bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micromechanical Behavior of DNA‐1A Lunar Regolith Simulant in Comparison to Ottawa Sand
Authors: Sandeep C. S. , Marzulli V. , Cafaro F. , Senetakis K. , Pöschel T. 
Published: August 2019

AbstractIn this study, the micromechanical interparticle contact behavior of “De NoArtri” (DNA‐1A) grains is investigated, which is a lunar regolith simulant, using a custom‐built micromechanical loading apparatus, and the results on the DNA‐1A are compared with Ottawa sand which is a standard quartz soil. Material characterization is performed through several techniques. Based on microhardness intender and surface profiler analyses, it was found that the DNA‐1A grains had lower values of hardness and higher values of surface roughness compared to Ottawa sand grains. In normal contact micromechanical tests, the results showed that the DNA‐1A had softer behavior compared with Ottawa sand grains and that cumulative plastic displacements were observed for the DNA‐1A simulant during cyclic compression, whereas for Ottawa sand grains elastic displacements were dominant in the cyclic sequences. In tangential contact micromechanical tests, it was shown that the interparticle friction values of DNA‐1A were much greater than that of Ottawa sand grains, which was attributed to the softer contact response and greater roughness of the DNA‐1A grains. Widely used theoretical models both in normal and tangential directions were fitted to the experimental data to obtain representative parameters, which can be useful as input in numerical analyses which use the discrete element method.
Controlling Anthropogenic and Natural Seismicity: Insights From Active Stabilization of the Spring‐Slider Model
Authors: Stefanou Ioannis 
Published: August 2019

AbstractWe present a theoretical study focusing on exploring the possibility of controlling anthropogenic and natural seismicity. We actively control the pressure of injected fluids using a negative‐feedback control system. Our analysis is based on the spring‐slider model for modeling the earthquake instability. We use a general Coulomb‐type rheology for describing the frictional behavior of a fault system. This model leads to a nonautonomous system, whose steady state and stability are studied using a double‐scale asymptotic analysis. This approach renders the dominant order of the system time invariant. Established tools from the classical mathematical theory of control are used for designing a proper stabilizing controller. We show that the system is stabilizable by controlling fluid pressure. This is a central result for industrial operations. A stabilizing controller is then designed and tested. The controller regulates in real time the applied pressure in order to assure stability, avoid unwanted seismicity, and drive the system from unstable states of high potential energy, to stable ones of low energy. The controller performs well even in the absence of complete knowledge of the frictional properties of the system. Finally, we present two numerical examples (scenarios) and illustrate how anthropogenic and natural earthquakes could be, in theory, prevented.
Core‐Mantle Boundary Dynamic Topography: Influence of Postperovskite Viscosity
Authors: Deschamps Frédéric , Li Yang 
Published: August 2019

AbstractCore‐mantle boundary (CMB) topography may provide useful hints on the deep mantle thermochemical structure, as clusters of thermal plumes and piles of chemically differentiated material, which are usually proposed as end‐member explanations for the large low shear‐wave velocity regions observed in the deep mantle, have different actions on this topography. CMB topography is further sensitive to several parameters, including mantle viscosity and its variations with thermal and compositional changes. Here we assess the influence of the postperovskite (pPv) phase viscosity on deep mantle dynamics and on CMB topography. We perform numerical simulations of thermal and thermochemical convection in spherical geometry, varying the ratio between pPv and bridgmanite viscosities, ΔηpPv, between 1 (regular pPv) and 10−3 (weak pPv). Thermochemical structures are dominated by smaller‐scale wavelengths (spherical harmonic degrees 3 to 6) and are more stable in weak than in regular pPv models. The amplitude of CMB topography is reduced by about a factor of 2 as ΔηpPv changes from 1 to 10−3, mostly due to a sharp drop in the depressions induced by downwellings reaching the CMB. By contrast, the topographies induced by plumes clusters and thermochemical piles are mostly unaffected. For all the values of ΔηpPv we tested, long‐wavelength CMB topography and reconstructed shear‐wave tomography are anticorrelated in purely thermal models, and correlated in thermochemical models with strong chemical density contrast (ΔρC = 140 kg/m3). In models with smaller density contrast (ΔρC = 90 kg/m3), topography and tomography are anticorrelated at ΔηpPv = 1, but correlated at ΔηpPv = 10−3.
The Summertime Precipitation Bias in E3SM Atmosphere Model Version 1 over the Central United States
Authors: Zheng X. , Golaz J.‐C. , Xie S. , Tang Q. , Lin W. , Zhang M. , Ma H.‐Y. , Roesler E. L. 
Published: August 2019

AbstractThis study analyzes the summertime precipitation bias over the Central United States and its relationship to the simulated large‐scale environment and the convection scheme in the Energy Exascale Earth System Model Atmosphere Model version 1. This relationship is mainly examined in a set of short‐term hindcasts initialized with realistic large‐scale conditions for the summer of 2011. Besides the uniform 1° model resolution, we adopt Regionally Refined Meshes to increase the model resolution to 0.25° over the contiguous United States. Additional five‐year Atmospheric Model Intercomparison Project simulations are conducted to confirm that the results from the hindcasts are consistent with the climate runs. We find that the summertime dry precipitation bias over the Great Plains and the wet bias over the Rockies cannot be reduced simultaneously by changing resolution or tuning parameters. As for the diurnal cycle, Energy Exascale Earth System Model Atmosphere Model version 1 captures the general diurnal variation of the large‐scale moisture transport and the large‐scale upward motion over the Central United States. However, the diurnal cycle of precipitation over the Great Plains is out of phase with the diurnal variation of the large‐scale environment because the convective precipitation dominates the total precipitation and its diurnal cycle, and it does not directly respond to the local moisture convergence and the large‐scale upward motion. These results reemphasize the importance of improving the coupling of the convection to the large‐scale environment in reducing the summer precipitation bias over the Central United States in climate models with the resolution of ~0.25°.
Production of seedable Amyloid-β peptides in model of prion diseases upon PrPSc-induced PDK1 overactivation
Authors: Ezpeleta Juliette , Baudouin Vincent , Arellano-Anaya Zaira E. , Boudet-Devaud François , Pietri Mathéa , Baudry Anne , Haeberlé Anne-Marie , Bailly Yannick , Kellermann Odile , Launay Jean-Marie , Schneider Benoit 
Published: August 2019

AbstractThe presence of amyloid beta (Aβ) plaques in the brain of some individuals with Creutzfeldt-Jakob or Gertsmann-Straussler-Scheinker diseases suggests that pathogenic prions (PrPSc) would have stimulated the production and deposition of Aβ peptides. We here show in prion-infected neurons and mice that deregulation of the PDK1-TACE α-secretase pathway reduces the Amyloid Precursor Protein (APP) α-cleavage in favor of APP β-processing, leading to Aβ40/42 accumulation. Aβ predominates as monomers, but is also found as trimers and tetramers. Prion-induced Aβ peptides do not affect prion replication and infectivity, but display seedable properties as they can deposit in the mouse brain only when seeds of Aβ trimers are co-transmitted with PrPSc. Importantly, brain Aβ deposition accelerates death of prion-infected mice. Our data stress that PrPSc, through deregulation of the PDK1-TACE-APP pathway, provokes the accumulation of Aβ, a prerequisite for the onset of an Aβ seeds-induced Aβ pathology within a prion-infectious context.
Split spawning increases robustness of coral larval supply and inter-reef connectivity
Authors: Hock Karlo , Doropoulos Christopher , Gorton Rebecca , Condie Scott A. , Mumby Peter J. 
Published: August 2019

AbstractMany habitat-building corals undergo mass synchronous spawning events. Yet, despite the enormous amounts of larvae produced, larval dispersal from a single spawning event and the reliability of larval supply are highly dependent on vagaries of ocean currents. However, colonies from the same population will occasionally spawn over successive months. These split spawning events likely help to realign reproduction events to favourable environmental conditions. Here, we show that split spawning may benefit corals by increasing the reliability of larval supply. By modelling the dispersal of coral larvae across Australia’s Great Barrier Reef, we find that split spawning increased the diversity of sources and reliability of larval supply the reefs could receive, especially in regions with low and intrinsically variable connectivity. Such increased larval supply might help counteract the expected declines in reproductive success associated with split spawning events.
A biomimetic 2D transistor for audiomorphic computing
Authors: Das Sarbashis , Dodda Akhil , Das Saptarshi 
Published: August 2019

AbstractIn this article, we introduce a biomimetic audiomorphic device that captures the neurobiological architecture and computational map inside the auditory cortex of barn owl known for its exceptional hunting ability in complete darkness using auditory cues. The device consists of multiple split-gates with nanogaps on a semiconducting MoS2 channel connected to the source/drain contacts for imitating the spatial map of coincidence detector neurons and tunable RC circuits for imitating the interaural time delay neurons following the Jeffress model of sound localization. Furthermore, we use global back-gating capability to demonstrate neuroplasticity to capture behavioral and/or adaptation related changes in the barn owl. Finally, the virtual source model for current transport is combined with finite element COMSOL multiphysics simulations to explain and project the performance of the biomimetic audiomorphic device. We find that the precision of the biomimetic device can supersede the barn owl by orders of magnitude.
Expansion of a core regulon by transposable elements promotes Arabidopsis chemical diversity and pathogen defense
Authors: Barco Brenden , Kim Yoseph , Clay Nicole K. 
Published: August 2019

AbstractPlants synthesize numerous ecologically specialized, lineage-specific metabolites through biosynthetic gene duplication and functional specialization. However, it remains unclear how duplicated genes are wired into existing regulatory networks. We show that the duplicated gene CYP82C2 has been recruited into the WRKY33 regulon and indole-3-carbonylnitrile (ICN) biosynthetic pathway through exaptation of a retroduplicated LINE retrotransposon (EPCOT3) into an enhancer. The stepwise development of a chromatin-accessible WRKY33-binding site on EPCOT3 has potentiated the regulatory neofunctionalization of CYP82C2 and the evolution of inducible defense metabolite 4-hydroxy-ICN in Arabidopsis thaliana. Although transposable elements (TEs) have long been recognized to have the potential to rewire regulatory networks, these results establish a more complete understanding of how duplicated genes and TEs contribute in concert to chemical diversity and pathogen defense.
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis
Authors: Collins Stephan C. , Mikhaleva Anna , Vrcelj Katarina , Vancollie Valerie E. , Wagner Christel , Demeure Nestor , Whitley Helen , Kannan Meghna , Balz Rebecca , Anthony Lauren F. E. , Edwards Andrew , Moine Hervé , White Jacqueline K. , Adams David J. , Reymond Alexandre , Lelliott Christopher J. , Webber Caleb , Yalcin Binnaz 
Published: August 2019

AbstractBrain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here we analyze 118 neuroanatomical parameters in 1,566 mutant mouse lines and identify 198 genes whose disruptions yield NeuroAnatomical Phenotypes (NAPs), mostly affecting structures implicated in brain connectivity. Groups of functionally similar NAP genes participate in pathways involving the cytoskeleton, the cell cycle and the synapse, display distinct fetal and postnatal brain expression dynamics and importantly, their disruption can yield convergent phenotypic patterns. 17% of human unique orthologues of mouse NAP genes are known loci for cognitive dysfunction. The remaining 83% constitute a vast pool of genes newly implicated in brain architecture, providing the largest study of mouse NAP genes and pathways. This offers a complementary resource to human genetic studies and predict that many more genes could be involved in mammalian brain morphogenesis.
Automatic and feature-specific prediction-related neural activity in the human auditory system
Authors: Demarchi Gianpaolo , Sanchez Gaëtan , Weisz Nathan 
Published: August 2019

AbstractPrior experience enables the formation of expectations of upcoming sensory events. However, in the auditory modality, it is not known whether prediction-related neural signals carry feature-specific information. Here, using magnetoencephalography (MEG), we examined whether predictions of future auditory stimuli carry tonotopic specific information. Participants passively listened to sound sequences of four carrier frequencies (tones) with a fixed presentation rate, ensuring strong temporal expectations of when the next stimulus would occur. Expectation of which frequency would occur was parametrically modulated across the sequences, and sounds were occasionally omitted. We show that increasing the regularity of the sequence boosts carrier-frequency-specific neural activity patterns during both the anticipatory and omission periods, indicating that prediction-related neural activity is indeed feature-specific. Our results illustrate that even without bottom-up input, auditory predictions can activate tonotopically specific templates.
Heavy screen users are the heaviest among 10,000 children
Authors: Engberg Elina , Figueiredo Rejane A. O. , Rounge Trine B. , Weiderpass Elisabete , Viljakainen Heli 
Published: August 2019

AbstractThis cross-sectional study examined the associations of recreational screen time (viewing TV programs on any screen-based device and computer use, performed while sitting) with body mass index (BMI) categories and waist-to-height ratio (WHtR) tertiles in 10,228 children (mean age 11.1 years, SD 0.8). We categorized the children into Light, Medium and Heavy TV viewers and computer users, and into Low, Medium and High exercise groups. Compared with Light TV viewers, Medium (OR: 1.30, 95% CI: 1.11–1.52, when adjusted for age, sex, language, sleep duration and exercise) and Heavy (OR: 1.57, 95% CI: 1.34–1.83) TV viewers had a higher risk of being overweight. Similarly, Heavy computer users had a higher risk of being overweight (OR: 1.42, 95% CI: 1.21–1.67). We observed interactions between exercise and TV viewing (p = 0.012) or computer use (p = 0.010). However, Heavy TV viewers had a higher risk of being overweight in all exercise groups. The associations of TV viewing and computer use were similar with BMI and WHtR. To conclude, heavy sedentary screen time is associated with overweight and central adiposity in children. Moreover, heavy TV viewers have a higher risk for overweight and central adiposity, regardless of weekly exercise duration.
Individual diversity between interdependent networks promotes the evolution of cooperation by means of mixed coupling
Authors: Liu Sicheng , Zhang Lin , Wang Baokui 
Published: August 2019

AbstractAlong with the rapid development of network-based information technology, such as cloud computing, big data, the IoT, and so on, human society has stepped into a new era of complex networks. People’s life and production activities depend more and more on various complex networks to ensure security and reliability. The complex interrelationships between human and nature establish a link to explain the cooperation of individual behaviour, especially for individual diversity. However, existing researches mostly ignore the influence of individual diversity on networks involved in individual behaviour to strategy selection. Therefore, it needs further research on how to consider both individual diversity and independent networks in the evolution of cooperative behaviour. To address this issue, we extend a simple game model into the interdependent networks through the mixed coupling (i.e., utility and probability) in this work. Also, we divide the kinds of strategic behaviour of a player in one layer concerning individual diversity. Moreover, there exists an optimal region of mixed coupling between networks such that cooperation can be promoted. Finally, experimental results can open the path to understanding the emergence and maintenance of cooperation within various interconnected and interrelated real-world systems newly.
Genome-wide screening of mouse knockouts reveals novel genes required for normal integumentary and oculocutaneous structure and function
Authors: Moore Bret A. , Flenniken Ann M. , Clary Dave , Moshiri Ata S. , Nutter Lauryl M. J. , Berberovic Zorana , Owen Celeste , Newbigging Susan , Adissu Hibret , Eskandarian Mohammad , McKerlie Colin ,   International Mouse Phenotyping Consortium, Brown Steve , Wells Sara , Mallon Ann-Marie , Beaudet Arthur L. , de Angelis Martin Hrabe , Karp Natasha , Braun Bob , Herault Yann , Gao Xiang , Obata Yuichi , Flicek Paul , Meehan Terrence , Parkinson Helen , Smedley Damian , Seong J. K. , Tocchini-Valentini Glauco , Mammano Fabio , Thomasy Sara M. , Lloyd K. C. Kent , Murphy Christopher J. , Moshiri Ala 
Published: August 2019

AbstractOculocutaneous syndromes are often due to mutations in single genes. In some cases, mouse models for these diseases exist in spontaneously occurring mutations, or in mice resulting from forward mutatagenesis screens. Here we present novel genes that may be causative for oculocutaneous disease in humans, discovered as part of a genome-wide screen of knockout-mice in a targeted single-gene deletion project. The International Mouse Phenotyping Consortium (IMPC) database (data release 10.0) was interrogated for all mouse strains with integument abnormalities, which were then cross-referenced individually to identify knockouts with concomitant ocular abnormalities attributed to the same targeted gene deletion. The search yielded 307 knockout strains from unique genes with integument abnormalities, 226 of which have not been previously associated with oculocutaneous conditions. Of the 307 knockout strains with integument abnormalities, 52 were determined to have ocular changes attributed to the targeted deletion, 35 of which represent novel oculocutaneous genes. Some examples of various integument abnormalities are shown, as well as two examples of knockout strains with oculocutaneous phenotypes. Each of the novel genes provided here are potentially relevant to the pathophysiology of human integumentary, or oculocutaneous conditions, such as albinism, phakomatoses, or other multi-system syndromes. The novel genes reported here may implicate molecular pathways relevant to these human diseases and may contribute to the discovery of novel therapeutic targets.
Sputtered Porous Li-Fe-P-O Film Cathodes Prepared by Radio Frequency Sputtering for Li-ion Microbatteries
Authors: Sugiawati V. A. , Vacandio F. , Perrin-Pellegrino C. , Galeyeva A. , Kurbatov A. P. , Djenizian T. 
Published: August 2019

AbstractThe increasing demands from micro-power applications call for the development of the electrode materials for Li-ion microbatteries using thin-film technology. Porous Olivine-type LiFePO4 (LFP) and NASICON-type Li3Fe2(PO4)3 have been successfully fabricated by radio frequency (RF) sputtering and post-annealing treatments of LFP thin films. The microstructures of the LFP films were characterized by X-ray diffraction and scanning electron microscopy. The electrochemical performances of the LFP films were evaluated by cyclic voltammetry and galvanostatic charge-discharge measurements. The deposited and annealed thin film electrodes were tested as cathodes for Li-ion microbatteries. It was found that the electrochemical performance of the deposited films depends strongly on the annealing temperature. The films annealed at 500 °C showed an operating voltage of the porous LFP film about 3.45 V vs. Li/Li+ with an areal capacity of 17.9 µAh cm−2 µm−1 at C/5 rate after 100 cycles. Porous NASICON-type Li3Fe2(PO4)3 obtained after annealing at 700 °C delivers the most stable capacity of 22.1 µAh cm−2 µm−1 over 100 cycles at C/5 rate, with an operating voltage of 2.8 V vs. Li/Li+. The post-annealing treatment of sputtered LFP at 700 °C showed a drastic increase in the electrochemical reactivity of the thin film cathodes vs. Li+, leading to areal capacity ~9 times higher than as-deposited film (~27 vs. ~3 µAh cm−2 µm−1) at C/10 rate.
Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathway
Authors: Halder Vivek , Suliman Mohamed N. S. , Kaschani Farnusch , Kaiser Markus 
Published: August 2019

AbstractIn plants, low-dose of exogenous bacterial cyclic lipopeptides (CLPs) trigger transient membrane changes leading to activation of early and late defence responses. Here, a forward chemical genetics approach identifies colistin sulphate (CS) CLP as a novel plant defence inducer. CS uniquely triggers activation of the PATHOGENESIS-RELATED 1 (PR1) gene and resistance against Pseudomonas syringae pv. tomato DC3000 (Pst DC3000) in Arabidopsis thaliana (Arabidopsis) independently of the PR1 classical inducer, salicylic acid (SA) and the key SA-signalling protein, NON-EXPRESSOR OF PR1 (NPR1). Low bioactive concentration of CS does not trigger activation of early defence markers such as reactive oxygen species (ROS) and mitogen activated protein kinase (MAPK). However, it strongly suppresses primary root length elongation. Structure activity relationship (SAR) assays and mode-of-action (MoA) studies show the acyl chain and activation of a ∼46 kDa p38-like kinase pathway to be crucial for CS’ bioactivity. Selective pharmacological inhibition of the active p38-like kinase pathway by SB203580 reverses CS’ effects on PR1 activation and root length suppression. Our results with CS as a chemical probe highlight the existence of a novel SA- and NPR1-independent branch of PR1 activation functioning via a membrane-sensitive p38-like kinase pathway.