bluuebunny/crossref_metadata_2025_split huggingface dataset:
International Shocks, Variable Markups, and Domestic Prices
Authors: Amiti Mary , Itskhoki Oleg , Konings Jozef 
Published: January 2019

Abstract
How strong are strategic complementarities in price setting across firms? In this article, we provide a direct empirical estimate of firms’ price responses to changes in competitor prices. We develop a general theoretical framework and an empirical identification strategy, taking advantage of a new micro-level dataset for the Belgian manufacturing sector. We find strong evidence of strategic complementarities, with a typical firm adjusting its price with an elasticity of 0.4 in response to its competitors’ price changes and with an elasticity of 0.6 in response to its own cost shocks. Furthermore, we find evidence of substantial heterogeneity in these elasticities across firms. Small firms exhibit no strategic complementarities in price setting and complete cost pass-through. In contrast, large firms exhibit strong strategic complementarities, responding to both competitor price changes and their own cost shocks with roughly equal elasticities of around 0.5. We show that this pattern of heterogeneity in markup variability across firms is important for explaining the aggregate markup response to international shocks and the observed low exchange rate pass-through into domestic prices.
The Family in Minimum Income Benefits in Europe: An Institutional Analysis
Authors: Frericks Patricia , Och Ralf , Höppner Julia 
Published: January 2019

AbstractWhether and to what extent the means of family members and familial care activities are relevant in the calculation of welfare benefits is often neglected in welfare state analysis. By quantifying qualitative institutional data, we analyze this aspect and how it has changed in regard to minimum-income benefits for persons of pension age and unemployed persons in ten European welfare states. We find no general trend toward individualization of entitlements but a decreasing relevance of family for the entitlements of persons of pension age, and increasing relevance for the unemployed. The evidence underlines significant differences between countries and family-related dimensions.
Factors affecting urinary creatinine in heifers and cows1
Authors: Whittet Kimberly M , Watson Andrea K , Erickson Galen E , Klopfenstein Terry J 
Published: January 2019

AbstractA series of total urine collections were conducted to evaluate the effects of age, diet, gestation, and body condition score (BCS) on urinary creatinine (UC) and purine derivative (PD) excretion in heifers and cows. For each collection, urine was collected over a 5-d period and composited by animal within day. Daily samples were analyzed for UC and PD concentration and averaged over the 5-d period. All animals were fed in individual stanchions at 2.0% of body weight (BW). To evaluate the relationship between age and UC excretion, 21 animals ranging from 5 to 80 months of age were fed a forage-based diet supplemented with dried distillers grains (DDG). Creatinine excretion (mg/kg BW) was not correlated with age (P = 0.37). To determine if diet alters UC, 11 heifers were sampled for two urine collection periods. In period 1, heifers were fed a forage-based diet supplemented with DDG. In period 2, heifers were fed a finishing diet (90% concentrate, 10% forage). Creatinine excretion (mg/kg BW) and PD:creatinine (PD:C) was greater (P = 0.01) for heifers when fed the forage-based diet than when fed the concentrate-based diet. Eleven cows fed a forage-based diet supplemented with DDG were sampled to determine the effect of gestation on urinary metabolites. Gestation did not affect UC (P = 0.42) or PD:C (P = 0.30). To evaluate the relationship between 12th rib fat thickness and metabolite excretion, 40 heifers were fed a common finishing diet. There was no relationship between UC (mg/kg BW; P = 0.28) or PD:UC (P = 0.47) and 12th rib fat thickness. To evaluate the relationship between BCS and UC, 11 cows were fed a forage diet supplemented with DDG. There was no relationship between BCS and UC (mg/kg BW; P = 0.99) or PD:C (P = 0.84). To evaluate daily and diurnal variation in UC, nine heifers were fed a forage diet supplemented with DDG. Seven of the heifers were fed a finishing diet (90% concentrate, 10% forage) in a second period. Urine was collected every 2 h from 0600 to 1800 hours. When expressed as mg/kg BW, UC excretion was not different across animals fed the forage-based (P = 0.40) or concentrate-based diet (P = 0.18). Stepwise regression indicated that at least 3 d of collection were required to estimate UC. Time within day and day within period effects were observed (P &lt; 0.01) for UC from 2-h interval samples. The UC varies with type of diet and diurnal variation is present. Variation among animals is relatively small.
A new continent in the geographic distribution of the genus Oregoniplana (Platyhelminthes: Tricladida: Maricola), its rediscovery in South Africa and its molecular phylogenetic position
Authors: Li Wei-Xuan , Sluys Ronald , Vila-Farré Miquel , Chen Jia-Jia , Yang Ying , Li Shuang-Fei , Wang An-Tai 
Published: January 2019

Abstract
Here we describe a new species for the genus Oregoniplana from the coast of China, representing the third species for the genus and the first record of this genus for Asia. The other species are known from Oregon, USA, and from South Africa. Specimens of the South African species, Oregoniplana pantherina, were recently rediscovered, forming the second record for the species, which provided the basis for a necessary re-description. Molecular data (18S rDNA and 28S rDNA) obtained for the new Chinese species facilitated determination of the position of the genus Oregoniplana in the phylogenetic tree of the marine triclads. We report molecular data also for species previously discovered in China, viz. Miroplana shenzhensis and Pentacoelum sinensis, thus enabling us to determine for the first time the phylogenetic position of the genus Miroplana. These new molecular data revealed that Pentacoleum sinensis occupies an unexpected position in the phylogenetic tree. Laboratory cultures of the new Chinese species provided information on food preferences and reproduction. Oregoniplana pantherina exhibits a peculiar kind of locomotion and an unusual resting position in which the animal has three points of contact on either side.
Preservation versus non-preservation of left colic artery in colorectal cancer surgery
Authors: Yang Xuyang , Ma Pingfan , Zhang Xubing , Wei Mingtian , He Yazhou , Gu Chaoyang , Deng Xiangbing , Wang Ziqiang 
Published: January 2019

Abstract

Background:
It remains unclear whether or not preservation of the left colic artery (LCA) for colorectal cancer surgery. The objective of this updated systematic review and meta-analysis is to evaluate the current scientific evidence of LCA non-preservation versus LCA preservation in colorectal cancer surgery.

Methods:
A systematic search was conducted in the Medline, Embase, PubMed, Cochrane Library, ClinicalTrials, Web of Science, China National Knowledge Infrastructure and Chinese BioMedical Literature Database, and reference without limits. Quality of studies was evaluated by using the Newcastle–Ottawa scale and the Cochrane Collaboration's tool for assessing the risk of bias. Effective sizes were pooled under a random- or fixed-effects model. The funnel plot was used to assess the publication bias. The outcomes of interest were oncologic consideration including the number of apical lymph nodes, overall recurrence, 5-years overall survival, and 5-years disease-free survival (DFS); safety consideration including overall 30-day postoperative morbidity and overall 30-day postoperative mortality; anatomic consideration including anastomotic circulation, anastomotic leakage, urogenital, and defaecatory dysfunction.

Results:
Twenty-four studies including 4 randomized controlled trials (RCTs) and 20 cohort studies with a total of 8456 patients (4058 patients underwent LCA non-preservation surgery vs 4398 patients underwent LCA preservation surgery) were enrolled in this meta-analysis. The preservation of LCA was associated with significantly less anastomotic leakage (odds ratio 1.23, 95% confidence interval 1.02–1.48, P = .03). In term of sexual dysfunction, urinary retention, the number of apical lymph nodes, and long-term oncologic outcomes, there were no significant differences between the LCA non-preservation and LCA preservation group. It was hard to draw definitive conclusions on other outcomes including operation time, blood loss, the first postoperative exhaust time, and perioperative morbidity and mortality for insufficient data and highly significant heterogeneity among studies.

Conclusions:
The pooled data provided evidence to support the LCA preservation preferred over LCA non-preservation in anastomotic leakage. Future more large-volume, well-designed RCTs with extensive follow-up are needed to draw a definitive conclusion on this dilemma.
Extensive small bowel metastasis and peritoneal dissemination 1 year following curative gastrectomy for T1N1 gastric cancer
Authors: Fan Shengxian , Feng Min , Wang Meng , Guan Wenxian 
Published: January 2019

Abstract

Rationale:
Metastasis of T1N1 gastric cancer (GC) at early stage after curative gastrectomy is unusual. Reports on the diagnosis, treatment, and prognosis of peritoneal metastasis following curative gastrectomy for T1N1 GC are lacking.

Patient concerns:
A 54-year-old woman was admitted to our hospital with complaints of mild abdominal distension and failure to pass gas and stool for 2 days. She has a history of distal gastrectomy for T1N1 GC. About 1 year after surgery, she presented with persistent abdominal distension and underwent conservative managements.

Diagnoses:
Imaging tests failed to identify the apparent cause of intestinal obstruction. When conservative managements failed to relieve the symptoms, she underwent emergency laparotomy, which revealed extensive small bowel metastasis and peritoneal dissemination.

Interventions:
Peritoneal irrigation and drainage were performed with the consent of the patient's families.

Outcomes:
The patient abandoned further therapy and died 1 week later during the follow-up period.

Lessons:
Although the metastasis of T1N1 GC is rare, patients with high risk of metastasis after curative surgery should also be closely followed and be considered as candidates for more aggressive screening strategies. In addition, the use of more effective chemotherapeutic drugs as adjuvant chemotherapy after curative surgery in T1N1 patients may also need to be explored.
Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma
Authors: Ouyang Zhuo , Chen Minxiu , Sun Jinping , Zhai Jianjun 
Published: January 2019

Abstract
To explore the role of hScrib in the pathogenesis of endometriosis.
This was a retrospective study of 240 women in our hospital between January 2014 and January 2017. The expression of hScrib in endometrium (EM), endometriosis (EMs), and endometrial adenocarcinoma (EC) was investigated, and compared the differences among them. Serum levels, protein expressions, localizations, and correlations of hScrib and E-cadherin were determined.
The levels of serum soluble hScrib and E-cadherin were significantly highest in EC, followed by EMs, and healthy women (P < .05). hScrib protein content was opposite result in 3 tissues (P < .05), and was negatively correlated with r-AFS stage in EMs. The location changed from membrane to cytoplasm. Co-localization of hScrib with E-cadherin was found at extensive cell–cell boundaries in EMs.
hScrib and E-cadherin may be as new diagnostic markers of endometriosis. Low expression of hScrib leads to the loss of cell polarity and stability. Also, hScrib may induce EMT through regulating E-cadherin, might play an important role in pathogenesis of endometriosis.
Horseshoe appendix identified during laparoscopic appendectomy
Authors: Choi Sang-Ji , Chae Gibong , Park Sung-Bae , Hong Seong Kweon , Kim Yang Hee , Moon Suk-Bae , Kim Song-Yi , Kim Hwansoo 
Published: January 2019

Abstract

Rationale:
The horseshoe anomaly of the vermiform appendix is extremely rare. Preoperative confirmation of this anomaly is difficult; therefore, routine procedures, such as appendectomy, may become unexpectedly challenging when such anomalies are encountered during the surgical process.

Patient concerns:
A 33-year-old man presented with abdominal pain in the right lower abdomen owing to acute appendicitis confirmed via computed tomography. Immediate laparoscopic appendectomy was decided as the method for treatment.

Diagnosis:
Horseshoe anomaly was diagnosed as a gross finding during surgery.

Intervention:
First, the appendiceal base was resected and appendectomy was performed via the retrograde method because the appendiceal tip was curled behind the cecum. However, it was discovered that the appendiceal tip was connected to the lateral part of the ascending colon and showed a horseshoe-shaped anomaly. The second appendiceal base arising from the ascending colon was also ligated, and the appendectomy was completed without any further complications.

Outcomes:
After successful completion of appendectomy, the patient was discharged without any complications 2 days later.

Lessons:
An appendiceal anomaly is rarely seen during appendectomy or other forms of abdominal surgery; however, the ability of surgeons to both recognize and categorize an appendiceal anomaly is crucial if detected during surgery. After successfully recognizing the horseshoe anomaly of the appendix, it is important to know that 2 appendiceal base ligations will be required to complete the surgery successfully.
Distinguishing tuberculosis pleural effusion from parasitic pleural effusion using pleural fluid characteristics
Authors: Tong Shuai , Zhu Yu , Wan Chaomin 
Published: January 2019

Abstract
Tuberculosis pleural effusion (TPE) and parasitic pleural effusion (PPE) present with similar clinical manifestations. We evaluated the pleural fluid features of TPE and PPE.
A total of 76 patients with pleuritis, including 25 patients with TPE and 51 patients with PPE were retrospectively studied. Pleural fluid was sent for analyses of protein, cytology, cell count, acid fast bacilli (AFB) staining, Gram stain, culture, sensitivity, and adenosine dehydrogenase (ADA).
The proportion of eosinophilia present in the PPE group was significantly higher than that in the TPE group (P < .001). However, the proportion of lymphocytes found in the TPE group was significantly higher than that in the PPE group (P < .001). The mean level (SD) of ADA was 46.99 ± 22.09 U/L in the TPE group and 39.08 ± 23.03 U/L in the PPE group. No difference was detected between the study groups in terms of the ADA level of the pleural fluid (P > .05).
When the results of pleural fluid testing reveal marked eosinophilia and a low proportion of lymphocytes, physicians should consider a diagnosis of PPE, especially for patients who live in or have traveled to endemic areas.
Sedation for terminally ill cancer patients
Authors: Kim Young Saing , Song Haa-Na , Ahn Jin Seok , Koh Su-Jin , Ji Jun Ho , Hwang In Gyu , Yun Jina , Kwon Jung Hye , Kang Jung Hun 
Published: January 2019

Abstract
Sedation therapy is a potential solution to providing relief from refractory symptoms at end of life. The aim of this study was to investigate actual sedation practice and physician characteristics associated with the use of sedation for terminally ill cancer patients in South Korea.
A retrospective review was conducted on consecutive patients who had died from cancer at seven tertiary medical centers between January 2010 and October 2015. The use of sedation was defined as the administration of sedative agents to relieve intolerable symptoms within the last 2 weeks preceding death. Patients and physician characteristics and information on the use of sedation were collected.
A total of 8309 patients were included in the study. Sedatives were administered in 1334 patients (16.1%) for the following indications: delirium in 39.3%, intractable pain in 23.1%, and dyspnea in 21.9%. Median duration of sedation from initiation to death was 3 days. The use of sedation depended on physician specialty and experience. Family physicians used sedation most often (57.6%), followed by medical oncologists (13.9%), other internists (10.7%), and surgical oncologists (9.4%). The use of sedation was highest for physicians with >5 to 10 years practice experience (22.1%) and lowest for those in practice for 5 years or less (10.2%). The proportion of patients receiving sedation also varied markedly across participating institutions (range, 7.0%–49.7%).
This large cohort study provides insight into sedation practice for terminally ill cancer patients in South Korea. Our study shows that the use of sedation depends on physician background and institution. A nation-wide guidelines and continued education on end-of-life sedation are required in South Korea.
Comparing the effectiveness of three scoring systems in predicting adult patient outcomes in the emergency department
Authors: Wei Xiaojun , Ma Haoli , Liu Ruining , Zhao Yan 
Published: January 2019

Abstract
This study aimed to evaluate the performance of the rapid acute physiology score (RAPS), the rapid emergency medicine score (REMS), and the modified early warning score (MEWS) in predicting the outcomes of adult patients presenting to the emergency department (ED).
A retrospective review was undertaken between February 2014 and February 2018 in an adult ED of a 3300-bed university hospital. The RAPS, REMS, and MEWS were calculated to assess their capability to predict hospital admission, length of hospital stay, and in-hospital mortality, using area under receiver operating characteristic analysis. Multivariate analysis was used to identify variables that were independent predictors of the outcomes.
We included 39,977 patients who had presented to the ED during 48 consecutive months, of whom 4857 were admitted and 213 died in hospital. The predictabilities of REMS, RAPS, and MEWS for hospital admission were 0.76, 0.59, and 0.55, respectively; the predictability of REMS, RAPS, and MEWS for hospital mortality were 0.88, 0.72, and 0.73, respectively; and the predictability of REMS, RAPS, and MEWS for length of hospital stay were 0.76, 0.67, and 0.65, respectively. Multivariate analysis showed that the Glasgow coma scale (GCS) (odds ratio (OR), 1.61; P < .001), age (OR, 1.50; P < .001), and MAP (OR, 1.27; P < .001) were independent predictors for hospital admission; GCS (OR, 2.92; P < .001), respiratory rate (RR) (OR, 2.69; P < .001), peripheral oxygen saturation (OR, 2.67; P < .001), MAP (OR, 2.11; P < .001), age (OR, 1.75; P < .001), and pulse rate (PR) (OR, 1.73; P < .001) were independent predictors for in-hospital mortality; and RR (OR, 1.41; P < .001), temperature (OR, 1.05; P = .01), and PR (OR, 0.96; P = .04) were independent predictors for length of hospital stay.
Our study evaluated and confirmed the REMS as a powerful predictor of ED adult patient outcomes, including hospital admission, length of hospital stay, and in-hospital mortality compared to RAPS and MEWS.
Large deformity correction in medial open-wedge high tibial osteotomy may cause degeneration of patellofemoral cartilage
Authors: Otakara Eigo , Nakagawa Shuji , Arai Yuji , Inoue Hiroaki , Kan Hiroyuki , Nakayama Yusuke , Fujii Yuta , Ueshima Keiichiro , Ikoma Kazuya , Fujiwara Hiroyoshi , Kubo Toshikazu 
Published: January 2019

Abstract
To evaluate retrospectively any association between the degree of deformity correction by medial open-wedge high tibial osteotomy (HTO) and patellofemoral joint degeneration. We hypothesized that development of patellofemoral joint degeneration depended on the degree of intraoperative deformity correction.
Fifty-seven patients who underwent medial open-wedge HTO for treatment of osteoarthritis in one knee were included in this study. Knees were classified into degeneration (D) and non-degeneration (ND) groups according to worsening of the patellar and/or femoral trochlear cartilage at the time of hardware removal (D group, 27 knees) and no degeneration or improvement (ND group, 30 knees). We compared pre- to post-surgery change in hip-knee-ankle angle (HKA) and medial-proximal-tibial angle (MPTA), open-wedge HTO correction angle, and arthroscopic findings between groups.
Mean age, height, weight, and body mass index were 54.1 ± 9.9 years, 160.4 ± 8.7 cm, 66.4 ± 12.1 kg, and 25.7 ± 3.3 kg/m2, respectively. Change in both HKA and MPTA differed significantly between groups. The MPTA cut-off values to predict patellofemoral degeneration were determined to be 10°, associated with an AUC of 0.75 (95% confidence interval [CI] 0.62–0.87).
This study evaluated retrospectively the effect of the correction angle during medial open-wedge HTO on patellofemoral joint degeneration. If deformity correction exceeds an MPTA of 10° during open-wedge HTO, degeneration of patellofemoral joint needs to be considered.
Level of evidence: Level IV.
The related factors for the recovery and maintenance time of sinus rhythm in hospitalized patients with cardiopulmonary resuscitation
Authors: Lv Jun Hua , Wang Dan , Zhang Meng Na , Bai Zheng Hai , Sun Jiang-Li , Shi Yu , Pei Hong Hong , Zhang Zheng-Liang , Wang Hai 
Published: January 2019

Abstract
No matter in or outside hospital, the success rate of cardiopulmonary resuscitation (CPR) is very low. The sign of successful CPR is the recovery of spontaneous circulation. The premise of the recovery of spontaneous circulation is the recovery and maintenance of sinus rhythm, but there is still no related research.
We aim to study the factors for the recovery and maintenance time of sinus rhythm in patients with CPR.
A single-center retrospective case–control study.
Ethical review was obtained (ethical approval number: 20180031).
The second affiliated hospital of Xi’an Jiaotong University, Xi’an Shaanxi, China.
From January 2011 to December 2016, totally 344 cases met the inclusion and exclusion criteria, sinus rhythm recovered group (SR group) (n = 130 cases), sinus rhythm unrecovered group (SUR group) (n = 214 cases).
The multivariate logistic regression analysis showed that red blood cell counts (OR = 1.30, 95% CI:1.04–1.63, P = .02), rescue time (OR = 0.95, 95% CI:0.94–0.97, P <.001), the usage of norepinephrine (OR = 2.14, 95% CI:1.06–4.35, P = .04) were important factor for the recovery of sinus rhythm in patients with CPR. Multivariate linear regression analysis showed that the dosage of epinephrine, the usage of naloxone and diagnosis were important factors for maintenance time of sinus rhythm after resuscitation, P <.05. The rescue time had high accuracy to predict the recovery of sinus rhythm, the area under the receiver operator characteristic (ROC) curve (AUC) was 0.84 (0.80, 0.88), sensitivity and specificity are respectively 71.54% and 93.46%.
Red blood cell counts, the rescue time and the usage of norepinephrine might be important factors for the recovery of sinus rhythm, and the dosage of epinephrine, the usage of naloxone and the diagnosis might be important factors for the maintenance time of sinus rhythm in patients with CPR.