bluuebunny/crossref_metadata_2025_split huggingface dataset:
The historical present in Spanish and semantic/pragmatic structure
Authors: Benavides Carlos 
Published: March 2019

AbstractThe historical present (HP) is the use of the present tense to refer to past events, usually as part of a narrative. Most work on this topic has dealt with the functions of English HP, mainly within the context of tense switching in conversational narrative. Relatively little work focuses exclusively on HP in Spanish, and most of it deals with the function of HP in conversational narratives. There is a gap in the literature regarding the specific interaction between the semantics and pragmatics involved in the use of HP, especially with respect to the formal representation of this interaction. In order to fill this gap, this paper analyzes the use of HP within the Parallel Architecture framework (Jackendoff 2002) and examines the implications for the semantic/pragmatic structure. Language samples produced by native speakers of Spanish and data from a large Spanish corpus are used as part of the basis for analysis. The present study also explores how the use of the preterite and imperfect in narrative in the past parallels the use of the simple present and the present progressive in narrative within the present timeframe, and shows how this can also be fruitfully analyzed employing the Parallel Architecture. The result is an original model that extends the formal apparatus of the Parallel Architecture to an area where it has not been applied before, the interface between semantics and narrative structure.
Searches and clicks in Peninsular Spanish
Authors: Pinto Derrin , Vigil Donny 
Published: March 2019

Abstract
The current study analyzes the use of click sounds in Peninsular Spanish with a focus on those that occur when
speakers are searching for what to say and signaling a particular stance. The data corpus consists of interviews with 18 speakers
from Spain who produce a total of 281 clicks. We consider clicks to be a non-lexical discourse marker that conveys information to
the listener regarding how an utterance should be interpreted. By applying a discourse-pragmatic approach from both quantitative
and qualitative perspectives, we examine contextual and co-textual factors that co-occur with the click and contribute to a
multimodal display consisting of pauses, fillers, repetitions, prolongations, gestures and object of search. The quantitative
results indicate some statistically significant differences with regard to how clicks interact with the linguistic and
extralinguistic environments. Qualitatively, we show evidence supporting the idea that clicks are part of a larger multimodal
communicative activity.
‘Monitoring’ in translation
Authors: Schaeffer Moritz J. , Halverson Sandra L. , Hansen-Schirra Silvia 
Published: March 2019

Abstract
We assume that visual feedback from the written trace during translation plays an important role in monitoring the
emerging translation. In this study, 44 participants translated with and without visual feedback from the target text (TT).
Numerous measures were used to explore the differences between the texts that were created in the two conditions and the
characteristics of the task performance in the two conditions. The impact of ST-TT semantic and syntactic relationships showed
that there were differences on two of three behavioural measures across conditions. In the comparison of features of the
translation process, findings show that ST reading times were longer without visual feedback, while increased translational choice
(implying more monitoring) affected eye movements on the source text (ST) in the same way in both conditions. We found that,
without visual feedback, when faced with more translational options, translators read the ST less linearly. Participants were more
likely to look at the TT screen or read the TT the longer they read the ST and the more the more translational options the ST
offered, even if the TT window was blank.
Clusters of water governance problems and their effects on policy delivery
Authors: Kirschke Sabrina , Franke Christian , Newig Jens , Borchardt Dietrich 
Published: March 2019

AbstractPublic policy problems are increasingly being characterised as wicked or tame problems, assuming that this classification is also meaningful for attempts to effective problem-solving. But do distinct ‘wicked’ or ‘tame’ problems empirically exist? We investigate 37 water-related problems in Germany, based on interview-based data on problem wickedness and official data on policy delivery. Our analysis clearly reveals four clusters of water governance problems (system complexity, uncertainty, tame and wicked problems), based on variations of three factors of wickedness (goals, uncertainty and system complexity). These clusters of problems vary in their effects on different dimensions of policy delivery (goal formulation, stages and degrees of implementation of measures), with significant effects on goal formulation and the number of measures ‘in construction’. These empirical insights may contribute to a more systematic design of governance strategies for addressing water governance problems in practice.
Driven probe under harmonic confinement in a colloidal bath
Authors: Démery Vincent , Fodor Étienne 
Published: March 2019

Abstract
Colloids held by optical or magnetic tweezers have been used to explore the local rheological properties of a complex medium and to extract work from fluctuations with some appropriate protocols. However, a general theoretical understanding of the interplay between the confinement and the interaction with the environment is still lacking. Here, we explore the statistical properties of the position of a probe confined in a harmonic trap moving at constant velocity and interacting with a bath of colloidal particles maintained at a different temperature. Interactions among particles are accounted for by a systematic perturbation, whose range of validity is tested against direct simulations of the full dynamics. Overall, our results provide a way to predict the effect of the driving and the environment on the probe, and can potentially be used to investigate the properties of colloidal heat engines with many-body interactions.
Facelift Part I: History, Anatomy, and Clinical Assessment
Authors: Hashem Ahmed M , Couto Rafael A , Duraes Eliana F R , Çakmakoğlu Çagri , Swanson Marco , Surek Chris , Zins James E 
Published: March 2019

AbstractIn this article, the authors aim to thoroughly describe the critical surgical anatomy of the facial layers, the retaining ligamentous attachments of the face, and the complex three-dimensional course of the pertinent nerves. This is supplemented with clarifying anatomic dissections and artwork figures whenever possible to enable easy, sound, and safe navigation during surgery. The historic milestones that led the evolution of cervicofacial rejuvenation to the art we know today are summarized at the beginning, and the pearls of the relevant facial analysis that permit accurate clinical judgment and hence individualized treatment strategies are highlighted at the end. The facelift operation remains the cornerstone of face and neck rejuvenation. Despite the emergence of numerous less invasive modalities, surgery continues to be the most powerful and more durable technique to modify facial appearance. All other procedures designed to ameliorate facial aging are either built around or serve as adjuncts to this formidable craft.
Response envelope analysis for quantitative evaluation of drug combinations
Authors: Du Di , Chang Chia-Hua , Wang Yumeng , Tong Pan , Chan Wai Kin , Chiu Yulun , Peng Bo , Tan Lin , Weinstein John N , Lorenzi Philip L 
Published: March 2019

Abstract

Motivation
The concept of synergy between two agents, over a century old, is important to the fields of biology, chemistry, pharmacology and medicine. A key step in drug combination analysis is the selection of an additivity model to identify combination effects including synergy, additivity and antagonism. Existing methods for identifying and interpreting those combination effects have limitations.

Results
We present here a computational framework, termed response envelope analysis (REA), that makes use of 3D response surfaces formed by generalized Loewe Additivity and Bliss Independence models of interaction to evaluate drug combination effects. Because the two models imply two extreme limits of drug interaction (mutually exclusive and mutually non-exclusive), a response envelope defined by them provides a quantitatively stringent additivity model for identifying combination effects without knowing the inhibition mechanism. As a demonstration, we apply REA to representative published data from large screens of anticancer and antibiotic combinations. We show that REA is more accurate than existing methods and provides more consistent results in the context of cross-experiment evaluation.

Availability and implementation
The open-source software package associated with REA is available at: https://github.com/4dsoftware/rea.

Supplementary information
Supplementary data are available at Bioinformatics online.
Extended-arch repair for acute type-A aortic dissection: perioperative and mid-term results
Authors: Fichadiya Akash , Gregory Alexander J , Kotha Vamshi K , Herget Eric J , Smith Holly N , Tai Elizabeth , Guo Ming , Mina Fady , Appoo Jehangir J 
Published: March 2019

Abstract

OBJECTIVES:
Extended-arch techniques offer the potential to comprehensively treat acute type-A aortic dissection (ATAAD), but add surgical complexity compared to the standard hemiarch technique. This study describes both perioperative and mid-term outcomes following the introduction of an extended-arch technique for ATAAD.

METHODS:
Ours is a retrospective single-centre observational study of 95 consecutive patients with ATAAD from 2011 to 2016. The decision to perform extended-arch or hemiarch repair was individualized based on clinical and radiological features. Extended-arch repair was defined as replacement of the ascending aorta and arch with reimplantation of head vessels with or without distal endovascular extension. Clinical follow-up was 100% complete. Cross-sectional double-oblique measurements were performed for aortic remodelling analysis.

RESULTS:
Extended-arch (n = 28) and hemiarch (n = 67) repair resulted in a in-hospital mortality of 10% (n = 3) and 10%, (n = 7), and permanent neurological deficit rate of 7% and 12%, respectively. At a mean imaging follow-up duration of 2.7 ± 1.5 years, false lumen thrombosis was achieved in 57% and 9% of patients undergoing extended-arch and hemiarch repair, respectively. Rate of growth in the proximal descending aorta was 0.7 ± 2.3 mm/year in the extended-arch group vs 2.7 ± 3.9 mm/year in the hemiarch group. At a mean clinical follow-up time of 3.0 ± 1.6 years, open surgical aortic reoperation was 0% in the extended-arch group and 22% in the hemiarch group.

CONCLUSIONS:
Extended-arch repair of ATAAD can be introduced in the acute setting without increase in perioperative mortality or morbidity. At mid-term follow-up, extended-arch for ATAAD improves aortic remodelling and reduces the need for open surgical reoperation.
First report of a hybrid robotic beating-heart quadruple totally endoscopic coronary artery bypass: toward complete revascularization
Authors: Kitahara Hiroto , Hirai Taishi , Nathan Sandeep , Balkhy Husam H 
Published: March 2019

Abstract
To the best of our knowledge, this is the first report describing robotic beating-heart quadruple all-arterial totally endoscopic coronary artery bypass combined with percutaneous coronary intervention attempting complete revascularization (residual SYNTAX score 0). A 66-year-old male with severe triple-vessel coronary artery disease underwent percutaneous coronary intervention for a sub-total occlusion of the right coronary artery as the initial component of a hybrid revascularization strategy. Subsequently, the left coronary system was revascularized via robotic beating-heart totally endoscopic coronary artery bypass with bilateral internal mammary artery grafts.
Are two internal thoracic grafts better than one? An analysis of 5301 cases
Authors: Pevni Dmitry , Mohr Rephael , Kramer Amir , Paz Yosef , Nesher Nachum , Ben-Gal Yanai 
Published: March 2019

Abstract

OBJECTIVES
Although bilateral internal thoracic artery (BITA) grafting is associated with improved survival, many surgeons are reluctant to use this technique due to its greater complexity and the potentially increased risk of sternal infection. This observational study examined if BITA grafting provides improved outcomes compared with single internal thoracic artery (SITA) grafting in patients with multivessel coronary disease.

METHODS
Patients in our institution who underwent BITA grafting during 1996–2011 were compared to those who underwent SITA grafting during the same period. To adjust for differences in demographic and clinical characteristics, patients were matched by propensity score. The Cox model was used to identify predictors of decreased survival and the Kaplan–Meier analysis was performed, both for the entire cohort and for the matched cohort.

RESULTS
SITA patients were older than BITA patients, included more females, and were more likely to have chronic obstructive lung disease, an ejection fraction <30%, diabetes, renal insufficiency, peripheral vascular disease and emergency and repeat operations. Three-vessel and left main diseases were more common among BITA patients, and operative mortality was reduced (2.1% vs 3.6% for SITA, P = 0.002). Sternal infection and stroke rates were similar for the groups. Ten-year Kaplan–Meier survival of BITA patients was better (71.2% vs 56.8%, respectively, P < 0.001). BITA grafting was found to be a predictor of better survival in the analysis of the matched cohort (P < 0.001).

CONCLUSIONS
Our results support the routine use of BITA grafting in patients who undergo myocardial revascularization.
Klotho: An Elephant in Aging Research
Authors: Cheikhi Amin , Barchowsky Aaron , Sahu Amrita , Shinde Sunita N , Pius Abish , Clemens Zachary J , Li Hua , Kennedy Charles A , Hoeck Joerg D , Franti Michael , Ambrosio Fabrisia 
Published: March 2019

Abstract
The year 2017 marked the 20th anniversary of the first publication describing Klotho. This single protein was and is remarkable in that its absence in mice conferred an accelerated aging, or progeroid, phenotype with a dramatically shortened life span. On the other hand, genetic overexpression extended both health span and life span by an impressive 30%. Not only has Klotho deficiency been linked to a number of debilitating age-related illnesses but many subsequent reports have lent credence to the idea that Klotho can compress the period of morbidity and extend the life span of both model organisms and humans. This suggests that Klotho functions as an integrator of organ systems, making it both a promising tool for advancing our understanding of the biology of aging and an intriguing target for interventional studies. In this review, we highlight advances in our understanding of Klotho as well as key challenges that have somewhat limited our view, and thus translational potential, of this potent protein.
Short-Term Increases in Aphid Dispersal From Defensive Dropping Do Not Necessarily Affect Long-Term Biological Control by Parasitoids
Authors: La-Spina Michelangelo , Jandricic Sarah E , Buitenhuis Rose 
Published: March 2019

AbstractFoxglove aphid (Aulacorthum solani (Kaltenbach) (Hemiptera: Aphididae)) is one of the principal aphid pests of greenhouse ornamental crops in North America. Biological control of foxglove aphid mostly relies on the use of Aphidius ervi Haliday (Hymenoptera: Braconidae). However, studies indicate that A. ervi may not be adapted to search for A. solani, and that in response to parasitoid attack aphids can drop and/or disperse, which may aggravate an infestation. Our goal was to further describe the searching behavior of A. ervi in the presence of foxglove aphids, the corresponding defensive behavior of foxglove aphid and the short- and medium-term effects on both pest dispersal and control by A. ervi. Behavioral observations were done on top and bottom leaves infested with foxglove aphid and a high release rate of A. ervi. Parasitoids tended to land on top leaves; however, more aphids were parasitized on bottom leaves, leading to equal numbers of parasitoid attacks in both locations. Most aphids dropped off the plant in the presence of a parasitoid. In large cage experiments, aphids were allowed to distribute naturally and A. ervi was released. The parasitoid still caused a high rate of aphid dropping. However, only a few aphids were able to successfully reach new plants, and most of these mummified over time. Our studies confirm that parasitoid-induced dispersal of foxglove aphid in greenhouse crops does occur, but also suggests this should not necessarily be a barrier to adoption of biological control, as A. ervi controls the aphids over time.
Searching for the 380 GHz H2O emission from the high-z lensed quasi-stellar object MG J0414+0534
Authors: Kuo Cheng-Yu , Suyu Sherry H , Impellizzeri Violette , Braatz James A 
Published: March 2019

Abstract
We report the results of our search for the 380 GHz H2O line emissions from the quadruply lensed quasi-stellar object (QSO) MG J0104+0534 at z = 2.639 with the Atacama Large Millimeter/submillimeter Array. Our observation shows a tentative detection of the 380 GHz line from the lensed QSO, and the line spectrum shows a broad spectral distribution that has a velocity width of ∼290 km s−1 and a peak flux of ∼0.8 mJy. The integrated intensity map of the H2O line shows lensed emissions at the A1 and A2 component of the QSO, with the A2 component slightly resolved. The integrated line flux ratio between the A1 and A2 components shows an unexpected difference from the continuum flux ratio. Based on our gravitational lens modeling, assuming our tentative detection is real, this flux ratio anomaly would suggest that the 380 GHz line emissions come from two or three spatially displaced locations in the QSO, with the dominant one located at the position of the continuum emission from the QSO, and the other one(s) displaced from the continuum by ∼1.5 kpc on the source plane.
Factors Influencing Neonatal Practice in a Rural Community in Kano (Northern), Nigeria
Authors: Farouk Zubaida Ladan , Slusher Tina M , Danzomo Abba Ahmed , Slusher Ida L 
Published: March 2019

Abstract
Nigeria has the highest number of neonatal and under-five deaths in Africa. Socio-cultural determinants play an important role in disease burden in low-middle income countries.
This study aimed to describe knowledge, attitudes and neonatal care practice among household caregivers in a rural community in Nigeria, specifically uvulectomy, female genital mutilation (FGM), failure to routinely immunize and unsafe cord care. Further, relationships between demographic characteristics and knowledge, attitudes and neonatal care practices among caregivers were analyzed.
The study design was descriptive correlational and cross-sectional. Consented caregivers (N = 298) were enrolled and interviewed using a structured questionnaire.
Data were collected on demographic characteristics of the study participants and practice of uvulectomy, FGM, immunization and cord care.
Statistically significant correlations were found between the practice of uvulectomy, FGM and failure to immunize based on occupation (p = 0.0202, p = 0.0290, p = 0.0071) and educational level (p =< 0.0001, p =< 0.0001, p =< 0.0001), with variations by ethnicity.
Intense, preventative health measures and maternal education to eliminate harmful care practices are essential to influence outcomes.
Augmented and Virtual Reality Instrument Tracking for Minimally Invasive Spine Surgery
Authors: Burström Gustav , Nachabe Rami , Persson Oscar , Edström Erik , Elmi Terander Adrian 
Published: March 2019

Study Design.
Cadaveric animal laboratory study.

Objective.
To evaluate the feasibility and accuracy of pedicle cannulation using an augmented reality surgical navigation (ARSN) system with automatic instrument tracking, yielding feedback of instrument position in relation to deep anatomy.

Summary of Background Data.
Minimally invasive spine surgery (MISS) has the possibility of reducing surgical exposure resulting in shorter hospital stays, lower blood loss and infection rates compared with open surgery but the drawback of limiting visual feedback to the surgeon regarding deep anatomy. MISS is mainly performed using image-guided 2D fluoroscopy, thus exposing the staff to ionizing radiation.

Methods.
A hybrid operating room (OR) equipped with a robotic C-arm with integrated optical cameras for augmented reality instrument navigation was used. In two pig cadavers, cone beam computed tomography (CBCT) scans were performed, a 3D model generated, and pedicle screw insertions were planned. Seventy-eight insertions were performed. Technical accuracy was assessed on post-insertion CBCTs by measuring the distance between the navigated device and the corresponding pre-planned path as well as the angular deviations. Drilling and hammering into the pedicle were also compared. Navigation time was measured. An independent reviewer assessed a simulated clinical accuracy according to Gertzbein.

Results.
The technical accuracy was 1.7 ± 1.0 mm at the bone entry point and 2.0 ± 1.3 mm at the device tip. The angular deviation was 1.7 ± 1.7° in the axial and 1.6 ± 1.2° in the sagittal plane. Navigation time per insertion was 195 ± 93 seconds. There was no difference in accuracy between hammering and drilling into the pedicle. The clinical accuracy was 97.4% to 100% depending on the screw size considered for placement. No ionizing radiation was used during navigation.

Conclusion.
ARSN with instrument tracking for MISS is feasible, accurate, and radiation-free during navigation.

Level of Evidence: 3