bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of Renal Fibrosis and Glomerular Injury by Sacubitril/Valsartan, a Combination Angiotensin Receptor Blocker and Neprilysin Inhibitor, in a Salt-Sensitive Hypertensive Model Using Angiotensin 1 Receptor Knockout Mice: The Contribution of Non-Angiotensin Blocking Effects to Renal Protection
Authors: Otsu Rei , Taniyama Yoshiaki , Sanada Fumihiro , Muratsu Jun , Shibata Kana , Fujikawa Tatsuya , Brule Kanako May , Shimizu Hideo , Rakugi Hiromi , Morishita Ryuichi 
Published: December 2018

Introduction:
“Aldosterone breakthrough,” which is observed in patients receiving long term treatment with angiotensin blockade, is strongly associated with the increased risk of a declining glomerular filtration rate through the profibrotic actions of aldosterone. Sacubitril/valsartan is a newly created combination medicine (the angiotensin receptor blocker valsartan and the neprilysin-inhibitor sacubitril). Therefore, sacubitril/valsartan should have additional organ-protective actions besides the angiotensin blockade.

Methods:
In this study, we examined the renal protective effect of sacubitril/valsartan in a salt-sensitive hypertension model using angiotensin II type 1a receptor (AT1aR) knockout mice. An oral administration of 1% NaCl solution with sacubitril/valsartan (30 or 60 mg/kg/day) or valsartan (15 or 30 mg/kg/day) alone beginning 7 days before administration of aldosterone was examined in an aldosterone infusion AT1R knockout mouse model as an aldosterone breakthrough model.

Results / Conclusion:
A significant decrease in Blood Pressure (BP) was observed in the sacubitril/valsartan group compared to the valsartan group under low and high doses. In addition, the pathological analysis of the kidney for glomerular fibrosis by Sirius red staining and for injury by PAS staining demonstrated significant reductions accompanied by a significant reduction in TGF-β in the sacubitril/valsartan group compared to the valsartan group. Overall, sacubitril/valsartan, which has the dual actions of the AT1R blockade and neprilysin inhibition, may have additional clinical values for the treatment of hypertensive patients with aldosterone breakthrough.
Construction and Validation of an Online Subcritical Adsorption-based Device for Assisting CO2 Recycling during a Supercritical Fluid Extraction Process
Authors: Torres R. Abel C. , Santos Diego T. , Meireles M. Angela A. 
Published: December 2018

Background:An efficient process for extracting food ingredients from plant materials should demand the use of a reduced volume of extraction solvent to obtain a final product that is free of solvent and reduces both the processing time and the costs. In some cases, achieving a new efficient process requires the modification, reconfiguration or renewal of elements that are part of a processing unit.Objective:The goal of this work is to describe the development of a modification of a commercial supercritical fluid extraction pilot unit designed to assist CO2recycling based on subcritical adsorption on an adsorbent material. In addition to the construction and validation of the system, a cost survey was performed to estimate the cost of the homemade device developed to allow effective CO2recycling.Methods:The developed device was tested using cotton and Celite®as model adsorption materials and annatto seeds (Bixa orellana L.) as a model plant material. A 0.65 L adsorption column was installed with a set of connections and valves that complemented the unit’s recycle system. The validation procedure consisted of defatting annatto seeds.Results:The proposed online subcritical adsorption-based device was technically validated using cotton as an adsorbent material. The cost survey showed that an estimated total cost of USD 5731.36 would be required to install the developed device in a Supercritical Fluid Extraction (SFE) unit similar to the one coupled here (5 L).Conclusion:The proposed device was demonstrated to be very promising for application in the pseudocontinuous SFE, recirculating the same amount of CO2mass exceeding the S/F values by 14 times, when compared to a process without a CO2recycling system.
Single-Session Low Duration Panretinal Photocoagulation Using Conventional Laser on Central Subfield Macular Thickness in Diabetic Retinopathy
Authors: Kartasasmita Arief S , Yollamanda Prettyla , Ihsan Grimaldi , Virgana Rova 
Published: December 2018

Objective:To compare the change in central subfield macular thickness following single-session and multiple-session laser panretinal photocoagulation in subjects with diabetic retinopathy.Methods:A single-center, randomized controlled trial study was performed on 28 eyes of 16 patients with severe non-proliferative diabetic retinopathy or proliferative diabetic retinopathy. Eyes were randomly assigned for treatment with panretinal photocoagulation performed either in single-session or multiple-session divided into three sessions during two-week period. Central subfield macular thickness was quantified using spectral domain optical coherence tomography and changes at four weeks follow-up were compared to the baseline measurement.Result:Mean baseline central subfield macular thickness of 12 eyes underwent single-session and 16 eyes underwent multiple-session panretinal photocoagulation were 342.91+109.51 micrometers and 354+171.79 micrometers (p> .05), respectively. Mean post laser central subfield macular thickness in the single-session group was 305.83+81.95 micrometers and 389.75+229.51 micrometers in the multiple-session group (p> .05). Mean central subfield macular thickness changes four weeks post laser was 37.08+94.21 micrometers for eyes treated with single-session and -35.75+123.62 micrometers for the multiple-session treated eyes (p= .101).Conclusion:There was no significant difference in change of central subfield macular thickness at four weeks post laser from treatment with single-session and multiple-session panretinal photocoagulation. Single-session panretinal photocoagulation can be used as effective multiple-session panretinal photocoagulation for the treatment of diabetic retinopathy.
Antidiabetic Effect of Aqueous Corrigiola telephiifolia in Streptozotocin- Induced Diabetic Rats
Authors: Hebi Morad , Eddouks Mohamed 
Published: December 2018

Background:
Corrigiola telephiifolia Pourr, is a perennial species, woody distributed
throughout the north of Africa. This plant is used in traditional Mediterranean preparations and has
many traditional uses especially treatment of diabetes.

Aim/Methods:
The current research was carried out to evaluate the antidiabetic effect of Aerial Parts of
Aqueous Extract (APAE) of Corrigiola telephiifolia (C. telephiifolia) on both normal and streptozotocin
(STZ)-induced diabetic rats treated at a dose of 5 mg/kg for fifteen days. Additionally, the histopathological
changes in the liver, morphometric analysis, Oral Glucose Tolerance Test (OGTT) in normal
rats and preliminary phytochemical screening for various components were realized.

Results:
Single oral administration of the APAE of C. telephiifolia (5mg/kg) showed no significant
change in glycaemia of normal and STZ-induced diabetic rats. In contrast, repeated oral administration
of C. telephiifolia reduced blood glucose levels from 4.11 ± 0.10 mmol/L to 3.16 ± 0.16
mmol/L (p<0.01) 15 days after administration in normal rats. Furthermore, blood glucose levels decreased
from 17.84 ± 1.75mmol/L to 1.93 ± 0.33 mmol/L (p<0.0001) in STZ diabetic rats after fifteen
days of treatment. According to the oral glucose tolerance test, C. telephiifolia (5 mg/kg) was
shown to prevent significantly the increase in blood glucose levels in normal treated rats 30 min after
glucose administration when compared to the control group. Also, the liver architecture of diabetic
rats treated by C. telephiifolia was improved when compared with the liver architecture of untreated
diabetic rats. Concerning the preliminary phytochemical screening of C. telephiifolia, several
compounds have been found such as polyphenols, flavonoids, saponins, mucilage and terpenoids.

Conclusion:
The results show that the aqueous extract of C. telephiifolia possesses significant antihyperglycemic
activity.
A Novel Model for Aligning Knowledge Management Activities within the Process of Developing Quality Software
Authors: Sabri Omar 
Published: December 2018

Background:
Currently, the organization's competitive advantage is based on critical decisions
to achieve their objectives by understanding the power of knowledge as a source within the organizations.
However, there is a lack of qualitative models/frameworks for integrating Knowledge Life
Cycle (KLC) within software development life cycle SDLC. Therefore, the goal of this research is to
involve Knowledge Management activities within the SDLC in Information Technology companies to
produce quality software. With the help of knowledge movements within the companies, the quality of
provided software is used to improve organizations performance and products better and faster.

Methods:
This research highlights the importance of Knowledge Management activities during a
typical software development process to provide the software as a final product/target. Moreover, the
paper proposes a model to explain the relationships between knowledge management activities within
the process of software development life cycle to produce quality software using three basic building
blocks: people, organizations, and technologies. The success factors for the blocks are selected
depending on the most recent literature occurrences and on their fitness to the nature of this study.

Results:
The research proposes a novel model for the success factors to evaluate the effects of the
building blocks, and workflows during the software development processes. The selected success
factors for the blocks are (Training, Leadership, Teamwork, Trust, IT Infrastructure, Culture, and
strategies). Also, the research demonstrates the relationships between KM success factors and SDLC
to produce quality software.

Conclusion:
In this research, we proposed a novel model to explain the relationships between
knowledge management activities within the process of software development life cycle to produce
quality software using three basic building blocks: people, organizations, and technologies. We selected
seven success factors for the blocks depending on: 1) their importance and occurrence in a
number of literature by many authors; and 2) their fitness to the nature of this study. The success
factors (Training, Leadership, Teamwork, Trust, IT Infrastructure, Culture, and strategies) of the
proposed model can be used to evaluate the effects of people, organizations, technologies, and workflows
during the software development processes to obtain the required software quality. Finally, a
quantitative study will be implemented to investigate the proposed hypothesis and to measure factors
influencing the suggested model. By assessing to which degree these factors are present/ absent
within the SDLC process the managers will be able to address the weakness by preparing a suitable
plan and produce quality software.
Key Factors Affecting Ambulatory Care Providers’ Electronic Exchange of Health Information With Affiliated and Unaffiliated Partners: Web-Based Survey Study
Authors: Pendergrass John C , Chandrasekaran Ranganathan 
Published: December 2018

Background
Despite the potential benefits of electronic health information exchange (HIE) to improve the quality and efficiency of care, HIE use by ambulatory providers remains low. Ambulatory providers can greatly improve the quality of care by electronically exchanging health information with affiliated providers within their health care network as well as with unaffiliated, external providers.

Objective
This study aimed to examine the extent of electronic HIE use by ambulatory clinics with affiliated providers within their health system and with external providers, as well as the key technological, organizational, and environmental factors affecting the extent of HIE use within and outside the health system.

Methods
A Web-based survey of 320 ambulatory care providers was conducted in the state of Illinois. The study examined the extent of HIE usage by ambulatory providers with hospitals, clinics, and other facilities within and outside their health care system–encompassing seven kinds of health care data. Ten factors pertaining to technology (IT [information technology] Compatibility, External IT Support, Security & Privacy Safeguards), organization (Workflow Adaptability, Senior Leadership Support, Clinicians Health-IT Knowledge, Staff Health-IT Knowledge), and environment (Government Efforts & Incentives, Partner Readiness, Competitors and Peers) were assessed. A series of multivariate regressions were used to examine predictor effects.

Results
The 6 regressions produced adjusted R-squared values ranging from 0.44 to 0.63. We found that ambulatory clinics exchanged more health information electronically with affiliated entities within their health system as compared with those outside their health system. Partner readiness emerged as the most significant predictor of HIE usage with all entities. Governmental initiatives for HIE, clinicians’ prior familiarity and knowledge of health IT systems, implementation of appropriate security, and privacy safeguards were also significant predictors. External information technology support and workflow adaptability emerged as key predictors for HIE use outside a clinic’s health system. Differences based on clinic size, ownership, and specialty were also observed.

Conclusions
This study provides exploratory insights into HIE use by ambulatory providers within and outside their health care system and differential predictors that impact HIE use. HIE use can be further improved by encouraging large-scale interoperability efforts, improving external IT support, and redesigning adaptable workflows.
The Influence of Welding Ampere Range to ST-40 Shear Strength with Butt Joint
Authors: Winarno Rudi , Daryono Daryono , Jufri Moh. 
Published: December 2018

This experiment was conducted on the influence of welding process with ampere range variation and weld joints toward ST-40 shear strength. Furthermore, welded specimen is tested with tensile test. Method of this experiment is testing shear strength by using tensile testing machine where each five-specimens were previously welded by ampere range of 80 A, 90 A, and 100 A. Shear results show the highest shear strength is on 128.4916 N/mm2 with 80-ampere range on specimen no. 5, while on 90-ampere range variation the highest shear strength is on 124.7528 N/mm2, the specimen no. 5. Meanwhile, on 100-ampere range variation, the highest shear strength is on 120.1484 N/mm2, the specimen no. 4. The higher ampere (I) used, the higher heat (Q) resulted. When the heat increases, the welding electrode is perfectly fused. It makes good welding result achieved. The more strength on welding result, the higher shear strength (τ) achieved. On the other hand, the higher ampere range on welding process results higher shear strength.
PENGENDALIAN HAMA TERPADU (PHT) BIOINTENSIF PADA TANAMAN PADI DI DESA SENANING
Authors: Wilyus Wilyus , Ratna Yuni , Yunita Wilma 
Published: December 2018

Kegiatan pengabdian pada masyarakat (PPM) ini bertujuan untuk: meningkatkan pengetahuan, keterampilan dan kemampuan manajerial kelompok tani tentang pengendalian hama terpadu (PHT) biointensif; memecahkan masalah hama dan penyuakit tanaman padi melalui penerapan PHT biointensif. Kegitan ini akan dilaksanakan pada Kelompok Tani Hikmah Tani dan Kelompok Tani Payo Ddap di Desa Senaning Kecamatan Pemayung Kabupaten Batang Hari selama 6 bulan. Kegiatan dirancang berdasarkan pemahaman akan kondisi kelompok melalui participatory-rural-appraisal (PRA). Kegiatan akan dilaksanakan dengan penerapan metode androgogy dan partisipatry learning and action (PLA). Kegiatan yang dilaksanakan adalah: pelatihan peningkatan pengetahuan, keterampilan dan kemampuan manajerial kelompok tani tentang PHT biointensif; dan aplikasi penerapan PHT biointensif untuk mengendalikan hama dan penyakit padi. Materi pelatihan adalah: budidaya tanaman padi sehat; hama dan penyakit padi; pemantauan ekosistem padi; konservasi musuh alami; pemecahan masalah; dan PHT biointensif. Aplikasi penerapan PHT biointensif untuk mengendalikan hama dan penyakit padi akan dilakukan melalui peningkatan vigor/kesehatan tanamn padi dengan budidaya padi salibu; peningkatan peran musuh alami melalui konservasi, dan pengekangan perkembangan hama dan penyakit padi. Untuk menilai keberasilan pelaksanaan PPM akan dilakukan evaluasi. Evaluasi kegiatan dilakukan dengan penilaian pengetahuan, keterampilan dan kemampuan manajerial kelompok sasaran tentang PHT biointensif, keberhasilan usaha budidaya tanaman padi pada kelompok sasaran. Metode evaluasi dilakukan dengan penyebaran questioner di awal dan diakhir kegiatan, kemudian dianalisis secara diskriptif, serta membandingkan produksi dan keuntungan usaha budidaya tanaman padi yang diusahakan pada petak percontohan dengan produksi dan keuntungan usaha budidaya yang sama dilakukan oleh petani sebelumnya. Hasil yang sudah dicapai dari kegiatan ini adalah : 1) meningkatnya pengetahuan dan keterampilan teknis serta kemampuan manajerial kelompok tani tentang pengendalian hama terpadu (PHT) biointensiof pada tanaman padi; 2) petani mengerti tentang implementasi PHT biointensif dengan penerapan teknik budidaya padi salibu; 3) berkembangnya dinamika kelompok tani.
PEMBEKALAN ILMU DASAR GEOLOGI DALAM MENGEMBANGKAN JASA PEMANDU GEOWISATA DI DESA AIR BATU, KABUPATEN MERANGIN JAMBI
Authors: Said Yulia Morsa 
Published: December 2018

Geopark Merangin Jambi khususnya di kawasan Desa Air Batu merupakan objek wisata yang selalu dikunjungi oleh para wisatawan. Salah satu manfaat besarnya dalam kegiatan pembekalan ini adalah memberikan pengetahuan untuk pemandu agar dapat menjelaskan kepada wisatawan dan dengan pengetahuan geologi daerah mereka maka akan memberikan kesadaran dalam menjaga potensi geologi yang dimiliki. Situs geologi dan yang terkandung didalamnya di Desa Air Batu sangat menarik untuk diketahui dan menjadi tempat wisata geologi yang berkelas internasional karna potensi geologi yang terdapat disana.. Jadi, peranan HAMPA untuk dapat menjelaskan langsung dilapangan kepada para pengunjung dapat menjadi pelayanan yang baik bagi para mengunjung. Melihat hal ini, maka dirasa perlu untuk memberikan pembekalan mengenai geologi yang ada di sana untuk dapat menjelaskan kepada para pengunjung yang tidak mengetahui ilmu geologi, serta memberikan kesadaran bagi para pengunjung untuk menjaga situs warisan geologi yang ada di sana. Melalui program pengabdian kepada masyarakat ini diharapkan dapat memberikan sumbangan pengetahuan yang sangat berharga kepada pemandu HAMPA untuk menjadi pemandu dan penjaga dalam menjadikan kawasan Geopark Merangin Jambi menjadi objek wisata yang diminati dan dapat memberikan pelayanan yang baik bagi pengunjung berupa pengetahuan ilmu geologi di kawasan Geopark Merangin.
INTENDED CHANGE MASYARAKAT PELAKU INTEGRASI TERNAK HULTIKULTURA DALAM PENANGGULANGAN BENCANA ASAP DI LAHAN GAMBUT KECAMATAN KUMPEH ULU
Authors: Adriani Adriani , Andayani Jul , Hamzah Hamzah , Armando Yunta Gombang , Novianti Sri 
Published: December 2018

Setiap tahun wilayah kumpeh selalu mengalami kebakaran hutan yang berdapak pada banyaknya asap yang ditimbulkan, ditambah lagi kebiasaan masyarakat dalam pengolah lahan pertanian dengan membakar dengan alasan lebih mudah, murah dan sisa pembakaran bisa menjadi pupuk. Namun sebagian besar wilayahnya terdiri atas lahan gambut yang mudah terbakar jika terjadi kemarau dan api sulit dikendalikan. Tentunya ini menjadi masalah sekaligus tantangan untuk bisa merubah pola pengolahan lahan yang selama ini dilakukan kearah yang lebih baik (Intended-Change). Survei pendahuluan, wawancara dengan masyarakat dan kelompok tani di Kumpeh Ulu bahwa kebiasaan masyarakat sudah turun temurun dilakukan yaitu membakar lahan 1-3 minggu dengan cara menunpuk tanaman semak yang sudah ditebas, kemudian ditutup tanah dibagian atasnya dan dibakar sampai semua sisa tanaman habis. Namun karena lahanya berupa gambut, maka tanah bagian atas juga merupakan bahan yang siap terbakar. Padahal selama proses pebakaran ini terjadi pencemaran udara karena tingginya kandungan asap, sulit mengendalikan api jika sudah melebar. Potensi yang sangat menunjang dalam proses pengolahan lahan yang ramah lingkungan adalah melakukan pengolahan limbah kotoran ternak dan limbah tanaman yang ada menjadi pupuk organik. Karena selama ini petani peternak tidak mengetahui pengolahan kotoran ternak menjadi pupuk bahkan kotoran ternak yang ada dibuang begitu saja disekitar kandang yang juga mengakibatkan pencemaran udara dan air. Padahal jumlah ternak yang dimiliki kedua kelompok tani (sumber rezeki dan karya tani) tergolong banyak yaitu sapi 37 ekor dan kambing 66 ekor. Potensi kotoran dari ternak ini sekitar 851 kg per hari dalam bentuk basah dari sapi dan sebanyak ± 30 kg per hari dari kambing. Tentunya ini merupakan bahan baku yang bisa dimanfaatkan selain sisa atau limbah tanaman hultikutura yang ada. Kegiatan penyluhan dilakukan di rumah ketua kelompok sumber rezeki yang diikuti sebanyak 22 onggota kelompok tani. Materi yang diberikan pada kegiatan penyuluhan ada 3 yaitu karerateristik lahan gambut, proses pembuatan pupuk organik dari kotoran ternak dan hijauan serta materi dampak asap pembakaran terhadap kesehatan. Selain penyuluhan juga ada praktek pembuatan pupuk organik sebanyak 1 ton, dengan menggunakan 600 kg kotoran kambing, 400 kg rumput yang sudah dicacah, ditambah dengan 1 liter EM4, 5 kg dedak padi dan 2,5 kg urea. Semua bahan diaduk rata dan disimpan selama 21 hari dengan cara ditutup tarpal. Hasil evaluasi kegiatan pengabdian bahwa pupuk organik yang dihasilkan memperlihatkan bentuk fifik yang baik yaitu berwarna coklat sampai kehiataman, berbauk tanah dan bertektur gembur.