bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal choroid plexus, hippocampus, and lateral ventricles volumes as markers of treatment‐resistant major depressive disorder
Authors: Bravi Beatrice , Paolini Marco , Maccario Melania , Milano Chiara , Raffaelli Laura , Melloni Elisa Maria Teresa , Zanardi Raffaella , Colombo Cristina , Benedetti Francesco 
Published: November 2024

AimOne‐third of patients with major depressive disorder (MDD) do not achieve full remission and have high relapse rates even after treatment, leading to increased medical costs and reduced quality of life and health status. The possible specificity of treatment‐resistant depression (TRD) neurobiology is still under investigation, with risk factors such as higher inflammatory markers being identified. Given recent findings on the role of choroid plexus (ChP) in neuroinflammation and hippocampus in treatment response, the aim of the present study was to evaluate inflammatory‐ and trophic‐related differences in these regions along with ventricular volumes among patients with treatment‐sensitive depression (TSD), TRD, and healthy controls (HCs).MethodsChP, hippocampal, and ventricular volumes were assessed in 197 patients with MDD and 58 age‐ and sex‐matched HCs. Volumes were estimated using FreeSurfer 7.2. Treatment resistance status was defined as failure to respond to at least two separate antidepressant treatments. Region of interest volumes were then compared among groups.ResultsWe found higher ChP volumes in patients with TRD compared with patients with TSD and HCs. Our results also showed lower hippocampal volumes and higher lateral ventricular volumes in TRD compared with both patients without TRD and HCs.ConclusionsThese findings corroborate the link between TRD and neuroinflammation, as ChP volume could be considered a putative marker of central immune activity. The lack of significant differences in all of the region of interest volumes between patients with TSD and HCs may highlight the specificity of these features to TRD, possibly providing new insights into the specific neurobiological underpinnings of this condition.
Morphological characteristics and molecular phylogeny of ‘Tateyama‐marimo’ (Cladophorales) from Tateyama Town, Toyama Prefecture, Japan: a comparative study with related freshwater algae
Authors: Watanabe Takumi , Tamaoki Daisuke , Karahara Ichirou , Yamazaki Yuji 
Published: November 2024

SUMMARY‘Tateyama‐marimo’ represents a Japanese freshwater alga that is considered to be the same as or closely related to Aegagropilopsis moravica (Cladophorales), which is distributed in the Eurasian Continent. However, morphological and genetic studies on ‘Tateyama‐marimo’ remain limited. This study aimed to elucidate the taxonomic and phylogenetic positions of ‘Tateyama‐marimo’ and Aegagropilopsis moravica based on comparative morphological observations utilizing light and electron microscopy and molecular phylogenetic analysis. The samples were collected from the Tateyama Town, Toyama Prefecture, Japan, where ‘Tateyama‐marimo’ was first recorded. Light microscopy revealed that the morphological characteristics of ‘Tateyama‐marimo’ were generally consistent with those reported for Aegagropilopsis moravica. Transmission electron microscopy of ‘Tateyama‐marimo’ presented a polypyramidal pyrenoid structure surrounded by four or more starch sheaths, indicating the high similarity to the ultrastructure of others of the Cladophorales taxa at the ultrastructure level. Additionally, bilenticular‐ and zonal‐type pyrenoids surrounded by two–three starch sheaths were observed. The 2034 bp nucleotide sequences across 18S and 28S ribosomal DNA exhibited high similarity between ‘Tateyama‐marimo’ and Aegagropilopsis moravica, indicating their monophyletic origin on the molecular phylogenetic tree. Altogether, these results suggested that ‘Tateyama‐marimo’ should not be excluded from being treated as Aegagropilopsis moravica; nevertheless, further taxonomic scrutiny is warranted.
Challenges for staff encountering older people's existential concerns: Swedish first‐line managers' views. A cross‐sectional study
Authors: Sundström Malin , Blomqvist Kerstin , Rämgård Margareta , Edberg Anna‐Karin 
Published: November 2024

AbstractAims and ObjectivesTo describe first‐line managers' (FLMs) views of the challenges faced by staff when encountering older people's existential concerns in home and residential care.Methodological Design and JustificationThis cross‐sectional study uses a combination of qualitative and quantitative methods.Ethical Issues and ApprovalThe study was approved by the Swedish Ethical Review Authority (ref. number 2014/652 ) and followed the guidelines of the Helsinki Declaration.Research MethodsFLMs in home and residential care were randomly selected and invited to participate. A self‐administered questionnaire was distributed online to 467 managers, 136 (29%) of whom completed it.ResultsAbout 80% of the FLMs reported that their staff members sometimes or frequently had conversations with the older people in their care about existential concerns, including the following topics: thoughts and feelings about meaning in life; losses and longing for meaningful relations; death, fears and uncertainty and supporting meaningful everyday life. About 75% of the managers also reported that their staff sometimes or often had conversations about existential concerns with one another. Major hindrances to existential conversations were reportedly cognitive impairment and aphasia among the older people and insecurity and unwillingness among the staff. Most managers (73%) reported that their staff received support when encountering existential concerns, mostly as individual support from managers or registered nurses.Study LimitationsThe main limitation of this study is its low response rate, which is common for digital surveys. Nevertheless, the sample is considered to be representative; therefore, the study holds exploratory value.ConclusionRegular conversations among staff, improved conversational skills and the ability to listen reflect on and perceive older people's perspective and life world are needed when encountering older people's existential concerns. FLMs play a crucial role in emphasising and planning staff support on a regular basis.
The Full‐Length Genomic Sequence of the HLA‐B*39:130 Allele
Authors: Li LiXin , Tian Wei 
Published: November 2024

ABSTRACTHLA‐B*39:130 differs from HLA‐B*39:01:01:01 at codon 214 (ACA → ATA) and position 355 (T → C) in intron 5.
The HLA‐A Allele, HLA‐A*11:01:01:07, Identified by Third‐Generation Sequencing
Authors: Chen Yingjie , Wang Yuqi , Zhu Huachao , Ren Juan , Wang Xiaoning 
Published: November 2024

ABSTRACTHLA‐A*11:01:01:07 differs from HLA‐A*11:01:01:01 by a single nucleotide exchange in intron 1.
Identification of the Novel HLA‐DQA1*05:01:16 Allele by Next Generation Sequencing in a Chinese Individual
Authors: Liu Jie , Quan Zhan‐Rou , Yang Bing‐Na , Song Jia‐Min , Zou Hong‐Yan 
Published: November 2024

ABSTRACTHLA‐DQA1*05:01:16 differs from DQA1*05:01:01:01 by two nucleotide substitutions, one in exon 4 and one in intron 1.
The index of equidimensional flag manifolds
Authors: Basu Samik , Kundu Bikramjit 
Published: November 2024

AbstractIn this paper, we consider the flag manifold of orthogonal subspaces of equal dimension that carries an action of the cyclic group of order . We provide a complete calculation of the associated Fadell–Husseini index. This may be thought of as an odd primary version of the computations of Baralić, Blagojevic, Karasev, and Vucic, for the Grassmann manifold . These results have geometric consequences for ‐fold orthogonal shadows of a convex body.
Automated Grayscale Modulation to Enhance Digital Light Processing Fabrication Accuracy by Correcting Nonuniform Illumination
Authors: Subedi Saroj , Shovon S. M. Abu Naser , Ware Henry Oliver T. 
Published: November 2024

Abstract
In this study, we addressed the challenge of nonuniform illumination in custom digital light processing (DLP) systems, often caused by imperfections in the digital micromirror device (DMD) or misalignments in the optical assembly. These issues lead to dimensional inconsistencies across the fabrication area. To overcome this, we developed an automated system for generating a “grayscale” mask that compensates for nonuniform illumination. This system serves as a preprinting calibration procedure, enhancing the precision of three-dimensional (3D) printed features. Our approach involves dividing the fabrication area into a mesh grid where in situ light intensities are measured. The system then calculates and acquires grayscale values that correspond to the minimum light intensity, thereby creating a grayscale mask that levels light distribution across the printing area. Additionally, we outline a method to generate grayscale masks for various light-emitting diode (LED) excitation powers (LEPs) based on initial data from three predefined powers. We evaluated the effectiveness of this method by comparing features printed with standard “full white” images to those adjusted with our grayscale-modulated images. The results show significant enhancements in both uniformity and dimensional accuracy, confirming the efficacy of our approach. This study demonstrates the potential of grayscale modulation to resolve illumination issue in DLP manufacturing to ensure higher precision in printed features.
Genomic characterization of
Orthonairovirus haemorrhagiae
(Crimean-Congo hemorrhagic fever virus) outbreak in North Macedonia
Authors: Boshevska Golubinka , Emmerich Petra , von Possel Ronald , Jancheska Elizabeta , Buzharova Teodora , Kochinski Dragan , Tóth Gábor Endre , Cadar Dániel , Osmani Dugagjin 
Published: November 2024

ABSTRACT

Crimean-Congo hemorrhagic fever virus (CCHFV) is a significant tick-borne virus causing severe hemorrhagic disease with high fatality rate. This report presents the genomic characterization of CCHFV strain from North Macedonia’s first outbreak in over 50 years, emphasizing the importance of genomic surveillance in tracking virus evolution and spread patterns in this region.
A novel
Alteromonas
phage with tail fiber containing six potential iron-binding domains
Authors: Yu Chen , Yu Meishun , Ma Ruijie , Wei Shuzhen , Jin Min , Jiao Nianzhi , Zheng Qiang , Zhang Rui , Feng Xuejin 
Published: November 2024

ABSTRACT

Viruses play a vital role in regulating microbial communities, contributing to biogeochemical cycles of carbon, nitrogen, and essential metals.
Alteromona
s is widespread and plays an essential role in marine microbial ecology. However, there is limited knowledge about the interactions of
Alteromonas
and its viruses (alterophages). This study isolated a novel podovirus, vB_AmeP-R22Y (R22Y), which infects
Alteromonas
marina SW-47 (T). Phylogenetic analysis suggested that R22Y represented a novel viral genus within the
Schitoviridae
family. R22Y exhibited a broad host range and a relatively large burst size, exerting an important impact on the adaptability and dynamics of host populations. Two auxiliary metabolic genes, encoding Acyl carrier protein and AAA domain-containing protein, were predicted in R22Y, which may potentially assist in host fatty acid metabolism and VB12 biosynthesis, respectively. Remarkably, the prediction of the R22Y tail fiber structure revealed six conserved histidine residues (HxH motifs) that could potentially bind iron ions, suggesting that alterophages may function as organic iron-binding ligands in the marine environment. Our isolation and characterization of R22Y complements the Trojan Horse hypothesis, proposes the possible role of alterophages for marine iron biogeochemical cycling, and provides new insights into phage-host interactions in the iron-limited ocean.

IMPORTANCE

Iron (Fe), as an essential micronutrient, is often a limiting factor for microbial growth in marine ecosystems. The Trojan Horse hypothesis suggests that iron in the phage tail fibers is recognized by the host’s siderophore-bound iron receptor, enabling the phage to attach and initiate infection. The potential role of phages as iron-binding ligands has significant implications for oceanic trace metal biogeochemistry. In this study, we isolated a new phage R22Y with the potential to bind iron ions, using
Alteromonas
, a major siderophore producer, as the host. The tail fiber structure of R22Y exhibits six conserved HxH motifs, suggesting that each phage could potentially bind up to 36 iron ions. R22Y may contribute to colloidal organically complexed dissolved iron in the marine environment. This finding provides further insights into the Trojan Horse hypothesis, suggesting that alterophages may act as natural iron-binding ligands in the marine environment.
Detrital zircon provenance links between outcrop and subsurface, Rocas Verdes and Magallanes-Austral Basins, Patagonia
Authors: Almonte N. Gross , Malkowski M.A. , Dobbs S.C. , Graham S.A. 
Published: November 2024

Abstract
Analyzing how provenance signatures of tectonically complex ancient sedimentary basins vary between the outcrop and the subsurface provides a more complete sediment provenance history. The 500+-km-long outcrop belt of the Rocas Verdes and the Magallanes-Austral Basins in southern Patagonia and its subsurface to the east allow us to constrain relationships between longitudinal and transverse sediment sources feeding the basin. New detrital zircon U-Pb ages (n = 2558) from nine subsurface core samples from the Springhill, Piedra Clavada, and La Anita Formations along a 140 km E-W seismic reflection transect (50°S, 71.5°W–69.5°W) reveal the provenance of the basin's eastern subsurface extent and the influence that tectonic activity can have on sediment capture. Detrital zircon ages (n = 1068) were also collected from four outcrop Springhill Formation samples 140 km NW from the transect near Lago San Martín. Maximum depositional ages (MDAs) from the Springhill Formation cores range from 159 to 157 Ma, which are older than correlative outcrop ages of 151–148 Ma. MDAs from the Piedra Clavada and La Anita Formations range from 93.7 to 91.5 Ma and from 79.3 to 78.3 Ma, respectively, and overlap in age or are slightly younger than outcrop ages. The unimodal Late Jurassic age distribution from the Springhill Formation suggests that it almost exclusively was sourced by recycling of the underlying El Quemado Complex. Early–Middle Jurassic ages in the Early Cretaceous Piedra Clavada Formation samples suggest the basin was either sourcing from the North Patagonian Massif to the N-NE and from the Deseado Massif to the NE or recycling exhumed volcaniclastic sequences in the northern margin of the basin. By the Late Cretaceous, the basin fill was more locally sourced, as suggested by the muted abundance of Early–Middle Jurassic ages in La Anita Formation samples and a second mode of Late Jurassic–Early Cretaceous ages locally derived from recycling of the exhumed El Quemado Complex from the Patagonian fold-and-thrust belt. We suggest that the latitudinal and local transverse drainages that sourced the Magallanes-Austral Basin outcrop belt also fed the eastern, subsurface extent of the basin. Results of this work highlight the importance of using several types of provenance methods and a three-dimensional approach to study the erosional history of sedimentary basins.
Perception doesn't match reality: Unraveling gender disparities in Earth scientists' productivity during work-from-home initiatives
Authors: Hatherly Sarah , Spencer Christopher , Pedersen Alexandra 
Published: November 2024

Abstract
Work-from-home initiatives have led to a disproportionate impact among different genders. An individual's perception of their own productivity is significant in understanding how equity-deserving groups are affected by disruptions to normal routines. The term “equity-deserving groups” is common in Canadian academia and is used at Queen's University to convey that seeking equity should not be placed on the group, but rather on systemic, cultural, and societal change. Despite many faults, peer-reviewed publications are a key metric of academic productivity, as they are a vital component of career advancement. Using methods based on sex (female versus male) and gender (women versus men), this study investigates how both the perceived and measured productivity of Earth scientists was impacted by global COVID-19 work-from-home initiatives. Bibliometric and survey-based data are used to evaluate and compare the productivity of Earth scientists. Although there are inherent flaws in directly comparing sex and gender, the results of this study contribute to the understanding of how sex- and gender-minorities have been impacted by work-from-home initiatives. Our research shows that in a normal year, females publish proportionally to males, and that the proportion of female first authors increased between the 2019–2020 (“pre-pandemic”) and 2020–2021, 2021–2022, and 2022–2023 (“during pandemic”) years. This finding is contrary to the perceived productivity between women and men and indicates that our perceptions may not always match reality. Although women and men are publishing at nearly identical rates based on their proportions within our field, women perceive themselves as less productive, which creates a disconnect between perception and the data. We posit that the more negative perception of self-productivity among women and early-career researchers can lead to mental health issues and a lack of confidence. Support structures should therefore be focused on these groups to ensure more equitable outcomes.
Enablers and barriers to the implementation of breast self-examination (BSE) education programmes among adolescent girls in Sub-Saharan Africa (SSA): an integrative systematic review protocol
Authors: Hlormenu Benedictus Atsu , Osei Bonsu Emmanuel , Boadi Caleb , Dormechele William , Adams Mercy Oseiwah , Bossman Bright Boatey , Addo Stephen Kwakye , Addo Isaac Yeboah 
Published: November 2024

BackgroundBreast cancer is emerging as a leading cause of mortality among women and adolescent girls in Sub-Saharan Africa (SSA). However, there is a lack of clarity on the enablers and barriers associated with the implementation of preventive strategies, such as breast self-examination (BSE), particularly among adolescent girls.ObjectiveThis paper presents a protocol for conducting a systematic review aiming to synthesise studies on the enablers and barriers to implementing BSE education programmes among adolescent girls in SSA.Methods and analysisThe systematic review will be conducted from December 2024 to August 2025, following the predefined methodological framework outlined in the PRISMA guidelines. To gather relevant studies, a comprehensive search will be conducted across four main online databases, namely PubMed, Scopus, Cochrane Library and EMBASE, along with other relevant grey literature sources, such as Google Scholar, to identify pertinent literature on this topic. The screening process will involve an initial review of titles and abstracts to quickly identify relevant studies, followed by a thorough assessment of the full-text versions of selected studies. Two reviewers, working independently, will extract data and evaluate the risk of bias in the included studies using either the Joana Briggs Institute’s Critical Appraisal tool or Cochrane’s Risk of Bias tool V.2 (RoB 2). The focus of the included studies will be on BSE among adolescents aged 10 to 19 years of age. Depending on the results of the literature search and the characteristics of the findings in the selected studies, we will conduct a meta-analysis if possible. Alternatively, a narrative synthesis will be conducted. The review will provide empirical evidence to inform health promoters and policymakers in advocating for BSE, particularly, among adolescent girls in SSA, with the ultimate goal of mitigating the risk of breast cancer.Ethics and disseminationSince this study is based on the analysis of already published research articles, ethical approval is not required. The results will be disseminated through peer-reviewed academic publications and presentations, informing further research and practice regarding BSE education programmes.
Can resistance exercise prevent breast cancer–related lymphoedema? A systematic review and metanalysis protocol
Authors: Aguilera-Eguía Raúl Alberto , Seron Pamela , Gutiérrez-Arias Ruvistay , Zaror Carlos 
Published: November 2024

Introduction
Evidence shows that resistance training (RT) reduces lymphoedema in patients with breast cancer–related lymphoedema (BRCL), making it a safe and efficient intervention. However, it is uncertain if RT is safe and effective in patients at risk of developing BRCL. This systematic review (SR) protocol aims to describe all methodological aspects in order to evaluate the short-, medium- and long-term effects of RT on the prevention of BCRL.

Materials and methods
Throughout 2024, randomised clinical trials (RCTs) will be identified in electronic databases MEDLINE/PubMed, Embase, Cochrane Central Register of Controlled Trials, PEDro and LILACS. Only studies in English, Spanish and Portuguese will be included. Grey literature and clinical trial registration will also be reviewed. The primary outcome will be the occurrence of lymphoedema and quality of life. Second, pain intensity, upper limb function, range of movement, grip strength and adverse events will be considered. The individual studies’ risk of bias will be evaluated using the Cochrane Risk of Bias 2.0 tool. Pairwise meta-analyses using a frequentist approach and random effects model will be conducted. The Grading of Recommendations Assessment, Development and Evaluation system will be used to evaluate the certainty of the evidence.

Ethics and dissemination
This protocol does not require the approval of an ethics committee, as it is a secondary study. The results will be disseminated through peer-reviewed publications.

PROSPERO registration number
CRD42023455720.
Features of causes of indirect certified disaster-related death in areas affected by the Fukushima Daiichi nuclear power plant accident: an observational study
Authors: Uchi Yuna , Sawano Toyoaki , Kawashima Moe , Nonaka Saori , Yoshimura Hiroki , Kitazawa Kemmei , Sakakibara Mamoru , Sudo Makiko , Yagiuchi Kazuko , Otsuki Mako , Hori Arinobu , Ozaki Akihiko , Yamamoto Chika , Zhao Tianchen , Oikawa Tomoyoshi , Niwa Shinichi , Tsubokura Masaharu 
Published: November 2024

ObjectivesTo investigate the details of disaster-related deaths due to the indirect health effects of the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident following the Great East-Japan Earthquake in 2011 and serve as a source of reference in the event of similar circumstances in the future.DesignA retrospective observational study.SettingMinamisoma City, Fukushima Prefecture, Japan, which is located 13–38 km north of the FDNPP.Participants520 residents of Minamisoma City, Fukushima Prefecture, who were certified as having died from disaster-related causes between September 2011 and February 2021.ResultsThe most common cause of death was circulatory system diseases (27.7%), followed by respiratory system diseases (25.0%) and neoplasms (15.4%). The prevalence of circulatory and respiratory diseases is higher in older people, suggesting that they are more susceptible to indirect health effects due to the environmental changes related to evacuation. Malignant neoplasms accounted for the third and leading cause of death overall and for people in their 50s, respectively, implying the potential impact of evacuation on cancer diagnosis and treatment. Suicide is the leading cause of death among younger people and can occur even long after a disaster, which shows the psychological impact of environmental changes.ConclusionTo prevent indirect disaster-related deaths in the future, it is important to consider appropriate intervention methods by age group and period since disaster occurrence. It is especially important to improve the environment of evacuation shelters and establish a healthcare system for evacuees, create a system for cancer screening and treatment during evacuation and expand long-term suicide prevention measures.