bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why do staff and family think differently about quality of life in dementia? A qualitative study exploring perspectives in care homes
Authors: Robertson Sarah , Cooper Claudia , Hoe Juanita , Lord Kathryn , Rapaport Penny , Livingston Gill 
Published: August 2019

BackgroundQuality of life is important especially in incurable illness. In dementia, we often need proxy reports of quality of life, but we know little about how individuals make their judgements. In care homes, proxies may be staff providing care or relatives, but staff rate quality of life differently to family. To our knowledge, no one has explored this qualitatively, so we used qualitative interviews to explore why staff and family think differently about quality of life.MethodsWe interviewed 12 staff and 12 relatives who had provided proxy ratings of quality of life for people living with dementia in care homes in the Managing Agitation and Raising Quality of life (MARQUE) study. We asked why they had rated the resident's quality of life as “Very Good, Good, Fair, or Poor.” Using thematic analysis, we compared staff and relatives' proxy responses.ResultsFor staff, the concept of quality of life was often viewed synonymously with quality of care, influenced by their sense of responsibility and informed by their professional understanding. For relatives, quality of life was often judged in relation to how the person with dementia lived before diagnosis and was influenced by their perception of loss for the person with dementia and their own adjustment.ConclusionsProxy reports were influenced by rater's own contexts and experiences. This can enhance our understanding of widely used research tools, aid the evaluation of intervention outcomes, and indicate possible targets for improving perceived and actual quality of life of people with dementia.
Optimization of an inertance pulse tube refrigerator using the particle swarm optimization algorithm
Authors: Panda Debashis , Rout Sachindra Kumar 
Published: August 2019

AbstractIn this study, a particle swarm optimization method is employed to find the optimal operating parameters and geometrical parameters, which maximize the coefficient of performance (COP) of an inertance pulse tube refrigerator (IPTR). The considered decision variables of the IPTR are the charging pressure, which varies from 15 to 25 bar, operating frequency varying from 20 to 60 Hz, geometrical parameters, such as diameter varying from 15.0 to 25.00 mm, and length varying from 40.0 to 70 mm of the regenerator; diameter varying from 12.0 to 20.00 mm and length varying from 40.0 to 80 mm of the pulse tube; and diameter varying from 2.0 to 6.00 mm and length varying from 1.0 to 3.0 m of the inertance tube. A 1D numerical model, based on the finite volume discretization of governing equations has been selected to build the initial design matrix and solve the governing continuity, momentum, and energy equations. Analysis of variance is performed using the result obtained from the numerical simulation to visualize the variations of COP as a combination of various input parameters. It is observed that after optimizing the input parameters, the COP of the IPTR increases by 15.14%.
Exploring the predictability of range‐based volatility estimators using recurrent neural networks
Authors: Petneházi Gábor , Gáll József 
Published: August 2019

SummaryWe investigate the predictability of several range‐based stock volatility estimates and compare them with the standard close‐to‐close estimate, which is most commonly acknowledged as the volatility. The patterns of volatility changes are analysed using long short‐term memory recurrent neural networks, which are a state‐of‐the‐art method of sequence learning. We implement the analysis on all current constituents of the Dow Jones Industrial Average index and report averaged evaluation results. We find that the direction of changes in the values of range‐based estimates are more predictable than that of the estimate from daily closing values only.
Molecular design and optimization of hepatic cancer SLP76‐derived PLCγ1 SH3‐binding peptide with the systematic N‐substitution of peptide PXXP motif
Authors: Tang Wenqing , Zhao Zhiying , Wang Chen , Ye Tao , Yang Biwei 
Published: August 2019

AbstractThe phospholipase Cγ1 (PLCγ1) is essential for T‐cell signaling and activation in hepatic cancer immune response, which has a regulatory Src homology 3 (SH3) domain that can specifically recognize and interact with the PXXP‐containing decapeptide segment (185QPPVPPQRPM194, termed as SLP76185–194 peptide) of adaptor protein SLP76 following T‐cell receptor ligation. The isolated peptide can only bind to the PLCγ1 SH3 domain with a moderate affinity due to lack of protein context support. Instead of the traditional natural residue mutagenesis that is limited by low structural diversity and shifted target specificity, we herein attempt to improve the peptide affinity by replacing the two key proline residues Pro187 and Pro190 of SLP76185–194 PXXP motif with nonnatural N‐substituted amino acids, as the proline is the only endogenous N‐substituted amino acid. The replacement would increase peptide flexibility but can restore peptide activity by establishing additional interactions with the domain. Structural analysis reveals that the domain pocket can be divided into a large amphipathic region and a small negatively charged region; they accommodate hydrophobic, aromatic, polar, and moderate‐sized N‐substituted amino acid types. A systematic replacement combination profile between the peptide residues Pro187 and Pro190 is created by structural modeling, dynamics simulation, and energetics analysis, from which six improved and two reduced N‐substituted peptides as well as native SLP76185–194 peptide are identified and tested for their binding affinity to the recombinant protein of the human PLCγ1 SH3 domain using fluorescence‐based assays. Two N‐substituted peptides, SLP76185–194(N‐Leu187/N‐Gln190) and SLP76185–194(N‐Thr187/N‐Gln190), are designed to have high potency (Kd = 0.67 ± 0.18 and 1.7 ± 0.3 μM, respectively), with affinity improvement by, respectively, 8.5‐fold and 3.4‐fold relative to native peptide (Kd = 5.7 ± 1.2 μM).
Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice
Authors: Medeiros Priscila , de Freitas Renato Leonardo , Boccella Serena , Iannotta Monica , Belardo Carmela , Mazzitelli Mariacristina , Romano Rosaria , De Gregorio Danilo , Coimbra Norberto Cysne , Palazzo Enza , Maione Sabatino 
Published: August 2019

AbstractThe chronic constriction injury (CCI) of the sciatic nerve is a nerve injury‐based model of neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive deficits are associated with a functional reorganization of the medial prefrontal cortex (mPFC). Here, we have employed an adapted model of CCI by placing one single loose ligature around the sciatic nerve in mice for investigating the alterations in sensory, motor, affective, and cognitive behavior and in electrophysiological and biochemical properties in the prelimbic division (PrL) of the mPFC. Our adapted model of CCI induced mechanical allodynia, motor, and cognitive impairments and anxiety‐ and depression‐like behavior. In the PrL division of mPFC was observed an increase in GABA and a decrease in d‐aspartate levels. Moreover an increase in the activity of neurons responding to mechanical stimulation with an excitation, mPFC (+), and a decrease in those responding with an inhibition, mPFC (−), was found. Altogether these findings demonstrate that a single ligature around the sciatic nerve was able to induce sensory, affective, cognitive, biochemical, and functional alterations already observed in other neuropathic pain models and it may be an appropriate and easily reproducible model for studying neuropathic pain mechanisms and treatments.
Optically stimulated luminescence ages of the Hengyu site and their implications for anthropogenic activities in the Fuzhou Basin, South China
Authors: Jin Jianhui , Huang Yunming , Zhang Yong , Li Zhizhong , Fan Xuechun , Ling Zhiyong , Zheng Fei , Cheng Yan , Xu Xiaolin , Li Zhixing , Zhang Wenjing 
Published: August 2019

ABSTRACTThe chronologies of few Neolithic sites in the lower reaches of the Min River of China have been well investigated for the middle to late Holocene. In this study, the Hengyu Neolithic site in Fujian Province, South China, which has significant archaeological remains, was dated using blue‐stimulated optically stimulated luminescence (OSL) and accelerator mass spectrometry radiocarbon (AMS14C) techniques. The results, comprising nine OSL and three AMS14C ages through the Neolithic sequence, provide new evidence towards understanding the relationship between environmental evolution and human activities in the middle to late Holocene in the Fuzhou Basin and coastal areas of South China. The ages of the site deposits vary from 6.83 to 1.67 ka and can be divided into two main phases: the Keqiutou–Tanshishan culture period and the Bronze culture period. In contrast, the persistent periods of ancient human activities at the Hengyu site seem to correspond to regional sea‐level changes and the East Asian winter monsoon as a secondary factor, which can affect human activities through sea‐level impacts. The warm and high sea level conditions provided a liveable environment for the ancient humans of Fujian and even South China. The ages of two building column bases are linked to the early stage of the Han dynasty, suggesting a potentially favourable habitation environment; that is, ancient humans occupied and settled this area for the long term within this time period, which is consistent with sea‐level changes and palynology records. Copyright © 2019 John Wiley & Sons, Ltd.
Cache pilfering in a granivore guild: Implications for reintroduction management
Authors: Chock Rachel Y. , Grether Gregory F. , Shier Debra M. 
Published: August 2019

ABSTRACTReintroduction programs that release endangered species back into areas from which they have been extirpated rarely take competitive interactions between species into account. The endangered Pacific pocket mouse (Perognathus longimembris pacificus) is being reintroduced to parts of its former range where multiple species of native rodents have overlapping diets. The granivorous species in this foraging guild compete for seeds exploitatively and through direct interference interactions, and pocket mice are the smallest and least dominant species in the guild. Repeated aggressive interactions from resident heterospecifics could lower the chances of reintroduced pocket mice establishing burrows during the post‐release settlement period. As such, temporarily reducing the density of competing species through exclusionary fencing might be an advisable reintroduction strategy, in combination with other interventions, such as predator exclusion. The presence of other members of the seed‐foraging guild, however, could have a net benefit for pocket mice, if the pocket mice pilfer from the other species’ seed caches more than the other species pilfer from their caches. To test the frequency of cache pilfering between species, we conducted a field experiment with fluorescent dyed seeds. Two of 10 pocket mice pilfered from heterospecifics, but only 1 of 33 heterospecifics pilfered from pocket mice. In a field‐enclosure experiment, we could not conclude that any of the 4 species tested used heterospecific scent to find (or avoid) seed caches, and pocket mice were less efficient in pilfering from artificial caches, recovering fewer seeds than the larger species. We did not find strong evidence that Pacific pocket mice benefit from living in sympatry with larger, dominant species. Although further research is needed to elucidate the relationship between heterospecific density and the prevalence of cache pilfering, a conservative reintroduction approach would be to select receiver sites with low densities of known competitors to benefit pocket mice during the critical post‐release establishment phase. © 2019 The Wildlife Society.
Heparin therapy as adjuvant treatment for profound idiopathic sudden sensorineural hearing loss
Authors: Kim Junsuk , Jeong Jinuk , Ha Ryun , Sunwoo Woongsang 
Published: August 2019

Objectives/HypothesisThis study aimed to provide evidence of whether unfractionated heparin used as adjuvant therapy in conjunction with systemic corticosteroid therapy improves hearing recovery in patients with profound idiopathic sudden sensorineural hearing loss (ISSNHL), and to compare the effect of this treatment with those of additional intratympanic corticosteroid therapy.Study DesignRetrospective chart review.MethodsEighty‐seven patients with profound ISSNHL (≥90 dB) and who had been admitted at a tertiary referral center between 2010 and 2018 were retrospectively reviewed, 67 patients for additional intratympanic corticosteroid injection (ITSI) (ITSI group) and 21 for adjuvant heparin therapy (heparin group). Hearing recovery was evaluated by grade assessment according to the American Academy of Otolaryngology–Head and Neck Surgery criteria.ResultsOf the patients in the heparin group, 42.8% recovered serviceable hearing, which was significantly higher than the recovery rates (19.7%) of those in the ITSI group. Particularly, in patients with pretreatment hearing level of 90 to 100 dB, adjuvant heparin therapy enhanced therapeutic effects with a significant hearing recovery rate of 80%. However, in patients with initial hearing level >100 dB, the rates of significant hearing recovery in the two groups were roughly equal and remained unsatisfactory (8.1% in the ITSI group and 9.1% in the heparin group).ConclusionsThe results of this study suggest that the treatment of profound ISSNHL with adjuvant heparin therapy, in combination with systemic steroid therapy, results in higher hearing recovery rates when compared to combined local and systemic corticosteroid therapy, without serious complications.Level of Evidence3bLaryngoscope, 130:1310–1315, 2020
Effects of Deep Brain Stimulation on Postural Trunk Deformities: A Systematic Review
Authors: Lizarraga Karlo J. , Fasano Alfonso 
Published: August 2019

ABSTRACTBackgroundDeep brain stimulation (DBS) effects on postural deformities are still poorly explored.MethodsSystematic review in accord with the Preferred Reporting Items for Systematic review and Meta‐Analysis guidelines (PRISMA).ResultsAll 38 studies that met predefined eligibility criteria had high risk of bias attributed to retrospective analysis of heterogeneous populations with variable and incompletely reported demographic and clinical characteristics, definitions, outcomes, DBS indications, targets, and settings. Five patient groups were identified in the 35 studies with individual data available: (1) parkinsonian camptocormia (n = 96): 89 patients underwent subthalamic (STN) and 7 globus pallidus pars interna (GPi) DBS. Camptocormia was the indication in 3 patients. After DBS, camptocormia improved in 57 of 96 patients (4.3–100% improvement) and remained stable or worsened in 39 of 96 patients (2–100% worsening). (2) dystonic camptocormia (n = 16): All underwent GPi‐DBS. They were younger and with shorter disease duration, but longer deformity duration, compared with parkinsonian camptocormia. After GPi‐DBS, camptocormia improved in all patients (50–100% improvement). (3) Parkinsonian Pisa syndrome (n = 14): 11 patients underwent STN‐DBS for motor fluctuations whereas Pisa syndrome was the indication for pedunculopontine and GPi‐DBS in 2 patients. After DBS, Pisa improved in 10 of 14 patients (33.3–66.7% improvement). (4) Dystonic opisthotonus: 2 young patients remarkably responded to GPi‐DBS. (5) Parkinsonian anterocollis: There were variable responses in 3 patients after STN‐DBS for motor fluctuations.ConclusionsLow‐quality level of evidence suggests that dystonic camptocormia and opisthotonus improve after GPi‐DBS. Parkinsonian camptocormia, Pisa syndrome, and anterocollis have variable responses, and their dystonic features should be further explored.
Indicators of mental disorders in UK Biobank—A comparison of approaches
Authors: Davis Katrina A.S. , Cullen Breda , Adams Mark , Brailean Anamaria , Breen Gerome , Coleman Jonathan R.I. , Dregan Alexandru , Gaspar Héléna A. , Hübel Christopher , Lee William , McIntosh Andrew M. , Nolan John , Pearsall Robert , Hotopf Matthew 
Published: August 2019

AbstractObjectivesFor many research cohorts, it is not practical to provide a “gold‐standard” mental health diagnosis. It is therefore important for mental health research that potential alternative measures for ascertaining mental disorder status are understood.MethodsData from UK Biobank in those participants who had completed the online Mental Health Questionnaire (n = 157,363) were used to compare the classification of mental disorder by four methods: symptom‐based outcome (self‐complete based on diagnostic interviews), self‐reported diagnosis, hospital data linkage, and self‐report medication.ResultsParticipants self‐reporting any psychiatric diagnosis had elevated risk of any symptom‐based outcome. Cohen's κ between self‐reported diagnosis and symptom‐based outcome was 0.46 for depression, 0.28 for bipolar affective disorder, and 0.24 for anxiety. There were small numbers of participants uniquely identified by hospital data linkage and medication.ConclusionOur results confirm that ascertainment of mental disorder diagnosis in large cohorts such as UK Biobank is complex. There may not be one method of classification that is right for all circumstances, but an informed and transparent use of outcome measure(s) to suit each research question will maximise the potential of UK Biobank and other resources for mental health research.
What is wrong with job security?
Authors: Mussagulova Assel , van der Wal Zeger , Chen Chung‐An 
Published: August 2019

SummaryMost Western studies into motivation suggest that public servants are prosocial. Moreover, scholars suggest that a desire for external rewards, like pay and job security, may crowd out prosocial proclivity. However, recent studies from non‐Western contexts provide mixed results about the actual drivers of public servants' motivation to seek and retain public sector employment and perform their duties. To advance the development of theory regarding motivational dynamics of public servants in developing countries, we examine how pursuing external rewards impacts public service motivation, job satisfaction, and turnover intention among public servants in Kazakhstan (n= 627), a developing former Soviet republic that has been subjected to various waves of personnel reform. Our quantitative and qualitative data show that a desire for job security relates positively to public service motivation and job satisfaction, whereas a desire for monetary rewards correlates negatively with public service motivation and positively with turnover intention. We conclude with the implications for theory and practice.
CDC42 promotes vascular calcification in chronic kidney disease
Authors: Li Zehua , Wu Ji , Zhang Xiuli , Ou Caiwen , Zhong Xinglong , Chen Yanting , Lu Lihe , Liu Hailin , Li Yining , Liu Xiaoyu , Wu Bo , Wang Yuxi , Yang Pingzhen , Yan Jianyun , Chen Minsheng 
Published: August 2019

AbstractVascular calcification is prevalent in patients with chronic kidney disease (CKD) and a major risk factor of cardiovascular disease. Vascular calcification is now recognised as a biological process similar to bone formation involving osteogenic differentiation of vascular smooth muscle cells (VSMCs). Cell division cycle 42 (CDC42), a Rac1 family member GTPase, is essential for cartilage development during endochondral bone formation. However, whether CDC42 affects osteogenic differentiation of VSMCs and vascular calcification remains unknown. In the present study, we observed a significant increase in the expression of CDC42 both in rat VSMCs and in calcified arteries during vascular calcification. Alizarin red staining and calcium content assay revealed that adenovirus‐mediated CDC42 overexpression led to an apparent VSMC calcification in the presence of calcifying medium, accompanied with up‐regulation of bone‐related molecules including RUNX2 and BMP2. By contrast, inhibition of CDC42 by ML141 significantly blocked calcification of VSMCs in vitro and aortic rings ex vivo. Moreover, ML141 markedly attenuated vascular calcification in rats with CKD. Furthermore, pharmacological inhibition of AKT signal was shown to block CDC42‐induced VSMC calcification. These findings demonstrate for the first time that CDC42 contributes to vascular calcification through a mechanism involving AKT signalling; this uncovered a new function of CDC42 in regulating vascular calcification. This may provide a potential therapeutic target for the treatment of vascular calcification in the context of CKD. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The role of maladaptive personality domains across multiple levels of the HiTOP structure
Authors: Sellbom Martin , Carragher Natacha , Sunderland Matthew , Calear Alison L. , Batterham Philip J. 
Published: August 2019

AbstractThis study aimed to examine associations between maladaptive personality traits and psychopathology from the perspective of the hierarchical taxonomy of psychopathology (HiTOP). We tested hierarchical structural models to further validate a portion of the structural components of HiTOP. We also tested a priori personality and psychopathology associations with three levels of the HiTOP hierarchy: general psychopathology, spectra and syndromes/disorders. We used a large sample from the general Australian population who completed a large set of personality and psychopathology inventories online. Confirmatory factor analyses indicated that internalizing, externalizing and thought dysfunction spectra emerged structurally, as expected per HiTOP, but also revealed that obsessive‐compulsive disorder loaded on both internalizing and thought dysfunction and attention deficit hyperactivity disorder on both externalizing and internalizing. Furthermore, results indicated that almost all personality and psychopathology hypotheses were supported, although trait antagonism did not predict externalizing to the degree initially expected. Implications for personality and psychopathology are discussed. © 2019 John Wiley & Sons, Ltd.
Fault detection and estimation for a class of PIDE systems based on boundary observers
Authors: Xu Xiaodong , Yuan Yuan , Wang Meiling , Fu Mengyin , Dubljevic Stevan 
Published: August 2019

SummaryIn this paper, we propose a simultaneous state estimation and fault estimation approach for a class of first‐order hyperbolic partial integral differential equation systems. Specifically, we consider the multiplicative boundary actuator and sensor faults, ie, unknown fault parameters multiplying by the boundary input or boundary state (ie, output). As a consequence, two difficulties arise immediately: (1) simultaneous estimation of both plant state and faults is a nonlinear problem due to the multiplication between fault parameters and plant signals; (2) no prior information is available to determine the type (actuator or sensor) of faults. To overcome these difficulties, this paper develops adaptive fault parameter update laws and embeds the resulting laws into the plant state observer design. First, we propose new approaches to estimate actuator fault and sensor fault, respectively. Next, we develop a novel method to simultaneously estimate actuator and sensor faults. The proposed observer and update laws, designed using only one boundary measurement, ensure both state estimation and fault parameter estimation. By choosing appropriate Lyapunov functions, we prove that the estimates of state and fault parameters converge to an arbitrarily small neighborhood of their true values. Numerical simulations are used to demonstrate the effectiveness of the proposed estimation approaches.