bluuebunny/crossref_metadata_2025_split huggingface dataset:
An adaptive clinical decision support system for serving the elderly with chronic diseases in healthcare industry
Authors: Tang Valerie , Siu Paul Kai Yuet , Choy King Lun , Lam Hoi Yan , Ho George To Sum , Lee Carman Ka Man , Tsang Yung Po 
Published: January 2019

AbstractWith the increasing ageing population worldwide, providing effective nursing care planning in nursing homes is important in meeting the expectations of elderly patients and in streamlining the healthcare information process, hence maintaining high‐quality services. Instead of the traditional manual nursing care planning formulation based on expert experience and subjective judgement, this paper describes an adaptive decision support system, namely, the cloud‐based nursing care planning system, to enable decision making in formulating nursing care strategies. By integrating cloud computing technology and the case‐based reasoning (CBR) technique, medical records and documents pertaining to the elderly can be captured in real time, whereas appropriate treatment plans based on past similar treatment records can be formulated. However, the current case adaptation processes in CBR rely on domain experts to modify retrieved cases, which may not satisfy the needs of the elderly. Therefore, text mining is integrated in the case adaptation process of CBR for extracting up‐to‐date medical information from the Internet so that its efficiency can be improved. By conducting a pilot study in a nursing home, it was shown that the time for formulating applicable treatment plans for elderly patients can be reduced, and the service satisfaction level can be enhanced.
A Multifaceted and Dyadic Examination of Intimate Relationship Quality during Pregnancy: Implications for Global Relationship Satisfaction
Authors: Ramsdell Erin L. , Franz Molly , Brock Rebecca L. 
Published: January 2019

Understanding how couples navigate and negotiate the challenges and demands of pregnancy has important implications for family health. The aim of this study was to apply a multidimensional model of intimate relationship quality in a sample of 154 pregnant, cohabitating couples, to investigate the association between a range of intimate relationship processes (i.e., emotional intimacy, conflict management, sexual quality, received respect and acceptance, and received support) and the global relationship satisfaction of each partner. Semistructured clinical interviews were administered to each partner assessing multiple qualities of the relationship, and participants completed home surveys of global relationship satisfaction each day for 14 days. Results demonstrated that multiple dimensions of the intimate relationship were associated with greater relationship satisfaction. Some processes (e.g., degree of emotional intimacy and closeness, conflict management) had larger effects on relationship satisfaction than others (e.g., quality of the sexual relationship). Furthermore, some processes were more important for maternal than paternal satisfaction (e.g., emotional intimacy, support, respect). Finally, results varied, to some degree, as a function of whether parents were transitioning to parenthood for the first time. We discuss the implications of adopting a multidimensional approach to studying the specific relationship processes associated with global relationship satisfaction and present implications for clinicians working with couples navigating the transition into parenthood.
The Effect of Undetected Barriers on Groundwater Drawdown and Recovery
Authors: Marshall Sarah K. , Cook Peter G. , Miller Anthony D. , Simmons Craig T. , Dogramaci Shawan 
Published: January 2019

AbstractIn large‐scale pumping projects, such as mine dewatering, predictions are often made about the rate of groundwater level recovery after pumping has ceased. However, these predictions may be impacted by geological uncertainty—including the presence of undetected impermeable barriers. During pumping, an impermeable barrier may be undetected if it is located beyond the maximum extent of the cone of depression; yet it may still control drawdown during the recovery phase. This has implications for regional‐scale modeling and monitoring of groundwater level recovery. In this article, non‐dimensional solutions are developed to show the conditions under which a barrier may be undetected during pumping but still significantly impact groundwater level recovery. The magnitude of the impact from an undetected barrier will increase as the ratio of pumping rate to aquifer transmissivity increases. The results are exemplified for a hypothetical aquifer with an unknown barrier 3 km from a pumping well. The difference in drawdown between a model with and without a barrier may be <1 m in the 10 years while pumping is occurring, but up to 50 m after pumping has ceased.
Leaky Aquifer Models to Simulate the Well Flow in Fractured Aquifers with Linear Interporosity Flow
Authors: Székely Ferenc , Szűcs Péter , Zákányi Balázs 
Published: January 2019

AbstractFollowing Hemker and Maas (1987) the models of two or three leaky aquifers are applied to simulate the flow to vertical wells operating in the fractured or dual porosity aquifers. The software WellTest (WT) (Székely 2015) is used for calculating the drawdown and discharge rate variation. The comparative analysis with the independent analytical solutions by Boulton and Streltsova‐Adams (1978), Warren and Root (1963), Kazemi et al. (1969) concluded with acceptable agreement between the WT simulation and the alternate calculation methods. The selected field tests have been conducted in fractured limestone aquifers. The pumping test west of Copenhagen shows an example of fractured aquifer with considerable negative skin effect at the well face. The flowing well Wafra W1 in Kuwait operates in the two‐zone aquifer exhibiting sufficient vertical recharge via leakage beyond a circular domain of estimated radius of 2460 m.
Netrin‐1 alleviates subarachnoid haemorrhage‐induced brain injury via the PPARγ/NF‐KB signalling pathway
Authors: Chen Junhui , Xuan Yong , Chen Yan , Wu Ting , Chen Lei , Guan Haoxiang , Yang Shuo , He Jianqing , Shi Dongliang , Wang Yuhai 
Published: January 2019

AbstractNetrin‐1 (NTN‐1) is a novel drug to alleviate early brain injury following subarachnoid haemorrhage (SAH). However the molecular mechanism of NTN‐1‐mediated protection against early brain injury following SAH remains largely elusive. This study aims to evaluate the effects and mechanisms of NTN‐1 in protecting SAH‐induced early brain injury. The endovascular perforation SAH model was constructed using male C57BL/6J mice, and recombinant NTN‐1 was administrated intravenously. Mortality rates, SAH grade, brain water content, neurological score and neuronal apoptosis were evaluated. The expression of PPARγ, Bcl‐2, Bax and nuclear factor‐kappa B (NF‐κB) were detected by Western blot. Small interfering RNA specific to NTN‐1 receptor, UNC5B, and a selective PPARγ antagonist, bisphenol A diglycidyl ether (BADGE), were applied in combination with NTN‐1. The results suggested that NTN‐1 improved the neurological deficits, reduced the brain water content and alleviated neuronal apoptosis. In addition, NTN‐1 enhanced PPARγ and Bcl‐2 expression and decreased the levels of Bax and NF‐κB. However, the neuroprotection of NTN‐1 was abolished by UNC5B and BADGE. In conclusion, our results demonstrated that NTN‐1 attenuates early brain injury following SAH via the UNC5B PPARγ/NF‐κB signalling pathway.
Histone demethylase KDM7A reciprocally regulates adipogenic and osteogenic differentiation via regulation of C/EBPα and canonical Wnt signalling
Authors: Yang Xiaoyue , Wang Guannan , Wang Yi , Zhou Jie , Yuan Hairui , Li Xiaoxia , Liu Ying , Wang Baoli 
Published: January 2019

AbstractRecent emerging evidences revealed that epigenetic methylation of histone and DNA regulates the lineage commitment of mesenchymal progenitor cells. This study was undertaken to delineate the actions of histone lysine demethylase 7A (KDM7A) on osteogenic and adipogenic differentiation. Kdm7a expression was up‐regulated in primary marrow stromal cells and established stromal ST2 line after adipogenic and osteogenic treatment. Silencing of endogenous Kdm7a in the cells blocked adipogenic differentiation whereas promoted osteogenic differentiation. Conversely, overexpression of wild‐type Kdm7a in the progenitor cells enhanced adipogenic differentiation whereas inhibited osteogenic differentiation. However, the effect of KDM7A on cell differentiation was largely attenuated when the point mutation was made that abolishes enzymatic activity of KDM7A. Mechanism investigations revealed that silencing of Kdm7a down‐regulated the expression of the CCAAT/enhancer binding protein α (C/EBPα) and secreted frizzled‐related protein 1 (Sfrp1). Chromatin immunoprecipitation (ChIP) assay revealed that KDM7A directly binds to the promoters of C/EBPα and Sfrp1 and removes the histone methylation marks H3K9me2 and H3K27me2. Furthermore, silencing of Kdm7a activated canonical Wnt signalling. Thereafter, activation of canonical Wnt signalling through silencing of Sfrp1 in ST2 attenuated the stimulation of adipogenic differentiation and inhibition of osteogenic differentiation by KDM7A. Our study suggests that KDM7A balances adipogenic and osteogenic differentiation from progenitor cells through epigenetic control of C/EBPα and canonical Wnt signalling and implicates that control of KDM7A action has an epigenetic perspective of curtailing metabolic disorders like osteoporosis.
Genetic association with high‐resolution climate data reveals selection footprints in the genomes of barley landraces across the Iberian Peninsula
Authors: Contreras‐Moreira Bruno , Serrano‐Notivoli Roberto , Mohammed Naheif E. , Cantalapiedra Carlos P. , Beguería Santiago , Casas Ana M. , Igartua Ernesto 
Published: January 2019

AbstractLandraces are local populations of crop plants adapted to a particular environment. Extant landraces are surviving genetic archives, keeping signatures of the selection processes experienced by them until settling in their current niches. This study intends to establish relationships between genetic diversity of barley (Hordeum vulgare L.) landraces collected in Spain and the climate of their collection sites. A high‐resolution climatic data set (5 × 5 km spatial, 1‐day temporal grid) was computed from over 2,000 temperature and 7,000 precipitation stations across peninsular Spain. This data set, spanning the period 1981–2010, was used to derive agroclimatic variables meaningful for cereal production at the collection sites of 135 barley landraces. Variables summarize temperature, precipitation, evapotranspiration, potential vernalization and frost probability at different times of the year and time scales (season and month). SNP genotyping of the landraces was carried out combining Illumina Infinium assays and genotyping‐by‐sequencing, yielding 9,920 biallelic markers (7,479 with position on the barley reference genome). The association of these SNPs with agroclimatic variables was analysed at two levels of genetic diversity, with and without taking into account population structure. The whole data sets and analysis pipelines are documented and available at https://eead-csic-compbio.github.io/barley-agroclimatic-association. We found differential adaptation of the germplasm groups identified to be dominated by reactions to cold temperature and late‐season frost occurrence, as well as to water availability. Several significant associations pointing at specific adaptations to agroclimatic features related to temperature and water availability were observed, and candidate genes underlying some of the main regions are proposed.
Understanding the pathophysiology behind chairside diagnostics and genetic testing for IL‐1 and IL‐6
Authors: Rudick Courtney P. , Lang Melissa S. , Miyamoto Takanari 
Published: January 2019

AbstractIn order for chairside diagnostic testing to make an impact on dental therapy, practitioners require a better understanding of genetic mutations contributing to the pathophysiology of periodontal disease. Commensal and pathogenic bacterial colonization in oral cavity tissues produces a cascade of proinflammatory signaling pathways ultimately detrimental to host tissues. Resolving inflammation is a multifactorial process involving the downregulation of proinflammatory cytokines while allowing commensal bacterial levels to return to normal. Because of the complicated nature of commensal bacteria and oral health homeostasis, the emphasis of dental therapy should place renewed focus on limiting destructive inflammation rather than solely eliminating bacteria. Salivary diagnostics are an easy, non‐invasive way to assess inflammatory markers. Inflammatory cytokine levels can help determine the subclinical health of a patient, showing the transition from health to gingivitis, or periodontitis, prior to clinical presentation. Single nucleotide polymorphism mutations can aid in determining increased risk of developing periodontitis. Taken together, and alongside regular clinical evaluations, chairside diagnostics help individualize treatment plans to slow, or halt, the progression of disease—before tissue destruction can take place. While more studies are needed analyzing specific mutations across periodontal categories, chairside diagnostics present an exciting adjunct to improve patient care.
Curcumin, a turmeric extract, for oral lichen planus: A systematic review
Authors: White C. Michael , Chamberlin Kevin , Eisenberg Ellen 
Published: January 2019

AbstractObjectiveConduct a PROSPERO registered (CRD42018105227) systematic review of the efficacy of curcumin in the treatment of oral lichen planus (OLP).Data sourcesMedline from the earliest possible date to the present (December 18, 2018) using the terms “turmeric” OR “curcumin” OR “curcuma“ AND “oral lichen planus“.Study selection and data extractionStudies assessing patient outcomes in OLP. There were four trials assessing the comparative efficacy of topical curcumin vs. topical corticosteroids and three trials assessing the efficacy of oral curcumin vs. placebo.Data synthesisClinical and methodological heterogeneity precluded statistical pooling. There were many limitations in the literature weakening the strength and applicability of evidence. Topical curcumin provided reductions in pain, burning, and clinical manifestations of OLP versus baseline, effects similar or inferior to topical corticosteroids. In oral curcumin trials, there were no significant benefits of curcumin therapy versus placebo but there were some potential benefits and reasonable safety in an observational extension study.ConclusionsIt is difficult to determine whether topical or oral curcumin is a viable therapy for oral lichen planus. Topically applied curcumin in particular shows promising preliminary data but would likely not supplant topical corticosteroids as the modality of choice for most patients.
Follicular dynamics and colour Doppler vascularity evaluations of follicles and corpus luteum in relation to plasma progesterone during the oestrous cycle of Surti buffaloes
Authors: Gaur Mitesh , Purohit Govind Narayan 
Published: January 2019

ContentsWith an objective to evaluate the follicular dynamics and vascularity changes in follicles and corpus luteum, the ovaries of cyclic Surti buffaloes (n = 9) were examined daily sequentially by transrectal B‐mode and colour flow mode (CFM) ultrasonography starting from the day of oestrus till the onset of next oestrus. Higher proportion of buffaloes evidenced one‐wave cycle (66.66%) compared to two‐wave cycle (33.34%) with none showing a three‐wave cycle. The dominant follicle of the first follicular wave was the ovulatory follicle and persisted for 19.70 ± 0.50 days compared to its persistence for 16.5 ± 1.45 days in a two‐wave cycle. The maximum diameter of the ovulatory follicle in a one‐wave and two‐wave cycle did not differ yet their linear growth rates were significantly lower (p < 0.01) in a one‐wave cycle. Colour flow mode examination of follicles revealed that the percentage of follicles with detectable blood flow in the subsequently determined largest follicle (dominant follicle) was not different from that in the second largest follicle before follicle deviation. The blood flow in the dominant follicle increased significantly on the day of oestrus. The mean diameter and blood flow to the corpus luteum (CL) increased linearly and significantly from Day 5 of oestrus till Day 13 after which both parameters started declining. At or around Day 16, there was precipitous fall in the blood supply to the CL and CL diameter that continued declining thereafter to reach the lowest around Day 20 of the oestrous cycle. Rise in plasma progesterone concentrations was synchronous to CL diameter and vascularity and showed significant and positive correlations. It was concluded that Surti buffaloes evidence a preponderance of one‐wave follicular growth pattern with a significant increase in the vascularity of ovulatory follicle on the day of oestrus and corpus luteum on Day 13 of the oestrous cycle.
Computational multivariate modelling of electrical activity of the porcine uterus during spontaneous and hormone‐induced oestrus
Authors: Domino Malgorzata , Domino Krzysztof , Pawlinski Bartosz , Sady Maria , Gajewska Magdalena , Gajewski Zdzislaw 
Published: January 2019

New Findings
What is the central question of this study?
Does oestrous cycle synchronization influence myoelectrical activity of porcine myometrium?

What is the main finding and its importance?
Exogenous hormones used to synchronize oestrus in pigs altered myoelectrical activity, which was effectively modelled. Higher‐order multivariate statistic modelling provided evidence of similar activity in both types of oestrus, but a larger order of EMG signals during induced oestrus. Higher‐order statistical analysis of the probabilistic model suggests the beginning of the early follicular phase and the mid‐luteal phase to be most important in evaluation of the natural patterns of myoelectrical activity. Higher‐order multivariate cumulants are more informative than classical statistics in characterization of myoelectrical activity changes in porcine myometrium.

AbstractIn pig production units, control of the oestrous cycle and synchronization of ovulation have become routine herd management procedures. During the oestrous cycle, in both induced and spontaneous conditions, the ovaries and the uterus undergo hormone‐dominated physiological changes, which are consistent with the hypothesis that there is a functional role of uterine contractions in promoting fertilization. We have used electromyography to determine whether the use of exogenous hormones, such as equine chorionic gonadotrophin and human chorionic gonadotrophin, which have the potential to control the timing of ovulation in female pigs, changes the multivariate relationships between parameters of electrical bursts and modulates the patterns of myoelectrical activity. We used the mathematical approach of higher‐order multivariate cumulants in complex modelling of the myometrial electrical activity. The experiment was conducted on 12 mature Polish Landrace sows, and uterine activity was recorded during both spontaneous and induced oestrous cycles. The burst parameters were determined using six features in the time domain and, after Fast Fourier transformation, in the frequency domain. Evaluation of myoelectrical activity patterns was conducted based on classical univariate statistical methods and multivariate probabilistic modelling. The classical statistical approach indicated weaker myoelectrical activity after hormonal stimulation, whereas the higher‐order multivariate statistical model showed evidence of similar status of activity and a larger order of signals during induced oestrus. Routine oestrous cycle synchronization affects the multivariate probabilistic model of myometrial electrical activity.
Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load
Authors: Schuch Anita , Salimi Alizei Elahe , Heim Kathrin , Wieland Dominik , Kiraithe Michael Muthamia , Kemming Janine , Llewellyn-Lacey Sian , Sogukpinar Özlem , Ni Yi , Urban Stephan , Zimmermann Peter , Nassal Michael , Emmerich Florian , Price David A , Bengsch Bertram , Luxenburger Hendrik , Neumann-Haefelin Christoph , Hofmann Maike , Thimme Robert 
Published: January 2019

ObjectiveA hallmark of chronic HBV (cHBV) infection is the presence of impaired HBV-specific CD8+ T cell responses. Functional T cell exhaustion induced by persistent antigen stimulation is considered a major mechanism underlying this impairment. However, due to their low frequencies in chronic infection, it is currently unknown whether HBV-specific CD8+ T cells targeting different epitopes are similarly impaired and share molecular profiles indicative of T cell exhaustion.DesignBy applying peptide-loaded MHC I tetramer-based enrichment, we could detect HBV-specific CD8+ T cells targeting epitopes in the HBV core and the polymerase proteins in the majority of 85 tested cHBV patients with low viral loads. Lower detection rates were obtained for envelope-specific CD8+ T cells. Subsequently, we performed phenotypic and functional in-depth analyses.ResultsHBV-specific CD8+ T cells are not terminally exhausted but rather exhibit a memory-like phenotype in patients with low viral load possibly reflecting weak ongoing cognate antigen recognition. Moreover, HBV-specific CD8+ T cells targeting core versus polymerase epitopes significantly differed in frequency, phenotype and function. In particular, in comparison with core-specific CD8+ T cells, a higher frequency of polymerase-specific CD8+ T cells expressed CD38, KLRG1 and Eomes accompanied by low T-bet expression and downregulated CD127 indicative of a more severe T cell exhaustion. In addition, polymerase-specific CD8+ T cells exhibited a reduced expansion capacity that was linked to a dysbalanced TCF1/BCL2 expression.ConclusionsOverall, the molecular mechanisms underlying impaired T cell responses differ with respect to the targeted HBV antigens. These results have potential implications for immunotherapeutic approaches in HBV cure.