bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENINGKATAN KUALITAS SUMBER DAYA MANUSIA PEMUDA PESISIR MELALUI PELATIHAN MANAJEMEN KEPEMIMPINAN DI KECAMATAN POTO TANO KABUPATEN SUMBAWA BARAT
Authors: Ibrahim Ibrahim , Kamaluddin Kamaluddin , Mas'ad Mas'ad , AM Junadi 
Published: April 2019

Penelitian ini bertujuan untuk mengetahui dampak program pelatihan manajemen Kepemimpinan dalam meningkatkan Sumberdaya Manusia (SDM) kepemudaan daerah pesisir di Kecamatan Poto Tano Kabupaten Sumbawa Barat. Metode Penelitian menggunakan pendekatan deskriptif kualitatif. Pengumpulan data menggunakan wawancara mendalam dengan pihak pemuda. Analisis data dalam penelitian ini menggunakan model analisis interaktif yaitu analisis dengan menggunakan reduksi data, display data, dan verifikasi dan kesimpulan. Hasil Penelitian menunjukan bahwa pelatihan manajemen kepemimpinan kepemudaan pada daerah pesisir berdampak positif karena tercipta perubahan yang diinginkan meskipun belum nampak secara menyeluruh dari peserta yang mengikuti pelatihan. Secara keseluruhan hasil program ini diharapkan pemuda daerah pesisir di Kecamatan Poto Tano dapat memiliki beberapa keahlian yang dapat dijadikan sebagai modal dalam mengembangkan diri. Para pemuda dapat menumbuhkembangkan ketrampilan sebagai modal utama terutama pada sektor UMKM yang dipandang sangat menjanjikan keuntungan. Potensi pemudadapat dikembangkan dengan membentuk kelompok usaha bersama, sehingga dapat kesejahteraan keluarga dan masa depan yang lebih berkemajuan.
EFEKTIVITAS SHOKIVI DESINFECTION TERHADAP PENURUNAN ANGKA KUMAN UDARA PADA RUANG KELAS GEDUNG R2 LANTAI 2 KAMPUS 7 POLTEKKES KEMENKES SEMARANG TAHUN 2018
Authors: Prajawanti Nur Latifah , Cahyono Tri , Gunawan Asep Tata 
Published: April 2019

Ruang kelas mempunyai risiko terjadinya pencemaran udara khususnya mikrobiologi. Angka kuman udara dapat disebabkan oleh aktivitas penghuni, sehingga dapat menimbulkan gangguan kesehatan. Tujuan penelitian ini mengetahui efektivitas Shokivi Desinfection terhadap penurunan angka kuman udara pada ruang kelas gedung R2 lantai 2 jurusan Kesehatan Lingkungan Purwokerto Kampus 7 Poltekkes Kemenkes Semarang tahun 2018. Jenis penelitian ini adalah Quasi eksperiment dengan rancangan penelitian time series pre test – post test design. Hasil pemeriksaan angka kuman udara pada ruang perlakuan diperoleh hasil rata-rata angka kuman udara sebesar 150,25 koloni/jam/feet2. Hasil penghitungan efektivias shokivi desinfeksi dalam penurunan angka kuman diperoleh hasil 30,57 %. Simpulan dari hasil penelitian bahwa ada perbedaan yang tidak signifikan efektivitas Shokivi Desinfection terhadap penurunan angka kuman udara pada ruang kelas gedung R2 lantai 2 Kampus 7 Poltekkes Kemenkes Semarang tahun 2018.Disarankan sebaiknya penggunaan shokivi desinfection diseuaikan dengan volume ruangan.
An open label trial of a standardized extract of cultured Lentinula edodes mycelia (ECLM) in children with refractory epilepsy
Authors: Mikhailichenko Natalia V. , Kulagin Viacheslav , Shio Takuma , Takanari Jun , Cheng-Chung Wei James 
Published: April 2019

Objectives: This open-label trial was performed to assess the immune markers in a cohort of children with refractory epilepsy in order to identify diagnostic and therapeutic markers and to also investigate the effect of an immunologically active supplement derived from mushroom, a standardized extract of cultured Lentinula edodes mycelia (ECLM), on the clinical status and on the immunological markers in the subjects.Methods: Eighteen pediatric patients diagnosed with refractory epilepsy in which antiepileptic therapy was not effective were enrolled. All subjects were also treated with anticonvulsant medications for their seizures. Patients were administered 0.6 g/day (< 3 years old) or 1.2 g/day (> 3 years old) of ECLM (fine-granule equivalent) orally for one month. Immunological markers were assessed at baseline and after one month. Video electroencephalogram (EEG) was taken twice, once before the trials and once at the end of ECLM treatment. Seizure frequency and behavioral symptoms were measured by a questionnaire survey of the parents. A two-month follow-up was also performed for surveillance of secondary infections.Results: The subjects treated with ECLM showed significant elevation of several immune parameters including immunoglobulin G (IgG), CD3, CD4, and CD20 lymphocytes, and phagocytic index. Six of the 18 children on stable anticonvulsant drugs had fewer seizures reported during the ECLM treatment. The ECLM-treated patients also had less sharp and spike activity in the EEG measurement. At the two-month follow-up, the ECLM-treated subjects had developed fewer infections and viral syndromes compared to their condition before the trial. The children’s family reported other subjective behavioral improvements, leading to improved quality of life (QOL). Conclusion: ECLM administration to the pediatric patients with refractory epilepsy contributed to improvement of epileptic manifestation and decrease of epileptic seizure, possibly by suppressing the reactivation of herpes virus, as well as improvement of QOL. In addition, it was demonstrated that ECLM is a safe supplement for infants and children. Keywords: ECLM, epilepsy, children, pediatric, mushroom
Continuous intravenous vitamin C in the cancer treatment: re-evaluation of a Phase I clinical study
Authors: Mikirova Nina , Casciari Joseph , Hunninghake Ronald 
Published: April 2019

Background: Intravenous high-dose vitamin C (IVC) therapy is widely used in naturopathic and integrative oncology. A number of Phase I and Phase II clinical trials were launched to prove the benefits of the IVC therapy. Many case studies demonstrated the effectiveness of IVC, with various degrees of success. Clinical trials using IVC to treat cancer have, to date, demonstrated its safety without conclusively proven its efficacy. One difficulty in administering IVC is determining the optimal treatment schedule. To this end, data from a previous Phase 1 clinical trial conducted in 1998 using continuous vitamin C infusions was analyzed to examine the effects of this regimen on key prognostic parameters. Method: Twenty-four subjects were given continuous IVC at doses between 150 and 710 mg/kg/day. Most of the patients had colon cancer with liver and lung metastasis and three patients had pancreatic or liver cancer. All patients had several chemotherapy/radiation treatments before entering the study. Patients were treated by pharmaceutical grade sodium ascorbate diluted in Lactated Ringers solution with the rate of infusion of 20 ml/hr or 10 ml/hr for lower doses. This diluted solution was administered by continuous infusion.Results: Prior to treatment, serum lymphocyte counts and ascorbate concentrations tended to be low while serum levels of lactate dehydrogenase (LDH), neutrophils, and glucose tended to be high. Improvements were seen during IVC therapy. In patients with initially elevated neutrophil levels, numbers tended to decrease. In contrast, increased absolute neutrophil and lymphocyte numbers were seen in patients with initially low counts. Neutrophil to lymphocyte ratios (NLR) proved to be a good indicator of cancer patients’ survival times (high NLR, low survival). This was also true of LDH, creatinine, and glucose concentrations. In patients with the highest pre-treatment NLR, rate of growth of this ratio decreased significantly during therapy. IVC treatments were also associated with decreases in glucose concentrations, restoration of vitamin C levels, and, in about 40% of cases, reductions in LDH levels. Conclusions: As the result of the study we found that continuous IVC infusions improved several parameters associated with poor cancer prognosis. The data suggests a strategic benefit to using lower IVC doses in continuous infusions: raising the dose above 300 mg/kg/day (20 grams in 70 kg human) increased the frequency of side effects without noticeably increasing plasma ascorbate levels. Moreover, improvements in lymphocyte counts at low IVC doses tended to decrease at the higher doses. In conclusion, continuous infusions had benefits to cancer patients and further research in this area is warranted.Keywords: ascorbic acid; continuous infusion; cancer patients; clinical trial; lymphopenia; neutrophil to lymphocyte ratio; hyperglycemia; safety.
The Correlation between Calcium Serum and Calcium Urine Level with the Blood Pressure in Preeclampsia
Authors: Suryono Deni W. 
Published: April 2019

Objective: To analyze the differences of calcium serum and calcium urine level in preeclampsia and normal pregnancy, and to analyze the correlation between calcium serum and calcium urine level with blood pressure.

Method: This study is a cross sectional study with 44 women with preeclampsia and 45 women with normal pregnancies, that meet our inclusion criteria. The samples were obtained from Dr. Hasan Sadikin Hospital and six satellite hospitals from June to September 2011. The comparison of mean calcium serum and calcium urine
level of the preeclampsia group was calculated using Mann-Whitney test, and the correlation between calcium serum and calcium urine level and preeclampsia were calculated using Rank Spearman correlation test.

Result: The result of the characteristic test in two groups of study shows that both groups are homogenic and comparable. The mean of calcium serum level in women with preeclampsia (7.97 mg/dl) is lower than in normal pregnancy (8.82 mg/dl) with p
High Level of Tumor Necrosis Factor (TNF)-α is a Risk Factor for Preeclampsia
Authors: Anom I.G.N. 
Published: April 2019

Objective: To define that elevated TNF-α serum level was the risk factor of preeclampsia in pregnancy.

Method: This research is a case-control study. From 56 pregnant women, there are 28 women with preeclampsia and the other 28 women with normal pregnancy. Then the serum level of TNF-α was obtained at Prodia’s clinical Laboratory Denpasar. Data’s normality test was done with Kolmogorov-Smirnov, then an analysis of data was done with Independent Sample Test, predictive value a = 0.05.
To define the role of TNF-α level in preeclampsia, Chi-Square test was chosen.

Result: From this research we found the average level of TNF-α in preeclampsia (6.64 ± 7.64 pg/ml) was higher than in normal pregnancy (2.42 ± 1.77 pg/ml). Analysis with t-independent test shows that the t-value was 2.85 and p-value was 0.006, which means that the average level of TNF-α between the two group was significantly
different (with predictive value, p
The Serum Level of Vascular Endothelial Growth Factor (VEGF) is Declined after Paclitaxel-Carboplatin Combined Chemotherapy Treatment on Epithelial Ovarian Cancer
Authors: Abdullah Amelia 
Published: April 2019

Objective: To assess the effect of Paclitaxel-Carboplatin combination on epithelial ovarian cancer by studying the changes in VEGF serum levels after receiving 3 series of chemotherapy.

Methods: This was a cohort study conducted at several teaching hospitals in Obstetrics and Gynecology Department of the Faculty of Medicine, Hasanuddin University from April 2011 to March 2012. The subjects were patients with ovarian cancer who met the inclusion criteria and had undergone surgery. The clinical staging was determined with 2009 FIGO criteria. They went through histopathology examination to determine the histological type and cell differentiation of the lesion. They also went through combined chemotherapy of Paclitaxel and Carboplatin. The data were analyzed with paired t-test.

Results: The study reveals that out of 30 cases of ovarian cancer who received a combination chemotherapy, most were < 45 years of age (53.33%), nulliparous (46.7%), serosum type (53.3%), with moderate differentiation (36.7%), and in advanced stage (73.3%). The VEGF serum level after 3 series of chemotherapy was lower than before (the average value: 294.67 vs 572.77 ng/ml). There was a significant change in VEGF serum level after receiving chemotherapy (p=0.000). The VEGF serum level of advanced-stage and early stage epithelial ovarian cancer after chemotherapy decreases significantly
(p=0.000 and p=0.011). The advanced-stage cases showed more responses to chemotherapy than the early-stage did. There was a tendency that adenocarcinoma serosum type was more responsive
to the therapy than mucinosum type (p=0.000 vs 0.003).
Conclusion: There is no difference in VEGF serum level based on cell differentiation but there is a tendency that well and moderate differentiated cells have a greater change than the poor differentiated cells (p=0.003, p=0.003 vs p=0.019).
[Indones J Obstet Gynecol 2012; 36-3: 135-9]

Keywords: carboplatin, epithelial ovarian cancer, paclitaxel, VEGF
Severe Complication of Uterine Perforation and Ileum Prolapse after Having Unsafe Abortion
Authors: Pradana Aryando 
Published: April 2019

Objective: Discuss complication after unsafe abortion and management of uterine perforation after curettage.

Methods: Case report.

Conclusion: Uterine perforation and ileum prolapse in this patient was a complication from unsafe abortion from unregistered health practicioner, fortunately the outcome is good, although actually it could be prevent.
[Indones J Obstet Gynecol 2012; 36-3:150-3]

Keywords: hysteroraphy, ileum anastomose, ileum laceration, ileum prolapse, ileum resection, incomplete abortion, uterine perforation
A Comparison between the Level of Interleukin 10 (IL-10) in Aterm and Preterm Labor
Authors: Lisangan Yusri 
Published: April 2019

Objective: To compare the level of interleukin 10 in aterm and preterm labor.

Method: The research was conducted from November 1st 2011 until January 31st 2012. The subjects were pregnant women underwent labor during the period who had agreed to participate in this study. The study was conducted in the Obstetrics and Gynecology departments of several teaching hospitals of Hasanuddin University in Makassar. The study design was cross sectional with 48 samples. The data were analysed by using the Mann Whithney test.

Results: The result revealed that there was an increase of interleukin 10 level in mothers with preterm labor, in comparison with the control group (p < 0.05).

Conclusion: The level of interleukin 10 in mothers with preterm labor are higher than aterm labors less than espective.
[Indones J Obstet Gynecol 2012; 36-4: 163-6]

Keywords: interleukin 10, preterm labor
Expression of Fas Ligand is Higher in Early Stage Cervical Cancer with Lymph Nodes Metastasis
Authors: Irwanto Yahya 
Published: April 2019

Objective: To know whether the expression of Fas Ligand has correlation with incidene of metastasis of pelvic lymph node and lymph-vascular stromal invasion (LVSI).

Methods: All patients diagnosed of cervical cancer stage IB or IIA who underwent radical hysterectomy in Dr. Cipto Mangunkusumo Central General Hospital from January 2008 until December 2009 were included in analytic cross sectional study. We tested expression of Fas Ligand in cervical cancer specimen by immunohystochemistry with monoclonal antibody. The expression of Fas Ligand was compared between the group of patients with a positive and negative pelvic lymph node and between LVSI positive and negative. The difference of expression in both group were statistically analized with Chi-square test and the correlation Spearman test.

Result: Ninety one patients underwent radical hysterectomy for two years and 43 patients were included in these study. The expression of Fas Ligand in 7 patients (16.3%) were negative and the others were positive, with weak, moderate and strong expression were 4 (9.3%), 27 (62.8%), and 5 (11.6%) respectively. The expression of
Fas Ligand was significantly higher in the group of patients with positive pelvic lymph node compared to the group of the patients with negative pelvic lymph node (p=0.007) but there was no significant difference between group of the patients with LVSI positive and negative. With Spearman test, we found that the expression of Fas
Ligand had a strong correlation with pelvic lymph nodes metastasis (coeff. correlation=0.519 and p=0.00) and have no correlation with LVSI (coef. corellation=0.112 and p=0.474).

Conclusion: These finding suggested that expression of Fas Ligand in cervical cancer patients has a strong correlation with the incidence of pelvic lymph node metastasis and none with LVSI.
[Indones J Obstet Gynecol 2012; 36-4: 194-9]

Keywords: cervical cancer, fas ligand, immunohystochemistry, LVSI, pelvic lymph node metastasis
Outcome of Clubfoot Correction at ‘Walk for Life’ Clinic of Mymensingh Medical College Hospital: A Four Year Review
Authors: Rahman F , Chowdhury MH , Kabir H , Alam J , Uddin J , Evans AM 
Published: April 2019

Background: Every year in Bangladesh an estimated 3500 - 4000 children are born with a clubfoot deformity, which is approximately one of every 1000 children born in Bangladesh. Left untreated, the condition leads to lifelong deformity causing individual disability and potential unproductivity. Affected children grow up as burden to the family and ultimately leads to significant poverty.
Methods: This study was conducted at the ‘Walk for Life’ (WFL) clinic Mymensingh Medical College Hospital (MMCH) during February 2011 to December 2014.The non-surgical Ponseti method was applied by the orthopaedic surgeon and physiotherapist. Follow-up for relapsed deformity in children who were treated in 2011 occurred in 2015.
Results: A total of 577 children comprised of 175 (30.32%) female and 402 (69.7%) male, a gender rati o F: 2.29 M. Completions of treatment data were available for 471 children, as 106 had dropped out at different stages of the treatment cycle. Sadly, 12 children had died. In 440 (76.4%) children, the parents’ monthly income approximated Tk. 5000, and 364 (82.8%) lived in tin shed houses. The parents with lowest incomes predominated for children with clubfoot. Most parents 383(66.4%) were labourers, small business and service workerswith the lowest income. A family history of clubfoot deformity was found in 8.3%, of which 2.8% were cousins, 1.7% were an uncle.The average number of corrective plaster casts applied before the tenotomy was 3.32% in 477 children. In 73.0% of childrenthree to six casts were used for initial correction. An Achilles tenotomy was performed in 81.0% children, 18% did undergo a tenotomy and one child had multiple tenotomies.Four years following of initial treatment, 99 children were reviewed, and 98 were walking and running. Parents’ satisfaction was 96.0%. Thirteen percent children showed relapse signs. Most of the children treated at the WFL clubfoot clinic were walking normally four years after initial treatment.
Conclusion: The Ponseti method is found to be very effective and especially for a developing country like Bangladesh. Poverty and housing condition may play a role in clubfoot disease. The dropout rate across the treatment cycle was 18.4%, warranting closer evaluation. The patronage of the Glencoe Foundation WFL clinics since 2009, played an important role in relieving thousands of Bangladeshi children from disability.
Bangladesh Med Res Counc Bull 2018; 44: 132-137
Comparison of Anti-Inflammatory Effect of Ethanolic Extract of Carica Papaya Leaves and Indomethacin in Carrageenan Induced Rat Paw Edema Animal Model
Authors: Sultana Afroza , Khan Asma , Afroz Rumana , Yasmeen Onayza , Aktar Muqbula Tasrin , Yusuf Md Abdullah 
Published: April 2019

Background: Carica papaya is very useful vegetables for daily living.
Objective: The purpose of the present study was to compare the anti-inflammatory effect of ethanolic extract of Carica papaya leaves and indomethacin in carrageenan induced rat paw edema animal model.
Methodology: This was an animal study carried out in the Department of Pharmacology at Dhaka Medical College, Dhaka, Bangladesh during the period from July 2014 to June 2015 for a period of one (01) year. The leaves of Carica Papaya collected from Botanical garden, Mirpur, Dhaka, Bangladesh. The animals were divided into four groups. Inflammation was produced by injecting 0.1 ml of 1% carrageenan solution in normal saline in all experimental animals. Group I were served as control that received normal saline. Group II were received ethanolic extract of Carica Papaya. Group III were received ethanolic extract of Carica Papaya leaves. Group IV were received indomethacin.
Result: The experiment was carried out on 48 Long Evan Norwegian rats. Rats were divided in 4 groups of six animals each. The mean initial antero-posterior diameter of rat’s paw of group I, II, III and IV were 3.83±0.04, 2.12±0.02, 1.74±0.01 and 1.60±0.03 respectively. The inhibition of edema formation were 44.64%, 54.57% and 58.22% in group II, III and IV respectively.
Conclusion: In conclusion the Carica papaya leaves has anti-inflammatory effect
Journal of Science Foundation 2018;16(2):49-53
Clinico-Demographic Profiles and Urinary Albumin in Prediction of Preeclampsia among Pregnant Women at a Tertiary Care Hospital
Authors: Begum Taslima , Ali Khr Md Shahjahan , Khanam Shafeya , Habib Md Anwar , Chaudhury Shipra , Jesmin Shahela , Akter Shimul 
Published: April 2019

Background: The clinical profiles and urinary albumin are very important for the prediction of preeclampsia among the pregnant women.
Objective: The purpose of the present study was to assess the clinical and demographic profiles as well as the urinary albumin for the prediction of preeclampsia among the pregnant women.
Methodology: This cohort study was conducted in the OPD of the Department of Obstetrics and Gynaecology at Rajshahi Medical College Hospital, Rajshahi, Bangladesh from January 2013 to December 2014 for a period of two (2) years. This study was carried on pregnant woman attending in outdoor department of Gynaecology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh before 20th weeks of pregnancy who were healthy normotensive primigravidae with singleton pregnancy. The details demographic profiles, edema were collected from the study population. Urinary albumin was estimated before 20th weeks and after 28th weeks of pregnancy.
Result: In the present study, 75 women were included; all were before 20th weeks of pregnancy without any complication or any risk factor for developing PE. Among the study group incidence of PE was 16%. The population are 24(32.0%) low, 31(41.3%) middle and 20(26.7%) high in socio economic conditions. Education level of study population was 45% completed primary education level, illiterate (27%) and secondary education (28%). Edema was absent in 1st visit, in 2nd visit 6(+), 6(++) present who developed PE, 18(+) present who did not develop PE. Edema was absent in 1st visit and (+) 6(50.0%) and (++) in 6(50.0%) present who developed PE in 2nd visit. Urine albumin in 1st visit nil in 6(50.0%), trace in 3(25.0%) and (+) in 3(25.0%) who developed PE.
Conclusion: In conclusion housewife living in urban area in middle income socioeconomic condition are the most commonly presented with preeclampsia and urinary albumin is the most commonly detected in the pregnant women presented with preeclampsia
Journal of Science Foundation 2018;16(2):54-59
PENGARUH INOVASI PRODUK TERHADAP KINERJA PEMASARAN INDUSTRI MEBEL DI KABUPATEN PASURUAN
Authors: Nasir Akhmad 
Published: April 2019

Strategi pemasaran yang diharapkan perusahaan adalah bagaimana untuk
meningkatkan jumlah penjualan produk sesuai target. Strategi yang dibuat oleh
perusahaan diarahkan untuk menghasilkan kinerja, terutama kinerja pemasaran. Pada
perusahaan besar inovasi produk sudah menjadi strategi pasar yang berkelanjutan sesuai
kebutuhan guna mempertahankan kinerja pemasaran, namun bagaimana bagi
perusahaan kecil dan menengah seperti industri mebel yang masih memiliki
keterbatasan pemahaman terhadap strategi pemasaran. Bagi perusahaan kecil dan
menengah apakah inovasi produk merupakan hal yang penting bagi kelangsungan bisnis
secara berkelanjutan. Sampel penelitian ini pada perusahaan mebel di Kabupaten
Pasuruan yang berjumlah 38 responden. Teknik analisis data yang digunakan peneliti
adalah analisis regresi sederhana. Inovasi pada produk berpengaruh terhadap kinerja
pemasaran, untuk itu perusahaan ditekankan untuk menjaga kualitas produk yang sudah
dipercaya konsumen.