bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound‐Guided Dry Needling of the Healthy Rat Supraspinatus Tendon Elicits Early Healing Without Causing Permanent Damage
Authors: Riggin Corinne N. , Chen Mengcun , Gordon Joshua A. , Schultz Susan M. , Soslowsky Louis J. , Khoury Viviane 
Published: May 2019

ABSTRACTOveruse‐induced tendinopathy is highly prevalent in the general population. Percutaneous fenestration, or dry needling, techniques have been increasing in popularity, but despite their current use, there are no controlled laboratory studies to provide fundamental support for this practice. The objective of this study was to establish a model for percutaneous needling of the rat supraspinatus tendon using ultrasound guidance and to evaluate the biological response of needling healthy tendon. A total of 44 male Sprague–Dawley rats (477 ± 39 g) were used to evaluate the effect of dry needling on healthy supraspinatus tendon properties. Ten rats were reserved as un‐needled control animals, and the remaining animals underwent either mild or moderate bilateral needling protocols and were sacrificed at 1 or 6 weeks post‐needling (n = 8–10/group). Color Doppler ultrasound imaging was performed to analyze blood flow within the tendon. Histological and immunohistochemical analyses were used to determine cellular, inflammatory, and extracellular matrix properties of the tissue. Finally, quasi‐static tensile mechanical analysis was performed to obtain viscoelastic, structural, and material properties to evaluate the tendon healing outcome. Data were tested for normality, and then two‐way analysis of variance tests were performed followed by post hoc tests for multiple comparisons. Both the mild and moderate needling groups caused a transient healing response at early time points as shown by a statistically significant (p < 0.05) reduction in mechanical properties, and increase in blood flow, inflammation, and production of collagen III and glycosaminoglycans as compared to the control. Furthermore, mild needling properties returned to or exceeded pre‐needling values at the 6‐week time point. Clinical significance: Needling the rat supraspinatus tendon is a feasible technique that causes a transient healing response followed by a return to, or improvement of, normal tendon properties, indicating potential applicability in understanding the effects of current practices utilizing dry needling of tendons in humans. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2035–2042, 2019
Muscle and Joint Function After Anatomic and Reverse Total Shoulder Arthroplasty Using a Modular Shoulder Prosthesis
Authors: Ackland David C. , Wu Wen , Thomas Richard , Patel Minoo , Page Richard , Sangeux Morgan , Richardson Martin 
Published: May 2019

ABSTRACTChanges in joint architecture and muscle loading resulting from total shoulder arthroplasty (TSA) and reverse total shoulder arthroplasty (RSA) are known to influence joint stability and prosthesis survivorship. This study aimed to measure changes in muscle moment arms, muscle lines of action, as well as muscle and joint loading following TSA and RSA using a metal‐backed uncemented modular shoulder prosthesis. Eight cadaveric upper extremities were assessed using a customized testing rig. Abduction, flexion, and axial rotation muscle moment arms were quantified using the tendon‐excursion method, and muscle line‐of‐force directions evaluated radiographically pre‐operatively, and after TSA and revision RSA. Specimen‐specific musculoskeletal models were used to estimate muscle and joint loading pre‐ and post‐operatively. TSA lateralized the glenohumeral joint center by 4.3 ± 3.2 mm, resulting in small but significant increases in middle deltoid force (2.0%BW) and joint compression during flexion (2.1%BW) (p < 0.05). Revision RSA significantly increased the moment arms of the major abductors, flexors, adductors, and extensors, and reduced their peak forces (p < 0.05). The superior inclination of the deltoid significantly increased while the inferior inclination of the rotator cuff muscles decreased (p < 0.05). TSA using an uncemented metal‐backed modular shoulder prosthesis effectively restores native joint function; however, lateralization of the glenoid component should be minimized intra‐operatively to mitigate increased glenohumeral joint loading and polyethylene liner contact stresses. Revision RSA reduces muscle forces required during shoulder function but produces greater superior joint shear force and less joint compression. The findings may help to guide component selection and placement to mitigate joint instability after arthroplasty. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1988–2003, 2019
Typical Shape Differences in the Subtalar Joint Bones Between Subjects with Chronic Ankle Instability and Controls
Authors: Tümer Nazlı , Vuurberg Gwendolyn , Blankevoort Leendert , Kerkhoffs Gino M M. J. , Tuijthof Gabrielle J. M. , Zadpoor Amir A. 
Published: May 2019

ABSTRACTBone shapes, particularly those defining the subtalar joint (STJ), have not received much attention yet as a risk factor for developing chronic ankle instability (CAI) after sustaining a lateral ankle sprain (LAS). This study aimed to compare three‐dimensional (3D) shape variations in the STJ bones within individuals with CAI and healthy controls. 3D statistical shape models (SSMs) of the STJ bones were built to describe the bone shape variations observed within a population consisting of 26 individuals with unilateral CAI and 26 healthy controls. Using the SSMs and analysis of covariance test, age‐ and gender‐adjusted shape variations in the bones were compared within individuals with CAI and healthy controls. The mean age of the CAI patients (14 males and 12 females) and healthy controls (12 males and 14 females) was 29 (standard deviation [SD] = 11) and 36 years (SD = 11), respectively. Tali and calcanei did not significantly vary between ipsilateral CAI and their contralateral ankle. Two shape modes, one for the talus (p = 0.015, variations in the curvature of the talar lateral process and the inclination angle of the talar neck relative to the body) and one for the calcaneus (p = 0.003, variations in the medial and lateral tuberosities, and the contour of the anterior articular surface), described significant shape differences between the CAI patients and healthy controls. The CAI patients generally had flatter talar joint surfaces and a flattened calcaneal ground‐contact surface. These findings suggest that specific bone shapes may increase the risk of developing CAI after sustaining a LAS. © 2019 The Authors. Journal of Orthopaedic Research® Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 37:1892–1902, 2019
S‐(E)‐Elenolide: a new constituent of extra virgin olive oil
Authors: Rigakou Aimilia , Diamantakos Panagiotis , Melliou Eleni , Magiatis Prokopios 
Published: May 2019

AbstractBACKGROUNDExtra virgin olive oil is a food with a recognized health claim in the EU related to its phenolic content. Based on nuclear magnetic resonance (NMR) analysis, we observed for the first time that most high‐phenolic olive oils also contain significant quantities of another potential beneficial ingredient, S‐(E)‐elenolide, which is a non‐phenolic compound related to oleuropein or ligstroside. Elenolide had only been found in olive leaves and fruits as the Z isomer or had been synthesized and had been recognized as an antihypertensive agent.RESULTS(E)‐Elenolide was isolated from olive oil and its structure was elucidated and completely characterized for the first time using 1D and 2D NMR and gas chromatography–mass spectrometry. In addition, we developed a method of quantitative measurement based on qNMR. Investigation of 2120 olive oil samples showed that elenolide was present in the majority of samples, in quantities ranging from 0 to 2821 mg kg−1. Although elenolic acid, which is a hydrated derivative of elenolide, had been reported as an olive oil ingredient, this is the first time that elenolide has proved to be transformed to elenolic acid after reaction with water. Finally, it was found that the quantity of elenolide in olive oil depends on the quantity of water remaining in the olive oil during storage.CONCLUSIONS‐(E)‐Elenolide is a new important substance of olive oil and could be used as marker of high‐quality oils with low water content. © 2019 Society of Chemical Industry
Dissolvable layered double hydroxide as a sorbent in dispersive micro‐solid phase extraction for the determination of acidic quinolones in honey by HPLC
Authors: Di Xin , Wang Xin , Liu Youping , Guo Xingjie , Di Xin 
Published: May 2019

AbstractThis study presents a simple and green dispersive micro‐solid phase extraction method for preconcentration of acidic quinolones from honey prior to high performance liquid chromatography determination. A two‐dimensional nanostructured zinc‐aluminum layered double hydroxide was synthesized and used as the sorbent for dispersive micro‐solid phase extraction. Its different characteristics from conventional sorbents is that it is dissolvable in acidic solution (pH < 4). After the extraction, the analyte elution step was omitted and thus the use of organic solvents was avoided. The key parameters influencing the extraction efficiency such as the amount of sorbent, pH of sample solution, vortex time, type and volume of acidic solution were investigated and optimized. The method exhibited low limits of detection (3.0−5.0 ng/g), good linearity (10−2000 ng/g) with coefficients of determinations higher than 0.9991, acceptable precision (RSD<9.1%) and accuracy (RE<5.8%). The proposed method is fast, efficient, eco‐friendly, and suitable for the determination of acidic quinolones in honey samples.
Which Is the Best Reference Tissue for Strain Elastography in Predicting Malignancy in Thyroid Nodules, the Sternocleidomastoid Muscle or the Thyroid Parenchyma?
Authors: Görgülü Feride Fatma 
Published: May 2019

ObjectivesThis study aimed to compare 2 types of strain ratios (SRs) in thyroid nodules. Two reference points were used: the sternocleidomastoid (SCM) muscle and the thyroid parenchyma.MethodsA total of 101 nodules in 83 patients were prospectively enrolled in the study. For the semiquantitative analysis, 2 types of SRs were used: SR1, the ratio of the SCM muscle strain to the thyroid nodule strain; and SR2, the ratio of the surrounding normal thyroid tissue strain to the thyroid nodule strain. For each nodule, the SR1 and SR2 elastographic values were calculated, and their averages were compared.ResultsEighty‐one (80.2%) of 101 thyroid nodules were benign, and 20 (19.8%) were malignant. In both benign and malignant histopathologic types, the SR1 averages were significantly higher than the SR2 averages (P = .001; P < .001, respectively). Both the SR1 and SR2 values were found to be significantly successful in differentiating benign from malignant histopathologic types (P < .001 for both). The areas under the curve were then compared for the methods, and the difference was found to be statistically significant (P = .046). The diagnostic accuracy of the SR1 was superior to that of the SR2.ConclusionsThe SR1 and SR2 are effective adjunctive diagnostic tools for identifying malignant thyroid nodules. Using the SCM muscle as a reference point instead of thyroid tissue may be a more valuable way to measure SRs.
Predicting Pouch of Douglas Obliteration Using Ultrasound and Laparoscopic Video Sets: An Interobserver and Diagnostic Accuracy Study
Authors: Chiu Le Chi , Leonardi Mathew , Lu Chuan , Mein Brendan , Nadim Batool , Reid Shannon , Ludlow Joanne , Casikar Ishwari , Condous George 
Published: May 2019

ObjectivesTo investigate the diagnostic accuracy and interobserver agreement among sonologists when assessing offline ultrasound (US) video sets of the “sliding sign” and among gynecologic surgeons when assessing corresponding laparoscopic video sets to predict pouch of Douglas (POD) obliteration and to compare the performance of the groups.MethodsA diagnostic and reproducibility study was conducted, including 15 observers in 4 groups: (1) senior sonologists, (2) junior sonologists, (3) general gynecologists, and (4) advanced laparoscopists. The sonologists viewed 25 offline preoperative US video sets of the sliding sign, and the surgeons viewed the corresponding intraoperative laparoscopic videos of the same patients. Each observer was asked to classify POD obliteration in the video sets and was compared to the reference standard POD state determined at real‐time laparoscopy by a single investigator (G.C.). The interobserver correlation and diagnostic accuracy were evaluated among the 15 observers and 4 groups. The Cohen κ coefficient and Fleiss κ coefficient were used for the analysis.ResultsThe overall accuracy, sensitivity, specificity, positive predictive value, and negative predictive value for senior sonologists were 93.3%, 100%, 89.6%, 84.4%, and 100%, respectively; for junior sonologists, 70.0%, 88.9%, 59.4%, 55.2%, and 90.5%; for general gynecologists, 75.2%, 88.1%, 78.1%, 69.8%, and 91.9%; and for advanced laparoscopists, 82.4%, 91.9%, 90.8%, 82.9%, and 95.8%. The overall agreement between senior sonologists was almost perfect (Fleiss κ = 0.876); for junior sonologists and general gynecologists, it was moderate (Fleiss κ = 0.589 and 0.528); and for advanced laparoscopists, it was substantial (Fleiss κ = 0.652).ConclusionsInterobserver agreement was superior among senior sonologists. Prediction of POD obliteration using offline US videos by senior sonologists is comparable to offline assessments of laparoscopic videos by advanced laparoscopists for prediction of POD obliteration.
Guidelines on the surgical management of sleep disorders: A systematic review
Authors: Mandavia Rishi , Mehta Nishchay , Veer Vik 
Published: May 2019

ObjectiveTo facilitate the development of U.K. guidelines for sleep surgery and to guide sleep surgeons to existing guidelines relevant to their practice, we provide a systematic review and quality assessment of all existing guidelines on the surgical management of sleep disorders.MethodsSystematic review using preferred reporting items for systematic reviews and meta‐analyses (PRISMA) recommendations. Medline and Embase databases were searched from inception to April 2018. Publications were included if they described a guideline for the surgical management of sleep disorders. Three assessors used the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument to evaluate included guidelines.ResultsThe systematic search revealed 1,161 publications. Twenty‐two guidelines from eight countries were included. Fourteen focused on adults, five on children, and three on both. The guidelines discussed nasal, tonsillar, palatal, tongue, hyoid, maxillomandibular, tracheal, bariatric, and multilevel surgeries. The mean overall AGREE II quality score of included guidelines was 3.5 (range = 2 to 5.3; maximum possible score = 7).ConclusionThis article provides a summary and quality assessment of all published guidelines on the surgical management of sleep disorders. No U.K. guidelines were identified, and existing guidelines have several shortcomings. This highlights the need for robust U.K. national guidelines on sleep surgery to promote clinical and cost‐effective care in this field. Our findings can be used by stakeholders as a foundation for the development of new guidelines and can be used by sleep surgeons to direct them to existing guidelines relevant to their practice, promoting evidence‐based clinical care. Laryngoscope, 130:1070–1084, 2020
Measuring Flap Oxygen Using Electron Paramagnetic Resonance Oximetry
Authors: Polacco Marc A. , Hou Huagang , Kuppusamy Periannan , Chen Eunice Y. 
Published: May 2019

Objectives/HypothesisTo determine if electron paramagnetic resonance (EPR) oximetry is a viable technology to aid in flap monitoring.Study DesignProspective cohort.MethodsThis was a cohort study assessing accuracy and speed of EPR oximetry in detecting ischemia of a saphenous artery–based flap in a rat model, using transcutaneous oximetry as a control. Measurements were obtained under both resting and ischemic conditions for nine Sprague Dawley rats (18 flaps), for 3 postoperative days following flap elevation.ResultsThe mean partial pressure of oxygen prior to tourniquet application was 66.9 ± 8.9 mm Hg with EPR oximetry and 64.7 ± 5.2 mm Hg with transcutaneous oximetry (P = .45). Mean partial pressures of oxygen during tourniquet application were 8.9 ± 3.2 mm Hg and 8.5 ± 2.9 mm Hg for EPR oximetry and transcutaneous oximetry, respectively (P = .48), and 67.2 ± 6.9 mm Hg and 65.3 ± 6.1 mm Hg after tourniquet release for EPR oximetry and transcutaneous oximetry, respectively (P = .44). The mean ischemia detection time of EPR oximetry was 49 ± 21 seconds.ConclusionsOffering timely, accurate, and noninvasive tissue oxygen measurements, EPR oximetry is a promising adjunct in flap monitoring.Level of EvidenceNA Laryngoscope, 129:E415–E419, 2019
Electrochemical evaluation of the corrosion protectiveness and porosity of vacuum annealed CrAlN and TiAlN cathodic arc physical vapor deposited coatings
Authors: Adesina Akeem Yusuf , Gasem Zuhair M. , Kumar A. Madhan 
Published: May 2019

AbstractThe corrosion behavior of cathodic arc physical vapor deposited CrAlN and TiAlN coatings were examined in 1 M HCl solution before and after vacuum annealing at 700, 800, 900, and 1000 °C. Electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP) methods were used to study the corrosion behavior and porosity of the coatings in comparison with the bare steel substrate (304SS). Structural and mechanical characterization of the coatings were also conducted. It is found that with increasing annealing temperature, the mechanical properties of TiAlN increased due to age hardening caused by spinodal decomposition while the hardness of CrAlN decreased as result of relaxation. Similarly, EIS and PDP results revealed that the as‐deposited and annealed coatings offer higher corrosion resistance as compared to the bare 304SS substrate. The coatings susceptibility to corrosion is reduced after annealing as indicated by the increasing nobility of Ecorr. Both PDP and EIS tests revealed that CrAlN coating annealed at 1000°C exhibited superior corrosion resistance properties. It is found that the reduced current density for CrAlN coating annealed at 1000°C was due to the reduction in the porosity. Annealed TiAlN coating follows similar behavior until an optimum annealing temperature of 800°C. Beyond this temperature, porosity enlargement and an increase in the number of pores subsequent to structural changes deteriorated the corrosion resistance of TiAlN coating.
Cationic Polymerization of (3‐Aminopropyl)‐tris‐furfuryloxysilane Derivatives—a New Strategy for Complex Hybrid Material Synthesis
Authors: Uhlig Daniel , Seifert Andreas , Schreiter Katja , Rüffer Tobias , Lang Heinrich , Thielbeer Frank , Stoll Ragnar , Müller Philipp , Spange Stefan 
Published: May 2019

AbstractThe trifunctional (3‐aminopropyl)‐tris‐furfuryloxysilane monomer (1) is able to undergo both twin polymerization and reaction with electrophilic compounds such as isocyanates. 1 can be readily synthesized from 3‐aminopropyptrimethoxysilane (APTMS) and furfuryl alcohol (FA). The reaction of 1 with three different aromatic isocyanates, namely phenyl isocyanate, diphenylmethane‐4,4′‐diisocyanate (MDI), and a prepolymer consisting of MDI end‐capped polytetramethylene ether glycole (PTMEG), to the corresponding substituted urea derivatives is presented. Three urea derivatives 1‐phenyl‐3‐(3‐tris‐furfuryloxysilyl)propylurea (2), diphenylmethan‐4,4′‐bis[3(tris‐furfuryloxysilyl)propyl]urea (3), bis[3(tris‐furfuryloxysilyl)‐propyl]urea‐capped PTMEG‐MDI‐prepolymer (4) as well as 1 were polymerized to multicomponent organic/inorganic hybrid materials in a one step procedure using methane sulfonic acid as catalyst. The simultaneous formations of poly furfuryl alcohol and polysiloxane networks within the hybrid material are proven by means of solid‐state NMR spectroscopic measurements. The homogeneous distribution of silicon within the solidified hybrid materials is analyzed by scanning electron microscopy, energy dispersive X‐ray spectroscopy, and high‐angle annular dark field‐scanning transmission electron microscopy (HAADF)‐STEM. Homogeneous nanostructured hybrid materials with silicon cluster sizes in the range of 2 nm have been obtained by polymerization of the urea derivatives 2, 3, and 4.
The use of transcranial magnetic stimulation as a treatment for movement disorders: A critical review
Authors: Latorre Anna , Rocchi Lorenzo , Berardelli Alfredo , Bhatia Kailash P. , Rothwell John C. 
Published: May 2019

ABSTRACTBackgroundTranscranial magnetic stimulation is a safe and painless non‐invasive brain stimulation technique that has been largely used in the past 30 years to explore cortical function in healthy participants and, inter alia, the pathophysiology of movement disorders. During the years, its use has evolved from primarily research purposes to treatment of a large variety of neurological and psychiatric diseases. In this article, we illustrate the basic principles on which the therapeutic use of transcranial magnetic stimulation is based and review the clinical trials that have been performed in patients with movement disorders.MethodsA search of the PubMed database for research and review articles was performed on therapeutic applications of transcranial magnetic stimulation in movement disorders. The search included the following conditions: Parkinson's disease, dystonia, Tourette syndrome and other chronic tic disorders, Huntington's disease and choreas, and essential tremor. The results of the studies and possible mechanistic explanations for the relatively minor effects of transcranial magnetic stimulation are discussed. Possible ways to improve the methodology and achieve greater therapeutic efficacy are discussed.ConclusionDespite the promising and robust rationales for the use of transcranial magnetic stimulations as a treatment tool in movement disorders, the results taken as a whole are not as successful as were initially expected. There is encouraging evidence that transcranial magnetic stimulation may improve motor symptoms and depression in Parkinson's disease, but the efficacy in other movement disorders is unclear. Possible improvements in methodology are on the horizon but have yet to be implemented in large clinical studies. © 2019 International Parkinson and Movement Disorder Society © 2019 International Parkinson and Movement Disorder Society
Whole‐brain B1‐mapping using three‐dimensional DREAM
Authors: Ehses Philipp , Brenner Daniel , Stirnberg Rüdiger , Pracht Eberhard D. , Stöcker Tony 
Published: May 2019

PurposeDemonstration of a 3D version of the DREAM sequence (3DREAM) for rapid 3D flip angle and mapping of the human brain.MethodsA rectangular non‐selective STE preparation is followed by a 3D readout with a Cartesian center‐out spiral phase encoding order. This enables parallel imaging acceleration in both phase encoding dimensions as well as early capture of the prepared magnetization.Results mapping of the whole human head is demonstrated on a 7T system at a nominal resolution of 5 mm with and without parallel imaging acceleration. Artifacts caused by the different signal decay of the FID and STE signal during the long imaging train is suppressed by appropriate filtering of the FID image. Remaining blurring can be controlled by adjusting the echo train length and readout flip angle.Conclusions3DREAM provides a whole‐brain flip angle map in a few seconds or individual maps for an 8‐channel array in about a minute.