bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topic inhaled antibiotic therapy in children with prolonged adenoiditis
Authors: Kirichenko I. M. 
Published: June 2019

Currently the issue of antibiotic resistance is urgent due to the unreasonable prescription of systemic antibiotics in the treatment of the upper respiratory tract infections. Frequent use of systemic antibiotic therapy in childhood leads to disruption of the microbiota and the development of secondary immunodeficiency. Alternative topical antibiotic therapy together with mucolytics allows the antibiotic to penetrate directly to the inflammation site and destroy biofilms. The article outlines the use of thiamphenicol glycinate acetylcysteinate in children with prolonged adenoiditis. In Russia this antibiotic is presented by Fluimucil® IT; it is manufactured in the form of a lyophilisate for both injectable solutions and solutions for inhalations and irrigation of mucous membranes. Thiamphenicol glycinate acetylcysteinate helps to improve the course of the disease, in some cases, to avoid invasive procedures and reduce the use of systemic antibiotics.
Polymethylsiloxane polyhydrate (Enterosgel) in the complex treatment of children of the first year of life with diseases of the digestive system
Authors: Khavkin A. I. , Volynets G. V. 
Published: June 2019

Purpose of the study. Evaluation of the clinical efficacy of polymethylsiloxane polyhydrate (Enterosgel) in the complex treatment of children of the first year of life with diseases of the digestive system.Patients and methods. The authors carried out a retrospective analysis of the clinical course of diseases of the digestive organs of noninfectious etiology, the study included 38 patients of the first year of life (age 0.40 [0.25; 0.58] years; a continuousstudy of patients), who were treated with Enterosgel in the complex treatment. The comparison group consisted of 12 children (age 0.42 [0.25; 0.60] years) with diseases of the digestive organs, who did notreceive Enterosgel in complex treatment. The authors carried out a comparative assessment of the symptoms of intoxication, the nature of the stool, indicators of clinical blood tests and length of stay in the hospital.Results. The patients treated with Enterosgel demonstrated faster relief of intoxication symptoms and stool normalization; the length of hospital stay decreased 2 times, negative changes in blood tests and side effects of the drug were not observed.Conclusion. Complex treatment with Enterosgel of the diseases of the digestive organs in children of the first year of life is accompanied by more rapid relief of pathological symptoms and it reduces stay in the hospital, it is not accompanied by side effects, allowing us to recommend Enterosgel for the complex treatment of children of the first year of life.
A METHOD OF RESECTION AND REPLACEMENT OF THE ABDOMINAL AORTA IN PATIENTS WITH INFRARENAL ABDOMINAL AORTIC ANEURYSMS AND SEVERE COMORBID CORONARY PATHOLOGY
Authors: Zotikov A. E. , Ilyin S. S. , Kharazov A. F. , Maryan D. I. , Kozhanova A. V. 
Published: June 2019

This article presents a clinical observation of a patient with a giant atherosclerotic abdominal aortic aneurysm and comorbid uncorrected coronary artery disease. Taking into account the threat of aneurysm rupture, we have chosena surgical intervention using methods that reduce the risk of cardiovascular events in the perioperative period: the distal-first technique allowed us to reduce the aortic clamping time, and the use of temporary axillofemoral bypass grafting reduced peripheral resistance and stress on myocardium.
FEATURES OF DEBRANCHING TECHNIQUE FOR AORTIC DISSECTIONS AND ANEURYSMS IN THORATIC AND THORACO-ABDOMINAL AORTAS
Authors: Zotikov A. E. , Maryan D. I. , Ilyin S. S. , Kulbak V. A. , Pokrovsky A. V. 
Published: June 2019

This article describes a hybrid surgical technique for high-risk patients with thoraco-abdominal aortic dissections and aneurysms. The technical aspects of the first stage of surgical treatment - visceral and brachiocephalic debranching are described in detail. 17 surgical interventions for chronic dissection and aneurysm in the thoracic and thoracoabdominal aortas were performed at the Vishnevsky National Medical Research Center of Surgery of Ministry of Health of the Russian Federation in the period from 2014 to 2019. In two cases, we observed postoperative pancreatitis after surgical treatment of the abdominal aorta branches, which we managed using conservative therapy. After open surgery, all patients were discharged in a satisfactory condition. The selected technique made it possible to prepare patients for the following stage of treatment - endografting of the aorta - without developing serious complications.
PREVALENCE OF CARDIAC RISK FACTORS IN PATIENTS WITH ABDOMINAL AORTIC ANEURYSM
Authors: Arakelyan V. S. , Jane A. R. , Gidaspov N. A. , Kulichkov P. P. , Bortnikova N. V. 
Published: June 2019

Introduction. According to the literature, 27 to 65 % of patients with abdominal aortic aneurysm also suffer from coronary heart disease. Mortality from coronary heart disease after surgical treatment for abdominal aortic aneurysm according to some data exceeds 20 %.Objective: improvement of results of treatment of patients with combined lesions of coronary arteries and aneurysm of the abdominal aortaSubjects and method. A retrospective analysis of case histories of 100 patients hospitalized in our clinic diagnosed with «abdominal aortic aneurysm» for examination. Of all patients, 37 % were diagnosed with significant coronary artery lesions. The average ejection fraction was 58.2 ± 5.4 %, 13 % of the study diagnosed significant violations of local myocardial contractility. 16 % of patients had previous myocardial infarction, 7 % – a permanent form of atrial fibrillation. 4 % of patients complained of chest pain during exercise. Hypertension was present in 100 % of patients, the average maximum systolic blood pressure was 176 ± 24.5 mmHg.Results. Hospital mortality was 2 % (all patients were non-operated on coronary arteries and had no significant coronary pathology). There were no significant complications (cardiac, neurological, respiratory) in the early postoperative period. The average length of hospital stay was 9.8 ± 1.99 bed days.Conclusions. Determination of cardiac status before surgery for abdominal aortic aneurysm is the most important moment of stratification of the risk of perioperative complications. Coronary angiography in patients with abdominal aortic aneurysm is a mandatory point of diagnosis, allowing to identify cardiac risk factors.
CLINICAL OUTCOMES OF ENDOVASCULAR INTERVENTIONS IN DIABETIC PATIENTS WITH CRITICAL LOWER LIMB ISCHEMIA
Authors: Bondar I. A. 
Published: June 2019

The article describes the features of lower limb vessel lesions in patients with diabetes, modern methods for diagnosing critical lower limb ischemia (CLLI), indications for endovascular interventions, and reviews the clinical outcomes of percutaneous transluminal balloon angioplasty in patients with diabetes. The authors emphasized high efficacy of endovascular operations in CLI in patients with diabetes. The issues of the prevention of CLLI and the treatment of the lower limb vascular diseases in diabetes are discussed.
RIVAROXABAN SAFETY DURING DEEP VEIN THROMBOSIS TREATMENT IN PATIIENTS WITH RELATED DAMAGES OF STOMACH AND DUODENUM
Authors: Shcheglov E. A. , Alontseva N. N. , Guliaeva P. S. 
Published: June 2019

The aimof this study was to assess the risk of use of rivaroxaban, which was associated with gastro-duodenal bleeding in patients with deep venous thrombosis.Methods: an analysis of anticoagulant treatment in 683 patients with deep venous phlebothrombosis. All the patients underwent fiberoptic gastroduodenoscopic procedure prior to the anticoagulant treatment. When erosive-ulcerative lesions were detected, the patients received antisecretory therapy with proton pump inhibitors along with anticoagulant therapy.Results: EGD did not show any only stomach pathology only in 10.7 percent of patients at the time of admission. A symptom-free pathology that became a diagnostic finding was identified in 53.1 percent of patients. Fiberoptic gastroduodenoscopy showed completed bleeding or bleeding that was stopped using endoscopic balloon tamponade with achievement of stable hemostasis in 12.9 patients. 59.1 percent of patients received anti-coagulant therapy with rivaroxaban (Xarelto®). In the presented series of patients with acute deep vein thrombosis, the use of rivopoxaban appeared a safe therapeutic option not only in patients with erosive-ulcerative lesions in the gastroduodenal system, but also in those with endoscopic signs of stopped bleeding (on the top of already administered antisecretory therapy with proton pump inhibitors).
DABIGATRAN AND IDARUZIZUMAB. NEW OPPORTUNITIES FOR IMPROVING PATIENT SAFETY
Authors: Novikova N. A. , Volovchenko A. N. , Parfenov D. A. 
Published: June 2019

The widespread use of new oral anticoagulants in clinical practice requires improving the safety of medication use, i.e. the use of specific reversal agents, if necessary. Idarucizumab, a humanied monoclonal antibody fragment, is the first reversal agent authorized in our country that binds to dabigatran. Its efficacy and safety have been validated in several clinical trials, and its use gains experience in real clinical practice.
ASPECTS OF MULTICOMPONENT THERAPY AND PERIOPERATIVE TACTICS IN A PATIENT WITH ATRIAL FIBRILLATION RECEIVING RIVAROXABAN THERAPY. CLINICAL OBSERVATION
Authors: Zemlyanskaya O. A. , Kropacheva E. S. 
Published: June 2019

The use of modern oral anticoagulants is associated with a significant reduction in the risk of stroke and systemic embolism in patients with atrial fibrillation, and thus with an increase in the life expectancy of patients. That is why multicomponent therapy and perioperative tactics are actual during prolonged anticoagulation, the aspects of which seem to be one of the most difficult from the practical point of view. This clinical observation is an illustration of the management of a patient with atrial fibrillation at high thromboembolic risk who is receiving Rivaroxaban therapy and who has indications for catheter ablation and multicomponent antithrombotic therapy.
CLINICAL CASE OF RESUMPTION OF ANTICOAGULANT THERAPY AFTER IMPLANTATION OF THE AMPLATZER CARDIAC PLUG LEFT ATRIAL APPENDAGE OCCLUDER
Authors: Guchaev R. V. , Pevzner D. V. , Merkulov E. V. , Makeev M. I. , Zhukova N. S. , Shakhnovich R. M. , Vedenikin T. Yu. , Shestakova N. V. 
Published: June 2019

The article demonstrates a clinical case of forced renewal of anticoagulant therapy after the endovascular closure of the left atrial appendage. Patient with atrial fibrillation and high risk of thromboembolic complications and bleeding on the background of warfarin administration and inappropriate INR values had an acute hemorrhagic cerebral blood flow disorder developed. Endovascular closure of the left atrial appendage was performed. However, the thrombosis of the area of the delivery system fastening revealed after 12 months was an indication for the resumption of anticoagulant therapy.The article presents modern data on the use of occluders for closing the left atrial appendage, the frequency of complications and antiplatelet therapy schemes depending on the presence of thrombosis risk factors and bleeding.
DIAGNOSIS OF ANTIPHOSPHOLIPID SYNDROME IN PEOPLE WITH CLINICAL CRITERIA OF THE DISEASE. EXPERIENCE OF A SEPARATE OUTPATIENT CENTER
Authors: Vavilova T. V. , Isaeva L. A. , Grinchenko K. Yu. , Bogatenkova Ju. D. , Sorokoumov V. A. 
Published: June 2019

Antiphospholipid syndrome (APS) is an immune-mediated violation of coagulation, the diagnosis of which requires mandatory laboratory confirmation. Since the clinical manifestations of APS are extremely diverse, various specialists are involved in the diagnostic process – neurology, cardiologists, surgeons, hematologists, endocrinologists, laboratory medicine specialists, etc. So far, it remains an open question what specialist exactly should make the final diagnosis and supervise patient with APS. The experience of a separate diagnostic center shows the distribution of prescriptions and their compliance with the international recommendations. This study also provides data on the frequency of prescribing laboratory tests to confirm APS, which is 1.2% of all coagulation tests. Among the patients with suspected APS on the basis of clinical signs, only 12.2% of the diagnosis was confirmed. Presents the dangers of obtaining false-positive results that should be taken into account when prescribing laboratory tests.
HEPARIN-INDUCED THROMBOCYTOPENIA (REVIEW)
Authors: Vasiliev S. A. , Gorgidze L. A. , Moiseeva T. N. , Al’-Radi L. S. , Zozulya N. I. , Sokolova M. A. , Mazurov A. V. 
Published: June 2019

Heparin-induced thrombocytopenia (HIT) is a serious and potentially life-threatening side effect of heparinotherapy. It is an antibody-mediated process that causes platelet activation, increases the procoagulant characteristics of the blood and, as a result, endangering limbs and life-threatening thrombosis. Venous thrombosis is more common than arterial thrombosis, especially deep vein thrombosis of the lower limbs and pulmonary artery thrombosis. Mortality from complications of heparinotherapy occurs with a frequency of 20–30 % of cases. Diagnosis of HIT is difficult. Such basic symptoms as thrombocytopenia and thrombosis are extremely non-specific and may be present in cancer patients and patients with cardiosurgical pathologies without the impact of heparin. Women are twice as likely to have HIT as men. This review describes pathogenesis, clinical features, modern diagnostic methods, risk factors for the emergence of this formidable complication of heparinotherapy, gives an overview of the most frequent use of drugs for the treatment of HIT, and gives modern clinical recommendations for different groups of patients.
Comparison of different magneto-rheological fluids’ stability
Authors: Vėžys Joris , Dragašius Egidijus , Juzėnas Kazimieras , Korobko Evguenia , Mystkowski Arkadiusz 
Published: June 2019

The purpose of this paper is to compare two different methods for describing the sedimentation in different MRFs. It was decided to obtain electric resistivity of the MR fluid under magnetic field and to measure inductance of the solenoid, which is around the MR fluid, for diagnostic of the sedimentation. The electrical resistivity of the MR fluids and inductivity of the solenoid was measured daily for 11 days for 5 different MR fluids: (Lord MRF-140CG, Lord MRF-122EG, Liquids Research Company MRHCCS4-A and Liquids Research Company MRHCCS4-B and MUDZH-3 made in A. V. Luykov Heat and Mass Transfer Institute, Minsk, BY). These two methods and according procedures are described below.
Práticas judiciárias no campo criminal e a construção das verdades na persecução penal: um debate a partir de Michel Foucault
Authors: Leitão Santos Bruno Cavalcante , França Júnior Francisco de Assis de , Rodrigues Santos Hugo Leonardo 
Published: June 2019

O presente artigo tem como objetivo principal analisar criticamente práticas judiciárias emblemáticas no campo criminal e o seu papel na construção das verdadesque interessam à vigente persecução penal brasileira. Importa-nos discutir, por exemplo, se a exposição de pessoas presas e a busca pela confissão são instrumentos legítimos de um sistema que se anuncia como acusatório. O recorte dessa problemática, tão importante quanto complexa, será estruturado a partir de Michel Foucault, autor cujas escavaçõesconceituais nos permitem observar mais nitidamente as articulações realizadas pelo sistema oficial de controle rumo à manutenção de seu acentuado protagonismo no exercício do poder punitivo. As hipóteses utilizadas no desenvolvimento estão baseadas na ideia de que as midiáticas apresentações de pessoas presas e a busca pela confissão do investigado são elementos fundamentais nesse processo histórico de circularidade autoritária, mantendo-se atualmente circunstâncias absolutamente desrespeitosas de direitos e garantias constitucional e democraticamente estabelecidas.
Furto de gado, ação penal e justiça não estatal: sobre o Nascimento da Ação Penal Pública Condicionada à Representação no Brasil (1860-1899)
Authors: Garro Lucas Ribeiro 
Published: June 2019

O presente trabalho busca responder à seguinte questão:como o surgimento da ação penal pública condicionada à representação no Brasil se relaciona com as práticas de justiça não estatais vinculadas ao crime de furto de gado? Para tanto, buscacompreender o surgimento da ação pública condicionada à representação e sua relação com o crime de furto de gado, tendo por recorte temporal os anos de 1860, ano de nascimento deste crime, e 1899, ano em que esta ação deixa de ser aplicada a este delito. Esta análise levará em consideração o contexto jurídico nacional e o internacional, por meio de uma perspectiva histórico-comparada, contextualizando os discursos sobre esta ação e sobre crime de furto de gado no âmbito dos seus interlocutores nacionais e internacionais. Para tanto foram utilizadas ferramentas metodológicas próprias da história comparada do direito, como a inserção internacional do objeto de estudo para compreender a possível relação entre a ação penal pública condicionada e as práticas de negociação entre as partes. A partir dessas perspectivas, serão analisados os debates parlamentares e doutrinas nacionais e internacionais sobre ação penal. Essas fontes têm revelado que a busca pela “publicização” da justiça penal no Brasil foi marcada por negociações, de forma que as práticas de justiça não estatais foram absorvidas e sobrepostas pela justiça estatal, mas não eliminadas.
Cooperação internacional em matéria de lavagem de dinheiro: da importância do auxílio direto, dos tratados internacionais e os mecanismos de prevenção
Authors: Canestraro Anna Carolina 
Published: June 2019

O presente estudo tem por objetivo trazer uma possível resposta às dificuldades que o contexto da criminalidade global trouxe para a persecução do crime de lavagem de dinheiro em razão de um cada vez mais deficiente controle sobre os fluxos financeiros, em especial no âmbito internacional. Isto é, haveria algum mecanismo à disposição do Estado que o permitiria realizar com mais eficiência e rapidez esse necessário follow the money típico dessa específica criminalidade? Como uma possível resposta elegeu-se aqui a Cooperação Internacional como um importante instrumento de persecução ao crime de lavagem de dinheiro; e, com fundamento nas recomendações do Grupo de Ação Financeira (GAFI), ressalta-se, dentre os mecanismos de cooperação, o auxílio direto como um eficaz e célere mecanismo para acompanhar a dinamicidade que exige a persecução desse crime. E, ao fim, destaca-se a importância da união desses mecanismos de cooperação a métodos preventivos, tais como as Unidades de Inteligência Financeira, para um eficiente combate à essa nova criminalidade.
Moderated effect of teachers’ attitudes to the contribution of technology competencies on TPACK
Authors: Yulisman Hendra , Widodo Ari , Riandi R. , Nurina Cut Intan Evtia 
Published: June 2019

Technological Pedagogical and Content Knowledge (TPACK) can be seen as teacher’s skills and abilities in choosing and using technology effectively. However, information about the teacher’s attitudes contribution to technology competencies and science teacher's TPACK is still limited. Therefore, this study aimed to analyze the relationship between teacher's technology competencies and their TPACK as well as the effect of teacher’s attitudes as a moderating effect on relation between these two variables. This survey research used total sampling technique which involved 88 science teachers from junior high school of Kota Banda Aceh. The instruments consisted of questionnaires and multiple-choice test which were distributed directly to the teachers. The data analysis was performed by using the Partial Least Square approach. The results showed that technology competencies have a positive relation to TPACK; likewise, the teachers’ attitudes in technology integration were able to strengthen the positive relation between technology competency and science teacher’s TPACK. Therefore, teacher's attitude is an important factor should be concerned in improving teacher's TPACK.
The integration of PBL and cooperative script to empower critical thinking skills of biology students
Authors: Boleng Didimus Tanah , Maasawet Elsje Theodora 
Published: June 2019

One of the factors lead to the low critical thingking skill is the implementation of teacher center learning. The purpose of this research was to determine the effect of the implementation of Problem-based Learning integrated with Cooperative Script to students’ critical thinking skills. This quasi-experimental research was done in senior high schools of Samarinda, Indonesia. The design used in this research was nonequivalent pretest - posttest control group design. The sample was the class XI students of natural science. The treatment was done in the odd semester in 2016/2017 academic year. The data analysis used was independent-samples t-test (α = 0.05). The results of the data analysis showed that the tvalue (16.57) > ttable (2.00). The mean value of students’ critical thinking skills in the experimental group was 77.28 which means 62% higher than those who were in the control group (47.60). Thus, it can be concluded that the implementation of Problem-based Learning integrated with Cooperative Script gives the significant effect to the students' critical thinking skills.
Anal Sphincter Function After Hemorrhoidectomy
Authors: Kuzminov A. M. , Fomenko O. Yu. , Mukhin I. A. , Frolov S. A. , Vyshegorodtsev D. V. , Korolik V. Yu. , Minbaev S. T. , Belousova S. V. 
Published: June 2019

Aim.To generalize and present current data on the development of approaches to hemorrhoidectomy, as well as to analyse the function of the rectal closing apparatus after surgery.Key findings.The haemorrhoid disease is one of the most common human diseases and the most common reason for visiting a coloproctologist. In Russia, the prevalence of haemorrhoids amounts to 130–145 people per 1,000 adult population, with its proportion in the structure of colon diseases varying from 34 to 41 %. Minimally invasive methods for treating such conditions have been shown to be effective in patients with 1–3 stage haemorrhoids. However, these methods have shown little value at stage 4 hemorrhoids, largely because they fail to affect all parts of the disease pathogenesis. Thus, hemorrhoidectomy remains to be the “gold standard” for stage 4 hemorrhoids treatment, which is aimed at eliminating the three main vascular collectors. Hemorrhoidectomy is accompanied by the risk of stricture and postoperative anal sphincter failure. In this regard, it is necessary to assess the functional state of the rectal closing apparatus after hemorrhoidectomy. Improving hemorrhoidectomy, for example, by the use of an ultrasonic scalpel, allows the hemorrhoidectomy to be performed without additional sewing of vessels and coagulation, and the injury of the anal sphincter to be minimized.Conclusion. The possibility of injuring the anal sphincter is a serious problem in anal surgery. Anal sphincter incontinence is a serious illness that exacerbates the patients’ social life. Unfortunately, the issue of anal sphincter incontinence after hemorrhoidectomy is under-investigated, resulting in few rehabilitation programs.