bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transport corridors and their wider economic benefits: A quantitative review of the literature
Authors: Roberts Mark , Melecky Martin , Bougna Théophile , Xu Yan (Sarah) 
Published: September 2019

AbstractTransport corridors can generate both wider economic benefits (WEBs) and costs through their effects on diverse development outcomes. To advance understanding of how corridors could generate WEBs, this paper undertakes a quantitative review and meta‐analysis of the literature that estimates the impacts of large transport infrastructure projects. The analysis finds that characteristics of individual studies and the design of the transport infrastructure influence estimated benefits. It also shows that, on average, while corridor interventions tend to benefit economic welfare and equity, they often detrimentally impact the environment. To mitigate trade‐offs, policymakers can consider using complementary interventions.
I Don't See Race (or Conflict): Strategic Descriptions of Ambiguous Negative Intergroup Contexts
Authors: Karmali Francine , Kawakami Kerry , Vaccarino Elysia , Williams Amanda , Phills Curtis , Friesen Justin P. 
Published: September 2019

AbstractDespite current societal trends to encourage diversity, individuals often avoid acknowledging race, and we suggest also conflict, because of concerns about appearing prejudiced. The present research investigated the use of racial color and conflict blind strategies in an ambiguous negative intergroup context. In three studies, we assessed whether people acknowledged race and conflict using a novel ambiguous context task. Study 1 demonstrated that when describing an intergroup interaction with a photograph of Black and White males bumping into one another, only 27% of participants used racial labels and approximately half (53%) mentioned conflict. In Study 2, when participants described two White males in the same situation, significantly fewer participants mentioned conflict compared to when the photograph depicted a Black and White male actor, but rates of mentioning race were not different. Finally, in Study 3, when participants were instructed to use race when describing the actors, they mentioned conflict significantly less than when they were free to avoid racial labels. These latter results suggest that although racial color blindness may be used to appear unbiased, when this strategy is unavailable, people may resort to not referencing intergroup negativity. Together these findings indicate that racial color and conflict blindness may work in conjunction as compensatory strategies to appearing nonprejudiced.
The effect of the source and dosage of dietary Cu on redox status in rat tissues
Authors: Ognik Katarzyna , Cholewińska Ewelina , Tutaj Krzysztof , Cendrowska‐Pinkosz Monika , Dworzański Wojciech , Dworzańska Anna , Juśkiewicz Jerzy 
Published: September 2019

AbstractThe aim of this experiment was to investigate whether the amount of Cu added to the diet of rats can be reduced without adversely affecting the antioxidant status of tissues and growth, and whether copper nanoparticles can be used for this purpose. For four weeks, four experimental groups of rats were fed diets with two dosages of added Cu (standard—6.5 or 3.25 mg/kg) in two forms (standard—CuCO3 or copper nanoparticles). Replacing the CuCO3 supplement with CuNPs resulted in a decreased lung weight and an increased Cu content in brain, kidney and lung, intensification of lipid peroxidation processes, and weakened antioxidant defence in the lungs and kidneys. This treatment also reduced the Cu content in heart, level of lipid oxidation in the liver and testes and improved antioxidant defence in the brain. Reducing the addition of Cu to the diet from 6.5 to 3.25 mg/kg reduced lung weight and increased lipid peroxidation in the liver, heart and lungs, and also weakened antioxidant defence in the lungs and testes. This treatment also weakened the lipid peroxidation process in the spleen, small intestine and brain and strengthened the antioxidant defence of the brain and kidneys. In conclusion, replacing CuCO3 with CuNPs and reducing the level of Cu in the diet of rats has a particularly unfavourable effect on the respiratory system, causing adverse changes in the lungs. However, these treatments have a clearly positive effect on the redox status of the liver and brain.
TAZ contributes to osteogenic differentiation of periodontal ligament cells under tensile stress
Authors: Wang Yi , Hu Bibo , Hu Rongdang , Tong Xianqin , Zhang Menghan , Xu Chuchu , He Zhiqi , Zhao Ya , Deng Hui 
Published: September 2019

AbstractBackground and objectiveBone remodeling during orthodontic treatment is achieved by the osteogenesis of human periodontal ligament cells (PDLCs) subjected to mechanical loadings. Transcriptional co‐activator with PDZ‐binding motif (TAZ) mediates bone remodeling in response to extracellular mechanical signals. This study aims to investigate the role of TAZ in osteogenesis of PDLCs under tensile strain.Materials and methodsA uniaxial cyclic tensile stress (CTS) at 12% elongation and 6 cycles/min (5 s on and 5 s off) was applied to PDLCs. The osteogenic differentiation was determined by the protein and gene expressions of osteogenic markers using qRT‐PCR and Western blot, respectively, and further by alkaline phosphatase (ALP) activity and Alizarin Red S staining. The interaction of TAZ with core‐binding factor α1 (Cbfα1) was examined by co‐immunoprecipitation. The immunofluorescence histochemistry was used to examine the nucleus aggregation of TAZ and the reorganization of actin filaments. Moreover, small interfering RNA‐targeting TAZ (TAZsiRNA) was used for TAZ inhibition and Y‐27632 was employed for Ras homologue‐associated coiled‐coil protein kinase (ROCK) signaling blockage.ResultsCTS clearly stimulated the nucleus accumulation of TAZ and its interaction with Cbfα1. CTS‐induced osteogenesis in PDLCs was significantly abrogated by the infection with TAZsiRNA, as shown by the decreased stained nodules and protein expressions of Cbfα1, collagen type I, osterix, and osteocalcin, along with the inhibition of β‐catenin signaling. Moreover, ROCK inhibition by Y‐27632 hindered TAZ nucleus aggregation and its binding with Cbfα1, which subsequently lead to the decreased osteoblastic differentiation of PDLCs.ConclusionsTaken together, we propose that TAZ nucleus localization and its interaction with Cbfα1 are essential for the CTS‐induced osteogenic differentiation in PDLCs. And such TAZ activation by CTS could be mediated by ROCK signaling, indicating the pivot role of ROCK‐TAZ pathway for PDLCs differentiation.
Fast Parameter Inference in a Biomechanical Model of the Left Ventricle by Using Statistical Emulation
Authors: Davies Vinny , Noè Umberto , Lazarus Alan , Gao Hao , MacDonald Benn , Berry Colin , Luo Xiaoyu , Husmeier Dirk 
Published: September 2019

SummaryA central problem in biomechanical studies of personalized human left ventricular modelling is estimating the material properties and biophysical parameters from in vivo clinical measurements in a timeframe that is suitable for use within a clinic. Understanding these properties can provide insight into heart function or dysfunction and help to inform personalized medicine. However, finding a solution to the differential equations which mathematically describe the kinematics and dynamics of the myocardium through numerical integration can be computationally expensive. To circumvent this issue, we use the concept of emulation to infer the myocardial properties of a healthy volunteer in a viable clinical timeframe by using in vivo magnetic resonance image data. Emulation methods avoid computationally expensive simulations from the left ventricular model by replacing the biomechanical model, which is defined in terms of explicit partial differential equations, with a surrogate model inferred from simulations generated before the arrival of a patient, vastly improving computational efficiency at the clinic. We compare and contrast two emulation strategies: emulation of the computational model outputs and emulation of the loss between the observed patient data and the computational model outputs. These strategies are tested with two interpolation methods, as well as two loss functions. The best combination of methods is found by comparing the accuracy of parameter inference on simulated data for each combination. This combination, using the output emulation method, with local Gaussian process interpolation and the Euclidean loss function, provides accurate parameter inference in both simulated and clinical data, with a reduction in the computational cost of about three orders of magnitude compared with numerical integration of the differential equations by using finite element discretization techniques.
Grey eosinophils in a Miniature Schnauzer with a poorly differentiated mast cell tumor
Authors: Irvine Katherine L. , Raskin Rose E. , Smith Lauren C. , Friedrichs Kristen R. 
Published: September 2019

AbstractA 10‐year‐old female spayed Miniature Schnauzer was presented for investigation of an intra‐nasal mass. The mass was diagnosed by histopathologic examination as an undifferentiated round cell neoplasm with an infiltrate of segmented leukocytes, interpreted as neutrophilic inflammation. The mass was treated with palliative radiation and systemic chemotherapy due to the presence of regional lymph node metastasis. During subsequent monitoring over several months, the peripheral leukocyte concentration was repeatedly within reference intervals to slightly increased with low numbers of toxic neutrophils. Four months after the initial diagnosis, there was a significant leukocytosis of 66 100 cells/μL, and 39 700 cells/μL of the leukocytes had variably mature, lobulated, and hypolobulated nuclei, and grey cytoplasm with clear vacuoles, resembling grey eosinophils. To further characterize these cells, peripheral blood smears from the patient and a canine control with eosinophilia were stained for alkaline phosphatase (AP), peroxidase, and esterase activities, and with Luxol fast blue (LFB). Histopathologic sections of the nasal mass were stained with LFB and immunohistochemically for tryptase. On blood smears, the cytoplasm of the suspected grey eosinophils stained for AP and granules stained with LFB confirmed that there was an eosinophilic lineage. Peroxidase staining was weak, and esterase staining was absent. On histopathologic sections from the nasal mass, the segmented leukocytes contained LFB‐staining granules, indicating an eosinophilic infiltrate was present. Neoplastic cells expressed tryptase, which confirms a mast cell lineage. Our findings suggest that grey eosinophils might be under‐recognized and interpreted incorrectly as toxic neutrophils. This report expands the canine breeds in which these eosinophils have been identified.
Experimental Analysis of a Micro Gas Turbine Combustor Optimized For Flexible Operation With Various Gaseous Fuel Compositions
Authors: Bower Hannah E. , Schwärzle Andreas , Grimm Felix , Zornek Timo , Kutne Peter 
Published: September 2019

Abstract
With the push to curb dangerous atmospheric pollutant production, energy generation technologies that reduce green-house gas emissions, while still providing adequate electrical supply, are of high importance. With major energy infrastructure already in place, developing enhanced pollutant-reducing combustor systems for micro gas turbines (MGTs), that can utilize low calorific fuels from renewable resources, is a major goal. The current work focuses on the experimental testing of an optimized two-stage combustor designed to operate with various fuel types, including natural gas and syngas produced via biomass gasification. Atmospheric experimental tests were performed and the results indicate larger flame lift-off heights and slightly higher CO gas emissions levels, while displaying lower NOx gas emissions levels for all thermal loads and air-to-fuel equivalence ratios tested, compared to that of the previous combustor designs. Additionally, steady-state computational fluid dynamics (CFD) simulations were conducted and the results are in general good agreement with the experimental data. Overall, the results indicate high fuel flexibility of the combustor, as well as the ability to comply with the NOx emissions limits for a larger range of operating points, compared to that of the previously tested combustors.
Radiographic Nondestructive Testing Simulations Using gate Software Toolkit
Authors: Taha Eslam , Mohammed M. S. , Banoqitah Essam 
Published: September 2019

Abstract
A workspace is created within the geant4 Application for Tomographic Emission (gate) software toolkit for radiographic nondestructive testing (NDT) simulations. The workspace contains models for X-ray and gamma ray emissions, test sample geometries, radiation interaction with the test sample, and image receptors to afford a radiographic NDT setup. The setup is then evaluated by simulating radiographic testing (RT) of stainless-steel step-wedges and a carbon steel flawed welded plate. The results are validated by comparing a simulated step-wedge image to an experimental radiograph. The workspace can be advantageous to the industrial radiography specialists who are unfamiliar with medical imaging software. Running the simulation does not require working knowledge of gate; the open-source software toolkit.
Effect of incretin-based therapies on cancers of digestive system among 101 595 patients with type 2 diabetes mellitus: a systematic review and network meta-analysis combining 84 trials with a median duration of 30 weeks
Authors: Chai Sanbao , Yu Shuqing , Yang Zhirong , Wu Shanshan , Gao Le , Wang Haining , Zhang Yuan , Zhan Siyan , Ji Linong , Sun Feng 
Published: September 2019

ObjectivesTo evaluate the risk of cancers of digestive system with incretin-based therapies among patients with type 2 diabetes mellitus.Research design and methodsMedline, Embase, Cochrane Library and ClinicalTrials.gov databases were searched for randomized controlled clinical trials that compared incretin-based drugs with placebo or other antidiabetic drugs. Paired reviewers independently screened citations, extracted data and assessed risk of bias of included studies. Network meta-analysis was performed, followed by subgroup analysis. The Grading of Recommendations Assessment, Development and Evaluation system was used to assess the quality of evidence.ResultsA total of 84 studies (n=101 595) involving cancers of digestive system were identified (a median follow-up of 30 weeks). The risk of cancers of digestive system with incretin-based therapies was comparable with insulin (OR: 0.86, 95% CI 0.27 to 2.69), metformin (OR: 0.32, 95% CI 0.07 to 1.38), sodium-glucose co-transporter 2 (OR: 5.26, 95% CI 0.58 to 47.41), sulfonylureas (OR: 1.27, 95% CI 0.68 to 2.39), thiazolidinediones (OR: 0.42, 95% CI 0.13 to 1.42), alpha-glucosidase inhibitors (OR: 2.98, 95% CI 0.12 to 73.80), and placebo (OR: 0.87, 95% CI 0.71 to 1.05). The results of subgroup analysis based on the type of digestive system cancers indicated that incretin-based therapies did not increase the risk of gastrointestinal cancers, respectively. The results of subgroup analysis based on age, duration, mean HbA1c, trial duration, and sample size did not indicate the risk of digestive system cancers.ConclusionsModerate to high Grading of Recommendations Assessment, Development and Evaluation evidence suggests that incretin-based therapies were not associated with an increased risk of cancer of digestive system in patients with type 2 diabetes mellitus.
A two-level large-volume epidural blood patch protocol for spontaneous intracranial hypotension: retrospective analysis of risk and benefit
Authors: Martin Ryan , Louy Charles , Babu Vijay , Jiang Yi , Far Azita , Schievink Wouter 
Published: September 2019

BackgroundWe report a retrospective analysis of a two-level, variable-volume epidural blood patch (EBP) technique for the treatment of spontaneous intracranial hypotension (SIH).MethodsNinety-four patients with SIH underwent EBPs. Injectate volume was variable and guided by the onset of back pain, radiculopathy or symptoms referable to the EBP. Patients were a responder if no invasive treatment was necessary for SIH symptoms after the first EBP. Baseline patient characteristics, including presenting symptoms and imaging findings, were compared between responders and non-responders. Adverse events were recorded.ResultsThe mean first EBP volume was 45.3±23.2 (range 4–124 mL). The responder rate was 28.7% after the first EBP, improving to 41.5% and 46.8% after a second and third EBP, respectively. Baseline characteristics were similar between groups, except for the greater prevalence of subdural fluid collections in the responder group (48% vs 18%, p=0.003). Two severe complications occurred: transient bilateral paraplegia and cauda equina syndrome from arachnoiditis.ConclusionsOur protocol can be used to treat SIH but carries risks that require meticulous attention. EBP volumes were variable across patients, demonstrating the variability in the elastance of the epidural space. Rigorous monitoring for neurological symptoms is necessary throughout the procedure to limit complications and determine the endpoint of the EBP. We advocate for rigorous confirmation of epidural placement of the EBP with contrast-imaging studies to limit intrathecal placement of blood, which can lead to arachnoiditis. Randomized controlled trials are needed to determine the safety and efficacy of large-volume EBPs.
Thoracic spinal cord neuromodulation obtunds dorsal root ganglion afferent neuronal transduction of the ischemic ventricle
Authors: Salavatian Siamak , Ardell Sarah M. , Hammer Mathew , Gibbons David , Armour J. Andrew , Ardell Jeffrey L. 
Published: September 2019

Aberrant afferent signaling drives adverse remodeling of the cardiac nervous system in ischemic heart disease. The study objective was to determine whether thoracic spinal dorsal column stimulation (SCS) modulates cardiac afferent sensory transduction of the ischemic ventricle. In anesthetized canines ( n = 16), extracellular activity generated by 62 dorsal root ganglia (DRG) soma (T1-T3), with verified myocardial ischemic (MI) sensitivity, were evaluated with and without 20-min preemptive SCS (T1-T3 spinal level; 50 Hz, 90% motor threshold). Transient MI was induced by 1-min coronary artery occlusion (CAO) of the left anterior descending (LAD) or circumflex (LCX) artery, randomized as to sequence. LAD and LCX CAO activated cardiac-related DRG neurons (LAD: 0.15 ± 0.04–1.05 ± 0.20 Hz, P < 0.00002; LCX: 0.08 ± 0.02–1.90 ± 0.45 Hz, P < 0.0003). SCS decreased basal neuronal activity of neurons that responded to LAD (0.15 ± 0.04 to 0.02 ± 0.01 Hz, P < 0.006) and LCX (0.08 ± 0.02 to 0.02 ± 0.01 Hz, P < 0.003). SCS suppressed responsiveness to transient MI (LAD: 1.05 ± 0.20–0.03 ± 0.01 Hz; P < 0.0001; LCX: 1.90 ± 0.45–0.03 ± 0.01 Hz; P < 0.001). Suprathreshold SCS (1 Hz) did not activate DRG neurons antidromically ( n = 10 animals). Ventricular fibrillation (VF) was associated with a rapid increase in DRG activity to a maximum of 4.39 ± 1.07 Hz at 20 s after VF induction and a return to 90% of baseline within 10 s thereafter. SCS obtunds the capacity of DRG ventricular neurites to transduce the ischemic myocardium to second-order spinal neurons, a mechanism that would blunt reflex sympathoexcitation to myocardial ischemic stress, thereby contributing to its capacity to cardioprotect. NEW & NOTEWORTHY Aberrant afferent signaling drives adverse remodeling of the cardiac nervous system in ischemic heart disease. This study determined that thoracic spinal column stimulation (SCS) obtunds the capacity of dorsal root ganglia ventricular afferent neurons to transduce the ischemic myocardium to second-order spinal neurons, a mechanism that would blunt reflex sympathoexcitation to myocardial ischemic stress. This modulation does not reflect antidromic actions of SCS but likely reflects efferent-mediated changes at the myocyte-sensory neurite interface. Listen to this article’s corresponding podcast at https://ajpheart.podbean.com/e/spinal-cord-stimulation-blunts-dorsal-root-transduction-of-the-ischemic-ventricle/ .
ddeeper Than Deep: Can ddPCR Predict Successful Imatinib Cessation?
Authors: Yan Dongqing , Pomicter Anthony D. , O'Hare Thomas , Deininger Michael W. 
Published: September 2019

Abstract
BCR-ABL1 transcripts at imatinib cessation were quantified by droplet digital PCR (ddPCR) for 175 patients on the STIM2 trial. Patients with BCR-ABL1 transcripts below a defined cutoff had a 12-month molecular recurrence rate of 46% versus 68% for those above the cutoff. Implications of using ddPCR in forecasting successful imatinib cessation are discussed.
See related article by Nicolini et al., p. 6606
Identification of Expression Profiles Defining Distinct Prognostic Subsets of Radioactive-Iodine Refractory Differentiated Thyroid Cancer from the DECISION Trial
Authors: Capdevila Jaume , Matos Ignacio , Mancuso Francesco M. , Iglesias Carmela , Nuciforo Paolo , Zafon Carles , Palmer Hector G. , Ogbah Zighereda , Muiños Laura , Hernando Jorge , Villacampa Guillermo , Peña Carol E. , Tabernero Josep , Brose Marcia S. , Schlumberger Martin , Vivancos Ana 
Published: September 2019

Abstract
Several biomarkers have been suggested to have prognostic value in differentiated thyroid carcinomas (DTC) with no validation in the refractory setting, including all tumor subtypes. We aim to correlate RNA expression profiles with survival based on patients included in the DECISION trial. We obtained 247 samples from the 417 patients included in the DECISION study and performed RNAseq analysis (77 million paired-end reads for each sample on HiSeq2000). After quality control, 125 samples were included in the secondary analysis and mapped against the human reference genome (GRCh38) with STAR (v2.5.1b) using ENCODE parameter. Survival analysis was calculated using the Kaplan–Meier method and log-rank test was used for statistical comparison. In this post hoc analysis, we identified three groups of tumors based on their gene expression profile: BRAF-like, RAS-like, and non-BRAF-non-RAS-like (NoBRaL). No significant correlation with sorafenib responders was observed. However, we identified a statistically significant correlation between the RNA-expression profiles and progression-free survival. The BRAF-like profile had a significantly better outcome compared with RAS-like and NoBRaL (11.8, 6.2, and 5.5 months, respectively) [HR: 0.31, 95% confidence interval (CI), 0.17–0.60; P &lt; 0.001 and HR: 0.36 (95% CI, 0.21–0.63); P &lt; 0.001] and HR: 0.36 (95% CI, 0.21–0.63; P &lt; 0.001) and maintained significance as an independent prognostic factor for overall survival in the multivariate analysis for papillary thyroid cancers. To our knowledge, this is the first comprehensive RNA-seq analysis of all histologic subtypes of DTC. The RNA expression profiles identified may suggest a new prognostic parameter to be considered before recommendation of systemic therapies or the design of stratification factors for future clinical trials.