bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taq1A polymorphism and medication effects on inhibitory action control in Parkinson disease
Authors: McDonell Katherine E. , van Wouwe Nelleke C. , Harrison Madaline B. , Wylie Scott A. , Claassen Daniel O. 
Published: June 2018

AbstractBackgroundDopamine therapy in Parkinson disease (PD) can have differential effects on inhibitory action control, or the ability to inhibit reflexive or impulsive actions. Dopamine agonist (DAAg) medications, which preferentially target D2 and D3 receptors, can either improve or worsen control of impulsive actions in patients with PD. We have reported that the direction of this effect depends on baseline levels of performance on inhibitory control tasks. This observation suggests that there may exist certain biologic determinants that contribute to these patient‐specific differences. We hypothesized that one important factor might be functional polymorphisms in D2‐like receptor genes.AimThe goal of this study was to determine whether the direction of DAAg effects on inhibitory control depends on functional polymorphisms in the DRD2 and DRD3 genes.MethodsTwenty‐eight patients with PD were genotyped for known functional polymorphisms in DRD2 (rs6277 and rs1800497) and DRD3 (rs6280) receptors. These patients then completed the Simon conflict task both on and off DAAg therapy in a counterbalanced manner.ResultsWe found that patients with the rs1800497 Taq1A (A1) polymorphism (A1/A1 or A1/A2: 11 subjects) showed improved proficiency to suppress impulsive actions when on DAAg; conversely, patients with the A2/A2 allele (14 patients) became less proficient at suppressing incorrect response information on DAAg therapy (Group × Medication, F(1, 23) = 5.65, p < 0.05). Polymorphisms in rs6277 and rs6280 were not associated with a differential medication response.ConclusionThese results suggest that certain DRD polymorphisms may determine the direction of DAAg effects on critical cognitive control processes impaired in PD. Our findings have implications for understanding pharmacogenomics interactions on a larger scale and the role these may play in the wide variability of treatment effects seen in the PD population.
A prognostic model, including the EBV status of tumor cells, for primary gastric diffuse large B‐cell lymphoma in the rituximab era
Authors: Ishikawa Eri , Tanaka Tsutomu , Shimada Kazuyuki , Kohno Kei , Satou Akira , Eladl Ahmed E. , Sakakibara Ayako , Furukawa Kazuhiro , Funasaka Kohei , Miyahara Ryoji , Nakamura Masanao , Goto Hidemi , Nakamura Shigeo , Kato Seiichi , Hirooka Yoshiki 
Published: June 2018

AbstractEBV‐positive diffuse large B‐cell lymphoma (DLBCL), not otherwise specified (NOS), often affects the gastrointestinal tract. However, the prognostic significance of EBV associated with primary gastric DLBCL (gDLBCL) has not been established. This retrospective study included 240 patients with primary gDLBCL, diagnosed between 1995 and 2015. Tumor specimens were analyzed with EBER in situ hybridization. In 25 (10%) cases, tumor cells harbored EBV. The EBV+ group more frequently exhibited programmed death‐ligand 1 (PD‐L1) expression in microenvironment immune cells, but not tumor cells, compared to the EBV− group (86% vs 43%, P = .006). Among 156 patients that received rituximab‐containing chemotherapy, the EBV+ group had a significantly worse overall survival (OS) than the EBV− group (P = .0029). Multivariate analyses identified 3 independent adverse prognostic factors of OS: multiple gastric lesions (P = .002), EBER positivity (P = .003), and B symptoms (P = .018). These factors were combined to develop a gDLBCL prognostic (gDLP) model that significantly stratified the patients into 3 distinct risk groups (Scores: good = 0, intermediate = 1, and poor = 2/3, P < .0001) with 5‐year OS rates of 100%, 81%, and 39%, respectively. Patients with EBV+ gDLBCL commonly exhibited microenvironmental PD‐L1 expression and showed a significantly worse prognosis than subjects with EBV− gDLBCL. Our gDLP model, which included EBV+ tumor cells, provided good predictions of clinical outcome and may be useful for selecting patients in trials in the immune‐oncology era.
Targeted photodynamic therapy of cancer using a novel gallium (III) tris (ethoxycarbonyl) corrole conjugated‐mAb directed against cancer/testis antigens 83
Authors: Ye Ziyu , Liang Yanfang , Ma Yan , Lin Bihua , Cao Longbin , Wang Bin , Zhang Zhao , Yu Haibo , Li Jixia , Huang Mingyuan , Zhou Keyuan , Zhang Qunzhou , Liu Xinguang , Zeng Jincheng 
Published: June 2018

AbstractPhotodynamic therapy (PDT) is a noninvasive, highly selective approach to the treatment of tumors. However, its therapeutic effect is limited by long‐lasting skin phototoxicity. Therefore, to compromise this shortcoming, it is preferable to deliver photosensitizers selectively to tumor cells with the aid of antibodies specific against tumor‐associated antigens. Cancer/testis antigens 83 (CT83), also called KK‐LC‐1 or CXorf61, recognized by cytotoxic T lymphocytes (CTL), has become a promising target for immunotherapy. Herein, we developed and characterized a novel mouse CT83 mAb 7G4 with a high affinity with Gallium (III) 5, 10, 15‐tris (ethoxycarbonyl) corrole (1‐Ga), a new and promising photosensitizer in PDT. The enzyme‐linked immunosorbent assay (ELISA), flow cytometry and cytotoxicity activity assays revealed that 7G4‐1‐Ga was able to recognize human CT83 with high specificity. Furthermore, 7G4‐1‐Ga showed greater cytotoxicity to CT83‐expressing human cancer cells in vitro than 1‐Ga. These results suggest that the antibody‐conjugated photosensitizer between anti‐CT83 mAb and 1‐Ga may have a good application in PDT, where the destruction of CT83‐expressing tumor is required.
Challenges and prospects of competency‐based education: The case of adama science and technology university alumni students and hawas TVET college, adama, ethiopia
Authors: Likisa Kumsa Donis 
Published: June 2018

BackgroundTechnical and Vocational Education and Training (TVET) is one of the salient priority areas in Ethiopian education system. TVET was designed to redress the challenges of poverty, unemployment, low technological development, and low productivity of the economy (MoE, ). The TVET along with competency‐based education (CBE) was introduced in Ethiopia in 2004 in response to the skill needs of the labor market (MoE, 2006).AimsThe primary aim of this study was to examine whether the TVET curricula clearly aligned with occupational standards to ensure graduates’ employability. It was also to examine whether the curriculum is adequate to ensure entry‐level competence.MethodsThe main sources of information were three experts from center of competency, 64 teachers and 210 selected alumni students of Adama Science and Technology University. Questionnaire was used to gather information from the research participants. In the analysis of data, descriptive statistics such as frequency, percentages and mean scores were employed.ResultsFrom the analysis of data, it was found that CBE is not clearly aligned with occupational standards. Also, teachers, Center of Competency (CoC) experts, and alumni students’ awareness of the nature, focus, assessment, and curriculum development of CBE was found to be inadequate.ConclusionThis study showed the need to align CBE with occupational standards to ensure entry‐level competence. There is also a need to create awareness about the nature, focus, assessment and curriculum development of CBE among curriculum designers/teachers.
Cyclic thrombocytopenia with statistically significant neutrophil oscillations
Authors: Langlois Gabriel P. , Arnold Donald M. , Potts Jayson , Leber Brian , Dale David C. , Mackey Michael C. 
Published: June 2018

Key Clinical MessageCyclic thrombocytopenia is often misdiagnosed as immune thrombocytopenia due to similar clinical features, a fact of significance because cyclic thrombocytopenia generally responds poorly to treatments used successfully in immune thrombocytopenia. A precise diagnosis must establish the statistical significance of periodicity of the platelet counts using statistical methods (eg, Lomb‐Scargle periodogram).
Acupuncture point injection markedly improved sensory symptoms and motor signs in 2 patients with restless legs syndrome
Authors: Fukutome Takero 
Published: June 2018

Key Clinical MessageThe acuinjections at acupuncture points (GB41, BL60, ST36, and SP6) provide immediate relief of sensory symptoms and motor signs of restless legs symptom (RLS). An acuinjection can be promising and safe alternative treatment for pharmacotherapy in patients of RLS.
Formation and Extractive Desulfurization Mechanisms of Aromatic Acid Based Deep Eutectic Solvents: An Experimental and Theoretical Study
Authors: Zhao Xiuxiu , Zhu Guoqiang , Jiao Lingying , Yu Fengli , Xie Congxia 
Published: June 2018

AbstractThe formation and extractive desulfurization (EDS) mechanisms of aromatic acid based deep eutectic solvents (DESs) were studied experimentally and through quantum chemistry calculations. Hydrogen bonding and van der Waals forces were investigated as the driving forces for the formation of aromatic acid based DESs by means of 1H NMR and FTIR spectroscopy, and DFT calculations. The driving forces of EDS were also studied. The results showed that van der Waals forces and other weak interactions were the main diving forces for EDS, and the structures of the aromatic acid based DESs did not change after EDS. The interaction energy between the aromatic acid based DESs and thiophene (TH), benzothiophene (BT), and dibenzothiophene (DBT) were calculated by DFT to understand the EDS order: TH<BT<DBT. Moreover, the optimal EDS conditions were studied. The amount of BT (500 ppm) was reduced to below 10 ppm under the optimal conditions of using triethylamine/o‐hydroxybenzoic acid ([TEA]/[OHBA]). The desulfurization efficiency of [TEA]/[OHBA] was stable after ten cycles, and the mechanical loss of [TEA]/[OHBA] could be ignored.
Selective Synthesis of a Series of Isostructural MIICuI Heterobimetallic Complexes Spontaneously Assembled by an Unsymmetrical Naphthyridine‐Based Ligand
Authors: Nicolay Amélie , Tilley T. Don 
Published: June 2018

AbstractMetal–metal cooperation is integral to the function of many enzymes and materials, and model complexes hold enormous potential for providing insights into the capabilities of analogous multimetallic cores. However, the selective synthesis of heterobimetallic complexes still presents a significant challenge, especially for systems that hold the metals in close proximity and feature open or reactive coordination sites for both metals. To address this issue, a rigid, naphthyridine‐based dinucleating ligand featuring distinct binding environments was synthesized. This ligand enables the selective synthesis of a series of MIICuI bimetallic complexes (M=Mn, Fe, Co, Ni, Cu, Zn), in which each metal center exclusively occupies its preferred binding pocket, from simple chloride salts. The precision of this selectivity is evident from cyclic voltammetry, ESI‐MS and anomalous X‐ray diffraction measurements.
Synergy of Axial and Point Chirality to Construct Helical N‐Heterotriangulene‐Based Supramolecular Polymers
Authors: Dorca Yeray , Valera Jorge S. , Cerdá Jesús , Aragó Juan , Gómez Rafael , Ortí Enrique , Sánchez Luis 
Published: June 2018

AbstractWe report on the cooperative supramolecular polymerization of a series of N‐heterotriangulenes that aggregate into helical columnar stacks by the operation of H‐bonding interactions between the peripheral amide groups and π‐stacking of the central aromatic moieties. The helical outcome of the highly stable supramolecular polymers stems from the joint effect of the point chirality dictated by the stereogenic centers at the side chains that, in turn, conditions the molecular atropisomerism generated by the restricted rotation of the peripheral benzamide moieties affording a propeller‐like geometry. To the best of our knowledge, this is the first example in which two different elements of asymmetry act together to bias the helicity of chiral supramolecular polymers.
Differentially localized survivin and STAT3 as markers of gastric cancer progression: Association with Helicobacter pylori
Authors: Pandey Arvind , Tripathi Satyendra Chandra , Shukla Shirish , Mahata Sutapa , Vishnoi Kanchan , Misra Sri Prakash , Misra Vatsala , Mitra Sankar , Dwivedi Manisha , Bharti Alok C. 
Published: June 2018

AbstractBackgroundLocalization and differential expression of STAT3 and survivin in cancer cells are often related to distinct cellular functions. The involvement of survivin and STAT3 in gastric cancer has been reported in separate studies but without clear understanding of their kinetics in cancer progression.MethodsWe examined intracellular distribution of STAT3 and survivin in gastric adenocarcinoma and compared it with normal and precancer tissues using immunoblotting and immunohistochemistry.ResultsAnalysis of a total of 156 gastric samples comprising 61 histologically normal, 30 precancerous tissues (comprising intestinal metaplasia and dysplasia), and 65 adenocarcinomas, collected as endoscopic biopsies from treatment naïve study participants, revealed a significant (P < .001) increase in overall protein levels. Survivin expression was detectable in both cytoplasmic (90.8%) and nuclear (87.7%) compartments in gastric adenocarcinomas lesions. Precancerous dysplastic gastric lesions exhibited a moderate survivin expression (56.7%) localized in cytoplasmic compartment. Similarly, STAT3 and pSTAT3 expression was detected at high level in gastric cancer lesions. The levels of compartmentalized expression of survivin and STAT3/pSTAT3 correlated in precancerous and adenocarcinoma lesions. Although overexpression of these proteins was found associated with the tobacco use and alcohol consumption, their expression invariably and strongly correlated with concurrent Helicobacter pylori infection. Receiver operating characteristic analysis of nuclear survivin, STAT3, and pSTAT3 in different study groups showed acceptable positive and negative predictive values with area under the curve above 0.8 (P < .001).ConclusionOverall, our results suggest that overall increase in survivin and STAT3 and their subcellular localization are key determinants of gastric cancer progression, which can be collectively used as potential disease biomarkers and therapeutic targets for gastric cancer.
Photoluminescent Carbon Dots: A Mixture of Heterogeneous Fractions
Authors: Zhou Yiqun , Liyanage Piumi Y. , Geleroff Daniel L. , Peng Zhili , Mintz Keenan J. , Hettiarachchi Sajini D. , Pandey Raja R. , Chusuei Charles C. , Blackwelder Patricia L. , Leblanc Roger M. 
Published: June 2018

AbstractPhotoluminescent carbon dots (CDs) fractions have been isolated from a gel‐like material (GM), which was synthesized using a convenient one‐step solvothermal route. In terms of purification, size exclusion chromatography (SEC) and dialysis were compared with acetone wash, which revealed the advantage of acetone wash. The pre‐purified GM with acetone wash (A‐GM) was further isolated by the reversed‐phase preparative thin layer chromatography (TLC) with acetonitrile−water mixture (7 : 3; va/vw) as the developing solvent. As a result, there were four photoluminescent bands on the TLC plate, which indicated the presence of four photoluminescent fractions. Detailed characterization measurements such as UV/Vis absorption, fluorescence emission, attenuated total reflection Fourier‐transform infrared spectroscopy, X‐ray photoelectron spectroscopy, zeta potential, dynamic light scattering, atomic force microscopy, and TEM measurements were performed on all fractions to analyze their heterogeneous optical, structural, electrical, and morphological properties. Considering the comprehensive analysis, all isolated fractions were CDs. In addition, excitation wavelength‐independent CDs were obtained with a mean size of 2.5 nm and high quantum yield (55 %). Furthermore, the study demonstrates that the excitation wavelength‐dependent photoluminescence of GM could result from the mixture of different surface states of each CD fraction rather than multiple surface states of uniform CDs nanoparticles.
Assessing Elementary Teachers' Content Knowledge for Teaching Science for theETS® Educator Series: Pilot Results
Authors: Mikeska Jamie N. , Kurzum Christopher , Steinberg Jonathan H. , Xu Jun 
Published: June 2018

AbstractThe purpose of this report is to examine the performance of assessment items designed to measure elementary teachers' content knowledge for teaching (CKT) science as part of theETS® Educator Series. The Elementary Education: CKT Science assessment is 1 component of licensure examination through thePRAXIS® assessments. The Elementary Education: CKT Science assessment is designed to determine whether kindergarten through 6th‐grade elementary teacher candidates have the essential content knowledge needed for teaching elementary science as new teachers at the entry level. This report provides information about the development of the Elementary Education: CKT Science framework and the associated assessment items. The main part of the report focuses on the evidence gathered when piloting 104 CKT science assessment items with 417 preservice and novice elementary teachers. This evidence included the following: (a) how these new CKT science assessment items function, including their item difficulties and discrimination, and reliabilities of the pilot forms and of the classification of examinees; (b) how teachers perceive the importance and relevance of these new assessment items; (c) how teachers' performances on these items relate to their background characteristics and professional and academic preparation; and (d) how teachers' performances on the CKT science items compare to their performances on an assessment designed to measure only their science subject matter knowledge.
Hybrid methods for shotcrete and segmental linings tunnel shells – Combining displacement and rotation measurements with computational multiscale mechanics
Authors: Pichler Bernhard , Hellmich Christian 
Published: June 2018

AbstractThis contribution highlights recent developments in the analysis and monitoring of tunnel linings based on so‐called hybrid methods. In this context, the word ”hybrid“ refers to a suitable combination of measurement data from geotechnical monitoring, with advanced simulation tools of engineering mechanics. The first part of this contribution refers to the New Austrian Tunneling Method (NATM), where monitoring during construction includes daily measurements of the 3D displacement vectors of ”measurement points“ installed in ”measurement cross‐sections“. Shell theory‐informed spatial and temporal interpolation of the displacements between the aforementioned ”grid points“, allows for reconstructing the evolution of the displacement and strain fields throughout the tunnel shell. Feeding these fields into realistic thermo‐chemo‐mechanical, potentially multiscale, models for the chemically hardening and creeping shotcrete, allows for the determination of the lining stresses over time. The latter give access to corresponding safety indicators or utilization degrees considering the evolving strength of shotcrete; and they also allow for quantifying the traction forces acting from the rock mass, on the exterior boundary of the tunnel lining. The second part of this contribution refers to the first steps towards the hybrid analysis of segmental lining, as installed in mechanized tunnelling. Relative rotation angles, as measured, in the course of a full‐scale test, in the joints between adjacent segments of a segmental ring, are prescribed on a structural mechanics model based on analytical solutions from circular arch theory.
Detection of voids in the annular gap using ground penetrating radar and determination of the in‐situ deformation properties of pea gravel
Authors: Henzinger Michael R. , Willmes Michael , Lagger Manuel , Kathage Andreas F. , Moritz Bernd A. , Schubert Wulf 
Published: June 2018

AbstractWhen using shield machines, the excavation support is established using prefabricated concrete segments. The structurally required cavity between the built ring and the rock mass is usually filled with pea gravel in hard rock conditions. The backfilled material ensures the necessary bedding and evenly distributes the rock loads. To evaluate the in‐situ deformation behaviour of pea gravel, a testing device was developed that measures the reaction of the backfill under load increase and load decrease on the basis of the static load plate test. The test is carried out via the opening for pea gravel injection. The results have shown that the elasticity of pea gravel is predominantly influenced by the load level and the type of loading.Subsequently, the detectability of possible voids in the annular gap was evaluated by means of ground penetration radar. For this purpose, the feasibility of the measurements was confirmed by a numerical study. Furthermore, the boundary conditions and the propagation behaviour of the electromagnetic waves could be demonstrated. With calibration measurements, the electromagnetic properties of all components involved in the system segmental lining and annular gap were determined. An extensive series of analogue model tests confirmed the detectability of the transitions from dry, wet and water‐saturated pea gravel to water‐ and air‐filled voids. In the final series of experiments, the transition between pea gravel and hollow space in the annular gap was successfully detected at on‐site installed lining segments.
Many Roads to Another World
Authors: Deitelhoff Nicole , Daphi Priska , Anderl Felix 
Published: June 2018

Abstract“Another World is Possible”: under this motto, a transnational movement is opposing neoliberal globalisation. While activists share an image of neoliberal globalisation as being unfair and destructive, the forms their protest takes are as varied as their short‐term and long‐term goals. A comparative perspective reveals how the repertoire of social movements forms and reforms.