bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Molecular Imaging through a Versatile Peptide Nanofiber for Self‐Assembly and Precise Recognition
Authors: Zhang Limin , Zhao Jinge , Ma Bokai , Wang Xin , Zhang Jian , Wang Weizhi 
Published: November 2024

AbstractDesigning molecules for multivalent targeting of specific disease markers can enhance binding stability which is critical in molecular imaging and targeted therapy. Through rational molecular design, the nanostructures formed by self‐assembly of targeting peptides are expected to achieve multivalent targeting by increasing the density of recognition ligands. However, the balance between targeting peptide self‐assembly and molecular recognition remains elusive. In this study, we designed a targeting‐peptide‐based imaging probe system TAP which consist of the signal unit, the recognition motif, the assembly motif and a Pro‐leverage. It is verified that TAP could specifically binds to PD‐L1‐positive tumor cells in a multivalent manner to produce biological effects, and could also be combined with imaging probes through unique self‐assembly strategies. By the balance between the peptide self‐assembly and targeting recognition, the specificity and stability can be improved while the accumulation capacity of the probes at the tumor site can be greatly enhanced compared with the conventional strategy, thus reducing side effects, providing an effective tool for diagnostic and therapeutic integration of tumors.
Coexisting nutcracker phenomenon and refractory hypertension in a patient with IgA nephropathy: A case report and literature review
Authors: Wang Fengmei , Li Xinru , Liu Ran , Wang Yao , Liu Lili , Zhang Xiaoliang , Liu Bicheng 
Published: November 2024

Key Clinical MessageThe entrapment of the left renal vein (LRV) may contribute to changes in hemodynamics within kidney and could also be associated with IgA nephropathy (IgAN). Although the relationship between the nutcracker phenomenon and IgAN has not yet been elucidated, it is speculated that this patient's refractory hypertension is a combined effect of nutcracker syndrome (NCS) and IgAN.
How Ir–Rh Alloys Improve Electrochemical Ammonia Oxidation Activity Studied by Density Functional Theory
Authors: Laframboise Brendan J. R. , Johnston Shayne J. , Chen Leanne D. 
Published: November 2024

AbstractThe electrochemical ammonia oxidation reaction (AOR) has applications in hydrogen storage and ammonia waste remediation. Using density functional theory, we investigate the mechanism of AOR on Ir, Rh, and their alloys at varied atomic ratios (, , and ) toward (g), (aq), and (aq) formation. This work introduces a method for computational alloy design by considering both electronic energy and configurational entropy. The structures considered are selective to (g) formation and all favored *N–N coupling. An alloy was found to reduce the theoretical onset potential for (g) formation relative to pure Ir while not exhibiting a downhill coupling step corresponding to catalyst poisoning by *N as shown for pure Rh, consistent with previous experimental work. The formation of (aq) and (aq) demand significantly higher potentials, typically limited by the final hydroxylation step before desorption.
CuO/CeO2 Nanocomposites With p–n Heterojunction for Photocatalytic CO2 Reduction to CH4
Authors: Ce Mengmeng , Xue Qingxiao , Wang Yixuan , Yi Kunhe , Liu Xuan‐He , Wu Congyi 
Published: November 2024

AbstractCH4 is a significant fuel with considerable industrial value. Photocatalytic CO2 reduction presents an effective strategy for producing CH4, offering a green, environmentally friendly, and sustainable solution. However, challenges such as inefficient light absorption and inadequate separation and transport of photogenerated electron‐hole pairs are crucial barriers to its progress. Herein, an efficient CuO/CeO2 photocatalyst with p‐n heterojunction was prepared for the photocatalytic reduction of CO2 to CH4. CuO/CeO2 exhibited improved light absorption efficiency, along with enhanced separation and transport of photogenerated charges, leading to superior photocatalytic performance compared with individual CuO and CeO2. Only CO was detected on CuO or CeO2. In contrast, CuO/CeO2 produced CH4 and C2H4 at yields of 80.2 µmol·g−1 and 2.1 µmol·g−1 within 4 h, respectively. And the selectivity for CH4 reached up to 97.4%.
Production of Tagatose from Galactose with CaO at Room Temperature
Authors: Zhao Jikai , Cruz Ethan , Shi Xiaolei , Rankin Scott A. , Huber George W. 
Published: November 2024

AbstractThis study investigates the efficacy of Sn‐β zeolite, triethylamine, and CaO in the isomerization of galactose to tagatose. At temperatures over 80 °C, all three reagents exhibited low tagatose yield (< 20%). Notably, at 100 °C and a CaO/galactose molar ratio of 1/5, a galactose conversion of 64% was achieved with a tagatose selectivity of 17%. The tagatose selectivity decreased over time at this temperature. However, at room temperature, a tagatose selectivity of 56% and 73% with a CaO to galactose molar ratio of 1/1 and 2/1, respectively, was obtained with a 100% galactose conversion after 40 min of reaction. The galactose conversion had a linear relationship with the molar ratio of CaO/galactose at room temperature. This indicates that CaO functions as a stoichiometric reagent rather than a catalyst. A yellowish gel‐like complex formed when the CaO/galactose molar ratios exceeded 1/2. It is noteworthy that these phenomena were not observed with MgO. In addition, low isomerization conversion from glucose to fructose was observed with CaO.
Advances in Tandem Strategies for CO2 Electroreduction: From Electrocatalysts to Reaction System Design
Authors: Sui Peng‐Fei , Wang Yi‐Cheng , Wang Xiaolei , Liu Subiao , Luo Jing‐Li 
Published: November 2024

AbstractThe electrochemical reduction of CO2 (CO2RR) offers the opportunity to store renewable energy in the form of chemicals and fuels while simultaneously reducing CO2 emissions. Compared to low carbon products such as carbon monoxide and formic acid, multicarbon products have demonstrated greater value in terms of economic feasibility. To date, various strategies have been developed to enhance electrocatalytic performance, with tandem strategies emerging as a promising approach, particularly for the formation of multicarbon products. In this review, current tandem strategies regarding CO2RR are thoroughly discussed, covering electrocatalyst designs from atomic‐scale tandem electrocatalysts to macroscale electrode configurations as well as reaction system designs. Additionally, the internal reaction processes involving reduction product upgrades, the application of multi‐physical tandem fields, and the tandem reaction systems are further summarized. This review aims to provide more fundamental insights into tandem strategies for CO2RR applications and inspire more creative ideas in the research community of CO2RR in light of this promising approach with its wide versatility, diversity, and flexibility.
Chalcogen‐Bonding Catalyzed In Situ Trityl Cation Activation for C—C Bond Forming Reactions
Authors: Lohmann Niklas , Fengler Kevin , Keuper Alica C. , García Mancheño Olga 
Published: November 2024

AbstractIn this work, the use of chalcogen bonding for the catalytic activation of trityl cation by chloride abstraction from bench stable trityl chloride and further application in C—C bond forming reactions is reported. In particular, telluronium salts bearing noncoordinative counter anions such as BArF24 proved highly efficient. Thus, low catalyst loading of 1 mol% allows for the trapping of the in situ generated trityl cation in a Friedel–Crafts reaction, as well as its use as catalyst in the carbonyl‐ene cyclization of citronellal or as hydride‐type oxidant in diastereoselective C—H functionalization/cyclization of tetrahydroisoquinoline derivatives. A new family of chiral chalcogen–triazolium salts presenting the chirality in the central backbone was also designed and employed in the C—H functionalization reaction, slightly outperforming hydrogen and halogen bonding activation. Although no appreciable chirality transfer has been achieved so far, those simple and modular structures might open new possibilities toward enantioselective chalcogen catalysis.
Perceptions or behavior? An evaluation of CFPB's financial well‐being scale using household financial ratios
Authors: Khashadourian Edmund , Harrison Adele L. 
Published: November 2024

AbstractThis article creates a typology to assess four categories of financial well‐being based on a combination of household financial ratios. Most financial well‐being scales are based on subjective measures (i.e., perceptions), as objective markers have not reliably encapsulated financial well‐being. We define a conceptual model, the equilibrium model of the household (EMH), and use discriminant analysis to extract categories of financial well‐being. The continuum of these categories is financially distressed (lowest), financially fragile, financially stable, and financially flourishing (highest). Our results demonstrate these categories are consistent with the Consumer Financial Protection Bureau's (CFPB) Financial Well‐Being Scale, a subjective scale. Higher CFPB scores were associated with higher category ranks. Our results provide additional evidence to support construct validity of the CFPB scale and may offer more actionability to the CFPB scores because specific financial outcomes/behaviors associated with our categories of financial well‐being correspond to ranges of the CFPB scale. However, we argue that the claim whereby the CFPB scale measures a concept beyond traditional financial measures is imprecise and may even reflect the existence of noise in the CFPB's data, raising questions about its reliability.
Synthesis, Structures and Air‐stable N‐type Organic Field‐effect Transistor (OFET) Properties of Functionalized‐phenanthrene Conjugated Asymmetric N‐heteroacenes
Authors: Liu Zepeng , Hua Yu , Xu Jiqiang , Zhao Wenkai , Long Guankui , Yang Jiaxiang , Zhang Qichun , Zhang Guobing , Wang Chengyuan 
Published: November 2024

AbstractThe development of stable high‐performance n‐type organic semiconductors for applications in organic field‐effect transistors (OFETs) under ambient conditions is desirable but challenging. To address this issue, we here synthesized a series of functionalized‐phenanthrene conjugated asymmetric N‐heteroacenes, where the phenanthrene moiety was modified by N substitution or Br functionalization at different positions to induce various degrees of asymmetry in their structures. The photophysical and electrochemical properties of these molecules were studied, and their packing patterns were analysed. The OFETs based on these materials were fabricated through simple spin‐coating method, and the as‐resulted thin films were treated with different conditions. The devices exhibit typical n‐type performances under ambient conditions with charge carrier mobilities up to 4.27×10−3 cm2 V−1 s−1. The crystallinities and morphologies of these thin films were studied to investigate the correlations between the device performances and thin‐film characteristics. Our study suggests that phenanthrene conjugated N‐heteroacenes can be developed as promising air‐stable solution‐processable n‐type semiconducting materials, and Br modification at certain positions of phenanthrene is beneficial in adjusting the thin‐film properties for the improvement of OFET performances.
Isoreticular Contraction in Dicopper Paddle‐Wheel‐Based Metal‐Organic Frameworks to Enhance C2H2/CO2 Separation
Authors: Du Guo‐Tong , Wang Yi , Liu Teng‐Long , Yue Zheng‐Qi , Ma Ya‐Nan , Xue Dong‐Xu 
Published: November 2024

AbstractAchieving a balance between high selectivity and uptake is a formidable challenge for the purification of acetylene from mixtures with carbon dioxide, particularly when seeking to maximize both C2H2 adsorption capacity and C2H2/CO2 separation selectivity in crystalline porous materials. In this study, leveraging the principles of reticular chemistry, we selected two tetracarboxylate‐based linkers and combined them with Cu2+ ions to synthesize two isoreticular dicopper paddle‐wheel‐based metal‐organic frameworks (MOFs): Cu‐TPTC (terphenyl‐3,3’,5,5’‐tetracarboxylic acid, H4TPTC) and Cu‐ABTC (3,3,5,5‐azobenzenetetracarboxylic acid, H4ABTC). The structural and sorption analyses revealed that Cu‐ABTC, despite having slightly smaller pores due to the strategic replacement of a phenyl ring with an azo group between two tetratopic ligands, maintains high porosity compared to Cu‐TPTC. Furthermore, Cu‐ABTC outperforms Cu‐TPTC in terms of C2H2 adsorption capacity (196 cm3 g−1 at 298 K and 1 bar) and C2H2/CO2 separation selectivity (16.5~5.6). These findings were corroborated by dynamic breakthrough experiments and computational modeling. This research highlights the potential of the isoreticular contraction strategy in enhancing MOFs for sophisticated gas adsorption and separation processes.
Design and Evaluation of Azaspirocycles as RNA binders
Authors: Fleurisson Claire , Graidia Nessrine , Azzouz Jihed , Di Giorgio Audrey , Gaysinski Marc , Foricher Yann , Duca Maria , Benedetti Erica , Micouin Laurent 
Published: November 2024

AbstractThis study presents efficient synthetic pathways for preparing novel azaspirocycles. These methodologies involve functionalizing key bicyclic hydrazines with a substituent on one of their bridgehead carbon atoms. The desired spirocyclic cores were successfully obtained through double reductive amination reactions, intramolecular cyclizations, and cleavages of the N−N bond. The isolated molecules possess unique three‐dimensional structures, suggesting potential applications in medicinal chemistry and drug discovery. With the growing interest in targeting nucleic acids as a complementary approach to protein‐targeting strategies for developing novel active compounds, we investigated the potential of the synthesized azaspirocycles as RNA binders. As a proof of concept, we highlight the promising activity of some compounds as strong binders of HIV‐1 TAR RNA and inhibitors of Tat/TAR interactions.
Quenching Rate Constants of Lewis Base‐Boryl Radical by Substrates: a Laser Flash Photolysis Study
Authors: Zhang Fan , Li Yuanming , Zhou Xi , Zhao Qiang , Li Xuelian , Zhang Feng‐Lian , Wang Yi‐Feng , Zhou Xiaoguo 
Published: November 2024

AbstractThe advanced strategy using Lewis base‐boryl radicals (LBRs) has recently been proposed for the addition of alkyl substituents to the full‐carbon quaternary center of an organic molecule. However, as the rate‐determining step in the whole route, reaction rate constants of LBRs with substrates are extremely lacking. In this paper, 4‐dimethylaminopyridine (DMAP)‐BH2⋅ was selected as a representative of LBRs, and its reactions with six monochloro‐substituted substrates, including three methyl chlorobenzoates and three chlorinated acetanilides were studied in experiments and theoretical calculations. The bimolecular reaction rate constants, kq, were determined using laser flash photolysis approach. By comparing activation energies along the two addition pathways, we have clarified the rate‐determining step as the attacking to carbonyl oxygen instead of chlorine atom. Furthermore, noncovalent interaction (NCI) analyses on these substrates indicate that weak interactions, such as hydrogen‐bonding and van der Waals interactions, have significant influence on the reactivity of these substrates. Our study provides concrete clues to extend this synthetic strategy.
Resilience and Religious Coping in Libyan Survivors of Hurricane Daniele
Authors: Ali Mohamed , Altaeb Hawwa , Abdelrahman Rasha Mohamed 
Published: November 2024

ABSTRACTThe aim of the study was to investigate the mediating roles of resilience, posttraumatic growth (PTG) and religiosity between the impact of hurricane trauma and psychological distress. Using a cross‐sectional design, the study involved 101 Libyan participants with an average age of 30.43 years (SD = 9.59), of whom 72% were women. Participants completed validated tests, including the Impact of Event Scale (IES), Brief Resilience Scale, Muslim Religiosity Scale and Patient Health Questionnaire (PHQ). The results indicated that posttraumatic stress symptoms (PTSS) were not associated with PTG (r = 0.04, p > 0.05) or religiosity (r = 0.02, p > 0.05) but were negatively associated with resilience (r = −0.39, p < 0.001) and positively associated with psychological distress including anxiety (r = 0.72, p < 0.001) and depression (r = 0.69, p < 0.001). Structural equation modelling (SEM) revealed that only resilience positively mediated the association between PTSS and anxiety (indirect effect = 0.04, p = 0.031), while PTSS positively predicted psychological distress (β = 0.037, p < 0.001). Network analysis identified parent loss is strongly connected with intrusion (r = 0.121), as most central node, while partner loss was associated with hyperarousal (r = 0.063), irritability (r = 0.036) and both share the same connection with numbing, while interestingly partner and friends loss share connection with resilience (r = 0.177). The study concludes that urgent clinical interventions, such as trauma‐focused cognitive behavioural therapy, are required for the affected individuals, with a focus on enhancing resilience as a protective factor against PTSS.
Evaluation of Alveolar Bone Destruction Patterns in the Posterior Region of the Maxilla Through Cone Beam Computer Tomography on 361 Consecutive Patients: Effect of Age and Gender
Authors: Pekiner Filiz Namdar , Yılmaz Gözde , Keser Gaye , Eyüboğlu Tan Fırat , Özcan Mutlu 
Published: November 2024

ABSTRACTObjectivesThe aim of this retrospective study is to evaluate the effect of age and gender on the alveolar bone destruction pattern with cone beam computed tomography (CBCT) in the posterior region of the maxilla.Materials and MethodsThe study group included CBCT image records of 361 consecutive patients (180 males and 181 females) aged 20 years and older. Alveolar crest morphology in the maxillary right and left first and second molar teeth on retrospective images was classified as a horizontal or vertical defect (one‐walled, two‐walled, three‐walled, and combined bone defect) on four surfaces (mesial, distal, buccal, and palatinal). Bone crater defects were defined, and furcation involvements and combined periodontal–endodontic lesions (CPELs) were placed in another category.ResultsIn 361 patients, 1444 teeth were evaluated from adults between 20 and 63 years of age; 49.9% of the patients were male and 50.1% were female. Female patients had a considerably greater rate of one‐walled horizontal damage in the right molar teeth than male patients (p = 0.002; p < 0.05). Patients with combined horizontal destruction in the right and left molar teeth, horizontal destruction in the palatinal, and horizontal three‐walled destruction had a significantly higher mean age than patients without these periodontal destructions (p = 0.000; p < 0.05). Males were shown to have statistically higher frequencies of horizontal defects when defects were combined or distally and palatally located.ConclusionsAge and gender affect the alveolar bone loss pattern. Except for single‐walled destructions, it has been found that the frequency of horizontal destruction increases with age. Horizontal destruction in the palatinal along with horizontal three‐walled destruction increased with age.
Exploring the Variations in the Use of Modified Dental Anxiety Scale (MDAS) in Literature: A Survey of Studies Published from 2014 to 2023
Authors: Yeung Andy Wai Kan 
Published: November 2024

ABSTRACTObjectivesModified Dental Anxiety Scale (MDAS) is a frequently used psychometric tool to evaluate the dental anxiety level of dental patients or the general population. However, it was largely unclear if MDAS was consistently administered in the original format in the academic literature. This work aimed to survey the literature published in the last 10 years to reveal the current usage of MDAS.MethodsWeb of Science and Scopus were queried to identify papers that mentioned the use of MDAS.ResultsAmong a total of 260 analyzed papers, 101 papers included comprehensive information regarding both the questions posed and the response format employed. Two papers only used an explicitly renamed MDAS with modified contents. Among the 258 papers that used MDAS that were supposed to be standardized, many discrepancies from the original version were discovered. There were only 39 papers that strictly followed the recommended scoring scheme: if a participant had a score of ≥ 19, he or she might be highly dentally anxious. Notable modifications included the use of a cut‐off score different from the original recommendation, the use of multiple cut‐off scores, modifications of the response format or descriptors, and modifications to the question items especially adding extra questions.ConclusionsThese modifications would create confusion when researchers and clinicians tried to compare data across studies. Researchers are recommended to administer MDAS in its original format.
Anti‐Porphyromonas gingivalis Antibody Levels in Patients With Stroke and Atrial Fibrillation: A Systematic Review and Meta‐Analysis
Authors: Cannavo Alessandro , Babajani Nastaran , Saeedian Behrad , Ghondaghsaz Elina , Rengo Sandro , Khalaji Amirmohammad , Behnoush Amir Hossein 
Published: November 2024

ABSTRACTObjectivesAtrial fibrillation (AF) and stroke are two highly related conditions, with periodontitis and periodontal pathogens, such as Porphyromonas gingivalis (Pg), appearing to be the most prominent common risk factors. In this study, we evaluated studies assessing Pg infection via serum/plasma anti‐Pg antibodies in patients with AF and/or stroke.Material and MethodsOnline databases (PubMed, Scopus, Embase, and the Web of Science) were screened for studies showing the association between anti‐Pg antibodies with stroke and/or AF. Relevant data were extracted, and a subsequent random‐effects meta‐analysis was performed to calculate the pooled odds ratio (OR) or standardized mean difference (SMD) and 95% confidence intervals (CIs) for Pg seropositivity or anti‐Pg antibody levels in stroke patients compared to controls.ResultsSixteen studies were included in the systematic review. Based on the meta‐analysis performed, there was no significant difference in Pg IgA and IgG levels between patients with stroke and controls (IgA: SMD 0.11, 95% CI −0.02 to 0.25, p = 0.1; IgG: SMD −0.12, 95% CI −1.24 to 0.99, p = 0.83). Similarly, no difference was observed between these groups in terms of Pg IgA and IgG seropositivity (IgA: OR 1.63, 95% CI 1.06–2.50, p = 0.026; IgG: OR 2.30, 95% CI 1.39–3.78, p < 0.001). Subsequently, we reviewed the results of six articles investigating serum or plasma IgG antibodies against Pg in patients with AF. Our results revealed a strict association between Pg infection and AF, with AF patients exhibiting either higher anti‐Pg antibody levels or a higher prevalence of positive serum Pg antibodies.ConclusionsOur study supports the clinical utility of Pg infection assessment in patients with periodontitis and those with AF and solicits more focused studies to corroborate its use in clinical settings to enhance overall outcomes, reduce the risk of complications like stroke, and help fine‐tune personalized therapies.