bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy Transfer Induced by Dye Encapsulation in a Hybrid Nanoparticle‐Purple Membrane Reversible Assembly
Authors: de Q. Silveira Gleiciani , Chen Zhaowei , Barry Edward F. , Diroll Benjamin T. , Lee Byeongdu , Rajh Tijana , Rozhkova Elena A. , Laible Philip D. , Fry H. Christopher 
Published: August 2019

AbstractThe purple membrane (PM) isolated from the bacteria Halobacterium salinarum (H. salinarum) arranges the transmembrane proton pump bacteriorhodopsin (bR) in a 2D hexagonal crystalline lattice. Here, PM sheets containing native bR bend into tube‐like structures with open edges under acidic pH conditions. When decorated with gold nanoparticles (AuNPs), these same PM sheets yield a sealed tube assembly. Upon Rhodamine B (Rh B) sequestration inside the sealed tube, a dramatic decrease in Rh B fluorescence lifetime (τf) from 1.5 ns (unencapsulated) to 14 ps (encapsulated) is observed. The dramatic decrease in lifetime is attributed to energy transfer between AuNPs and Rh B. Subsequent release from the AuNP–PM capsules triggered by an increase in pH shows that 93% of Rh B is recovered (τ = 14 min) due to the capsules' unfolding. The hybrid AuNP–PM material highlights the utility of multicomponent ensembles (i.e., lipid bilayer, protein array, and NPs) by demonstrating that complex, multistimuli 3D responses can lead to multiplexed functions such as controlling energy transfer in the confined, encapsulated state and breaking the energy pair via molecular release in response to a change in pH.
Heterotypic Scaffold Design Orchestrates Primary Cell Organization and Phenotypes in Cocultured Small Diameter Vascular Grafts
Authors: Jungst Tomasz , Pennings Iris , Schmitz Michael , Rosenberg Antoine J. W. P. , Groll Jürgen , Gawlitta Debby 
Published: August 2019

AbstractTo facilitate true regeneration, a vascular graft should direct the evolution of a neovessel to obtain the function of a native vessel. For this, scaffolds have to permit the formation of an intraluminal endothelial cell monolayer, mimicking the tunica intima. In addition, when attempting to mimic a tunica media‐like outer layer, the stacking and orientation of vascular smooth muscle cells (vSMCs) should be recapitulated. An integral scaffold design that facilitates this has so far remained a challenge. A hybrid fabrication approach is introduced by combining solution electrospinning and melt electrowriting. This allows a tissue‐structure mimetic, hierarchically bilayered tubular scaffold, comprising an inner layer of randomly oriented dense fiber mesh and an outer layer of microfibers with controlled orientation. The scaffold supports the organization of a continuous luminal endothelial monolayer and oriented layers of vSM‐like cells in the media, thus facilitating control over specific and tissue‐mimetic cellular differentiation and support of the phenotypic morphology in the respective layers. Neither soluble factors nor a surface bioactivation of the scaffold is needed with this approach, demonstrating that heterotypic scaffold design can direct physiological tissue‐like cell organization and differentiation.
Microstructural and Interfacial Designs of Oxygen‐Permeable Membranes for Oxygen Separation and Reaction–Separation Coupling
Authors: Zhu Xuefeng , Yang Weishen 
Published: August 2019

AbstractMixed ionic–electronic conducting oxygen‐permeable membranes can rapidly separate oxygen from air with 100% selectivity and low energy consumption. Combining reaction and separation in an oxygen‐permeable membrane reactor significantly simplifies the technological scheme and reduces the process energy consumption. Recently, materials design and mechanism investigations have provided insight into the microstructural and interfacial effects. The microstructures of the membrane surfaces and bulk are closely related to the interfacial oxygen exchange kinetics and bulk diffusion kinetics. Therefore, the permeability and stability of oxygen‐permeable membranes with a single‐phase structure and a dual‐phase structure can be adjusted through their microstructural and interfacial designs. Here, recent advances in the development of oxygen permeation models that provide a deep understanding of the microstructural and interfacial effects, and strategies to simultaneously improve the permeability and stability through microstructural and interfacial design are discussed in detail. Then, based on the developed high‐performance membranes, highly effective membrane reactors for process intensification and new technology developments are highlighted. The new membrane reactors will trigger innovations in natural gas conversion, ammonia synthesis, and hydrogen‐related clean energy technologies. Future opportunities and challenges in the development of oxygen‐permeable membranes for oxygen separation and reaction–separation coupling are also explored.
Ceria Nanoparticles Meet Hepatic Ischemia‐Reperfusion Injury: The Perfect Imperfection
Authors: Ni Dalong , Wei Hao , Chen Weiyu , Bao Qunqun , Rosenkrans Zachary T. , Barnhart Todd E. , Ferreira Carolina A. , Wang Yanpu , Yao Heliang , Sun Tuanwei , Jiang Dawei , Li Shiyong , Cao Tianye , Liu Zhaofei , Engle Jonathan W. , Hu Ping , Lan Xiaoli , Cai Weibo 
Published: August 2019

AbstractThe mononuclear phagocyte system (MPS, e.g., liver, spleen) is often treated as a “blackbox” by nanoresearchers in translating nanomedicines. Often, most of the injected nanomaterials are sequestered by the MPS, preventing their delivery to the desired disease areas. Here, this imperfection is exploited by applying nano‐antioxidants with preferential liver uptake to directly prevent hepatic ischemia‐reperfusion injury (IRI), which is a reactive oxygen species (ROS)‐related disease. Ceria nanoparticles (NPs) are selected as a representative nano‐antioxidant and the detailed mechanism of preventing IRI is investigated. It is found that ceria NPs effectively alleviate the clinical symptoms of hepatic IRI by scavenging ROS, inhibiting activation of Kupffer cells and monocyte/macrophage cells. The released pro‐inflammatory cytokines are then significantly reduced and the recruitment and infiltration of neutrophils are minimized, which suppress subsequent inflammatory reaction involved in the liver. The protective effect of nano‐antioxidants against hepatic IRI in living animals and the revealed mechanism herein suggests their future use for the treatment of hepatic IRI in the clinic.
Efficient Synthesis of 12‐Oxochenodeoxycholic Acid Using a 12α‐Hydroxysteroid Dehydrogenase from Rhodococcus ruber
Authors: Shi Shou‐Cheng , You Zhi‐Neng , Zhou Ke , Chen Qi , Pan Jiang , Qian Xiao‐Long , Xu Jian‐He , Li Chun‐Xiu 
Published: August 2019

Abstract12α‐Hydroxysteroid dehydrogenase (12α‐HSDH) has the potential to convert cheap and readily available cholic acid (CA) to 12‐oxochenodeoxycholic acid (12‐oxo‐CDCA), a key precursor for chemoenzymatic synthesis of the therapeutic bile acid ursodeoxycholic acid (UDCA). In this work, a native nicotinamide adenine dinucleotide (NAD+)‐dependent 12α‐hydroxysteroid dehydrogenase (Rr12α‐HSDH) from Rhodococcus ruber was identified using a structure‐guided genome mining (SSGM) approach, which is based on the structure of cofactor pocket and the conserved nicotinamide cofactor binding motif alignment. Rr12α‐HSDH was heterologously overexpressed in Escherichia coli BL21 (DE3), purified and characterized. The purified Rr12α‐HSDH showed a high oxidative activity of 290 U mg−1protein toward CA, with a catalytic efficiency (kcat/KM) of 5.10×103 mM−1 s−1. In a preparative biotransformation (100 mL), CA (200 mM, 80 g L−1) was efficiently converted to 12‐oxo‐CDCA in 1 h, with a 85% isolated yield and a space‐time yield (STY) of up to 1632 g L−1 d−1. Furthermore, Rr12α‐HSDH was shown to be able to catalyze the oxidation of other 12α‐hydroxysteroids at high substrate loads (up to 200 mM), giving the corresponding 12‐oxo‐hydroxysteroids in 71%–85% yields, indicating the great potential of Rr12α‐HSDH as a promising biocatalyst for the synthesis of various therapeutic bile acids.magnified image
Spray‐flame synthesis of La(Fe, Co)O3 nano‐perovskites from metal nitrates
Authors: Angel Steven , Neises Julian , Dreyer Maik , Friedel Ortega Klaus , Behrens Malte , Wang Yuan , Arandiyan Hamidreza , Schulz Christof , Wiggers Hartmut 
Published: August 2019

AbstractNano‐sized perovskites were synthesized in a spray flame from nitrate precursors dissolved in ethanol and in ethanol/2‐ethylhexanoic acid (2‐EHA) mixtures. Experiments with ethanol led to a broad particle‐size distribution and to the formation of undesired phases such as La2CoO4, La2O3, and Co3O4. The addition of 2‐EHA can initiate micro explosions of the burning droplets and has been systematically investigated toward the formation of single‐phase, high‐surface‐area LaCoO3 and LaFeO3 with a narrow size distribution. To investigate the effect of 2‐EHA, temperature‐dependent changes of the chemical composition of the precursor solutions were analyzed with ATR‐FTIR between 23 and 70°C. In all cases, the formation of esters was identified while in the solutions containing iron, additional formation of carboxylates was observed. The synthesized materials were characterized by BET SSA, XRD, SAED and EDX‐TEM and their catalytic activity was analyzed, reaching 50% CO conversion at temperatures below 160 and 300°C for LaCoO3 and LaFeO3, respectively.
Recognition and management of adults with Turner syndrome: From the transition of adolescence through the senior years
Authors: Lin Angela E. , Prakash Siddharth K. , Andersen Niels H. , Viuff Mette H. , Levitsky Lynne L. , Rivera‐Davila Michelle , Crenshaw Melissa L. , Hansen Lars , Colvin Mary K. , Hayes Frances J. , Lilly Evelyn , Snyder Emma A. , Nader‐Eftekhari Shahla , Aldrich Melissa B. , Bhatt Ami B. , Prager Laura M. , Arenivas Ana , Skakkebaek Anne , Steeves Marcie A. , Kreher Jeffrey B. , Gravholt Claus H. 
Published: August 2019

AbstractTurner syndrome is recognized now as a syndrome familiar not only to pediatricians and pediatric specialists, medical geneticists, adult endocrinologists, and cardiologists, but also increasingly to primary care providers, internal medicine specialists, obstetricians, and reproductive medicine specialists. In addition, the care of women with Turner syndrome may involve social services, and various educational and neuropsychologic therapies. This article focuses on the recognition and management of Turner syndrome from adolescents in transition, through adulthood, and into another transition as older women. It can be viewed as an interpretation of recent international guidelines, complementary to those recommendations, and in some instances, an update. An attempt was made to provide an international perspective. Finally, the women and families who live with Turner syndrome and who inspired several sections, are themselves part of the broad readership that may benefit from this review.
Tight Xenon Confinement in a Crystalline Sandwich‐like Hydrogen‐Bonded Dimeric Capsule of a Cyclic Peptide
Authors: Pizzi Andrea , Ozores Haxel Lionel , Calvelo Martín , García‐Fandiño Rebeca , Amorín Manuel , Demitri Nicola , Terraneo Giancarlo , Bracco Silvia , Comotti Angiolina , Sozzani Piero , Bezuidenhout Charl X. , Metrangolo Pierangelo , Granja Juan R. 
Published: August 2019

AbstractA cyclic hexapeptide with three pyridyl moieties connected to its backbone forms a hydrogen‐bonded dimer, which tightly encapsulates a single xenon atom, like a pearl in its shell. The dimer imprints its shape and symmetry to the captured xenon atom, as demonstrated by 129Xe NMR spectroscopy, single‐crystal X‐ray diffraction, and computational studies. The dimers self‐assemble hierarchically into tubular structures to form a porous supramolecular architecture, whose cavities are filled by small molecules and gases.
Self‐Stabilized Amorphous Organic Materials with Room‐Temperature Phosphorescence
Authors: Xu Wei , Yu Yaguo , Ji Xiaonan , Zhao Huarui , Chen Jinming , Fu Yanyan , Cao Huimin , He Qingguo , Cheng Jiangong 
Published: August 2019

AbstractThe stability of pure organic room‐temperature phosphorescent (RTP) materials in air has been a research hotspot in recent years. Without crystallization or encapsulation, a new strategy was proposed to obtain self‐stabilized organic RTP materials, based on a complete ionization of a photo‐induced charge separation system. The ionization of aromatic phenol 4‐carbazolyl salicylaldehyde (CSA) formed a stable H‐bonding anion–cation radical structure and led to the completely amorphous CSA‐I film. Phosphorescent lifetimes as long as 0.14 s at room temperature and with direct exposure to air were observed. The emission intensity was also increased by 21.5‐fold. Such an amorphous RTP material reconciled the contradiction between phosphorescence stability and vapor permeability and has been successfully utilized for peroxide vapor detection.
Eine ungewöhnliche Gerüstumlagerung in der Biosynthese des Sesquiterpens Trichobrasilenol aus Trichoderma
Authors: Murai Keiichi , Lauterbach Lukas , Teramoto Kazuya , Quan Zhiyang , Barra Lena , Yamamoto Tsuyoshi , Nonaka Kenichi , Shiomi Kazuro , Nishiyama Makoto , Kuzuyama Tomohisa , Dickschat Jeroen S. 
Published: August 2019

AbstractDie Gerüste mancher Klassen von Terpenen sind ungewöhnlich, da sie eine größere Anzahl an Me‐Gruppen (oder biosynthetische Äquivalente wie olefinische Methylengruppen, Hydroxymethylgruppen, Aldehyde oder Carbonsäuren und ihre Derivate) aufweisen als durch ihren Oligoprenyldiphosphatvorläufer zur Verfügung gestellt werden. Dies resultiert manchmal aus einer oxidativen Ringöffnungsreaktion an einem von einer Terpencyclase gebildeten Molekül mit regulärer Anzahl von Me‐Gruppenäquivalenten, wie es für die Picrotoxan‐Sesquiterpene beobachtet wird. In dieser Studie wird eine Sesquiterpencyclase aus Trichoderma beschrieben, die Farnesyldiphosphat (FPP) direkt unter Beteiligung einer bemerkenswerten Gerüstumlagerung in Trichobrasilenol, ein neues Brasilan‐Sesquiterpen mit einem verglichen mit FPP zusätzlichen Me‐Gruppenäquivalent, umsetzen kann. Eine mechanistische Hypothese für die Bildung des Brasilan‐Skeletts wird durch extensive Isotopenmarkierungsstudien gestützt.
Tetravinylallene
Authors: Elgindy Cecile , Ward Jas S. , Sherburn Michael S. 
Published: August 2019

AbstractThe first chemical synthesis of tetravinylallene (3,5‐divinylhepta‐1,3,4,6‐tetraene) is reported. The final, key step of the synthesis involves a palladium‐catalyzed, Negishi‐type cross‐coupling involving 1,5‐transposition of a penta‐2‐en‐4‐yn‐1‐ol methanesulfonate. The unprecedented fundamental hydrocarbon is sufficiently stable to be purified by flash chromatography. A similar synthetic pathway grants access to the first substituted tetravinylallenes, which provide insights into the influence of substitution upon stability and reactivity. Tetravinylallenes are shown to break new ground in swift structural complexity creation, with three novel sequences reported.
Aggregation‐Induced Emission Gold Clustoluminogens for Enhanced Low‐Dose X‐ray‐Induced Photodynamic Therapy
Authors: Sun Wenjing , Luo Li , Feng Yushuo , Cai Yuting , Zhuang Yixi , Xie Rong‐Jun , Chen Xiaoyuan , Chen Hongmin 
Published: August 2019

AbstractThe use of gold nanoparticles as radiosensitizers is an effective way to boost the killing efficacy of radiotherapy while drastically limiting the received dose and reducing the possible damage to normal tissues. Herein, we designed aggregation‐induced emission gold clustoluminogens (AIE‐Au) to achieve efficient low‐dose X‐ray‐induced photodynamic therapy (X‐PDT) with negligible side effects. The aggregates of glutathione‐protected gold clusters (GCs) assembled through a cationic polymer enhanced the X‐ray‐excited luminescence by 5.2‐fold. Under low‐dose X‐ray irradiation, AIE‐Au strongly absorbed X‐rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, X‐ray‐induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect. The in vitro and in vivo experiments demonstrated that AIE‐Au effectively triggered the generation of reactive oxygen species with an order‐of‐magnitude reduction in the X‐ray dose, enabling highly effective cancer treatment.
Dianionic Mononuclear Cyclo‐P4 Complexes of Zero‐Valent Molybdenum: Coordination of the Cyclo‐P4 Dianion in the Absence of Intramolecular Charge Transfer
Authors: Mandla Kyle A. , Neville Michael L. , Moore Curtis E. , Rheingold Arnold L. , Figueroa Joshua S. 
Published: August 2019

AbstractRelative to other cyclic poly‐phosphorus species (that is, cyclo‐Pn), the planar cyclo‐P4 group is unique in its requirement of two additional electrons to achieve aromaticity. These electrons are supplied from one or more metal centers. However, the degree of charge transfer is dependent on the nature of the metal fragment. Unique examples of dianionic mononuclear η4‐P4 complexes are presented that can be viewed as the simple coordination of the [cyclo‐P4]2− dianion to a neutral metal fragment. Treatment of the neutral, molybdenum cyclo‐P4 complexes Mo(η4‐P4)I2(CO)(CNArDipp2)2 and Mo(η4‐P4)(CO)2(CNArDipp2)2 with KC8 produces the dianionic, three‐legged piano stool complexes, [Mo(η4‐P4)(CO)(CNArDipp2)2]2− and [Mo(η4‐P4)(CO)2(CNArDipp2)]2−, respectively. Structural, spectroscopic, and computational studies reveal a similarity to the classic η6‐benzene complex (η6‐C6H6)Mo(CO)3 regarding the metal‐center valence state and electronic population of the planar‐cyclic ligand π system.
Observing the Reversible Single Molecule Electrochemistry of Alexa Fluor 647 Dyes by Total Internal Reflection Fluorescence Microscopy
Authors: Fan Sanjun , Webb James E. A. , Yang Ying , Nieves Daniel J. , Gonçales Vinicius R. , Tran Jason , Hilzenrat Geva , Kahram Mohaddeseh , Tilley Richard D. , Gaus Katharina , Gooding J. Justin 
Published: August 2019

AbstractAlexa Fluor 647 is a widely used fluorescent probe for cell bioimaging and super‐resolution microscopy. Herein, the reversible fluorescence switching of Alexa Fluor 647 conjugated to bovine serum albumin (BSA) and adsorbed onto indium tin oxide (ITO) electrodes under electrochemical potential control at the level of single protein molecules is reported. The modulation of the fluorescence as a function of potential was observed using total internal reflectance fluorescence (TIRF) microscopy. The fluorescence intensity of the Alexa Fluor 647 decreased, or reached background levels, at reducing potentials but returned to normal levels at oxidizing potentials. These electrochemically induced changes in fluorescence were sensitive to pH despite that BSA‐Alexa Fluor 647 fluorescence without applied potential is insensitive to pH between values of 4–10. The observed pH dependence indicated the involvement of electron and proton transfer in the fluorescence switching mechanism.
Copper‐Rich Thermoelectric Sulfides: Size‐Mismatch Effect and Chemical Disorder in the [TS4]Cu6 Complexes of Cu26T2Ge6S32 (T=Cr, Mo, W) Colusites
Authors: Pavan Kumar Ventrapati , Guélou Gabin , Lemoine Pierric , Raveau Bernard , Supka Andrew R. , Al Rahal Al Orabi Rabih , Fornari Marco , Suekuni Koichiro , Guilmeau Emmanuel 
Published: August 2019

AbstractHerein, we investigate the Mo and W substitution for Cr in synthetic colusite, Cu26Cr2Ge6S32. Primarily, we elucidate the origin of extremely low electrical resistivity which does not compromise the Seebeck coefficient and leads to outstanding power factors of 1.94 mW m−1 K−2 at 700 K in Cu26Cr2Ge6S32. We demonstrate that the abnormally long iono‐covalent T–S bonds competing with short metallic Cu–T interactions govern the electronic transport properties of the conductive “Cu26S32” framework. We address the key role of the cationic size‐mismatch at the core of the mixed tetrahedral–octahedral complex over the transport properties. Two essential effects are identified: 1) only the tetrahedra that are directly bonded to the [TS4]Cu6 complex are significantly distorted upon substitution and 2) the major contribution to the disorder is localized at the central position of the mixed tetrahedral–octahedral complex, and is maximized for x=1, i.e. for the highest cationic size‐variance, σ2.
Scaled‐Up Synthesis of Amorphous NiFeMo Oxides and Their Rapid Surface Reconstruction for Superior Oxygen Evolution Catalysis
Authors: Duan Yu , Yu Zi‐You , Hu Shao‐Jin , Zheng Xu‐Sheng , Zhang Chu‐Tian , Ding Hong‐He , Hu Bi‐Cheng , Fu Qi‐Qi , Yu Zhi‐Long , Zheng Xiao , Zhu Jun‐Fa , Gao Min‐Rui , Yu Shu‐Hong 
Published: August 2019

AbstractThe anode oxygen evolution reaction (OER) is known to largely limit the efficiency of electrolyzers owing to its sluggish kinetics. While crystalline metal oxides are promising as OER catalysts, their amorphous phases also show high activities. Efforts to produce amorphous metal oxides have progressed slowly, and how an amorphous structure benefits the catalytic performances remains elusive. Now the first scalable synthesis of amorphous NiFeMo oxide (up to 515 g in one batch) is presented with homogeneous elemental distribution via a facile supersaturated co‐precipitation method. In contrast to its crystalline counterpart, amorphous NiFeMo oxide undergoes a faster surface self‐reconstruction process during OER, forming a metal oxy(hydroxide) active layer with rich oxygen vacancies, leading to superior OER activity (280 mV overpotential at 10 mA cm−2 in 0.1 m KOH). This opens up the potential of fast, facile, and scale‐up production of amorphous metal oxides for high‐performance OER catalysts.
DGEBA‐polyaminoamide as effective anti‐corrosive material for 15CDV6 steel in NaCl medium: Computational and experimental studies
Authors: Dagdag Omar , Berisha Avni , Safi Zaki , Hamed Othman , Jodeh Shehdeh , Verma Chandrabhan , Ebenso E. E. , El Harfi Ahmed 
Published: August 2019

ABSTRACTThe present study is focusing on evaluating theoretically and experimentally stability and type of interactions between the epoxy resin bisphenol A diglycidyl ether (DGEBA)‐polyaminoamide anticorrosive coating and high strength low alloy steel surface 15CDV6. The coated steel samples were subjected to a harsh environment of an electrolyte solution of 3 wt % NaCl to simulate the corrosive marine environment. The performance of the epoxy coating was investigated using electrochemical impedance spectroscopy (EIS). The EIS results revealed the occurrence of some deterioration in the film after subjecting it to a harsh environment for 4392 h, because the impedance of the coating dropped by about 1.4 kΩ.cm2. Surface morphological study of metallic specimens before and after exposing to the simulated marine environment (3 wt % NaCl) was carried out using scanning electron microscopy, energy dispersive spectroscopy (EDS), and optical microscope (OM) methods. The interactions between DGEBA‐polyaminoamide and the metallic surface were further carried out using computation modeling such as density functional theory (DFT)‐based quantum chemical calculations, Monte Carlo (MC), and molecular dynamics (MD) simulations. Results showed that DGEBA‐polyaminoamide possesses a strong tendency to adhere and inhibits the corrosive dissolution of 15CDV6 steel surface in the stimulated marine environment. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48402.