bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Mental Health Service Utilization Among Men: A Systematic Review and Synthesis of Behavior Change Techniques Within Interventions Targeting Help-Seeking
Authors: Sagar-Ouriaghli Ilyas , Godfrey Emma , Bridge Livia , Meade Laura , Brown June S.L. 
Published: June 2019

Compared to women, men are less likely to seek help for mental health difficulties. Despite considerable interest, a paucity in evidence-based solutions remains to solve this problem. The current review sought to synthesize the specific techniques within male-specific interventions that may contribute to an improvement in psychological help-seeking (attitudes, intentions, or behaviors). A systematic review identified 6,598 potential articles from three databases (MEDLINE, EMBASE, and PsycINFO). Nine studies were eligible. A meta-analysis was problematic due to disparate interventions, outcomes, and populations. The decision to use an innovative approach that adopted the Behavior Change Technique (BCT) taxonomy to synthesize each intervention’s key features likely to be responsible for improving help-seeking was made. Of the nine studies, four were engagement strategies (i.e., brochures/documentaries), two randomized controlled trials (RCTs), two pilot RCTs, and one retrospective review. Regarding quality assessment, three were scored as “strong,” five as “moderate,” and one as “weak.” Key processes that improved help-seeking attitudes, intentions, or behaviors for men included using role models to convey information, psychoeducational material to improve mental health knowledge, assistance with recognizing and managing symptoms, active problem-solving tasks, motivating behavior change, signposting services, and, finally, content that built on positive male traits (e.g., responsibility and strength). This is the first review to use this novel approach of using BCTs to summarize and identify specific techniques that may contribute to an improvement in male help-seeking interventions, whether engagement with treatment or the intervention itself. Overall, this review summarizes previous male help-seeking interventions, informing future research/clinical developments.
A novel, hybrid, single- and multi-site clinical trial design for CLN3 disease, an ultra-rare lysosomal storage disorder
Authors: Adams Heather R , Defendorf Sara , Vierhile Amy , Mink Jonathan W , Marshall Frederick J , Augustine Erika F 
Published: June 2019

Background Travel burden often substantially limits the ability of individuals to participate in clinical trials. Wide geographic dispersion of individuals with rare diseases poses an additional key challenge in the conduct of clinical trials for rare diseases. Novel technologies and methods can improve access to research by connecting participants in their homes and local communities to a distant research site. For clinical trials, however, understanding of factors important for transition from traditional multi-center trial models to local participation models is limited. We sought to test a novel, hybrid, single- and multi-site clinical trial design in the context of a trial for Juvenile Neuronal Ceroid Lipofuscinosis (CLN3 disease), a very rare pediatric neurodegenerative disorder. Methods We created a “hub and spoke” model for implementing a 22-week crossover clinical trial of mycophenolate compared with placebo, with two 8-week study arms. A single central site, the “hub,” conducted screening, consent, drug dispensing, and tolerability and efficacy assessments. Each participant identified a clinician to serve as a collaborating “spoke” site to perform local safety monitoring. Study participants traveled to the hub at the beginning and end of each study arm, and to their individual spoke site in the intervening weeks. Results A total of 18 spoke sites were established for 19 enrolled study participants. One potential participant was unable to identify a collaborating local site and was thus unable to participate. Study start-up required a median 6.7 months (interquartile range = 4.6–9.2 months). Only 33.3% (n = 6 of 18) of spoke site investigators had prior clinical trial experience, thus close collaboration with respect to study startup, training, and oversight was an important requirement. All but one participant completed all study visits; no study visits were missed due to travel requirements. Conclusions This study represents a step toward local trial participation for patients with rare diseases. Even in the context of close oversight, local participation models may be best suited for studies of compounds with well-understood side-effect profiles, for those with straightforward modes of administration, or for studies requiring extended follow-up periods.
Potential drug–drug interactions and associated factors among hospitalized cardiac patients at Jimma University Medical Center, Southwest Ethiopia
Authors: Diksis Netsanet , Melaku Tsegaye , Assefa Desta , Tesfaye Andualem 
Published: June 2019

Background: Concomitant use of several drugs for a patient is often imposing increased risk of drug–drug interactions. Drug–drug interactions are a major cause for concern in patients with cardiovascular disorders due to multiple co-existing conditions and the wide class of drugs they receive. This study is aimed to assess the prevalence of potential drug–drug interactions and associated factors among hospitalized cardiac patients at medical wards of Jimma University Medical Center, Southwest Ethiopia. Methods: A hospital-based prospective observational study was conducted among hospitalized cardiac adult patients based on the inclusion criteria. Patient-specific data were collected using structured data collection tool. Potential drug–drug interaction was analyzed using Micromedex 3.0 DRUG-REAX® System. Data were analyzed using statistical software package, version 20.0. To identify the independent predictors of potential drug–drug interaction, multiple stepwise backward logistic regression analysis was done. Statistical significance was considered at a p-value < 0.05. Written informed consent from patients was obtained and the patients were informed about confidentiality of the information obtained. Results: Of the total 200 patients, majority were male (52.50%) and with a mean(±standard deviation) age of 42.54(±7.89) years. Out of 673 patients’ prescriptions analyzed, 521 prescriptions comprised potential drug interactions and it was found that 967 drug interactions were present. The prevalence rate of potential drug–drug interactions among the study unit was 4.83 per patient and 1.44 per prescription regardless of the severity during their hospital stay. Overall the prevalence rate of potential drug interactions was 74.41%. Older age (adjusted odds ratio (95% confidence interval): 1.067 (2.33–27.12), p = 0.049), long hospital stay (⩾7 days) (adjusted odds ratio (95% confidence interval): 2.80 (1.71–4.61), p = 0.024), and polypharmacy (adjusted odds ratio (95% confidence interval): 1.64 (0.66–4.11), p = 0.041) were independent predictors for the occurrence of potential drug–drug interactions. Conclusion: This study demonstrated a high prevalence of potential DIs among hospitalized cardiac patients in medical wards due to the complexity of pharmacotherapy. The prevalence rate is directly related to age, number of prescribed drugs, and length of hospital stay. Pharmacodynamic drug–drug interaction was the common mechanism of drug–drug interactions. Therefore, close monitoring of hospitalized patients is highly recommended.
Facebook support for breastfeeding mothers: A comparison to offline support and associations with breastfeeding outcomes
Authors: Robinson Ayanna , Lauckner Carolyn , Davis Marsha , Hall Jori , Anderson Alex Kojo 
Published: June 2019

Objectives For breastfeeding mothers, online support groups through Facebook may be a more convenient and preferred source for accessing breastfeeding information and support, but few studies exist that examine the use of Facebook groups specifically for breastfeeding support. This study explores the sources of support among users of Facebook breastfeeding support groups and a possible mechanism by which support received on Facebook may translate to behavioral outcomes among breastfeeding mothers. Methods From July–September 2017 a survey was distributed online to African American mothers ( N = 277) who participate in breastfeeding support groups on Facebook. The survey assessed network support from Facebook and other sources of breastfeeding support, perceived breastfeeding norms, breastfeeding self-efficacy and breastfeeding attitudes. Correlations and linear regression analysis were used to examine the relationship between covariates and outcome variables. Results The average intended breastfeeding duration among participants in this study was 19 months. Participants reported the highest amount of breastfeeding support received from their Facebook support group, in comparison to other sources of support, and Facebook support was significantly correlated with intended breastfeeding duration ( p < 0.05). Self-efficacy and breastfeeding attitudes remained significant predictors of intended breastfeeding duration within the final regression model. Conclusions Breastfeeding support received within Facebook groups may compensate for inadequate support received within mothers’ networks. More research is needed to understand the mechanism through which Facebook support may contribute to prolonged breastfeeding durations.
Intra- and inter-rater reliability in a comparative study of cross-sectional and spiral computed tomography pelvimetry methods
Authors: Phexell Erika , Åkesson Anna , Söderberg Marcus , Bolejko Anetta 
Published: June 2019

Background Different low-dose computed tomography (CT) pelvimetry methods can be used to evaluate the size of birth canal before delivery. CT pelvimetry might generate an acceptable low fetal radiation dose but its measurement accuracy is unknown. Purpose To investigate intra- and inter-rater measurement reliability of cross-sectional and two spiral CT pelvimetry methods: standard spiral and short spiral. Material and Methods Ten individuals (age ≥60 years, body mass index ≥30 kg/m2) having a CT scan of the abdomen also had CT pelvimetry scans. Three radiologists made independent measurements of each pelvimetry method on two occasions and also in consensus for a reference pelvimetry computed from the standard-dose CT scan of the abdomen. Inter- and intra-rater reliability was analyzed by intraclass correlation coefficient. Results Measurements in the short spiral pelvimetry demonstrated excellent intra- and inter-rater reliability, intraclass correlation coefficient ≥0.93, and good to excellent 95% confidence interval 0.87–0.99. Corresponding results of the standard spiral and cross-sectional pelvimetry showed good to excellent intraclass correlation coefficient ≥0.85 and ≥0.76, and 95% confidence interval was least good and moderate 0.73–0.98 and 0.59–0.97, respectively. Intraclass correlation coefficient between reference pelvimetry and other CT methods showed analogous results. Conclusion The short spiral pelvimetry demonstrated high and best reliability in comparison to other methods. Standard spiral method showed also good measurement reliability but the short spiral pelvimetry generates lower fetal radiation dose. This method might be suitable for measurements at narrow pelvis. Patient acceptance and attitude to CT pelvimetry should be investigated.
Patient safety professionals as the third victims of adverse events
Authors: Holden Julie , Card Alan J 
Published: June 2019

Harm from adverse events does not always stop with patients and their families. In recent years, attention has been drawn to the plight of second victims, the healthcare workers involved in an incident, who can also experience significant harm. But even that does not tell the whole story. This article describes how those with indirect exposure to an adverse event can become the third victims of an adverse event, and focuses on the example of patient safety professionals responsible for incident investigation and improvement activities. We outline potential sources of harm, including critical incident stress, emotional labor, abusive supervision, and competing loyalties/duties. These stressors may cause symptoms of acute stress disorder or post-traumatic stress disorder, loss of confidence, and economic harm, and may even lead patient safety professionals to leave the profession. We also propose a number of actions to prevent or reduce harm to third victims, which include extending second victim support services to patient safety professionals, redesigning the patient safety role, providing board-level and senior management leadership, creating a culture of psychological safety, and tracking metrics related to third victims. Having drawn attention to this problem, we hope the research community will move forward with an agenda to more robustly characterize the sources and types of harm third victims experience, and to test interventions aimed at preventing and mitigating that harm.
Comprehensive viromewide antibody responses by systematic epitope scanning after hematopoietic cell transplantation
Authors: Bender Ignacio Rachel A. , Dasgupta Sayan , Stevens-Ayers Terry , Kula Tomasz , Hill Joshua A. , Lee Stephanie J. , Mielcarek Marco , Duerr Ann , Elledge Stephen J. , Boeckh Michael 
Published: June 2019

Abstract
Further insight into humoral viral immunity after hematopoietic cell transplantation (HCT) could have potential impact on donor selection or monitoring of patients. Currently, estimation of humoral immune recovery is inferred from lymphocyte counts or immunoglobulin levels and does not address vulnerability to specific viral infections. We interrogated the viral antibody repertoire before and after HCT using a novel serosurvey (VirScan) that detects immunoglobulin G responses to 206 viruses. We performed VirScan on cryopreserved serum from pre-HCT and 30, 100, and 365 days after myeloablative HCT from 37 donor-recipient pairs. We applied ecologic metrics (α- and β-diversity) and evaluated predictors of metrics and changes over time. Donor age and donor/recipient cytomegalovirus (CMV) serostatus and receipt systemic glucocorticoids were most strongly associated with VirScan metrics at day 100. Other clinical characteristics, including pre-HCT treatment and conditioning, did not affect antiviral repertoire metrics. The recipient repertoire was most similar (pairwise β-diversity) to that of donor at day 100, but more similar to pre-HCT self by day 365. Gain or loss of epitopes to common viruses over the year post-HCT differed by donor and recipient pre-HCT serostatus, with highest gains in naive donors to seropositive recipients for several human herpesviruses and adenoviruses. We used VirScan to highlight contributions of donor and recipient to antiviral humoral immunity and evaluate longitudinal changes. This work builds a foundation to test whether such systematic profiling could serve as a biomarker of immune reconstitution, predict clinical events after HCT, or help refine selection of optimal donors.
miRNA Profiling Reveals miRNA-130b-3p Mediates DENND1A Variant 2 Expression and Androgen Biosynthesis
Authors: McAllister Jan M , Han Angela X , Modi Bhavi P , Teves Maria E , Mavodza Grace R , Anderson Zachary L , Shen Tsaiwei , Christenson Lane K , Archer Kellie J , Strauss Jerome F 
Published: June 2019

Abstract
Polycystic ovary syndrome (PCOS) is a common endocrine disorder of reproductive-age women involving overproduction of ovarian androgens and, in some cases, from the adrenal cortex. Family studies have established that PCOS is a complex heritable disorder with genetic and epigenetic components. Several small, noncoding RNAs (miRNAs) have been shown to be differentially expressed in ovarian cells and follicular fluid and in the circulation of women with PCOS. However, there are no reports of global miRNA expression and target gene analyses in ovarian theca cells isolated from normal cycling women and women with PCOS, which are key to the elucidation of the basis for the hyperandrogenemia characteristic of PCOS. With the use of small RNA deep sequencing (miR-seq), we identified 18 differentially expressed miRNAs in PCOS theca cells; of these, miR-130b-3p was predicted to target one of the PCOS genome-wide association study candidates, differentially expressed in neoplastic vs normal cells domain containing 1A (DENND1A). We previously reported that DENND1A variant 2 (DENND1A.V2), a truncated isoform of DENND1A, is upregulated in PCOS theca cells and mediates augmented androgen biosynthesis in PCOS theca cells. The comparison of miR-130b-3p in normal and PCOS theca cells demonstrated decreased miR-130b-3p expression in PCOS theca cells, which was correlated with increased DENND1A.V2, cytochrome P450 17α-hydroxylase (CYP17A1) mRNA and androgen biosynthesis. miR-130b-3p mimic studies established that increased miR130b-3p is correlated with decreased DENND1A.V2 and CYP17A1 expression. Thus, in addition to genetic factors, post-transcriptional regulatory mechanisms via miR-130b-3p underly androgen excess in PCOS. Ingenuity® Pathway Analysis Core Pathway and Network Analyses suggest a network by which miR-130b-3p, DENND1A, the luteinizing hormone/choriogonadotropin receptor, Ras-related protein 5B, and signaling pathways that they potentially target may mediate hyperandrogenism in PCOS.
Soft Floors in Auctions
Authors: Zeithammer Robert 
Published: June 2019

Several of the auction-driven exchanges that facilitate programmatic buying of internet display advertising have recently introduced “soft floors” in addition to standard reserve prices (called “hard floors” in the industry). A soft floor is a bid level below which a winning bidder pays his own bid instead of paying the second-highest bid as in a second-price auction most ad exchanges use by default. This paper characterizes soft floors’ revenue-generating potential as a function of the distribution of bidder independent private values. When bidders are symmetric (identically distributed), soft floors have no effect on revenue, because a symmetric equilibrium always exists in strictly monotonic bidding strategies, and standard revenue-equivalence arguments thus apply. The industry often motivates soft floors as tools for extracting additional expected revenue from an occasional high bidder, for example a bidder retargeting the consumer making the impression. Such asymmetries in the distribution of bidder preferences do not automatically make soft floors profitable. This paper presents two examples of tractable modeling assumptions about such occasional high bidders, with one example implying low soft floors always hurt revenues because of strategic bid-shading by the regular bidders, and the other example implying high soft floors can increase revenues by making the regular bidders bid more aggressively. This paper was accepted by Juanjuan Zhang, marketing.
Opowieść o wygnaniu na Zachód
Authors: As-Suhrawardī Šihāb ad-Dīn Yaḥyà 
Published: June 2019

Opowieść o wygnaniu na Zachód (Qiṣṣat al-ġurba al-ġarbiyya) jest tłumaczeniem krótkiego dzieła Šihāb ad-Dīna Yaḥyi as-Suhrawardīego (1154-1191). Tłumaczenie i opracowanie: Łukasz Piątak, Uniwersytet im. Adama Mickiewicza, Poznań
Modeling the Induction Hardening of High-Carbon Saw Blades
Authors: Torres H. , Pérez-González F. A. , Zapata-Hernández O. , Garza-Montes-deOca N. F. , Ramírez-Ramírez J. H. , Fried Z. , Felde I. , Réger M. , Colás R. 
Published: June 2019

Abstract
Saws for food processing are designed to exhibit good resistance to corrosion and wear during service; the saws are made from high-carbon steel and are subjected to induction hardening to achieve the required properties. Such process offers good industrial advantages because heating is done at specific regions during very short times without heating all the material. The localized heating allows for the rapid cooling of the heated-up regions that result in transformation to austenite. This work presents the results of the simulation of induction heating using the finite and the boundary element methods to solve the heat transfer and electromagnetic phenomena. The model was coupled to a commercial package that considers the phase transformations occurring during the heating and quenching stages. The results of the simulation were validated with trials carried on site.
Crystal Viscoplasticity Model of Molybdenum Including the Influence of Silicon in Solid Solution
Authors: Brindley K. A. , Neu R. W. 
Published: June 2019

Abstract
Molybdenum (Mo)-based alloys offer higher temperature capability than nickel-based superalloys. The challenge of designing these alloys is tailoring the chemistry and microstructure to achieve high-temperature strength, creep and fatigue resistance, and oxidation resistance while maintaining lower-temperature ductility and damage tolerance. Structure-properties modeling tools can be used to identify optimum microstructures. However, one missing element in this tool set is a constitutive model for the more ductile α-Mo phase over the entire temperature range from room temperature to 1,400°C. A crystal viscoplasticity model is developed for α-Mo, including the influence of varying amounts of silicon (Si) in solid solution. The temperature, strain rate, and Si dependence of the deformation behavior needed to determine the model parameters are obtained from new compression experiments.
VALORIZAÇÃO DOS RESÍDUOS ORGÂNICOS DO SETOR DE HORTIFRUTIGRANJEIRO PELO PROCESSO DE COMPOSTAGEM DOMÉSTICA
Authors: Da Rosa Liciane Oliveira , De Souza Tatiana Porto , De Oliveira Vanessa Faria , Corrêa Luciara Billhalva , Corrêa Érico Kunde 
Published: June 2019

Os resíduos orgânicos são responsáveis por 50% dos resíduos gerados nos municípios brasileiros, e grande parte não tem manejo eficiente e são depositados em aterros sanitários ou aterros à céu aberto, ocasionando impactos negativos ao meio ambiente. O setor de hortifrutigranjeiros de comércios de distribuição alimentícios e, também, de feiras livres são responsáveis por gerar grandes quantidades de resíduos orgânicos. Uma forma de tratar esses resíduos ambientalmente correta é por meio do processo de compostagem, que é uma técnica de reciclagem simples, que transforma os resíduos em um composto orgânico de valor agronômico, podendo ser realizada em grande ou pequena escala e ser praticada em ambientes domiciliares, como uma excelente maneira de tratar os resíduos orgânicos diretamente no local de geração. Assim, esse trabalho teve como objetivo a valorização dos resíduos orgânicos que são passíveis de impacto ao meio ambiente, gerados no setor hortifrutigranjeiro, em um estabelecimento comercial, situado no município de Pelotas, RS, pelo processo de compostagem doméstica. Foi realizado um experimento com dois tratamentos e duas repetições com os resíduos orgânicos, onde foi realizado monitoramento primário próximo à realidade do usuário de composteira doméstica. Os parâmetros monitorados abrangeram temperatura externa, interna e umidade. Com este estudo, foi possível confirmar a capacidade de tratar os resíduos orgânicos por meio da compostagem doméstica com resíduos do setor hortifrutigranjeiros, além de demonstrar vantagens na utilização do composto orgânico obtido para cultivo de temperos e hortaliças.

Palavras-chave: Compostagem. Composto orgânico. Impacto ambiental.