. , Giannico Giovanna A. , Grabowska Magdalena M. 
Published: June 2019

AbstractBackgroundMost prostate cancers express androgen receptor (AR), and our previous studies have focused on identifying transcription factors that modify AR function. We have shown that nuclear factor I/B (NFIB) regulates AR activity in androgen-dependent prostate cancer cellsin vitro. However, the status of NFIB in prostate cancer was unknown.MethodsWe immunostained a tissue microarray including normal, hyperplastic, prostatic intraepithelial neoplasia, primary prostatic adenocarcinoma, and castration-resistant prostate cancer tissue samples for NFIB, AR, and synaptophysin, a marker of neuroendocrine differentiation. We interrogated publically available data sets in cBioPortal to correlateNFIBexpression and AR and neuroendocrine prostate cancer (NEPCa) activity scores. We analyzed prostate cancer cell lines for NFIB expression via Western blotting and used nuclear and cytoplasmic fractionation to assess where NFIB is localized. We performed coimmunoprecipitation studies to determine if NFIB and AR interact.ResultsNFIB increased in the nucleus and cytoplasm of prostate cancer samples versus matched normal controls, independent of Gleason score. Similarly, cytoplasmic AR and synaptophysin increased in primary prostate cancer. We observed strong NFIB staining in primary small cell prostate cancer. The ratio of cytoplasmic-to-nuclear NFIB staining was predictive of earlier biochemical recurrence in prostate cancer, once adjusted for tumor margin status. Cytoplasmic AR was an independent predictor of biochemical recurrence. There was no statistically significant difference between NFIB and synaptophysin expression in primary and castration-resistant prostate cancer, but cytoplasmic AR expression was increased in castrationresistant samples. In primary prostate cancer, nuclear NFIB expression correlated with cytoplasmic NFIB and nuclear AR, while cytoplasmic NFIB correlated with synaptophysin, and nuclear and cytoplasmic AR. In castration-resistant prostate cancer samples,NFIBexpression correlated positively with an AR activity score, and negatively with the NEPCa score. In prostate cancer cell lines, NFIB exists in several isoforms. We observed NFIB predominantly in the nuclear fraction of prostate cancer cells with increased cytoplasmic expression seen in castration-resistant cell lines. We observed an interaction between AR and NFIB through coimmunoprecipitation experiments.ConclusionWe have described the expression pattern of NFIB in primary and castrationresistant prostate cancer and its positive correlation with AR. We have also demonstrated AR interacts with NFIB.
ShadowCaster: compositional methods under the shadow of phylogenetic models for the detection of horizontal gene transfer events in prokaryotes
Authors: Sánchez-Soto Daniela , Agüero-Chapin Guillermin , Armijos-Jaramillo Vinicio , Perez-Castillo Yunierkis , Tejera Eduardo , Antunes Agostinho , Sánchez-Rodríguez Aminael 
Published: June 2019

AbstractHorizontal gene transfer (HGT) plays an important role in the evolution of many organisms, especially in prokaryotes where commonly occurs. Microbial communities can improve survival due to the evolutionary innovations induced by HGT events. Thus, several computational approaches have arisen to identify such events in recipient genomes. However, this has been proven to be a complex task due to the generation of a great number of false positives and the prediction disagreement among the existing methods. Phylogenetic reconstruction methods turned out to be the most reliable but they are not extensible to all genes/species and are computationally demanding when dealing with large datasets. On the other hand, the so-called surrogate methods that use heuristic solutions either based on nucleotide composition patterns or phyletic distribution of BLAST hits can be applied easily to genomic scale, however, they fail in identifying common HGT events. Here, we present ShadowCaster, a hybrid approach that sequentially combines compositional features under the shadow of phylogenetic models independent of tree reconstruction to improve the detection of HTG events in prokaryotes. ShadowCaster predicted successfully close and distant HTG events in both artificial and bacterial genomes. It detected HGT related to heavy metal resistance in the genome of Rhodanobacter denitrificans with higher accuracy than the most popular state-of-the-art computational approaches. ShadowCaster’s predictions showed the highest agreement among those obtained with other assayed methods. ShadowCaster is released as an open-source software under the GPLv3 license. Source code is hosted at https://github.com/dani2s/ShadowCaster and documentation at https://shadowcaster.readthedocs.io/en/latest/.
A non-canonical unfolded protein response pathway and mitochondrial dynamics control the number of ER-mitochondria contact sites
Authors: Kojima Rieko , Kakimoto Yuriko , Shinmyo Manatsu , Kurokawa Kazuo , Nakano Akihiko , Endo Toshiya , Tamura Yasushi 
Published: June 2019

AbstractMitochondria maintain their morphology and functions through the optimized balance between the mitochondrial fusion and division. Here we report a novel role of mitochondrial dynamics in controlling the number of ER-mitochondria encounter structure (ERMES) clusters in a yeast cell. Loss of mitochondrial fusion or division caused the increased or decreased number, respectively, of ERMES foci observed in cells. ERMES complexes, therefore, appear to cluster with each other and mitochondrial division may inhibit undesired ERMES hyper-clustering. Furthermore, our microscopic analyses suggest that ER stress induces dissociation of ERMES clusters, increasing the number of ERMES foci even in the absence of Ire1 and Hac1, which are essential factors for the UPR response. Interestingly, we found that ER stress leads to expansion of both the ER and mitochondrial membranes in an ERMES function-dependent manner. These findings imply that a cell is equipped with two independent regulatory mechanisms controlling the number of ER-mitochondria contact sites to meet the cellular as well as environmental demands.
An MBD based framework for relative position accuracy measurement in digital assembly of large-scale component
Authors: Duan Guijiang , Shen Zhibang , Liu Rui 
Published: June 2019

Purpose
This paper aims to promote the integration of the relative position accuracy (RPA) measurement and evaluation in digital assembly process by adopting the model-based method. An integrated framework for RPA measurement is proposed based on a model-based definition (MBD) data set. The study also aims to promote the efficiency of inspection planning of RPA measurement by improving the reusability and configurability of the inspection planning.

Design/methodology/approach
The works have been carried out on three layers. In the data layer, an extended MBD data set is constructed to describe the objects and data for defining RPA measurement items; In definition layer, a model based and hierarchical structure for RPA item definition is constructed to support quick definition for RPA measurement items. In function layer, a toolset consisting three modules is constructed in a sequence from measurement planning to RPA value solving to visualized displaying again. Based on this framework, a prototype system is developed.

Findings
The paper provides an identified practice of model-based inspection. It suggests that MBD is valuable in promoting both the integration and efficiency of digital inspection.

Research limitations/implications
The templates and constructed geometry objects given in this paper are still limited in a scenario of aircraft assembly. The integrity and universality of them still need follow-up works.

Practical implications
The paper includes implications for the model based digital inspection, the digital assembly and the extended application of MBD.

Originality/value
This paper expands the application of MBD in inspection and fulfils the need to promote the integration and efficiency of digital inspection in large-scale component assembly.
Measurement scale of international opportunity identification in early internationalization firms
Authors: Mostafiz Md Imtiaz , Sambasivan Murali , Goh See Kwong 
Published: June 2019

PurposeThe purpose of this paper is to develop the international opportunity identification (IOI) scale through psychometric evaluation in an emerging economy context.Design/methodology/approachSamples consist of international firms operating in the apparel industry in Bangladesh. Exploratory factor analysis (EFA) was conducted on the first wave of responses to unfold the underlying dimensions of IOI. The second wave of data was used to confirm the validity of IOI scale through confirmatory factor analysis (CFA).FindingsEFA suggests a unidimensional scale, which is supported by CFA. The relationship between IOI and financial performance is significant and confirms nomological validity. Results also confirm the validity and reliability of the IOI scale.Originality/valueThis study indicates that IOI is a reliable and valid scale to measure the strategic action of the international firms operating in emerging economies, and has a positive relationship with financial performance.
Evolution of corporate governance in India and its impact on the growth of the financial market: an empirical analysis (1995-2014)
Authors: Guha Shouvik Kumar , Samanta Navajyoti , Majumdar Abhik , Singh Mandeep , Bharadwaj Ananya 
Published: June 2019

PurposeThe past few decades have seen a gradual convergence in corporate governance norms the world over, entailing a discernible shift towards shareholder primacy models. It holds particularly true of developing countries, many of which have steadily amended corporate governance norms to enhance the scope of shareholder rights. This is usually justified through the rationale that increasing protection for foreign investors and shareholders would mean greater investment in capital market and overall financial market development. In India, the shift coincides with a series of fundamental economic and financial policy reforms initiated in the 1990s: collectively and loosely referred to as “liberalisation”, this process marks a paradigm-shift from a tightly controlled welfare economy to one considerably more laissez-faire in its orientation. A fallout of which was that the need to attract and sustain foreign investments acquired an unprecedented significance. The purpose of this paper is to help the readers understand in this larger context the corporate law reform initiatives in India, particularly those pertaining to shareholder rights and allied issues.Design/methodology/approachThis paper empirically tests the hypothesis that enhanced shareholder protection leads to greater levels of investments, and financial developments generally. It then uses regression analysis to detect if the change in corporate governance, making it more shareholder-friendly, has had any effect on growth in financial market. It is divided into two broad parts. The first tracks the evolution of corporate governance norms in India. A robust qualitative and quantitative analysis is used to determine the tilt towards a shareholder primacy regime that Indian corporate governance regime now displays. The second chapter deals with the regression analysis where the outcome variable is financial market growth, and explanatory variable is the change in the governance regime with relevant control variables.FindingsThe authors find that change in shareholder primacy corporate governance has little effect on financial market growth in India. The authors would suggest that instead of changing the law in books, more emphasis should be given to implement those regulations and increase the overall rule of law.Originality/valueThis is the first time that such a wide-scale study has been conducted in India, using Bayesian methods. It ought to be of immense value to professionals and academics both.
Finding “just right” books for children: analyzing sentiments in online book reviews
Authors: Choi Yunseon 
Published: June 2019

Purpose
This study is part of a larger research project which aims to investigate whether sentiments in online reviews on children’s books would represent significant factors which are useful for selecting the right books for children. This paper aims to examine whether positive, negative or neutral attitude would be directly associated with the overall ratings of books.

Design/methodology/approach
The study investigates subjectivity and polarity of online reviews on children’s books such as neutral, positive or negative sentiment. For the investigation of a statistical association between the sentiment values and the rating scores, this study performs correlation analysis. For a clear explanation of the factors affecting the relationships between the sentiment value and the rating score, this study uses the concept-level sentiment analysis of online reviews.

Findings
The findings of this study demonstrate that there is a weak or low correlation between the sentiment value and the rating score of a book and they are hardly related for most books. The results of this study also uncover key contributing factors that affected the correlations between two variables and made the relationship weak.

Research limitations/implications
This study increases awareness of the implications of online reviews as user-generated contents for complementing the existing controlled vocabulary.

Practical implications
This study contributes to improving library catalogs by using latent topics extracted from online reviews which provide additional access points for assisting in the selection of books.

Originality/value
Although several studies have conducted on online reviews in the domain of business, no research appears to exist on the sentiment analysis of online reviews about children’s books. This study attempts to address the potential and challenges associated with using online reviews to help find the right books for children.
Can green taxation trigger plug-in hybrid electric vehicle acquisition?
Authors: Barros Victor , Pádua Hugo 
Published: June 2019

Purpose
The purpose of this paper is to analyse to what extent financial incentives under the green tax reform introduced in Portugal in 2014 drive behaviours of acquiring a plug-in hybrid electric vehicle (PHEV).

Design/methodology/approach
The existent literature identifies a number of factors that influence the interest for PHEV acquisition, including access to financial incentives. However, empirical evidence is not clear as to which factors are more relevant. The authors extend an existent theoretical model of five factors by including ten factors. On this basis, the study carries out a survey and develops a structural equation model to investigate what drives the interest to acquire a PHEV.

Findings
Financial incentives are superior to other factors in explaining the interest in acquiring a PHEV. Education, lower income levels, living in larger cities and driving smaller vehicles shape the interest on these vehicles differently. Financial incentives were found to closely offset the difference in price between conventional vehicles and plug-in hybrids.

Social implications
This study finds that public policies can be powerful in shaping consumers’ behaviour, although the amount of the financial incentive is key to triggering a large-scale effect.

Originality/value
The survey in this study allows an in-depth and ex ante analysis of the interest in acquiring PHEV under a green tax reform, taking into account other dimensions and socio-economic variables not accounted for in existent studies.
Willingness to pay for airline security
Authors: Shahrabani Shosh , Teitler Regev Sharon 
Published: June 2019

Purpose
Due to recent international media reports of terrorist attacks in airports, people are more aware of the risk terrorism poses to flying and the need for security measures in the airline industry. This study aims to examine factors affecting willingness to pay (WTP) for airline security and safety flights after terror attacks incident.

Design/methodology/approach
A polling company distributed an internet survey among 415 Israelis in July 2014, after thousands of missiles had been fired into Israel from the Gaza Strip, threatening the population and disrupting aviation traffic to and from Israel. The results show that individuals who attributed higher importance to airline security and exhibited more fear and less optimism were willing to pay more for airline security and safety.

Findings
The results show that individuals who attributed higher perceived importance to airline security and exhibited more fear and less optimism were willing to pay more for the security and safety of flying.

Research limitations/implications
The implications of the study are important for understanding how terrorist attacks and negative aviation events affect people’s feelings, pessimism/optimism and general attitudes toward airline security.

Originality/value
Due to the increase in the number of terror attack involving airlines, it is important for understanding the demand for tickets on secure airlines. Such an understanding is essential for evaluating the perceived benefit of safety and security improvements in the aviation industry and for developing marketing strategies for different tickets.
Emerging structural models for governance of public hospitals
Authors: Lipunga Andrew Munthopa , Tchereni Betchani M.H. , Bakuwa Rhoda Cythia 
Published: June 2019

Purpose
The purpose of this paper is to present the contemporary understanding and emerging structural models of organisational governance of public hospitals in order to provide evidence-based guidance to countries that are reforming their public hospital governance structures in line with best practice.

Design/methodology/approach
The paper uses the structural dimension of Cooper, Fusarelli and Randall’s policy model and institutional theory to review the legislative frameworks of four model countries supported by extant literature.

Findings
The paper conceptually distinguishes health system governance and organisational governance in the health system. It further visualises the emerging alternative legislative models of organisational governance and a hierarchy of governors applicable to public hospitals.

Originality/value
The paper provides critical knowledge for understanding organisational governance within health system governance framework and develops tools that can be used in reforming institutional mechanism of organisational governance of public hospitals.
Rainwater propeller pumps structural integrity
Authors: Galatanu Sergiu Valentin , Muntean Sebastian , Marsavina Liviu , Ailinei Iulian Ionut , Micota Dan 
Published: June 2019

Purpose
The purpose of this paper is to focus on the structural integrity of the rainwater propeller pumps installed in the municipal wastewater treatment plant (WTP).

Design/methodology/approach
A numerical analysis is performed to determine the maximum shear stress on the fasten bolts. The rainwater propeller pump is examined in operation at normal conditions and when one blade is progressively blocked.

Findings
The failure mechanism of the rainwater pump impeller is determined.

Research limitations/implications
The fibbers and wastes are discharged together with rainwater during storms with these types of pumps to avoid the flood of the WTP. Several catastrophic events have occurred in service due to the fibbers clog the gap between the impeller blades and the pump casing. The clogging process is partially understood so actual technical solutions deal with effects rather the main causes.

Practical implications
The operation time of all seven rainwater pumps installed in Timisoara’s WTP is investigated. Climate changes in Banat region and new waste properties found in the wastewater require appropriate technical solutions. A technical solution is proposed based on these investigations to extend the operation time and to diminish the operation and maintenance costs.

Social implications
These large pumps are installed in the urban sewage centralised system implemented in the most cities. The access to the sewerage network is a requirement of any community, regardless of the social status.

Originality/value
The fracture surfaces of both fastening bolts of the rainwater pump impellers produced in service are examined. As a result, it has been identified that the catastrophic events are due to the brittle fracture of both fasten bolts between the impeller blades and the pump hub, respectively. The catastrophic events of the rainwater propeller pumps are directly correlated to the clog level of the impeller. The numerical simulation is performed to determine the maximum shear stress on the fasten bolts. The case with pump operating at normal conditions is performed identifying its vulnerabilities to clog conditions. Next, one impeller blade is progressively blocked considering three time stop scenarios associated with different clog levels. Conclusively, the operating time of the rainwater pump up to the catastrophic failure is correlated to the clog level of the impeller.
Human factors in information leakage: mitigation strategies for information sharing integrity
Authors: Wong Wai Peng , Tan Hwee Chin , Tan Kim Hua , Tseng Ming-Lang 
Published: June 2019

PurposeThe purpose of this paper is to explore the human factors triggering information leakage and investigate how companies mitigate insider threat for information sharing integrity.Design/methodology/approachThe methodology employed is multiple case studies approach with in-depth interviews with five multinational enterprises (MNEs)/multinational corporations (MNCs).FindingsThe findings reveal that information leakage can be approached with human governance mechanism such as organizational ethical climate and information security culture. Besides, higher frequency of leakages negatively affects information sharing integrity. Moreover, this paper also contributes to a research framework which could be a guide to overcome information leakage issue in information sharing.Research limitations/implicationsThe current study involved MNCs/MNEs operating in Malaysia, while companies in other countries may have different ethical climate and information sharing culture. Thus, for future research, it will be good to replicate the study in a larger geographic region to verify the findings and insights of this research.Practical implicationsThis research contributes to the industry and business that are striving toward solving the mounting problem of information leakage by raising awareness of human factors and to take appropriate mitigating governance strategies to pre-empt information leakage. This paper also contributes to a novel theoretical model that characterizes the iniquities of humans in sharing information, and suggests measures which could be a guide to avert disruptive leakages.Originality/valueThis paper is likely an unprecedented research in molding human governance in the domain of information sharing and its Achilles’ heel which is information leakage.