bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of maternal dietary nitrate supplementation during the perinatal period on piglet survival, body weight, and litter uniformity
Authors: van den Bosch Moniek , Wijnen Jan , van de Linde Irene B , van Wesel Ad A M , Melchior Delphine , Kemp Bas , Clouard Caroline , van den Brand Henry 
Published: February 2019

Abstract
The objective of this study was to evaluate effects of different dosages of dietary nitrate supplementation to sows from d 108 of gestation until d 5 of lactation on reproductive performance of sows and piglet performance from birth until weaning. Dietary nitrate supplementation leads to nitric oxide (NO) formation that can potentially increase blood flow to the fetuses (by the vasodilative effect of NO), leading to a decrease in the loss of potential viable piglets in the form of stillbirth and preweaning mortality. Three hundred and five gilts and sows were allocated to one of six diets from d 108 of gestation until d 5 of lactation, containing 0.00% (Control), 0.03%, 0.06%, 0.09%, 0.12%, or 0.15% of dietary nitrate. The source of nitrate used was calcium nitrate double salt. Calcium levels were kept the same among diets by using limestone. Gilts and sows were weighed and backfat was measured at arrival to the farrowing room (d 108 of gestation) and at weaning (d 27 of age). Data included number of piglets born alive, born dead, and weaned, as well as individual piglet weights at d 0, 72 h of age and weaning. Preweaning mortality was determined throughout lactation. Body weight d 0 (P = 0.04) as well as BW at 72 h of age (P &lt; 0.01) increased linearly with increasing dosages of nitrate in the maternal diet. Litter uniformity (SD) at birth was not affected by maternal nitrate supplementation level (P &gt; 0.10), but tended to be higher at 72 h of age in the control treatment than in all nitrate-supplemented treatments (P = 0.07), and SD decreased linearly (increased uniformity) at weaning with increasing dosages of nitrate (P = 0.05). BW at weaning (P &gt; 0.05) and average daily gain of piglets during lactation (P &gt; 0.05) were not affected by maternal nitrate supplementation. A tendency for a quadratic effect (P = 0.10) of the dosage of maternal dietary nitrate was found on preweaning mortality of piglets with the lowest level of mortality found at 0.09% to 0.12% of maternal nitrate supplementation. We conclude that the use of nitrate in the maternal diet of sows during the perinatal period might stimulate preweaning piglet vitality. Exact mode of action and optimal dose of nitrate still need to be elucidated.
Integration of Contraceptive Services Into Anticoagulation Management Services Improves Access to Long-acting Reversible Contraception
Authors: Bernard Caitlin , Pekny Chelsea , Omukagah Christabell O. , Bernard Christian O. , Manji Imran , Pastakia Sonak D. , Christoffersen-Deb Astrid 
Published: February 2019

(Abstracted from Contraception 2018;98(6):486–491)
Increasing access to contraception in women of reproductive age is a cost-effective strategy to reduce maternal morbidity and mortality, especially in women with chronic diseases. Approximately 28% of global maternal mortality is nonobstetric in nature, and 70% of these cases are due to preexisting medical conditions exacerbated by pregnancy.
Neonatal Outcomes of Elective Early-term Births After Demonstrated Fetal Lung Maturity
Authors: Tita Alan T. N. , Jablonski Kathleen A. , Bailit Jennifer L. , Grobman William A. , Wapner Ronald J. , Reddy Uma M. , Varner Michael W. , Thorp John M. , Leveno Kenneth J. , Caritis Steve N. , Iams Jay D. , Saade George , Sorokin Yoram , Rouse Dwight J. , Blackwell Sean C. , Tolosa Jorge E. 
Published: February 2019

(Abstracted from Am J Obstet Gynecol 2018;219(3):296.e1–296.e8)
Studies of early-term birth after demonstrated fetal lung maturity show that respiratory and other outcomes are worse with early-term birth (37 0/7–38 6/7 weeks) even after demonstrated fetal lung maturity when compared with full-term birth (39 0/7–40 6/7 weeks). However, these studies included medically indicated births and are therefore potentially limited by confounding by the indication for delivery.
Pain Catastrophizing and Function In Individuals With Chronic Musculoskeletal Pain
Authors: Martinez-Calderon Javier , Jensen Mark P. , Morales-Asencio Jose M. , Luque-Suarez Alejandro 
Published: February 2019

Objectives:
Pain catastrophizing (PC) is the most consistent psychosocial factor predicting of adjustment to chronic pain and may contribute to the development and long-term maintenance of chronic pain. The aim of this review was systematically review and critically appraise the concurrent and longitudinal associations between PC and both pain intensity and disability in individuals with chronic musculoskeletal pain (CMP).

Materials and Methods:
An electronic search of PubMed, Scopus, AMED, CINAHL, PsycINFO, and PubPsych databases, as well as gray literature, was undertaken from inception until September 2018. Cross-sectional and longitudinal studies reporting on the associations between measures of PC, pain intensity, and disability were selected for review.

Results:
A total of 85 observational studies (92% cross-sectional) were included, with a total sample of 13,628 participants with CMP. Very low-quality evidence (based on the GRADE criteria) indicated that higher levels of PC were often, but not always, significantly associated with and prospectively predicted both chronic pain intensity and disability. Heterogeneity was large after conducting multiple meta-analyses.

Discussion:
Despite the very low quality of the available evidence, the general consistency of the findings highlights the potential role that PC may play in delaying recovery from CMP. Research that uses higher quality study designs and procedures would allow for more definitive conclusions regarding the impact of PC on pain and function.
Patient Perceptions of Iliac Crest Bone Grafting in Minimally Invasive Transforaminal Lumbar Interbody Fusion
Authors: Haws Brittany E. , Khechen Benjamin , Patel Dil V. , Cardinal Kaitlyn L. , Guntin Jordan A. , Singh Kern 
Published: February 2019

Study Design:
Retrospective cohort.

Objective:
The objective of this study was to determine patients’ perception of iliac crest bone graft (ICBG) harvesting and donor site pain following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF).

Summary of Background Data:
The incidence of donor site pain has been debated in the literature because of the varying techniques associated with its harvest.

Methods:
Patients undergoing primary, single-level MIS TLIF with ICBG were retrospectively identified. ICBG harvesting was performed using a percutaneous technique with a tubular retractor. A survey was administered to assess if patients could accurately describe which side of their iliac crest they believed was harvested, and if they were experiencing any pain perceived to be originating from the donor site. Patient characteristics were compared using χ2 analysis and independent t test.

Results:
In total, 82 patients were included. The majority of patients had the ICBG harvested from the left iliac crest (97.5%). Approximately half of the patients correctly identified the side of harvest (50.6%). 48.1% of patients reported they were not confident or had guessed on their response. Patients that reported pain from the ICBG were more likely to feel confident or somewhat confident in their harvest site identification (57.9% vs. 46.3%) but less likely to be correct (36.8% vs. 63.4%) than patients without pain. 22 patients (27.8%) correctly identified the side of harvest without guessing. Of these, 11 (13.9%) reported pain.

Conclusions:
Approximately half of patients undergoing MIS TLIF with ICBG are able to correctly identify which side of their iliac crest was harvested. However, the majority of patients reporting pain were unable to correctly identify the side of harvest. This suggests that most patients are likely attributing other sources of pain to their ICBG. Therefore, rates of donor site pain may be over-reported in the current literature with contemporary harvesting techniques.
Correlation of Lower Instrumented Vertebra With Spinal Mobility and Health-related Quality of Life After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis
Authors: Uehara Masashi , Takahashi Jun , Ikegami Shota , Kuraishi Shugo , Futatsugi Toshimasa , Oba Hiroki , Takizawa Takashi , Munakata Ryo , Koseki Michihiko , Kato Hiroyuki 
Published: February 2019

Study Design:
This is a retrospective single-center and single-surgeon study.

Objective:
We investigated the correlation between lower instrumented vertebra (LIV) and spinal mobility 2 years after posterior spinal fusion with pedicle screws for adolescent idiopathic scoliosis (AIS) for optimal LIV selection.

Summary of Background:
Spinal motion can become limited in scoliosis patients who undergo posterior spinal fusion. However, few reports exist on spinal mobility after posterior spinal fusion for AIS and the relationship between the LIV and mobility is unknown. We hypothesize that mobility limitation increases as the LIV is moved inferiorly.

Data:
Of 72 consecutive patients who received posterior spinal fusion using pedicle screws for AIS between October 2009 and August 2015, 66 patients (5 male and 61 female, mean age: 14.9 y) were enrolled.

Materials and Methods:
In total, 66 patients were retrospectively reviewed after stratification according to LIV level. Follow-up rate was 91.7%. Patients were examined for the fingertip-to-floor distance (FFD) before and 2 years after surgery. FFD was measured from the tips of the middle fingers to the floor with the barefoot subject bent maximally forward and the feet together and knees straight. Clinical outcome was assessed using Scoliosis Research Society-22 patient questionnaire (SRS-22r) scores and a visual analog scale for low back pain before and at 2 years postoperatively.

Results:
The median number of fused vertebrae was 9 (range: 4–15). The LIV was T11–12 in 15 patients, L1 in 11 patients, L2 in 10 patients, and L3 in 30 patients. The median decrease in FFD according to LIV at 2 years after surgery was T11–12: 0 cm, L1: 0 cm, L2: 5.5 cm, and L3: 10 cm. Thus, limited FFD became significantly more severe as the LIV was moved downwards (P<0.01). There were no significant correlations between limited FFD and SRS-22r or pain visual analog scale scores at 2 years postoperatively.

Conclusions:
FFD became significantly more restricted as the LIV was moved inferiorly but clinical results appeared unaffected by limited FFD.
Replacement or repair of terrible triad of the elbow
Authors: Chen Hongwei , Shao Yinchu , Li Shaobo 
Published: February 2019

Abstract

Background:
Surgical treatment for terrible triad injuries remains a challenging clinical problem, and controversy exists of whether it is better to repair or replace the radial head. The objective of this systematic review was to evaluate the clinical outcomes of repair and arthroplasty replacement of the radial head in patients with terrible triad injury.

Methods:
Medline, Cochrane Library, EMBASE, and Google Scholar were searched up to July 30, 2018 to identify the relevant studies, which included patients who had received treatments of the terrible triad of the elbow and also had reported with the quantitative outcomes. Outcomes of interest were functional outcomes.

Results:
Four studies with a total of 115 patients were included in the systematic review. Most patients were type II or III radial head fractures based on the Mason classification systems. Fifty-one patients received radial head repair surgery and 64 underwent replacement. Two studies had indicated that patients in the replacement group were significantly associated with better treatment outcome assessed by DASH (Disabilities of the Arm, Shoulder and Hand) and MEPS (Mayo Elbow Performance Score) scores. The meta-analysis indicated that patients with the arthroplasty replacement were associated with significantly better ROM outcomes in flexion, extension, pronation than those with radial head repaired. In addition, patients in the replacement group showed fewer post-surgery complications than those in the repair group.

Conclusions:
Our review had indicated that patients with terrible triad injuries undergo arthroplasty replacement have better clinical outcomes and fewer post-surgery complications than those received the repair surgery. Radial head replacement might be a more effective treatment approach with good clinical outcomes for patients with a terrible triad of the elbow.
Correlation between high-frequency ultrasonography of patients with early rheumatoid arthritis and anti-CCP antibody
Authors: Yang Jie , Shao Qinghe , Wu Jieyan 
Published: February 2019

AbstractObjectives:To study the correlation between high-frequency ultrasonography of patients with early rheumatoid arthritis (RA) and anti-cyclic citrullinated peptide (CCP) antibody.Methods:Two wrists, 1st to 5th metacarpal phalangeal (MCP) and 1st to 5th proximal interphalangeal (PIP) joints of 53 early RA patients treated from October 2015 to October 2017 and 30 healthy subjects were examined by high-frequency ultrasonography. The thicknesses of synovial membrane, sheaths of 1st to 5th extensor tendons, flexor tendons and ulnar wrist extensor tendons were measured. Related pathological changes were observed.Results:RA and control groups had significantly different thicknesses of synovium, extensor and flexor tendon sheaths (P <.001). In RA group, 14.15% of joints had cavity fluid, 5.23% had cartilage destruction, and 2.32% of bone cortices had tendon sheath effusion. The detection rates of tendon sheath effusion and tendon adhesion were 19.81% and 16.30% respectively. Anti-CCP antibody positive group had significantly different DAS28, Health Assessment Questionnaire score and rheumatoid factor positive rate from those of negative group (P <.05). Synovitis, cartilage destruction, bone erosion, tendon sheath effusion, and joint effusion were significantly positively correlated with these values (P <.05). Besides, 8.92% of joints had blood flow signals of thickening synovium, of which joints with signals in the active phase accounted for 4.37%. The resistance index (RI) of synovial artery was (0.58 ± 0.07). However, 0.94% of joints had synovial blood flow signals in the inactive phase, and RI of synovial artery was (0.67 ± 0.03). Anti-CCP antibody positive group was significantly more prone to bone erosion than negative group (P <.05).Conclusions:For patients with early RA, high-frequency ultrasonography was more likely to detect articular cartilage destruction and bone erosion changes when anti-CCP antibody was positive. Combining anti-CCP antibody with ultrasonography can provide valuable evidence for the development of clinical treatment regimens.
Comparison of fit factors among healthcare providers working in the Emergency Department Center before and after training with three types of N95 and higher filter respirators
Authors: Kim Hongjung , Lee Juncheol , Lee Sanghyun , Oh Jaehoon , Kang Boseung , Lim Tae Ho , Kang Hyunggoo 
Published: February 2019

Abstract

Introduction:
N95 or higher filtering respirators have been recommended in healthcare settings, although there is still a risk of infection due to the improper selection and wearing of respirators. We aimed to assess the effects of training with N95 or higher filter respirators on the protection performance of respirators among healthcare providers in the emergency medical center (EMC).

Methods:
This randomized crossover study evaluated 23 healthcare providers. Quantitative fit tests (QNFTs) were performed before and after training using three types of N95 or higher filter respirators (cup-type, fold-type, valve-type). Training was performed by lecture, real-time feedback, and fit check. The primary outcome was the fit factor, and the secondary outcomes were overall fit factor, adequate protection rate, and respiratory preference.

Results:
Fit factors, overall fit factor, and adequate protection rate were higher after training than before training for the 3 types of respirators (all P < .05). For normal breathing, fit factors before and after training were 121 (10–185) vs 192 (161–200) for cup-type, 200 (39–200) vs 200 (200–200) for fold-type, and 85 (18–157) vs 173 (117–200) for valve-type. For normal breathing, the adequate protection rates before and after training were 62 (0–100) vs 100 (90–100) for cup-type, 100 (0–100) vs 100 (100–100) for fold-type, and 19 (0–100) vs 100 (44–100) for valve-type (all P < .05). The most preferred respirator type was the valve-type (10 persons, 45.5%).

Conclusions:
Training on wearing an N95 or higher respirator improved the protection performance of respirators among healthcare providers working in the EMC. The selection of proper respirators and training would be beneficial to the safety of healthcare providers.
Dental caries among childhood cancer survivors
Authors: Proc Patrycja , Szczepańska Joanna , Herud Anna , Zubowska Małgorzata , Fendler Wojciech , Młynarski Wojciech 
Published: February 2019

Abstract
One of many possible complications of cancer therapy in children is enamel demineralization and such changes in the ion content of dental hard tissues may increase susceptibility to caries. The study aims to assess the prevalence of dental caries among childhood cancer survivors.
A cross-sectional study was conducted on 225 children aged between 4 and 18 years, including 75 cancer patients and 150 sex- and age-matched controls. The cancer survivors were recruited from single pediatric oncology center. The control group was formed from students of randomly selected kindergartens and schools. Dental investigation was held between July 2013 and January 2016, approximately 5 years after the cessation of anticancer treatment (range: 6–155 months). The occurrence of dental caries was assessed with DMF/dmf index (showing the mean number of decayed, missing and filled permanent/deciduous teeth). Univariate statistical approach was performed and P-values < .05 were considered as statistically significant.
The frequency of dental caries was comparable in both groups (85.4% vs 84%). However, the DMF index was higher in cancer patients than in controls: the median and interquartile ranges were 2 (0–4) vs 0 (0–2); P < .01. This correlates with duration of anticancer therapy (r = 0.26; P < .05). Moreover, children who had radiotherapy of the head and neck regions had significantly higher DMF scores than the ones who did not: 4.5 (1–6) vs 2 (0–4); P < .05. Socioeconomic and education status within family also has a significant impact on DMF scores in the cancer group. In conclusion, cancer patients, particularly those with a poor social background, should receive professional dental care as their caries process is more active than that of healthy peers.
Effect of an interactive voice response system on self-management in kidney transplant recipients
Authors: Ganjali Raheleh , Taherzadeh Zhila , Ghorban Sabbagh Mahin , Nazemiyan Fatemeh , Mamdouhi Fereshteh , Tabesh Hamed , Badiee Aval Shapour , Golmakani Reza , Mostafavi Sayyed Mostafa , Eslami Saeid 
Published: February 2019

Abstract

Introduction:
Adherence to a complex and ongoing set of therapeutic recommendations significantly determines short and long-term outcomes after kidney transplantation (KT). Interactive voice response system (IVRS) is a novel phone-based platform which is potentially useful to deliver health behavior interventions.

Objective:
The aims of the study is to describe the development of a theory-driven and educational IVRS investigate the effect of an IVRS on the self-management outcomes in KT recipients as compared with the control group.

Methods:
This study has been designed as a randomized, 2 parallel groups controlled trial. The KT recipients’ older than18 years of age with access to a cellphone will be included. A total of 120 patients will be randomly assigned to the control and intervention groups. The participants in the intervention group will receive completely automatic calls in 3 categories: educational, medication adherence, and reminders by the IVRS, whereas those in the control group will receive usual care. The follow up will be performed within 6 months. The primary outcome will be the medication adherence while patients’ transplant knowledge, health-related quality of life, and rehospitalization rates will be considered as secondary outcomes.

Results:
Thus far, recruitment of participants has not been completed and results will be published in 2019.

Discussion:
The IVRS is potentially useful to help KT recipients improve the self-management outcomes. The hypothesis is using an IVRS intervention makes a significant difference between basel assessment of adherence to immunosuppressive medications scale, 12-item short form survey, second version, kidney transplant understanding tool baseline scores, and those obtained at the end of study.

Trial registration number:
This trial is registered with the Iran Trial Registrar under registration number IRCT20180124038492N1 and registration date 30 January 2018. https://irct.ir/trial/29215
Headache due to spinothalamic tract injury in patients with mild traumatic brain injury
Authors: Jang Sung Ho , Seo You Sung 
Published: February 2019

Abstract

Rationale:
Headache is the most common physical complaint reported by the following traumatic brain injury (TBI). Several studies using diffusion tensor tractography (DTT) have demonstrated that injury of the spinothalamic tract (STT) is a pathogenetic mechanism of central pain following TBI. However, no study of headache due to injury of the STT has been reported.

Patient concerns:
Patient 1 was a 52-year-old female who suffered head trauma resulting from an in-car traffic crash. While sitting in a passenger seat in a moving vehicle, another vehicle suddenly hit the car from the right side. Her head hit the door and she suffered a flexion-hyperextension-rotation injury. She began to feel headaches in both fronto-parieto-occipital areas approximately 2 weeks after the crash. The characteristics and severity of pain were as follows: constant tingling and intermittent stabbing pain without allodynia or hyperalgesia (visual analogue scale score: 7). Patient 2 was a 50-year-old male who suffered head trauma from a flexion-hyperextension injury that occurred after being hit from behind by a vehicle while driving his car. He began to feel headache in both fronto-parieto-occipital areas the day after the crash: constant tingling pain without allodynia or hyperalgesia (visual analogue scale score: 6).

Diagnoses:
The patient 1 was diagnosed as mild TBI due to head flexion-hyperextension-rotation injury. The patient 2 was diagnosed as mild TBI due to head flexion-hyperextension injury.

Interventions:
Clinical assessment and DTT were performed at 5 months (patient 1) and 10 months (patient 2) after the initial injury.

Outcomes:
On DTTs of patient 1 and 2, the STTs showed narrowing in both hemispheres. In addition, discontinuations at the subcortical white matter were observed in both hemispheres in patient 2.

Lessons:
Headache due to injury of the STT was diagnosed in patients with mild TBI. Precise diagnosis of central pain from other types of pain is clinically important because the management of central pain is quite different from those for other types of pain. Our results suggest that headache might be ascribed to the injury of the STT in patients with mild TBI. Therefore, we recommend evaluation of the STT using DTT in patients with mild TBI who complain of headache having the characteristics of neuropathic pain.