bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motivation in Rare Disease Self-Care: A Phenomenological Study of Pediatric Patients With Spinal Muscular Atrophy and Their Caregivers
Authors: YANG Bao-Huan , CHUNG Chia-Ying , LI Yuh-Shiow 
Published: December 2024

ABSTRACT

Background
Spinal muscular atrophy can cause progressive physical disability and difficulties with self-care. Self-care motivation can enhance patient persistence in self-care behavior and maintain health.

Purpose
This study was designed to explore and describe motivations for self-care among school-aged children and adolescents with spinal muscular atrophy and the perspectives of their primary caregivers.

Methods
Husserl's phenomenological research method was adopted, and data were collected using in-depth, face-to-face, open-ended interviews with patients and their primary caregivers aged 8–18 years with spinal muscular atrophy. A total of eight patient–caregiver dyads were recruited via purposeful sampling from a hospital clinic and through the Muscular Dystrophy Association of Taiwan. The interviews were conducted in the participants' homes and transcribed verbatim. Data were then thematically analyzed using the Giorgi analysis method.

Results
Six themes were identified from the patients' perspective: (a) adapting to dietary restrictions, (b) proactive measures for physical safety, c3) pursuing social connection and peer support, (d) navigating emotional well-being, (e) seeking independence, and (f) achieving success motivation. From the caregivers' perspective, the motivations for patient self-care were identified as follows: (a) ensuring safe and enjoyable eating for patients, (b) facilitating patient autonomy in health risk management, (c) facilitating patient engagement with peers, (d) balancing support with encouraging independence, (e) assessing and balancing independence and safety in patient caregiving, and (f) admiring patients' resilience and self-care innovation.

Conclusions/Implications for Practice
This study highlights the vital roles of caregivers in adapting to the dynamic self-care motivations of children and adolescents and of healthcare professionals in facilitating communication and care strategies. Personalized approaches are essential for enhancing autonomy and well-being in pediatric patients.
Exploring the Relationship Between Prolonged Grief and Borderline Personality Symptoms
Authors: Magoon Christopher , Shear M. Katherine 
Published: December 2024

Background:
Prolonged grief disorder (PGD) is a new diagnosis that is often mistaken for other psychopathologies. We report a case of PGD in a patient who screened positive for personality disorder. Both PGD and personality disorder symptoms were much improved after a course of prolonged grief disorder therapy.

Case Presentation:
A bereaved woman in her mid-20s sought treatment for depression 9 months after the death of her father. Her depressive symptoms responded well to antidepressant medication and a brief course of interpersonal psychotherapy. However, prolonged grief symptoms persisted at a clinically significant level. Elements of her history, as well as her score of 9 out of 10 on the McLean Screening Instrument for Borderline Personality Disorder, indicated a possible diagnosis of borderline personality disorder. Yet, after completing a course of prolonged grief disorder therapy, both her grief and borderline symptoms were much reduced.

Conclusions:
This case raises the possibility of an association between prolonged grief and borderline symptoms. Disruption of attachment relationships provides a possible way of understanding this association. The case we present raises the possibility that prolonged grief disorder may better explain symptoms in some patients presenting with borderline personality disorder symptoms.
Evaluating Quality and Readability of AI-generated Information on Living Kidney Donation
Authors: Villani Vincenzo , Nguyen Hong-Hanh T. , Shanmugarajah Kumaran 
Published: December 2024

Background.
The availability of high-quality and easy-to-read informative material is crucial to providing accurate information to prospective kidney donors. The quality of this information has been associated with the likelihood of proceeding with a living donation. Artificial intelligence–based large language models (LLMs) have recently become common instruments for acquiring information online, including medical information. The aim of this study was to assess the quality and readability of artificial intelligence-generated information on kidney donation.

Methods.
A set of 35 common donor questions was developed by the authors and used to interrogate 3 LLMs (ChatGPT, Google Gemini, and MedGPT). Answers were collected and independently evaluated using the CLEAR tool for (1) completeness, (2) lack of false information, (3) evidence-based information, (4) appropriateness, and (5) relevance. Readability was evaluated using the Flesch-Kincaid Reading Ease Score and the Flesch-Kincaid Grade Level.

Results.
The interrater intraclass correlation was 0.784 (95% confidence interval, 0.716-0.814). Median CLEAR scores were ChatGPT 22 (interquartile range [IQR], 3.67), Google Gemini 24.33 (IQR, 2.33), and MedGPT 23.33 (IQR, 2.00). ChatGPT, Gemini, and MedGPT had mean Flesch-Kincaid Reading Ease Scores of 37.32 (SD = 10.00), 39.42 (SD = 13.49), and 29.66 (SD = 7.94), respectively. Using the Flesch-Kincaid Grade Level assessment, ChatGPT had an average score of 12.29, Gemini had 10.63, and MedGPT had 13.21 (P < 0.001), indicating that all LLMs had a readability at the college-level education.

Conclusions.
Current LLM provides fairly accurate responses to common prospective living kidney donor questions; however, the generated information is complex and requires an advanced level of education. As LLMs become more relevant in the field of medical information, transplant providers should familiarize themselves with the shortcomings of these technologies.
Equity Landscape in Healthcare Quality: A Mixed-Methods Study of Efforts within Surgical Quality Programs
Authors: Liu Jessica K , Collins Courtney E , Moturu Anoosha , Pollitt Karen , Kao Lillian S , Mason Bonnie S , Nathens Avery , Ko Clifford Y 
Published: December 2024

Background:
Addressing equity in healthcare is necessary to improve population health outcomes. In doing so, a requisite level of foundational resources, organization, and processes are needed. Although increasing attention is being devoted to addressing health inequities, the current landscape supporting these efforts remains unknown. We sought to evaluate the presence of frontline resources, organization, and processes for support of health equity efforts in hospitals participating in American College of Surgeons’ (ACS) quality programs.

Study Design:
Using a mixed-methods design of online surveys and semi-structured interviews, we evaluated hospitals with ACS quality programs. Descriptive analytics were applied to survey results; interview transcripts were coded using an inductive approach. Data and methods were triangulated to report key findings.

Results:
Of the 44 programs invited, 36% completed the survey. Five site program leaders were interviewed. All program leaders reported having a strategy at the institution level for supporting equity efforts and having processes in place for reporting instances of discrimination, mistreatment, or harassment. Survey results demonstrated deficient workforce capacity, lack of engagement, and insufficient organization – negatively impacting efforts. The key themes from interviews were: 1) implementation occurred primarily and superficially at the institutional level, 2) barriers to implementation included preemptive structure, lack of prioritization, and insufficient disparities data, and 3) opportunities included enhancing leadership and staff buy-in, increasing available resources, developing health equity champions, and defining clear strategies.

Conclusions:
Efforts aimed at achieving health equity exist but lack the necessary infrastructure, organization, and processes to support effective frontline practices. The findings from this study support consideration of standards development targeting problems and opportunities at both the institutional and program level for advancing equity in quality improvement efforts.
Islamic banks and their conventional peers: an empirical investigation on 115 banks from MENA countries
Authors: Neifar Malika 
Published: December 2024

Purpose Exploiting a sample of 80 conventional banks (CBs) and 35 Islamic banks (IBs), this study aims to distinguish the IBs’ performance from their conventional peers in 7 Middel East and North Africa (MENA) economies over the period 2005–2014 covering the 2008 GFC.Design/methodology/approach To avoid misleading results, this research used panel-corrected data from outliers effects by quantile method. Then, following the use of the two-sided Student’s t-test and the discriminant function analysis (DFA), we adopt nonlinear panel models (Random Logit and Pooled Probit) to further distinguish between banks. Then, we focus on the stability side through dynamic Generalized method of moment (GMM) linear models and interaction variables to capture the 2008 global financial crisis (GFC) impact on IB performance.Findings Univariate tests show that IBs are, on average, less profitable, more liquid and capitalized, less stable, have higher credit risk and are more solvent than CBs. In addition, the difference between the two types of banks was significant pre- and post-GFC; IBs are more profitable pre-GFC and more solvent post-GFC. In accordance with the univariate t-test results, the nonlinear pooled probit model (random logit) confirms that banks, which have more liquidity, are better capitalized, more solvent and less stable (less stable) are more likely to be IBs. From the DFA, stability was the first financial ratio important to discriminate between the two types of banks. In line with the DFA results, from the dynamic models, once the interaction variables are integrated, the GMM estimation result suggests that stronger macroeconomic stability and higher profitability, capital adequacy ratio (CAP) and liquidity are linked to increased IBs stability in the 7 MENA economies post-2008 GFC.Originality/value The present study contributes to the ongoing debate by conducting a formal empirical analysis, taking account of a range of considerations (outliers correction, interaction variables and 2008 GFC impacts) that to the best of our knowledge have not been considered by prior studies for the MENA zone.
For Palestine or for us too? Examining Indonesian youth’s willingness to buy local products amid the Israel boycott
Authors: Herani Rina , Angela Jovita 
Published: December 2024

Purpose
The aim of this study is to explore the drivers behind the willingness of Indonesian youth to buy local products as an alternative to Israeli-affiliated products amid geopolitical tensions between Palestine and Israel, using the framework of identity-based motivation theory.

Design/methodology/approach
This study uses SmartPLS 4 to examine the proposed hypotheses using survey data collected from 307 Indonesian youth, within the context of an ongoing Israel boycott. This dynamic setting allows us to capture real-time and authentic responses of Indonesian youth to socio-political pressures and religious endorsements in their purchasing decisions.

Findings
The findings challenge the belief that religious altruism alone drives Indonesian youth to buy local products during the Israel boycott. Instead, those with strong religious and ethnocentric values are more likely to support local industries when they believe in the effectiveness of boycotting Israeli-affiliated products.

Practical implications
The findings offer valuable insights for domestic marketers, policymakers, educators and communities seeking to strengthen local industries in the face of geopolitical tensions.

Originality/value
This study contributes to the underexplored area of local product consumption by integrating religious, geopolitical and national identity factors through the lens of identity-based motivation theory, offering a novel perspective on the motivational drivers behind Indonesian youth’s willingness to buy local products during a boycott.
Velocity model building via combining seismic slope tomography and supervised deep learning
Authors: Huang Yao , Yang Huachen , Zhang Jianzhong 
Published: December 2024

AbstractSeismic slope tomography is an effective method to build macro velocity model. In order to improve the accuracy and resolution of the slope tomography, we proposed a novel approach that combines slope tomography with supervised deep learning. First, the slope tomography is used to obtain the macro velocity model and the positions of reflection points. Subsequently, the slope tomographic model, positions of reflection points and the corresponding observed traveltimes are used as inputs simultaneously for a neural network, whereas the actual velocity models are used as the labels. Through training the neural network with sufficient samples, the mapping from the inputs to the real velocity model is established. The neural network learns the background velocity of the real model from the smooth tomographic model, the velocity details from the traveltimes and the formation interface information from the positions of reflection points. Consequently, a high‐accuracy and high‐resolution velocity model is obtained on the basis of the slope tomographic model. Both tests on synthetic seismic data and applications to field seismic data demonstrate the effectiveness of the proposed method.
The Impact of Early Diagenesis on Biosignature Preservation in Sulfate Evaporites: Insights From Messinian (Late Miocene) Gypsum
Authors: Pellegrino Luca , Natalicchio Marcello , Cotellucci Andrea , Genre Andrea , Jordan Richard W. , Carnevale Giorgio , Dela Pierre Francesco 
Published: December 2024

ABSTRACTDue to their fast precipitation rate, sulfate evaporites represent excellent repositories of past life on Earth and potentially on other solid planets. Nevertheless, the preservation potential of biogenic remains can be compromised by extremely fast early diagenetic processes. The upper Miocene, gypsum‐bearing sedimentary successions of the Mediterranean region, that formed ca. 6 million years ago during the Messinian salinity crisis, represent an excellent case study for investigating these diagenetic processes at the expense of organic matter and associated biominerals. Several gypsum crystals from the Northern Mediterranean were studied by means of destructive and non‐destructive techniques in order to characterize their solid inclusion content and preservation state. In the same crystal, excellently preserved microfossils coexist with strongly altered biogenic remains. Altered remains are associated with authigenic minerals, especially clays. The results demonstrate that a significant fraction of organic matter and associated biominerals (notably biogenic silica) underwent early diagenetic modification. The latter was likely triggered by bottom sulfidic conditions when the growth of gypsum was interrupted. These results have significant implications for the interpretation of the Messinian Salt Giant.
The Urban Hospitalisation Experience of Rural People: A Scoping Review
Authors: Aquino Jose , Marshall Andrea P. , Ranse Kristen , Mills Kyly 
Published: December 2024

ABSTRACTBackgroundHospitalisation is often typically a stressful experience, but in the face of admission into hospital at a distance from home, the experience can be particularly anxiety‐provoking.Aim(s)To describe the urban hospitalisation experiences of rural patients and their relatives who have travelled and relocated for treatment and determine the scope and coverage of the literature on this issue.DesignThe review utilises a scoping review method. CINAHL, MEDLINE, PsycINFO and EMBASE were searched for primary studies dated from inception to October, 2022. Thirty‐four articles were included in the review. Using an inductive narrative approach, data were extracted, collated and summarised into key themes.ResultsSix themes were identified: Rural Indigenous peoples' experience, the promise of urban quality, separation from support networks, interactions with staff, managing out‐of‐hospital responsibilities and transitioning home.ConclusionUnderpinned by isolation and unfamiliarity, hospitalisation away from one's local community entails significant psychological stress that compounds the stresses of illness that require admission into the hospital.Implications for the Profession and/or Patient CareFindings demonstrate the dynamic nature of the healthcare encounter, illustrating the multiplicity of the experience and how some aspects of the experience cut across others.ImpactThis scoping review conceptualises the urban hospitalisation experiences of rural people and illustrates the impact of isolation and unfamiliarity on their in‐hospital behaviours, perceptions and interactions.Reporting MethodPRISMA Extension for Scoping Reviews (PRISMA‐ScR).Patient or Public ContributionNo Patient or Public Contribution.
COL10A1 Facilitates Prostate Cancer Progression by Interacting With INHBA to Activate the PI3K/AKT Pathway
Authors: Jiang Kun , Xu Li‐zhe , Cheng Fan , Ning Jin‐zhuo 
Published: December 2024

ABSTRACTProstate cancer (PCa) constitutes a highly common and lethal disease that impacts males globally. However, the specific molecular pathways responsible for its development are still unknown. Therefore, revealing the molecular regulators that contributed to the progression of PCa is pivotal for developing unique management strategies. Through comprehensive bioinformatics analysis of multiple public gene databases, we thoroughly investigated COL10A1 expression level, clinical significance, co‐expressed genes and signalling pathways in PCa. COL10A1 and INHBA expression level was assessed in clinical PCa specimens using RT‐qPCR, Western blotting and immunohistochemistry. A combination of experimental techniques, including CCK‐8 assay, colony formation, flow cytometry, Transwell, wound‐healing, immunoprecipitation assays and rescue study, was utilised to examine the fundamental molecular pathways of COL10A1's action across PCa. The COL10A1 expression was significantly elevated in PCa, and its upregulation has been connected with tumour aggressiveness and a weak predictive outcome in subjects. The current investigation revealed that regulation of COL10A1 expression, either by upregulation or downregulation, resulted in sequential augmentation or suppression of PCa cell progression, migration and invasion. Mechanistically, COL10A1 was manifested to directly interact with INHBA and facilitate PI3K and AKT phosphorylation pathways within PCa cells and mouse models. The results of our study offer new perspectives on the tumorigenic role of COL10A1 in PCa and its interactions with INHBA may play important roles in PCa progression.
Contradictory Role of Gadd45β in Liver Diseases
Authors: Wu Chi , Song Xiaozhen , Zhang Miaoxin , Yang Longjun , Lu Panpan , Ding Qiang , Liu Mei 
Published: December 2024

ABSTRACTThere are three homologous proteins (α, β and γ) in the growth arrest and DNA damage 45 (Gadd45) family. These proteins act as cellular responders to physiological and environmental stimuli. Gadd45β plays a significant role in the pathogenesis of liver diseases. Liver injury and growth stimulation increase expression of Gadd45β, which promotes cell survival, growth and proliferation in normal liver cells. By contrast, Gadd45β plays a role in promoting apoptosis and inhibiting tumour function in hepatocellular carcinoma (HCC). Currently, it is believed that Gadd45β benefits the liver through two different pathways: binding to MAPK kinase 6 (MKK6) to increase PCD induced by p38 (inhibiting tumours) or binding to constitutive androstane receptor (CAR) to jointly activate transcription of liver synthesis metabolism (promoting liver regeneration). This article aims to systematically review the role of Gadd45β in liver diseases, including its regulatory mechanism on expression and involvement in liver cell damage, inflammation, fibrosis and HCC. In conclusion, we explore the potential of targeting Gadd45β as a therapeutic strategy for liver diseases.
Aryl Hydrocarbon Receptor Alleviates Hepatic Fibrosis by Inducing Hepatic Stellate Cell Ferroptosis
Authors: Liu Shenghui 
Published: December 2024

ABSTRACTLiver injury‐induced activation of hepatic stellate cells (HSCs) is a crucial step in the progression of liver fibrosis. The aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor, is highly expressed in the liver. However, the role of AHR in liver fibrosis remains controversial. Our study revealed that the nontoxic ligand YH439 directly activated the AHR and regulated the expression of multidrug‐resistant protein 1 (Mrp1) in mouse hepatic stellate cells (mHSCs), thereby diminishing the antioxidant capacity of mHSCs by promoting GSH efflux, and specifically inducing mHSCs ferroptosis without affecting hepatocytes. In a chronic liver fibrosis model, YH439 activated AHR to promote mHSC ferroptosis without causing hepatocyte ferroptosis, thereby alleviating liver fibrosis. Conclusively, this study shows that AHR alleviates liver fibrosis in mice by selectively inducing mHSC ferroptosis without causing hepatocyte ferroptosis and suggests that AHR is a potential target for the treatment of liver fibrosis.
Towards affordable biomedical imaging: Recent advances in low‐cost, high‐resolution optoacoustic microscopy
Authors: Kalitsounakis Pavlos , Zacharakis Giannis , Tserevelakis George J. 
Published: December 2024

AbstractThis short review discusses the recent developments in low‐cost, high‐resolution optoacoustic microscopy systems, integrating laser diodes for signal excitation, which are 20–40 times cheaper than the typically employed Q‐switched nanosecond laser sources. The development of laser diode‐based microscopes can substantially improve not only cost efficiency, but also multispectral capabilities, robustness, portability and overall imaging performance of the optoacoustic technique. To this end, we demonstrate relevant implementations in both time and frequency domain, highlighting their representative applications in biomedical research such as microvasculature imaging, oxygen saturation assessments, hybrid and multiview microscopy of model organisms and tissues and Doppler flow speed measurements. Finally, we analyse the benefits and limitations of each approach, identifying the respective application contexts where they achieve optimum performance.
Primary Care Referral Delays in Oral Cancer Diagnosis: A Meta‐Analysis
Authors: Romero Juan Manuel Seoane , Mallah Narmeen , Varela‐Centelles Pablo Ignacio , Warnakulasuriya Saman , Takkouche Bahi 
Published: December 2024

ABSTRACTObjectiveTo measure the primary care interval (PCI) in the diagnostic delay of oral cancer and to assess the relation of the referring physician's specialty with disease stage at diagnosis.MethodsWe meta‐analyzed reports of oral/oropharyngeal carcinomas detailing PCI start‐ and endpoints, i.e., the time needed by a primary care physician to refer a suspected oral cancer patient to a specialist.Results17 studies with a total of 2530 patients were eligible; nine provided data on the relative length of PCI, and 10 reported on the impact of the referring professional's specialty on oral cancer diagnostic delay. The average PCI length was slightly longer for general practitioners (GPs) (30.5 days) than for general dental practitioners (GDPs) (27.6 days), while that for the total group was 28.7 days. One‐third of the total pre‐hospital time spent on diagnosis elapses in GP practices (PCI%: 0.31 [95% CI: 0.23, 0.40]). GDPs refer their patients for treatment at earlier disease stages (TNM I‐II) than GPs (Odds Ratio: 0.58; 95% CI: 0.34–0.98).ConclusionsPrimary care accounts for a considerable pre‐hospital amount of time of what is necessary for reaching a diagnosis of oral cancer patients. This calls for enhancing early oral cancer recognition in primary care settings.