bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiencia Cooperativa de Mondragón: la educación cooperativa como un proceso de transformación social
Authors: Alcântara Liliane Cristine Schlemer , Sampaio Carlos Alberto Cioce , Zabala Leire Uriarte 
Published: September 2018

Este artículo pretende mostrar una propuesta de educación cooperativa potenciadora de la articulación entre prácticas productivas y prácticas educativas, o sea, entre reflexión y acción, como factor potenciador del proceso de enseñanza-aprendizaje para el desarrollo individual y social. La propuesta parte de una investigación cualitativa – estudio de caso y observación participante – del Modelo de Educación Cooperativa del movimiento cooperativo de Mondragon. La interpretación de los datos se ha llevado a cabo siguiendo la metodología del Discurso del Sujeto Colectivo (DSC) con ayuda del software QualiQuantiSoft®. En esta propuesta se vislumbra la educación cooperativa como factor de expresión y realización de los principios de la solidaridad y transformación social para avanzar en los procesos de desarrollo territorial sostenible.
¿Economía alternativa o tecnopolítica? Activismo desde el consumo cooperativo de productos agroecológicos
Authors: Espelt Rodrigo Ricard , Peña-López Ismael , Rodríguez Enrique 
Published: September 2018

El cooperativismo agroecológico se configura a través del encuentro de dos corrientes que, a veces, han tenido trayectorias paralelas: el cooperativismo y la agroecología. En cualquier caso, ambos movimientos tienen como elemento común su dimensión política. En el contexto de la era de la Sociedad Red y de la expansión de las Tecnologías de la Información y la Comunicación (TIC), este artículo estudia el vínculo entre los grupos de consumo agroecológico, como instrumento de promoción de una economía alternativa, y los movimientos sociales, como espacio de desarrollo de la tecnopolítica. Por un lado, se evalúa el papel del modelo de toma de decisiones en asamblea -liderazgo horizontal y distribuido-, como parte fundamental del funcionamiento autogestionado. Por otro lado, se estudia la relación entre el compromiso social y político de estas organizaciones y la conexión con los movimientos sociales. El campo de investigación del estudio se centra en los grupos y cooperativas de consumo de la ciudad de Barcelona y su relación con el movimiento 15M acaecido en el año 2011. Los resultados muestran la afinidad ideológica entre las organizaciones y el movimiento que se concreta a través de una participación individual y donde el papel de las TIC es fundamental.
Argentina, Estocolmo, Netflix y el síndrome de la identidad perdida
Authors: Bilbija Ksenija 
Published: September 2018

Aunque la trama principal de la primera serie policial argentina en Netflix Estocolmo: Identidad perdida (2016) gira alrededor de un referente globalizado—la trata de mujeres-- este thriller noir es una producción cultural del neoliberalismo en como manipula el trauma del pasado dictatorial (1976-1983) a través del uso de los símbolos asociados con la memoria histórica argentina. Además, a través del prisma del síndrome de Estocolmo, la serie propone que las mujeres disfrutan y son cómplices de su propia opresión.
Synchronization, oscillator death, and frequency modulation in a class of biologically inspired coupled oscillators
Authors: Franci Alessio , Herrera-Valdez Marco A , Lara-Aparicio Miguel , Padilla-Longoria Pablo 
Published: September 2018

The general purpose of this paper is to build up on our understanding of the basic mathematical principles that underlie the emergence of synchronous biological rhythms, in particular, the circadian clock. To do so, we study the role that the coupling strength, coupling type, and noise play in the synchronization of a system of coupled, nonlinear oscillators. First, we study a deterministic model based on Van der Pol coupled oscillators, modeling a population of diffusively coupled cells, to find regions in the parameter space for which synchronous oscillations emerge and to provide conditions under which diffusive coupling kills the synchronous oscillation. Second, we study how noise and coupling interact and lead to synchronous oscillations in linearly coupled oscillators, modeling the interaction between various pacemaker populations, each having an endogenous circadian clock. To do so, we use the Fokker-Planck equation associated to the system. We show how coupling can tune the frequency of the emergent synchronous oscillation, which provides a general mechanism to make fast (ultradian) pacemakers slow (circadian) and synchronous via coupling. The basic mechanisms behind the generation of oscillations and the emergence of synchrony that we describe here can be used to guide further studies of coupled
oscillations in biophysical nonlinear models.
Association of burnout with doctor–patient relationship and common stressors among postgraduate trainees and house officers in Lahore—a cross-sectional study
Authors: Ahmad Waqas , Ashraf Huma , Talat Afnan , Khan Aleena Ahmad , Baig Ammad Anwar , Zia Iqra , Sarfraz Zohak , Sajid Hifsa , Tahir Marium , Sadiq Usman , Imtiaz Hira 
Published: September 2018

Introduction
Burnout is defined as a prolonged state of physical and psychological exhaustion. Doctors, due to the demanding nature of their job, are susceptible to facing burnout, which has far reaching implications on their productivity and motivation. It affects the quality of care they provide to patients, thus eroding the doctor–patient relationship which embodies patient centeredness and autonomy. The study aims at addressing the stressors leading to burnout and its effect on the doctor–patient relationship.

Methods
A descriptive, cross-sectional study design with convenience (non-probability) sampling technique was employed in six major hospitals of Lahore, Pakistan. A total of 600 doctors were approached for the study which included house officers or “HOs” (recent graduates doing their 1 year long internship) and post-graduate trainees or “PGRs” (residents for 4–5 years in their specialties). Burnout was measured using the Copenhagen Burnout Inventor (CBI) while attitudes towards the doctor–patient relationship was measured using the Patient Practitioner Orientation Scale (PPOS), which measures two components of the relationship: power sharing and patient caring. Pearson correlation and linear regression analysis were used to analyze the data via SPSS v.21.

Results
A total of 515 doctors consented to take part in the study (response rate 85.83%). The final sample consisted of 487 doctors. The burnout score was not associated with the total and caring domain scores of PPOS (P > 0.05). However, it was associated with the power sharing sub-scale of PPOS. Multiple linear regression analysis yielded a significant model, by virtue of which CBI scores were positively associated with factors such as female gender, feeling of burn out, scoring high on sharing domain of PPOS and a lack of personal control while CBI scores were negatively associated with private medical college education, having a significant other, accommodation away from home and a sense of never ending competition. Burnout levels varied significantly between house officers and post graduate trainees. Twenty-three percent of the participants (mostly house officers) had high/very high burnout levels on the CBI (Kristenson’s burnout scoring). Both groups showed significant differences with respect to working hours, smoking status and income.

Conclusion
Although burnout showed no significant association with total and caring domain scores of PPOS (scale used to assess doctor–patient relationship), it showed a significant association with the power sharing domain of PPOS suggesting some impact on the overall delivery of patient care. Thus, it necessitates the monitoring of stressors in order to provide an atmosphere where patient autonomy can be practiced.
Aging and APOE‐ε4 are determinative factors of plasma Aβ42 levels
Authors: Nakamura Takumi , Kawarabayashi Takeshi , Seino Yusuke , Hirohata Mie , Nakahata Naoko , Narita Sakiko , Itoh Ken , Nakaji Shigeyuki , Shoji Mikio 
Published: September 2018

AbstractObjectiveThe aim of this study was to confirm determinative factors for plasma Aβ and its association with cognitive function.MethodsFasting plasma Aβ40 and Aβ42 levels were measured by ELISA in 1019 participants in the Iwaki Health Promotion Project. The relationships between plasma Aβ and health‐related items, including physical characteristics, cognitive function tests, blood chemistry, and APOE‐ε4 genotype were analyzed.ResultsThe plasma levels of Aβ40 and Aβ42, and Aβ40/42 ratio were found to significantly increase with aging. The age‐dependent increase in Aβ42 level was significantly suppressed by APOE‐ε4. Renal function was an associated factor for the plasma Aβ40 level. The plasma Aβ42 level and Aβ40/42 ratio correlated with cognitive function.InterpretationAge and APOE‐ε4 are major determinative factors of plasma levels of Aβ42 and the Aβ40/42 ratio. These factors are critical adjustment factors for the usage of plasma Aβ as a biomarker of central nervous system amyloidosis.
Psoriatic Arthritis Disease Activity During and After Pregnancy: A Prospective Multicenter Study
Authors: Ursin Kristin , Lydersen Stian , Skomsvoll Johan F. , Wallenius Marianne 
Published: September 2018

ObjectiveTo study disease activity in women with peripheral psoriatic arthritis (PsA) during and after pregnancy. Previous knowledge on this topic is sparse.MethodsThe study included 108 pregnancies in 103 women with PsA from a Norwegian nationwide register. Disease activity was assessed prospectively at 7 time points before, throughout, and after pregnancy with the 3‐variable Disease Activity Score in 28 joints (DAS28) using C‐reactive protein levels and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Scores assessed at each time point were analyzed in a linear mixed model. We did additional analyses with “tumor necrosis factor inhibitor (TNFi) in pregnancy” as a covariate. The same statistical method was used to study self‐reported physical function, pain, and mental health.ResultsApproximately 75% of the women were in remission or had low disease activity during and after pregnancy according to the DAS28‐CRP score. Although disease activity was altogether stable, we found that it decreased in pregnancy and increased within 6 months postpartum. Disease activity at 6 months postpartum was significantly higher than at 6 weeks postpartum (mean DAS28‐CRP score 2.71 versus 2.45; P = 0.016). Women using TNFi in pregnancy had significantly lower disease activity than women not using TNFi (mean DAS28‐CRP score at 6 months postpartum 2.22 versus 2.72; P = 0.043). BASDAI scores were also low and stable during pregnancy but significantly higher at 6 months postpartum than at 6 weeks postpartum (mean BASDAI score 3.69 versus 2.95; P = 0.013).ConclusionStudying women with PsA, we found that disease activity was highest at 6 months postpartum but altogether low and stable in the period from planning pregnancy to 1 year after delivery. Women using TNFi in pregnancy had significantly lower disease activity.
Data‐driven approach for fault detection and isolation in nonlinear system
Authors: Kallas Maya , Mourot Gilles , Maquin Didier , Ragot José 
Published: September 2018

SummarySystem diagnosis has been of a great interest for all aspects of industrial processes more precisely to gain in quality. It is based essentially on the analysis of the links between the variables of a system and more precisely on the changes of the relations between these variables, which testify to the presence of faults or anomalies. For that purpose, data modeling is the process of finding a mathematical expression that provides a good fit between given finite sample values of the independent variables and the associated values of the dependent variables of the process.The aim of this paper is to detect and, above all, localize faults affecting a system with nonlinear behavior, when its model is not known a priori. An important part of the presentation is dedicated to the construction of fault indicators capable of locating faults, ie, recognizing the input or output of a system affected by a fault. The first part of this paper is devoted to how to predict the output of a nonlinear behavior system. The second part proposes a way for the detection and isolation of measurement faults based on the proposed prediction model. The relevance of the proposed technique, for modeling and system diagnosis, is illustrated on a simulated example in the context of SIMO and MIMO systems.
Raised serum cystatin C can be a potential biomarker of frailty detected by cumulative deficit model
Authors: Gunasekaran Venugopalan , Dey Sharmistha , Chakrawarty Avinash , Chatterjee Prashun , Sati Hem Chandra , Dwivedi Sada Nand , Dey Aparajit Ballav 
Published: September 2018

AbstractObjectiveIdentification of frailty by clinical criteria is often delayed to the advanced stage. A reliable biomarker to identify frailty or its risk does not currently exist. We aimed to determine the association between serum cystatin C and frailty in subjects without renal dysfunction.MethodsWe carried out a cross‐sectional observational study in the Department of Geriatric Medicine, All India Institute of Medical Sciences, New Delhi, India. The study involved 125 participants, aged 65 years or older. Frailty status was assessed with Frailty Index criteria (cumulative deficit model). Serum cystatin C was estimated with the nephelometry method and its association with frailty was analyzed.ResultsMean age of the study sample was 76.32 years with 72 (57.6%) male and 53 (42.4%) female participants. Seventy‐three subjects were frail; the mean cystatin C levels in the frail and non‐frail groups were 1.28 mg/L (±0.39) and 1.12 mg/L (±0.27), respectively, and the difference was significant (P < 0.05). A cutoff of 1.12 mg/L was found to be 60.27% sensitive and 57.69% specific in identification of frailty. Multivariate analysis showed that higher cystatin C level was associated with 2.52 (1.05‐6.02) times the risk of being frail.ConclusionHigher levels of cystatin C were found in frail subjects. Cystatin C seems to be a promising marker for identifying frailty in older adults without renal abnormalities.
The daily grind: Sex‐ and age‐related activity patterns inferred from cross‐sectional geometry of long bones in a pre‐Columbian muisca population from Tibanica, Colombia
Authors: Miller Melanie J. , Agarwal Sabrina C. , Aristizabal Lucero , Langebaek Carl 
Published: September 2018

AbstractObjectivesDaily activities involve biomechanical strains acting on skeletal structures. This study identifies differences in activity patterns between males and females, and between young, middle, and older aged individuals within an excavated Muisca skeletal sample from the Eastern Andes region of Northern South America.Materials and methodsThe Tibanica archaeological site (AD 1000‐1400) is located at 2600 masl on the Sabana de Bogotá, Colombia. Cross‐sectional geometric analysis of femurs from 63 individuals and paired‐humerii from 33 individuals was used to examine bone size (TA), strength (J) and diaphyseal shape (Imax/Imin, Ix/Iy).ResultsThe findings indicate both age‐ and sex‐related differences in activity patterns. An emphasis on upper body strength and robusticity was observed in the females, while males performed more strenuous work using their lower bodies, suggesting gender‐based differences in labor. Men showed significant asymmetry in their humerii, with most showing right‐hand dominance for upper body activities, while females showed high levels of humeral symmetry indicating similar levels of biomechanical stress for both arms. Female femoral diaphyseal shape changes with age, suggesting more mobility in youth and decreased mobility in middle and older ages.DiscussionThese results suggest that daily life may have been structured through patterns of routine labor that united and divided particular age and sex groups. Cross‐sectional geometry data indicate women likely spent significant time and energy preparing food, especially grinding maize or other foods, while men may have done more long‐distance walking potentially to work in agricultural fields or procure other resources.
Katalytische, isofunktionelle Reaktionen – Erweiterung des Repertoires an Shuttle‐ und Metathesereaktionen
Authors: Bhawal Benjamin N. , Morandi Bill 
Published: September 2018

AbstractTransferhydrierungsreaktionen, genauso wie Metathesereaktionen von Alkenen und Alkinen, sind von großer Bedeutung in der Synthesechemie. Ein gemeinsames Schlüsselmerkmal dieser Verfahren ist ihre Reversibilität, die davon herrührt, dass sowohl Startverbindungen als auch Produkte die gleiche Anzahl und Art von funktionellen Gruppen aufweisen und die Verfahren somit isofunktionell machen. Diese klassischen Reaktionen trugen in letzter Zeit dazu bei, neuartige Shuttle‐ und Metathesereaktionen zu entwickeln, die vielversprechend für die Synthesechemie sein könnten. Dieser Aufsatz beschreibt und ordnet aktuelle wie auch ältere Beispiele von Shuttle‐ und Metathesereaktionen (mit Ausnahme von Transferhydrierungen und Metathesereaktionen von Alkenen und Alkinen).
Dynamic Kinetic Asymmetric Reductive Amination: Synthesis of Chiral Primary β‐Amino Lactams
Authors: Lou Yazhou , Hu Yutao , Lu Jiaxiang , Guan Fanfu , Gong Gelin , Yin Qin , Zhang Xumu 
Published: September 2018

AbstractA highly efficient ruthenium‐catalyzed asymmetric reductive amination (ARA) of racemic β‐keto lactams with molecular hydrogen and ammonium salts is disclosed for the synthesis of enantiomerically pure primary amino lactams through dynamic kinetic resolution (DKR). By this approach, a range of syn primary β‐amino lactams were obtained in high yields with high chemo‐, enantio‐, and diastereoselectivity (up to 98 % yield, 99 % ee, >20:1 d.r., syn products). The utility of the products has been demonstrated by rapid access to a key synthetic intermediate towards biologically active drug molecules. Meanwhile, mechanistic studies and control experiments indicate that the reaction may proceed through the hydrogenation of an iminium intermediate.
Total Syntheses of Asperchalasines A–E
Authors: Bao Ruiyang , Tian Chong , Zhang Haoyu , Wang Zhiguo , Dong Zhen , Li Yuanhe , Gao Mohan , Zhang Haolin , Liu Gang , Tang Yefeng 
Published: September 2018

AbstractThe first total syntheses of asperchalasines A–E, a collection of unprecedented merocytochalasans, are reported. Aspochalasin B, a key tricyclic cytochalasan monomer, was first synthesized through a unified approach that hinges on a Diels–Alder reaction and a ring‐closing metathesis reaction. The bioinspired Diels–Alder reactions of aspochalasin B with different epicoccine precursors were then explored, which enabled the divergent access of the heterodimers asperchalasines B–E as well as related congeners. Furthermore, the heterotrimer asperchalasine A was obtained from one epicoccine unit and two aspochalasin B units through a biomimetic Diels–Alder reaction followed by an oxidative [5+2]‐cycloaddition.
Enantioselective Functionalization of Enamides at the β‐Carbon Center with Indoles
Authors: Saputra Mirza A. , Nepal Binod , Dange Nitin S. , Du Pu , Fronczek Frank R. , Kumar Revati , Kartika Rendy 
Published: September 2018

AbstractWe report an enantioconvergent approach for the functionalization of enamides at the β‐carbon atom, which involves a chiral Brønsted acid induced tautomerization of 2‐amidoallyl into 1‐amidoallyl cations. These putative reactive intermediates were produced by ionization of racemic α‐hydroxy enamides with a chiral Brønsted acid and captured with substituted indoles in a highly regio‐ and enantioselective manner.
Examination of the Deubiquitylation Site Selectivity of USP51 by Using Chemically Synthesized Ubiquitylated Histones
Authors: Ai Huasong , Guo Yu , Sun Demeng , Liu Sanling , Qi Yunkun , Guo Jing , Qu Qian , Gong Qingyue , Zhao Suwen , Li Jiabin , Liu Lei 
Published: September 2018

AbstractHistone ubiquitylation and deubiquitylation processes and the mechanisms of their regulation are closely relevant to the field of epigenetics. Recently, the deubiquitylating enzyme USP51 was reported to selectively cleave ubiquitylation on histone H2A at K13 or K15 (i.e., H2AK13Ub and H2AK15Ub), but not at K119 (i.e., H2AK119Ub), in nucleosomes in vivo. To elucidate the mechanism for the selectivity of USP51, we constructed structurally well‐defined in vitro protein systems with a ubiquitin modification at precise sites. A total chemical protein synthesis procedure was developed, wherein hydrazide‐based native chemical ligation was used to efficiently generate five ubiquitylated histones (H2AK13Ub, H2AK15Ub, H2AK119Ub, H2BK34Ub, and H2BK120Ub). These synthetic ubiquitylated histones were assembled into nucleosomes and subjected to in vitro USP51 deubiquitylation assays. Surprisingly, USP51 did not show preference between H2AK13/15Ub and H2AK119Ub, in contrast to previous in vivo observations. Accordingly, an understanding of the selectivity of USP51 may require consideration of other factors, such as alternative pre‐existing histone modifications, competitive reader proteins, or different nucleosome quality among the in vivo extraction nucleosome and the in vitro reconstitution one. Further experiments established that USP51 in vitro could deubiquitylate a nucleosome carrying H2BK120Ub, but not H2BK34Ub. Molecular dynamics simulations suggested that USP51‐catalyzed hydrolysis of ubiquitylated nucleosomes was affected by steric hindrance of the isopeptide bond.
A Photoenzymatic NADH Regeneration System
Authors: Höfler Georg T. , Fernández‐Fueyo Elena , Pesic Milja , Younes Sabry H. , Choi Eun‐Gyu , Kim Yong H. , Urlacher Vlada B. , Arends Isabel W. C. E. , Hollmann Frank 
Published: September 2018

AbstractA photoenzymatic NADH regeneration system was established. The combination of deazariboflavin as a photocatalyst with putidaredoxin reductase enabled the selective reduction of NAD+ into the enzyme‐active 1,4‐NADH to promote an alcohol dehydrogenase catalysed stereospecific reduction reaction. The catalytic turnover of all the reaction components was demonstrated. Factors influencing the efficiency of the overall system were identified.
A Sustainable Method for the Synthesis of Acetic Acid Based on Dehydrogenation of an Ethanol–Water Solution Catalyzed by an Iridium Complex Bearing a Functional Bipyridonate Ligand
Authors: Kuwahara Masato , Nishioka Masaaki , Yoshida Masato , Fujita Ken‐ichi 
Published: September 2018

AbstractThe front cover artwork for issue 17/2018 is provided by Prof. Ken‐ichi Fujita′s group from Kyoto University, Japan. The image shows the synthesis of acetic acid via dehydrogenation of a mixture of ethanol and water using a new iridium catalyst bearing a functional bipyridonate ligand with N,N‐dimethylamino substituents. See the Communication itself at https://doi.org/10.1002/cctc.201800680.
Ectonucleotidase Inhibitory and Redox Activity of Imidazole‐Based Organic Salts and Ionic Liquids
Authors: Boldescu Veaceslav , Sucman Natalia , Hassan Sidra , Iqbal Jamshed , Neamtu Mariana , Lecka Joanna , Sévigny Jean , Prodius Denis , Macaev Fliur 
Published: September 2018

AbstractCytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole‐based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1‐methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK‐21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen.