bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mount Meron infrasound array: an infrasound array without a noise reduction system
Authors: Averbuch Gil , Ben-Horin Yochai , Smets Pieter S M , Evers Läslo G 
Published: July 2019

SUMMARYMeasurements of seismo-acoustic events by collocated seismic and infrasound arrays allow for studying the two wavefields that were produced by the same event. However, some of the scientific and technical constraints on the building of the two technologies are different and may be contradicting. For the case of a new station, an optimal design that will satisfy the constraints of the two technologies can be found. However, in the case of upgrading an existing array by adding the complementing technology, the situation is different. The site location, the array configuration and physical constraints are fixed and may not be optimal for the complementing technology, which may lead to rejection of the upgrade. The International Monitoring System (IMS) for the verification of the Comprehensive Nuclear-Test-Ban Treaty (CTBT) includes 37 seismic arrays and 51 infrasound arrays. Although the CTBT verification regime is fixed in the treaty, an upgrade of the existing arrays by adding more technologies is possible.The Mount Meron seismic array (MMAI), which is part of the IMS, is composed of 16 sites. Microbarometers were installed at five MMAI sites to form the Mount Meron infrasound array. Due to regulation and physical constraints, it was not possible to relocate the sites nor to install analogue noise reduction filters (i.e. a pipe array). In this study, it is demonstrated that the installation of the MMAI infrasound array is beneficial despite the non-optimal conditions. It is shown that the noise levels of the individual array sites are between the high and median global noise levels. However, we claim that the more indicative measures are the noise levels of the beams of interest, as demonstrated by analysing the microbaroms originated from the Mediterranean Sea. Moreover, the ability to detect events relevant to the CTBT is demonstrated by analysing man-made events during 2011 from the Libya region.
Voltage-gated proton channels exist in the plasma membrane of human oocytes
Authors: Smith R Ya , Morgan D , Sharma L , Cherny V V , Tidswell N , Molo M W , DeCoursey T E 
Published: July 2019

AbstractSTUDY QUESTIONDo human oocytes express voltage-gated proton channels?SUMMARY ANSWERHuman oocytes exhibit voltage-gated proton currents.WHAT IS KNOWN ALREADYVoltage-gated proton currents have been reported in human sperm, where they contribute to capacitation and motility. No such studies of human oocytes exist.STUDY DESIGN, SIZE, DURATIONVoltage-clamp studies were undertaken using entire oocytes and vesicles derived from oocytes and in excised patches of membrane from oocytes.PARTICIPANTS/MATERIALS, SETTING, METHODSFrozen, thawed human metaphase II oocytes were obtained from material donated to the gamete repository at the Rush Center for Advanced Reproductive Care. Prior to patch clamping, oocytes were warmed and equilibrated. Formation of an electrically tight seal requires exposing bare oolemma. Sections of the zona pellucida (ZP) were removed using a laser, followed by repeated pipetting, to further separate the oocyte from the ZP. Patch-clamp studies were performed using the whole-cell configuration on oocytes or vesicles derived from oocytes, and using inside-out patches of membrane, under conditions optimized to detect voltage-gated proton currents.MAIN RESULTS AND THE ROLE OF CHANCEProton currents are present at significant levels in human oocytes where they exhibit properties similar to those reported in other human cells, as well as those in heterologous expression systems transfected with the HVCN1 gene that codes for the voltage-gated proton channel.LARGE SCALE DATAN/ALIMITATIONS, REASONS FOR CAUTIONHuman oocytes are large cells, which limits our ability to control the intracellular solution. Subtle effects of cryopreservation by vitrification and subsequent warming on properties of HVCN1, the HVCN1 gene product, cannot be ruled out.WIDER IMPLICATIONS OF THE FINDINGSPossible functions for voltage-gated proton channels in human oocytes may now be contemplated.STUDY FUNDING/COMPETING INTEREST(S)NIH R35GM126902 (TED), Bears Care (DM). No competing interests.TRIAL REGISTRATION NUMBERN/A.
Emergent threats: lessons learnt from Ebola
Authors: Piot Peter , Soka Moses J , Spencer Julia 
Published: July 2019

Abstract
Recent disease outbreaks have demonstrated the severe health, economic and political crises that epidemics can trigger. The rate of emergence of infectious diseases is accelerating and, with deepening globalisation, pathogens are increasingly mobile. Yet the 2014–2015 West African Ebola epidemic exposed major gaps in the world’s capacity to prevent and respond to epidemics. In the midst of the world’s second largest ever recorded Ebola outbreak in the Democratic Republic of the Congo, we reflect on six of the many lessons learnt from the epidemic in West Africa, focusing on progress made and the challenges ahead in preparing for future threats. While Ebola and other emerging epidemics will remain a challenge in the years to come, by working in partnership with affected communities and across sectors, and by investing in robust health systems, it is within our power to be better prepared when they strike.
Shared decision making in musculoskeletal pain consultations in low- and middle-income countries: a systematic review
Authors: Sam Sreya , Sharma Radha , Corp Nadia , Igwesi-Chidobe Chinonso , Babatunde Opeyemi O 
Published: July 2019

Abstract

Background
Global populations, especially those in low- and middle-income countries (LMICs), are at an increased risk of musculoskeletal (MSK) pain, a leading cause of years lived with disability. Shared decision making (SDM) in the management of these conditions may drive improvements in healthcare outcomes and quality. This study aimed to synthesize and appraise available evidence regarding SDM in MSK pain consultations in LMICs.

Methods
Comprehensive literature searches were conducted in 12 databases for primary studies investigating SDM in MSK pain consultations across all healthcare and community settings in LMICs. Study eligibility screening, data extraction and quality appraisal (using the Critical Appraisals Skills Programme tool) were completed by pairs of reviewers. Findings were brought together using thematic synthesis of data from all the primary studies.

Results
Seven studies (mostly moderate quality) were included. There was low awareness of SDM among healthcare professionals (HCPs); however, this is not explicitly practised due to cultural and operational barriers. HCP training and patient empowerment through health literacy were proposed facilitators. The traditional paternalistic approach to treatment poses a key barrier to SDM, decreases adherence to prescribed treatments and raises the risk of poor clinical outcomes.

Conclusions
SDM is still a relatively ‘foreign concept’ within consultations and management of MSK pain patients in LMICs. There is a dearth of research in SDM and patient-centred care. Given the socio-economic impact of MSK pain, further research into the value of SDM in LMIC healthcare settings requires further consideration.
Assessment of microchimerism following somatic cell nuclear transfer and natural pregnancies in goats
Authors: Gash Kirsten K , Yang Min , Fan Zhiqiang , Regouski Misha , Rutigliano Heloisa M , Polejaeva Irina A 
Published: July 2019

AbstractMicrochimerism is defined as the presence of a small population of cells or DNA in 1 organism originated from a genetically different organism. It is well established that this phenomenon occurs in humans and mice as cells are exchanged between mother and fetus during gestation. Currently, no information is available about the presence of maternal microchimerism in goats, and the only published study is limited to an evaluation of fetal and fetal–fetal microchimerism in blood samples following natural breeding. In order to determine whether bidirectional fetal–maternal cell or DNA trafficking occurs in goats, we assessed: 1) fetal microchimerism in surrogates that gave birth to somatic cell nuclear transfer (SCNT)-derived transgenic offspring (n = 4), 2) maternal microchimerism following natural breeding of SCNT-derived transgenic does with a nontransgenic buck (n = 4), and 3) fetal–fetal microchimerism in nontransgenic twins of transgenic offspring (n = 3). Neomycin-resistance gene (NEO) gene was selected as the marker to detect the presence of the αMHC-TGF-β1-Neo transgene in kidney, liver, lung, lymph node, and spleen. We found no detectable maternal or fetal–fetal microchimerism in the investigated tissues of nontransgenic offspring. However, fetal microchimerism was detected in lymph node tissue of one of the surrogate dams carrying a SCNT pregnancy. These results indicate occurrence of cell trafficking from fetus to mother during SCNT pregnancies. The findings of this study have direct implications on the use and disposal of nontransgenic surrogates and nontransgenic offspring.
Family-Based Consent and Motivation for Cadaveric Organ Donation in China: An Ethical Exploration1
Authors: Fan Ruiping , Wang Mingxu 
Published: July 2019

AbstractThis essay indicates that Confucian family-based ethics is by no means a stumbling block to organ donation in China. We contend that China should not change to an opt-out consent system in order to enhance donation because a “hard” opt-out system is unethical, and a “soft” opt-out system is unhelpful. We argue that the recently-introduced familist model of motivation for organ donation in mainland China can provide a proper incentive for donation. This model, and the family priority right that this model supports, is ethically justifiable in terms of Confucian family-based ethics.
Dynamics of dusty vortices – I. Extensions and limitations of the terminal velocity approximation
Authors: Lovascio Francesco , Paardekooper Sijme-Jan 
Published: July 2019

ABSTRACT
Motivated by the stability of dust laden vortices, in this paper we study the terminal velocity approximation equations for a gas coupled to a pressureless dust fluid and present a numerical solver for the equations embedded in the FARGO3D hydrodynamics code. We show that for protoplanetary discs it is possible to use the barycentre velocity in the viscous stress tensor, making it trivial to simulate viscous dusty protoplanetary discs with this model. We also show that the terminal velocity model breaks down around shocks, becoming incompatible with the two-fluid model it is derived from. Finally we produce a set of test cases for numerical schemes and demonstrate the performance of our code on these tests. Our implementation embedded in FARGO3D using an unconditionally stable explicit integrator is fast, and exhibits the desired second-order spatial convergence for smooth problems.
Full-3D relativistic MHD simulations of bow shock pulsar wind nebulae: emission and polarization
Authors: Olmi B , Bucciantini N 
Published: July 2019

ABSTRACT
Bow shock pulsar wind nebulae are observed with a variety of complex morphologies at different wavelengths, most likely due to differences in the magnetic field strength and pulsar wind geometry. Here we present a detailed analysis, showing how these differences affect the observational properties in these systems, focusing on non-thermal synchrotron emission. By adopting different prescriptions for the local emissivity, on top of the magnetic and flow patterns taken from three-dimensional (3D) high-resolution numerical simulations in relativistic magnetohydrodynamics (MHD), and considering various viewing angles, we try to characterize the main features of the emission and polarization, to verify if and how these can be used to get information, or to put constraints, on known objects. We found, for example, that conditions leading to a strong development of the turbulence in the bow shock tail produce substantial differences in the emission pattern, especially in polarized light.
Detection of a slow H i bar in the dwarf irregular galaxy DDO 168
Authors: Patra Narendra Nath , Jog Chanda J 
Published: July 2019

Abstract
We examine the H i total intensity maps of the VLA LITTLE-THINGS galaxies and identify an H i bar in the dwarf irregular galaxy DDO 168 which has a dense and compact dark matter halo that dominates at all radii. This is only the third galaxy found to host an H i bar. Using the H i kinematic data, we apply the Tremaine–Weinberg method to estimate the pattern speed of the bar. The H i bar is found to have an average pattern speed of 23.3 ± 5.9 $\rm km \, s^{-1} \, kpc^{-1}$. Interestingly, for the first time, we find that the observed pattern speeds of the bar in the two kinematic halves are different. We identify the origin of this difference to be the kinematic asymmetry. This observed offset in the pattern speed serves to put a stringent constraint on the lifetime of the bar set by the winding time-scale. The lifetime of the bar is found to be 5.3 × 108 yr, which is two times the dynamical time-scale of the disc. We also find the H i bar in DDO 168 to be a weak bar with a strength of 0.2. If H i bar being weak can be easily disturbed, this could possibly explain why it is extremely rare to observe H i bars in galaxies. We estimate the bar radius to be 1 kpc and the dimensionless ratio, RL/Rb to be ≥2.1 indicating a ‘slow’ bar in DDO 168. Our results confirm the proposition that the dynamical friction with the halo slows down a rotating bar in a galaxy dominated by dark matter halo from inner radii.
Completion of LINE integration involves an open ‘4-way’ branched DNA intermediate
Authors: Khadgi Brijesh B , Govindaraju Aruna , Christensen Shawn M 
Published: July 2019

AbstractLong Interspersed Elements (LINEs), also known as non-LTR retrotransposons, encode a multifunctional protein that reverse transcribes its mRNA into DNA at the site of insertion by target primed reverse transcription. The second half of the integration reaction remains very poorly understood. Second-strand DNA cleavage and second-strand DNA synthesis were investigated in vitro using purified components from a site-specific restriction-like endonuclease (RLE) bearing LINE. DNA structure was shown to be a critical component of second-strand DNA cleavage. A hitherto unknown and unexplored integration intermediate, an open ‘4-way’ DNA junction, was recognized by the element protein and cleaved in a Holliday junction resolvase-like reaction. Cleavage of the 4-way junction resulted in a natural primer-template pairing used for second-strand DNA synthesis. A new model for RLE LINE integration is presented.
The effects of youth labour market reforms: evidence from Italian apprenticeships
Authors: Albanese Andrea , Cappellari Lorenzo , Leonardi Marco 
Published: July 2019

AbstractIn this paper, we estimate the causal effects of the 2003 reforms to the Italian apprenticeship contract that increased its legal length, allowed on-the-job training and introduced a minimum floor to apprentices’ wages. Using administrative data, we implement a covariate balancing propensity score and a difference-in-differences estimator. We find that the new contract improves the chances of an apprentice obtaining a permanent job in the same firm five years after hiring; however, this occurs more frequently in large firms. We also find sizeable, long-run wage effects that extend well beyond the legal duration of the apprenticeship contract. These effects are compatible with increased human capital accumulation, possibly due to the reformed training provisions.
Select Committee Reform: Shifting the Balance and Pushing the Boundaries
Authors: Maer Lucinda 
Published: July 2019

Abstract
The departmental select committee system, established in 1979, is seen as increasingly powerful, with committees producing more work, engaging with more people, and doing more to scrutinise the actions of those with power than ever before. There have been two main periods of select committee reform over the past 40 years: the first following the 2001 general election, and the second in the run-up to the 2010 general election. More recently, select committees, strengthened by the election of their chairs and members, have pushed at the boundaries of their powers and remit. This article sets out the story of reform.
From Hólar to Lisbon: Middle English Literature in Medieval Translation, c.1286–c.1550
Authors: Byrne Aisling 
Published: July 2019

Abstract
This paper offers the first survey of evidence for the translation of Middle English literature beyond the English-speaking world in the medieval period. It identifies and discusses translations in five vernaculars: Welsh, Irish, Old Norse-Icelandic, Dutch, and Portuguese. The paper examines the contexts in which such translation took place and considers the role played by colonial, dynastic, trading, and ecclesiastical networks in the transmission of these works. It argues that English is in the curious position of being a vernacular with a reasonable international reach in translation, but often with relatively low literary and cultural prestige. It is evident that most texts translated from English in this period are works which themselves are based on sources in other languages, and it seems probable that English-language texts are often convenient intermediaries for courtly or devotional works more usually transmitted in French or Latin.
Why Does an IPO Affect Rival Firms?
Authors: Spiegel Matthew , Tookes Heather 
Published: July 2019

Abstract
IPO firms’ rivals tend to experience performance declines following an IPO in the industry. Why? We estimate a dynamic structural oligopoly model to distinguish between alternative theories that can explain an industry’s evolution post-IPO. We find that most changes in rivals’ performance are due to industry trends that also drive IPOs. However, we also find some “competitive” IPOs where the IPO enhances the IPO firm’s performance at the expense of competitors. These findings help reconcile prior evidence of average performance reductions of both IPO firms and their rivals with well-known cases in which firms have benefited from going public. (JEL G30, G32)
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Significant association between clinical characteristics and immuno-phenotypes in patients with ANCA-associated vasculitis
Authors: Matsumoto Kotaro , Suzuki Katsuya , Yoshimoto Keiko , Seki Noriyasu , Tsujimoto Hideto , Chiba Kenji , Takeuchi Tsutomu 
Published: July 2019

AbstractObjectivesTo elucidate the association between clinical characteristics and immuno-phenotypes in patients with ANCA-associated vasculitis (AAV).MethodsPeripheral blood from 36 patients with active AAV and 18 healthy controls was examined for numbers of circulating T cells, B cells, NK cells, dendritic cells, monocytes and granulocytes using flow cytometry. These immuno-phenotyping data were subjected to cluster analysis and principal components analysis to divide AAV patients into subgroups. Associated organ involvement or therapeutic prognosis were assessed for each subgroup.ResultsAAV patients had higher proportions of plasma cells, plasmablasts, activated T cells, CD14++ CD16+ monocytes, eosinophils and neutrophils than healthy controls. Immuno-phenotyping findings were similar between patients with microscopic polyangiitis, granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis. Cluster analysis indicated that AAV patients could be divided into three subgroups according to peripheral immune cell numbers: antibody production-related (n = 9), cytotoxic activity-related (n = 4) and neutrocytosis/lymphocytopenia-related (n = 23). The antibody production-related or cytotoxic activity-related group was associated with CNS involvement, and the neutrocytosis/lymphocytopenia-related group was associated with high incidence of kidney involvement. Incidence of severe infection was markedly higher in the neutrocytosis/lymphocytopenia-related group than the other two groups. Incidence of disease relapse was comparable among the three groups.ConclusionPatients with active AAV can be divided into three subgroups based on immuno-phenotyping. These results may provide a hint to understanding disease pathophysiology and prognosis, and determining appropriate treatment.
Long-term follow-up of patients in the TIght COntrol of inflammation in early Psoriatic Arthritis (TICOPA) trial
Authors: Coates Laura C , Mahmood Farrouq , Freeston Jane , Emery Paul , Conaghan Philip G , Helliwell Philip S 
Published: July 2019

Abstract

Objectives
The TIght COntrol of inflammation in early Psoriatic Arthritis (TICOPA) study was the first strategy trial in psoriatic arthritis using an early treat-to-target strategy to improve clinical outcomes. The current study aimed to review a cohort of patients who had completed TICOPA to judge if the clinical advantage gained by participants in the tight control (TC) arm was sustained, and to explore subsequent therapy.

Methods
A case note review was conducted for a cohort of patients who had participated in TICOPA. Current drug use and clinical status were obtained, with low disease activity judged as no tender or swollen joints, no dactylitis and enthesitis, and no change in treatment required.

Results
Approximately five years after completion of the TICOPA study, notes were reviewed for 110 patients [TC, n = 54; standard care (StdC), n = 56]. Disease activity was found to be similar in both groups (current low disease activity: TC 69%, StdC 76%). Biologic use at the end of the study was higher in the TC arm (TC 33%, StdC 9%), but at review a similar percentage in both groups were taking biologic drugs (TC 54%, StdC 52%), whereas MTX use diminished.

Conclusion
After several years, clinical outcomes and therapeutic drug use were similarly good for patients in both arms of the TICOPA study, with no obvious clinical advantage after TC ended. Notably, TC did not result in greater biological use long term, and MTX use decreased in both arms of the study.
Shooting a high-density electroencephalographic picture on sleep in children with attention-deficit/hyperactivity disorder
Authors: Miano Silvia , Amato Ninfa , Garbazza Corrado , Abbafati Manuel , Foderaro Giuseppe , Pezzoli Valdo , Ramelli Gian Paolo , Manconi Mauro 
Published: July 2019

Abstract

Study Objectives
Sleep-related slow-wave activity (SWA) has been recognized as a marker of synaptic plasticity. In children affected by attention deficit hyperactivity disorder (ADHD), SWA is mainly located in the central rather than frontal regions, reflecting a maturational delay. A detailed subjective and objective sleep investigation, including a full night video-polysomnography (PSG-HD-EEG), was performed on 30 consecutive drug naïve outpatients with a diagnosis of ADHD. They received a diagnosis of sleep disorders in 29/30 cases, and most of them had a past history of sleep problems. They had a higher apnea–hypopnea index at PSG, and slept less than 9 hr at actigraphy. We aimed to describe the SWA behavior in the same group of children with ADHD.

Materials and Methods
The full-night PSG-HD EEG of children with ADHD was compared with the one of the 25 healthy controls. The scalp SWA mapping, the decrease of SWA during the night, and the EEG source of SWA were analyzed.

Results
At scalp topography, the focus of SWA was observed over the centro–parietal–occipital regions in participants with ADHD (p < 0.01), which remained significant in the subgroups divided between subgroups according to the sleep diagnosis (p < 0.01). The physiological decrease in SWA was more evident in control participants. The source analysis revealed a greater delta power over the posterior cingulate in participants with ADHD (p < 0.01).

Conclusions
Our results confirm static and dynamic changes in SWA behavior in children with ADHD, which may reflect a maturational delay occurring at a vulnerable age, as a consequence of chronic sleep deprivation.