bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural, spectral and docking studies of a coordination polymer of zinc(II) formed by a pyridine-derived linker
Authors: Marandi Farzin , Moeini Keyvan , Alizadeh Fereshteh , Mardani Zahra , Quah Ching Kheng , Loh Wan-Sin 
Published: May 2018

Abstract
A mixed ligand zinc coordination polymer, {Zn(μ-DPE)(DBM)2}
n
(1) (HDBM: dibenzoylmethane and DPE: (E)-1,2-di(pyridin-4-yl)ethene), was prepared and identified by elemental analysis, FT-IR, 1H NMR spectroscopy and single-crystal X-ray diffraction. In the 1D linear coordination polymer of 1, the zinc atom has a ZnN2O4 environment with octahedral geometry. These complex units are linked by the bridging of the planar N2 donor DPE ligands. In the coordination network of complex 1, in addition to the hydrogen bonds, the network is more stabilized by π–π stacking interactions between pyridine and β-diketone moieties of the ligands. These interactions increase the ability of the compound to interact with biomacromolecules (BRAF kinase, CatB, DNA gyrase, HDAC7, rHA, RNR, TrxR, TS and Top II) as investigated by docking calculations.
Potential of Rice Husk Ash (RHA) as a Supplementary Cementitious Material in Concrete
Authors: Ahsan Mohammad Badrul , Hossain Zahid 
Published: May 2018

Abstract
Supplementary cementitious material (SCM) is often used to make concrete more durable by improving its mechanistic properties. Rice husk ash (RHA) has the potential of being a SCM because of its pozzolanic activity. Arkansas produces a huge amount of RHA, which mostly originates from the world’s largest rice miller, Riceland Foods, Inc. The RHA produced here is treated as an agricultural waste product and stored in nearby temporary storages, resulting in costly disposal processes as well as environmental hazards. Because the potential of this local RHA as a SCM has not been studied in the past, the present research study aims at exploring the potential of RHA as SCM through laboratory-based experiments. Three different graded RHA (600-RHA, 150-RHA, and 44-RHA) were incorporated in this study. The 600-RHA and 150-RHA were coarse in nature as they had a particle size of 600 μm and 150 μm, respectively, and did not meet the AASHTO M 321-04, Standard Specification for High-Reactivity Pozzolans for Use in Hydraulic-Cement Concrete, Mortar, and Grout, specification. The 600-RHA sample was collected from a plant site and was further ground to produce the 150-RHA sample. The 44-RHA sample was obtained from a commercial industry, and it was incorporated in this study for comparative analyses. Each type of RHA with two different percentages (10 % and 20 %) of replacement of Type I Ordinary Portland Cement (OPC) was investigated in this research. It was found that coarser RHA-modified concrete (600-RHA and 150-RHA) showed reduced strength properties while finer RHA (44-RHA) exhibited improved concrete properties. As a result, 44-RHA can be used as SCM in replacement of the OPC. The coarse RHA could be utilized in backfill and flowable fill as controlled low strength material. Further grinding of the coarse RHA followed by burning may improve the properties of modified concrete.
Research on Connection between Essential Properties and Micromechanism of Organic Silicon–Modified Cement Mortar
Authors: Li Faping , Liu Jiesheng 
Published: May 2018

Abstract
This article aimed to research the effect of organic silicon on the density, mechanical strength, water absorption, porosity, and crack resistance of cementitious construction materials. Modified cement mortar was prepared by adding different amounts of organic silicon into control cement mortar. Mechanical strength was evaluated using bending and compressive strength tests. Porosity was evaluated to assess the inner structure of cement mortar. Furthermore, the micromechanism of modified cement mortar and control cement mortar was explored using the nitrogen-absorption test and a Scanning Electron Microscope (SEM). Experimental results showed that for the organic silicon and mix design used in this article, the incorporation of organic silicon generally reduced the mechanical strength and density and increased the water absorption, porosity, and crack resistance. In addition, the analysis of the nitrogen-absorption test and SEM test revealed the modified mechanism and the connection between the macroscopic properties and micromechanism of modified cement mortar.
Rutting Evaluation of Alaskan Asphalt Pavement Containing Sustainable Materials
Authors: Zhao Sheng , Liu Jenny 
Published: May 2018

Abstract
Permanent pavement deformation, or rutting, is one of the most noticeable distresses in hot mix asphalt. In Alaska, pavement rutting concerns exist at different levels because of seasonal climate change and traffic variation across the entire state. A number of sustainable materials in recent years have been used in Alaska’s pavement construction for their durability and economic and environmental benefits. These materials include modified or highly modified asphalt, warm mix asphalt (WMA), and recycled asphalt pavement (RAP). Using these materials in asphalt pavements may overturn the current understanding of rutting performance in Alaska. Therefore, this study aimed at conducting comprehensive rutting evaluations of these sustainable materials and their applications in Alaska. Based on data collected from 29 Alaskan mixtures, Spearman’s rank correlation coefficient (ρ) was used to discover the link between asphalt pavement analyzer (APA) rut depth and asphalt mixture performance tester parameters for rutting evaluation in order to identify good rutting indicators. The correlation of APA rut depth and flow number (FN) was found to be the strongest, and FN was recommended for rutting evaluation if the APA test was not available. APA results confirmed the good rutting resistance of asphalt mixtures containing high-end modified binders, such as WMA that is produced by adding Sasobit and RAP. Preliminary field evaluation showed no significant rutting concerns in Alaska regarding the application of mixtures containing modified binders, WMA, and RAP.
Cold Compression of 7075 and Factors Influencing Stress Relief
Authors: Robinson J. S. , Wimpory R. C. , Tanner D. A. , Mooney B. , Truman C. E. , Panzner T. 
Published: May 2018

Abstract
The residual stresses in heat-treated 7075 aluminum alloy blocks have been characterized using neutron diffraction, X-ray diffraction, and incremental center-hole drilling. Specimens were quenched to induce high-magnitude residual stresses, which were then stress relieved by the controlled application of plastic deformation using a cold compression technique. The experimental variables investigated were the quench water temperature and the postquench delay. This delay is considered to influence the final residual stress magnitudes because of hardening precipitation occurring by natural aging during the period between quenching and the application of plastic deformation. Cold compression significantly lowered the residual stresses in all specimens. Neutron diffraction measurements demonstrated a benefit to applying plastic deformation as soon as possible after quenching. However, this beneficial effect was not evident when characterizing surface residual stresses using hole drilling or X-ray diffraction.
Circadian Behavioral Responses to Light and Optic Chiasm-Evoked Glutamatergic EPSCs in the Suprachiasmatic Nucleus of ipRGC Conditional vGlut2 Knock-Out Mice
Authors: Moldavan Michael G. , Sollars Patricia J. , Lasarev Michael R. , Allen Charles N. , Pickard Gary E. 
Published: May 2018

AbstractIntrinsically photosensitive retinal ganglion cells (ipRGCs) innervate the hypothalamic suprachiasmatic nucleus (SCN), a circadian oscillator that functions as a biological clock. ipRGCs use vesicular glutamate transporter 2 (vGlut2) to package glutamate into synaptic vesicles and light-evoked resetting of the SCN circadian clock is widely attributed to ipRGC glutamatergic neurotransmission. Pituitary adenylate cyclase-activating polypeptide (PACAP) is also packaged into vesicles in ipRGCs and PACAP may be coreleased with glutamate in the SCN. vGlut2 has been conditionally deleted in ipRGCs in mice [conditional knock-outs (cKOs)] and their aberrant photoentrainment and residual attenuated light responses have been ascribed to ipRGC PACAP release. However, there is no direct evidence that all ipRGC glutamatergic neurotransmission is eliminated in vGlut2 cKOs. Here, we examined two lines of ipRGC vGlut2 cKO mice for SCN-mediated behavioral responses under several lighting conditions and for ipRGC glutamatergic neurotransmission in the SCN. Circadian behavioral responses varied from a very limited response to light to near normal photoentrainment. After collecting behavioral data, hypothalamic slices were prepared and evoked EPSCs (eEPSCs) were recorded from SCN neurons by stimulating the optic chiasm. In cKOs, glutamatergic eEPSCs were recorded and all eEPSC parameters examined (stimulus threshold, amplitude, rise time or time-to-peak and stimulus strength to evoke a maximal response) were similar to controls. We conclude that a variable number but functionally significant percentage of ipRGCs in two vGlut2 cKO mouse lines continue to release glutamate. Thus, the residual SCN-mediated light responses in these cKO mouse lines cannot be attributed solely to ipRGC PACAP release.
Integration of Enhancer-Promoter Interactions with GWAS Summary Results Identifies Novel Schizophrenia-Associated Genes and Pathways
Authors: Wu Chong , Pan Wei 
Published: May 2018

Abstract
It remains challenging to boost statistical power of genome-wide association studies (GWASs) to identify more risk variants or loci that can account for “missing heritability.” Furthermore, since most identified variants are not in gene-coding regions, a biological interpretation of their function is largely lacking. On the other hand, recent biotechnological advances have made it feasible to experimentally measure the three-dimensional organization of the genome, including enhancer–promoter interactions in high resolutions. Due to the well-known critical roles of enhancer–promoter interactions in regulating gene expression programs, such data have been applied to link GWAS risk variants to their putative target genes, gaining insights into underlying biological mechanisms. However, their direct use in GWAS association testing is yet to be exploited. Here we propose integrating enhancer–promoter interactions into GWAS association analysis to both boost statistical power and enhance interpretability. We demonstrate that through an application to two large-scale schizophrenia (SCZ) GWAS summary data sets, the proposed method could identify some novel SCZ-associated genes and pathways (containing no significant SNPs). For example, after the Bonferroni correction, for the larger SCZ data set with 36,989 cases and 113,075 controls, our method applied to the gene body and enhancer regions identified 27 novel genes and 11 novel KEGG pathways to be significant, all missed by the transcriptome-wide association study (TWAS) approach. We conclude that our proposed method is potentially useful and is complementary to TWAS and other standard gene- and pathway-based methods.
HUMAN-ROBOT INTERACTION: LANGUAGE ACQUISITION WITH NEURAL NETWORK
Authors: Fazrie Alvin Rindra 
Published: May 2018

ABSTRACT The paper gives an overview about the process between two language processing methods towards Human-robot interaction. In this paper, Echo State Networks and Stochastic-learning grammar are explored in order to get an idea about generating human’s natural language and the possibilities of integrating these methods to make the communication process between robot to robot or robot to human to be more natural in dialogic syntactic language game. The methods integration could give several benefits such as improving the communicative efficiency and producing the more natural communication sentence. ABSTRAK Tulisan ini memberikan penjabaran mengenai dua metode pemrosesan bahasa alami pada interaksi Manusia dan Robot. Echo State Networks adalah salah satu arsitektur dari Jaringan Syaraf Tiruan yang berdasarkan prinsip Supervised Learning untuk Recurrent Neural Network, dieksplorasi bersama Stochastic-learning Grammar yaitu salah satu framework tata bahasa dengan konsep probabilistik yang bertujuan untuk mendapatkan ide bagaimana proses bahasa alami dari manusia dan kemungkinannya mengintegrasikan dua metode tersebut untuk membuat proses komunikasi antara robot dengan robot atau robot dengan manusia menjadi lebih natural dalam dialogic syntactic language game. Metode integrasi dapat memberikan beberapa keuntungan seperti meningkatkan komunikasi yang efisien dan dapat membuat konstruksi kalimat saat komunikasi menjadi lebih natural. How To Cite : Fazrie, A.R. (2018). HUMAN-ROBOT INTERACTION: LANGUAGE ACQUISITION WITH NEURAL NETWORK. Jurnal Teknik Informatika, 11(1), 75-84. doi 10.15408/jti.v11i1.6093 Permalink/DOI: http://dx.doi.org/10.15408/jti.v11i1.6093
PENGEMBANGAN MIKROKONTROLER SEBAGAI REMOTE CONTROL BERBASIS ANDROID
Authors: Son Mas Sumarsono 
Published: May 2018

ABSTRAK Remote kontrol diciptakan untuk memudahkan komunikasi antar peralatan yang memiliki perangkat penghubung. Alat komunikasi yang dapat dihubungkan adalah perangkat smartphone android yang berkomunikasi dengan alat lain seperti mikrokontroler. Salah satu jenis mikrokontroler adalah ATMega 16 yang dapat diprogram menggunakan bahasa Bascom AVR sehingga dapat mengendalikan perangkat lainnya untuk bergerak yaitu motor servo. Motor servo ini diintegrasikan dengan mikrokontroler dalam menggerakkan media pintu gerbang rumah. Dalam melakukan penelitian ini menggunakan metode eksperimental yaitu mengintegrasikan smartphone android, mikrokontroler ATMega 16, dan prototipe gerbang rumah yang dihubungkan dengan motor servo sebagai penggerak utama gerbang. Dari penelitian yang dilakukan mendapatkan kesimpulan bahwa prototipe ini telah berhasil dirancang dan antar alat dapat berkomunikasi dengan baik sehingga pergerakan pintu gerbang rumah sepenuhnya mampu dikontrol oleh smartphone android. ABSTRACT Remote controls are created to facilitate communication between devices with connecting devices. Communication tools that can be connected are android smartphone devices that communicate with other devices such as microcontrollers. One type of microcontroller is ATMega 16 which can be programmed using Bascom AVR language so it can control other devices to move the servo motor. Servo motor is integrated with the microcontroller in moving the media gate home. In doing this research using experimental method that is integrating android smartphone, microcontroller ATMega 16, and prototype gate home which connected with servo motor as main gate drive. From the research conducted to get the conclusion that the prototype has been successfully designed and inter-tool can communicate well so that the movement of the home gate is fully capable of being controlled by android smartphone. How To Cite : Sumarsono, Saptaningtyas, D.W. (2018). PENGEMBANGAN MIKROKONTROLER SEBAGAI REMOTE CONTROL BERBASIS ANDROID. Jurnal Teknik Informatika, 11(1), 67-74. doi 10.15408/jti.v11i1.6293 Permalink/DOI: http://dx.doi.org/10.15408/jti.v11i1.6293
MANAJEMEN BUKTI DIGITAL HASIL AKUISISI DFXML
Authors: Setyaningsih Putry Wahyu , Prayudi Yudi , Sugiantoro Bambang 
Published: May 2018

ABSTRAK Kasus kejahatan yang banyak terjadi di era modern ini adalah kejahatan di dunia maya yang meninggalkan jejak berupa barang bukti elektronik. Barang bukti elektronik tersebut harus diakuisisi terlebih dahulu untuk menemukan bukti didalamnya dengan mengunakan aplikasi. Salah satu hasil dari akuisisi bukti elektronik adalah berupa DFXML. DFXML adalah pengembangan dari bahasa XML yang dirancang untuk berbagai macam informasi forensik dan hasil pengelolaan forensik. Hasil dari DFXML ini berupa file dengan ekstensi XML, dimana file dengan ekstensi XML ini menghasilkan banyak elemen-elemen dari bukti elektronik yang diakuisisi menjadi bukti digital. Banyaknya elemen-elemen yang dihasilkan oleh XML membuat petugas investigator sulit untuk membacanya. Saat ini masih belum banyak pengembangan yang dilakukan untuk memudahkan petugas investigator untuk membaca elemen-elemen XML hasil akuisisi bukti elektronik menjadi bukti digital yang berupa DFXML. Oleh karena itu dilakukan penelitian dengan melakukan sebuah pengembangan dengan sebuah wadah yang akan mengubah elemen-elemen XML ke dalam sebuah form yang dapat dibaca oleh petugas investigator. ABSTRACTCases of crime that many occur in this modern era is a crime in cyberspace that leaves traces of electronic evidence. Electronic evidence must be obtained first to find evidence in it by using the application. One of the results of electronic evidence acquisition is DFXML. DFXML is an XML language development designed for various forensic information and forensic management results. This DFXML result is a file with an XML extension, where XML files generate many elements from each acquisition result. The number of elements generated by XML makes the investigation officer hard to read. Currently there is not much development done to facilitate the investigator to read the XML elements from the acquisition of electronic evidence into digital evidence in the form of DFXML. Therefore, research is done by developing with a system that will transform the XML element into a form that can be read by the investigator. How To Cite : Setyaningsih, P.W. Prayudi, Y. Sugiantoro, B (2018). MANAJEMEN BUKTI DIGITAL HASIL AKUISISI DFXML. Jurnal Teknik Informatika, 11(1), 47-54. doi 10.15408/jti.v11i1.6680 Permalink/DOI: http://dx.doi.org/10.15408/jti.v11i1.6680
Interferon-γ Release Assay Performance for Tuberculosis in Childhood
Authors: Kay Alexander W. , Islam Shamim M. , Wendorf Kristen , Westenhouse Janice , Barry Pennan M. 
Published: May 2018

BACKGROUND:
Interferon-γ release assays (IGRAs) are important adjunctive tests for diagnosing tuberculosis (TB) disease in children.

METHODS:
We analyzed California TB registry data for patients ≤18 years with laboratory-confirmed TB disease during 2010–2015 to identify case characteristics associated with test selection and performance and measure IGRA sensitivity.

RESULTS:
In total, 778 cases of TB were reported; 360 were laboratory confirmed. Indeterminate IGRAs were associated with being &lt;1 year old (prevalence rate ratio 9.23; 95% confidence interval 2.87 to 29.8) and having central nervous system disease (prevalence rate ratio 2.69; 95% confidence interval 1.06 to 6.86) on multivariable analysis. Ninety-five children had both an IGRA and tuberculin skin test (TST) performed. Among those, the sensitivity of IGRA in 5- to 18-year-olds was 96% (66 out of 69) vs 83% (57 out of 69) for TST (P = .01); IGRA sensitivity compared with TST in children ages 2 to 4 was 91% (10 out of 11) vs 91% (10 out of 11) (P &gt; .99), and the sensitivity compared with TST in children aged &lt;2 years was 80% (12 out of 15) vs 87% (13 out of 15) (P &gt; .99).

CONCLUSIONS:
This is the largest North American analysis of IGRA use and performance among children with TB disease. In children &lt;5 years old, IGRA sensitivity is similar to TST, but sensitivity of both tests are reduced in children &lt;2 years old. Indeterminate results are higher in children &lt;1 year old and in central nervous system disease. In children ≥5 years old with laboratory-confirmed TB, IGRA has greater sensitivity than TST and should be considered the preferred immunodiagnostic test..
Optimasi Proses Produksi Hidrolisat Protein Ikan (Hpi) dari Mujair ( Oreochromis Mossambicus ).
Authors: Ariyani Farida , M. Saleh. M. Saleh. , Tazwir Tazwir , Hak. Nurul 
Published: May 2018

Salah satu upaya untuk meningkatkan nilai tambah ikan bernilai ekonomis rendah adalah dengan memanfaatkannya menjadi hidrolisat protein ikan (HPI). Untuk itu telah dipelajari proses pembuatan HPI dari bahan baku ikan mujair (Oreochromis mossambicus) secara enzimatis. Pada penelitian ini proses hidrolisis dilakukan dengan menambahkan enzim papain kasar (PAYA) yang diperoleh dari pasar lokal ke dalam ikan mujair cacahan dengan konsentrasi 6, 8 dan 10% (b/b). Untuk mempercepat proses hidrolisis, ke dalam campuran ikan dan enzim ditambahkan akuades sebanyak 25% ( b/b ). Inkubasi ilakukan secara aerobik pada suhu 55-­60 derajad Celcius. Pengambilan sampel dilakukan setelah 6 jam, 12 jam, 24 jam, 36 jam, 48 jam, kemudian setiap hari sampai 10 hari lama inkubasi. Analisis dilakukan terhadap produk HPI yang meliputi tingkat pencairan serta rasio antara a‑amino nitrogen dengan total nitrogen dan analisis organoleptik. Hasil percobaan menunjukkan bahwa hidrolisat protein dapat diproduksi dari ikan mujair dengan enzim papain produksi lokal sebanyak 10%, dengan lama hidrolisis 4 hari. Dalam bentuk cair, hidrolisat protein ikan mujair berwarna kuning kecoklatan, berasa gurih, agak manis dan mengandung asam amino yang tidak jauh berbeda dengan kecap ikan maupun sari pati ayam.
Predictors of Location of Death for Children with Cancer Enrolled on a Palliative Care Service
Authors: Kaye Erica C. , DeMarsh Samantha , Gushue Courtney A. , Jerkins Jonathan , Sykes April , Lu Zhaohua , Snaman Jennifer M. , Blazin Lindsay J. , Johnson Liza-Marie , Levine Deena R. , Morrison R. Ray , Baker Justin N. 
Published: May 2018

Abstract

Background
In the U.S., more children die from cancer than from any other disease, and more than one third die in the hospital setting. These data have been replicated even in subpopulations of children with cancer enrolled on a palliative care service. Children with cancer who die in high-acuity inpatient settings often experience suffering at the end of life, with increased psychosocial morbidities seen in their bereaved parents. Strategies to preemptively identify children with cancer who are more likely to die in high-acuity inpatient settings have not been explored.

Materials and Methods
A standardized tool was used to gather demographic, disease, treatment, and end-of-life variables for 321 pediatric palliative oncology (PPO) patients treated at an academic pediatric cancer center who died between 2011 and 2015. Multinomial logistic regression was used to predict patient subgroups at increased risk for pediatric intensive care unit (PICU) death.

Results
Higher odds of dying in the PICU were found in patients with Hispanic ethnicity (odds ratio [OR], 4.02; p = .002), hematologic malignancy (OR, 7.42; p &lt; .0001), history of hematopoietic stem cell transplant (OR, 4.52; p &lt; .0001), total number of PICU hospitalizations (OR, 1.98; p &lt; .0001), receipt of cancer-directed therapy during the last month of life (OR, 2.96; p = .002), and palliative care involvement occurring less than 30 days before death (OR, 4.7; p &lt; .0001). Conversely, lower odds of dying in the PICU were found in patients with hospice involvement (OR, 0.02; p &lt; .0001) and documentation of advance directives at the time of death (OR, 0.37; p = .033).

Conclusion
Certain variables may predict PICU death for PPO patients, including delayed palliative care involvement. Preemptive identification of patients at risk for PICU death affords opportunities to study the effects of earlier palliative care integration and increased discussions around preferred location of death on end-of-life outcomes for children with cancer and their families.

Implications for Practice
Children with cancer who die in high-acuity inpatient settings often experience a high burden of intensive therapy at the end of life. Strategies to identify patients at higher risk of dying in the pediatric intensive care unit (PICU) have not been explored previously. This study finds that certain variables may predict PICU death for pediatric palliative oncology patients, including delayed palliative care involvement. Preemptive identification of patients at risk for PICU death affords opportunities to study the effects of earlier palliative care integration and increased discussions around preferred location of death on end-of-life outcomes for children with cancer and their families.