bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing self-care adherence in patients with heart failure: a study protocol for developing a theory-based behaviour change intervention using the COM-B behaviour model (ACHIEVE study)
Authors: Herber Oliver Rudolf , Atkins Louise , Störk Stefan , Wilm Stefan 
Published: September 2018

IntroductionAlthough international guidelines recommend self-care as an integral part of routine heart failure management, and despite evidence supporting the positive outcomes related to self-care, patients are frequently unable to adhere. Self-care can be modified through behaviour change interventions (BCIs). However, previous self-care interventions have shown limited success in improving adherence to self-care, because they were neither theory-based nor well defined, which precludes the identification of underlying causal mechanisms as well as reproducibility of the intervention. Thus, our aim is to develop an intervention manual that contains theory-based BCIs that are well-defined using eight descriptors proposed to describe BCIs in a standardised way.Methods and analysisBCIs will be based on statements of findings derived through qualitative meta-summary techniques and a quantitative meta-analysis. These reviews will be used to extract factors (target behaviours) associated with self-care adherence/non-adherence. Extracted target behaviours will be mapped onto the ‘Capability, Opportunity, Motivation and Behaviour’ (COM-B) model to capture the underlying mechanisms involved. To develop approaches for change, the ‘Taxonomy of Behaviour Change Techniques’ will be used to allow effective mapping of the target behaviours onto established behaviour change techniques. Suggested BCIs will then be translated into locally relevant interventions using the Normalisation Process Theory to overcome the difficulties of implementing theoretically derived interventions into practice. Finally, a consensus development method will be employed to fine-tune the content and acceptability of the intervention manual to increase the likelihood of successfully piloting and implementing future BCIs into the German healthcare system.Ethics and disseminationThis study has been reviewed and approved by the Ethics Committee of the Medical Faculty of the Heinrich Heine University Düsseldorf, Germany (Ref #: 2018-30). The results will be disseminated via peer-reviewed journal publications, conference presentations and stakeholder engagement activities.Trial registration numberDRKS00014855; Pre-results.
Paediatric tuberculosis in Singapore: a retrospective review
Authors: Loh Sin Wee , Thoon Koh Cheng , Tan Natalie Woon Hui , Li Jiahui , Chong Chia Yin 
Published: September 2018

BackgroundTuberculosis (TB) is a major cause of mortality and morbidity in the world. Each case represents ongoing transmission and has a significant public health burden. We aim to examine the clinical profile of paediatric TB and compare pulmonary TB (PTB) with extrapulmonary TB (EPTB) in Singapore.MethodsA retrospective study of patients admitted to KK Women’s and Children’s Hospital, Singapore from January 2008 to September 2017 with active TB was undertaken. The clinical characteristics and outcomes of patients with PTB and EPTB were compared.ResultsSeventy-five patients were diagnosed as having active TB (49 (65%) with PTB and 26 (35%) with EPTB). Patients with EPTB were more likely than those with PTB to be younger (median age 5.1 (IQR 1.2–10.2) years vs 10.1 (IQR 3.5–13.5) years), immunodeficient (35% vs 6%), with a lower haemoglobin count (median 11.2 (IQR 10.2–11.9) g/dL vs 12.0 (IQR 10.5–13.9) g/dL), lower recovery rate (27% vs 57%) and required longer duration of treatment (median 12 (IQR 9–12) months vs 6 (IQR 6–9) months). Common clinical presentations of both PTB and EPTB were significant fever (27%), cough (33%) and weight loss (32%). Overall mortality was 8% with septic shock responsible for three of the six deaths.ConclusionEPTB is more common in the younger age group and is associated with a lower recovery rate.
Male-female differences in aortic valve and combined aortic valve/coronary surgery: a national cohort study in the Netherlands
Authors: Mokhles M Mostafa , Soloukey Tbalvandany Sadaf , Siregar Sabrina , Versteegh Michel I M , Noyez Luc , van Putte Bart , Vonk Alexander B A , Roos-Hesselink Jolien W , Bogers Ad J J C , Takkenberg Johanna J M 
Published: September 2018

ObjectiveThe outcome of female patients after adult cardiac surgery has been reported to be less favourable compared with the outcome of male patients. This study compares men with women with respect to patient and procedural characteristics and early mortality in a contemporary national cohort of patients who underwent aortic valve (AV) and combined aortic valve/coronary (CABG/AV) surgery.MethodsAll patients who underwent AV (n=8717, 56% male) or a combined CABG/AV surgery (n=5867, 67% male) in the Netherlands between January 2007 and December 2011 were included.ResultsIn both groups, women were generally older than men (p<0.001) and presented with higher logistic EuroSCORES. In isolated AV surgery, men and women had comparable in-hospital mortality (OR 1.20, 95% CI 0.90 to 1.61; p=0.220). In concomitant CABG/AV surgery, in-hospital mortality was higher in women compared with men (OR 2.00, 95% CI 1.44 to 2.79; p<0.001). The area under the curve for logistic EuroSCORE 1 was systematically higher for men versus women in isolated AV surgery 0.82 (95% CI 0.78 to 0.86) vs 0.75 (95% CI 0.69 to 0.80) and in concomitant CABG/AV surgery 0.78 (95% CI 0.73 to 0.82) vs 0.69 (95% CI 0.63 to 0.74). Finally, (the weight of) risk factors associated with in-hospital mortality differed between men and women.ConclusionsThere are substantial male-female differences in patient presentation and procedural aspects in isolated AV and concomitant CABG/AV surgery in the Netherlands. Further studies are necessary to explore the mechanisms underlying the observed differences. In addition, the observation that standard risk scores perform worse in women warrants exploration of male-female specific risk models for patients undergoing cardiac surgery.Brief title:
Expert opinion on livestock antimicrobial usage indications and patterns in Denmark, Portugal and Switzerland
Authors: Carmo Luís Pedro , Bouzalas Ilias , Nielsen Liza Rosenbaum , Alban Lis , Martins da Costa Paulo , Müntener Cedric , Schüpbach Gertraud , Abreu Yandy , Magouras Ioannis 
Published: September 2018

We aimed at describing antimicrobial usage patterns throughout livestock production cycles, and comparing them across three countries from Northern, Central and Southern Europe. Given the difficulties to collect such detailed usage data, an expert opinion was deemed the most appropriate study design. This study provides new insights into the time periods and indications for which specific antimicrobial substances are used in different livestock sectors.Veterinary experts (n=67) from different livestock sectors (broilers, pigs, dairy cattle and veal/fattening calves) and countries (Denmark, Portugal and Switzerland) replied to a questionnaire focusing on the time periods in the production cycle when antimicrobial substances were administered, and the respective indications for treatment.Our results showed that for several antimicrobials, between‐country and within‐country variations exist regarding the temporal distributions of treatments and indications for use. These differences were also true for several critically important antimicrobials, which is a matter of concern. Furthermore, differences between countries were also evident regarding the antimicrobial substances licensed.Based on our results, it is recommended to establish and promote treatment guidelines, invest in the prevention of diseases during critical moments of the production cycle and target undifferentiated use of antimicrobials. Moreover, discrepancies between countries should be further investigated to better understand the factors underlying the identified patterns and to distinguish prudent from non‐prudent use. The results can inform decision‐making with the aim to foster antimicrobial prudent use in the veterinary setting and, therefore, protect public health from the threat of antimicrobial resistance.
A small-scale tofu test for soybean breeding programs
Authors: Frégeau-Reid J.A. , Cober E.R. 
Published: September 2018

Soybean breeding programs targeting tofu production must identify cultivars that are well suited for making tofu. A small-scale (SS) test of tofu texture was developed to evaluate breeding lines. The SS tofu test was developed to complement the larger scale Harrow tofu test but to use smaller samples of seed and soymilk to make tofu. The SS tofu test uses both magnesium chloride (MgCl2) and glucono-delta-lactone (GDL) coagulants to produce tofu samples of 20 mL. In comparisons of the SS and Harrow tofu texture tests, using lines with varying protein subunit profiles, both tests ranked lines similarly. In plant breeding trials, the SS tofu test was useful in ranking varieties for tofu texture. Multiple-year testing should be used for a thorough evaluation of varieties. When the SS tofu test was used with a population of lines with a wide range of seed protein, GDL-coagulated tofu texture was independent of seed protein content; however, MgCl2-coagulated tofu texture was moderately inversely correlated with seed protein. With the SS test, it may be best to compare tofu texture within groups of lines with similar seed protein levels. The SS tofu test is useful to test tofu texture of breeding lines using small amounts of seed.
Braided Hopf algebras from twisting
Authors: Bochniak Arkadiusz , Sitarz Andrzej 
Published: September 2018

We show that a class of braided Hopf algebras, which includes the braided [Formula: see text] of [P. Kasprzak, R. Meyer, S. Roy and S. L. Woronowicz, Braided quantum [Formula: see text] groups, J. Noncommut. Geom. 10 (2016) 1161–1125], is obtained by twisting. We show further examples and demonstrate that twisting of bicovariant differential calculi gives braided bicovariant differential calculi.
The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies
Authors: Stubbs Matthew C. , Burn Timothy C. , Sparks Richard , Maduskuie Thomas , Diamond Sharon , Rupar Mark , Wen Xiaoming , Volgina Alla , Zolotarjova Nina , Waeltz Paul , Favata Margaret , Jalluri Ravi , Liu Huiqing , Liu Xuesong Mike , Li Jun , Collins Robert , Falahatpisheh Nikoo , Polam Padmaja , DiMatteo Darlise , Feldman Patricia , Dostalik Valerie , Thekkat Pramod , Gardiner Christine , He Xin , Li Yanlong , Covington Maryanne , Wynn Richard , Ruggeri Bruce , Yeleswaram Swamy , Xue Chu-Biao , Yao Wenqing , Combs Andrew P. , Huber Reid , Hollis Gregory , Scherle Peggy , Liu Phillip C.C. 
Published: September 2018

Abstract

Purpose:
Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated activity in diverse models of hematologic and solid tumors. We report the preclinical characterization of INCB054329, a structurally distinct BET inhibitor that has been investigated in phase I clinical trials.

Experimental Design:
We used multiple myeloma models to investigate vulnerabilities created by INCB054329 treatment that could inform rational combinations.

Results:
In addition to c-MYC, INCB054329 decreased expression of oncogenes FGFR3 and NSD2/MMSET/WHSC1, which are deregulated in t(4;14)-rearranged cell lines. The profound suppression of FGFR3 sensitized the t(4;14)-positive cell line OPM-2 to combined treatment with a fibroblast growth factor receptor inhibitor in vivo. In addition, we show that BET inhibition across multiple myeloma cell lines resulted in suppressed interleukin (IL)-6 Janus kinase–signal transducers and activators of transcription (JAK–STAT) signaling. INCB054329 displaced binding of BRD4 to the promoter of IL6 receptor (IL6R) leading to reduced levels of IL6R and diminished signaling through STAT3. Combination with JAK inhibitors (ruxolitinib or itacitinib) further reduced JAK–STAT signaling and synergized to inhibit myeloma cell growth in vitro and in vivo. This combination potentiated tumor growth inhibition in vivo, even in the MM1.S model of myeloma that is not intrinsically sensitive to JAK inhibition alone.

Conclusions:
Preclinical data reveal insights into vulnerabilities created in myeloma cells by BET protein inhibition and potential strategies that can be leveraged in clinical studies to enhance the activity of INCB054329.
Trastuzumab Emtansine (T-DM1) in Patients with Previously Treated HER2-Overexpressing Metastatic Non–Small Cell Lung Cancer: Efficacy, Safety, and Biomarkers
Authors: Peters Solange , Stahel Rolf , Bubendorf Lukas , Bonomi Philip , Villegas Augusto , Kowalski Dariusz M. , Baik Christina S. , Isla Dolores , Carpeno Javier De Castro , Garrido Pilar , Rittmeyer Achim , Tiseo Marcello , Meyenberg Christoph , de Haas Sanne , Lam Lisa H. , Lu Michael W. , Stinchcombe Thomas E. 
Published: September 2018

Abstract

Purpose:
HER2-targeted therapy is not standard of care for HER2-positive non–small cell lung cancer (NSCLC). This phase II study investigated efficacy and safety of the HER2-targeted antibody–drug conjugate trastuzumab emtansine (T-DM1) in patients with previously treated advanced HER2-overexpressing NSCLC.

Patients and Methods:
Eligible patients had HER2-overexpressing NSCLC (centrally tested IHC) and received previous platinum-based chemotherapy and targeted therapy in the case of EGFR mutation or ALK gene rearrangement. Patients were divided into cohorts based on HER2 IHC (2+, 3+). All patients received T-DM1 3.6 mg/kg intravenously every 3 weeks until disease progression or unacceptable toxicity. The primary endpoint was investigator-determined overall response rate (ORR) using RECIST v1.1.

Results:
Forty-nine patients received T-DM1 (29 IHC 2+, 20 IHC 3+). No treatment responses were observed in the IHC 2+ cohort. Four partial responses were observed in the IHC 3+ cohort (ORR, 20%; 95% confidence interval, 5.7%–43.7%). Clinical benefit rates were 7% and 30% in the IHC 2+ and 3+ cohorts, respectively. Response duration for the responders was 2.9, 7.3, 8.3, and 10.8 months. Median progression-free survival and overall survival were similar between cohorts. Three of 4 responders had HER2 gene amplification. No new safety signals were observed.

Conclusions:
T-DM1 showed a signal of activity in patients with HER2-overexpressing (IHC 3+) advanced NSCLC. Additional investigation into HER2 pathway alterations is needed to refine the target population for T-DM1 in NSCLC; however, HER2 IHC as a single parameter was an insufficient predictive biomarker.
Eculizumab Modifies Outcomes in Adults with Atypical Hemolytic Uremic Syndrome with Acute Kidney Injury
Authors: Cao Mercedes , Leite Bruna N. , Ferreiro Tamara , Calvo María , Fernández Constantino , Alonso Ángel , Rodriguez Alejandro , Salvador Pilar , Seijo Rocío , Pita Salvador , Arjona Emilia , Rodríguez de Córdoba Santiago , Valdés Cañedo Francisco 
Published: September 2018

<b><i>Background:</i></b> Atypical hemolytic uremic syndrome (aHUS) is a rare disease associated with congenital or acquired genetic abnormalities that result in uncontrolled complement activation, leading to thrombotic microangiopathy and kidney failure. Until recently, the only treatment was plasma exchange or plasma infusion (PE/PI), but 60% of patients died or had permanent kidney damage despite treatment. Eculizumab, a complement inhibitor, has shown promising results in aHUS. However, data are mainly extracted from case reports or studies of heterogeneous cohorts, and no direct comparison with PE/PI is available. <b><i>Methods:</i></b> An observational retrospective study of adult, dialysis-dependent aHUS patients with acute kidney injury (AKI) who were treated with either PE/PI alone or with second-line eculizumab in our center. We compared the effect of PE/PI and eculizumab on kidney function, hypertension, proteinuria, hematologic values, relapse, and death. <b><i>Results:</i></b> Thirty-one patients were included (females, 18; sporadic aHUS, 29; mean age, 46 ± 20 years). Twenty-six patients were treated with PE/PI alone, and 5 were deemed to be plasma-resistant and received eculizumab after stopping PE/PI. Among patients receiving eculizumab, 80% attained complete recovery of kidney function, 100% stopped dialysis, 20% had decreased proteinuria, and no patient relapsed (vs. 38.5, 50, 15.4, and 11.5%, respectively, of patients receiving only PE/PI). At 1-year of follow-up, no deaths had occurred in either group. <b><i>Conclusion:</i></b> Eculizumab shows greater efficacy than PE/PI alone for the treatment of adult aHUS patients with AKI. Prospective studies and meta-analyses are warranted to confirm our findings and set guidelines for treatment, monitoring, and maintenance.
Safety of Carbon Dioxide Insufflation during Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma
Authors: Takada Jun , Araki Hiroshi , Mizutani Taku , Ozawa Noritaka , Sugiyama Tomohiko , Kubota Masaya , Ibuka Takashi , Shimizu Masahito 
Published: September 2018

<b><i>Background:</i></b> Pulmonary dysfunction often accompanies esophageal squamous cell carcinoma (SCC). <b><i>Aims:</i></b> This study examined the use of carbon dioxide (CO<sub>2</sub>) insufflation and its safety during esophageal endoscopic submucosal dissection (ESD) while under conscious sedation. <b><i>Methods:</i></b> ESD using CO<sub>2</sub> insufflation (1.4 L/min) was performed in 102 consecutive esophageal SCC patients. Patients with a forced expiratory volume of 1.0 s/forced vital capacity (FEV<sub>1.0</sub>%) &#x3c; 70% or a vital capacity &#x3c; 80% were defined as having pulmonary dysfunction. Transcutaneous partial pressure of CO<sub>2</sub> (PtcCO<sub>2</sub>) was recorded before, during, and after ESD. <b><i>Results:</i></b> A history of smoking was found in 90 patients (88%), while 43 patients (42%) had pulmonary dysfunction. No significant differences were found between the pulmonary dysfunction and normal groups for the baseline PtcCO<sub>2</sub> before ESD, peak PtcCO<sub>2</sub> during ESD, and median PtcCO<sub>2</sub> after ESD. There was a significant correlation between the PtcCO<sub>2</sub> elevation from baseline and the ESD procedure time (<i>r</i> = 0.32, <i>p</i> &#x3c; 0.01), with the correlation for the pulmonary dysfunction group much stronger (<i>r</i> = 0.39, <i>p</i> &#x3c; 0.05) than that for the normal group (<i>r</i> = 0.30, <i>p</i> &#x3c; 0.01). Neither of the groups exhibited any differences for either the complication incidence or the hospital stay. <b><i>Conclusions:</i></b> Although the use of CO<sub>2</sub> insufflation during esophageal ESD under conscious sedation is safe with regard to the risk of complications, longer procedure times can potentially induce CO<sub>2</sub> retention in patients with obstructive lung disease. Thus, it is necessary to both shorten the procedure times and perform CO<sub>2</sub> monitoring.
Candeia, o projeto Quilombo e a militância antirracista nos anos 1970
Authors: Treece David 
Published: September 2018

Ao participar da ressurgência da militância antirracista em meados da década de 1970, o Grêmio Recreativo de Arte Negra Escola de Samba Quilombo, fundado pelo compositor e cantor Antônio Candeia Filho, se inspirava no grande exemplo histórico da resistência negra, ou seja, as comunidades de escravos rebeldes chamadas quilombos. Este ensaio reavalia as perspectivas do projeto Quilombo em relação ao antirracismo e à política identitária negra, e mostra como, no auge da ditadura militar, ele propunha uma visão progressista e democrática da resistência enquanto projeto criativo coletivo – tipificado culturalmente pela escola de samba comunitária e pela prática improvisatória colaborativa do samba de partido-alto –, que colocava no centro do seu ideário as tradições estéticas e filosóficas negras, ao passo que atravessava de aneira inclusiva as fronteiras raciais de cor.
Still Great: Subjective Intergenerational Mobility and Income Inequality
Authors: Bar-Haim Eyal 
Published: September 2018

AbstractIn recent years, the authors of several studies have established that income inequality is negatively associated with intergenerational income mobility in a phenomenon known as “The Great Gatsby Curve.” Yet, extant research on the effects of inequality and social mobility on people’s perceptions and social and political behavior has yielded contradicting results. In light of these inconsistencies, the aim of the current study was to evaluate the association between income inequality and subjective intergenerational mobility. Using data from 40 countries, the effect of income inequality on subjective mobility was examined, along with their combined effect on views regarding redistribution. The results indicated that income inequality increases mainly subjective downward mobility. The effect of subjective mobility on the attitudes toward redistribution was found to be substantial, but there were no significant results highlighting an interaction between inequality and subjective mobility. The results show how individual perceptions of opportunity inequalities are affected by the structural constraints of society. The social implications of these results are discussed herein.
Possible Relationship of Weakened Aleutian Low with Air Quality Improvement in Seoul, South Korea
Authors: Oh Hye-Ryun , Ho Chang-Hoi , Park Doo-Sun R. , Kim Jinwon , Song Chang-Keun , Hur Sun-Kyong 
Published: September 2018

AbstractCold-season air quality in Seoul, South Korea, has been improved noticeably between 2001 and 2015 with a near-50% decrease in the mean concentration of particulate matter with aerodynamic diameters ≤10 μm (PM10). Like the change in mean concentration, the occurrence frequency and intensity of the extreme-high-PM10 episodes exceeding 100 μg m−3 has significantly decreased as well. In addition to the multilateral efforts of the South Korean government to reduce air pollutant emissions, this study proposes that large-scale circulation changes also could have contributed to the air quality improvements. Specifically, the recent weakening of the Aleutian low may have intensified the tropospheric westerlies around the Korean Peninsula, resulting in a shorter residence time of particulate matter over South Korea. Thus, despite constant governmental effort to reduce pollutant emissions, the improvement in air quality over South Korea may be delayed if the Aleutian low recovers its past strength in the future. This study emphasizes the importance of the meteorological field in determining the air quality over South Korea.
Modernity, postmodernity, and an evolving spirituality
Authors: Phillips Timothy 
Published: September 2018

This article comes from chapter 1 of a DMin dissertation entitled “Evolutionary Theology and Revolutionary Worship,” which can be found in the Library of the Graduate Theological Union in Berkeley, CA. The dissertation uses evolution as a metaphor for its understanding of God, through which the modern mainline Church can claim its unique spiritual identity and find connections with evangelicals who increasingly see evolution as an apt description of their own spiritual experience. In order to transform the conversation about worship from “worship wars” toward a priority for authenticity, this article makes two basic claims related to the perceived decline of the modern mainline Church: (i) the emerging evangelical churches seek to embrace the culture of postmodernity while rejecting the postmodern philosophical stance; and (ii) while the values of the modern mainline Church may resonate with postmodernity, it is often stuck in its own culture of modernity.