bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular Stress Markers Following Inhalation of Heated Tobacco Products: A Study on Extracellular Vesicles
Authors: Antoniewicz Lukasz , Melnikov Georgy , Lyytinen Gustaf , Blomberg Anders , Bosson Jenny A. , Hedman Linnea , Mobarrez Fariborz , Lundbäck Magnus 
Published: October 2024

Abstract
The advent of heated tobacco products (HTPs) has introduced new variables in the study of nicotine delivery systems and their health implications. Amidst concerns over cardiovascular effects, this study aims to elucidate the acute impact of HTP inhalation on extracellular vesicles (EV) levels in young, healthy individuals. In this controlled, acute exposure study, 23 young, healthy volunteers were subjected to HTP inhalation. EV levels of endothelial and platelet origin were quantified through flow cytometry before and after exposure. Data analysis was performed using multiple measures ANOVA to assess changes in EV concentrations. Our findings reveal a significant increase in EVs of endothelial and platelet origin following short-term HTP inhalation with nicotine. Notably, no significant change was observed in leukocyte- and neutrophil-derived EVs. This increase in EVs suggests acute vascular stress, with peak levels observed 4 h post-exposure. The rise in endothelial and platelet-derived EVs aligns with documented responses to acute vascular injury, paralleling the effects seen with traditional cigarette and e-cigarette use. Despite HTPs being marketed as safer alternatives, our results indicate that nicotine-containing HTPs may still pose significant vascular risks. These findings contribute to the growing body of evidence cautioning against the perceived safety of HTPs and reinforce the importance of regulatory oversight and public health initiatives targeting nicotine delivery technologies. Trial Registrations: ClinicalTrials.gov ID: NCT04824495, registered 2021–01-07.
Too many spines, or an integrative foundation of the Echiniscus spinulosus morphogroup (Heterotardigrada: Echiniscidae)
Authors: Gąsiorek Piotr , Sørensen Martin V. 
Published: October 2024

AbstractHistorical taxonomic bias has started to be effectively removed in tardigrade taxonomy in the last two decades by the application of modern statistical, genetic and morphological tools. Many of the “old” tardigrade taxa have been redefined, and their succinct original diagnoses—refined, finally resulting in making them properly identifiable and less enigmatic. At the same time, many of the “old” species were synonymised and perished in the taxonomic wastebasket. Herein, we address the species distinction between Echiniscus spiniger Richters, 1904 and Echiniscus spinulosus (Doyère, 1840) by means of integrative analyses of 11 European populations collected in the Mediterranean, the Carpathians and the Baltic Sea islands of Öland and Gotland, covering the southern distribution zone and northernmost known localities within trustworthy geographic range of these species. We disclose that, as previously hypothesised, E. spiniger is conspecific with E. spinulosus, and synonymised accordingly. We deliver morphological evidence supporting the triphyly of the morphogroup, with all tropical and subtropical species truly lacking intracuticular pillars, whereas the Palaearctic lineage corresponding solely to E. spinulosus and Afrotropical lineage represented by E. belloporus Gąsiorek and Kristensen, 2018—occasionally exhibiting pillars in some specimens. A synopsis and key to all representatives of the E. spinulosus morphogroup are provided, pinpointing to some problems that must be taken into consideration during identification and solved in the future.
A classification scheme for urban agriculture combining technical properties with characteristics related to the economic and social sustainability
Authors: Douziech Mélanie , Mann Stefan , Galley Stefan , Lansche Jens 
Published: October 2024

AbstractUrban agriculture is often associated with sustainable agricultural practices. However, the variety of systems qualifying as urban agriculture and the limited information available about their sustainability question this direct relationship. To better understand differences in intra-urban agriculture systems and their sustainability, this paper proposed an holistic classification of urban agricultural systems and collected knowledge about the environmental, social, and economic sustainability of these systems. Such a classification is important to evaluate sustainability claims on urban agricultural systems, anticipate potential sustainability trade-offs between urban agricultural systems and propose preventive measures to address these, and ultimately guide the sustainable deployment of these systems. Compared with existing classifications, the novel classification scheme proposed here accounts for technological, social and economic characteristics of urban agriculture systems to better distinguish between all systems. It was built on 91 scientific papers. The economic intensity of production was, for example, an important characteristic to coherently group urban agriculture systems. The intensity of cooperation between all actors was another characteristic emphasized for certain urban agriculture systems. One end of the classification scheme describes ground-based open, socially motivated urban agriculture systems with high cooperation intensity and low production intensity. The other end of the classification scheme describes building-integrated quasi-closed systems with high production intensity. In between, we find: building-integrated conditioned systems, ground-based conditioned systems, and building-integrated open systems. Mapping sustainability claims from literature in the classification scheme supported its definition along the three characteristics. For example, urban farming was associated with job creation, food safety, water savings, and higher yields while urban gardening with educational potentials, biodiversity improvements, and lower yields. Their display in the classification scheme was therefore supported. To further support the use of the proposed scheme, additional quantitative research to better understand and quantify the sustainability of urban agriculture systems is required.
Comparative Analysis of Tsunami Casualty Estimation Approaches: Agent-Based Modeling versus Simplified Approach in Japanese Coastal Cities
Authors: Takabatake Tomoyuki , Hasegawa Nanami , Yamaguchi Keita , Esteban Miguel 
Published: October 2024

AbstractEstimating potential casualties from a significant earthquake and tsunami event is crucial to enhance disaster preparedness and response. Although various approaches exist to assess potential casualties, few studies have made direct comparisons between them. The present study aimed to clarify the differences in the estimation of casualties between an agent-based model (ABM), which can capture detailed evacuation behavior but demands significant computational resources, and a simplified approach at less computational cost by assuming that evacuees would move along a straight line from their initial location to the closest evacuation destination. These different approaches were applied to three coastal cities in Japan—Mihama, Kushimoto, and Shingu in Wakayama Prefecture—revealing significant differences in the estimated results between the ABM and the simplified approach. Notably, when the effects of building collapse due to an earthquake were considered, the mortality rates estimated by the ABM were higher than those estimated by the simplified approach in the three cities. There were also significant differences in the spatial distribution of the estimated mortality rates between the ABM and the simplified approach. The findings suggest that while the simplified approach can yield results more quickly, casualty estimates derived from such models should be interpreted with caution.
Enhancing the MCL-SLAM algorithm to overcome the issue of illumination variation, non-static environment and kidnapping to present the NIK-SLAM
Authors: Agunbiade Olusanya Yinka 
Published: October 2024

AbstractSimultaneous Localization and Mapping (SLAM) is a major challenge that has been comprehensively investigated by scholars. SLAM’s ability to support autonomous navigation helps the robot to move from one place to another without being controlled by humans. This achievement has attracted the attention of scholars towards focusing on this area. Over the decades, countless procedures have been developed with extraordinary accomplishments. However, some problems can degrade the efficiency of SLAM (Simultaneous Localization and Mapping) technique, and examples of such problems include environmental noises (light intensity and shadow), non-static environment, and kidnap robots. These problems create inconsistency in measurement that can lead to erroneous navigation for an unmanned vehicle. In minimizing the effect of these problems, a novel SLAM technique based on several re-modifications of MCL is presented in this paper. This innovative technique is known as NIK-SLAM. The NIK-SLAM is equipped with filters alongside some modifications of the original Monte-Carlo algorithm (MCL) to maximize its performance. The filters were employed to overcome the effect of shadow and light intensity while the re-modification of MCL is used to overcome the limitation of kidnapping and non-static objects. A publicly available dataset (TUM-RGBD) and a private dataset were used for evaluation. Matlab was used for simulation while assessments were based on quantitative and qualitative validation. The results demonstrated a better performance of the NIK-SLAM, attaining a lower trajectory error for most experiments when compared to the original MCL and other SLAM algorithms found in the literature, but at the expense of delayed processing time. Furthermore, this accomplishment supports pathway planning, and exploration into unstable environments while it decreases accident rates/human fatalities, and in the future study, the issue of delayed processing time will be addressed.
Post-Bruner Reflections on the Human Mind
Authors: Klempe Sven Hroar 
Published: October 2024

AbstractAfter a short presentation of some key aspects of Jerome Bruner’s theories of the mind, this paper aims to assess his thinking on the mind in light of a broader context. This is done from three different angles: (1) By focusing on Roman Jakobson’s theories about language, which Bruner refers to. (2) By bringing in some post-structuralist perspectives that problematize narratives and logocentric entrenchments in scientific thinking. (3) By analyzing the eighteenth-century German discussion among Christian Wolff, Alexander Gottlieb Baumgarten and Immanuel Kant about the role of metaphysics in their understanding of psychology. The findings indicate that Roman Jakobson, with his poetic understanding of language, may point to a valid path for future research on the mind. Moreover, Jakobson’s understanding is also compatible with Baumgarten’s use of poetic aspects. Both manage to subvert the logocentric aspect of humans’ use of language and by this demonstrate how metacognition has to be understood through esthetic functions that go beyond a logocentric use of language. The Wolffian emphasis on mathematics and logic in Wolff’s understanding of psychology is comparable with many of the premises for the cognitive revolution in the 1950s. The Kantian focus on concepts and rule-governed understanding also points in this direction. Bruner seems to ignore the historical background for discussions of psychology in the twentieth century, and because of this has problems moving beyond the logocentric premises that govern most of the cognitive sciences.
Enhancement of the anaerobic biodegradation efficiency of azo dye by anthraquinone-loaded biochar biofilm: factors affecting biofilm formation and the enhancement mechanism
Authors: Wang Guangyuan , Cui Chenhao , Wang Yuqian , Pang Jiwei , Yang Shanshan , Wu Chuandong , Fang Rui , Zhang Luyan , Ren Nanqi , Ding Jie 
Published: October 2024

AbstractCarbon-based materials that serve as microbial carriers, and the role of surface-formed biofilms in anaerobic digestion, merit further investigation. This study explored the role and mechanism behind the biodegradation enhancement of biofilms formed onto anthraquinone-loaded biochar (AQS-BC) surfaces through the anaerobic decolorization process of azo dye Reactive Red 2, and optimized the conditions for AQS-BC biofilm formation. The results indicated that the AQS-BC biofilm system exhibited high treatment efficiency and stability in RR2 anaerobic decolorization. RR2 led to the accumulation of volatile fatty acids (VFAs) and inhibition of methane production, while the presence of AQS increased methane production. The effects of sludge concentration, contact time, carbon source concentration, and RR2 concentration on biofilm maturity were also analyzed. Combining biochemical characteristics, electrochemical properties, surface structure, and microbial community analysis, a mechanism for the anaerobic decolorization of RR2 via AQS-BC as a microbial carrier was proposed. This study provides insights into the roles of biofilms in the anaerobic wastewater treatment processes.
Graphical Abstract
Blending BDI Agents with Object-Oriented and Functional Programming with JaKtA
Authors: Baiardi Martina , Burattini Samuele , Ciatto Giovanni , Pianini Danilo 
Published: October 2024

AbstractThe popularity of multi-paradigm languages is on the rise, enabling developers to select the most appropriate paradigm for each task. While object-oriented and functional programming are commonly combined, other paradigms can also be hybridized. This paper introduces JaKtA, an internal Domain-Specific Language designed to support the definition of Belief-Desire-Intention agents in Kotlin. Our work represents an initial exploration into blending Agent-Oriented Programming with other prevalent paradigms, emphasizing the potential benefits of using internal Domain-Specific Languages. We demonstrate, through JaKtA, how this approach facilitates the creation of compact and expressive Belief-Desire-Intention agents that seamlessly integrate with the host language, its libraries, and tooling.
Comparison of current and proposed travel modes for students considering travelling and sustainable indicators
Authors: Farooq Abdus Samad , Akhtar Ayesha , Javid Muhammad Ashraf , Zafar Sameer , Khan Zahid Ullah 
Published: October 2024

AbstractIn the twenty-first century, global warming has become one of the severe challenges. Around one-fourth of the total carbon footprint is contributed by transport vehicles. It is crucial to provide alternative solutions to unsustainable transportation systems. This study compares the present travel modes of students of the Capital University of Science and Technology, Islamabad, with the proposed sustainable travel mode. A campus survey (N = 565) was conducted to understand travel choices, travel times, origin and destinations, and student preferences, considering university buses and private vehicles. A comparison was made between the travel time analysis of university bus users and non-bus users. A sustainability analysis has been conducted to evaluate the effects of the present travel modes on students and the proposed university bus transport system. Five main factors were compared: fuel consumption and associated fuel costs, carbon and vehicular emissions, traffic noise pollution, traffic congestion, and accident ratio. The results show that 38% of students commute by private cars and 18% by motorbikes. Around 25% of the students avoid university buses due to long travel times, and 30% prefer because their parents ask them. On average, university buses take 56.8 min, and non-bus transports take 38.8 min for one-way travel. If all students travel by university busses, they could be 86% more sustainable in fuel costs and carbon emissions than non-bus travel modes. These results give useful policy implications for providing sustainable travel alternatives to educational institutions.
Zinc metalloprotease FgM35, which targets the wheat zinc-binding protein TaZnBP, contributes to the virulence of Fusarium graminearum
Authors: Wang Xin-tong , Liu Kou-han , Li Ying , Ren Yan-yan , Li Qiang , Wang Bao-tong 
Published: October 2024

AbstractMetalloproteinases are ubiquitous in organisms. Most metalloproteinases secreted by pathogenic microorganisms are also called virulence factors, because they degrade proteins in the external tissues of the host, thereby reducing the host’s immunity and increasing its susceptibility to disease. Zinc metalloproteinase is one of the most common metalloproteinases. In our report, we studied the biological function of zinc metalloprotease FgM35 in Fusarium graminearum and the pathogen–host interaction during infection. We found that the asexual and sexual reproduction of the deletion mutant ΔFgM35 were affected, as well as the tolerance of F. graminearum to metal stress. In addition, deletion of FgM35 reduced the virulence of F. graminearum. The wheat target TaZnBP was screened using a wheat yeast cDNA library, and the interaction between FgM35 and TaZnBP was verified by HADDOCK molecular docking, yeast two-hybrid, Bi-FC, Luc, and Co-IP assays. The contribution of TaZnBP to plant immunity was also demonstrated. In summary, our work revealed the indispensable role of FgM35 in the reproductive process and the pathogenicity of F. graminearum, and it identified the interaction between FgM35 and TaZnBP as well as the function of TaZnBP. This provides a theoretical basis for further study of the function of metalloproteinases in pathogen–host interactions.
Sustainable transformation of end-of-life tyres into value-added products using thermochemical processes
Authors: Han Bing , Kumar Dileep , Pei Yang , Norton Michael , Adams Scott D. , Khoo Sui Yang , Kouzani Abbas Z. 
Published: October 2024

AbstractThe end-of-life tyres (ELTs) are currently critical environmental and societal problems due to their large quantity and chemical structure. The thermochemical process has been acknowledged as a viable option for extracting material and energy from ELTs. This review outlines the cutting-edge thermochemical techniques for recycling tyres, encompassing gasification, pyrolysis, and incineration. Additionally, it delves into the primary by-products, including oil, gas, and char. The advantages and disadvantages of each process are discussed in terms of energy efficiency, product yield, and environmental impact. The optimal reaction conditions for each product yield and quality are identified and described. The correlation between process parameters and product composition, yield and quality is clarified. Products after further processing are illustrated with specific examples. Future research directions such as upgrade of char product using low-temperature partial-oxidation process are given. This review is novel in its comprehensive synthesis of the latest advancements in thermochemical techniques for recycling ELTs, highlighting recent innovations in gasification, pyrolysis, and incineration methods. It is also a timely review due to the urgent need for sustainable waste management solutions amidst growing environmental concerns and stringent regulations on tyre disposal.
Graphical Abstract
Impact of internal wave drag on Arctic sea ice
Authors: Flocco Daniela , Feltham Daniel , Schroeder David , Aksenov Yevgeny , Siahaan Antony , Tsamados Michel 
Published: October 2024

Abstract
A parameterization of the impact of internal waves on momentum transfer at the sea-ice–ocean interface based on previous work by McPhee has been implemented in a sea-ice model for the first time. The ice–ocean drag from internal waves is relevant for shallow mixed layer depth and the presence of a density jump at the pycnocline and is also a function of the strength of the stratification beneath the ocean mixed layer and geometry of the ice interface. We present results from a coupled sea-ice–ocean model where the parameterization of internal wave drag has been implemented. We conducted simulations spanning the years from 2000 to 2017. We find a deceleration of ice drift by 5–8% in both winter and summer, but with significant spatial and temporal variation reaching seasonal average values of ~10%. The spatial variation of ice transport leads to local impacts on deformed ice of magnitude ~0.05 m (2–5%), and reductions in ocean-to-ice heat fluxes of ~1 W m−2, and a decrease in bottom melt of ~0.02–0.04 cm d−1. There is an increase of up to 15% in thickness and ice concentration in the Canadian Arctic and a 10% overall impact on the total sea-ice volume.
Comparing heterogeneity of sea-ice models with viscous-plastic and Maxwell elasto-brittle rheology
Authors: Bourgett Mirjam , Losch Martin , Plante Mathieu 
Published: October 2024

Abstract
Classical sea-ice models in climate model resolution do not resolve the small-scale physics of sea ice. New methods to address this problem include modifications to established viscous-plastic (VP) rheology models, sub-gridscale parameterizations or new rheologies such as the Maxwell elasto-brittle (MEB) rheology. Here, we investigate differences in gridscale dynamics simulated by the VP and MEB models, their dependency on tunable model parameters and their response to added stochastic perturbations of material parameters in a new implementation in the Massachusetts Institute of Technology general circulation model. Idealized simulations are used to demonstrate that material parameters can be tuned so that both VP and MEB rheologies lead to similar cohesive stress states, arching behaviour and heterogeneity in the deformation fields. As expected, simulations with MEB rheology generally show more heterogeneity than the VP model as measured by the number of simulated linear kinematic features (LKFs). For both rheologies, the cohesion determines the emergence of LKFs. Introducing gridscale heterogeneity by random model parameter perturbation, however, leads to a larger increase of LKF numbers in the VP simulations than in the MEB simulations and similar heterogeneity between VP and MEB models.
Why aren't we teaching writing?: The advantages of early explicit writing instruction in linguistics
Authors: Doner Julianne , Sullivan Lisa , Melara Emilia , Yawney Heather 
Published: October 2024

AbstractLinguistics faculty are sometimes reluctant to provide explicit writing instruction in their courses. One major point of hesitancy is that there is not enough time to “add” writing to the curriculum. We argue, in contrast, that spending strategic time on writing reinforces and enriches the linguistics curriculum, rather than detracting from it. When students apply linguistics to the real world through relevant writing assignments, linguistics becomes more meaningful, which increases student engagement and improves the perception of linguistics. Explicit writing instruction is beneficial for all students, but especially marginalized students. Teaching students how to write also provides them with transferable skills that they can take with them to their future careers.