bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time indocyanine green angiography with the SPY fluorescence imaging platform decreases benign ureteroenteric strictures in urinary diversions performed during radical cystectomy
Authors: Shen Jim K. , Jamnagerwalla Juzar , Yuh Bertram E. , Bassett Mitchell R. , Chenam Avinash , Warner Jonathan N. , Zhumkhawala Ali , Yamzon Jonathan L. , Whelan Christopher , Ruel Nora H. , Lau Clayton S. , Chan Kevin G. 
Published: April 2019

Background: Ischemia is thought to contribute to benign ureteroenteric stricture (UES) after radical cystectomy with urinary diversion (RCUD). Our institution adopted the use of ureteral perfusion assessment during all RCUDs using real-time indocyanine green angiography using the SPY fluorescence imaging platform (Stryker Corp., Kalamazoo, MI, USA). This guides the location of ureteral transection prior to ureteroenteric anastomosis. We sought to compare UES rates before and after adoption of SPY. Methods: A retrospective chart review was undertaken for the first 47 consecutive cases of RCUD using SPY as well as the previous 47 consecutive cases, which were performed without SPY. Fisher’s exact and Wilcoxon rank-sum tests were used to compare benign UES rates and the length of ureter excised during anastomosis. A p < 0.05 indicated statistical significance. Results: Median follow up was 12.0 months for SPY cases and 24.3 months for non-SPY cases. The UES rate for SPY RCUDs was 0% (0/93 ureters) compared with 7.5% (7/93 ureters) for non-SPY RCUDs ( p = 0.01). Amongst SPY RCUDs, 86 ureters had no hydronephrosis and 7 had mild hydronephrosis with reflux on loopogram. A total of 34.4% of ureters (32/93) had poor distal perfusion, requiring a more proximal anastomosis. The median length excised for ureters with poor distal perfusion was 3.8 cm, compared with 2.2 cm for ureters with good distal perfusion ( p < 0.0001). No complications attributable to the use of SPY were noted. Conclusion: Use of SPY to assess ureteral perfusion was associated with a decrease in the UES rate after RCUD. A total of 34.4% of ureters demonstrated poor distal perfusion, requiring a significantly more proximal ureteroenteric anastomosis.
Increasing stone complexity does not affect fluoroscopy time in percutaneous nephrolithotomy
Authors: Vollstedt Annah , Ingimarsson Johann , Dagrosa Lawrence , Pais Vernon 
Published: April 2019

Background: The aim of this work was to assess whether stone complexity with the Guy’s stone score (GSS) is associated with increased intraoperative fluoroscopy time. Methods: We retrospectively reviewed records of 261 consecutive patients undergoing percutaneous nephrolithotomy between 2007 and 2015. Of these, 203 had both preoperative computed tomography for accurate staging and full intraoperative fluoroscopy and radiation dosimetry data were available. Stone complexity was assessed using GSS. A correlation between fluoroscopy time (FT) and GSS was assessed in a univariate and multivariate fashion, including parameters such as age, sex, body mass index (BMI), and number of accesses. Results: The overall mean FT was 3.69 min [standard deviation (SD) 2.77]. The overall mean Guy’s score was 2.5 (SD 1). There was a statistically significant correlation between operative time and FT ( r = 0.34, p < 0.0001). There was a trend towards increasing operative time with increasing GSS ( r = 0.12, p = 0.08), but there was no statistically significant correlation. There was no correlation between FT and GSS ( r = 0.04, p = 0.55). On multivariable regression, accounting for sex, BMI, age, and singular versus multiple accesses, there was no significant correlation between stone complexity and FT ( p = 0.893). Conclusions: In the setting of conscious efforts to reduce intraoperative radiation exposure, increasing stone complexity, as classified by GSS, did not correlate with FT on univariate or multivariate analysis. Thus, treatment of more complex stones may be undertaken without concern that there is an inevitable need for significantly increased fluoroscopy exposure to the patient or operating room staff.
Conditioning Brain Responses to Improve Quadriceps Function in an Individual With Anterior Cruciate Ligament Reconstruction
Authors: Krishnan Chandramouli , Washabaugh Edward P. , Dutt-Mazumder Aviroop , Brown Scott R. , Wojtys Edward M. , Palmieri-Smith Riann M. 
Published: April 2019

Background: Persistent quadriceps weakness and activation failure are common in individuals with anterior cruciate ligament (ACL) reconstruction. A growing body of evidence indicates that this chronic quadriceps dysfunction could be partly mediated due to reduced corticospinal excitability. However, current rehabilitation approaches do not directly target corticospinal deficits, which may be critical for restoring optimal clinical outcomes after the surgery. This case study tested the feasibility of operant conditioning of torque responses evoked by transcranial magnetic stimulation (TMS) to improve quadriceps function after ACL reconstruction. Hypothesis: Operant conditioning of motor evoked torque responses would improve quadriceps strength, voluntary activation, and corticospinal excitability. Study Design: Case study and research report. Level of Evidence: Level 5. Methods: A 24-year-old male with an ACL reconstruction (6 months postsurgery) trained for 20 sessions (2-3 times per week for 8 weeks) to increase his TMS-induced motor evoked torque response (MEP torque) of the quadriceps muscles using operant conditioning principles. Knee extensor strength, voluntary quadriceps muscle activation, and quadriceps corticospinal excitability were evaluated at 3 time points: preintervention (pre), 4 weeks (mid), and immediately after the intervention (post). Results: The participant was able to successfully condition (ie, increase) the quadriceps MEP torque after 1 training session, and the conditioned MEP torque gradually increased over the course of 20 training sessions to reach about 500% of the initial value at the end of training. The participant’s control MEP torque values and corticospinal excitability, which were measured outside of the conditioning paradigm, also increased with training. These changes were paralleled by improvements in knee extensor strength and voluntary quadriceps muscle activation. Conclusion: This study shows that operant conditioning of MEP torque is a feasible approach to improving quadriceps corticospinal excitability and quadriceps function after ACL reconstruction and encourages further testing in a larger cohort of ACL-reconstructed individuals. Clinical Relevance: Operant conditioning may serve as a potential therapeutic adjuvant for ACL rehabilitation.
The Expressions of Dickkopf-Related Protein 1 and Frizzled-Related Protein Are Negatively Correlated to Local Inflammation and Osteoarthritis Severity
Authors: Huang Xiaobin , Zhong Leilei , van Helvoort Eefje , Lafeber Floris , Mastbergen Simon , Hendriks Jan , Post Janine N. , Karperien Marcel 
Published: April 2019

Objective To investigate the presence of WNT antagonists Dickkopf-related protein 1 (DKK1), Frizzled-related protein (FRZB) and BMP antagonist Gremlin 1 (GREM1) in synovial fluid (SF) and serum, respectively, from end-stage knee osteoarthritis (OA) patients, and correlate their expression with other markers of OA. Design In a cross-sectional study, SF and serum were collected from OA patients ( n = 132). The concentrations of DKK1, FRZB and GREM1 in SF and serum were determined using immunoassays. Correlation measurements were performed between groups and previously assessed disease markers, such as synovium nitric oxide (NO), inerleukin-1β (IL1β), tumor necrosis factor–α (TNFα), and prostaglandin E2 (PGE2). Results The OA patients with the celecoxib treatment till surgery have higher median SF FRZB values compared with the control (no treatment); the celecoxib 3-days before surgery stopped treatment group has higher median serum FRZB values than the control and the naproxen treatment group. The combinational analysis of SF DKK1 and SF FRZB negatively correlated with macroscopic cartilage scores and histological synovium scores in OA patients. The expression of DKK1 and FRZB in SF showed the same expression trend as their expression in serum. Furthermore, the SF concentration of DKK1 was positively correlated with FRZB in both SF and serum. In contrast, it was negatively correlated with synovium NO and IL1β. SF FRZB was negatively correlated with synovium NO, IL1β, cartilage PGE2, and age. Conclusions Our findings suggest DKK1 and FRZB were negatively correlated with OA severity and multiple pro-inflammatory cytokines. Our data indicate that DKK1 and FRZB can be joint disease–specific biomarkers.
Use of mobile applications in the management of overweight and obesity in primary and secondary care
Authors: Alnuaimi Asmaa , Rawaf Salman , Hassounah Sondus , Chehab Mohamad 
Published: April 2019

Summary Mobile technology has emerged as a potentially useful application in the process of facilitating weight loss management. While several empirical studies have demonstrated the positive effects of mobile-based interventions, the extent of such effectiveness is still a topic of debate. Thus, the current systematic review involved searching electronic databases for studies on the use of mobile app-based interventions in the management of overweight and obesity among adults over 18 years of age in a primary and secondary care setting. The results of the review revealed that mobile apps are effective tools for weight loss management and sustaining such loss when compared to standard interventions. However, further research is needed to consider the sustained benefits and the applicability of mobile app-based interventions for large-scale population coverage.
Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence
Authors: Sinha Saloni , Dwivedi Tirath Raj , Yengkhom Roja , Bheemsetty Venkata Anudeep , Abe Takaya , Kiyonari Hiroshi , VijayRaghavan K. , Inamdar Maneesha S. 
Published: April 2019

Abstract
Inactivation of the tumor suppressor p53 is essential for unrestrained growth of cancers. However, only 11% of hematological malignancies have mutant p53. Mechanisms that cause wild-type p53 dysfunction and promote leukemia are inadequately deciphered. The stem cell protein Asrij/OCIAD1 is misexpressed in several human hematological malignancies and implicated in the p53 pathway and DNA damage response. However, Asrij function in vertebrate hematopoiesis remains unknown. We generated the first asrij null (knockout [KO]) mice and show that they are viable and fertile with no gross abnormalities. However, by 6 months, they exhibit increased peripheral blood cell counts, splenomegaly, and an expansion of bone marrow hematopoietic stem cells (HSCs) with higher myeloid output. HSCs lacking Asrij are less quiescent and more proliferative with higher repopulation potential as observed from serial transplantation studies. However, stressing KO mice with sublethal γ irradiation or multiple injections of 5-fluorouracil results in reduced survival and rapid depletion of hematopoietic stem/progenitor cells (HSPCs) by driving them into proliferative exhaustion. Molecular and biochemical analyses revealed increased polyubiquitinated protein levels, Akt/STAT5 activation and COP9 signalosome subunit 5 (CSN5)-mediated p53 ubiquitination, and degradation in KO HSPCs. Further, we show that Asrij sequesters CSN5 via its conserved OCIA domain, thereby preventing p53 degradation. In agreement, Nutlin-3 treatment of KO mice restored p53 levels and reduced high HSPC frequencies. Thus, we provide a new mouse model resembling myeloproliferative disease and identify a posttranslational regulator of wild-type p53 essential for maintaining HSC quiescence that could be a potential target for pharmacological intervention.
Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial
Authors: Forlenza Orestes V. , Radanovic Márcia , Talib Leda L. , Gattaz Wagner F. 
Published: April 2019

BackgroundExperimental studies indicate that lithium may facilitate neurotrophic/protective responses in the brain. Epidemiological and imaging studies in bipolar disorder, in addition to a few trials in Alzheimer's disease support the clinical translation of these findings. Nonetheless, there is limited controlled data about potential use of lithium to treat or prevent dementia.AimsTo determine the benefits of lithium treatment in patients with amnestic mild cognitive impairment (MCI), a clinical condition associated with high risk for Alzheimer's disease.MethodA total of 61 community-dwelling, physically healthy, older adults with MCI were randomised to receive lithium or placebo (1:1) for 2 years (double-blind phase), and followed-up for an additional 24 months (single-blinded phase) (trial registration at clinicaltrials.gov: NCT01055392). Lithium carbonate was prescribed to yield subtherapeutic concentrations (0.25–0.5 mEq/L). Primary outcome variables were the cognitive (Alzheimer's Disease Assessment Scale – cognitive subscale) and functional (Clinical Dementia Rating – Sum of Boxes) parameters obtained at baseline and after 12 and 24 months. Secondary outcomes were neuropsychological test scores; cerebrospinal fluid (CSF) concentrations of Alzheimer's disease-related biomarkers determined at 0, 12 and 36 months; conversion rate from MCI to dementia (0–48 months).ResultsParticipants in the placebo group displayed cognitive and functional decline, whereas lithium-treated patients remained stable over 2 years. Lithium treatment was associated with better performance on memory and attention tests after 24 months, and with a significant increase in CSF amyloid-beta peptide (Aβ1−42) after 36 months.ConclusionsLong-term lithium attenuates cognitive and functional decline in amnestic MCI, and modifies Alzheimer's disease-related CSF biomarkers. The present data reinforces the disease-modifying properties of lithium in the MCI–Alzheimer's disease continuum.Declaration of interestNone.
Trends in Step-determined Physical Activity among Japanese Adults from 1995 to 2016
Authors: TAKAMIYA TOMOKO , INOUE SHIGERU 
Published: April 2019

ABSTRACT

Purpose
We tried to clarify the trends in step-determined physical activity (PA) among Japanese adults from 1995 to 2016.

Methods
Raw data from the National Health and Nutrition Surveys Japan (NHNS-J) performed between 1995 and 2016 were used, in compliance with the Statistics Act of Japan. NHNS-J was conducted annually by the Japanese government (the Ministry of Health, Labour, and Welfare) using a representative Japanese sample, with the same sampling method every year except in 2012 and 2016. A 1-d pedometer survey was conducted each year as a part of the NHNS-J, on a weekday in November specified by each individual. Because of the difference in age distribution of the samples, age-adjusted mean steps per day were calculated from 1995 to 2016 by sex. The time trends of step-determined PA levels among Japanese adults were described and examined using Joinpoint regression.

Results
The highest age-adjusted mean number of steps for men was 8235 steps per day in 2000, whereas it was 7667 steps per day in 2015. The highest age-adjusted mean numbers of steps for women were 7474 steps per day in 1998 and 6691 steps per day in 2015. The age-adjusted step-determined PA trend showed significantly decreasing trend from 1997 to 2008 in men (annual percentage change, −0.74; P < 0.001) and from 1998 to 2008 (annual percentage change, −1.30; P < 0.001) in women, by Joinpoint regression.

Conclusion
The age-adjusted step-determined PA among Japanese adults between 1995 and 2016 decreased from around 1997 to 1998 until around 2008, but since then, the decreasing trend became unclear both in men and in women. Continuous monitoring of PA trends is essential to assess the effectiveness of policies.
Match Play–induced Changes in Landing Biomechanics with Special Focus on Fatigability
Authors: SMEETS ANNEMIE , VANRENTERGHEM JOS , STAES FILIP , VERSCHUEREN SABINE 
Published: April 2019

ABSTRACT

Introduction
Growing evidence exists that match-related fatigue induces biomechanical alterations that might increase lower extremity injury risk. Fatigue studies often use match simulation protocols that expose all subjects to a standardized demand (e.g., a fixed distance/time). In those studies, the induced level of fatigue depends then on subjects’ fatigability. If between-subject variability in fatigability is high, this might confound overall fatigue effects. Therefore, the first aim was to investigate whether a fatigue protocol with fixed demand causes alterations in landing patterns. Second, we assessed the relationship between fatigability and landing patterns as we hypothesized that athletes with high fatigability would show movement patterns that involve greater injury risk.

Methods
Eighteen athletes performed three different unilateral landing tasks before and after a match simulation protocol while muscle activation (vastus medialis, vastus lateralis, hamstrings medialis, hamstrings lateralis, gastrocnemius medialis, gastrocnemius lateralis, and gluteus medius) and landing kinematics and kinetics of the hip, knee, and ankle joint were recorded. Furthermore, RPE was administered to measure fatigability. ANOVA analyses were conducted to investigate fatigue effects on landing patterns. Correlation analyses assessed the relationship between fatigability (postfatigue RPE) and landing patterns.

Results
The ANOVA analyses did not show any overall postfatigue alterations in landing patterns. However, correlation analyses showed an association between fatigability and landing patterns. Athletes who had higher RPE scores showed smaller postfatigue knee flexion angles and smaller pre- and postfatigue knee abduction angles across different landing tasks.

Conclusion
The fixed demand protocol did not cause overall alterations in landing patterns. When fatigability was taken into account, high fatigability was related with less optimal landing patterns.
Enfances à l’école
Authors: Giraud Frédérique 
Published: April 2019

L’enjeu de ce dossier est de rappeler, contre la tentation « naturalisante » du monde social, que la définition scolaire de l’enfance, comme un âge des apprentissages, n’est ni naturelle, ni unanimement partagée par les acteurs en charge de son instruction. Les professionnels de l’éducation des enfants ne partageant ni la même définition de ce que sont des enfants ou des élèves, ni les mêmes représentations de ce qu’ils devraient être capables de faire ou d’apprendre, mettent en œuvre des pratiques hétérogènes. C’est pourquoi le mot enfances est proposé au pluriel : il s’agit bien de poser comme hypothèse de travail indépassable que « l’enfance n’est qu’un mot », à l’instar de Bourdieu qui démontrait que l’on ne pouvait parler de la jeunesse au singulier (1980). Le sociologue rappelle en effet que l’on ne peut raisonnablement regrouper sous un même vocable des jeunes qui n’ont rien de commun du point de vue de leurs origines sociales et de leurs ethos de classe.
Innowacyjność w edukacji językowej a profesjonalizm nauczyciela
Authors: Droździał-Szelest Krystyna 
Published: April 2019

Innovation in language education, just as in any other discipline, is connected with changes whose primary goal is to make the process of language learning/language teaching more efficient. Examples of such innovations include, for instance, task based instruction, computer assisted language learning or the use of portfolio as a means of assessment.Innovation implies a new, qualitatively different perception of the language learning/ language teaching process, roles of teachers and learners, use of materials etc., hence it is believed to constitute a challenge for language teachers and their professionalism. The present article is an attempt to answer the question whether and to what extent the language teaching profession is actually prepared to deal with innovation.
Die 1990er Jahre als Epochenschwelle? Der Umbau der Deutschland AG zwischen Traditionsbruch und Kontinuitätswahrung
Authors: Berghoff Hartmut 
Published: April 2019

Zusammenfassung
Dieser Aufsatz befasst sich mit den Umbrüchen der 1990er Jahre in der Wirtschaft der Bundesrepublik und fragt nach dem Verhältnis von Diskontinuität und Kontinuität. Ausgehend von der Diskussion um die „Varieties of Capitalism“ wird diskutiert, inwieweit sich der koordinierte Kapitalismus deutscher Spielart auflöste. Im Einzelnen werden die Deregulierung des Kapitalmarktes, die Finanzialisierung der Unternehmen und ihre zunehmende Plastizität sowie die Veränderungen von Management und Arbeitsbeziehungen thematisiert. Auch wenn sich tiefgreifende Umbrüche, insbesondere die Aushöhlung traditioneller Sicherheiten nachweisen lassen, löste sich die Deutschland AG keineswegs auf. Vielmehr nahm sie lediglich partiell Elemente des angelsächsischen Modells auf. Insgesamt flexibilisierte und modernisierte sie sich.
What can we learn from other countries—lessons from the CAJC Happiness Report
Authors: Roeth Anjali A. 
Published: April 2019

AbstractMost countries have their own programs and requirements for surgical residency. To investigate the differences as well as the advantages and disadvantages of the programs and to explore the happiness of the residents in the different countries, the Surgical Working Group of “Young Surgeons” of the German Society for General and Visceral Surgery has designed a questionnaire. It focuses on three parts: structural and legal requirements, operating room (OR)- and non-OR-related content of the program, and contentment of the residents. In this opinion paper, first the results are shared by the description of the programs in nine different countries. It is shown that the requirements to become a surgeon differ highly between the different countries. Nonetheless, a structured curriculum, the possibility of feedback or a surgical mentoring program, and transparency regarding the OR schedule seem to be important to all residents to reach job satisfaction.
The aqueous and methanol extracts of Bambusa vulgaris (Poaceae) improve calcium and phosphorus levels, and bone microstructure in ovariectomized model of osteoporosis
Authors: Watcho Pierre , Guiadem Kamto Kamto Bernadette , Defo Deeh Patrick Brice , Nguelefack Telesphore Benoit , Kamanyi Albert , Kamtchouing Pierre 
Published: April 2019

Abstract

Background
Osteoporosis represents the most common metabolic bone disease. Bambusa vulgaris (Poaceae) is a plant with potential antiosteoporotic effects, due to its phytoestrogenic, antioxidative, and anti-inflammatory properties. This study was undertaken to evaluate the effects of aqueous and methanol extracts of B. vulgaris on osteoporosis in rats.

Methods
Adult female Wistar rats were randomly divided into normal (n = 6) and ovariectomized (n = 42) groups. Twelve weeks after ovariectomy, animals were treated for 4 weeks as follows: distilled water (10 mL/kg, per os (p.o.)), 17β-estradiol (10 μg/kg, intraperitoneal (i.p.)), soya oil (1 mL/kg, i.p.), aqueous or methanol extract of B. vulgaris (55 or 110 mg/kg, p.o.). All rats were weighed daily and sacrificed on day 29. Plasma was collected, and the uterus and femur were dissected out, weighed, and used for biochemical and histological measurements.

Results
In the untreated ovariectomized females, a non-significant (p > 0.05) increase in body weight and a significant decrease (p < 0.001) in the uterine and bone weights were recorded. Ovariectomy also significantly (p < 0.001) lowered the bone calcium and phosphorus concentrations, and deteriorated the microarchitecture of the femur. Interestingly, B. vulgaris extracts significantly (p < 0.001) improved the bone calcium concentration and femur microarchitecture (increase in trabecular bone density, reorganization of the trabecular network, and increase in bone marrow) with estrogenic-like effects compared to 17β-estradiol.

Conclusion
These results suggest that B. vulgaris is a potential therapeutic drug for the treatment of osteoporosis. The present findings further justify the ethno-medicinal claims of B. vulgaris.