bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the heating of a two-dimensional slab in a microwave cavity: aperture effects
Authors: Marchant T. R. , Liu B. 
Published: May 2019

AbstractThe steady-state heating of a two-dimensional slab by the TE10 mode in a microwave cavity is considered. The cavity contains an iris with a variable aperture and is closed by a short. Resonance can occur in the cavity, which is dependent on the short position, the aperture width and the temperature of the heated slab.The governing equations for the slab are steady-state versions of the forced heat equation and Maxwell's equations while fixed-temperature boundary conditions are used. An Arrhenius temperature dependency is assumed for both the electrical conductivity and the thermal absorptivity. Semi-analytical solutions, valid for small thermal absorptivity, are found for the steady-state temperature and the electric-field amplitude in the slab using the Galerkin method.With no-iris (a semi-infinite waveguide) the usual S-shaped power versus temperature curve occurs. As the aperture width is varied however, the critical power level at which thermal runaway occurs and the temperature response on the upper branch of the S-shaped curve are both changed. This is due to the interaction between the radiation, the cavity and the heated slab. An example is presented to illustrate these aperture effects. Also, it is shown that an optimal aperture setting and short position exists which minimises the input power needed to obtain a given temperature.
The parameter dependent Sturm-Liouville eigenproblem with an interior simple or double pole
Authors: Acho Thomas M. , Clemence Dominic P. 
Published: May 2019

AbstractBoundary value problems where resonance phenomena are studied are most often transformable to parameter dependent Sturm-Liouville (SL) eigenproblems with interior singularities. The parameter dependent Sturm-Liouville eigenproblem with interior poles is examined. Asymptotic approximations to the solutions are obtained using an extended Langer's method to take care of the resulting complex eigenvalues and eigenfunctions.
Solvability of some Abel-type integral equations involving the Gauss hypergeometric function as kernels in the spaces of summable functions
Authors: Raina R. K. , Srivastava H. M. , Kilbas A. A. , Saigo M. 
Published: May 2019

AbstractThis paper is devoted to the study of the solvability of certain one-and multidimensional Abel-type integral equations involving the Gauss hypergeometric function as their kernels in the space of summable functions. The multidimensional equations are considered over certain pyramidal domains and the results obtained are used to present the multidimensional pyramidal analogues of generalized fractional calculus operators and their properties.
Sand‐Mud Tidal Flat Morphodynamics Influenced by Alongshore Tidal Currents
Authors: Wang Yunwei , Wang Ya Ping , Yu Qian , Du Zhiyun , Wang Zheng Bing , Gao Shu 
Published: May 2019

AbstractTidal flats, where significant land‐ocean interactions take place, are often abstracted as a cross‐shore bed profile with sediment zonation from the lower sand flat to the upper mud flat. However, in addition to cross‐shore tidal currents, the impact of the alongshore components on cross‐shore sediment transport, morphological evolution, and sediment grain‐size change remains unclear. Here we investigated sand‐mud tidal flat morphodynamics in the absence of waves by combining approaches of field observations, numerical modeling, and analytical interpretations, based on the example of the tidal flat on the central Jiangsu coast, China. The results show that the morphodynamic processes are complicated by the interactions of cross‐shore and alongshore tidal currents, cross‐shore flat morphology, and sediment zonation. With amplified phase lags of the alongshore tidal level at the boundaries, alongshore currents become dominant over cross‐shore tidal currents on the lower flat, while the upper flat is always dominated by the cross‐shore currents. Therefore, bed profiles and mud content on the upper flat were independent of the alongshore tidal current magnitude, being convex‐up and consisting of mud. In contrast, the strong alongshore currents can erode mud on the lower flat and promote landward sand transport from the subtidal area to the lower flat, forming a sand flat. The maximum tidal bed shear stress is almost spatially uniform across the muddy area but pronouncedly elevated where the bed sediment coarsens on the lower flat. The contributions of the alongshore tidal currents and sand‐mud sorting processes should be appropriately addressed in similar coastal environments.
Long‐Term Mean Mass, Heat and Nutrient Flux Through the Indonesian Seas, Based on the Tritium Inventory in the Pacific and Indian Oceans
Authors: Xie Tengxiang , Newton Robert , Schlosser Peter , Du Chuanjun , Dai Minhan 
Published: May 2019

AbstractThe Indonesian Throughflow (ITF), the only oceanic tropical pathway linking the Pacific and Indian Oceans, plays a critical role in the redistribution of heat and mass, affecting both the regional and global climate systems. Based on the distributions and changes in the tritium inventories, and tritium budgets in and between the South Pacific and South Indian Oceans from the Geochemical Ocean Sections Study and World Ocean Circulation Experiment programs, the long‐term mean water mass transport of the ITF is estimated. The total throughflow of the ITF is estimated as 16.2 ± 3.5 Sv. The North Pacific contributes 14.1 ± 2.7 Sv to the total throughflow, of which the layers between 0–250, 250–650, and 650–1,000 m carry 7.3 ± 0.6, 5.4 ± 1.3, and 1.4 ± 3.0 Sv, respectively. Along with the water transport, the North Pacific component of the ITF transfers 0.84 ± 0.14 PW of heat into the Indian Ocean, of which almost 90% exits from the Indian Ocean at 30°S. The net nitrate flux into the photic zone associated with the ITF is 2.71 ± 2.60 mmol·m−2·d−1 in the Indonesian Seas, ~90% of which is induced by vertical diffusion.
The Proto‐Zagros Foreland Basin in Lorestan, Western Iran: Insights From Multimineral Detrital Geothermochronometric and Trace Elemental Provenance Analysis
Authors: Barber Douglas E. , Stockli Daniel F. , Galster Federico 
Published: May 2019

AbstractDetrital zircon (DZ) U‐Pb geochronology is a widely used provenance tool that leverages bedrock age signatures of hinterland source terranes. However, complex sediment recycling of multicycle zircon and hinterland provinces with nondiagnostic U‐Pb ages represent possible pitfalls for provenance reconstructions. Additional biases pertain to source rock zircon fertilities and insensitivity to low‐ and medium‐grade tectonothermal events that do not result in zircon generation. To bridge these inherent biases and gaps in DZ U‐Pb provenance data sets and derive more comprehensive tectonic reconstruction, this study combined U‐Pb and trace element analyses on DZ, apatite, and rutile as well as zircon (U‐Th)/He analyses from the Proto‐Zagros foreland basin in western Iran to shed light on Late Cretaceous tectonic accretion along Arabia. Integrated multimineral, multimethod data sets record formation of a 110‐ to 85‐Ma island arc within Triassic mid‐oceanic ridge crust of the Neotethys ocean, simultaneous obduction starting in Santonian‐Early Campanian times, and inversion of the Arabian rift margin. Overall, integration of these techniques constrains provenance based on multiple independent criteria including crystallization age, cooling history, and petrogenic‐geodynamic environment. This approach not only more completely described provenance signatures but also helped avoid significant pitfalls. For example, while Triassic DZ U‐Pb ages might be mistaken as input from Eurasia, zircon trace element analysis reveals a MORB signature and attributes these DZ to Neotethyan oceanic rather than Eurasian continental origin, having fundamentally different paleogeographic/tectonic implications for the Arabia‐Eurasia collision. Moreover, detrital rutile and apatite resolve and characterize multiple Paleozoic‐Mesozoic thermotectonic events not recorded by DZ U‐Pb due to their largely amagmatic nature.
On resolving ambiguities in microbial community analysis of partial nitritation anammox reactors
Authors: Orschler Laura , Agrawal Shelesh , Lackner Susanne 
Published: May 2019

AbstractPCR-based methods have caused a surge for integration of eco-physiological approaches into research on partial nitritation anammox (PNA). However, a lack of rigorous standards for molecular analyses resulted in widespread data misinterpretation and consequently lack of consensus. Data consistency and accuracy strongly depend on the primer selection and data interpretation. An in-silico evaluation of 16S rRNA gene eubacterial primers used in PNA studies from the last ten years unraveled the difficulty of comparing ecological data from different studies due to a variation in the coverage of these primers. Our 16S amplicon sequencing approach, which includes parallel sequencing of six 16S rRNA hypervariable regions, showed that there is no perfect hypervariable region for PNA microbial communities. Using qPCR analysis, we emphasize the significance of primer choice for quantification and caution with data interpretation. We also provide a framework for PCR based analyses that will improve and assist to objectively interpret and compare such results.
The Effect of Freezing on Non-invasive Prenatal Testing
Authors: Xie Xiaolei , Li Fuguang , Tan Weihe , Yin Weiguo , Chen Feiyan , Guo Xiaoyan 
Published: May 2019

AbstractPlasma cryopreservation is unavoidable in China, due to technical specifications requiring storage of additional plasma at −80 degrees for three years. However, the effect of freezing on non-invasive prenatal testing (NIPT) is still uncertain. We collected 144 euploid pregnant samples, 22 on trisomy 21, 4 on trisomy 13, and 3 on trisomy 18, by massively parallel sequencing before and after freezing. Compared with the success rate of 100% of fresh samples, the detection success rates of trisomy 21, trisomy 13 and euploidy in frozen samples by NIPT were 95.45%, 75% and 95.14%, respectively. Of these, 9 cases of frozen sample sequencing failed, with 8 cases being due to high GC content. The chromosome 21 (chr21) z-value of the frozen trisomy 21 samples was lower than that of fresh samples. Meanwhile, freezing reduced the male positive foetal cell-free DNA (cfDNA) fraction, which was accompanied by an increase in the Unimap-GC level in the massively parallel sequencing data and a decrease in the Unique reads/Total reads ratio. Laboratory freezing reduced the chr21 z-value of foetal trisomy 21, which can be explained by a reduction in the foetal cfDNA fraction and effective Unique reads for NIPT analysis. The Unimap-GC content of the serum samples after freezing was higher, which can lead to failure of NIPT detection.
Visualizing the cellular route of entry of a cystine-knot peptide with Xfect transfection reagent by electron microscopy
Authors: Gao Xinxin , De Mazière Ann , Iaea David B. , Arthur Christopher P. , Klumperman Judith , Ciferri Claudio , Hannoush Rami N. 
Published: May 2019

AbstractCystine-knot peptides are attractive templates in drug discovery due to a number of features they possess including their 3D conformation, physicochemical stability and synthetic tractability. Yet, their cellular uptake mechanisms remain largely unexplored. Recently, we demonstrated that the cystine-knot peptide EETI-II is internalized into cells and that its cellular uptake could be modulated by using a protein transfection reagent Xfect. However, the mechanism of Xfect-mediated cellular internalization of EETI-II remained unclear. Here, by using high resolution electron microscopy, we observe the formation of EETI-II-positive macropinosomes and clathrin-coated pits at early time points after treatment of cells with EETI-II/Xfect complexes. Internalized EETI-II subsequently accumulates in intracellular Xfect-induced detergent-resistant membrane compartments which appear to lack characteristic endosomal or lysosomal markers. Notably, Xfect enables the uptake of cell impermeable nuclear dyes into similar intracellular compartments that do not seem to deliver the cargo to the cytosol or nucleus. Altogether, our findings reveal mechanistic insights into the cellular uptake route of Xfect, and underscore the need for the development of effective tools to enhance the cytosolic delivery of cystine-knot peptides. Finally, our data illustrate that electron microscopy is a powerful approach for studying endocytic mechanisms of cell-penetrating peptides and their effects on cellular membranes.
Map-based cloning of QFhb.mgb-2A identifies a WAK2 gene responsible for Fusarium Head Blight resistance in wheat
Authors: Gadaleta Agata , Colasuonno Pasqualina , Giove Stefania Lucia , Blanco Antonio , Giancaspro Angelica 
Published: May 2019

AbstractFusarium graminearum is one of the most threating pathogen of wheat, responsible for Fusarium head blight (FHB) which annually leads to yield losses, grain quality decay and accumulation of harmful mycotoxins in kernels. Host resistance represents the most effective approach to limit disease damages; however, only a limited number of resistant loci have currently been detected in durum genotypes. In this work we report the map-based cloning of a FHB-QTL on 2A chromosome of durum wheat, introgressed from a resistant line derived from the Chinese wheat cv. Sumai-3. A marker enrichment of the QTL region was carried out leading to the inclusion of 27 new SNPs respect to the previous map. A wall-associated receptor-like kinase (WAK2) gene was identified in the region and sequenced, in the resistant parent (RP) one gene was predicted accounting for a genomic sequence of 5,613 structured into 6 exons, whereas two adjacent genes were predicted on the same DNA plus strand of the susceptible parent (SP).t The involvement of WAK2 gene in FHB resistance mechanism was assessed by gene expression comparison between resistant and susceptible wheat lines, and disease symptoms evaluation in 3 TILLING mutants for WAK protein function.
Blueprint for nanoscale NMR
Authors: Schwartz Ilai , Rosskopf Joachim , Schmitt Simon , Tratzmiller Benedikt , Chen Qiong , McGuinness Liam P. , Jelezko Fedor , Plenio Martin B. 
Published: May 2019

AbstractNitrogen vacancy (NV) centers in diamond have been used as ultrasensitive magnetometers to perform nuclear magnetic resonance (NMR) spectroscopy of statistically polarized samples at 1–100 nm length scales. However, the spectral linewidth is typically limited to the kHz level, both by the NV sensor coherence time and by rapid molecular diffusion of the nuclei through the detection volume which in turn is critical for achieving long nuclear coherence times. Here we provide a blueprint supported by detailed theoretical analysis for a set-up that combines a sensitivity sufficient for detecting NMR signals from nano- to micron-scale samples with a spectral resolution that is limited only by the nuclear spin coherence, i.e. comparable to conventional NMR. Our protocol detects the nuclear polarization induced along the direction of an external magnetic field with near surface NV centers using lock-in detection techniques to enable phase coherent signal averaging. Using the NV centers in a dual role of NMR detector and optical hyperpolarization source to increase signal to noise, and in combination with Bayesian inference models for signal processing, nano/microscale NMR spectroscopy can be performed on sample concentrations in the micromolar range, several orders of magnitude better than the current state of the art.
Randomized comparison between indocyanine green fluorescence plus 99mtechnetium and 99mtechnetium alone methods for sentinel lymph node biopsy in breast cancer
Authors: Vermersch Charlotte , Raia-Barjat Tiphaine , Chapelle Céline , Lima Suzanne , Chauleur Céline 
Published: May 2019

AbstractUse of both patent blue and a radioisotope to locate, and reduce the risk of sentinel lymph node (SLN) detection failure in breast cancer is recommended, but drawbacks commonly lead to using only a radioisotope. An alternative method would therefore be valuable. This randomized, controlled study in 99 patients compared SLN detection using 99mtechnetium (Tc) alone versus Tc combined with indocyanine green (ICG). The primary endpoint was the SLN identification rate. The primary outcome measure was the number of patients with <2 SLN detected. One SLN was detected in 44.0% of patients in the dual detection group and 40.8% in the 99mTc alone group (RR = 1.08 (95% CI 0.68; 1.72), p = 0.84). A mean (±SD) of 2.14 ± 1.23 SLN were identified in the dual detection group vs. 1.77 ± 0.85 using Tc alone (p = 0.09). Eight-five (78.7%) SLN were both ICG+ and TC+, 15 (13.9%) ICG+ and Tc−, and 7 (6.5%) ICG− and Tc+. SLN detected were ICG-positive in 92.6% of patients and 99mTc-positive in 85.2% with. No adverse event related to ICG injection was recorded. Dual detection of SLN using ICG and radioisotope is reliable and sensitive but was not superior to isotope alone in successfully locating SLN in our pilot randomized trial.
Investigation of evolutionary and expressional relationships in the function of the leucine-rich repeat receptor-like protein kinase gene family (LRR-RLK) in the radish (Raphanus sativus L.)
Authors: Wang Jinglei , Hu Tianhua , Wang Wuhong , Hu Haijiao , Wei Qingzhen , Bao Chonglai 
Published: May 2019

AbstractThe leucine-rich repeat receptor-like protein kinase (LRR-RLK) plays an important role in plant development and disease defence. Although genome-wide studies of LRR-RLKs have been performed in several species, a comprehensive analysis, including evolutionary, structural and expressional analyses and their relationships to function, has not been carried out in the radish (Raphanus sativus L.). In this study, we identified 292 LRR-RLK genes in the R. sativus genome and classified them into 23 subgroups. The subgroups containing genes involved in defence were more likely to evolve from tandem duplication rather than whole genome triplication (WGT), had lower expression profiles and were expressed in fewer tissues than the subgroups related to development. Gene structures and conserved domains did not differ in the defence-related or development-related subgroups, but they were distinct in each subgroup. This study sheds light on the evolutionary and expressional relationships with the functions of R. sativus LRR-RLKs and provides an integrated framework for additional investigation into these functions.
Absorbed dose evaluation at different organs after 131I oral contamination of two Wistar rat models
Authors: Mezaguer-Lekouaghet Meriem , Blanchardon Eric , Badreddine Abdelwahab , Bertho Jean-Marc , Souidi Maamar , Baz Ahcène , Lounis-Mokrani Zohra 
Published: May 2019

Iodine-131 (131I) is one of the most frequently used radionuclides for diagnosis and therapy of thyroid diseases. It is administered orally in the treatment of cancer to eliminate the residual postoperative microscopic tumor foci, and the residual normal thyroid tissue for early detection of recurrence [1].
The comparative behavior of 131I concentration into two animalmodels with total and partial thyroid has been investigated in our previous work [2]. The accumulated activities have been measured in fourteen organs.
In this study, the mean absorbed doses resulting from 131I accumulated in all organs have been evaluated using RODES software [3, 4]. With this software, mean absorbed doses were calculatedfor selected organs (thyroid, lungs, heart, liver, kidneys, stomach, spleen, large and small intestine, testes, urinary bladder wall) by combining the specific absorbed fractions (SAF) of energy with radiation emission spectra and biokinetic data determined from our previous experimental study [2]. Calculations were based on the 131I photon and electron emissions reported by [5] and SAFs previously calculated by Monte Carlo simulation in the voxel phantom of an adult male rate [3, 4].
The obtained results show high absorbed dosesdeliveredto stomach and lungs for both models compared to other organs. The dose received by the testes and salivary glands is found to be higher in the case of the rat model without thyroid. Conversely, the spleen and bladder wall received lower doses in this latter model compared to those received by the rat model with thyroid. One can also note that the difference in mean absorbed dose received by liver, lungs, heart, and walls of the stomach is not significant between the two rat models.
Die neue Sepsisdefinition: Sepsis-3
Authors: Brunkhorst Frank M. 
Published: May 2019

ZusammenfassungSeit 2016 existiert eine neue Sepsisdefinition, die erstmals die Sepsis auf
Normalstationen und Notaufnahmen in den Vordergrund stellt. Dazu gehört auch ein
diagnostischer Score, der dabei hilft, Patienten mit einem hohen Sepsisrisiko so
früh wie möglich zu identifizieren.
Pflegerische Expertise ist obligat
Authors: Krüger Lars , Mosel Jens , Bergmeier Susanne 
Published: May 2019

ZusammenfassungDie pflegerische und medizinische Versorgung von Patienten mit einer ECMO ist in
Deutschland längst keine Seltenheit mehr. Allein in der Klinik für Thorax- und
Kardiovaskularchirurgie im Herz- und Diabeteszentrum Nordrhein-Westfalen wurden
im Jahr 2017 mehr als 200 Patienten mit einem entsprechenden System versorgt.
Viele bis heute veröffentlichte Artikel bilden häufig medizinische oder
medizintechnische Aspekte der ECMO ab. Der vorliegende Artikel möchte einen
Beitrag zum Thema „ECMO und Pflege“ leisten. Er fokussiert besonders die
Bereiche Bewegung und Mobilisation sowie die Patientensicherheit.
Palliative Pflege auf der Intensivstation
Authors: Knecht Christiane , Buchholz Dorothea , Dreseler Jacqueline , Kröger Birgit , Luding Manuela , Oelschläger Simone , Sorber Michaela , Wiebe Jenny 
Published: May 2019

ZusammenfassungKurative oder palliative Therapie? Gerade auf Intensivstationen stellt sich diese
Frage häufig. Mittendrin im Abstimmungsprozess des interdisziplinären Teams: die
Pflegekraft. Sie soll die Entscheidung des Teams in entsprechende
Pflegehandlungen umsetzen. Eine Gratwanderung zwischen dem Willen des Patienten
und seiner Familie, beruflichen Verpflichtungen, klinischen Entscheidungen und
dem Arbeitgeber.
Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins
Authors: Ríos José-Luis , Andújar Isabel , Schinella Guillermo R. , Francini Flavio 
Published: May 2019

AbstractIncretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation of incretin receptor signaling. Among these, soluble fiber from species of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors, and derivatives of cyanidin, especially diglycosylated ones, are an interesting source of dipeptidyl peptidase-4 inhibitors.