bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual Periacetabular Osteotomy and Anatomical Measurements
Authors: Xu Gang , Dong Chao , Zdzislaw Krol , Krieg Andreas H 
Published: March 2019

ObjectiveTo report on a CT scan virtual periacetabular osteotomy (PAO) process to evaluate the potential risk of different PAO cutting planes.MethodsA total of 123 patients (64 men and 59 women) underwent virtual PAO. We defined two retroacetabular cutting (RC) planes: the RC plane and the RC+ plane (10 mm posteriorly as compared to the RC plane). Subsequently, we measured the anatomical minimum distance between the acetabulum and the sciatic notch, the minimum distance between the acetabulum and the retroacetabular cutting plane (osteotomy of the posterior column), and the osteotomy length in the cranio‐caudal direction.ResultsThe mean (standard deviation [SD]) minimum distance between the acetabulum and the sciatic notch was 25.82 ± 3.52 mm (95% confidence intervals [CI], 25.36–26.25 mm). In men, the mean (SD) minimum distance between the acetabulum and sciatic notch (27.18 ± 3.47 mm; 95% CI, 26.56–27.78 mm) was significantly (3 mm) larger than in women (24.34 ± 2.92 mm; 95% CI, 23.82–24.89 mm; P < 0.001).The mean (SD) minimum distance between the acetabulum and the retroacetabular plane was significantly larger for the RC+ plane (6.97 ± 0.91 mm) than for the RC plane (P < 0.001). In men, this distance (10.23 ± 3.84 mm) was significantly (2.3 mm) larger than in women (7.94 ± 3.45 mm; P < 0.001).The mean (SD) osteotomy length was significantly larger for the RC+ plane (61.78 ± 6.75 mm) than for the RC plane (68.48 ± 6.65) mm; P < 0.001). All three evaluated parameters had significantly shorter lengths in women than in men.ConclusionThe safety space for PAO in women was narrower than in men. By shifting the RC plane 10 mm into the posterior direction, the RC+ plane provides a safer cutting distance and shorter osteotomy line in the PAO than the RC plan, which is important to avoid intraarticular penetration.
Covariate-Assisted Ranking and Screening for Large-Scale Two-Sample Inference
Authors: Tony Cai T. , Sun Wenguang , Wang Weinan 
Published: March 2019

SummaryTwo-sample multiple testing has a wide range of applications. The conventional practice first reduces the original observations to a vector of p-values and then chooses a cut-off to adjust for multiplicity. However, this data reduction step could cause significant loss of information and thus lead to suboptimal testing procedures. We introduce a new framework for two-sample multiple testing by incorporating a carefully constructed auxiliary variable in inference to improve the power. A data-driven multiple-testing procedure is developed by employing a covariate-assisted ranking and screening (CARS) approach that optimally combines the information from both the primary and the auxiliary variables. The proposed CARS procedure is shown to be asymptotically valid and optimal for false discovery rate control. The procedure is implemented in the R package CARS. Numerical results confirm the effectiveness of CARS in false discovery rate control and show that it achieves substantial power gain over existing methods. CARS is also illustrated through an application to the analysis of a satellite imaging data set for supernova detection.
Zolpidem Use and Suicide Death in South Korea: A Population‐Based Case–Control Study
Authors: Choi BongKyoo , Sung Hi Gin , Nam Jin Hyun , Shin Ju‐Young 
Published: March 2019

ObjectiveTo investigate whether zolpidem use is associated with suicide death in adults.MethodWe conducted a case–control study using the National Health Insurance Service‐National Sample Cohort (NHIS‐NSC) database. Cases were adults with a suicide record (ICD‐10 codes; X‐60‐X84, Y87.0) between January 1, 2004 and December 31, 2013. 10 Controls were matched to each case by age, sex, index year, region, income level, and health insurance type. Zolpidem use during 2 years before suicide was quantified. Adjusted odd ratios (aORs) with 95% confidence intervals (CIs) were estimated using conditional logistic regression.ResultsThe percentage of zolpidem users was significantly higher in cases (451 of 1,928 [23.4%]) than in controls (832 of 18,404 [4.5%]). After controlling for potential confounders, zolpidem use was significantly associated with suicide (aORs, 2.09; 95% CI, 1.74–2.52). Dose–response relationships were observed (for trend, p < .0001). Consistent findings were observed when analyses were restricted to suicide death (aORs, 2.08; 95% CI, 1.73–2.51) and nonmedication poisoning suicide death cases (aORs, 2.10; 95% CI, 1.74–2.53).ConclusionsWe found a significant and positive association between zolpidem use and suicide. Zolpidem should be prescribed cautiously and with due caution of increased suicide risk.
Sports participation is inversely associated with C‐reactive protein levels in adolescents: ABCD Growth Study
Authors: Cayres Suziane Ungari , Werneck André Oliveira , Urban Jacqueline Bexiga , Turi‐Lynch Bruna Camilo , Barbosa Maurício Fregonesi , Fernandes Romulo Araújo 
Published: March 2019

ObjectiveTo analyze the relationship between sports participation and C‐reactive protein (CRP) levels in adolescents and to identify the possible role of mediation developed by trunk fatness (TF).MethodsCross‐sectional design, part of the longitudinal study entitled “Analysis of Behaviors of Children During Growth” (ABCD Growth Study), Presidente Prudente, SP, Brazil. The sample comprised 259 adolescents (14.7 ± 2.1 [182 boys and 77 girls]) stratified according to sex and engagement in sports in agreement with the inclusion criteria: absence of any known diseases; previous engagement in sports for at least 12 months (≥300 minutes weekly); no regular engagement in sports in the previous 12 months (non‐regular sports participation or <300 min/wk); written parental consent and adolescents' assent both signed. Engagement in sports was self‐reported. CRP levels were used to assess the inflammatory status. TF was estimated by a densitometer scanner. Age, biological maturation, HOMA‐IR, and blood pressure were treated as covariates.ResultsThere was no mediation effect of TF in the association of any indicators of sports practice and CRP. However, a direct effect of sports was observed on CRP levels when considering previous months of engagement, frequency, and volume of sports for boys and also previous months of engagement in sports for girls.ConclusionPrevious sports participation and the amount of engagement in sports per week (≥300 min/wk) presented an inverse relationship with CRP levels; however, trunk fatness did not mediate this process.
The Arabidopsis heterotrimeric G‐protein β subunit, AGB1, is required for guard cell calcium sensing and calcium‐induced calcium release
Authors: Jeon Byeong Wook , Acharya Biswa R. , Assmann Sarah M. 
Published: March 2019

Summary
Cytosolic calcium concentration ([Ca2+]cyt) and heterotrimeric G‐proteins are universal eukaryotic signaling elements. In plant guard cells, extracellular calcium (Cao) is as strong a stimulus for stomatal closure as the phytohormone abscisic acid (ABA), but underlying mechanisms remain elusive. Here, we report that the sole Arabidopsis heterotrimeric Gβ subunit, AGB1, is required for four guard cell Cao responses: induction of stomatal closure; inhibition of stomatal opening; [Ca2+]cyt oscillation; and inositol 1,4,5‐trisphosphate (InsP3) production. Stomata in wild‐type Arabidopsis (Col) and in mutants of the canonical Gα subunit, GPA1, showed inhibition of stomatal opening and promotion of stomatal closure by Cao. By contrast, stomatal movements of agb1 mutants and agb1/gpa1 double‐mutants, as well as those of the agg1agg2 Gγ double‐mutant, were insensitive to Cao. These behaviors contrast with ABA‐regulated stomatal movements, which involve GPA1 and AGB1/AGG3 dimers, illustrating differential partitioning of G‐protein subunits among stimuli with similar ultimate impacts, which may facilitate stimulus‐specific encoding. AGB1 knockouts retained reactive oxygen species and NO production, but lost YC3.6‐detected [Ca2+]cyt oscillations in response to Cao, initiating only a single [Ca2+]cyt spike. Experimentally imposed [Ca2+]cyt oscillations restored stomatal closure in agb1. Yeast two‐hybrid and bimolecular complementation fluorescence experiments revealed that AGB1 interacts with phospholipase Cs (PLCs), and Cao induced InsP3 production in Col but not in agb1. In sum, G‐protein signaling via AGB1/AGG1/AGG2 is essential for Cao‐regulation of stomatal apertures, and stomatal movements in response to Cao apparently require Ca2+‐induced Ca2+ release that is likely dependent on Gβγ interaction with PLCs leading to InsP3 production.
Comparison of two ultrasound-guided techniques for greater occipital nerve injections in chronic migraine: a double-blind, randomized, controlled trial
Authors: Flamer David , Alakkad Husni , Soneji Neilesh , Tumber Paul , Peng Philip , Kara Jamal , Hoydonckx Yasmine , Bhatia Anuj 
Published: March 2019

Background and objectives
Two ultrasound (US)-guided techniques for greater occipital nerve (GON) block have been described for the management of headache disorders: a “proximal or central” technique targeting the GON at the level of the second cervical vertebra and a “distal or peripheral” technique targeting the GON at the level of the superior nuchal line. In this multicenter, prospective, randomized control trial, we compared accuracy, effectiveness, and safety of these two techniques in patients with chronic migraines (CMs).

Methods
Forty patients with refractory CMs were randomized to receive either a proximal or distal US-guided GON block with bupivacaine and methylprednisolone acetate. The primary outcome was the difference in Numerical Rating Score (NRS) for headache intensity at 1 month. Secondary outcomes were effectiveness, performance, and safety-related. Effectiveness-related outcomes included NRS for headache intensity, number of headache days per week, patient satisfaction, quality of life, assessment of sleep quality, and sleep interruption. Performance-related outcomes included procedure time, accuracy of block, and patient discomfort. Safety-related outcomes included an assessment for adverse effects.

Results
NRS pain scores were significantly reduced at 24 hours and at 1 week postprocedure in both cohorts and at 1 and 3 months in the proximal group as compared with the baseline. There was no significant difference in NRS pain scores between the two cohorts at any of the follow-up time points. There was a significant reduction in number of headache days per week at 1 month in both groups, and a significant improvement in sleep interruption at 1 week in both groups. There were no significant adverse effects.

Conclusions
This study was designed to compare two different US-guided approaches for blocking the GON. Our results demonstrate that both distal and proximal techniques can provide a short-term improvement in headache intensity, reduction in number of headache days per week, and an improvement in sleep interruption. The proximal GON technique may confer more sustained analgesic benefit compared with the distal approach in patients with CM headaches.

Trial registration number

NCT02031822
.
Autochthonous Angiostrongylus vasorum in Finland
Authors: Tiškina Valentina , Lindqvist Eeva‐Liisa , Blomqvist Anna‐Clara , Orav Merle , Stensvold Christen Rune , Jokelainen Pikka 
Published: March 2019

Angiostrongylus vasorum has spread farther north in Europe. In this study, two autochthonous findings from dogs from Finland are described: in February 2014, the infection was diagnosed in a 10‐month‐old labrador retriever, and in February 2017, in a three‐year‐old French bulldog. These diagnoses were based on direct detection of the larvae from faeces of the dogs. The dogs had no history of travel to or import from abroad; the first lived in Southern Finland and the other in Western Finland, about 150 km apart. The dogs had no clinical signs attributable to angiostrongylosis. An online questionnaire was used to survey the extent to which veterinarians in Finland have self‐reportedly observed canine A vasorum infections. A total of 38 veterinarians authorised to work in Finland answered the questionnaire in December 2017, and 9 (24%) of them reported having seen one or more dogs with A vasorum infection in Finland. The results suggest that at least five individual dogs with A vasorum infection would have been seen in Finland, three of which had an apparently autochthonous infection. While the geographical distribution of A vasorum in Finland remains largely unknown, findings have started to appear from domestic dogs. It remains possible that some veterinarians could have misdiagnosed, for example, Crenosoma vulpis larvae as those of A vasorum, and the findings without confirmation using antigen test could be due to coprophagy and passage of ingested larvae; however, this does not change the main conclusion that can be made: A vasorum is already multifocally present in Finland. Increasing awareness about A vasorum is important in areas where it is emerging and spreading.
Reasoning about Strategic Abilities
Authors: Bulling Nils , Jamroga Wojciech , Popovici Matei 
Published: March 2019

In alternating-time temporal logic ATL*, agents with perfect recall assign choices to sequences of states, i.e., to possible finite histories of the game. However, when a nested strategic modality is interpreted, the new strategy does not take into account the previous sequence of events. It is as if agents collect their observations in the nested game again from scratch, thus, effectively forgetting what they observed before. Intuitively, it does not fit the assumption of agents having perfect recall of the past. In this article, we investigate the alternative semantics for ATL*where the past is not forgotten in nested games. We show that the standard semantics of ATL*coincides with the “truly perfect recall” semantics for agents with perfect information and in case of so-called “objective” abilities under uncertainty. On the other hand, the two semantics differ significantly for the most popular (“subjective”) notion of ability under imperfect information. The same applies to the standard vs. “truly perfect recall” semantics of ATL*with persistent strategies. We compare the relevant variants of ATL*by looking at their expressive power, sets of validities, and tractability of model checking.
O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors
Authors: Efimova Elena V. , Appelbe Oliver K. , Ricco Natalia , Lee Steve S.-Y. , Liu Yue , Wolfgeher Donald J. , Collins Tamica N. , Flor Amy C. , Ramamurthy Aishwarya , Warrington Sara , Bindokas Vytautas P. , Kron Stephen J. 
Published: March 2019

Abstract

The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism in advanced cancer is often ascribed to answering a higher demand for metabolic intermediates required for rapid tumor cell growth. Instead, recent discoveries have pointed to an alternative role for glucose and glutamine metabolites as cofactors for chromatin modifiers and other protein posttranslational modification enzymes in cancer cells. Beyond epigenetic mechanisms regulating gene expression, many chromatin modifiers also modulate DNA repair, raising the question whether cancer metabolic reprogramming may mediate resistance to genotoxic therapy and genomic instability. Our prior work had implicated N-acetyl-glucosamine (GlcNAc) formation by the hexosamine biosynthetic pathway (HBP) and resulting protein O-GlcNAcylation as a common means by which increased glucose and glutamine metabolism can drive double-strand break (DSB) repair and resistance to therapy-induced senescence in cancer cells. We have examined the effects of modulating O-GlcNAcylation on the DNA damage response (DDR) in MCF7 human mammary carcinoma in vitro and in xenograft tumors. Proteomic profiling revealed deregulated DDR pathways in cells with altered O-GlcNAcylation. Promoting protein O-GlcNAc modification by targeting O-GlcNAcase or simply treating animals with GlcNAc protected tumor xenografts against radiation. In turn, suppressing protein O-GlcNAcylation by blocking O-GlcNAc transferase activity led to delayed DSB repair, reduced cell proliferation, and increased cell senescence in vivo. Taken together, these findings confirm critical connections between cancer metabolic reprogramming, DDR, and senescence and provide a rationale to evaluate agents targeting O-GlcNAcylation in patients as a means to restore tumor sensitivity to radiotherapy.

Implications:
The finding that the HBP, via its impact on protein O-GlcNAcylation, is a key determinant of the DDR in cancer provides a mechanistic link between metabolic reprogramming, genomic instability, and therapeutic response and suggests novel therapeutic approaches for tumor radiosensitization.
VICO E ESPINOSA: SOBRE AS VICISSITUDES DAS LÍNGUAS
Authors: Alavina Fran De Oliveira 
Published: March 2019

Não obstante as críticas de Giambattista Vico ao pensamento de Espinosa, é possível estabelecer uma relação de proximidade entre os dois. Se as críticas distanciam, o interesse histórico-filológico aproxima. Com efeito, para o estabelecimento de certa convergência entre os propósitos filosóficos dos dois autores, elencam-se os seguintes pressupostos: i) tanto na Ciência Nova, quanto no Tratado Teológico-Político, a filologia não é apenas conhecimento textual das línguas, porém via de acesso à história de um povo, pois guarda as mutações temporais da vida civil e a memória do mundo de sentido no qual se gesta; ii) a língua não é uma criação do rigor do entendimento, isto é, não é criação dos filósofos, mas da imaginação, portanto do vulgo. Desse modo, toda via de acesso ao conhecimento do passado passa inevitavelmente pela potência da imaginação-fantasia: questão que interpela Espinosa na história dos hebreus e Vico na natureza comum das nações.
Prognostic Implications of Right Ventricular Free Wall Longitudinal Strain in Patients With Significant Functional Tricuspid Regurgitation
Authors: Prihadi Edgard A. , van der Bijl Pieter , Dietz Marlieke , Abou Rachid , Vollema E. Mara , Marsan Nina Ajmone , Delgado Victoria , Bax Jeroen J. 
Published: March 2019

Background
In patients with significant functional tricuspid regurgitation, timely detection of right ventricular (RV) dysfunction with conventional 2-dimensional echocardiography is challenging, whereas speckle-tracking echocardiography RV free wall longitudinal strain has been proposed as better prognosticator. We evaluated the prevalence and prognostic value of impaired RV free wall longitudinal strain in patients with significant functional tricuspid regurgitation, in comparison with tricuspid annular plane systolic excursion (TAPSE) and fractional area change (FAC).

Methods
Eight hundred ninety-six patients (51.3% men, 71 years [62–78 years]) with significant functional tricuspid regurgitation were divided according to the presence of RV dysfunction (defined as TAPSE <17 mm, FAC <35%, and RV free wall longitudinal strain >−23%) and were followed for the occurrence of all-cause mortality.

Results

RV free wall longitudinal strain identified the highest percentage of RV dysfunction (84.9%), in comparison to FAC (48.5%) and TAPSE (71.7%). During a median follow-up of 2.8 years (1.3–5.4 years), 443 (49.4%) patients died. Compared with survivors, nonsurvivors showed worse RV systolic dysfunction (FAC=36.5±12.7% versus 33.9±11.8%,
P
=0.001; TAPSE=15.4±5.0 versus 14.0±4.5 mm,
P
<0.001; RV free wall longitudinal strain=−15.9±7.5% versus −12.9±6.8%,
P
<0.001). Cumulative event-free survival was significantly worse in patients with decreased FAC, decreased TAPSE, and impaired RV free wall longitudinal strain. On multivariate analysis, RV free wall longitudinal strain was independently associated with all-cause mortality and incremental to FAC and TAPSE.

Conclusions
In significant tricuspid regurgitation, impaired RV free wall longitudinal strain identifies higher rates of RV dysfunction and is associated with worse outcome beyond conventional echocardiographic parameters of RV systolic function.
Do-Not-Resuscitate Status and Risk-Standardized Mortality and Readmission Rates Following Acute Myocardial Infarction
Authors: Bruckel Jeffrey , Nallamothu Brahmajee K. , Ling Frederick , Howell Erik H. , Lowenstein Charles J. , Thomas Sabu , Bradley Steven M. , Mehta Anuj , Walkey Allan J. 
Published: March 2019

Background
Important administrative-based measures of hospital quality, including those used by Centers for Medicare and Medicaid Services, may not adequately account for patient illness and social factors that vary between hospitals and can strongly affect outcomes. Do-not-resuscitate (DNR) order on admission (within the first 24 hours) is one such factor that may reflect higher preadmission illness burden as well as patients’ desire for less-intense therapeutic interventions and has been shown to vary widely between hospitals. We sought to evaluate how accounting for early DNR affected hospital quality measures for acute myocardial infarction.

Methods AND RESULTS

We identified all patients admitted with acute myocardial infarction using the California State Inpatient Database, which captures early DNR use within 24 hours of admission. We generated hospital risk-standardized mortality and readmissions using random-effects logistic regression, before and after including early DNR status, to examine changes in overall model fit and hospital outlier designations. We included 109 521 patients from 289 hospitals and found that 8.5% (9356) patients had early DNR. Early DNR use varied widely, with median (interquartile range) hospital rates of 7.9% (4.1%–14.0%). Including early DNR in models used to assess hospital quality resulted in improvement in the mortality model (C statistics from 0.754 [0.748–0.759] to 0.784 [0.779–0.789]) but not the readmissions model. Of the hospitals designated high outliers for mortality and readmissions by the Centers for Medicare/Medicaid Services model, and therefore destined for a financial penalty, 6/25 (24%) were reclassified as nonoutliers for mortality and 2/14 (14.3%) for readmissions after including DNR status. Agreement in outlier status between the models before and after inclusion of early DNR status was moderate for mortality (κ, 0.603 [0.482–0.724];
P
<0.001) and high for readmissions (κ, 0.888 [0.800–0.977];
P
<0.001).

Conclusions
Including early DNR status in risk-adjustment models significantly improved model fit and resulted in substantial reclassification of hospital performance rankings for mortality and moderate reclassification for readmissions. DNR status at hospital admission should be considered when reporting risk-standardized hospital mortality.