bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Fluctuating Extreme Temperatures on Tranexamic Acid
Authors: Loner Carly , Estephan Michael , Davis Hillary , Cushman Jeremy T. , Acquisto Nicole M. 
Published: May 2019

AbstractIntroduction:Tranexamic acid (TXA) is an antifibrinolytic agent shown to reduce morbidity and mortality in hemorrhagic shock. It has potential use in prehospital and wilderness medicine; however, in these environments, TXA is likely to be exposed to fluctuating and extreme temperatures. If TXA degrades under these conditions, this may reduce antifibrinolytic effects.Problem:This study sought to determine if repetitive temperature derangement causes degradation of TXA.Methods:Experimental samples underwent either seven days of freeze/thaw or heating cycles and then were analyzed via mass spectrometry for degradation of TXA. An internal standard was used for comparison between experimental samples and controls. These samples were compared to room temperature controls to determine if fluctuating extreme temperatures cause degradation of TXA.Results:The coefficient of variability of ratios of TXA to internal standard within each group (room temperature, freeze, and heated) was less than five percent. An independent t-test was performed on freeze/thaw versus control samples (t = 2.77; P = .17) and heated versus control samples (t = 2.77; P = .722) demonstrating no difference between the groups.Conclusion:These results suggest that TXA remains stable despite repeated exposure to extreme temperatures and does not significantly degrade. These findings support the stability of TXA and its use in extreme environments.
Cognitive behaviour therapy for psychosis
Authors: Kuipers Elizabeth , Bebbington Paul 
Published: May 2019

SummaryAims– It used to be thought that the problems of psychosis were qualitatively difference from those of other disorders and therefore unamenable to psychological interventions. However more recent evidence will be summarised which suggests otherwise.Methods– A cognitive model of the positive symptoms of psychosis (Garety et al, 2001; Kuipers et al.,2006) is described which builds on work on the dimensions of symptoms of psychosis, the continuum between non-clinical and clinical populations, and the contribution of emotional processes, cognitive reasoning biases and social factors.Results– Evidence from both epidemiological and empirical studies from our research group and others, support some of the pathways of symptom formation and maintenance proposed by the model. Specifically there is evidence for the role of trauma, social adversity and stress. These may trigger emotional responses and unusual experiences and together with reasoning biases lead to appraisals that can be defined as positive symptoms such as delusions and hallucinations. Similar processes interact to maintain symptoms.Conclusions– Cognitive models of psychosis have led to the development of cognitive behavioural treatments for delusions and hallucinations, which show some evidence of efficacy. Such treatments need to be refined in the light of recent research.Declaration of Interest: none
Identification and management of depression in primary care settings. A meta-review of evidence
Authors: Barbui Corrado , Tansella Michele 
Published: May 2019

SummaryAim– The purpose of this review is to summarize the evidence base on the effectiveness of (a) screening for depression in primary care; (b) managing depression in primary care employing specific management strategies; (c) treating primary care depressive patients with antidepressants.Methods– Meta-review of all available reviews of the evidence.Results– Screening alone does not improve the recognition, management and outcome of depression in primary care settings. Management strategies, including (a) training primary care staff, (b) consultation-liaison, (c) collaborative care, (d) replacement/referral are supported by insufficient evidence to provide a definite answer as to the clinical effectiveness of individual models. Robust evidence exists to encourage physicians to prescribe effective doses of antidepressants in patients with moderate to severe depression who seek treatment in primary care settings.Conclusion– Population-level screening campaigns have a negative ratio of costs to benefits. However, at an individual-level of care increasing the ability of primary care physicians in recognising depression remains a relevant factor. Primary care physicians should consider whether depression is mild, moderate or severe. This patient categorisation help develop appropriate management and therapeutic strategies.Declaration of Interest: none
Socio-economic status and geographies of psychiatric inpatient service use. Places, provision, power and wellbeing
Authors: Curtis Sarah 
Published: May 2019

AbstractThis editorial briefly summarises some aspects of research on socio-economic status and use of mental health services that have particular relevance for the theme of this issue of Epidemiologia e Psichiatria Sociale. This discussion takes a view from the perspective of health geography, which examines how the relationships between individuals and their social and physical environment result in variations in health and health care use. Three particular issues are considered here. First, the geographical distribution and organisation of psychiatric services may interact with social and economic factors in ways that are important for service use. Second, increasingly sophisticated ecological modelling strategies have elucidated the associations between socio-economic factors and service use at the population level. Third, more intensive, qualitative research complements these statistical analyses and encouraged reflection on the socio-economic processes, within psychiatric care settings, as well as in wider society, which influence service use.
Privacy, Cybersecurity, and GATS Article XIV: A New Frontier for Trade and Internet Regulation?
Authors: Mishra Neha 
Published: May 2019

AbstractMeasures restricting data flows outside one's borders, including mandatory data/server localization measures, are not only a barrier to trade, but also largely ineffective in achieving better internet security or trust. Nevertheless, governments deploy such measures, primarily on grounds of cybersecurity and privacy, potentially violating their obligations under the General Agreement on Trade in Services (GATS). In this article, I investigate whether GATS-inconsistent measures may be justified under GATS Art. XIV when aimed at ensuring privacy or cybersecurity, and, if so, whether GATS Art. XIV effectively balances trade and internet policy. As the internet governance framework is complex and somewhat ambiguous, applying GATS Art. XIV to cybersecurity/privacy measures necessitates balancing of trade liberalization principles and domestic internet policy. This exercise can be effective in weeding out data localization measures disguised as privacy/cybersecurity measures, particularly by employing relevant technical and factual evidence. However, given the lack of binding international law/norms on these issues, GATS Art. XIV has a limited role, particularly in cases involving direct conflict between multistakeholder/transnational internet norms and domestic internet policies, or where the measures are founded on contentious standards/benchmarks on privacy/cybersecurity. Ultimately, ensuring free and secure data flows requires a multidimensional policy response, including strengthening linkages between trade law and internet governance.
Childhood Victimization by Adults and Peers and Health-Risk Behaviors in Adulthood
Authors: Cerezo M. Ángeles , Pérez-García Elena 
Published: May 2019

AbstractVictimization experienced in childhood has been linked with health-risk behaviors (HRBs) in adulthood. The purpose of this cross-sectional survey was to provide data regarding the HRBs using the ISPCAN Child Abuse Screening Tool Retrospective version (ICAST-R), Spanish version. This aimed to broaden existing knowledge by assessing both being victimized by adults and by peers in a Spanish general population of 348, aged 18–35. Age and timing of the reported victimization were also considered. Victimization: physical, psychological, sexual abuse by adults and/or peers showed a prevalence of 44.54%. Of these, 41.29% reported abuse by both. Children victimized by adults, regardless of type, were significantly associated to be psychologically abused by their peers (p < .001). Moreover, psychological maltreatment by adults was significantly associated with two peer victimizations: Physical and psychological (p < .001 in both). Regarding HRBs, peer victimized groups showed significantly higher levels of severity than non-victimized, with a higher proportion reporting attempted suicide (p < .05) and psychological or psychiatric treatment (p < .05). Participants victimized only by adults reported higher number of HRBs (p < .01), their victimization was associated to more severe abuse of drugs/alcohol (p ≤ .05), and suicide attempts (p < .05). Those victimized by adults and peers received treatment in higher proportion than non-victims (p < .001). Participants reporting victimization since before 5 years to age of 17, compared with non-victimized, showed more substance abuse (p < .05), attempted suicide (p < .01) and receipt of treatment (p < .05). These findings highlight the relevance of ICAST-R in studying HRBs.
Remote Western Arctic Nutrients Fuel Remineralization in Deep Baffin Bay
Authors: Lehmann N. , Kienast M. , Granger J. , Bourbonnais A. , Altabet M. A. , Tremblay J.‐É. 
Published: May 2019

AbstractThe oceanic nitrogen cycle is critically important for the partitioning of greenhouse gases between ocean and atmosphere. Baffin Bay connects ocean regions that are major sources (North Atlantic) and sinks (North Pacific and western Arctic) of biologically available nitrogen and further harbors supersaturation of nitrous oxide and a coincident deficit in nitrate in the deep basin. Isotopic tracer profiles of both nitrogen species presented here provide novel insights into the origin and cycling of reactive nitrogen in Baffin Bay, highlighting the connectivity between different Arctic systems and horizontal components of basin‐scale nutrient transport. Baffin Bay bottom water properties are derived from export production in northern Baffin Bay, which is largely fueled by Pacific‐derived nutrients. In situ remineralization at depth gives rise to benthic denitrification, evidenced by a pronounced accumulation of nitrous oxide with a distinctively high site preference (<44‰) in the deep basin. Nutrients supplied to Baffin Bay are hence stripped from surface waters and trapped at depth over long timescales, where sedimentary denitrification further adds to the N removal capacity of the Arctic Ocean.
A Numerical Study on the 3‐D Approach of the Equatorial Plasma Bubble Seeded by the Prereversal Vertical Drift
Authors: Sousasantos J. , Kherani E. A. , Sobral J. H. A. , Abdu M. A. , Moraes A. O. , Oliveira C. B. A. 
Published: May 2019

AbstractNumerical studies concerning equatorial plasma bubble (EPB) seeding source mechanisms have been performed for the last decades. Density perturbations, gravity waves, shear instabilities among others were used in the literature. In all the cases the prereversal vertical drift has a central role, being a necessary condition in addition to all these seeding mechanisms. Notwithstanding, since the prereversal vertical drift presents an asymmetric distribution, this longitudinal variation was hypothesized to act as a seeding source mechanism. This mechanism is capable of providing both contributions: elevate the ionosphere and seed the collisional interchange instability. Two‐dimensional investigation was already done, showing the validity of this hypothesis in a bidimensional scenario. Nonetheless, the inclusion of the parallel dynamics could alter the outcome of such analysis, once the component of the conductivity along the geomagnetic field direction causes a load effect reducing the growth rate and shifting its altitude of maximization, thus a 3‐D model was developed, named MATPLAB_3D (Mathematical Plasma Bubble Model 3D), and the hypothesis was tested. A progressive approach was performed starting with an oversimplified configuration and concluding with a more realistic profile of prereversal vertical drift obtained using the SAMI2 model. The numerical simulations revealed the existence of a quasi‐gaussian seeding source. Also, in case of a prereversal vertical drift varying within 20–60 m/s, the seeded instability evolves into an EPB structure with a longitudinal extension of ~2° within ~22 min. This EPB maps to low latitude regions and presents secondary structures in its west side. This result further suggests that even though a decrease in the EPB growth due to the inclusion of the parallel conductivity occurred, the hypothesis remains valid.
Control of Convection in High‐Resolution Simulations of Tropical Cyclogenesis
Authors: Raymond D. J. , Kilroy G. 
Published: May 2019

AbstractThree idealized high‐resolution simulations of tropical storm formation from a weak vortex are analyzed. The three simulations include a case using warm rain microphysics, a similar case in which surface friction is omitted, and a case in which ice microphysics is used. The goal is to understand the mechanisms controlling the intensity and distribution of convection in the formation process in each of these cases. Simulations of convection in weak temperature gradient convective models show that a combination of low to middle tropospheric moist convective instability, the saturation fraction or column relative humidity, and the surface moist entropy flux explain a high percentage of the variance in precipitation and lower tropospheric vertical mass flux. Tropical cyclones differ from other convective environments in that intense frictional convergence occurs in the boundary layer. Adding a measure of convective inhibition to account for this process enables the lower tropospheric mass flux to be predicted even in the core regions of the simulated tropical cyclones. These results are pertinent to the development of more accurate convective parameterizations for large‐scale models.
The Role of MJO Propagation, Lifetime, and Intensity on Modulating the Temporal Evolution of the MJO Extratropical Response
Authors: Zheng C. , Chang E. K. M. 
Published: May 2019

AbstractThe Madden‐Julian Oscillation (MJO) is the dominant mode of tropical intraseasonal variability. Many studies have found that the MJO has significant impacts on extratropical weather. Since the MJO can act as a tropical heat source that excites Rossby waves, midlatitude weather is modulated by the MJO due to the Rossby waves that propagate into the midlatitude and modulate the midlatitude circulation. Heat sources of individual MJO events are different since each event has different eastward propagation speed, lifetime, intensity, and structure. The background flow is also different for each event. These result in different Rossby waves and different extratropical response for each MJO event. In this study, the role of MJO propagation speed, lifetime, and intensity on modulating the structure and temporal evolution of the MJO extratropical response is systematically explored by using an idealized general circulation model. By adding the MJO‐associated heating into the general circulation model as an external forcing, the extratropical response in the Reanalysis is captured reasonably by the model. However, large ensemble model simulations show that the response in the Reanalysis is not robust. Experiments with MJO events of different propagation speed, lifetime, and intensity show that to excite a strong extratropical response, the MJO has to propagate through specific phases (Phases 1–3 and 5–7). The intensity, timing, and duration of the extratropical response strongly depend on when the MJO is initiated and when the MJO decays. The extratropical impacts of slow‐ and fast‐propagating MJO also have significant differences, especially on intensity and duration.
Effects of LiDAR DEM Smoothing and Conditioning Techniques on a Topography‐Based Wetland Identification Model
Authors: O'Neil Gina L. , Saby Linnea , Band Lawrence E. , Goodall Jonathan L. 
Published: May 2019

AbstractAccurate and widely available wetland inventories are needed for wetland conservation and environmental planning. We propose an open source, automated wetland identification model that relies primarily on light detection and ranging (LiDAR) digital elevation models (DEMs). LiDAR DEMs are increasingly available and provide the resolution needed to map detailed topographic metrics and areas of likely soil saturation, but the choice of smoothing and conditioning techniques can significantly impact the accuracy of hydrologic parameter extraction. So far, the effect of these preprocessing steps on wetland delineation has not been thoroughly analyzed. We test the response of a Random Forest wetland classifier, using topographic wetness index, curvature, and cartographic depth‐to‐water index as input variables, to combinations of smoothing techniques (none, mean, median, Gaussian, and Perona‐Malik) and conditioning techniques (Fill, Impact Reduction Approach, and A* least‐cost path analysis) for four sites in Virginia, USA. The Random Forest model was configured to account for imbalanced data sets, and manually surveyed wetlands were used for verification. Applying Perona‐Malik smoothing and A* conditioning yielded the highest accuracy across all sites and considerably reduced model runtime. We found that models could be further improved by individualizing the smoothing method and scale to each input variable. Using only topographic information, the wetland identification model could accurately detect wetlands in all sites (81‐91% recall). Model overprediction varied across sites, represented by precision scores ranging from 22 to 69%. In its current form, the wetland model shows strong potential to support wetland field surveying by identifying likely wetland areas.
Structural basis for functional interactions in dimers of SLC26 transporters
Authors: Chang Yung-Ning , Jaumann Eva A. , Reichel Katrin , Hartmann Julia , Oliver Dominik , Hummer Gerhard , Joseph Benesh , Geertsma Eric R. 
Published: May 2019

AbstractThe SLC26 family of transporters maintains anion equilibria in all kingdoms of life. The family shares a 7 + 7 transmembrane segments inverted repeat architecture with the SLC4 and SLC23 families, but holds a regulatory STAS domain in addition. While the only experimental SLC26 structure is monomeric, SLC26 proteins form structural and functional dimers in the lipid membrane. Here we resolve the structure of an SLC26 dimer embedded in a lipid membrane and characterize its functional relevance by combining PELDOR/DEER distance measurements and biochemical studies with MD simulations and spin-label ensemble refinement. Our structural model reveals a unique interface different from the SLC4 and SLC23 families. The functionally relevant STAS domain is no prerequisite for dimerization. Characterization of heterodimers indicates that protomers in the dimer functionally interact. The combined structural and functional data define the framework for a mechanistic understanding of functional cooperativity in SLC26 dimers.
TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
Authors: Arhatte Malika , Gunaratne Gihan S. , El Boustany Charbel , Kuo Ivana Y. , Moro Céline , Duprat Fabrice , Plaisant Magali , Duval Hélène , Li Dahui , Picard Nicolas , Couvreux Anais , Duranton Christophe , Rubera Isabelle , Pagnotta Sophie , Lacas-Gervais Sandra , Ehrlich Barbara E. , Marchant Jonathan S. , Savage Aaron M. , van Eeden Fredericus J. M. , Wilkinson Robert N. , Demolombe Sophie , Honoré Eric , Patel Amanda 
Published: May 2019

AbstractMutations in the polycystins cause autosomal dominant polycystic kidney disease (ADPKD). Here we show that transmembrane protein 33 (TMEM33) interacts with the ion channel polycystin-2 (PC2) at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physiological calcium range in ER liposomes fused to planar bilayers. Consequently, TMEM33 reduces intracellular calcium content in a PC2-dependent manner, impairs lysosomal calcium refilling, causes cathepsins translocation, inhibition of autophagic flux upon ER stress, as well as sensitization to apoptosis. Invalidation of TMEM33 in the mouse exerts a potent protection against renal ER stress. By contrast, TMEM33 does not influence pkd2-dependent renal cystogenesis in the zebrafish. Together, our results identify a key role for TMEM33 in the regulation of intracellular calcium homeostasis of renal proximal convoluted tubule cells and establish a causal link between TMEM33 and acute kidney injury.
Decoding individual differences in STEM learning from functional MRI data
Authors: Cetron Joshua S. , Connolly Andrew C. , Diamond Solomon G. , May Vicki V. , Haxby James V. , Kraemer David J. M. 
Published: May 2019

AbstractTraditional tests of concept knowledge generate scores to assess how well a learner understands a concept. Here, we investigated whether patterns of brain activity collected during a concept knowledge task could be used to compute a neural ‘score’ to complement traditional scores of an individual’s conceptual understanding. Using a novel data-driven multivariate neuroimaging approach—informational network analysis—we successfully derived a neural score from patterns of activity across the brain that predicted individual differences in multiple concept knowledge tasks in the physics and engineering domain. These tasks include an fMRI paradigm, as well as two other previously validated concept inventories. The informational network score outperformed alternative neural scores computed using data-driven neuroimaging methods, including multivariate representational similarity analysis. This technique could be applied to quantify concept knowledge in a wide range of domains, including classroom-based education research, machine learning, and other areas of cognitive science.
Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans
Authors: Ashton P. M. , Thanh L. T. , Trieu P. H. , Van Anh D. , Trinh N. M. , Beardsley J. , Kibengo F. , Chierakul W. , Dance D. A. B. , Rattanavong S. , Davong V. , Hung L. Q. , Chau N. V. V. , Tung N. L. N. , Chan A. K. , Thwaites G. E. , Lalloo D. G. , Anscombe C. , Nhat L. T. H. , Perfect J. , Dougan G. , Baker S. , Harris S. , Day J. N. 
Published: May 2019

AbstractCryptococcus neoformans (C. neoformans var. grubii) is an environmentally acquired pathogen causing 181,000 HIV-associated deaths each year. We sequenced 699 isolates, primarily C. neoformans from HIV-infected patients, from 5 countries in Asia and Africa. The phylogeny of C. neoformans reveals a recent exponential population expansion, consistent with the increase in the number of susceptible hosts. In our study population, this expansion has been driven by three sub-clades of the C. neoformans VNIa lineage; VNIa-4, VNIa-5 and VNIa-93. These three sub-clades account for 91% of clinical isolates sequenced in our study. Combining the genome data with clinical information, we find that the VNIa-93 sub-clade, the most common sub-clade in Uganda and Malawi, was associated with better outcomes than VNIa-4 and VNIa-5, which predominate in Southeast Asia. This study lays the foundation for further work investigating the dominance of VNIa-4, VNIa-5 and VNIa-93 and the association between lineage and clinical phenotype.