bluuebunny/crossref_metadata_2025_split huggingface dataset:
Panhypopituitarism Without GH Replacement: About Insulin Sensitivity, CRP Levels, and Metabolic Syndrome
Authors: Castillo Alejandro , Zantut-Wittmann Denise , Neto Arnaldo , Jales Rodrigo , Garmes Heraldo 
Published: September 2018

AbstractA complete deficiency of anterior pituitary hormones from several etiologies characterizes Panhypopituitarism (PH). Despite advances in treatment, patients with PH maintain high rates of morbidity and mortality, a reason to investigate some insulin sensitivity, metabolic and inflammatory parameters that could be related to the increase of these indicators. This was a cross-sectional study comprising 41 PH patients under hormonal replacement, except for growth hormone, and 37 individuals in a control group (CG) with similar age, gender and body mass index (BMI). We assessed clinical data as age, sex, BMI, waist circumference, waist/hip ratio (WHR), history of hypertension, diabetes mellitus and dyslipidemia as well as fasting glycaemia, insulin, HOMA-IR, HbA1c, high-sensitivity CRP (hs-CRP), and lipid profile. PH patients presents lower values of glycaemia, insulin, HOMA-IR (0.88 vs 2.1) and WHR, but higher levels of hs-CRP (0.38 vs 0.16mg/dl) when compared with the CG. Although the occurrence of dyslipidemia was higher in patients with PH, the frequency of metabolic syndrome was similar between the groups. In multivariate linear regression analysis, the PH group independently predicted lower HOMA-IR and WHR values. In conclusion, this study demonstrated that patients with PH without GH replacement have lower HOMA-IR and WHR values and higher levels of hs-CRP than a CG paired by age, gender and BMI. The diagnosis of dyslipidemia was more frequent in patients with PH, but the occurrence of MS was similar to CG. Further studies are needed to confirm our findings and to better understand the metabolic characteristics of patients with PH.
Maternal Obesity Affects Cardiac Remodeling and Recovery in Women with Peripartum Cardiomyopathy
Authors: Davis Esa , Ewald Gregory , Givertz Michael , Rajagopalan Navin , Cooper Leslie , Briller Joan , Felker G. , Bozkurt Biykem , Drazner Mark , Hanley-Yanez Karen , Halder Indrani , McTiernan Charles , McNamara Dennis ,   on behalf of the IPAC Investigators
Published: September 2018

Objective To examine the association between maternal obesity on left ventricular (LV) size and recovery in women with peripartum cardiomyopathy (PPCM).
Study Design This was a prospective analysis of 100 women enrolled within 13 weeks of PPCM diagnosis and followed for a year in the Investigation of Pregnancy Associated Cardiomyopathy study. Adiposity was defined by standard body mass index (BMI) definitions for under/normal weight, overweight, and obesity. Demographic, clinical, and biomarker variables were compared across weight categories.
Outcomes LV end-diastolic diameter (LVEDD) and ejection fraction were measured at entry, 6, and 12 months postpartum. Multivariable regression models examined the relationship between adiposity, LV size, and leptin levels with cardiac recovery at 6 and 12 months postpartum.
Results Obese and nonobese women had similar LV dysfunction at entry. Obese women had greater LV size and less LV recovery at 6 and 12 months postpartum. BMI was positively associated with leptin and ventricular diameter. Greater BMI at entry remained associated with less ventricular recovery at 6 months (p = 0.02) in adjusted race-stratified models. LVEDD at entry predicted lower ejection fraction at 6 months (p < 0.001) and similarly at 12 months.
Conclusion Obese women with PPCM had greater cardiac remodeling, higher leptin levels, and diminished cardiac recovery.
Metformin Regulates the Expression of SK2 and SK3 in the Atria of Rats With Type 2 Diabetes Mellitus Through the NOX4/p38MAPK Signaling Pathway
Authors: Liu Changhe , Hua Na , Fu Xi , Pan Yilong , Li Bin , Li Xiaodong 
Published: September 2018

Abstract:
We previously found that metformin regulates the ion current conducted by the small conductance calcium-activated potassium channels (SK channels) in the atria of rats with type 2 diabetes mellitus (T2DM) as well as the mRNA and protein expression of the SK2 and SK3 subtypes of SK channels. In this study, we hypothesized that the nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4)/p38 mitogen-activated protein kinase (p38MAPK) signaling pathway was involved in the metformin-mediated regulation of SK2 and SK3 expression in the atria of rats with T2DM. We randomly divided Wistar rats into the control group, the untreated T2DM group, the metformin-treated group, the group receiving subcutaneous injections of the nicotinamide adenine dinucleotide phosphate oxidase (NOX) inhibitor diphenyleneiodonium (DPI), and the group receiving tail vein injections of the p38MAPK agonist anisomycin. Real-time polymerase chain reaction, Western blot, and immunohistochemistry were applied to examine the expression levels of SK2, SK3, NOX4, and phospho-p38MAPK (p-p38MAPK) mRNAs and proteins in the atrial tissue of relevant groups. We observed that the expression levels of NOX4 mRNA and protein and p-p38MAPK protein were significantly elevated in the atria of rats with T2DM compared with the control group. In addition, SK2 protein expression was reduced, whereas SK3 protein expression was increased. The 8-week treatment with metformin markedly reduced the expression levels of NOX4 mRNA and protein and p-p38MAPK protein, upregulated the SK2 expression, and downregulated the SK3 expression. Tail vein injection with anisomycin significantly increased the p-p38MAPK expression while further inhibiting the expression of SK2 and enhancing the expression of SK3. Subcutaneous injection with DPI considerably inhibited the expression of NOX4, further enhanced the expression of SK2 and suppressed the expression of SK3. In addition, subcutaneous injection with DPI significantly suppressed the phosphorylation of p38MAPK. In conclusion, the NOX4/p38MAPK signaling pathway mediates the downregulation of SK2 and the upregulation of SK3 in the atria of rats with T2DM. Long-term metformin treatment upregulates SK2 protein expression and downregulates SK3 protein expression by inhibiting the NOX4/p38MAPK signaling pathway.
Inter-relationship between diet, lifestyle habits, gut microflora, and the equol-producer phenotype: baseline findings from a placebo-controlled intervention trial
Authors: Yoshikata Remi , Myint Khin Z. , Ohta Hiroaki , Ishigaki Yoko 
Published: September 2018

Abstract

Objective:
Equol is an active metabolite of isoflavones produced by gut microbiota. It is beneficial to health; however, equol-producing ability varies greatly among individuals. These variations depend on the host's gut microbiota and lifestyle habits including diet. We investigated the relationship between the gut microbiota, lifestyle habits including diet, and equol-producing ability in postmenopausal Japanese women.

Methods:
We studied 58 postmenopausal Japanese women aged 48 to 69 years who visited the Sendai Medical Center in January, 2018. Self-administered questionnaires assessed their recent and remote food intake histories and lifestyle habits. Fecal microbiome analysis was performed using a next-generation sequencer. Urinary equol was measured using an immunochromatographic strip test. Women with urinary equol concentration >1.0 μM were defined as equol producers.

Results:
Equol-producing bacteria were identified in 97% (56) of women; however, only 13 (22%) were equol producers. Equol producers showed significantly higher microflora diversity (P = 0.002), and significantly different recent and remote food intake patterns compared with equol nonproducers. Higher consumption of foods such as meat, fish, soy, vegetables, and Japanese snacks positively affected microbial diversity and equol production, whereas a high intake of Ramen and smoking showed negative effects.

Conclusion:
Equol production might not depend on the quantity, but on the quality of equol-producing bacteria. High microbial diversity might enhance equol production. Increasing microbial diversity through healthy lifestyle habits and habitual consumption of a wide variety of foods might be useful to maintain a healthy gut environment for equol production.
Neuropathic pain and pain interference are linked to alpha-band slowing and reduced beta-band magnetoencephalography activity within the dynamic pain connectome in patients with multiple sclerosis
Authors: Kim Junseok A. , Bosma Rachael L. , Hemington Kasey S. , Rogachov Anton , Osborne Natalie R. , Cheng Joshua C. , Oh Jiwon , Crawley Adrian P. , Dunkley Ben T. , Davis Karen D. 
Published: September 2018

Abstract
Chronic pain is a common occurrence in multiple sclerosis (MS) that severely affects quality of life, but the underlying brain mechanisms related to these symptoms are unknown. Previous electroencephalography studies have demonstrated a role of alpha-band and beta-band power in pain processing. However, how and where these brain signals change in MS-related chronic pain is unknown. Here, we used resting state magnetoencephalography to examine regional spectral power in the dynamic pain connectome—including areas of the ascending nociceptive pathway, default mode network (DMN), and the salience network (SN)—in patients with chronic MS pain and in healthy controls. Each patient was assessed for pain, neuropathic pain (NP), and pain interference with activities of daily living. We found that patients with MS exhibited an increase of alpha-band power and a decrease of beta-band power, most prominently in the thalamus and the posterior insula of the ascending nociceptive pathway and in the right temporoparietal junction of the SN. In addition, patients with mixed-NP exhibited slowing of alpha peak power within the thalamus and the posterior insula, and in the posterior cingulate cortex of the DMN. Finally, pain interference scores in patients with mixed-NP were strongly correlated with alpha and beta peak power in the thalamus and posterior insula. These novel findings reveal brain mechanisms of MS-related pain in the ascending nociceptive pathway, SN, and DMN, and that these spectral abnormalities reflect the impact of pain on quality of life measures.
Noninvasive Flap Preconditioning by Foam-Mediated External Suction Improves the Survival of Fasciocutaneous Axial-Pattern Flaps in a Type 2 Diabetic Murine Model
Authors: Rhodius Patrick , Haddad Anthony , Matsumine Hajime , Sakthivel Dharaniya , Ackermann Maximilian , Sinha Indranil , Orgill Dennis P. , Giatsidis Giorgio 
Published: September 2018

Background:
Advances in reconstructive surgery are leading to an increased number of flaps at risk for ischemic necrosis, because of either intrinsic (e.g., larger flap size) or extrinsic (e.g., diabetes) factors. Methods to preoperatively improve flap vascularity and limit postoperative ischemia are lacking. Noninvasive suction, using either a macrodeformational silicone cup interface (external volume expansion) or a microdeformational polyurethane foam interface (foam-mediated external volume expansion), has been shown to induce angiogenesis in tissues. The authors investigated whether the preoperative use of external volume expansion/foam-mediated external volume expansion improves flap survival in an obesity-induced diabetic animal model.

Methods:
Db/Db mice underwent either mechanical stimulation with suction for 5 days using either external volume expansion or foam-mediated external volume expansion, or received no stimulation (n = 8 per group). Five days after the last stimulation, a critical-size, axial-pattern, fasciocutaneous flap was raised in all animals. Postoperatively, flap survival was monitored with digital imaging for 10 days. After this period, flaps were harvested to assess tissue survival, angiogenesis, and inflammation, using histology and polymerase chain reaction.

Results:
Foam-mediated external volume expansion preconditioning significantly increased the viable flap area (28 percent), viable flap volume (27 percent), and flap capillary density (36 percent) in comparison to controls; vascular endothelial growth factor was also up-regulated (>300 percent). In contrast, external volume expansion resulted in a severe inflammatory response and increased flap necrosis.

Conclusions:
Foam-mediated external volume expansion improves flap survival in obese diabetic mice. This procedure may allow for improved clinical rates of flap survival in high-risk patients.
HPCI: A Perl module for writing cluster-portable bioinformatics pipelines
Authors: Macdonald John M , Lalansingh Christopher M , Cooper Christopher I , Yang Anqi , Lam Felix , Boutros Paul C 
Published: September 2018

AbstractBackgroundMost biocomputing pipelines are run on clusters of computers. Each type of cluster has its own API (application programming interface). That API defines how a program that is to run on the cluster must request the submission, content and monitoring of jobs to be run on the cluster. Sometimes, it is desirable to run the same pipeline on different types of cluster. This can happen in situations including when:different labs are collaborating, but they do not use the same type of clustera pipeline is released to other labs as open source or commercial softwarea lab has access to multiple types of cluster, and wants to choose between them for scaling, cost or other purposesa lab is migrating their infrastructure from one cluster type to anotherduring testing or travelling, it is often desired to run on a single computerHowever, since each type of cluster has its own API, code that runs jobs on one type of cluster needs to be re-written if it is desired to run that application on a different type of cluster. To resolve this problem, we created a software module to generalize the submission of pipelines across computing environments, including local compute, clouds and clusters.ResultsHPCI (High Performance Computing Interface) is a Perl module that provides the interface to a standardized generic cluster.When the HPCI module is used, it accepts a parameter to specify the cluster type. The HPCI module uses this to load a driver HPCD∷<cluster>. This is used to translate the abstract HPCI interface to the specific software interface.Simply by changing the cluster parameter, the same pipeline can be run on a different type of cluster with no other changes.ConclusionThe HPCI module assists in writing Perl programs that can be run in different lab environments, with different site configuration requirements and different types of hardware clusters. Rather than having to re-write portions of the program, it is only necessary to change a configuration file.Using HPCI, an application can manage collections of jobs to be runs, specify ordering dependencies, detect success or failure of jobs run and allow automatic retry of failed jobs (allowing for the possibility of a changed configuration such as when the original attempt specified an inadequate memory allotment).
The state and evolution of Gold open access: a country and discipline level analysis
Authors: Wang Xianwen , Cui Yunxue , Xu Shenmeng , Hu Zhigang 
Published: September 2018

Purpose
The purpose of this paper is to investigate the evolution of Gold open access (OA) rates in different countries and disciplines, as well as explore the influencing factors.

Design/methodology/approach
In this study, employing the OA filter option of Web of Science (WoS), the authors perform a large-scale evaluation of the OA state of countries and disciplines from 1990 to 2016. Particularly, the authors consider not only the absolute number of Gold OA literature but also the ratio of them among all literature.

Findings
Currently, one-quarter of the WoS articles is Gold OA articles. Brazil is the most active country in OA publishing, while Russia, India and China have the lowest OA ratios. The OA percentage of Brazil has been decreasing dramatically in recent years, while the OA percentages of China, UK and the Netherlands have been increasing. There also exist huge differences of OA percentages across different subject categories. The percentages of OA articles in biology, life, and health-related areas are high, while those in physics and chemistry-related subject categories are very low.

Originality/value
With the availability of large-scale data from WoS, this study conducts a comprehensive evaluation of the Gold OA state of major countries for the first time. The variation of OA percentages is considered in light of the research profiles. OA policies in different countries and funding organizations also have an influence on the OA development.
High or low season?
Authors: Ma Judy , Huang Dongling , Markovitch Dmitri G. , Ratchford Brian 
Published: September 2018

Purpose
This paper aims to investigate the moderating impacts of seasonality on the effectiveness of new product commercialization strategies in short-lifecycle markets. The authors contextualize their theory in the vast and culturally significant entertainment industry sector and contrast the effects between independent films and big budget movies.

Design/methodology/approach
This study uses an econometric modeling approach.

Findings
This study finds that unlike new films by well-resourced studios, which must launch in a high season for best performance, independents can generate more revenue in low seasons under certain conditions. The study shows how seasonality moderates the effectiveness of new films’ commercialization strategies and how new product outcomes are different for small independent products than for big-budget productions with regards to distribution duration, advertising expenditure and product characteristics.

Research limitations/implications
This research extends the literature on launch timing, which examines various strategic tradeoffs. In contrast with the few extant studies whose concern is sensitizing to the effects of seasonality (Siqueiraet al., 2016), this research treats seasonality as an exploitable opportunity that can be strategically factored into business planning for small producers. Accordingly, this is the first study to theoretically and empirically investigate the moderating relationship between seasonality, marketing decisions, product characteristics and performance.

Practical implications
To achieve useful specificity, the study constructs its discussion around the highly seasonal entertainment industry sector. The study shows that seasonality moderates the effectiveness of new films’ commercialization decisions and that the strategic outcomes are different for small independent products than for major studio productions in particular.

Originality/value
In contrast with extant research whose concern is sensitizing to the effects of seasonality, our research treats seasonality as an exploitable opportunity that can be strategically factored into business planning. Accordingly, ours is the first study to theoretically and empirically investigate the moderating relationship between seasonality, marketing decisions, product characteristics and performance.
Fiscal sustainability challenges in the new normal of low oil prices
Authors: El Mahmah Assil , Kandil Magda 
Published: September 2018

PurposeGiven the persistence of low oil prices and the continued shrinking of government revenues, Gulf Cooperation Council (GCC) countries continue to adapt to the new normal of the oil price environment, with a focus on pressing ahead with subsidies’ reforms and measures to increase non-oil revenues, as well as accelerating debt issuance, which raise concerns about fiscal sustainability and the implications on macroeconomic stability.Design/methodology/approachThe purpose of this paper is to examine the sustainability of fiscal policy in GCC by exploring governments’ reaction to rising public debt accumulation via the estimation of a fiscal reaction function to higher debt. Subsequently, the paper compares the obtained results with other similar and non-similar groups, in terms of economic structures and oil dependency, to understand how some macroeconomic factors affect differently the fiscal policy responses, in a context of oil price shocks and high price volatility.FindingsThe results show that the coefficient of the lagged debt stock was significant and positive, which means that GCC are increasing the pace of reforms and the fiscal primary balance as they issue more debt to ensure a sustainable fiscal policy. The evidence is consistent with the theory that higher levels of debt warrant greater fiscal effort, but at lower debt levels, countries still have the space to increase spending without jeopardizing debt sustainability as long as they remain committed to fiscal reforms to increase the primary balance. The evidence supports the notion that the region’s public finances have improved in response to recent fiscal adjustments. However, national experiences differ considerably, especially given variation in the fiscal breakeven prices against the new normal of low oil prices. Moreover, the findings reveal that various measures of economic performance, as captured by economic growth, openness and the oil price, were also found to be important factors in explaining fiscal performance. The combined effects of low oil prices and high degree of openness warrant further efforts to reform the budget to increase the primary balance while safeguarding priority spending tomobilize non-energy growth and ensure debt sustainability in GCC.Originality/valueGiven recent experiences and the “low for long” oil price, policy priorities and reforms are necessary in oil-dependent economies, including GCC, to ensure macroeconomic sustainability. Sustaining the momentum of non-energy growth would reduce continued dependency of GCC economies on oil revenues and fiscal spending in the medium-term, creating a bigger scope for private sector participation in economic activity and increasing the prospects of further diversification away from long dependency on oil price volatility and their adverse implications on the fiscal budget and economic cycles.
Materialism, social stratification, and ethics: evidence from SME owners in China
Authors: Su Taoyong , Ji Junzhe , Huang Qingan , Chen Lei 
Published: September 2018

PurposeThe study of business ethics has seldom shed light on small- and medium-sized enterprises (SMEs) despite their theoretical and practical significance. Drawing from strain perspective, the purpose of this paper is to address this insufficiency and investigate SME owners’ ethical attitudes toward money-related deviances.Design/methodology/approachBased on a large sample of 741 Chinese SMEs, an OLS regression analysis was employed to test associated hypotheses. The robustness of results was additionally checked.FindingsThe results suggest that for stratification variables, education level is positively related to ethical attitudes, whereas household income level is surprisingly negatively associated with ethical attitudes; for materialism facets, success and happiness exert a negative impact on ethical attitudes as hypothesized, but centrality has no associated impact.Research limitations/implicationsThis study has examined both structural and motivational sources of personal strains on the ethical attitude of SME owners, while the characteristics of these strains could be explored in the future studies.Originality/valueThis study advances and complements the dominant behavior approach that emphasizes cognitive and other psychological processes in explaining individual ethical attitudes. It is also seemingly the first study to examine the influence of three materialism facets on entrepreneurial ethical attitudes.