bluuebunny/crossref_metadata_2025_split huggingface dataset:
A research note on the article of “Quality framework in education through application of interpretive structural modeling”
Authors: Roshani Kosar , Owlia Mohammad S. , Abooie Mohammad H. 
Published: July 2018

Purpose
This paper is a research note on “Quality framework in education through application of Interpretive Structural Modeling” (Sahney, S., Banwet, D.K. and Karunes, S. (2010), Quality framework in education through the application of Interpretive Structural Modeling: an administrative staff perspective in the Indian context, The TQM Journal, 22(1)). Sahney et al. applied Interpretive Structural Modeling (ISM) to prioritize, sequence and categorize elements critical to quality management in education; however, it seems that the final reachability matrix, and consequently the results, may not be true as some transitivity was not incorporated. So, the purpose of this paper is to apply a method to develop a transitive and compatible reachability matrix.

Design/methodology/approach
A counter-example was used to show that the final reachability matrix was incorrect, and then, based on Warfield’s studies, a transitive and compatible reachability matrix was developed directly.

Findings
As high priority should be placed on tackling the design characteristics which have a high driving power and thus possessing the capability to inﬂuence other elements, the correct analysis of ISM and its consequences is important to the priorities. The results from this study differed from the results of the Sahney et al. to a large extent. According to their analysis, all attributes were in the linkage area which has high driving power and high dependence. However, the authors reached different values for the relative importance and the interdependencies among the elements resulting in three different clusters.

Originality/value
This note clarifies and corrects the way the ISM methodology can be applied.
Correlation‐based reflection waveform inversion by one‐way wave equations
Authors: Dong Liangguo , Fan Zhongyi , Wang Hongzhi , Chi Benxin , Liu Yuzhu 
Published: July 2018

ABSTRACTReflection full waveform inversion can update subsurface velocity structure of the deeper part, but tends to get stuck in the local minima associated with the waveform misfit function. These local minima cause cycle skipping if the initial background velocity model is far from the true model. Since conventional reflection full waveform inversion using two‐way wave equation in time domain is computationally expensive and consumes a large amount of memory, we implement a correlation‐based reflection waveform inversion using one‐way wave equations to retrieve the background velocity. In this method, one‐way wave equations are used for the seismic wave forward modelling, migration/de‐migration and the gradient computation of objective function in frequency domain. Compared with the method using two‐way wave equation, the proposed method benefits from the lower computational cost of one‐way wave equations without significant accuracy reduction in the cases without steep dips. It also largely reduces the memory requirement by an order of magnitude than implementation using two‐way wave equation both for two‐ and three‐dimensional situations. Through numerical analysis, we also find that one‐way wave equations can better construct the low wavenumber reflection wavepath without producing high‐amplitude short‐wavelength components near the image points in the reflection full waveform inversion gradient. Synthetic test and real data application show that the proposed method efficiently updates the background velocity model.
Phosphate Binders Derived from Natural Ores Contain Many Kinds of Metallic Elements Besides Their Active Ingredient Metals
Authors: Nagano Nobuo , Minegishi Ayako , Ito Kyoko , Ando Tetsuo , Tsutsui Takaaki , Ogawa Tetsuya 
Published: July 2018

ABSTRACTMost patients undergoing dialysis are required to take many phosphate binder pills to control hyperphosphatemia. Phosphate binders prescribed in Japan are classified into two types: metal‐based binders (Ca carbonate, lanthanum carbonate, ferric citrate hydrate, and sucroferric oxyhydroxide) and chemically synthesized polymers (sevelamer hydrochloride and bixalomer). The raw materials of metal‐based phosphate binders are natural ores; thus, such binders may contain several other metallic elements. We measured the elemental contents in six metal‐based phosphate binders using an inductively coupled plasma mass – spectrometry (ICP‐MS) method. As a result, despite being in small amounts, ore‐derived phosphate binders contained various elements besides their active ingredient metals: Na, Mg, P, Mn, Fe, Sr, Y, Ba, La, Nd, and Pb in three Ca‐based products; Mg, P, Se, Ce, and Gd in one La‐based product; and Na, Mg, Al, P, Ca, Ti, Cr, Mn, Co, Ni, Ge, Ba, and La in two Fe‐based products. These elements are considered to have originated from pharmaceutical bulk and from pharmaceutical additives. It is unlikely these elements are immediately harmful to patients. However, it should be emphasized that patients undergoing dialysis do not have a urinary excretion route and are administered many phosphate binder pills every day over a long period of time. In the future, pharmaceutical companies may have to disclose standard amounts and/or analytical values regarding the type and quantity of metallic elements in the final formulation or pharmaceutical bulk derived from natural ores.
Risk of depression in patients with inflammatory bowel disease
Authors: Geiss Thomas , Schaefert Rainer M , Berens Sabrina , Hoffmann Peter , Gauss Annika 
Published: July 2018

OBJECTIVEDepression is more prevalent in patients with inflammatory bowel disease (IBD) than in the general population. This study evaluated disease‐related risk factors for depression in Crohn's disease (CD) and ulcerative colitis (UC).METHODSAltogether 348 patients with IBD (228 with CD, 120 with UC) were included at our Outpatient IBD Clinic. Their characteristics, laboratory results and scores of depression, quality of life and clinical disease activity were retrospectively retrieved from questionnaires and medical records. The patient health questionnaire 9 (PHQ‐9) was used as an algorithm for a probable diagnosis of major depression employing a cut‐off point ≥10. Logistic regression analyses were performed to identify risk factors for depression.RESULTSAmong these patients, 163 (46.8%) had no or minimal depression (PHQ‐9 score 0–4), 108 (31.0%) had mild depression (PHQ‐9 score 5–9) and 77 (22.1%) were at risk of major depression (PHQ‐9 score ≥10). Patients with CD had a higher risk of major depression than those with UC (25.4% vs 15.8%, P = 0.040). PHQ‐9 scores correlated strongly with clinical disease activity and quality of life scores in both groups but only weakly and solely in the CD group with biochemical disease activity. Clinical disease activity was identified as the only independent risk factor for depression in CD (odds ratio 7.814, 95% CI 2.688–22.717, P < 0.001), while no independent risk factor for depression was detected in UC.CONCLUSIONAchieving clinical remission in patients with IBD seems to be the most important factor to reduce the risk of depression.
Post‐marketing studies of pharmaceutical opioid abuse‐deterrent formulations: a framework for research design and reporting
Authors: Peacock Amy , Larance Briony , Bruno Raimondo , Pearson Sallie‐Anne , Buckley Nicholas A. , Farrell Michael , Degenhardt Louisa 
Published: July 2018

AbstractBackground and aimsOpioid formulations with properties to deter abuse (abuse‐deterrent formulations; ADFs) have been developed as one response to the prescription opioid ‘epidemic’. As for all medicines, ADFs undergo evaluation of safety and efficacy prior to registration for marketing. However, reduced extra‐medical use (the primary intended outcome of ADFs and reason for their introduction) can only be established in post‐marketing observational studies, comparing them to opioid formulations without abuse‐deterrent properties. This has implications for various features of study design and analysis. We discuss proposals for the design, conduct, governance and reporting of post‐marketing studies on the effectiveness of pharmaceutical and opioid ADFs.MethodsA review of current guidance documents, public work‐shops and forums and our own experience with post‐marketing studies of ADFs.Results and conclusionsResearch questions for post‐marketing studies on ADFs of opioids should reasonably be framed around detecting any probable intended or unintended clinical and/or meaningful changes in specific aspects of extra‐medical use (e.g. injection use) and harms. Outcomes reported by prevalence and frequency of occurrence and disaggregated by specific product and route of administration can illustrate the magnitude of ADF impact. We argue that a multi‐faceted approach is required, using data from both general population and sentinel high‐risk cohorts and from primary and secondary data sources. The comparator (historical non‐ADF formulation of that opioid, equivalent current generic or similar opioid product), duration of monitoring and analytical approach require justification and should be sufficient to add weight to conclusions of causality. To maximize transparency, we recommend explicit declarations of funding and conflict of interest, establishment of an advisory committee, publication of study protocol and access to study results.
Cyclophosphamide‐induced hemorrhagic cystitis in young patients with solid tumors: A single institution study
Authors: Saito Yoshimasa , Kumamoto Tadashi , Shiraiwa Miki , Sonoda Tomoko , Arakawa Ayumu , Hashimoto Hironobu , Tamai Ikumi , Ogawa Chitose , Terakado Hiroyuki 
Published: July 2018

AbstractAimAlthough hemorrhagic cystitis (HC) is a significant complication in young patients who undergo chemotherapy with cyclophosphamide (CPA), risk factors and supportive care to prevent HC are unclear. This study attempted to identify optimal supportive care to prevent CPA‐induced HC.MethodsPatients (< 30‐year‐old) with malignant solid tumors who had been treated with CPA‐containing chemotherapy in inpatient treatment were eligible. Vigorous hydration to increase urine output and intravenous 2‐mercaptethane sulfonate (mesna) were used for prophylaxis of CPA‐induced HC. We retrospectively analyzed 81 patients who had been treated with CPA‐containing chemotherapy over (collectively) 486 cycles, and examined relationships between HC and various factors, especially CPA dosage, use of mesna, and fluid infusion volume/rate.ResultsHC occurred in four patients (4.9%) and five cycles (1%). When stratifying by doses and methods of administration of CPA, HC occurred in 3/323 low‐ and intermediate‐dose (< 1500 mg/m2/day) cycles and mesna was used in all three cycles with HC. Patients who were given mesna had a lower flow rate than those given hydration alone in the low‐ and intermediate‐dose CPA (126 ± 25 vs 106 ± 16 mL/m2/h; P < 0.01). All patients who received high‐dose CPA (≥1500 mg/m2/day) were also given mesna and vigorous hydration (115 ± 16 mL/m2/h).ConclusionsOur supportive care measures may be effective in preventing CPA‐induced HC. Patients who receive CPA doses < 1500 mg/m2/day should get ≥125 mL/m2/h of infused fluid, regardless of mesna usage; those who receive of CPA ≥1500 mg/m2/day should also receive mesna and vigorous hydration.
Healthcare resource utilization and costs associated with incremental systemic corticosteroid exposure in asthma
Authors: Voorham Jaco , Xu Xiao , Price David B. , Golam Sarowar , Davis Jill , Zhi Jie Ling Joanna , Kerkhof Marjan , Ow Mandy , Tran Trung N. 
Published: July 2018

AbstractBackgroundAlthough systemic corticosteroid (SCS) treatment, irrespective of duration or dosage, is associated with adverse outcomes for patients with asthma, the longitudinal effects of this treatment on adverse outcomes, healthcare resource utilization (HCRU), and healthcare costs are unknown.MethodsWe identified patients initiating intermittent or long‐term SCS who were diagnosed with active asthma from UK general practice with linked secondary care data. Control (non‐SCS) patients were matched by sex and index date with those initiating SCS. Minimum baseline period was 1 year prior to index date; minimum follow‐up duration was 2 years post–index date. Cumulative incidence of SCS‐associated adverse outcomes and associated HCRU and costs were compared between SCS and non‐SCS patient groups and among average SCS daily exposure categories. Associations between exposure and annualized HCRU and costs were assessed, adjusted for confounders.ResultsAnalyses included 9413 matched pairs. Median (interquartile range) follow up was as follows: SCS group: 7.1 (4.1‐11.8) years; control group: 6.4 (3.8‐10.0) years. Greater SCS dosages were correlated with greater cumulative incidence. For example, patients with type 2 diabetes receiving an average daily dosage of ≥7.5 mg had a 15‐year cumulative incidence (37.5%) that was 1.5‐5 times greater than those receiving lower dosages. HCRU and costs increased annually for SCS patients but not for non‐SCS patients. Increases in all‐cause adverse outcome (excluding asthma)–associated HCRU and costs were dose‐dependent.ConclusionsOver the long term, adverse outcomes associated with SCS initiation were relatively frequent and costly, with a positive dosage–response relationship with SCS exposure.
Type 2/Th2‐driven inflammation impairs olfactory sensory neurogenesis in mouse chronic rhinosinusitis model
Authors: Rouyar Angela , Classe Marion , Gorski Raphael , Bock Marie‐Dominique , Le‐Guern Joelle , Roche Sandrine , Fourgous Valerie , Remaury Anne , Paul Pascal , Ponsolles Clara , Françon Dominique , Rocheteau‐Beaujouan Laurence , Clément Margerie , Haddad El‐Bdaoui , Guillemot Jean‐Claude , Didier Michel , Biton Bruno , Orsini Cecile , Mikol Vincent , Leonetti Maud 
Published: July 2018

AbstractBackgroundChronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a chronic inflammatory disease often accompanied by impairment of sense of smell. This symptom has been somewhat overlooked, and its relationship to inflammatory cytokines, tissue compression, neuronal loss, and neurogenesis is still unclear.MethodsIn order to elucidate potential mechanisms leading to CRS in humans, we have established a type 2/T helper type 2 cell (Th2)‐mediated allergic CRS mouse model, based on house dust mite (HDM) and Staphylococcus aureus enterotoxin B (SEB) sensitization. The inflammatory status of the olfactory epithelium (OE) was assessed using histology, biochemistry, and transcriptomics. The sense of smell was evaluated by studying olfactory behavior and recording electro‐olfactograms (EOGs).ResultsAfter 22 weeks, a typical type 2/Th2‐mediated inflammatory profile was obtained, as demonstrated by increased interleukin (IL)‐4, IL‐5, and IL‐13 in the OE. The number of mast cells and eosinophils was increased, and infiltration of these cells into the olfactory mucosa was also observed. In parallel, transcriptomic and histology analyses indicated a decreased number of immature olfactory neurons, possibly due to decreased renewal. However, the number of mature sensory neurons was not affected and neither the EOG nor olfactory behavior was impaired.ConclusionOur mouse model of CRS displayed an allergic response to HDM + SEB administration, including the type 2/Th2 inflammatory profile characteristic of human eosinophilic CRSwNP. Although the sense of smell did not appear to be altered in these conditions, the data reveal the influence of chronic inflammation on olfactory neurogenesis, suggesting that factors unique to humans may be involved in CRSwNP‐associated anosmia.
The Value of Being Discrete: The Differential and Causal Effects of Positive Affect and Discrete Positive Emotions on Organ Donor Registration Outcomes
Authors: Blazek Danielle R. , Siegel Jason T. 
Published: July 2018

BackgroundThe current studies examined how positive affect (i.e. the blend of several positive feelings over time) and discrete positive emotions (i.e. a specific set of momentary thoughts and feelings) influence organ donor registration outcomes.MethodsIn Study 1, participants were randomly assigned to a writing task intended to elicit positive or negative affect. In Study 2, participants received a discrete positively valenced emotion induction (i.e. elevation, humor, hubristic pride), or were in a control condition.ResultsStudy 1 (N = 503) indicated a causal relationship between general positive affect and registration attitudes. An indirect effect beginning with general positive affect, going through attitudes, and then intentions, to influence behavior was also indicated. Study 2a (N = 394) demonstrated that elevation, humor, and hubristic pride can be influenced using an online platform. Study 2b (N = 1,046) indicated a causal relationship between elevation and increased registration intentions and behavior. The humor recall task caused marginally significant greater registration intentions, but no significant behavioral differences. The hubristic pride task did not influence registration outcomes.ConclusionOrgan donor practitioners and scholars could benefit from increased focus on the emotional states likely to be experienced at different venues when considering intervention contexts.
Impact of patient education on plasma concentrations and effectiveness of posaconazole oral suspension under clinical conditions
Authors: Geist Marcus J. P. , Egerer Gerlinde , Mikus Gerd , Blank Antje , Hohmann Nicolas , Heinz Werner J. , Carls Alexandra 
Published: July 2018

AbstractPosaconazole prophylaxis is recommended for patients with acute myeloid leukaemia during induction chemotherapy. Although a tablet formulation with better oral bioavailability is available, some patients have to rely on the oral suspension in clinical routine. Therefore, effectiveness of posaconazole oral suspension under real‐life clinical conditions and impact of patient education about the correct intake on its plasma concentrations were assessed in this study. Altogether 96 patients receiving 160 cycles of induction chemotherapy were retrospectively (40 patients) and prospectively (56 patients) analysed. Patients were assigned into two groups for each chemotherapy cycle according to the application of antifungal prophylaxis (A: posaconazole oral suspension, 200 mg three times a day ≥7 days; B: intake <7 days, fluconazole or no prophylaxis). Antifungal prophylaxis and therapy were analysed for each cycle. Additionally, plasma concentrations were determined from prospectively included subjects of group A who were intensively educated to perform a correct drug intake. Systemic antifungal therapy was statistically started less often in group A (26% vs 53%; P = 0.002). Posaconazole prophylaxis was associated with a lower risk of proven invasive fungal infection (P = 0.003). Median plasma concentration apparently increased between the first and second time of determination effected by an initial intensive on‐site patient education. The clinical effectiveness of posaconazole oral suspension was confirmed. A detailed patient education at the beginning of the treatment with posaconazole oral suspensions seems to be of primary importance for efficient plasma concentrations.
Endoplasmic reticulum stress and kidney dysfunction
Authors: Gallazzini Morgan , Pallet Nicolas 
Published: July 2018

AbstractChronic kidney disease (CKD) affects millions of persons worldwide and constitutes a major public health problem. Therefore, understanding the molecular basis of CKD is a key challenge for the development of preventive and therapeutic strategies. A major contributor to chronic histological damage associated with CKD is acute kidney injury (AKI). At the cellular level, kidney injuries are associated with microenvironmental alterations, forcing cells to activate adaptive biological processes that eliminate the stressor and generate alarm signals. These signalling pathways actively participate in tissue remodelling by promoting inflammation and fibrogenesis, ultimately leading to CKD. Many stresses that are encountered upon kidney injury are prone to trigger endoplasmic reticulum (ER) stress. In the kidney, ER stress both participates in acute and chronic histological damages, but also promotes cellular adaptation and nephroprotection. In this review, we will discuss the implication of ER stress in the pathophysiology of AKI and CKD progression, and we will give a critical analysis of the current experimental and clinical evidence that support ER stress as a mediator of kidney damage.
Ommochromes in invertebrates: biochemistry and cell biology
Authors: Figon Florent , Casas Jérôme 
Published: July 2018

ABSTRACTOmmochromes are widely occurring coloured molecules of invertebrates, arising from tryptophan catabolism through the so‐called Tryptophan → Ommochrome pathway. They are mainly known to mediate compound eye vision, as well as reversible and irreversible colour patterning. Ommochromes might also be involved in cell homeostasis by detoxifying free tryptophan and buffering oxidative stress. These biological functions are directly linked to their unique chromophore, the phenoxazine/phenothiazine system. The most recent reviews on ommochrome biochemistry were published more than 30 years ago, since when new results on the enzymes of the ommochrome pathway, on ommochrome photochemistry as well as on their antiradical capacities have been obtained. Ommochromasomes are the organelles where ommochromes are synthesised and stored. Hence, they play an important role in mediating ommochrome functions. Ommochromasomes are part of the lysosome‐related organelles (LROs) family, which includes other pigmented organelles such as vertebrate melanosomes. Ommochromasomes are unique because they are the only LRO for which a recycling process during reversible colour change has been described. Herein, we provide an update on ommochrome biochemistry, photoreactivity and antiradical capacities to explain their diversity and behaviour both in vivo and in vitro. We also highlight new biochemical techniques, such as quantum chemistry, metabolomics and crystallography, which could lead to major advances in their chemical and functional characterisation. We then focus on ommochromasome structure and formation by drawing parallels with the well‐characterised melanosomes of vertebrates. The biochemical, genetic, cellular and microscopic tools that have been applied to melanosomes should provide important information on the ommochromasome life cycle. We propose LRO‐based models for ommochromasome biogenesis and recycling that could be tested in the future. Using the context of insect compound eyes, we finally emphasise the importance of an integrated approach in understanding the biological functions of ommochromes.