bluuebunny/crossref_metadata_2025_split huggingface dataset:
Which observed behaviours may reassure physicians that a child is not septic? An international Delphi study
Authors: Snelson Edward , Ramlakhan Shammi 
Published: March 2018

ObjectiveIn an attempt to improve the diagnosis of sepsis in children, diagnostic aids have concentrated on clinical features that suggest that sepsis is present. Clinicians need to be able to clinically rule out sepsis as well as rule it in. Little is known about which features are consistent with wellness and/or absence of sepsis. Guidelines are therefore likely to improve sensitivity without preserving specificity. We aimed to gather expert opinion on which (if any) features would make clinicians consider a child to be unlikely to have sepsis.DesignWe undertook a modified two-round international Delphi study, where clinicians were asked for features they believed were indicators of wellness in an ill child.ParticipantsOne hundred and ninety-five clinicians (predominantly physicians) who routinely assessed unwell children and had been doing so for most of their careers.ResultsOver 90% of respondents rated age-appropriate verbalisation, playing, smiling and activity as reassuring that a child was unlikely to have sepsis. Eating, spontaneous interaction and normal movement were also agreed to be reassuring by over 70% of participants. Consolability and showing fear of the clinician were not felt to be adequately reassuring. There was wide range of opinion on how reassuring the use of an electronic device was thought to be.ConclusionsThis study confirms that physicians are reassured by specific behaviours in ill children, and provides a framework which may be used to help guide the assessment of the unwell child. Validation of individual features could lead to improved specificity of diagnostic aids for diagnosing sepsis.
Economic burden of HIV and TB/HIV coinfection in a middle-income country: a costing analysis alongside a pragmatic clinical trial in Brazil
Authors: Teixeira de Siqueira-Filha Noemia , Militao de Albuquerque Maria de Fatima , Cunha Rodrigues Laura , Legood Rosa , Costa Santos Andreia 
Published: March 2018

ObjectiveThe objective of this study was to measure the costs of people living with HIV (PLHIV) as well as active tuberculosis (TB/HIV), latent tuberculosis infection (LTBI/HIV) or without TB (HIV/AIDS).MethodsWe analysed the costs through the entire pathway of care during the prediagnosis and treatment periods from the Brazilian public health system perspective. We applied a combination of bottom-up and top-down approaches to capture and estimate direct medical and non-medical costs. We measured the mean cost per patient per type of care (inpatient, outpatient and emergency care) and disease category (HIV/AIDS, HIV/AIDS death, TB/HIV, TB/HIV death and LTBI/HIV).ResultsBetween March 2014 and March 2016 we recruited 239 PLHIV. During the follow-up 26 patients were diagnosed and treated for TB and 5 received chemoprophylaxis for LTBI. During the prediagnosis and treatment period, the mean total costs for HIV or AIDS and AIDS death categories were US$1558 and US$2828, respectively. The mean total costs for TB/HIV and TB/HIV death categories were US$5289.0 and US$8281, respectively. The mean total cost for the LTBI/HIV category was US$882.ConclusionsPatients with TB/HIV impose a higher economic burden on the health system than HIV/AIDS and LTBI/HIV. Patients with LTBI/HIV were the lowest cost group among all disease categories, indicating that preventive TB treatment can avoid the further costs treating active TB.Trial registration numberRBR-22t943, Results.
Reservoir architecture model of the Nieuwerkerk Formation (Early Cretaceous, West Netherlands Basin): diachronous development of sand-prone fluvial deposits
Authors: Vondrak A. G. , Donselaar M. E. , Munsterman D. K. 
Published: March 2018

Abstract
The sand-prone fluvial Delft Sandstone Member of the Nieuwerkerk Formation is the main target for geothermal exploitation in the West Netherlands Basin. Uncertainty reduction in the modelling of permeability heterogeneity and connectivity of the sandstone reservoir units is of prime importance in the low-profit geothermal energy market. Lithostratigraphic correlation of the Delft Sandstone Member dates back to the 1970s, and considers the fluvial deposits as Valanginian (140–134 Ma) in age and synchronously deposited throughout the basin.
Analysis of newly-acquired palynological data, in combination with well-log correlation and seismic interpretation, enabled the construction of a sequence-stratigraphic framework for the Nieuwerkerk Formation, in which the fluvial sandstones were deposited in a much wider age range than previously believed, from Late Ryazanian to Valanginian (142–134 Ma). The depocentre of fluvial deposition shifted in time from NE to SW across the width of the basin. This diachronous development resulted in a discontinuous spatial arrangement of fluvial sandstones. The new reservoir architecture model will aid in the well placement of geothermal doublets and the assessment of interference risk of adjacent geothermal projects.
Tectonostratigraphy of a rift basin affected by salt tectonics: synrift Middle Jurassic–Lower Cretaceous Dutch Central Graben, Terschelling Basin and neighbouring platforms, Dutch offshore
Authors: Bouroullec R. , Verreussel R. M. C. H. , Geel C. R. , de Bruin G. , Zijp M. H. A. A. , Kőrösi D. , Munsterman D. K. , Janssen N. M. M. , Kerstholt-Boegehold S. J. 
Published: March 2018

Abstract
The Middle Jurassic–Lower Cretaceous in the eastern Dutch offshore provides excellent examples of sand-rich sediments that locally accumulated in the vicinity of rift basin margins affected by salt tectonics. These types of deposits are often geographically restricted and difficult to identify, but can be valuable targets for hydrocarbon exploration. The distribution, thickness and preservation potential of fluvio-lacustrine, shallow- and deep-marine sediments is discussed to provide new insights into the regional and local tectonostratigraphy of the Dutch Central Graben, the Terschelling Basin and their neighbouring platforms. New sedimentological, geochemical, biostratigraphic, stratigraphic and structural information have been analysed and integrated into a new tectonostratigraphic model for the Callovian Lower Graben Formation, Oxfordian Middle and Upper Graben formations, Early–Middle Volgian Terschelling Sandstone and Noordvaarder members, and the Late Volgian–Early Ryazanian Scruff Greensand Formation. It is demonstrated that salt withdrawal at the basin axis was the primary control on the generation of high accommodation during the Callovian–Early Kimmeridgian. Incised valleys developed on the platforms providing lateral sediment input. During the Late Kimmeridgian–Ryazanian salt migration shifted laterally towards the basin margins, providing accommodation adjacent to active salt bodies and deposition of overthickened sandy strata.
Stepwise basin evolution of the Middle Jurassic–Early Cretaceous rift phase in the Central Graben area of Denmark, Germany and The Netherlands
Authors: Verreussel R. M. C. H. , Bouroullec R. , Munsterman D. K. , Dybkjær K. , Geel C. R. , Houben A. J. P. , Johannessen P. N. , Kerstholt-Boegehold S. J. 
Published: March 2018

Abstract
This paper presents the results of a cross-border study of the Middle Jurassic–Early Cretaceous rift phase in the Danish–German–Dutch Central Graben area. Based on long-distance correlations of palynologically interpreted wells, a stepwise basin evolution pattern was determined. Four phases are defined and described as tectonostratigraphic mega-sequences (TMS). The TMS are governed by changes in the tectonic regime. TMS-1 reflects the onset of rifting, triggered by regional east–west extension. Rift climax was reached during TMS-1, reflected by thick mudstone accumulations. TMS-2 reflects a change in the tectonic regime from east–west to NE–SW extension. NW–SE-trending normal faults became active during this phase, switching the depocentres from the graben axis into adjacent basins. TMS-3 displays divergent basin development. In the Dutch Central Graben area, it is characterized by a basal unconformity and widespread sandstone deposition, indicating continued salt and fault activity. Organic-rich mudstone deposition prevails in the Danish and German Central Graben area, indicating sediment starvation and water-mass stratification. With TMS-4 the rift phase ended, reflected by regionally uniform mudstone deposition. The basin evolution model presented here coherently places the lithostratigraphic units occurring in a stratigraphic framework and provides a valuable basis for hydrocarbon exploration activities in the region.
Tectonic control on the Early Cretaceous Bentheim Sandstone sediments in the Schoonebeek oil field, The Netherlands
Authors: Vis Geert-Jan , Smoor Willem D. , Rutten Kees W. , de Jager Jan , Mijnlieff Harmen F. 
Published: March 2018

Abstract
The reservoir rock of the Schoonebeek oil field is formed by the sandstones of the Bentheim Sandstone Member. The sedimentology and depositional environment of this sandstone have been extensively studied, but the relationship between the geometry of the sandstone and tectonic activity in the Schoonebeek area remains poorly understood. 355 boreholes and two three-dimensional (3D) seismic surveys were used to study this relationship. An eroded zone in the west of the field and an area where the original depositional thickness is still intact were identified. Using the ezValidator software package it can be seen that uplift of a local anticline played an important role in the erosion of the sandstone. Deposition of the sands of the Bentheim Sandstone Member and the overlying Vlieland Sandstone and Claystone formations occurred on an unstable changing palaeotopography, whereby the instability was probably driven by halokinetic movement of the underlying Late Permian Zechstein salt. Syndepositional tectonic movements affected local thickness variations in the Bentheim Sandstone Member in the west of the field, leading to westwards thinning.
Tectonic inheritance, structure reactivation and lithospheric strength: the relevance of geological history
Authors: Şengör A. M. C. , Lom Nalan , Sağdıç Nurbike G. 
Published: March 2018

Abstract
Tectonic inheritance and structure reactivation have been of interest to geologists since it was noticed in the mid-nineteenth century that younger structures in an area tend to follow the direction of older structures. Three kinds of relationship may exist between these older and younger structures: younger structures may follow the older ones and repeat their function; younger structures may follow older ones, but function in the opposite sense to the older ones; and younger structures bear no relation to the older ones. These are named, respectively, resurrected, replacement and revolutionary structures. We present three examples, on three different scales, of tectonic inheritance and structure reactivation: Mesozoic and Cenozoic Europe on a continental scale; the US Rockies on a regional scale; and the Albula Pass in the Swiss Alps on an outcrop scale. We conclude that structure reactivation on a crustal scale occurs when the protective armour of the mantle lithosphere is removed and that, in such cases, resurrected and replacement structures form. In cratons with thick lithospheric roots, structure reactivation hardly ever occurs and when, in rare cases, it does occur, it commonly generates revolutionary structures. There can be no unique model for lithospheric strength.
Metformin Suppresses Tumor Progression by Inactivating Stromal Fibroblasts in Ovarian Cancer
Authors: Xu Sen , Yang Zongyuan , Jin Ping , Yang Xin , Li Xiaoting , Wei Xiao , Wang Ya , Long Sixiang , Zhang Taoran , Chen Gang , Sun Chaoyang , Ma Ding , Gao Qinglei 
Published: March 2018

Abstract
Ovarian cancer is a devastating disease due to its high incidence of relapse and chemoresistance. The tumor microenvironment, especially the tumor stroma compartment, was proven to contribute tremendously to the unsatisfactory chemotherapeutic efficacy in ovarian cancer. Cytotoxic agents not only effect tumor cells, but also modulate the phenotype and characteristics of the vast stromal cell population, which can in turn alter the tumor cell response to chemointervention. In this study, we focused on the tumor stroma response to cytotoxic agents and the subsequent effect on the ovarian cancer tumor cells. First, we found a significant stromal overexpression of IL6 in patient samples that received cisplatin-based treatment, which was further validated in purified fibroblasts challenged with cisplatin. Stromal fibroblast–derived IL6 was proven to mediate ovarian cancer tumor cell chemoresistance. For the first time, we found that the tumor stroma of patients with routine metformin administration exhibited lower IL6 expression. Thus, we presumed that metformin was a potent alleviator of stromal inflammation in ovarian cancer. We found that metformin partly reversed cisplatin-stimulated IL6 secretion in the stromal fibroblasts and attenuated fibroblast-facilitated tumor growth in 3D organotypic cocultures and murine xenograft models. Mechanistically, we found that metformin inhibited IL6 secretion via suppressing NFκB signaling, an upstream controller of stromal inflammation. Collectively, our findings introduced a novel mechanism of metformin in suppressing ovarian cancer progression through diminishing chemotherapy-induced stromal activation. Therefore, we provide an alternative therapeutic option in targeting stromal inflammation and a potential scheme of combination therapy to improve the chemosensitivity in ovarian cancer. Mol Cancer Ther; 17(6); 1291–302. ©2018 AACR.
Inhibition of Glycolysis in Prostate Cancer Chemoprevention by Phenethyl Isothiocyanate
Authors: Singh Krishna B. , Hahm Eun-Ryeong , Rigatti Lora H. , Normolle Daniel P. , Yuan Jian-Min , Singh Shivendra V. 
Published: March 2018

Abstract
We have shown previously that dietary administration of phenethyl isothiocyanate (PEITC), a small molecule from edible cruciferous vegetables, significantly decreases the incidence of poorly differentiated prostate cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice without any side effects. In this study, we investigated the role of c-Myc–regulated glycolysis in prostate cancer chemoprevention by PEITC. Exposure of LNCaP (androgen-responsive) and 22Rv1 (castration-resistant) human prostate cancer cells to PEITC resulted in suppression of expression as well as transcriptional activity of c-Myc. Prostate cancer cell growth inhibition by PEITC was significantly attenuated by stable overexpression of c-Myc. Analysis of the RNA-Seq data from The Cancer Genome Atlas indicated a significant positive association between Myc expression and gene expression of many glycolysis-related genes, including hexokinase II and lactate dehydrogenase A. Expression of these enzyme proteins and lactate levels were decreased upon PEITC treatment in prostate cancer cells, and these effects were significantly attenuated by ectopic expression of c-Myc. A normal prostate stromal cell line (PrSC) was resistant to lactic acid suppression by PEITC treatment. Prostate cancer chemoprevention by PEITC in TRAMP mice was associated with a significant decrease in plasma lactate and pyruvate levels. However, a 1-week intervention with 10 mg PEITC (orally, 4 times/day) was not sufficient to decrease lactate levels in the serum of human subjects. These results indicated that although prostate cancer prevention by PEITC in TRAMP mice was associated with suppression of glycolysis, longer than 1-week intervention might be necessary to observe such an effect in human subjects. Cancer Prev Res; 11(6); 337–46. ©2018 AACR.
ЕПІДЕМІОЛОГІЧНІ ТА КЛIНIЧНІ АСПЕКТИ НАСЛІДКІВ ЧЕРЕПНО-МОЗКОВОЇ ТРАВМИ
Authors: Chernenko I. I. , Сhukhno I. A. 
Published: March 2018

Мета: провести дослідження поширеності черепно-мозкової травми та її основних наслідків на основі вивчення літературних джерел, їх впливу на якість життя хворих, соціальну значимість цих наслідків з урахуванням розповсюдженості патології.Матеріали і методи. У дослідженні використовували бібліосемантичний та аналітичний методи, метод наукового абстрагування. Були досліджені статистичні дані та наукові публікації щодо розповсюдженості та наслідків черепно-мозкових травм, їх віддалених наслідків та особливостей реабілітації. Результати. Проведений аналіз розповсюдженості черепно-мозкових травм, їх віддалених наслідків дозволяють констатувати зростання значимості цієї проблеми на сучасному етапі розвитку держави, а їх вплив на якість життя хворих, складнощі в їх подальшій соціальній адаптації щодо зростання медико-соціальної значимості цієї проблеми. Висновки. Внаслідок зростання кількості військових конфліктів у світі та розвиток військових технологій спостерігається тенденція до зростання кількості черепно-мозкових травм. Удосконалення підходів до лікування цих травм дозволило збільшити рівень виживання хворих, проте, внаслідок цього, зросла і медико-соціальна значимість удосконалення системи лікування віддалених їх наслідків, що внаслідок значного рівня неврологічних, когнітивних та адаптаційних порушень, мають значний негативний вплив на якість життя хворих та їх оточення, викликаючи негативні соціальні наслідки для суспільства в цілому.
MJO Prediction Skill of the Subseasonal-to-Seasonal Prediction Models
Authors: Lim Yuna , Son Seok-Woo , Kim Daehyun 
Published: March 2018

Abstract
The Madden–Julian oscillation (MJO), the dominant mode of tropical intraseasonal variability, provides a major source of tropical and extratropical predictability on a subseasonal time scale. This study conducts a quantitative evaluation of the MJO prediction skill in state-of-the-art operational models, participating in the subseasonal-to-seasonal (S2S) prediction project. The relationship of MJO prediction skill with model biases in the mean moisture fields and in the longwave cloud–radiation feedbacks is also investigated.
The S2S models exhibit MJO prediction skill out to a range of 12 to 36 days. The MJO prediction skills in the S2S models are affected by both the MJO amplitude and phase errors, with the latter becoming more important at longer forecast lead times. Consistent with previous studies, MJO events with stronger initial MJO amplitude are typically better predicted. It is found that the sensitivity to the initial MJO phase varies notably from model to model.
In most models, a notable dry bias develops within a few days of forecast lead time in the deep tropics, especially across the Maritime Continent. The dry bias weakens the horizontal moisture gradient over the Indian Ocean and western Pacific, likely dampening the organization and propagation of the MJO. Most S2S models also underestimate the longwave cloud–radiation feedbacks in the tropics, which may affect the maintenance of the MJO convective envelope. The models with smaller bias in the mean horizontal moisture gradient and the longwave cloud–radiation feedbacks show higher MJO prediction skills, suggesting that improving those biases would enhance MJO prediction skill of the operational models.
The Tropospheric Pathway of the ENSO–North Atlantic Teleconnection
Authors: Jiménez-Esteve Bernat , Domeisen Daniela I. V. 
Published: March 2018

Abstract
El Niño–Southern Oscillation (ENSO) exerts an influence on the North Atlantic–European (NAE) region. However, this teleconnection is nonlinear and nonstationary owing to the superposition and interaction of a multitude of influences on this region. The stratosphere is one of the major players in terms of the influence of the ENSO signal on this sector. Nevertheless, there are tropospheric dynamical links between the North Pacific and the North Atlantic that are clearly influenced by ENSO. This tropospheric pathway of ENSO to the NAE has received less attention. In view of this, the present study revisits the tropospheric pathway of ENSO to the North Atlantic using ECMWF reanalysis products. Anomalous propagation of transient and quasi-stationary waves across North America is analyzed with respect to their sensitivity to ENSO. Transient (quasi-stationary zonal waves 1–3) wave activity flux (WAF) from the Pacific to the Atlantic increases during El Niño (La Niña) conditions leading to a negative (positive) phase of the North Atlantic Oscillation (NAO). This response is observed from January to March for El Niño and only visible during February for La Niña events. However, the stratosphere strongly modulates this response. For El Niño (La Niña) conditions a weaker (stronger) stratospheric vortex tends to reinforce the negative (positive) NAO with the stratosphere and troposphere working in tandem, contributing to a stronger and more persistent tropospheric circulation response. These findings may have consequences for the prediction of the NAO during times with an inactive stratosphere.
Violent offending in schizophrenia spectrum disorders preceding and following diagnosis
Authors: Hachtel Henning , Harries Cieran , Luebbers Stefan , Ogloff James RP 
Published: March 2018

Objective: People affected by schizophrenia spectrum disorders are at a higher risk of offending violently. This study aims to investigate risk factors in relation to the peri-diagnostic period and possible predictors of post-diagnostic violence of people diagnosed for the first time in the public mental health system. Methods: The study compared various risk factors for post-diagnostic violence in patients ( n = 1453) diagnosed with a schizophrenia spectrum disorder. Patients were grouped according to the occurrence of peri-diagnostic violence. Of the 246 violent offenders, 164 committed their first offence pre-diagnosis. Mental health and criminological variables were evaluated across the lifespan (median age at end of follow-up = 34.22 years, range = 17.02–55.80 years). Results: Gender, employment, non-violent offending, family incidents, violent and non-violent victimisation, substance use, personality disorder, number of in-patient admissions and history of non-compliance differed significantly across violent and non-violent subgroups (all p ⩽ 0.01 and at least small effect size). More frequent and longer inpatient admissions were found in the violent subgroups (all p ⩽ 0.01). For the whole sample, sex, number of violent offences, non-violent offences, violent victimisation, substance use and number of inpatient admissions predicted post-diagnostic violence (χ2 (6) = 188.13, p < 0.001). Among patients with a history of pre-diagnostic violence, a history of non-violent offending in the 18-month period pre-diagnosis was the strongest predictor of future violence (odds ratio = 3.08, 95% confidence interval [1.32, 7.21]). Conclusion: At triage, violence risk assessment should consider the presence of antisocial behaviour and violent victimisation, substance use, male gender and frequency of inpatient admissions. Common treatment targets for the prevention of post-diagnostic violence include criminality and victimisation. Treatment of positive symptoms should be of greater emphasis for individuals without a history of pre-diagnostic violence.