bluuebunny/crossref_metadata_2025_split huggingface dataset:
Icariin-conditioned serum engineered with hyaluronic acid promote repair of articular cartilage defects in rabbit knees
Authors: Zhang Juntao , Zhang Donglin , Wu Chaochao , Liu Aifeng , Zhang Chao , Jiao Jianjie , Shang Man 
Published: July 2019

Abstract
Background
Osteochondral defects mostly occur as a result of trauma or articular degeneration. The poor regenerative ability of articular cartilage remains osteochondral defects are a tricky problem to deal with. The modern treatment strategies mainly focus on cartilage tissue engineering with bioactive materials. In this study, we aimed to develop icariin conditioned serum (ICS) together with hyaluronic acid (HA) and determine their ability in reparing osteochondral tissue in a critical-sized defect in rabbit knees.

Methods
Primary chondrocytes were incubated with serum conditioned with icariin at different concentrations, then cell proliferation rates and glycosaminoglycan (GAG) secretion were detected. Rabbits were treated with intra-articular injection of 0.5 mL normal saline (NS), ICS, HA and ICS + HA in the right knee joint, respectively. ICRS scores were used to assess the macroscopic cartilage regeneration. Histological and immunohistochemical analysis including H&E, Safranin O, toluidine blue and collagen II staining were used to determine the repair of cartilage and the regeneration of chondrocytes.

Results
Icariin at a low dose of 0.94 g/kg was identified to have significantly promoted the proliferation of chondrocytes and enhance the secretion of GAG. Femoral condyle from rabbits treated by ICS together with HA was observed to be integrated with native cartilage and more subchondral bone regeneration. ICS together with HA could promote repair of the cartilage defect and increase the neoformation of cartilage.

Conclusions
These results demonstrated the potential of ICS combined with HA to promote reparative response in cartilage defects and the possible application in bioactive material based cartilage regeneration therapies.
The impact of multimorbidity on foot health outcomes in podiatry patients with musculoskeletal foot pain: a prospective observational study
Authors: Hendry Gordon J. , Fenocchi Linda , Mason Helen , Steultjens Martijn 
Published: July 2019

AbstractBackgroundMultimorbidity is prevalent and adversely affects health outcomes. Foot pain is common and one of the primary reasons for utilisation of podiatry services. At present, little is known about the impact of multimorbidity on foot health and related outcomes following podiatric intervention. The aims of this study were to evaluate whether there is a difference in foot health outcomes following exposure to podiatric foot care for people with and without multimorbidity; and ii) to evaluate whether the presence or absence of multimorbidity affects patients' perceptions of change in foot pain.MethodsThe PROMFoot study is a prospective cohort study of adults with a new episode of foot pain attending the podiatry service within the NHS Greater Glasgow and Clyde health board. Baseline medical comorbidity status (no condition, single condition, multiple conditions), longitudinal data on foot health measured using the Foot Health Status Questionnaire (FHSQ), and patient rating of change scores for foot pain were obtained from the PROMFoot study at baseline, and 3 and 6 months after podiatric intervention. Foot health scores (pain, function, footwear and general foot health) and perceptions of change for foot pain were compared between comorbidity groups.ResultsA total of 115 participants (59% female) with a mean age of 55 years were included. Multimorbidity was common, affecting 61 participants (53%); while 28 (24.3%) and 26 (22.6%) reported single or no medical comorbidities respectively. Significantly worse foot health scores for all FHSQ domains were observed for the multimorbidity group at baseline, 3 and 6 months. Change scores for foot pain were similar between groups and demonstrate modest improvements, however multimorbidity group membership was strongly associated with a perceptions of change in foot pain. Multimorbidity was independently associated with poorer foot function outcomes at 3 months, and poorer foot pain and foot function outcomes at 6 months.ConclusionsMultimorbidity was associated with poor foot health outcomes and lower rates of self‐perceived improvement in foot pain over 6 months following podiatric intervention in a sample of patients attending podiatric biomechanics clinics for a new episode of foot pain.
Incidence and Management of Olaratumab Infusion-Related Reactions
Authors: Van Tine Brian A. , Govindarajan Rangaswamy , Attia Steven , Somaiah Neeta , Barker Scott S. , Shahir Ashwin , Barrett Emily , Lee Pablo , Wacheck Volker , Ramage Samuel C. , Tap William D. 
Published: July 2019

PURPOSE:Olaratumab is a human monoclonal immunoglobulin G1 antibody against platelet-derived growth factor receptor-α. We report the nature and frequency of infusion-related reactions (IRRs) with olaratumab in clinical trials and postmarketing reports.METHODS:Data from patients exposed to olaratumab across nine clinical trials were reviewed for IRRs. Blood samples were also analyzed for pre-existing immunoglobulin E anti–galactose-α-1,3-galactose (anti–α-Gal) antibodies.RESULTS:In the clinical trials, IRRs were identified in 70 of 485 patients (14.4%). The most frequent symptoms included flushing, fever or chills, and dyspnea. For 68 of 70 patients (97.1%), the first IRR occurred during the first two cycles of treatment. Grade 3 or worse IRRs were reported in 11 patients (2.3%), all during the first infusion and usually within 15 minutes of the start of the infusion. One IRR-related fatality (0.2%) occurred in a nonpremedicated patient with grade 3 or worse cardiac comorbidities. There was an association between grade 3 or worse IRRs and pre-existing anti–α-Gal antibodies, with a trend toward higher IRR rates in US geographies known to have a higher prevalence of anti–α-Gal antibodies. IRRs in postmarketing reports were consistent in nature and severity with those in the clinical trials.CONCLUSION:Premedication with corticosteroids and antihistamines should occur in all patients before olaratumab infusion, as indicated in labels in the United States and the European Union. Patients receiving olaratumab should be monitored for IRRs in a setting where resuscitation equipment is available for the treatment of IRRs.
Professional capacity building of Health Science Journal Editors
Authors: Jawaid Shaukat Ali , Jawaid Masood 
Published: July 2019

doi: https://doi.org/10.12669/pjms.35.4.1299
How to cite this:Jawaid SA, Jawaid M. Professional capacity building of Health Science Journal Editors. Pak J Med Sci. 2019;35(4):879-881. doi: https://doi.org/10.12669/pjms.35.4.1299
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Η διαθεματικότητα των αναλυτικών προγραμμάτων στην προσχολική και πρώτη σχολική ηλικία στην Ελλάδα και στο Ηνωμένο Βασίλειο
Authors: Μάνεση (Soultana Manesi) Σουλτάνα 
Published: July 2019

Κεντρικό σημείο της παρούσας εργασίας είναι η επιτακτική ανάγκη να θεωρήσουμε τα παιδιά ως οντότητες, των οποίων τα ενδιαφέροντα, οι επιθυμίες και τα δικαιώματα οφείλουν να λαμβάνονται σοβαρά υπόψη κατά τη διαμόρφωση εκπαιδευτικών προγραμμάτων. Εκκινώντας από αυτήν την παραδοχή, η εφαρμογή ενός καινοτομικού, διαθεματικού αναλυτικού προγράμματος θεωρείται ως απαραίτητη προϋπόθεση για κάθε εκπαιδευτικό σύστημα στο σύγχρονο παγκοσμιοποιημένο περιβάλλον. Υπό αυτό το θεωρητικό πλαίσιο, η εργασία αυτή επιχειρεί να μελετήσει συγκριτικά τη διαθεματικότητα των αναλυτικών προγραμμάτων στην προσχολική και πρώτη σχολική ηλικία, στην Ελλάδα και το Ηνωμένο Βασίλειο. Εφαλτήριο του ενδιαφέροντός μου για τη συγκεκριμένη εργασία υπήρξε ο προσωπικός μουαναστοχασμός σχετικά με την ανάγκη να εμπλέξουμε τα παιδιά με ενεργό τρόπο και ολιστικά στη διαδικασία μάθησής τους.
Option-Implied Intrahorizon Value at Risk
Authors: Leippold Markus , Vasiljević Nikola 
Published: July 2019

In this paper, we theoretically and empirically study the intrahorizon value at risk (iVaR) in a general jump-diffusion setting. We propose a new class of models of asset returns, the displaced mixed exponential model, which can arbitrarily closely approximate finite and infinite activity Lévy processes. We then derive analytical results for the iVaR and disentangle, in a theoretically consistent way, the jump and diffusion contributions to the intrahorizon risk. We estimate historical and option-implied value at risk and iVaR for several popular jump models using the Standard & Poor’s (S&P) 100 Index and American options. Empirically disentangling the contribution of the jumps from the contribution of the diffusion, we conclude that jumps account for about 90% of the iVaR on average. Our back-testing results indicate that the option-implied estimates are much more responsive to market changes than their historical counterparts, which perform poorly. This paper was accepted by Gustavo Manso, finance.
Проблемные аспекты развития социальной политики Алтайского края в 1990-1995 гг.
Authors: Радонова Анна Владимировна 
Published: July 2019

Раскрываются современные подходы к определению социальной политики государства. Характеризуются ее основные цели, приоритеты, раскрывается сущность способов достижения поставленных задач и перспективы последствий их реализации в 1990-1995 гг. Целью исследования является характеристика эволюции социальной политики Алтайского края в первой половине 90-х гг.
ХХ в. Историографический обзор проведен по трем направлениям исследования: защита слабообеспеченных слоев народонаселения; переработка принципов финансирования социосферы; регулирование рынка труда и трансформация политики занятости.
На примере Алтайского края характеризуются проблемы и достижения региональной политики в области социальной поддержки народонаселения; определяются основные направления усовершенствования сложившейся ситуации на ближайшие десятилетия XXI в. Авторские выводы подтверждаются статистическими показателями вложений в социальную сферу Алтайского края конца XX в.
Научная новизна исследования заключается во введении в научный оборот ряда архивных документов, регулирующих социальную политику Алтайского края в 1990-1995 гг., а также в анализе формальных институтов региональной социальной политики Алтайского края, который доказывает, что в ходе институциональных трансформаций в регионе сложилась либеральная модель социальной политики, соответствующая местным экономическим возможностям и политическим установкам элиты. Обобщены сведения о структуре органов управления в области социальной защиты народонаселения Алтайского региона в постсоветский период. Приводится анализ нормативных актов, регламентирующих их деятельность, основные полномочия и выполняемые функции.
Кроме того, анализируются этапы реформирования системы управления социальной защиты населения и причины трудностей, возникающих в этой связи. Раскрываются цели и порядок реформирования системы органов социальной защиты на всей территории Алтайского края.
Psychobiotics: Shaping the Mind With Gut Bacteria
Authors: Jacobs Jonathan P. , Mayer Emeran A. 
Published: July 2019

Abstract
Preclinical and a few clinical studies have demonstrated the existence of a brain-gut-microbiome axis in which bacterial signals can modulate affective behavior, brain activity, and central gene expression profiles. The study by Wang et al. in this issue (Wang H, Braun C, Murphy EF, et al. Bifidobacterium longum 1714™ strain modulates brain activity of healthy volunteers during social stress. Am J Gastroenterol 2019;114:1152–62.) contributes to a growing body of literature demonstrating that probiotics that alter behavior in animal models—termed “psychobiotics”—can induce changes in human brain networks involved in emotional or cognitive responses. Although there are still many unknowns about the potential of existing probiotics to induce clinically relevant effects, these findings support continued investigation into interventions acting on the brain-gut-microbiome axis for affective, cognitive, and behavioral disorders.
ANTIOXIDANT ACTIVITY OF THE AERIAL PARTS AND THE FLOWERS OF CHILIOTRICHUM DIFFUSUM (G. FORST.) KUNTZE (ASTERACEAE), A MEDICINAL PLANT USED BY THE ONAS
Authors: Alcalde Bahamonde Sandra Marcela , Taira Carlos Alberto , Flores María Luján , Córdoba Osvaldo León 
Published: July 2019

The antioxidant capacity of Chiliotrichum diffusum, a medicinal plant used in the traditional medicine of the Onas (original people of Patagonia), was studied by using the DPPH method, to explain the properties associated to the traditional use of this species. Ethyl ether (or dichloromethane from decoction of the flowers) and the ethyl acetate fraction from ethanol and aqueous extracts, showed free radical scavenging capacity on DPPH•. The results of the quantitative determination of this activity in ethyl ether and the ethyl acetate fraction from ethanol extract of aerial parts showed SC50 of 5.2 and 3.5 μg/mL, respectively. Dichloromethane and ethyl acetate fractions of the aqueous extracts from flowers showed SC50 values of 35.0 and 9.5 μg/mL. The principal flavonoids found were kaempferol, quercetin and their derivates. These results showed a relation of the phenols evidenced in the aerial parts and flowers and the antioxidant activity; also explained, at least partially, the medicinal properties described, and the use of this plant in the traditional medicine of the Onas.
ESTRUTURAÇÃO DE UM SERVIÇO DE INFORMAÇÕES SOBRE MEDICAMENTOS (SIM) EM UM HOSPITAL DO RIO GRANDE DO NORTE, BRAZIL
Authors: Nascimento Martins Álex Brunno , Mariz Batista Almária 
Published: July 2019

Centros/Serviços de Informações sobre Medicamentos são importantes e úteis, pois contribuem para o uso racional de medicamentos. O objetivo deste estudo foi avaliar as informações prestadas pelo Serviço de Informações sobre Medicamentos do Hospital Regional Dr. Mariano Coelho em Currais Novos, RN. Para tanto, foi realizado um estudo observacional a partir do banco de dados do Serviço, cujas solicitações de informação foram recebidas entre abril de 2017 e novembro de 2018. As informações foram avaliadas a partir de média mensal de solicitações de informação, temas das perguntas, meio pelo qual foi recebida, perfil do solicitante, fontes de informação utilizadas e classificação farmacológica dos medicamentos envolvidos. Durante o período, foram recebidas 31 solicitações (1,6 solicitações/mês), a maioria tinha como tema a indicação de uso de medicamentos (22,6%) e foi solicitada pessoalmente (71,0%) por residentes multiprofissionais (45,2%). Bases de dados eletrônicas foram as fontes de informações mais utilizadas para responder às solicitações (40,0%); e os antibióticos de uso sistêmico os medicamentos mais presentes nas solicitações (23,7%). Depreende-se que este Serviço foi potencialmente útil para se evitar uso irracional de medicamentos. Em relação ao perfil de solicitações de outros centros/serviços, este apresentou perfil pouco semelhante aos demais.
KOMBUCHA: EFEITOS IN VITRO E IN VIVO
Authors: Guimarães Medeiros Stéphany Christine , Cechinel-Zanchett Camile Cecconi 
Published: July 2019

A busca por um estilo de vida mais saudável tem levado as pessoas a procurarem e escolherem produtos mais saudáveis. O kombucha é um probiótico, consumido no mundo todo, como uma bebida caseira refrescante, sendo também comercializada por algumas empresas. Esse trabalho avaliou o kombucha, relacionando composição, efeitos benéficos e aspectos toxicológicos causados por seu consumo. Foi realizada uma revisão crítica da literatura, baseada em artigos científicos, livros e documentos oficiais, nas bases de dados de artigos científicos: SciELO, Lilacs, Medline, e Science Direct, nos idiomas português, inglês e espanhol publicados entre 2014 e 2018, onde foi utilizado o descritor “kombucha”. A busca bibliográfica foi feita sem restrição de população e tema para não limitar o número de artigos. Os estudos apontaram prováveis benefícios relacionados à composição química do kombucha. Os benefícios relatados foram: atividade antioxidante, antibacteriana, antifúngica, efeito probiótico, potencial anticarcinogênico, efeito hipoglicemiante, além de outros efeitos terapêuticos e de prevenção de doenças crônicas não transmissíveis. Poucas pesquisas foram feitas com humanos para avaliar com mais precisão seus benefícios, toxicidade, e usos terapêuticos. Portanto, mais estudos devem ser realizados, com o intuito de identificar os metabólitos produzidos, entender sua relação com as atividades biológicas, assim como sua aplicação em humanos.
ASSISTÊNCIA FARMACÊUTICA NA ATENÇÃO PRIMÁRIA À SAÚDE DE UM MUNICÍPIO POTIGUAR, BRASIL
Authors: Nóbrega Bernardino Caroline , Mariz Batista Almária 
Published: July 2019

Este estudo teve como objetivo avaliar a Assistência Farmacêutica no município de Caicó, RN, Brasil, com base em indicadores, via estudo transversal e descritivo realizado de setembro de 2016 a março de 2017, a partir de 10 indicadores aplicados à Central de Abastecimento Farmacêutico e 30 aplicados nas 23 farmácias das Unidades Básicas de Saúde. O município possui Relação Municipal de Medicamentos Essenciais, mas não conta com Comissão de Farmácia e Terapêutica. Nenhuma das farmácias apresentava farmacêutico lotado, procedimento operacional padrão e registros de movimentação de estoque. A entrega de medicamentos nestas farmácias era realizada por agentes comunitários de saúde (35%), enfermeiros (74%) e técnicos de enfermagem (100%). Apenas 65% das farmácias possuía ar condicionado e nenhuma delas apresentava mapa de controle de umidade e temperatura. Os dados revelam que a assistência farmacêutica do município de Caicó é ainda incipiente e pressupõe maior responsabilidade e compromisso dos gestores municipais para cumprir com sua efetividade.
Die Sammlung ist tot, es lebe die Sammlung!
Authors: Stäcker Thomas 
Published: July 2019

ZusammenfassungMit dem digitalen Wandel verändert sich der überlieferte Begriff der Sammlung. Während früher Bibliotheken ihre Bedeutung aus der Größe und Qualität ihrer Sammlung ableiteten, sind sie heute angesichts der zunehmend frei verfügbaren digitalen Quellen und Dokumente gezwungen umzudenken. Der Beitrag vertritt die Position, dass die Kultur des Besitzens einer Kultur des Teilens weichen muss. Nicht der exklusive Besitz eines Mediums entscheidet über die Qualität einer Bibliothek, sondern der nicht-exklusive Besitz. Dokumente und Daten werden aus der Logik des Mediums heraus in Zukunft durchgehend im Open Access angeboten werden. Das bedeutet aber nicht, dass sich das Sammeln erübrigte. Die Inadäquatheit, Disparität und Inhomogenität der analogen oder freien digitalen Angebote verlangt nach Transformation, Aggregation und Strukturierung bzw. Homogenisierung der Dokumente und Daten, um über die Herstellung der Maschinenlesbarkeit nach den FAIR Prinzipien attraktive Angebote von qualitativ hochwertigen digitalen Daten- und Dokumentsammlungen und Korpora für die mit digitalen Methoden arbeitende Forschung machen zu können. Für die Bibliothek eröffnen sich unter dem Begriff der Datafication wichtige neue Arbeitsfelder, die zwar die alte Sammlung obsolet machen, aber sie eine neue gewinnen lassen.
Alternative Enriched Test Spaces in the DPG Method for Singular Perturbation Problems
Authors: Salazar Jacob , Mora Jaime , Demkowicz Leszek 
Published: July 2019

Abstract
We propose and investigate the application of alternative enriched test spaces in the discontinuous Petrov–Galerkin (DPG) finite element framework for singular perturbation linear problems, with an emphasis on 2D convection-dominated diffusion. Providing robust

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2

{L^{2}}

error estimates for the field variables is considered a convenient feature for this class of problems, since this norm would not account for the large gradients present in boundary layers. With this requirement in mind, Demkowicz and others have previously formulated special test norms, which through DPG deliver the desired

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{L^{2}}

convergence. However, robustness has only been verified through numerical experiments for tailored test norms which are problem-specific, whereas the quasi-optimal test norm (not problem specific) has failed such tests due to the difficulty to resolve the optimal test functions sought in the DPG technology. To address this issue (i.e. improve optimal test functions resolution for the quasi-optimal test norm), we propose to discretize the local test spaces with functions that depend on the perturbation parameter ϵ. Explicitly, we work with B-spline spaces defined on an ϵ-dependent Shishkin submesh. Two examples are run using adaptive h-refinement to compare the performance of proposed test spaces with that of standard test spaces. We also include a modified norm and a continuation strategy aiming to improve time performance and briefly experiment with these ideas.
Effect of resins on the salt spray resistance and wet adhesion of two component waterborne polyurethane coating
Authors: Xu Qianwei , Lu Qingli , Zhu Steven , Pang Robin , Shan Wanwen 
Published: July 2019

AbstractEffects of the type, chemical structure and NCO/OH of resins on wet adhesion and salt spray resistance of two component waterborne polyurethane coating were studied in this paper. The content of functional groups in resins and films were analysed by areas of their FT-IR absorption peak to study the relationship with anticorrosive performance of coatings. Coatings based on resins with more -OH tend to have stronger wet adhesion and salt spray resistance because resins with more -OH have more possibilities to react with -NCO to form a compact film with a higher crosslinking degree. The wet adhesion of coatings after 8 h of immersion deteriorated from level 1 to level 5 with the increase of NCO/OH due to the decrease of -OH in coatings to link with substrates. And excess -NCO tend to react with H2O to generate CO2 to form cracked physical bubbles, which would weaken the wet adhesion.
A Novel Method for High Frequency-Resolution Group Delay Acquisition Based on Tikhonov Regularization
Authors: Luo Rui , Pen Tianyu , Wang Shu-Na , Li Lingyun 
Published: July 2019

Abstract
The differential method is extensively adopted in the group delay measurement, where a contradiction between frequency-resolution and precision is present owning to the phase measurement error. This paper proposes a novel method for group delay calculating based on improved Tikhonov regularization that can omit the difference procedure. The comparative analysis demonstrates that the new method is capable of obtaining more precise group delay value along with high frequency-resolution when the measurement error of phase is included.
Performance Analysis of 80 GHz-Millimeter Wave Radio over Dispersive Fiber
Authors: Goel Pooja , Kaushik Rahul 
Published: July 2019

Abstract
The generation of 80 GHz millimeter wave (mm-wave) signal and its transmission over single mode fiber (SMF) is presented. The mm-wave signal is generated with dual parallel dual drive Mach Zehnder modulators using frequency quadrupling of 20 GHz radio frequency signal. Transmission of generated mm-wave signal over SMF has been investigated. The impact of varying modulation depth on optical side band suppression ratio and radio frequency spurious suppression ratio for different extinction ratios (ER) is studied. Further, the impact of dispersion, on received power is also analyzed. Error analysis between analytical and simulation results is carried out. It has been observed, that increasing ER leads to reduction in both peak error and mean error and the received power is reduced under the combined effect of second and third order dispersion at very high modulation depth.