bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endometrial injury for patients with endometriosis and polycystic ovary syndrome undergoing medically assisted reproduction: current data and a protocol
Authors: Siristatidis Charalampos , Rigos Ioannis , Pergialiotis Vasilios , Karageorgiou Vasilios , Christoforidis Nikolaos , Daskalakis George , Bettocchi Stefano , Makrigiannakis Antonis 
Published: September 2018

Abstract
We propose a study protocol capable of improving clinical outcomes following medically assisted reproduction (MAR) in infertile women with endometriosis and polycystic ovary syndrome (PCOS). The proposed research derives from the published evidence on the positive impact from endometrial injury (EI) and the beneficial nature of the intervention towards improved implantation rates. We primarily refer to the cluster of events and hypotheses, such as the mechanical cascade, the inflammatory response per se, the events accompanying wound healing, the immune cell recruitment and protein involvement, alterations in gene expression and the neo-angiogenesis theories, which have been previously investigated for this purpose. We are also exploring the possible problems in MAR cycles with negative outcomes in PCOS and endometriosis patients and we are proposing potential mechanisms on how this intervention might work. Our hypothesis states that the EI before the initiation of the MAR cycle can affect clinical pregnancy rates in patients with the aforementioned pathologies.
Interplay between reversible phosphorylation and irreversible ADP-ribosylation of eukaryotic translation elongation factor 2
Authors: Mateus-Seidl Rita , Stahl Sebastian , Dengl Stefan , Birzele Fabian , Herrmuth Hedda , Mayer Klaus , Niederfellner Gerhard , Liu Xiu-Fen , Pastan Ira , Brinkmann Ulrich 
Published: September 2018

Abstract
The functionality of eukaryotic translation elongation factor 2 (eEF2) is modulated by phosphorylation, eEF2 is simultaneously the molecular target of ADP-ribosylating toxins. We analyzed the interplay between phosphorylation and diphthamide-dependent ADP-ribosylation. Phosphorylation does not require diphthamide, eEF2 without it still becomes phosphorylated. ADP-ribosylation not only modifies the H715 diphthamide but also inhibits phosphorylation of S595 located in proximity to H715, and stimulates phosphorylation of T56. S595 can be phosphorylated by CDK2 and CDK1 which affects EEF2K-mediated T56-phosphorylation. Thus, ADP-ribosylation and S595-phosphorylation by kinases occur within the same vicinity and both trigger T56-phosphorylation. Diphthamide is surface-accessible permitting access to ADP-ribosylating enzymes, the adjacent S595 side chain extends into the interior. This orientation is incompatible with phosphorylation, neither allowing kinase access nor phosphate attachment. S595 phosphorylation must therefore be accompanied by structural alterations affecting the interface to ADP-ribosylating toxins. In agreement with that, replacement of S595 with Ala, Glu or Asp prevents ADP-ribosylation. Phosphorylation (starvation) as well as ADP-ribosylation (toxins) inhibit protein synthesis, both affect the S595/H715 region of eEF2, both trigger T57-phosphorylation eliciting similar transcriptional responses. Phosphorylation is short lived while ADP-ribosylation is stable. Thus, phosphorylation of the S595/H715 ‘modifier region’ triggers transient interruption of translation while ADP-ribosylation arrests irreversibly.
Synthetic Control Method: Inference, Sensitivity Analysis and Confidence Sets
Authors: Firpo Sergio , Possebom Vitor 
Published: September 2018

Abstract
We extend the inference procedure for the synthetic control method in two ways. First, we propose parametric weights for the p-value that includes the equal weights benchmark of Abadie et al. [1]. By changing the value of this parameter, we can analyze the sensitivity of the test’s result to deviations from the equal weights benchmark. Second, we modify the RMSPE statistic to test any sharp null hypothesis, including, as a specific case, the null hypothesis of no effect whatsoever analyzed by Abadie et al. [1]. Based on this last extension, we invert the test statistic to estimate confidence sets that quickly show the point-estimates’ precision, and the test’s significance and robustness. We also extend these two tools to other test statistics and to problems with multiple outcome variables or multiple treated units. Furthermore, in a Monte Carlo experiment, we find that the RMSPE statistic has good properties with respect to size, power and robustness. Finally, we illustrate the usefulness of our proposed tools by reanalyzing the economic impact of ETA’s terrorism in the Basque Country, studied first by Abadie and Gardeazabal [2] and Abadie et al. [3].
Modeling and Simulating the Aerobic Carbon Metabolism of a Green Microalga Using Petri Nets and New Concepts of VANESA
Authors: Brinkrolf Christoph , Henke Nadja A. , Ochel Lennart , Pucker Boas , Kruse Olaf , Lutter Petra 
Published: September 2018

Abstract
In this work we present new concepts of VANESA, a tool for modeling and simulation in systems biology. We provide a convenient way to handle mathematical expressions and take physical units into account. Simulation and result management has been improved, and syntax and consistency checks, based on physical units, reduce modeling errors. As a proof of concept, essential components of the aerobic carbon metabolism of the green microalga Chlamydomonas reinhardtii are modeled and simulated. The modeling process is based on xHPN Petri net formalism and simulation is performed with OpenModelica, a powerful environment and compiler for Modelica. VANESA, as well as OpenModelica, is open source, free-of-charge for non-commercial use, and is available at: http://agbi.techfak.uni-bielefeld.de/vanesa.
Optoelectronics with single layer group-VIB transition metal dichalcogenides
Authors: Khan M.A. , Leuenberger Michael N. 
Published: September 2018

Abstract
The discovery of two-dimensional (2D) materials has opened up new frontiers and challenges for exploring fundamental research. Recently, single-layer (SL) transition metal dichalcogenides (TMDCs) have emerged as candidate materials for electronic and optoelectronic applications. In contrast to graphene, SL TMDCs have sizable band gaps that change from indirect to direct in SLs, which is useful in making thinner and more efficient electronic devices, such as transistors, photodetectors, and electroluminescent devices. In addition, SL TMDCs show strong spin-orbit coupling effects at the valence band edges, giving rise to the observation of valley-selective optical excitations. Here, we review the basic electronic and optical properties of pure and defected group-VIB SL TMDCs, with emphasis on the strong excitonic effects and their prospect for future optoelectronic devices.
Numerical Analysis of Peristaltic Transport of Casson Fluid for non-zero Reynolds Number in Presence of the Magnetic Field
Authors: Javed T. , Ahmed B. , Hamid A.H. , Sajid M. 
Published: September 2018

Abstract
In this study, the peristaltic flow of a Casson fluid in a channel is considered in the presence of an applied magnetic field. Flow is considered in the moving frame of reference with constant velocity along the wave. The developed mathematical model is presented by a set of partial differential equations. A numerical algorithm based on finite element method is implemented to evaluate the numerical solution of the governing partial differential equations in the stream-vorticity formulation. The obtained results are independent of low Reynolds number and long wavelength assumptions, so the effects of non-zero moderate Reynolds number are presented. The expression for the pressure is also calculated implicitly and discussed through graphs. Computed solutions are presented in the form of contours of streamlines and vorticity. Velocity profile and pressure distribution for variation of different involved parameters are also presented through graphs. The investigation shows that the strength of circulation for stream function increases by increasing the Reynolds and Hartmann numbers. Enhancement in longitudinal velocity is noted by increasing the Reynolds number and Casson parameter while increasing Hartmann number reduces the longitudinal velocity. Comparison of the present results with the available results in literature is also included and found in good agreement.
Phase I/II study of oxaliplatin dose escalation via a laparoscopic approach using pressurized aerosol intraperitoneal chemotherapy (PIPOX trial) for nonresectable peritoneal metastases of digestive cancers (stomach, small bowel and colorectal): Rationale and design
Authors: Dumont Frédéric , Senellart Hélène , Pein Francois , Campion Loic , Glehen Olivier , Goere Diane , Pocard Marc , Thibaudeau Emilie 
Published: September 2018

AbstractBackgroundThe annual incidence of gastrointestinal carcinomas (stomach, small bowel, colon and rectum) is increasing in Western countries, reaching 50,000 new cases each year in France. Peritoneal carcinomatosis (PC) is diagnosed in 15% of these patients. Complete cytoreductive surgery (CCS) plus Hyperthermic IntraPeritoneal Chemotherapy (HIPEC) is the only therapy that can offer patients with PC a chance for long-term survival with a 5 year overall survival (OS) rate of 30–60% versus 0–5% with systemic chemotherapy alone. However, CCS plus HIPEC still presents serious limitations and very few patients (10%) are candidates for these radical treatments. PC remains a palliative setting for 90% of patients with a median survival ranging from 15 to 25 months. Innovative surgical therapies such as Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) therefore need to be developed to improve the prognosis. Potential benefits were obtained after intraperitoneal nebulization of oxaliplatin in patients with advanced PC from colorectal cancer. Innovative surgical therapies such as pressurized intraperitoneal aerosol chemotherapy (PIPAC) have been proposed as palliative locoregional treatment with some promising results. The dose of oxaliplatin currently established by nebulization (PIPAC) is really low at 92 mg/m2. However, the peritoneum acts as a barrier limiting the systemic passage of intraperitoneal drug. Oxaliplatin used at higher doses during PIPAC procedures could be a safe option and allow better intratumoral penetration of chemotherapy.Method and designThe proposed study is a multicenter phase I/II trial of oxaliplatin dose escalation during PIPAC. The aim is to determine the maximum tolerated dose of pressurized oxaliplatin administered by the intraperitoneal route (PIPAC) during two consecutive procedures at a 4–6 week interval for patients with extended peritoneal carcinomatosis from the gastrointestinal tract. Dose started at 90 mg/m2and escalation was in 50 mg/m2steps up to a maximum of 300 mg/m2.DiscussionOxaliplatin is an effective drug in gastrointestinal cancer and high doses given by the intraperitoneal route during HIPEC are well tolerated. In this phase I trial, we hypothesized that high-dose oxaliplatin during PIPAC is feasible and safe. The repeated local administration of high doses of oxaliplatin could improve tumor response and prognosis.Trial registrationProspective study. ClinicalTrials.gov: NCT03294252. EudraCT: 2016-003666-49
Invasive species or sustainable water filters? A student-led laboratory investigation into locally sourced biomass-based adsorbents for sustainable water treatment
Authors: Berger Michael , Karod Madeline , Goldfarb Jillian L. 
Published: September 2018

AbstractDesigning sustainable products requires a holistic consideration of issues at the Food-Energy-Water Nexus. One of the world’s greatest challenges is to insure clean water access for all inhabitants. Across the globe, communities often suffer from metal contamination in their water. We must develop low-cost, sustainable materials to treat this contamination, without putting undue stress on other systems. Biomass-based carbon adsorbents are often touted as one potential solution, but to be sustainable the biomass must be locally sourced, not grown on land that could be used to cultivate food, not require extensive water to grow, and not need undue amounts of energy to process. In this laboratory investigation, students were challenged to use a locally available, problematic biomass –phragmites, an invasive species in the Muddy River in Boston, Massachusetts – to develop a green adsorbent to remove metals from water. Specifically, students focused on the removal of manganese, as it is a local problem for several Massachusetts communities. Students activated thephragmitesbiomass using a room and low (40 °C) temperature KOH treatment, which opened the porous network of the reed to enable adsorption of Mn+2upwards of 8 mg/g of biomass. In doing this experiment, students were exposed to the concept of adsorption, a separation process not often covered in the traditional chemistry curriculum. Students gained experience in performing adsorption isotherm experiments using atomic adsorption spectroscopy and UV–Vis spectrophotometry and learned to analyze data within adsorption isotherm models. Finally, students made connections between their laboratory data and adsorption theory, and how this data can be used to design greener materials to address environmental issues.
Quality of life and sexual life in women with advanced stage pelvic organ prolapse
Authors: AVCIBAY VURGEÇ Burcu , KIZILKAYA BEJİ Nezihe 
Published: September 2018

Purpose: This study aims to evaluate women with pelvic organ prolapse in terms of the risk factors and identify the effects of pelvic organ prolapse on quality of life and sexual function. Materials and Methods: Target population of the study was women who applied to the gynecology polyclinics in a university hospital and maternity and children hospital. The study was completed with 110 control and 81 case group participants. The data were collected through Personal Identification Form, Pelvic Floor Distress Inventroy-20 (PFDI-20), Prolapse Quality of Life Scale (P-QOL), Pelvic Organ Prolapse / Urinary Incontinence Sexual Function Questionnaire (PISQ-12) and Female Sexual Function Inventory (FSFI). Results: Study results show that as pelvic floor dysfunction increases, quality of life decreases and sexual function is affected negatively. The difference in the general mean scores of questionnaires life quality and sexual dysfunction between the case and control groups was found to be statistically significant. POP prevalence decreases 1.6 times with the decrease in the number of pregnancies; it decreases 3.5 times with the decrease in the number of deliveries; and assisted delivery increases 2.8 times and increases 5.8 times if there is family history.Conclusion: Given the relationship between pelvic floor dysfunction and quality of life and sexuality it is possible to say that this is not only a medical problem but also a social problem. In this regard, it is important that both health professionals and women have prior knowledge of the risks about in terms of reducing the risk of encountering POP.
Hemşirelik öğrencilerinde Beyin Göçüne Yönelik Tutum Ölçeği geliştirilmesi: güvenirlik ve geçerlik çalışması
Authors: ÖNCÜ Emine , SELVİ Hüseyin , K. VAYISOĞLU Sümbüle , CEYHAN Halil 
Published: September 2018

maç: Bu çalışmanın amacı, hemşirelik öğrencilerinin beyin göçüne ilişkin tutumlarını belirlemeye yönelik bir ölçek geliştirmektir. Gereç ve Yöntem: Araştırma 01.03.2018- 25.04.2018 tarihleri arasında yapılmıştır. Çalışmaya hemşirelik lisans programı 1- 4. sınıflarda okuyan ve amaçlı örnekleme yöntemiyle belirlenen 423 öğrenci katılmıştır. Araştırmanın verileri 5’li likert tipinde 35 madde içeren denemelik ölçek formdan elde edilmiştir. Bulgular: Ölçeğin faktör analizine uygunluğu “Kaiser-Meyer-Olkin katsayısı” ve “Barlett Sphericity Testi” ile değerlendirilmiştir. Açımlayıcı faktör analizi sonucunda 19 maddenin ölçekten çıkarılmasıyla kalan 16 maddelik taslak ölçek, toplam varyansın % 51’ini açıklamaktadır. Maddeler “itici ve çekici faktörler” olarak iki bileşen altında toplanmıştır. Ölçeğin faktör yükleri 0.93 ile 0.37, düzeltilmiş madde- toplam korelasyonları ise 0.81 ile 0.34 arasında değişmektedir. Ölçeğin Cronbach Alfa güvenirliliği, bütüne ilişkin 0.91 ve alt bileşenlerine ilişkin 0.88 ve 0.86’dır. Ölçeğin geçerlilik kanıtlarını arttırmak için 396 hemşirelik öğrencisinden toplanan yeni verilerle yapılan doğrulayıcı faktör analizi sonuçları, faktör yapısının veriyle uyumlu olduğunu ortaya koymuştur (χ2/ sd= 3.68, RMSEA=0.083, CFI=0.97, NFI=0.96, GFI=0.89, AGFI= 0.86). Sonuç: Hemşirelik öğrencilerinin beyin göçüne ilişkin tutumunu değerlendirmek üzere geliştirilen ölçeğin güvenilir ve geçerli bir ölçek olduğu sonucuna varılmıştır. Ölçek daha farklı örneklem gruplarında da denenmelidir.
Effect of laparoscopic hysterectomy on sexual function and quality of life: 12-month follow-up results
Authors: SUKGEN Gökmen , ELLİBEŞ KAYA Aşkı 
Published: September 2018

Purpose: The purpose of this study is to investigate the effect of laparoscopic hysterectomy for benign reasons on the quality of life and sexual function of the patients with 12-month follow-up results.Materials and Methods: This prospective cohort study included 28 patients who had a laparoscopic hysterectomy. The participants` quality of life and sexual function level was measured with the Female Sexual Function Index (FSFI) and Short Form 36 Quality of Life Scale (SF-36) before and the first year after the operation. Results: There were no significant differences on the participants` sexual function scores between preoperation, and the first year after the operation. Although there was an improvement in all of the sub-domain scores, only sexual desire scores decreased after the operations, but these results were not statistically significant. However, quality of life scores, in all sub-domains, significantly increased after the surgery except the vitality. The vitality scores of the participants decreased.Conclusion: There is no effect of laparoscopic hysterectomy on sexual functioning, and there is a positive effect on the quality of life in the 12-month follow-up.
Elektromanyetik Navigasyon Diyagnostik Bronkoskopi (ENB)
Authors: Kanbur Metin Serda , Tezel Çağatay 
Published: September 2018

Bilgisayar teknolojisindeki ilerlemeler, spiral toraks bilgisayarlı (BT)
tomografisinden elde edilen verilerin kullanılarak, trakeobronşiyal ağacın
sanal gerçeklikteki görüntülerinin oluşturulmasına imkan tanımaktadır. Periferik
pulmoner lezyonlar yapılan görüntüleme tekniklerinde raslantısal olarak yaygın
şekilde görülmektedir. Bu lezyonların
giderek artan sıklıkta görülmesi, direk grafilerden üç kat daha duyarlı olan BT
kullanımını artırmaktadır. Yeni bir bronkoskopik teknik olan elektromanyetik navigasyon diyagnostik
bronkoskopi (ENB), periferal pulmoner lezyonlarda doğru tanı oranını artırmada
gelecek vadeden bir yöntem olmaya başlamıştır. Bu lezyonların tanısında yaygın
olarak kullanılan BT eşliğinde yapılan ince iğne aspirasyon biyopsisi (TTİAB),
malign lezyonlarda %90 sensitiviteye sahipken %20 ila 30 oranında yanlış negatiflik
oranına sahiptir. Ayrıca bu yöntem yaklaşık %25 oranında minör pnömotoraksa yol
açmaktayken, %5 oranında göğüs tüpü drenajına gerek duyulmaktadır. Bronkoskopik
tekniklerin, transtorasik biyopsiye göre ana avantajı daha üstün bir güvenliğe
sahip olmasıdır. Elektromanyetik navigasyon diyagnostik bronkoskopi (ENB), ek
floroskopik yöntem kullanmadan, özellikle inoperabl hastalarda erken tanı
doğruluğunu artırmada faydalı olabilir.
KONSEP KEPEMIMPINAN BERBASIS BUDAYA ISLAM JAWA
Authors: Mulyono Mulyono 
Published: September 2018

<p>Leadership concept based on Javanese-Islamic culture, one of them stem from Wali Songo representing leadership concept having integrity in character such as the king title of Demak: Sayyidin Panata Gama, Senapati Ing Ngalogo, Khalifatullah Fil-Ardh (Most powerful in ruling the religion, commander in battlefield, the leader on earth). The concept of leadership having integrity for Javanese society <br />represents a solid figure in religion, as a moslem scholar, war lord and king as well. The richness of Javanese cultures<br />have leadership values represented in those criteria through brief expression which is full of meaning. In democratic era and local autonomy in this time, this concept of leadership based on the values of Javanese culture is significant to study as a means to accomodate dynamics of plural society of Nusantara, so that it has bargaining position of leadership in modern Indonesia.</p><p> </p><p>Konsep kepemimpinan berdasarkan budaya Jawa-Islam, salah satunya berasal dari Wali Songo yang mewakili konsep kepemimpinan yang memiliki integritas dalam karakter seperti gelar raja Demak: Sayyidin Panata Gama, Senapati Ing Ngalogo, Khalifatullah Fil-Ardh (Paling berkuasa dalam memerintah agama, komandan di medan perang, pemimpin di bumi). Konsep kepemimpinan yang memiliki integritas untuk masyarakat Jawa mewakili sosok yang solid dalam agama, sebagai seorang ulama, raja dan pimpinan perang juga. Kekayaan budaya Jawa memiliki nilai-nilai kepemimpinan yang diwakili dalam kriteria tersebut melalui ekspresi singkat yang penuh makna. Dalam era demokrasi dan otonomi daerah saat ini, konsep kepemimpinan yang didasarkan pada nilai-nilai budaya Jawa signifikan untuk dipelajari sebagai sarana untuk mengakomodir dinamika masyarakat plural Nusantara, sehingga memiliki posisi tawar kepemimpinan Indonesia modern.</p>
WILLOW TRIANDRA (SALIX TRIANDRA L.): PROSPECTS AND OPPORTUNITIES FOR USE IN MEDICINE AND PHARMACY
Authors: Sannikova E. G. , Popova O. I. , Kompantseva E. V. 
Published: September 2018

One of the most promising plants for expanding the range of medicines having astringent and anti-inflammatory effects are various species of willow, which have been used in folk medicine for a long time and now arewidely appliedin the composition of various biologically active additives to food both abroad and in Russia. Currently, in medical practice, white willow (Salix alba L.) is mainly used. Numerous species of willow that grow and are widely cultivated in the Russian Federation have not yet been widely used in medicine.The aim of the studyis to summarize the literary data about the expansion habitat, the content of biologically active substances and the possibility of harvesting raw materials of willow triandra (Salix triandra L.) and its use in medicine and pharmacy.Materials and methods.The object of the study is willow triandra (S. triandra L.) widespread in the Russian Federation. The study was conducted using search and information and library databases (eLibrary, PubMed, CyberLeninka, ResearchGate).Results and discussion.Willow triandra (Salix triandra L.) is a perennial dioecious plant, belonging to the Salicaceae family (Willow), Amygdalinae section. The natural habitat of willow triandra is predominantly forest and forest-steppe zones of the European and Asian continents. Eastern Europe is the geographical center of the growth of willow triandra, where it occurs throughout the territory. In Russia, willow triandra occupies almost the whole of its European part, in the North extends as far as the Petrozavodsk-Vologda-Kirov line, and the North Caucasus, it can be found on the territory of Western and Central Siberia. This suggests the idea that plant resources of willow triandra are significant. The possibility of cultivation of willow triandra in various edaphic-phytocenotic conditions is noted, since it is most easily subjected to vegetative propagation. It has been pointed out that willow triandra, like other willow species, contains a rich complex of polyphenolic compounds, which causes its anti-inflammatory effect. It has been revealed that in efficiency, the branches are not inferior to the bark of the species under study, which makes it possible to use branches of various willow speciesas a medicinal plant material.Conclusion.The prospect of research of branches of various willow species, including willow triandra, as a medicinal plant raw material showing anti-inflammatory properties, is confirmed.