bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treating EGFR-Mutated Oncogene-Addicted Advanced Non–Small-Cell Lung Cancer in the Era of Economic Crisis in Greece: Challenges and Opportunities
Authors: Fountzilas Elena , Levva Sofia , Mountzios Giannis , Polychronidou Genovefa , Maniadakis Nikos , Kotoula Vassiliki , Fountzilas George 
Published: September 2018

Purpose Because of the profound financial crisis that commenced in Greece in 2010, severe cuts in health care spending and other restriction measures led to significant delays in the reimbursement of novel antineoplastic agents. In 2011, the Hellenic Society of Medical Oncology initiated a program of early access to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors for the treatment of patients with advanced, EGFR-mutant non–small-cell lung cancer (NSCLC). We evaluated treatment patterns and clinical outcomes in patients with EGFR-mutant or wild-type disease treated at a large center in Greece throughout the period of financial crisis. Patients and Methods From 2011 through 2015, 252 patients with newly diagnosed advanced NSCLC were treated at the Department of Medical Oncology of the Papageorgiou Hospital, a tertiary cancer center in northern Greece. We retrospectively reviewed patient medical records to obtain clinicopathologic characteristics, EGFR mutation status, and follow-up data. The primary end point was time to treatment failure. Results Of the 198 evaluable patients, 25 (12%) had EGFR mutations. All patients with EGFR mutations except one received treatment with an EGFR tyrosine kinase inhibitor. Median times to treatment failure for patients with EGFR-mutant and wild-type disease were 15.8 and 7.1 months, respectively (hazard ratio, 0.58; 95% CI, 0.35 to 0.95; P = .031). There was no difference in overall survival between the two groups ( P = .293). No deviation from treatment guidelines or discontinuation of treatment regimens occurred because of logistic reasons or drug shortages. Conclusion Despite restrictions in the reimbursement policy and accompanying controls in the use of high-cost medicines, the national program enabled treatment of patients with EGFR-mutant NSCLC according to established guidelines. Therefore, the clinical outcomes of such patients treated in Greece during the economic crisis were in accordance with international standards.
Modelling brain dopamine-serotonin vesicular transport disease in Caenorhabditis elegans
Authors: Young Alexander T. , Ly Kien N. , Wilson Callum , Lehnert Klaus , Snell Russell G. , Reid Suzanne J. , Jacobsen Jessie C. 
Published: September 2018

ABSTRACT
Brain dopamine-serotonin vesicular transport disease is a rare disease caused by autosomal recessive mutations in the SLC18A2 gene, which encodes the VMAT2 protein. VMAT2 is a membrane protein responsible for vesicular transport of monoamines, and its disruption negatively affects neurotransmission. This results in a severe neurodevelopmental disorder affecting motor skills and development, and causes muscular hypotonia. The condition was initially described in a consanguineous Saudi Arabian family with affected siblings homozygous for a P387L mutation. We subsequently found a second mutation in a New Zealand family (homozygous P237H), which was later also identified in an Iraqi family. Pramipexole has been shown to have some therapeutic benefit. Transgenic Caenorhabditis elegans were developed to model the P237H and P387L mutations. Investigations into dopamine- and serotonin-related C. elegans phenotypes, including pharyngeal pumping and grazing, showed that both mutations cause significant impairment of these processes when compared with a non-transgenic N2 strain and a transgenic containing the wild-type human SLC18A2 gene. Preliminary experiments investigating the therapeutic effects of serotonin and pramipexole demonstrated that serotonin could successfully restore the pharyngeal pumping phenotype. These analyses provide further support for the role of these mutations in this disease.
Healing capacity of bone marrow mesenchymal stem cells versus platelet-rich fibrin in tibial bone defects of albino rats: an in vivo study
Authors: Rady Dina , Mubarak Rabab , Abdel Moneim Rehab A. 
Published: September 2018

Background: Various techniques for tissue engineering have been introduced to aid the regeneration of defective or lost bone tissue. The aim of this study was to compare the in vivo bone-forming potential of bone marrow mesenchymal stem cells (BM-MSCs) and platelet-rich fibrin (PRF) on induced bone defects in rats’ tibiae. Methods: In total, one defect of 3-mm diameter was created in each tibia of 36 Wistar male rats. There were two groups: group A, left tibia bone defects that received PRF; and group B, right tibia bone defects of the same animal that received BM-MSCs loaded on a chitosan scaffold. Subsequently, Scanning electron microscope/energy-dispersive X-ray (SEM/EDX) analyses was performed at 3 and 10 days, and 3 weeks post‑implantation and following euthanasia; (n=12). Results: The EDX analysis performed for each group and time point revealed a significant increase in the mean calcium and phosphorous weight percentage in the BM-MSC-treated group relative to the PRF-treated group at all-time intervals (P < 0.05). Moreover, the mean calcium and phosphorus weight percentage increased as time progressed since the surgical intervention in the PRF-treated and BM-MSCs groups (P < 0.05). Conclusions: In the present study, both BM-MSCs and PRF were capable of healing osseous defects induced in a rat tibial model. Yet, BM-MSCs promoted more adequate healing, with higher mean calcium and phosphorous weight percentages than PRF at all-time points, and showed greater integration into the surrounding tissues than PRF.
Case Report: Sporadic Burkitt lymphoma misdiagnosed as dental abscess in a 15-year-old girl
Authors: Cabras Marco , Arduino Paolo G. , Chiusa Luigi , Broccoletti Roberto , Carbone Mario 
Published: September 2018

Background: Burkitt lymphoma (BL) is a non-Hodgkin’s B-cell tumor that can be classified into three variants, based on clinical characteristics and epidemiology: endemic, human immunodeficiency-related and sporadic. Oral sporadic BL is quite an unusual entity, with the gastrointestinal trait being often the first site of appearance. Clinical finding: A 15-year-old patient that presented a symptomatic swelling of the right maxilla, unsuccessfully treated as a primary endodontic disease, displaying solid tissue on CT scan, “starry sky” pattern on oral biopsy, multifocal bone and lymph node uptake on PET. Diagnoses, interventions, and outcomes: A diagnosis of stage IV BL was formulated; Rituximab was then administered for three months according to Inter-B-NHL ritux 2010 protocol and CYM (cytarabine and methotrexate) chemotherapy. The patient was followed-up for three years, with no recurrence. Conclusion: It is important for general dental practitioners to suspect a malignancy in the differential diagnosis of unresponsive odontogenic infections in young healthy patients.
Estudo da Relação da Rede Globo e Youtube na Série Malhação
Authors: Coreixas Bárbara Mathias , Cruz Eduardo Picanço 
Published: September 2018

Este trabalho busca demonstrar a importância do marketing na internet e do surgimento do site devídeos YouTube, que vem sendo cada vez mais utilizado como mídia de promoção. Até mesmo grandesempresas de mídia estão se aliando ao site para distribuir conteúdo devido à evolução do mundodigital e ao novo cenário de convergência tecnológica. Primeiramente faremos uma introdução teóricapassando pela história do marketing, sua definição e principais conceitos. Falaremos também sobrecomposto de marketing, aprofundando principalmente a promoção, um dos quatro P’s do composto eelemento de suma importância para o presente trabalho. Por fim, falaremos sobre o sistema de parcerias do YouTube, dando como exemplo a parceirafirmada entre o site e a Rede Globo de Televisão, que possui um canal da telenovela “Malhação” no site.Concluindo, analisaremos a parceira identificando os benefícios que as empresas obtêm ao tornaremseparceiras.
The right politics: Conservative craft in a reactionary milieu
Authors: Kowolik Leopold 
Published: September 2018

Abstract
Current events have shown that conservative politics are not the same as reactionary politics although they often share political parties. When we realize that craft is inherently conservative, we can also reveal where craft risks being reactionary in its nostalgia. Subsequently we can illustrate craft’s inner logic, and in so doing rid craft’s identity of elements that serve either as nostalgic bid for pre-industrial simplicity or as a tool to be appropriated by consumerist branding falsely appealing to fictive notions of personal authenticity.
Hybrid design: Combining craft and digital practice
Authors: Bernabei Rina , Power Jacqueline 
Published: September 2018

Abstract
Digital fabrication technologies are transforming disciplines and their practices. It is now the norm for a product designer to undertake almost the entire design process, from creation to fabrication, using digital means. Yet, at the same time, traditional crafts are experiencing a resurgence, and craft outputs are valued in a world filled with cheap mass-produced artefacts. There are now an increasing number of design practitioners and researchers investigating how to merge traditional craft practices, forms and qualities with those of digital fabrication. This shift is leading to a new paradigm of digital craft that is influencing design narratives and practices. This collaborative, cross-disciplinary article, written from within the disciplines of interior design and product design, will provide a case study of one of the author’s product design practice outputs that reflects on the process of designing for both craft and digital fabrication. The resulting designs constitute a new form of hybrid materiality that applies a design model developed by the authors. This design model is called ‘user-completion’ and is situated at the intersection between craft, mass-customization, and mass-manufacture. The user-completion model provides a framework for designers to engage users in the making process by personalizing and completing their products. The case study explores how the user-completion model is contributing to the redefining of craft through the use of digital manufacturing technologies within design disciplines.
‘I like knowing when the zombies arrive, I won’t be naked’: Young women and leisure handcrafting in the United States
Authors: Stalp Marybeth C. , Gardner Emily A. , Beaird Ashley 
Published: September 2018

Abstract
In a modern world where technology is readily available, handwork is sometimes taken for granted, hidden or viewed with suspicion by outsiders, without fully understanding the benefits of engaging in such mindful activity. Younger women face challenges of trying to fit into a hobby subculture that is stereotypically reserved for older women (45 years and older). In-person and online qualitative research with 32 young women leisure crafters (aged 18–44 years) attest to some of the difficulties of trying to engage in time- and labour-intensive creative activities. In this research, we demonstrate that young women rely on both traditional and new ways of learning creativity; they resist consumer culture to learn handcrafting practices; they have to negotiate space and time to engage in craft; and they find themselves defending their choices of handcrafting as young women.
Knotty cartographies: Augmenting everyday looking practices of craft and race
Authors: Melo Marijel 
Published: September 2018

Abstract
This article examines the disruption of looking and seeing behaviours pertaining to everyday engagements with race and domestic crafts. The notion of the ‘everyday’ derives from Philomena Essed’s approach to analysing racism, a framework that makes visible the veiled manifestations of racial and ethnic inequalities pervasive within societal discourses and practices. Essed’s idea of the ‘everyday’ emphasizes the invisibility of everyday racism. This idea can be extended to domestic crafts: both are perceived as inconsequential, apolitical and ordinary. Despite its innocuous demeanour, everyday racism has material consequences that continue to perpetuate racial inequalities at a systemic level. This article maps out the socio-political impacts of racism vis-à-vis domestic craft. It traces these impacts theoretically. In addition, the author has conceived a visual representation of everyday racism in the form of a macramé wall hanging and augmented reality (AR) technologies in order to offer the viewer a medium for reflection on the socio-political implications of the ‘everydayness’ of racism.
Showtime’s Dexter: The horror of being (non)human
Authors: Keetley Dawn 
Published: September 2018

Abstract
Showtime’s Dexter exemplifies the ‘nonhuman turn’ manifest as horror. It dramatizes, in its serial killer protagonist, the profound interconnectedness of the human and the nonhuman as well as a nonhuman ‘agency’ that undercuts the already limited power of humans to direct their own lives. It does so by consistently highlighting Dexter Morgan’s own determining nonhuman part, which he calls his ‘monster’, his ‘dark passenger’, his ‘shadow self’ – all terms that mark an anonymous ‘it’ and the threat it poses to the ‘human’ Dexter desperately wants to be. The series refuses, though, to define Dexter’s impersonal monstrousness as his alone, as a part of only his past or only his brain – or even, in the end, as a ‘monster’ that is in any way separate from the ‘human’. Dexter’s personal ‘dark passenger’, I argue, is shown to be a shared nonhuman life inherent in the condition of being human. This ‘it’ or ‘thing’ is represented in the series in Dexter’s human doubles, in animals, even in the weather. The ‘it’ of Dexter, in short, marks a nonhuman that is both an external and an internal nature and that is manifest precisely as their indistinction. Showtime’s groundbreaking series thus models a new kind of monster, as well as a new form of horror – one that recognizes the nonhuman in the human.
Vision experiences and participation in a New Horizons Band
Authors: Wehr Erin L. , Coffman Don D. 
Published: September 2018

Abstract
New Horizons International Music Association (NHIMA) bands provide opportunities for older adults to learn, or relearn, a band instrument. Musicians have unique circumstances for vision, and older adults have identified vision as a top concern in their musical experiences. This study explores vision correction experiences of older adults participating in NHIMA Bands and the effectiveness of three accommodations.
‘Toward understanding the nature of history and its limitations’: An interview with the American Artist David Schutter
Authors: Mieves Christian 
Published: September 2018

Abstract
In this conversation American painter David Schutter and the author discuss key aspects of Schutter’s work. Schutter (born 1974), whose work makes reference to major European painting collections, explores in his work the relation to tradition and repetition of artistic conventions. His work, presented at ‘Documenta 14’ (2017), often employs strategies of radical limitation of the colour scheme, and restriction of visibility, sometimes blackening out the image plane altogether. This raises questions about the detachment from the referent object, self-reflexivity and the trope of unrepresentable in contemporary painting in the beginning of the twenty-first century. The conversation will further focus on ways Schutter’s work transgresses from a narrow mimetic framework by mitigating in his paintings the difference between original and double and by employing diminished clarity and ambiguity in his work.
‘Painting within itself’: The ‘John Moores Liverpool Exhibition’
Authors: Gee Gabriel N. 
Published: September 2018

Abstract
This article takes at its cue the 1969 decision of the John Moores Liverpool Painting Prize and exhibition to exclude works projecting more than six inches out of the wall. The refusal to include British contemporary pictorial explorations that expanded beyond the frame of the canvas at the time can be seen as a conservative stance. However, it also paved the way for the exhibition’s subsequent showcasing of the specific problems located within the internal space and constraints of the canvas, in an epoch that heralded the medium’s obsolescence. First, we look at the relation between painting and sculpture in the first years of the biannual prize, when an independent sculpture section attested to latent concerns about the international standing of British arts. We then focus on the 1969 John Moores’ exhibition that provides a unique perspective into the radical changes occurring in art practices in Britain at the time. Finally, we evoke a range of pictorial practices displayed at the John Moores in the 1970s, which are described as articulating a turn ‘within itself’, furthering an investigation into a range of specific aesthetic problems posed by the format of the canvas at the time.
Off the clock: Is drag ‘just a job’?
Authors: Crookston Cameron 
Published: September 2018

Abstract
Many contemporary performance scholars and ethnographers define drag as ‘just a job’, a professional identity often presented as incompatible trans identity. However, recent events, such as Facebook’s ‘real names’ issue, and trans drag performer Peppermint’s highly publicized tenure on RuPaul’s Drag Race (2009–present), have put tension on this fairly narrow definition of drag. In this article, I use these recent moments of tension between drag and trans identity as a jumping off point to track the history of the definition of drag as ‘just a job’ and scrutinize the simplicity of this statement. Drawing on the work of trans historian Susan Stryker, theatre historian Laurence Senelick and drag ethnographer Esther Newton, among others, I use both recent and historic moments of convergence and overlap between drag and trans communities to problematize the definition of the two identities as mutually exclusive.
Lesbian chic, femme-ininity and feminist dialogue: Reflecting on The L Word
Authors: Carter Claire 
Published: September 2018

Abstract
Showtime’s The L Word, which aired from 2004–09, attracted a broad audience in part by featuring a caricature of lesbianism that is heteronormatively appealing – femme, white and cosmopolitan. Drawing on queer popular culture and scholarship on The L Word, this article analyses several of the show’s scenes in order to challenge interpretations of the show as geared for the male gaze and of the lesbian chic as un-subversive. Strategic appeal of the lesbian chic ideal seductively brings viewers in, but once there, they encounter moments of feminist dialogue on identity politics, violence against women and representation as well as a queering of dominant representations of femininity.
Trends in the Development of the International Trade Law
Authors: DIACONESCU Amelia 
Published: September 2018

The international trade exchanges and their continuous development imply the existence of certain regulations under the shape of laws, conventions, treaties, legal tools which ensure stability and legal security for the traders and the commercial relationships.
The process to issue cohesive regulations in the matter of the international trade takes place not only in the area of direct relationships between states, but most often under the auspices of international organizations.
Legal Protection Towards Traditional Food Based on Mark and Geographic Indication Law
Authors: PURWANINGSIH Endang , MUSLIKH MUSLIKH , ANISARIZA Nelly Ulfah , RAHMANTO Derta 
Published: September 2018

Traditional food makers should be empowered and their products should be protected. The objectives of this research are to identify and analyze the potential, the prospect, and the legal protection of traditional food (producer and products) to finally attain legal protection and trademark or geographic indication. In this research, the method applied is analytical descriptive qualitative by making use of participatory (PRA) and sociological-juridical approaches. The research findings suggest that so far, instead of working on a bigger cause that is achieving mark/label, traditional food producers are still striving for trademark merely to get market distribution and halal label. It is clear that they need help from related parties considering their economy, sociological humanities (empowerment), and legal aspects (regulation, policy, brand, halal label, consumer protection). Related parties, the Industry and Trade Service, Cooperatives and SME’s, Directorate General of Property Rights and its regional office, the Department of Agriculture, universities, and the traditional food producers association—should work together and take serious measures to pro-actively involve food makers.
ANALISIS KELAYAKAN DAN STRATEGI PENGEMBANGAN WILAYAH DALAM WACANA PEMBENTUKAN DAERAH OTONOM BARU BOGOR TIMUR
Authors: Nurhasanah Aan , Juanda Bambang , Putri Eka Intan Kumala 
Published: September 2018

ABSTRACTBogor District as one of large region and large number of population has any problems related to accesibility and equity welfare. Regional proliferation considered as a way to overcome that problems. The study used scoring method based on PP no. 78 2007 with descriptive analysis, location quotient analysis, and Klassen Tiphology. This study was aimed to analyzed feasibility of regional proliferation and to formulate regional development strategy based on economic potentials in eastern Bogor District region. In general the result showed that eastern Bogor District region appropriate to organize as an autonomous region. High economic potential and fiscal cappacity of eastern Bogor region can be made as main factor to recommended eastern Bogor District region as an autonomous region. Thus, the selected strategies are how to develop backward regions base on leading sector, support primary sector development such as agricultural. Goverment policy is important to optimize natural resources management, spread out infrastructure development mainly to support rural area development. The implication of policy directed base on each region characters such as social, culture, spatial, basic sector. Furthermore regional development analysis can be set base on sub-district region.
Integracja edukacyjna z innej perspektywy
Authors: Dryżałowska Grażyna 
Published: September 2018

Educational Integration changed the social situation of persons with disability starting the sequence of new factors setting assessments for her. Getting to know their interrelationships and conditioning seems significant for current determining laying individuals of the disabled and wider social contexts in area which are accommodating oneself reasons for taking action ill-advised, in consequence faked, for their public integration.
„Racjonalne usprawnienie” w ramach edukacji dzieci i młodzieży z niepełnosprawnością – rozważania na kanwie konwencji o prawach osób niepełnosprawnych Część 1
Authors: Mikrut Adam 
Published: September 2018

The authorities of the Republic of Poland have ratified the Convention on the Rights of Persons with Disabilities and have undertaken the responsibility to implement such changes in the internal law and in social policy which aim at ensuring full and equal enjoyment of all rights and freedoms by people with disabilities and preventing their discrimination in different aspects of life. One of the ways of fulfilling this commitment is described as “reasonable accommodation”. The author of this article has attempted to find manifestations of such activities in the field of school legislation and its practical examples. As a result, it turned out that in the analysed area many solutions are in line with the spirit of the “reasonable accommodation”.