bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population
Authors: Zhao Lei , Fang Jinghuan , Zhou Muke , Zhou Jie , Yu Lihua , Chen Ning , He Li 
Published: July 2019

Abstract
Background

Mutations of cyclooxygenase gene (COX gene) may increase the susceptibility of ischemic stroke. We investigated five variants (rs5788, rs1330344, rs3842788, rs20417, and rs689466) of two COX genes to explain the association between these polymorphisms and ischemic stroke risk determine whether gene–gene interaction between these genes increase the susceptibility of ischemic stroke or its subtypes.

Methods

A total of 1981 study subjects (1078 cases and 903 control subjects) were recruited. The interaction of multiple factors was investigated using Multifactor Dimensionality Reduction and additive effect of single nucleotide polymorphisms on ischemic stroke or its subtypes were analyzed by multiple factor logistic regression.

Results

At COX-1(rs1330344), AA genotype carriers had a lower susceptibility of ischemic stroke (OR=0.657, 95%CI= 0.437-0.988, P = 0.044), and A allele carriers had a lower susceptibility of ischemic stroke (OR=0.812, 95%CI= 0.657-0.978, P = 0.029). At COX-1(rs3842788), AA genotype carriers had a higher susceptibility of ischemic stroke (OR =5.203, 95% CI=1.519-5.159, P =0.016). At COX-2 (rs689466), AA genotype carriers had a higher susceptibility of large-artery atherosclerosis (OR =1.404, 95% CI=1.019-1.934, P =0.038). COX-1(rs1330344, rs3842788) and COX-2 rs689466 interacted in SVO, but had no additive effect with ischemic stroke or its subtypes.

Conclusions

At rs1330344, AA genotype may reduce the susceptibility of ischemic stroke. At rs3842788, AA genotype may increase the susceptibility of ischemic stroke. At rs689466, AA genotype may increase the susceptibility of large-artery atherosclerosis (LAA). COX-1(rs1330344, rs3842788) and COX-2 rs689466 interacted in small vessel occlusion (SVO), but had no additive effect with ischemic stroke or its subtypes.
Changing face of Candida colonization pattern in pediatric patients with hematological malignancy during repeated hospitalizations, results of a prospective observational study (2016-2017) in Shiraz, Iran
Authors: Hamzavi Sedigheh , Amanati Ali , Badiee Parisa , Kadivar Mohammad Rahim , Jafarian Hadis , Ghasemi Fatemeh , Haghpanah Sezaneh , Dehghani Mansooreh , Baghani Abbas Norouzian 
Published: July 2019

Abstract
Background: Surveillance of current changes in the epidemiology of Invasive Fungal Diseases (IFDs) as an important component of the antifungal stewardship programs (ASP), requires careful regular monitoring, especially in high-risk settings such as oncology centers. This study aimed to examine Candida colonization status and corresponding current changes in children with malignancy during repeated admissions and also investigate the possible epidemiological shifts after the implementation of ASP.

Methods: In this prospective observational study, all eligible patients younger than 18 years were recruited during 2016-2017 at Amir Medical Oncology Center (AMOC) in Shiraz, Iran. Totally, 136 patients were enrolled and 482 samples were collected from different sites (oral/nasal discharges, urine and stool). Weekly regular sampling was carried out during hospitalization. Candida colonization status and epidemiological changes were monitored during repeated admissions. Samples were cultivated on Sabouraud Dextrose agar medium and identified by Polymerase Chain Reaction -Restriction Fragment Length Polymorphism (PCR-RFLP).

Results: Estimated Candida colonization incidence was 59.9% (82/136) in our patients. Candida colonization was found to be higher in oral cavity and rectum than that in nasal cavity. Among those long-term follow ups and repetitive hospitalizations, a significant number of patients exhibited changes in their colonization patterns (37.7%). Candida colonization did not reveal any significant relationship with age, sex, oncologic diseases and degree of neutropenia. C. albicans (72.0%) was found as the most common Candida species in colonized patients, followed by C. krusei, C. kefyr, C. glabrata and C. parapsilosis.

Conclusion: Given the high incidence of Candida infections in children with cancers, close monitoring of epidemiologic changes is essential for judicious management, based on local surveillance data and improvement of overall quality of care in high risk patients.

Key Words: Candida Albicans, Fungal Colonization, Pediatric Leukemia
Peripheral T cell lymphoma after chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A case report
Authors: Liu Xiao-hang , Jin Fan , Zhang Meng , Liu Mei-xi , Wang Tao , Pan Bo-ju , Zhang Lu 
Published: July 2019

Abstract
Background

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an inflammatory disorder in the central nervous system (CNS) with distinct clinical, radiological, and pathological characteristics. The pathophysiology of CLIPPERS still remains unclear. Because a few cases about lymphoma mimicking the manifestations of CLIPPERS were reported and the prognosis of lymphoma is much worse, early identification of lymphoma is very important.

Case presentation

A 31-year-old woman was admitted with 3 months’ history of diplopia, dizziness, gait ataxia and right facial numbness. The diagnosis of CLIPPERS was established based on the finding of punctate enhancing lesions in the cerebellum, thalamus, pons, medulla, and midbrain region in magnetic resonance imaging (MRI), together with the favorable clinical and radiological responses to corticosteroids. However, she was diagnosed as peripheral T cell lymphoma, not otherwise specified (PTCL-NOS) by the pulmonary nodular and the skin biopsy almost 10 years later, and she got complete remission within 1 year after chemotherapy.

Conclusion

We report the first case of CLIPPERS developing PTCL-NOS. This case proposes that when brain biopsy was difficult to achieve, biopsies in extra-cerebral lesions under the assisting examination of positron emission tomography-computed tomography (PET-CT) can be helpful in further identification.
Psychological Capital and Business Success of Chinese, Minangnese, and Javanese Entrepreneurs
Authors: Andri Nofri , Ronauli Puji Tania , Riyanti Benedicta P. Dwi 
Published: July 2019

Psychological capital (Psycap) is a condition of positive psychology (hope, efficacy, resilience, and optimism), which facilitates entrepreneurs to survive in running and reach success in their business. This research was intended to obtain the overviews of psycap and business success of Chinese, Minangnese, and Javanese entrepreneurs. There was a total of 207 entrepreneurs involved as respondents. There were two instruments used in this study: the Psychological Capital Scale and the Balanced Scorecard. Data analysis method applied to measure psychological capital was a descriptive statistic. The result showed that Javanese entrepreneurs had a very high level of psychological capital, while both Chinese and Minangnese entrepreneurs hold on the same high degree. Meanwhile, the data analysis regarding the successfulness of business showed that most of the Javanese entrepreneurs reached a high level of success, Chinese entrepreneurs were average, and Minangnese entrepreneurs were low.
Impact of Corporate Governance on Corporate Sustainable Growth
Authors: Mukherjee Tutun , Sen Som Sankar 
Published: July 2019

It is believed that good corporate governance practices assist significantly in uplifting corporate performance, and brings in business success and sustainability. This study aims to shed light on the impact of corporate governance practices on corporate sustainable growth in India. A sample size of leading 139 non-financial companies listed in NSE for five years has been used in this study. Using longitudinal data analysis, the findings of the study suggest that Board Size (BS) and the Board Independence (B-IND) exercise strong influence in explaining the Corporate Sustainable Growth in India after controlling the effect of Leverage (LEV).
Model of Corporate Value Improvement Through Investment Opportunity in Manufacturing Company Sector
Authors: Faozi Imam , Ghoniyah Nunung 
Published: July 2019

This study aims to analyze the significance of the direct and indirect effect of institutional ownership (INST), profitability (ROI), funding policy (DER), and dividend policy (Tobin’s Q) through investment opportunity (MV/BVE). The research data used 21 samples of manufacturing companies listed on the Indonesia Stock Exchange (IDX) during the 2012-2016 period. Data analysis used path analysis with the help of EViews 9 and Sobel test to know the effect of investment opportunity as an intervening variable. The interpretation findings of the first line analysis model show that Profitability directly affects positively and significantly on Corporate Value. Whereas, based on second-line analysis model, Funding Policy and Dividend Policy indirectly have significant effects on Corporate Value through Investment Opportunity variable. Simultaneously, all independent variables affect 97.45% of Investment Opportunities and amounted to 97.97% of Corporate Value through Investment Opportunities.
UN MODELO PARA LA DETERMINACIÓN DEL RIESGO CREDITICIO MUNICIPAL EN MÉXICO
Authors: Hernández Trillo Fausto , Vargas Bruno 
Published: July 2019

<p>Este trabajo desarrolla un método alternativo para medir el riesgo financiero de los municipios mexicanos. Esto se hace en vista del cambio de normas y reglas que la Comisión Nacional Bancaria y de Valores (cnbv) ha emitido para calcularlo. La metodología es una combinación de análisis de componentes principales con <em>credit</em> <em>scoring</em>. Los resultados se comparan con los de una de las calificadoras de crédito y son robustos.</p><p> </p><strong>T</strong>his work develops an alternative methodology to measure the financial risk of Mexican Municipalities. This is done in response to the change in Mexican financial risk regulation issued by the authority. The idea is to combine a Principal components model with credit scoring. Results are then compared to those of one of the rating agencies’ and yield robust estimations.
Analisis Faktor-Faktor yang Mempengaruhi Loyalitas Pelanggan Pasar dengan Kepuasan Sebagai Variabel Intervening di Toko Abang-Adik
Authors: Siregar Nurintan Asyiah 
Published: July 2019

<p><em>The purpose of this study was to determine the effect of product quality and brand image on customer loyalty with customer satisfaction as an intervening variable. The study was conducted at Abang-Adik Store in Rantauprapat City, North Sumatra. The population used was all shop customers with a simple random sampling method obtained by 98 final samples. Path analysis with the SPSS Version 22 program is used for data processing. The results of the study prove that product quality and brand image have a positive effect on customer loyalty, product quality and brand image have a positive effect on customer satisfaction, customer satisfaction has a positive effect on customer loyalty. The results of the study also prove that customer satisfaction is an intervening variable on the relationship between product quality and brand image with customer loyalty.</em></p><p> </p><p>Tujuan penelitian ini adalah untuk mengetahui pengaruh kualitas produk dan brand image terhadap loyalitas pelanggan dengan kepuasan pelanggan sebagai variabel intervening. Penelitian dilakukan pada Toko Abang-Adik di Kota Rantauprapat Sumatera Utara. Populasi yang digunakan adalah seluruh pelanggan took dengan metode simple random sampling didaperoleh 98 sampel akhir. Analisis jalur dengan program SPSS Versi 22 digunakan untuk pengolahan data. Hasil penelitian membuktikan bahwa kualitas produk dan brand image berpengaruh positif terhadap loyalitas pelanggan, kualitas produk dan brand image berpengaruh positif terhadap kepuasan pelanggan, kepuasan pelanggan berpengaruh positif terhadap loyalitas pelanggan. Hasil penelitian juga membuktikan bahwa kepuasan pelanggan sebagai variabel intervening terhadap hubungan antara kualitas produk dan brand image tdengan loyalitas pelanggan.</p>
Pengaruh Kepemimpinan dan Motivasi Terhadap Kinerja Pegawai Dinas Prasarana Jalan dan Jembatan Wilayah Bukittinggi
Authors: Syaleh Hariman 
Published: July 2019

<em>This study aims to see "The influence of leadership and motivation on the performance of employees in the Department of road infrastructure and bridge area Bukittinggi". The number of population and samples in this study all employees of the Office of Road and Bridge Infrastructure Bukittinggi region as many as 32 people are all entered using the census method. Data were collected through questionnaires distribution with </em><em>l</em><em>ikert scale model then tested to validity and reliability of the questionnaire. Data analysis technique used is Multiple Linear Regression Analysis method, after passing the classical assumption test using SPSS program. In this study leadership (X1) and motivation (X2) as independent variables, performance (Y) as the dependent variable. The results of this study are a). Leadership has positive and significant effect there is employee performance that is equal to 0,222 with level signifikanness 0,026 &lt;0,05. b). Motivation have positive and significant effect there is employee performance that is equal to 0,782 with significance level 0,000 &lt;0,05, leadership and motivation together have positive significant effect to employee performance equal to 51,623 with significance level 0,000 &lt;0,05. Based on the conclusions obtained then it is suggested to the next researcher, if you want to do a similar research is expected to add other factors that can affect the performance of employees such as incentives, work environment, and others.</em><br /><p> </p><p>Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan dan motivasi terhadap kinerja pegawai di Dinas prasarana jalan dan jembatan wilayah Bukittinggi baik secara parsial maupun secara simultan. Jumlah populasi dan sampel dalam penelitan ini seluruh pegawai Kantor Dinas Prasarana Jalan dan Jembatan wilayah Bukittinggi sebanyak 32 orang dan semuanya digunakan sebagai responden dengan menggunakan metode sensus. Data dikumpulkan melalui penyebaran kuisioner dengan skala Likert kemudian diuji validitas dan reliabilitas dari kuisioner tersebut. Teknik analisis data yang digunakan adalah metode Analisis Regresi Linear Berganda, setelah melewati uji asumsi klasik dengan menggunakan program SPSS. Dalam penelitian ini kepemimpinan dan motivasi sebagai variabel independen, kinerja sebagai variabel dependen. Hasil dari penelitian ini membuktikan Kepemimpinan dan motivasi baik secara parsial dan simultan berpengaruh positif dan signifikan terdapat kinerja pegawai di Dinas prasarana jalan dan jembatan wilayah Bukittinggi.</p>
Pengaruh Word of Mouth (Talkers and Tools) Terhadap Keputusan Menggunakan Pelayanan Jasa GO-JEK
Authors: Lusia Putri Siska , Yossi Hastini Lasti 
Published: July 2019

<p><em>The purpose of this study was to analyze effect of WOM-Talkers of online transportation on using service of Go-Jek; to analyze effect of WOM-Tools of online transportation on using service of Go-Jek; and to analyze effect of word of mouth (WOM-Talkers and WOM-Tools) for taking decision on using service of Go-Jek. The data were collected from 384 respondents who has ever used Go-Jek for one years. The result of the study showed that (1) WOM-Talkers is positive and significant impact for taking decision on using service of Go-Jek; (2) WOM-Tools is positive and significant impact for taking decision on using service of Go-Jek; and (3) WOM-Talkers and WOM-Tools are stimultaneously have positive and significant for taking decision on using service of Go-Jek. The value of adjusted R Square indicators was 47.4%.</em></p><p><em><br /></em></p><p><em>Penelitian ini bertujuan untuk menganalisis pengaruh WOM-Talkers terhadap pengambilan keputusan penggunaan jasa transportasi online Go-Jek di Kota Padang, menganalisis pengaruh WOM-Tools terhadap pengambilan keputusan penggunaan jasa transportasi online Go-Jek di Kota Padang, dan menganalisis pengaruh WOM-Talkers dan WOM-Tools secara bersama-sama terhadap pengambilan keputusan penggunaan jasa transportasi online Go-Jek di Kota Padang. Penelitian ini melibatkan 384 responden yang pernah menggunakan Go-Jek selama 1 tahun. Hasil yang diperoleh dari penelitian adalah (1) WOM-Talkers berpengaruh positif dan signifikan terhadap keputusan pembelian; (2) WOM-Tools berpengaruh positif dan signifikan terhadap keputusan pembelian; dan (3) WOM-Talkers dan WOM-Tools mampu menjelaskan pengaruhnya terhadap Keputusan Pembelian sebesar 47.4%. </em></p>
MEMBANGUN TEKNOLOGI INFORMASI PERPUSTAKAAN DIGITAL BERBASIS WEB
Authors: Ispandi Ispandi 
Published: July 2019

Pemanfaatan fasilitas internet yang baik dapat mempermudah masyarakat dalam melakukan aktivitas, seperti kegiatan membaca buku yang berguna untuk menambah wawasan dan pengetahuan. Akan tetapi terkadang terhambat pada biaya untuk membeli buku yang diinginkan, oleh karena itu sistem perpustakaan merupakan hal yang tepat untuk masyarakat dalam menambah wawasan melalui buku tanpa perlu mengeluarkan biaya. Hasil permasalahan yang penulis dapatkan pada perpustakaan konvensional adalah diharuskannya meluangkan waktu untuk pergi ke perpustakaan dan mengeluarkan biaya untuk pergi ke perpustakaan bahkan hanya untuk menjadi anggota perpustakaan, oleh karena itu penulis tertarik untuk menyelesaikan permasalahan tersebut dengan membuat sistem informasi digital library berbasis website yang dapat diakses dimana saja dan kapan saja tanpa mengeluarkan biaya. Pembuatan website ini menggunakan framework PHP Codeigniter yang dapat membantu user maupun pengelola dalam membaca, meminjam dan mengembalikan buku. Metode yang digunakan pada pengembangan perangkat lunak ini menggunakan model waterfall yang terdiri dari lima tahap yaitu Requirement Analysis, System Design, Implementation, Integration & Testing, Dari data yang di kumpulkan mengenai e-library siswa siswi yang mecoba aplikasi e-library menerangkan bahwa 84% siswa siswi menyukai program e-library Karena membatu mereka dalam membaca tanpa harus ke pepustakaan. Dengan adanya layanan e-library diharapkan banyak orang yang gemar membaca.
English language instructors’ beliefs about the role of L1 in English language development and formal instruction in Croatia: A survey
Authors: Erk Mirna 
Published: July 2019

Abstract
Current understanding of second language acquisition processes is based on the position that second language learners rely and depend on their L1 as well as on all of their language-related experience. This paper presents results of a questionnaire study aimed to explore Croatian EFL instructors’ beliefs about the role of L1 in English language development and formal instruction. Data was further analysed in order to explore variables most likely to impact instructors’ belief systems (participants’ age and academic degree, students’ language level, learning setting). The findings point to a lack of professional consensus with regard to L1 use which is discussed and followed by practical implications.
PENGARUH PENAMBAHAN PROBIOTIK TERHADAP KUALITAS AIR BUANGAN BUDIDAYA UDANG MILIK PT. PULAU MAS KHATULISTIWA (STUDI KASUS: SUNGAI PINYUH, KABUPATEN MEMPAWAH)
Authors: Aatanti Ria Risti 
Published: July 2019

ABSTRAK Budidaya udang tambak merupakan komoditas yang sangat menjanjikan keuntungan, salah satu perusahaan tambak udang yang ada di Kalimantan Barat adalah tambak udang PT. Pulau Mas Khatulistiwa yang berada di Sungai Pinyuh. Pada proses budidaya udang tambak banyak menghasilkan bahan organik, tingginya bahan organik ini berasal dari sisa pakan (pellet) yang tidak habis, selain itu sisa metabolisme udang juga menghasilkan bahan organik. Oleh sebab itu untuk mengurangi bahan organik yang dihasilkan, PT Pulau Mas menambahkan probiotik (Bacillus sp.) ke dalam pakan udang. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan probiotik terhadap kualitas air buangan budidaya udang tambak dan juga pertumbuhan udang secara fisik. Tahapan penelitian ini yaitu pengumpulan data primer berupa pengambilan sampel air dan pengukuran berat udang. Pengambilan sampel kualitas air menggunakan metode grab sample pada dua kolam berbeda, yaitu kolam dengan penambahan probiotik dan kolam tanpa probiotik. Pengambilan sampel dilakukan dua kali yaitu pada saat udang berumur 2 bulan dan 3 bulan (panen). Adapun parameter yang diujikan yaitu BOD, COD, Amoniak, Nitrit dan pH. Berdasarkan hasil analisis diketahui bahwa penambahan probiotik pada pakan udang dapat mempenagruhi kualitas air buangan tambak udang, terlihat dari adanya penurunan konsentrasi yang lebih besar pada kolam dengan penambahan probiotik dibandingkan kolam tanpa probiotik. Kolam dengan probiotik dapat menurunkan BOD sebesar 92%, COD 92% dan Nitrit 75%, sedangkan penurunan yang terjadi pada kolam tanpa probiotik untuk parameter BOD hanya sebesar 74%, COD 69% dan Nitrit 88%. Penambahan probiotik pada pakan udang dapat mempengaruhi pertumbuhan udang. Udang dengan penambahan probiotik memiliki pertumbuhan rata - rata sebesar 0,624 gram/hari, sedangkan udang tanpa penambahan probiotik pertumbuhan rata - ratanya hanya sebesar 0,41 gram/hari. Kata – kata Kunci: Udang, Probiotik, Kualitas air
POTENSI GANGGUAN KESEHATAN POLISI LALU LINTAS AKIBAT KARBON MONOKSIDA (CO)
Authors: Setyowati Niken 
Published: July 2019

ABSTRAK Sektor transportasi merupakan sumber pencemaran udara terbesar diperkotaan, termasuk di Kota Pontianak yang mengalami pertambahan penduduk setiap tahunnya. Hal ini berpotensi meningkatkan polusi udara di Kota Pontianak, salah satunya adalah CO yang berasal dari emisi kendaraan bermotor. Salah satu kelompok masyarakat yang lingkungan kerjanya terpajan oleh CO adalah polisi lalu lintas. Tujuan penelitian ini adalah untuk mengetahui konsentrasi CO di 5 titik persimpangan jalan di Kota Pontianak yang merupakan lingkungan kerja polisi lalu lintas, mengetahui persentase COHb dan potensi gangguan kesehatan yang dialami polisi lalu lintas serta mengetahui korelasi antara kondisi kesehatan polisi lalu lintas dengan perilaku yang dilakukan sehari-hari. Jenis penelitan yang digunakan adalah metode statistik deskriptif dan analisis korelasi. Penelitian dilakukan setiap hari Senin-Jumat selama bulan April-Mei 2014, di 5 persimpangan jalan di Kota Pontianak menunjukkan angka konsentrasi CO tertinggi berada pada titik 5, yaitu persimpangan Jalan Tanjungpura-Jalan Veteran, yaitu sebesar 150.000 μg/Nm3. Nilai ini sudah melebihi ambang batas baku mutu udara yang ditetapkan yaitu sebesar 30.000 μg/Nm3. Persen COHb tertinggi yang didapat yaitu sebesar 3,28% yang tidak menimbulkan pengaruh atau gejala terhadap kesehatan. Analisis korelasi yang dilakukan menunjukan nilai sebesar 0,264 yang menunjukkan hubungan yang lemah, sehingga dampak CO yang dirasakan oleh responden pada saat mereka bertugas dijalan tidak dipengaruhi oleh perilaku yang dilakukan sehari-hari oleh responden, seperti merokok, berolahraga, mengkonsumsi suplemen dan menggunakan masker. Kata kunci: konsentrasi CO, persentase COHb, polisi lalu lintas.