bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copper‐ Based Metal‐Organic Frameworks as Peroxidase Mimics Leading to Sensitive H2O2 and Glucose Detection
Authors: Menon Swetha S. , Chandran Soorya Valliparambil , Koyappayil Aneesh , Berchmans Sheela 
Published: July 2018

AbstractA copper based metal organic framework (MOF) synthesized under solvo‐thermal conditions was found to exhibit intrinsic peroxidase‐like activity and was established both spectrophotometrically and electrochemically. It was found that the catalytic behaviour had been consistent with Michaelis‐Menten kinetics with a Km value of 0.08 mM with H2O2, relatively lower than that of Horseradish peroxidase enzyme (HRP) ie; 3.7 mM. The suitability of Cu–MOF for sensing H2O2 was investigated by electrochemical means. In the case of electrochemical studies, the Cu–MOF modified GCE (glassy carbon electrode) showed a very high sensitivity of 263 μA mmol−1 cm−2 with a detection limit up to 35 mM for H2O2. The peroxidase mimics can be combined with the enzymatic oxidation of glucose for sensing glucose. The detection of H2O2 and glucose using Cu–MOF was found to be highly selective towards the common interfering species.
Green Synthesis, Antimicrobial Activity and Cytotoxicity of Novel Fused Pyrimidine Derivatives Possessing a Trifluoromethyl Moiety
Authors: Al‐Bogami Abdullah S. , Saleh Tamer S. , Moussa Tarek A. A. 
Published: July 2018

AbstractA series of novel fused pyrimidine derivatives possessing a trifluoromethyl moiety have been synthesized by the reaction of the enaminone named E‐3‐(dimethylamino)1‐(4‐(trifluoromethyl)phenyl)prop‐2‐en‐1‐one with a variety of heterocyclic amines under solvent free mechanochemical condition utilizing nano sized magnesium oxide catalyst. 1H–15N HMBC (Heteronuclear Multiple Bond Correlation) NMR technique was used to allow for the unambiguous structural characterization of the fused pyrimidine products. The newly synthesized fused pyrimidines were investigated for their antimicrobial and anticancer activity. A pronounced inhibitory effect on the growth of the tested cell lines was recorded by the examined newly synthesized fused pyrimidines.
Colloidal Stability of Lipid/Protein‐Coated Nanomaterials in Salt and Sucrose Solutions
Authors: Nobeyama Tomohiro , Mori Megumi , Shigyou Kazuki , Takata Koji , Pandian Ganesh N. , Sugiyama Hiroshi , Murakami Tatsuya 
Published: July 2018

AbstractConsidering the importance of surface chemistry in the colloidal stabilization of gold nanorods (AuNRs), we designed AuNRs in two physiologically relevant, salt and salt‐free aqueous solutions to validate its role in colloidal stability. Here, we show that AuNRs coated with cationic lipid/lipid‐binding protein composite materials is stable in both phosphate‐buffered saline (PBS) and sucrose solution (200 mM), but not in deionized water. Salting‐in effects of proteins explain the relatively better stability of AuNRs in PBS than in deionized water. Sucrose‐assisted stabilization of the AuNRs was associated with a decrease in their zeta potential and tended to diminish without the cationic lipid, which would be attributed to an electrostatic interaction between sucrose and the cationic lipid. Given that sucrose solution is often used for cell‐sized liposome studies, our finding will enable nanomaterial‐membrane interaction analyses in live cell and cell‐free systems with identical nanomaterials.
Efficient Solvent‐Free Friedel‐Crafts Benzoylation and Acylation of m‐Xylene Catalyzed by N‐Acetylpyrazine‐2‐carbohydrazide‐Fe(III)‐chloro Complexes
Authors: Barman Tannistha Roy , Sutradhar Manas , Alegria Elisabete C. B. A. , Guedes da Silva M. Fátima C. , Kuznetsov Maxim L. , Pombeiro Armando J. L. 
Published: July 2018

AbstractReaction of N‐acetylpyrazine‐2‐carbohydrazide (H2L) with anhydrous Fe(II) or Fe(III) chloride in CH3CN or in MeOH leads to the mononuclear [Fe(κNN'O‐HL)Cl2] (1) or binuclear [Fe(κNN'O‐HL)Cl(μ‐OMe)]2 (2) Fe(III) complex, respectively. These complexes are characterized by elemental analysis, ESI‐MS, IR spectroscopy, single‐crystal X‐ray crystallography, electrochemical techniques and DFT calculations. The theoretical calculations indicate that the three single‐electron sequential reductions of 1 are centred at the metal, at the pyrazine group and at both, respectively. The catalytic activity of 1 and 2 was screened towards Friedel‐Crafts benzoylation and acylation of m‐xylene. The effects of reaction parameters, such as catalyst amount, reaction time and temperature, were studied and, under optimal conditions, 96% yield of 2,4‐dimethylbenzophenone and 20% yield of 2,4‐dimethylacetophenone were obtained, respectively. Complex 1 exhibited the highest activity in both reactions. The structural and electrochemical properties were supported by theoretical calculations and the importance of the Lewis acid character of the catalyst in the promotion of this catalytic reaction is discussed.
Charophytes from the Cretaceous–Paleocene boundary in the Songliao Basin (north‐eastern China): a Chinese biozonation and its calibration to the Geomagnetic Polarity Time Scale
Authors: Li Sha , Wang Qifei , Zhang Haichun , Wan Xiaoqiao , Martín‐Closas Carles 
Published: July 2018

AbstractCharophyte assemblages from the mid‐Campanian and lower Paleocene of the SK‐1(North) borehole in the Songliao Basin (NE China) are here re‐studied. Four charophyte biozones and one superzone are defined in the Sifangtai and Mingshui formations and correlated to the Geomagnetic Polarity Time Scale. These include a mid–late Campanian Atopochara trivolvis ulanensis Zone, a latest Campanian – early Maastrichtian Microchara gobica Zone, a late Maastrichtian Microchara prolixa Zone, and an earliest Danian Peckichara sinuolata Zone. The latter three zones are grouped within the Microchara cristata Superzone, which allows intra‐ and intercontinental correlation with other basins in China and Europe. Peckichara sinuolata first appears in chron C29r (upper Mingshui Formation) and is proposed as the basal marker of the Paleocene. The biozonation of the K/Pg interval proposed for the Songliao Basin differs from a previous biozonation proposed in the Pingyi Basin since it represents a different biogeographical and palaeoecological context. In the mid‐Campanian to Maastrichtian, the flora was limited to freshwater lakes in northern China and Mongolia, whereas in the Pingyi Basin, brackish water dominated. In the Paleocene, the Songliao Basin contained a diverse flora consisting of nine species that thrived in terrigenous and temporary lakes, whereas the flora in the Pingyi Basin was dominated by one species inhabiting permanent alkaline lakes. The species common to the two basins are widely distributed in Eurasia and constitute a useful tool for long‐distance correlations, but serve as a less‐precise tool for detailed biostratigraphical subdivision within one specific basin.
Seismic performance analysis of viscous damping outrigger in super high‐rise buildings
Authors: Ding Jiemin , Wang Shiyu , Wu Honglei 
Published: July 2018

SummaryThis paper introduces a seismic energy dissipation technology—viscous damping outrigger (VDO)—which is composed of outrigger truss and viscous damper. The viscous damper is set up vertically at the end of outrigger truss, which is an innovative and high‐efficiency arrangement. VDO can fully utilize the characteristic of structural lateral deformation of super high‐rise buildings to increase the efficiency of viscous dampers for enhancing structural security, improving seismic performance, and reducing construction expenditure. In this paper, working principle and seismic energy dissipating mechanism of VDO are explained firstly. Then, the influence of viscous damper parameters on energy dissipation efficiency is studied. Next, the optimal position of VDO in a super high‐rise building is analyzed in detail. Lastly, the application of VDO in structural seismic design of a super high‐rise building in China will be clearly verified based on their feasibility, economy, and safety.
Technological reviews of particulate matter and their source identification techniques
Authors: Yadav Akhilesh Kumar , Jamal Aarif 
Published: July 2018

AbstractParticulate matter (PM) is one of the primary pollutants produced from mining operations. This paper summarizes the existing techniques used to identify sources of PM and their contribution to ambient air pollution. Human health studies indicate that there is an association between airborne PM and adverse health effects. Particularly in coal mining areas, the burning of coal and PM from machinery operations cause low air quality that is physically harmful. Thus, the sources of smoldering combustion, that are typical in coal mine burns, increase the risk to mine workers who are exposed to high concentrations of known toxicity associated with PM. Recent studies on the modeling of PM concentration profiles across various sources were reviewed for this paper.
Randomised controlled trial of the new short-term online emotion focused training for self-compassion and self-protection in a nonclinical sample
Authors: Halamová Júlia , Kanovský Martin , Varšová Karolína , Kupeli Nuriye 
Published: July 2018

AbstractThe Emotion Focused Training for Self-Compassion and Self-Protection (EFT-SCP) is an intervention developed to increase skills of self-compassion and protective anger with the aim to decrease self-criticism. This novel intervention was developed on the basis of the latest findings on self-criticism from Emotion-focused therapy and previous programs cultivating compassion (namely Compassion Mind Training and Mindful Self-Compassion Program). According to existing research, simply cultivating self-compassion is not always sufficient in reducing self-criticism. Therefore, the EFT-SCP was designed to build self-compassion whilst developing protective anger to combat self-criticism. Our goal was to investigate the efficacy of this new, short-term, online EFT-SCP program in a non-clinical population. A randomized control trial was conducted with pre- and post-intervention measurements and two-month follow-up of self-compassion and self-criticism/reassurance. Convenience sampling was used to recruit participants through a snowballing technique on social media. A total of 123 participants were randomly allocated to the EFT-SCP intervention or to a control condition. The intervention group were instructed through emails to complete an EFT-SCP task every day for 14 consecutive days. The control group did not complete any tasks. Out of 123 participants, 31 from intervention group and 20 from control group completed all measurements. There was a significant effect of the EFT-SCP on increasing self-compassion and self-reassurance scores as reported at two-month follow-up. The EFT-SCP was also effective at reducing self-uncompassionate responding and self-criticism (specifically Hated self) with changes evident at two months post-intervention. These findings are encouraging and suggest that interventions designed to enhance self-compassion and decrease self-criticism can be delivered to broader populations without the direct contact with mental health professionals.
Assessing Subgroup Differences in Posttraumatic Stress Disorder Among Rescue Workers in Japan With the Impact of Event Scale–Revised
Authors: Noda Yoshikazu , Asano Kenichi , Shimizu Eiji , Hirano Yoshiyuki 
Published: July 2018

ABSTRACTObjectiveWe examined the impact of demographic confounding factors on responses to the Impact of Event Scale–Revised.MethodsParticipants were rescue workers aged 20 to 65 years who had responded during the Great East Japan Earthquake in 2011. A multiple indicators, multiple causes model was used to examine associations between covariates and latent factors or items in the Impact of Event Scale–Revised.ResultsParticipants were recruited from April to August 2015. The model fit indices in the confirmatory factor analysis and the multiple indicators, multiple causes model suggested an acceptable model fit. Higher education and the Connor-Davidson Resilience Scale score were significantly associated with a decrease in intrusion, avoidance, and hyperarousal. Counseling was significantly associated with increased avoidance. In the direct path model using modification indices, counseling and early arrival were identified as significant covariates.ConclusionsThis study found that higher education and resilience reduced all 3 factors in the Impact of Event Scale–Revised and improved the symptoms of intrusion, avoidance, and hyperarousal. Counseling and early arrival were also associated with improvement in certain items. However, counseling was also linked to increased avoidance and worsening psychophysiological reactions. Further research is recommended to clarify these relationships. (Disaster Med Public Health Preparedness. 2019;13:309–318)
Patient contact is the main risk factor for vancomycin-resistant Enterococcus contamination of healthcare workers’ gloves and gowns in the intensive care unit
Authors: Jackson Sarah S. , Thom Kerri A. , Magder Laurence S. , Stafford Kristen A. , Johnson J. Kristie , Miller Loren G. , Calfee David P. , Harris Anthony D. ,   for the CDC Prevention Epicenters Program
Published: July 2018

AbstractObjectiveTo determine which healthcare worker (HCW) roles and patient care activities are associated with acquisition of vancomycin-resistant Enterococcus (VRE) on HCW gloves or gowns after patient care, as a surrogate for transmission to other patients.DesignProspective cohort study.SettingMedical and surgical intensive care units at a tertiary-care academic institution.ParticipantsVRE-colonized patients on Contact Precautions and their HCWs.MethodsOverall, 94 VRE-colonized patients and 469 HCW–patient interactions were observed. Research staff recorded patient care activities and cultured HCW gloves and gowns for VRE before doffing and exiting patient room.ResultsVRE were isolated from 71 of 469 HCWs’ gloves or gowns (15%) following patient care. Occupational/physical therapists, patient care technicians, nurses, and physicians were more likely than environmental services workers and other HCWs to have contaminated gloves or gowns. Compared to touching the environment alone, the odds ratio (OR) for VRE contamination associated with touching both the patient (or objects in the immediate vicinity of the patient) and environment was 2.78 (95% confidence interval [CI], 0.99–0.77) and the OR associated with touching only the patient (or objects in the immediate vicinity) was 3.65 (95% CI, 1.17–11.41). Independent risk factors for transmission of VRE to HCWs were touching the patient’s skin (OR, 2.18; 95% CI, 1.15–4.13) and transferring the patient into or out of bed (OR, 2.66; 95% CI, 1.15–6.43).ConclusionPatient contact is a major risk factor for HCW contamination and subsequent transmission. Interventions should prioritize contact precautions and hand hygiene for HCWs whose activities involve touching the patient.
Observer-rated retardation but not agitation corresponds to objective motor measures in depression
Authors: van Diermen Linda , Walther Sebastian , Cools Olivia , Fransen Erik , Birkenhäger Tom K. , Sabbe Bernard C.G. , Schrijvers Didier 
Published: July 2018

AbstractObjectiveTo explore the correlations between observer ratings and instrumental parameters across domains of psychomotor functioning in depression.MethodIn total, 73 patients with major depressive disorder underwent extensive psychomotor and clinical testing. Psychomotor functioning was assessed with (i) an observer-rated scale (the CORE measure) and also objectively with (ii) 24-h actigraphy, and (iii) a fine motor drawing task.ResultsObserver ratings of retardation correlated with instrumental assessments of fine and gross motor functioning. In contrast, observer ratings of agitation did not correlate with observer ratings of retardation or with the instrumental measures. These associations were partly influenced by age and, to a lesser extent, by depression severity.ConclusionPsychomotor disturbance is a complex concept with different manifestations in depressed patients. Although observer ratings of retardation correspond well with instrumental measures of the motor domains, objective measurement of agitation and other aspects of psychomotor disturbance require further research.
Maternal traditional dietary pattern and antiretroviral treatment exposure are associated with neonatal size and adiposity in urban, black South Africans
Authors: Wrottesley Stephanie V. , Ong Ken K. , Pisa Pedro T. , Norris Shane A. 
Published: July 2018

AbstractThis study examines the associations between maternal Traditional dietary pattern adherence and HIV/treatment with neonatal size and adiposity in urban, black South Africans, as well as how specific maternal factors – that is BMI and gestational weight gain (GWG) – may influence these associations. Multiple linear regression models were used to examine associations among maternal Traditional diet pattern adherence (pattern score), HIV/treatment status (three groups: HIV negative, HIV positive (antenatal antiretroviral treatment (ART) initiation), HIV positive (pre-pregnancy ART initiation)), BMI and GWG (kg/week), and newborn (1) weight:length ratio (WLR, kg/m) in 393 mother–neonate pairs, and (2) Peapod estimated fat mass index (FMI, kg/m3) in a 171-pair subsample. In fully adjusted models, maternal obesity and GWG were associated with 0·25 kg/m (P=0·008) and 0·48 kg/m (P=0·002) higher newborn WLR, whereas Traditional diet pattern score was associated with lower newborn WLR (−0·04 kg/m per +1sd;P=0·033). In addition, Traditional diet pattern score was associated with 0·13 kg/m3(P=0·027) and 0·32 kg/m3(P=0·005) lower FMI in the total sample and in newborns of normal-weight women, respectively. HIV-positive (pre-pregnancy ART)v. HIV-negative (ref) status was associated with 1·11 kg/m3(P=0·002) higher newborn FMI. Promotion of a Traditional dietary pattern, alongside a healthy maternal pre-conception weight, in South African women may reduce newborn adiposity and metabolic risk profiles. In HIV-positive women, targeted monitoring and management strategies are necessary to limit treatment-associated effects onin uterofat deposition.
Don't characterize replications as successes or failures
Authors: Gelman Andrew 
Published: July 2018

AbstractNo replication is truly direct, and I recommend moving away from the classification of replications as “direct” or “conceptual” to a framework in which we accept that treatment effects vary across conditions. Relatedly, we should stop labeling replications as successes or failures and instead use continuous measures to compare different studies, again using meta-analysis of raw data where possible.
Why replication has more scientific value than original discovery
Authors: Ioannidis John P. A. 
Published: July 2018

AbstractThe presumed dominance of “original discovery” over replication is an anomaly. Original discovery has more value than replication primarily when scientific investigation can immediately generate numerous discoveries most of which are true and accurate. This scenario is uncommon. A model shows how original discovery claims typically have small or even negative value. Science becomes worthy mostly because of replication.
Selecting target papers for replication
Authors: Kuehberger Anton , Schulte-Mecklenbeck Michael 
Published: July 2018

AbstractRandomness in the selection process of to-be-replicated target papers is critical for replication success or failure. If target papers are chosen because of the ease of doing a replication, or because replicators doubt the reported findings, replications are likely to fail. To date, the selection of replication targets is biased.
Constraints on generality statements are needed to define direct replication
Authors: Simons Daniel J. , Shoda Yuichi , Lindsay D. Stephen 
Published: July 2018

AbstractWhether or not a replication attempt counts as “direct” often cannot be determined definitively after the fact as a result of flexibility in how procedural differences are interpreted. Specifying constraints on generality in original articles can eliminate ambiguity in advance, thereby leading to a more cumulative science.
Interdependent policy instrument preferences: a two-mode network approach
Authors: Metz Florence , Leifeld Philip , Ingold Karin 
Published: July 2018

AbstractIn policymaking, actors are likely to take the preferences of others into account when strategically positioning themselves. However, there is a lack of research that conceives of policy preferences as an interdependent system. In order to analyse interdependencies, we link actors to their policy preferences in water protection, which results in an actor-instrument network. As actors exhibit multiple preferences, a complex two-mode network between actors and policies emerges. We analyse whether actors exhibit interdependent preference profiles given shared policy objectives or social interactions among them. By fitting an exponential random graph model to the actor-instrument network, we find considerable clustering, meaning that actors tend to exhibit preferences for multiple policy instruments in common. Actors tend to exhibit interdependent policy preferences when they are interconnected, that is, they collaborate with each other. By contrast, actors are less likely to share policy preferences when a conflict line divides them.
Cost-effectiveness ofHelicobacter pyloriscreening followed by eradication treatment for employees in Japan
Authors: Kowada A. 
Published: July 2018

AbstractGastric cancer is the third leading cause of cancer death worldwide. Gastric cancer screening using upper gastrointestinal series, endoscopy and serological testing has been performed in population-based (employee-based and community-based) and opportunistic cancer screening in Japan. There were 45 531 gastric cancer deaths in 2016, with the low screening and detection rates.Helicobacter pylori(H. pylori) screening followed by eradication treatment is recommended in high-risk population settings to reduce gastric cancer incidence. The aim of this study was to evaluate the cost-effectiveness ofH. pyloriscreening followed by eradication treatment for a high-risk population in the occupational health setting. Decision trees and Markov models were developed for two strategies;H. pyloriantibody test (HPA) screening and no screening. Targeted populations were hypothetical cohorts of employees aged 20, 30, 40, 50 and 60 years using a company health payer perspective on a lifetime horizon. Per-person costs and effectiveness (quality-adjusted life-years) were calculated and compared. HPA screening yielded greater benefits at the lower cost than no screening. One-way and probabilistic sensitivity analyses using Monte-Carlo simulation showed strong robustness of the results.H. pyloriscreening followed by eradication treatment is recommended to prevent gastric cancer for employees in Japan, on the basis of cost-effectiveness.