bluuebunny/crossref_metadata_2025_split huggingface dataset:
Granzyme B Produced by Natural Killer Cells Enhances Inflammatory Response and Contributes to the Immunopathology of Cutaneous Leishmaniasis
Authors: Campos Taís M , Novais Fernanda O , Saldanha Maíra , Costa Rúbia , Lordelo Morgana , Celestino Daniela , Sampaio Camilla , Tavares Natália , Arruda Sérgio , Machado Paulo , Brodskyn Cláudia , Scott Phillip , Carvalho Edgar M , Carvalho Lucas P 
Published: October 2019

AbstractBackgroundSkin lesions from patients infected with Leishmania braziliensis has been associated with inflammation induced by cytotoxic CD8+ T cells. In addition, CD8+ T cell-mediated cytotoxicity has not been linked to parasite killing. Meanwhile, the cytotoxic role played by natural killer (NK) cells in cutaneous leishmaniasis (CL) remains poorly understood.MethodsIn this study, we observed higher frequencies of NK cells in the peripheral blood of CL patients compared with healthy subjects, and that NK cells expressed more interferon-γ, tumor necrosis factor (TNF), granzyme B, and perforin than CD8+ T cells.ResultsWe also found that most of the cytotoxic activity in CL lesions was triggered by NK cells, and that the high levels of granzyme B produced in CL lesions was associated with larger lesion size. Furthermore, an in vitro blockade of granzyme B was observed to decrease TNF production.ConcclusionsOur data, taken together, suggest an important role by NK cells in inducing inflammation in CL, thereby contributing to disease immunopathology.
Indirect Accountability for Extraterritorial Human Rights Violations
Authors: Heupel Monika 
Published: October 2019

Abstract
This article examines how states and international organizations can be held to account for extraterritorial human rights violations. I develop and investigate the potential of what I call an “indirect accountability” mechanism. In indirect accountability relationships, accountability fora do not directly hold states and international organizations that commit extraterritorial human rights violations to account as these are frequently immune to direct accountability claims. Instead, they hold them to account indirectly by addressing accountability claims to an implicated third party, expecting that the third party will upload the accountability claims to the state or international organization. After conceptualizing the mechanism and its scope conditions, I conduct two brief qualitative case studies using the method of deductive process tracing to explore the potential of the mechanism. The first case study traces efforts to indirectly hold the United States to account for violating foreigners’ privacy rights in the context of mass surveillance. The second case study traces attempts to indirectly hold the United Nations Security Council to account for violating the due process rights of blacklisted terror suspects. Both case studies provide support for the mechanism.
Hand Gesture-Based Virtual Reality Training Simulator for Collaboration Rescue of a Railway Accident
Authors: Xu Jianxi , Tang Zhao , Zhao Huiwen , Zhang Jianjun 
Published: October 2019

Abstract
Training simulator is an efficient and innovative tool to help users learn professional skills due to its convenience and safety. However, complex human–computer interaction is one of the main disadvantages that limit its effectiveness in safety training, especially for the rescue of a railway accident that requires collaborations. Through designing a set of task-specific hand gestures, we developed a training simulator for the recovery of a railway accident that helps the rescuers learn and practice rescue skills in a life-like environment and gain the firsthand experience. To test the validity of our training simulator, a user experiment is designed to compare it with the controller-based simulator in a between-groups study with 51 participants, focusing on different aspects of effectiveness. The results demonstrate that the hand gesture-based controller can be more efficient and usable to deal with complex interactions than the traditional hand-held controller.
Identification of a mecA/mecC-positive MRSA ST1-t127 isolate from a racehorse in Japan
Authors: Sekizuka Tsuyoshi , Niwa Hidekazu , Kinoshita Yuta , Uchida-Fujii Eri , Inamine Yuba , Hashino Masanori , Kuroda Makoto 
Published: October 2019

Abstract

Objectives
MRSA is a known pathogen that affects horses. We investigated an equine MRSA isolate for potential antimicrobial resistance genes, classified the staphylococcal cassette chromosome mec (SCCmec) and identified the strain-specific dissemination in the horse community based on WGS.

Methods
WGS, using short-read sequencing, and subsequent long-read sequencing by hybrid assembly, was conducted to obtain a complete genome sequence. Pairwise sequence alignment of relative SCCmec sequences and core-genome phylogenetic analysis were performed to highlight transmission routes of the SCCmec and MRSA strain-specific lineages.

Results
In 2018, we isolated the MRSA JRA307 strain from the pus of a wound on a racehorse and the complete genome sequence suggests that it is a clinically relevant pvl-negative ST1-t127 MRSA that harbours both mecA and mecC on SCCmec-307. SCCmec-307 exhibited marked sequence identity to the previously reported SCCmec–mecC in the Staphylococcus sciuri GVGS2 strain isolated from cattle. The JRA307 mecC gene was classified as a mecC allotype of S. sciuri rather than that of Staphylococcus aureus.

Conclusions
We demonstrated the complete genome sequence of equine isolate JRA307, which is a clinically relevant MRSA harbouring mecA and mecC on SCCmec-307. The finding of mecC MRSA suggests a possible SCCmec transmission between distinct staphylococcal species. To the best of our knowledge, this is the first report of mecC detection in Japan.
Biphasic moult cycle of the parasitic isopod Norileca indica (H. Milne Edwards, 1840) (Isopoda: Cymothoidea): stage-wise characterisation and haemolymph ecdysteroids titre
Authors: Sahadevan Amrutha Vani , Jose Priya T A , Kappalli Sudha 
Published: October 2019

AbstractNorileca indica (H. Milne Edwards, 1840) is a protandrous hermaphroditic and obligatory parasitic isopod of scombrid fishes. The posterior and anterior biphasic moult cycles in the adult phases (male, transitional, and female) of this species are characterised based on the microscopic changes reflected in the uropod exopodite and maxillule, respectively. Biphasic parturial moult as well as the moult removing the old brood pouch characteristic of ovigerous females was recorded. Assay of haemolymph ecdysteroids titre with respect to different biphasic moult cycle stages appears to be first report of its kind among aquatic and/or parasitic isopods. The ecdysteroids titre showed significant fluctuation in relation to the moult cycle stages, while the parasite was at a biphasically intermoult stage, titre was estimated to be 13.64 ± 2.09 ng ml–1. By the onset of the premoult at the posterior body region, titre showed a gradual increase and reached a maximum level (328.54 ± 70.17 ng ml–1; P = 0.0060) when the parasite was at late premoult at the posterior body part and mid premoult stage at the anterior body part. There was a subsequent sharp decline (92.8 ± 12.95 ng ml–1; P = 0.002) soon after the ecdysis of the posterior part by the time premoult changes in the anterior part advanced as late premoult and about to moult. The level of ecdysteroids titre was 55.56 ± 14.47 ng ml–1 when the parasite completed anterior ecdysis and reached postmoult. Data on the monthly occurrence of biphasic moult cycles revealed that a mean average of 23.26% of the adult population undergoes premoult/ecdysis/postmoult activities throughout the year. The rate of moulting showed a decline (16.12 ± 0.60%) during the monsoon months (June-August) when compared to pre-summer/summer (February-May) (24.83 ± 2.42%) and post-monsoon/winter (September-January) (26.28 ± 1.75; P = 0.005).
Efficacy of Active Ingredients From the EPA 25(B) List in Reducing Attraction of Aedes aegypti (Diptera: Culicidae) to Humans
Authors: Mitra Soumi , Rodriguez Stacy D , Vulcan Julia , Cordova Joel , Chung Hae-Na , Moore Emily , Kandel Yashoda , Hansen Immo A 
Published: October 2019

AbstractMosquitoes of the Aedes genus are vectors for dengue, chikungunya, Zika, and yellow fever viruses. Mosquito repellents are an effective way to prevent mosquito bites and reduce the spread of mosquito-borne diseases. In the early 90s, the U.S. Environmental Protection Agency (EPA) published a list of active ingredients that pose minimum risk to human health that can be used as pesticides or repellents without passing the EPA registration process. The present study examined the efficacy of 21 of the active ingredients listed by the EPA 25 (B) exempt list and five commercially available sprays that only contained active ingredients from the EPA 25(B) list in repelling female Aedes aegypti (L.) females. We performed choice bioassays in a controlled laboratory environment, using a Y-tube olfactometer to determine attraction rates of humans to female Ae. aegypti in the presence of one of the 21 active ingredients and five commercially available repellent sprays. We found that cinnamon oil, peppermint oil, spearmint oil, lemongrass oil, and garlic oil reduced mosquito attraction to human odor. Of the five commercial repellent sprays, only one reduced mosquito attraction for up to 30 min in our assay. The EPA 25 (B) list contains active ingredients that under the conditions of our assay repel Ae. aegypti.
The effect of the metallicity-specific star formation history on double compact object mergers
Authors: Neijssel Coenraad J , Vigna-Gómez Alejandro , Stevenson Simon , Barrett Jim W , Gaebel Sebastian M , Broekgaarden Floor S , de Mink Selma E , Szécsi Dorottya , Vinciguerra Serena , Mandel Ilya 
Published: October 2019

ABSTRACT
We investigate the impact of uncertainty in the metallicity-specific star formation rate over cosmic time on predictions of the rates and masses of double compact object mergers observable through gravitational waves. We find that this uncertainty can change the predicted detectable merger rate by more than an order of magnitude, comparable to contributions from uncertain physical assumptions regarding binary evolution, such as mass transfer efficiency or supernova kicks. We statistically compare the results produced by the COMPAS population synthesis suite against a catalogue of gravitational-wave detections from the first two Advanced LIGO and Virgo observing runs. We find that the rate and chirp mass of observed binary black hole mergers can be well matched under our default evolutionary model with a star formation metallicity spread of 0.39 dex around a mean metallicity 〈Z〉 that scales with redshift z as 〈Z〉 = 0.035 × 10−0.23z, assuming a star formation rate of $0.01 \times (1+z)^{2.77} / (1+((1+z)/2.9)^{4.7}) \, \rm {M}_\odot$ Mpc−3 yr−1. Intriguingly, this default model predicts that 80 per cent of the approximately one binary black hole merger per day that will be detectable at design sensitivity will have formed through isolated binary evolution with only dynamically stable mass transfer, i.e. without experiencing a common-envelope event.
Be it therefore resolved: cosmological simulations of dwarf galaxies with 30 solar mass resolution
Authors: Wheeler Coral , Hopkins Philip F , Pace Andrew B , Garrison-Kimmel Shea , Boylan-Kolchin Michael , Wetzel Andrew , Bullock James S , Kereš Dušan , Faucher-Giguère Claude-André , Quataert Eliot 
Published: October 2019

ABSTRACT
We study a suite of extremely high-resolution cosmological Feedback in Realistic Environments simulations of dwarf galaxies ($M_{\rm halo} \lesssim 10^{10}\rm \, M_{\odot }$), run to z = 0 with $30\, \mathrm{M}_{\odot }$ resolution, sufficient (for the first time) to resolve the internal structure of individual supernovae remnants within the cooling radius. Every halo with $M_{\rm halo} \gtrsim 10^{8.6}\, \mathrm{M}_{\odot }$ is populated by a resolved stellar galaxy, suggesting very low-mass dwarfs may be ubiquitous in the field. Our ultra-faint dwarfs (UFDs; $M_{\ast }\lt 10^{5}\, \mathrm{M}_{\odot }$) have their star formation (SF) truncated early (z ≳ 2), likely by reionization, while classical dwarfs ($M_{\ast }\gt 10^{5}\, \mathrm{M}_{\odot }$) continue forming stars to z &lt; 0.5. The systems have bursty star formation histories, forming most of their stars in periods of elevated SF strongly clustered in both space and time. This allows our dwarf with M*/Mhalo &gt; 10−4 to form a dark matter core ${\gt}200\rm \, pc$, while lower mass UFDs exhibit cusps down to ${\lesssim}100\rm \, pc$, as expected from energetic arguments. Our dwarfs with $M_{\ast }\gt 10^{4}\, \mathrm{M}_{\odot }$ have half-mass radii (R1/2) in agreement with Local Group (LG) dwarfs (dynamical mass versus R1/2 and stellar rotation also resemble observations). The lowest mass UFDs are below surface brightness limits of current surveys but are potentially visible in next-generation surveys (e.g. LSST). The stellar metallicities are lower than in LG dwarfs; this may reflect pre-enrichment of the LG by the massive hosts or Pop-III stars. Consistency with lower resolution studies implies that our simulations are numerically robust (for a given physical model).
Discovery of an edge-on galaxy with X-shaped bi-cone – SDSS J171359.00+333625.5
Authors: Bao Min , Chen Yan-mei , Yuan Qi-rong , Shi Yong , Bizyaev Dmitry , Yu Xiao-ling , Gu Qiu-sheng , Yu Ying 
Published: October 2019

ABSTRACT
Using the integral field unit (IFU) data from Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, we study the kinematics of gas and stellar components in an edge-on Seyfert 2 galaxy, SDSS J171359.00+333625.5, with X-shaped bi-conical outflows. The gas and stars therein are found to be counter-rotating, indicating that the collision between the inner and external gas might be an effective way to dissipate the angular momentum, which leads to remarkable gas accretion into the galaxy centre. Large [O iii]λ5007 equivalent width and AGN-like line ratio in the large bi-conical region suggest that the gas is ionized by the central AGN. The gas velocity in the bi-cone region shows that ionized gas is receding relative to the galaxy centre, which could be the joint effect of inflows, outflows, and disc rotation. We are probably witnessing the case where a great amount of gas in the disc is being efficiently accreted into the central black hole, and the AGN-driven galactic winds are blown out along the bi-cone. The kinematics of oxygen, including rotation velocity and velocity dispersion, is different from other elements, like hydrogen, nitrogen, and sulphur. The rotation velocity estimated from oxygen is slower than from other elements. The velocity dispersion of other elements follows galactic gravitational potential, while the velocity dispersion of oxygen stays roughly constant along the galactic major-axis. The further advanced observations, e.g. of cold gas or with an IFU of higher spatial resolution, are required to better understand this object.
Estimating covariance matrices for two- and three-point correlation function moments in Arbitrary Survey Geometries
Authors: Philcox Oliver H E , Eisenstein Daniel J 
Published: October 2019

ABSTRACT
We present configuration-space estimators for the auto- and cross-covariance of two- and three-point correlation functions (2PCF and 3PCF) in general survey geometries. These are derived in the Gaussian limit (setting higher order correlation functions to zero), but for arbitrary non-linear 2PCFs (which may be estimated from the survey itself), with a shot-noise rescaling parameter included to capture non-Gaussianity. We generalize previous approaches to include Legendre moments via a geometry-correction function calibrated from measured pair and triple counts. Making use of importance sampling and random particle catalogues, we can estimate model covariances in fractions of the time required to do so with mocks, obtaining estimates with negligible sampling noise in ∼10 (∼100) CPU-hours for the 2PCF (3PCF) autocovariance. We compare results to sample covariances from a suite of BOSS DR12 mocks and find the matrices to be in good agreement, assuming a shot-noise rescaling parameter of 1.03 (1.20) for the 2PCF (3PCF). To obtain strongest constraints on cosmological parameters, we must use multiple statistics in concert; having robust methods to measure their covariances at low computational cost is thus of great relevance to upcoming surveys.
The mass–metallicity and the fundamental metallicity relation revisited on a fully Te-based abundance scale for galaxies
Authors: Curti Mirko , Mannucci Filippo , Cresci Giovanni , Maiolino Roberto 
Published: October 2019

ABSTRACT
The relationships between stellar mass, gas-phase metallicity and star-formation rate (i.e. the mass–metallicity, MZR, and the fundamental metallicity relation, FMR) in the local Universe are revisited by fully anchoring the metallicity determination for SDSS galaxies on the Te abundance scale defined exploiting the strong-line metallicity calibrations presented by Curti et al. Self-consistent metallicity measurements allow a more unbiased assessment of the scaling relations involving M, Z and SFR, which provide powerful constraints for the chemical evolution models. We parametrize the MZR with a new functional form that allows us to better characterize the turnover mass. The slope and saturation metallicity are in good agreement with previous determinations of the MZR based on the Te method, while showing significantly lower normalization compared to those based on photoionization models. The Z–SFR dependence at fixed stellar mass is also investigated, being particularly evident for highly star-forming galaxies, where the scatter in metallicity is reduced up to a factor of ${\sim}30{{\ \rm per\ cent}}$. A new parametrization of the FMR is given by explicitly introducing the SFR dependence of the turnover mass into the MZR. The residual scatter in metallicity for the global galaxy population around the new FMR is 0.054 dex. The new FMR presented in this work represents a useful local benchmark to compare theoretical predictions and observational studies (of both local and high-redshift galaxies) whose metallicity measurements are tied to the abundance scale defined by the Te method, hence allowing proper assessment of its evolution with cosmic time.
miR-181a-2* expression is different amongst carcinomas from the colorectal serrated route
Authors: Kondelova Alexandra , Alburquerque-González Begoña , Vychytilova-Faltejskova Petra , García-Solano José , Prochazka Vladimir , Kala Zdenek , Pérez Fernando , Slaby Ondrej , Conesa-Zamora Pablo 
Published: October 2019

Abstract
Serrated adenocarcinoma (SAC) and colorectal carcinomas showing histological and molecular features of high-level of microsatellite instability (hmMSI-H) are both end points of the serrated pathway of colorectal carcinogenesis. Despite common features (right-sided location, CpG island methylation phenotype and BRAF mutation) there are no studies comparing the microRNA (miRNA) expression profiles in SACs and hmMSI-H. The microtranscriptome from 12 SACs and 8 hmMSI-H were analysed using Affymetrix GeneChip miRNA 3.0 arrays and differentially enriched functions involving immune response were observed from this comparison. miR-181a-2* was found significantly more expressed in hmMSI-H than in SAC and higher expression of this miRNA in microsatellite unstable colorectal cancer were corroborated by Real-Time PCR in an extended series (61 SAC, 21 hmMSI-H). An analysis of genes possibly regulated by miR-181a-2* was carried out and, amongst these, an inverse correlation of NAMPT with miR-181a-2* expression was observed, whereas, for TRAF1 and SALL1, additional regulation mechanisms involving CpG island methylation were observed. miR-181a-2* is associated with particular histological and molecular features of colorectal carcinomas within the serrated pathological pathway and might play a role in the immune responses of microsatellite instability carcinomas.
Vertebral Artery to Common Carotid Artery Transposition: 2-Dimensional Operative Video
Authors: Hendricks Benjamin K , Spetzler Robert F 
Published: October 2019

Abstract
Vertebral artery (V1 segment) transposition is a useful technique in the treatment of patients with either proximal subclavian artery stenosis with vertebral “steal” syndrome or severe vertebral artery origin stenosis. This patient required extracranial augmentation of right vertebral artery blood flow to treat proximal vertebral artery stenosis. This was achieved through a V1 to common carotid artery end-to-side anastomosis. The end-to-side anastomosis was performed with the first stitch after the heel stich placed to the inside of the vessel, and the back wall was run from the inside. The anastomosis was completed by running along the front wall from the external surface of the arteries. The anastomosis was flushed by temporary removal of the proximal carotid artery clamp. The anastomotic suture was then tied, and clamps were removed. The patient gave informed consent for surgery and video recording. Institutional review board approval was deemed unnecessary. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.
Banks’ Risk Dynamics and Distance to Default
Authors: Nagel Stefan , Purnanandam Amiyatosh 
Published: October 2019

Abstract
We adapt structural models of default risk to take into account the special nature of bank assets. The usual assumption of lognormally distributed asset values is not appropriate for banks. Typical bank assets are risky debt claims with concave payoffs. Because of the payoff nonlinearity, bank asset volatility rises following negative shocks to borrower asset values. As a result, standard structural models with constant asset volatility can severely understate banks’ default risk in good times when asset values are high. Additionally, bank equity return volatility is much more sensitive to negative shocks to asset values than in standard structural models.
Rumen CO2 species equilibrium might influence performance and be a factor in the pathogenesis of subacute ruminal acidosis
Authors: Laporte-Uribe José A 
Published: October 2019

AbstractThis experiment was conducted to explore rumen carbon dioxide (CO2) species equilibrium. Three lactating, fistulated cattle were consecutively exposed to three dietary treatments tailored to produce low rumen pH and increase the risk of subacute ruminal acidosis (SARA) by reducing physically effective neutral detergent fiber (Low peNDF), increasing rumen degradable starch (High RDS) or both (Combined). Under these conditions, high and varied rumen concentrations of the CO2 associated to water or dissolved CO2 (dCO2) were found. The results suggest that the activity of dCO2 and bicarbonate (HCO3−) represents an important component of the rumen environment. Rumen CO2 holdup was associated with high dCO2 and HCO3− activity as well as changes in the viscosity and surface tension of the rumen fluid. All dietary treatments produced low rumen pH, &lt;5.5 for &gt;3 h/d, a condition associated with SARA, but clinical SARA was observed only during CO2 holdup. This pilot study highlights the possible role of CO2 holdup and rumen CO2 species in cattle performance and nutritional diseases. In the future, better estimations of CO2 species might help clarify these findings.