bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural characteristics and mechanisms of fluorapatite mechanochemical synthesis
Authors: Jokanović Vukoman , Čolović Božana , Sandić-Živković Marija , Bajić Marijana Popović , Živković Slavoljub 
Published: April 2019

Abstract
This paper analyzes mechanisms of fluorapatite mechanochemical synthesis and its structural characteristics. Several studies of Jokanovic et al. published in appropriate journals and the book “Nanomedicine, the biggest challenge of the 21st century” are the base for this article. Characteristics of obtained materials show numerous biological advantages associated with the specific structural design of material during the process of synthesis. X-ray diffraction (XRD) and infrared spectroscopy with Fourier transform (FTIR) were used for studying the processes of fluorapatite synthesis.
Dental pulp pain in young and postmenopausal women: a pilot study
Authors: Krunić Jelena , Mladenović Irena , Stojanović Nikola 
Published: April 2019

Abstract
Introduction This pilot study was aimed to compare pulpal pain provoked by electrical and thermal (cold) stimuli in healthy young women during various phases of menstrual cycle and postmenopausal women.
Material and methods The study included 20 regularly menstruating healthy women and 20 postmenopausal women. Electrical (electrical pulp tester) and cold (refrigerant spray) stimuli were performed on mandibular central incisors, twice in regularly menstruating (menstrual and luteal phases) and once in postmenopausal women. Results were expressed as pain threshold values for electrical pulp stimulation (0-80 units) and pain intensity scores (visual numeric scale, from 0 to 10) for cold stimulation.
Results In young women, higher pain electrical threshold (p=0.484) and pain sensitivity score (p=0.015) were observed in luteal in comparison to menstrual phase. In postmenopausal women, electrical pain threshold was significantly higher while pain intensity score was significantly lower than in young women, regardless of the menstrual phase and painful stimuli.
Conclusion Lower responsiveness to dental pulp pain was obtained in young women in luteal phase and postmenopausal women.
Original article. Dental and Jaws Status in Pre-historic Human Population of the Gomolava Site
Authors: Grga Đurica , Mikić Ilija , Lisul Bogdan , Zlopaša Tamara , Dželetović Bojan 
Published: April 2019

Summary
Introduction Knowledge of biological and cultural heritage represents a significant basis for the advance of human civilization. The aim of this study was to determine and define dental health status of pre-historic people of the Vinca culture.
Material and method Study included twenty skeleton remnants of different gender and age from anthropological series of Gomolava. Skeletons originated from one necropolis and two individual graves dating from mid and early Neolithic periods of the Vinca culture. Based on radiocarbon analysis absolute skeletal age was determined to date within the periods from 5848±38 to 5739±35 BC. Preservation of skeletons varied from completely preserved skulls and jaws to fragmented parts of jaws. Data analysis was performed with methodology used in the research of human population teeth and jaws from the Lepenski Vir culture.
Results Results showed high level of teeth abrasion (98,1%), medium level of dental calculus deposits (44,9%), low level of tooth decay, significant number of retained roots, as well as the occurrence of periapical lesions and periodontal disease within the neolith population of Gomolava site.
Conclusion Taking into account absolute age of examined skeletons, collected data are very significant, from the perspective of its wide content. From a pathological perspective, teeth abrasion stands out as a dominant feature, while tooth decay fits within standard values for human population of the neolith period.
Anterior hypopituitarism secondary to biopsy-proven IgG4-related hypophysitis in a young man
Authors: Joshi H , Hikmat M , Devadass A P , Oyibo S O , Sagi S V 
Published: April 2019

Summary
IgG4-related disease (IgG4-RD) is an immune-mediated fibro-inflammatory condition which can affect various organs including the pituitary gland. The true annual incidence of this condition remains widely unknown. In addition, it is unclear whether IgG4 antibodies are causative or the end result of a trigger. With no specific biomarkers available, the diagnosis of IgG4-related hypophysitis remains a challenge. Additionally, there is a wide differential diagnosis. We report a case of biopsy-proven IgG4-related hypophysitis in a young man with type 2 diabetes mellitus.

Learning points:

IgG4-related hypophysitis is part of a spectrum of IgG4-related diseases.

Clinical manifestations result from anterior pituitary hormone deficiencies with or without diabetes insipidus, which can be temporary or permanent.

A combination of clinical, radiological, serological and histological evidence with careful interpretation is required to make the diagnosis.

Tissue biopsy remains the gold standard investigation.

Disease monitoring and long-term management of this condition is a challenge as relapses occur frequently.
Escarabajos (coleópteros) de Perú: un reconocimiento de las familias. Attelabidae Billberg, 1820
Authors: Legalov Andrei A. 
Published: April 2019

Se describe una nueva especie, Omolabus (Sternolaboides) sokolovi Legalov n. sp. de Satipo, centro de Perú. Se registran nuevos datos para Hybolabus ater (Olivier, 1789), Omolabus (Perulabus) peruanus Legalov, 2004, O. (Pseudomolabus) westerduijni Legalov, 2008 y O. (Sternolaboides) ecuadorensis Legalov, 2007. Basada en la literatura y exámenes de muestras, se elabora una lista de las 18 especies peruanas de Attelabidae, pertenecientes a ocho géneros de dos tribus, tambien se presentan sus distribuciones en Perú.
Publicación registrada en Zoobank/ZooBank article registered:LSIDurn:lsid:zoobank.org:pub:6C34BBEA-04C7-446B-8327-64F1A2FC0885Acto nomenclatural/nomenclatural act:LSIDurn:lsid:zoobank.org:act:F19261C5-A71F-48B1-B5C9-C868736B0AE9
Caracterización molecular de bacterias con potencial probiótico aisladas de heces de neonatos humanos
Authors: Santos Ricardo , Paitán Elizabeth , Sotelo Alejandrina , Zúñiga Doris , Vílchez Carlos 
Published: April 2019

El objetivo de este estudio es caracterizar molecularmente bacterias con potencial probiótico aisladas de heces de neonatos humanos. Se evaluó 60 muestras de heces de neonatos (0-3 días) se enriquecieron en caldo Man Rogosa y Sharp (MRS) a 37°C/24h. Se seleccionó y se sometió a pruebas in vitro con sales biliares, resistencia a pH bajo y actividad antimicrobiana frente a Escherichia coli ATCC25922, E. coli ATCC35218, Salmonella enterica y Listeria inocua mediante el ensayo difusión en agar. La identificación molecular se realizó con amplificaciones PCR-BOX y el secuenciamiento del gen 16S rRNA. Se aislaron un total de 48 cepas y todas presentaron resistencia a pH 3 y 0.3% sales biliares; 3 cepas mostraron actividad antimicrobiana frente a E. coli ATCC25922, 1 cepa frente a E. coli ATCC35218, 5 cepas frente a L. inocua y todas frente a S. entérica. De las 48 cepas se obtuvieron dos perfiles BOX-PCR pertenecientes a los géneros de Lactobacillus y Enterococcus. Nueve cepas (C52, C61, C71, C112, C16 2, C192, C20, C35, y C42) presentaron un 100% de similaridad a L. plantarum ATCC 14917T [ACGZ01000098] y dos cepas (C15 y C40) un 99.93% y 99.80% de similaridad, respectivamente a Enterococcus faecium CGMCC 1.2136T [AJKH01000109]; estas cepas mostraron actividad en leche con diferencias significativas (p valor < 0.05) en la cinética de pH 3. En conclusión se encontró bacterias con potencial probiótico.
TULISAN jAWI SEBAGAI WARISAN INTELEKTUAL ISLAM MELAYU DAN PERANANNYA DALAM KAJIAN KEAGAMAAN DI NUSANTARA
Authors: Senen Masyhur Dungcik 
Published: April 2019

ABSTRAK

Penelitian ini dilatarbelakangi oleh adanya fakta sejarah yang menunjukkan peran penting tulisan Jawi dalam berbagai aspek, sejak masuk Islam ke nusantara dan berlangsung selama sekitar dua abad lamanya. Pada saat itu tulisan Jawi menjadi satu-satunya media penyampaian dan pengembangan ajaran agama Islam. Peran ini mulai hilang sejak munculnya sistem tulisan latin yang menggantikan sistem tulisan Jawi dalam bahasa Melayu hingga sekarang. Penelitian ini bertujuan untuk mengetahui bagaimana awal mula tulisan Jawi berperan dan peranannya serta pada bidang apa saja tulisan Jawi memainkan peranannya dalam kajian keagamaan di nusantara. Permasalahan utama yang dikaji dalam dalam penelitian ini adalah mengenai: 1) kapan tulisan Jawi berperan dalam kajian keagamaan di nusantara?, 2) bagaimana peranan tulisan Jawi dalam kajian keagamaan di nusantara? dan; 3) pada bidang apa saja tulisan Jawi memainkan peranannya dalam kajian keagamaan di nusantara?. Data penelitian ini dianalisis dengan menggunakan teori masuknya Islam di Nusantara dan perkembangan Bahasa Melayu di Nusantara. Dari hasil analisis diperoleh kesimpulan bahwa tulisan Jawi mulai memegang peranan penting sejak berkembangnya agama Islam di wilayah ini terutama dalam kajian keagamaan. Peran penting ini dibuktikan dengan adanya penggunaan tulisan Jawi dalam sebagian besar naskah keagamaan yang pernah ditemukan di nusantara itu, dan digunakan dalam berbagai lembaga kajian keagamaan di nusantara pada masa itu. Terdapat 900 judul kitab kuning yang sebagian besarnya dalam tulisan Jawi, meliputi bidang-bidang ilmu Fiqh, Akidah/Ushuluddin, Nahwu, Kumpulan hadits, Tasawwuf dan Tariqat, Akhlak, Doa/Wirid dan Mujarabat, dan Kisah Anbiya/Maulid/Manaqib, dan ditemukan 114 (Seratus Empat Belas) naskah yang berbicara tentang keagamaan dalam bidang-bidang ilmu tersebut. Temuan ini menunjukkan bahwa tulisan Jawi memainkan peranannya dalam berbagai bidang kajian keagamaan di nusantara
Application of an Innovative Drilling Simulator Set Up to Test Inhibitive Mud Systems for Drilling Shales
Authors: Konate Nabe , Ezeakacha Chinedum Peter , Salehi Saeed , Mokhtari Mehdi 
Published: April 2019

Abstract
Wellbore instability is caused by the radical change in the mechanical strength as well as chemical and physical alterations when exposed to drilling fluids. A set of unexpected events associated with wellbore instability in shales account for more than 10% of drilling cost, which is estimated to one billion dollars per annum. Understanding shale-drilling fluid interaction plays a key role in minimizing drilling problems in unconventional resources. The need for efficient inhibitive drilling fluid system for drilling operations in unconventional resources is growing. This study analyzes different drilling fluid systems and their compatibility in unconventional drilling to improve wellbore stability.
A set of inhibitive drilling muds including cesium formate, potassium formate, and diesel-based mud were tested on shale samples with drilling concerns due to high-clay content. An innovative high-pressure high temperature (HPHT) drilling simulator set-up was used to test the mud systems. The results from the test provides reliable data that will be used to capture more effective drilling fluid systems for treating reactive shales and optimizing unconventional drilling.
This paper describes the use of an innovative drilling simulator for testing inhibitive mud systems for reactive shale. The effectiveness of inhibitive muds in high-clay shale was investigated. Their impact on a combination of problems, such high torque and drag, high friction factor, and lubricity was also assessed. Finally, the paper evaluates the sealing ability of some designed lost circulation material (LCM) muds in a high pressure high temperature environment.
Transient Multiphase Analysis of Well Trajectory Effects in Production of Horizontal Unconventional Wells
Authors: Tran Ngoc , Karami Hamidreza 
Published: April 2019

Abstract
The effects of horizontal well geometry remain debatable in most production modeling works. Most of recent reports fail to mention the effects of well geometries, especially in severe slugging cases. This study presents a qualitative comparison between different well geometries and their impacts in production performance of horizontal wells.
The study utilizes a transient multiphase simulator to mimic the production from a horizontal well over a 12-hour period. The well has a 2-7/8″ ID tubing with TVD of approximately 5000 ft and MD of 10000 ft and maximum inclination angle of 10º within the horizontal section. The trajectories of horizontal section in the well include 5 cases, 5 undulations, hump (one undulation upward), sump (one undulation downward), toe-up and toe-down. These configurations are the representative examples of horizontal wells. A reservoir with a given deliverability equation and several perforation stages is used to provide well inflow. The impacts of reservoir deliverability, GOR, pressure and temperature are studied for all well geometries.
The simulation results offer some valuable insights into the effects of well trajectory on production performance, including borehole pressure profile, liquid holdup, gas and liquid rate variations with time, and cumulative gas and liquid production. At high production rates, severe slugging is not observed, and thus, the well geometry effects are minimized with a consistent production at the surface. However, toe-up configuration exhibits a slightly better performance than the others.
As the productivity and pressure reduces throughout the life of a well, the impacts of well trajectories become clearer. The presence of severe slugs and blockage of perforations near the toes causes a noticeable drop in production. During severe slugging, the pressure profile reveals longer fluctuation cycles, resulting in extreme separator flooding issues. The slugging frequencies are compared among different well geometries. Toe-down case exhibits lower slugging severity. As a result, toe-down well produces the highest cumulative liquid and gas rates. The presence of liquid blockage is observed in lateral and curvature sections. The toe-up and hump configurations exhibit the most severe slugs with minimum cumulative gas and liquid productions. The differences in productions among well trajectories exceed 30% under different well configurations.
With the augmented growth of production from unconventional reservoirs, horizontal well technology has grown in oil and gas industry, yet study of well geometry in production system remains to be limited. This study is a unique effort to optimize well configuration and perforation placement in order to alleviate multiphase flow problems in the wellbore. Providing the practical potential on simulation works, this study provides a predictive guidline to connect well geometry selection and production optimization.
Detecting influenza and emerging avian influenza virus by influenza and pneumonia surveillance systems in a large city in China, 2005 to 2016
Authors: Guo Xiaorong , Yang Dong , Liu Ruchun , Li Yaman , Hu Qingqing , Ma Xinrui , Li Yelan , Zhang Heng , Zhang Xixing , Zhao Benhua , Chen Tianmu 
Published: April 2019

Abstract
Background: Detecting avian influenza virus has become an important public health strategy for controlling the emerging infectious disease. This study aimed to analyze the efficiency of two surveillance systems in detecting the emerging avian influenza viruses.
Methods: A modified influenza surveillance system (ISS) and a new built pneumonia surveillance system (PSS) have been used to monitor the viruses in Changsha City, China. The ISS is based on monitoring outpatients in two sentinel hospitals to detect mild influenza and avian influenza cases, and PSS is based on monitoring inpatients in all 49 hospitals to detect severe and death influenza cases.
Results: During the study period, 3551917 outpatients were monitored by the ISS system, among which 126076 were influenza-like illness (ILI) cases, with the ILI% of 3.55%. Totally, 14913 throat swabs were collected by the ISS system, among which 2016 were tested positive of influenza or avian influenza virus. Among the positive results, 621 were H3N2, 135 were seasonal H1N1, 610 were influenza A/H1N1 (pandemic in 2009), 106 were untyped influenza A, 540 were B, 1 was H5N6, 1 was H7N9, and 2 were H9N2 virus. 5491560 inpatient people were monitored by the PSS system, among which 6.61% (362743/5491560) were pneumonia cases. 10.55% (38260/362743) of reported pneumonia was severe or death cases. 3401 throat swab or lower respiratory tract samples were collected, among which 2094 were tested positive of influenza or avian influenza virus. Among the positive results, 78 were H3N2, 17 were seasonal H1N1, 1871 were influenza A/H1N1, 103 were untyped influenza A, 16 were B, 1 was H5N6, and 8 were H7N9 virus. Of 15 avian influenza cases reported from January, 2005 to September, 2016, 26.7% (4/15) were mild cases detected by the ISS system, while 60.0% (9/15) were severe or death cases detected by the PSS system. Two H5N1 severe cases were missed by the ISS system in January, 2009 when the PSS system was not available.
Conclusion: The two systems seem to be of high efficiency in detecting the emerging avian influenza viruses but need to be verified in other cities or countries.
The effect of implementing an aseptic practice bundle for anaesthetists to reduce postoperative infections. Protocol for a stepped wedge, cluster randomised, multi-site trial. The Anaesthetists Be Cleaner (ABC) Study.
Authors: Merry Alan F , Gargiulo Derryn , Bissett Ian , Cumin David , English Kerry , Frampton Christopher , Hamblin Richard , Hannam Jacqueline , Moore Matthew , Reid Papaarangi , Roberts Sally , Taylor Elsa , Mitchell Simon J 
Published: April 2019

Abstract
Background

Postoperative infection is a serious problem in New Zealand, and internationally with considerable human and financial costs. Also, in New Zealand, certain factors that contribute to postoperative infection are more common in Māori and Pacific populations. To date, most efforts to reduce postoperative infection have focused on surgical aspects of care and on antibiotic prophylaxis, but recent research shows that anaesthesia providers may also have an impact on infection transmission. These providers sometimes exhibit imperfect hand hygiene and frequently transfer the blood or saliva of their patients to their work environment. In addition, intravenous medications may become contaminated while being drawn up and administered to patients. Working with relevant practitioners and other experts, we have developed an evidence-informed bundle to improve key aseptic practices by anaesthetists with the aim of reducing postoperative infection. The key elements of the bundle are the filtering of compatible drugs, context-relevant hand hygiene practices, and enhanced maintenance of clean work surfaces.

Methods

We will seek support for implementation of the bundle from senior anaesthesia and hospital leadership and departmental “champions”. Anaesthetic teams and recovery room staff will be educated about the bundle and its potential benefits through presentations, written material, and exemplar videos. We will implement the bundle in operating rooms where hip or knee arthroplasty or cardiac surgery procedures are undertaken in a five-site, stepped wedge, cluster randomised, quality improvement design. We will compare outcomes between approximately 5,000 cases before and 5,000 cases after implementation of our bundle. Outcome data will be collected from existing national and hospital databases. Our primary outcome will be days alive and out of hospital to 90 days, which is expected to reflect all serious postoperative infections. Our secondary outcome will be the rate of surgical site infection. Aseptic practice will be observed in sampled cases in each cluster before and after implementation of the bundle.

Discussion

If effective, our bundle may offer a practical clinical intervention to reduce postoperative infection and its associated substantial human and financial costs.

Trial registration

Australian New Zealand Clinical Trials Network Registry: ACTRN12618000407291
ETIOLOGICAL VERIFICATION OF TUBERCULOSIS IN CASE OF SYSTEM INFLAMMATORY SYNDROME IN HIV PATIENTS
Authors: Vladimirov K. B. , Marfina G. Yu. , Karaseva E. V. , Damadanov B. D. , Zhuravlev V. Yu. 
Published: April 2019

The objective: to study the efficacy of etiological verification of tuberculosis in case of systemic inflammation syndrome in HIV patients. Subjects and methods. 116 HIV patients were examined; all of them were admitted to hospital due to systemic inflammatory syndrome (SIS). In order to diagnose tuberculosis, clinical, bacteriological, and instrumental examinations were performed. Specimens of venous blood were used for the detection of tuberculous mycobacteria by RT-PCR and culture. Results. More than half (64.6%) of cases of systemic inflammatory syndrome in the examined HIV patients was due to tuberculosis onset. The degree of immunity suppression (considering CD4 count) in SIS patients with tuberculosis onset and various HIV-associated pathologies was not statistically significantly different. The frequency of MTB DNA detection by RT-PCR in venous blood in case of verified tuberculous sepsis (non-academic term) in TB/HIV patients made 29.3%, and taking into account positive results of blood culture in 5 patients with no MTB DNA found in the blood, the efficiency of diagnosis of tuberculosis in blood specimens reached 33.3%, while efficiency of blood cultures for MTB made 36.0%, with 100% specificity. Repeated PCR tests and blood cultures performed in some patients allowed increasing the total efficiency of blood tests.
THE SURGICAL STAGE OF PULMONARY TUBERCULOSIS TREATMENT USING MOLECULAR-GENETIC METHODS TO TEST SUSCEPTIBILITY TO RIFAMPICIN
Authors: Golovnin A. V. , Khanin A. L. , Golovnin V. I. 
Published: April 2019

The objective of the study: to analyze the frequency and patterns of drug resistance of Mycobacterium tuberculosis (MTB) according to the results of microbiological tests of surgical specimens of the patients who underwent surgery due to tuberculosis, and to compare them with the results of sputum tests done in the pre-operative period. Subjects and methods. The data of surgical specimens from 170 patients operated due to tuberculosis were analyzed. The surgical specimens were sent for histological and microbiological tests (detection of MTB DNA and rifampicin resistance by GeneXpert, culture on solid media with drug sensitivity testing). Results. The molecular genetic testing of surgical specimens by GeneXpert was highly effective for detection of rifampicin resistance; in 97.8% of cases, there was a match with the results of sputum culture with consecutive DST performed before the surgery. Molecular genetic tests of surgical specimens allowed detecting MTB DNA in 66.1% of patients in whom no MTB or MTB DNA was detected in sputum and bronchial washings prior to the surgery, and of them in 28.2% of cases, rifampicin resistance was detected, which was unknown before the surgery. These data allowed prescribing adequate chemotherapy immediately after surgery.