bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ergonomics for children: An educational program for elementary	school
Authors: Heyman E. , Dekel H. 
Published: December 2024

Studies indicate that musculoskeletal discomfort and back pain problems are evident not only in adults, but also in children [11,13]. We believe that educating towards a balanced-posture, body-function and movement patterns, as well as their ergonomic implications, can minimize and even prevent these problems. Such an ergonomics awareness educational program has to start at childhood and should be an integral part of the curriculum in the schools. This article presents the educational program "Ergonomics, Movement and Posture" (EMP), which is taught in elementary schools by Physical Education (PE) students of the Kibbutzim College of Education in Israel, as part of their practicum. Although there has been no formal evaluation of the effectiveness of the program, so far, participating children, their parents, the teachers and the principles have offered positive feedback.
Occupational rehabilitation services provided by a community	workers health centre in Hong Kong: A case study
Authors: Chan Elaine Y.L. , Woo Karen W.S. , Tang Tina M.Y. 
Published: December 2024

Background: In Hong Kong, the Employees' Compensation Ordinance (ECO), based on the model of the English Workmen's Compensation Act 1943, establishes a no-fault, non-contributory system for work injuries. It focuses merely on the minimum social expectation in compensating injured workers in monetary terms, but does not place much emphasis on prevention, rehabilitation and return to work polices for workers with injury. There is a need to reform an effective and comprehensive occupational rehabilitation system for workers with work injury in Hong Kong. Methods: This paper presents a case study of a worker with work injury undergoing occupational rehabilitation through services provided in the local community setting by the Hong Kong Workers' Health Centre. Results: The case study highlights some crucial factors and/or intervention modalities in facilitating workers' return to work, including timely intervention, work-site based rehabilitation, communication among different stakeholders, dynamics of company, rehabilitation counselling, community integration and individualized work resettlement. Conclusion: Without reviewing and revamping the current ECO, the goal to provide timely and effective occupational rehabilitation services for workers with injury could not be fully achieved.
A study of the effectiveness of ergonomically-based functional	screening tests and their relationship to reducing worker compensation	injuries
Authors: Anderson Charles , Briggs Jim 
Published: December 2024

Objectives: This paper summarizes a series of studies of the effectiveness of ergonomically based functional screening tests for post offer pre-placement of applicants for physically demanding jobs, and their relationship to reducing worker compensation injuries. Three predictive validation studies and a meta-analysis of injury rates pre- and post-implementation of physical ability testing at 175 locations are included. Methods: The strength and energy expenditure demands of physically-strenuous warehouse jobs in three industries were documented through ergonomic analysis. A battery of strength and endurance tests were developed to assess applicants' abilities to meet the measured physical demands. Predictive validation studies were performed for the jobs in each of the three industries. In each study, new-hires were given the physical ability test battery and then placed on the job. Management was not informed of the results of the tests. Injury experience and work history were then monitored over a two year period in each study. Injury rates and retention were then compared for individuals who passed and individuals who failed the battery. As the battery was implemented in other locations, the injury rate for individuals starting employment in the year prior to implementation was compared to the injury rate for individuals starting employment in the year after implementation. Conclusions: A meta-analysis of the three predictive validation studies indicated that new-hires who passed the battery had a 47% lower worker compensation injury rate and 21% higher retention. A meta-analysis of the 175 pre/post-implementation studies indicated a 41% reduction in worker compensation injuries associated with implementation of ergonomically based physical ability tests.
Feasibility of using the EFPT to detect executive function	deficits at the acute stage of stroke
Authors: Wolf Timothy J. , Stift Stefanie , Connor Lisa Tabor , Baum Carolyn , The Cognitive Rehabilitation Research Group  
Published: December 2024

Objective: The goal of this study was to test the feasibility of administering subtests of the EFPT to stroke survivors in the acute phase of stroke to detect executive function deficits. Participants: A population of adults with mild to moderate stroke (N=20). Methods: This study employed a cross-sectional design using the EFPT and a neuropsychological battery immediately post-stroke. Results: Overall EFPT performance significantly correlated with 3 of the 13 DKEFS scaled scores: Sorting (r=−0.511, p=0.030), Verbal Fluency (r= −0.474, p=0.035) and Color-Word Interference (r= −0.566, p=0.011) and the Short Blessed Test (r = 0.548, p=0.012). Multiple significant correlations were also found between EFPT-bill paying and cooking subtests and DKEFS subtests. Conclusions: Performance on the EFPT one-week post stroke was very similar to what was found in a prior study validating the EFPT in stroke survivors at 6-months post-onset. The results of this study provide evidence to the support conducting a follow-up study in the acute care setting using the bill paying subtest of the EFPT along with a neuropsychological battery, to augment discharge planning.
Generating linked data in the model of RNPLS&T Single Open Information Archive (SOIA) using GEMET multilingual thesaurus
Authors: Goncharov M. V. , Kolosov K. A. 
Published: December 2024

The practical use of linked data in library projects implies their representation in the RDF format for further use and processing in information systems, and, on the other hand, enrichment of information delivered to the search portal users. In this study, the authors examine the aspects of information enrichment for search outcome. They used GEMET multilingual thesaurus as the basic data set for linking. The RNPLS&T Single Open Information Archive (SOIA) portal has been built based on advanced technologies and trends in using linked data. These trends are also reviewed. Despite plenty of data sets available via the Linked Open Data Cloud, the library projects embracing the linked data technology use just few overlapping data sets.To build the links between UDC codes and subject headings with GEMET concepts, the authors analyzed the entries in the e-catalogs of SOIA and “Ecology: Science and Technology” database. The analysis results demonstrate that approximately 20% entries comprise subject headings and UDC codes that might be linked to GEMET thesaurus concepts.The links between GEMET concepts and Internet-based DBpedia are seen as the most promising option. The authors suggest to supplement these links with the references to Ruwiki (Russian online encyclopedia). These additional links were established for UDC upper levels in the operational database and will be further created for every GEMET active concept.
The review of advanced methods and techniques for estimating research output in bibliometrics. (Part 2)
Authors: Zemskov A. I. , Telitsyna A. Y. 
Published: December 2024

The authors explore the significant changes in traditional bibliometrics, including distinctive innovations in this area. Advancement of e-publications and increasing role of open access systems are among the most significant developments. New approaches to providing access to feed scientific data are discussed. The governmental agencies has been increasingly encouraging the publication activity assessment, as well as design and development of the analogous national platforms, e.g. Russian Science Citation Index, eLIBRARY, and NEL. The sanctions prohibiting using Clarivate Analytics and Elsevier systems and products dictate the need for timely provision of comparative measurements with simultaneous application of national and global systems.The authors review in brief the improvements of existing methods, e.g. the introduction of the system of beamplot diagrams and research-based citation analysis. The role of scientometrics in global rankings is evaluated. The focus is also made on the new vectors of analysis, such as altmetrics and artificial intelligence. The application of artificial intelligence tools lays the basis for the entirely new system for comparing scientific publications with the existing array of accumulated knowledge.
Red flags for potential serious pathologies in people with neck pain: a systematic review of clinical practice guidelines
Authors: Feller Daniel , Chiarotto Alessandro , Koes Bart , Maselli Filippo , Mourad Firas 
Published: December 2024

Introduction: We conducted a systematic review of clinical practice guidelines to identify red flags for serious pathologies in neck pain mentioned in clinical practice guidelines, to evaluate agreement in red flag recommendations across guidelines, and to investigate the level of evidence including what study type the recommendations are based on.
Methods: We searched for guidelines focusing on specific and nonspecific neck pain in MEDLINE, EMBASE, and PEDro up to June 9, 2023. Additionally, we searched for guidelines through citation tracking strategies, by consulting experts in the field, and by checking guideline organization databases.
Results: We included 29 guidelines, 12 of which provided a total of 114 red flags for fracture (n = 17), cancer (n = 21), spinal infection (n = 14), myelopathy (n = 15), injury to the spinal cord (n = 1), artery dissection (n = 7), intracranial pathology (n = 3), inflammatory arthritis (n = 2), other systemic disease (n = 6), or unrelated to a specific condition (n = 19). Overall, there is very little agreement (median Fleiss’ kappa of 0) between guidelines on the red flags to screen for serious pathologies.
Conclusion: Red flags were mainly supported by expert opinions. We also observed a general lack of consensus among guidelines regarding which red flags to endorse. Considering the current limitations of the evidence, specific recommendations on which red flags to use cannot be provided, except for using the Canadian C-Spine rule for screening posttraumatic fractures.
Fludioxonil, Fenhexamid and Boscalid-Insensitive Botrytis Fabae Isolates Collected from Moroccan Faba Bean Fields
Authors: Aouzal Sarra , Zelmat Lamyaa , Houmairi Hafsa , Mentag Rachid , Krimi Bencheqroun Sanae 
Published: December 2024

Chocolate spot, caused by Botrytis fabae, poses a significant threat to faba bean production in Morocco, leading to decreased crop quality and quantity. This study assesses the sensitivity of B. fabae isolates to three fungicides-fenhexamid, fludioxonil, and boscalid-commonly used in Moroccan faba bean cultivation. Fungicide sensitivity tests were conducted on 22 single-spore isolates of B. fabae from five faba bean-growing regions in Morocco. The Growth Inhibition Percentage (GIP) of each isolate was calculated using an automated quantitative (AQ) test to determine sensitivity profiles to the three fungicides. Six representative isolates from different sensitivity profiles were tested against a range of concentrations of fenhexamid, fludioxonil, and boscalid (0–1,000 mg/L) to determine EC50 values. In vivo greenhouse experiment evaluated the efficacy of two fungicides fludioxonil and boscalid against B. fabae isolates with distinct sensitivity profiles. Mass Disease Index (MDI) was used to evaluate fungicide effectiveness. Results indicated that 45% of the isolates demonstrated resistance to fludioxonil, and 14% exhibited resistance to boscalid. Two of the three boscalid-resistant isolates were also resistant to fludioxonil. In contrast, the majority (95%) of isolates were moderately resistant or sensitive to fenhexamid. The calculated EC50 values of fludioxonil, boscalid and fenhexamid against B. fabae isolates clearly distinguished sensitive from resistant isolates; for resistant isolates EC50 were ≥ 140 mg/L while the values for sensitive isolates were ≤ 30 mg/L. In vivo trials revealed inefficacy of fludioxonil and boscalid against resistant isolates. These findings highlight the emergence of fludioxonil and boscalid insensitivity in B. fabae in Morocco, indicating the need for continuous monitoring of fungicide resistance in chocolate spot management. Future research should develop methods to manage fungicide resistance, aiming for sustainable control of chocolate spot in faba bean.
Modeling and optimization of culture media for recombinant Helicobacter pylori vaccine antigen HpaA
Authors: Tan Runqing , Zhou Song , Sun Min , Liu Yu , Ni Xiumei , He Jin , Guo Gang , Liu Kaiyun 
Published: December 2024

IntroductionH. pylori (Helicobacter pylori) infection represents a significant global health concern, exacerbated by the emergence of drug-resistant strains resulting from conventional antibiotic treatments. Consequently, the development of vaccines with both preventive and therapeutic properties has become crucial in addressing H. pylori infections. The H. pylori adhesin protein HpaA has demonstrated strong immunogenicity across various adjuvants and dosage forms, positioning it as a key candidate antigen for recombinant subunit vaccines against H. pylori. Optimizing fermentation culture conditions is an effective strategy to enhance product yield and lower production costs. However, to date, there has been no systematic investigation into methods for improving the fermentation yield of HpaA. Enhancing the fermentation medium to increase HpaA yield holds significant potential for application and economic benefits in the prevention and detection of H. pylori infection.MethodsTo achieve a stable and high-yielding H. pylori vaccine antigen HpaA, this study constructed recombinant Escherichia coli expressing HpaA. The impact of fermentation medium components on the rHpaA yield was assessed using a one-factor-at-a-time approach alongside Plackett–Burman factorial experiments. Optimal conditions were effectively identified through response surface methodology (RSM) and artificial neural network (ANN) statistical computational models. The antigenicity and immunogenicity of the purified rHpaA were validated through immunization of mice, followed by Western Blot analysis and serum IgG ELISA quantification.ResultsGlucose, yeast extract, yeast peptone, NH4Cl and CaCl2 all contributed to the production of rHpaA, with glucose, yeast extract, and NH4Cl demonstrating particularly significant effects. The artificial neural network linked genetic algorithm (ANN-GA) model exhibited superior predictive accuracy, achieving a rHpaA yield of 0.61 g/L, which represents a 93.2% increase compared to the initial medium. Animal immunization experiments confirmed that rHpaA possesses good antigenicity and immunogenicity.DiscussionThis study pioneers the statistical optimization of culture media to enhance rHpaA production, thereby supporting its large-scale application in H. pylori vaccines. Additionally, it highlights the advantages of the ANN-GA approach in bioprocess optimization.
The effect of different activation irrigations on intracanal smear layer removal: a vitro study
Authors: Wang Lingxiang , Feng Bo , Shi Shaojing , Sun Degang , Wu Di 
Published: December 2024

ObjectiveTo compare the effect of syringe irrigation technique, passive ultrasonic activation technique, EDDY activation technique and Er,Cr,YSGG laser activation technique on smear layer removal in root canals in vitro.MethodsForty mandibular first premolars with single canal were collected from patients in Qingdao Stomatological Hospital affiliated to Qingdao University. After root canal preparation with ProTaper Universal to F3, they were randomly divided into four groups (n = 10) according to different activation irrigations for the final washing: syringe irrigation (SI), passive ultrasonic activation (PU), EDDY activation (EDDY) and Er,Cr,YSGG laser activation (YSGG). Finally, all the crowns of them were cut off and the root length was trimmed to 15 mm. The roots were split longitudinally and observed with scanning electron microscope (SEM) for assessment of smear layer removal in different parts of the root canal.ResultsAll groups showed similar effects for cleaning the root canals in the coronal thirds (P &gt; 0.05). For cleaning the root canals in the middle thirds, PU group, EDDY group and YSGG group showed similar effects, (P&gt; 0.05). They were more effective than SI group (P &lt; 0.05). For cleaning the root canals in the apical thirds, PU group and EDDY group showed similar effects (P&gt; 0.05). They were more effective than SI group (P &lt; 0.05). YSGG group was more effective than other groups (P &lt; 0.05).ConclusionEr,Cr,YSGG laser activation technique can remove smear layer of root canals effectively. The cleaning effect of the passive ultrasonic activation technique, EDDY activation technique is better than that of syringe irrigation technique.
The association of RBP4 with chronic kidney diseases in southern Chinese population
Authors: Chen Tong , Liu Yu , Wu Shiquan , Long Siyu , Feng Ling , Lu Wenqian , Chen Wenya , Hong Guoai , Zhou Li , Wang Fang , Luo Yuechan , Zou Hequn , Liu Weihua 
Published: December 2024

BackgroundRetinol binding protein 4 (RBP4), as a novel adipokine, has been proven to be highly related to insulin resistance, obesity, diabetes, hypertension, hyperuricemia and other metabolic diseases, which are all risk factors for chronic kidney disease (CKD). However, there is a lack of sufficient studies to explore the relationship between RBP4 and CKD, and no reports have described the predictive value of RBP4 for CKD. This study was designed to clarify the relationship between RBP4 and CKD and its potential predictive value.MethodsOur team has conducted a large-scale cross-sectional survey that contained 2117 individuals on the southern coast of China. Correlation test, logistic regression analysis were used to evaluate the association between RBP4 and CKD. Receiver operating characteristic (ROC) were used to evaluate the optimal cut-off and predictive value of RBP4 for predicting CKD.ResultsBy using the quartile grouping method, the population was divided into four groups according to the RBP4 level. As the RBP4 level increased, the prevalence of CKD also gradually increased among different groups. RBP4 was also correlated with various metabolic risk factors, such as blood glucose, blood lipids, blood pressure, waist circumference, uric acid, and with kidney function indicators such as creatinine, urine protein. Logistic regression analysis found that after adjusting for confounders, RBP4 remained significantly associated with CKD, independent of metabolic risk factors. ROC analysis showed that RBP4 as a single index, AUC (0.666) was superior to Scr, FBG, Log HOMA-IR, WC, TG, VLDL-C, UA, HDL-C, LDL-C, and that combining RBP4 indicator and other common risk factors of CKD can improve the accuracy for predicting CKD.ConclusionThis study found that the RBP4 was strongly correlated with CKD, RBP4 may become a valuable marker and have strong power for predicting CKD.
Maternal organokines throughout pregnancy as predictors of neonatal anthropometric characteristics and adiposity
Authors: Valencia-Ortega Jorge , Galicia-Hernández Victoria , Castillo-Santos Andrea , Molerés-Orduña Miranda , Arceo-Cerna Carla , Perichart-Perera Otilia , Rodríguez-Cano Ameyalli M. , Rodríguez-Hernández Carolina , Estrada-Gutierrez Guadalupe , Camacho-Arroyo Ignacio , Solis-Paredes Juan Mario 
Published: December 2024

AimsTo evaluate the relation between maternal concentrations of progranulin (PGRN), adipocyte fatty acid-binding protein (AFABP), brain-derived neurotrophic factor (BDNF), and fibroblast growth factor 21 (FGF21) throughout pregnancy with neonatal weight and length at birth and at one month of age, as well as with the percentage of fat mass at one month of age. Besides, we evaluated the association between maternal organokine concentrations with pregestational nutritional status and gestational weight gain (GWG).MethodsLongitudinal study of 100 healthy pregnant women and their neonates. Conventional biochemical tests were performed and maternal organokine concentrations were measured by ELISA. Neonatal percent fat mass was determined using the PEA POD system, and weight and length were measured using a soft tape measure and a baby scale. Multiple linear regression models were made to predict neonatal anthropometric measurements and adiposity.ResultsIn all women, PGRN concentrations significantly increased as pregnancy progressed, while AFABP concentrations increased until the third trimester and the highest BDNF concentrations were observed in the second trimester of pregnancy. In contrast, FGF21 concentrations did not change during pregnancy. Only maternal obesity was associated with some differences in AFABP and FGF21 concentrations. Gestational age at birth, maternal age and third-trimester PGRN concentrations predicted weight (gestational age at birth: β=0.11; maternal age: β=-0.033; PGRN: β=0.003, p&lt;0.001) and, together with first-trimester BDNF concentrations, length (gestational age at birth: β=0.76; maternal age: β=-0.21; PGRN: β=0.24; BDNF: β=0.06, p&lt;0.001) at birth. Maternal age and third-trimester BDNF concentrations predicted one-month-old neonate length (maternal age: β=-1.03; BDNF: β=0.45, p&lt;0.001). Pregestational body mass index (pBMI), GWG, second-trimester FGF21 concentrations, and third-trimester AFABP concentrations predicted neonatal fat mass percentage (pBMI: β=-0.58; GWG: β=-0.32; FGF21: β=-0.004; AFABP: β=-1.27, p&lt;0.001) at one month of age.ConclusionMaternal PGRN, AFABP, and BDNF concentrations, but not FGF21, vary throughout pregnancy. These organokines and maternal characteristics can be useful in the prediction of neonatal weight, length, and percentage fat mass.
The potential mechanisms underlying phthalate-induced hypospadias: a systematic review of rodent model studies
Authors: Zhang Youtian , Wang Jian , Yang Hongchao , Guan Yong 
Published: December 2024

ObjectivesMaternal exposure to environmental endocrine disruptors, such as phthalates, during pregnancy is a significant risk factor for the development of hypospadias. By consolidating existing research on the mechanisms by which phthalates induce hypospadias in rodent models, this systematic review aims to organize and analyze the discovered mechanisms and their potential connections.MethodsThe study involved all articles that explored the mechanisms of phthalate-induced hypospadias using rodent models. A comprehensive search of the PubMed and Web of Science databases was conducted using the terms “hypospadias” and “phthalates” before January 20, 2024. Then, two investigators screened for studies worthy of inclusion by setting inclusion and exclusion criteria.ResultsOf the initial 326 search results, 22 were included in the subsequent analysis. Based on the commonalities among different results, the mechanisms of phthalate-induced hypospadias could be categorized into the following five groups: sex steroids-related signaling pathways (n=10), epithelial-mesenchymal transition (n=6), autophagy (n=5), apoptosis (n=4) and angiogenesis (n=2). Among these, sex steroids-related signaling pathways might serve as a central regulator among all mechanisms, and reactive oxygen species (ROS) also played an important mediating role.ConclusionThe systematic review indicates that phthalates may initially disrupt the balance of sex steroids-related pathways, leading to abnormally elevated levels of ROS and subsequently to other functional abnormalities, ultimately resulting in the development of hypospadias. All these findings will help to improve prevention strategies during pregnancy to reduce the adverse effects of phthalates on the offspring.