bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parallel stent grafts for the treatment of complex aortic aneurysms: A single center study
Authors: Silverberg Daniel , Rimon Uri , Raskin Daniel , BarDayan Avner , Halak Moshe 
Published: March 2018

Background “Chimney” techniques with parallel grafts used in order to extend the landing zones in endovascular aneurysm repair (ch-EVAR) are increasingly being reported. Conflicting data has been reported regarding the success and durability of the repair. We report a single center experience using ch-EVAR in treating complex aortic pathologies. Methods We performed a retrospective review of all patients treated with ch-EVAR in our institution between 2013 and 2017. Data collected included patients demographics, indications for surgery, configuration of parallel grafts, technical success, and perioperative morbidity and mortality. Follow-up data included aortic sac size, reintervention rate, and overall mortality. Results Thirty-five patients underwent treatment of their aneurysms with parallel grafts. Sixty parallel grafts were placed. Mean age was 75 years (range 59–93) and 30 (85%) were male. Technical success was achieved in 32 (91%) patients. Mean follow up was 12 months. Sac size decreased in diameter or remained unchanged in 26 of the 30 (86.6%) patients. Four patients were found to have enlarging aneurysms due to gutter endoleaks. All were treated successfully with endovascular methods. The estimated primary patency was 95% at 12 months. Probability of freedom from intervention was 75% at 12 months. No late aneurysm related mortality occurred. Conclusion The use of ch-EVAR in treating complex aortic aneurysms is technically feasible and safe. Gutter endoleaks are encountered only in a minority of the cases, and can be treated with minimally invasive techniques. Longer term follow up is required to evaluate the patency of these parallel grafts and the durability of the aneurysm exclusion.
Improving the documentation of flexible cystoscopy notes: Case for introduction of electronic patient records?
Authors: Blach Ola , Ali Ahmed , Bott Simon , Montgomery Bruce 
Published: March 2018

Introduction/Objective: Good surgical practice dictates that comprehensive and legible records are maintained by surgeons of all their interactions with patients. Flexible cystoscopy (FC) notes should be no exception to this standard. Currently at our institution, for every cystoscopy, FC operators document the same information in two different locations: handwritten in patient notes and electronic discharge letter. Methods: A closed-loop audit of FC notes at our institution was undertaken and data were collected prospectively using patients’ notes. Notes were scrutinised against the Royal College of Surgeons (RCS)/British Association of Urological Surgeons (BAUS) standards. The first period was 13–17 October 2015, and the second period was 20–31 May 2016. A total of 73 patients were included (43+30). Results: The first cycle highlighted several areas requiring improvement. Eight of 15 parameters fell short of the 100% target compliance: time (5.9%), responsible consultant (32.4%), operator (50%), postoperative instructions (82.4%), indication for FC (85.3%), date (88.2%), procedure name (91.2%) and signature (97%). Subsequently, a new electronic FC proforma was designed using the RCS/BAUS criteria for data to be documented. A successive re-audit using identical criteria established 100% compliance in all fields. Conclusion: Adopting the new proforma significantly improved the quality of FC documentation. Subsequently, new online software incorporating our proforma was introduced as part of electronic patient records, allowing for data to be easily accessed and read. We discuss the relevance of this in the context of existing literature. Level of evidence: Not applicable for this multicentre audit.
Mammary fibroadenomatous hyperplasia in a male cat
Authors: Mayayo Saray Lorna , Bo Stefano , Pisu Maria Carmela 
Published: March 2018

Case summary Mammary fibroadenomatous hyperplasia (MFH) is a benign pathology characterised by extensive proliferation of the ductal epithelium and mammary stroma. It typically occurs in young female cats, and seems to result from hypersensitivity to progesterone. A 2-year-old entire male European Shorthair cat presented to the veterinary clinic with enlargement of several mammary glands, which had developed within the previous 10 days. There was no prior administration of progestin in the cat’s medical history. Diagnostic tests were performed to assess the basal progesterone concentration and the concentration after stimulation with gonadotropin-releasing hormone, which ruled out the presence of functional ovarian tissue. Histological examination of the testes excluded hormone-secreting testicular tumours. Histological examination of the mammary gland confirmed the diagnosis of MFH. Treatment was started with aglepristone, a selective competitor for progesterone receptors, administered subcutaneously at 15 mg/kg at days 1, 2, 8 and 15. A reduction in the size of the mammary glands was evident 6 days after the first administration, with complete remission observed after 4 weeks. Relevance and novel information To the best of our knowledge, this is the first full report of MFH in a male cat. Although the origin of the progestins responsible for MFH in this case could not be confirmed, in the light of the diagnostic tests performed and the results obtained, accidental contact with hormone-like substances seems to be the only plausible explanation for the cat’s clinical signs. Inhibitor therapy was successful.
Growth of the colon and rectum throughout gestation: evaluation with fetal MRI
Authors: Ben-Nun Michalle Soudack , Ben-Shlush Aviva , Raviv Zilka Lisa 
Published: March 2018

Background Congenital abnormalities of the gastrointestinal tract are increasingly being evaluated by prenatal magnetic resonance imaging (MRI). However, there is a paucity of reports describing the normal quantitative development of the fetal colon and rectum on MRI. Purpose To provide growth curves of the MRI estimated diameter of the fetal colon and rectum as a function of gestational age. Material and Methods This is a retrospective review of 191 singleton fetal MRI studies at 25–39 weeks of gestation. Measurements included maximal diameter of the ascending, transverse, and descending colon on coronal and sagittal views, maximal diameter of the rectum on coronal and sagittal views, and maximal diameter of the rectum at the level of the bladder base on sagittal views. Median growth curves were built using a generalized additive model. Confidence regions were built for 10th, 25th, 75th, and 90th percentiles. Results Smoothed growth curves for the median, and one and three quartiles for each of the five sections as a function of gestational age were calculated. All graphs had a slightly exponential curve. Conclusion This study provides normal ranges of the prenatal colon and rectum as a function of gestational age. They may serve as reference values when interpreting fetal MRI.
Coagulopathy induced by traumatic brain injury: systemic manifestation of a localized injury
Authors: Zhang Jianning , Zhang Fangyi , Dong Jing-fei 
Published: March 2018

AbstractTraumatic brain injury (TBI)–induced coagulopathy is a common and well-recognized risk for poor clinical outcomes, but its pathogenesis remains poorly understood, and treatment options are limited and ineffective. We discuss the recent progress and knowledge gaps in understanding this lethal complication of TBI. We focus on (1) the disruption of the brain-blood barrier to disseminate brain injury systemically by releasing brain-derived molecules into the circulation and (2) TBI-induced hypercoagulable and hyperfibrinolytic states that result in persistent and delayed intracranial hemorrhage and systemic bleeding.
Five-year outcomes for frontline brentuximab vedotin with CHP for CD30-expressing peripheral T-cell lymphomas
Authors: Fanale Michelle A. , Horwitz Steven M. , Forero-Torres Andres , Bartlett Nancy L. , Advani Ranjana H. , Pro Barbara , Chen Robert W. , Davies Andrew , Illidge Tim , Uttarwar Mayur , Lee Shih-Yuan , Ren Hong , Kennedy Dana A. , Shustov Andrei R. 
Published: March 2018

Key Points
100% response rate (92% CR) in 26 patients treated with frontline BV+CHP. After ∼5 years, 50% remained in CR (PFS 37.8+ to 66.0+ months). 18 of 19 patients (95%) with treatment-emergent PN reported resolution or improvement in symptoms; 9 had resolution of all PN events.
Role of survey response rates on valid inference: an application to HIV prevalence estimates
Authors: Marino Miguel , Pagano Marcello 
Published: March 2018

Abstract
Background

Nationally-representative surveys suggest that females have a higher prevalence of HIV than males in most African countries. Unfortunately, these results are made on the basis of surveys with non-ignorable missing data. This study evaluates the impact that differential survey nonresponse rates between males and females can have on the point estimate of the HIV prevalence ratio of these two classifiers.

Methods
We study 29 Demographic and Health Surveys (DHS) from 2001 to 2010. Instead of employing often used multiple imputation models with a Missing at Random assumption that may not hold in this setting, we assess the effect of ignoring the information contained in the missing HIV information for males and females through three proposed statistical measures. These measures can be used in settings where the interest is comparing the prevalence of a disease between two groups. The proposed measures do not utilize parametric models and can be implemented by researchers of any level. They are: (1) an upper bound on the potential bias of the usual practise of using reported HIV prevalence estimates that ignore subjects who have missing HIV outcomes. (2) Plausible range intervals to account for nonresponses, without any additional parametric modeling assumptions. (3) Prevalence ratio inflation factors to correct the point estimate of the HIV prevalence ratio, if estimates of nonresponders’ HIV prevalences were known.

Results
In 86% of countries, males have higher upper bounds of HIV prevalence than females, this is consonant with males possibly having higher infection rates than females. Additionally, 74% of surveys have a plausible range that crosses 1.0, suggesting a plausible equivalence between male and female HIV prevalences.

Conclusions
It is quite reasonable to conclude that there is so much DHS nonresponse in evaluating the HIV status question, that existing data is plausibly generated by the situation where the virus is equally distributed between the sexes.
Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis
Authors: Mustonen Antti , Niemelä Solja , Nordström Tanja , Murray Graham K. , Mäki Pirjo , Jääskeläinen Erika , Miettunen Jouko 
Published: March 2018

BackgroundThe association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial.AimsTo examine the association between cannabis use in adolescence and the risk of psychosis after adjustment for prodromal symptoms and other potential confounders.MethodThe sample (n = 6534) was composed of the prospective general population-based Northern Finland Birth Cohort of 1986. Information on prodromal symptoms of psychosis and cannabis use was collected using questionnaires at age 15–16 years. Participants were followed up for ICD-10 psychotic disorders until age 30 years using nationwide registers.ResultsThe risk of psychosis was elevated in individuals who had tried cannabis five times or more (hazard ratio, (HR) = 6.5, 95% CI 3.0–13.9). The association remained statistically significant even when adjusted for prodromal symptoms, other substance use and parental psychosis (HR = 3.0, 95% CI 1.1–8.0).ConclusionsAdolescent cannabis use is associated with increased risk of psychosis even after adjustment for baseline prodromal symptoms, parental psychosis and other substance use.Declaration of interestNone.
Efficient Praziquantel Encapsulation into Polymer Microcapsules and Taste Masking Evaluation Using an Electronic Tongue
Authors: Machado Jaison C , Shimizu Flavio M , Ortiz Manoel , Pinhatti Marina S , Carr Olivia , Guterres Silvia S , Oliveira Osvaldo N , Volpato Nadia M 
Published: March 2018

Abstract
Taste masking is an important strategy for improving adherence of patients, especially children, who have to take pharmaceutical drugs with a bitter taste, as is the case of praziquantel (PZQ) used to treat schistosomiasis. In this work, a modified interfacial polymer deposition method was used to prepare polymer microcapsules and microspheres to encapsulate PZQ, where formulations were optimized to fulfill the stringent requirements for controlled drug release. In vitro release tests confirmed the suitability of the formulation with microcapsules of the anionic copolymer L30D, in which the loading of PZQ was larger than 90% in solutions that were stable at low pH but released PZQ under enteric conditions. We also show that the encapsulation was effective in terms of masking PZQ taste through the analysis with an electronic tongue.
Reflections on the use of the World Health Organization’s (WHO) OneHealth Tool: Implications for health planning in low and middle income countries (LMICs)
Authors: Wong John Q. , Haw Nel Jason , Uy Jhanna , Bayani Diana Beatriz 
Published: March 2018

The World Health Organization (WHO) launched the OneHealth Tool (OHT) to help low and middle income countries to develop their capacities for sector-wide priority setting. In 2016, we sought to use the OHT to aid the Philippine Health Insurance Corporation (PHIC), the national health insurer of the Philippines, in decisions to expand benefit packages using cost-effectiveness analyses. With technical support from the WHO, we convened health planning officers from the Philippine Department of Health (DOH) and the Philippine Health Insurance Corporation (PHIC) conduct generalized cost-effective analyses (GCEA) of selected un-financed noncommunicable disease interventions using OHT. We collected epidemiological and cost data through health facility surveys, review of literature such as cost libraries and clinical practice guidelines, and expert consultations. Although we were unable to use GCEA results directly to set policy, we learnt important policy lessons which we outline here that might help inform other countries looking to inform service coverage decisions. Additionally, the entire process and GCEA visualizations helped high-level policymakers in the health sector, who have traditionally relied on ad hoc decision making, to realize the need for a systematic and transparent priority-setting process that can continuously provide the evidence needed to inform service coverage decisions.
Comparing the cost-per-QALYs gained and cost-per-DALYs averted literatures
Authors: Neumann Peter J. , Anderson Jordan E. , Panzer Ari D. , Pope Elle F. , D'Cruz Brittany N. , Kim David D. , Cohen Joshua T. 
Published: March 2018

Background: We examined the similarities and differences between studies using two common metrics used in cost-effectiveness analyses (CEAs): cost per quality-adjusted life year (QALY) gained and cost per disability-adjusted life year (DALY) averted.Methods: We used the Tufts Medical Center CEA Registry, which contains English-language cost-per-QALY gained studies, and the Global Cost-Effectiveness Analysis (GHCEA) Registry, which contains cost-per-DALY averted studies. We examined study characteristics, including intervention type, sponsor, country, and primary disease, and also compared the number of published CEAs to disease burden for major diseases and conditions across geographic regions.Results: We identified 6,438 cost-per-QALY and 543 cost-per-DALY studies published through 2016 and observed rapid growth for both literatures. Cost-per-QALY studies most often examined pharmaceuticals and interventions in high-income countries. Cost-per-DALY studies predominantly focused on infectious disease interventions and interventions in low and lower-middle income countries. We found that while diseases imposing a larger burden tend to receive more attention in the cost-effectiveness analysis literature, the number of publications for some diseases and conditions deviates from this pattern, suggesting “under-studied” conditions (e.g., neonatal disorders) and “over-studied” conditions (e.g., HIV and TB).Conclusions: The CEA literature has grown rapidly, with applications to diverse interventions and diseases. The publication of fewer studies than expected for some diseases given their imposed burden suggests funding opportunities for future cost-effectiveness research.
Evaluating the performance of tools used to call minority variants from whole genome short-read data
Authors: Said Mohammed Khadija , Kibinge Nelson , Prins Pjotr , Agoti Charles N. , Cotten Matthew , Nokes D.J. , Brand Samuel , Githinji George 
Published: March 2018

Background: High-throughput whole genome sequencing facilitates investigation of minority sub-populations from virus positive samples. Minority variants are useful in understanding within and between host diversity, population dynamics and can potentially help to elucidate person-person transmission chains. Several minority variant callers have been developed to describe the minority variants sub-populations from whole genome sequence data. However, they differ on bioinformatics and statistical approaches used to discriminate sequencing errors from low-frequency variants. Methods: We evaluated the diagnostic performance and concordance between published minority variant callers used in identifying minority variants from whole-genome sequence data. The ART-Illumina read simulation tool was used to generate three artificial short-read datasets of varying coverage and error profiles from an RSV reference genome. The datasets were spiked with nucleotide variants at predetermined positions and frequencies. Variants were called using FreeBayes, LoFreq, Vardict, and VarScan2. The variant callers’ agreement in identifying known variants was quantified using two measures; concordance accuracy and the inter-caller concordance. Results: The variant callers reported differences in identifying minority variants from the datasets. Concordance accuracy and inter-caller concordance were positively correlated with sample coverage. FreeBayes identified majority of the variants although it was characterised by variable sensitivity and precision in addition to a high false positive rate relative to the other minority variant callers and which varied with sample coverage. LoFreq was the most conservative caller. Conclusions: We conducted a performance and concordance evaluation of four minority variant calling tools used to identify and quantify low frequency variants. Inconsistency in the quality of sequenced samples impact on sensitivity and accuracy of minority variant callers. Our study suggests that combining at least three tools when identifying minority variants is useful in filtering errors when calling low frequency variants.
POR QUE (DES)LER OS CLÁSSICOS EM OMEROS?
Authors: Botelho Marcos Cezar 
Published: March 2018

O artigo discute o romance Omeros de Derek Walcott a partir das seguintes perguntas: É realmente possível falar a respeito de uma poética pós-colonial? Quais são as suas estratégias e perspectivas enunciativas?
Imagens inaugurais e cenas urbanas: recorrências identitárias em Meu querido canibal
Authors: Pereira Elvya Ribeiro 
Published: March 2018

A capa do livro Meu querido canibal (Antônio Torres, 2000), assinada pelo artista gráfico Noguchi, traz uma sugestiva leitura do romance, tanto na sua epresentação plástica, como no título – “A imagem da falsa guarda”. O capista apresenta uma imagem conceitual que diz da natureza da narrativa no que ela joga com deslizamentos retóricos e ideológicos em torno da colonização. A capa revela uma instável sagração da natureza, elevando o índio a uma posição de herói em guarda, à espera de um inimigo ainda fora da paisagem. As estruturas narrativas do romance são configuradas num jogo de espelhamentos discursivosque acionam dados históricos documentais, como também, molduras subjetivas, imaginárias ou ficcionais.Esse jogo de perspectivas parece manipulado por um narrador em trânsito, que recolhe “alfarrábios” e dissemina paráfrases e paródias e que está implicado na sua própria teia de referências e representações, ou seja, é ele próprio um documento vivo que, ao mergulhar nos vestígios do passado, submerge também nas franjas de um tempo que se enreda em caóticas cenas urbanas.
ECOS GLAUBERIANOS no cinema sul-africano
Authors: Do Nascimento Neto João Evangelista 
Published: March 2018

A película Deus e o Diabo na terra do sol, de Glauber Rocha, dialoga, nesse estudo, com a obra fílmica Infância Roubada, do sul-africano Gavin Hood, a fim de analisar, por entre claves e tons, a influência da obra brasileira na trilha sonora do filme realizado na África do Sul. A música no filme tem, como objetivo primordial, a função de contar a história, contribuindo para que o espectadorcompreenda a narrativa. Em Deus e o Diabo, ela, de cunho popular, ganha notoriedade ao ser posta em diálogo com a música erudita. Em Infância Roubada, a música representa a voz e os anseios de uma população marginalizada. Desse modo, por meio do viés da estética da fome e da violência, e apropriando-se dos acordes teóricos de Berchmans (2006), Novaes (2007), Souza (2009), Stam (2003), Valentinetti (2002) e Xavier (1983), dentre outros, o cinema brasileiro baila com o sul-africano ao som de canções que significam e simbolizam o ser humano em convívio consigo mesmo e com seus semelhantes.
SERTÕES DAS LETRAS ao cinema nacional: Pedra Bonita e Cangaceiros em Deus e o Diabo na Terra do Sol
Authors: Silva Leandro 
Published: March 2018

O presente artigo trabalha a relação entre O ciclo do misticismo e do cangaço,fase em que José Lins do Rego traz a lume os livros Pedra Bonita e Cangaceiros no constructo de Deus e o Diabo de Glauber Rocha, a partir da perspectiva de que, tanto as narrativas literárias, como o filme, à guisa do realismo documental que marca o Cinema Novo e o Modernismo, extenuam a busca por uma identidade nacional, a partir dos resgaste do mitos sertanejos, detidamente o cangaço e o beatismo.
GLAUBER ROCHA, intérprete farol da imaginação
Authors: Botelho Marcos Cezar 
Published: March 2018

O objetivo deste roteiro é comentar passagens de filmes e posicionamentos estéticos do cineasta-pensador Glauber Rocha. Tais fragmentos são lidos como fachos de uma “obra farol” fundamentais à hermenêutica da nacionalidade e modernidade brasileiras. Do conceito de “estrutura de sentimento” proposto por Raymond Williams, vem a hipótese de que a geração do cineasta, a“Fração da Avant-Garde Baiana”, nas esquinas das décadas de 1950 e 1960, inventou dois dos mais importantes movimentos da cultura brasileira, a Tropicália e o Cinema Novo, relendo os clássicos de interpretação da nação em diálogo com as informações das vanguardas artísticas europeias. Analisam-se as conversas entre a obra glauberiana e Os Sertões, de Euclides da Cunha, e a importância que o livro de Euclides exerceu no Bildung intelectual de Glauber Rocha.
CORDEL, cinema & Glauber
Authors: Debs Sylvie 
Published: March 2018

Este artigo se propõe a analisar dois filmes de Glauber Rocha, Deus e o Diabo na Terra do Sol e O Dragão da Maldade contra o Santo Guerreiro à luz dos elementos do universo da cultura popular nordestina admitidos como a inspiração pelo cineasta para criar a estética do cinema novo, tanto do ponto-de-vista da trama e da escolha dos personagens, das performances gestuais, da narração, da música, da luz e da fotografia, quanto do conteúdo religioso, social e político; desta forma, Glauber Rocha parte de uma realidade regional para a projetar num plano nacional e internacional.