bluuebunny/crossref_metadata_2025_split huggingface dataset:
National Study Examining Excellence and Value in Physical Therapist Residency Education: Part 1—Design, Methods, and Results
Authors: Briggs Matthew S , Osborne Raine , Hartley Gregory W , Kraft Sara , Bailey Chloe E , Tichenor Carol Jo , Rapport Mary Jane , Black Lisa , Jensen Gail 
Published: November 2024

Abstract

Objective
A challenge in health professions is training practitioners to navigate health care complexities, promote health, optimize outcomes, and advance their field. Physical therapist residency education offers a pathway to meet these needs in ways that “entry-level” (professional) education may not. Identifying key aspects of excellence in residency education and understanding its value in developing adaptive expertise will help devise strategies to enhance program, resident, and patient outcomes. The objective of this study was to examine current physical therapist residency education practices to identify and describe examples of excellence and value.

Methods
A multi-site, multi-specialty qualitative case series was conducted, examining exemplary physical therapist residency programs and their contextual environments using a social constructivist theoretical lens. Six residency programs operating 20 individual residencies that were considered exemplar were selected for the study to participate in site visits. Qualitative case studies were generated from individual interviews, focus groups, review of artifacts, and field observations. The residencies were diverse in specialty area of practice, setting, and geographic location.

Results
A conceptual framework was generated grounded in the domains of excellence and value. These domains were connected by 3 signature indicators: (1) atmosphere of practice-based learning, (2) embodiment of professional formation, and (3) elevated practice. These signature indicators represent the aggregate effects of the interchange between the excellence and value domains which sustain residency education.

Conclusion
This study builds upon the work of the Physical Therapist Education for the 21st Century (PTE-21) study and identifies key elements of excellence in residency education, the value of such education, and related outcomes. Findings from this study substantiate the need for a postprofessional phase of physical therapist education founded in practice-based learning encapsulated in residency education.

Impact
Results from this study could have compelling and powerful implications on the dialogue and strategic direction in physical therapist residency education.
Silent St. Louis encephalitis virus circulation evidence by a haemovigilance survey in a centralized blood bank
Authors: Blanco Sebastián , Frutos María C , Spinsanti Lorena , Gallego Sandra V 
Published: November 2024

ABSTRACT

Background
Saint Louis encephalitis virus (SLEV) re-emergence and its geographical expansion, evidenced by its emergence in previously unaffected areas, have raised significant public health concerns. We aimed to show the usefulness of haemovigilance as an effective tool to fill arboviruses surveillance gaps to track trends and identify hotspots.

Methods
Within the framework of a blood bank haemovigilance program, we performed a survey to evaluate the potential threat of circulating mosquito-borne infections for transfusion safety. SLEV was detected by a PCR targeting the conserved NS5-gene region, and the PCR-product was subjected to direct nucleotide sequencing reaction.

Results
The SLEV-strain detected in the blood donor (OR236721) clustered with previously reported CbaAr-4005, 79 V-2533, and MN413675 isolated in Córdoba (2005, epidemic), Santa Fe (1979, non-epidemic) and Buenos Aires (2013, non-epidemic), with 97% identity.

Conclusions
Herein, we show the usefulness of haemovigilance in uncovering the silent circulation of arboviral infections. Implementing this systematic surveillance approach would allow for monitoring the distribution and incidence of vector-borne diseases, providing information that could prevent the spread of the virus and its introduction into novel biomes. Ultimately, leveraging haemovigilance enables timely identification of potential outbreaks and empowers policymakers to make well-informed decisions to safeguard public health.
Public/Private Religion in Context: When Psychologists Use Religion to Invigorate Therapy
Authors: Tal Orly , Pagis Michal 
Published: November 2024

Abstract
Previous studies have tracked how the penetration of psychological discourses into the religious sphere turns religion into a private, individual matter. These studies, however, overlook a process that is moving in the opposite direction—the influence of religion on psychology. Based on ethnographic research among licensed psychotherapists who integrate Buddhist or Jewish traditions into their clinical practice, we demonstrate that processes of privatization and de-privatization can take place simultaneously depending on context. In the setting of institutional training and professional gatherings, religion is visible and is used to produce a public, social, and moral vision for an invigorated psychology. By contrast, in the dyadic setting between psychotherapist and patient, religion is kept covert, and while it is significant to the psychotherapist in his/her practice, it remains invisible to the patient. Yet, despite its covert role in the clinical setting, psychotherapists see religion as having a broader ripple impact. We offer the notions of overt and covert sacralization to characterize how religion influences the field of psychology and discuss the implications of this study for the public/private debate.
Phase 2, Multicenter, Open-label, Nonrandomized Study of Neoadjuvant Chemotherapy Liposomal Irinotecan With 5-Fluorouracil, Leucovorin, and Oxaliplatin, Followed by Chemoradiotherapy in Patients With Rectal Cancer in a Watch-and-Wait Program
Authors: Muñoz César , Riesco Martinez María-C. , Ugidos Lisardo , García-Alfonso Pilar , Alvarez-Gallego Rafael , Peinado Paloma , Toledano Carmen , Mihic-Góngora Luka , Ortega Anselmi Justo Gabriel , Sanz Garcia Enrique , Vicente Emilio , Quijano Yolanda , Durán Hipólito J. , Díaz Eduardo , Ferri Valentina , Rubio Carmen , HernandoRequejo Ovidio , López González Mercedes , Prados Susana , López Ulpiano , Allona María , PérezDueñas Virginia , Perez-Escutia María Angeles , Cubillo Antonio 
Published: November 2024

Objective:
To evaluate the efficacy of neoadjuvant chemotherapy combination with liposomal irinotecan, 5-fluorouracil, leucovorin, and oxaliplatin in patients with locally advanced rectal cancer.

Methods:
This was a phase 2, nonrandomized, multicenter study in adults with stage II or III rectal cancer and an Eastern Cooperative Oncology Group performance status of 0 to 1. Total neoadjuvant therapy (TNT) consisted of neoadjuvant chemotherapy combination with liposomal irinotecan (60 mg/m2), oxaliplatin (60 mg/m2), leucovorin (400 mg/m2), and fluorouracil (2400 mg/m²), followed by chemoradiotherapy [ie, capecitabine (825 mg/m2) and radiotherapy according to the standard of care]. The primary efficacy endpoint was the proportion of patients who achieved clinical complete response (cCR), defined as the normalization of pelvic magnetic resonance imaging, rectoscopy, computed tomography scan, and tumor markers.

Results:
The median follow-up was 32.3 months. Of the 30 patients who underwent TNT and were evaluated, 6 (20.0%; 95% CI: 5.2%-34.8%) patients achieved a cCR. There were no deaths. The median disease-free survival (DFS) for patients with cCR was not reached after a follow-up of 32 months; the 1-year DFS rate was 90.0% (95% CI: 71.0%-100%), and the 2-year and 3-year DFS rates were 80.0% (95% CI: 55.0%-100%). No grade ≥4 adverse events (AEs) were observed. Grade 3 AEs occurred in 18 patients (60%), most frequent was diarrhea (n = 9, 30%). Eleven (36.7%) patients experienced serious AEs, with diarrhea being the most frequent (n = 6, 20.0%).

Conclusion:
TNT with 5-fluorouracil, leucovorin, and oxaliplatin and chemoradiation is a safe and effective therapeutic alternative for the management of locally advanced rectal cancer.
Clinical management of hypophosphatemic osteomalacia induced by adefovir and tenofovir: Insights from a case report
Authors: He Yinhui , Huang Xin , Ye Yongjun , Xu Haiyan 
Published: November 2024

Rationale:
Hypophosphatemic osteomalacia is a rare chronic metabolic bone disease characterized by low serum phosphate levels owing to genetic or acquired causes. This article presents a case report of the clinical management, challenges encountered, and prognosis of secondary hypophosphatemic osteomalacia induced by defovir and tenofovir.

Patient concerns:
A 55-year-old male patient had been experiencing persistent dull chest pain and fatigue for more than a year. The patient had chronic hepatitis B infection for over 10 years, with regular use of adefovir dipivoxil capsules for more than 10 years. Five months before admission, the patient was switched to tenofovir alafenamide fumarate tablets.

Diagnoses:
After obtaining clinical manifestations, medical history, and examination results, tumor-induced osteomalacia was excluded, and the final diagnosis was drug-induced hypophosphatemic osteomalacia.

Interventions:
Adefovir dipivoxil and tenofovir alafenamide were discontinued, and the patient was switched to entecavir disintegration tablets for antiviral therapy. He was advised to follow a high-phosphate diet, receive phosphorus supplementation and calcitriol capsules to promote calcium absorption, obtain moderate sun exposure, and take measures to prevent falls and fractures.

Outcomes:
Serum phosphate levels showed a gradual upward trend, with the most recent measurement being 0.85 mmol/L. The bone density gradually improved and reached normal levels in the most recent assessment. The symptoms of fatigue and chest pain were resolved.

Lessons:
Accurate diagnosis requires a combination of clinical presentation, medical history, biochemical and radiological findings, and, if available, measurement of fibroblast growth factor 23 (FGF 23). The role of national, provincial, or regional centers for rare diseases is crucial for conducting unconventional tests and providing access to rare medications.
Growth kinetics of high-grade serous ovarian cancer using longitudinal clinical data - implications for early detection
Authors: Narayanan Bharath , Buddenkote Thomas , Smith Hayley , Shah Mitul , Freeman Susan , Hulse David , Funingana Gabriel , Alcaraz Marie-Lyne , Ortuzar Mireia-Crispin , Brenton James , Pharoah Paul , Pashayan Nora 
Published: November 2024

AbstractHigh-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological cancer with patients routinely diagnosed at advanced stages with widespread disease. Evidence from screening trials indicates that early diagnosis may not reduce cancer-related deaths, possibly due to an underestimation of the true extent of the disease at screening. We aim to characterise the growth kinetics of HGSOC to understand why early detection has failed so far and under what conditions it might prove fruitful.We analysed a dataset of 597 patients with a confirmed HGSOC diagnosis, and identified 37 cases with serial CT scans. We calculated the growth rates of lesions in the ovaries/pelvis and the omentum and estimated the time to metastasis using a population-level Gompertz model. Finally, we simulated ultrasound and CA125 based screening in a virtual population of patients.Growing lesions in the ovaries and the omentum doubled in volume every 2.3 months and 2 months respectively. At both sites, smaller lesions grew faster than larger ones. The 12 cases with growing lesions in both disease sites had a median interval of 11.5 months between disease initiation and the onset of metastasis. Our simulations suggested that over 33% of patients would develop metastases before they could be screen detected. The remaining patients provided a median window of opportunity of only 4.7 months to detect the tumours before they metastasised.Our results suggest that HGSOC lesions have short time to metastasis intervals, preventing effective early detection using current screening approaches.
Tracking Immunity: Increased number of COVID-19 boosters increases the longevity of anti-RBD and anti-RBD neutralizing antibodies
Authors: Hou Ching-Wen , Williams Stacy , Boyle Veronica , Roeder Alexa , Bobbett Bradley , Garcia Izamar , Caruth Giavanna , Magee Mitch , Chung Yunro , Lake Douglas , LaBaer Joshua , Murugan Vel 
Published: November 2024

AbstractBackground/ObjectivesSince the World Health Organization declared COVID-19 a pandemic in March 2020, the virus has caused multiple waves of infection globally. Arizona State University (ASU), the largest four-year university in the United States, offers a uniquely diverse setting for assessing immunity within a large community. This study aimed to evaluate SARS-CoV-2 antibody seroprevalence and the effects of infection and vaccination three years into the pandemic.MethodsA serosurvey was conducted at ASU from January 30 to February 3, 2023. Participants completed questionnaires about demographics, respiratory infection history, symptoms, and COVID-19 vaccination status. Blood samples were analyzed for anti-receptor binding domain (RBD) IgG and anti-nucleocapsid (NC) antibodies, offering a comprehensive view of immunity from both natural infection and vaccination.ResultsThe seroprevalence of anti-RBD IgG antibodies was 96.2% (95% CI: 94.8%-97.2%), and 64.9% (95% CI: 61.9%-67.8%) of participants had anti-NC antibodies. Anti-RBD IgG levels correlated strongly with neutralizing antibody levels, and participants who received more vaccine doses showed higher levels of both anti-RBD IgG and neutralizing antibodies. Increasing number of exposures through vaccination and/or infection resulted in higher and long-lasting antibodies.ConclusionThe high levels of anti-RBD antibodies observed reflect substantial vaccine uptake within this population. Ongoing vaccination efforts, especially as new variants emerge, are essential to maintaining protective antibody levels. These findings underscore the importance of sustained public health initiatives to support broad-based immunity and protection.
Obfuscation via pitch-shifting for balancing privacy and diagnostic utility in voice-based cognitive assessment
Authors: Ahangaran Meysam , Dawalatabad Nauman , Karjadi Cody , Glass James , Au Rhoda , Kolachalama Vijaya B. 
Published: November 2024

AbstractIntroductionDigital voice analysis is gaining traction as a tool to differentiate cognitively normal from impaired individuals. However, voice data poses privacy risks due to the potential identification of speakers by automated systems.MethodsWe developed a framework that uses weighted linear interpolation of privacy and utility metrics to balance speaker obfuscation and cognitive integrity in cognitive assessments. This framework applies pitch-shifting for speaker obfuscation while preserving cognitive speech features. We tested it on digital voice recordings from the Framingham Heart Study (N=128) and Dementia Bank Delaware corpus (N=85), both containing responses to neuropsychological tests.ResultsThe tool effectively obfuscated speaker identity while maintaining cognitive feature integrity, achieving an accuracy of 0.6465 in classifying individuals with normal cognition, mild cognitive impairment, and dementia in the FHS cohort.DiscussionOur approach enables the development of digital markers for dementia assessment while protecting sensitive personal information, offering a scalable solution for privacy-preserving voice-based diagnostics.
Rapid enzymatic assay for antiretroviral drug monitoring using CRISPR-Cas12a enabled readout
Authors: Singh Maya A. , Chang Megan M. , Wang Qin , Rodgers Catherine , Lutz Barry R. , Olanrewaju Ayokunle O. 
Published: November 2024

AbstractMaintaining efficacy of human immunodeficiency virus (HIV) medications is challenging among children because of dosing difficulties, the limited number of approved drugs, and low rates of medication adherence. Drug level feedback (DLF) can support dose optimization and timely interventions to prevent treatment failure, but current tests are heavily instrumented and centralized. We developed the REverse-transcriptase ACTivity-crispR (REACTR) assay for rapid measurement of HIV drugs based on the extent of DNA synthesis by HIV reverse transcriptase. CRISPR-Cas enzymes bind to synthesized DNA, triggering collateral cleavage of quenched reporters and generating fluorescence. We measured azidothymidine triphosphate (AZT-TP), a key drug in pediatric HIV treatment, and investigated the impact of assay time and DNA template length on REACTR’s sensitivity. REACTR selectively measured clinically relevant AZT-TP concentrations in the presence of genomic DNA and peripheral blood mononuclear cell lysate. REACTR has the potential to enable rapid point-of-care HIV DLF to improve pediatric HIV care.
FIDDLE: a deep learning method for chemical formulas prediction from tandem mass spectra
Authors: Hong Yuhui , Li Sujun , Ye Yuzhen , Tang Haixu 
Published: November 2024

AbstractMolecular identification through tandem mass spectrometry is fundamental in metabolomics, with formula identification serving as an initial step in the process. Current computational methods often struggle with accuracy, speed, and scalability for relatively larger molecules, limiting high-throughput workflows. We present FIDDLE (FormulaIDentification byDeepLEarning), a deep learning-based method trained on over 38,000 molecules and 1 million MS/MS spectra from various Quadrupole Time-of-Flight (QTOF) and Orbitrap instruments. FIDDLE accelerates formula identification by more than 10-fold and achieves top-1 and top-5 accuracies of 88.3% and 93.6%, respectively, outperforming state-of-the-art methods based on top-down (SIRIUS) and bottom-up (BUDDY) approaches by over 10%. On external metabolomics datasets, FIDDLE achieves top-3 accuracies of 72.1% (positive ion mode) and 66.2% (negative ion mode), with further improvements to 80.0% and 73.8% when combined with SIRIUS and BUDDY.
Assessment of Workers’ Perception of Occupational Hazards at Nampundwe Mine in Zambia
Authors: Phiri Anthony , Nyirenda Wezi , Phiri Enos , Phiri Maxwell , Muranda Andy , Mulenga Martha , Manchisi James 
Published: November 2024

ABSTRACTBackgroundThe extent to which Mineworkers perceive hazards at the workplace is important to avoid Mine accidents and thus prevent damage to health, life, and property. However, Mine accidents have increased despite the large investments in health and safety training programs.MethodsThe study used a mixed-method approach to collect data. The study comprised 205 Workers in total, consisting of 8 Managers, 18 Supervisors, 24 Machine Operators, 80 General Miners, and 75 Contractors. These respondents were chosen by using a purposive simplifying procedure. The study used semi-structured interviews, focus group discussions, and document reviews in the collection of data.ResultsStudy findings revealed that there was a significantly high impact of occupational health hazards on monthly income towards Contractors (p < 0.001, OR = 0.99, CI = 0.997-0.998). The study findings further reported that Workers at Nampundwe Mine have good to fair knowledge of occupational hazards. Supervisors appeared to have the highest level of awareness among the respondents, fair (38.97%), and good (54.61%). The Contractors had the lowest level of awareness and these were ranked as either fair (37, 05%) or good (18.65%).It has also revealed that the major causes of accidents are contravening of Safety Rules (38.11%) Falling from Heights (37.52%), Trackless Vehicles (8%), Rock Falling (5.4%), Morning Shifts (4.01%) and Electricity Shocks (6.91%)Further, the results reported that the major causes of accidents are falling from heights recorded a (37.52%) followed by trackless vehicles at (25.00%), rock falling standing at (16.06%), electricity shock (12.58%), explosion (7.10%), and least flooding at (1.74 %). Additionally, respondents are trained on how to respond to an emergency. And are very much aware of the health and safety measures and all standard operation procedures but rarely follow them when executing tasks.ConclusionsOur result found Workers have good to fair knowledge of occupational hazards. Supervisors appeared to have the highest level of awareness among the respondents.
Long-telomeropathy is associated with tumor predisposition syndrome
Authors: Allaire Patrick , Mayer John , Moat Luke , Gabor Rachel , Shay Jerry W. , He Jing , Zeng Chenjie , Bastarache Lisa , Hebbring Scott 
Published: November 2024

SummaryTelomeres protect chromosomal integrity, and telomere length (TL) is influenced by environmental and genetic factors. While short-telomeres are linked to rare telomeropathies, this study explored the hypothesis that a “long-telomeropathy” is associated with a cancer-predisposing syndrome. Using genomic and health data from 113,861 individuals, a trans-ancestry polygenic risk score for TL (PRSTL) was developed. A phenome-wide association study (PheWAS) identified 65 tumor traits linked to elevated PRSTL. Using this result, a trans-ancestry phenotype risk score for a long-TL (PheRSLTL) was develop and validated. Rare variant analyses revealed 13 genes associated with PheRSLTL. Individuals who were carriers of these rare variants had a predisposition for long-TL validating original hypothesis. Most of these genes were new to both cancer and telomere biology. In conclusion, this study identified a novel tumor-predisposing syndrome shaped by both common and rare genetic variants, broadening the understanding of telomeropathies to those with a predisposition for long telomeres.
Systematic Evaluation of Adiposity Indices as Predictors of Hypertension Risk in Children and Adolescents
Authors: Zhu Bowen , Zhan Shumin , Shi Hui , Wang Xingyun , Yue Jingwen , Gao Jianfang , Wang Tongshuai , Wang Rui , Guo Xirong , Fu Junfen 
Published: November 2024

AbstractObjectiveTo systemically examine the concomitant impact of adiposity indices on hypertension in children and adolescents.MethodsA community-based cohort study by China Health and Nutrition Survey (2009-2011) included 262 children and adolescents aged 7-17. Anthropometric and lipid profiles were analyzed for hypertension risk using logistic and cross-lagged models.ResultsOf the 227 participants (mean age, 16.5 [2.3] years), 147 (53.9%) were boys. Over a two-year period, 26.4% developed hypertension, 5.3% had elevated systolic blood pressure (SBP), and 25.6% had elevated diastolic blood pressure (DBP). After adjusting for covariates, higher body mass index (BMI), waist circumference (WC), hip circumference (HC), triceps skinfold thickness (TST), and body roundness index (BRI) were associated with increased hypertension risk. Incorporating these measures into a BP-based model improved the AUC for hypertension prediction from 0.551 (95% CI: 0.463, 0.640) to 0.670 (95% CI: 0.592, 0.748). A longitudinal relationship were observed between these adiposity indices and hypertension symptoms.ConclusionsThe study suggests anthropometry parameters are superior to blood lipid indicators in predicting the occurrence of hypertension in children. Abdominal obesity, as indicated by WC, HC, and BRI, accounts for a significant portion of the risk for hypertension, particularly in children aged 7 to 12 years.