bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beta-Cell Function Improved in Insulin Deficient Type 2 Diabetics and Insulin Sensitivity Improved in Insulin-Resistant Type 2 Diabetics during Long-Term Insulin Pump Therapy
Authors: CHOI SOO BONG , HONG EUN SHIL , NOH YUN HEE 
Published: June 2018

We wanted to investigate the changes in beta cell function and insulin sensitivity during long-term CSII therapy in patients with type 2 diabetes (T2D) up to for 3 years. We discontinued oral antidiabetic drugs and applied CSII therapy to T2D patients (number, 110 with 64% of male; age, 59.9 ± 9.1 years; duration, 12.0 ± 9.2 years; HbA1c 8.9 ± 2.0%; BMI 23.5 ± 2.5 kg/m2). Blood samplings were performed yearly for 3 years at overnight fasting and 120 minutes after ingestion of a standard mixed meal (500 kcal). Serum C-peptide, glucose, and HbA1c were measured, and Matsuda Index (MI) were calculated. The patients were grouped into high MI (insulin sensitive group) and low MI (insulin resistant group) groups by the mean value of baseline MI. Mean HbA1c decreased significantly from 8.9% to 6.5% and there was no difference in glycemic control between the two groups. In insulin sensitive group, mean serum C-peptide increased significantly during CSII therapy. In contrast, mean serum C-peptide did not change but mean MI increased significantly in insulin resistant group (Fig. 1).
In conclusion, by the physiological delivery of insulin using insulin pumps, the two main pathophysiologies of T2D, either insulin deficiency or insulin resistance, seemed to be corrected, respectively.

Disclosure
S. Choi: Stock/Shareholder; Self; SOOIL Developments Co., Ltd.. E. Hong: None. Y. Noh: None.
Pooled Analysis of Clinical Trials Investigating the Pharmacokinetics (PK) of Ultra-rapid Insulin BioChaperone Lispro (BCLIS) vs. Lispro (LIS) in Subjects with Type 1 (T1D) and Type 2 (T2D) Diabetes
Authors: HEISE TIM , RANSON AYMERIC , GAUDIER MARTIN , SOULA OLIVIER , ALLUIS BERTRAND , ZIJLSTRA ERIC , GLEZER STANISLAV , MEIFFREN GRÉGORY 
Published: June 2018

BCLIS is an ultra-rapid insulin lispro formulation designed to accelerate the time-action profile vs. conventional short-acting insulin analogs. PK characteristics of single doses of BCLIS and LIS were characterized in four randomized, double-blind, crossover studies in altogether 112 T1D and 51 T2D subjects who received BCLIS and LIS (0.2 U/kg in studies 1 and 2, individualized doses in studies 3 and 4) subcutaneously by syringe. Insulin absorption was consistently faster with BCLIS than with LIS as indicated by reaching early half-maximum insulin levels (early t50%max) 8.4 (95% confidence interval [-9.6;-7.2]) and time to maximum levels (tmax) 10.0 [-14.3;-5.8] min earlier (p&lt;0.0001 for both comparisons). Early insulin exposure was significantly greater for BCLIS for up to 2 hours after administration (Figure). BCLIS also showed faster offset of exposure, with a 22.3 [-28.8;-15.7] min earlier time to late half-maximum insulin levels (late t50%max) (p&lt;0.0001) and a 24% lower late exposure (AUC2-6h; Figure). Total exposure (AUC0-6h) was similar for both formulations in all studies (treatment ratio in pooled analysis 0.99 [0.95;1.03], p=NS).
In conclusion, BCLIS consistently shows faster onset and offset of exposure than conventional LIS in both T1D and T2D.

Disclosure
T. Heise: Research Support; Self; ADOCIA, Boehringer Ingelheim GmbH, Dance Biopharm, Eli Lilly and Company, Janssen Research & Development, MedImmune, Merck Sharp & Dohme Corp., Mylan, Nordic Bioscience, Novo Nordisk A/S, Poxel SA, Roche Diagnostics Corporation, Saniona, Sanofi, Senseonics, Zealand Pharma A/S. Advisory Panel; Self; Novo Nordisk A/S, Mylan. Speaker's Bureau; Self; Dexcom, Inc., Eli Lilly and Company, Novo Nordisk A/S, Sanofi. A. Ranson: Employee; Self; ADOCIA. Stock/Shareholder; Self; ADOCIA. M. Gaudier: Employee; Self; ADOCIA. Stock/Shareholder; Self; ADOCIA. O. Soula: Board Member; Self; ADOCIA. Stock/Shareholder; Self; ADOCIA. Employee; Spouse/Partner; ADOCIA. B. Alluis: None. E. Zijlstra: Speaker's Bureau; Self; Novo Nordisk A/S. Other Relationship; Self; Novo Nordisk A/S. S. Glezer: Stock/Shareholder; Self; Sanofi. Stock/Shareholder; Spouse/Partner; Sanofi. Employee; Self; ADOCIA, Novo Nordisk Inc.. Employee; Spouse/Partner; Pfizer Inc., Teva Pharmaceutical Industries Ltd.. Stock/Shareholder; Spouse/Partner; Teva Pharmaceutical Industries Ltd. G. Meiffren: Employee; Self; ADOCIA. Stock/Shareholder; Self; ADOCIA.
Global Diabetes Prevention Interventions: A Systematic Review and Network Meta-analysis of the Real-World Impact on Incidence, Weight, and Glucose
Authors: Galaviz Karla Ivette , Weber Mary Beth , Straus Audrey , Haw Jeehea Sonya , Narayan K.M. Venkat , Ali Mohammed Kumail 
Published: June 2018

OBJECTIVEUnderstanding the real-world impacts of lifestyle modification (LSM) for diabetes prevention is imperative to inform resource allocation. The purpose of this study was to synthetize global evidence on the impact of LSM strategies on diabetes incidence and risk factors in one parsimonious model.RESEARCH DESIGN AND METHODSPubMed, Embase, Cochrane Library, and ClinicalTrials.gov were searched for studies published between January 1990 and April 2015. Effectiveness/translation studies of any design testing LSM strategies, targeting high-risk populations (with prediabetes or diabetes risk factors), and reporting diabetes incidence, weight, or glucose outcomes were included. We extracted number of diabetes cases/incidence rates and mean changes in weight (kg), fasting blood glucose (FBG, mmol/L), 2-h postload glucose (mmol/L), and hemoglobin A1c (%). Pairwise random-effects and frequentist random-effects network meta-analyses were used to obtain pooled effects.RESULTSSixty-three studies were pooled in the meta-analysis (n = 17,272, mean age 49.7 years, 28.8% male, 60.8% white/European). In analyses restricted to controlled studies (n = 7), diabetes cumulative incidence was 9% among intervention participants and 12% among control participants (absolute risk reduction 3%; relative risk 0.71 [95% CI 0.58, 0.88]). In analyses combining controlled and uncontrolled studies (n = 14), participants receiving group education by health care professionals had 33% lower diabetes odds than control participants (odds ratio 0.67 [0.49, 0.92]). Intervention participants lost 1.5 kg more weight [−2.2, −0.8] and achieved a 0.09 mmol/L greater FBG decrease [−0.15, −0.03] than control participants. Every additional kilogram lost by participants was associated with 43% lower diabetes odds (β = 0.57 [0.41, 0.78]).CONCLUSIONSReal-world LSM strategies can reduce diabetes risk, even with small weight reductions.
Pelatihan Pengembangan Instrumen Tes Mata Pelajaran Matematika SMP
Authors: Prabowo Anggit , Kusdinar Uus , Rahmawati Uki 
Published: June 2018

Tujuan pengabdian kepada masyarakat ini adalah memberikan pelatihan kepada guru matematika SMP untuk mengembangkan instrumen tes matematika SMP. Peserta pelatihan ini terdiri atas 12 guru dari 4 sekolah yaitu SMP Muhammadiyah 1 Godean, SMP Muhammadiyah 1 Gamping, SMP Muhammadiyah 1 Minggir, dan SMP Muhammadiyah 2 Depok, Kabupaten Sleman, Daerah Istimewa Yogyakarta. Kegiatan ini dilaksanakan di SMP Muhammadiyah 1 Godean. Metode pelaksanaan kegiatan pengabdian adalah melalui ceramah, diskusi, dan proyek. Pada kegiatan ceramah pemateri meyampaikan materi tentang teknik penambangan instrumen penilaian sesuai dengan prosedur yang baku dilanjutkan dengan diskusi. Setelah diskusi, peserta pelatihan megerjakan tugas proyek berupa menyusun instrument tes mata pelajaran matematika SMP, menganalisis secara kualitatif, mengujicobakannya, dan menganalisis berdasar data empirik. Melalui pelatihan ini peserta memeroleh keterampilan dalam mengembangkan instrument penilaian tes matematika SMP. Kegiatan ini telah menghasilkan perangkat instrument tes pilihan ganda untuk mata pelajaran matematika SMP untuk materi perbandingan, bangun datar, dan hubungan antar sudut yang terstandar.
Recognition and Reinforcement of Customary Law Community Association and their Rights over Land and Forest in West Nusa Tenggara Province
Authors: Arba Sh. M. Hum 
Published: June 2018

Abstract
This study aims to analyze recognition and reinforcement of customary law community association and their rights over land and forest in West Nusa Tenggara Province because in this region there are still numerous customary law community associations and their jurisdictions that are always owned, controlled, and done for generations. This study is categorized as a normative study that refers to applicable norms and legal concepts (Indonesian positive law) and reality based on the results of the study. The approaches implemented in the study are legislation approach, conceptual approach, and historical approach. This study was conducted by listing the norms of positive law and then confronting the reality which occurs in the society. It can be concluded that the recognition and reinforcement of the right of customary law community over land and forests in the Constitution and legislation is clear and decisive, however the implementation of recognition and reinforcement of customary law community association and their rights in West Nusa Tenggara Province has not been implemented by the government.
Corruption and FDI Inflows: Evidence from India and China
Authors: Hasan Munir , Rahman Mohd Nayyer , Iqbal Badar Alam 
Published: June 2018

Abstract
Foreign Direct Investment (FDI) is considered to be influenced not only by quantitative factors but also by qualitative factors. However, the present literature related to FDI focus more on quantitative factors rather than qualitative factors. One reason is that FDI is itself based on a quantitative benchmark (10% or more investment in equity). The qualitative factors that are related to FDI are governance, democracy, human development index etc. In the present study an endeavor is made to understand that how corruption influence FDI decision. FDI is taken in terms of percentage of GDP and Corruption is represented by Corruption Perception Index. The sample period of the study is from 1995 to 2014.
Semantic representation of similes (based on the Ukrainian, English and Polish languages).
Authors: Oleniak Mariana 
Published: June 2018

Abstract
Since simile in this paper is understood as a figure of speech in which two essentially unlike things are compared and not only as a construction corresponding to the formula X is like Y, the borderline between the semasiological (from form to content) and onomasiological (from content to form) approaches in respect to the analysis of simile is considered to be crucial. The article is devoted to the analysis of the existing formulas for simile that enumerate the elements in the surface structures of most similes and to the elaboration of a formula that would reflect the essence of the relationship of simile elements regardless of their formal expression. Taking into account existing linguistic studies of similes as well as the author’s own understanding of the problem, simile components are described which also have a symbolic reflection in the aforementioned universal formula for similes. Employing the method of conceptual analysis as well as the methods of description and interpretation, modelling and coding, the author devises a new formula for simile, representing all four of its constituents (a tenor, a vehicle, a comparison marker and a commonly shared salient feature). The devised formula is further subjected to analysis for the possibility of being applied to all formal types of simile. The presented formula of a universal character is essential to identify and analyse different types of similes without limiting research to the formations of a certain model. The formula is labelled universal because it characterizes similes regardless of their forms and languages in which they are used.
Acquisition of meaning in bilingual children: Interference, translation and errors
Authors: Klapicová Edita Hornáčková 
Published: June 2018

Abstract
Even though the process of the acquisition of phonology and syntax in bilingual children resembles that of monolinguals, vocabulary acquisition in bilingual children heavily depends on the input in each language. Bialystok (2004, p. 66) holds that “it may be that the acquisition of syntax and phonology is adequately triggered by exposure to the language, but vocabulary needs to be learned”. Children appear to have the capacity for acquiring more than the basic volume of vocabulary necessary for one language system. The aim of the present paper is to examine the following aspects: the processes of the acquisition of meaning; the manifestation of interference, transfer and borrowing; the task of finding translation equivalents; errors in vocabulary usage in bilingual children.
SOLUTIONS TO PROMOTE LINKAGES BETWEEN ACADEMY AND INDUSTRIES FROM INNOVATION SYSTEM APPROACH
Authors: Phạm Hồng Trang , Pham Hong Nhung 
Published: June 2018

The linkage between research areas and industries has brought many benefits to the socio-economic development of a country. In Vietnam, although the mechanism of autonomy in science and technology (S &T) has been established, this linkage is not strong enough. There are many objective and subjective reasons that hinder the formation and development of linkages between research areas and industries. Based on the survey of 4 universities and 4 institutes in the North of Vietnam, the article analyzes the negative factors which affect to the linkage, thus suggesting some solutions for that.
Accordingly, industries play a central role, as investors as well as consumers of S & T products; S & T activities of the universities, institutes apart from the objective of strengthening their self-capacity will mainly serve the needs of industries; The Government plays a supporting role, ensuring the linkage by legal system and also involved in the linkage through public-private partnership process.
Patient-Reported Outcome Measures Used for Neck Disorders: An Overview of Systematic Reviews
Authors: Bobos Pavlos , MacDermid Joy C. , Walton David M. , Gross Anita , Santaguida P. Lina 
Published: June 2018

Background The evaluation of patient-reported outcome measures for the neck from multiple systematic reviews will provide a broader view of, and may identify potential conflicting or consistent results for, their psychometric properties. Objectives The purpose of this study was to conduct an overview of systematic reviews and synthesize evidence to establish the current state of knowledge on psychometric properties of patient-reported outcome measures for patients with neck disorders. Methods In this overview of systematic reviews, an electronic search of 6 databases (MEDLINE, Embase, CINAHL, ILC, the Cochrane Central Register of Controlled Trials, and LILACS) was conducted to identify reviews that addressed at least one measurement property of outcome measures for people with neck pain. Only systematic reviews with patient-reported outcome measures were included in the analysis. Risk of bias was assessed with A MeaSurement Tool to Assess systematic Reviews (AMSTAR). Data on measurement properties were extracted from each systematic review. Results From 13 systematic reviews, 8 patient-reported outcome measures were evaluated in 2 or more reviews. Risk-of-bias scores ranged from moderate (5–7) to high (4 and lower). Findings on internal consistency, test-retest reliability, construct validity, responsiveness to change, and content and structural validity were synthesized for the Neck Disability Index (NDI) in 11 systematic reviews; the Northwick Park Neck Pain Questionnaire and Neck Pain and Disability scale (NPDS) in 6 systematic reviews; the Copenhagen Neck Functional Disability Scale in 5 systematic reviews; the Neck Bournemouth Questionnaire in 4 systematic reviews; the Core Neck Pain Questionnaire and Patient-Specific Functional Scale in 3 systematic reviews, and the Whiplash Disability Questionnaire in 2 systematic reviews. Conclusion High-quality evidence was found of good to excellent internal consistency and moderate to excellent test-retest reliability for the NDI. Moderate-quality evidence was found of good to excellent internal consistency and good test-retest reliability for the Northwick Park Neck Pain Questionnaire. High-quality evidence was found of excellent test-retest reliability and good to strong construct validity with pain scales for the Copenhagen Neck Functional Disability Scale. Moderate-quality evidence was found of unclear to excellent internal consistency and moderate to strong concurrent associations with the NDI and global assessment of change for the Neck Pain and Disability scale. Moderate-quality evidence was found of excellent internal consistency for the Whiplash Disability Questionnaire and of high test-retest reliability for the Patient-Specific Functional Scale. J Orthop Sports Phys Ther 2018;48(10):775–788. Epub 22 Jun 2018. doi:10.2519/jospt.2018.8131
How Do Novice Runners With Different Body Mass Indexes Begin a Self-chosen Running Regime?
Authors: Bertelsen Michael Lejbach , Hansen Mette , Rasmussen Sten , Nielsen Rasmus Oestergaard 
Published: June 2018

Background Overweight and obese novice runners are subjected to a higher load per stride than their normal-weight peers. Do they reduce their running dose accordingly when beginning a self-chosen running regime? Objectives To describe and compare the preferred running dose in normal-weight, overweight, and obese novice runners when they commence a self-chosen running regime. Methods In this exploratory, 7-day prospective cohort study, 914 novice runners were categorized into 1 of 3 exposure groups, based on their body mass index (BMI): (1) normal weight (BMI less than 25 kg/m2, n = 405; reference group), (2) overweight (BMI of 25 to less than 30 kg/m2, n = 341), and (3) obese (BMI of 30 kg/m2 or greater, n = 168). All runners were equipped with a global-positioning-system running watch, which provided information about distance, duration, speed, and date of each running session during the first week of a self-chosen running regime. Results During the first session, overweight runners (difference, −0.5 km/h; 95% confidence interval [CI]: −0.8, −0.2 km/h; P<.05) and obese runners (−1.7 km/h; 95% CI: −2.0, −1.4 km/h; P<.05) ran slower than normal-weight runners. Obese runners also ran a shorter distance compared to normal-weight runners (−0.4 km; 95% CI: −0.7, −0.2 km; P<.05). During the first week, overweight runners (−0.5 km/h; 95% CI: −0.7, −0.2 km/h; P<.05) and obese runners (−1.7 km/h; 95% CI: −2.0, −1.4 km/h; P<.05) ran slower than normal-weight runners, while running distance and duration were similar. Conclusion Overweight and obese runners selected a similar training dose to that of normal-weight runners when starting a self-chosen running regime. This may partly explain the higher running-injury risk among overweight and obese runners compared with normal-weight runners observed by other studies. J Orthop Sports Phys Ther 2018;48(11):873–877. Epub 22 Jun 2018. doi:10.2519/jospt.2018.8169
Anlatının Söylemi: Yöntem Hakkında Bir Deneme
Authors: PARIN Kamil 
Published: June 2018

Gérard Genette tarafından
kaleme alınan Anlatının Söylemi, 2011
yılında Ferit Burak Aydar tarafından çevirisi yapılır ve Boğaziçi Üniversitesi
Yayınevi tarafından basılır. Eser; Ön söz ve Giriş kısmından sonra Düzen, Süre,
Sıklık, Kip ve Ses olmak üzere beş bölümden oluşur. Son söz, Kaynakça ve Dizin
ile sona erer. Eserin alt başlıkları şu şekildedir: 1. Düzen; Anlatı Zamanı? Anakroniler,
Erim-Kapsam, Analepsisler, Prolepsisler, Anakroniye Doğru. 2. Süre;
Anisokroniler, Özet, Ara, Eksilti, Sahne. 3. Sıklık; Tekilci/Yinelemeli,
Belirlenim-Saptama-Kaplam, İçsel ve Dışsal Artzamanlılık, Münavebe-Geçişler,
Zamanla Oynanan Oyun. 4. Kip; Anlatı Kipleri, Mesafe, Olay Anlatıları, Sözcük
Anlatıları, Perspektif, Odaklanmalar, Değiştirmeler, Çok-Kiplilik. 5. Ses;
Anlatılama Edimi, Anlatılama Zamanı, Anlatı Düzeyleri, Üst Öyküsel Anlatı,
Metalepsis, Jean Santeuil’den Kayıp Zaman’a: Sözde Öyküselin Zafer, Şahıs,
Kahraman/Anlatıcı, Anlatıcının İşlevleri, Anlatılan.Eserin beş bölümden oluştuğunu ifade etmiştik. Şimdi
bölümlerde neleri ele almış bunlara değineceğiz. Birinci bölüm, olayların nasıl
sıralandığıyla ilgili düzen bölümüdür. Genette anlatıdaki olayların kronolojik
olmayan düzenini “anakroni” (hikâye ile anlatının iki düzenlenişi arasındaki
farklı uyumsuzluktur) terimiyle ifade eder. Genette “öngörü” ve “geriye dönüş”
terimlerini kullanmak yerine anakroniyi ikiye ayırır: Analepsis ve Prolepsis.
Analepsis: Anlatıcı önceden olmuş bir olayı ya da olayları anlatır. Prolepsis: Sonra
yer alacak bir olayı şimdiden anlatılamak ya da çağrıştırmaktan ibaret olan
anlatı manevrası. Genette, eksilti ya da geri dönüşsüz ileri atlamayı anakroni olarak
kabul etmez, yalnızca anlatının hızlandırılmasıdır der. Ayrıca halk anlatısının,
en azından en önemli eklemlenişlerinde kronolojik sıraya alışkanlıkla uyum
gösterdiğini, oysa Batılı edebi geleneğin tam tersine anakroninin tipik bir
etkisiyle başladığını düşünür. Anakronileri, geriye dönüş ve öngörü üzerinden
analepsis ve prolepsis olarak adlandırdıktan sonra herhangi bir benzerlik
(mekânsal, zamansal ya da başka türlü) tarafından yönetilen anakronik öbeklere
de silepsis (beraber olma olgusu) adını verir.
An Analytical Approach for Decision-Making
Authors: Aggarwal Sakshi , Sagar Shrddha 
Published: June 2018

In this complex world, coping with daily problems is quite tedious. The more advancement in technology means more difficulties in decision-making process. Hence some analytical tools are needed to deal with improvement in decisions being made. A classic AHP model enables us to make efficient decision by reducing the complex issues. It takes multiple parameters into consideration. One of the area where decision-making is quite a tough job is Politics. Selection of the electoral party in any elections, be it Lok Sabha elections or Rajya Sabha elections, has been a matter of discussion for the voters as well as the media. The decisions are reflected when uncertainties are added in the opinions of the domain experts due to multiple parameters.Â In this paper we have proposed a model for rectifying the uncertainties using multi criteria decision analysis and analytic hierarchy process (AHP).
Model of long-length part flattening by mobile local bend
Authors: Королев Альберт , Korolev Albert , Решетников Михаил , Reshetnikov Mihail , Савран Сергей , Savran Sergey 
Published: June 2018

In the paper there is described a method of flattening and stabilization of geometrical parameters of long-length parts. The method is based on the formation of a uniform area displacement of an elasto-plastic deformation formed by a bending moment at continuous rotation of a part which results in the occurrence of multi-cycle loading. Because of the action of controlled multi-cycle loading takes place an accumulation and further relaxation of inner stresses.
The process of flattening and stabilization of geometrical parameters is described by a simulator showing a tie between geometrical, physic-mechanical and technological parameters. At the heart of a simulator is an energy approach to the description of an elasto-plastic deformation of a part at multi-cycle loading.