bluuebunny/crossref_metadata_2025_split huggingface dataset:
«ВСЕПРАВОСЛАВНЫЙ ЛИДЕР»: ЛОЗАННСКАЯ КОНФЕРЕНЦИЯ ИРОЛЬ КОНСТАНТИНОПОЛЬСКОГО ПАТРИАРХАТАВ ПРАВОСЛАВНОМ МИРЕ
Authors: А.А. Чибисова , П.В. Ермилов 
Published: December 2024

Издревле Константинопольский патриархат имел большое значение для православного мира как один из важнейших церковных центров. Однако к началу 1920-х гг. его существование оказалось под угрозой полного уничтожения из-за потери почти всей своей паствы, покинувшей территорию Турции по итогам греко-турецкой войны. Политические преобразования в Турции поставили под вопрос дальнейшее пребывание патриархата в Стамбуле. Возможным выходом из этой ситуации могло стать доказательство патриархатом своей особой роли в православном мире, которая требовала бы его дальнейшего пребывания в историческом месте. Эта идея удачно совпадала с интересами великих держав, которым не было выгодно удаление патриархата из Константинополя. Заявление Фанаром претензий на всеправославное лидерство стало реакцией на дискуссии о возможности выдворения патриархата с территории Турции, которые велись в рамках Лозаннской мирной конфе-ренции. Именно это обсуждение создало благоприятную почву для развития концепции о Константинопольском патриархате как центре православного мира, которая была использована для давления на турецкое правительство. Немаловажную роль в развитии этой идеи сыграли европейские политики и западная пресса. Данная статья посвящена интерпретации роли Константинопольского патриархата в православном мире странами-участницами Лозаннской конференции в связи с их борьбой за свои политические интересы. Исследование основывается на официальных дипломатических документах и материалах периодической печати.
From ancient times the Patriarchate of Constantinople has played a significant role as one of the most important sees of the Orthodox world. However, by the beginning of the 1920s its existence was under threat of total elimination due to the loss of almost all its flock after the Greco-Turkish war. The ensuing political reforms in Turkey called into question the continued residence of the Patriarchate in Istanbul. A possible way out of this situation for the Patriarchate was to prove its special role in the Orthodox world, a role that demanded its preservation in its historical place. Fortunately, this idea coincided with the interests of the great powers. The Phanar’s claims at Pan-Orthodox leadership came as a reaction to the discussions about the possible expulsion of the Patriarch from Turkey, which were conducted within the framework of the peace conference at Lausanne. It was these discussions that created a favorable background for the conception of the Patriarchate of Constantinople as the center of the Orthodox world. The authors deal in the article with the interpretation of the role of the Patriarch by the participant countries in the Lausanne conference against the background of their struggle for their own political interests. The research is based on official diplomatic documents and periodical press.
ЗАМЫСЕЛ ЕЩЕ НЕ ТОЧКА… СБОРНИК «РУССКАЯ НАУКА» В РЕАЛИЯХ СОЦИАЛЬНОГО ЭКСТРИМА
Authors: В.П. Корзун 
Published: December 2024

Размышление над книгой: Судьба проекта «Русская наука» 1916-1920 (К столетию Комиссии по изданию сборника «Русская наука»): Статьи и документы/ Отв. ред. чл.-корреспондент РАН Ю.М. Батурин; ред.-сост. В.М. Орел, Г.И. Смагина. СПб.; М., 2016. 848 с. Опубликованные статьи и документальные публикации позволяют представить один из первых науковедческих проектов в отечественной науке в контекстах развития мирового науковедения, экстремальных условий Первой мировой войны, революционного и постреволюционного периодов, внутринаучных процессов и практик, индивидуальных стратегий ученых.
Reflection on the book: The fate of the project “Russian Science” 1916-1920 (On the centenary of the Commission for the publication of the collection of “Russian Science”): Articles and documents / Otv.red. Corresponding Member of RAS Yu.M. Baturin; Red.-sost. V.M. Orel, G.I. Smagina. St. Petersburg; M., 2016. 848 p. The published articles and documentary publications make it possible to present one of the first science projects in the Russian science in the context of the development of world science, the extreme conditions of the First World War, the revolutionary and post-revolutionary periods, the intra-scientific processes and practices, and the individual strategies of scientists.
«СУЩЕСТВУЕТ ЛИ СОЦИАЛИСТИЧЕСКАЯ АНТИЧНОСТЬ?»к исследованиям рецепции греко-римской античностив странах Центрально-Восточной Европы
Authors: А.В. Ашаева 
Published: December 2024

В статье рецензируются коллективная монография Classics and Class. Greek and Latin Classics and Communism at School. Warszawa: Wydawnictwo DiG, 2016 («Классики и класс. Греческие и латинские классики и коммунизм в школе»), а также издание A Handbook to Classical Reception in Eastern and Central Europe. Oxford: Wiley-Blackwell Pub., 2017 (Справочник по рецепции античности в Восточной и Центральной Европе), в которых демонстрируется, что проблема рецепции античности становится не только предметом академического интереса, но и актуальной повесткой обсуждения культурной политики, исторической памяти, исторической и культурной идентичности стран Центрально-Восточноевропейского ареала. Этот интерес, в случае с осмыслением античного наследия, оказывается основанным не столько на географических, сколько на социокультурных границах. Под локацию Центрально-Восточноевропейского региона попадают 13 стран (включая помимо Хорватии, Словении, Чехии, Польши, Венгрии, Румынии, Боснии и Герцеговины, Сербии, Черногории, Болгарии, России также Армению и Грузию). Рецензируемые издания, по сути, подводят окончательную черту под вопросом о существовании еще одной самостоятельной традиции обращения к античному прошлому в контексте культурно-исторической специфики региона.
The article reviews the collective monograph «Classics and Class. Greek and Latin Classics and Communism at School. Warszawa: Wydawnictwo DiG, 2016» and «A Handbook to Classical Reception in Eastern and Central Europe. Oxford: Wiley-Blackwell Pub., 2017», which clearly demonstrates that the problem of the reception of Classics is not only a matter of academic interest, but also an urgent agenda for the discussion of cultural policy, historical memory, historical and cultural identity of the countries of the Central-Eastern European area, which, in the case of the comprehension of the ancient heritage, is based not so much on geographical as on sociocultural boundaries. The region of Central and Eastern Europe consist of 13 countries (including in addition to Croatia, Slovenia, Czech Republic, Poland, Hungary, Romania, Bosnia and Herzegovina, Serbia, Montenegro, Bulgaria, Russia, Armenia and Georgia). Peer-reviewed publications, in fact, bring an end to the question of the existence of another independent tradition in connection to the ancient past in the context of the cultural and historical specificity of the region.
Clinical Pharmacology and Side Effects of Venetoclax in Hematologic Malignancies
Authors: Yan Yuting , Guo Yujiao , Wang Ziyi , He Wei , Zhu Yu , Zhao Xiaoli , Sun Luning , Wang Yongqing 
Published: December 2024

:
Venetoclax is a first-in-class B-cell lymphoma/lymphoma-2 (BCL-2) inhibitor that induces apoptosis
in malignant cells through the inhibition of BCL-2. The clinical response to venetoclax exhibits heterogeneity,
and its sensitivity and resistance may be intricately linked to genetic expression. Pharmacokinetic studies
following doses of venetoclax (ranging from 100 to 1200mg) revealed a time to maximum observed plasma
concentration of 5-8 hours, with a maximum blood concentration of 1.58-3.89 μg/mL, and a 24-hour area under
the concentration-time curve of 12.7-62.8 μg·h/mL. Population-based pharmacokinetic investigations highlighted
that factors such as low-fat diet, race, and severe hepatic impairment play pivotal roles in influencing
venetoclax dose selection. Being a substrate for CYP3A4, P-glycoprotein, and breast cancer resistance protein,
venetoclax undergoes primary metabolism and clearance in the liver, displaying low accumulation in the
body.The significance of dose modifications (a 50% decrease with moderate and a 75% reduction with strong
CYP3A inhibitors) and a cautious two-hour interval when co-administered with P-glycoprotein inhibitors are
highlighted by insights from clinical medication interaction studies.

:
Moreover, an exposure-response relationship analysis indicates that venetoclax exposure significantly correlates
not only with overall survival and total response rate but also with the occurrence of ≥ 3-grade neutropenia.
In real-world studies, common or severe side effects of venetoclax include tumor lysis syndrome, myelosuppression,
nausea, diarrhea, constipation, infection, autoimmune hemolytic anemia, and cardiac toxicity,
among others. In this review, we summarize the current clinical pharmacology studies and side effects of venetoclax,
which showed that the approved dosage of venetoclax is relatively wide, and the dosage for different
hematologic populations can be streamlined in the future.
A Mechanism-based Perspective on the Use of Flavonoids in the Treatment of Diabetes and its Complications
Authors: Pattanaik Sandesh Kumar , Anil Manisha Prajapati , Jena Sudipta , Rath Diptirani 
Published: December 2024

Abstract:
Diabetes is a chronic, irreversible, non-infectious metabolic syndrome associated with
low insulin production by the pancreas or due to insulin resistance. The management landscape
for diabetes is swiftly evolving due to ongoing advancements. Conventional treatment approaches
have struggled to fully address the root causes of the disease while also carrying significant risks
of adverse effects. Flavonoids are an extensive class of phytonutrients present in grains, vegetables,
fruits, cocoa, tea, wine, and nuts. Many studies have reported that flavonoids have shown diversified
pharmacological activity in recent years. Thus, this review will give you an overview of
the significant anti-diabetic potential of promising flavonoids. Various search engines such as
PubMed, Scopus, Google Scholar, and WoS have been explored by using the keywords “apigenin,”
“luteolin,” “naringenin,” “hesperidin,” “kaempferol,” “quercetin,” “myricetin” and “taxifolin”
with “anti-diabetic.” The anti-diabetic activity of flavonoids is attributed to various mechanisms,
including α glucosidase, α-amylase inhibitory effects, GLUT4 expression, antioxidant, and apoptosis.
However, their inadequate biopharmaceutical qualities make their effectiveness in clinical
translation constrained. This review aims to highlight plant-derived flavonoids through in-vitro, in-
-vivo, and clinical insights. Additionally, the review highlights the recent advancement in the drug
delivery system in diabetes to overcome the limitation of flavonoids.
Effect of hydrostatic thrust bearing oil pad structure on performance
Authors: Yang Xiaodong , liu shouguo , Wang Lutong , Liu Hongbo , Peng Jiakuan 
Published: December 2024

Background:
The hydrostatic thrust bearing is a liquid lubrication technology based on
the principle of hydrostatic pressure, characterized by high load-carrying capacity, low friction, and
long lifespan. It has been widely applied in precision machinery and the spindles of high-speed,
high-precision equipment. The oil pad of the hydrostatic thrust bearing is a crucial component, and
its geometric structure significantly influences the bearing performance. During operation, the oil
film of the hydrostatic thrust bearing is subjected to high loads and temperatures. If the oil film does
not have sufficient strength, it can affect the normal operation of the bearing, leading to accidents.
The oil pad structure is a key factor affecting the strength of the oil film. Therefore, the rational design
of the oil pad structure is essential to ensure the performance of the hydrostatic bearing and
prolong its service life.

Objective:
This study aimed to summarize the impact of different oil pad structures on the performance
of hydrostatic thrust bearings, providing a basis for the future development of hydrostatic
thrust bearings.

Method:
A search for journals, patents, conferences, and papers related to hydrostatic thrust bearings
was conducted, and the impact of oil pad structures on hydrostatic thrust bearings was summarized
and analyzed.

Results:
Based on the research findings of numerous scholars, this study summarizes the impact of
oil pad structures on the performance of hydrostatic thrust bearings. It describes how the oil pad
shape, oil pocket shape, oil pocket depth, and microtextures affect the overall performance of thrust
bearings. The research methods employed are analyzed, and a concluding summary is provided regarding
the influence of bearing oil pad geometric structures on bearing performance.

Conclusion:
This paper provides guidance for the design and optimization of the oil pad in hydrostatic
thrust bearings. Finally, it outlines the future development trends of the oil pad in hydrostatic
thrust bearings and provides prospects for future development trends and key areas of focus for hydrostatic
thrust bearings.
Multi-Objective Optimization of MEMS-based Box Pattern Microheaters Using Response Surface Method
Authors: Setyawati Onny , Choiron Moch. Agus , Bangert Axel , Sandhagen Carl 
Published: December 2024

We present a response surface method to evaluate multi-objective optimization for MEMS-based microheater design. Box pattern, the standard microheater shape, was selected in this study since it has a uniform temperature distribution compared to other patterns. The optimum parameters are used to obtain the maximum total current density and Joule heat. Based on a hybrid of the Response Surface Method and Central Composited Design, the model simulation emerged with 25 sets of Design Experiments. As expected, the voltage is proportional to the increased output temperature and Joule heat of the microheater. Material thermal conductivity, anchor length and thickness of the heating element are included as design variables for the optimization. The microheater thicknesses of 4.23 - 4.55 µm, length of 40 µm and thermal conductivity of materials of approximately between 52 to 66 Wm-1K-1 became the optimized results at 1 V input voltage to obtain a maximum Joule heat of 4.9x105 W/mm3 and total current density of 5.6x107 mA/mm2.
Aspek Pedagogik dan Konteks Materi Kimia dalam Pendidikan Kejuruan dan Teknik: Systematic Literature Review
Authors: Irawan Nisrina Zahira Putri , Anwar Sjaeful , Munawaroh Heli Siti Halimatul 
Published: December 2024

Tujuan penelitian ini adalah untuk: 1) Mengidentifikasi konteks materi kimia di pendidikan teknik dan kejuruan; 2) Menginvestigasi aspek pedagogik yang telah diterapkan pada pembelajaran kimia dalam pendidikan teknik dan kejuruan serta dampaknya terhadap kompetensi siswa/mahasiswa. Penelitian ini meninjau 33 artikel pada tahun 2020-2024 dari database Scopus dan Semantic Scholar. Temuan studi ini yaitu pendidikan teknik dan kejuruan paling banyak mengembangkan materi kimia yang berhubungan dengan konteks bahan bakar kendaraan bermotor, minyak bumi, dan pemanfaatan sel elektrokimia sebagai energi terbarukan. Pembelajaran berbasis TIK, STEM, dan pengembangan modul terbukti dapat meningkatkan penguasaan konsep kimia di pendidikan teknik dan kejuruan. Rekomendasi penelitian berikutnya adalah pengembangan konteks materi kimia yang dapat berdampkak terhadap keterampilan abad 21 seperti kreativitas, berpikir kritis, kolaborasi, pemecahan masalah, entrepreneurship, dan metakognitif. Pengembangan tersebut dapat didukung dengan pendekatan STEM, Project-based Learning, Problem-based Learning, chemoentrepreneurship, etnokimia, serta media pembelajaran berbasis Artificial Intelligence atau Virtual Reality pada pembelajaran kimia di pendidikan kejuruan.
Testicular inguinal ectopia following hernia repair in children
Authors: Zolotukhin D. S. , Pavlova O. S. , Filatov I. A. 
Published: December 2024

Introduction. Inguinal ectopic testis is a rare complication after inguinal hernia repair. In modern literature, there are few articles devoted to this problem.Objective. To study the testicular elevation mechanisms after inguinal hernia surgery in children and methods to treat this complication.Materials & methods. A cross-sectional retrospective analysis of medical records of male children who underwent inguinal plasty between January 2018 and December 2023 was performed at the Chelyabinsk Regional Children's Clinical Hospital. Those who underwent subsequent orchopexy for ipsilateral cryptorchidism were identified. Cryptorchidisms that were misdiagnosed were excluded.Results. A total of 1140 boys with inguinal hernias were treated, of which 978 (86%) were operated on laparoscopically using the PIRS technique, and 162 (14%) underwent open hernia repair. In nine (0.7%) children, an ectopic testicle in the groin was detected after surgery. During orchiopexy, extensive adhesions and scars in the inguinal canal were found only in two cases after open plastic surgery. The processus vaginalis remained intact after laparoscopic repair and partially after open hernia repair.Conclusion. Ectopic testicles in patients undergoing inguinal hernia repair can be successfully treated with orchiopexy performed through the inguinal approach.
Eliciting Preferences for the Uptake of Smoking Cessation Apps: Discrete Choice Experiment
Authors: Szinay Dorothy , Cameron Rory A , Jones Andy , Whitty Jennifer A , Chadborn Tim , Brown Jamie , Naughton Felix 
Published: December 2024

Background
If the most evidence-based and effective smoking cessation apps are not selected by smokers wanting to quit, their potential to support cessation is limited.

Objective
This study sought to determine the attributes that influence smoking cessation app uptake and understand their relative importance to support future efforts to present evidence-based apps more effectively to maximize uptake.

Methods
Adult smokers from the United Kingdom were invited to participate in a discrete choice experiment. Participants made 12 choices between two hypothetical smoking cessation app alternatives, with five predefined attributes reflecting domains from the theoretical domains framework: (1) monthly price of the app (environmental resources), (2) credible source as app developer (social influence), (3) social proof as star rating (social influence), (4) app description type (beliefs about consequences), and (5) images shown (beliefs about consequences); or opting out (choosing neither app). Preferences and the relative importance of attributes were estimated using mixed logit modeling. Willingness to pay and predicted uptake of the most and least preferred app were also calculated.

Results
A total of 337 adult smokers completed the survey (n=168, 49.8% female; mean age 35, SD 11 years). Participants selected a smoking cessation app rather than opting out for 90% of the choices. Relative to other attributes, a 4.8-star user rating, representing social proof, was the strongest driver of app selection (mean preference parameter 2.27, SD 1.55; 95% CI 1.95-2.59). Participants preferred an app developed by health care–orientated trusted organization (credible source) over a hypothetical company (mean preference parameter 0.93, SD 1.23; 95% CI 0.72-1.15), with a logo and screenshots over logo only (mean preference parameter 0.39, SD 0.96; 95% CI 0.19-0.59), and with a lower monthly cost (mean preference parameter –0.38, SD 0.33; 95% CI –0.44 to –0.32). App description did not influence preferences. The uptake estimate for the best hypothetical app was 93% and for the worst, 3%. Participants were willing to pay a single payment of up to an additional US $6.96 (UK £5.49) for 4.8-star ratings, US $3.58 (UK £2.82) for 4-star ratings, and US $2.61(UK £2.06) for an app developed by a trusted organization.

Conclusions
On average, social proof appeared to be the most influential factor in app uptake, followed by credible source, one perceived as most likely to provide evidence-based apps. These attributes may support the selection of evidence-based apps.
Decomposition of Heart Failure Prevalence and Mortality Among Older Adults in the United States: Medicare-Based Partitioning Analysis
Authors: Yu Bin , Kravchenko Julia , Yashkin Arseniy , Akushevich Igor 
Published: December 2024

Abstract

Background
Heart failure (HF) is a challenging clinical and public health problem characterized by high prevalence and mortality among US older adults, along with a recent decline in HF prevalence and increase in mortality. The changes of prevalence can be decomposed into pre-existing disease prevalence, disease incidence, and respective survival, while the changes of mortality can be decomposed into mortality in the general population independent from HF, pre-existing HF prevalence, incidence, and respective survival. These epidemiological components may contribute differently to the changes in prevalence and mortality.

Objective
We aimed to investigate and compare the relative contributions of epidemiologic determinants in HF prevalence and mortality trends.

Methods
This study was a secondary data analysis of 5% of Medicare claims data for 1992‐2017 in the United States. Medicare is a federal health insurance program for older adults aged 65+ years as well as people with specific disabilities and end-stage renal disease. Age-adjusted prevalence and incidence-based mortality (IBM; all-cause mortality that occurred in patients with HF) were partitioned into their respective epidemiologic determinants using the partitioning analysis approach.

Results
The age-adjusted HF prevalence (1/100 person-years) increased from 11 in 1994 to 14.6 in 2005, followed by a decline to 12.6 in 2017, and the age-adjusted HF IBM (1/100,000) increased from 2220.8 in 1994 to 2563.7 in 2000, then declined to 2075.9 in 2016, followed by an increase to 2094.7 in 2017. The HF incidence (1/1000 person-years) declined from 29.4 in 1992 to 19.9 in 2017. The 1-, 3-, and 5-year survival trend showed declines in recent years. Partitioning of HF prevalence showed three phases: (1) decelerated increasing prevalence (1994‐2006), (2) accelerated declining prevalence (2007‐2014), and (3) decelerated declining prevalence (2015‐2017). During the whole period, the decreasing HF incidence contributed to the declines in prevalence, overpowering prevalence increases contributed from survival. Likewise, partitioning of HF IBM showed three phases: (1) decelerated increasing mortality (1994‐2001), (2) accelerated declining mortality (2002‐2012), and (3) decelerated declining mortality (2013‐2017). The decreasing HF incidence in 1994‐2017 and increasing survival in 2002‐2006 contributed to the declines in mortality, while the decreasing survival in 2007‐2017 contributed to the mortality increase.

Conclusions
Decade-long declines in HF prevalence and mortality mainly reflected decreasing incidence, while the most recent increase of mortality was predominantly due to the declining survival. If current trends persist, HF prevalence and mortality are forecasted to grow substantially in the next decade. Prevention strategies should continue the prevention of HF risk factors as well as improvement of treatment and management of HF after diagnosis.