bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing community awareness and participation in health facility governing committees in two districts of Tanzania: a cross-sectional study
Authors: Kapuya Hussein Athuman , Maluka Stephen Oswald , Hurtig Anna-Karin , Sebastian Miguel San 
Published: October 2024

Abstract
Background
Tanzania has been promoting community participation in health, either directly or through health facility governing committees (HFGCs), as part of its wider, ongoing health system reforms since the 1990s. Although some studies have assessed the functioning of the HFGCs, little is known about community knowledge and involvement in their activities.

Methods
A cross-sectional survey assessing community awareness and participation in HFGCs was conducted between July and October 2022, involving two rural districts of Tanzania, which were selected based on their performance: Handeni, showing low performance and Mbarali, high performance. A total of 1,184 household heads living in the catchment areas of diverse facilities were involved. Frequencies and percentages were calculated overall and by district. The Chi-squared test was applied to assess statistically significant differences in knowledge, awareness, and participation between the districts.

Results
The results revealed that 85.3% of the participants were unaware of the presence of the HFGCs and 91.7% did not know their roles. Additionally, 87% had neither heard nor seen any announcement about the selection of committee members. Only 14.5% considered that HFGCs were accountable to the community. While 96.7% of the respondents said they had never received any feedback from the HFGCs, only 8.1% reported that HFGCs were collecting views from the community. Regarding participation, 79.9% believed that the community had not been supporting their activities; however, 44.7% believed that the committees were important in improving health service delivery. Feedback and support were more common in Handeni.

Conclusion
The level of community awareness of and participation in HFGCs was very low in both districts. The Ministry of Health and the President’s Office of Regional Administration and Local Government should implement an action plan to raise community awareness of the role of the HFGCs and their significance in promoting social accountability within the Tanzanian health system.
Hemorrhages and risk factors in patients undergoing thromboprophylaxis in a respiratory critical care unit: a secondary data analysis of a cohort study
Authors: Lyu Wen‐Rui , Tang Xiao , Jin Yu , Wang Rui , Li Xu‐Yan , Li Ying , Zhang Chun‐Yan , Zhao Wei , Tong Zhao‐Hui , Sun Bing 
Published: October 2024

Abstract
Objective
To verify whether the bleeding risk assessment guidelines from the 9th American College of Chest Physicians (ACCP) are prognostic for respiratory intensive care unit (RICU) patients and to explore risk factors for hemorrhages, we conducted a secondary data analysis based on our previously published cohort study of venous thromboembolism.

Patients and methods
We performed a secondary data analysis on the single-center prospective cohort from our previous study. Patients admitted to the RICU at Beijing Chao-Yang Hospital from August 1, 2014 to December 31, 2020 were included and followed up until discharge.

Results
The study enrolled 931 patients, of which 715 (76.8%) were at high risk of bleeding, while the remaining were at low risk. Of the total, 9.2% (86/931) suffered major bleeding, and no significant difference was found between the two risk groups (p = 0.601). High-risk patients had poor outcomes, including higher mortality and longer stays. Independent risk factors for major bleeding were APACHE II score ≥ 15; invasive pulmonary aspergillosis; therapeutic dose of anticoagulants; extracorporeal membrane oxygenation; and continuous renal replacement therapy. Blood transfusion not related to bleeding appeared to be an independent protective factor for major bleeding (OR 0.099, 95% CI 0.045–0.218, p < 0.001).

Conclusion
Bleeding risk assessment models from the 9th ACCP guidelines may not be suitable for patients in RICU. Building a bleeding risk assessment model that is suitable for patients in all RICUs remains a challenge.
Trial registration ClinicalTrials.gov: NCT02213978.
Serum DLK1 During Minipuberty and Pubertal Transition in Healthy Girls and in Girls With Precocious Puberty
Authors: Vilmann Lea , Sørensen Kaspar , Busch Alexander S , Ljubicic Marie L , Upners Emmie N , Fischer Margit B , Johannsen Trine H , Holmboe Stine A , Juul Anders , Hagen Casper P 
Published: October 2024

Abstract

Context
Delta-like non-canonical notch ligand 1 (DLK1) is negatively associated with bodyweight. DLK1 pathogenic variants cause central precocious puberty (CPP) and obesity, suggesting that DLK1 links the well-established association between higher body mass index and earlier pubertal onset. However, little is known about the trajectories of circulating DKL1 in healthy girls as well as in girls with precocious puberty.

Objective
To evaluate longitudinal changes in circulating DLK1 concentrations in (1) full-term, singleton healthy infant girls, (2) healthy girls during pubertal transition, and (3) girls with CPP during treatment with gonadotropin-releasing hormone agonist (GnRHa).

Methods
Three longitudinal studies of (1) healthy infant girls (n = 85), (2) healthy peripubertal girls (n = 15), and (3) girls with CPP before and after GnRHa treatment (n = 15). Body fat percentage calculated using the Slaughter equation, and serum concentrations of DLK1 using enzyme-linked immunosorbent assay.

Results
Serum concentration of DLK1 in healthy infant girls declined significantly through the first year of life (17.6 to 9.9 ng/mL, P = .020). DLK1 was inversely correlated with birth weight and BF%: r = −0.220, P = .044, and r = −0.503, P &lt; .001, respectively. DLK1 declined from 1 year prior to pubertal onset to time of first examination after pubertal onset (10.4  to 9.2 ng/mL, P = .004), as well as to time at the last pubertal evaluation (10.4 to 9.8 ng/mL, P = .006). DLK1 levels were not affected by GnRHa treatment.

Conclusion
Circulating DLK1 levels declined steeply during infancy and were less pronounced through pubertal development. Due to considerable interindividual variation, DLK1 is not useful as a diagnostic marker of pubertal onset. Importantly, DLK1 was negatively associated with birth weight and body fat percentage.
SMPD4-mediated sphingolipid metabolism regulates brain and primary cilia development
Authors: Inskeep Katherine A. , Crase Bryan , Dayarathna Thamara , Stottmann Rolf W. 
Published: October 2024

ABSTRACT
Genetic variants in multiple sphingolipid biosynthesis genes cause human brain disorders. A recent study looked at people from 12 unrelated families with variants in the gene SMPD4, a neutral sphingomyelinase that metabolizes sphingomyelin into ceramide at an early stage of the biosynthesis pathway. These individuals have severe developmental brain malformations, including microcephaly and cerebellar hypoplasia. The disease mechanism of SMPD4 was not known and so we pursued a new mouse model. We hypothesized that the role of SMPD4 in producing ceramide is important for making primary cilia, a crucial organelle mediating cellular signaling. We found that the mouse model has cerebellar hypoplasia due to failure of Purkinje cell development. Human induced pluripotent stem cells lacking SMPD4 exhibit neural progenitor cell death and have shortened primary cilia, which is rescued by adding exogenous ceramide. SMPD4 production of ceramide is crucial for human brain development.
A neuro-lymphatic communication guides lymphatic development by CXCL12 and CXCR4 signaling
Authors: Do Long Nguyen Hoang , Delgado Esteban , Lim Casey G. , Bkhache Meriem , Peluzzo Amanda M. , Hua Yiming , Oza Manisha , Mohsin Sadia , Chen Hong , Autieri Michael V. , Kim Seonhee , Liu Xiaolei 
Published: October 2024

ABSTRACT
Lymphatic vessels grow through active sprouting and mature into a vascular complex that includes lymphatic capillaries and collecting vessels that ensure fluid transport. However, the signaling cues that direct lymphatic sprouting and patterning remain unclear. In this study, we demonstrate that chemokine signaling, specifically through CXCL12 and CXCR4, plays crucial roles in regulating lymphatic development. We show that LEC-specific Cxcr4-deficient mouse embryos and CXCL12 mutant embryos exhibit severe defects in lymphatic sprouting, migration and lymphatic valve formation. We also discovered that CXCL12, originating from peripheral nerves, directs the migration of dermal lymphatic vessels to align with nerves in developing skin. Deletion of Cxcr4 or blockage of CXCL12 and CXCR4 activity results in reduced VEGFR3 levels on the LEC surface. This, in turn, impairs VEGFC-mediated VEGFR3 signaling and downstream PI3K and AKT activities. Taken together, these data identify previously unknown chemokine signaling originating from peripheral nerves that guides dermal lymphatic sprouting and patterning. Our work identifies for the first time a neuro-lymphatics communication during mouse development and reveals a previously unreported mechanism by which CXCR4 modulates VEGFC, VEGFR3 and AKT signaling.
Germ cell progression through zebrafish spermatogenesis declines with age
Authors: Sposato Andrea L. , Hollins Hailey L. , Llewellyn Darren R. , Weber Jenna M. , Schrock Madison N. , Farrell Jeffrey A. , Gagnon James A. 
Published: October 2024

ABSTRACT
Vertebrate spermatogonial stem cells maintain sperm production over the lifetime of an animal, but fertility declines with age. Although morphological studies have informed our understanding of typical spermatogenesis, the molecular and cellular mechanisms underlying the maintenance and decline of spermatogenesis are not yet understood. We used single-cell RNA sequencing to generate a developmental atlas of the aging zebrafish testis. All testes contained spermatogonia, but we observed a progressive decline in spermatogenesis that correlated with age. Testes from some older males only contained spermatogonia and a reduced population of spermatocytes. Spermatogonia in older males were transcriptionally distinct from spermatogonia in testes capable of robust spermatogenesis. Immune cells including macrophages and lymphocytes drastically increased in abundance in testes that could not complete spermatogenesis. Our developmental atlas reveals the cellular changes as the testis ages and defines a molecular roadmap for the regulation of spermatogenesis.
On Interdicting Dense Clusters in a Network
Authors: Zhong Haonan , Mahdavi Pajouh Foad , Butenko Sergiy , Prokopyev Oleg A. 
Published: October 2024

Given a vertex-weighted undirected graph with blocking costs of its vertices and edges, we seek a minimum cost subset of vertices and edges to block such that the weight of any γ-quasi-clique in the interdicted graph is at most some predefined threshold parameter. The value of [Formula: see text] specifies the edge density of cohesive vertex groups of interest in the network. The considered weighted γ-quasi-clique interdiction problem can be viewed as a natural generalization of several variations of the clique blocker problem previously studied in the literature. From the application perspective, this setting is primarily motivated by the problem of disrupting adversarial (“dark”) networks (e.g., social or communication networks), where γ-quasi-cliques represent “tightly knit” groups of adversaries that we aim to dismantle. We first address the theoretical computational complexity of the problem. We then exploit some basic characterization of its feasible solutions to derive a linear integer programming (IP) formulation. This linear IP model can be solved using a lazy-fashioned branch-and-cut scheme. We also propose a combinatorial branch-and-bound algorithm for solving this problem. The computational performance of the developed exact solution schemes is studied using a test bed of randomly generated and real-life networks. Finally, some interesting insights and observations are also provided using a well-known example of a terrorist network. History: Accepted by Russel Bent, Area Editor for Network Optimization: Algorithms & Applications. Funding: The work of S. Butenko was partially supported by the Air Force Office of Scientific Research under Award FA9550-23-1-0300. The work of O. A. Prokopyev was partially supported by the Office of Naval Research under Award ONR N00014-22-1-2678. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.0027 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0027 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ . The online appendix is available at https://doi.org/10.1287/ijoc.2023.0027 .
Efficient Implementation of Interior-Point Methods for Quantum Relative Entropy
Authors: Karimi Mehdi , Tunçel Levent 
Published: October 2024

Quantum relative entropy (QRE) programming is a recently popular and challenging class of convex optimization problems with significant applications in quantum computing and quantum information theory. We are interested in modern interior-point (IP) methods based on optimal self-concordant barriers for the QRE cone. A range of theoretical and numerical challenges associated with such barrier functions and the QRE cones have hindered the scalability of IP methods. To address these challenges, we propose a series of numerical and linear algebraic techniques and heuristics aimed at enhancing the efficiency of gradient and Hessian computations for the self-concordant barrier function, solving linear systems, and performing matrix-vector products. We also introduce and deliberate about some interesting concepts related to QRE such as symmetric quantum relative entropy. We design a two-phase method for performing facial reduction that can significantly improve the performance of QRE programming. Our new techniques have been implemented in the latest version (DDS 2.2) of the software package Domain-Driven Solver (DDS). In addition to handling QRE constraints, DDS accepts any combination of several other conic and nonconic convex constraints. Our comprehensive numerical experiments encompass several parts, including (1) a comparison of DDS 2.2 with Hypatia for the nearest correlation matrix problem, (2) using DDS 2.2 for combining QRE constraints with various other constraint types, and (3) calculating the key rate for quantum key distribution (QKD) channels and presenting results for several QKD protocols. History: Accepted by Giacomo Nannicini, Area Editor for Quantum Computing and Operations Research. Accepted for Special Issue. Funding: This work was supported by the National Science Foundation [Grant CMMI-2347120] and Discovery Grants from the Natural Sciences and Engineering Research Council of Canada. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2024.0570 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2024.0570 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Measuring Investor Attention Using Google Search
Authors: deHaan Ed , Lawrence Alastair , Litjens Robin 
Published: October 2024

Although investor attention is fundamental to the efficient functioning of capital markets, it is also an elusive construct that researchers struggle to measure. In recent years, the search volume index (SVI) of ticker searches on Google has become a ubiquitous measure of investor attention, but the amount and effects of measurement error in ticker SVI are unknown. We investigate measurement error in ticker SVI using a data set of 2.7 billion website visits following Standard and Poor’s 500 firms’ ticker searches. We find that 69% of searches are unrelated to investing, that this measurement error is highly correlated with firm characteristics, and that this measurement error can easily generate false-positive or false-negative results in common settings. We go on to show that a modified version of SVI using both a firm’s ticker and the word “stock” (e.g., searches for “CAT stock,” which we label “ticker-stock SVI”) not only better captures the search terms that investors typically use, but also has considerably less measurement error that is largely uncorrelated with observable firm characteristics. Ticker-stock SVI produces better specified tests, and although researchers must still carefully consider the effects of measurement error, we recommend that ticker-stock SVI is used in place of ticker SVI in most settings. We provide a data set of ticker-stock SVI to facilitate future work. This paper was accepted by Suraj Srinivisan, accounting. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.02174 . TS-SVI for the Russell 3000 is available for download at: github.com/robinlitjens/GoogleTickerStock-SVI and will be updated annually.
A 0/1 Constrained Optimization Solving Sample Average Approximation for Chance Constrained Programming
Authors: Zhou Shenglong , Pan Lili , Xiu Naihua , Li Geoffrey Ye 
Published: October 2024

Sample average approximation (SAA) is a tractable approach for dealing with chance constrained programming, a challenging stochastic optimization problem. The constraint of SAA is characterized by the 0/1 loss function, which results in considerable complexities in devising numerical algorithms. Most existing methods have been devised based on reformulations of SAA, such as binary integer programming or relaxed problems. However, the development of viable methods to directly tackle SAA remains elusive, let alone providing theoretical guarantees. In this paper, we investigate a general 0/1 constrained optimization, providing a new way to address SAA rather than its reformulations. Specifically, starting with deriving the Bouligand tangent and Fréchet normal cones of the 0/1 constraint, we establish several optimality conditions. One of them can be equivalently expressed by a system of equations, enabling the development of a semismooth Newton-type algorithm. The algorithm demonstrates a locally superlinear or quadratic convergence rate under standard assumptions along with nice numerical performance compared with several leading solvers. Funding: This research was supported by the National Key R&D Program of China [Grant 2023YFA1011100], the Fundamental Research Funds for the Central Universities, and the National Natural Science Foundation of China [Grant 12271309].
Realization of multi-transverse-mode squeezed optical frequency combs with Gouy phase compensation
Authors: Liu Peng , Li Juan , Li Xinghua , Xiang Xiao , Wang Shaofeng , Liu Tao , Cao Mingtao , Zhang Shougang , Cai Yin , Dong Ruifang 
Published: October 2024

Multimode quantum light fields significantly enhance quantum state manipulation and communication capabilities by expanding the dimensionality of the Hilbert space. In this work, we elaborately design a non-horizontal cavity suitable for a Gouy phase-compensated synchronously pumped optical parametric oscillator. By injecting an optical frequency comb in HG10 mode into the cavity as the seed, we demonstrate the simultaneous generation of a bright squeezed optical frequency comb in HG10 mode and a vacuum squeezed optical frequency comb in HG01 mode. The coexistence of amplitude quadrature squeezed fields in these two orthogonal first-order Hermite-Gaussian transverse modes also suggest the presence of quadrature entanglement between the two first-order Laguerre-Gaussian modes, LG0 + 1 and LG0 - 1. This research underscores the capability of one-step generation of multi-transverse-mode squeezed optical frequency combs using a single cavity, marking a significant stride in the realm of quantum optics.
LncRNA MALAT1 as diagnostic and prognostic biomarker in colorectal cancers: A systematic review and meta-analysis
Authors: Masrour Mahdi , Khanmohammadi Shaghayegh , Habibzadeh Amirhossein , Fallahtafti Parisa 
Published: October 2024

Objective
This study investigated the relationship between the long non-coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) expression and colorectal cancer (CRC) using a thorough systematic review and meta-analysis.

Methods
Under the PRISMA guidelines, a systematic review was conducted on studies published from the databases’ inception to September 18, 2023. Prognostic value and diagnostic accuracy were explored. Additionally, the association between levels of MALAT1 expression and pathological features was investigated. The statistical analysis was performed using the “meta” package of R.

Results
Among the pathological parameters examined, based on three studies involving 51 cases of metastatic CRC and 135 cases of non-metastatic CRC, a statistically significant correlation was found between the expression level of MALAT1 and distant metastasis, with an OR of 16.0118 (95% CI: 4.5618–56.2015). Three studies involving 378 cases reported overall survival and had a pooled HR of 2.3854 (95% CI: 1.3272–4.2875). Three studies involving 436 cases reported disease-free survival and had a pooled HR of 2.4772 (95% CI: 1.3774–4.4549). All prognosis studies utilized tumor tissue samples as specimens to assess the expression level of MALAT1. Case-to-control diagnostic studies with 126 cases and 126 controls had a pooled AUC value of 0.6173 (95% CI: 0.5436–0.6909), a pooled sensitivity of 0.675 (95% CI: 0.324–0.900), and a pooled specificity of 0.771 (95% CI: 0.685–0.839).

Conclusions
The expression of MALAT1 in CRC is highly correlated with distant metastasis and has an impact on survival and prognosis. MALAT1 could also be employed as a diagnostic biomarker. More prospective studies should be performed to assess the MALAT1 diagnostic potential in the early stages of CRC.
Relationship between customer knowledge management and the value co-creation of fitness application customers: Mediating role of flow experience
Authors: Wang Chao , Wang Zhigang , Liu Liandi , Hua Kai 
Published: October 2024

Purpose
This study examined the impacts of customer knowledge management and flow experience on customer value co-creation and the mediating role of flow experience in the context of fitness apps.

Design/methodology/approach
Using the questionnaire star platform to edit the questionnaire and collect data(n = 450). A structural equation modeling test was conducted to examine the relationships between the variables.

Findings
The findings reveal that in a fitness app service scenario, customer knowledge management has a significant positive impact on customer flow experience, customer flow experience has a significant positive impact on customer value co-creation, and customer flow experience plays a partial mediating role in the path from customer knowledge management to customer value co-creation.

Practical implications
The results could help fitness-app-related enterprises or service organizations understand the factors influencing and processes of customer participation in value co-creation and thus could help such enterprises and organizations formulate effective marketing strategies to realize customer value co-creation and ultimately to achieve their development goals.

Originality/value
Using value co-creation theory and customer-dominant logic, this study analyzed the effects of customer knowledge management, flow experience, and customer value co-creation in the context of fitness apps and examined the mediating role of flow experience. The findings fill a gap in the theoretical research regarding customer value co-creation in the context of fitness apps and expand the scope of research on customer knowledge management and flow experience.