bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway
Authors: Elia Lisa P. , Mason Amanda R. , Alijagic Amela , Finkbeiner Steven 
Published: January 2019

Deficient progranulin levels cause dose-dependent neurological syndromes: haploinsufficiency leads to frontotemporal lobar degeneration (FTLD) and nullizygosity produces adult-onset neuronal ceroid lipofuscinosis. Mechanisms controlling progranulin levels are largely unknown. To better understand progranulin regulation, we performed a genome-wide RNAi screen using an ELISA-based platform to discover genes that regulate progranulin levels in neurons. We identified 830 genes that raise or lower progranulin levels by at least 1.5-fold in Neuro2a cells. When inhibited by siRNA or some by submicromolar concentrations of small-molecule inhibitors, 33 genes of the druggable genome increased progranulin levels in mouse primary cortical neurons; several of these also raised progranulin levels in FTLD model mouse neurons. “Hit” genes regulated progranulin by transcriptional or posttranscriptional mechanisms. Pathway analysis revealed enrichment of hit genes from the autophagy–lysosome pathway (ALP), suggesting a key role for this pathway in regulating progranulin levels. Progranulin itself regulates lysosome function. We found progranulin deficiency in neurons increased autophagy and caused abnormally enlarged lysosomes and boosting progranulin levels restored autophagy and lysosome size to control levels. Our data link the ALP to neuronal progranulin: progranulin levels are regulated by autophagy and, in turn, progranulin regulates the ALP. Restoring progranulin levels by targeting genetic modifiers reversed FTLD functional deficits, opening up potential opportunities for future therapeutics development.SIGNIFICANCE STATEMENTProgranulin regulates neuron and immune functions and is implicated in aging. Loss of one functional allele causes haploinsufficiency and leads to frontotemporal lobar degeneration (FTLD), the second leading cause of dementia. Progranulin gene polymorphisms are linked to Alzheimer's disease (AD) and complete loss of function causes neuronal ceroid lipofuscinosis. Despite the critical role of progranulin levels in neurodegenerative disease risk, almost nothing is known about their regulation. We performed an unbiased screen and identified specific pathways controlling progranulin levels in neurons. Modulation of these pathways restored levels in progranulin-deficient neurons and reversed FTLD phenotypes. We provide a new comprehensive understanding of the genetic regulation of progranulin levels and identify potential targets to treat FTLD and other neurodegenerative diseases, including AD.
La gestión integral como una herramienta de la productividad
Authors: Rodríguez Rojas Yuber Liliana 
Published: January 2019

La gestión implica caminos lógicos en pro de la búsqueda de soluciones creativas ante los problemas de los procesos y la administración de la organización. Por lo cual, es indispensable contar con la participación de la alta dirección en la apropiación, por parte de la organización, de los sistemas de gestión basados en normas técnicas internacionales, entre ellos: calidad, ambiental, seguridad y salud en el trabajo como parte de la responsabilidad social empresarial. Aunado a ello, la investigación desarrollada por Ghodrati, Yiu y Wilkinson (2018) demuestra que la gestión laboral, la supervisión y el liderazgo y la planificación mejoran el nivel de rendimiento, de seguridad y salud en el trabajo.
A Shift in Aggregation Avoidance Strategy Marks a Long-Term Direction to Protein Evolution
Authors: Foy Scott G , Wilson Benjamin A , Bertram Jason , Cordes Matthew H J , Masel Joanna 
Published: January 2019

AbstractThe current consensus among biologists is that evolution does not have a direction. Here, Foy et al. compare recently-born gene families to genes that are chronologically “more evolved,” finding a striking directionality in the evolution...To detect a direction to evolution, without the pitfalls of reconstructing ancestral states, we need to compare “more evolved” to “less evolved” entities. But because all extant species have the same common ancestor, none are chronologically more evolved than any other. However, different gene families were born at different times, allowing us to compare young protein-coding genes to those that are older and hence have been evolving for longer. To be retained during evolution, a protein must not only have a function, but must also avoid toxic dysfunction such as protein aggregation. There is conflict between the two requirements: hydrophobic amino acids form the cores of protein folds, but also promote aggregation. Young genes avoid strongly hydrophobic amino acids, which is presumably the simplest solution to the aggregation problem. Here we show that young genes’ few hydrophobic residues are clustered near one another along the primary sequence, presumably to assist folding. The higher aggregation risk created by the higher hydrophobicity of older genes is counteracted by more subtle effects in the ordering of the amino acids, including a reduction in the clustering of hydrophobic residues until they eventually become more interspersed than if distributed randomly. This interspersion has previously been reported to be a general property of proteins, but here we find that it is restricted to old genes. Quantitatively, the index of dispersion delineates a gradual trend, i.e., a decrease in the clustering of hydrophobic amino acids over billions of years.
Penguin and Proteus. Imagination as Otherness in me
Authors: Sabolius Kristupas 
Published: January 2019

The question of Otherness is usually taken into account while discussing the Ego’s relation with Others as well as with the World. This article is based on the premises that the function of phantasy melts the subjectivity, revealing the perspective of intersubjectivity within it. On this purpose Sartre’s, Husserl’s and Merleau-Ponty’s researches on the function of imagination, which elucidate the image as the boundary slipping from the centre of Ego, are compared to the story of Hollywood’ movie „Fight Club“. The penguin, which appears in one of the episodes, registers the moment of egological schism, thus becoming the revelation and incarnation of phantasy. While the playful, autonomous and multiform character of imaginary is cleared out, we can ascertain, speaking in Kantian terms, that it has not a complementary or intermediary function, but, in the genesis of transcendental subject, plays the paradoxical role of „allien innerness“ or „inner alienity“. Thought remaining always beside, imagination is a catalyzer which enables crystallization of transcendental forms.
Esoteric Everydayness: the Problem of the Occult, Para-psychological, Esoteric, Magical Discourse in Lithuania
Authors: Pažėraitė Aušra Kristina 
Published: January 2019

In this article, the author examines public discourse in Lithuania (of the beginning of twentyfirst century) concerning esoteric, occult, magic, paranormal, psychic phenomena and practices, in the context of formulation some regulatory legislations on their functioning in media. In this examination several categories of opposing these practices and phenomena attitudes have been identified. And finally, have been provided categorization of this type of movements and phenomena in Lithuania in accordance to definitions of esotericism, occultism, and magic, proposed by contemporary researchers in this field of scientific researches.
On the Possibility of Non-representational Cinema. From André Bazin to Gilles Deleuze
Authors: Brašiškis Lukas 
Published: January 2019

Referring to the ontological arguments shown in the theory of the French film critic and theorist André Bazin and the arguments elaborated by Gilles Deleuze in the fourth chapter of his book Cinema 1: Movement-Image, the possibility of the cinema that does not duplicate the reductive tendencies of the intentional human consciousness is discussed in this article. The classical un-derstanding of the notion of cinematic realism is compared with the idea of non-representational cinema, accentuating the partially technological and partially subjective nature of film, which was described by Bazin, and its way to put the film viewer closer to the perception of the Bergso-nian acentric reality. Instead of giving a clear conclusion, the Bazinian idea of the non-anthropo-centric cinema is actualized in the light of the speculative turn in today’s philosophy.
Dyskusje na temat pomnika Adama Mickiewicza w Wilnie na łamach prasy wileńskiej z lat 1925–1927
Authors: Fedorowicz Irena 
Published: January 2019

Irena FedorovichDiscussions on the Project of A. Mickiewicz’s Monument in Vilna in Press of 1925–1927
The first monument in honour of A. Mickiewicz in Vilna was a bust unveiled in the church of Saint Johns ’ in 1899. However, the Vilnius town-dwellers were willing to erect a monument in a public place. This topic stimulated lots of emotions, especially in the years 1925–1927. Readers of the daily newspapers “Word” (“Słowo”) and “Courier of Vilna” (“Kurier Wileński”) were divided into supporters and opponents of the project of the monument of A. Mickiewicz created by the sculptor S. Szukalski. He was the winner of the competition held in 1926. Under the pressure of public opinion that project was never materialized.Discussion on the monument to A. Mickiewicz in Vilna became a part of a typical Polish cultural discourse in the thirties on the topic of modern art and attitudes of the artists towards the romanticism tradition.
Из истории становления словацкого литературного языка: кодификация А. Бернолака и формирование нормы в текстах бернолаковцев А. Руднаи и Ф. К. Габела
Authors: Лифанов Константин Васильевич Васильевич 
Published: January 2019

Konstantin V. LifanovFrom the History of Formation of the Slovak Literary Language: A. Bernolák’s Codification and Norm Formation in Texts of Bernolák’s Supporters A. Rudnay and Fr.K. Habel
This paper deals with Bernolák’s codification in comparison with the real form of Ber­nolák’s literary language presented in sermons of the Hungarian Cardinal A. Rudnay and translation of the religious treatise from German by Fr. X. Habel. This comparison shows that in real practice Bernolák’s language changed its character, coming nearer to norm of traditional Slovak writing. As a result typical elements, the most widespread in a West Slovak dialect or characterizing peripheral the Záhorie dialect of West Slovakia and the Czech language, forced out the elements concentrated in the Central Slovak dialect. The found out phenomena testifies that the norm essentially different from codification was formed in Bernolák‘s language.
The Progressive Palatalization and the Old Novgorodian Pronoun vъxe
Authors: Галинская Елена Аркадьевна Аркадьевна 
Published: January 2019

The progressive palatalization is one of the most debatable questions of the historical Slavic linguistics. For instance, there is no plausible explanation for the Old Novgorodian pronoun vъxe which does not exhibit the effect of the progressive palatalization. It is attested 23 times in the Novgorodian birch bark letters and in Varlaam’s letter. In 17 cases, there is Ъ in the root, in 5 cases the root has no vowel, and only in one birch bark letter there is Ь in the root. The latter text was written after the fall of yers which makes it possible that Ь marks the assimilative palatalization of [v]. I propose a possible explanations for this situation and argue that Ъ in the root predates the split-off of the Novgorodian dialect from Common Slavic. It is a plausible hypothesis since there are Novgorodian phenomena which came into existence during the Common Slavic period and are unattested in other Slavic dialects. If it is so, there is no need to expect the progressive palatalization in the root vъx- because there were no conditions for that, as there is no front vowel before x.
Новые данные о родстве московской и кирилло-белозерской редакций Стишного пролога (сентябрь–ноябрь)
Authors: Чистякова Марина Владимировна Владимировна 
Published: January 2019

This study of the newly discovered manuscript from the Kirillo-Belozersky redaction of the Verse Prologue (Russian National Library, Kirillo-Belozersky collection 12.1251, XVI–XVII cc.) shows that the composition of the lives of the saints and sermons in the Moscow and Kirillo-Belozersky redactions for September are virtually identical. In comparison with the Moscow redaction, the Kirillo-Belozersky redaction contains several new homilies for October and several new homiletic texts for November, while systematically omitting many of the November sermons of the Moscow redaction. This leads to the conclusion that the idea of producing the Kirillo-Belozersky redaction gradually came into being in the course of copying the manuscript from the Moscow redaction.
Ворожю кусты одного древнерусского поучения, или Семантический вес запятой
Authors: Антропов Николай Павлович Павлович 
Published: January 2019

This paper analyses a fragment of an Old Russian homily from a Corpus of Homilies dating back to 1491. It comprises a word combination “ворожю кусты”, which Alexei Sobolevsky, the first researcher of the text, had separated by a comma, causing a misin terpretation of the fragment. It has been determined that the lexeme кусты found in the Galician-Volhynian Chronicle is unrelated to the one found in the homily. Therefore, this lexeme could be replacing what originally was куксы, appearing as a result of creative copying.
Mежславянские семантические заимствования в русском приказном языке ХVII века
Authors: Гарбуль Людмила Павловна Павловна 
Published: January 2019

The article examines the history of the following words found in the MXVIIth-cen. Muscovite diplomatic correspondence: verne ‘devoted (to), faithfully’, vol(’)no ‘one may, one is allowed’, gruda ‘frozen clod on the road’, dokonati ‘realize, carry out; fulfill, put into practice’, zaživati ‘use, employ’, zamykati ‘complete, conclude (about speech, text)’, zaperetisja ‘deny, refuse to admit; keep one’s mouth shut’. The author shows that these words, in the meanings provided here, are cross-Slavic calques in the Russian written language of the XVIIth.The author argues that these specific meanings of verne, gruda, dokonati, zamykati, and zaperetisja are most likely calques from Polish, and vol(’)no, zaživati in the examined sense are probably semantic calques from the written language of the Grand Duchy of Lithuania.
К истории становления сербского литературного языка: неологизмы в проповедях Гаврилы Стефановича Венцловича
Authors: Гучкова Ирина Вадимовна Вадимовна 
Published: January 2019

The article deals with the neologisms in the sermons of Gavrilo Stefanović Venclović, a Serbian writer of the XVIIIth century, who was among the first to use Serbian vernacular as a standard language for the purpose of writing sermons. After the Vuk type of written language had won, lexical gaps were filled mainly words and expressions already present in the vernacular. This method provided a very limited stylistic and lexical inventory for the writers. Venclović’s stylistic neologisms, possessing such qualities as picturesqueness and semantic transparency, served to draw attention of the audience to the text of the sermon. Rooted in the biblical tradition, they represent a ‘bridge’ between the Old Church Slavonic lexical legacy and the Serbian vernacular, as well as demonstrate the possibility for the creation of a standard language based on vernacular, without divorcement from the tradition of Cyril and Methodius. For a more detailed analysis of the neologisms in the language of Venclović’s sermons the author has chosen the category of verbal nouns with the suffix -lac, which were further categorized into complex and simple nouns, according to the derivation feature.
Словенский язык и словенская национальная, региональная и локальная идентичность
Authors: Кумар Данила Зульян Зульян 
Published: January 2019

Language constitutes an important part of identity; therefore, a definite relationship can be established between the stages of development of the national language and forms of identity. The formation and development of the Slovenian national language, starting in the late seventeenth century, during the period of National Awakening, and of Slovenian national identity can be divided into six stages or periods, all of which saw the social functions of the Slovenian language change. In the 1990’s, emphasis on Slovenian national identity reached its peak, at the same time that the effects of globalization became noticeable in Slovenia, increasing the attention of the Slovenians to their regional and local particularities and the diversity of their local dialects. The article focuses on the different forms of national, local and regional identities that have emerged during this period in Slovenia.
Ekologinės modernizacijos teorija: esminiai bruožai ir kritinės įžvalgos
Authors: Rinkevičius Leonardas 
Published: January 2019

The aim of the article is to discuss the theoretical paradigm of ecological modernization which represents one of the attempts to theorize the issues of enviromental care that only recently became an object of sociological analysis (Catton ir Dunlap, 1979; Buttel, 1987). The article is being developed in a few directions. First, the author develops a comparative analysis of the main sociological perspectives on the environmental care: ecological modernization (Mol, 1995; Weale, 1992; Hajer 1995; Spaargaren, 1997; Rinkevičius, 1998), the theory of risk society and reflexive modernization (Beck, 1992; Beck, Giddens ir Lash 1994), conception of self-purposive capitalistic production (Schnaiberg, 1980) and ecological socialism (Pepper, 1993; Dickens, 1992). Second, in developing such a comparative analysis, the author critically discusses the different theories by concerning both the environmental problems that contemporary societies face and the changes that the societies undergo in the spheres of values and institutions.
Socializacijos modeliai lietuvių biografijose: lyties ir laiko aspektas
Authors: Kraniauskienė Sigita 
Published: January 2019

The article explores models of socialisation and gender identity at different stages of life-course
and in different historical periods. Considerations are based on biographical approach and use data
of the biographical contest “Story of My Life”.
During the process of socialisation gender identity is institutionally transmitted to individuals as a
pattem of social behaviour. Gender identity embodies its own ideology and strategies of interpersonal interactions, where personal biography is a narrative about these interactions shaped by gender. Socialisation evolves as a constant interaction between author and his/her social milieu shaping identity of a person. Each member of society is involved in the process, but their age and in some respect the historical circumstances differently sets their status of a subject or an object of socialisation.
Time (in this case a time period when individual was born and was more intensively engaged in socialisation) is a feature of modern bio graphy (a concept of V. Kavolis) and it allows to identify different worldviews of narrating individuals. Time demarcates traditional and modern worldviews and deterrnines reflexivity of the author. Nevertheless, analysing the collected biographies it is hard to differentiate pure traditional or pure modern ones. To be more precise, the features of modern biographies are usually incorporated into traditional-epic narratives of life stories. On the one hand the relationship of traditional/modem can be understood as a constituent of the narrative, on the other hand it is a representation of the modern worldview in reflexive narration. The traditional framework of narrative contains definite models of gender identities. Traditional duality differentiation of gender roles and structure of patriarchal opposition - is presented as social reality in biographical narratives. The differentiation is imperative and is a warrant of social order and gender identity. But several narratives about the self neglect such manifest differentiation of gender roles. Main distinction of feminine or masculine biographies is based on different perception of self-estimation and social integration.
Moters kelias į akademiją: istorija ir dabartis
Authors: Žvinklienė Rūta 
Published: January 2019

The main idea of the article to show that the practice of
legal “equal rights” even enlarged by concept of “equal opportunities” entails more dissembled and sophisticated forms of women’s discrimination, and therefore gender has remained under the control of public discourse.
In spite of society’s democratisation, the development of gender ideology remained in the frame of Chistian structure: a woman is a servant of a man. Women on the top of social hierarchy, regardless of positive changes towards women’s representation here, were, and are rather an exception than a rule. Sociological analysis of this social phenomenon is based on case study of women in science in Lithuania from a historical-cultural perspective and recent qualitative research data on academic women. Academic women indicate women who are teaching and/or pursuing scientific research in universities and/or scientific research institutions.
Social history may be regarded as a permanent struggle between woman’s exclusion from the so-called public sphere by pushing her towards a private sphere on the one hand, and woman’s strife for inclusion in the public sphere on another hand. The main instrument of this struggle is access to education. Social factors influencing the number of women in science are the public attitudes concerning the standard of sufficient education for a woman, and how science - its branches, its specialization, namely research and/or teaching - is associated with a female carrier.
Despite the trend towards the so-called feminization of definite disciplines, mostly in humanities and social sciences that has a long historical tradition, science is after all a highly masculine activity also, with still visible divisions between masters and servants from a gender perspective. The leadership in academy remains in the frame of the “old boys network”, and the most academic women remain slaves of gender that precludes them from leadership in academy as well. Slaves of gender means that women prefer/are compelled to follow traditional gender patterns that prescribe them main duties in the private sphere.
Solution of socialistic “Women’s question”, that is implementation of the principle of equality between women and men does not achievement of the last generation. The equal rights of individual choice to vote, education, profession, etc. are executed by several generations of Lithuanians, and hence, became an inherent part of the public discourse. That is why the fact of informal women’s discrimination is often perceived as a norm of existing culture or at least non- actual social issues.