bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of an antibiotic spectrum index in the neonatal intensive care unit
Authors: Lahart Alexandra C. , McPherson Christopher C. , Gerber Jeffrey S. , Warner Barbara B. , Lee Brian R. , Newland Jason G. 
Published: July 2019

AbstractAntimicrobial stewardship programs typically use days of therapy to assess antimicrobial use. However, this metric does not account for the antimicrobial spectrum of activity. We applied an antibiotic spectrum index to a population of very-low-birth-weight infants to assess its utility to evaluate the impact of antimicrobial stewardship interventions.
Surface and basal boundary conditions at the Southern McMurdo and Ross Ice Shelves, Antarctica
Authors: GRIMA C. , KOCH I. , GREENBAUM J. S. , SODERLUND K. M. , BLANKENSHIP D. D. , YOUNG D. A. , SCHROEDER D. M. , FITZSIMONS S. 
Published: July 2019

ABSTRACTWe derive the surface and basal radar reflectance and backscatter coefficients of the southern McMurdo Ice Shelf (SMIS) and part of the nearby Ross Ice Shelf (RIS), Antarctica, from radar statistical reconnaissance using a 60-MHZ airborne survey. The surface coefficients are further inverted in terms of snow density and roughness, providing a spatial distribution of the processes contributing to the surface boundary conditions. We disentangle the basal coefficients from surface transmission losses, and we provide the basal coherent content, an indicator of the boundary geometric disorder that is also self-corrected from englacial attenuation. The basal radar properties exhibit sharp gradients along specific iso-depths, suggesting an abrupt modification of the ice composition and geometric structure. We interpret this behavior as locations where the pressure-melting point is reached, outlining fields of freezing and melting ice. Basal steps are observed at both SMIS and RIS, suggesting a common geometric expression of widespread basal processes. This technique offers a simultaneous view of both the surface and basal boundary conditions to help investigate the ice-shelf stability, while its application to airborne data significantly improves coverage of the difficult-to-observe ice–ocean boundary. It also provides constraints on thermohaline circulation in ice shelves cavities, which are analogs for ice-covered ocean worlds.
Electoral competition after party splits
Authors: Ibenskas Raimondas 
Published: July 2019

AbstractWhile party splits are a relatively frequent phenomenon in many new and established democracies, the systematic empirical research on electoral competition after schisms is limited. The analysis of more than 200 splits across 25 European countries in the post-war period addresses this gap in the research. The study shows that the vote shares of rump and splinter parties in the first election after fission are related to their membership strength and the share of splinter legislators. This relationship is present in both Western Europe and Central and Eastern Europe. Additionally, economic growth affects the support of rump parties that hold government office while party system fragmentation and party funding regulations correlate with the electoral performance of splinter parties.
Morphosyntactic and morphophonological variation in Breton: a cross-generational perspective
Authors: Kennard Holly 
Published: July 2019

AbstractLike France’s other regional languages, Breton has seen a steep decline, followed by a period of revitalization in recent decades. Today there are two largely separate communities of speakers: older, traditional speakers who grew up speaking Breton at home, and younger speakers, generally from French-speaking homes, most of whom have learnt Breton through immersion schooling. It is claimed that this ‘Neo-Breton’ differs from the language of older speakers, lexically, phonologically and grammatically. This article examines morphosyntactic (impersonal) and morphophonological (mutation) data to explore exactly how Neo-Breton differs from that of traditional speakers, and how the variability in the data might be explained. The data show that contrary to what might be expected, new speakers do not differ greatly from older, traditional speakers in these areas. Influence from French is more subtle than might be supposed. Children and teenagers who attend Breton-medium schooling seem to show an extended period of acquisition, but the data from adult new speakers suggests that with enough Breton input, these young speakers can reach full proficiency. However, as the number of older speakers decreases, Breton seems likely to see more widespread language change.
Quizalofop interactions when mixed with clomazone and pendimethalin in acetyl coenzyme A carboxylase–inhibiting herbicide-resistant rice
Authors: Osterholt Matthew J. , Webster Eric P. , Blouin David C. , McKnight Benjamin M. 
Published: July 2019

AbstractA study was conducted in 2017 and 2018 at the H. Rouse Caffey Rice Research Station near Crowley, LA, to evaluate quizalofop at 120 g ai ha−1 applied independently or in a mixture with clomazone, pendimethalin, clomazone plus pendimethalin, or a prepackaged mixture of clomazone plus pendimethalin when PVLO1 rice reached the two- to three-leaf stage. A second application of quizalofop at 120 g ha−1 was applied 21 d after the initial application. At 7 days after treatment (DAT), antagonism of quizalofop occurred when mixed with clomazone at 334 g ai ha−1, clomazone at 334 g ai ha−1 plus pendimethalin at 810 g ai ha−1, or a prepackaged mixture of clomazone plus pendimethalin at 334 plus 810 g ai ha−1, respectively, when applied to barnyardgrass. At 7 DAT, a neutral interaction occurred with a mixture of quizalofop plus pendimethalin at 810 g ha−1. These data indicate the antagonism of quizalofop was overcome at 14, 28, and 42 DAT with a neutral interaction for barnyardgrass control, 94% to 98%, with all herbicide mixtures evaluated. A neutral interaction occurred for CL-111, CLXL-745, and red rice control when treated with all the herbicide mixtures evaluated across all evaluation dates. Rice yield decreased when not treated with the initial quizalofop application.
The Decadal Variability of the Global Monsoon Links to the North Atlantic Climate Since 1851
Authors: Han Tao , Yu Kefu , Yan Hong , Yan Hongqiang , Tao Shichen , Zhang Huiling , Wang Shaopeng , Chen Tegu 
Published: July 2019

AbstractTo date, the decadal variability of the Global Monsoon (GM) has been mainly studied using instrumental data collected over the last 50 years, and further discussion has been hampered by the limited data length. Here, we present a coral δ18O record from the northern South China Sea, where the hydrology is related to the seasonal Intertropical Convergence Zone (ITCZ) migration, and we use this record to reconstruct the decadal migration of the ITCZ since 1851 A.D. Combining our record with a synthesis of monsoon records reveals an anti‐phase inter‐hemispheric variability of the GM over the last 150 years, indicating that the decadal‐scale hydrologic variability in the tropics is modulated by the meridional migration of the ITCZ. The plausible relationship observed between the decadal variability of the GM and the Atlantic Multidecadal Oscillation suggests that the decadal variability of tropical hydrological changes is likely linked to the climate perturbations in the North Atlantic.
Source Model for the Tsunami Inside Palu Bay Following the 2018 Palu Earthquake, Indonesia
Authors: Gusman Aditya Riadi , Supendi Pepen , Nugraha Andri Dian , Power William , Latief Hamzah , Sunendar Haris , Widiyantoro Sri , Daryono  , Wiyono Samsul Hadi , Hakim Aradea , Muhari Abdul , Wang Xiaoming , Burbidge David , Palgunadi Kadek , Hamling Ian , Daryono Mudrik Rahmawan 
Published: July 2019

AbstractOn 28 September 2018, a strike‐slip earthquake occurred in Palu, Indonesia, and was followed by a series of tsunami waves that devastated the coast of Palu Bay. The tsunami was recorded at the Pantoloan tide gauge station with a peak amplitude of ~2 m above the water level and struck at high tide. We use the Pantoloan tsunami waveform and synthetic aperture rada displacement data in a joint inversion to estimate the vertical displacement around the narrow bay. Our inversion result suggests that the middle of the bay was uplifted up to 0.8 m, while the other parts of the bay subsided by up to 1 m. However, this seafloor displacement model alone cannot fully explain the observed tsunami inundation. The observed tsunami inundation heights and extents could be reproduced by a tsunami inundation simulation with a source model that combined the estimated vertical displacement with multiple subaerial‐submarine landslides.
Magnetic Reconnection in a Quasi‐Parallel Shock: Two‐Dimensional Local Particle‐in‐Cell Simulation
Authors: Bessho N. , Chen L.‐J. , Wang S. , Hesse M. , Wilson L. B. 
Published: July 2019

AbstractMagnetic reconnection in a quasi‐parallel bow shock is investigated with two‐dimensional local particle‐in‐cell simulations. In the shock transition and downstream regions, large amplitude magnetic fluctuations exist, and abundant current sheets form. In some current sheets, reconnection occurs, and ion‐scale and electron‐scale magnetic islands are generated. In electron‐scale island regions, only electron outflow jets are observed, producing a quadrupolar out‐of‐plane magnetic field pattern, while in ion‐scale islands, both ions and electrons are involved and energized in reconnection. Normalized reconnection rates are obtained to be between around 0.1 to 0.2, and particle acceleration signatures are seen in distribution functions.
Global Variability of Optical Backscattering by Non‐algal particles From a Biogeochemical‐Argo Data Set
Authors: Bellacicco M. , Cornec M. , Organelli E. , Brewin R. J. W. , Neukermans G. , Volpe G. , Barbieux M. , Poteau A. , Schmechtig C. , D'Ortenzio F. , Marullo S. , Claustre H. , Pitarch J. 
Published: July 2019

AbstractUnderstanding spatial and temporal dynamics of non‐algal particles in open ocean is of the utmost importance to improve estimations of carbon export and sequestration. These particles covary with phytoplankton abundance but also accumulate independently of algal dynamics. The latter likely represents an important fraction of organic carbon, but it is largely overlooked. A possible way to study these particles is via their optical backscattering properties (bbp) and relationship with chlorophyll‐a (Chl). To this aim, we estimate the fraction of bbp associated with the non‐algal particle portion (
) that does not covary with Chl by using a global Biogeochemical‐Argo data set. We quantify the spatial, temporal, and vertical variability of
. In the northern productive areas,
is a small fraction of bbp and shows a clear seasonal cycle. In the Southern Ocean, bkbp is a major fraction of total bbp. In oligotrophic areas,
has a smooth annual cycle.
Atmospheric carbon monoxide oxidation is a widespread mechanism supporting microbial survival
Authors: Cordero Paul R F , Bayly Katherine , Man Leung Pok , Huang Cheng , Islam Zahra F , Schittenhelm Ralf B , King Gary M , Greening Chris 
Published: July 2019

Abstract
Carbon monoxide (CO) is a ubiquitous atmospheric trace gas produced by natural and anthropogenic sources. Some aerobic bacteria can oxidize atmospheric CO and, collectively, they account for the net loss of ~250 teragrams of CO from the atmosphere each year. However, the physiological role, genetic basis, and ecological distribution of this process remain incompletely resolved. In this work, we addressed these knowledge gaps through culture-based and culture-independent work. We confirmed through shotgun proteomic and transcriptional analysis that the genetically tractable aerobic soil actinobacterium Mycobacterium smegmatis upregulates expression of a form I molydenum–copper carbon monoxide dehydrogenase by 50-fold when exhausted for organic carbon substrates. Whole-cell biochemical assays in wild-type and mutant backgrounds confirmed that this organism aerobically respires CO, including at sub-atmospheric concentrations, using the enzyme. Contrary to current paradigms on CO oxidation, the enzyme did not support chemolithoautotrophic growth and was dispensable for CO detoxification. However, it significantly enhanced long-term survival, suggesting that atmospheric CO serves a supplemental energy source during organic carbon starvation. Phylogenetic analysis indicated that atmospheric CO oxidation is widespread and an ancestral trait of CO dehydrogenases. Homologous enzymes are encoded by 685 sequenced species of bacteria and archaea, including from seven dominant soil phyla, and we confirmed genes encoding this enzyme are abundant and expressed in terrestrial and marine environments. On this basis, we propose a new survival-centric model for the evolution of aerobic CO oxidation and conclude that, like atmospheric H2, atmospheric CO is a major energy source supporting persistence of aerobic heterotrophic bacteria in deprived or changeable environments.
Comparative characterization of human induced pluripotent stem cells (hiPSC) derived from patients with schizophrenia and autism
Authors: Grunwald Lena-Marie , Stock Ricarda , Haag Kathrina , Buckenmaier Sandra , Eberle Mark-Christian , Wildgruber Dirk , Storchak Helena , Kriebel Martin , Weißgraeber Stephanie , Mathew Lisha , Singh Yasmin , Loos Maarten , Li Ka Wan , Kraushaar Udo , Fallgatter Andreas J. , Volkmer Hansjürgen 
Published: July 2019

AbstractHuman induced pluripotent stem cells (hiPSC) provide an attractive tool to study disease mechanisms of neurodevelopmental disorders such as schizophrenia. A pertinent problem is the development of hiPSC-based assays to discriminate schizophrenia (SZ) from autism spectrum disorder (ASD) models. Healthy control individuals as well as patients with SZ and ASD were examined by a panel of diagnostic tests. Subsequently, skin biopsies were taken for the generation, differentiation, and testing of hiPSC-derived neurons from all individuals. SZ and ASD neurons share a reduced capacity for cortical differentiation as shown by quantitative analysis of the synaptic marker PSD95 and neurite outgrowth. By contrast, pattern analysis of calcium signals turned out to discriminate among healthy control, schizophrenia, and autism samples. Schizophrenia neurons displayed decreased peak frequency accompanied by increased peak areas, while autism neurons showed a slight decrease in peak amplitudes. For further analysis of the schizophrenia phenotype, transcriptome analyses revealed a clear discrimination among schizophrenia, autism, and healthy controls based on differentially expressed genes. However, considerable differences were still evident among schizophrenia patients under inspection. For one individual with schizophrenia, expression analysis revealed deregulation of genes associated with the major histocompatibility complex class II (MHC class II) presentation pathway. Interestingly, antipsychotic treatment of healthy control neurons also increased MHC class II expression. In conclusion, transcriptome analysis combined with pattern analysis of calcium signals appeared as a tool to discriminate between SZ and ASD phenotypes in vitro.
Nano-bio interactions: a neutrophil-centric view
Authors: Keshavan Sandeep , Calligari Paolo , Stella Lorenzo , Fusco Laura , Delogu Lucia Gemma , Fadeel Bengt 
Published: July 2019

AbstractNeutrophils are key components of the innate arm of the immune system and represent the frontline of host defense against intruding pathogens. However, neutrophils can also cause damage to the host. Nanomaterials are being developed for a multitude of different purposes and these minute materials may find their way into the body through deliberate or inadvertent exposure; understanding nanomaterial interactions with the immune system is therefore of critical importance. However, whereas numerous studies have focused on macrophages, less attention is devoted to nanomaterial interactions with neutrophils, the most abundant leukocytes in the blood. We discuss the impact of engineered nanomaterials on neutrophils and how neutrophils, in turn, may digest certain carbon-based materials such as carbon nanotubes and graphene oxide. We also discuss the role of the corona of proteins adsorbed onto the surface of nanomaterials and whether nanomaterials are sensed as pathogens by cells of the immune system.
CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression
Authors: Luo Yanwei , Fu Yunfeng , Huang Rong , Gao Meng , Liu Fengxia , Gui Rong , Nie Xinmin 
Published: July 2019

AbstractHepatocellular carcinoma (HCC) is one of the most common malignant tumors and a leading cause of cancer-related deaths worldwide. Emerging studies have shown that circular RNAs (circRNAs) are differentially expressed in HCC and play an important role in HCC pathogenesis and metastasis. However, the mechanism of circRNA in the chemoresistance of HCC remains unclear. In this study, we aimed to investigate the role of circRNA in cisplatin resistance of HCC. We identified a novel circRNA circRNA_101505 that was decreased in cisplatin-resistant HCC tissues and cell lines, and associated with a poor survival outcome. Gain-of-function investigations showed that overexpression of circRNA_101505 suppressed cancer cell growth in vivo and in vitro, and enhanced cisplatin toxicity in HCC cells. Mechanistic studies found that circRNA_101505 could sensitize HCC cells to cisplatin by sponging miR-103, and thereby promoting oxidored-nitro domain-containing protein 1 (NOR1) expression. In conclusion, the significant inhibitory effects indicate circRNA_101505 to be a potential therapeutic target for HCC treatment. Our findings provide significant evidence to further elucidate the therapeutic use of circRNA in HCC.
Disturbance modifies payoffs in the explore-exploit trade-off
Authors: O’Farrell Shay , Sanchirico James N. , Spiegel Orr , Depalle Maxime , Haynie Alan C. , Murawski Steven A. , Perruso Larry , Strelcheck Andrew 
Published: July 2019

AbstractDecision-making agents face a fundamental trade-off between exploring new opportunities with risky outcomes versus exploiting familiar options with more certain but potentially suboptimal outcomes. Although mediation of this trade-off is essential to adaptive behavior and has for decades been assumed to modulate performance, the empirical consequences of human exploratory strategies are unknown beyond laboratory or theoretical settings. Leveraging 540,000 vessel position records from 2494 commercial fishing trips along with corresponding revenues, here we find that during undisturbed conditions, there was no relationship between exploration and performance, contrary to theoretical predictions. However, during a major disturbance event which closed the most-utilized fishing grounds, explorers benefited significantly from less-impacted revenues and were also more likely to continue fishing. We conclude that in stochastic natural systems characterized by non-stationary rewards, the role of exploration in buffering against disturbance may be greater than previously thought in humans.
Microstructural control suppresses thermal activation of electron transport at room temperature in polymer transistors
Authors: Luzio Alessandro , Nübling Fritz , Martin Jaime , Fazzi Daniele , Selter Philipp , Gann Eliot , McNeill Christopher R. , Brinkmann Martin , Hansen Michael Ryan , Stingelin Natalie , Sommer Michael , Caironi Mario 
Published: July 2019

AbstractRecent demonstrations of inverted thermal activation of charge mobility in polymer field-effect transistors have excited the interest in transport regimes not limited by thermal barriers. However, rationalization of the limiting factors to access such regimes is still lacking. An improved understanding in this area is critical for development of new materials, establishing processing guidelines, and broadening of the range of applications. Here we show that precise processing of a diketopyrrolopyrrole-tetrafluorobenzene-based electron transporting copolymer results in single crystal-like and voltage-independent mobility with vanishing activation energy above 280 K. Key factors are uniaxial chain alignment and thermal annealing at temperatures within the melting endotherm of films. Experimental and computational evidences converge toward a picture of electrons being delocalized within crystalline domains of increased size. Residual energy barriers introduced by disordered regions are bypassed in the direction of molecular alignment by a more efficient interconnection of the ordered domains following the annealing process.
Error-correcting dynamics in visual working memory
Authors: Panichello Matthew F. , DePasquale Brian , Pillow Jonathan W. , Buschman Timothy J. 
Published: July 2019

AbstractWorking memory is critical to cognition, decoupling behavior from the immediate world. Yet, it is imperfect; internal noise introduces errors into memory representations. Such errors have been shown to accumulate over time and increase with the number of items simultaneously held in working memory. Here, we show that discrete attractor dynamics mitigate the impact of noise on working memory. These dynamics pull memories towards a few stable representations in mnemonic space, inducing a bias in memory representations but reducing the effect of random diffusion. Model-based and model-free analyses of human and monkey behavior show that discrete attractor dynamics account for the distribution, bias, and precision of working memory reports. Furthermore, attractor dynamics are adaptive. They increase in strength as noise increases with memory load and experiments in humans show these dynamics adapt to the statistics of the environment, such that memories drift towards contextually-predicted values. Together, our results suggest attractor dynamics mitigate errors in working memory by counteracting noise and integrating contextual information into memories.
Realizing nearly-free-electron like conduction band in a molecular film through mediating intermolecular van der Waals interactions
Authors: Cui Xingxia , Han Ding , Guo Hongli , Zhou Linwei , Qiao Jingsi , Liu Qing , Cui Zhihao , Li Yafei , Lin Chungwei , Cao Limin , Ji Wei , Petek Hrvoje , Feng Min 
Published: July 2019

AbstractCollective molecular physical properties can be enhanced from their intrinsic characteristics by templating at material interfaces. Here we report how a black phosphorous (BP) substrate concatenates a nearly-free-electron (NFE) like conduction band of a C60 monolayer. Scanning tunneling microscopy reveals the C60 lowest unoccupied molecular orbital (LUMO) band is strongly delocalized in two-dimensions, which is unprecedented for a molecular semiconductor. Experiment and theory show van der Waals forces between C60 and BP reduce the inter-C60 distance and cause mutual orientation, thereby optimizing the π-π wave function overlap and forming the NFE-like band. Electronic structure and carrier mobility calculations predict that the NFE band of C60 acquires an effective mass of 0.53–0.70 me (me is the mass of free electrons), and has carrier mobility of ~200 to 440 cm2V−1s−1. The substrate-mediated intermolecular van der Waals interactions provide a route to enhance charge delocalization in fullerenes and other organic semiconductors.