bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving CO2/CH4 and CO2/N2 adsorptive selectivity of Cu‐BTC and MOF‐derived nanoporous carbon by modification with nitrogen‐containing groups
Authors: Salehi Samira , Anbia Mansoor , Razavi Fatemeh 
Published: July 2019

ABSTRACTFor the first time in this study compared the adsorption capacity and selectivity of carbon dioxide (CO2), methane (CH4), and nitrogen (N2) on amine‐modified copper(II) benzene‐1,3,5‐tricarboxylate (Cu‐BTC) and metal organic framework‐derived nanoporous carbon (MOF/NPC) by employing a volumetric measurement. The MOF/NPC is synthesized via direct carbonization of the Cu‐BTC as a template without any carbon precursor at 900°C under N2 atmosphere and shows easy synthesis, large surface area, high excellent thermal and chemical stability as well as high resistance to moisture. All the prepared materials are characterized by nitrogen adsorption/desorption, Fourier transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD) and scanning electron microscopy (SEM), energy dispersive X‐ray spectroscopy (EDX), and thermogravimetric analysis (TGA). The porous supports could be effectively improved for CO2 adsorption with amine groups due to their high affinity toward CO2. CO2 adsorption capacity for MOF/NPC is 7.50 mmol g−1 when MOF/NPC is modified with the amine, CO2 adsorption capacity is increased (from 7.50 to 11.40 mmol g−1) at 298 K and 10 bar.
Interaction of a Barium‐Calcium‐Silicate Glass Composite Sealant with Sanergy HT 441
Authors: Gross‐Barsnick S.‐M. , Margaritis N. , de Haart U. , Huczkowski P. , Quadakkers W. J. 
Published: July 2019

AbstractThe interaction between Sandvik's coated Sanergy HT 441 (EN 1.4509) with a cerium‐cobalt layer as chromium evaporation barrier and a glass‐ceramic composite sealant on the basis of BaO‐CaO‐SiO2 was investigated in this study. The oxidation behavior of the steel was analyzed by long‐term weight change measurements of strip samples at 800 °C for 10,000 h followed by scanning electron microscopy on cross‐sectioned samples. A double oxide layer was formed consisting of chromia close to the steel and a layer with 18 wt.% Cr, 11% Co, 10% Mn to the air side. The interface of the joined samples had a reaction layer similar to the oxidized steel surface with an additional phase formation consisting of Co/Mn/Fe and low in oxygen facing the glass‐ceramic interface. After these preliminary tests the coated Sanergy HT 441 was integrated as frames into a four layered F10‐stack with 80 cm2 cell area and was tested for 3,500 h at operation temperature of 700 °C and 0.5 A cm−2 constant current mode followed by 20 thermal cycles between 700 and 200 °C. The stack had shown similar performance and gas‐tightness compared to stacks assembled with Crofer 22 APU. The post‐test characterization had shown adhesive fracture patterns when dismantling the stack parts.
The experimental study of biogas production when digesting chicken manure with a biochar additive
Authors: Baltrėnas Pranas , Paliulis Dainius , Kolodynskij Vitalij 
Published: July 2019

AbstractThe research aims to evaluate the output of biogas and the concentration of CH4 and gaseous impurities such as CO2 and H2S in the process of digesting chicken manure without additives (experiment A) and with 10% of biochar additive (by mass of the dry load) (experiment B) under anaerobic and mesophilic conditions. It has been found that the average output of biogas from a particular amount of chicken manure (experiments A and B) obtained in the 45‐day experimental research is similar in both cases and reaches 12.88 l d–1 and 12.36 l d–1, respectively. However, the biochar additive increases CH4 concentration in biogas and reduces the concentration of gaseous impurities (CO2 and H2S) in biogas. The maximum concentration of CH4 in biogas obtained from a load of manure with biochar additive is higher than that in biogas obtained by using a load without a biochar additive, and reaches 72.0% and 68.5%, respectively. The average CO2 concentration, reaching 33.09% and 47.5%, respectively, in biogas obtained from the load with 10% of biochar additive is lower than that in biogas obtained from the manure load without an additive. The average concentration of H2S in the biogas obtained in experiment B is lower than that in experiment A and reaches 95.9 mg m–3 and 195.5 mg m–3, respectively. The biochar additive adsorbs gaseous impurities (CO2 and H2S) from biogas without adsorbing CH4. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd.
Comparison of weight gain between levonorgestrel and etonogestrel implants after 12 months of insertion
Authors: Okunola Temitope O. , Bola‐Oyebamiji Sekinat B. , Sowemimo Oluwaseun 
Published: July 2019

AbstractObjectiveTo compare weight gain between women using etonogestrel implants and those using levonorgestrel implants 12 months after insertion.MethodsA multicenter prospective cohort study was performed on women recruited from family planning clinics between July 2016 and August 2017. The main study outcome was mean weight gain after 12 months of insertion of the implants.ResultsThe present study included 150 women (age range 18–45 years) using levonorgestrel implants and 167 women using etonogestrel implants. The women recruited had been using implants for less than 6 months; implants had been inserted 6–12 months after their last pregnancy. Participants were followed up until 12 months after insertion through telephone conversations. Baseline parameters were obtained from the clinic records and weight was measured within 6 weeks of the 12‐month anniversary of insertion of the implants. Data were analyzed with SPSS version 23. Weight gain in the levonorgestrel group was significantly higher than in the etonogestrel group (3.16 ± 4.08 vs 0.77 ± 3.76, P = 0.013; relative risk 1.69, 95% confidence interval 1.46–1.96). There were no differences in the occurrence of menstrual irregularities and client satisfaction.ConclusionWomen using levonorgestrel implants were more likely to gain weight compared to those using etonogestrel implants after 12 months of insertion.
Association of caspase 8 promoter variants and haplotypes with the risk of breast cancer and its molecular profile in an Iranian population: A case‐control study
Authors: Bagherabad Matineh Barati , Afzaljavan Fahimeh , Vahednia Elham , Rivandi Mahdi , Vakili Fatemeh , Sadr Susan Sadat Hashemi , Shandiz Fatemeh Homaei , Pasdar Alireza 
Published: July 2019

AbstractCaspase 8 (CASP8) gene plays a key role in the regulation of apoptotic cell death. Expression variation in this gene has been associated with the risk of breast cancer. The aim of this study was to investigate the association of rs3834129 and rs3769821, as functional variants, and their haplotypes with molecular profile as well as the risk of breast cancer in an Iranian population. A case‐control study was conducted on 812 participants including 293 breast cancer patients and 519 healthy controls. Genotyping was performed by polymerase chain reaction–based methods. Statistical analysis was performed using SPSS Ver16. The association between polymorphisms and haplotypes with the risk of breast cancer was estimated by calculating odds ratios (OR) and chi‐square (χ2) tests. In comparison with ins allele (I) of rs3834129, carriers of del allele (D) showed a lower risk of breast cancer (OR, 0.65; 95% confidence interval [CI], 0.49‐0.87; P = 0.004). The multivariate logistic regression model indicated DD genotype as an independent factor for a decreased risk of breast cancer in our population (OR, 0.18; 95% CI, 0.06‐0.58; P = 0.004). Also, the C allele of rs3769821 was associated with a 43% increased risk of breast cancer (P = 0.005); however, after adjustment for confounding factors, no association with rs3769821 and breast cancer was observed. In addition, D‐T haplotype and diplotype presented protective effects (P < 0.05). Our results indicate that genetic variations in the promoter region of CASP8 gene, especially rs3834129, may serve as a genetic risk factor for breast cancer in an Iranian population.
Circulating microRNAs as potential diagnostic biomarkers and therapeutic targets in prostate cancer: Current status and future perspectives
Authors: Movahedpour Ahmad , Ahmadi Nahid , Ghasemi Younes , Savardashtaki Amir , Shabaninejad Zahra 
Published: July 2019

AbstractProstate cancer (PCa) is one of the most common malignancies among men. Despite advancement in technology and medicine over past decades, late diagnosis remains a critical milestone in effective treatment. Therefore, it is necessary to identify novel and reliable biomarkers which are specifically sensitive and specific for prognosis and prediction of clinical outcomes. MicroRNAs (miRNAs) play important roles in posttranslational regulations of genes. Circulating and exosomal miRNAs can be applied as useful diagnostic markers for a different type of malignancies, including PCa. Herein, we summarized various roles of miRNAs (diagnostic, therapeutic, and prognostic) in PCa. Moreover, we highlighted exosomal miRNAs as a new candidate in diagnosis and monitoring response to therapy in patients with PCa.
Exogenous expression of caveolin‐1 is sufficient for hepatic stellate cell activation
Authors: Ilha Mariana , Moraes Ketlen da Silveira , Rohden Francieli , Martins Leo Anderson Meira , Borojevic Radovan , Lenz Guido , Barbé‐Tuana Florencia , Guma Fátima Costa Rodrigues 
Published: July 2019

AbstractCaveolin‐1 (Cav‐1) expression is increased in hepatic stellate cells (HSC) upon liver cirrhosis and it functions as an integral membrane protein of lipid rafts and caveolae that regulates and integrates multiple signals as a platform. This study aimed to evaluate the role of Cav‐1 in HSC. Thus, the effects of exogenous expression of Cav‐1 in GRX cells, a model of activated HSC, were determined. Here, we demonstrated through evaluating well‐known HSC activation markers – such as α‐smooth muscle actin, collagen I, and glial fibrillary acidic protein – that up regulation of Cav‐1 induced GRX to a more activated phenotype. GRXEGFP‐Cav1 presented an increased migration, an altered adhesion pattern, a reorganization f‐actin cytoskeleton, an arrested cell cycle, a modified cellular ultrastructure, and a raised endocytic flux. Based on this, GRX
EGFP‐Cav1 represents a new cellular model that can be an important tool for understanding of events related to HSC activation. Furthermore, our results reinforce the role of Cav‐1 as a molecular marker of HSC activation.
Computational aided mechanistic understanding of Camellia sinensis bioactive compounds against co‐chaperone p23 as potential anticancer agent
Authors: Bharadwaj Shiv , Lee Kyung Eun , Dwivedi Vivek Dhar , Yadava Umesh , Kang Sang Gu 
Published: July 2019

AbstractCo‐chaperon p23 has been well established as molecular chaperon for the heat shock protein 90 (Hsp90) that further leads to immorality in cancer cells by providing defense against Hsp90 inhibitors, and as stimulating agent for generating overexpressed antiapoptotic proteins, that is, Hsp70 and Hsp27. The natural compounds such as catechins from Camellia sinensis (green tea) are also well known for inhibition activity against various cancer. However, molecular interaction profile and potential lead bioactive compounds against co‐chaperon p23 from green tea are not yet reported. To this context, we study the various secondary metabolites of green tea against co‐chaperon p23 using structure‐based virtual screening from Traditional Chinese Medicine (TCM) database. Following 26 compounds were obtained from TCM database and further studied for extra precision molecular docking that showed binding score between −10.221 and −2.276 kcal/mol with co‐chaperon p23. However, relative docking score to known inhibitors, that is, ailanthone (−4.54 kcal/mol) and gedunin ( 3.60 kcal/mol) along with ADME profile analysis concluded epicatechin (−7.013 kcal/mol) and cis‐theaspirone (−4.495 kcal/mol) as potential lead inhibitors from green tea against co‐chaperone p23. Furthermore, molecular dynamics simulation and molecular mechanics generalized born surface area calculations validated that epicatechin and cis‐theaspirone have significantly occupied the active region of co‐chaperone p23 by hydrogen and hydrophobic interactions with various residues including most substantial amino acids, that is, Thr90, Ala94, and Lys95. Hence, these results supported the fact that green tea contained potential compounds with an ability to inhibit the cancer by disrupting the co‐chaperon p23 activity.
Long non‐coding RNA THRIL predicts increased acute respiratory distress syndrome risk and positively correlates with disease severity, inflammation, and mortality in sepsis patients
Authors: Wang Yan'e , Fu Xiaoxing , Yu Bo , Ai Fen 
Published: July 2019

AbstractBackgroundThis present study aimed to investigate the correlation of long non‐coding RNA THRIL (lnc‐THRIL) with acute respiratory distress syndrome (ARDS) risk, disease severity, inflammation, and mortality in sepsis patients.MethodsA total of 109 sepsis patients admitted to intensive care units were consecutively recruited, and their blood samples were collected. After admission, patients were supervised and screened daily to identify the occurrence of ARDS. Clinical characteristics, routine laboratory testing, and disease severity were recorded, and all enrolled patients were followed up until death in the hospital or discharge for mortality records. Lnc‐THRIL was detected by quantitative polymerase chain reaction, and inflammatory cytokine levels were measured by human enzyme‐linked immunoassay.ResultsA total of 32 (29.4%) sepsis patients occurred ARDS and 77 (71.6%) did not. Lnc‐THRIL was upregulated in ARDS group compared with non‐ARDS group, and it had good value in distinguishing ARDS from non‐ARDS in sepsis patients (AUC: 0.706; 95%CI: 0.602‐0.809). Besides, lnc‐THRIL, smoke, and chronic obstructive pulmonary disease independently predicted increased risk of ARDS. As for disease severity, lnc‐THRIL positively correlated with APACHE II score and SOFA score in sepsis patients. Regarding inflammation, lnc‐THRIL was positively associated with CRP, PCT, TNF‐α, and IL‐1β levels in sepsis patients. Additionally, the mortality rate was 30.2%, and lnc‐THRIL was upregulated in non‐survivors compared with survivors, presenting a good value (AUC: 0.780; 95%CI: 0.683‐0.876) in predicting mortality in sepsis patients.ConclusionLnc‐THRIL predicts increased risk of ARDS and positively correlates with disease severity, inflammation, and mortality in sepsis patients.
Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation
Authors: Yang Jun-Qi , Kalim Khalid W , Li Yuan , Zheng Yi , Guo Fukun 
Published: July 2019

Abstract
Asthma is a heterogeneous chronic airway inflammation in which Th2 and Th17 cells are key players in its pathogenesis. We have reported that RhoA of Rho GTPases orchestrated glycolysis for Th2 cell differentiation and allergic airway inflammation by the use of a conditional RhoA-deficient mouse line. However, the role of RhoA in Th17 cells remains to be elucidated. In this study, we investigated the effects of RhoA deficiency on Th17 cells in the context of ex vivo cell culture systems and an in vivo house dust mites (HDM)-induced allergic airway inflammation. We found that RhoA deficiency inhibited Th17 differentiation and effector cytokine secretion, which was associated with the downregulations of Stat3 and Rorγt, key Th17 transcription factors. Furthermore, loss of RhoA markedly suppressed Th17 and neutrophil-involved airway inflammation induced by HDM in mice. The infiltrating inflammatory cells in the lungs and bronchoalveolar lavage (BAL) fluids were dramatically reduced in conditional RhoA-deficient mice. Th17 as well as Th2 effector cytokines were suppressed in the airways at both protein and mRNA levels. Interestingly, Y16, a specific RhoA inhibitor, was able to recapitulate the most phenotypes of RhoA genetic deletion in Th17 differentiation and allergic airway inflammation. Our data demonstrate that RhoA is a key regulator of Th17 cell differentiation and function. RhoA might serve as a potential novel therapeutic target for asthma and other inflammatory disorders.
A high‐performance CMOS four‐stage amplifier
Authors: Soltani Zanjani Masoud , Asiyabi Tayebeh , Biabanifard Sadegh 
Published: July 2019

AbstractIn this paper, we theoretically propose and mathematically describe an effective four‐stage structure in Complementary metal‐oxide‐semiconductor (CMOS) technology based on differential block feedback. The special architecture of frequency compensation network improves frequency response with very small value of compensation capacitor, which results in low die area occupation. The presented novel and simple four‐stage structure is frequency compensated just via single Miller capacitor and a differential block. Symbolical transfer function is calculated, and circuit dynamics are introduced. To well explain theoretical description, the proposed configuration at circuit level is simulated using Taiwan Semiconductor Manufacturing Company Limited (TSMC) 0.18‐μm CMOS technology and HSPICE circuit simulator. The proposed configuration and corresponding circuit benefits from circuit simplicity and low die‐area occupation. The frequency compensation network forms two Miller loops with negative loop gains. Feedback paths are amplified via differential block while feedforward paths are attenuated, leads to improving frequency response compare with conventional structures. Ample simulation results are in good agreement with theoretical description. Leveraging the concept and method proposed four‐stage amplifier exhibits 170 dB, 8.12 MHz, and 90° as direct current (DC) gain, Gain‐BandWidth Product (GBW), and Pase Margin (PM), respectively. The supply voltage is set to 1.8 V, while the simulated circuit consumes 380 μW.
Translating striatal activity from brain slice to whole animal neurophysiology: A guide for neuroscience research integrating diverse levels of analysis
Authors: Cromwell Howard Casey 
Published: July 2019

AbstractAn important goal of this review is highlighting research in neuroscience as examples of multilevel functional and anatomical analyses addressing basic science issues and applying results to the understanding of diverse disorders. The research of Dr. Michael Levine, a leader in neuroscience, exemplifies this approach by uncovering fundamental properties of basal ganglia function and translating these findings to clinical applications. The review focuses on neurophysiological research connecting results from in vitro and in vivo recordings. A second goal is to utilize these research connections to produce novel, accurate descriptions for corticostriatal processing involved in varied, complex functions. Medium spiny neurons in striatum act as integrators combining input with baseline activity creating motivational “events.” Basic research on corticostriatal synapses is described and links developed to issues with clinical relevance such as inhibitory gating, self‐injurious behavior, and relative reward valuation. Work is highlighted on dopamine–glutamate interactions. Individual medium spiny neurons express both D1 and D2 receptors and encode information in a bivalent manner depending upon the mix of receptors involved. Current work on neurophysiology of reward processing has taken advantage of these basic approaches at the cellular and molecular levels. Future directions in studying physiology of reward processing and action sequencing could profit by incorporating the divergent ways dopamine modulates incoming neurochemical signals. Primary investigators leading research teams should mirror Mike Levine's efforts in “climbing the mountain” of scientific inquiry by performing analyses at different levels of inquiry, integrating the findings, and building comprehensive answers to problems unsolvable without this bold approach.
Thermal conditions during neonatal anoxia affect the endogenous level of brain‐derived neurotrophic factor
Authors: Kletkiewicz Hanna , Maliszewska Justyna , Jaworski Krzysztof , Jermacz Łukasz , Smoliński Dariusz J. , Rogalska Justyna 
Published: July 2019

AbstractAnoxia during delivery is a complication that can disturb infant brain development leading to various types of neurological disorders. Our studies have shown that increased body temperature of newborn rats of both sexes intensifies the postanoxic oxidative stress and prevents triggering the endogenous adaptive response such as HIF‐1α activation. Currently, brain‐derived neurotrophic factor‐BDNF is considered to be a modulator of neuronal plasticity. In the developing brain, mature BDNF and its precursor exhibit prosurvival action through the TrkB receptor and proapoptotic functions binding to p75NTR, respectively. The aim of our experiments was to check the effects of body temperature on the postanoxic level of BDNF and on the expression of its receptors as well as on the marker of apoptosis—caspase‐3 in the rat brain. Two‐day‐old Wistar Han rats (male/female ratio, 1:1) were exposed to anoxia in 100% nitrogen atmosphere for 10 min in different thermal conditions, which allowed them to regulate their rectal temperature at the following levels: normothermic—33°C; hyperthermic—37°C; and extremely hyperthermic—39°C. Thermal conditions during neonatal anoxia affected the level of proBDNF, BDNF as well as their receptors and caspase‐3 in the forebrain. The increased BDNF protein level followed by decreased caspase‐3 protein level was probably dependent on body temperature under anoxic conditions and was observed only in rats maintaining decreased body temperature. The positive effect of BDNF was not observed under hyperthermic conditions. Moreover, BDNF level changes correlated with body temperature probably affected the learning and spatial memory in juvenile rats.
Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model
Authors: Zakhary George , Sherchan Prativa , Li Qian , Tang Jiping , Zhang John H. 
Published: July 2019

AbstractNeurosurgical procedures result in surgically induced brain injury (SBI) that causes postoperative complications including brain edema and neuronal apoptosis in the surrounding brain tissue. SBI leads to the release of cytokines that indirectly cause the stimulation of kynurenine 3‐monooxygenase (KMO) and the release of neurotoxic quinolinic acid (QUIN). This study tested a KMO inhibitor, RO 61‐8048, to prevent postoperative brain edema and consequent neuronal apoptosis in an in vivo model of SBI. A rodent model of SBI was utilized which involves partial resection of the right frontal lobe. A total of 127 Sprague‐Dawley male rats (weight 275–325 g) were randomly divided into the following groups: Sham surgical group, SBI, SBI + DMSO, SBI + RO 61‐8048 (10 mg/kg), SBI + RO 61‐8048 (40 mg/kg), and SBI + RO 61‐8048 (40 mg/kg) + KAT II inhibitor PF‐04859989 (5 mg/kg). RO 61‐8048 was administered by intraperitoneal injection after SBI. Postoperative assessment at different time points included brain water content (brain edema), neurological scoring, and western blot. SBI increased brain water content (ipsilateral frontal lobe), decreased neurological function, and increased apoptotic markers compared with sham animals. Treatment with RO 61‐8048 (40 mg/kg) reduced brain water content and improved long‐term neurological function after SBI. RO 61‐8048 increased the expression of kynurenic acid while reducing QUIN and apoptotic markers in the surrounding brain tissue after SBI. These neuroprotective effects were reversed by PF‐04859989. This study suggests KMO inhibition via RO 61‐8048 as a potential postoperative therapy following neurosurgical procedures.