bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteonecrosis of the Jaws in Patients Receiving Anti-Angiogenic Drugs and Chemotherapeutics: Literature Review and Case Reports
Authors: Mihaylova Z. , Ugrinov R. , Aleksiev E. , Stanimirov P. 
Published: June 2019

Abstract
Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but serious pathology associated with the use of bisphosphonates (BPs) and antiresorptive drugs in patients with bone metastases, multiple myeloma and osteoporosis. Various cases of patients with jaw bone necrosis due to BPs have recently been reported in the literature. Anti-angiogenic drugs are novel anticancer agents prescribed to patients with renal carcinoma, lung carcinoma, soft tissue metastases, etc. Anti-angiogenic drugs target the vascular endothelial growth factor’s (VEGF) signaling pathways via different mechanisms and thus inhibit tumor cell proliferation, neoangiogenesis and tumor growth. Several reports have suggested a higher incidence of MRONJ in patients treated with BPs in combination with anti-angiogenic drugs. However, there is currently no sufficient data in the literature about the risk of ONJ in patients taking anti-angiogenic drugs or cancer chemotherapy alone. We present two clinical cases of osteonecrosis of the jaw in patients treated with chemotherapy, but no history of BPs. In the first case the necrosis is related to the anti-angiogenic agent sunitinib in a patient with lung metastases and in the second case- to complex chemotherapy in a patient with acute myeloid leukemia. We recommend conservative treatment with antibiotics in both cases, together with antiseptics and surgical removal of the necrotic bone following total demarcation of the sequesters.
The Late Gothic Portal in Trebišov Pauline Order Church, Architecture and Geometry
Authors: Grúňová Zuzana , Borošová Michalcová Miloslava , Vesztróczy Éva 
Published: June 2019

Abstract
Gothic architecture is one of the oldest surviving architecture in Slovakia. The Church of Pauline Order in Trebišov has many building phases; its entrance stone portal belongs to the later phase dated about the second half of the 15th century. Paper focuses on an architectural features and geometry of this portal. Portal has clearly a geometrical construction that is compared to another late gothic portal from church in Handlová. Conclusion suggests, that ratio of the entire portal dimensions is close to 4 : 3, proportions of jamb and opening widths are 1 : 4 : 1 part of the overall portal width and there highly probably existed some simple method of determining position of pointed arch arches.
Valorization of Crushed Glass as a Potential Replacement for Sand in Cement Stabilized Fly Ash Bricks
Authors: Saraswathy R. , James Jijo , Pandian P. Kasinatha , Sriram G. , Sundar J. K. , Kumar G. Swarna , Kumar A. Sathish 
Published: June 2019

Abstract
The present study involved the utilization of crushed glass as an auxiliary additive in the manufacture of cement stabilized fly ash (CSF) bricks. The bricks were made with 1:1 proportion of fly ash and sand stabilized with 20 % cement. Crushed glass was used as replacement for the fine aggregate in increments of 10 % up to 40 % wherein the sand was completely replaced with crushed glass. The various mix proportions were then moulded into bricks with the addition of water by hand moulding method of forming the bricks and sun dried followed by sprinkle curing over a period of 21 days. The bricks were then subjected to compressive strength, water absorption and efflorescence tests to gauge its performance. The investigation revealed that the addition of crushed glass to the brick mix resulted in an increase in strength of the bricks, however, the maximum strength achieved could not achieve the strength of the control specimen. But the strength was higher than the minimum strength recommended by Bureau of Indian Standards (BIS) for stabilized blocks as well as burnt bricks. It also reduced the water absorption marginally while no efflorescence was seen in any of the combinations. A cost comparison revealed that the optimal combination with crushed glass was able reduce the cost of the brick by 20 %.
Comparison of 2D Grid Simulations for Flow Past Cylinder at High Reynolds Numbers
Authors: Lausová Lenka , Kološ Ivan , Michalcová Vladimíra 
Published: June 2019

Abstract
The paper focuses on the verification of the suitability of the SST k - ω model on the flow past a circular cylinder in 2D for a high Reynolds number. The study compares the results of drag and lifts coefficients with respect to different types of meshes and time steps. The mean velocity field in the wake region behind the cylinder is evaluated and compared to experimental data available from literature. The numerical simulations are solved using CFD codes in the ANSYS Fluent software and use the finite volume method.
Homophily in co-autorship networks
Authors: Stoica Adelina-Alexandra 
Published: June 2019

Abstract
The main purpose of this paper is to measure the impact that homophily, structural characteristics of the networks, number of citations of the alters and their Hirsch score have on the number of citations of an ego. I have chosen co-authorship networks as a subject of research because they have a great influence on knowledge and on the diffusion of ideas. The studied populations are represented by full-time academics affiliated to sociology departments in Romania, Poland and Slovenia. Ego-network analysis was used as research design. The data was analyzed using linear hierarchical regression. For all three populations the average number of citations of the alter has a considerable positive impact on the number of citations of the ego. Conversely, the Hirsch score of the alter has a negative impact on the number of citations of the ego. The data analyzed in this article claims that the assumptions about the positive impact of alter citations, network size and the betweenness score on the number of the authors citations are supported empirically.
The impact of transnational co-authorship on the scientific quality of academic researchers-Case Studies: Slovenia, Poland and Romania
Authors: Mihăilă Bianca Elena 
Published: June 2019

Abstract
The aim of this article is to contribute to the discussion about whether the scientific impact of an academic researcher (measured through bibliometrics indices as Hirsch score, citation scores or quantitative data about publications) can be accounted for by the presence of co-authors and the characteristics of the personal networks they are embedded in. With my study, I intend to demonstrate that there is statistical evidence between international co-authorship, measured through the number and the characteristics of international co-authors and the scientific impact of the researcher. Recent studies using bibliometrics and scientometrics approach shows that papers published with international co-authors may result in a higher citation rate than the ones written in a purely national manner (with national co-authors) (Glanzel & Schubert, 2001; Schmoch & Schubert, 2008). In the literature that addresses these issues, the main focus is put on international co-authorship, but my opinion is that the concept has undergone a series of methodological changes. I address these changes as a trend towards a transnational perspective. I explored the personal networks of university researchers, from three academic communities in the field of sociology. I analyzed the data using hierarchical regression models. This article is based on secondary data analysis starting from the data Hâncean used in 2016 (Hâncean & Perc, 2016). The data provided attribute and relational data for the focal nodes and their corresponding alters from Web of Science platform. Given the theoretical framework proposed by previous research (Adams, 2012; Hâncean & Perc, 2014; Glanzel & Schubert, 2004), I expected the scientific impact of an author to be positively influenced by the impact of the personal network he is embedded in. After running the analysis, the presence of transnational co-authors has a moderate impact on the citation distribution, especially for the Romania case. The biggest impact on the citation distribution, for all academic communities I included in the analysis, are the number of publications and the average number of co-authors’ citations. The description and the exploration of the data in all three communities of academic sociologists (Romania, Poland and Slovenia) will be used later in order to show new ways in which knowledge is transferred through the lens of a transnational perspective.
The Peculiarities of Remodelling Muscle Tissue of Rats Under the Vibration Influence
Authors: Kostyshyn Nazar M. , Kostyshyn Liybov P. , Servetnyk Marta I. , Grzegotsky Mechyslav R. 
Published: June 2019

Abstract
Study of the influence of vibration oscillations of different frequency, amplitude and vibration acceleration on the structural and functional state and mechanisms of muscle tissue remodelling. An experimental study was conducted on sexually mature male rats. The rats of the four experimental groups were subjected to vertical vibration oscillations of 15, 25, 50 and 75 Hz, respectively. It has been established that pathological changes in muscle tissue in the form of different variants of damage and remodelling tend to increase, which correlates with the frequency of vibration, amplitude and vibration acceleration level, as in the 2nd group, where the maximum permissible vibration levels did not exceed the established allowable norms, and in other groups of animals, where the permissible levels of total vibration were exceeded. By increasing vibration acceleration for more than 1.25 m/s2 (0.13 g, frequency more than 25 Hz and amplitude of 2 mm), severe damages are observed in the form of alterative changes of muscle fibres with the disappearance of transverse strain, homogenization of sarcoplasm, fragmentation with dissociation fibres on separate beams, partial and subtotal myocytolysis, and necrosis of separate fibres. Inflammation is rapidly increasing with the increase in the frequency of vibration and the level of vibration acceleration for more than 5.0 m/s2 (0.51 g).
Remission of Late-Onset Post-Liver Transplantation Non-Hodgkin Lymphoma
Authors: Stardelova Kalina Grivcheva , Stojanovik Aleksandar , Jovanovska Rozalinda Popova , Stavrik Sonja , Dimitrova Magdalena , Kostova Neda Milevska , Serafimoski Vladimir 
Published: June 2019

Abstract
We describe the clinical course of a patient who developed high-grade lymphoma during immunosuppression treatment with cyclosporine A, following liver transplantation. After anti-neoplastic polychemotherapy treatment, the remission of lymphoma was confirmed and maintained for over four years.
The patient, a 27 year old female had liver transplantation at the age of 17, due to acute liver failure, caused by non-diagnosed Wilson disease. Nearly seven years post-transplantation, the patient was diagnosed with non-Hodgkin B-cell lymphoma (NHBCL), potentially induced by Cephalosporin A therapy. After the treatment with rituximab and CHOP therapy (r-CHOP protocol), remission was determined using computer tomography. Remission is maintained to date.
A review of reported cases of post-transplant lymphoproliferative disorders (PTLDs) in liver transplanted (LT) patients showed that the onset of PTLDs is the highest in the first year after transplantation. In addition, remission rates of NHBCL in LT patients are not much elaborated in the literature. It is our opinion that the presented case is rare, both from the aspect of timeline of occurrence of the PTLD and the achieved remission, using r-CHOP protocol.
Importance of 6-Thioguanine Nucleotide Metabolite Monitoring in Inflammatory Bowel Disease Patients Treated with Azathioprine
Authors: Pavlovska Kristina , Petrushevska Marija , Gjorgjievska Kalina , Zendelovska Dragica , Ribarska Jasmina Tonic , Kikerkov Igor , Gjatovska Liljana Labachevska , Atanasovska Emilija 
Published: June 2019

Abstract
The active metabolite of azathioprine, 6-thioguanine nucleotide (6-TGN) is the main component responsible for the immunosuppressive effect in treatment of inflammatory bowel disease (IBD).
The aim of this study was to assess the correlation between the concentration of 6-thioguanine nucleotide and disease activity, azathioprine-related adverse effects and time duration of treatment in patients with inflammatory bowel disease.
Thirty-four patients were included in this study. Type of disease, gender, time duration of therapy and adverse effects were recorded. Metabolite concentration was determined by high performance liquid chromatography.
Twenty-one percent of patients have experienced an adverse effect, with leucocytopenia most commonly occurring (42.9%). More adverse effects were registered when patients were treated with azathioprine in a period of less than 3 months in comparison to the group of patients that have been under therapy between 3-12 months and more than 12 months (p˂0.05). Most of the patients that presented any adverse effect had high 6-TGN concentration (>450 pmol/8x108 Er). The mean value of 6-TGN metabolite concentration in IBD patients treated with azathioprine was 437.46 pmol/8x108 Er ± 198.82 pmol/8x108. The time duration of azathioprine treatment did not have any significant impact on the achieved 6-TGN concentration (p>0.05).Twenty patients (58.9%) had achieved remission after therapy initiation with azathioprine.
More alertness is recommended to clinicians towards patients in the first 3 months of the therapy. Our study demonstrated that higher 6-TGN concentration is associated with azathioprine toxicity.
Posterior Reversible Encephalopathy Syndrome (PRES) in Children Undergoing Allogeneic Stem Cell Transplantation
Authors: Veljanovska Aleksandra Pivkova , Stojanoski Zlate , Chadievski Lazar , Stavridis Irina Panovska , Trajkova Sanja , Cevreska Lidija , Georgievski Borche 
Published: June 2019

Abstract
Posterior reversible encephalopathy syndrome (PRES) is one of the most serious complication after allogeneic stem cell transplantation in paediatric setting. It is most commonly reported as adverse event of immunosuppressive strategies during transplantation. We present a case of a 7 years old girl with myelodysplastic syndrome (MDS) treated with allogeneic stem cell transplantation (ASCT) at our department. Diagnosis of PRES was confirmed by imaging techniques during the first month after transplant and it was very likely connected with cyclosporine neurotoxicity. The aim of this article is to present our first experience in diagnosing and treating PRES in paediatric stem cell transplantation. Our experience showed that PRES is one of the reasons for higher transplant related mortality in children. Early prediction of factors contributing to PRES and closely monitoring of patient’s vital signs, especially blood pressure, neurological status and vision are the main contributors for challenging the patient with another immunosuppressive agent that has less neurological toxicity. Still studies have to be initiated to confirm the influence of PRES on transplant outcome.
Preliminary geophysical investigation for road construction using integrated methods
Authors: Amosun Joel Olayide , Olayanju Gbenga Moses , Sanuade Oluseun Adetola , Fagbemigun Tokunbo 
Published: June 2019

Abstract
Integrated geophysical methods have been used to investigate the competency of the subsoil. The geophysical surveys conducted involve very low-frequency electromagnetic (VLF-EM) and electrical resistivity (ER) methods (dipole-dipole). ABEM Wadi and Ohmega resistivity meter were used to acquire VLF-EM and ER data, respectively, along two traverses. Station interval of 5 m was used for the VLF-EM survey, while inter-electrode spacing for dipole–dipole was 10 m; the inter-dipole expansion factor (n) ranged from 1 to 5. KHFFILT software was used to generate VLF-EM profiles and pseudosection, while DIPRO software was used for ER. Results from the ER method revealed the pattern of resistivity variations within the study area. The low resistivity values (11–25 Ohm-m) observed at the southern part of the study area could be attributed to changes in clay contents and degree of weathering in the subsurface. The results from the VLF-EM investigation revealed the presence of near-surface linear geologic structures of varying lengths, depths and attitudes, which suggest probable conductive zones that are inimical to the foundation of the road subgrade.
Suitability Assessment of Two Types of Heat Exchangers for High Temperature, Naturally Circulating Helium Cooling Loop
Authors: Dzianik František , Gužela Štefan , Puškášová Eva 
Published: June 2019

Abstract
The paper presents a comparison of the process properties of two types of the heat exchangers designed for the heat removal from a high temperature helium cooling loop with steady natural circulation of helium. The first considered heat exchanger is a shell and tube heat exchanger with U-tubes and the other one is a helical coil heat exchanger. Using the thermal and hydrodynamic process calculations, the thermal performance of the two alternative heat exchangers are determined, as well as the pressure drops of flowing fluids in their workspaces. The calculations have been done for several defined operating conditions of two considered types of heat exchangers. The operating conditions of heat exchangers correspond to the certain helium flow rates.
Geometrically Similar Rectangular Passive Micromixers and the Scaling Validity on Mixing Efficiency and Pressure Drops
Authors: Naresh Veldurthi , Bodas D. , Sunil Chandel , Tejashree Bhave 
Published: June 2019

Abstract
In the present work, two geometrically similar passive geometries with dumbbell shape were designed to perturb the dominating viscous forces in the low Reynolds number (Re) flows of the fluids. The geometries were designated as PDM-I and PDM-II, in which all the linear dimensions were related by a constant scale factor of two. Mixing efficiencies and pressure drops of the species at various Reynolds number (Re) were calculated to estimate the scaling effect validations. Finally, the geometrically similar PDM geometries were fabricated in Polydimethylsiloxane (PDMS) polymer to evaluate the scaling effect on the mixing efficiencies of the dyes and validated with the simulation results of species mixing.
The Assessment of the Residual Stresses Influence on Generation of the Infringement in Shape-Complex Supporting Members
Authors: Pástor Miroslav , Čarák Peter , Gömöry Imrich 
Published: June 2019

Abstract
The aim of the paper is to assess the effect of residual stresses on the damage of the slide bearer. To quantify the residual stresses, the drilling method using SINT MTS 3000 drilling machine was chosen. The tensometric rosette application areas were determined based on the analysis of the results obtained by numerical modeling using the finite element method. Experimental measurement was performed on one unused slide bearer and on the other one, which during its present operation had completed about 9.106cycles. At the end of the paper, the analysis of the measured residual stress values in chosen locations is presented.
The Calculation of the Contact Force and the Contact Width of Shaft Seals
Authors: Šlesar Peter , Jančo Roland 
Published: June 2019

Abstract
The aim of the article is to point out the sealing efficiency of the two-language seal of the water pump bearing when radially deflecting the shaft within radial clearance. In order to obtain a radial displacement of the shaft at a location under a two-language seal, dynamic bearing simulation was performed using the MSC Adams program. The largest radial deviation of the shaft was applied in final seal analysis where the contact pressure changes on the individual tongues of the seal were recorded.
Numerical Simulation of Heat Transfer Behavior of Dissimilar AA5052-AA6061 Plates in Fiction Stir Welding: An Experimental Validation
Authors: Vishwanath M. M. , Lakshamanaswamy N. , Ramesh G. K. 
Published: June 2019

Abstract
Fiction Stir welding (FSW) a unique type of metal joining process in solid state, where the heat generation takes place due to the friction action between the rotating tool and the work piece. It is generally used to join all series of Aluminum alloys with good strength and other metallic alloys finds difficult to weld through regular fusion welding techniques. The metal joining takes place in the solid state as the metal to be welded reaches about 80% to 90% of its melting temperature. The joining of metals in friction stir welding does not require any filler metals all classes of Aluminium alloys can be joined and in some desirable cases dissimilar metal compositions and Aluminiun metals composites can be joined satisfactorily. Joining of dissimilar metals has become a trend in the industries like aerospace, automotive chemical etc. as the helps in reducing the cost incurred by eliminating the costly materials. In the present study an experimental investigations are made to study the heat transfer behavior by determining the temperature distribution in AA5052-AA6061 plates during the Friction Stir welding. A three dimensional transient analysis is made by using ANSYS finite element analysis software. Thermocouples are placed at the suitable locations and the same point the temperature readings were taken from the simulation results. The experimental data is compared with the numerically simulated results. The numerical simulations results obtained are in better agreement with the experimental data obtained.
Research of Dependence of the Damage Area on Tow Width on Filament-Wound Composite Tubes
Authors: Bobrowska Marcelina , Barcikowski Michał , Rybczyński Radosław 
Published: June 2019

Abstract
This paper explores the effect of tow width on the damage area produced by high velocity impacts on glass fiber/epoxy composite structures made by filament winding. The subject of the research were a four-layered composite tubes that have been designed using matrix method. The method was used to select mosaic patterns with different rest of the winding stroke and number of interlaces, which are places of stress concentration and which affect the strength of the composite. The narrowest (5 mm) and the widest (17 mm) tow width available was chosen. Composite filament-wound structures were subjected to a high velocity impact by a 2.0 g spherical hardened steel impactor propelled to a velocity of 140 ÷ 170 m/s using a gas gun. It was observed that dependence of the damage area on tow width on filament-wound composite tubes is possible.
Process of Preparing and Laying Carbon Prepregs
Authors: Sokołowski Michał 
Published: June 2019

Abstract
This article contains information on the technological process involved in the production of a composite structure with carbon-epoxy prepregs including critical parameters of the process. The information in the publication shows respectively:
1. Using composite components for constructing the airframe,
2. ways of storing and preserving carbon prepregs on a matrix of thermosetting resins,
3. specific types of varying weave fabrics used in the prepregs,
4. way of preparing material for the process,
5. cutting tools,
6. preparing swage,
7. list of the most popular materials, their characteristics, pros and cons of their applications,
8. issues related to types of release agent,
9. parameters of selecting release agents in the process of manufacturing structures with carbon prepregs,
10. process of laying plies in a layered structure,
11. defects which result from improper material laying in swage,
12. preparing the structure for heating and technical parameters of the process.