bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relative lethal toxicity of pharmaceutical and illicit substances: A 16‐year study of the Greater Newcastle Hunter Area, Australia
Authors: Brett Jonathan , Wylie Claire E. , Raubenheimer Jacques , Isbister Geoff K. , Buckley Nick A. 
Published: June 2019

AimsWe aim to calculate 2 metrics of relative lethal toxicity; the fatal toxicity index (FTI; number of deaths per year of a daily dose) and the case fatality (CF; number of deaths per overdose) with a focus on opioids, antidepressants, antipsychotics, benzodiazepines and illicit drugs.MethodsThis descriptive cohort study used the Australian National Coronial Information System (NCIS) to identify a population of individuals with drug‐associated deaths in the Greater Newcastle Hunter Area between January 2002 and December 2016. This was combined with Australian medicine dispensing data and corresponding data from the Hunter Area Toxicology Service to calculate FTI and CF.ResultsThere were 444 drug‐related deaths and 21,296 overdoses during the study period. FTI and CF were well correlated (Spearman's rho 0.64, P < .001). Of the classes of interest, opioids had the highest FTI (40.3 95% confidence interval [CI] 35.2–45.4 deaths per 100 years of use at the defined daily dose or deaths/DDD/100 years) and CF (12.4% 95%CI 11.0–13.9). Fentanyl, methadone and morphine had the highest relative fatal toxicity within this class. Tricyclic antidepressants had the highest relative fatal toxicity of all antidepressants (FTI 14.5 95%CI 9.7–19.3 deaths/DDD/100 years and CF 7.1% [95%CI 4.8–9.3]) and benzodiazepines appeared to be more associated with multiple agent deaths than single. Of the illicit drugs, heroin had the highest CF (26.4%, 95%CI 19.1–33.7).ConclusionKnowledge of relative lethal toxicity is useful to prescribers and medicines and public health policy makers in restricting access to more toxic drugs and may also assist coroners in determining cause of death.
Cyclin D1 expression and novel mutational findings in Rosai‐Dorfman disease
Authors: Baraban Ezra , Sadigh Sam , Rosenbaum Jason , Van Arnam John , Bogusz Agata M. , Mehr Chelsea , Bagg Adam 
Published: June 2019

SummaryRosai‐Dorfman disease (RDD) is an enigmatic histiocytic disorder classically diagnosed by a distinctive combination of pathological features: emperipolesis, or migration of intact haematological cells through the voluminous cytoplasm of lesional histiocytes, and expression of S100 by these histiocytes. The pathogenesis has long been elusive until the recent detection of recurrent and mutually exclusive mutations in several oncogenes in the mitogen‐activated protein kinase (MAPK) pathway. Based on these findings, we investigated a cohort of 21 RDD patients and found that the lesional histiocytes in 86% (18/21) of patients exhibited strong and diffuse nuclear Cyclin D1 expression, which not only may provide a diagnostic marker for this sometimes pathologically challenging disease, but also probably reflects constitutive MAPK pathway activation because we additionally identified phosphorylated‐ERK expression in 90% (19/21) of cases. Further, we performed massively parallel sequencing on a subset (6/18) of the CyclinD1 positive cases, identifying several mutations that have not been previously reported in RDD. Taken together, our findings bolster the concept of RDD as a disease of MAPK activation in a substantial percentage of cases and enhance the current understanding of the pathogenesis of RDD.
Procedural Tectonic Planets
Authors: Cortial Y. , Peytavie A. , Galin E. , Guérin E. 
Published: June 2019

AbstractWe present a procedural method for authoring synthetic tectonic planets. Instead of relying on computationally demanding physically‐based simulations, we capture the fundamental phenomena into a procedural method that faithfully reproduces large‐scale planetary features generated by the movement and collision of the tectonic plates. We approximate complex phenomena such as plate subduction or collisions to deform the lithosphere, including the continental and oceanic crusts. The user can control the movement of the plates, which dynamically evolve and generate a variety of landforms such as continents, oceanic ridges, large scale mountain ranges or island arcs. Finally, we amplify the large‐scale planet model with either procedurally‐defined or real‐world elevation data to synthesize coherent detailed reliefs. Our method allows the user to control the evolution of an entire planet interactively, and to trigger specific events such as catastrophic plate rifting.
Dual Sheet Meshing: An Interactive Approach to Robust Hexahedralization
Authors: Takayama Kenshi 
Published: June 2019

AbstractThe combinatorial dual of a hex mesh induces a collection of mutually intersecting surfaces (dual sheets). Inspired by Campen et al.'s work on quad meshing [CBK12, CK14], we propose to directly generate such dual sheets so that, as long as the volume is properly partitioned by the dual sheets, we are guaranteed to arrive at a valid all‐hex mesh topology. Since automatically generating dual sheets seems much harder than the 2D counterpart, we chose to leave the task to the user; our system is equipped with a few simple 3D modeling tools for interactively designing dual sheets. Dual sheets are represented as implicit surfaces in our approach, greatly simplifying many of the computational steps such as finding intersections and analyzing topology. We also propose a simple algorithm for primalizing the dual graph where each dual cell, often enclosing singular edges, gets mapped onto a reference polyhedron via harmonic parameterization. Preservation of sharp features is simply achieved by modifying the boundary conditions. We demonstrate the feasibility of our approach through various modeling examples.
A Geometrically Consistent Viscous Fluid Solver with Two‐Way Fluid‐Solid Coupling
Authors: Takahashi Tetsuya , Lin Ming C. 
Published: June 2019

AbstractWe present a grid‐based fluid solver for simulating viscous materials and their interactions with solid objects. Our method formulates the implicit viscosity integration as a minimization problem with consistently estimated volume fractions to account for the sub‐grid details of free surfaces and solid boundaries. To handle the interplay between fluids and solid objects with viscosity forces, we also formulate the two‐way fluid‐solid coupling as a unified minimization problem based on the variational principle, which naturally enforces the boundary conditions. Our formulation leads to a symmetric positive definite linear system with a sparse matrix regardless of the monolithically coupled solid objects. Additionally, we present a position‐correction method using density constraints to enforce the uniform distributions of fluid particles and thus prevent the loss of fluid volumes. We demonstrate the effectiveness of our method in a wide range of viscous fluid scenarios.
StyleBlit: Fast Example‐Based Stylization with Local Guidance
Authors: Sýkora D. , Jamriška O. , Texler O. , Fišer J. , Lukáč M. , Lu J. , Shechtman E. 
Published: June 2019

AbstractWe present StyleBlit—an efficient example‐based style transfer algorithm that can deliver high‐quality stylized renderings in real‐time on a single‐core CPU. Our technique is especially suitable for style transfer applications that use local guidance ‐ descriptive guiding channels containing large spatial variations. Local guidance encourages transfer of content from the source exemplar to the target image in a semantically meaningful way. Typical local guidance includes, e.g., normal values, texture coordinates or a displacement field. Contrary to previous style transfer techniques, our approach does not involve any computationally expensive optimization. We demonstrate that when local guidance is used, optimization‐based techniques converge to solutions that can be well approximated by simple pixel‐level operations. Inspired by this observation, we designed an algorithm that produces results visually similar to, if not better than, the state‐of‐the‐art, and is several orders of magnitude faster. Our approach is suitable for scenarios with low computational budget such as games and mobile applications.
A Low‐Dimensional Function Space for Efficient Spectral Upsampling
Authors: Jakob Wenzel , Hanika Johannes 
Published: June 2019

AbstractWe present a versatile technique to convert textures with tristimulus colors into the spectral domain, allowing such content to be used in modern rendering systems. Our method is based on the observation that suitable reflectance spectra can be represented using a low‐dimensional parametric model that is intrinsically smooth and energy‐conserving, which leads to significant simplifications compared to prior work. The resulting spectral textures are compact and efficient: storage requirements are identical to standard RGB textures, and as few as six floating point instructions are required to evaluate them at any wavelength. Our model is the first spectral upsampling method to achieve zero error on the full sRGB gamut. The technique also supports large‐gamut color spaces, and can be vectorized effectively for use in rendering systems that handle many wavelengths at once.
Clear Skies Ahead: Towards Real‐Time Automatic Sky Replacement in Video
Authors: Halperin Tavi , Cain Harel , Bibi Ofir , Werman Michael 
Published: June 2019

AbstractDigital videos such as those captured by a smartphone often exhibit exposure inconsistencies, a poorly exposed sky, or simply suffer from an uninteresting or plain looking sky. Professionals may edit these videos using advanced and time‐consuming tools unavailable to most users, to replace the sky with a more expressive or imaginative sky. In this work, we propose an algorithm for automatic replacement of the sky region in a video with a different sky, providing nonprofessional users with a simple yet efficient tool to seamlessly replace the sky. The method is fast, achieving close to real‐time performance on mobile devices and the user's involvement can remain as limited as simply selecting the replacement sky.
Multi‐Pose Interactive Linkage Design
Authors: Nishida G. , Bousseau A. , Aliaga D. G. 
Published: June 2019

AbstractWe introduce an interactive tool for novice users to design mechanical objects made of 2.5D linkages. Users simply draw the shape of the object and a few key poses of its multiple moving parts. Our approach automatically generates a one‐degree‐of freedom linkage that connects the fixed and moving parts, such that the moving parts traverse all input poses in order without any collision with the fixed and other moving parts. In addition, our approach avoids common linkage defects and favors compact linkages and smooth motion trajectories. Finally, our system automatically generates the 3D geometry of the object and its links, allowing the rapid creation of a physical mockup of the designed object.
What's in a Face? Metric Learning for Face Characterization
Authors: Sendik O. , Lischinski D. , Cohen‐Or D. 
Published: June 2019

AbstractWe present a method for determining which facial parts (mouth, nose, etc.) best characterize an individual, given a set of that individual's portraits. We introduce a novel distinctiveness analysis of a set of portraits, which leverages the deep features extracted by a pre‐trained face recognition CNN and a hair segmentation FCN, in the context of a weakly supervised metric learning scheme. Our analysis enables the generation of a polarized class activation map (PCAM) for an individual's portrait via a transformation that localizes and amplifies the discriminative regions of the deep feature maps extracted by the aforementioned networks. A user study that we conducted shows that there is a surprisingly good agreement between the face parts that users indicate as characteristic and the face parts automatically selected by our method. We demonstrate a few applications of our method, including determining the most and the least representative portraits among a set of portraits of an individual, and the creation of facial hybrids: portraits that combine the characteristic recognizable facial features of two individuals. Our face characterization analysis is also effective for ranking portraits in order to find an individual's look‐alikes (Doppelgängers).
Influence of the fixed implant‐supported provisional phase on the esthetic final outcome of implant‐supported crowns: 3‐year results of a randomized controlled clinical trial
Authors: Furze David , Byrne Ashley , Alam Sonia , Brägger Urs , Wismeijer Daniel , Wittneben Julia‐Gabriela 
Published: June 2019

AbstractObjectivesThe aim of this investigation was to evaluate whether the use of a provisional implant‐supported crown improves the final esthetic outcome of implant crowns that are placed within esthetic sites.Materials and MethodsTwenty endosseous implants were inserted in sites 13 to 23 (FDI) in 20 patients. Following the reopening procedure, a randomization process assigned them to either cohort group 1: a provisional phase with soft tissue conditioning using the “dynamic compression technique” or cohort group 2: without a provisional phase. Screw‐retained all ceramic crowns were inserted. Clinical follow‐up appointments were completed at 36 months evaluating clinical, radiographic outcomes, and implant success and survival.ResultsAfter 3 years, all implants survived; one implant‐supported crown was excluded from the study due to adjacent tooth failure replaced with a further implant supported crown. Modified pink esthetic score (ModPES) scores were significantly different between groups 1 and 2 (P = .018); white esthetic scores (WES) were not statistically different between both groups (P = .194). Mean values of combined modPES and WES were 15.6 for group 1, with a SD of 3.20. Group 2 had a mean combined modPES and WES of 12.2, with a SD of 3.86. Mean bone loss after 3 year was −0.05 and −0.04 mm for groups 1 and 2 respectively, without being statistically significant.ConclusionFixed implant‐supported provisionals improve the final esthetic outcome of the peri‐implant mucosa.
Modelling species distributions to predict areas at risk of invasion by the exotic aquatic New Zealand mudsnail Potamopyrgus antipodarum (Gray 1843)
Authors: Alexandre da Silva Marcos Vinicios , Nunes Souza João Vitor , de Souza José Roberto Botelho , Vieira Leandro M. 
Published: June 2019

Abstract

The use of bioclimatic models to predict areas subject to invasion by exotic species has been important in the development of preventive conservation measures. The native New Zealand mudsnail Potamopyrgus antipodarum is an invasive mollusc, now with a worldwide distribution, that causes economic and ecological problems in invaded areas and has recently been designated as one of the 100 worst invasive species in Europe.

In this study we sought to determine the potential distribution of and areas susceptible to invasion by P. antipodarum in South America and worldwide, in present and future scenarios (2070), using MaxEnt models. The models were developed using georeferenced occurrence data and bioclimate and hydroclimate variables to predict scenarios of the geographical distribution of P. antipodarum. Possible routes of invasion into South America were predicted.

Present‐day scenario of the worldwide distribution (all known occurrences) of P. antipodarum, based on the bioclimatic and hydroclimatic models, are highly accurate, with area under curve higher than of 0.87. The models indicated that environmentally suitable areas exist in South America and in other regions of the world where the species has not yet been recorded. The predicted susceptibility includes approximately 80 protected areas in the South American continent.

Models projected in an optimistic and pessimistic future scenario, based on the worldwide distribution, show increased environmental suitability of regions outside the current species distribution, including Brazil (south‐west), Uruguay (near Mirim Lagoon), Nigeria, Ethiopia (lakes Tana and Chomen), Tanzania, Cameroon (bordering lakes Bamendjing, Bankim, and Mbakaou), Equatorial Guinea, Congo, Rwanda, Burundi (Lake Tanganyika environs), Uganda, Tanzania (Naivasha), and South Africa (surrounding Gordon's Bay).

The main vector for dispersal to South America would be ballast water coming from waterways and ports located in the predicted areas. Fish farming is also a possible route, since the mudsnail is resistant to the digestive tract of rainbow trout (Oncorhynchus mykiss). Current records and predicted susceptible areas coincide with port areas and sites where this fish is farmed.

Geographical distribution modelling proved to be helpful in identifying environmentally suitable areas for the invasion of P. antipodarum. The model also suggests a future expansion of the species distribution, possibly affected by climate change.
Violence against nurses working in the health sector in five European countries—pilot study
Authors: Babiarczyk Beata , Turbiarz Agnieszka , Tomagová Martina , Zeleníková Renáta , Önler Ebru , Sancho Cantus David 
Published: June 2019

AbstractAimTo provide initial data regarding country‐specific evidence of workplace violence towards nurses working within the health sector in five European countries.MethodsThis is a descriptive and cross‐sectional pilot study, conducted in June 2016. The sample consisted of 260 nurses working in selected health care settings in five participating countries (Poland, Czech Republic, Slovakia, Turkey, and Spain). The questionnaire used was adapted from the International Labour Office/International Council of Nurses/World Health Organisation/Public Services International Workplace Violence in the Health Sector Country Case Study—Questionnaire.ResultsA large number of participants confirmed that they had been physically attacked or verbally abused in the workplace in the last 12 months. In most cases, the physical and verbal abuse was inflicted by patients and to a lesser degree by relatives of patients, staff members, or managers/supervisors. In the majority of cases, no action was taken to investigate the causes of the incidents. In most cases, participants believed there was no point in reporting the incidents. However, the reasons for not reporting or discussing incidents of workplace violence varied depending on the country.ConclusionWorkplace violence towards nurses is a serious problem internationally, and violence prevention strategies need to be implemented.
Further discussion on the Eocene drowning of New Caledonia: Discordances from the point of view of zoology
Authors: Giribet Gonzalo , Baker Caitlin M. 
Published: June 2019

AbstractWe discuss the fauna of New Caledonia in the context of the prolonged submergence of Grande Terre until its re‐emergence around 37 million years ago and whether the resulting fauna can be entirely explained by over‐water dispersal. The current literature discussing the predominant neoendemism in New Caledonia is reviewed, questioning some of the discourse about how the fact that most animal and plant lineages are neoendemics should weigh in to disregard the fewer cases of paleoendemism (clades that have persisted and diversified in New Caledonia for over 37 million years). We argue that many of the examples used in the literature, selected for other purposes, were not chosen to test this particular hypothesis, but several old lineages of non‐vagile animals show that a non‐trivial number of clades have a history that predates the supposed emergence of New Caledonia. We conclude by posing the question of how much additional evidence should be needed to demonstrate a discordance between the geological history of the archipelago and the evolutionary history of its biota.
Judicial Educators’ Perspectives on Trauma Education for the Judiciary
Authors: Marsh Shawn C. 
Published: June 2019

AbstractTrauma and its impact on human development and functioning in the context of legal systems has been an important topic in judicial education for well over a decade. This brief report reviews key components of this work since approximately 2005, and presents the results of a 2018 ‐ 2019 survey with 250 judicial educators on the topics of trauma education for the judiciary and preferred teaching models. Results suggest that trauma is and will likely remain an important topic in judicial education for the foreseeable future. Further, results indicate that there are some common criticisms about current trauma education that should be considered in curriculum design and delivery, and that there is a general preference for team teaching approaches that include a strong peer‐to‐peer discussion component. Recommendations and considerations for judicial educators on the topic of trauma are also presented.
The protective effects of Kava (Piper Methysticum) constituents in cancers: A systematic review
Authors: Celentano Antonio , Tran Andrew , Testa Claire , Thayanantha Krishen , Tan‐Orders William , Tan Stephanie , Syamal Mitali , McCullough Michael J. , Yap Tami 
Published: June 2019

AbstractBackgroundKava is a beverage made from the ground roots of the plant Piper Methysticum and has long‐held a significant place within Pacific island communities. Active compounds were extracted from kava, and secondary metabolites include kavalactones, chalcones, cinnamic acid derivatives and flavanones. It is thought that components of kava may exert an antiproliferative effect through cell cycle arrest and promotion of apoptosis.MethodsWe conducted a systematic review to summarize available evidence of the anticancer effects of kava components and investigate their potential use for oral squamous cell carcinoma (OSCC) treatment. Eligible studies were identified through a comprehensive search of OVID EMBASE, OVID MEDLINE and Web of Science, as at April 2018.ResultsOf 39 papers that met the inclusion criteria, 32 included in vitro models and 13 included animal studies. A total of 26 different cancers were assessed with 32 studies solely assessing epithelial cancers, 6 mesenchymal cancers and 1 study including both. There was only one report assessing an OSCC cell line. Antiproliferative properties were demonstrated in 32 out of 39 papers. The most researched constituent of kava was flavokavain B followed by flavokavain A. Both were associated with increased expression of pro‐apoptotic proteins and decreased expression of anti‐apoptotic proteins. Further, they were associated with a dose‐dependent reduction of angiogenesis.ConclusionThere was heterogeneity of study models and methods of investigation across the studies identified. Components of kava appear to present an area of interest with chemotherapeutic potential in cancer prevention and treatment, particularly for epithelial neoplasms. To date, there is a paucity of literature of the utility of kava components in the prevention and treatment of oral squamous cell carcinoma.