bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus
Authors: Munz Matthias , Richter Gesa M. , Loos Bruno G. , Jepsen Søren , Divaris Kimon , Offenbacher Steven , Teumer Alexander , Holtfreter Birte , Kocher Thomas , Bruckmann Corinna , Jockel-Schneider Yvonne , Graetz Christian , Munoz Loreto , Bhandari Anita , Tennstedt Stephanie , Staufenbiel Ingmar , van der Velde Nathalie , Uitterlinden André G. , de Groot Lisette C. P. G. M. , Wellmann Jürgen , Berger Klaus , Krone Bastian , Hoffmann Per , Laudes Matthias , Lieb Wolfgang , Franke Andre , Dommisch Henrik , Erdmann Jeanette , Schaefer Arne S. 
Published: September 2018

AbstractEvidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset (60,801 cases vs 123,504 controls). Two SNPs at the known CAD risk loci ADAMTS7 (rs11634042) and VAMP8 (rs1561198) passed the pre-assigned selection criteria (PAgP-Ger < 0.05; PCAD < 5 × 10−8; concordant effect direction) and were replicated in an independent GWAS meta-analysis dataset of PD (4,415 cases vs 5,935 controls). SNP rs1561198 showed significant association (PD[Replication]: P = 0.008 OR = 1.09, 95% CI = [1.02–1.16]; PD [Discovery + Replication]: P = 0.0002, OR = 1.11, 95% CI = [1.05–1.17]). For the associated haplotype block, allele specific cis-effects on VAMP8 expression were reported. Our data adds to the shared genetic basis of CAD and PD and indicate that the observed association of the two disease conditions cannot be solely explained by shared environmental risk factors. We conclude that the molecular pathway shared by CAD and PD involves VAMP8 function, which has a role in membrane vesicular trafficking, and is manipulated by pathogens to corrupt host immune defense.
Stabilization of HIF-2α impacts pancreas growth
Authors: Flores-Martínez Alvaro , García-Núñez Alejandro , Rojas Anabel , Cano David A. 
Published: September 2018

AbstractHypoxia inducible factors (HIFs) are critical regulators of the response to oxygen deficiency by activating target genes involved in a variety of biological functions. HIFs have been implicated in the pathophysiology of numerous pathologies including cancer. Patients with mutations in the von Hippel-Lindau (VHL) gene, an essential regulator of HIF activity, develop tumors in several organs including the pancreas. Previous functional studies of HIF activation in the pancreas have used Vhlh (the murine homolog of VHL) deficient mice. However, the role of each specific HIF transcription factors in the pancreas has not been thoroughly examined. We derived mice that constitutively express a normoxia-stable form of HIF2α in the pancreas. Activation of HIF2α in the pancreas severely impairs postnatal exocrine pancreas. Mice with pancreas-specific activation of HIF2α develop histological features reminiscent of pancreatitis including loss of acinar cells, ductal dilation and fibrosis. Moreover, we provide evidence that signaling pathways important for acinar cell homeostasis are altered in HIF2α-overexpressing pancreata.
Strike-slip 23 January 2018 MW 7.9 Gulf of Alaska rare intraplate earthquake: Complex rupture of a fracture zone system
Authors: Krabbenhoeft Anne , von Huene Roland , Miller John J. , Lange Dietrich , Vera Felipe 
Published: September 2018

AbstractLarge intraplate earthquakes in oceanic lithosphere are rare and usually related to regions of diffuse deformation within the oceanic plate. The 23 January 2018 MW 7.9 strike-slip Gulf of Alaska earthquake ruptured an oceanic fracture zone system offshore Kodiak Island. Bathymetric compilations show a muted topographic expression of the fracture zone due to the thick sediment that covers oceanic basement but the fracture zone system can be identified by offset N-S magnetic anomalies and E-W linear zones in the vertical gravity gradient. Back-projection from global seismic stations reveals that the initial rupture at first propagated from the epicenter to the north, likely rupturing along a weak zone parallel to the ocean crustal fabric. The rupture then changed direction to eastward directed with most energy emitted on Aka fracture zone resulting in an unusual multi-fault earthquake. Similarly, the aftershocks show complex behavior and are related to two different tectonic structures: (1) events along N-S trending oceanic fabric, which ruptured mainly strike-slip and additionally, in normal and oblique slip mechanisms and (2) strike-slip events along E-W oriented fracture zones. To explain the complex faulting behavior we adopt the classical stress and strain partitioning concept and propose a generalized model for large intra-oceanic strike-slip earthquakes of trench-oblique oriented fracture zones/ocean plate fabric near subduction zones. Taking the Kodiak asperity position of 1964 maximum afterslip and outer-rise Coulomb stress distribution into account, we propose that the unusual 2018 Gulf of Alaska moment release was stress transferred to the incoming oceanic plate from co- and post-processes of the nearby great 1964 MW 9.2 megathrust earthquake.
DaReUS-Loop: accurate loop modeling using fragments from remote or unrelated proteins
Authors: Karami Yasaman , Guyon Frédéric , De Vries Sjoerd , Tufféry Pierre 
Published: September 2018

AbstractDespite efforts during the past decades, loop modeling remains a difficult part of protein structure modeling. Several approaches have been developed in the framework of crystal structures. However, for homology models, the modeling of loops is still far from being solved. We propose DaReUS-Loop, a data-based approach that identifies loop candidates mining the complete set of experimental structures available in the Protein Data Bank. Candidate filtering relies on local conformation profile-profile comparison, together with physico-chemical scoring. Applied to three different template-based test sets, DaReUS-Loop shows significant increase in the number of high-accuracy loops, and significant enhancement for modeling long loops. A special advantage is that our method proposes a prediction confidence score that correlates well with the expected accuracy of the loops. Strikingly, over 50% of successful loop models are derived from unrelated proteins, indicating that fragments under similar constraints tend to adopt similar structure, beyond mere homology.
Histone acetylation as a new mechanism for bilirubin-induced encephalopathy in the Gunn rat
Authors: Vianello Eleonora , Zampieri Stefania , Marcuzzo Thomas , Tordini Fabio , Bottin Cristina , Dardis Andrea , Zanconati Fabrizio , Tiribelli Claudio , Gazzin Silvia 
Published: September 2018

AbstractBilirubin neurotoxicity has been studied for decades and has been shown to affect various mechanisms via significant modulation of gene expression. This suggests that vital regulatory mechanisms of gene expression, such as epigenetic mechanisms, could play a role in bilirubin neurotoxicity. Histone acetylation has recently received attention in the CNS due to its role in gene modulation for numerous biological processes, such as synaptic plasticity, learning, memory, development and differentiation. Aberrant epigenetic regulation of gene expression in psychiatric and neurodegenerative disorders has also been described. In this work, we followed the levels of histone 3 lysine 14 acetylation (H3K14Ac) in the cerebellum (Cll) of the developing (2, 9, 17 days after the birth) and adult Gunn rat, the natural model for neonatal hyperbilirubinemia and kernicterus. We observed an age-specific alteration of the H3K14Ac in the hyperbilirubinemic animals. The GeneOntology analysis of the H3K14Ac linked chromatin revealed that almost 45% of H3K14Ac ChiP-Seq TSS-promoter genes were involved in CNS development including maturation and differentiation, morphogenesis, dendritogenesis, and migration. These data suggest that the hallmark Cll hypoplasia in the Gunn rat occurs also via epigenetically controlled mechanisms during the maturation of this brain structure, unraveling a novel aspect of the bilirubin-induced neurotoxicity.
HD 189733 b: bow shock or no shock?
Authors: Kohl S. , Salz M. , Czesla S. , Schmitt J. H. M. M. 
Published: September 2018

Context. Hot Jupiters are surrounded by extended atmospheres of neutral hydrogen. Observations have provided evidence for in-transit hydrogen Hα absorption as well as variable pre-transit absorption signals. These have been interpreted in terms of a bow shock or an accretion stream that transits the host star before the planet.
Aims. We test the hypothesis of planetary-related Hα absorption by studying the time variability of the Hα and stellar activity-sensitive calcium lines in high-resolution TIGRE (Telescopio Internacional de Guanajuato Robótico Espectroscópico) spectra of the planet host HD 189733.
Methods. In the framework of an observing campaign spanning several months, the host star was observed several times per week randomly sampling the orbital phases of the planet. We determine the equivalent width in the Hα and Ca IRT(calcium infrared triplet) lines, and subtract stellar rotationally induced activity from the Hα time series via its correlation with the IRT evolution. The residuals are explored for significant differences between the pre-, in-, and out-of-transit phases.
Results. We find strong stellar rotational variation with a lifetime of about 20–30 days in all activity indicators, but the corrected Hα time series exhibits no significant periodic variation. We exclude the presence of more than 6.2 mÅ pre-transit absorption and 5.6 mÅ in-transit absorption in the corrected Hα data at a 99% confidence level.
Conclusions. Previously observed Hα absorption signals exceed our upper limits, but they could be related to excited atmospheric states. The Hα variability in the HD 189733 system is dominated by stellar activity, and observed signals around the planetary transit may well be caused by short-term stellar variability.
Fetal Skeletal Disorders
Authors: Schramm Thomas , Mommsen Helge 
Published: September 2018

AbstractSkeletal disorders of the fetus are quite common. The incidence is about 5:1000 pregnancies. The disorders affect the extremities or parts of them (dysmelia), the whole skeleton (skeletal dysplasia), the skull (craniosynostosis) and the spine (dysostosis, caudal regression). About half of these diseases are complex. In the majority of cases the complex disorders are caused by single gene mutations or numeric or structural chromosomal aberrations. We explain the classification and diagnostic criteria for prenatal expert and screening ultrasound based on frequent disorders. The main diagnostic challenge concerning malformations of the limbs and craniosynostosis is to find out if they are isolated or symptoms of certain syndromes. In skeletal dysplasia it is clinically important to differentiate lethal entities from non-lethal.
A Governance Model Addressing the Challenges of Contemporary Research
Authors: Downes Linda , Teede Helena , Norman Robert , Garad Rhonda 
Published: September 2018

AbstractIn this paper, we describe the robust governance structures and processes underpinning the development of the first International Evidence-Based Guideline for the Assessment and Management Polycystic Ovary Syndrome (2018). The guideline was an outcome of the Centre of Research Excellence for Polycystic Ovary Syndrome, and an example of a transformative, strategic research initiative to impact delivery model. The governance structure supported and delivered critical ethical and regulatory outcomes, including: broad and diverse representation across health professional and consumer groups and exceeded regulatory standards; adherence to rigorous knowledge creation processes; and compliance with the standards for guidelines set by the approval body, the Australian National Health and Medical Research Council (NHMRC). Well-articulated and appropriately implemented governance structures that meet the complex nature of contemporary research and translation activities are essential to enable distributed leadership and to deliver key outcomes.
Application of Monash Centre for Health Research and Implementation Framework to the Development of Polycycstic Ovary Syndrome Guideline: A Case Study on Implementation
Authors: Skouteris Helen , Melder Angela , Bailey Cate , Morris Heather , Garad Rhonda , Teede Helena , Robinson Tracy 
Published: September 2018

AbstractImplementation of healthcare guidelines, a set of recommendations aiming to optimize patient care, can be a complex process which is at risk of poor translation into practice. Failure to adopt new evidence-based healthcare findings can contribute to a large variation in care, potentially affecting outcomes for service users. Designed to avoid this issue, the Monash Centre for Health Research and Implementation (MCHRI) knowledge translation framework was created to support the development and future implementation of clinical practice guidelines. The framework is distinguished by a focus on methodological rigor, stakeholder engagement, and partnership, leading to the coproduction of a guideline and research projects. In this article, we use the development of the International Evidence-based Guideline on the Assessment and Management of Polycystic Ovarian Syndrome (2018) as a case study to articulate the MCHRI knowledge translation framework. Specifically, this article discusses stakeholder engagement; development and codesign of evidence-based recommendations; implementation and knowledge generation; dissemination, translation, and scale up; and refinement/learning from evaluation. This case study demonstrates how hybrid frameworks, models, and theories for implementation, such as the MCHRI implementation framework, have their place in healthcare. The underlying principle that informs the framework is stakeholder engagement, including codesign, empowerment, and partnership.
Bladder Outlet Obstruction as a Cause for Late Total Flap Failure in Pelvic Reconstruction with a VRAM
Authors: Stein Michael , Momtazi Moein 
Published: September 2018

Background A 67-year-old man presented with abrupt failure of a pedicled vertical rectus abdominus myocutaneous (VRAM) flap 13 days postoperatively.
Methods The patient underwent pelvic reconstruction with a pedicled VRAM flap following sacral chordoma and abdominoperineal resection. The flap remained well perfused and viable until postoperative day 13, at which point the patient was noted to become systemically unwell with fever, chills, and abdominal pain. This clinically coincided with prompt arterial and venous insufficiency of the VRAM flap.
Results Computed tomography of the abdomen was ordered to rule out a pelvic collection and revealed an inflated Foley catheter in the bulbar urethra. This was associated with marked distention of the bladder and bilateral hydronephrosis. Direct compression of the deep inferior epigastric pedicle by the bladder neck was noted.
Conclusion The case highlights the importance of considering bladder outlet obstruction and subsequent distention as a cause of pedicle compression and VRAM flap failure following pelvic reconstruction.
Die gesundheitliche Versorgung von wohnungslosen Menschen mit psychischen Problemen
Authors: Franz M. , Salize H.-J. , Hoell A. 
Published: September 2018

Zusammenfassung
Hintergrund: Wohnungslosigkeit ist ein vielerorts kaum zu übersehendes und trotzdem gesamtgesellschaftlich weitgehend ignoriertes Phänomen. Menschen mit psychischen Problemen und bestehender Abhängigkeitserkrankung finden sich überzufällig häufig in der Gruppe Wohnungsloser. Methode: Eine internationale systematische Literaturrecherche wurde mit einer deutschsprachigen Recherche in der Datenbank des Netzwerkes für Versorgungsforschung kombiniert, um aktuelle Ergebnisse von Interventionen für Wohnungslose mit psychischen Erkrankungen darzustellen. Ergebnisse: Insbesondere im anglo-amerikanischen Sprachraum werden viele gemeindenahe Ansätze wie Housing First und Assertive Community Treatment beschrieben, die gute Ergebnisse für Wohnstabilität und Lebenszufriedenheit zeigen. Gemischt sind die Ergebnisse für die psychische Gesundheit. Forschung im deutschsprachigen Raum ist vergleichsweise defizitär. Ausblick: Niedrigschwellige oder aufsuchende Angebote scheinen vorteilhaft zu sein. Doch die Befunde lassen sich aufgrund sozialrechtlicher Unterschiede nicht per se auf die hiesigen Gegebenheiten übertragen. Das Problem wird gegenwärtig durch den sozialstrukturellen Wandel mit dem Aufkommen Geflüchteter verschärft.
The impact of economic crisis on mental and physical health in Italy
Authors: Tomassi S. , Ruggeri M. 
Published: September 2018

Summary
Background: The global crisis that began in 2007 has been the most prolonged economic recession since 1929. It has caused worldwide tangible costs in terms of cuts in employment and income, which have been widely recognised also as major social determinants of mental health (1, 2). The so-called “Great Recession” has disproportionately affected the most vulnerable part of society of the whole Eurozone (3). Across Europe, an increase in suicides and deaths rates due to mental and behavioural disorders was reported among those who lost their jobs, houses and economic activities as a consequence of the crisis.
Stationäre Psychotherapie der Depression: Kliniken, Leitlinien, Methoden und Herausforderungen
Authors: Nisch C. , Tauber R. F. , Himmerich H. 
Published: September 2018

ZusammenfassungStationäre Depressionstherapie findet in Deutschland in krankenversicherungsfinanzierten psychiatrisch-psychotherapeutischen oder psychosomatisch-psychotherapeutischen Akutkliniken und in rentenversicherungsfinanzierten Rehabilitationskliniken statt. In Akutkliniken wird die Diagnose nach der Internationalen Klassifikation der Krankheiten (ICD) gestellt und therapeutisch versucht, eine Remission zu erreichen; häufig sind eine spezialisierte Depressionsstation und ein klinikinterner Behandlungsalgorithmus vorhanden. In Rehabilitationskliniken spielt diagnostisch das Modell der internationalen Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit (ICF) eine wesentliche Rolle; seitens der Deutschen Rentenversicherung wurde ein Reha-Therapiestandard für depressive Störungen entwickelt. Als störungsspezifische Psychotherapieformen empfehlen sich neben der Kognitiven Verhaltenstherapie (KVT) und anderen Richtlinienverfahren für bestimmte Patienten Schematherapie oder Cognitive Behavioral Analysis System of Psychotherapy (CBASP). Das Behandlungsangebot kann außerdem die Therapie mit Antidepressiva, indikative Gruppen bei Komorbidität, Fertigkeitentraining und Psychoedukation sowie Ergo-, Physio-, Bewegungsund Musiktherapie, Sozialarbeit, Angehörigenarbeit und Selbsthilfegruppen umfassen.
Pharmakotherapie der Depression in Schwangerschaft und Stillzeit
Authors: Kittel-Schneider S. 
Published: September 2018

ZusammenfassungDepressive Episoden sind ein ebenso häufiges Problem in der Schwangerschaft und Stillzeit wie in anderen Lebensabschnitten bei Frauen. Insbesondere bei schwer ausgeprägter Symptomatik kann auch in dieser besonderen Lebensspanne eine psychopharmakologische Therapie indiziert sein. Dies sollte allerdings immer nach individuellem Nutzen-Risiko entschieden werden gemeinsam mit der Patienten und ggf. auch dem Partner. Große neuere Studien zeigen nach Adjustierung für verschiedene Risikofaktoren, dass die meisten Antidepressiva und Antipsychotika auch wenn sie im ersten Trimenon der Schwangerschaft gegeben werden, kein erhöhtes Risiko für Fehlbildungen haben. Medikation mit SSRIs im letzten Trimenon der Schwangerschaft wurde in mehreren Studien als assoziiert mit einem erhöhten Risiko für die an sich sehr seltene, aber potenziell schwerwiegende Komplikation des persistierenden pulmonalen Hypertonus gezeigt (PPH). Die in Zusammenhang mit SSRI-Exposition berichteten PPH-Fälle endeten jedoch nicht tödlich, wie das bei PPH aus anderer Ursache potenziell vorkommen kann. Antidepressiva und Antipsychotika-Gabe in der Spätschwangerschaft sind allerdings in bis zu 30% der Kinder mit so genannten Anpassungsstörungen assoziiert. Diese äußern sich z.B. in Tremor, Trinkschwäche und Apathie, sind aber in der Regel nicht lebensbedrohlich und selbstlimitierend. Weniger gut ist die Datenlage bezüglich Medikamenteneinnahme in der Stillzeit. Einige Substanzen können aber als relativ sicher für das gestillte Kind angesehen werden. Sertralin, Paroxetin und Nortriptylin sind aktuell die Substanzen mit der besten Datenlage unter den Antidepressiva. Bei den Antipsychotika sind Olanzapin und Quetiapin die Mittel der ersten Wahl in der Stillzeit.
Alternative und unterstützende Verfahren in der Depressionsbehandlung – Sport und Bewegung
Authors: Hänsel F. , Oertel-Knöchel V. 
Published: September 2018

ZusammenfassungHauptsymptome depressiver Erkrankungen sind eine gedrückte Stimmung, eine Reduktion des Antriebs, Interessenverlust und kognitive Einschränkungen wie eine Verminderung der Aufmerksamkeitsleistung und der Konzentrationsfähigkeit. Viele depressive Patienten berichten darüber hinaus über Appetitstörungen, Schlafstörungen und Energielosigkeit. Diese können in der Folge zu Aktivitätseinschränkungen und körperliche Inaktivität führen. Davon betroffen sind meist auch die sozialen Interaktionen der Patienten und es kommt zu sozialem Rückzug. Daraus resultiert vielfach eine eingeschränkte Funktionalität sowohl im Alltag als auch im Berufsleben. Körperliche Aktivität hat neben einer Vielzahl positiver metabolischer Effekte einen neuroprotektiven Effekt, indem es die Neurogenese anstößt. Darüber hinaus steigert regelmäßige Bewegung die Lebensqualität bei chronisch psychiatrischen Patienten und reduziert Aggressionen sowie Suizidalität. Weiterhin konnten ein gestärktes Selbstbewusstsein, ein positives Selbstbild, weniger negative Grundüberzeugungen, verbesserte Handlungskompetenzen und der Aufbau von intrinsischer Motivation gezeigt werden. Insgesamt zeigt sich, dass die Wirksamkeit sportlichen Trainings, insbesondere in Bezug auf die Größe des Effekts trotz vieler Studien aufgrund von methodischen Verzerrungen unklar bleibt. Zweitens ist die Frage nach potenziellen Mechanismen eines antidepressiven Effekts sportlichen Trainings bisher nicht ausreichend geklärt (Wirkung).
Postpartale psychische Erkrankungen
Authors: Hornstein C. , Trautmann-Villalba P. 
Published: September 2018

ZusammenfassungDie Mutterschaft und die Beziehung zum Kind prägen das klinische Bild postpartaler psychischer Erkrankungen. Die Defizite der Mutter-Kind-Beziehung können die affektive und kognitive Entwicklung des Kindes nachhaltig negativ beeinflussen, sie verbessern sich nicht allein durch die erfolgreiche psychiatrische Behandlung der mütterlichen Störung. In der Therapie sollten daher neben der störungsspezifischen psychiatrisch- psychotherapeutischen Behandlung die Auseinandersetzung mit der Mutterrolle sowie der Aufbau und die Unterstützung der Mutter-Kind-Beziehung weitere Schwerpunkte sein. Väter spielen eine entscheidende Rolle im mütterlichen Genesungsprozess und können den Kindern wichtige kompensierende Erfahrungen anbieten. Auch sie können unter psychischen Belastungen leiden, insbesondere dann, wenn die Mutter erkrankt ist. Die therapeutische Erreichbarkeit psychisch erkrankter Eltern in der Postpartalzeit hat in den letzten Jahren in Deutschland deutlich zugenommen, ebenso wie die Anzahl differenzierter Versorgungskonzepte und -möglichkeiten.