bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved Outcomes of Enhanced Recovery After Surgery (ERAS) Protocol for Radical Cystectomy with Addition of a Multidisciplinary Care Process in a US Comprehensive Cancer Care Center
Authors: Patel Sephalie Y. , Garcia Getting Rosemarie E. , Alford Brandon , Hussein Karim , Schaible Braydon J. , Boulware David , Lee Jae K. , Gilbert Scott M. , Powsang Julio M. , Sexton Wade J. , Spiess Philippe E. , Poch Michael A. 
Published: May 2018

AbstractIntroductionAlthough enhanced recovery after surgery (ERAS) components include both anesthesia and surgical care processes, it is unclear whether a multidisciplinary approach to implementing ERAS care processes improves clinical outcomes. The addition of multidisciplinary care with anesthesiology‐related components to an existing ERAS protocol for radical cystectomy at a US comprehensive cancer center provided an opportunity to compare short‐ and long‐term outcomes.MethodsWe retrospectively compared the outcomes of 116 consecutive patients who underwent cystectomy after implementation of a multidisciplinary ERAS protocol with those of a historical control group of 143 consecutive patients who had been treated with a surgical ERAS protocol. Length of stay, return of bowel function, rate of blood transfusion, nausea, pain, and readmission rates were examined.ResultsImplementation of a multidisciplinary ERAS protocol was associated with better postsurgical symptom control, as indicated by lower rates of patient‐reported nausea (P < .05). Multivariate Poisson regression analysis showed a decrease in estimated intraoperative transfusions (P ≤ .001) after adjusting for the effects of potential confounding variables. There were no statistically significant differences noted in length of stay, return of bowel function, 30‐ and 90‐day complications, or readmissions.ConclusionThis is the first study to investigate the effects of adding anesthesia ERAS components to an existing surgical ERAS protocol for radical cystectomy. We found that with the addition of anesthesia‐related interventions, there was a decrease in transfusions and nausea.
Molecular diversity of Scutellonema
bradys populations from Benin, based on ITS1 rDNA and COI
mtDNA
Authors: Etchiha Afoha Sètondji Alban Paterne , Affokpon Antoine , Waeyenberge Lieven , de Sutter Nancy , Agbangla Clément , Dansi Alexandre , Coyne Daniel L. , Viaene Nicole 
Published: May 2018

Abstract
In Benin, yam production continues to face numerous production
constraints, including yield and quality reduction by Scutellonema bradys. Implementation of efficient management
techniques against this pest requires an improved understanding, including at the
molecular level, of the pest. The current study aimed at identifying the Scutellonema spp. associated with yam in Benin and
investigating the phylogenetic relationships between populations. Nematodes of the
genus Scutellonema were obtained from tubers
exhibiting external dry rot symptoms. DNA was extracted from nematodes belonging to
138 populations collected from 49 fields from 29 villages. For 51 of these
populations, both the ITS1 and COI regions could be amplified via PCR, sequenced, compared with available sequences
in the NCBI database and were identified as S.
bradys. Maximum likelihood was used to construct 60% consensus
phylogenetic trees based on 51 sequences. This phylogenetic analysis did not reveal
any genetic separation between populations by cultivar, village, cropping system nor
by agroecological zone. Neither could any subgroups within S. bradys be separated, indicating that no subspecies were present.
An earlier published species-specific primer set was verified with the DNA of the 51
sequences and was considered a reliable and rapid method for S. bradys identification.
The Brain Health Registry: An internet‐based platform for recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies
Authors: Weiner Michael W. , Nosheny Rachel , Camacho Monica , Truran‐Sacrey Diana , Mackin R. Scott , Flenniken Derek , Ulbricht Aaron , Insel Philip , Finley Shannon , Fockler Juliet , Veitch Dallas 
Published: May 2018

AbstractIntroductionRecruitment, assessment, and longitudinal monitoring of participants for neuroscience studies and clinical trials limit the development of new treatments. Widespread Internet use allows data capture from participants in an unsupervised setting. The Brain Health Registry, a website and online registry, collects data from participants and their study partners.MethodsThe Brain Health Registry obtains self and study partner report questionnaires and neuropsychological data, including the Cogstate Brief Battery, Lumos Labs Neurocognitive Performance Test, and MemTrax Memory Test. Participants provide informed consent before participation.ResultsBaseline and longitudinal data were obtained from nearly 57,000 and 28,000 participants, respectively. Over 18,800 participants were referred to, and nearly 1800 were enrolled in, clinical Alzheimer's disease and aging studies, including five observational studies and seven intervention trials.DiscussionOnline assessments of participants and study partners provide useful information at relatively low cost for neuroscience studies and clinical trials and may ultimately be used in routine clinical practice.
Study on Rigid-Liquid Coupling Dynamics of the Spacecraft With Arbitrary Axisymmetrical Tanks
Authors: Yan Y. L. , Yue B. Z. 
Published: May 2018

AbstractThis article focus on the rigid-liquid coupling dynamics of the spacecraft with arbitrary axisymmetrical tanks with curved walls and top. The carrier velocity potential function was obtained according to the motion equations of a representative point in the tank of spacecraft, and the relative velocity potential function can be expressed as Gauss hypergeometric series. The Hamilton's variational principle was applied to derive the governing equations of liquid sloshing based on the profile of hydrostatic shape of free liquid surface. The dynamic equations of modal coordinates were established through the Galerkin method. The state equations of coupled motion of main rigid platform of the spacecraft were deduced by using the Lagrange's equations in term of general quasi-coordinates. Thruster firing was actuated to the coupled system to analyze the rigid-liquid coupled dynamic behaviors. Computer numerical simulations was carried out to confirm the validity of the method developed in this paper.
Steinernema khuongin. sp. (Panagrolaimomorpha, Steinernematidae), a new entomopathogenic nematode species from Florida, USA
Authors: Stock S.P. , Campos-Herrera R. , El-Borai F.E. , Duncan L.W. 
Published: May 2018

AbstractIn this study, molecular (ribosomal sequence data), morphological and cross-hybridization properties were used to identify a newSteinernemasp. from Florida, USA. Molecular and morphological data provided evidence for placing the novel species into Clade V, or the ‘glaseri-group’ ofSteinernemaspp. Within this clade, analysis of sequence data of the rDNA genes, 28S and internal transcribed spacer (ITS), depicted the novel species as a distinctive entity and closely related toS. glaseriandS. cubanum.Additionally, cross-hybridization assays showed that the new species is unable to interbreed with either of the latter two species, reinforcing its uniqueness from a biological species concept standpoint. Key morphological diagnostic characters forS. khuongin. sp. include the mean morphometric features of the third-stage infective juveniles: total body length (average: 1066 μm), tail length (average: 65 μm), location of the excretory pore (average: 80.5 μm) and the values ofc(average: 16.4),D% (average: 60.5),E% (average: 126) andH% (average: 46.6). Additionally, males can be differentiated fromS. glaseriandS. cubanumby the values of several ratios:D% (average: 68),E% (average: 323) and SW% (average: 120). The natural distribution of this species in Florida encompasses both natural areas and citrus groves, primarily in shallow groundwater ecoregions designated as ‘flatwoods’. The morphological, molecular, phylogenetic and ecological data associated with this nematode support its identity as a new species in theS. glaseri-group.
Omega-3 (ω-3) and social skills interventions for reactive aggression and childhood externalizing behavior problems: a randomized, stratified, double-blind, placebo-controlled, factorial trial
Authors: Raine Adrian , Ang Rebecca P. , Choy Olivia , Hibbeln Joseph R. , Ho Ringo M-H. , Lim Choon Guan , Lim-Ashworth Nikki S. J. , Ling Shichun , Liu Jean C. J. , Ooi Yoon Phaik , Tan Yi Ren , Fung Daniel S. S. 
Published: May 2018

AbstractBackgroundWhile studies suggest that nutritional supplementation may reduce aggressive behavior in children, few have examined their effects on specific forms of aggression. This study tests the primary hypothesis that omega-3 (ω-3), both alone and in conjunction with social skills training, will have particular post-treatment efficacy for reducing childhood reactive aggression relative to baseline.MethodsIn this randomized, double-blind, stratified, placebo-controlled, factorial trial, a clinical sample of 282 children with externalizing behavior aged 7–16 years was randomized intoω-3 only, social skills only,ω-3 + social skills, and placebo control groups. Treatment duration was 6 months. The primary outcome measure was reactive aggression collected at 0, 3, 6, 9, and 12 months, with antisocial behavior as a secondary outcome.ResultsChildren in theω-3-only group showed a short-term reduction (at 3 and 6 months) in self-report reactive aggression, and also a short-term reduction in overall antisocial behavior. Sensitivity analyses and a robustness check replicated significant interaction effects. Effect sizes (d) were small, ranging from 0.17 to 0.31.ConclusionsFindings provide some initial support for the efficacy ofω-3 in reducing reactive aggression over and above standard care (medication and parent training), but yield only preliminary and limited support for the efficacy ofω-3 in reducing overall externalizing behavior in children. Future studies could test further whetherω-3 shows promise in reducing more reactive, impulsive forms of aggression.
Significant spike in excess mortality in England in winter 2014/15 – influenza the likely culprit
Authors: Pebody R. G. , Green H. K. , Warburton F. , Sinnathamby M. , Ellis J. , Mølbak K. , Nielsen J. , de Lusignan S. , Andrews N. 
Published: May 2018

AbstractSignificant increases in excess all-cause mortality, particularly in the elderly, were observed during the winter of 2014/15 in England. With influenza A(H3N2) the dominant circulating influenza A subtype, this paper determines the contribution of influenza to this excess controlling for weather. A standardised multivariable Poisson regression model was employed with weekly all-cause deaths the dependent variable for the period 2008–2015. Adjusting for extreme temperature, a total of 26 542 (95% CI 25 301–27 804) deaths in 65+ and 1942 (95% CI 1834–2052) in 15–64-year-olds were associated with influenza from week 40, 2014 to week 20, 2015. This is compatible with the circulation of influenza A(H3N2). It is the largest estimated number of influenza-related deaths in England since prior to 2008/09. The findings highlight the potential health impact of influenza and the important role of the annual influenza vaccination programme that is required to protect the population including the elderly, who are vulnerable to a severe outcome.
Food environment, social deprivation and obesity among students from Brazilian public schools
Authors: Assis Maíra Macário de , Leite Maria Alvim , Carmo Ariene Silva do , Andrade Amanda Cristina de Souza , Pessoa Milene Cristine , Netto Michele Pereira , Cândido Ana Paula Carlos , Mendes Larissa Loures 
Published: May 2018

AbstractObjectiveTo investigate the relationship between social deprivation and the food environment. Furthermore, to evaluate if the food environment is associated with the prevalence of obesity among students in Brazilian public schools.DesignCross-sectional. For the classification of obesity, weight and height were measured, and the cut-off point of BMI-for-age Z-score >+2 was adopted. Social deprivation level was determined from the Health Vulnerability Index (HVI). To assess the food environment, the density of food establishments in urban residential areas was calculated. Associations between the food environment and the presence of obesity were estimated by binary logistic regression through a generalized estimating equations model.SettingJuiz de Fora, Minas Gerais, Brazil.SubjectsChildren and adolescents (n 661) aged 7–14 years.ResultsThe lowest social deprivation level showed a higher density of all types of establishments that sold predominantly unhealthy foods. An inverse association was found between the density of supermarkets and hypermarkets and the presence of obesity (OR=0·58; 95 % CI 0·36, 0·93). For the other categories of food retailers, no significant differences were found.ConclusionsThe findings reinforce the need for public policies that promote equality in the food environments of the city. Also, further investigations into the influence of the presence of supermarkets on the nutritional status of children and adolescents are required.
Rush Skeletonweed (Chondrilla juncea) Control in Pacific Northwest Winter Wheat
Authors: Spring John F. , Thorne Mark E. , Burke Ian C. , Lyon Drew J. 
Published: May 2018

AbstractRush skeletonweed is emerging as a regionally important weed of winter wheat production in eastern Washington. Field studies were conducted during the 2016 and 2017 crop years to evaluate several auxin herbicides applied at two seasonal timings (fall or spring) for control of rush skeletonweed in winter wheat. Clopyralid (210 g ae ha-1) provided>90% visual control of rush skeletonweed in both years of the study and aminopyralid (10 g ae ha-1) provided>80% visual control. Aminocyclopyrachlor, dicamba, and 2,4-D provided<55% control of rush skeletonweed. Season of application did not meaningfully affect efficacy of any herbicide tested. Wheat yields were reduced by 39 to 69% compared to the non-treated check when aminocyclopyrachlor was applied in the spring. Clopyralid is an effective option for control of rush skeletonweed in Pacific Northwest winter wheat.
Nonlinear Dynamics of Radiation Belt Electrons Interacting With Chorus Emissions Localized in Longitude
Authors: Kubota Yuko , Omura Yoshiharu 
Published: May 2018

AbstractUsing results of test particle simulations of electrons interacting with whistler mode chorus emissions, we numerically obtain Green's functions to model evolution of the electron distribution function after all of the possible interactions with the waves. In both wave models with and without subpackets, electrons undergoing the cyclotron resonance with the waves are efficiently accelerated by nonlinear wave trapping. Since the strong modulation of the wave amplitude (in the case of the waves with subpackets) affects dynamics of resonant electrons, the electrons are detrapped from the wave potential or entrapped into it more frequently than those interacting with the waves without subpackets. As a result of interaction with the waves with subpackets, the number of electrons undergoing the acceleration is increased, while the acceleration efficiency in energy is decreased because of shorter interaction time. Modifying the numerical Green's function method with the simplified model of chorus waves uniform in longitude (Omura et al., 2015, https://doi.org/10.1002/2015JA021563), we compute the formation process of the outer radiation belt electron fluxes induced by the interaction with the chorus waves localized in longitude occurring for a time scale of 1 hr. The formation of MeV electron fluxes is characterized by large acceleration rates and butterfly pitch angle distributions, which are found in satellite observation results.
Global Model of Plasmaspheric Hiss From Multiple Satellite Observations
Authors: Meredith Nigel P. , Horne Richard B. , Kersten Tobias , Li Wen , Bortnik Jacob , Sicard Angélica , Yearby Keith H. 
Published: May 2018

AbstractWe present a global model of plasmaspheric hiss, using data from eight satellites, extending the coverage and improving the statistics of existing models. We use geomagnetic activity dependent templates to separate plasmaspheric hiss from chorus. In the region 22–14 magnetic local time (MLT) the boundary between plasmaspheric hiss and chorus moves to lower values with increasing geomagnetic activity. The average wave intensity of plasmaspheric hiss is largest on the dayside and increases with increasing geomagnetic activity from midnight through dawn to dusk. Plasmaspheric hiss is most intense and spatially extended in the 200 to 500 Hz frequency band during active conditions, 400 750 nT, with an average intensity of 1,128 pT in the region 05–17 MLT from 1.5 . In the prenoon sector, waves in the 100 to 200 Hz frequency band peak near the magnetic equator and decrease in intensity with increasing magnetic latitude, inconsistent with a source from chorus outside the plasmapause, but more consistent with local amplification by substorm‐injected electrons. At higher frequencies the average wave intensities in this sector exhibit two peaks, one near the magnetic equator and one at high latitudes, 45° °, with a minimum at intermediate latitudes, 30° °, consistent with a source from chorus outside the plasmapause. In the premidnight sector, the intensity of plasmaspheric hiss in the frequency range 50 < f < 1,000 Hz decreases with increasing geomagnetic activity. The source of this weak premidnight plasmaspheric hiss is likely to be chorus at larger in the postnoon sector that enters that plasmasphere in the postnoon sector and subsequently propagates eastward in MLT.
PTBP1 enhances miR-101-guided AGO2 targeting to MCL1 and promotes miR-101-induced apoptosis
Authors: Cui Jia , Placzek William J. 
Published: May 2018

AbstractMyeloid cell leukemia 1 (MCL1) is a key anti-apoptotic protein belonging to the BCL-2 protein family. To preserve normal cellular homeostasis, cells must maintain strict control over MCL1 expression. Overexpression of MCL1 has been identified as a key contributor to tumorigenesis, and further enables resistance to a number of anti-cancer chemotherapies. Thus, there is an ongoing interest to develop selective MCL1 inhibitors. In order to better target MCL1, it is essential to understand the molecular mechanisms that regulate MCL1 expression in cells. While MCL1 expression is tightly controlled by multiple mechanisms, the post-transcriptional regulation of MCL1 mRNA is poorly studied. Our previous work identified that polypyrimidine tract binding protein 1 (PTBP1) binds to MCL1 mRNA and represses MCL1 expression by destabilizing MCL1 mRNA. In this report, we show that PTBP1 modulates MCL1 expression by regulating the microRNA (miRNA) direction of the miRNA-induced silencing complex (miRISC) to MCL1. We demonstrate that PTBP1 enhances miR-101-guided AGO2 interaction with MCL1, thereby regulating miR-101-induced apoptosis and clonogenic cell survival inhibition in cells. Taken together, not only do these studies expand our understanding on the regulation of MCL1, they also demonstrate that PTBP1 and miRNAs can function cooperatively on a shared target mRNA.
Prion protein is essential for the RE1 silencing transcription factor (REST)-dependent developmental switch in synaptic NMDA receptors
Authors: Song Zhiqi , Yang Wei , Cheng Guangyu , Zhou Xiangmei , Yang Lifeng , Zhao Deming 
Published: May 2018

AbstractIt is important that the correct amounts of GluN2 subunits are maintained, as they determine NMDAR functional properties, which are crucial to neuronal communication, synaptogenesis and cognitive function. The transcriptional repressor RE1 silencing transcription factor (REST) is critical for the postnatal developmental switch in NMDARs. However, the mechanisms triggering REST and the link between NMDARs and REST are unclear. Here we show a new physiological essential role for cellular prion protein (PrPC) in REST-dependent homeostasis and the developmental switch of NMDARs. REST and REST-associated proteins were overactivated in the hippocampi of Prnp knockout mice (Prnp
0/0
) compared with wild-type Prnp (Prnp
+/+
) mice. This coincided with the disruption of the normal developmental switch from GluN2B-to-GluN2A in vivo. PrPC co-located with REST under physiological environments and mediated the translocation of REST in conditioners of NMDARs in vitro in Prnp
+/+
hippocampal neurons. Regardless of whether REST was knocked down or overexpressed, deletion of PrPC not only disrupted REST-mediated distribution of mitochondria, but also prevented REST-regulated expression of GluN2B and GluN2A in Prnp
0/0
. Importantly, these effects were rescued after overexpression of full-length PrPC through restoration of NMDAR2 subunits and their distributions in dendritic processes in Prnp
0/0
. Consistently, knockdown of PrPC in Prnp
+/+
had a similar effect on Prnp
0/0
. Furthermore, PrPC colocalized with both GluN2B and GluN2A in Prnp
+/+
. For the first time, we demonstrate that PrPC is essential for REST-regulated NMDARs. Confirming the regulation of NMDAR-modulating mechanisms could provide novel therapeutic targets against dysfunctions of glutamatergic transmission in the nervous system.
TSPY1 suppresses USP7-mediated p53 function and promotes spermatogonial proliferation
Authors: Shen Ying , Tu Wenling , Liu Yunqiang , Yang Xiling , Dong Qiang , Yang Bo , Xu Jinyan , Yan Yuanlong , Pei Xue , Liu Mohan , Xu Wenming , Yang Yuan 
Published: May 2018

AbstractTestis-specific protein Y-linked 1 (TSPY1) is expressed predominantly in adult human spermatogonia and functions in the process of spermatogenesis; however, our understanding of the underlying mechanism is limited. Here we observed that TSPY1, as an interacting partner of TSPY-like 5 (TSPYL5), enhanced the competitive binding of TSPYL5 to ubiquitin-specific peptidase 7 (USP7) in conjunction with p53. This activity, together with its promotion of TSPYL5 expression by acting as a transcription factor, resulted in increased p53 ubiquitylation. Moreover, TSPY1 could decrease the p53 level by inducing the degradation of ubiquitinated USP7. We demonstrated that the promotion of p53 degradation by TSPY1 influenced the activity of p53 target molecules (CDK1, p21, and BAX) to expedite the G2/M phase transition and decrease cell apoptosis, accelerating cell proliferation. Taken together, the observations reveal the significance of TSPY1 as a suppressor of USP7-mediated p53 function in inhibiting p53-dependent cell proliferation arrest. By simulating TSPY1 function in Tspy1-deficient spermatogonia derived from mouse testes, we found that TSPY1 could promote spermatogonial proliferation by decreasing the Usp7-modulated p53 level. The findings suggest an additional mechanism underlying the regulation of spermatogonial p53 function, indicating the significance of TSPY1 in germline homeostasis maintenance and the potential of TSPY1 in regulating human spermatogonial proliferation via the USP7-mediated p53 signaling pathway.