Rural–urban disparities in mortality of patients with acute myocardial infarction and heart failure: a systematic review and meta-analysis
Authors: Faridi Babar , Davies Steven , Narendrula Rashmi , Middleton Allan , Atoui Rony , McIsaac Sarah , Alnasser Sami , Lopes Renato D , Henderson Mark , Healey Jeff S , Ko Dennis T , Shurrab Mohammed 
Published: October 2024

Abstract

Aims
Patients with cardiac disease living in rural areas may face significant challenges in accessing care, and studies suggest that living in rural areas may be associated with worse outcomes. However, it is unclear whether rural–urban disparities have an impact on mortality in patients presenting with acute myocardial infarction (AMI) and heart failure (HF). This meta-analysis aimed to assess differences in mortality between rural and urban patients presenting with AMI and HF.

Methods and results
A systematic search of the literature was performed using PubMed, Embase, MEDLINE, and CENTRAL for all studies published until 16 January 2024. A grey literature search was also performed using a manual web search. The following inclusion criteria were applied: (i) studies must compare rural patients to urban patients presenting to hospital with AMI or HF, and (ii) studies must report on mortality. The primary outcome was all-cause mortality. Comprehensive data were extracted including study design, patient characteristics (sex, age, and comorbidities), sample size, follow-up period, and outcomes. Odds ratios (ORs) were pooled with fixed-effects model. A subgroup analysis was performed to investigate causes for heterogeneity in which studies were separated based on in-hospital mortality, post-discharge mortality, and region of origin including North America, Europe, Asia, and Australia. In total, 37 studies were included (29 retrospective studies, 4 cross-sectional studies, and 4 prospective cohort studies) in our meta-analysis: 24 studies for AMI, 11 studies for HF, and 2 studies for both AMI and HF. This included a total of 21 107 886 patients with AMI (2 230 264 of which were in rural regions) and 18 434 270 patients with HF (2 655 469 of which were in rural regions). Rural patients with AMI had similar age (mean age 69.8 ± 5.7; vs. 67.5 ± 5.1) and were more likely to be female (43.2% vs. 38.5%) compared to urban patients. Rural patients with HF had similar age (mean age 77.1 ± 4.4 vs. 76.5 ± 4.2) and were more likely to be female (56.4% vs. 49.5%) compared to urban patients. The range of follow-up for the AMI cohort was 0 days to 24 months, and the range of follow-up for the HF cohort was 0 days to 24 months. Compared with urban patients, rural patients with AMI had higher mortality rate at follow-up [15.5% vs. 13.4%; OR 1.18, 95% confidence interval (CI), 1.13–1.24; I2 = 97%]. Compared with urban patients, rural patients with HF had higher mortality rate at follow-up (12.3% vs. 11.6%; OR 1.11, 95% CI, 1.11–1.12; I2 = 98%).

Conclusion
To our knowledge, this is the first systematic review and meta-analysis assessing mortality differences between rural and urban patients presenting with AMI and HF. We found that patients living in rural areas had an increased risk of mortality when compared to patients in urban areas. Clinical and policy efforts are required to reduce these disparities.

Lay summary
A total of 37 studies were included in our meta-analysis, involving over 39.5 million patients, and found higher mortality rates in rural patients with AMI and HF compared to those in urban areas. Clinical and policy efforts should focus on improving access to care and outcomes to reduce disparities between rural and urban areas.