bluuebunny/crossref_metadata_2025_split huggingface dataset:
Event-triggered Hꝏ control for NCS with time-delay and packet losses
Authors: Bai Jing , Wang Ying , Zhao Li-Ying 
Published: August 2019

Abstract
This paper is concerned with the discrete event-triggered dynamic output-feedback ${H}_{\infty }$ control problem for the uncertain networked control system, where the time-varying sampling, network-induced delay and packet losses are taken into account simultaneously. The random packet losses are described via the Bernoulli distribution. And then, the closed-loop system is modelled as an augmented time-delay system with interval time-varying delay. By using the Lyapunov stability theory and the augmented state space method, the sufficient conditions for the asymptotic stability of the closed-loop system are proposed in the form of linear matrix inequalities. At the same time, the design method of the ${H}_{\infty }$ controller is created. Finally, a numerical example is employed to illustrate the effectiveness of the proposed method.
Minimal Boundaries in Tonelli Lagrangian Systems
Authors: Asselle Luca , Benedetti Gabriele , Mazzucchelli Marco 
Published: August 2019

Abstract
We prove several new results concerning action minimizing periodic orbits of Tonelli Lagrangian systems on an oriented closed surface $M$. More specifically, we show that for every energy larger than the maximal energy of a constant orbit and smaller than or equal to the Mañé critical value of the universal abelian cover, the Lagrangian system admits a minimal boundary, that is, a global minimizer of the Lagrangian action on the space of smooth boundaries of open sets of $M$. We also extend the celebrated graph theorem of Mather in this context: in the tangent bundle $\textrm{T} M$, the union of the supports of all lifted minimal boundaries with a given energy projects injectively to the base $M$. Finally, we prove the existence of action minimizing simple periodic orbits on energies just above the Mañé critical value of the universal abelian cover. This provides in particular a class of nonreversible Finsler metrics on the two-sphere possessing infinitely many closed geodesics.
Influenza Vaccine Effectiveness in Preventing Hospitalizations in Older Patients With Chronic Obstructive Pulmonary Disease
Authors: Gershon Andrea S , Chung Hannah , Porter Joan , Campitelli Michael A , Buchan Sarah A , Schwartz Kevin L , Crowcroft Natasha S , Campigotto Aaron , Gubbay Jonathan B , Karnauchow Timothy , Katz Kevin , McGeer Allison J , McNally J Dayre , Richardson David C , Richardson Susan E , Rosella Laura C , Simor Andrew E , Smieja Marek , Zahariadis George , Kwong Jeffrey C 
Published: August 2019

Abstract

Background
Annual influenza immunization is recommended for people with chronic obstructive pulmonary disease (COPD) by all major COPD clinical practice guidelines. We sought to determine the seasonal influenza vaccine effectiveness (VE) against laboratory-confirmed influenza-associated hospitalizations among older adults with COPD.

Methods
We conducted a test-negative study of influenza VE in community-dwelling older adults with COPD in Ontario, Canada using health administrative data and respiratory specimens collected from patients tested for influenza during the 2010–11 to 2015–16 influenza seasons. Influenza vaccination was ascertained from physician and pharmacist billing claims. Multivariable logistic regression was used to estimate the adjusted odds ratio of influenza vaccination in people with, compared to those without, laboratory-confirmed influenza.

Results
Receipt of seasonal influenza vaccine was associated with an adjusted 22% (95% confidence interval [CI], 15%–27%) reduction in laboratory-confirmed influenza-associated hospitalization. Adjustment for potential misclassification of vaccination status increased this to 43% (95% CI, 35%–52%). Vaccine effectiveness was not found to vary by patient- or influenza-related variables.

Conclusions
During the studied influenza seasons, influenza vaccination was at least modestly effective in reducing laboratory-confirmed influenza-associated hospitalizations in people with COPD. The imperfect effectiveness emphasizes the need for better influenza vaccines and other preventive strategies.
Associations Between Restrictive Fluid Management and Renal Function and Tissue Perfusion in Adults With Severe Falciparum Malaria: A Prospective Observational Study
Authors: Ishioka Haruhiko , Plewes Katherine , Pattnaik Rajyabardhan , Kingston Hugh W F , Leopold Stije J , Herdman M Trent , Mahanta Kishore , Mohanty Anita , Dey Chandan , Alam Shamsul , Srinamon Ketsanee , Mohanty Akshaya , Maude Richard J , White Nicholas J , Day Nicholas P J , Hossain Md Amir , Faiz Md Abul , Charunwatthana Prakaykaew , Mohanty Sanjib , Ghose Aniruddha , Dondorp Arjen M 
Published: August 2019

Abstract

Background
Liberal fluid resuscitation has proved harmful in adults with severe malaria, but the level of restriction has not been defined.

Methods
In a prospective observational study in adults with severe falciparum malaria, restrictive fluid management was provided at the discretion of the treating physician. The relationships between the volume of fluid and changes in renal function or tissue perfusion were evaluated.

Results
A total of 154 patients were studied, 41 (26.6%) of whom died. Median total fluid intake during the first 6 and 24 hours from enrollment was 3.3 (interquartile range [IQR], 1.8–5.1) mL/kg per hour and 2.2 (IQR, 1.6–3.2) mL/kg per hour, respectively. Total fluid intake at 6 hours was not correlated with changes in plasma creatinine at 24 hours (n = 116; rs = 0.16; P = .089) or lactate at 6 hours (n = 94; rs = −0.05; P = .660). Development of hypotensive shock or pulmonary edema within 24 hours after enrollment were not related to the volume of fluid administration.

Conclusions
Restrictive fluid management did not worsen kidney function and tissue perfusion in adult patients with severe falciparum malaria. We suggest crystalloid administration of 2–3 mL/kg per hour during the first 24 hours without bolus therapy, unless the patient is hypotensive.
Trends in hospital standardized mortality ratios for stroke in Japan between 2012 and 2016: a retrospective observational study
Authors: Amin Rebeka , Kitazawa Takefumi , Hatakeyama Yosuke , Matsumoto Kunichika , Fujita Shigeru , Seto Kanako , Hasegawa Tomonori 
Published: August 2019

Abstract

Objective
Stroke is one of the leading causes of death and disability, and imposes a major healthcare burden. The aim of this study was to determine the characteristics of hospital standardized mortality ratios (HSMRs) for stroke in Japan for the year 2012–16 to describe the trend.

Design
Retrospective observational study.

Setting
Data from the Japanese administrative database.

Participants
All hospital admissions for stroke were identified from diagnostic procedures combination (DPC) database from 2012 to 2016.

Main Outcome Measures
HSMR was calculated using the actual number of in-hospital deaths and expected deaths. To obtain the expected death number, a logistic regression model was developed to get the coefficient with a number of explanatory variables. Predictive accuracy of the logistic models was assessed using c-index and calibration was evaluated using the Hosmer–Lemeshow test.

Results
A total of 63 084 patients admitted for stroke from January 2012 to December 2016 were analyzed. HSMRs showed declining tendency over these 5 years, suggesting stroke-related mortality has been improving. While the HSMRs varied from year to year, a wide variation was also seen among the different hospitals in Japan. The proportion of hospitals with HSMR less than 100 increased from 41.0% in 2012 to 59.0% in 2016.

Conclusion
This study demonstrated that HSMR can be calculated using DPC data and found wide variation in HSMR of stroke among hospitals in Japan and enabled us to image the trend. By examining these trends, facilities, authorities and provinces can initiate designs that will ultimately lead to an upgraded healthcare delivery system.
Predicting emergency department orders with multilabel machine learning techniques and simulating effects on length of stay
Authors: Hunter-Zinck Haley S , Peck Jordan S , Strout Tania D , Gaehde Stephan A 
Published: August 2019

AbstractObjectiveEmergency departments (EDs) continue to pursue optimal patient flow without sacrificing quality of care. The speed with which a healthcare provider receives pertinent information, such as results from clinical orders, can impact flow. We seek to determine if clinical ordering behavior can be predicted at triage during an ED visit.Materials and MethodsUsing data available during triage, we trained multilabel machine learning classifiers to predict clinical orders placed during an ED visit. We benchmarked 4 classifiers with 2 multilabel learning frameworks that predict orders independently (binary relevance) or simultaneously (random k-labelsets). We evaluated algorithm performance, calculated variable importance, and conducted a simple simulation study to examine the effects of algorithm implementation on length of stay and cost.ResultsAggregate performance across orders was highest when predicting orders independently with a multilayer perceptron (median F1 score = 0.56), but prediction frameworks that simultaneously predict orders for a visit enhanced predictive performance for correlated orders. Visit acuity was the most important predictor for most orders. Simulation results indicated that direct implementation of the model would increase ordering costs (from $21 to $45 per visit) but reduce length of stay (from 158 minutes to 151 minutes) over all visits.DiscussionSimulated implementations of the predictive algorithm decreased length of stay but increased ordering costs. Optimal implementation of these predictions to reduce patient length of stay without incurring additional costs requires more exploration.ConclusionsIt is possible to predict common clinical orders placed during an ED visit with data available at triage.
Effect of supplementation of pelleted hazel (Corylus avellana) leaves on blood antioxidant activity, cellular immune response, and heart beat parameters in sheep1
Authors: Wang Shaopu , Giller Katrin , Hillmann Edna , Marquardt Svenja , Schwarm Angela 
Published: August 2019

Abstract
Hazel leaves (Corylus avellana) fed to sheep resulted in decreased methane emissions without negatively affecting feed intake and were found to have antioxidant properties in vitro. The objective of this study was to evaluate effects of hazel leaves, rich in tannins, on blood antioxidant activity, cellular immune response, and heart beat parameters in sheep. Four experimental pellets were produced by mixing alfalfa and hazel leaves in different proportions, including alfalfa alone as a control, 30% and 60% of hazel leaves, the latter also with 3.8% polyethylene glycol (PEG). Six adult, nonpregnant, nonlactating female sheep (71 ± 5.7 kg of body weight) were allocated to 4 treatments in a 6 × 4 crossover design with four 18-d periods. The diet consisted of experimental pellets and ryegrass-dominated hay (ratio 80% to 20% in dry matter), resulting in hazel leaf proportions of approximately 0%, 25%, and 50% in the total diet. Blood samples were collected at the end of each period to determine plasma total phenol concentration and markers of oxidative status as well as peripheral blood mononuclear cells (PBMC) activation and proliferation response in vitro. Heart rate (HR) and HR variability parameters were measured for 2 consecutive days in each period, during different activities (i.e., eating pellets or hay, or lying). Treatments were compared with multiple comparisons and contrast analysis was used to test for linear and quadratic relations. Compared with control, feeding a high dosage of hazel leaves enhanced (P = 0.006) the plasma total antioxidant capacity, which linearly (P = 0.016) increased with increasing level of hazel leaves in the diet. The total phenol concentration and activities of the antioxidant enzymes superoxide dismutase, catalase, and glutathione reductase in the plasma were not different (P ≥ 0.23) among the treatments; however, the latter slightly increased linearly (P = 0.047) with increasing hazel leaves proportion. No differences were observed in the activation and proliferation of PBMC among treatments. The HR decreased linearly (P ≤ 0.009) during pellet eating and lying and the root mean square of successive differences of interbeat intervals (RMSSD) increased linearly (P = 0.037) when lying with increasing level of hazel leaves in the diet. In conclusion, our findings indicate that hazel leaves are a promising supplement to improve oxidative status with no effect on cellular immune response and cardiac stress level of sheep.
Geostatistical Assessment of Frankliniella schultzei (Thysanoptera: Thripidae) Spatial Distribution in Commercial Watermelon Crops
Authors: Pereira Poliana Silvestre , Sarmento Renato Almeida , Lima Carlos Henrique Oliveira , Pinto Cleovan Barbosa , Silva Gerson Adriano , Dos Santos Gil Rodrigues , Picanço Marcelo Coutinho 
Published: August 2019

Abstract
Spatial distribution studies of insect pests make it possible to determine their colonization and dispersal patterns. Watermelon (Citrullus lanatus (Thunb.) Matsum. et Nakai) is among the most frequently consumed fruits in the world, and the common blossom thrips, Frankliniella schultzei (Trybom) (Thysanoptera: Thripidae), is one of the most important insect pests of this plant. The objective of this study was to determine the spatial distribution of F. schultzei in commercial watermelon crops using geostatistics. The studied F. schultzei populations presented an aggregated distribution. The colonization of thrips began at the borders of the crops, especially in the areas located in the opposite direction to that of the prevailing winds. The highest densities of thrips occurred in crops that had cucurbits in the surrounding areas. When monitoring for F. schultzei populations, greater attention should be given to sampling that part of the crop located in the opposite direction to that of the prevailing winds because this is where colonization begins. Even at low densities, the aggregation points of thrips in the crop should be located and controlled so that they do not cause damage. In sampling programs for F. schultzei, samples should be taken at distances greater than 9 m apart because this is the distance up to which densities of this species show spatial dependence. Planting watermelon crops close to other cucurbits should be avoided, as these alternate hosts may act as a source of infestation by this pest.
A wavenumber-domain iterative approach for 3D imaging of magnetic anomalies and gradients with depth constraints
Authors: Cui Yatong , Guo Lianghui 
Published: August 2019

AbstractThree-dimensional magnetic inversion, based on the least-square and regularization algorithm in the space domain, is an important tool for quantitative interpretation of magnetic data. However, the common 3D inversion approaches usually require great numbers of forward and inversion calculations and cause low efficiency for inverting large-scale data. Three-dimensional imaging is an alternate rapid tool for qualitative and quantitative interpretation of magnetic data. In this paper, we present a wavenumber-domain iterative approach for 3D imaging of magnetic anomalies and gradients, which could increase imaging efficiency and is suitable for rapidly imaging large-scale data. The wavenumber-domain formulas for forward modeling and imaging of total magnetic anomaly, three magnetic components, magnetic gradients and magnetic full-tensor gradients are deduced and provided. A depth-scale factor and the constraints of magnetic interface are included into the imaging formulas to enhance depth resolution. An iterative algorithm is adopted for the imaging to reduce the fitting error and improve the imaging accuracy. Tests on synthetic and real data from the Sichuan basin, China, verified the feasibility of the presented approaches.
Development and Validation of the Adolescent Insomnia Questionnaire
Authors: Bromberg Maggie H , de la Vega Rocio , Law Emily F , Zhou Chuan , Palermo Tonya M 
Published: August 2019

Abstract

Objective
Insomnia is a highly prevalent sleep disorder that is particularly common among adolescents with health conditions. We aimed to develop and validate a brief screening measure of insomnia in adolescents that can be used across clinical and community samples. We hypothesized that we would identify evidence supporting reliability, convergent/discriminant validity, and that we would determine preliminary clinical cutoff scores.

Methods
A team of experts in behavioral sleep medicine developed a 13-item brief screening measure of insomnia in adolescents (Adolescent Insomnia Questionnaire [AIQ]). We evaluated the psychometric properties of the AIQ in a sample of 315 youth (11–18 years old, Mean = 14.90, SD = 2.02; 64% female) who had chronic pain (n = 37), headache (n = 170), insomnia diagnosed by a sleep specialist (n = 22), or were otherwise healthy (n = 86).

Results
Using Exploratory and Confirmatory Factor Analysis, we identified three subscales consistent with major diagnostic criteria of insomnia. As expected, the measure showed strong reliability through high internal consistency (α =.91). We also found strong convergent validity through expected positive relationships between the AIQ and self-report measures of sleep disturbance, and divergent validity via weak relationships with parent-report of snoring. Results of receiver operating characteristic (ROC) identified a clinical cutoff score that may assist in clinical decision making.

Conclusions
We found that the AIQ has sound psychometric properties in a large heterogeneous sample of treatment-seeking youth and youth from the community. The AIQ can quickly screen adolescent insomnia and could address an important clinical need in identifying youth in need of insomnia treatment in pediatric practice settings.
Polymicrobial infection with Kluyvera species secondary to pressure necrosis of the hand, a case report
Authors: Metoyer Garyn T , Huff Scott , Johnson R Michael 
Published: August 2019

AbstractKluyvera is a rare infection in the upper extremity. Originally identified as an opportunistic pathogen, the virulence of Kluyvera has been debated. An elderly male presented with multiple pressure sores after being found down for an unknown time period. A hand abscess bacterial culture grew Kluyvera species as part of a polymicrobial infection. Despite multiple debridements, antibiotics and wound care, his clinical course ultimately was unsatisfactory and eventually fatal.
A national survey of the enteral feeding practices in Canadian neonatal intensive care units
Authors: Xu James Haiyang , Coo Helen , Fucile Sandra , Ng Eugene , Ting Joseph Y , Shah Prakesh S , Dow Kimberly ,   Canadian Neonatal Network Investigators
Published: August 2019

AbstractAimNutrition affects the growth and neurodevelopmental outcomes of preterm infants, yet controversies exist about the optimal enteral feeding regime. The objective of this study was to compare enteral feeding guidelines in Canadian neonatal intensive care units (NICUs).MethodThe research team identified key enteral feeding practices of interest. Canadian Neonatal Network site investigators at 30 Level 3 NICUs were contacted to obtain a copy of their 2016 to 2017 feeding guidelines for infants who weighed less than 1,500 g at birth. Each guideline was reviewed to compare recommendations around the selected feeding practices.ResultsFive of the 30 NICUs did not have a feeding guideline. The other 25 NICUs used 22 different enteral feeding guidelines. The guidelines in 40% of those NICUs recommend commencing minimal enteral nutrition (MEN) within 24 hours of birth and maintaining that same feeding volume for 24 to 96 hours. In 40% of NICUs, the guideline recommended that MEN be initiated at a volume of 5 to 10 mL/kg/day for infants born at &lt;1,000 g. Guidelines in all 25 NICUs recommend the use of bovine-based human milk fortifier (HMF), and in 56% of NICUs, it is recommended that HMF be initiated at a total fluid intake of 100 mL/kg/day. Guidelines in only 16% of NICUs recommended routine gastric residual checks. Donor milk and probiotics are used in 76% and 72% of the 25 NICUs, respectively.ConclusionThis study revealed substantial variability in recommended feeding practices for very low birth weight infants, underscoring the need to establish a national feeding guideline for this vulnerable group.
Bearing the White Man’s Burden: American Empire and the Origin of Public Administration
Authors: Roberts Alasdair 
Published: August 2019

AbstractThere is an overlooked chapter in the history of American public administration: the experiment with colonial administration in the two decades following the Spanish-American War. Several scholars now identified as pioneers of American public administration were actively engaged in this project. They studied European empires closely to determine how the new American dependencies should be governed. This work was guided by beliefs about racial superiority and the duty of civilized nations to improve uncivilized peoples through colonization. This episode of administrative history provides insight into how American academics thought about race and public administration in the early decades of the twentieth century, both overseas and within the United States. It compels a reassessment of our understandings about their commitment to democracy, and about the supposed differences between American and European public administration at that time.
Neural signatures of child cognitive emotion regulation are bolstered by parental social regulation in two cultures
Authors: Myruski Sarah , Birk Samantha , Karasawa Mayumi , Kamikubo Aya , Kazama Midori , Hirabayashi Hidemi , Dennis-Tiwary Tracy 
Published: August 2019

Abstract
Caregiver impact on the efficacy of cognitive emotion regulation (ER; i.e. reappraisal) during childhood is poorly understood, particularly across cultures. We tested the hypothesis that in children from Japan and the USA, a neurocognitive signature of effective reappraisal, the late positive potential (LPP), will be bolstered by cognitive scaffolding by parents, and explored whether the two cultures differed in whether mere physical proximity of parents provides similar benefit. Five-to-seven-year-olds (N = 116; nJapan = 58; nUSA = 58) completed a directed reappraisal task (EEG-recorded) in one of three contexts: (i) parent-scaffolding, (ii) parent-present and (iii) parent-absent. Across cultures, those in the parent-scaffolding group and parent-present group showed effective reappraisal via the LPP relative to those in the parent-absent group. Results suggest that scaffolding is an effective method through which parents in these two cultures buttress child ER, and even parental passive proximity appears to have a meaningful effect on child ER across cultures.