bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of a pharmacist-led education and follow-up service on anticoagulation control and safety outcomes at a tertiary hospital in China: a randomised controlled trial
Authors: Liang Jia-Bi , Lao Cheng-Kin , Tian Lin , Yang Ying-Ying , Wu Hui-Min , Tong Henry Hoi-Yee , Chan Alexandre 
Published: October 2019

Abstract

Objectives
This study was designed to evaluate the impact of a pharmacist-led anticoagulation service on international normalised ratio (INR) control and other outcomes among patients receiving warfarin therapy at a tertiary hospital in Zhuhai, China.

Methods
In this randomised controlled trial, adult patients who were newly initiated on warfarin with intended treatment duration of at least 3 months were recruited. Participants were randomly allocated to receive the pharmacist-led education and follow-up service (PEFS) or usual care (UC). Anticoagulation control was calculated as the proportions of time within the target INR range (TTR) and time within the expanded target range (TER).

Key findings
A total of 152 participants (77 in the PEFS group and 75 in the UC group) were included. Within 180 days after hospital discharge, the PEFS group spent more TER than the UC group (54.4% versus 42.0%; P = 0.024), whereas the difference in TTR did not reach statistical significance (35.9% versus 29.5%; P = 0.203). No major bleeding events were observed, and the cumulative incidences of major thromboembolic events (6.5% versus 9.3%) and mortality (1.3% versus 1.3%) were similar between the two groups (P&gt; 0.05). At 30 days postdischarge, the PEFS group had better warfarin knowledge by answering 57.5% of questions correctly, compared with the UC group (43.0%) (P = 0.003).

Conclusions
The PEFS markedly enhanced anticoagulation control and warfarin knowledge but there was room for improvement. The expansion of pharmacists’ clinical role and the development of more effective education and follow-up strategies are warranted to optimise anticoagulation management services in China.
The interaction between microbiome and pig efficiency: A review
Authors: Maltecca Christian , Bergamaschi Matteo , Tiezzi Francesco 
Published: October 2019

AbstractThe existence of genetic control over the abundance of particular taxa and the link of these to energy balance and growth has been documented in model organisms and humans as well as several livestock species. Preliminary evidence of the same mechanisms is currently under investigation in pigs. Future research should expand these results and elicit the extent of genetic control of the gut microbiome population in swine and its relationship with growth efficiency. The quest for a more efficient pig at the interface between the host and its metagenome rests on the central hypothesis that the gut microbiome is an essential component of the variability of growth in all living organisms. Swine do not escape this general rule, and the identification of the significance of the interaction between host and its gut microbiota in the growth process could be a game‐changer in the achievement of sustainable and efficient lean meat production. Standard sampling protocols, sequencing techniques, bioinformatic pipelines and methods of analysis will be paramount for the portability of results across experiments and populations. Likewise, characterizing and accounting for temporal and spatial variability will be a necessary step if microbiome is to be utilized routinely as an aid to selection.
TLR5 is a new reporter for triple‐negative breast cancer indicated by radioimmunoimaging and fluorescent staining
Authors: Shi Dai , Liu Weiwei , Zhao Shanshan , Zhang Chao , Liang Ting , Hou Guihua 
Published: October 2019

AbstractTriple‐negative breast cancer (TNBC) is a highly aggressive tumour that lacks marker for targeted diagnosis. Recently, it was reported that toll‐like receptor 5 (TLR5) was associated with some kind of tumours, especially in TNBC, but whether it could be used as a non‐invasive monitoring target is not fully understood. Here, we established TLR5− 4T1 cell line with lentivirus‐shRNA‐TLR5 knock‐down transfection (with tag GFP, green fluorescent protein, TLR5− 4T1) and control TLR5+ 4T1 cell line with negative control lentivirus transfection. The effect of TLR5 down‐regulation was detected with qPCR and Western blot. 125I‐anti‐TLR5 mAb and control isotype 125I‐IgG were prepared and injected to TLR5+/− 4T1‐bearing mice models, respectively. Whole‐body phosphor‐autoradiography, fluorescence imaging and biodistribution were performed. Furthermore, ex vivo tumour TLR5 expression was proved through immunohistochemistry staining. We found that 125I‐anti‐TLR5 mAb could bind to TLR5+ 4T1 with high affinity and specificity. Whole‐body phosphor‐autoradiography after 125I‐anti‐TLR5 mAb injection showed TLR5+ 4T1 tumour images in 24 hours, more clearly in 48 hours. Radioactivities in tumour tissues were positively related with TLR5 expression. Biodistribution assay showed that 125I‐anti‐TLR5 mAb was mainly metabolized through the liver and kidney, and 125I‐anti‐TLR5 mAb was much more accumulated in TLR5+ 4T1 tumour than TLR5− 4T1. In vivo fluorescence imaging successfully showed tumour tissues clearly both in TLR5+ and TLR5− 4T1 mice compared with lentivirus untreated 4T1 tumour. Immunohistochemistry staining showed that TLR5 expression in tumours was indeed down‐regulated in TLR5− 4T1 mice. Our results indicated that 125I‐antiTLR5 mAb was an ideal agent for non‐invasive imaging of TLR5+ tumours; TLR5 may be as a novel molecular target for TNBC non‐invasive diagnosis.
Screening of depression in overweight and obese pregnant women and its predictors
Authors: Salehi‐Pourmehr Hanieh , Dolatkhah Neda , Gassab‐Abdollahi Nafiseh , Farrin Nazila , Mojtahedi Mandana , Farshbaf‐Khalili Azizeh 
Published: October 2019

AbstractAimThe aim of this study was to investigate the screening result of depression and its predictors in overweight and obese pregnant women in second and third trimester of pregnancy.MethodsThe present cross‐sectional study was carried out on 232 overweight or obese pregnant women older than 18 years in the second and third trimesters of pregnancy. Edinburgh Postnatal Depression Scale questionnaire, the International Physical Activity Questionnaire and the Food Record were used. Independent t‐test, Man–Whitney U, Pearson and Spearman correlation test, independent t‐test, one‐way analysis of variance and, multivariate linear regression were applied for data analysis using spss 21.ResultsThe results of the study showed that the mean (standard deviation) score of depression was 10.1 (4.4), and it was similar in both overweight and obese women (P = 0.784). Median (quartile 25–75) of physical activity was 891.0 (495.0–1336.0) metabolic equivalent of task ‐min/week. The total physical activity in obese women was statistically higher than overweight ones (P = 0.032). In linear regression model, the variables of parity, body mass index, physical activity education, protein, fat, oleic acid, monounsaturated fatty acids, potassium, magnesium, and zinc were the strong predictors of depression, and along with the others explained the 80% of variances.ConclusionConsidering the fact that nearly one‐third of overweight and obese women in the present study were positive for depression screening, it is important to pay attention to strong predictors of depression in these women.
Kikuchi‐Fujimoto disease in children
Authors: Selvanathan Shoba N , Suhumaran Sharline , Sahu Vinay K , Chong Chia Yin , Tan Natalie Woon Hui , Thoon Koh Cheng 
Published: October 2019

AimKikuchi‐Fujimoto disease (KFD) is an important cause of lymphadenitis in children. The primary aim of this study was to investigate the clinical characteristics of children with KFD and to assess the recurrence of this disease.MethodsThis is a retrospective study of patients younger than 18 years old, who were diagnosed with KFD from January 2000 to September 2017 at KK Women's and Children's Hospital. Records of children with a histological diagnosis of KFD from a lymph node biopsy were obtained from the Department of Pathology. Case notes and electronic medical records of the patients were reviewed. Data collected included patient characteristics, symptoms, clinical and laboratory findings, treatment and follow‐up.ResultsA total of 98 patients were identified. There were 52 boys and 46 girls with a median age of 11.2 years old. Recurrence occurred in 12 (12.2%) patients. One patient developed systemic lupus erythematosus 10 years after diagnosis of KFD. Recurrent cases were more likely to be managed as an inpatient and have fever at presentation of their first episode of KFD.ConclusionIn our study, KFD in children had a higher prevalence among boys, and had a recurrence rate of 12.2%, with 1% of patients developing systemic lupus erythematosus. We recommend that patients be followed up for recurrence and advised to monitor for symptoms of recurrence.
Determinants of age‐appropriate breastfeeding, dietary diversity, and consumption of animal source foods among Indonesian children
Authors: Sebayang Susy K. , Dibley Michael J. , Astutik Erni , Efendi Ferry , Kelly Patrick J. , Li Mu 
Published: October 2019

AbstractGlobal child feeding practices remain suboptimal. In this study, we assess the determinants of age‐inappropriate breastfeeding, dietary diversity, and consumption of 3+ types of animal source foods (ASFs) using 11,687 observations from combined data from the Indonesian Demographic Health Survey of 2012 and 2017. We used linear and logistic regression after adjusting for the complex sampling design. Child's age and quality of antenatal care (ANC) were associated with all outcomes. Socio‐economic status and labour force participation were positively associated with higher dietary diversity score, ASF consumption, and age‐inappropriate breastfeeding. More ANC visits and having consultation at ANC were associated with more dietary diversity. Higher women's knowledge level was associated with more dietary diversity and consuming more ASF. Compared with western Indonesia, more children in eastern Indonesia were age‐inappropriately breastfed and had lower dietary diversity. The Indonesian government needs to develop programmes to improve child feeding particularly in eastern Indonesia, focusing on improving dietary diversity and ASF consumption in poorer households and on prolonging breastfeeding in richer households. Women's labour force participation should be encouraged, but programmes for working mothers are also needed to support continued breastfeeding and to express breast milk. ANC and postnatal programmes need improved consultation sessions for child feeding.
Extended cognition, the new mechanists' mutual manipulability criterion, and the challenge of trivial extendedness
Authors: Krickel Beate 
Published: October 2019

ABSTRACTMany authors have turned their attention to the notion of constitution to determine whether the hypothesis of extended cognition (EC) is true. One common strategy is to make sense of constitution in terms of the new mechanists' mutual manipulability (MM) account. In this paper, I will show that MM is insufficient. The Challenge of Trivial Extendedness arises due to the fact that mechanisms for cognitive behaviors are extended in a way that should not count as verifying EC. This challenge can be met by adding a necessary condition: cognitive constituents satisfy MM and they are what I call behavior unspecific.
Clinical, pathological characteristics and outcomes of immunoglobulin A nephropathy patients with different ages
Authors: Wen Qiong , Rong Rong , Zhou Qian , Tang Xueqing , Yang Qiongqiong , Chen Wei , Yu Xueqing 
Published: October 2019

AbstractAimTo determine the clinical and pathological differences in immunoglobulin A (IgA) nephropathy (IgAN) with different ages, and to determine whether age is a risk factor for progression of IgAN.MethodsThis was a single centre retrospective cohort study. Patients with biopsy‐diagnosed primary IgAN were stratified into three groups: young‐aged (14‐29 years), middle‐aged (30‐49 years) and older‐age (≥50 years). The primary outcome was end‐stage renal disease (estimated glomerular filtration rate [eGFR] <15 mL/min/1.73 m2, dialysis or renal transplantation) or doubling of the baseline serum creatinine.ResultsA total of 981 patients were enrolled, including 65 (6.6%) patients in older‐age group, 517 (52.7%) in middle‐aged group and 399 (40.7%) in young‐aged group. The older‐age group had significantly higher levels of serum IgA, cholesterol, triglycerides and creatinine, and a reduced eGFR. In contrast to the young adults who had a higher percentage of crescent formation in glomeruli, the older‐aged patients had more severe chronic pathological changes including global glomerulosclerosis and vascular lesions (p < .01). The cumulative renal survival in the older‐age group was slightly shorter than that in the young adult or middle‐aged group, but not achieving significant (p > .05). The 3‐ and 5‐year renal survival rates were similar among the three groups. A multivariate Cox regression analysis showed that age was not an independent predictor of an unfavourable prognosis.ConclusionThe IgAN patients with aged 50 years or older had different clinical pathological changes as compared with younger patients. However, aging was not found as an independently predictor of renal progression of IgAN. Prolonged follow up is necessary to confirm this trend.
Living with a well‐known stranger: Voices of family members to older persons with frontotemporal dementia
Authors: Tyrrell Marie , Fossum Bjöörn , Skovdahl Kirsti , Religa Dorota , Hillerås Pernilla 
Published: October 2019

AbstractAimTo describe family members' experiences of living with persons with neuropsychiatric symptoms (NPS) related to frontotemporal dementia (FTD).BackgroundThe majority of persons with dementia during the disease trajectory develop NPS. Persons with FTD are likely to develop greater levels of NPS than persons with other types of dementias. Research‐based knowledge regarding family members' experiences of living with persons with FTD and NPS is limited.MethodsNine family members of persons with FTD were interviewed. Interviews commenced with completion of the Neuropsychiatric Inventory (NPI). Upon completion of the NPI, questions were posed from an interview guide where study participants provided in‐depth information about NPS identified. Interview data were analysed using qualitative content analysis.ResultsInterviewed family members highlighted that persons with FTD had developed between four and eight co‐existing NPS. Irritability and disinhibition were the most common NPS, with variations in severity, frequency and distress. From the interview data, two themes emerged: Living with a well‐known stranger and Coping and overstepping social norms.ConclusionsLiving with a well‐known stranger depicted a new co‐existence with a loved one with changes in personality and behaviour, which were not inherent to the person or predictable any more. The presence of NPS can threaten the safety of the person with FTD and their family in real world and on social media. Support offered should focus on the person's physical and psychological needs, not on a diagnosis.Implications for practiceFrom a health care perspective it is important to see the person with FTD and their family as unique individuals with specific needs.
Being of Two Minds (or of One in Two Ways): A New Puzzle for Constitution Views of Personal Identity
Authors: Tzinman Rina 
Published: October 2019

AbstractAccording to constitution views of persons, we are constituted by spatially coinciding human animals. Constitution views face an ‘overpopulation' puzzle: if the animal has my brain, there is another thinker where I am. An influential solution to this problem distinguishes between derivative and non‐derivative property possession: persons non‐derivatively have their personal properties, while inheriting others from their constituters. I will show that this solution raises a new problem, by constructing a puzzle with the absurd result that we instantiate certain properties incompatibly. In setting up the puzzle, I demonstrate the relevance of the bodily awareness and self‐awareness literatures to overpopulation puzzles.
Atypical presentations of congenital hemangiomas: Extending the clinical phenotype
Authors: West Emily S. , Totoraitis Kristin , Yadav Bhupender , Kirkorian Anna Yasmine , Drolet Beth A. , Teng Joyce M. , Smidt Aimee C. , Sugarman Jeffrey L. , Frieden Ilona J. 
Published: October 2019

AbstractBackground/ObjectivesCongenital hemangiomas (CH) are a group of benign vascular tumors that are present at birth and exhibit variable involution during infancy. Congenital hemangiomas that do not involute are typically solitary patch or plaque‐type tumors that grow proportionally with somatic growth. We report a case series of 9 patients with persistent CH, which exhibited uncommon features including segmental involvement, recurrent or severe pain, or growth via volumetric increase in size or apparent increased extent of anatomic involvement over time.MethodsVia retrospective chart review, we included patients with persistent CH and atypical presentations. Available data regarding clinical characteristics, natural history, histopathology, imaging, and genetic tests were collected.ResultsData on 9 patients were collected, including 7 noninvoluting CH and 2 partially involuting CH. Three of the 9 cases had segmental distribution, 6 had apparent growth or clinical evolution, and 4 were symptomatic with pain. One also had marked localized intravascular coagulopathy.ConclusionsOngoing or recurrent pain and large extent of anatomic involvement can be features of CH, albeit uncommon ones, and can pose both diagnostic and management challenges. Tissue genomic studies can offer a novel tool for CH diagnosis.
Should we biopsy melanonychia striata in Asian children? A retrospective observational study
Authors: (Colin) Tan WeiXuan , Wang Ding Yuan , Seghers Amelie C. , Koh Mark J. A. , (Nicholas) Goh Seng Geok , (Joyce) Lee Siong See 
Published: October 2019

AbstractBackground and ObjectivesMelanonychia striata is common in children of darker‐skinned Asian races, while subungual melanoma is extremely rare and it is difficult to make a diagnosis clinically. However, performing nail unit biopsies in children is particularly challenging and can result in permanent nail dystrophy. The aim of this study was to review the clinical and histologic characteristics of melanonychia striata in pediatric patients of Asian descent to aid in the clinical decision regarding nail biopsy.MethodsSixty‐two pediatric patients presenting with melanonychia striata involving single or multiple nails at two tertiary pediatric dermatology clinics in Singapore between 2005 and 2015 were reviewed. Clinical and histopathological data were analyzed, including age at onset, age at presentation, location, color, width, presence of Hutchinson's sign, pseudo‐Hutchinson's sign, nail dystrophy, length of follow‐up, and clinical evolution. Histopathological assessment was performed by three senior dermatopathologists independently for cases that underwent a nail biopsy.ResultsNo cases of subungual melanoma were detected in our series. Solitary melanonychia of the thumbnail with a single uniform color was the most common presentation. Pseudo‐Hutchinson's sign was commonly observed. Consensus in histological diagnosis emerged amongst all three dermatopathologists in only half of the cases biopsied.ConclusionThe occurrence of melanoma in Asian children presenting with melanonychia is extremely rare. We recommend clinical follow‐up and anticipatory guidance for these patients and nail unit biopsy only in the presence of high‐risk clinical features.
Allergic contact dermatitis to phenylephrine eye drops in an infant
Authors: Lokhande Archana J. , Soni Rohini , D'souza Paschal , Yadav Yogender , Goel Rishi 
Published: October 2019

AbstractOphthalmic medications used for diagnostic or therapeutic purposes are common causes of allergic contact dermatitis around the eyes. We report a case of periocular allergic contact dermatitis due to tropicamide and phenylephrine eye drops in a 1‐year‐old infant.
Evaluation of the effect of aroma oil as a bath salt on cognitive function
Authors: Kouzuki Minoru , Kitao Satoshi , Kaju Takeshi , Urakami Katsuya 
Published: October 2019

BackgroundAromatherapy is a non‐pharmacological therapy for the improvement of dementia symptoms. This study aimed to assess the effects of aroma oil as a bath salt on cognitive function, olfactory function and sleep quality.MethodsThis was a randomised controlled trial. Overall, 49 patients were able to provide consent, and 35 were finally analysed (Alzheimer's disease: 10, mild cognitive impairment: 25). The patients were randomly assigned to use 0.1%, 0.5% or 1% aroma bath salt. During daily bathing, bath salt was added to the bath water, and the subjects remained in the bathroom for ≥10 min. The intervention period was 24 weeks, and the observation periods were 4 weeks before and after using the aroma bath salt. We performed the Touch Panel‐type Dementia Assessment Scale (TDAS), the Odour Stick Identification Test for Japanese (OSIT‐J) and the Japanese version of the Pittsburgh Sleep Quality Index (PSQI‐J) five times during the before and after observation periods and after the 12‐week intervention.ResultsThere were no significant changes in the TDAS, OSIT‐J and PSQI‐J scores before and after the intervention in all groups. Moreover, there were no significant differences in the TDAS, OSIT‐J and PSQI‐J scores between the groups before and after the intervention. In the correlation analysis of changes in the TDAS and other tests during the intervention period, significant associations between TDAS and sleep latency and sleep disturbances, which are sub‐items of PSQI‐J, were observed in the use of 0.1% aroma bath salt group.ConclusionsThe use of aroma bath salt was not associated with improvement in cognitive function, olfactory function or sleep quality. However, sleep‐related aspects were associated with changes in cognitive function before and after use of aroma bath salt, which suggested that there is a link between improvements in sleep and that in cognitive function.
A Short Reflection on City Branding and its Controversies
Authors: Hospers Gert‐Jan 
Published: October 2019

AbstractThanks to its conceptual character the paper ‘City Branding: An Effective Assertion of Identity or a Transitory Marketing Trick?' by Kavaratzis and Ashworth (2005) is a classic piece in the area of place branding. The paper has been much cited in the literature, but did it really steer the further development of the field? Nearly fifteen years later, there is still a lot of debate in place branding circles. Taking the paper as a starting point I briefly discuss four controversies in city branding: (1) branding versus marketing; (2) places versus products; (3) policy versus politics; and (4) theory versus practice. I conclude that the complexities surrounding places and their stakeholders asks for more realism, modesty and dialogue in the place branding community.