bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Water‐Soluble Rod–Coil Conjugated Block Copolymer for Efficient Humidity Sensor
Authors: Khawas Koomkoom , Daripa Soumili , Kumari Pallavi , Das Santanu , Dey Ratan Kumar , Kuila Biplab Kumar 
Published: July 2019

AbstractIn this report, the preparation of highly water‐soluble rod–coil conjugated block copolymer poly(3‐hexylthiophene)‐b‐polystyrenesulfonic acid (P3HT‐b‐PSSA) is demonstrated using a facile method with its moisture sensing properties. The block copolymer synthesis method comprises Kumada catalyst transfer polymerization and atom transfer radical polymerization from a bifunctional initiator followed by sulfonation of polystyrene using moderate reaction conditions. The polymerization results in the synthesis of well‐defined block copolymers with controllable block length. The successful synthesis of the block copolymer is studied by NMR and FTIR spectroscopy while optical and structural properties of the block copolymer are investigated using UV–vis, photoluminescence spectroscopy, XRD, and FESEM. In water, the block copolymer shows aggregated structure with crystalline core formed by rod‐like P3HT chain with absorption maxima at 558 nm, whereas in solid state the absorption maxima is blue shifted to 548 nm. The proton conductivity of the block copolymer P3HT‐b‐PSSA with ≈91% of PSSA (by weight) is measured from impedance study, and the values for bulk and grain conductivities are 5.25 × 10−4 and 4.66 × 10−6 S cm−1, respectively, at room temperature. The as‐synthesized block copolymer shows a very high water uptake with maximum ≈80% in comparison with its initial weight. The I–V measurement of the device made from block copolymer shows nonlinear, rectifying characteristic and the current increases with increase of relative humidity (RH%). The block copolymer device shows well‐correlated systemic and reversible resistance change with RH both in doped and undoped state. It is believed that the interesting and highly reversible moisture‐sensitive electronic properties of this block copolymer will be useful for the fabrication of moisture‐sensitive polymer‐based flexible electronic devices.
Role of miR‐214 in regulation of β‐catenin and the malignant phenotype of melanoma
Authors: Prabhakar Kirthana , Rodrίguez Carlos I. , Jayanthy Ashika S. , Mikheil Dareen M. , Bhasker Aishwarya Iyer , Perera Ranjan J. , Setaluri Vijayasaradhi 
Published: July 2019

AbstractWnt/β‐catenin signaling plays an important role in melanocyte biology, especially in the early stages of melanocyte transformation and melanomagenesis. β‐catenin, encoded by the gene
CTNNB1, is an intracellular signal transducer of Wnt signaling and activates transcription of genes important for cell proliferation and survival. Wnt/β‐catenin signaling is frequently activated in melanoma through oncogenic mutations of β‐catenin and elevated β‐catenin levels are positively correlated with melanoma aggressiveness. Molecular mechanisms that regulate β‐catenin expression in melanoma are not fully understood. MicroRNA‐214 is known to function as a tumor suppressor by targeting β‐catenin in several types of cancer cells. Here, we investigated the regulation of β‐catenin by miR‐214 and its role in melanoma. We show that β‐catenin mRNA levels are negatively correlated with miR‐214 in melanoma. However, overexpression of miR‐214 paradoxically increased β‐catenin protein levels and promoted malignant properties of melanoma cells including resistance to mitogen‐activated protein kinase inhibitors (MAPKi). RNA‐seq analysis revealed that melanoma cells predominantly express a β‐catenin mRNA isoform lacking miR‐214 target site. Using matched miRNA and mRNA‐seq and bioinformatics analysis, we identified novel miR‐214 targets, ankyrin repeat domain 6 (ANKRD6) and C‐terminal binding protein 1 (CTBP1), that are involved in negative regulation of Wnt signaling. Overexpression of miR‐214 or knockdown of the novel miR‐214 targets, ANKRD6 or CTBP1, increased melanoma cell proliferation, migration, and decreased sensitivity to MAPKi. Our data suggest that in melanoma cells β‐catenin is not regulated by miR‐214 and the functions of miR‐214 in melanoma are mediated partly by regulating proteins involved in attenuation of Wnt/β‐catenin signaling.
Identification of a novel EVC variant in a Han‐Chinese family with Ellis‐van Creveld syndrome
Authors: Huang Xiangjun , Guo Yi , Xu Hongbo , Yang Zhijian , Deng Xiong , Deng Hao , Yuan Lamei 
Published: July 2019

AbstractBackgroundEllis‐van Creveld syndrome (EVC), a very rare genetic skeletal dysplasia, is clinically characterized by a tetrad consisting of chondrodystrophy, polydactyly, ectodermal dysplasia, and cardiac anomalies. The aim of this study was to identify the genetic defect for EVC in a five‐generation consanguineous Han‐Chinese pedigree.MethodsA five‐generation, 12‐member Han‐Chinese pedigree was enrolled in this study. Exome sequencing was applied in the proband to screen potential genetic variant(s), and then Sanger sequencing was used to identify the variant in family members and 200 unrelated ethnicity‐matched controls.ResultsA novel homozygous variant, c.2014C>T, p.(Q672*), in the EvC ciliary complex subunit 1 gene (EVC), was detected in the patient, which was cosegregated with the disease in the family and absent in the controls.ConclusionThe identified novel homozygous EVC variant, c.2014C>T, p.(Q672*), was responsible for EVC in this Han‐Chinese pedigree. The findings in this study extend the EVC mutation spectrum and may provide new insights into EVC causation and diagnosis with implications for genetic counseling and clinical management.
The real‐life management of overactive bladder: Turkish Continence Society multicenter prospective cohort study with short‐term outcome
Authors: Zümrütbas Ali E. , Citgez Sinharib , Acar Ömer , İzol Volkan , Uzun Hakki , Kabay Şahin , Sancak Eyüp B. , Yazıcı Cenk , Erdogan Mehmet S. , Tarcan Tufan , Demirkesen Oktay 
Published: July 2019

AbstractIntroductionTurkish Continence Society aimed to analyze how overactive bladder (OAB) is being managed in routine practice by the urologists in Turkey.Material and methodsFourteen urology departments were randomly selected to represent the whole population in this multicenter study. An online data entry and storage software was created for patient recruitment and data assessment. A survey including demographic data, daily habits, lower urinary tract symptoms, and Turkish‐validated OAB‐V8 and ICIQ‐SF questionnaires were completed by all patients. Second part of the survey, including the questions about clinical evaluation and management of the patient, was completed by the treating physician.ResultsA total of 507 patients (394 female and 113 male) were included. Behavioral therapy was recommended to 73.2% of female and 81.4% of male patients although bladder diary was requested for 59.5% and 52.7% of the female and male patients, respectively. In the first visit, 86.1% of the female and 89.3% of the male patients were given antimuscarinics (P = .431). Antimuscarinic‐related side effects occurred in 94.9% and 88.9% of the female and male patients, respectively (P = .937). However, the rate of medical treatment change due to antimuscarinic‐related side effects was only 1.7% in female and 4.8% in male patients at the end of 4 months.ConclusionsBehavioral therapy and antimuscarinics were the preferred initial treatment modalities of OAB in concordance with the guidelines. Despite guideline recommendations, bladder diaries were not utilized in half of the patients. Insufficient efficacy appeared to be the main reason for treatment modification.
Rayleigh‐wave dispersion analysis using complex‐vector seismic data
Authors: Qiu Xinming , Wang Yun , Wang Chao 
Published: July 2019

ABSTRACTIdentification of different modes of Rayleigh waves is essential in surface‐wave surveys. Multi‐mode Rayleigh waves can provide higher accuracy of the near‐surface structure than the fundamental mode alone. However, some modes or frequencies of Rayleigh waves may be absent in the vertical‐component seismic data. To complement the dispersion information, a method based on complex‐vector seismic data is proposed. We construct the complex vector by setting the radial component and vertical component as the real part and imaginary part, respectively. Then, high‐resolution linear Radon transform is used to obtain the multi‐mode Rayleigh‐wave dispersion image of the complex‐vector seismic data. Based on different dispersion characteristics of the radial and vertical components, the dispersion images of the complex–vector seismic data show better performance against interferences and mode misidentification. Synthetic and field examples demonstrate advantages of the complex‐vector method over the traditional vertical‐component method in spectral bands and dispersion curve mode identification. Therefore, a more robust and accurate near‐surface S‐wave velocity structure can be expected compared to the traditional vertical‐component Rayleigh‐wave method.
Synthesis of multiresponsive β‐cyclodextrin nanocomposite through surface RAFT polymerization for controlled drug delivery
Authors: Hosseinzadeh Hossein , Hosseinzadeh Soleyman , Pashaei Shahryar , Ghorbani Naser , Mazaherpour Rohollah 
Published: July 2019

In this study, a unique magnetic, pH, and thermo‐responsive hydrogel nanocomposite was synthesized via surface reversible addition fragmentation chain transfer (RAFT) copolymerization of acrylic acid (AA) and N‐isopropyl acrylamide (NIPAM) in the presence of magnetic β‐cyclodextrin (β‐CD). The nanocomposite demonstrated a pH‐responsiveness behavior at pHs 3 and 9. Moreover, swelling behaviors of nanocomposite were measured in solutions with various temperatures. Furthermore, the nanocomposites exhibited high swelling capacity by applying an external magnetic field because of the presence of Fe3O4 nanoparticles in the polymer structure. Besides, the doxorubicin (DOX) loading and releasing behaviors of the hydrogel nanocomposites were studied because of the stimuli‐responsive properties of the synthesized carriers. The adsorption of DOX obeyed a pseudo‐second‐order model and fitted well to the Langmuir isotherm model with the maximum adsorption capacity uptake of 291 mg g−1. In conclusion, the hydrogel nanocomposites were found to be as potential nanocarriers for use in controlled release applications.
Cardiovascular risks associated with dipeptidyl peptidase‐4 inhibitors monotherapy compared with other antidiabetes drugs in the Japanese population: A nationwide cohort study
Authors: Komamine Maki , Kajiyama Kazuhiro , Ishiguro Chieko , Uyama Yoshiaki 
Published: July 2019

AbstractPurposeWe evaluated the cardiovascular risk associated with dipeptidyl peptidase‐4 inhibitors (DPP‐4Is) as monotherapy compared with other antidiabetic drugs in Japan.MethodsWe conducted a nationwide cohort study involving 2 716 000 diabetes patients in Japan. New users of any antidiabetic drug as monotherapy between 1 April 2010 and 31 October 2014 were identified. Occurrences of myocardial infarction (MI), heart failure (HF), and stroke requiring hospitalization associated with DPP‐4Is were compared with those associated with biguanides (BGs), sulfonylureas (SUs), or α‐glucosidase inhibitors (α‐GIs). Adjusted hazard ratios (aHRs) for these outcomes were estimated by Cox proportional hazards model. Propensity score standardization was used to control for confounding.ResultsWe identified 1 105 103 patients using DPP‐4Is, 278 280 patients using BGs, 273 449 patients using SUs, and 217 026 patients using α‐GIs. The risks of MI and HF for DPP‐4I users were significantly higher than those for BG users (MI: aHR, 1.48 [95%CI, 1.20‐1.82], HF: aHR, 1.46 [95%CI, 1.31‐1.62]), while significantly lower than those for SU users (MI: aHR, 0.84 [95%CI, 0.72‐0.98], HF: aHR, 0.86 [95%CI, 0.81‐0.92]). The risk of MI for DPP‐4I users was similar to that for α‐GI users, while the risk of HF for DPP‐4I users was slightly higher than for α‐GI users (MI: aHR, 0.98 [95%CI, 0.82‐1.17], HF: aHR, 1.12[95%CI, 1.04‐1.21]).ConclusionsRisk of MI and HF requiring hospitalization associated with DPP‐4Is as monotherapy was significantly higher than BGs, significantly lower than SUs, and similar to α‐GIs.
Intestinal responses of the oriental fruit fly Bactrocera dorsalis (Hendel) after ingestion of an entomopathogenic bacterium strain
Authors: Zeng Tian , Bai Xue , Liu Ya‐Lan , Li Jian‐Fang , Lu Yong‐Yue , Qi Yi‐Xiang 
Published: July 2019

AbstractBACKGROUNDBactrocera dorsalis (Hendel) is the main fruit fly pest of tropical and subtropical countries. The application of insecticides to manage this pest has led to serious resistance problems; therefore, new ways to control B. dorsalis are required. Pathogenic bacteria are sources of biocontrol agents for pest management.RESULTSWe determined that a pathogenic bacterial strain, Serratia marcescens PS‐1, isolated from a moribund striped flea beetle (Phyllotreta striolata), was lethal to B. dorsalis adults following ingestion. Histological analyses revealed that PS‐1 damaged the intestinal epithelium, resulting in cell death within 24 h. We then generated a gut transcriptomic data set using RNA‐Seq at two time points (6 and 24 h) after PS‐1 infection. We found that genes encoding the peritrophic matrix constituent were down‐regulated, whereas genes involved in lipid and glycan metabolism, and renewal of the gut epithelium, along with genes encoding digestive enzymes and stress response factors, were up‐regulated. In addition, 14 cecropin genes were identified and cloned from B. dorsalis. To our knowledge, the number of cecropins identified in the present study is greater than that reported in the insects of earlier studies. Moreover, some of the cecropins identified were significantly down‐regulated after PS‐1 treatment.CONCLUSIONOur findings provide new insights into the insect gut response to pathogenic bacterial invasion and may aid the development of new strategies for the biological control of B. dorsalis. © 2019 Society of Chemical Industry
Selective control of photoassociation of alkaline earth dimers: A theoretical study
Authors: Cheng Junxia , Zhang Hong , Cheng Xinlu , Wu Shenjiang 
Published: July 2019

AbstractThe laser synthesis of alkaline earth dimers (Be2, Mg2, Ca2, Sr2, and Ba2) is investigated by theoretical calculation. Photoassociation based on ab initio calculations is rationalized by Franck‐Condon filtering. The optimal target states of photoassociations have been obtained, which are A1∑+u state for Be2, Mg2, and Ca2, and are B1∑+u state for Sr2 and Ba2, corresponding to vibrational transition bands from X1∑+g to excited state are 0‐1, 0‐7, 0‐10, 0‐13, and 0‐3, respectively. The proposed laser drive transitions to target states are also investigated that range from 350 to 740 nm. By using quantum wave‐packet dynamic methods, we calculated the absorption cross sections of photon energy and yields for the selected states of photoassociation. It show that the most sensitive molecules for quantum selective control of photoassociation are Be2 and Ba2 for alkaline earth dimers. These important parameters will provide a feasible scheme for further experimental researches.
Planarity of ethylene/linear polyene analogues focused on π‐electron holding ability of the components
Authors: Nakamura Taiji , Imanishi Akira , Kudo Takako 
Published: July 2019

AbstractEthylene/polyene analogues composed of heavier group 14 elements, such as silicon and germanium, do not prefer a planar structure. In the repulsion dominant (RD) model of our previous study mainly focusing on the planarity of hexasilabenzene, it was demonstrated that electron repulsion promotes nonplanarization of heavy benzene analogues. In this study, we have investigated a correlation between intramolecular π‐electron transfers (polarization effect) and planarity in various linear unsaturated compounds in order to deepen the RD model. Herein, it was revealed that the ability to hold π‐electrons in the planar molecular structure is characteristic of each element. For example, carbon can hold more than one π‐electron, whereas silicon and germanium cannot tolerate even one π‐electron to keep the planar structure. Thus, π‐accepting substituents on the heavy atom were found to make the heavy ethylenes and linear polyenes planar by controlling the number of π‐electrons on each skeletal atom.
Making social networks more human: A topological approach
Authors: Berry Jonathan W. , Phillips Cynthia A. , Saia Jared 
Published: July 2019

AbstractA key problem in social network analysis is to identify nonhuman interactions. State‐of‐the‐art bot‐detection systems like Botometer train machine‐learning models on user‐specific data. Unfortunately, these methods do not work on data sets in which only topological information is available. In this paper, we propose a new, purely topological approach. Our method removes edges that connect nodes exhibiting strong evidence of non‐human activity from publicly available electronic‐social‐network datasets, including, for example, those in the Stanford Network Analysis Project repository (SNAP). Our methodology is inspired by classic work in evolutionary psychology by Dunbar that posits upper bounds on the total strength of the set of social connections in which a single human can be engaged. We model edge strength with Easley and Kleinberg's topological estimate; label nodes as “violators” if the sum of these edge strengths exceeds a Dunbar‐inspired bound; and then remove the violator‐to‐violator edges. We run our algorithm on multiple social networks and show that our Dunbar‐inspired bound appears to hold for social networks, but not for nonsocial networks. Our cleaning process classifies 0.04% of the nodes of the Twitter‐2010 followers graph as violators, and we find that more than 80% of these violator nodes have Botometer scores of 0.5 or greater. Furthermore, after we remove the roughly 15 million violator‐violator edges from the 1.2‐billion‐edge Twitter‐2010 follower graph, 34% of the violator nodes experience a factor‐of‐two decrease in PageRank. PageRank is a key component of many graph algorithms such as node/edge ranking and graph sparsification. Thus, this artificial inflation would bias algorithmic output, and result in some incorrect decisions based on this output.
Preparation of the Orthorhombic Lix(C2H8N2)yFe2Se2 Superconductor by Amine Exchange Method
Authors: Gao Zhan , Zhu Baichuan , Xu Han‐Shu , Xu Wentao , Luo Qinxin , Tang Kaibin 
Published: July 2019

AbstractA new FeSe‐based superconductor Lix(C2H8N2)yFe2Se2 with Tc=30 K was successfully synthesized by substituting ethylenediamine(en) for ammonia molecules in Lix(NH3)yFe2Se2. The XRD pattern indicates that the intercalation compound is an orthorhombic structure with lattice parameters a=3.8517(7)Å, b=3.9188(7)Å, c=21.4862(6)Å at room temperature, which is different from the tetrahedral phase Lix(C2H8N2)yFe2Se2 with Tc=45 K synthesized by solvothermal method. Compared with the precursor Lix(NH3)yFe2Se2, the Lix(C2H8N2)yFe2Se2 underwent a structure transition from tetrahedral to orthorhombic during the amine exchange reaction accompanying by the decrease of Tc, indicating that Tc is influenced by structure.
Fe3O4@BNPs‐CPTMS‐Chitosan‐Pd(0) as an Efficient and Stable Heterogeneous Magnetic Nanocatalyst for the Chemoselective Oxidation of Alcohols and Homoselective Synthesis of 5‐Subestituted 1H‐Tetrazoles
Authors: Khodamorady Minoo , Bahrami Kiumars 
Published: July 2019

AbstractIn this content, a stable, efficient, active, reusable and inexpensive magnetic boehmite was synthesized by hydrothermal sol‐gel method. In the next step magnetic boehmite immobilized further with palladium chitosan complex (Fe3O4@BNPs‐CPTMS‐Chitosan‐Pd(0)). This novel nanocatalyst was used for the oxidation of alcohols in ethanol and the preparation of 5‐substituted tetrazoles in solvent‐free conditions. To confirm the structure of catalyst, a variety of techniques, including FT‐IR, XRD, FESEM, TEM, EDX, mapping, VSM, TGA‐DTA, BET, ICP and UV‐Visible were used. The mol % of catalyst was obtained with ICP (2.8 mol%). Also, some benefits of the catalyst are: excellent magnetic properties, easy separating from the reaction mixture with the external magnet, the use of cheap and affordable materials, good surface area (55.94 m2/g), low palladium leaching from the catalyst surface, use the green ligand and the use of catalyst for at least 5 consecutive times without reducing the catalytic activity.
Simultaneous Boost of Power Factor and Figure‐of‐Merit in In–Cu Codoped SnTe
Authors: Guo Fengkai , Cui Bo , Geng Huiyuan , Zhang Yang , Wu Haijun , Zhang Qian , Yu Bo , Pennycook Stephen J. , Cai Wei , Sui Jiehe 
Published: July 2019

AbstractSignificantly enhanced thermoelectric performance is achieved for eco‐friendly SnTe by a coorperative effect between a dopant resonant energy level and interstitial defects. By manipulating the band structure through indium doping, the Seebeck coefficient is remarkably improved, leading to an enhanced power factor, with a high level of ≈29 µW cm−1 K−2 at 873 K. Lattice thermal conductivity is sharply reduced, approaching the amorphous limit, through the strong phonon scattering induced by multiple scales of Cu2Te nanoprecipitates, as well as Cu interstitials, leading to a high ZT value of ≈1.55 at 873 K.
In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells
Authors: Ostermann Laura , Ladewig Julia , Müller Franz-Josef , Kesavan Jaideep , Tailor Jignesh , Smith Austin , Brüstle Oliver , Koch Philipp 
Published: July 2019

Abstract
During nervous system development, early neuroepithelial stem (NES) cells with a highly polarized morphology and responsiveness to regionalizing morphogens give rise to radial glia (RG) cells, which generate region-specific neurons. Recently, stable neural cell populations reminiscent of NES cells have been obtained from pluripotent stem cells and the fetal human hindbrain. Here, we explore whether these cell populations, similar to their in vivo counterparts, can give rise to neural stem (NS) cells with RG-like properties and whether region-specific NS cells can be generated from NES cells with different regional identities. In vivo RG cells are thought to form from NES cells with the onset of neurogenesis. Therefore, we cultured NES cells temporarily in differentiating conditions. Upon reinitiation of growth factor treatment, cells were found to enter a developmental stage reflecting major characteristics of RG-like NS cells. These NES cell-derived NS cells exhibited a very similar morphology and marker expression as primary NS cells generated from human fetal tissue, indicating that conversion of NES cells into NS cells recapitulates the developmental progression of early NES cells into RG cells observed in vivo. Importantly, NS cells generated from NES cells with different regional identities exhibited stable region-specific transcription factor expression and generated neurons appropriate for their positional identity. Stem Cells 2019;37:1429–1440
Advanced analytics for detection and diagnosis of false alarms and faults: A real case study
Authors: Pliego Marugán Alberto , García Márquez Fausto Pedro 
Published: July 2019

AbstractOnshore and offshore wind farms require a high level of advanced maintenance. Supervisory control and data acquisition (SCADA) and condition monitoring systems are now being employed, generating large amounts of data. They require robust and flexible approaches to convert dataset into useful information. This paper presents a novel approach based on the correlations of SCADA variables to detect and identify faults and false alarms in wind turbines. A correlation matrix between all the SCADA variables is used for pattern recognition. A new method based on curve fittings is employed for detecting false alarms and abnormal behaviours or faults in the components. The study is done in a real case study, validated with false alarms.