bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review on inverse analysis models in steel material design
Authors: Adachi Yoshitaka , Chen Ta‐Te , Sun Fei , Maruyama Daichi , Sawai Kengo , Fukatsu Yoshihito , Wang Zhi‐Lei 
Published: December 2024

AbstractThis paper reviews various inverse analysis models used in steel material design, with a focus on integrating process, microstructure, and properties through advanced machine learning techniques. The study underscores the importance of establishing comprehensive models that effectively link these elements for enhanced materials engineering. Key models discussed include the convolutional neural network–artificial neural network‐coupled model, which employs convolutional neural networks for feature extraction; the Bayesian‐optimized generative adversarial network–conditional generative adversarial network model, which generates diverse virtual microstructures; the multi‐objective optimization model, which concentrates on process–property relationships; and the microstructure–process parallelization model, which correlates microstructural features with process conditions. Each model is assessed for its strengths and limitations, influencing its practical applicability in material design. The paper concludes by advocating for continued improvements in model accuracy and versatility, with the ultimate goal of enhancing steel properties and expanding the scope of data‐driven material development.
Examining the consequences of angling tournament culling practices on Largemouth Bass
Authors: Kamara Shasta R. , Hay Allison A. , Oller Reagan E. , Suski Cory D. 
Published: December 2024

Abstract

Objective
Largemouth Bass Micropterus nigricans are targeted in competitive angling tournaments. Cull tags are a common tournament practice intended to assist anglers in quickly identifying fish by size for “high grading.” Currently, the impacts of cull tags on fish held in typical tournament conditions have not been evaluated thoroughly. This study aimed to quantify the extent and magnitude of injury, reflex impairment, and mortality for Largemouth Bass due to cull tags commonly used in live-release angling tournaments.

Methods
Largemouth Bass were collected via electrofishing, assessed for preexisting injuries, and then outfitted with one of several commercially available cull tags before being placed in a live-well simulation for 6 h. After live-well holding, fish were assessed for reflex action mortality predictors and injury and were then placed in a net-pen for 3 days to assess latent mortality. Reflex impairment was assessed again prior to release.

Result
Tag site injury scores increased after live-well confinement, with stringer-style tags having the highest increase in injury score. Reflexes remained unimpaired after live-well holding and after 3 days of net-pen confinement. No mortalities were observed 3 days after the tournament simulation, indicating that reflexes and mortality are unimpaired by cull tags.

Conclusion
Although our sample sizes were limited (≤10 fish per treatment), stringer-style cull tags appear to cause increased injury rates after simulated tournament live-well holding. Taking a precautionary approach with stringer-style cull tags may help reduce injuries in Largemouth Bass during tournament holding.
Microhabitat conditions and habitat configuration influence juvenile salmonid use of off-channel features in the Cedar River, Washington
Authors: David Aaron T. , Stiling Rebekah R. 
Published: December 2024

Abstract

Objective
Off-channel habitats are crucial for freshwater rearing of juvenile Pacific salmon Oncorhynchus spp., but many of these river floodplain habitats have been lost to human development. While there is a clear need to restore and reconnect off-channel habitats to help recover imperiled salmonid populations, uncertainty exists regarding which characteristics to prioritize when constructing off-channel habitats to maximize the salmonid rearing capacity of these features. To address this uncertainty, we quantified the relative influence of microhabitat conditions and habitat configuration on juvenile salmonid densities within off-channel features of the Cedar River (Washington State).

Methods
We measured microhabitat conditions (water velocity, water depth, cover, and large wood density), habitat configuration (habitat type, distance from the main-stem river, and feature width), and salmonid densities at randomly selected sample units within side channels and backwaters.

Result
Water velocity and depth were strongly associated with subyearling Chinook Salmon O. tshawytscha, subyearling Coho Salmon O. kisutch, and yearling Coho Salmon densities, although the relationships varied among the species–age cohorts and some relationships changed during the spring sampling season. Cover and wood density were also associated with salmonid densities, but the relationships were weaker than for velocity and depth. Habitat configuration was associated with salmonid densities as well, although the relationships varied among the species–age cohorts and between habitat types. For example, within backwaters, subyearling Chinook Salmon densities were highest close to the main-stem river but yearling Coho Salmon densities were highest far from the main stem. Additionally, subyearling Chinook Salmon and Coho Salmon densities were highest within intermediate-width side channels, while yearling Coho Salmon densities exhibited a more complex response to side channel width.

Conclusion
Our results indicate that both microhabitat conditions and spatial configuration influence juvenile salmonid densities within off-channel habitats. These results also suggest that restoration practitioners should carefully weigh trade-offs among design alternatives because different habitat configurations will differentially benefit certain species or life stages.
Hybrid Silica‐Coated Nanomaterials: Pioneering Breakthroughs in Biomedical Technology
Authors: Liao Wei , Elkalla Eslam , Khizar Sumera , Dossary Amal A. A. , Zine Nadia , Errachid Abdelhamid , Elaissari Abdelhamid 
Published: December 2024

ABSTRACTThe field of biomedicine has extensively studied silica‐coated organic/inorganic nanoparticles due to their remarkable properties, such as biocompatibility, chemical stability, ease of functionalization, and thermal stability. Silica has been utilized to coat or encapsulate organic/inorganic nanoparticles, providing protection against aggregation and acid leaching while improving cytocompatibility. This review provides an overview of the manufacturing methods for silica nanoparticles, with a specific focus on surface strategies for core template nanomaterials (both hard and soft templates). These strategies involve the use of chemicals or biomolecules to guide nucleation and growth of silica at the interface of two phases. Furthermore, recent advancements in silica‐coated nanoparticles are discussed, emphasizing their applications in various areas such as bioimaging, drug delivery, biosensors, phototherapy, and hyperthermia.
CRISPR–Cas9 screening identifies the role of FER as a tumor suppressor
Authors: Wang Jiaqi , Yang Ran , Wang Fengsheng , Zhang Junlei , Dong Yutong , Wang Jiangjun , Yu Meng , Xu Yixiao , Liu Lianlian , Cheng Yuda , Zhang Chen , Yang Yi , Yang Wubin , Wang Jiali , Chen Guangxing , Huang Yi , Tian Yanping , Jian Rui , Ni Bing , Wu Wei , Ruan Yan 
Published: December 2024

AbstractIt is important to systematically identify tumor suppressor genes (TSGs) to improve our understanding of tumorigenesis and develop strategies for early diagnosis and mitigating disease progression. In the present study, we used an in vivo genome‐wide clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR‐associated protein 9 (Cas9) screen and identified FPS/FES‐related (FER) as a TSG. Single‐cell RNA sequencing (scRNA‐seq) revealed that normal cells with low FER expression exhibited elevated malignant transformation potential and stemness properties. FER knockout promoted the tumorigenic transformation, characterized by high colony‐forming efficiency and suspension growth ability, acquired tumorigenicity in vivo, increased metabolic activity, dedifferentiation properties, and immune evasion. Moreover, analysis revealed that low FER expression tumors share molecular phenotypes with FER knockout cells, suggesting the consistent role of FER in tumor initiation and progression. Taken together, our findings not only provide insights into the essential role of FER as a tumor suppressor in tumor initiation and progression but also highlight its potential as a target for future clinical diagnosis. © 2024 The Pathological Society of Great Britain and Ireland.
Factors Influencing School‐Based Mental Health Program Selection: Insights From Educational Stakeholders
Authors: Day Elizabeth , Steinka‐Fry Katarzyna , Shimmel Lisa , Grant Sean , Tanner‐Smith Emily E. 
Published: December 2024

ABSTRACTSchool mental health programs are an important component of the national response to the current student mental health crisis. However, evidence‐based programs often face numerous barriers to their selection, scale‐up, and sustainability in real‐world settings. In this study, we interviewed 15 educational stakeholders to examine what influences their selection of school‐based mental health programs. Interviews focused on factors influencing the selection and sustainability of mental health programs in schools. We coded transcribed interview data using a hybrid, iterative process, and generated themes from these codes. We identified five categories of themes related to key decision‐making criteria: program fit with student and school needs, evidence of program effectiveness, stakeholder buy‐in, logistical considerations for staff delivering programs, and cost and resource requirements. Findings have implications for researchers who wish to improve dissemination strategies for school‐based mental health prevention programs and for policymakers who wish to shape funding priorities to support greater diversity in program availability. Findings are also useful to practitioners who may use these insights to reflect on their own program selection practices or may see their own experiences reflected and normalized through the lens of the key themes presented here.
Evaluating Blood–Brain Barrier Permeability, Cytotoxicity, and Activity of Potential Acetylcholinesterase Inhibitors: In Vitro and In Silico Study
Authors: Maboko L. M. , Theron A. , Panayides J.‐L. , Cordier W. , Fisher D. , Steenkamp V. 
Published: December 2024

ABSTRACTAcetylcholinesterase inhibitors (AChEIs) remain the first‐line treatment for Alzheimer's disease. However, these drugs are largely symptomatic and often associated with adverse effects. This study aimed to evaluate novel pharmacophores for their in vitro AChEI activity, blood–brain barrier (BBB) permeability, and cytotoxic potential, hypothesizing that a combination of AChEIs could enhance symptom management while minimizing toxicity. A library of 1453 synthetic pharmacophores was assessed using in vitro and in silico methods to determine their feasibility as an inhibitor of the AChE enzyme. An in‐house miniaturized Ellman's assay determined acellular AChEI activities, while pharmacokinetic properties were evaluated using the SwissADME web tool. The combinational effects of in silico BBB‐permeable pharmacophores and donepezil were examined using a checkerboard AChEI assay. Cytotoxicity of active compounds and their synergistic combinations was assessed in SH‐SY5Y neuroblastoma and bEnd.5 cells using the sulforhodamine B assay. Cellular AChEI activity of active in silico BBB‐permeable predicted compounds was determined using an SH‐SY5Y AChE‐based assay. An in vitro BBB model was used to assess the effect of compounds on the integrity of the bEnd.5 monolayer. Out of the screened compounds, 12 demonstrated 60% AChEI activity at 5 μM, with compound A51 showing the lowest IC50 (0.20 μM). Five compounds were identified as BBB‐permeable, with the donepezil‐C53 combination at ¼IC50 exhibiting the strongest synergy (CI = 0.82). Compounds A136 and C129, either alone or with donepezil, showed cytotoxicity. Notably, compound C53, both alone and in combination with donepezil, demonstrated high AChEI activity and promising BBB permeability, warranting further investigation.
Mechanical, Antimicrobial and Morphological Properties of Biodegradable Trays Based on Cassava Starch and Agroindustrial Processing Residues
Authors: Vieira Agdylannah Felix , Pereira Tálysson Raphael Rodrigues , da Silva Luís Paulo Firmino Romão , Rodrigues Thais Jaciane Araujo , de Almeida Renata Duarte , Santos Newton Carlos , da Costa Maria Eduarda Martins Duarte , de Araújo Gilmar Trindade , Rocha Ana Paula Trindade 
Published: December 2024

ABSTRACTThis study investigated the development of biodegradable composites using agroindustrial residues, such as potato peels and mango integument, processed into flours (PPF and MIF), and determined their nutritional composition, total phenolic content and total tannins. The soluble and insoluble lignin content was quantified in the MIF, which exhibited a high crude fibre content (76.55%) and insoluble lignin (20.86%). Scanning electron microscopy (SEM) examined the morphology of particles and final composites, while the antimicrobial activity of MIF and potato peel extract (PPE) was tested against Staphylococcus aureus. The biodegradability of the composites was assessed in soil, comparing them to commercial EPS. In a factorial design (23), the influence of PPE (1.84–3.68 g), MIF (10–20 g) and drying temperature (55°C–65°C) was investigated regarding the mechanical strength, elongation, antimicrobial activity and physical properties of the composites. Optimal conditions for producing composites with higher strength (1.304 MPa), elongation (0.951%) and antimicrobial activity (30.036‐mm halos) included 3.68 g of PPE, 10 g of MIF and drying at 65°C. However, the interaction between MIF and temperature negatively impacted the results. Biodegradability showed a steady mass loss after 60 days. It is concluded that the use of PPE and MIF offers a sustainable alternative to conventional petroleum‐based packaging, with appropriate production conditions essential to optimize composite properties, reinforcing the potential of the food industry to adopt environmentally friendly materials.
Hybrid Modeling for In Situ Artificial Fish Spawning Ground Stabilization
Authors: Lupinski Kim‐Jehanne , Brousse Guillaume , Maurin Raphaël , Sagnes Pierre , Courret Dominique , Cordier Florian , Lacaze Laurent , Jodeau Magali 
Published: December 2024

ABSTRACTErosion generally reduces the resilience of replenished gravel in rivers. As a result, structures are sometimes added to modify the upstream flow and stabilize artificial spawning grounds. In particular, rows of boulders can be placed around the replenishment area to limit the transport of replenished gravel during flood events. This study aims to optimize the arrangement of these rows, based on field experiments as well as physical and numerical models. A combined hydro‐sedimentary numerical model is calibrated and validated by comparing simulated and measured morphological evolutions in nine laboratory experiments. The results show that boulders positioned downstream of the replenishment slow down the flow above the replenishment, decreasing shear stress over the gravel. The stabilization efficiency depends on both the positioning of the boulders and the arrangement of the replenished surface. To achieve sustainable spawning, prospective scenarios using the numerical model highlight the need to limit the width of the replenishment area. Experiments demonstrated that when the replenishment area spans the entire width flume, the erosion rate is significantly higher compared to a narrower replenishment area placed close to the edges. This effect is attributed to increased flow velocities in the center of the channel, leading to increased shear stress and gravel erosion.
BaS3:Sb2S3:GdS2 Longitudinal Rods: Single‐Source Precursor Synthesis, Characterization, and Electrochemical Applications for Supercapacitance and Catalysis
Authors: Ahmad Khuram Shahzad , Jaffri Shaan Bibi , Al‐Hawadi Jehad S. , Makawana Bhumikaben , Gupta Ram K. , Ashraf Ghulam Abbas , Bahajjaj Aboud Ahmed Awadh 
Published: December 2024

AbstractThis study investigates a unique and energy‐efficient BaS3:Sb2S3:GdS2 nanocomposite chalcogenide system that was made using a single source dithiocarbamate precursor route. The produced dithiocarbamate metallic sulfide has an average crystallite size of 17.38 nm and a small band gap of 3.76 eV. An examination of functional groups revealed the existence of several linkages, including the metal sulfide bond. Morphologically, BaS3:Sb2S3:GdS2 appeared as elongated rods showing greater surface area for electrochemical activity. By constructing a nickel foam electrode and covering it with a slurry of BaS3:Sb2S3:GdS2, the electrochemical charge‐storing behavior of BaS3:Sb2S3:GdS2 was assessed. Prepared electrode exhibited auspicious electrical charge storage capacities with a specific capacitance reaching upto 633.32 F g−1. These findings suggest that there is a significant amount of potential for energy storage in the electrode. This electrode also exhibited a reduced series resistance of (Rs) = 0.31 Ω according to the impedance experiments, and a specific power density of 9109.16 W kg−1. In terms of electrocatalysis, the electrode produced oxygen production overpotential and corresponding Tafel slope of 334 mV and 366 mV dec−1, whereas the hydrogen production overpotential and Tafel slope were 229 mV and 175 mV dec−1, correspondingly.
Crystal Structure, Spectroscopic Analysis, and Nonlinear Optical Properties of Terphenyl‐Based Compound for Optoelectronic Applications
Authors: Arunkumar Dandavathi , Swamy Shashi Kumar Kumara , Bi Sheng Ooi , Ching Kheng Quah , Gummagol Neelamma B. , Dsa Vinitha , Samshuddin Seranthimata 
Published: December 2024

AbstractMulti‐aryl compounds, with conjugated backbones having electron donor and acceptor groups, are widely recognized for their significant nonlinearity. In this context, a new terphenyl compound, ethyl‐4″‐chloro‐5′‐hydroxy‐[1,1′:3′,1″‐terphenyl]‐4′‐carboxylate (EHCMT), has been synthesized for potential use as an optoelectronic material. Single crystal X‐ray diffraction (XRD) analysis of EHCMT revealed a triclinic system with the centrosymmetric space group , providing most accurate description for its crystal structure. The structure of compound was further elucidated through FTIR, NMR (1H, 13C & 2D‐HSQC), and UV–Visible spectroscopic techniques. Hirshfeld surface analysis was employed to examine the magnitude and significance of individual intermolecular interactions in the crystalline arrangement. The third‐order nonlinear optical (NLO) properties were investigated using the Z‐scan technique in a solution phase at 532 nm. The study revealed significant results, namely, nonlinear refraction value of −1.165 × 10−9 cm2 W−1, nonlinear absorption coefficient value of 13.4 × 10−5 cm W−1, and third‐order nonlinear susceptibility value of 0.50 × 10−7 esu. The structural parameters of experimental results were validated by comparing the same with quantum chemical calculations using hybrid functional, namely, Hartree–Fock ‐ Density functional theory (HF–DFT).
Tailoring Photoluminescence Properties of Ternary Zn‐doped Cu─In─Se Quantum Dots via Surfactant Tuning
Authors: Sheng Pengtao , Xu Haiyan , Zhang Yaqi , Xia Haiyue , Liu Haipeng , Li Weili 
Published: December 2024

AbstractThe shape and size‐controlled synthesis of colloidal I−III−VI quantum dots (QDs) can be attained only by a few synthesis strategies via the introduction of various high‐boiling‐point organic surfactants. To further investigate this strategy, in this study, we present a surfactant‐associated controlled synthesis of copper (Cu)‐deficient, zinc (Zn)‐doped Cu─indium (In)─selenium (Se) QDs, followed by a mechanistic investigation of their photophysical properties using surfactants, such as oleylamine (OLA), oleic acid (OA), and diphenylphosphine (DPP). OLA significantly promoted the quantum size effect‐resultant emission wavelength red‐shift, while OA controlled the homogeneous growth of QDs and improved the quantum yields. Moreover, Gaussian deconvolution of the photoluminescence spectra and the bandgap derived from the absorption spectra, by fitting, supported the fact that the radiative transition channels, especially for surface‐trap‐state‐related transitions, are also dependent on the surfactants. Specifically, the conduction band electron‐intragap state transitions and donor‐acceptor transitions were present in all the prepared samples but accounted for different percentages. Furthermore, the surface‐trap‐state‐related transitions significantly faded upon adding (i) OLA/OA as the sole surfactant to the cationic precursor and (ii) the OA + OLA + DPP mixture to the anionic precursor. The findings described here are expected to provide a general strategy for enhancing the tunability of photophysical properties in other QDs systems.
Self‐Cascade API Nanozyme for Synergistic Anti‐Inflammatory, Antioxidant, and Ferroptosis Modulation in the Treatment of Corneal Neovascularization
Authors: Wang Hongwei , Yang Yang , Yu Huimin , Ma Li , Qi Xia , Qu Junpeng , Zhang Xiaoyu , Li Na , Dou Shengqian , Liu Xiaoxue , Wei Chao , Gao Hua 
Published: December 2024

AbstractCorneal neovascularization is a common pathological ocular change that can severely impairs vision, potentially leading to blindness. Although steroids and non‐steroidal anti‐inflammatory drugs are the primary treatments, their side effects, such as ocular hypertension, eye irritation, and corneal lysis, limit their widespread use. In the present study, an active pharmaceutical ingredient (API) nanozyme (PC‐DS NE) is developed through the metal–organic coordination of ferrous sulfate with the anti‐inflammatory agent diclofenac sodium and the natural antioxidant proanthocyanidin. PC‐DS NE exhibited a spheroid morphology with a particle size of 39.7 ± 5.2 nm, and could achieve the short‐term release of diclofenac sodium and sustained release of proanthocyanidin. Notably, the PC‐DS NE possessed favorable biocompatibility, self‐cascade redox regulation capacity, and significant anti‐inflammatory activity. In corneal alkali burn experiments, PC‐DS NE effectively inhibited corneal neovascularization by scavenging reactive oxygen species, inhibiting the expression of inflammatory cytokines and pro‐angiogenic factors, and down‐regulating ferroptosis. These synergistic effects highlighted the potential of PC‐DS NE as a promising treatment for ocular inflammatory diseases.