bluuebunny/crossref_metadata_2025_split huggingface dataset:
Not Like Everybody Else but We're the Same: Psychosocial Variables Compared Across Diverse Sexual and Gender Identities
Authors: Junkins Eleanor J. , Ogolsky Brian G. , Derringer Jaime 
Published: November 2024

ABSTRACTObjectiveSexual and gender minority (SGM) people are underrepresented in psychological research. Part of the underrepresentation of SGM people likely stems from potential participants' unwillingness to join a study, but more concerningly, researchers exclude data from SGM participants. Furthermore, much of SGM research focuses on existing health disparities and risk factors rather than wellness‐framed and personality research. To fill in this gap, the current study aims to quantify effect sizes of similarities/differences across a broad range of psychosocial measures.MethodApplying the framework of the Gender Similarities Hypothesis, we compare means, variances, and correlations across 34 psychosocial variables between categories of SGM, gender identity, sexual orientation, relationship status, and monogamy (N = 1743). Data was collected online mainly through paid ads on Instagram.ResultsConsistently, we find largely similarities across gender identity, sexual orientation, and relationship structure categories. These results support a general expectation that similarities are more common than differences in normative psychological domains, although clear differences in means and variances exist for specific experiences and outcomes.ConclusionsThis work informs the inclusion of diverse identities in basic psychological research and further speaks to the generalizability of past findings to populations historically underrepresented in psychological science.
The Paradox of Situated Knowledge: Toward an Existential Embedment Theory of Perceptual Truth
Authors: Zhao Shanyang 
Published: November 2024

ABSTRACTTruth is a thorny issue for the sociology of knowledge. In emphasizing social influence on knowledge production, sociologists tend to disavow the objectivity of truth and slide down the slope of the consensus theory and the nihilism of post‐truth. In fighting science denial, on the other hand, sociologists often find themselves aligning with the correspondence theory and the naïve notion of naked truth. The aim of this article is to advance a position that recognizes social influence on knowledge attainment without obviating the objectivity in truth. The key to this argument lies in the concept of existential embedment that unifies objectivity and subjectivity in human struggles for survival and prosperity, from which truth originates and to which truth contributes. Existential embedment also anchors knowledge by providing the foundation for truth validation. Depending on the modalities of knowledge attainment, truth is divided into four types with varying degrees of veridical certitude, each having its own criterion for validity assessment. Knowledge that passes the validation test is accepted as truth within the horizon of the given realm of existential embedment, which may change as the existential activity of the knower changes.
New Scenarios in Liver Transplantation for Hepatocellular Carcinoma
Authors: Mauro Ezequiel , Rodríguez‐Perálvarez Manuel , D'Alessio Antonio , Crespo Gonzalo , Piñero Federico , De Martin Eleonora , Colmenero Jordi , Pinato David James , Forner Alejandro 
Published: November 2024

ABSTRACTBackground and AimsDespite liver transplantation (LT) is considered the optimal treatment for hepatocellular carcinoma (HCC), particularly in patients with impaired liver function, the shortage of donors has forced the application of very restrictive criteria for selecting ideal candidates for whom LT can offer the best outcome. With the evolving LT landscape due to the advent of direct‐acting antivirals (DAAs) and the steady increase in donors, major efforts have been made to expand the transplant eligibility criteria for HCC. In addition, the emergence of immune checkpoint inhibitors (ICIs) for the treatment of HCC, with demonstrated efficacy in earlier stages, has revolutionized the therapeutic approach for these patients, and their integration in the setting of LT is challenging. Management of immunological compromise from ICIs, including the wash‐out period before LT and post‐LT immunosuppression adjustments, is crucial to balance the risk of graft rejection against HCC recurrence. Additionally, the effects of increased immunosuppression on non‐hepatic complications must be understood to prevent them from becoming obstacles to long‐term OS.Methods and ResultsIn this review, we will evaluate the emerging evidence and its implications for the future of LT in HCC. Addressing these novel challenges and opportunities, while integrating the current clinical evidence with predictive algorithms, would ensure a fair balance between individual patient needs and the overall population benefit in the LT system.
A global overview of insect–fern interactions and its ecological trends
Authors: Porto Gabriela Fraga , Anjos Diego V. , Luna Pedro , Del‐Claro Kleber 
Published: November 2024

Summary
Historically, ferns have been described as underutilized by insects. However, studies have shown a diversity of insects interacting with ferns, although the evolutionary and ecological drivers of these interactions are still to be untangled.
To fill these gaps, we compiled more than 100 yr of global data on insect–fern interactions from the literature comprising 374 fern and 649 insect species. With this database we assessed how fern trophic specialization, phylogenetic relationships and climate have shaped their interactions with insects.
Our findings showed that interactions between ferns and insects can be explained by the phylogenetic relations among them. We observed that insect orders part of the Endopterygota clade tend to interact with similar fern species, which might be a result of the inheritance of Endopterygota ancestors probably due to phylogenetic niche conservationism. Under an ecological context, fern specialization increased with temperature, precipitation, and climatic stability. Our results show that climate might be one of the main factors explaining the spatial variation of insect–fern interactions, postulate also supported by the observed phylogenetic clustering of the studied ferns species.
Our study highlights the intricate and multifaceted nature of insect–fern interactions, where evolutionary history and ecological factors converge to shape these relationships.
Benzylurea Protects hPDLFs Against LPS‐Induced Mitochondrial Dysfunction Through MTCH2
Authors: Liu Li , Bai Jing , Wang Jiyun , Fan Junheng , Yin Dong , Chang Hong , Hui Xuancheng , Yang Pengfei 
Published: November 2024

ABSTRACTObjectiveThe aim of this study is to explore the mechanism of benzylurea in the inflammatory injury of human periodontal ligament fibroblasts (hPDLFs).MethodsAn inflammation model of hPDLFs was established using LPS. Nuclear transport of nuclear transcription factor‐κB (NF‐κB), secretion of cytokines, and the morphology and distribution of F‐actin were determined. Mitochondrial function was assessed by measuring mitochondrial membrane potential (MMP), mitochondrial permeability transition pore (mPTP), and reactive oxygen species (ROS) levels. The expression of mitochondrial carrier homolog 2 (MTCH2) and Cytochrome b5 type B (CYB5B) was detected.ResultsBenzylurea alleviated the effects of lipopolysaccharide (LPS) on the proliferation and apoptosis of hPDLFs. It reduced the release of inflammatory cytokines and inhibited NF‐κB nuclear translocation. Benzylurea improved mitochondrial function by regulating MMP and preventing excessive mPTP opening. Furthermore, LPS elevated the expression of MTCH2 and reduced the expression of CYB5B in hPDLFs. However, these effects can be inhibited by benzylurea. The altered expression of MTCH2 directly affected CYB5B expression, the release of inflammatory cytokines, and the activation of nuclear translocation of NF‐κB.ConclusionCYB5B may act as an effector of MTCH2, with benzylurea enhancing mitochondrial function and protecting hPDLFs from LPS‐induced injury through MTCH2.
Automated Detection of Oral Malignant Lesions Using Deep Learning: Scoping Review and Meta‐Analysis
Authors: Di Fede Olga , La Mantia Gaetano , Parola Marco , Maniscalco Laura , Matranga Domenica , Tozzo Pietro , Campisi Giuseppina , Cimino Mario G. C. A. 
Published: November 2024

ABSTRACTObjectiveOral diseases, specifically malignant lesions, are serious global health concerns requiring early diagnosis for effective treatment. In recent years, deep learning (DL) has emerged as a powerful tool for the automated detection and classification of oral lesions. This research, by conducting a scoping review and meta‐analysis, aims to provide an overview of the progress and achievements in the field of automated detection of oral lesions using DL.Materials and MethodsA scoping review was conducted to identify relevant studies published in the last 5 years (2018–2023). A comprehensive search was conducted using several electronic databases, including PubMed, Web of Science, and Scopus.Two reviewers independently assessed the studies for eligibility and extracted data using a standardized form, and a meta‐analysis was conducted to synthesize the findings.ResultsFourteen studies utilizing various DL algorithms were identified and included for the detection and classification of oral lesions from clinical images. Among these, three were included in the meta‐analysis. The estimated pooled sensitivity and specificity were 0.86 (95% confidence interval [CI] = 0.80–0.91) and 0.67 (95% CI = 0.58–0.75), respectively.ConclusionsThe results of meta‐analysis indicate that DL algorithms improve the diagnosis of oral lesions. Future research should develop validated algorithms for automated diagnosis.Trial RegistrationOpen Science Framework (https://osf.io/4n8sm)
Warming and UV Radiation Alleviate the Effect of Virus Infection on the Microalga Emiliania huxleyi
Authors: Fu Qianqian , Huang Ruiping , Li Futian , Beardall John , Hutchins David A. , Liu Jingwen , Gao Kunshan 
Published: November 2024

ABSTRACTThe marine microalga Emiliania huxleyi is widely distributed in the surface oceans and is prone to infection by coccolithoviruses that can terminate its blooms. However, little is known about how global change factors like solar UV radiation (UVR) and ocean warming affect the host‐virus interaction. We grew the microalga at 2 temperature levels with or without the virus in the presence or absence of UVR and investigated the physiological and transcriptional responses. We showed that viral infection noticeably reduced photosynthesis and growth of the alga but was less harmful to its physiology under conditions where UVR influenced viral DNA expression. In the virus‐infected cells, the combination of UVR and warming (+4°C) led to a 13‐fold increase in photosynthetic carbon fixation rate, with warming alone contributing a change of about 5–7‐fold. This was attributed to upregulated expression of genes related to carboxylation and light‐harvesting proteins under the influence of UVR, and to warming‐reduced infectivity. In the absence of UVR, viral infection downregulated the metabolic pathways of photosynthesis and fatty acid degradation. Our results suggest that solar UV exposure in a warming ocean can reduce the severity of viral attack on this ecologically important microalga, potentially prolonging its blooms.
Emerging roles of auxin in plant abiotic stress tolerance
Authors: Salehin Mohammad 
Published: November 2024

AbstractPlants are continuously attacked by several biotic and abiotic factors. Among abiotic factors, heat, cold, drought, and salinity are common stresses. Plants produce several hormones as their main weapon in fightback against these stresses. Among these hormones, the role of auxin is well established in regulating plant growth and development at various scales. However, in recent literature, the important role of auxin in abiotic stress tolerance has emerged. Several auxin signalling and transport mutants exhibit heat, drought, and salinity‐related phenotypes. Among them, auxin‐mediated hypocotyl elongation and root growth in response to increased heat are of importance due to the continuous rise in global temperature. Auxin is also involved in regulating and recruiting specialized metabolites like aliphatic glucosinolate to defend themselves from drought stress. Aliphatic glucosinolate (A‐GLS) regulates guard cell closure using auxin, which is independent of the major abiotic stress hormone abscisic acid. This regulatory mechanism serves as an additional layer of guard cell movement to protect plants from drought. Transferring the aliphatic glucosinolate pathway into non‐brassica plants such as rice and soybean holds the promise to improve drought tolerance. In addition to these, post‐translational modification of auxin signalling components and redistribution of auxin efflux transporters are also playing important roles in drought and salt tolerance and, hence, may be exploited to breed drought‐tolerant crops. Also, reactive oxygen species, along with peptide hormone and auxin signalling, are important in root growth under stress. In conclusion, we summarize recent discoveries that suggest auxin is involved in various abiotic stresses.
A QTL on chromosome 17 identified by Genome‐Wide Association Mapping controls postharvest cold tolerance of Cucurbita pepo L.
Authors: García Alicia , Castro‐Cegrí Alejandro , López Alba , Segura María , Benítez Álvaro , Garrido Dolores , Palma Francisco , Martínez Cecilia , Jamilena Manuel 
Published: November 2024

AbstractThe worldwide cultivated Cucurbita pepo L. is one of the most diverse species in the plant kingdom. In this study, chilling tolerance over a wide range of cultivars was characterized to discover the allelic variants to improving the postharvest quality of the immature fruit during cold storage. For this purpose, fruits from 126 accessions of worldwide origin have been evaluated for weight loss and chilling injury after 3, 7 and 14 days of cold storage, classifying them into tolerant, partially tolerant, and sensitive accessions. To verify this classification, antioxidant capacity and lipid peroxidation (MDA) of contrasting accessions (tolerant vs. sensitive) were assessed. The antioxidant capacity significantly decreased during cold storage in the sensitive accessions, while it was maintained in tolerant accessions. Additionally, the sensitive accessions presented a higher accumulation of MDA during this period. Finally, a GWAS analysis using GBS data available in CuGenDBv2, combined with weight loss percentage data, led to the identification of a candidate QTL located on chromosome 17 that regulates postharvest cold tolerance in zucchini. The region contains four SNPs whose alternative alleles were significantly associated with lower weight loss percentage and chilling injury indices during cold storage. Two SNPs are located in the 3’ UTR region of the gene CpERS1, a gene involved in ethylene perception. The other two SNPs generate missense mutations in the coding region of a Pectin methyl esterase inhibitor gene (CpPMI). The role of this QTL and these variants in chilling tolerance is discussed.
The loss‐of‐function of AtNATA2 enhances AtADC2‐dependent putrescine biosynthesis and priming, improving growth and salinity tolerance in Arabidopsis
Authors: Jasso‐Robles Francisco Ignacio , Aucique‐Perez Carlos Eduardo , Zeljković Sanja Ćavar , Saiz‐Fernández Iñigo , Klimeš Pavel , De Diego Nuria 
Published: November 2024

AbstractPutrescine (Put) is a promising small molecule‐based biostimulant to enhance plant growth and resilience, though its mode of action remains unclear. This study investigated the Put priming effect on Arabidopsis mutant lines (Atadc1, Atadc2, Atnata1, and Atnata2) under control conditions and salinity to understand its role in regulating plant growth.The Atadc2 mutant, characterized by reduced endogenous Put levels, showed insensitivity to Put priming without growth enhancement, which was linked to significant imbalances in nitrogen metabolism, including a high Gln/Glu ratio. Contrarily, the Atnata2 mutant exhibited significant growth improvement and upregulated AtADC2 expression, particularly under Put priming, highlighting these genes' involvement in regulating plant development.Put priming enhanced plant growth by inducing the accumulation of specific polyamines (free, acetylated, conjugated, or bound form) and improving light‐harvesting efficiency, particularly in the Atnata2 line. Our findings suggest that AtNATA2 may negatively regulate Put synthesis and accumulation via AtADC2 in the chloroplast, impacting light harvesting in photosystem II (PSII). Furthermore, the Atadc2 mutant line exhibited upregulated AtADC1 but reduced AcPut levels, pointing to a cross‐regulation among these genes. The regulation by AtNATA2 on AtADC2 and AtADC2 on AtADC1 could be crucial for plant growth and overall stress tolerance by interacting with polyamine catabolism, which shapes the plant metabolic profile under different growth conditions. Understanding the regulatory mechanisms involving crosstalk between AtADC and AtNATA genes in polyamine metabolism and the connection with certain SMBBs like Put can lead to more effective agricultural practices, improving plant growth, nitrogen uptake, and resilience under challenging conditions.
Household exposure to COVID‐19 and life insurance holdings
Authors: Wang Ning 
Published: November 2024

AbstractThe COVID‐19 pandemic has resulted in substantial loss of life and economic disruption, leading to a reevaluation of financial planning strategies. This paper examines the relationship between household exposure to COVID‐19 and their life insurance holdings using data from a nationwide household survey in the US. The results indicate that households diagnosed with COVID‐19 are more likely to own life insurance and hold a larger amount of coverage due to the pandemic, with these effects significantly influenced by the bequest motive. Conversely, hospitalization and the death of family members due to COVID‐19 are negatively correlated with life insurance holdings. The implications can inform household and industry decisions to enhance household financial welfare in response to pandemic risks.
Patient involvement in interdisciplinary bedside rounds from nursing and medical students' perceptions. A Swedish qualitative interview study
Authors: Hordiienko Yelyzaveta , Fagerström Cecilia , Rafnar Finnbogadóttir Hafrún 
Published: November 2024

AbstractBackgroundPatient involvement in the interdisciplinary bedside round (IBR) increases care quality and safety but is influenced and perceived differently by different round participants. Nursing and medical students are still not structurally embedded in the healthcare system, and they participate in interdisciplinary bedside rounds for educational purposes. Thus, the students may give a valuable perspective on patient involvement from the ‘outside view’.AimThis study aimed to describe nursing and medical students' perceptions of patient involvement in IBRs.MethodsThis study has a qualitative design with individual interviews. Eighteen informants were recruited with the help of gatekeepers from two sites in Sweden: a university training health clinic and a county hospital. They participated in one‐to‐one semi‐structured interviews, which were analysed with an inductive qualitative content analysis approach.Ethical Issues and ApprovalThe study has been approved by the Swedish Ethical Review Authority. Informed consent was received from all participants.ResultsThe results yielded five categories. Two sub‐themes and one theme of meaning emerged as a ‘red thread’ across the categories. The theme of meaning was: ‘In hospital rounds, the patient is a respected guest, but with a disadvantaged “alien status” due to the hosts' difficult medical language and unclear routines’. Students perceive patients are not fully involved in IBRs, and the healthcare team controls this involvement due to patients' lack of knowledge and vulnerability, the hectic hospital environment, and complicated medical language. Doctors lead IBRs and encourage or discourage patient involvement and nurses act as patient advocates, supporting their involvement.ConclusionsAccording to nursing and medical students, patients are seldom involved in IBRs due to multiple interaction barriers and despite communicational facilitators. Their involvement depends on healthcare professionals. Further research should investigate other IBRs stakeholders' perspectives on patient involvement in IBRs to facilitate it.
Agroecology for migrant ‘emplacement’ in the left‐behind European countryside
Authors: Cappati Simone , Alonso‐Fradejas Alberto 
Published: November 2024

AbstractWe explore the nexus between the green and demographic transitions in the European Union (EU) through the analysis of the challenges and opportunities that agroecology offers for the settlement and socioeconomic participation of Italian city‐dwellers‐turned agroecological farmers and non‐EU agroecological farmworkers in ageing and marginalised rural areas in Italy. Many such areas in Italy have recently experienced an influx of newcomers, including non‐EU labour migrants, refugees and asylum seekers and Italian city‐dwellers looking for a different lifestyle. Municipalities and NGOs have developed initiatives, like agroecology, for newcomers to participate in local societies while simultaneously contributing to sustainable rural (re)development in the context of the EU Green Deal. We discuss the potential of agroecology for the ‘emplacement’ of diverse groups of newcomers in these unlikely places through the analysis of the interpersonal, cultural, economic and institutional relations between newcomers and long‐time residents, and across different groups of newcomers, in two Italian villages. Our findings suggest that everyday interactions among long‐time residents and newcomers contribute to the emplacement of the latter. The analysed agroecological initiatives show potential for the emplacement of newcomers through their strong ethical stance and aspirations for environmental sustainability and improved life quality. However, short‐term contracts for the non‐EU farmworkers combined with tight economic returns for the Italian agroecological farmers may lead to distributional and procedural injustices, including the hyper‐exploitation of migrant farmworkers in the name of environmental sustainability.
Populist votes, orientations, and the COVID‐19 pandemic in Italy: A latent growth study
Authors: Russo Silvia , Roccato Michele , Cavazza Nicoletta , Cena Lorenzo 
Published: November 2024

AbstractObjectiveWe aimed to predict the trend of populist orientations and votes in Italy before and during the COVID‐19 pandemic.MethodUsing the Consequences of COVID‐19 (COCO) data set (quota sample of the Italian adult population), we conducted a 3.5‐year, seven‐wave longitudinal study, with one wave before the pandemic (June 2019) and six waves during the pandemic (April and October 2020, April and October 2021, and April and October 2022).ResultsTwo latent growth analyses have shown that in the period we considered the degree of populism of the party chosen for the vote decreased linearly; this change was positively associated with the anxiety of the participants. Conversely, populist orientations remained stable.ConclusionThe COVID‐19 pandemic plausibly contributed to a superficial and temporary halt to the long populist wave that hit Italy in the last decades, as demonstrated by the decrease in populist vote choices concomitant with a persistent substrate of populist orientations.