bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uterus‐Mimetic Extracellular Microenvironment for Engineering Female Reproductive System
Authors: Cha Eunju , Choi Yi Sun , Lee Mi Jeong , Kim Minjun , Seo Seung Ju , Kwak Su Min , Park Sewon , Cho Seung‐Woo , Jin Yoonhee 
Published: November 2024

AbstractAddressing the complexities and challenges inherent in endometrial biology and regeneration, this study develops a uterus‐mimetic microenvironment to reconstitute the female reproductive system. Leveraging a decellularized uterus extracellular matrix (UEM), this approach supports the development and functions of endometrial organoids (EOs) more effectively than the current gold standard, Matrigel. Extensive proteomic analysis across eight different tissue‐derived matrices reveals that those closely mirroring the protein profile of UEM–especially those abundant in proteins specific to the female reproductive system–more effectively support EO growth. These proteins, particularly fibronectin, and decorin, are identified as key enhancers of EO development, with decorin notably amplifying Wnt7a gene expression, a pathway important for endometrial development. In vivo, UEM demonstrates remarkable efficacy in regenerative applications, notably enhancing epithelial regeneration and increasing pregnancy rates in an endometrium injury model. Moreover, the sophisticated in vitro modeling provided by UEM facilitates effective decidualization of endometrial stromal cells and structural superiority when co‐cultured with EOs, thus offering an enhanced platform for studying blastocyst implantation. Collectively, these findings demonstrate UEM's pivotal role in reconstituting the reproductive system, highlighting its effectiveness in producing organoids that are not only structurally and functionally robust but also therapeutically potent.
Stable White Afterglow Along the Blackbody Radiation Line Enabled by Assisted Partial Phosphorescence Resonance Energy Transfer
Authors: Wu Tongyue , Liao Peilong , Qi Weilin , Song Huaiyu , Li Hongpeng , Huang Jianbin , Yan Yun 
Published: November 2024

AbstractWhite afterglow is very appealing both in scenario‐specific luminescence and background‐free bio‐imaging, while it is challenging to obtain stable white afterglow due to the difficulty in matching the emission lifetimes of complementary colors. It is reported here that assisted partial phosphorescence resonance energy transfer (ap‐PRET) can be a very efficient way toward this goal. When a blue afterglow of energy donor with long lifetime is obtained in a polymeric network displaying phosphorescent clusterization‐triggered emission (CTE), the network assisted partial phosphorescence resonance energy transfer (ap‐PRET) between it and a yellow fluorescent acceptor would yields orange afterglow. Owing to the energy supply of the CTE network, the lifetime of the donors blue afterglow can be tuned close to that of the acceptors orange afterglow through ap‐PRET in a wide donor to accepter ratios, and emissions ranging from the cold to warm white afterglows can be obtained. Amazingly, these white afterglows are along the blackbody radiation line in the CIE plot, disclosing the powerful ability of ap‐PRET in generating desired white afterglows for applications in diversified luminescent scenarios.
Self‐Recoverable and NIR‐I to NIR‐II Tunable Broadband Mechanoluminescence of Cr3+‐Doped Antimonate Double Perovskites
Authors: Dou Chao , Liang Tianlong , Zhao Meng , Song Zhen , Ning Lixin , Peng Dengfeng , Liu Quanlin 
Published: November 2024

AbstractMechanoluminescence (ML), which generates an optical response to external mechanical stimuli, shows promise for high‐end stress sensing, flexible optoelectronic skin, dynamic mechanical visualization, and anti‐counterfeiting applications. Near‐infrared (NIR) light possesses the advantages of high tissue penetration capability and can be absorbed by certain organic molecules, thus NIR‐ML materials have potential applications in biomechanics imaging, nondestructive composition analysis, etc. However, their practical applications are limited by the emission wavelengths and bandwidths of the NIR‐ML materials. In this study, a series of double perovskites A2MSbO6:Cr3+ (A = Sr, Ba; and M = Ga, Sc) is reported with self‐recoverable NIR‐ML emissions. By modulating the composition, the ML emission coverage are tuned from NIR‐I to NIR‐II (700 nm to over 1200 nm), and adjusted the full width at half maximum of the emission to 163 nm. In addition, under ultrasonic stimulation, these A2MSbO6:Cr3+ ML materials emitted NIR light, with the NIR light from Sr2ScSbO6:Cr3+ penetrating 5 mm of beef tissue. This study expands the library of NIR‐ML light sources and the ML spectral range, thereby promoting new applications of NIR‐ML materials.
Facilitating Dielectric Elastomer Actuator Multilayer Fabrication and Performance Through Low‐Contact‐Resistance Hybrid Electrodes, Scalable Vacuum Filtration, and Adaptive Pre‐Clearing
Authors: Cohen Andy J. , Yuen Michelle C. , Corrigan Mady N. , Xu Siyi , Wood Robert J. 
Published: November 2024

AbstractNetworks of conductive nanoparticles have been used as electrodes for dielectric elastomer actuator multilayers because of their excellent extensibility and low added stiffness. Nanoparticle network topography, however, has typically effected a tradeoff between conductivity and breakdown strength. This has limited actuators to a corresponding tradeoff between either high operating frequencies and efficiencies or high stresses, strains, and energy densities. This tradeoff is resolved by spatially patterning multiple nanoparticles to produce hybrid electrodes. Sparse networks of high‐aspect‐ratio carbon nanotubes allow for self‐clearing in the body of the electrode, yielding 54.7 V µm−1 breakdown strength, 86.4% that of the neat elastomer. Dense networks of low‐aspect‐ratio carbon black at the external interfaces, meanwhile, provide low contact resistance (44.09 kΩmm). Two tools essential for their practical deployment are developed: a scalable fabrication process and an automated pre‐clearing algorithm. The fabrication method leverages the batch spray and stamp paradigm in concert with vacuum filtration to scalably deposit nanoparticle electrodes with minimal parameter tuning, enabling the production of a 100‐layer actuator capable of 14% strain. The adaptive pre‐clearing algorithm discriminates between and responds to a range of defect‐induced failures in newly fabricated actuators, eliminating the need for human oversight and standardizing the break‐in procedure.
Vacuum‐Sublimed Cocrystalline Thin Films of Naphthalene Bisimide and Pt(II) Complex for Phosphorescent Light‐Emitting Diodes
Authors: Brust Felix , Soldner Simon , Stepanenko Vladimir , Stolte Matthias , Würthner Frank 
Published: November 2024

AbstractCocrystals employing small organic molecules with platinum(II)‐complexes are known to exhibit organic room‐temperature phosphorescence (RTP). However, this desirable property is so far only demonstrated in the macroscopic 1:1 cocrystalline state, which limits device applications outside of small single‐crystal devices. Here, this work shows that vacuum cosublimed thin films of both components in various mixing ratios form layers with self‐assembled small cocrystalline domains which exhibit RTP. This Pt(II) doping improves the photoluminescence (PL) quantum yield (ΦPL) of the now phosphorescence emitting 1,8:4,5‐naphthalene bisimide (NBI) from below 0.1% to 9% in respective thin films. These doped layers are employed as active layers in light‐emitting diodes to emit red electroluminescence (EL). Via time‐resolved measurements the lifetime of the device EL is determined in accordance with the PL to be around 50 µs. Maximum external quantum efficiencies (EQEs) of over 0.2% with RTP emission signatures consistent with the PL of solution‐grown cocrystals could be achieved.
In Vivo Photopolymerization: Achieving Detailed Conducting Patterns for Bioelectronics
Authors: Ek Fredrik , Abrahamsson Tobias , Savvakis Marios , Bormann Stefan , Mousa Abdelrazek H. , Shameem Muhammad Anwar , Hellman Karin , Yadav Amit Singh , Betancourt Lazaro Hiram , Ekström Peter , Gerasimov Jennifer Y. , Simon Daniel T. , Marko‐Varga György , Hjort Martin , Berggren Magnus , Strakosas Xenofon , Olsson Roger 
Published: November 2024

AbstractBioelectronics holds great potential as therapeutics, but introducing conductive structures within the body poses great challenges. While implanted rigid and substrate‐bound electrodes often result in inflammation and scarring in vivo, they outperform the in situ‐formed, more biocompatible electrodes by providing superior control over electrode geometry. For example, one of the most researched methodologies, the formation of conductive polymers through enzymatic catalysis in vivo, is governed by diffusion control due to the slow kinetics, with curing times that span several hours to days. Herein, the discovery of the formation of biocompatible conductive structures through photopolymerization in vivo, enabling spatial control of electrode patterns is reported. The process involves photopolymerizing novel photoactive monomers, 3Es (EDOT‐trimers) alone and in a mixture to cure the poly(3, 4‐ethylenedioxythiophene)butoxy‐1‐sulfonate (PEDOT‐S) derivative A5, resulting in conductive structures defined by photolithography masks. These reactions are adapted to in vivo conditions using green and red lights, with short curing times of 5–30 min. In contrast to the basic electrode structures formed through other in situ methods, the formation of specific and layered patterns is shown. This opens up the creation of more complex 3D layers‐on‐layer circuits in vivo.
Optimizing Atomic and Electronic Structure of Antiperovskite Solid Electrolytes for Electrochemically Stable Interface of Lithium Metal Anodes
Authors: Kim Heebae , Jang Eunbin , Jin Huding , Yun Heejun , Lee Jeewon , Lee Jemin , Min Byeongyun , Yoon Si Hyun , Choi Won Jun , Yoo Jeeyoung , Kim Youn Sang 
Published: November 2024

AbstractSolid‐state batteries (SSBs) employing Li‐metal anodes (LMAs) show significant potential for overcoming the energy density limitations inherent in conventional Li‐ion batteries with graphite anodes. In the past decade, diverse approaches have tried to improve the cycling performance of SSBs, including chemical modifications of solid electrolytes (SEs) and designs of multifunctional interlayers. However, knowledge gaps regarding the physical characteristics of Li‐ion conducting inorganic SEs and the interfacial stability of LMAs are impeding advancements in battery technology. Herein, a practical strategy is developed to facilitate Li‐ion mobility and mitigate current constriction at the interfaces via manganese substitution into antiperovskite SEs, inspired by how liquid electrolyte additives modify the surface characteristics of LMAs. Due to the stable half‐filled 3d shell of manganese, the physically modified SE can achieve structural endurance and electrochemical compatibility with LMA. The Li symmetric cell employing this advanced SE demonstrates outstanding electrochemical performance at room temperature without external pressure. This cell configuration exhibits a high critical current density of 10.5 mA cm−2 and maintains its stable charge–discharge process over 4000 cycles at 10.0 mA cm−2. The findings here will advance the commercialization of SSBs by providing insights into the complicated solid‐solid interactions during battery operation.
Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing
Authors: Khattak Saadullah , Ullah Ihsan , Sohail Mohammad , Akbar Muhammad Usman , Rauf Mohd Ahmar , Ullah Salim , Shen Jianliang , Xu Hong‐Tao 
Published: November 2024

AbstractDiabetes significantly impairs the body's wound‐healing capabilities, leading to chronic, infection‐prone wounds. These wounds are characterized by hyperglycemia, inflammation, hypoxia, variable pH levels, increased matrix metalloproteinase activity, oxidative stress, and bacterial colonization. These complex conditions complicate effective wound management, prompting the development of advanced diabetic wound care strategies that exploit specific wound characteristics such as acidic pH, high glucose levels, and oxidative stress to trigger controlled drug release, thereby enhancing the therapeutic effects of the dressings. Among the solutions, hydrogels emerge as promising due to their stimuli‐responsive nature, making them highly effective for managing these wounds. The latest advancements in mono/multi‐stimuli‐responsive smart hydrogels showcase their superiority and potential as healthcare materials, as highlighted by relevant case studies. However, traditional wound dressings fall short of meeting the nuanced needs of these wounds, such as adjustable adhesion, easy removal, real‐time wound status monitoring, and dynamic drug release adjustment according to the wound's specific conditions. Responsive hydrogels represent a significant leap forward as advanced dressings proficient in sensing and responding to the wound environment, offering a more targeted approach to diabetic wound treatment. This review highlights recent advancements in smart hydrogels for wound dressing, monitoring, and drug delivery, emphasizing their role in improving diabetic wound healing. It addresses ongoing challenges and future directions, aiming to guide their clinical adoption.
Biosynthetic Origin of the Methoxy Group in Quinine and Related Alkaloids
Authors: Lombe Blaise Kimbadi , Zhou Tingan , Caputi Lorenzo , Ploss Kerstin , O'Connor Sarah E. 
Published: November 2024

AbstractQuinine is a historically important natural product containing a methoxy group that has been assumed to be incorporated at a late pathway stage. Here we show that the methoxy group in quinine and related alkaloids is introduced onto the starting substrate tryptamine. Feeding studies definitively show that 5‐methoxytryptamine is utilized as a quinine biosynthetic intermediate in planta. We discover the biosynthetic genes that encode the responsible oxidase and methyltransferase, and we use these genes to reconstitute the early steps of the alkaloid biosynthetic pathway in Nicotiana benthamiana to produce a mixture of methoxylated and non‐methoxylated alkaloid intermediates. Importantly, we show that the co‐occurrence of both tryptamine and 5‐methoxytryptamine substrates, along with the substrate promiscuity of downstream pathway enzymes, enable parallel formation of both methoxylated and non‐methoxylated alkaloids.
Synergistic π‐Extension and Peripheral‐Locking of B/N‐Based Multi‐Resonance Framework Enables High‐Performance Pure‐Green Organic Light‐Emitting Diodes
Authors: Xiao Shengbing , Cao Xiaosong , Chen Guohao , Yin Xiaojun , Chen Zhi , Miao Jingsheng , Yang Chuluo 
Published: November 2024

AbstractMulti‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters offer natural advantages for creating power‐efficient, wide‐color‐gamut OLEDs. However, current green MR‐TADF emitters face challenges in simultaneously achieving high color purity and efficient reverse inter‐system crossing (RISC), leading to suboptimal device performance. In this study, we propose a synergistic molecular design approach that combines π‐extension and peripheral locking to address these challenges. This approach allows for the construction of quadruple borylated MR‐TADF emitters that not only deliver precisely tuned pure‐green emission with a narrow full width at half maximum (FWHM) of 15 nm, but also exhibit close‐to‐unity quantum yield, rapid RISC, and optimal horizontal dipole orientation. The resulting sensitizer‐free OLED approaches the BT.2020 standard with CIE coordinates of (0.18, 0.74) and demonstrates impressive external quantum efficiency (EQE) of 36.6 % at maximum and 31.8 % at 1000 cd m−2. Additionally, the device shows good operational stability, with a lifetime (LT80) of 485 hours at an initial luminance of 1000 cd m−2. This study hence offers a promising molecular design strategy that effectively enhances the comprehensive OLED performance.
Glycerol esterification of free fatty acids catalyzed by zinc glycerolate for biodiesel production from acidified palm oil: Optimization, kinetic study, and process evaluation
Authors: Fei Haotian , Zheng Congwen , Wu Zhenyu , Liang Xiaojiang , Nie Yong 
Published: November 2024

AbstractBiodiesel is an important alternative renewable liquid fuel due to its eco‐friendly, non‐toxic, and lower emissions. In this work, glycerol esterification catalyzed by zinc glycerolate was employed as a pretreatment to prepare biodiesel from acidified palm oil. The effects of stirring rate, catalyst amount, glycerol to free fatty acids (FFAs) molar ratio, and reaction temperature on the conversion of FFAs and concentration of monoglycerides, diglycerides, and triglycerides were investigated and optimized. The results show that the conversion of FFAs could reach 99.16% under the optimized conditions. Moreover, the kinetics of glycerol esterification catalyzed by zinc glycerolate at 160–200°C was obtained. Additionally, a comprehensive evaluation of the new biodiesel production process was also conducted. As a result, higher biodiesel content in the crude biodiesel phase was obtained after transesterification and separation using this new process. Overall, the study contributes to the utilization of waste oils to produce renewable energy and to minimize the waste management problem.
Macromolecular metamorphosis of thermoplastic poly(thio)urethanes containing boronic acid esters
Authors: Schwarzl Philip , Koch Thomas , Liska Robert , Baudis Stefan 
Published: November 2024

AbstractBiodegradable thermoplastic polyurethanes (TPUs) are promising materials for vascular grafts, due to their excellent mechanical properties and the possibility to incorporate degradable moieties. Especially degradability is important in the field of tissue engineering (TE) or regenerative medicine, because the synthetic scaffold should be replaced by human tissue after a certain time. We synthesized thermoplastic polythiourethanes (TPTUs) based on degradable chain extenders and tested their mechanical, thermal and degradation characteristics. As soft‐block we used polytetrahydrofuran (pTHF) and as hard‐block the aliphatic hexamethylenediisocyanate (HMDI) in combination with a variety of chain extenders. The focus was set on the boronic acid‐based dithiol 2,2′‐(1,4‐phenylene)‐bis[4‐mercaptan‐1,3,2‐dioxaborolane] (BDB). As dithiol‐based reference 1,2‐bis(2‐mercaptoethoxy)ethane (BMEE) was used and bis(2‐hydroxyethyl)‐terephthalate (BHET) as well‐known ester‐based reference chain extender. By using BDB as degradable chain extender we could accelerate the degradation rate in terms of mass erosion at 37 and 90°C compared to BHET‐based TPUs. However, a strong increase in molecular weight was observed under degradation conditions. Further investigation by ATR‐FTIR revealed a release of benzene‐1,4‐diboronic acid (BDBA) in the polymer. This leads to the formation of a hydroxy‐terminated polyol, which then undergoes an intramolecular functional group metamorphosis with the thiourethane group to form a crosslinked polymer. BMEE‐based TPTUs in contrast show excellent mechanical properties, even better than BHET‐TPUs but a slightly lower mass erosion at 37 and 90°C.
Investigation of the Adaptability of Pt/HfO2/n+Si Memristors with Self‐Limiting Oxygen‐Deficient Hafnium Oxide Films under Repetitive Pulse Stimuli
Authors: Wang Kexiang , Lu Jie , Xiang Zeyang , Shi Mengrui , Wu Liuxuan , Yan Fuyu , Jiang Ran 
Published: November 2024

AbstractIn this study, the performance of memristive devices made of oxygen‐deficient HfO2 films is investigated when exposed to various electrical pulse stimulations. The devices exhibited signs of fatigue with the number increasing of a fixed frequency pulse, mirroring the synaptic adaptation to repeat stimuli. Interestingly, the synaptic behavior can be highly simulated by logic function, and the pulse frequency and magnitude play different roles in changing the synaptic curves. Only pulses with certain quantized frequencies can reshape the synaptic current response curve. In addition, a similarity is observed between the frequency stability of these devices and the biological lifespan in response to external stimuli. These observations strengthen the case for the potential of memristors in emulating cognitive functions.
Unveiling tomorrow: Carbonic anhydrase activators and inhibitors pioneering new frontiers in Alzheimer's disease
Authors: Mishra KM Abha , Sethi Kalyan K. 
Published: November 2024

AbstractAlzheimer's disease (AD) is a neurodegenerative disorder and a principal basis of dementia in the elderly population globally. Recently, human carbonic anhydrases (hCAs, EC 4.2.1.1) were demonstrated as possible new targets for treating AD. hCAs are vital for maintaining pH balance and performing other physiological processes as they catalyze the reversible hydration of carbon dioxide to bicarbonate and a proton. Current research indicates that hCA plays a role in brain functions critical for transmitting neural signals. Activation of carbonic anhydrase (CA) has emerged as a promising avenue in addressing memory loss and cognitive issues. Conversely, the exploration of CA inhibition represents a novel frontier in this field. By enhancing glial fitness and cerebrovascular health and blocking amyloid‐β (Aβ)‐induced mitochondrial dysfunction pathways, cytochrome C (CytC) release, caspase 9 activation, and H2O2 generation in neurons, CA inhibitors improve cognition and lessen the pathology caused by Aβ. Recent research has pushed hCAs into the spotlight as critical players in AD pathogenesis and precise therapeutic targets. The captivating dilemma of choosing between hCA inhibitors and activators looms large, as inhibitors reduce Aβ aggregation and improve cerebral blood flow, while activators enhance cerebrovascular functions and restore pH balance. The current review sheds light on the clinical evidence for hCAs and the roles of inhibitors and activators in AD. Additionally, this review offers a fascinating outlook on the data that may aid medicinal chemists in designing and developing new leads that are more effective and selective for upcoming in vitro and in vivo studies, allowing for the discovery and introduction of novel drug candidates for the treatment of AD to the market and into the clinical pipeline.
Spatio‐temporal localization of P21‐activated kinase in endometrial cancer
Authors: Roy Joydeep , Hemavathy Nagarajan , Saravanan Roshni , Gopinath Prarthana , Pugazh Pooja , Jeyaraman Jeyakanthan , Venkatraman Ganesh , Rayala Suresh Kumar 
Published: November 2024

AbstractEndometrial cancer is the sixth most common gynecologic cancer, and has been reported as a malignancy arising due to the idiopathic effects of certain anticancer agents. Tamoxifen is the drug of choice in ER‐positive breast cancer, and several studies have shown better disease‐free survival in these patients. However, the long‐term usage of tamoxifen has been associated with resistance and risk for endometrial malignancy. A direct mechanistic basis for tamoxifen‐induced endometrial tumorigenesis is still unclear. Hyperactivation of PAK1 in endometrial cancer correlates with poor overall survival. The present study demonstrates that tamoxifen treatment induces nuclear localization of PAK1 in endometrial carcinoma cells. This nuclear transit is mediated through JAK2 phosphorylation of PAK1 and binding of β‐PIX. In addition, a computational approach involving molecular modeling and simulation of phosphorylated and unphosphorylated forms of PAK1 was used to elucidate the dynamics of nuclear localization. Thus, PAK1 phosphorylation by JAK2 is a prerequisite for its nuclear localization and its tumorigenic effects on endometrial cancer cells.