bluuebunny/crossref_metadata_2025_split huggingface dataset:
Communicating about Mental Illness and Violence: Balancing Stigma and Increased Support for Services
Authors: McGinty Emma E. , Goldman Howard H. , Pescosolido Bernice A. , Barry Colleen L. 
Published: March 2018

AbstractIn the ongoing national policy debate about how to best address serious mental illness (SMI), a major controversy among mental health advocates is whether drawing public attention to an apparent link between SMI and violence, shown to elevate stigma, is the optimal strategy for increasing public support for investing in mental health services or whether nonstigmatizing messages can be equally effective. We conducted a randomized experiment to examine this question. Participants in a nationally representative online panel (N = 1,326) were randomized to a control arm or to read one of three brief narratives about SMI emphasizing violence, systemic barriers to treatment, or successful treatment and recovery. Narratives, or stories about individuals, are a common communication strategy used by policy makers, advocates, and the news media. Study results showed that narratives emphasizing violence or barriers to treatment were equally effective in increasing the public's willingness to pay additional taxes to improve the mental health system (55 percent and 52 percent, vs. 42 percent in the control arm). Only the narrative emphasizing the link between SMI and violence increased stigma. For mental health advocates dedicated to improving the public mental health system, these findings offer an alternative to stigmatizing messages linking mental illness and violence.
Plasma Metabolite Profiles in Response to Chronic Exercise
Authors: BRENNAN ANDREA M. , BENSON MARK , MORNINGSTAR JORDAN , HERZIG MATTHEW , ROBBINS JEREMY , GERSZTEN ROBERT E. , ROSS ROBERT 
Published: March 2018

ABSTRACT

Purpose
High-throughput profiling of metabolic status (metabolomics) allows for the assessment of small-molecule metabolites that may participate in exercise-induced biochemical pathways and corresponding cardiometabolic risk modification. We sought to describe the changes in a diverse set of plasma metabolite profiles in patients undergoing chronic exercise training and assess the relationship between metabolites and cardiometabolic response to exercise.

Methods
A secondary analysis was performed in 216 middle-age abdominally obese men and women (mean ± SD, 52.4 ± 8.0 yr) randomized into one of four groups varying in exercise amount and intensity for 6-month duration: high amount high intensity, high amount low intensity, low amount low intensity, and control. One hundred forty-seven metabolites were profiled by liquid chromatography-tandem mass spectrometry.

Results
No significant differences in metabolite changes between specific exercise groups were observed; therefore, subsequent analyses were collapsed across exercise groups. There were no significant differences in metabolite changes between the exercise and control groups after 24 wk at a Bonferroni-adjusted statistical significance (P < 3.0 × 10−4). Seven metabolites changed in the exercise group compared with the control group at P < 0.05. Changes in several metabolites from distinct metabolic pathways were associated with change in cardiometabolic risk traits, and three baseline metabolite levels predicted changes in cardiometabolic risk traits.

Conclusions
Metabolomic profiling revealed no significant plasma metabolite changes between exercise and control after 24 wk at Bonferroni significance. However, we identified circulating biomarkers that were predictive or reflective of improvements in cardiometabolic traits in the exercise group.
Phylogeny of Zehneria (Cucurbitaceae) with special focus on Asia
Authors: Dwivedi Mayank D. , Barfield Siobhan , Pandey Arun K. , Schaefer Hanno 
Published: March 2018

AbstractZehneria is a genus of small creepers and climbers from the Old–World Tropics and Subtropics. In its broadest circumscription, it comprises up to 94 species and its centre of diversity is Southeast Asia. Zehneria has been split into several smaller genera but this remained controversial mainly due to morphological plasticity of the species groups and lack of comprehensive molecular data. Here, we use one nuclear DNA (ITS1–5.8S–ITS2) and three plastid DNA regions (trnL–trnF, rpl20–rps12, matK) sequenced for about half of the species in Zehneria and its segregate genera Anangia, Neoachmandra, and Pilogyne to test the monophyly of the genus and analyse the evolutionary history of the group. We find that Zehneria s.l. is monophyletic and splitting is not supported by molecular, morphological or biogeographical evidence. Within Zehneria, we recover two strongly supported clades, one consisting mainly of species placed in Pilogyne, the other including Anangia, Neoachmandra and the type of Zehneria. Both clades comprise African, Asian, and Australian/Pacific Island species, which is evidence for high dispersal capacity in this young bird–dispersed group. For India, we accept the five species Z. bodinieri, Z. hookeriana, Z. maysorensis, Z. odorata, and Z. thwaitesii. For Myanmar, we increase the number of known species from four to eight, including three still unnamed species. The diversity hotspots for the genus, however, remain Indonesia and Thailand with together 25 species.
ENTREVISTA COM O PROFESSOR DOUTOR JAMES GREEN, REALIZADA NO DIA 18 DE MAIO DE 2017, NA RESIDÊNCIA DA PROFESSORA DOUTORA LÚCIA VELLOSO MAURICIO, NA ZONA SUL DO RIO DE JANEIRO
Authors: Green James , Sepulveda Denize , Veloso Lúcia 
Published: March 2018

ENTREVISTA COM O PROFESSOR DOUTOR JAMES GREEN, REALIZADA NO DIA 18 DE MAIO DE 2017, NA RESIDÊNCIA DA PROFESSORA DOUTORA LÚCIA VELLOSO MAURICIO, NA ZONA SUL DO RIO DE JANEIRO
A cost-effectiveness analysis of a hydration response technology dressing in the treatment of venous leg ulcers in the UK
Authors: Walzer Stefan , Dröschel Daniel , Vollmer Lutz , Atkin Leanne , Ousey Karen 
Published: March 2018

Objective:Venous leg ulcers (VLUs) cause significant pain and suffering for patients. Additionally, they place considerable financial and service burden on the National Health Service (NHS). A large proportion of VLUs do not heal within the standard time frame of 16–24 weeks, resulting in static wounds which commonly have issues with increasing exudate production. As the NHS continues to face times of austerity, services need to find solutions to be able to reduce costs and release nursing time while maintaining standards of care. Cutimed Sorbion Sachet S, a hydration response technology dressing (HRTD), is a treatment option for the management of patients with a VLU. The objective of this study was to provide an update of the health economic analysis of HRTD in comparison with relevant comparators in the UK with current cost data.Method:HRTD was compared against four different dressings, Zetuvit Plus (a super absorbent polymer dressing SAP), DryMax extra (a superabsorbent dressing, SADM), KerraMax Care (superabsorbent dressing, SAKM) and Eclypse (superabsorbent dressing, SAE) from a cost-effectiveness perspective. Clinical data were derived from literature and expert opinion. Cost input was utilised based on publicly available data and literature. The average patient in the model is assumed to be 65 years with a diagnosed VLU. It is assumed that patients in the different treatment arms have the same background mortality, hence the endpoint mortality is not included in the model. The analysis is based on a deterministic Markov model derived from Harding et al. with weekly cycles. The following assumptions are made: first, all patients start in a static health state with a non-healed but non-progressing VLU. It is assumed in the model that patients wounds can transition to a deteriorating state or one where a wound is improving or could progress. Additionally, VLUs could be healed from a progressed wound (i.e. improved wound), or they could develop into a severe wound with complications (infections) to be treated in hospitals. The time frame for the analysis was fixed for one year and no re-occurence after healing was assumed to happen.Results:The cost-effectiveness analysis demonstrates health economic dominance of HRDT being more effective and cost-saving against all analysed comparators. When using literature-based input values, the incrementally higher healing rates for HRDT are 11.04 months (versus SAP), 29.04 months (versus SADM), 1.68 months (versus SAKM) and 11.04 months (versus SAE). Cost savings per patient were £37.60 versus SAP, £171.68 versus SADM, £3.13 versus SAKM and £43.63 versus SAE.Conclusion:Clinical benefits and cost savings increase when real-life practice assumptions, based on expert opinion, are included. Based on the underlying health economic model, HRDT is more effective and less costly than other comparative products in VLUs in the UK.
Representativeness of the IAGOS airborne measurements in the lower troposphere
Authors: Petetin H. , Jeoffrion M. , Sauvage B. , Athier G. , Blot R. , Boulanger D. , Clark H. , Cousin J.-M. , Gheusi F. , Nedelec P. , Steinbacher M. , Thouret V. 
Published: March 2018

In the framework of the In Service Aircraft for Global Observing System (IAGOS) program, airborne in-situ O3 and CO measurements are performed routinely using in-service aircraft, providing vertical profiles from the surface to about 10–12 km. Due to the specificity of IAGOS measurements (measurements around busy international airports), uncertainties exist on their representativeness in the lower troposphere as they may be impacted by emissions related to airport activities and/or other aircraft. In this study, we thus investigate how the IAGOS measurements in the lower troposphere compare with nearby surface stations (from the local Air Quality monitoring network (AQN)) and more distant regional surface stations (from the Global Atmospheric Watch (GAW) network). The study focuses on Frankfurt but some results at other European airports (Vienna, Paris) are also discussed.
Results indicate that the IAGOS observations close to the surface do not appear to be strongly impacted by local emissions related to airport activities. In terms of mixing ratio distribution, seasonal variations and trends, the CO and O3 mixing ratios measured by IAGOS in the first few hundred metres above the surface have similar characteristics to the mixing ratios measured at surrounding urban background stations. Higher in altitude, both the difference with data from the local AQN and the consistency with the GAW regional stations are higher, which indicates a larger representativeness of the IAGOS data. Despite few quantitative differences with Frankfurt, consistent results are obtained in the two other cities Vienna and Paris.
Based on 11 years of data (2002–2012), this study thus demonstrates that IAGOS observations in the lowest troposphere can be used as a complement to surface stations to study the air quality in/around the agglomeration, providing important information on the vertical distribution of pollution.
Does the uptake of wagering inducements predict impulse betting on sport?
Authors: Hing Nerilee , Russell Alex M. T. , Li En , Vitartas Peter 
Published: March 2018

Background and aims
Marketing inducements for addictive products, such as wagering, can prompt impulse purchasing by triggering consumption reminders, urges, and cravings. Wagering inducements incentivize betting by providing bonus bets, money-back guarantees, deposits into betting accounts, and discounts. Their promotion during sporting events, push marketing efforts directed at consumers, and ease of uptake at the point-of-sale, may trigger betting on impulse. This study examined whether the uptake of wagering inducements predicted impulse betting on sport.

Methods
Australian sports bettors (N = 1,813) completed an online survey measuring their proportion of planned bets, impulse bets before match commencement, and impulse bets during play; frequency of using wagering inducements; and several psychological, behavioral, and demographic variables.

Results
More frequent users of wagering inducements had a greater tendency to place impulse in-play bets, which were also predicted by problem gambling, higher buying impulsiveness, higher frequency of watching sports, younger age, and higher educational status. Sports bettors with a greater tendency to place impulse bets before match commencement also tended to have higher buying impulsiveness and to be younger, but they used inducements less frequently, and tended to be female, less-educated and non-problem, moderate risk, or problem gamblers.

Discussion and conclusions
Uptake of wagering inducements appeared to be particularly effective in stimulating impulse in-play betting among problem gamblers and frequent sports viewers. These results suggest that a more cautious approach to the regulation of both in-play bets and wagering inducements may be required to better protect young adults from gambling problems and harm.
The Hearing Voices Movement as Postmodern Religion-Making
Authors: Powell Adam 
Published: March 2018

Over the past 40 or 50 years, scholars of religion have frequently attempted to use the tools of social science to analyse, describe, and explain the relevance and persistence of religion in the modern world. With the bold predictions of the secularization thesis as their stimuli, many sociologists and anthropologists preferred to focus on the underexplored, marginalised, or otherwise unexpected expressions of religion within those ostensibly secularising contexts. Such studies have led to an abundance of theories and accompanying terms: ‘implicit religion’, ‘vernacular religion’, ‘vicarious religion’, ‘lived religion’, ‘popular religion’, and ‘folk religion’. Without choosing any one of these, but owing much to their shared – arguably postmodern – themes of commonplace sacrality and personal empowerment, this paper seeks to explore the possibility of the Hearing Voices Movement (HVM) as an example of religion-making. HVM is a growing force of ‘voice-hearers’ from at least 28 countries who have formed user-led networks for activism and mental health recovery. More importantly, it is argued that HVM blends meaning-making, postmodern notions of identity in relation to power structures, and ritual embodiment, resulting in a striking example of sociologist Hans Mol’s notion of religion as a sacralizing process.
Open Access: Attribution—Non Commercial—NoDerivs / CC BY-NC-ND
A First-in-Human Phase I Study of OPB-111077, a Small-Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers
Authors: Tolcher Anthony , Flaherty Keith , Shapiro Geoffrey I. , Berlin Jordan , Witzig Thomas , Habermann Thomas , Bullock Andrea , Rock Edwin , Elekes Agnes , Lin Chester , Kostic Dusan , Ohi Naoto , Rasco Drew , Papadopoulos Kyriakos P. , Patnaik Amita , Smith Lon , Cote Gregory M. 
Published: March 2018

Abstract

Lessons Learned
OPB-111077 is a novel inhibitor of STAT3 and mitochondrial oxidative phosphorylation that exhibited promising anticancer activity in preclinical models. In this first-in-human phase I study of OPB-111077 in unselected advanced cancers, treatment-emergent adverse events, most frequently nausea, fatigue, and vomiting, were generally mild to moderate in intensity and could be medically managed. Overall, only modest clinical activity was observed after OPB-111077 given as monotherapy. Notable antitumor activity was seen in a subject with diffuse large B-cell lymphoma.

Background
OPB-111077 is a novel inhibitor of STAT3 and mitochondrial oxidative phosphorylation with promising anticancer activity in preclinical models.

Methods
Open-label, phase I trial of OPB-111077 in advanced cancers with no available therapy of documented benefit. Initial dose escalation in unselected subjects was followed by dose expansion. Patients received oral OPB-111077 daily in 28-day cycles until loss of clinical benefit.

Results
Eighteen subjects enrolled in dose escalation, and 127 in dose expansion. Dose-limiting toxicities were observed at 300 mg and 400 mg QD; maximum tolerated dose was defined as 250 mg QD. Frequently reported treatment-emergent adverse events (TEAEs) included nausea, fatigue, and vomiting. TEAEs were generally mild to moderate and could be medically managed. OPB-111077 reached micromolar drug concentrations, had an elimination half-life of approximately 1 day, and reached steady-state by day 8. A durable partial response was observed in one subject with diffuse large B-cell lymphoma. Seven subjects with diverse tumor types had stable disease or minor responses for at least eight treatment cycles (224 days).

Conclusion
OPB-111077 is generally well tolerated, and its pharmacokinetic profile is sufficient for further clinical development. Notable clinical activity was observed in a subject with diffuse large B-cell lymphoma. Overall, modest efficacy was observed against unselected tumors.
Recepcja twórczości Ricardy Huch w Niemczech - wokół jubileuszu 150. rocznicy urodzin poetki w 2014 roku
Authors: JELITTO-PIECHULIK Gabriela 
Published: March 2018

Niniejszy artykuł przedstawia stan badań nad recepcją twórczości niemieckiej pisarki Ricardy Huch w Niemczech wokół jubileuszu 150. rocznicy jej urodzin w 2014 roku. Renesans recepcji życia i twórczości Huch w roku jubileuszowym można rozpatrywać w następujących kategoriach: konferencje i sympozja, odczyty, wystawy i wizualizacje, oficjalne uroczystości w Turyngii, utworzenie strony internetowej poświęconej życiu, twórczo-ści i recepcji dzieła autorki oraz publikacje będące zwieńczeniem naukowym roku jubileuszowego. Inicjatywy podjęte przez naukowców, społeczników i lokalne instytucje samorządowe skierowane do różnych grup społecznych w Niemczech pokazały, że twórczość pisarska Ricardy Huch może zainspirować współczesnego niemieckiego czytelnika. Kolejnego renesansu poczytności dzieł można spodziewać się w roku 2017, w którym przypada 70. rocznica śmierci pisarki oraz 500. rocznica reformacji, której Huch poświęciła rozprawy religijno-światopoglądowe nawiązujące do postaci Marcina Lutra.
EVALUASI HUBUNGAN DOSIS RADIASI TERHADAP KERUSAKAN DNA SEL LIMFOSIT DENGAN MENGGUNAKAN TES COMET
Authors: Yusuf Darlina , Rahardjo Tur , Syaifudin Mukh 
Published: March 2018

EVALUASI HUBUNGAN DOSIS RADIASI TERHADAP KERUSAKAN DNA SEL LIMFOSIT DENGAN MENGGUNAKAN TES COMET. Kerusakan asam nukleat (DNA) akibat radiasi atau faktor lain dapat mengarah ke efek yang lebih parah seperti sel kanker. Oleh karena itu diperlukan suatu metode deteksi untuk mengetahui besarnya kerusakan tersebut antara lain dengan metode uji komet yang sederhana. Tujuan penelitian ini adalah mengkaji efek radiasi pada sel limfosit akibat radiasi melalui teknik uji komet. Spesimen darah diiradiasi dosis gamma 2-8 Gy kemudian diisolasi limfositnya dengan histopaque. Isolat limfosit diproses uji komet pada slide dalam kondisi alkali dan hasil pencitraan dianalisis dengan software khusus. Hasil menunjukkan bahwa terdapat korelasi positif parameter komet dengan dosis radiasi, semakin besar dosis paparan semakin besar kerusakan DNA. Diantara parameter uji komet, tail DNA memberikan korelasi yang terbaik dengan dosis radiasi. Disimpulkan bahwa uji komet sangat baik digunakan untuk mengetahui kerusakan DNA akibat radiasi.
ANÁLISE DO TAMANHO DOS FILMES LÍQUIDOS FORMADOS NO JATO DE PULVERIZAÇÃO DE PONTAS DE JATO PLANO E SUA INFLUÊNCIA NO DIÂMETRO MEDIANO VOLUMÉTRICO
Authors: Jesus Marcella Guerreiro , Antuniassi Ulisses Rocha , Mota Alisson A. B. , Moreira Caio A. F. , Carvalho Fernando Kassis 
Published: March 2018

Muitas são as variáveis que interferem no espectro das gotas formadas em uma pulverização agrícola, a padronização do tamanho de gotas inteferem de forma significativa no resultado final de uma aplicação. O objetivo do trabalho foi analisar o comprimento dos filmes líquidos obtidos no momento da saída da calda na ponta de pulverização de jato plano XR 11002 e sua influência no tamanho das gotas produzidas. Os tratamentos foram constituídos de misturas contendo fungicidas e adjuvantes, as quais foram pulverizadas em uma pressão de 300 kPa. O diâmetro mediano volumétrico (DMV) foi determinado em analisador de gotas por difração de laser e os comprimentos dos filmes líquidos gerados nos jatos de pulverização foram determinados por videografia e análise digital das imagens. A correlação entre os dados de DMV e o comprimento do filme líquido foi analisada através do coeficiente de correlação de Pearson. Os resultados mostraram coeficientes de correlação significativos entre o comprimento do filme líquido e o DMV na pulverização formada pela pontas XR 11002. A substituição de óleos por adjuvantes não oleosos resultou em redução do DMV gerado na aplicação de fungicidas.PALAVRAS-CHAVE: espectro de gotas, pontas de pulverização, defensivos agrícolas. ANALYSIS OF THE SIZE OF LIQUID SHEET FORMED IN FLAT FAN NOZZLES AND ITS INFLUENCE ON THE VOLUME MEDIAN DIAMETERABSTRACT: There are many variables that interfere with the spectrum of droplets formed in an agricultural spray, the droplet size has a significantly interferes with the final result of an application. The objective of this work was to analyze the length of the liquid films obtained at the moment the solution exit the XR 11002 flat jet spray tip and its influence on the size of the droplets produced. The treatments were composed of mixtures containing fungicides and adjuvants, which were sprayed at a pressure of 300 kPa. The volumetric median diameter (DMV) was determined in a laser diffraction drop analyzer and the lengths of the liquid films generated in the spray nozzles were determined by videography and digital analysis of the images. The correlation between the DMV data and the liquid film length was analyzed using the Pearson correlation coefficient. The results showed significant interference with the correlation coefficients between the liquid film length and the DMV in the spray formed by the XR 11002 nozzles. The substitution of oils with non-oily adjuvants resulted in reduction of the DMV generated in the application of fungicides.KEYWORDS: Droplet spectra, nozzles, pesticides.