bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Politics of Emotions and Spectacles: The Case of the Turkish Language Olympiads
Authors: Aslan Senem 
Published: October 2019

AbstractThis article examines the Turkish Language Olympiads as a political-performative strategy that the Muslim nationalists used to communicate their ideology. I argue that to understand the rise of Muslim nationalism, we also need to understand how emotional appeal is created through spectacles like the Turkish Olympiads. The spectacle was effective in boosting people’s sense of national pride and self-confidence by resolving two important tensions of Kemalist nationalism. First, it addressed the tension between Westernization and nationalization. Depicting an image of Turkish national culture that is appreciated and imitated by foreigners, it contested the imitative, Westernist character of Kemalist nationalism. Second, recasting the outside world as friendly to Turks, even Turkophile, it challenged Kemalist nationalism’s emphasis on external threats. Turkish-speaking and -acting foreigners communicated a message of nationalist self-empowerment and confidence, calling into question people’s sense of fear and distrust of the outside world. How Muslim nationalism was promoted, particularly the performative-symbolic strategies that were used, are important to understand because of their emotional resonance and potential for mass mobilization.
Plasma polyphenols associated with lower high-sensitivity C-reactive protein concentrations: a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
Authors: Harms Laura M. , Scalbert Augustin , Zamora-Ros Raul , Rinaldi Sabina , Jenab Mazda , Murphy Neil , Achaintre David , Tjønneland Anne , Olsen Anja , Overvad Kim , Romana Mancini Francesca , Mahamat-Saleh Yahya , Boutron-Ruault Marie-Christine , Kühn Tilman , Katzke Verena , Trichopoulou Antonia , Martimianaki Georgia , Karakatsani Anna , Palli Domenico , Panico Salvatore , Sieri Sabina , Tumino Rosario , Sacerdote Carlotta , Bueno-de-Mesquita Bas , Vermeulen Roel C. H. , Weiderpass Elisabete , Nøst Therese Haugdahl , Lasheras Cristina , Rodríguez-Barranco Miguel , Huerta José María , Barricarte Aurelio , Dorronsoro Miren , Hultdin Johan , Schmidt Julie A. , Gunter Marc , Riboli Elio , Aleksandrova Krasimira 
Published: October 2019

AbstractExperimental studies have reported on the anti-inflammatory properties of polyphenols. However, results from epidemiological investigations have been inconsistent and especially studies using biomarkers for assessment of polyphenol intake have been scant. We aimed to characterise the association between plasma concentrations of thirty-five polyphenol compounds and low-grade systemic inflammation state as measured by high-sensitivity C-reactive protein (hsCRP). A cross-sectional data analysis was performed based on 315 participants in the European Prospective Investigation into Cancer and Nutrition cohort with available measurements of plasma polyphenols and hsCRP. In logistic regression analysis, the OR and 95 % CI of elevated serum hsCRP (>3 mg/l) were calculated within quartiles and per standard deviation higher level of plasma polyphenol concentrations. In a multivariable-adjusted model, the sum of plasma concentrations of all polyphenols measured (per standard deviation) was associated with 29 (95 % CI 50, 1) % lower odds of elevated hsCRP. In the class of flavonoids, daidzein was inversely associated with elevated hsCRP (OR 0·66, 95 % CI 0·46, 0·96). Among phenolic acids, statistically significant associations were observed for 3,5-dihydroxyphenylpropionic acid (OR 0·58, 95 % CI 0·39, 0·86), 3,4-dihydroxyphenylpropionic acid (OR 0·63, 95 % CI 0·46, 0·87), ferulic acid (OR 0·65, 95 % CI 0·44, 0·96) and caffeic acid (OR 0·69, 95 % CI 0·51, 0·93). The odds of elevated hsCRP were significantly reduced for hydroxytyrosol (OR 0·67, 95 % CI 0·48, 0·93). The present study showed that polyphenol biomarkers are associated with lower odds of elevated hsCRP. Whether diet rich in bioactive polyphenol compounds could be an effective strategy to prevent or modulate deleterious health effects of inflammation should be addressed by further well-powered longitudinal studies.
Impact of Ramadan diurnal intermittent fasting on the metabolic syndrome components in healthy, non-athletic Muslim people aged over 15 years: a systematic review and meta-analysis
Authors: Faris ‘Mo’ez Al-Islam’ E. , Jahrami Haitham A. , Alsibai Joud , Obaideen Asma A. 
Published: October 2019

AbstractStudies on the impact of Ramadan diurnal intermittent fasting (RDIF) on the metabolic syndrome (MetS) components among healthy Muslims observing Ramadan month have yielded contradictory results. This comprehensive meta-analysis aimed to obtain a more stable estimate of the effect size of fasting during Ramadan on the MetS components, examine variability among studies, assess the generalisability of reported results and perform subgroup analyses for associated factors. We searched the CINAHL, Cochrane, EBSCOhost, Google Scholar, ProQuest Medical, PubMed/MEDLINE, ScienceDirect, Scopus and Web of Science databases for relevant studies published from 1950 to March 2019. The MetS components analysed were: waist circumference (WC), systolic blood pressure (SBP), fasting plasma/serum glucose (FG), TAG, and HDL-cholesterol. We identified eighty-five studies (4326 participants in total) that were conducted in twenty-three countries between 1982 and 2019. RDIF-induced effect sizes for the MetS components were: small reductions in WC (no. of studies K = 24, N 1557, Hedges’ g = −0·312, 95 % CI −0·387, −0·236), SBP (K = 22, N 1172, Hedges’ g = −0·239, 95 % CI −0·372, −0·106), FG (K = 51, N 2318, Hedges’ g = −0·101, 95 % CI −0·260, 0·004) and TAG (K = 63, N 2862, Hedges’ g = −0·088, 95 % CI −0·171, −0·004) and a small increase in HDL-cholesterol (K = 57, N 2771, Hedges’ g = 0·150, 95 % CI 0·064, 0·236). We concluded that among healthy people, RDIF shows small improvement in the five MetS components: WC, SBP, TAG, FG and HDL.
A new species ofHedruris(Nematoda: Hedruridae) from freshwater turtles, its life cycle and biogeographic distribution of the genus
Authors: Palumbo E. , Servián A. , Sánchez R. , Diaz J.I. 
Published: October 2019

AbstractWe describeHedruris dratinin. sp. (Nematoda, Hedruridae) fromHydromedusa tectiferaandPhrynops hilariiin Argentina based on morphological and molecular characters. Also, we provide information about its life cycle. The new species differs from other species of the genus by possessing the excretory pore, nerve ring and deirids at equal distance from the anterior end. Additionally,H. dratinin. sp. has mammilated eggs and males possess nine pairs of caudal papillae. The subadults and adults ofH. dratinin. sp andH. orestiaewere characterized by sequencing the small subunit ribosomal DNA (18S). We present for the first time a life cycle of a species ofHedruristhat includes an amphipod as intermediate host and a reptile as definitive host. Furthermore, we analysed the host and geographic distribution of allHedrurisspecies. Although the genus has a cosmopolitan distribution and parasitizes a great host diversity, the majority of species have a Gondwanian distribution, with amphibians being the preferred hosts.
Power in the metropolis: the impact of economic and demographic growth on the Antwerp City Council (1400–1550)
Authors: Everaert Janna 
Published: October 2019

AbstractCurrent historiography endorses a narrative that the political elite of pre-industrial gateway cities became more ‘open’ in the wake of efflorescence and that their city councils became populated with merchants. Yet, according to the existing literature, Antwerp challenges this narrative, as the influx of merchants was very limited during late fifteenth and early sixteenth centuries when Antwerp transformed from a medium-sized Brabantine city into the leading economic centre in western Europe. Moreover, scholars disagree on whether the economic expansion had any impact at all on the composition and profile of Antwerp's political elite. By analysing the social composition of the city council and how this evolved from the beginning of Antwerp's commercial expansion around 1400 until its apogee around 1550, I revisit the question whether Antwerp constitutes an exception to the established pattern of elite formation in gateway cities and, if so, why.
Pain drawings, interpreter support and clinical findings among immigrant patients on sick leave in Swedish primary health care
Authors: Löfvander Monica 
Published: October 2019

AbstractAim:To evaluate the spread of pain and its correlates among immigrant patients on sick leave.Background:Backache, outspread pain and sick-leave questions are problematic to handle primary health care, especially in multicultural settings.Methods:Two hundred and thirty-five patients 20–45 years on paid sick leave (59% women, 93% foreign-born, mostly non-Europeans). Many had little formal education. One-third had professional interpreter support. The patients pointed out on their bodies where they felt pain. This information was transferred on a pain drawing [pain drawing fields (PDFs) 0–18] by a doctor. Major depression and psychosocial stressors were assessed usingDiagnostic and Statistical Manual of Mental Disorders. Nociceptive locations for pain were established (pain-sites 0–18). Dependent variable was the number of PDFs. Independent variables were social data, sick leave, interpreter, depression, stress levels and number of pain sites. Calculations were done using descriptive methods and multi-variable linear regression in full models, by gender.Findings:Many patients had depression (51% women versus 32% men). A majority were exposed to psychosocial stressors. Women had more PDFs, in median 5 [inter-quartile ranges (IQR) 4–8] versus men 3 (IQR 2–5), and also more pain sites, in median 3 (IQR 2–5) versus men in median 2 (IQR 1–3). For men, the regression calculations revealed that numbers of PDFs associated only with increasing numbers of pain sites (B 0.871P< 0.001). For women, this association was weaker (B 0.364,P< 0.001), with significant values also for age (B 0.103) and sick leave > one year (B 0.767,P= 0.010), and a negative predicting value for interpreter support (B −1.198,P< 0.043). To conclude, PDFs associated often with somatic findings but varied much among the women. This implies potential problems regarding cause, function and sick leave questions. However, support by professional interpreters may facilitate a shared understanding with immigrant women having long-standing pain.
Inter-professional education and primary care: EFPC position paper
Authors: Miller Robin , Scherpbier Nynke , van Amsterdam Loes , Guedes Virgínia , Pype Peter 
Published: October 2019

Abstract
Inter-professional education (IPE) can support professionals in developing their ability to work collaboratively. This position paper from the European Forum for Primary Care considers the design and implementation of IPE within primary care. This paper is based on workshops and is an evidence review of good practice. Enablers of IPE programmes are involving patients in the design and delivery, providing a holistic focus, focussing on practical actions, deploying multi-modal learning formats and activities, including more than two professions, evaluating formative and summative aspects, and encouraging team-based working. Guidance for the successful implementation of IPE is set out with examples from qualifying and continuing professional development programmes.
Loneliness among cancer caregivers: A narrative review
Authors: Gray Tamryn F. , Azizoddin Desiree R. , Nersesian Paula V. 
Published: October 2019

AbstractObjectiveProviding care to a loved one with cancer places demands on caregivers that result in changes to their daily routines and disruptions to their social relationships that then contribute to loneliness. Though caregivers’ psychosocial challenges have been well studied, loneliness — a determinant of health — has not been well studied in this population. This narrative review sought to describe the current evidence on loneliness among caregivers of cancer patients. We aimed to (1) define loneliness, (2) describe its prevalence, (3) describe the association between loneliness and health outcomes, (4) describe risks and consequences of loneliness among cancer caregivers, (5) identify ways to assess loneliness, and (6) recommend strategies to mitigate loneliness in this unique population.MethodWe used evidence from articles listed in PubMed, PsycINFO, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases, book chapters, and reports. Articles were reviewed for the following inclusion criteria: (1) published in English, (2) caregivers of cancer patients, (3) loneliness as a study variable, and (4) peer-reviewed with no restriction on the timeframe of publication. Caregivers were defined as relatives, friends, or partners who provide most of the care and support for someone with cancer.ResultsEighteen studies met inclusion criteria and were included in the analysis. Caregivers’ experiences of loneliness can contribute to negative effects on one's social, emotional, and physical well-being. Social support interventions may not be sufficient to address this problem. Existing recommendations to mitigate loneliness include cognitive and psychological reframing, one-on-one and group therapy, befriending, resilience training, and technology-based interventions.Significance of resultsLimited attention to loneliness in cancer caregivers poses a twofold problem that impacts patient and caregiver outcomes. Interventions are critically needed to address loneliness as a determinant of health in caregivers, given their pivotal role in providing care and impacting health outcomes for people with cancer.
Quality improvement in hospitals in the Russian Federation, 2000–2016: a systematic review
Authors: Vlassov Vasiliy V. , Bates Katie , McKee Martin 
Published: October 2019

AbstractWe reviewed published evidence on quality improvement in hospitals in the Russian Federation since 2000. We used three data sources: MEDLINE, ‘Rossiiskaia Meditsina’ (Central Scientific Medical Library), and elibrary.ru using specific search terms. No language or study design restrictions were imposed. In total, 1717 articles were identified; 51 met the inclusion criteria and were thematically analysed. Russian legislation, government acts and grey literature were sourced to contextualise identified themes. Since 2010, the Federal Ministry of Health has increasingly sought to improve quality of care, providing additional resources and new initiatives across the health system. These include clinical practice guidelines, pay for performance schemes, electronic medical records, more specialist care, paraclinical care, and quality control systems. Quality of care, increasingly a concern of the Russian government, is said to be improving. Yet most initiatives have rarely been evaluated. This reflects the limited capacity for health services research in Russia. It seems likely that the full potential for improvements in quality of care in Russia is still to be realised.
CtBP—a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma
Authors: Chawla Ayesha T. , Chougoni Kranthi Kumar , Joshi Prashant J. , Cororaton Agnes D. , Memari Patrick , Stansfield John C. , Park Haemin , Seth Rashmi , Szomju Barbara , Sima Adam P. , Idowu Michael O. , Ellis Keith C. , Grossman Steven R. 
Published: October 2019

AbstractCtbp2 is a uniquely targetable oncogenic transcriptional coregulator, exhibiting overexpression in most common solid tumors, and critical to the tumor-initiating cell (TIC) transcriptional program. In the “CKP” mouse pancreatic ductal adenocarcinoma (PDAC) model driven by mutant K-Ras, Ctbp2 haploinsufficiency prolonged survival, abrogated peritoneal metastasis, and caused dramatic downregulation of c-Myc, a known critical dependency for TIC activity and tumor progression in PDAC. A small-molecule inhibitor of CtBP2, 4-chloro-hydroxyimino phenylpyruvate (4-Cl-HIPP) phenocopied Ctbp2 deletion, decreasing tumor burden similarly to gemcitabine, and the combination of 4-Cl-HIPP and gemcitabine further synergistically suppressed tumor growth. Pharmacodynamic monitoring revealed that the 4-Cl-HIPP/gemcitabine combination induced robust and synergistic tumor apoptosis and marked downregulation of the TIC marker CD133 in CKP PDAC tumors. Collectively, our data demonstrate that targeting CtBP represents a fruitful avenue for development of highly active agents in PDAC that cooperate with standard therapy to limit both primary and metastatic tumor burden.
Engaging with research impact assessment for an environmental science case study
Authors: Fryirs Kirstie A. , Brierley Gary J. , Dixon Thom 
Published: October 2019

AbstractImpact assessment is embedded in many national and international research rating systems. Most applications use the Research Impact Pathway to track inputs, activities, outputs and outcomes of an invention or initiative to assess impact beyond scholarly contributions to an academic research field (i.e., benefits to environment, society, economy and culture). Existing approaches emphasise easy to attribute ‘hard’ impacts, and fail to include a range of ‘soft’ impacts that are less easy to attribute, yet are often a dominant part of the impact mix. Here, we develop an inclusive 3-part impact mapping approach. We demonstrate its application using an environmental initiative.
In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
Authors: Amoasii Leonela , Li Hui , Zhang Yu , Min Yi-Li , Sanchez-Ortiz Efrain , Shelton John M. , Long Chengzu , Mireault Alex A. , Bhattacharyya Samadrita , McAnally John R. , Bassel-Duby Rhonda , Olson Eric N. 
Published: October 2019

AbstractDuchenne muscular dystrophy (DMD) is a fatal genetic disorder caused by mutations in the dystrophin gene. To enable the non-invasive analysis of DMD gene correction strategies in vivo, we introduced a luciferase reporter in-frame with the C-terminus of the dystrophin gene in mice. Expression of this reporter mimics endogenous dystrophin expression and DMD mutations that disrupt the dystrophin open reading frame extinguish luciferase expression. We evaluated the correction of the dystrophin reading frame coupled to luciferase in mice lacking exon 50, a common mutational hotspot, after delivery of CRISPR/Cas9 gene editing machinery with adeno-associated virus. Bioluminescence monitoring revealed efficient and rapid restoration of dystrophin protein expression in affected skeletal muscles and the heart. Our results provide a sensitive non-invasive means of monitoring dystrophin correction in mouse models of DMD and offer a platform for testing different strategies for amelioration of DMD pathogenesis.
Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy
Authors: Damman Reinier , Schütz Stefan , Luo Yanzhang , Weingarth Markus , Sprangers Remco , Baldus Marc 
Published: October 2019

AbstractLiquid–liquid phase separation is increasingly recognized as a process involved in cellular organization. Thus far, a detailed structural characterization of this intrinsically heterogeneous process has been challenging. Here we combine solid- and solution-state NMR spectroscopy to obtain atomic-level insights into the assembly and maturation of cytoplasmic processing bodies that contain mRNA as well as enzymes involved in mRNA degradation. In detail, we have studied the enhancer of decapping 3 (Edc3) protein that is a central hub for processing body formation in yeast. Our results reveal that Edc3 domains exhibit diverse levels of structural organization and dynamics after liquid–liquid phase separation. In addition, we find that interactions between the different Edc3 domains and between Edc3 and RNA in solution are largely preserved in the condensed protein state, allowing processing bodies to rapidly form and dissociate upon small alterations in the cellular environment.
3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors
Authors: Sood Disha , Tang-Schomer Min , Pouli Dimitra , Mizzoni Craig , Raia Nicole , Tai Albert , Arkun Knarik , Wu Julian , Black Lauren D. , Scheffler Bjorn , Georgakoudi Irene , Steindler Dennis A. , Kaplan David L. 
Published: October 2019

AbstractDynamic alterations in the unique brain extracellular matrix (ECM) are involved in malignant brain tumors. Yet studies of brain ECM roles in tumor cell behavior have been difficult due to lack of access to the human brain. We present a tunable 3D bioengineered brain tissue platform by integrating microenvironmental cues of native brain-derived ECMs and live imaging to systematically evaluate patient-derived brain tumor responses. Using pediatric ependymoma and adult glioblastoma as examples, the 3D brain ECM-containing microenvironment with a balance of cell-cell and cell-matrix interactions supports distinctive phenotypes associated with tumor type-specific and ECM-dependent patterns in the tumor cells’ transcriptomic and release profiles. Label-free metabolic imaging of the composite model structure identifies metabolically distinct sub-populations within a tumor type and captures extracellular lipid-containing droplets with potential implications in drug response. The versatile bioengineered 3D tumor tissue system sets the stage for mechanistic studies deciphering microenvironmental role in brain tumor progression.
Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity
Authors: Kim Gijeong , Azmi Liyana , Jang Seongmin , Jung Taeyang , Hebert Hans , Roe Andrew J. , Byron Olwyn , Song Ji-Joon 
Published: October 2019

AbstractAldehyde-alcohol dehydrogenase (AdhE) is a key enzyme in bacterial fermentation, converting acetyl-CoA to ethanol, via two consecutive catalytic reactions. Here, we present a 3.5 Å resolution cryo-EM structure of full-length AdhE revealing a high-order spirosome architecture. The structure shows that the aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) active sites reside at the outer surface and the inner surface of the spirosome respectively, thus topologically separating these two activities. Furthermore, mutations disrupting the helical structure abrogate enzymatic activity, implying that formation of the spirosome structure is critical for AdhE activity. In addition, we show that this spirosome structure undergoes conformational change in the presence of cofactors. This work presents the atomic resolution structure of AdhE and suggests that the high-order helical structure regulates its enzymatic activity.