bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling patterns of genetic variation in parasite–host associations: an example with pinworms and Neotropical primates
Authors: Solórzano García Brenda , Melin Amanda D. , Aureli Filippo , Pérez Ponce de León Gerardo 
Published: October 2018

AbstractPatterns of genetic variation among populations can reveal the evolutionary history of species. Pinworm parasites are highly host specific and form strong co-evolutionary associations with their primate hosts. Here, we describe the genetic variation observed in four Trypanoxyuris species infecting different howler and spider monkey subspecies in Central America to determine if historical dispersal processes and speciation in the host could explain the genetic patterns observed in the parasites. Mitochondrial (cox1) and ribosomal (28S) DNA were analysed to assess genetic divergence and phylogenetic history of these parasites. Sequences of the 28S gene were identical within pinworms species regardless of host subspecies. However, phylogenetic analyses, haplotype relationships and genetic divergence with cox1 showed differentiation between pinworm populations according to host subspecies in three of the four Trypanoxyuris species analysed. Haplotype separation between host subspecies was not observed in Trypanoxyuris minutus, nor in Trypanoxyuris atelis from Ateles geoffoyi vellerosus and Ateles geoffoyi yucatanensis. Levels of genetic diversity and divergence in these parasites relate with such estimates reported for their hosts. This study shows how genetic patterns uncovered in parasitic organisms can reflect the host phylogenetic and biogeographic histories.
Moral Enhancement and Moral Freedom: A Critique of the Little Alex Problem
Authors: Danaher John 
Published: October 2018

AbstractA common objection to moral enhancement is that it would undermine our moral freedom and that this is a bad thing because moral freedom is a great good. Michael Hauskeller has defended this view on a couple of occasions using an arresting thought experiment called the “Little Alex” problem. In this chapter, I reconstruct the argument Hauskeller derives from this thought experiment and subject it to critical scrutiny. I claim that the argument ultimately fails because (a) it assumes that moral freedom is an intrinsic good when, in fact, it is more likely to be an axiological catalyst; and (b) there are reasons to think that moral enhancement does not undermine moral freedom.
Retributivism and the Moral Enhancement of Criminals Through Brain Interventions
Authors: Shaw Elizabeth 
Published: October 2018

AbstractThis chapter will focus on the biomedical moral enhancement of offenders – the idea that we could modify offenders’ brains in order to reduce the likelihood that they would engage in immoral, criminal behaviour. Discussions of the permissibility of using biomedical means to address criminal behaviour typically analyse the issues from the perspective of medical ethics, rather than penal theory. However, recently certain theorists have discussed whether brain interventions could be legitimately used for punitive (as opposed to purely therapeutic) purposes. For instance, Jesper Ryberg argues (although he himself is not a retributivist) that there is nothing to prevent retributivists from endorsing brain interventions as a legitimate form of retributive punishment. Legal academics have not yet paid sufficient attention to whether this proposal would be compatible with international human rights law, nor have retributivist philosophers discussed whether their favoured penal theories have the conceptual resources to explain why brain interventions would not be an appropriate method of punishment. This chapter considers whether there is any indication that these interventions are being used at present for punitive purposes and whether this would violate the European Convention on Human Rights. It examines different versions of retributivism and considers which theory is in the best position to challenge the use of brain interventions as a form of punishment. Finally, it considers whether offering these interventions as an alternative to punishment would violate principles of proportionality.
Lone Wolf Terrorists and the Impotence of Moral Enhancement
Authors: Hardcastle Valerie Gray 
Published: October 2018

AbstractIn their recent bookUnfit for the Future, Persson and Savulescu make a heartfelt plea for the increasing necessity of “moral enhancement”, interventions that improve human capacities for moral behaviour.3They argue that, with all the technological advances of the 20thand 21stcenturies, the sheer scope of horror that humans can now potentially wreak on their neighbours or the world is staggering. Hence, we are morally obliged to use interventions at our disposal to prevent such atrocities. However, as we learn more about human behaviour and decision-making, the argument that we are morally obligated to morally enhance our friends, neighbours, or countrymen starts to fall apart. For us to be more moral requires more than sharpening our reasoning capacities so that we can more effectively recognise what is better or increasing personal motivation so that we are more likely to do what is good. It requires that we all agree on what the good is and how to achieve it, and that there are no social, cultural, physical, or psychological impediments that prevent us from recognising the good or acting on it. To illustrate my position, I use the phenomenon of self-radicalised terrorists as a case study. In particular, I focus on how historians, psychologists, sociologists, criminologists, and political scientists understand the process of self-radicalisation, who self-radicalises, and why, and what all this tells us about it should be “treated”. Part of my purpose in working my way through this case study is to demonstrate that many philosophers misunderstand or over-simplify the science behind so-called immoral actions; consequently, their discussions of whether to enhance someone's morality miss their mark.
The Experimental Psychology of Moral Enhancement: We Should If We Could, But We Can't
Authors: Terbeck Sylvia , Francis Kathryn B. 
Published: October 2018

AbstractIn this chapter we will review experimental evidence related to pharmacological moral enhancement. Firstly, we will present our recent study in which we found that a drug called propranolol could change moral judgements. Further research, which also investigated this, found similar results. Secondly, we will discuss the limitations of such approaches, when it comes to the idea of general “human enhancement”. Whilst promising effects on certain moral concepts might be beneficial to the development of theoretical moral psychology, enhancement of human moral behaviour in general – to our current understanding – has more side-effects than intended effects, making it potentially harmful. We give an overview of misconceptions when taking experimental findings beyond the laboratory and discuss the problems and solutions associated with the psychological assessment of moral behaviour. Indeed, how is morality “measured” in psychology, and are those measures reliable?
An Unfit Future: Moral Enhancement and Technological Harm
Authors: Coyne Lewis 
Published: October 2018

AbstractThis essay addresses two aspects of Persson and Savulescu's case for moral enhancement: 1) the precise technological nature of ultimate harm, particularly as it applies to the ecological crisis, and 2) what is at stake in the solution they propose. My claim is that Persson and Savulescu's treatment of both issues is inadequate: the ecological crisis is a more complex phenomenon than they suppose, and more is at stake in moral enhancement than they claim. To make my case I draw on the work of Hans Jonas, who presciently and insightfully dealt with related questions. Jonas’ philosophy unites bioethical, technological, and environmental concerns and so offers a useful contrast to Persson and Savulescu's proposal. If my analysis is correct then we have both practical and principled reasons to be sceptical about the prospect of moral bioenhancement, which I assume, for the sake of argument, to be feasible.1
Psychedelic Moral Enhancement
Authors: Earp Brian D. 
Published: October 2018

AbstractThe moral enhancement (or bioenhancement) debate seems stuck in a dilemma. On the one hand, the more radical proposals, while certainly novel and interesting, seem unlikely to be feasible in practice, or if technically feasible then most likely imprudent. But on the other hand, the more sensible proposals – sensible in the sense of being both practically achievable and more plausibly ethically justifiable – can be rather hard to distinguish from both traditional forms of moral enhancement, such as non-drug-mediated social or moral education, and non-moral forms of bioenhancement, such as smart-drug style cognitive enhancement. In this essay, I argue that bioethicists have paid insufficient attention to an alternative form of moral bioenhancement – or at least a likely candidate – that falls somewhere between these two extremes, namely the (appropriately qualified) use of certain psychedelic drugs.
Reconstruction of Storm‐Time Total Electron Content Using Ionospheric Tomography and Artificial Neural Networks: A Comparative Study Over the African Region
Authors: Uwamahoro Jean Claude , Giday Nigussie M. , Habarulema John Bosco , Katamzi‐Joseph Zama T. , Seemala Gopi Krishna 
Published: October 2018

AbstractThe work presented here aims to evaluate the capabilities of Multi‐Instrument Data Analysis System (MIDAS) compared with artificial neural networks (ANNs) to reconstruct storm‐time total electron content (TEC) over the African low‐latitude and midlatitude regions. For MIDAS, the inversion was done based on the Global Positioning System (GPS) measurements from receiver stations extending from −30∘ to 36∘ in latitude and 30∘ to 44∘ in longitude while for ANNs, individual storm‐time models based on historical GPS data from receivers within the same region covered by MIDAS were used. Based on the minimum Dst index reached during the storm period, moderate (−50 nT
−100 nT), strong (−100 nT
200 nT), and severe (−200 nT
350 nT) storms were used for validation. MIDAS and ANNs results were compared with IRI‐2016 predictions and validated with real GPS TEC observations. A statistical analysis revealed that MIDAS and ANNs provide comparable results in storm‐time TEC reconstruction with average mean absolute errors of 4.81 and 4.18 TECU respectively. However, MIDAS performed better compared to ANNs in following TEC enhancements and depletions as well as short‐term features observed during the selected storm periods. In terms of latitude, it was found that on average, MIDAS performs 13% better than ANNs in the African midlatitude, while ANN model performs 24% better than MIDAS in low latitudes. Furthermore, comparisons with IRI predictions showed that both MIDAS and ANNs produce more accurate estimations of the storm‐time TEC than IRI model.
Near‐Surface Environmentally Forced Changes in the Ross Ice Shelf Observed With Ambient Seismic Noise
Authors: Chaput J. , Aster R. C. , McGrath D. , Baker M. , Anthony R. E. , Gerstoft P. , Bromirski P. , Nyblade A. , Stephen R. A. , Wiens D. A. , Das S. B. , Stevens L. A. 
Published: October 2018

AbstractContinuous seismic observations across the Ross Ice Shelf reveal ubiquitous ambient resonances at frequencies >5 Hz. These firn‐trapped surface wave signals arise through wind and snow bedform interactions coupled with very low velocity structures. Progressive and long‐term spectral changes are associated with surface snow redistribution by wind and with a January 2016 regional melt event. Modeling demonstrates high spectral sensitivity to near‐surface (top several meters) elastic parameters. We propose that spectral peak changes arise from surface snow redistribution in wind events and to velocity drops reflecting snow lattice weakening near 0°C for the melt event. Percolation‐related refrozen layers and layer thinning may also contribute to long‐term spectral changes after the melt event. Single‐station observations are inverted for elastic structure for multiple stations across the ice shelf. High‐frequency ambient noise seismology presents opportunities for continuous assessment of near‐surface ice shelf or other firn environments.
Appreciation of Peer Reviewers for 2017
Authors: Florindo Fabio , Moldwin Mark , Okin Gregory , Robock Alan , Rohling Eelco J. , Halekas Jasper S. 
Published: October 2018

AbstractOn behalf of the authors and readers of Reviews of Geophysics, the American Geophysical Union, and the broader scientific community, the Editors wish to wholeheartedly thank those who reviewed the manuscripts for Reviews of Geophysics in 2017. The journal could not exist without your investment of time and effort, lending your expertise to ensure that the papers published in this journal meet the standards that the research community expects for it. We sincerely appreciate all that you do, and we are very grateful for your willingness and readiness to serve in this role.
Lithospheric Alteration, Intraplate Crustal Deformation, and Topography in Eastern China
Authors: Deng Yangfan , Levandowski Will 
Published: October 2018

AbstractTopography can be directly observed, but what controls topographic variation is not readily known. To investigate a prominent and remarkably consistent along‐trend topographic gradient belt (TGB) in intraplate eastern China and its connection to ongoing deformation and geodynamics, we examine the regional density structure of the crust and mantle lithosphere. We first use S velocities to derive an initial density and then refine the density model by joint inversion of topography and gravity. We use the final density model and receiver functions to strip away topographic contributions from the crust, and we subsequently estimate the thickness of the mantle lithosphere required to satisfy flexural isostasy. Crustal buoyancy overcompensates for the elevation change across the TGB. East of the TGB (eastern north China craton and southeastern south China), the lithosphere is thin (~ 90 km), suggesting that not only the eastern north China craton but also much of the eastern China has experienced lithospheric dismemberment. The TGB behaves as an important contour for the lithospheric thickness, except for the northeast China and Qinling‐Dabie. Proposed refertilization of the altered mantle lithosphere in the east side of TGB would result in even lower lithospheric thickness, while hydration and asthenosphere upwelling have the opposite effect. This systematic calculation gives a regional analysis of eastern China and could be a useful guide for the regions lacking seismic investigations.
Integrated silicon qubit platform with single-spin addressability, exchange control and single-shot singlet-triplet readout
Authors: Fogarty M. A. , Chan K. W. , Hensen B. , Huang W. , Tanttu T. , Yang C. H. , Laucht A. , Veldhorst M. , Hudson F. E. , Itoh K. M. , Culcer D. , Ladd T. D. , Morello A. , Dzurak A. S. 
Published: October 2018

AbstractSilicon quantum dot spin qubits provide a promising platform for large-scale quantum computation because of their compatibility with conventional CMOS manufacturing and the long coherence times accessible using 28Si enriched material. A scalable error-corrected quantum processor, however, will require control of many qubits in parallel, while performing error detection across the constituent qubits. Spin resonance techniques are a convenient path to parallel two-axis control, while Pauli spin blockade can be used to realize local parity measurements for error detection. Despite this, silicon qubit implementations have so far focused on either single-spin resonance control, or control and measurement via voltage-pulse detuning in the two-spin singlet–triplet basis, but not both simultaneously. Here, we demonstrate an integrated device platform incorporating a silicon metal-oxide-semiconductor double quantum dot that is capable of single-spin addressing and control via electron spin resonance, combined with high-fidelity spin readout in the singlet-triplet basis.
Distinct population codes for attention in the absence and presence of visual stimulation
Authors: Snyder Adam C. , Yu Byron M. , Smith Matthew A. 
Published: October 2018

AbstractVisual neurons respond more vigorously to an attended stimulus than an unattended one. How the brain prepares for response gain in anticipation of that stimulus is not well understood. One prominent proposal is that anticipation is characterized by gain-like modulations of spontaneous activity similar to gains in stimulus responses. Here we test an alternative idea: anticipation is characterized by a mixture of both increases and decreases of spontaneous firing rates. Such a strategy would be adaptive as it supports a simple linear scheme for disentangling internal, modulatory signals from external, sensory inputs. We recorded populations of V4 neurons in monkeys performing an attention task, and found that attention states are signaled by different mixtures of neurons across the population in the presence or absence of a stimulus. Our findings support a move from a stimulation-invariant account of anticipation towards a richer view of attentional modulation in a diverse neuronal population.
Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing
Authors: Sheng Chunjie , Yao Chen , Wang Ziyang , Chen Hongyuan , Zhao Yu , Xu Dazhi , Huang Haojie , Huang Wenlin , Chen Shuai 
Published: October 2018

AbstractMaintaining innate immune homeostasis is important for individual health. Npl4 zinc finger (NZF) domain-mediated ubiquitin chain sensing is reported to function in the nuclear factor-kappa B (NF-κB) signal pathway, but the regulatory mechanism remains elusive. Here we show that cyclophilin J (CYPJ), a member of the peptidylprolyl isomerase family, is induced by inflammation. CYPJ interacts with the NZF domain of transform growth factor-β activated kinase 1 binding protein 2 and 3 as well as components of the linear ubiquitin chain assembly complex to block the binding of ubiquitin-chain and negatively regulates NF-κB signaling. Mice with Cypj deficiency are susceptible to lipopolysaccharide and heat-killed Listeria monocytogenes-induced sepsis and dextran sulfate sodium-induced colitis. These findings identify CYPJ as a negative feedback regulator of the NF-κB signaling pathway, and provide insights for understanding the homeostasis of innate immunity.
Scaling and data collapse from local moments in frustrated disordered quantum spin systems
Authors: Kimchi Itamar , Sheckelton John P. , McQueen Tyrel M. , Lee Patrick A. 
Published: October 2018

AbstractRecently measurements on various spin–1/2 quantum magnets such as H3LiIr2O6, LiZn2Mo3O8, ZnCu3(OH)6Cl2 and 1T-TaS2—all described by magnetic frustration and quenched disorder but with no other common relation—nevertheless showed apparently universal scaling features at low temperature. In particular the heat capacity C[H, T] in temperature T and magnetic field H exhibits T/H data collapse reminiscent of scaling near a critical point. Here we propose a theory for this scaling collapse based on an emergent random-singlet regime extended to include spin-orbit coupling and antisymmetric Dzyaloshinskii-Moriya (DM) interactions. We derive the scaling C[H, T]/T ~ H−γFq[T/H] with Fq[x] = xq at small x, with q ∈ {0, 1, 2} an integer exponent whose value depends on spatial symmetries. The agreement with experiments indicates that a fraction of spins form random valence bonds and that these are surrounded by a quantum paramagnetic phase. We also discuss distinct scaling for magnetization with a q-dependent subdominant term enforced by Maxwell’s relations.
Universality of defect-skyrmion interaction profiles
Authors: Lima Fernandes Imara , Bouaziz Juba , Blügel Stefan , Lounis Samir 
Published: October 2018

AbstractMagnetic skyrmions are prime candidates for future spintronic devices. However, incorporating them as information carriers hinges on their interaction with defects ubiquitous in any device. Here we map from first-principles, the energy profile of single skyrmions interacting with single-atom impurities, establishing a generic shape as function of the defect’s electron filling. Depending on their chemical nature, foreign 3d and 4d transition metal adatoms or surface implanted defects can either repel or pin skyrmions in PdFe/Ir(111) thin films, which we relate to the degree of filling of bonding and anti-bonding electronic states inherent to the proximity of the non-collinear magnetic structure. Similarities with key concepts of bond theories in catalysis and surface sciences imbue the universality of the shape of the interaction profile and the potential of predicting its interaction. The resulting fundamental understanding may give guidance for the design of devices with surface implanted defects to generate and control skyrmions.
Encoding of long-term associations through neural unitization in the human medial temporal lobe
Authors: Rey Hernan G. , De Falco Emanuela , Ison Matias J. , Valentin Antonio , Alarcon Gonzalo , Selway Richard , Richardson Mark P. , Quian Quiroga Rodrigo 
Published: October 2018

AbstractBesides decades of research showing the role of the medial temporal lobe (MTL) in memory and the encoding of associations, the neural substrates underlying these functions remain unknown. We identified single neurons in the human MTL that responded to multiple and, in most cases, associated stimuli. We observed that most of these neurons exhibit no differences in their spike and local field potential (LFP) activity associated with the individual response-eliciting stimuli. In addition, LFP responses in the theta band preceded single neuron responses by ~70 ms, with the single trial phase providing fine tuning of the spike response onset. We postulate that the finding of similar neuronal responses to associated items provides a simple and flexible way of encoding memories in the human MTL, increasing the effective capacity for memory storage and successful retrieval.
ZZ-dependent regulation of p62/SQSTM1 in autophagy
Authors: Zhang Yi , Mun Su Ran , Linares Juan F. , Ahn JaeWoo , Towers Christina G. , Ji Chang Hoon , Fitzwalter Brent E. , Holden Michael R. , Mi Wenyi , Shi Xiaobing , Moscat Jorge , Thorburn Andrew , Diaz-Meco Maria T. , Kwon Yong Tae , Kutateladze Tatiana G. 
Published: October 2018

AbstractAutophagic receptor p62 is a critical mediator of cell detoxification, stress response, and metabolic programs and is commonly deregulated in human diseases. The diverse functions of p62 arise from its ability to interact with a large set of ligands, such as arginylated (Nt-R) substrates. Here, we describe the structural mechanism for selective recognition of Nt-R by the ZZ domain of p62 (p62ZZ). We show that binding of p62ZZ to Nt-R substrates stimulates p62 aggregation and macroautophagy and is required for autophagic targeting of p62. p62 is essential for mTORC1 activation in response to arginine, but it is not a direct sensor of free arginine in the mTORC1 pathway. We identified a regulatory linker (RL) region in p62 that binds p62ZZ in vitro and may modulate p62 function. Our findings shed new light on the mechanistic and functional significance of the major cytosolic adaptor protein p62 in two fundamental signaling pathways.