bluuebunny/crossref_metadata_2025_split huggingface dataset:
The A‐B‐C of small‐molecule ABC transport protein modulators: From inhibition to activation—a case study of multidrug resistance‐associated protein 1 (ABCC1)
Authors: Wiese Michael , Stefan Sven Marcel 
Published: April 2019

AbstractSeveral mechanisms of pharmacokinetic, metabolic, and regulatory nature have been elucidated to take part or act in concert in the phenomenon of multidrug resistance (MDR). MDR is characterized by cross‐resistance of cells against chemotherapeutic agents, which are used for treatment of e.g., cancer, bacterial infections, or human immunodeficiency virus (HIV) infections. One group of proteins that combines all three stated aspects—the metabolism and distribution of drugs as well as their own regulation—is adenosine triphosphate‐binding cassette (ABC) transporters. These efflux pumps use the energy of adenosine triphosphate hydrolysis for drug translocation from the membrane and the cytosol to the extracellular space, often with cotransport of a cosubstrate. Multidrug resistance‐associated protein 1 (MRP1, ABCC1) had been discovered as one major key player in cancer‐related MDR. The xenobiotic substrates include anthracyclines, vinca alkaloids, podophyllotoxins, as well as glutathione (GSH)‐adducts of certain cytostatics. Contrary to other transport proteins involved in cancer‐related MDR the activity of MRP1 is related to the GSH content of cells. A modern strategy to overcome MRP1‐associated MDR is besides its inhibition the activation of GSH efflux, enforcing cell death due to cellular stress. In addition, it has recently been found that MRP1 contributes to the β‐amyloid protein clearance in Alzheimer's disease (AD). Collectively, transport activation of MRP1 is of therapeutic value, and furthermore helps to elucidate the transport protein function and the mechanisms behind it. This review is meant to summarize the known concepts of MRP1 activation, which might contribute to a further understanding of MRP1 in particular and ABC transporters in general.
Uncertainty and self‐efficacy in parents of a child with congenital cataract—New implications for clinical practice
Authors: Gyllén Jenny , Magnusson Gunilla , Forsberg Anna 
Published: April 2019

AbstractAimThe aim was an in‐depth exploration of uncertainty and self‐efficacy among parents of a child with congenital cataract by means of two theoretical frameworks to re‐design family care.DesignA directed content analysis in accordance with Hsieh & Shannon, using Mishel's theory of uncertainty and Bandura's self‐efficacy theory.MethodsOpen‐ended, in‐depth interviews were conducted with 23 parents of a child with congenital cataract; six mothers, five fathers and six couples.ResultsIn this novel study, self‐efficacy was interpreted as the ability to balance between uncertainty and acceptance. The performance accomplishment of the child and parents bridges the gap between uncertainty and acceptance by reducing uncertainty, thus constituting the level of self‐efficacy. Setbacks and complications increase uncertainty and reduce self‐efficacy, thus performance accomplishment is a mediator of self‐efficacy, while ability to master uncertainty determines the level of self‐efficacy.
Who to blame: An inquiry into universal factors accounting for output variations in public–private partnership initiatives across geographical locations. Who to be blamed for not meeting performance, innovativeness, and quality outputs?
Authors: Tetteh Alexander Narh , Teye Emmanuel Tetteh , Abosi Beatrice Ayerakwa , Chong Ren 
Published: April 2019

With the current controversy and blame game on output of public–private partnership (PPP) initiatives concerns, we investigate why there may be variations in achieving innovativeness, perceived quality, and performance of PPP initiatives across different geographical locations. For instance, we investigate a scenario where “a private company involved in waste management will perform in country ‘A’ but fails to perform in country ‘B’ given the same assignment and target.” We empirically sampled and make conclusions with 475 respondents from the public sector, private sector, and academia based on a survey inquiry. We adopted the structural equation modeling method using the partial least square for the data analysis.The results show that environmental dynamism causes major variations in desired output of PPP initiatives followed by collaboration capacity, environmental fit, and absorptive capacity, respectively. The findings further show that one partner cannot be blamed entirely for causing the failure of PPP initiative. However, we conclude that because on the basis of our data, environmental dynamism, which is as a result of some governmental activities, depicts the highest effect on output, public partners might be more liable. The findings from this study are an explicit view of PPP technocrats, which makes the conclusions more reliable.
When Less is More: The Impact of the Regulation on Standard Workweek on Labor Productivity in South Korea
Authors: Park WooRam , Park Yoonsoo 
Published: April 2019

AbstractThis paper examines the impact of a workweek reduction policy on the labor productivity of manufacturing plants in Korea. Taking advantage of the stepwise introduction of the standard 40‐hour workweek in Korea, we apply a difference‐in‐differences framework to individual‐level cross‐sectional and plant‐level longitudinal data to examine the impact of the policy on working hours and output, respectively. We find that the policy reduced per‐worker hours but increased per‐worker output, which is robust to various specifications and sample restrictions. The observed increase in per‐worker output is likely to be mediated through the increase in the total factor productivity and the amount of capital stock.
Synthesis and fabrication of highly functionalized Jeffamine antimicrobial polymeric coating
Authors: Jalageri Manohara Dhulappa , Puttaiahgowda Yashoda Malgar , Parambil Ajithkumar Manayan , Varadavenkatesan Thivaharan 
Published: April 2019

A simple, robust, and eco‐friendly technique for the fabrication of functionalized Jeffamine polymer in an aqueous medium is developed. The polymer is prepared by post polymerization modification of Jeffamine ED‐2003 of molecular weight 2000. The structure of the modified polymer was studied in detail using FTIR and NMR (1H and 13C NMR) spectroscopic methods. The thermal properties and degradation of the polymer were examined by DSC and TGA techniques. The polymer exhibited glass transition temperature (Tg) at 115°C. The functionalized polymeric compound showed good antimicrobial activity against gram‐negative bacterium Escherichia coli, a tubercular variant Mycobacterium smegmatis, and gram‐positive bacterium Staphylococcus aureus with a zone of inhibition of 6 to 12, 9, and 5 to 9 mm diameter, respectively. The compound also showed good activity against the fungus, Candida albicans, with a zone of inhibition of 6 to 11 mm diameter. The morphology of the polymer films and interaction of the microbes with functionalized Jeffamine polymer were investigated by using scanning electron microscopy (SEM).
The effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabetes mellitus: A randomized double‐blind clinical trial
Authors: Moravej Aleali Armaghan , Amani Reza , Shahbazian Hajieh , Namjooyan Frough , Latifi Seyed Mahmoud , Cheraghian Bahman 
Published: April 2019

Diabetes mellitus is a metabolic disease that manifested as hyperglycemia due to the defect in secretion or function of insulin. Studies have shown that saffron and its derivatives cause a significant reduction in plasma glucose levels in experimental models. The purpose of this study was to investigate the effect of the saffron extract on fasting plasma glucose (FPG), glycated hemoglobin level (HbA1c), lipid profile, liver enzymes, and renal function tests in type 2 diabetic patients. In this double‐blind randomized clinical trial, 64 type 2 diabetic patients who were on oral anti‐diabetic drugs were examined. Participants received either 15 mg of saffron or placebo capsules (two pills per day) for 3 months. Anthropometric indices, dietary intake, FPG, HbA1c, lipid profiles, liver enzymes (ALT, AST, ALP), and renal function (BUN, Cr.) tests were measured pre and post intervention after 3 months. Independent t test and paired t test were used for data analysis. After 3‐months intervention, mean difference of FPG, Cholesterol, LDL‐c, and LDL/HDL ratio between two groups showed significant reduction(p < 0.0001), but HbA1c, HDL‐C, API, TG showed no significant differences (p > 0.05). In saffron group, FPG, HbA1c, cholesterol, LDL‐c, and LDL/HDL ratio decreased significantly after 3‐months intervention compare with baseline (p < 0.0001).
A case‐study of land–atmosphere coupling during monsoon onset in northern India
Authors: Barton Emma J. , Taylor Christopher M. , Parker Douglas J. , Turner Andrew G. , Belušić Danijel , Böing Steven J. , Brooke Jennifer K. , Harlow R. Chawn , Harris Phil P. , Hunt Kieran , Jayakumar A. , Mitra Ashis K. 
Published: April 2019

AbstractThis article presents a land–atmosphere case‐study for a single day during monsoon onset, incorporating data from a research aircraft, satellite products and model outputs. The unique aircraft observations reveal temperature and humidity contrasts of up to 5 K and 4 g/kg in the planetary boundary layer induced by spatial variations in soil moisture. Both antecedent rain and irrigation were found to be drivers of this atmospheric variability. There is also evidence of soil moisture‐induced mesoscale circulations above some surfaces. This is the first time such responses have been observed in situ over India. Soil moisture‐driven temperature anomalies are larger than those found in previous observational studies in the African Sahel. Moreover, irrigation in the region is extensive, unlike in the Sahel, and has a similar atmospheric effect to antecedent rainfall. This implies that historical changes in irrigation practices are likely to have had an important influence on mesoscale processes within the Indian monsoon. We also examine evidence linking soil moisture and cloud formation. Above wetter soils we observed a suppression of shallow cloud, whilst the initiation of deep convection occurred mostly in areas affected by wet–dry soil moisture boundaries. To investigate the impact of soil moisture heterogeneity on large‐scale wind flow, three model depictions of the day are assessed: the European Centre for Medium‐Range Weather Forecasts ERA‐Interim and ERA5 reanalyses, and a high‐resolution (1.5 km) simulation generated using the Indian National Centre for Medium Range Weather Forecasting regional convection‐permitting Unified Model. We find evidence indicating surface flux uncertainties in the models lead to ∼3.5 hPa anomalies in the monsoon trough. This does affect the simulation of monsoon circulation and rainfall. Better representation of mesoscale land–atmosphere coupling is likely to improve the depiction of convection within weather and climate models over India.
A spatial rank–based multivariate EWMA chart for monitoring process shape matrices
Authors: Huwang Longcheen , Lin Li‐Wei , Yu Cheng‐Ting 
Published: April 2019

AbstractIn this article, we propose a nonparametric EWMA control chart for monitoring the shape matrix of a multivariate process based on a spatial rank test and the exponentially weighted moving average scheme. The proposed control chart is essentially developed using an estimated spatial rank covariance matrix to test the shape matrix of the covariance matrix of multivariate distributions with heavy tails. Based on our simulation studies, the proposed control chart outperforms the only existing nonparametric control chart in many practical out‐of‐control scenarios for monitoring the shape matrix of the covariance matrix of many multivariate processes. Further, we point out the weaknesses of both the nonparametric EWMA control charts for monitoring the shape matrix of multivariate processes in real applications and propose one possible method to overcome these weaknesses. We also use an example from a white wine production process to demonstrate the applicability and implementation of the proposed control chart.
Measurement precision and accuracy of high artificial enrichment 15N and 13C tracer samples
Authors: Mannerheim Neringa , Werner Roland A. , Buchmann Nina 
Published: April 2019

RATIONALEOversaturation of the Faraday cup amplifiers of isotope ratio mass spectrometers when using tracers that are highly enriched in heavier isotopes (up to 99.9%) remains a major bottleneck to obtaining high‐precision measurements. The memory effect plays a key role in reducing tracer sample measurement precision and accuracy. Several sample preparation approaches are known to reduce memory effects and to improve tracer sample measurement precision. However, the potential benefits when using very high enrichment tracer samples (> +1000 mUr) have not been tested.METHODSIn this study, we test how specific sample positioning for measurements and frequent use of natural isotope abundance reference materials within the sequence affects the precision and accuracy of isotopic ratio analyses when using a Flash elemental analyser coupled to a DeltaplusXP isotope ratio mass spectrometer for very high enrichment (> +22000 mUr) 15N tracer sample measurements. Furthermore, we investigate if tracer sample dilution with natural isotope abundance materials reduces memory effects and increases measurement precision and accuracy when measurements of high‐enrichment 15N and 13C biomass tracer samples are conducted.RESULTSFrequent use of natural isotope abundance materials and specific positioning increased 15N tracer sample precision, but it had a negative effect on the precision of quality control substances. 15N and 13C tracer sample dilution improved measurement precision by a maximum of ±0.9 mUr; however, a strong linear relationship between the original and the calculated φ values was found. Highly enriched 15N tracer samples caused a maximum memory effect of 0.11%. High levels of 15N abundance within the samples affected measurement accuracy by an average of 6.7%.CONCLUSIONSWe conclude that highly enriched tracer samples do not require dilution before analysis. Tracer sample precision can be improved by using a specific measurement order of expected isotope abundance and by the frequent use of natural abundance reference materials.
Environmentally‐Friendly Exfoliate and Active Site Self‐Assembly: Thin 2D/2D Heterostructure Amorphous Nickel–Iron Alloy on 2D Materials for Efficient Oxygen Evolution Reaction
Authors: Wang Yuanzhe , Zhou Yanyan , Han Minze , Xi Yaokai , You Huanhuan , Hao Xianfeng , Li Zhiping , Zhou Junshuang , Song Dandan , Wang Dong , Gao Faming 
Published: April 2019

AbstractA class of 2D layered materials exhibits substantial potential for high‐performance electrocatalysts due to high specific surface area, tunable electronic properties, and open 2D channels for fast ion transport. However, liquid‐phase exfoliation always utilizes organic solvents that are harmful to the environment, and the active sites are limited to edge sites. Here, an environmentally friendly exfoliator in aqueous solution is presented without utilizing any toxic or hazardous substance and active site self‐assembly on the inert base of 2D materials. Benefiting from thin 2D/2D heterostructure and strong interfacial coupling, the resultant highly disordered amorphous NiFe/2D materials (Ti3C2 MXene, graphene and MoS2) thin nanosheets exhibit extraordinary electrocatalytic performance toward oxygen evolution reaction (OER) in alkaline media. DFT results further verify the experimental results. The study emphasizes a viable idea to probe efficient electrocatalysts by means of the synergistic effect of environmentally friendly exfoliator in aqueous solution and active site self‐assembly on the inert base of 2D materials which forms the unique thin 2D/2D heterostructure in‐suit. This new type of heterostructure opens up a novel avenue for the rational design of highly efficient 2D materials for electrocatalysis.
Adolescent perceptions of sleep and influences on sleep behaviour: A qualitative study
Authors: Godsell Sarah , White Jo 
Published: April 2019

ABSTRACTIntroductionAdolescent sleep deprivation is a growing public health problem. This qualitative study explores adolescents' perceptions of sleep and sleep behaviour, enhancing the current limited body of qualitative research in this area.MethodsThirty three 13–14 year olds (17 boys and 16 girls) from two schools in England participated in focus group discussions. Qualitative thematic analysis was used to identify and examine patterns emerging from the data.ResultsParticipants understood recommended sleep requirements for their age group and ‘sleep hygiene’ strategies, yet most reported getting insufficient sleep. Both boys and girls acknowledged the influence of peers on sleep behaviour. A common obstacle to sleep was distractions from electronic devices. Gender was identified as influencing behaviour, with boys more likely to report watching videos and gaming and girls reporting being distracted by communicating on their mobile phones. Anxious dependency on phones at night was reported by some girl participants. Parents were considered key ‘sleep messengers’ and rulesetters. A variability in parental involvement in sleep behaviour was identified and can be understood as at least partially related to new challenges posed by adolescent use of electronic devices.ConclusionsFindings highlight the importance of parental and peer involvement in supporting adolescents to secure healthy sleep. Endeavours to bring about sustained changes in adolescent sleep practices should be predicated on the role of parents/carers as sleep enforcers and the impact of peers, as well as responding to the gendered aspects of compromised sleep behaviour.
Emergency Preparedness Plans and Perceptions Among a Sample of United States Childcare Providers
Authors: Leser Kendall A. , Looper-Coats Julie , Roszak Andrew R. 
Published: April 2019

ABSTRACTObjectivesChildren are at increased risk for experiencing negative physical and mental health outcomes as a result of disasters. Millions of children spend their days in childcare centers or in residential family childcare settings. The purpose of this study was to describe childcare providers’ perceived levels of preparedness capabilities and to assess differences in levels of perceived preparedness between different types of childcare providers.MethodsA national convenience sample of childcare center administrators and residential family childcare administrators completed a brief online survey about their preparedness efforts.ResultsOverall, there were few differences in preparedness between childcare centers and residential family childcare providers. However, childcare centers were more likely to report that they had written plans (94.47%) than residential family childcare providers (83.73%) were (χ12=15.62; P<.001). Both types of providers were more likely to report being very prepared/prepared for fires (91.31%) than they were for any other type of emergency (flooding, active shooter, etc.; 45.08% to 79.34%).ConclusionsFuture work should assess how childcare providers respond to and recover from emergencies, as well as explore the types of resources childcare providers need in order to feel comfortable caring for children during such emergency situations. (Disaster Med Public Health Preparedness. 2019;13:704–708)
Thermal forcing and ‘classical’ and ‘ultimate’ regimes of Rayleigh–Bénard convection
Authors: Doering Charles R. 
Published: April 2019

The fundamental challenge to characterize and quantify thermal transport in the strongly nonlinear regime of Rayleigh–Bénard convection – the buoyancy-driven flow of a horizontal layer of fluid heated from below – has perplexed the fluid dynamics community for decades. Rayleigh proposed controlling the temperature of thermally conducting boundaries in order to study the onset of convection, in which case vertical heat transport gauges the system response. Conflicting experimental results for ostensibly similar set-ups have confounded efforts to discriminate between two competing theories for how boundary layers and interior flows interact to determine transport through the convecting layer asymptotically far beyond onset. In a conceptually new approach, Bouillaut, Lepot, Aumaître and Gallet (J. Fluid Mech., vol. 861, 2019, R5) devised a procedure to radiatively heat a portion of the fluid domain bypassing rigid conductive boundaries and allowing for dissociation of thermal and viscous boundary layers. Their experiments reveal a new level of complexity in the problem suggesting that heat transport scaling predictions of both theories may be realized depending on details of the thermal forcing.
STABLE ORDERED UNION ULTRAFILTERS AND cov
Authors: FERNÁNDEZ-BRETÓN DAVID JOSÉ 
Published: April 2019

AbstractA union ultrafilter is an ultrafilter over the finite subsets of ω that has a base of sets of the form ${\text{FU}}\left( X \right)$, where X is an infinite pairwise disjoint family and ${\text{FU}}(X) = \left\{ {\bigcup {F|F} \in [X]^{ < \omega } \setminus \{ \emptyset \} } \right\}$. The existence of these ultrafilters is not provable from the $ZFC$ axioms, but is known to follow from the assumption that ${\text{cov}}\left( \mathcal{M} \right) = \mathfrak{c}$. In this article we obtain various models of $ZFC$ that satisfy the existence of union ultrafilters while at the same time ${\text{cov}}\left( \mathcal{M} \right) = \mathfrak{c}$.
Recovering the unity of theology by means of mariology
Authors: Ciftci Mehmet 
Published: April 2019

AbstractThis paper argues that Western theology has lost a certain intellectual unity by becoming divided between dogmatic theology (or doctrine) and moral theology (or ethics). The history of theological reflection on Mary illustrates this, because it has become confined to dogmatic theology and has hardly ever been discussed in the context of morals. However, mariology can help us to understand the doctrinal foundations that must support any adequate moral theology. By helping us to see how morals depend on dogma, mariology can help us to recover the unity of theology.