bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of a plant aquaporin by a Casparian strip membrane domain protein‐like
Authors: Champeyroux Chloé , Bellati Jorge , Barberon Marie , Rofidal Valérie , Maurel Christophe , Santoni Véronique 
Published: February 2019

AbstractThe absorption of soil water by roots allows plants to maintain their water status. At the endodermis, water transport can be affected by initial formation of a Casparian strip and further deposition of suberin lamellas and regulated by the function of aquaporins. Four Casparian strip membrane domain protein‐like (CASPL; CASPL1B1, CASPL1B2, CASPL1D1, and CASPL1D2) were previously shown to interact with PIP2;1. The present work shows that CASPL1B1, CASPL1B2, and CASPL1D2 are exclusively expressed in suberized endodermal cells, suggesting a cell‐specific role in suberization and/or water transport regulation. When compared with wild‐type plants, and by contrast to caspl1b1*caspl1b2 double loss of function, caspl1d1*caspl1d2 double mutants showed, in some control or NaCl stress experiments and not upon abscisic acid (ABA) treatment, a weak enlargement of the continuous suberization zone. None of the mutants showed root hydraulic conductivity (Lpr) phenotype, whether in control, NaCl, or ABA treatment conditions. The data suggest a slight negative role for CASPL1D1 and CASPL1D2 in suberization under control or salt stress conditions, with no major impact on whole root transport functions. At the molecular level, CASPL1B1 was able to physically interact with PIP2;1 and potentially could influence the regulation of aquaporins by acting on their phosphorylated form.
Environmental justice screening tools: Implications for nursing
Authors: Amiri Azita , Zhao Shuang 
Published: February 2019

AbstractEnvironmental justice (EJ) means socially and economically disadvantaged communities and citizens are entitled to an equally clean environment and resources to enjoy. EJ communities are mostly located close to polluters such as Superfund sites, coal‐fired power plants and landfills and are more likely to be exposed to higher levels of environmental hazards than the U.S. population on average. It is often a difficult task to identify EJ communities and the environmental hazards in the communities without using specific EJ screening tools. Therefore, the goal of this manuscript is to introduce public health nurses to map‐based EJ screening tools. This will help public health nurses to identify EJ communities and take appropriate actions. Public Health Nurses can also use other relevant web sites, such as the U.S. Environmental Protection Agency (EPA), National Institute of Environmental Health Sciences (NIEHS) and Toxicology Data Network (TOXNET) as resources concerning potential health effects of pollutants. Using the provided tools in this paper, nurses should be able to identify EJ communities and be united to recognize barriers of EJ communities and become promoters for EJ advocacy in practice, leadership and education.
Differential effects of age on quality of sleep and depression in patients receiving maintenance haemodialysis
Authors: Lin Kuan‐Yu , Lin Yi‐Chun , Wang Hsiu‐Ho 
Published: February 2019

BackgroundPoor quality of sleep and depression are common and highly associated with each other in patients on haemodialysis. We aimed to investigate whether they share common risk factors and how age may influence their development.MethodsCross‐sectional observation study on 120 haemodialysis patients with quality of sleep and depression assessed by Pittsburgh Sleep Quality Index (PSQI) and Taiwanese Depression Questionnaire (TDQ), respectively.ResultsThe prevalence of poor quality of sleep and depression was 92.5% and 43.3%, respectively. PSQI scores were associated with age, gender, education and monthly income while TDQ scores were associated with low serum creatinine and albumin levels. Elderly patients at ages older than 65 had the highest average PSQI score (12.26 ± 4.35) than the young group at age 20–44 (8.25 ± 4.39) (P = 0.028) but the average TDQ scores were similar across three age groups. The proportion of those who had high PSQI scores was significantly higher in the elderly group (54.4%, P = 0.017) and the 44–65‐years group (51.9%, P = 0.028) than the young group (16.7%). The proportion of those who reported normal quality of sleep was much lower in the elderly group (0.0%) than the other two groups (25.0%, P < 0.001 and 11.7%, P < 0.01). The proportions of those who had different ranges of TDQ scores did not show such a pattern of strong age dependence.ConclusionsPoor quality of sleep in haemodialysis patients is associated with socio‐economic factors while depression is more related to biochemistry indicators. A majority of older patients suffer very poor quality of sleep while depression appears equally severe and common across different age groups.
When groups help and when groups harm: Origins, developments, and future directions of the “Social Cure” perspective of group dynamics
Authors: Wakefield Juliet R.H. , Bowe Mhairi , Kellezi Blerina , McNamara Niamh , Stevenson Clifford 
Published: February 2019

AbstractA substantial literature supports the important role that social group memberships play in enhancing health. While the processes through which group memberships constitute a “Social Cure” are becoming increasingly well defined, the mechanisms through which these groups contribute to vulnerability and act as a “Social Curse” are less understood. We present an overview of the Social Cure literature and then go beyond this to show how the processes underpinning the health benefits of group membership can also negatively affect individuals through their absence. First, we provide an overview of early Social Cure research. We then describe later research concerning the potential health benefits of identifying with multiple groups, before moving on to consider the “darker side” of the Social Cure by exploring how intra‐group dynamics can foster Curse processes. Finally, we synthesise evidence from both the Cure and Curse literatures to highlight the complex interplay between these phenomena and how they are influenced by both intra‐ and inter‐group processes. We conclude by considering areas we deem vital for future investigation within the discipline.
Instrumental and sensory methodologies to characterize the residual film of topical products applied to skin
Authors: Savary Géraldine , Gilbert Laura , Grisel Michel , Picard Céline 
Published: February 2019

AbstractBackgroundThe work is aimed at the development of a methodology to characterize the tactile properties of topical products during application. Specific attention was paid to the study of the residual properties left at the surface of the skin. This approach was interestingly used to better understand the formulation factors governing the skinfeel of topical preparations.Materials and MethodsCosmetic and pharmaceutical topical products were selected based on their various texture, galenic form (gel or emulsion), and composition (polymer used as texturing agent). Key texture attributes namely Firmness, Stickiness, Spreadability, and Amount of residue were objectively evaluated using sensory analysis. Additionally, texture analysis (compression test), rheology (flow test), and tribology (in vivo friction test) were carried out.ResultsSensory evaluations highlighted a great diversity of tactile properties among products when applied to skin. For example, assessors perceived an important amount of residue left by emulsions whereas gels were not leaving any residue after application to the skin. These results were confirmed by in vivo tactile friction measurements with two distinct evolutions in time of the residual film properties.ConclusionThe present investigation shows how the tactile properties of topical gels and emulsions are studied using complementary tests in order to understand and improve the skinfeel of topical preparations.
Anti‐N and anti‐Doa immunoglobulin G alloantibody–mediated delayed hemolytic transfusion reaction with hyperhemolysis in sickle cell disease treated with eculizumab and HBOC‐201: case report and review of the literature
Authors: Unnikrishnan Athira , Pelletier J. Peter R. , Bari Shahla , Zumberg Marc , Shahmohamadi Abbas , Spiess Bruce D. , Michael Mary Jane , Harris Neil , Harrell Danielle , Mandernach Molly W. 
Published: February 2019

BACKGROUNDDelayed hemolytic transfusion reaction (DHTR) with hyperhemolysis is a potentially fatal complication resulting from alloimmunization that can cause severe hemolysis of both transfused and intrinsic red blood cells (RBCs). Patients with sickle cell disease often receive multiple RBC units during their lifetime and thus are likely to develop alloantibodies that increase the risk for DHTR. Treatment to decrease hemolysis includes intravenous immunoglobulin (IVIG), steroids, eculizumab, rituximab, and plasmapheresis in addition to erythropoietin (EPO), intravenous (IV) iron, vitamin B12, and folate to support erythropoiesis. RBC transfusion is preferably avoided in DHTR due to an increased risk of exacerbating the hemolysis.CASE REPORTWe report a rare case of anti‐N and anti‐Doa immunoglobulin (Ig)G alloantibody–mediated life‐threatening DHTR with hyperhemolysis in a patient with hemoglobin SS after RBC transfusion for acute chest syndrome who was successfully treated with eculizumab and HBOC‐201 (Hemopure) in addition to steroids, IVIG, EPO, IV iron, and vitamin B12. HBOC‐201 (Hemopure) was successfully used as a RBC alternative in this patient.CONCLUSIONAnti‐N and anti‐Doa IgG alloantibodies can rarely cause severe life‐threatening DHTR with hyperhemolysis. HBOC‐201 (Hemopure) can be a lifesaving alternative in this scenario. Our report also supports the use of eculizumab in DHTR; however, prospective studies are needed to determine the appropriate dose and sequence of eculizumab administration.
Biology and management of the invasive weed Ageratina adenophora (Asteraceae): current state of knowledge and future research needs
Authors: Poudel A S , Jha P K , Shrestha B B , Muniappan R 
Published: February 2019

SummaryBiological invasion is increasing worldwide and the management of invasive species is becoming an important priority for vegetation managers. Success of invasive species management depends on a thorough understanding of the biology of the organism in question and the effectiveness of current management efforts, in order to identify the best practices for management improvement. In this review, we synthesised current biological knowledge of a noxious invasive weed Ageratina adenophora to identify knowledge gaps and assessed management efforts to identify best practices. Finally, we proposed some priority areas for future research to fill knowledge gaps and improve management. Our analysis showed that A. adenophora has already invaded 40 countries, mainly in Asia, Oceania, Africa and Europe. Phenotypic plasticity, allelopathic interference and invasion‐mediated changes in the soil microbial community are the proposed mechanisms that facilitate rapid spread of this weed. However, allelopathy as a mechanism of invasion success of this weed has not been supported by ecologically meaningful experiments. Though mechanical, chemical and biological control measures have been used, their success remains limited and the weed continues to spread in new regions. Among seven biological control agents examined to date, gall fly (Procecidochares utilis) and leaf spot fungus (Passalora ageratinae) have been effective in limited areas to suppress growth of this weed. Some perennial native grasses (e.g. Setaria sphacellata and Lolium perenne) have shown potential to competitively suppress A. adenophora. In conclusion, understanding the invasion mechanisms, exploring further to identify effective biological control agents, combined with approaches of ecological restoration, could help in the management of this weed.
Involvement of the Na+,K+‐ATPase isoforms in control of cerebral perfusion
Authors: Staehr Christian , Rajanathan Rajkumar , Matchkov Vladimir V. 
Published: February 2019

New Findings
What is the topic of this review?
In this review, we consider the role of the Na+,K+‐ATPase in cerebrovascular function and how it might be changed in familial hemiplegic migraine type 2 (FHM2). The primary focus is involvement of the Na+,K+‐ATPase isoforms in regulation of cerebrovascular tone.
What advances does it highlight?
In this review, we discuss three overall distinct mechanisms whereby the Na+,K+‐ATPase might be capable of regulating cerebrovascular tone. Furthermore, we discuss how changes in the Na+,K+‐ATPase in cerebral arteries might affect brain perfusion and thereby be involved in the pathology of FHM2.

AbstractFamilial hemiplegic migraine type 2 (FHM2) has been characterized by biphasic changes in cerebral blood flow during a migraine attack, with initial hypoperfusion followed by abnormal hyperperfusion of the affected hemisphere. We suggested that FHM2‐associated loss‐of‐function mutation(s) in the Na+,K+‐ATPase α2 isoform might be responsible for these biphasic changes in several ways. We found that reduced expression of the α2 isoform leads to sensitization of the contractile machinery to [Ca2+]i via Src kinase‐dependent signal transduction. This change in sensitivity might be the underlying mechanism for both abnormally potentiated vasoconstriction and exaggerated vasorelaxation. Moreover, the functional significance of the Na+,K+‐ATPase α2 isoform in astrocytes provides for the possibility of elevated extracellular potassium signalling from astrocytic endfeet to the vascular wall in neurovascular coupling.
Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma
Authors: Mohan Dipika R. , Lerario Antonio Marcondes , Else Tobias , Mukherjee Bhramar , Almeida Madson Q. , Vinco Michelle , Rege Juilee , Mariani Beatriz M. P. , Zerbini Maria Claudia N. , Mendonca Berenice B. , Latronico Ana Claudia , Marie Suely K. N. , Rainey William E. , Giordano Thomas J. , Fragoso Maria Candida B. V. , Hammer Gary D. 
Published: February 2019

Abstract

Purpose:
Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with few therapies; however, patients with locoregional disease have variable outcomes. The Cancer Genome Atlas project on ACC (ACC-TCGA) identified that cancers of patients with homogeneously rapidly recurrent or fatal disease bear a unique CpG island hypermethylation phenotype, “CIMP-high.” We sought to identify a biomarker that faithfully captures this subgroup.
Experimental Design: We analyzed ACC-TCGA data to characterize differentially regulated biological processes, and identify a biomarker that is methylated and silenced exclusively in CIMP-high ACC. In an independent cohort of 114 adrenocortical tumors (80 treatment-naive primary ACC, 22 adrenocortical adenomas, and 12 non-naive/nonprimary ACC), we evaluated biomarker methylation by a restriction digest/qPCR-based approach, validated by targeted bisulfite sequencing. We evaluated expression of this biomarker and additional prognostic markers by qPCR.

Results:
We show that CIMP-high ACC is characterized by upregulation of cell cycle and DNA damage response programs, and identify that hypermethylation and silencing of G0S2 distinguishes this subgroup. We confirmed G0S2 hypermethylation and silencing is exclusive to 40% of ACC, and independently predicts shorter disease-free and overall survival (median 14 and 17 months, respectively). Finally, G0S2 methylation combined with validated molecular markers (BUB1B-PINK1) stratifies ACC into three groups, with uniformly favorable, intermediate, and uniformly dismal outcomes.

Conclusions:
G0S2 hypermethylation is a hallmark of rapidly recurrent or fatal ACC, amenable to targeted assessment using routine molecular diagnostics. Assessing G0S2 methylation is straightforward, feasible for clinical decision-making, and will enable the direction of efficacious adjuvant therapies for patients with aggressive ACC.
PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition
Authors: Sambandam Vaishnavi , Frederick Mitchell J. , Shen Li , Tong Pan , Rao Xiayu , Peng Shaohua , Singh Ratnakar , Mazumdar Tuhina , Huang Chenfei , Li Qiuli , Pickering Curtis R. , Myers Jeffery N. , Wang Jing , Johnson Faye M. 
Published: February 2019

Abstract

Purpose:
Head and neck squamous cell carcinoma (HNSCC) is driven largely by the loss of tumor suppressor genes, including NOTCH1, but lacks a biomarker-driven targeted therapy. Although the PI3K/mTOR pathway is frequently altered in HNSCC, the disease has modest clinical response rates to PI3K/mTOR inhibitors and lacks validated biomarkers of response. We tested the hypothesis that an unbiased pharmacogenomics approach to PI3K/mTOR pathway inhibitors would identify novel, clinically relevant molecular vulnerabilities in HNSCC with loss of tumor suppressor function.
Experimental Design: We assessed the degree to which responses to PI3K/mTOR inhibitors are associated with gene mutations in 59 HNSCC cell lines. Apoptosis in drug-sensitive cell lines was confirmed in vitro and in vivo. NOTCH1 pathway components and PDK1 were manipulated with drugs, gene editing, knockdown, and overexpression.

Results:
PI3K/mTOR inhibition caused apoptosis and decreased colony numbers in HNSCC cell lines harboring NOTCH1 loss-of-function mutations (NOTCH1MUT) and reduced tumor size in subcutaneous and orthotopic xenograft models. In all cell lines, NOTCH1MUT was strongly associated with sensitivity to six PI3K/mTOR inhibitors. NOTCH1 inhibition or knockout increased NOTCH1WT HNSCC sensitivity to PI3K/mTOR inhibition. PDK1 levels dropped following PI3K/mTOR inhibition in NOTCH1MUT but not NOTCH1WT HNSCC, and PDK1 overexpression rescued apoptosis in NOTCH1MUT cells. PDK1 and AKT inhibitors together caused apoptosis in NOTCH1WT HNSCC but had little effect as single agents.

Conclusions:
Our findings suggest that NOTCH1MUT predicts response to PI3K/mTOR inhibitors, which may lead to the first biomarker-driven targeted therapy for HNSCC, and that targeting PDK1 sensitizes NOTCH1WT HNSCC to PI3K/mTOR pathway inhibitors.
Effects of Arteriovenous Fistula on Blood Pressure in Patients With End‐Stage Renal Disease: A Systematic Meta‐Analysis
Authors: Scholz Sean S. , Vukadinović Davor , Lauder Lucas , Ewen Sebastian , Ukena Christian , Townsend Raymond R. , Wagenpfeil Stefan , Böhm Michael , Mahfoud Felix 
Published: February 2019

Background

Central arteriovenous fistula (
AVF
) creation is under investigation for treatment of severe hypertension. We evaluated the effects of
AVF
for initiation of hemodialysis on systolic, diastolic, and mean arterial blood pressure in patients with end‐stage renal disease.

Methods and Results

Data search included PubMed, Web of Science, and the Cochrane Library. A systematic review and meta‐analysis of peer‐reviewed studies reporting the effects of the creation/ligation of an
AVF
on blood pressure in patients with end‐stage renal disease was performed according to the
PRISMA
(Preferred Reporting Items for Systematic Reviews and Meta‐Analysis),
PRISMA
‐P (PRISMA for systematic review protocols), and ROBINS‐I (Risk of Bias in Non‐Randomized Studies) criteria by the Cochrane Bias Methods Group. All studies in which the results could have been biased by hemodialysis were excluded. A total of 14 trials including 412 patients with end‐stage renal disease (
AVF
creation, n=185;
AVF
ligation, n=227) fulfilled the criteria and were subsequently analyzed. Average blood pressure in patients with no/closed
AVF
was 140.5/77.6 mm Hg with a mean arterial blood pressure of 96.1 mm Hg. Following creation of
AVF
, systolic blood pressure significantly decreased by 8.7 mm Hg (
P
<0.001), diastolic blood pressure by 5.9 mm Hg (
P
<0.001), and mean arterial blood pressure by 6.6 mm Hg (
P
=0.02), whereas after ligation systolic blood pressure increased by 5.2 mm Hg (
P
=0.07), diastolic blood pressure by 3.8 mm Hg (
P
=0.02), and mean arterial blood pressure by 3.7 mm Hg (
P
=0.07) during short‐ to long‐term follow‐up.

Conclusions

Creation of
AVF
significantly decreases blood pressure in patients with end‐stage renal disease, whereas blood pressure tends to increase after ligation. These findings illustrate the hemodynamic consequences of
AVF
which are under investigation for severe hypertension.
The Human Character Types in Ancient India
Authors: Zysk Kenneth 
Published: February 2019

Abstract
This paper is a study of the transmission and assimilation of ideas and motifs in different types of Sanskrit literature in ancient India. I examine the classification of both male and female character types in three different Sanskrit literary genres: Jyotiḥśāstra, Āyurveda and Nāṭyaśāstra. The results of the study indicate that the list of male character types offered in the early Jyotiḥśāstra treatise of Garga (Gārgīyajyotiṣa) dating from the beginning of the Common Era contributed in part to the formulations in Āyurveda and formed the basis of the version in the Nāṭyaśāstra. Early āyurvedic treatises expanded the list and organised the male character types according to the Sāṃkhyan guṇa-theory, and the Nāṭyaśāstra further increased the animal similes of Garga, changed the gender emphasis from male to female, and used Kāmaśāstra as the genre for introducting the catalogue of female character types into dramaturgy.
Buddhist and Śaiva Interactions in the Kali Age
Authors: Bisschop Peter C. 
Published: February 2019

Abstract
In a much-discussed passage of the Kāraṇḍavyūhasūtra it is taught that Avalokiteśvara produced Maheśvara from his forehead. Maheśvara is introduced as a representative of the degenerative Kali age. In this connection, the Kāraṇḍavyūha quotes a doctrinal verse about the worship of the liṅga, which for a long time has been mistakenly attributed to ‘the Skandapurāṇa’, but whose source can now be identified in the Śivadharmaśāstra. After a comparative discussion of this verse in both texts, the article considers the possible broader implications of this quotation, in particular in relation to the question of the origin of the six-syllabled mantra oṃ maṇipadme hūṃ and its Śaiva counterpart oṃ namaḥ śivāya. The article concludes with some observations on distinctive features that characterise Śaiva versus Vaiṣṇava interactions with Buddhism.