bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric Assessment of the Post-Secondary Student Stressors Index (PSSI)
Authors: Linden Brooke , Stuart Heather 
Published: September 2019

Abstract
Background: Previous research has linked excessive stress among post-secondary students to poor academic performance and poor mental health. Despite attempts to ameliorate mental health challenges at post-secondary institutions, there exists a gap in the evaluation of the specific sources of stress for students within the post-secondary setting. Methods: The goal of this study was to develop a new instrument to better assess the sources of post-secondary student stress. Over the course of two years, the Post-Secondary Student Stressors Index (PSSI) was created in collaboration with post-secondary students as co-developers and subject matter experts. In this study, we used a combination of individual cognitive interviews (n = 11), an online consensus survey modeled after a traditional Delphi method (n = 65), and an online pre- (n = 535) and post-test (n = 350) survey to psychometrically evaluate the PSSI using samples of students from Ontario, Canada. We collected four types of evidence for validity, including: content evidence, response processes evidence, internal structure evidence, and relations to other variables. The test-retest reliability of the instrument was also evaluated. Results: The PSSI demonstrated strong psychometric properties. Content validation and response processes evidence was derived from active student involvement throughout the development and refinement of the tool. Exploratory factor analysis suggested that the structure of the PSSI reflects the internal structure of an index, rather than a scale, as expected. Test-retest reliability of the instrument was comparable to existing, established instruments. Finally, the PSSI demonstrated good relationships with like measures of stress, distress, and resilience, in the hypothesized directions. Conclusions: The PSSI is a 46-item inventory that will allow post-secondary institutions to pinpoint the most severe and frequently occurring stressors on their campus. This knowledge will facilitate appropriate targeting of priority areas, and help institutions to better align their mental health promotion and mental illness prevention programming with the needs of their campus.
Long Term Surgical Outcomes For Infective Endocarditis In People Who Inject Drugs: A Systematic Review And Meta-Analysis
Authors: Goodman-Meza David , Weiss Robert E , Gamboa Sebastian , Gallegos Abel , Bui Alex AT , Goetz Matthew B , Shoptaw Steve , Landovitz Raphael J 
Published: September 2019

Abstract
Background: In the United States, the number of infective endocarditis (IE) cases associated with injection drug use has increased. Clinical guidelines suggest deferring surgery for IE in people who inject drugs (PWID) due to a concern for worse outcomes in comparison to non-injectors (non-PWID). We performed a systematic review and meta-analysis of long-term outcomes in PWID who underwent cardiac surgery and compared these outcomes to non-PWID.
Methods: We systematically searched for studies reported between 1965 and 2018. We used an algorithm to estimate individual patient data (eIPD) from Kaplan-Meier (KM) curves and combined it with published individual patient data (IPD) to analyze long-term outcomes after cardiac surgery for IE in PWID . Our primary outcome was survival. Secondary outcomes were reoperation and mortality at 30-days, one-, five-, and 10-years. Random effects Cox regression was used for estimating survival.
Results: We included 27 studies in the systematic review and 19 provided data (KM or IPD) for the meta-analysis. PWID were younger and more likely to have S. aureus than non-PWID. Survival at 30-days, one-, five-, and 10-years was 94.3%, 81.0%, 62.1%, and 56.6% in PWID, respectively; and 96.4%, 85.0%, 70.3%, and 63.4% in non-PWID. PWID had 47% greater hazard of death (HR 1.47, 95% CI, 1.05-2.05) and more than twice the hazard of reoperation (HR 2.37, 95% CI, 1.25-4.50) than non-PWID.
Conclusion: PWID were younger and had shorter survival that non-PWID. Implementing evidence-based interventions and testing new modalities are urgently needed to improve outcomes in PWID after cardiac surgery.
WITHDRAWN: Evaluation of two faecal occult blood diagnostic tests for detection of non-perforating abomasal lesions in cattle
Authors: Munch Sara Lee , Nielsen Søren Saxmose , Krogh Mogens Agerbo , Capion Nynne 
Published: September 2019

Abstract
Non-perforating abomasal lesions have been observed with a high prevalence in slaughtered dairy cattle. Of all lesions found 62-66% were reported to be bleeding and 41-44% were reported to be chronic. The diagnostic properties of two faecal occult blood tests for detection abomasal lesions were evaluated. First, an in vitro titration test was used to determine the detection limit for blood in faeces for each of the tests. A tetramethylbenzidine-based test detected 2 ml blood and a guaiac-based test detected 4.5 ml of blood per 1,000 g faeces. Then, to determine if blood is degraded by rumen microbes, an in vitro study of blood fermentation in rumen fluid was conducted. Blood or haemoglobin in the quantities used did not break down when fermented for 48 hours. Lastly, faeces from 1,553 cattle was collected in a slaughterhouse and tested for the presence of blood the same day and 2 days after. The faecal results were compared with the presence of abomasal lesions in the cattle investigated. Cattle with ≥ 4 lesion subtypes considered to be bleeding had more positive test results. Cattle with ≥ 4 subtype Ib lesions had 1.7 times higher odds of testing positive in the tetramethylbenzidine test on Day 2 (95% confidence interval: 1.4 – 1.9) and cattle with ≥ 4 subtype Ic lesions had 1.9 times higher odds of testing positive (95% confidence interval: 1.6 – 2.3). However, 20% false-positive results were also observed, and a positive test can not necessarily be interpreted as the cow having abomasal lesions.
Effect of adjuvant chemotherapy on survival benefit in stage III colon cancer patients stratified by age: a Japanese real-world cohort study
Authors: Kawamura Hidetaka , Morishima Toshitaka , Sato Akira , Honda Michitaka , Miyashiro Isao 
Published: September 2019

Abstract
Background: Adjuvant chemotherapy is relatively underused in older patients with colon cancer in Japan, and its age-specific effects on clinical outcomes remain unclear. This study aimed to assess the effect of adjuvant chemotherapy on survival benefit in stage III colon cancer patients stratified by age in a Japanese real-world setting. Methods: In this multi-center retrospective cohort study, we analyzed patient-level information through a record linkage of population-based cancer registry data and administrative claims data. The study population comprised patients aged ≥18 years who received a pathological diagnosis of stage III colon cancer and underwent curative resection between 2010 and 2014 at 36 cancer care hospitals in Osaka Prefecture, Japan. Patients were divided into two groups based on age at diagnosis (<75 and ≥75 years). The effect of adjuvant chemotherapy was analyzed using Cox proportional hazards regression models for all-cause mortality with inverse probability weighting of propensity scores. Adjusted hazard ratios were estimated for both age groups. Results: A total of 783 patients were analyzed; 476 (60.8%) were aged <75 years and 307 (39.2%) were aged ≥75 years. The proportion of older patients who received adjuvant chemotherapy (36.8%) was substantially lower than that of younger patients (73.3%). In addition, the effect of adjuvant chemotherapy was different between the age groups: the adjusted hazard ratio was 0.56 (95% confidence interval: 0.33-0.94, P =0.027) in younger patients and 1.07 (0.66-1.74, P =0.78) in older patients. Conclusions: The clinical effectiveness of adjuvant chemotherapy in older patients with stage III colon cancer appears limited under current utilization practices.
Prognosis of Colorectal Cancer in Tikur Anbessa Specialized Hospital, the Only Oncology Center in Ethiopia
Authors: Etissa Eyob Kebede , Assefa Mathewos Assefa , Ayele Birhanu Teshome 
Published: September 2019

Abstract
BACKGROUND: Colorectal cancer is the third most commonly diagnosed cancer in males and the second in females worldwide. According to Addis Ababa cancer registry, it is the first in male and fourth in female in Ethiopia. However, there have not been studies on prognostic factors and survival of colorectal cancer. Hence, this study aimed to estimate survival time and identify prognostic factors. METHODS: In this institution based retrospective study, medical records review of 422 colorectal cancer patients and telephone interview was used as sources of data. Survival time was estimated using Kaplan-Meier estimator. Prognostic factors were identified using the multivariable Cox regression model. RESULTS: The median survival time was 39 months. The overall five years survival rate was 33%. Patients diagnosed with rectal cancer had 76% (HR: 1.761, 95% CI: 1.173-2.644) increased risk to die compared to colon cancer patients. Node positive patients were 3.146 (95% CI: 1.626-6.078) times likely to die compared to node negative and metastatic cancer were 4.221 (95% CI: 2.788-6.392) times likely to die compared to non-metastatic patients. Risk of death was 36.1% lesser (HR: 0.639 (95% CI: 0.418-0.977)) among those who received adjuvant therapy compared to patients who had only surgical resection. CONCLUSION: The overall survival rate is low and majority of patients were young adults at presentation. Patient’s survival is largely influenced by advanced stage at presentation and delays in administration of adjuvant therapy. Adjuvant therapy was among the good prognostic factors. Implementation of colorectal cancer screening program and early detection with timely and advanced treatment are crucial to increase patients’ survival time. KEY WORDS: Colorectal cancer, survival, prognostic factor, Cox regression, Tikur Anbessa Specialized Hospital, Addis Ababa.
Impact of a semi-structured briefing on the management of adverse events in anesthesiology: A randomized pilot study.
Authors: Neuhaus Christopher , Schäfer Johannes , Weigand Markus A. , Lichtenstern Christoph 
Published: September 2019

Abstract
Background : Human factors research has identified mental models as a key component for the effective sharing and organization of knowledge. The challenge lies in the development and application of tools that help team members to arrive at a shared understanding of a situation. The aim of this study was to assess the influence of a semi-structured briefing on the management of a simulated airway emergency.
Methods : 37 interprofessional teams were asked to perform a simulated rapid-sequence induction in the simulator. Teams were presented with a “cannot ventilate, cannot oxygenate” scenario that ultimately required a cricothyroidotomy. Study group (SG) teams were asked to perform a briefing prior to induction, while controls (CG) were asked to perform their usual routine.
Results : We observed no difference in the mean time until cricothyroidotomy (SG 8:31 CG 8:16, p=0.36). There was a significant difference in groups’ choice of alternative means of oxygenation: While SG teams primarily chose supraglottic airway devices, controls initially reverted to mask ventilation (p=0.005). SG teams spent significantly less time with this alternative airway device and were quicker to advance in the airway algorithm.
Conclusions : Our study addresses effects on team coordination through a shared mental model as effected by a briefing prior to anesthesia induction. We found measurable improvements in airway management during those stages of the difficult airway algorithm explicitly discussed in the briefing. For those, time spent was shorter and participants were quicker to advance in the airway algorithm.
Detection of expression of microRNAs in serum of loco-regionally advanced nasopharyngeal carcinoma patients: A potential marker for prognosis prediction of nasopharyngeal carcinoma treated with concurrent chemoradiotherapy screening
Authors: Zhang Zhimin , Wang Ge , Jin Feng , Zheng Jijun , Xiao He , Lei Lin , Luo Jia , Chen Chuan 
Published: September 2019

Abstract
Background Serum miRNA signature has recently been found as potential disease fingerprints to predict survival. Therefore we investigated the role of serum miRNA in predicting prognosis in patients with loco-regionally advanced nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy (CCRT). Methods This study included two phases: (i) We enrolled 3 NPC patients with recurrence or distant metastasis (experimental group, EG) and 3 NPC patients in clinical remission (control group, CG), who were treated with CCRT within 5 years. The paired serum was collected before and after treatment and biomarkers were discovered by TaqMan Human MiRNA Arrays. (ii) we used the bioinformatic analysis, marker selection and an independent validation by qRT-PCR to analyse the serums of 29 NPC patients with recurrent disease or distant metastasis and 19 NPC patients treated with CCRT. We used the Kaplan-Meier method, log-rank test and Cox regression model to estimate the accuracy of the miRNAs to predict PFS and OS, and identified factors significantly associated with prognosis, respectively. Results Using fold change≥2.0 or ≤0.5 and p≤0.05 as a cutoff level, we identified 1 up-regulated and 9 down-regulated miRNAs, 1 up-regulated and 6 down-regulated miRNAs in EG versus CG before and after CCRT, respectively. After significantly down-regulated miRNA from EG versus CG before and after CCRT were removed, only 9 different miRNAs were significantly reduced. In an independent set of serum samples, the expression of miR-26b, miR-29a and miR-125b showed no significant difference in 48 NPC patients before CCRT. The expression of miR-143 and miR-29b showed no significantly difference between the two groups after CCRT. We calculated a risk score from the expression of miR-26b、miR-29a、miR-125b、miR-29b、miR-143 and then classified patients as with high or low risk. Compared to patients with low-risk score, high-risk patients had shorter PFS and OS. Cox regression model suggested that combining serum miR-29a and miR-125b before CCRT with miR-26b after CCRT was independent prognostic factors for PFS, whereas combining the former two is independent for OS. Conclusions Combined expression of serum miR-29a, miR-125b and miR-26b might provide prognostic value in loco-regionally advanced NPC patients treated with CCRT, especially for high-risk progression patients.
Effect of luseogliflozin on bone microarchitecture in elderly patients with type 2 diabetes: Study protocol for a randomized controlled trial using second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT)
Authors: Haraguchi Ai , Shigeno Riyoko , Horie Ichiro , Morimoto Shimpei , Ito Ayako , Chiba Ko , Kawazoe Yurika , Tashiro Shigeki , Miyamoto Junya , Sato Shuntaro , Yamamoto Hiroshi , Osaki Makoto , Kawakami Atsushi , Abiru Norio 
Published: September 2019

Abstract
Background Elderly patients with type 2 diabetes mellitus (T2DM) have an increased risk of bone fracture independent of their bone mineral density (BMD), which is explained mainly by the deteriorated bone quality in T2DM compared to non-diabetic adults. Sodium-glucose co-transporter (SGLT) 2 inhibitors have been studied in several trials in T2DM, and the Canagliflozin Cardiovascular Assessment Study showed an increased fracture risk related to treatment with the SGLT2 inhibitor canagliflozin, although no evidence of increased fracture risk with treatment with other SGLT2 inhibitors has been reported. The mechanism of the difference in the fracture risk between the SGLT2 inhibitors is unknown, but the differences among the SGLT2 inhibitors in the selectivity of SGLT2 against SGLT1 may affect bone metabolism, since among the SGLT2 inhibitors the selectivity of canagliflozin is lowest. We will investigate whether the SGLT2 inhibitor luseogliflozin, which has higher SGLT2 selectivity, affects bone metabolism by using high-resolution peripheral quantitative computed tomography (HR-pQCT) which provides direct in vivo morphometric information about the bone microarchitecture.Methods This is a single-center, randomized, open-label, active-controlled, parallel pilot trial. Eligible participants are elderly (age ≥60 years) individuals with T2DM with HbA1c levels at 7.0%–8.9%. A total of 24 participants will be allocated to either the luseogliflozin group (taking luseogliflozin) or control group (taking metformin) in a 1:1 ratio to compare the groups' changes in bone microarchitecture of radius and tibia which are analyzed by HR-pQCT before and 48 weeks after the administration of each medication. The laboratory data associated with glycemic control and bone metabolism will be collected every 12 weeks during the study. Recruitment began in June 2019.Discussion The reason we use metformin as an active control is to avoid yielding differences in glycemic control between the luseogliflozin and control groups. Besides, metformin is considered to have neutral effect on bone. This trial will reveal the effect of luseogliflozin on bone metabolism in elderly patients with T2DM.
Parental relationship and child development: A study protocol for a randomized controlled trial for strengthening couples and children from pregnancy until four years after birth
Authors: Bodenmann Guy , Stadelmann Céline , Zimmermann Peter , Iwanski Alexandra , Senn Mirjam , Milek Anne , Rauch-Anderegg Valentina , Meier Fabienne 
Published: September 2019

Abstract
Background The transition to parenthood is a critical phase for couples and often relationship relational well-being (i.e., relationship satisfaction) deteriorates. As parents’ relationship well-being is a significant predictor of children’s well-being, this decrease is also critical for children. Thus, strengthening couples during the transition to parenthood seems particularly important. Different intervention programmes targeting the transition to parenthood reported positive effects on relationship satisfaction, communication and child adjustment. This study protocol describes a randomized controlled trial for two couple-focused interventions, targeting the enhancement of partners’ relational skills (communication, dyadic coping, problem-solving, self-regulation in relationships) with the aim to improve relational well-being, partners’ well-being, coparenting and, consequently, foster healthy child development.Methods/design We randomly assigned mixed-sex couples to a high or low dose intervention or a waiting list control condition. The high dose intervention consists of a training of relational skills, whereas in the low dose condition participants receive a psychoeducational movie. Outcomes are assessed over 11 time points from the third trimester of pregnancy until four years after birth assessing self-report and home observations of couple- and parent-child interactions. Primary outcomes include relational skills, individual and relational well-being and coparenting; a secondary outcome is healthy child development. Statistical analyses include multilevel modelling, structural equation modelling as well as standard statistics.Discussion The aim of this study is to support families with couple-focused interventions and thus improve relational skills, relationship well-being, coparenting, individual well-being, and healthy child development. If the intervention reveals to be effective, we will target a broader dissemination.
Kinetika Perubahan Sifat Fisik dan Kadar Tanin Biji Sorgum (Sorghum Bicolor L.) Selama Perendaman
Authors: Asropi Asropi , Bintoro Nursigit , Karyadi Joko Nugroho Wahyu , Rahayoe Sri , Saputro Arifin Dwi 
Published: September 2019

Some studies have been done to examine that the soaking process of sorghum seeds decrease the tannin level, but have not yet examined the kinetics of reaction changes during soaking. The aim of this experiment was to study the kinetics of changes on physical characteristics and tannin level of sorghum seeds during soaking. This experiment used milled and not milled red sorghum seeds which were soaked for 24 hours in distilled and alkaline solution at 30, 45, and 60 ºC. Observed parameters included water content, tannin content, and hardness, which were analyzed using statistical data and the kinetics of parameter change rate. Temperature treatment had a significant effect on the changes in all parameters of sorghum seeds during soaking. The increase in temperature accelerated the diffusion coefficient (Deff) in a range between 6.6345x10-12 m2/second to 13.5519x10-12 m2/second and energy activation of 8.054 kJ/mol; 3.274 kJ/mol; 3.183 kJ/mol; and 7.29 kJ/mol on the distilled water soaking treatment of not milled sorghum seeds, alkaline soaking treatment of not milled seeds, the distilled water soaking treatment of milled sorghum seeds, and alkaline soaking treatment of milled seeds. The highest decrease in tannin content was 77.9%, that was obtained in the treatment of alkaline soaking treatment of milled seeds at 60 ºC. The highest increase in volume occurred in the treatment of alkaline soaking treatment of milled seeds (76.0%). The value of the constant rate tended to increase with the increasing temperature of the soaking process. This means that the changes in the parameter were faster at a higher temperature, so the energy activation used is lower.
Food actvism. Agency, democracy and economy
Authors: Gravante Tommaso 
Published: September 2019

<p class="p1"><span class="s1">La relación entre alimentación, política y acción colectiva no es nueva. La alimentación es un símbolo potente de lo que aflige a la sociedad, es una forma de transformar cuestiones como las clases sociales o la explotación en una realidad material y visceral. No hace falta recordar los motines populares —<em>bread riots</em>— en la Inglaterra del siglo dieciocho o los motines populares en Italia de 1898, llamados también las protestas del estómago —<em>le proteste dello stomaco</em>—. Ambos fenómenos sociales, y, como muchos otros casos similares a lo largo de la historia y del planeta, fueron guiados por el injusto aumento del precio del pan, de los impuestos sobre el trigo, el maíz, etcétera.<span class="Apple-converted-space"> </span></span></p>
KENDALA DAN UPAYA PENGEMBANGAN OBJEK WISATA BONO DI SUNGAI KAMPAR KECAMATAN TELUK MERANTI KABUPATEN PELALAWAN RIAU
Authors: Rianto Slamet , Santri Santri 
Published: September 2019

Bono attractions Teluk Meranti in the Kampar river has long been known by the local community and society outside the area.. The potential development of one of the tourist destinations of special interest is very great because not only the arrival of world-class surfers are also attracted families join surfers to enjoy the beauty of Teluk Meranti village that has not been untouched by modernization. The study aimed to collect data and analyze data on: 1) The potential attraction owned by Bono. 2) Constraints faced in the development of attractions Bono. 3) The efforts made by the government and the community in the development of attractions Bono. This type of research is qualitative using interviews, observation and research directly spaciousness. The results of research in the field as follows: 1) The potential attraction that Bono Bono has become Icon in provincial and national. 2) Constraints faced in the development of attractions Bono among others: Street who has not been on the tarmac, villa or venue that is still inadequate, stalls where to eat the tourists are still lacking, there is no public transportation to transport tourists. 3) The efforts made by the government and the community in the development of attractions Bono is to prepare themselves in order to promote activities pariwisatai does not eliminate their cultural identity. Keywords: Constraints and Development Efforts Attractions Bono