bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actividad Hipolipemiante de la flor de ayote (Cucurbita moshata)
Authors: Córdova Diana , Soto Claudia , Valle Floridalva , Mejía José Guillermo 
Published: June 2019

Resumen
Introducción: Las flores de Cucurbita moschata son utilizadas generalmente para el consumo en ciertos lugares de Latinoamérica. En su totalidad cuenta con amplios usos terapéuticos; por ello se han realizado algunos esfuerzos para validar estos resultados en condiciones controladas. Objetivo: Evaluar la toxicidad y la actividad hipolipemiante de la decocción de la flor de C. moschata en ratones experimentales. Metodología: La sustancia de estudio se administró diariamente por vía oral durante cuatro semanas en tres concentraciones; 1 g/10 mL, 3 g/10 mL y 6g /10 mL, además se utilizó un grupo control. Dos semanas antes se indujeron a una dieta alta en grasa y carbohidratos que se mantuvo durante toda la investigación. Previamente se evaluó la toxicidad oral de 28 días de la concentración más alta. Resultados: La concentración evaluada, no presentó toxicidad en los animales tratados. En la actividad hipolipemiante se mostró una disminución en los niveles de glucosa para todos los tratamientos, mientras que en triglicéridos y colesterol solamente disminuyeron los niveles las concentraciones baja y media. Conclusiones: La decocción evaluada tiene potencial para el tratamiento de las dislipidemias sin producir efectos adversos en ratones de laboratorio.
Análisis de la violencia en las mujeres con un modelo de escenarios de riesgo
Authors: Morán Jonathan 
Published: June 2019

Introducción. En El Salvador, la probabilidad de encontrar una mujer víctima de violencia basada en género es de 34 mujeres por cada 100. Objetivo. Construir escenarios de riesgo, y riesgo relativo en la mujer, partiendo de características como los antecedentes de violencia en la niñez y aspectos sociodemográficos que incrementan la probabilidad de que se convierta en víctima de algún tipo de violencia. Metodología. Análisis de los factores que incrementan el riesgo que una mujer sea víctima de algún tipo de violencia mediante un modelo de probabilidades de respuesta cualitativa usando la base de datos de la Encuesta Nacional de Violencia contra las Mujeres 2017. Resultados. En promedio, la probabilidad de que una mujer se convierta en víctima de algún tipo de violencia es del 29.3 por ciento, considerando los valores medios de la densidad poblacional, la edad y el antecedente personal de la mujer. Conclusiones. El antecedente personal de la mujer es determinante ya que el riesgo relativo aumenta si la mujer fue víctima de violencia antes de los 15 años, en ese caso, las posibilidades se triplican respecto al grupo de mujeres sin historial de violencia.
Captains and Priestesses in Afro-Brazilian Congado and Candomblé
Authors: Dempsey Genevieve E. V. 
Published: June 2019

Abstract
Afro-Brazilian communities that practice the religious traditions of Congado and Candomblé consider not only the significance of the sacred in their lives but also the importance of female enfranchisement. This article explores how practitioners, known as Congadeiros/as and Candomblecistas, have increasingly shaped and reshaped the roles of men and women in ritual music to reflect a growing consciousness of gender equality. In the broadest sense, this article plumbs the gendered conditions of possibility in Congado and Candomblé to help us more fully comprehend how the multivalent voices of the self and the community emerge from within these strongholds of sacred conviction. This article is valuable because it brings together the social, political, and cultural at the locus of the sonic and the somatic. Furthermore, by exploring how women and men harness music and dance in ritual contexts, it makes legible how modern Congadeiros/as and Candomblecistas strive for goals such as equitable treatment and sensitizes the wider public to the dignity and dimensionality of marginalized communities. As practitioners of Candomblé and Congado continue to illuminate their musical cultures of gender equality, they succeed in amplifying both their visible identities and their voices.
Resumo. As comunidades Afro-Brasileiras que praticam as tradições religiosas do Congado e do Candomblé não consideram apenas o significado do sagrado em suas vidas, mas também a importância da emancipação feminina. Este artigo explora como praticantes, conhecidos como Congadeiros/as e Candomblecistas, těm moldado e remodelado cada vez mais os papéis de homens e mulheres na música ritual para refletir uma consciěncia crescente da igualdade de gěnero. No sentido mais amplo, este artigo examina as condições de possibilidade de gěnero no Congado e no Candomblé para nos ajudar a compreender melhor como as vozes multivalentes do indivíduo e da comunidade emergem dessas bastiões da convicção sagrada. Este artigo é valioso porque reúne aspectos sociais, políticos e culturais no lugar dos sonoros e somáticos. Além disso, ao explorar como as mulheres e os homens aproveitam a música e a dança em contextos rituais, reflete sobre como os modernos Congadeiros/ as e Candomblecistas lutam pelo tratamento equitativo e sensibiliza o público em geral para a dignidade e a dimensão dessas comunidades marginalizadas. Na medida em que os praticantes do Candomblé e do Congado continuam a iluminar a igualdade de gěnero em suas culturas musicais, conseguem ampliar suas identidades visíveis e suas vozes.
The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma
Authors: Li Kun , Zhang Chengcheng , Chen Lei , Wang Pingping , Fang Yang , Zhu Junwei , Chen Shuo , Du Juan , Shen Bing , Wu Kaile , Liu Yehai 
Published: June 2019

Background
Acetyl-CoA carboxylase (ACC) plays an important role in the metabolism of various cancer cells, but its role in head and neck squamous cell carcinoma (HNSCC) is uncertain. Therefore, in the present study, we explored the role of ACC2 in HNSCC.

Methods
Western blot and immunohistochemistry assays were used to determine ACC2 protein expression levels in laryngocarcinoma and adjacent normal tissues derived from patients with laryngocarcinoma. ACC2 expression was knocked down in the hypopharyngeal cancer cell line FaDu to determine its effect on apoptosis. Lipid oil red staining was used to test the change of intracellular lipid.

Results
The results showed that the ACC2 protein was highly expressed in laryngocarcinoma and that the ACC2 expression level was positively associated with the clinical cancer stage and negatively associated with the degree of laryngocarcinoma cell differentiation. Kaplan–Meier analyses indicated that compared with patients having low levels of ACC2, those with high ACC2 levels had a decreased 5-year survival rate. The results of western blot and terminal deoxynucleotidyl transferase dUTP nick-end labeling assays showed that knockdown of ACC2 accelerated apoptosis in FaDu cells. Furthermore, knockdown of ACC2 significantly reduced the intracellular lipid levels in FaDu cells.

Conclusion
These findings suggest that ACC2 may be an important prognostic marker for patients with HNSCC and that ACC2 may be a potential target in the treatment of HNSCC.
PGM5: a novel diagnostic and prognostic biomarker for liver cancer
Authors: Jiao Yan , Li Yanqing , Jiang Peiqiang , Han Wei , Liu Yahui 
Published: June 2019

BackgroundLiver cancer is a common malignancy and a significant public health problem worldwide, but diagnosis and prognostic evaluation remain challenging for clinicians. Metabolic reprogramming is a hallmark of cancer, and we therefore examined the diagnostic and prognostic value of a metabolic enzyme, phosphoglucomutase-like protein 5 (PGM5), in liver cancer.MethodsAll data were from The Cancer Genome Atlas database. R and related statistical packages were used for data analysis. HepaticPGM5expression was determined in different groups, and the chi-squared test and Fisher’s exact test were used to determine the significance of differences. The pROC package was used to determine receiver operating characteristic (ROC) curves, the survival package was used to for survival analysis and development of a Cox multivariable model, and the ggplot2 package was used for data visualization.ResultsPGM5expression was significantly lower in cancerous than adjacent normal liver tissues, and had modest diagnostic value based on ROC analysis and calculations of area under the curve (AUC). HepaticPGM5expression had positive associations with male sex and survival, but negative associations with advanced histologic type, advanced histologic grade, advanced stage, and advanced T classification. Patents with lowPGM5levels had poorer overall survival and relapse-free survival.PGM5was independently associated with patient prognosis.ConclusionPGM5has potential use as a diagnostic and prognostic biomarker for liver cancer.
Hydroclimatic variations reveal differences in carbon capture in two sympatric conifers in northern Mexico
Authors: González-Cásares Marcos , Pompa-García Marín , Venegas-González Alejandro , Domínguez-Calleros Pedro , Hernández-Díaz José , Carrillo-Parra Artemio , González-Tagle Marco 
Published: June 2019

Background
Forest ecosystems are considered among the largest terrestrial carbon sinks. The dynamics of forest carbon depend on where the carbon is stored and its responses to environmental factors, as well as the physiology of the trees. Thus, threatened forest regions with high biodiversity have great scientific importance, such as the Sierra Madre Occidental in Mexico. A comparative analysis of tree species can expand the knowledge of the carbon cycle dynamics and ecological processes in this region. Here, we examined the growth, wood density, and carbon accumulation of two threatened species (Pseudotsuga menziesii and Cupressus lusitanica) to evaluate their hydroclimatic responsiveness.

Methods
The temporal variations in the carbon accumulation patterns of two co-occurring species (P. menziesii and C. lusitanica) and their sensitivity to the local climate were studied using dendroecological techniques, X-ray densitometry, and allometric equations.

Results
The results show that the annual carbon accumulation in C. lusitanica is positively associated with the temperature during the current fall, while the carbon accumulation in P. menziesii is correlated with the rainfall during the winter of the previous year. The climatic responses are associated with the intra-annual variations of wood density and ring widths for each species. The ring width was strongly correlated with carbon accumulation in C. lusitanica, while the mean wood density was linked to carbon accumulation in P. menziesii.

Discussion
This study has implications for the carbon accumulation rates of both species, revealing differences in the carbon capture patterns in response to climatic variations. Although the species coexist, there are variation in the hydroclimatic sensitivity of the annual carbon sequestered by trunks of trees, which would be associated with tree-ring width and/or wood density, i.e., directly by anatomical features. The results are relevant to analyze the response to the variability of climatic conditions expected in the near future of the tree communities of Sierra Madre Occidental. Therefore, this study provides a basis for modeling the long-term carbon budget projections in terrestrial ecosystems in northern Mexico.
Assessment of Level of Susceptibility of Anopheles gambiae S.L to Public Health Insecticides in a Malaria Vector Sentinel Site, Rivers State, Nigeria
Authors: Ebere N. , Atting I. , Ekerette I. , Nioking A. 
Published: June 2019

Aims: To investigate the status of susceptibility of Anopheles gambiae sensu lato (Diptera: Culicidae) mosquitoes to the WHO-approved insecticides for indoor residual spraying in field collected samples in a malaria vector sentinel site in Nigeria and Ts to provide an update on the current status of resistance to the major insecticide classes in wild populations of Anopheles gambiae sensu lato
Study Design: Field and laboratory –experimental design was used in this study.
Place and Duration of the Study: The study was carried out at a malaria surveillance site, established by the National Malaria Elimination Programme at Oduoha-Emohua in Rivers State, between April to September, 2015.
Methodology: Anopheles larvae were collected from stagnant pools around the malaria surveillance site. The mosquitoes were reared to adulthood in the insectary and identified using morphological keys. Two- to three-day old adult female mosquitoes were exposed to standard diagnostic doses of Deltamethrin, Lambdacyhalothrin, Alphacympermethrin, Permethrin, Bendiocarb, Propoxur, DDT and Premiphos-Methyl using standard WHO protocols, insecticide susceptibility test kits and treated papers. Knockdown every 10 min and mortality 24 h post exposure was noted. All Anopheles mosquitoes tested belonged to the Anopheles gambiae-complex.
Results: Mortality results indicated that the vectors were susceptible to Bendiocarb and Alphacympermethrin with mortality rates of 100% and 98% respectively. There was complete resistance to Deltamethrin, Lambdacyhalothrin, Permethrin, Propoxur, DDT and Premiphos-Methyl with mortality ranges of 25%-65%.
Conclusion: The present study shows the effectiveness of Bendiocarb and Alphacympermethrin in malaria control with indoor residual spraying. It also provides baseline information for monitoring the status of insecticide resistance in Rivers State.
Estimation of genetic parameters and prediction of genotypic values in common beans using mixed models#
Authors: C. de F. Ruas, Paulo M. Ruas, Jessica Delfini, Vania Moda Cirino, , Leandro Simões Azeredo Gonçalves José dos Santos Neto, 
Published: June 2019

In the international scenario of agriculture, Brazil stands out as the main producer and consumer of common bean (Phaseolus vulgaris L.) The increase in the productive potential of the crop is mainly due to breeding programs. The objective of this study was to estimate genetic parameters, predict genotypic values ​​with REML/BLUP (Restricted Maximum Likelihood/Best Linear Unbiased Prediction) and, based on these values,​​ study the variability in common bean cultivars with carioca and black grain. Twenty three agromorphological descriptors were evaluated, among them grain yield. Deviance analysis detected significant differences between the cultivars in both groups. Selective accuracy (Ac) was considered high for most of the traits. Broad-sense heritability ( ) ranged from 0.05 to 0.72, but it was low for the trait yield (YLD). In the carioca grain group, the ​​ values for the traits related to plant morphology were higher than in the black group. Nevertheless, the ​​ values in the black group were higher in relation to the pod and seed traits. The correlations for YLD were moderate but different in the two commercial groups studied. In the black group, variables related to the seed morphology were correlated with grain yield, and in the carioca group, traits related to seed quantity. Based on the groupings, variability among the cultivars was observed. Three distinct clusters were formed for the carioca group and four for the black group. Based on the predicted genetic values, genetic variability and the most adapted and stable cultivars were detected among the cultivars in the studied environments.

#This article has been posted in Preprints with a doi 10.20944/preprints201803.0215.v1 (https://www.preprints.org/manuscript/201803.0215/v1) (Creative Commons CC BY 4.0 license)
*Corresponding author, Email: leandrosag@uel.br
Liquid egg products characterization during storage as a response of novel phyto-additives added in hens diet
Authors: Panaite Tatiana Dumitra , Mădălina Iuga Silvia Mironeasa, , Vlaicu Petru Alexandru 
Published: June 2019

This study aims to assess the effect of novel phyto-additives (bilberry leaves, walnut leaves, sea-buckthorn pomace and a mix of bilberry leaves, walnut leaves and sea-buckthorn pomace) added in hens diet on the liquid egg components (egg albumen, egg yolk and whole liquid egg) during storage. The phyto-additives added to the basic feed remarkably affected almost all the characteristics investigated, colour, pH and rheological behaviour of liquid egg products. The changes of egg yolk and albumen's colour and pH were not uniform. The supplementation of feeding with walnut leaves decreases significantly (p < 0.01) the luminosity of egg yolk, whereas the luminosity of egg albumen increases compared to the control. The pH values were influenced by the type of phyto-additive added in the hens diet, but its variations were only slightly dependent on the storage time of eggs. The rheological properties showed a pseudoplasticity of egg components depending on the hens diet and egg storage time. Ostwald-de Waele model fitted well with the rheological data, offering information on the changes of the apparent viscosity in relation to the diet type and storage time. The results indicated that these novel phyto-additives could be incorporated in hens diet for production of improved eggs quality and walnut leaves having a remarkable effect.
Colloids
Authors: Schramm Laurier L. 
Published: June 2019

AbstractA colloid comprises a collection of small particles, droplets, or bubbles of one phase having at least one dimension between about 1 and 1000 nm and dispersed in a second phase. Either or both phases may be in gas, liquid, solid, or supercritical phase states. Another property that distinguishes colloidal dispersions is the extremely large area of the interface between the two phases compared with the mass of the dispersed phase. A consequence is that any chemical and physical phenomena that depend on the existence of an interface become very prominent in colloidal dispersions. Colloidal systems are important because they feature prominently, in both desirable and undesirable contexts, in a wide variety of practical disciplines, products, and industrial processes. The field of colloids also overlaps heavily with the field of nanotechnology. The problems associated with colloids are usually interdisciplinary in nature, and a broad scientific base is required to understand them completely. This article provides an introduction to the field of colloids, emphasizing the wide range of practical and industrial applications.
Fillers and Filled Plastics
Authors: DeArmitt Chris 
Published: June 2019

Abstract
Functional fillers are used to enhance the intrinsic properties of plastics and to impart entirely new effects. Addition of a filler changes many properties at once, so successful formulation depends on an understanding of structure–property relationships in order to maximize the desirable effects and minimize any detrimental changes.
This article gives guidance on the selection of ingredients, that is, polymers, fillers, and surface treatments, as well as on aspects related to their processing and influence on the performance of the final part. The reader will gain a firm grasp of the topic as well as suggestions for further reading. Some myths and misunderstandings are explained, and new insights into filled plastics are revealed.
When One Genome Is Not Enough: Organellar Heteroplasmy in Plants
Authors: Ramsey Adam J. , Mandel Jennifer R. 
Published: June 2019

AbstractHeteroplasmy occurs when copies of an organellar genome (plastid or mitochondrial) differ from one another either within a cell or among cells within an individual. This phenomenon was first discovered in plastids over 100 years ago, though ‘heteroplasmy’ was not formally defined until decades later. Mitochondrial and plastid heteroplasmy have since been discovered in diverse taxa, including numerous plants, particularly those with the gynodioecious breeding system. Though heteroplasmy can arise through mutations in organellar genomes, biparental inheritance of organelles often generates heteroplasmy. This article is intended to summarise the cytoploid nature of organellar genomes and different aspects of mitochondrial and plastid heteroplasmy, from its discovery, to the development of detection methods. We will also discuss the effects of heteroplasmy on individuals, populations, and species, with regard to fitness, cytonuclear interactions, and genome evolution. Finally, we highlight a few research questions which we consider in need of further investigation to understand the prevalence and effects of heteroplasmy in natural settings.
Clinical and molecular findings in a cohort of ANO5‐related myopathy
Authors: Silva André M. S. , Coimbra-Neto Antônio R. , Souza Paulo Victor S. , Winckler Pablo B. , Gonçalves Marcus V. M. , Cavalcanti Eduardo B. U. , Carvalho Alzira A. D. S. , Sobreira Cláudia F. D. R. , Camelo Clara G. , Mendonça Rodrigo D. H. , Estephan Eduardo D. P. , Reed Umbertina C. , Machado-Costa Marcela C. , Dourado-Junior Mario E. T. , Pereira Vanessa C. , Cruzeiro Marcelo M. , Helito Paulo V. P. , Aivazoglou Laís U. , Camargo Leonardo V. D. , Gomes Hudson H. , Camargo Amaro J. S. D. , Pinto Wladimir B. V. D. R. , Badia Bruno M. L. , Libardi Luiz H. , Yanagiura Mario T. , Oliveira Acary S. B. , Nucci Anamarli , Saute Jonas A. M. , França-Junior Marcondes C. , Zanoteli Edmar 
Published: June 2019

AbstractObjectiveANO5‐related myopathy is an important cause of limb‐girdle muscular dystrophy (LGMD) and hyperCKemia. The main descriptions have emerged from European cohorts, and the burden of the disease worldwide is unclear. We provide a detailed characterization of a large Brazilian cohort of ANO5 patients.MethodsA national cross‐sectional study was conducted to describe clinical, histopathological, radiological, and molecular features of patients carrying recessive variants in ANO5. Correlation of clinical and genetic characteristics with different phenotypes was studied.ResultsThirty‐seven patients from 34 nonrelated families with recessive mutations of ANO5 were identified. The most common phenotype was LGMD, observed in 25 (67.5%) patients, followed by pseudometabolic presentation in 7 (18.9%) patients, isolated asymptomatic hyperCKemia in 4 (10.8%) patients, and distal myopathy in a single patient. Nine patients presented axial involvement, including one patient with isolated axial weakness. The most affected muscles according to MRI were the semimembranosus and gastrocnemius, but paraspinal and abdominal muscles, when studied, were involved in most patients. Fourteen variants in ANO5 were identified, and the c.191dupA was present in 19 (56%) families. Sex, years of disease, and the presence of loss‐of‐function variants were not associated with specific phenotypes.InterpretationWe present the largest series of anoctaminopathy outside Europe. The most common European founder mutation c.191dupA was very frequent in our population. Gender, disease duration, and genotype did not determine the phenotype.