bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-operative AICS status in completely resected lung cancer patients with pre-operative AICS abnormalities: predictive significance of disease recurrence
Authors: Anayama Takashi , Higashiyama Masahiko , Yamamoto Hiroshi , Kikuchi Shinya , Ikeda Atsuko , Okami Jiro , Tokunaga Toshiteru , Hirohashi Kentaro , Miyazaki Ryohei , Orihashi Kazumasa 
Published: August 2018

AbstractThe AminoIndexTM Cancer Screening (AICS) system, a plasma-free amino acid (PFAA)-based multivariate discrimination index, is a blood screening test for lung cancer based on the comparison of PFAA concentrations between patients with lung cancer and healthy controls. Pre- and post-operative AICS values were compared among 72 patients who underwent curative resection for lung cancer. Post-operative changes in PFAA concentrations were also evaluated. AICS values were classified as rank A (0.0–4.9), B (5.0–7.9), or C (8.0–10.0). Rank B–C patients were evaluated for outcomes and post-operative changes in their AICS values. Twenty-three of the 44 pre-operative rank B–C patients experienced post-operative reductions in AICS rank. Only one patient experienced cancer recurrence. Post-operative changes in PFAA concentrations were associated with the risk of post-operative cancer recurrence (p = 0.001). Multivariate analysis revealed that the absence of a post-operative reduction in AICS rank independently predicted cancer recurrence (hazard ratio: 14.28; p = 0.012). The majority of patients had high pre-operative AICS values and exhibited a reduction in AICS rank after curative resection. However, the absence of a post-operative reduction in AICS rank was associated with cancer recurrence, suggesting that AICS rank may be a sensitive marker of post-operative recurrence.
Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank
Authors: Loftfield Erikka , Zhou Weiyin , Graubard Barry I. , Yeager Meredith , Chanock Stephen J. , Freedman Neal D. , Machiela Mitchell J. 
Published: August 2018

AbstractMosaic loss of the Y chromosome (mLOY) is the most commonly reported large structural somatic event. Previous studies have indicated age and cigarette smoking increase the risk of mLOY, but the relationship of other exposures with mLOY and mLOY with disease has not been adequately investigated. We characterized mLOY in a large cohort of 223,338 men from the UK Biobank by scanning for deviations in genotyping array median log2 intensity ratios (mLRR) of the Y chromosome using a standard algorithm. A total of 3,789 (1.7%) men showed evidence for mLOY (mLRR < −0.15). In multivariable-adjusted logistic regression models, we found that mLOY increases exponentially with age (overall P-value < 4.9 × 10−324; p-value for the quadratic term = 2.1 × 10−7), and observed a strong association with current smoking (P-value = 7.8 × 10−184). We observed less mLOY in men of African ancestry (0.4%) compared to men of European ancestry (1.8%, P-value = 0.003). Although mLOY was not associated with prevalent cancer (P-value = 0.61), associations were observed for diabetes (P-value = 0.003) and cardiovascular disease (P-value = 0.01). Using Cox proportional hazards regression models, mLOY was associated with all-cause mortality among men with a high proportion of cells affected (mLRR < −0.40; HR = 1.35, 95% CI = 1.08–1.70, P-value = 0.009). In conclusion, mLOY was associated with several health-related factors as well as with all-cause mortality. Further functional studies are warranted to understand how and in what way mLOY could influence adult male health.
Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology
Authors: Simon Matthew J. , Wang Marie X. , Murchison Charles F. , Roese Natalie E. , Boespflug Erin L. , Woltjer Randall L. , Iliff Jeffrey J. 
Published: August 2018

AbstractThe deposition of misfolded proteins, including amyloid beta plaques and neurofibrillary tangles is the histopathological hallmark of Alzheimer’s disease (AD). The glymphatic system, a brain-wide network of perivascular pathways that supports interstitial solute clearance, is dependent upon expression of the perivascular astroglial water channel aquaporin-4 (AQP4). Impairment of glymphatic function in the aging rodent brain is associated with reduced perivascular AQP4 localization, and in human subjects, reduced perivascular AQP4 localization is associated with AD diagnosis and pathology. Using human transcriptomic data, we demonstrate that expression of perivascular astroglial gene products dystroglycan (DAG1), dystrobrevin (DTNA) and alpha-syntrophin (SNTA1), are associated with dementia status and phosphorylated tau (P-tau) levels in temporal cortex. Gene correlation analysis reveals altered expression of a cluster of potential astrocytic endfoot components in human subjects with dementia, with increased expression associated with temporal cortical P-tau levels. The association between perivascular astroglial gene products, including DTNA and megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) with AD status was confirmed in a second human transcriptomic dataset and in human autopsy tissue by Western blot. This suggests changes in the astroglial endfoot domain may underlie vulnerability to protein aggregation in AD.
Terrestrial exposure of a fresh Martian meteorite causes rapid changes in hydrogen isotopes and water concentrations
Authors: Stephant Alice , Garvie Laurence A. J. , Mane Prajkta , Hervig Richard , Wadhwa Meenakshi 
Published: August 2018

AbstractDetermining the hydrogen isotopic compositions and H2O contents of meteorites and their components is important for addressing key cosmochemical questions about the abundance and source(s) of water in planetary bodies. However, deconvolving the effects of terrestrial contamination from the indigenous hydrogen isotopic compositions of these extraterrestrial materials is not trivial, because chondrites and some achondrites show only small deviations from terrestrial values such that even minor contamination can mask the indigenous values. Here we assess the effects of terrestrial weathering and contamination on the hydrogen isotope ratios and H2O contents of meteoritic minerals through monitored terrestrial weathering of Tissint, a recent Martian fall. Our findings reveal the rapidity with which this weathering affects nominally anhydrous phases in extraterrestrial materials, which illustrates the necessity of sampling the interiors of even relatively fresh meteorite falls and underlines the importance of sample return missions.
Physiologically based pharmacokinetic modelling of atomoxetine with regard to CYP2D6 genotypes
Authors: Kim Se-Hyung , Byeon Ji-Young , Kim Young-Hoon , Lee Choong-Min , Lee Yun Jeong , Jang Choon-Gon , Lee Seok-Yong 
Published: August 2018

AbstractAtomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further glucuronidation to an inactive 4-HAT-O-glucuronide. Clinical trials have shown that decreased CYP2D6 activity leads to substantially elevated atomoxetine exposure and increase in adverse reactions. The aim of this study was to to develop a pharmacologically based pharmacokinetic (PBPK) model of atomoxetine in different CYP2D6 genotypes. A single 20 mg dose of atomoxetine was given to 19 healthy Korean individuals with CYP2D6*wt/*wt (*wt = *1 or *2) or CYP2D6*10/*10 genotype. Based on the results of this pharmacokinetic study, a PBPK model for CYP2D6*wt/*wt individuals was developed. This model was scaled to those with CYP2D6*10/*10 genotype, as well as CYP2D6 poor metabolisers. We validated this model by comparing the predicted pharmacokinetic parameters with diverse results from the literature. The presented PBPK model describes the pharmacokinetics after single and repeated oral atomoxetine doses with regard to CYP2D6 genotype and phenotype. This model could be utilized for identification of appropriate dosages of atomoxetine in patients with reduced CYP2D6 activity to minimize the adverse events, and to enable personalised medicine.
Barn swallows long-distance migration occurs between significantly temperature-correlated areas
Authors: Pancerasa Mattia , Ambrosini Roberto , Saino Nicola , Casagrandi Renato 
Published: August 2018

AbstractOrganisms are routinely confronted with crucial decisions on the best time and place to perform fundamental activities. However, unpredictable spatio-temporal variation in ecological factors makes life-history optimization difficult particularly for long-distance migrants, which are putatively blind of conditions thousands of kilometers and weeks ahead along their journey. Here we challenge, on a hierarchy of geographical scales, the common wisdom that migratory birds have no clue to ecological conditions at destination. Using ringing data of the inter-continental migrating barn swallow (Hirundo rustica), we show that temperatures at breeding sites and at times of arrival from migration are more correlated with those at actual wintering sites and at times of departure than with those at other sites and at periods before/after departure. Hence, individual swallows have clues to adjust timing of spring migration based on expected conditions at destination, and they apparently choose wintering sites to increase availability of such information.
Deep soil water storage varies with vegetation type and rainfall amount in the Loess Plateau of China
Authors: Cao Ruixue , Jia Xiaoxu , Huang Laiming , Zhu Yuanjun , Wu Lianhai , Shao Ming’an 
Published: August 2018

AbstractSoil-water storage in a deep soil layer (SWSD), defined as the layer where soil water is not sensitive to daily evapotranspiration and regular rainfall events, functions as a soil reservoir in China’s Loess Plateau (LP). We investigated spatial variations and factors that influence the SWSD in the 100–500 cm layers across the entire plateau. SWSD generally decreased from southeast to northwest following precipitation gradient, with a mean value of 587 mm. The spatial variation in the SWSD in grassland was the highest, followed by protection forests, production forests and cropland. Variation in the >550 mm rainfall zone was much lower than that in the <550 mm zone. The significant influencing variables explained 22.3–65.2% of the spatial variation in SWSD. The joint effect of local and climatic variables accounted for most of the explained spatial variation of SWSD for each vegetation type and the <450 mm rainfall zone. Spatial variation of SWSD, however, was dominantly controlled by the local variables in the 450–550 and the >550 mm rainfall zones. Therefore, regional models of SWSD for a specific vegetation need to incorporate climatic, soil and topographic variables, while for a rainfall zone, land use should not be ignored.
Simple rules for construction of a geometric nest structure by pufferfish
Authors: Mizuuchi Ryo , Kawase Hiroshi , Shin Hirofumi , Iwai Daisuke , Kondo Shigeru 
Published: August 2018

AbstractA small (~10 cm) male pufferfish (Torquigener albomaculosus) builds a large (~2 m) sandy nest structure, resembling a mysterious crop circle, to attract females. The circle consists of radially arranged deep ditches in the outer ring region, and maze-like shallow ditches in the central region. The configuration is geometrical. Here, we examined the process of the outer ring construction, and extracted the ‘rules’ followed by the pufferfish. During construction, the pufferfish repeatedly excavates ditches from the outside in. Generally, excavation starts at lower positions, and occurs in straight lines. The entry position, the length, and the direction of each ditch were recorded. A simulation program based on these data successfully reproduced the circle pattern, suggesting that the complex circle structure can be created by the repetition of simple actions by the pufferfish.
Augmentation of leaf color parameters, pigments, vitamins, phenolic acids, flavonoids and antioxidant activity in selected Amaranthus tricolor under salinity stress
Authors: Sarker Umakanta , Oba Shinya 
Published: August 2018

AbstractAmaranthus tricolor genotype VA13 was evaluated under four salinity stress in terms of color parameters, leaf pigments, β-carotene, vitamin C, TPC, TFC, TAC, phenolic acids and flavonoids. Salinity stress significantly increases all the studied traits. The increments of all these compounds were high under moderate and severe salinity stress compared to control condition. In this study, trans-cinnamic acid was newly identified phenoic acid in A. tricolor. Salicylic acid, vanilic acid, trans-cinnamic acid, gallic acid, chlorogenic acid, rutin, isoquercetin and m-coumaric acid were the most abundant phenolic compounds of amaranth that increased with the severity of salinity stress. A. tricolor leaves are good source of pigments, β-carotene, vitamin C, bioactive compounds, phenolic acids, flavonoids and antioxidants. In salt-stressed amaranth, correlation studies revealed strong antioxidant activity of leaf pigments, β-carotene, vitamin C, TPC, TFC. These bioactive compounds played a vital role in scavenging ROS and could be beneficial to human nutrition by serving as a good antioxidant and antiaging source in human health benefit. A. tricolor cultivated under salinity stress conditions can contribute a high quality of the final product in terms of leaf pigments, bioactive compounds, phenolic acids, flavonoids and antioxidants. It can be a promising alternative crop in saline-prone areas.
Visual Processing by Calretinin Expressing Inhibitory Neurons in Mouse Primary Visual Cortex
Authors: Camillo Daniela , Ahmadlou Mehran , Saiepour M. Hadi , Yasaminshirazi Maryam , Levelt Christiaan N. , Heimel J. Alexander 
Published: August 2018

AbstractInhibition in the cerebral cortex is delivered by a variety of GABAergic interneurons. These cells have been categorized by their morphology, physiology, gene expression and connectivity. Many of these classes appear to be conserved across species, suggesting that the classes play specific functional roles in cortical processing. What these functions are, is still largely unknown. The largest group of interneurons in the upper layers of mouse primary visual cortex (V1) is formed by cells expressing the calcium-binding protein calretinin (CR). This heterogeneous class contains subsets of vasoactive intestinal polypeptide (VIP) interneurons and somatostatin (SOM) interneurons. Here we show, using in vivo two-photon calcium imaging in mice, that CR neurons can be sensitive to stimulus orientation, but that they are less selective on average than the overall neuronal population. Responses of CR neurons are suppressed by a surrounding stimulus, but less so than the overall population. In rats and primates, CR interneurons have been suggested to provide disinhibition, but we found that in mice their in vivo activation by optogenetics causes a net inhibition of cortical activity. Our results show that the average functional properties of CR interneurons are distinct from the averages of the parvalbumin, SOM and VIP interneuron populations.
The prognostic values of the peroxiredoxins family in ovarian cancer
Authors: Li Saisai , Hu Xiaoli , Ye Miaomiao , Zhu Xueqiong 
Published: August 2018

Purpose: Peroxiredoxins (PRDXs) are a family of antioxidant enzymes with six identified mammalian isoforms (PRDX1–6). PRDX expression is up-regulated in various types of solid tumors; however, individual PRDX expression, and its impact on prognostic value in ovarian cancer patients, remains unclear.
Methods: PRDXs family protein expression profiles in normal ovarian tissues and ovarian cancer tissues were examined using the Human Protein Atlas database. Then, the prognostic roles of PRDX family members in several sets of clinical data (histology, pathological grades, clinical stages, and applied chemotherapy) in ovarian cancer patients were investigated using the Kaplan–Meier plotter.
Results: PRDXs family protein expression in ovarian cancer tissues was elevated compared with normal ovarian tissues. Meanwhile, elevated expression of PRDX3, PRDX5, and PRDX6 mRNAs showed poorer overall survival (OS); PRDX5 and PRDX6 also predicted poor progression-free survival (PFS) for ovarian cancer patients. Furthermore, PRDX3 played significant prognostic roles, particularly in poor differentiation and late-stage serous ovarian cancer patients. Additionally, PRDX5 predicted a lower PFS in all ovarian cancer patients treated with Platin, Taxol, and Taxol+Platin chemotherapy. PRDX3 and PRDX6 also showed poor PFS in patients treated with Platin chemotherapy. Furthermore, PRDX3 and PRDX5 indicated lower OS in patients treated with these three chemotherapeutic agents. PRDX6 predicted a poorer OS in patients treated with Taxol and Taxol+Platin chemotherapy.
Conclusion: These results suggest that there are distinct prognostic values of PRDX family members in patients with ovarian cancer, and that the expression of PRDX3, PRDX5, and PRDX6 mRNAs are a useful prognostic indicator in the effect of chemotherapy in ovarian cancer patients.
Molecular gas content in obscured AGN at z > 1
Authors: Perna M. , Sargent M. T. , Brusa M. , Daddi E. , Feruglio C. , Cresci G. , Lanzuisi G. , Lusso E. , Comastri A. , Coogan R. T. , D’Amato Q. , Gilli R. , Piconcelli E. , Vignali C. 
Published: August 2018

Aims. The standard active galactic nuclei (AGN)-galaxy co-evolutionary scenario predicts a phase of deeply “buried” supermassive black hole growth coexisting with a starburst (SB) before feedback phenomena deplete the cold molecular gas reservoir of the galaxy and an optically luminous quasar (QSO) is revealed (called the SB-QSO evolutionary sequence). The aim of this work is to measure the cold gas reservoir of three highly obscured QSOs to test if their gas fraction is similar to that of submillimetre galaxies (SMGs), as expected by some models, and to place these measurements in the context of the SB-QSO framework.
Methods. We target CO(1-0) transition in BzK4892, a Compton thick (CT) QSO at z = 2.6, CO(1-0) in BzK8608 and CO(2-1) in CDF153, two highly obscured (NH ≈ 6 × 1023 cm−2) QSOs at z = 2.5 and z = 1.5, respectively. For these targets, we place 3σ upper limits on the CO lines, with L′CO < (1.5 ÷ 2.8)×1010 K km s−1 pc2. We also compare the molecular gas conditions of our targets with those of other systems at z > 1, considering normal star-forming galaxies and SMGs, and unobscured and obscured AGN from the literature. For the AGN samples, we provide an updated and almost complete collection of targets with CO follow-up at z > 1.
Results. BzK4892 displays a high star formation efficiency (SFE = LIR/L′CO > 410 L⊙/(K km s−1 pc2 )) and a gas fraction fgas = Mgas/(Mstar + Mgas)< 10%. Less stringent constraints are derived for the other two targets (fgas < 0.5 and SFE > 10 L⊙/(K km s−1 pc2 )). From the comparison with the literature data we found that, on average, i) obscured AGN at z > 1 are associated with higher SFE and lower fgas with respect to normal star-forming galaxies and SMGs; ii) mildly and highly obscured active galaxies have comparable gas fractions; iii) the SFE of CT and obscured AGN are similar to those of unobscured AGN.
Conclusions. Within the SB-QSO framework, these findings could be consistent with a scenario where feedback can impact the host galaxy already from the early phases of the SB-QSO evolutionary sequence.
Shared nomenclature and identifiers for telescopes and instruments
Authors: Perret Emmanuelle , Louys Mireille , Buga Mihaela , Lesteven Soizick 
Published: August 2018

In the context of sharing public data, science results are expected to be reproducible and therefore we need full traceability of the origin of the data. On the documentalist side, there is a need to relate instrumental origins to the published data.
We propose to define a shared nomenclature to index each publication with unique designations for facilities, telescopes and instruments which could benefit from the Virtual Observatory work on semantics.
This would help the documentalists to check the consistency of the instrument description in publications or make it more explicit. Observation period, data quality and spectral coverage, for instance, may be checked by referencing a global instrumentation service which gathers the nominal observation parameters for the telescope/facility/instrument involved.
Based on this indexation mechanism, then the bibliographic metrics for telescope /instrument usage would be easy to compute, and tracking services like the ESO telescope bibliography database (TelBib) or others would be easier to feed. This paper traces the existing initiatives and gives the example of a facility description framework reusing Virtual Observatory metadata which could be fed by the community.
Evaluating High Impact Papers: Are We Missing Something?
Authors: Winkelman Sherry , Rots Arnold , D’Abrusco Raffaele 
Published: August 2018

The bibliographic science papers with high citations rates are often used as an indication of the science impact of an observatory. These high impact papers are presented as examples of the best science being done with an observatory’s data. But, is the number of citations by itself a good indicator of the scientific impact of the paper, and is impact a good indicator of the scientific impact of the observatory? In this paper we will present results from a recent study of Chandra high impact papers and suggest some alternative methods for identifying such papers.
This work has been supported by NASA under contract NAS 8-03060 to the Smithsonian Astrophysical Observatory for operation of the Chandra X-ray Center.
A Model for Using DataCite DOIs in Observatory Bibliographies
Authors: Rots Arnold , D’ Abrusco Raffaele , Winkelman Sherry 
Published: August 2018

The use of DOI persistent identifiers has become an attractive mechanism for citing datasets in articles. However, taking the users’ interests into account requires careful consideration of the way in which we apply these identifiers.
Our objective is the application of DOIs in such a way that individual datasets are properly cited while presenting the citations to the reader in a user-friendly manner.
This is achieved by making judicious use of the metadata structure provided by DataCite.
La voix de Dieu et les mains de Bispo
Authors: Birman Joël 
Published: August 2018

L’auteur explore le parcours créatif du peintre Arthur Bispo do Rosario. Il tient compte du projet qui est au principe de cette création picturale, soit « l’impératif du sacré ». L’artiste, peu soucieux de sa notoriété, ou du succès mercantile que pouvait rencontrer son travail a toujours déclaré clairement que tout ce qu’il avait réalisé n’était qu’une conséquence et un dédoublement de la voix de Dieu, qui s’imposait à lui comme un impératif incontournable. Bispo non seulement nommait chacune de ses pièces, mais il les numérotait aussi, souhaitant par là effectuer de façon détaillée l’inventaire qui lui avait été religieusement commandé. Bispo a connu une histoire psychiatrique pénible. L’auteur défend la thèse selon laquelle Bispo a activement résisté aux processus de psychiatrisation de son existence à travers la confection de son œuvre picturale, en s’appropriant une partie de l’espace de l’asile pour en faire un atelier d’art. Malgré la violence des procédés asilaires auxquels il était soumis, Bispo s’est avéré un véritable survivant, en plus d’avoir forgé une œuvre picturale de grande envergure.
Au terme d’une présentation soignée de la biographie de l’artiste, l’auteur affirme que malgré le fait d’être effectivement inscrit dans le champ de la folie et d’avoir passé une bonne partie de sa vie à l’asile, Bispo a bel et bien réalisé une production artistique.