bluuebunny/crossref_metadata_2025_split huggingface dataset:
From dreadful shame to manageable incident: How post-mortem cleaning workers’ narratives change the feeling rules about “lonely deaths” in Japan
Authors: Toyota Mika 
Published: November 2024

Abstract
Since the 1990s, Japan has experienced the rise of a phenomenon known as “lonely death” (kodokushi 孤独死): people who die alone and whose death goes unnoticed for a certain period of time. This has triggered public anxiety and moral panic because lonely death is often perceived as a form of “bad death” and a sign of the breakdown of family ties and neighborly relations. In the 2020s, this “feeling rule,” which associates lonely death with shame and fear, has quietly begun to be challenged by a group of post-mortem cleaning workers. By sharing their work experience and feelings through blogs, artworks, and books, the workers’ accounts of how they deal with the remnants of the deceased have turned the public perception of lonely death from an abstract, totalizing, fearful category into an understanding that such incidents have specific causes that can be faced and even prepared for. The cleaners’ emotional labor, especially their mourning for the dead, creates a sense of relatedness to the deceased, a feeling which is conveyed to the public through the cleaners’ narratives. The cleaners thereby change the feeling rules associated with the labor of dealing with the aftermath of a lonely death, turning it from “dirty work” into meaningful social action. This article contributes to an understanding of feeling rules by highlighting how individuals’ efforts, particularly, their reflections on their emotional labor, can change collective feeling rules.
Postdoc Perspectives on Leadership and Matters of Equity and Inclusion in Polar Science
Authors: Goliber Sophie , Coenen Jason , Fair Heather , Szesciorka Angela R. , Schulz Kirstin , Harning David J. , Fernando Benjamin , Ksenofontov Stanislav Saas , Pacini Astrid , Rivera Marisol Juarez , Calmer Radiance , Conroy John A. , Doting Eva Lisa , Bergelin Marie , Dunmire Devon , Sánchez Montes Maria Luisa , Ravelo Alexandra M. , Sledd Anne , Stinchcomb Taylor R. , Tibbett Emily J. , Dryák‐Vallies Mariama C. 
Published: November 2024

AbstractIn 2023, the first Polar Postdoc Leadership Workshop convened to discuss present and future polar science issues and to develop leadership skills. The workshop discussions fostered a collective commitment to inclusive leadership within the polar science community among all participants. Here, we outline challenges encountered by underrepresented groups in polar sciences, while also noting that progress has been made to improve inclusivity in the field. Further, we highlight the inclusive leadership principles identified by workshop participants to bring to the polar community as we transition into leadership roles. Finally, insights and practical knowledge we gained from the workshop are shared, aiming to inform the community of our commitment to inclusive leadership and encourage the polar community to join us in pursuing action toward our shared vision for a more welcoming polar science future.
3‐D Subsurface Geophysical Modeling of the Charity Shoal Structure: A Probable Late Proterozoic‐Early Paleozoic Simple Impact Structure in Eastern Lake Ontario
Authors: Armour Mary H. , Boyce Joseph I. , Suttak Phillip , Hrvoic Doug 
Published: November 2024

AbstractThe Charity Shoal structure is a circular, ∼1.2‐km‐diameter, bedrock‐rimmed shoal in eastern Lake Ontario with a ∼20‐m‐deep central basin. The structure has been proposed as a possible Middle Ordovician impact crater or volcanic intrusion. We conducted marine seismic and magnetic surveys (9‐km2) and 3‐D geophysical modeling to better resolve the Charity Shoal subsurface geology and possible origins. Three models were evaluated: (a) a buried (>450 m) impact structure in Mesoproterozoic basement, (b) a maar‐diatreme, (c) a cylindrical, zoned volcanic plug. Seismic profiles and multi‐beam bathymetry revealed >30 m of Quaternary sediments overlying Middle Ordovician (Trenton Group) carbonate bedrock and complex, 3‐dimensional folding and faulting of the structure rim. Magnetic surveys recorded an annular magnetic high (>600 nT) over the structure rim and a central magnetic low (∼500–600 nT) coincident with a ∼−1.7 mGal Bouguer gravity anomaly. The continuity of Trenton Group strata in seismic profiles rules out a previously proposed Mesozoic maar‐diatreme intruded into Paleozoic strata. The zoned volcanic plug model reproduced the annular magnetic anomaly but was incompatible with Bouguer gravity profiles. The magnetic anomaly was best reproduced by a simple impact structure seated in Mesoproterozoic basement at 450–500 m depth with a rim‐to‐rim diameter of ∼1.2 km and rim height of ∼10–20 m. A 100‐m wide and 50‐m‐deep channel in the Mesoproterozoic basement may record fluvial dissection of the southwestern rim. A buried (>450 m), simple impact crater is most compatible with all available geophysical data at Charity Shoal.
Can Large Strains Be Accommodated by Small Faults: “Brittle Flow of Rocks” Revised
Authors: Zou Xiaoyu , Fialko Yuri 
Published: November 2024

AbstractBrittle deformation in the upper crust is thought to occur primarily via faulting. The fault length‐frequency distribution determines how much deformation is accommodated by numerous small faults versus a few large ones. To evaluate the amount of deformation due to small faults, we analyze the fault length distribution using high‐quality fault maps spanning a wide range of spatial scales from a laboratory sample to an outcrop to a tectonic domain. We find that the cumulative fault length distribution is well approximated by a power law with a negative exponent close to 2. This is in agreement with the earthquake magnitude‐frequency distribution (the Gutenberg‐Richter law with b‐value of 1), at least for faults smaller than the thickness of the seismogenic zone. It follows that faulting is a self‐similar process, and a substantial fraction of tectonic strain can be accommodated by faults that don't cut through the entire seismogenic zone, consistent with inferences of “hidden strain” from natural and laboratory observations. A continued accumulation of tectonic strain may eventually result in a transition from distributed fault networks to localized mature faults.
Observations Over a Century Underscore an Increasing Likelihood of Compound Dry‐Hot Events in China
Authors: Duan Ruixin , Huang Guohe , Wang Feng , Tian Chuyin , Wu Xinying 
Published: November 2024

AbstractThe impacts of extreme events are seldom caused by a single climatic variable but rather arise from the interaction of multiple climate drivers. This study employs observational data sets with high spatiotemporal resolution to analyze the risk of occurrence of compound dry‐hot events in China over the past 120 years (i.e., 1901–2020). Simultaneously, attribution analysis based on distribution functions explores whether and to what extent human activities influence the occurrence of compound events. The results indicate that over the historical 120‐year period, the frequency of compound dry‐hot events in China has gradually increased, with the highest frequency observed in the most recent 40 years (i.e., 1981–2020). The frequency of compound dry‐hot events during this period is approximately four times that of 1901–1940 and about twice that of 1941–1980. The analysis of the relative importance of different factors reveals that temperature changes contribute more (56%) to the occurrence of compound events than precipitation (23%), and also exceed the interaction between them (21%). The substantial increase in compound dry‐hot events is largely attributed to the influence of human activities. Across seven sub‐regions, human activities have led to an increase in the probability of compound events occurring, ranging from 7.9% to 31.6%. The findings of this study indicate that human activities have significant implications for explaining the observed increase in compound hot and dry events over the past 40 years.
Lunar Nearside‐Farside Mare Basalt Asymmetry: The Combined Role of Global Crustal Thickness Variations and South Pole‐Aitken (SPA) Basin‐Induced Lithospheric Thickening
Authors: Head James W. , Wang Xing , Lark Laura H. , Wilson Lionel , Qian Yuqi 
Published: November 2024

AbstractLunar mare basalts represent melting of mantle material, buoyant ascent in dikes, and eruption onto <20% of the surface. Global mare distribution is distinctly asymmetrical, with a paucity on the farside, plausibly interpreted to be related to thicker farside low‐density crust inhibiting buoyant magma rise to the surface. Challenging this hypothesis is the presence of the huge, ancient farside South Pole‐Aitken (SPA) basin, site of the thinnest crust and deepest depression observed on the Moon. We hypothesize that an oblique impact stripped the farside crust within the SPA basin, permitting early mare basalt emplacement as cryptomaria due to thin/absent crust. However, removal of the SPA thermally insulating megaregolith/crust accelerated lithosphere thickening beneath the basin. This deepening rheological barrier inhibited buoyant rise of mantle diapirs below SPA, resulting in early abatement of mare basalt extrusions compared to the nearside, and retention of the deep, underfilled SPA impact basin observed today.
A Critical Core Size for Dynamo Action at the Galilean Satellites
Authors: Trinh K. T. , Bierson C. J. , O’Rourke J. G. 
Published: November 2024

AbstractGanymede is the only known moon with an active dynamo. No mission has discovered intrinsic magnetism at the other Galilean satellites: Io, Europa, and Callisto. A dynamo requires a large magnetic Reynolds number, which in turn demands, for these moons, a large metallic core that is cooling fast enough for convection. Here we quantify these requirements to construct a regime diagram for the Galilean satellites. We compute the internal heat fluxes that would sustain a dynamo over the wide ranges of plausible radii for their metallic cores. Below a critical radius, no plausible heat flux will sustain a dynamo. Europa likely sits on the opposite side of this limit than Ganymede and Io. We predict that future missions may confirm a small (or absent) core, meaning that Europa could not sustain a dynamo even if its interior were cooling as quickly as Ganymede's core.
Seasonal Upwelling Forecasts in the California Current System
Authors: Amaya Dillon J. , Jacox Michael G. , Alexander Michael A. , Bograd Steven J. , Jia Liwei 
Published: November 2024

AbstractCoastal upwelling plays a vital role in the support and maintenance of productive marine ecosystems throughout the California Current System (CCS). Here, we evaluate upwelling forecast skill using ∼30 years of seasonal reforecasts from four global climate models contributing to the North American Mulitmodel Ensemble (NMME). The models skillfully predict upwelling intensity throughout much of the CCS in boreal winter, and in the South‐Central CCS in spring/summer. The models also skillfully predict various aspects of upwelling phenology, including the timing of the spring transition, as well as the total vertical transport integrated over the course of the upwelling season. Climatic sources of forecast skill vary with season, with contributions from the El Niño‐Southern Oscillation in winter‐spring, and the North Pacific Oscillation and the North Pacific Meridional Mode in the winter‐summer. Our results highlight the potential of seasonal climate forecasts to inform management of upwelling‐sensitive marine resources.
Limited Preservation of Strike‐Slip Surface Displacement in the Geomorphic Record
Authors: Reitman Nadine G. , Klinger Yann , Briggs Richard W. , Gold Ryan D. 
Published: November 2024

AbstractOffset geomorphic markers are commonly used to interpret slip history of strike‐slip faults and have played an important role in forming earthquake recurrence models. These data sets are typically analyzed using cumulative probability methods to interpret average amounts of slip in past earthquakes. However, interpretation of the geomorphic record to infer surface slip history is complicated by slip variability, measurement uncertainty, and modification of offset features in the landscape. To investigate how well geomorphic data record surface slip, we use offset measurements from recent strike‐slip surface ruptures (n = 39), faults with geomorphic evidence of multiple strike‐slip earthquakes (n = 29), and synthetic slip distributions with added noise (n10,000) to examine the constraints of the geomorphic record and the underlying assumptions of the cumulative offset probability distribution analysis method. We find that the geomorphic record is unlikely to resolve more than two paleo‐slip distributions, except in specific cases with low slip variability, high slip‐per‐event, and semiarid climate. In cases where site‐specific conditions allow for interpretation of more than two earthquakes, lateral extrapolation along a fault is not straightforward because on‐fault displacement and distributed deformation may be spatially variable in each earthquake. We also find that average slip in modern earthquakes is adequately recovered by probability methods, but the reported prevalence of strike‐slip faults with characteristic slip history is not supported by geomorphic data. We also propose updated methods to interpret slip history and construct uncertainty bounds for paleo‐slip distributions.
Matching patients to clinical trials with large language models
Authors: Jin Qiao , Wang Zifeng , Floudas Charalampos S. , Chen Fangyuan , Gong Changlin , Bracken-Clarke Dara , Xue Elisabetta , Yang Yifan , Sun Jimeng , Lu Zhiyong 
Published: November 2024

AbstractPatient recruitment is challenging for clinical trials. We introduce TrialGPT, an end-to-end framework for zero-shot patient-to-trial matching with large language models. TrialGPT comprises three modules: it first performs large-scale filtering to retrieve candidate trials (TrialGPT-Retrieval); then predicts criterion-level patient eligibility (TrialGPT-Matching); and finally generates trial-level scores (TrialGPT-Ranking). We evaluate TrialGPT on three cohorts of 183 synthetic patients with over 75,000 trial annotations. TrialGPT-Retrieval can recall over 90% of relevant trials using less than 6% of the initial collection. Manual evaluations on 1015 patient-criterion pairs show that TrialGPT-Matching achieves an accuracy of 87.3% with faithful explanations, close to the expert performance. The TrialGPT-Ranking scores are highly correlated with human judgments and outperform the best-competing models by 43.8% in ranking and excluding trials. Furthermore, our user study reveals that TrialGPT can reduce the screening time by 42.6% in patient recruitment. Overall, these results have demonstrated promising opportunities for patient-to-trial matching with TrialGPT.
Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model
Authors: Stockinger Alexander W. , Adelmann Leonie , Fahrenberger Martin , Ruta Christine , Özpolat B. Duygu , Milivojev Nadja , Balavoine Guillaume , Raible Florian 
Published: November 2024

AbstractRegeneration of missing body parts can be observed in diverse animal phyla, but it remains unclear to which extent these capacities rely on shared or divergent principles. Research into this question requires detailed knowledge about the involved molecular and cellular principles in suitable reference models. By combining single-cell RNA sequencing and mosaic transgenesis in the marine annelid Platynereis dumerilii, we map cellular profiles and lineage restrictions during posterior regeneration. Our data reveal cell-type specific injury responses, re-expression of positional identity factors, and the re-emergence of stem cell signatures in multiple cell populations. Epidermis and mesodermal coelomic tissue produce distinct putative posterior stem cells (PSCs) in the emerging blastema. A novel mosaic transgenesis strategy reveals both developmental compartments and lineage restrictions during regenerative growth. Our work supports the notion that posterior regeneration involves dedifferentiation, and reveals molecular and mechanistic parallels between annelid and vertebrate regeneration.
Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease
Authors: Barbehenn Alton , Shi Lei , Shao Junzhe , Hoh Rebecca , Hartig Heather M. , Pae Vivian , Sarvadhavabhatla Sannidhi , Donaire Sophia , Sheikhzadeh Caroline , Milush Jeffrey , Laird Gregory M. , Mathias Mignot , Ritter Kristen , Peluso Michael J. , Martin Jeffrey , Hecht Frederick , Pilcher Christopher , Cohen Stephanie E. , Buchbinder Susan , Havlir Diane , Gandhi Monica , Henrich Timothy J. , Hatano Hiroyu , Wang Jingshen , Deeks Steven G. , Lee Sulggi A. 
Published: November 2024

AbstractDespite antiretroviral therapy (ART), HIV persists in latently-infected cells (the HIV reservoir) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people living with HIV (PLWH) treated during acute infection, we developed a mathematical model to predict reservoir decay from peripheral CD4 + T cells. Nonlinear generalized additive models demonstrated rapid biphasic decay of intact DNA (week 0-5: t1/2 ~ 2.83 weeks; week 5-24: t1/2 ~ 15.4 weeks) that extended out to 1 year. These estimates were ~5-fold faster than prior decay estimates among chronic treated PLWH. Defective DNA had a similar biphasic pattern, but data were more variable. Predicted intact and defective decay rates were faster for PLWH with earlier timing of ART initiation, higher initial CD4 + T cell count, and lower pre-ART viral load. In this study, we advanced our limited understanding of HIV reservoir decay at the time of ART initiation, informing future curative strategies targeting this critical time.
Chromatin compaction during confined cell migration induces and reshapes nuclear condensates
Authors: Zhao Jessica Z. , Xia Jing , Brangwynne Clifford P. 
Published: November 2024

AbstractCell migration through small constrictions during cancer metastasis requires significant deformation of the nucleus, with associated mechanical stress on the nuclear lamina and chromatin. However, how mechanical deformation impacts various subnuclear structures, including protein and nucleic acid-rich biomolecular condensates, is largely unknown. Here, we find that cell migration through confined spaces gives rise to mechanical deformations of the chromatin network, which cause embedded nuclear condensates, including nucleoli and nuclear speckles, to deform and coalesce. Chromatin deformations exhibit differential behavior in the advancing vs. trailing region of the nucleus, with the trailing half being more permissive for de novo condensate formation. We show that this results from increased chromatin heterogeneity, which gives rise to a shift in the binodal phase boundary. Taken together, our findings show how chromatin deformation impacts condensate assembly and properties, which can potentially contribute to cellular mechanosensing.
Mechanistic basis of atypical TERT promoter mutations
Authors: Elliott Kerryn , Singh Vinod Kumar , Bäckerholm Alan , Ögren Linnea , Lindberg Markus , Soczek Katarzyna M. , Hoberg Emily , Luijts Tom , Van den Eynden Jimmy , Falkenberg Maria , Doudna Jennifer , Ståhlberg Anders , Larsson Erik 
Published: November 2024

AbstractNon-coding mutations in the TERT promoter (TERTp), typically at one of two bases −124 and −146 bp upstream of the start codon, are among the most prevalent driver mutations in human cancer. Several additional recurrent TERTp mutations have been reported but their functions and origins remain largely unexplained. Here, we show that atypical TERTp mutations arise secondary to canonical TERTp mutations in a two-step process. Canonical TERTp mutations create de novo binding sites for ETS family transcription factors that induce favourable conditions for DNA damage formation by UV light, thus creating a hotspot effect but only after a first mutational hit. In agreement, atypical TERTp mutations co-occur with canonical driver mutations in large cancer cohorts and arise subclonally specifically on the TERTp driver mutant chromosome homolog of melanoma cells treated with UV light in vitro. Our study gives an in-depth view of TERTp mutations in cancer and provides a mechanistic explanation for atypical TERTp mutations.
A modular platform for bioluminescent RNA tracking
Authors: Halbers Lila P. , Cole Kyle H. , Ng Kevin K. , Fuller Erin B. , Chan Christelle E. T. , Callicoatte Chelsea , Metcalfe Mariajose , Chen Claire C. , Barhoosh Ahfnan A. , Reid-McLaughlin Edison , Kent Alexandra D. , Torrey Zachary R. , Steward Oswald , Lupták Andrej , Prescher Jennifer A. 
Published: November 2024

AbstractA complete understanding of RNA biology requires methods for tracking transcripts in vivo. Common strategies rely on fluorogenic probes that are limited in sensitivity, dynamic range, and depth of interrogation, owing to their need for excitation light and tissue autofluorescence. To overcome these challenges, we report a bioluminescent platform for serial imaging of RNAs. The RNA tags are engineered to recruit light-emitting luciferase fragments (termed RNA lanterns) upon transcription. Robust photon production is observed for RNA targets both in cells and in live animals. Importantly, only a single copy of the tag is necessary for sensitive detection, in sharp contrast to fluorescent platforms requiring multiple repeats. Overall, this work provides a foundational platform for visualizing RNA dynamics from the micro to the macro scale.
Tailoring superstructure units for improved oxygen redox activity in Li-rich layered oxide battery’s positive electrodes
Authors: Liu Hao , Hua Weibo , Kunz Sylvia , Bianchini Matteo , Li Hang , Peng Jiali , Lin Jing , Dolotko Oleksandr , Bergfeldt Thomas , Wang Kai , Kübel Christian , Nagel Peter , Schuppler Stefan , Merz Michael , Ying Bixian , Kleiner Karin , Mangold Stefan , Wong Deniz , Baran Volodymyr , Knapp Michael , Ehrenberg Helmut , Indris Sylvio 
Published: November 2024

AbstractThe high-voltage oxygen redox activity of Li-rich layered oxides enables additional capacity beyond conventional transition metal (TM) redox contributions and drives the development of positive electrode active materials in secondary Li-based batteries. However, Li-rich layered oxides often face voltage decay during battery operation. In particular, although Li-rich positive electrode active materials with a high nickel content demonstrate improved voltage stability, they suffer from poor discharge capacity. Here, via physicochemical and electrochemical measurements, we investigate the correlation between oxygen redox activity and superstructure units in Li-rich layered oxides, specifically the fractions of LiMn6 and Ni4+-stabilized LiNiMn5 within the TM layer. We prove that an excess of LiNiMn5 hinders the extraction/insertion of lithium ions during Li metal coin cell charging/discharging, resulting in incomplete oxygen redox activity at a cell potential of about 3.3 V. We also demonstrate that lithium content adjustment could be a beneficial approach to tailor the superstructure units. Indeed, we report an improved oxygen redox reversibility for an optimized Li-rich layered oxide with fewer LiNiMn5 units.