bluuebunny/crossref_metadata_2025_split huggingface dataset:
An optimised gravitational wave follow-up strategy with the Australian Square Kilometre Array Pathfinder
Authors: Dobie D. , Murphy T. , Kaplan D. L. , Ghosh S. , Bannister K. W. , Hunstead R. W. 
Published: April 2019

AbstractThe detection of a neutron star merger by the Advanced Laser Interferometer Gravitational-Wave Observatory and Advanced Virgo gravitational wave detectors, and the subsequent detection of an electromagnetic counterpart have opened a new era of transient astronomy. With upgrades to the Advanced Laser Interferometer Gravitational-Wave Observatory and Advanced Virgo detectors and new detectors coming online in Japan and India, neutron star mergers will be detected at a higher rate in the future, starting with the O3 observing run which will begin in early 2019. The detection of electromagnetic emission from these mergers provides vital information about merger parameters and allows independent measurement of the Hubble constant. The Australian Square Kilometre Array Pathfinder is expected to become fully operational in early 2019, and its 30 deg2 field of view will enable us to rapidly survey large areas of sky. In this work we explore prospects for detecting both prompt and long-term radio emission from neutron star mergers with Australian Square Kilometre Array Pathfinder and determine an observing strategy that optimises the use of telescope time. We investigate different strategies to tile the sky with telescope pointings in order to detect radio counterparts with limited observing time, using 475 simulated gravitational wave events. Our results show a significant improvement in observing efficiency when compared with a naïve strategy of covering the entire localisation above some confidence threshold, even when achieving the same total probability covered.
From Jerusalem to the Rest of the West Bank: Israel's Strategies of Annexation
Authors: Shehadeh Raja 
Published: April 2019

AbstractSince 1967, despite international legal restrictions, Israel has sought to annex Eastern Jerusalem. Fifty-one years later, it publicly declared in its Nation State Law: “Jerusalem, complete and united, is the capital of Israel.” In the West Bank, Israel initiated on the ground changes that furthered annexation without formally declaring any part of it as annexed. For decades, Al-Haq has documented the gradual encroachment of occupation by successive Israeli administrations. And yet the Palestinian leadership failed to successfully utilize the law to support its case. Nor could the 190 states, parties to the Fourth Geneva Convention, be convinced to enforce the provision in the Convention which bids the High Contracting Parties to “ensure respect for the present convention in all circumstances.” During the Oslo negotiations, Israel succeeded in leaving Jerusalem and the Jewish settlements outside of the jurisdiction of the Palestinian Authority. Given these patterns across nearly a half-century of history, it seems likely that Israel will declare the full annexation of the West Bank in part or in its entirety precisely because it has succeeded in accomplishing this in the case of Jerusalem.
Outcomes and change processes of an established family education program for carers of adults diagnosed with a serious mental health condition
Authors: Farhall John , Cugnetto Marilyn L. , Mathews Stephanie , Ratcliff Kirk , Farnan Sue , Higgins Kate , Constantine Emma 
Published: April 2019

AbstractBackgroundFamily education programs (FEPs) target caregiving-related psychological distress for carers of relatives/friends diagnosed with serious mental health conditions. While FEPs are efficacious in reducing distress, the mechanisms are not fully known. Peer group support and greater mental health knowledge are proposed to reduce carers' psychological distress by reducing stigmatising attitudes and self-blame, and strengthening carers' relationship with their relative.MethodsAdult carers (n = 1016) who participated in Wellways Australia's FEP from 2009 to 2016 completed self-report questionnaires at the core program's start and end, during the consolidation period, and at a 6-month follow-up. Those who enrolled early completed questionnaires prior to a wait-list period. We used linear mixed-effects modelling to assess the program's effectiveness using a naturalistic wait-list control longitudinal design, and multivariate latent growth modelling to test a theory-based process change model.ResultsWhile there was no significant change over the wait-list period, psychological distress, self-blame and stigmatising attitudes significantly decreased, and communication and relationship quality/feelings increased from the core program's start to its end. Changes were maintained throughout the consolidation period and follow-up. Peer group support significantly predicted the declining trajectory of distress. Peer group support and greater knowledge significantly predicted declining levels of self-blame and stigmatising attitudes, and increasing levels of communication.ConclusionsThis is the first study to quantitatively validate the mechanisms underlying the effect of FEPs on carers' psychological distress. Peer group support is key in modifying carers' appraisals of their friend/relatives' condition. Continued implementation of FEPs within mental health service systems is warranted.
Infant language predicts fathers’ vocabulary in infant-directed speech
Authors: QUIGLEY Jean , NIXON Elizabeth 
Published: April 2019

AbstractResearch on sources of individual difference in parental Infant-Directed Speech (IDS) is limited and there is a particular lack of research on fathers’ compared to mothers’ speech. This study examined the predictive relations between infant characteristics and variability in paternal lexical diversity (LD) in dyadic free play with two-year-olds (M = 24.1 months, SD = 1.39, 35 girls). Ten minutes of interaction for sixty-four father–infant dyads were transcribed and multiple regression analyses were performed to examine the effects of a set of distal and proximal sources of infant influence on paternal LD. Fathers’ LD was predicted only by infant language, both standardised language scores and dynamic language measures, and was not predicted by infant age, gender, executive function, or temperament. Findings are discussed in the light of the complex interplay of factors contributing to variability in IDS and the infant's linguistic environment.
Evidence for functional GABAA but not GABAC receptors in mouse cone photoreceptors
Authors: Deniz Sercan , Wersinger Eric , Picaud Serge , Roux Michel J. 
Published: April 2019

AbstractAt the first retinal synapse, horizontal cells (HCs) contact both photoreceptor terminals and bipolar cell dendrites, modulating information transfer between these two cell types to enhance spatial contrast and mediate color opponency. The synaptic mechanisms through which these modulations occur are still debated. The initial hypothesis of a GABAergic feedback from HCs to cones has been challenged by pharmacological inconsistencies. Surround antagonism has been demonstrated to occur via a modulation of cone calcium channels through ephaptic signaling and pH changes in the synaptic cleft. GABAergic transmission between HCs and cones has been reported in some lower vertebrates, like the turtle and tiger salamander. In these reports, it was revealed that GABA is released from HCs through reverse transport and target GABA receptors are located at the cone terminals. In mammalian retinas, there is growing evidence that HCs can release GABA through conventional vesicular transmission, acting both on autaptic GABA receptors and on receptors expressed at the dendritic tips of the bipolar cells. The presence of GABA receptors on mammalian cone terminals remains equivocal. Here, we looked specifically for functional GABA receptors in mouse photoreceptors by recording in the whole-cell or amphotericin/gramicidin-perforated patch clamp configurations. Cones could be differentiated from rods through morphological criteria. Local GABA applications evoked a Cl− current in cones but not in rods. It was blocked by the GABAA receptor antagonist bicuculline methiodide and unaffected by the GABAC receptor antagonist TPMPA [(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid]. The voltage dependency of the current amplitude was as expected from a direct action of GABA on cone pedicles but not from an indirect modulation of cone currents following the activation of the GABA receptors of HCs. This supports a direct role of GABA released from HCs in the control of cone activity in the mouse retina.
Emotion dysregulation: A theme in search of definition
Authors: Thompson Ross A. 
Published: April 2019

AbstractEmotion dysregulation is defined as patterns of emotional experience or expression that interfere with goal-directed activity. This paper considers this functionalist definition from a developmental perspective with the goal of elaborating this approach with respect to its central questions. What are the goals that are impeded by emotionally dysregulated responding, and what alternative goals might motivate emotion dysregulation? What are the developmental processes by which these goals take shape, and what are the influences of the family context, and especially of central relationships in the family, in their emergence? How does this functionalist account address the complex interaction of experience and developing biological processes that also influence emotion regulation and dysregulation? Drawing on research literature concerning children at risk for affective psychopathology and considering relevant examples of the interaction of biology and context, this discussion offers a portrayal of emotion dysregulation as a biologically dynamic, experience-based aspect of adaptation to environments and relationships that, in conditions of risk for the emergence of developmental psychopathology, motivates patterns of emotional responding that serve immediate coping often at the cost of long-term maladaptation. Implications for emotions theory and the study of developmental psychopathology are also considered.
The full-reducing Krivine abstract machine KN simulates pure normal-order reduction in lockstep: A proof via corresponding calculus
Authors: GARCÍA-PÉREZ ÁLVARO , NOGUEIRA PABLO 
Published: April 2019

AbstractWe exploit the idea of proving properties of an abstract machine by using a corresponding semantic artefact better suited to their proof. The abstract machine is an improved version of Pierre Crégut’s full-reducing Krivine machine KN. The original version works with closed terms of the pure lambda calculus with de Bruijn indices. The improved version reduces in similar fashion but works on closures where terms may be open. The corresponding semantic artefact is a structural operational semantics of a calculus of closures whose reduction relation is purposely a reduction strategy. As shown in previous work, improved KN and the structural operational semantics ‘correspond’, i.e. both artefacts realise the same reduction strategy. In this paper, we prove in the calculus of closures that the reduction strategy simulates in lockstep (at every reduction step) the complete and standard normal-order strategy (i.e. leftmost reduction to normal form) of the pure lambda calculus. The simulation is witnessed by a substitution function from closures of the closure calculus to pure terms of the pure lambda calculus. Thus, KN also simulates normal-order in lockstep by the correspondence. This result is stronger than the known proof that KN is complete, for in the pure lambda calculus there are complete but non-standard strategies. The lockstep simulation proof consists of straightforward structural inductions, thanks to three properties of the closure calculus we call ‘index alignment’, ‘parameters-as-levels’ and ‘balanced derivations’. The first two come from KN. Thanks to these properties, a proof in a calculus of closures involving de Bruijn indices and de Bruijn levels is unproblematic. There is no lexical adjustment at binding lookup, on-the-fly alpha-conversion or recursive traversals of the term to deal with bound and free variables as in other calculi. This paper contributes to the framework for environment machines of Biernacka and Danvy a full-reducing open-terms closure calculus, its corresponding abstract machine, and a lockstep simulation proof via a substitution function.
Militarized masculinities beyond methodological nationalism: charting the multiple masculinities of an Indonesian jihadi
Authors: Duriesmith David , Ismail Noor Huda 
Published: April 2019

AbstractStudies of masculinity and armed conflict have struggled to capture the complex interaction between globalized militarized masculinities and local gender formations. Particularly in conflicts characterized by a high degree of combatant mobility (in the form of foreign fighters, massed displacement, or significant diaspora involvement) locating the relevant gender dynamics can prove to be a difficult step in understanding the character of armed groups. Based on fieldwork with Indonesian former foreign fighters, we make the case that feminist international relations have tended to unreflectively default to the nation when locating gender hierarchies. Exploring the multiple articulations of masculinity present in former fighters’ lives, we suggest that efforts must be made to resist methodological nationalism in understanding the relationship between gender hierarchies and armed conflict. Charting how foreign fighters traverse local constructions of gender, national gender hierarchies, and transnational social structures to participate in the conflict, we argue that adopting a conscious consideration of scale in our research method is needed to move beyond methodological nationalism.
Mobilizing transdisciplinary collaborations: collective reflections on decentering academia in knowledge production
Authors: Alonso-Yanez Gabriela , House-Peters Lily , Garcia-Cartagena Martin , Bonelli Sebastian , Lorenzo-Arana Ignacio , Ohira Marcella 
Published: April 2019

Non-technical summaryGlobal sustainability challenges and their impact on society have been well-documented in recent years, such as more intense extreme weather events, environmental degradation, as well as ecosystem and biodiversity loss. These challenges require a united effort of scientists from multiple disciplines with stakeholders, including government, non-government organizations, corporate industry, and members of the general public, with the aim to generate integrated knowledge with real-world applicability. Yet, there continues to be challenges for these types of collaboration. In this commentary, we describe processes of collective unlearning that serve to decenter academia in collaborations leading to a more equitable positioning of practitioners engaged in collaborative global sustainability research.
Pacific Anthropogenic Carbon Between 1991 and 2017
Authors: Carter B. R. , Feely R. A. , Wanninkhof R. , Kouketsu S. , Sonnerup R. E. , Pardo P. C. , Sabine C. L. , Johnson G. C. , Sloyan B. M. , Murata A. , Mecking S. , Tilbrook B. , Speer K. , Talley L. D. , Millero F. J. , Wijffels S. E. , Macdonald A. M. , Gruber N. , Bullister J. L. 
Published: April 2019

AbstractWe estimate anthropogenic carbon (Canth) accumulation rates in the Pacific Ocean between 1991 and 2017 from 14 hydrographic sections that have been occupied two to four times over the past few decades, with most sections having been recently measured as part of the Global Ocean Ship‐based Hydrographic Investigations Program. The rate of change of Canth is estimated using a new method that combines the extended multiple linear regression method with improvements to address the challenges of analyzing multiple occupations of sections spaced irregularly in time. The Canth accumulation rate over the top 1,500 m of the Pacific increased from 8.8 (±1.1, 1σ) Pg of carbon per decade between 1995 and 2005 to 11.7 (±1.1) PgC per decade between 2005 and 2015. For the entire Pacific, about half of this decadal increase in the accumulation rate is attributable to the increase in atmospheric CO2, while in the South Pacific subtropical gyre this fraction is closer to one fifth. This suggests a substantial enhancement of the accumulation of Canth in the South Pacific by circulation variability and implies that a meaningful portion of the reinvigoration of the global CO2 sink that occurred between ~2000 and ~2010 could be driven by enhanced ocean Canth uptake and advection into this gyre. Our assessment suggests that the accuracy of Canth accumulation rate reconstructions along survey lines is limited by the accuracy of the full suite of hydrographic data and that a continuation of repeated surveys is a critical component of future carbon cycle monitoring.
How Much of the Sediment in Gale Crater's Central Mound Was Fluvially Transported?
Authors: Thomson Bradley J. , Buczkowski Debra L. , Crumpler Larry S. , Seelos Kimberly D. , Fassett Caleb I. 
Published: April 2019

AbstractThe origin of the sedimentary mound within Gale crater, the landing site for the Mars Science Laboratory rover Curiosity, remains enigmatic. Here we examine the total potential contribution of fluvial material by conducting a volume‐based analysis. On the basis of these results, the mound can be divided into three zones: lower, intermediate, and upper zones. The top boundary of the lowermost zone is defined by maximal contribution of water‐lain sediments, which are ~13% to 20% of the total mound volume. The upper zone is defined by the elevation of the unbreached rim to the north (–2.46 km); sediments above this elevation cannot have been emplaced by flowing water. These volume balance calculations indicate that mechanisms other than flowing water are required to account for the overwhelming majority of the sediments transported into Gale crater. The most likely candidate process is settling from eolian suspension.
Retrieving Precipitable Water Vapor From Shipborne Multi‐GNSS Observations
Authors: Wang Jungang , Wu Zhilu , Semmling Maximilian , Zus Florian , Gerland Sebastian , Ramatschi Markus , Ge Maorong , Wickert Jens , Schuh Harald 
Published: April 2019

AbstractPrecipitable water vapor (PWV) is an important parameter for climate research and a crucial factor to achieve high accuracy in satellite geodesy and satellite altimetry. Currently Global Navigation Satellite System (GNSS) PWV retrieval using static Precise Point Positioning is limited to ground stations. We demonstrated the PWV retrieval using kinematic Precise Point Positioning method with shipborne GNSS observations during a 20‐day experiment in 2016 in Fram Strait, the region of the Arctic Ocean between Greenland and Svalbard. The shipborne GNSS PWV shows an agreement of ~1.1 mm with numerical weather model data and radiosonde observations, and a root‐mean‐square of ~1.7 mm compared to Satellite with ARgos and ALtiKa PWV. An improvement of 10% is demonstrated with the multi‐GNSS compared to the Global Positioning System solution. The PWV retrieval was conducted under different sea state from calm water up to gale. Such shipborne GNSS PWV has the promising potential to improve numerical weather forecasts and satellite altimetry.
USP10 modulates the SKP2/Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia
Authors: Liao Yuning , Liu Ningning , Xia Xiaohong , Guo Zhiqiang , Li Yanling , Jiang Lili , Zhou Ruiqing , Tang Daolin , Huang Hongbiao , Liu Jinbao 
Published: April 2019

AbstractConstitutive activation of tyrosine kinase Bcr-Abl is the leading cause of the development and progression of chronic myeloid leukemia (CML). Currently, the application of tyrosine kinase inhibitors (TKIs) targeting the Bcr-Abl is the primary therapy for CML patients. However, acquired resistance to TKIs that develops overtime in the long-term administration renders TKIs ineffective to patients with advanced CML. Therefore, increasing studies focus on the amplified expression or activation of Bcr-Abl which is proposed to contribute to the advanced phase. Here, we show that S-phase kinase-associated protein 2 (SKP2) acts as a co-regulator of Bcr-Abl by mediating its K63-linked ubiquitination and activation. Further investigations show that USP10 as a novel deubiquitinase of SKP2 amplifies the activation of Bcr-Abl via mediating deubiquitination and stabilization of SKP2 in CML cells. Moreover, inhibition of USP10 significantly suppresses the proliferation of both imatinib-sensitive and imatinib-resistant CML cells, which likely depends on SKP2 status. This findings are confirmed in primary CML cells because these cells are over-expressed with USP10 and SKP2 and are sensitive to a USP10 inhibitor. Taken together, the present study not only provides a novel insight into the amplified activation of Bcr-Abl in CML, but also demonstrates that targeting the USP10/SKP2/Bcr-Abl axis is a potential strategy to overcome imatinib resistance in CML patients.
Concomitant opening of a bulk-gap with an emerging possible Majorana zero mode
Authors: Grivnin Anna , Bor Ella , Heiblum Moty , Oreg Yuval , Shtrikman Hadas 
Published: April 2019

AbstractMajorana quasiparticles are generally detected in a 1D topological superconductor by tunneling electrons into its edge, with an emergent zero-bias conductance peak (ZBCP). However, such a ZBCP can also result from other mechanisms, hence, additional verifications are required. Since the emergence of a Majorana must be accompanied by an opening of a topological gap in the bulk, two simultaneous measurements are performed: one in the bulk and another at the edge of a 1D InAs nanowire coated with epitaxial aluminum. Only under certain experimental parameters, a closing of the superconducting bulk-gap that is followed by its reopening, appears simultaneously with a ZBCP at the edge. Such events suggest the occurrence of a topologically non-trivial phase. Yet, we also find that ZBCPs are observed under different tuning parameters without simultaneous reopening of a bulk-gap. This demonstrates the importance of simultaneous probing of bulk and edge in the identification of Majorana edge-states.
Age- and sex-specific prevalence of chronic comorbidity in adult patients with asthma: A real-life study
Authors: Veenendaal Mathijs , Westerik Janine A. M. , van den Bemt Lisette , Kocks Janwillem W. H. , Bischoff Erik W. , Schermer Tjard R. 
Published: April 2019

AbstractThe presence of comorbidity can be associated with poorer asthma outcomes. Previous prevalence studies focused on a limited selection of comorbid conditions in asthma only. We aimed to determine age- and sex-specific prevalence estimates for the full range of chronic comorbid conditions in adult asthma patients by performing a retrospective cohort study based on 32,787 medical records of patients aged ≥16 years with asthma from 179 general practices in the Netherlands. Age- and sex-specific prevalence estimates of 76 chronic comorbidities and 14 disease categories based on International Classification of Primary Care codes were determined. Chronic comorbidity was present in 65.3% of male asthma patients and 72.8% of female asthma patients, with female patients having a higher mean (SD) of 2.0 (2.1) comorbidities compared to male patients (1.7 (2.0)). This mean increased to 5.0 (2.7) conditions in the 75+ age group. Most prevalent comorbidities were hypertension (20.1%), osteoarthritis (11.5%), eczema (11.5%) and dyspepsia (10.7%). Compared to male asthma patients, female asthma patients showed higher odds for the presence of other chronic conditions in eight disease categories. Neurological (odds ratio [OR]; 95% confidence interval 2.01; 1.76–2.29), blood forming/lymphatics (OR 1.83; 1.38–2.42) and musculoskeletal diseases (OR 1.82; 1.69–1.95) showed the highest association with female sex. In conclusion, the presence of chronic comorbidity is the norm in adults with asthma and it is more prevalent in female than in male asthma patients. The odds of having a specific comorbid condition may differ between the sexes. Attention in guidelines on how to handle comorbidities may lead to a more targeted treatment for comorbidities and more patient-centred asthma management.