bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing Attachment and Biobehavioral Catch‐Up with birth parents: Rationale and case example
Authors: Hoye Julie R. , Dozier Mary 
Published: May 2018

AbstractAttachment and Biobehavioral Catch‐Up (ABC) is an intervention designed for vulnerable children and their parents. This intervention enhances parental sensitivity and nurturance with the goal of promoting secure, organized attachments and strong self‐regulatory capabilities among children. Here, we provide a brief rationale for the need for such interventions to be delivered to parent‐child dyads in the child welfare system. Next, we review specific intervention targets of ABC. We include a case example of two birth parents and their daughter who became involved in Child Protective Services due to domestic violence.
An Evaluation of Efficacy and Safety of Commonly Prescribed Drugs and Effect of These Drugs on Quality of Sleep in Patients Suffering From Zoster‐Associated Pain
Authors: Nayak Mithilesh K. , Kapadia Jigar D. , Desai Chetna K. , Desai Mira K. , Shah Bela J. 
Published: May 2018

AbstractThis observational, prospective, single‐center study was conducted to evaluate the efficacy and safety of commonly prescribed drugs for zoster‐associated pain and their impact on quality of sleep at a tertiary care hospital in western India. Patients ≥18 years of age, newly diagnosed with zoster‐associated pain were evaluated on days 0, 7, 14, 30, 60, 90, 120, 150, and 180 or until resolution of pain, whichever was earlier, using the Wong Baker FACES Pain Rating Scale, Neuropathic Pain Scale, and Insomnia Severity Index for intensity of pain, quality of pain, and quality of sleep, respectively. A total of 78 patients (46.0 [16.3] years) completed the study. They received nonsteroidal anti‐inflammatory drugs (65), gabapentin (30), amitriptyline (27), and amitriptyline + gabapentin (21) for mean durations of 7.7 (3.0), 89.2 (7.2), 107.6 (46.3), and 104.5 (46) days, respectively. Improvement in the Wong Baker FACES Pain Rating Scale and Neuropathic Pain Scale score was similar among treatment groups except for a greater fall in Wong Baker FACES Pain Rating Scale score at days 7 and 120 and that in deep pain score at day 7 in combination treatment group vs the amitriptyline group. Clinically significant insomnia was detected in 35 patients at baseline and demonstrated progressive and similar improvement among groups. Treatment modification was required in 20 patients. Zoster‐associated pain resolved in 69 patients. Nine adverse drug reactions, mostly mild, nonserious, and nonpreventable, were reported. To conclude, drugs commonly used for zoster‐associated pain are effective and well tolerated. These have a similar effect on pain and quality of sleep, except for a possible greater effect of combination treatment in the early phase of intense and deep pain.
Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride
Authors: Bona Silvia , Rodrigues Graziella , Moreira Andrea J , Di Naso Fábio C , Dias Alexandre S , Da Silveira Thêmis R , Marroni Claudio A , Marroni Norma P 
Published: May 2018

Background and AimLiver diseases are a major public health problem, accounting for a significant number of hospital visits and admissions and an increasing mortality rate. Melatonin (MLT) is a powerful antioxidant molecule that has been shown to be beneficial under various conditions. The objective was to evaluate the effect of MLT on experimental liver cirrhosis induced by carbon tetrachloride (CCl4) in rats.MethodsTwenty male Wistar rats (230–250 g) were divided into four groups. I: control group (CO); II: CO + MLT; III: CCl4; and IV: CCl4 + MLT. CCl4 was administered intraperitoneally (i.p.) as follows: 10 doses every 5 days, 10 doses every 4 days, and 7 doses every 3 days. MLT was administered i.p. at a dose of 20 mg/kg from the 10th week to the end of the experiment (16th week).ResultsIn the CCl4 + MLT group, we found that MLT caused a decrease in the level of F2‐isoprostanes and NQO1 expression. We also found that MLT reduced the inflammatory process as shown by decreased expressions of NF‐KB/p65 and inducible nitric oxide synthase (iNOS) and a smaller amount of inflammatory infiltrate. MLT reduced the expression of transforming growth factor beta1 (TGF‐β1), alpha‐smooth muscle actin (α‐SMA), and vascular endothelial growth factor (VEGF). Picrosirius staining showed that MLT decreases fibrosis.ConclusionMLT has a potent antifibrogenic effect, modulating the parameters of oxidative stress, angiogenesis, and inflammation.
Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity
Authors: Cai Yunpeng , Makarova Anna‐Marie , Wengel Jesper , Howard Kenneth A. 
Published: May 2018

AbstractBackgroundAntisense gapmer oligonucleotide drugs require delivery and biodistribution enabling technologies to increase in vivo efficacy. An attractive approach is their binding and consequent transport by the endogenous human serum albumin pool as mediated by fatty acid incorporation into the gapmer design.MethodsThe present study investigated the effect of palmitoyl modification and position on albumin‐binding, cellular uptake and in vitro gene silencing of gapmers with either a phosphorothioate (PS) or phosphodiester (PO) backbone.ResultsTwo palmitoyls positioned exclusively at the 5′ end, or a single palmitoyl at both the 3′ and 5′ positions, showed similar binding to human serum albumin as demonstrated by a gel‐shift assay. Decreased cellular uptake determined by flow cytometry (27% compared to nonpalmitoyl gapmers) was observed for palmitoylated Cy5.5 labelled gapmers. However, HER3 (human epidermal growth factor receptor 3) gene silencing was exhibited by the palmitoylated gapmers with transfection agent in PC‐3 and Caco‐2 cells (68% and 62%, respectively), which was comparable to nonpalmitoyl gapmers (68% and 82%, respectively). Importantly, PO gapmers with a single palmitoyl positioned at both the 3′ and 5′ positions showed high silencing efficiencies (68% and 66% in PC‐3 and Caco‐2 cells, respectively) similar to those of PS nonpalmitoylated gapmers (67% and 66% in PC‐3 and Caco‐2 cells, respectively) in the absence of a transfection agent.ConclusionsThe present study defines phosphodiester gapmer design criteria exhibiting high gene silencing activity and albumin binding that may be utilized with potentially less in vivo toxicity that can be associated with phosphorothioate gapmer designs.
Histological effects and pharmacokinetics of lipopolysaccharide derived from Porphyromonas gingivalis on rat maxilla and liver concerning with progression into non‐alcoholic steatohepatitis
Authors: Fujita Miyako , Kuraji Ryutaro , Ito Hiroshi , Hashimoto Shuichi , Toen Toshiyuki , Fukada Tetsuya , Numabe Yukihiro 
Published: May 2018

AbstractBackgroundNon‐alcoholic steatohepatitis (NASH) is one of the chronic liver diseases that can develop into hepatocirrhosis. The purpose of the present study was to investigate the impact of lipopolysaccharide (LPS) from Porphyromonas gingivalis (P. gingivalis) on NASH onset, and to determine the biodistribution of double‐radiolabeled LPS (R‐LPS) biosynthesized in P. gingivalis.MethodsRats fed a basal diet (BD) or a high‐fat diet (HD) were injected with P. gingivalis‐LPS or R‐LPS into the palatine gingiva around the right maxillary first molar, and were classified into the following 4 groups: BD/LPS (‐), BD/LPS (+), HD/LPS (‐), and HD/LPS (+) or 2 groups: BD/R‐LPS and HD/R‐LPS.ResultsInflammation in the gingiva of the LPS (+) groups progressed significantly more than the LPS (‐) groups. Furthermore, in the HD/LPS (+) liver, histologic analysis confirmed the presence of NASH, characterized by large fat droplets, ballooning degeneration, and infiltration of inflammatory cells. When 3H, 14C‐R‐LPS was injected into the palatine gingiva, radioactivity in the right palatal mucosa of HD/R‐LPS rats was the highest in comparison with other regions and was significantly elevated after 24 hours compared to BD/R‐LPS rats. Autoradiographic analysis of the maxilla showed distributions from the palatal mucosa to the hard palate and the interdental region. Radioactivity in organs of both BD/R‐LPS and HD/R‐LPS rats were mostly localized to the liver even after 24 hours.ConclusionThe present study suggests that the transfer of P. gingivalis‐LPS from the oral cavity to the liver plays an important role in disease exacerbation of NASH.
Immunological and microbiological periodontal profiles in isolated growth hormone deficiency
Authors: Araújo I.M.P. , Albuquerque‐Souza E. , Aguiar‐Oliveira M.H. , Holzhausen M. , Oliveira‐Neto L.A. , Salvatori R. , Saraiva L. , Mayer M.P.A. , Pannuti C.M. , Ribeiro A.O. , Romito G.A. , Pustiglioni F.E. 
Published: May 2018

AbstractBackgroundGrowth hormone (GH) has been identified as an important regulator of the immune response. We have previously shown that adults with isolated GH deficiency (IGHD) due to a mutation in the GH releasing hormone receptor (GHRHR) gene, have a greater chance of having periodontitis. However, the interaction of GH with periodontal tissues is still unknown, and this population has emerged as a unique model to investigate this issue. Therefore, we evaluated the microbiological and immunological periodontal profiles of such individuals.MethodsNineteen IGHD and 19 controls matched by age, sex, diabetes, and smoking status, were enrolled in this case‐control study. Periodontal clinical parameters (probing depth [PD] and clinical attachment loss [AL]) were measured at six sites per tooth. Immune mediators (C‐reactive protein, matrix metalloproteinase [MMP]‐8, MMP‐9, interleukin [IL]‐1α, IL‐6, IL‐8, tumor necrosis factor [TNF]‐α, adiponectin, and leptin) were analyzed by enzyme‐linked immunosorbent assay (ELISA) in the gingival crevicular fluid (GCF) in four non‐adjacent sites for each participant (two with PD ≤3 mm [shallow sites] and two with PD ≥7 mm or the worst PD found in the mouth [deep sites]). Bacterial quantification (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia) of subgingival biofilm samples collected from these same sites was performed by quantitative real‐time polymerase chain reaction (qPCR).ResultsIGHD individuals presented higher values of PD and AL, and increased levels of CRP, IL‐8, MMP‐8, and adiponectin in the GCF. Bacterial quantification did not identify differences between the two groups.ConclusionIGHD alters the local immune response in periodontal pockets leading to greater attachment loss, and GH stands out as an important hormone to be evaluated in the pathogenesis of periodontitis.
Determination of Sodium Dodecyl Sulfate by Means of Photometric Titration with o‐Toluidine Blue Dye
Authors: Ziółkowska Dorota , Lamkiewicz Jan , Shyichuk Alexander 
Published: May 2018

AbstractA convenient technique for the determination of sodium dodecyl sulfate is titration with a metachromatic dye using in situ absorbance measurements. A suitable color reagent is ortho‐Toluidine Blue dye. Commercially available immersion optical probe Optrode® possesses a working wavelength of 640 nm, well matching the dye spectrum. The surfactant concentration is linearly related to the titrant volume at a certain solution absorbance. Optimal values of end point absorbance fall in the range from 0.7 to 2. The lower limit of quantitation is equal to 29 mg L−1. The highest concentration determined in this study was 52 g L−1. The required determination range may be adjusted by the appropriate selection of analyte volume and titrant concentration. The developed method is intended for routine process control in the surfactant industry. This method needs minimal manual efforts due to the lack of the dilution stage. Application of an automatic titrator looks to be a suitable solution for any industrial lab.
Preoperative radiation therapy in the surgical management of gastric and junctional adenocarcinoma: Should lymph node retrieval guidelines be altered?
Authors: Lane Whitney O. , Nussbaum Daniel P. , Sun Zhifei , Blazer Dan G. 
Published: May 2018

BackgroundAlthough surgery remains the cornerstone of gastric cancer therapy, the use of radiation therapy (RT) is increasingly being employed to optimize outcomes. We sought to assess outcomes following use of RT for the treatment of gastric adenocarcinoma.MethodsUsing the National Cancer Data Base (NCDB) from 1998 to 2012, all patients with resected gastric adenocarcinoma were identified. Patients were stratified into four groups based on preoperative therapy: RT alone, chemotherapy only, chemoradiotherapy (CRT), and no preoperative therapy. Overall survival was estimated using multivariate Cox proportional hazards model. Adjusted secondary outcomes include margin positivity, lymph node harvest, LOS, 30‐day readmission and mortality.ResultsA total of 10 019 patients met study criteria. In the unadjusted analysis, patients undergoing CRT compared to chemotherapy alone had fewer positive margins (7.9% vs 15.9%; P < 0.001), increased negative LNs (54.6% vs 37.7%; P < 0.001) with reduced LN retrieval (mean: 13.5 vs 19.6; P < 0.01). After multivariate adjustment, there was no survival benefit to any preoperative therapy; however, preoperative RT/CRT remained associated with decreased LN retrieval.ConclusionsThe results support previous reports on preoperative RT resulting in decreased margin positivity. This study highlights the need to reconsider practice guidelines regarding appropriate lymphadenectomy in the setting of preoperative RT given reduced LN retrieval.
Identification of volatile markers for the detection of adulterants in red ginseng (Panax ginseng) juice using headspace stir‐bar sorptive extraction coupled with gas chromatography and mass spectrometry
Authors: Lee Jangho , Shibamoto Takayuki , Ha Jaeho , Jang Hae Won 
Published: May 2018

AbstractRed ginseng (Panax ginseng) products are frequently adulterated by manufacturers with cheaper medicinal plant products including deodeok (Codonopsis lanceolata) and doraji (Platycodon grandiflorum) to increase profits. To identify possible volatile markers for the adulteration of red ginseng juices with deodeok or doraji, a headspace stir‐bar sorptive extraction method was developed. Gas chromatography with mass spectrometry and untargeted metabolomics analysis revealed that 1‐hexanol, cis‐3‐hexen‐1‐ol, and trans‐2‐hexen‐1‐ol are abundantly present in deodeok and doraji but not red ginseng. The peak area ratios in gas chromatograms of these compounds in red ginseng juices mixed with deodeok or doraji indicate that these volatile chemicals can be used as markers to detect the adulteration of red ginseng juice.
Evaluating the waterfowl breeding population and habitat survey for scaup
Authors: Schummer Michael L. , Afton Alan D. , Badzinski Shannon S. , Petrie Scott A. , Olsen Glenn H. , Mitchell Mark A. 
Published: May 2018

ABSTRACTPotential bias in breeding population estimates of certain duck species from the Waterfowl Breeding Population and Habitat Survey (WBPHS) has been a concern for decades. The WBPHS does not differentiate between lesser (Aythya affinis) and greater (A. marila) scaup, but lesser scaup comprise 89% of the combined scaup population and their population estimates are suspected to be biased. We marked female lesser scaup (i.e., marked scaup) in the Mississippi and Atlantic Flyways, Canada and United States, with implantable satellite transmitters to track their spring migration through the traditional and eastern survey areas of the WBPHS, 2005–2010. Our goal was to use data independent of the WBPHS to evaluate whether breeding population estimates for scaup were biased and identify variables that might be used in the future to refine population estimates. We found that the WBPHS estimates of breeding scaup are biased because, across years, only 30% of our marked scaup had settled for the breeding period when the strata in which they settled were surveyed, 43% were available to be counted in multiple survey strata as their migration continued during the WBPHS, 32% settled outside the WBPHS area, the number of times a marked scaup was available to be counted by survey crews varied positively with the latitude that a marked scaup settled on breeding areas, the probability of a marked scaup being in a stratum while it was surveyed varied among years, and these probabilities were positively correlated with the traditional and eastern breeding population estimates for scaup. Annual population estimates derived from banding data provide a less biased and preferable method of monitoring scaup population status and trend. Development of models that include metrics such as survey stratum latitude and annual spring environmental conditions might potentially be used to improve scaup breeding population estimates derived from the WBPHS, but independent estimates from banding data would be important to evaluate such models. © 2018 The Wildlife Society.
Middle ear irrigation using a hydrodebrider decreases biofilm surface area in an animal model of otitis media
Authors: Abi Hachem Ralph , Goncalves Stefania , Walker Thomas , Angeli Simon 
Published: May 2018

ObjectiveTo compare the safety and efficacy of manual and powered irrigation of the middle ear using saline or 1% baby shampoo to treat biofilm‐forming bacterial middle ear infections.BackgroundBiofilms play a major role in recalcitrant otitis media and are challenging to treat. Many therapeutic strategies have been attempted and the role of topical therapies is still being investigated. Topical irrigation using saline or 1% baby shampoo and the use of a hydrodebrider have been investigated in biofilms involved in chronic rhinosinusitis and their role within the middle ear is yet to be determined.MethodsTwenty‐two adult chinchillas underwent bilateral trans‐bullar inoculation of non‐typable biofilm forming Haemophilus influenza followed by unilateral middle ear irrigation 5 days later using saline administered via a powered hydrodebrider or manual irrigation of saline or 1% baby shampoo. Contralateral inoculated ears served as control and were not irrigated. Two days following irrigation, the bullae were harvested and processed for scanning electron microscopy to assess biofilm surface area. Auditory brainstem responses were performed before bacterial inoculation and prior to euthanasia.ResultsManual and powered irrigation were effective in reducing the surface area of biofilm when compared to the control group. The hydrodebrider demonstrated to be more effective at eradicating biofilm than manual irrigation, especially in areas of difficult access, such as the ventral portion of the chinchillas' bullae. There was no difference in manual irrigation of saline when compared to 1% baby shampoo. Irrigations either manually or using the hydrodebrider did not affect hearing, the vestibular system or facial function.ConclusionMiddle ear biofilms can be treated safely and effectively with rinses using either normal saline or 1% baby shampoo administered manually or with a powered hydrodebrider.Level of EvidenceNA.
Anapole Mode Sustaining Silicon Metamaterials in Visible Spectral Range
Authors: Ospanova Anar K. , Stenishchev Ivan V. , Basharin Alexey A. 
Published: May 2018

AbstractThis paper is dedicated to a type of perforated silicon metamaterials, possessing anapole mode in visible spectral range due to destructive interference between electric and toroidal dipole moments. The proposed structure gains both in attainable material and simplified fabrication. Such a material exhibits a desirable physical effect and has obvious practical application: it supports the anapole mode without complicated 3D toroidal geometry and can be processed in one step by nanofabrication methods. The metamaterial paves the way for advanced optical devices on the base of all‐dielectric metamaterials. Besides inherently low dissipative losses and strong anapole response, such an optical metamaterial can demonstrate subtle sensing, nonradiative data transfer, Aharonov‐Bohm effect and other tempting applications in nanophotonics.
OCT‐based angiography of human dermal microvascular reactions to local stimuli: Implications for increasing capillary blood collection volumes
Authors: Men Shaojie , Wong Jennifer Manyu , Welch Emily J. , Xu Jingjiang , Song Shaozhen , Deegan Anthony J. , Ravichander Aarthi , Casavant Benjamin , Berthier Erwin , Wang Ruikang K. 
Published: May 2018

ObjectivesTo measure and compare microvascular responses within the skin of the upper arm to local stimuli, such as heating or rubbing, through the use of optical coherence tomography angiography (OCTA), and to investigate its impact on blood volume collection.Materials and MethodsWith the use of heat packs or rubbing, local stimulation was applied to the skin of either the left or right upper arm. Data from the stimulated sites were obtained using OCTA comparing pre‐ and post‐stimulation microvascular parameters, such as vessel density, mean vessel diameter, and mean avascular pore size. Additionally, blood was collected using a newly designed collection device and volume was recorded to evaluate the effect of the skin stimulation.ResultsNineteen subjects were recruited for local stimulation study (including rubbing and heating) and 21 subjects for blood drawn study. Of these subjects, 14 agreed to participate in both studies. OCTA was successful in monitoring and measuring minute changes in the microvasculature of the stimulated skin. Compared to baseline, significant changes after local heating and rubbing were respectively found in vessel density (16% [P = 0.0004] and 33% [P < 0.0001] increase), mean vessel diameter (14% and 11% increase) and mean avascular pore size (5% [P = 0.0068] and 8% [P = 0.0005] decrease) after stimulations. A gradual recovery was recorded for each parameter, with no difference being measured after 30 minutes. Blood collection volumes significantly increased after stimulations of heating (48% increase; P = 0.049) and rubbing (78% increase; P = 0.048). Significant correlations were found between blood volume and microvascular parameters except mean avascular pore size under the heating condition.ConclusionsOCTA can provide important information regarding microvascular adaptations to local stimuli. With that, both heating and rubbing of the skin have positive effects on blood collection capacity, with rubbing having the most significant effect. Lasers Surg. Med. 50:908–916, 2018. © 2018 Wiley Periodicals, Inc.
Local uniform stability for the semilinear wave equation in inhomogeneous media with locally distributed Kelvin–Voigt damping
Authors: Astudillo M. , Cavalcanti M. M. , Fukuoka R. , Gonzalez Martinez V. H. 
Published: May 2018

AbstractWe consider the semilinear wave equation posed in an inhomogeneous medium Ω with smooth boundary subject to a local viscoelastic damping distributed around a neighborhood ω of the boundary according to the Geometric Control Condition. We show that the energy of the wave equation goes uniformly and exponentially to zero for all initial data of finite energy taken in bounded sets of finite energy phase‐space. As far as we know, this is the first stabilization result for a semilinear wave equation with localized Kelvin–Voigt damping.