bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global burden of zoonotic infectious diseases of poverty, 1990–2021
Authors: Lv Chao , Chen Yiwen , Cheng Zile , Zhu Yongzhang , Chen Weiye , Zhou Nan , Chen Yiming , Li Yinlong , Deng Wangping , Guo Xiaokui , Li Min , Xu Jing 
Published: November 2024

Abstract
Background
The zoonotic infectious diseases of poverty (zIDPs) are a group of diseases contributing to global poverty, with significant impacts on a substantial population. This study aims to describe the global, regional, and national burden of zIDPs—schistosomiasis, cystic echinococcosis, cysticercosis, and food-borne trematodiases (FBTs)—to support policy making and resource allocation for their control and elimination.

Methods
Data of zIDPs from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 were retrieved from 1990 to 2021. The age-standardized prevalence rate (ASPR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life-year (DALY) rate were described and the estimated annual percentage changes (EAPCs) were calculated to quantify their burden and temporal trends. Spearman correlation analysis was conducted to examine the relationship between age-standardized rates and Socio-demographic Index (SDI).

Results
In 2021, these zIDPs exhibited a certain level of ASPRs and age-standardized DALY rates, while maintaining relatively low ASMRs. Noticeably, schistosomiasis presented the highest ASPR of 1914.299 (95% UI: 1378.920, 2510.853 per 100,000 population) and an age-standardized DALY rate of 21.895 (95% UI: 12.937, 37.278 per 100,000 population) among the zIDPs. The tapestry of burden—woven predominantly through low and lower-middle SDI regions—stretched across Africa, Latin America, and parts of Asia. From 1990 to 2021, a kaleidoscopic shift was observed globally as ASPRs, ASMRs, and age-standardized DALY rates declined significantly, as reflected by the EAPC values. Negative correlations were observed between the ASPRs, ASMRs, age-standardized DALY rates of schistosomiasis (r value = − 0.610, − 0.622 and − 0.610), cystic echinococcosis (− 0.676 of ASMR, − 0.550 of age-standardized DALYs), cysticercosis (− 0.420, − 0.797 and − 0.591) and the SDI. In contrast, a slight positive correlation was noted between the ASPR, age-standardized DALY rates of FBTs and SDI with r value of 0.221 and 0.213, respectively.

Conclusion
The burden of zIDPs declined across almost all endemic regions from 1990 to 2021, yet still predominated in low and low-middle SDI regions. Substantial challenges exist to achieve the goal of control and elimination of zIDPs, and integrated approaches based on One Health need to be strengthened to improve health outcomes.

Graphical Abstract
Changes in legal referrals to specialty substance use disorder treatment from 2015–2019
Authors: Fry Carrie E. , Harris Jacob , Burns Marguerite E. 
Published: November 2024

Abstract
Background
The policy landscape around substance use has changed dramatically in the past decade, which may have affected the number and characteristics of treatment episodes for substance use disorder (SUD). In this study, we examine changes in the volume of SUD treatment referrals from the legal system and compare changes in the composition of substances used by referral source. We used publicly available discharge data on specialty SUD treatment episodes in the U.S. from 2015–2019 and included episodes involving adults that are discharged from specialty SUD treatment facilities during the study. We calculated descriptive statistics of specialty SUD treatment discharges in each year and aggregated across all years by referral source and substance(s) reported upon admission. To test differences by year and referral source, we conducted z-tests of proportions.

Results
The proportion of referrals to specialty SUD treatment from the legal system declined between 2015 and 2019 (p < 0.001). However, referrals from probation/parole and diversionary programs grew over time (p < 0.001) in number and proportion over time. Legal referrals were most often associated with alcohol or cannabis use, though referrals for these substances declined from 2015–2019.

Conclusions
This research lays the groundwork for future investigations to evaluate the effect of important policy changes on referral sources to specialty SUD treatment and the quality and outcomes associated with referrals to treatment from the legal system.
"Re-thinking equity: the need for a multidimensional approach in evaluating educational equity through TIMSS data"
Authors: Appels Lies , De Maeyer Sven , Van Petegem Peter 
Published: November 2024

Abstract
Background
In recent years, data derived from international large-scale assessments have significantly influenced the discourse surrounding educational equity. However, the use of such data has often neglected the full spectrum of dimensions that equity encompasses, while being limited to exploring the relationship between achievement variations and student background. This approach, however, constrains our understanding of the rich notion.

Methods
This paper aims to contribute to the advancement of current research by advocating for an alternative approach that encompasses all relevant dimensions of equity and examines their impact on both achievement and motivational outcomes. A cluster analysis manifests itself as the designated method to employ, as the concept of equity remains theoretically challenged and the detection of data patterns can serve as a strong step in its multifaceted inquiry. Moreover, this method enables us to incorporate the multidimensional concept in a country-level context.

Results
Employing data from the Trends in International Mathematics and Science Study at grade four, this paper presents five distinct clusters of educational systems that illustrate diverse equity configurations. Notably, none of the identified clusters consistently scores high or low on all equity dimensions. This suggests that all of the clusters perform inconsistently to different degrees across the dimensions of equity. Furthermore, no single cluster emerges as superior to the others across both outcome measures.

Conclusions
These findings shed light on the intricate interplay between equity, achievement, and motivation within the examined educational systems. The unique configuration of the equity dimensions within each cluster underscores the importance of adopting a nuanced evaluation of equity, which can enhance our understanding of equity patterns.
The sodium/ascorbic acid co-transporter SVCT2 distributes in a striated membrane-enriched domain at the M-band level in slow-twitch skeletal muscle fibers
Authors: Sandoval Daniel , Mella Jessica , Ojeda Jorge , Bermedo-García Francisca , Low Marcela , Marcellini Sylvain , Castro Maite A. , Casas Mariana , Jaimovich Enrique , Henríquez Juan Pablo 
Published: November 2024

Abstract
Background
Vitamin C plays key roles in cellular homeostasis, functioning as a potent antioxidant and a positive regulator of cell differentiation. In skeletal muscle, the vitamin C/sodium co-transporter SVCT2 is preferentially expressed in oxidative slow fibers. SVCT2 is up-regulated during the early fusion of primary myoblasts and decreases during initial myotube growth, indicating the relevance of vitamin C uptake via SVCT2 for early skeletal muscle differentiation and fiber-type definition. However, our understanding of SVCT2 expression and function in adult skeletal muscles is still limited.

Results
In this study, we demonstrate that SVCT2 exhibits an intracellular distribution in chicken slow skeletal muscles, following a highly organized striated pattern. A similar distribution was observed in human muscle samples, chicken cultured myotubes, and isolated mouse myofibers. Immunohistochemical analyses, combined with biochemical cell fractionation experiments, reveal a strong co-localization of SVCT2 with intracellular detergent-soluble membrane fractions at the central sarcomeric M-band, where it co-solubilizes with sarcoplasmic reticulum proteins. Remarkably, electrical stimulation of cultured myofibers induces the redistribution of SVCT2 into a vesicular pattern.

Conclusions
Our results provide novel insights into the dynamic roles of SVCT2 in different intracellular compartments in response to functional demands.
Graphitic carbon nitride-modified cerium ferrite: an efficient photocatalyst for the degradation of ciprofloxacin, ampicillin, and erythromycin in aqueous solution
Authors: Adewuyi Adewale , Oderinde Rotimi A. 
Published: November 2024

AbstractIncomplete removal of antibiotics by most known wastewater treatment plants is a global challenge. Therefore, graphitic carbon nitride-modified cerium ferrite (CeFe2O4@g-C3N4) was synthesized to remove antibiotics (ampicillin, ciprofloxacin and erythromycin) from water. CeFe2O4@g-C3N4 showed activity in the visible light with a Tauc plot revealing the bandgap energy (2.46 eV). The scanning electron micrograph (SEM) result revealed the surface of CeFe2O4@g-C3N4 to be heterogeneous, while the transmission electron micrograph (TEM) image confirmed a flaky with rod and oval shaped surface (average particle size of 42.22 nm). CeFe2O4@g-C3N4 exhibited a 100% removal of all the studied antibiotics from aqueous solution in a photocatalytic degradation that is described by pseudo-1st-order kinetics. CeFe2O4@g-C3N4 demonstrated a high regeneration capacity, which is above 90% at the 12th cycle of treatment without any observable changes in its phase structure which suggests a promising chemical stability and reusability. CeFe2O4@g-C3N4 compared favourably with some selected antibiotic degradable photocatalysts suggesting the economic viable of CeFe2O4@g-C3N4 as photocatalyst for the purification of antibiotics-contaminated water.

Graphical Abstract
The COVID-19 restrictions, child services and the well-being of children in South Africa
Authors: Marais Lochner , Matamanda Abraham , Gbadegesin Frances , Ntema John , Mgwele Abongile , Dunn Mischka , Nel Verna , Lehobo Timothy M. , Andres Lauren , Denoon-Stevens Stuart 
Published: November 2024

AbstractCovid-19 posed little danger to children. Nevertheless, the South African government imposed lockdown measures that impeded children’s education, play and food. Schools were closed, feeding schemes were halted and organised sports were banned. In this study of South African children’s experience during the 2020–22 pandemic, we use the capabilities approach, particularly Nussbaum’s ten capabilities, to assess how the lockdown measures affected their development. The one-dimensional nature of the government response was evident in its focus on physical health and safeguarding adults and the health system, at the expense of children’s well-being. Children were masked and their voices were not heard. Despite being far less at risk of illness or death than adults, children and young people were disproportionately affected by government regulations. Children from low-income environments were particularly severely affected.
Engagement of people with lived experience in studies published in high-impact psychiatry journals: meta-research review
Authors: Adams Claire , Nassar Elsa-Lynn , Nordlund Julia , Hu Sophie , Rice Danielle B. , Cook Vanessa , Boruff Jill , Thombs Brett D. 
Published: November 2024

Abstract
Background
We evaluated studies published in high-impact psychiatry journals to assess (1) the proportion that reported in articles whether they engaged people with lived experience; (2) the proportion that likely engaged people with lived experience; and, if engagement occurred, (3) stages of research (planning, conduct, interpretation, dissemination); and (4) engagement level (consult, involve, partner).

Methods
We searched PubMed on December 14, 2022, for articles in psychiatry journals with impact factor ≥ 10 and reviewed articles in reverse chronological order until 141 were included, based on pre-study precision estimation. We contacted authors to obtain information on engagement.

Results
Three of 141 (2%) studies reported engagement of people with lived experience in articles. Of the other 138 studies, 74 authors responded to follow-up emails and 22 reported they engaged people with lived experience but did not report in the article. Depending on assumptions about engagement by non-responders, we estimated, overall, 18-31% of studies may have engaged people with lived experience. Engagement occurred in research planning (70%) and rarely interpretation (35%). Most involved consultation (providing opinions or perspectives, 53%) and few involved partnership (11%).

Conclusions
Engagement of people with lived experience in psychiatry research is uncommon, and when it does occur people are typically consulted but not engaged in roles with influence on decision-making. Funding agencies, ethics committees, journals, and academic institutions should take steps to support engagement of people with lived experience in psychiatry research.
Empowering sustainability: bridging science, community, and youth for a brighter future
Authors: Yousuf Ronika , Zehra Angeleen 
Published: November 2024

Abstract
Background
Sustainability science has become a crucial aspect of interdisciplinary research aimed at finding practical solutions and driving lasting change. This article examines the challenges facing sustainability science to move beyond the analysis of problems within interconnected systems and critically evaluate the interplay of social, political, and technological factors in the application of knowledge to action.

Results
The study highlights the influence of innovation implemented by companies on their sustainability performance, the establishment of innovations that positively affect sustainability performance, and analyzes the youth and local community perspectives on scientific innovations for a sustainable future.

Conclusions
The main conclusion is that sustainable development needs to focus on four areas of research: the impact of values ​​on research and decisions; community perspectives on sustainability; fostering socio-technical progress; and promoting learning for sustainable development. By decoding science, positive change can be achieved through the implementation of strategies such as transparency, understandability, and openness to scientific knowledge.
Effectiveness of telerehabilitation-based mckenzie method versus manual therapy in low-back pain management: a randomised controlled trial
Authors: Mbada Chidozie , Olanipekun Oluwasegun Oladele , Ademoyegun Adekola , Egwu Michael Ogbonnaya , Makinde Moses , Gebrye Tadesse , Sonuga Oluwatobi Ademola , Fatoye Francis 
Published: November 2024

Abstract
Background
Studies comparing the effectiveness of telerehabilitation and spinal manual therapy (SMT) for chronic non-specific low-back pain (NSLBP) are limited. This study aimed to compare the efficacy of the telerehabilitation-based McKenzie therapy (TBMT) and SMT among patients with NSLBP.

Methods
Forty-nine consenting patients randomised into either TBMT (n = 28) or SMT (n = 21) group completed the study. TBMT is a mobile phone-based telerehabilitation involving the ‘McKenzie extension protocol’. SMT is a grade II (10 oscillations) posterior-anterior central vertebral pressure on the offending spinous process. Both interventions were applied thrice weekly for eight weeks, and outcomes were assessed on Pain Intensity (PI), Activity Limitation (AL), Participation Restriction (PR), and Health-related Quality of Life (HRQoL) in the fourth and eighth weeks.

Results
Within-group comparison across baseline, 4th and 8th week indicate that SMT had a significant effect on PI (F = 132.804, p = 0.001), AL (F = 75.984, p = 0.001), PR (F = 99.428, p = 0.001) and for all the scales of SF-12 except for mental health domain (p > 0.05). Similarly, TBMT had a significant effect on PI (F = 243.631; p = 0.001), AL (F = 85.930; p = 0.001), PR (F = 48.425; p = 0.001), and for all the scales except also for mental health domain (p > 0.05). However, there were no significant differences (p > 0.05) in the treatment effects between SMT and TBMT, except for the ‘health perception’ (p = 0.045) scale at week four and the ‘mental health’ scale (p = 0.023) at week eight.

Conclusion
Telerehabilitation-based McKenzie method and SMT are effective in chronic NSLBP, with TBMT leading to significantly higher long-term health perception improvement.

Trial Registration
Pan African Clinical Trial Registry (PACTR202010667228786), Registered 27 October 2020-Retrospectively registered.
Behavioural and neuronal substrates of serious game-based computerised cognitive training in cognitive decline: randomised controlled trial
Authors: Brill Esther , Holfelder Alexa , Falkner Michael , Krebs Christine , Brem Anna-Katharine , Klöppel Stefan 
Published: November 2024

Background
Investigations of computerised cognitive training (CCT) show heterogeneous results in slowing age-related cognitive decline.

Aims
To comprehensively evaluate the effectiveness of serious games-based CCT, integrating control conditions, neurophysiological and blood-based biomarkers, and subjective measures.

Method
In this bi-centric randomised controlled trial with parallel groups, 160 participants (mean age 71.3 years) with cognitive impairment ranging from subjective decline to mild cognitive impairment, were pseudo-randomised to three arms: an intervention group receiving CCT immediately, an active control (watching documentaries) and a waitlist condition, which both started the CCT intervention after the control period. Both active arms entailed a 3-month intervention period comprising a total of 60 at-home sessions (five per week) and weekly on-site group meetings. In the intervention group, this was followed by additional 6 months of CCT, with monthly booster sessions to assess long-term training effects. Behavioural and subjective changes were assessed in 3-month intervals. Biological effects were measured by amyloid blood markers and magnetic resonance imaging obtained before and after training.

Results
Adherence to the training protocol was consistently high across groups and time points (4.87 sessions per week). Domain-specific cognitive scores showed no significant interaction between groups and time points. Significant cognitive and subjective improvements were observed after long-term training. Voxel-based morphometry revealed no significant changes in grey matter volume following CCT, nor did amyloid levels moderate its effectiveness.

Conclusions
Our study demonstrates no benefits of 3 months of CCT on cognitive or biological outcomes. However, positive effects were observed subjectively and after long-term CCT, warranting the inclusion of CCT in multicomponent interventions.
Neoadjuvant Atezolizumab in Patients With Surgically Resectable Advanced Cutaneous Squamous Cell Carcinoma
Authors: Divi Vasu , Aasi Sumaira , Khan Saad A. , Lam Lily , Martinez Ramirez Luis , Sunwoo John B. , Rahman Mobeen , Ma Yifei , Kurzymski Monika , Baik Fred M. , Chen Michelle , Finegersh Andrey , Hirotsu Kelsey E. , Holsinger F. Chris , Kibbi Nour , Sirjani Davud , Bedi Nikita , Pinto Harlan , Colevas A. Dimitrios 
Published: November 2024

PURPOSE
To evaluate the feasibility of administering three doses of neoadjuvant atezolizumab before curative surgical resection in patients with advanced cutaneous squamous cell carcinoma (cSCC).

PATIENTS AND METHODS
This single-arm phase II trial included patients with cSCC of the head and neck with stage III or IV disease, or stage II lesions for which standard therapy would incur an unacceptable morbidity. Patients received up to three doses of atezolizumab at a fixed dose of 1,200 mg every 21 days before undergoing surgical resection. The primary end point was the percentage of patients able to complete three doses of therapy and be eligible for surgical resection without discontinuation due to toxicity or progression. Secondary end points included unconfirmed RECIST 1.1 response rate, pathological response rate (major and complete pathological response), and safety and tolerability of atezolizumab.

RESULTS
Twenty patients were enrolled and treated. Sixteen (80%) of 20 patients completed three doses of atezolizumab, and all patients were eligible for surgical resection. A pathological complete response was seen in seven (35%; 95% CI, 15.4 to 59.2) patients, and a major pathological response (<10% viable tumor) was seen in four (20%; 95% CI, 5.7 to 43.7) patients. RECIST responses were seen in eight (40%; 95% CI, 19.1 to 64.0) patients, and one (5%) patient progressed. Grade 3 or higher adverse events were seen in one (5%) patient who developed pneumonitis after the first dose of atezolizumab.

CONCLUSION
Neoadjuvant atezolizumab is feasible and well tolerated in patients with advanced cSCC and results in a high rate of major and complete pathological responses.
Ungrading
Authors: Stommel Jesse 
Published: November 2024

Abstract
The word ungrading means raising an eyebrow at grades as a systemic practice, distinct from simply not grading. The word is a present participle, an ongoing process, not a static set of practices. Too many approaches to grades treat students as if they are interchangeable and fail to recognize their complexity. Educational institutions need to start by rewriting policies and imagining new ways forward for the most marginalized students. This essay examines contemporary approaches to assessment; considers the history of grades; interrogates the bias inherent in standardized systems; and explores methods and approaches for designing assessments that push back against traditional notions of grading.
Enhancing Ungrading
Authors: Zimmerman Griffin Xander 
Published: November 2024

Abstract
While ungrading is gaining traction within higher education, many teachers still struggle with applying ungrading systems successfully in their classrooms. This article is designed to bridge the gap between an ideological commitment to ungrading and pedagogical praxis by focusing on the ideologies that are embedded in ungrading systems. This represents an important shift from the focus on tools or methods to a focus on the habits of mind necessary to adapt ungrading to individual classrooms. This article claims that one of the key challenges to implementing ungrading stems from attempting to tack alternative assessment onto existing pedagogical frameworks. By utilizing a disability justice approach, the author offers a praxis-based primer to support educators in shifting their habits of mind to facilitate ungrading. First, the article asks readers to examine their ideological assumptions surrounding classrooms and demonstrates how these ideologies influence and interact with ungrading principles. Next, the article explores how a disability justice framework provides important contextualizing guidance to enacting ungrading ideologies. Finally, it synthesizes key lessons from disability justice theory and localizes them in examples of classroom praxis, demonstrating how a reorientation away from a “best practices” approach to ungrading facilitates successful implementation in the classroom.