bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contemporary Distribution of High-Grade Prostate Cancer in the Circumstances of Opportunistic Testing
Authors: Stojadinovic Milorad M , Pantic Damjan N , Stojadinovic Miroslav M 
Published: January 2019

Abstract
Screening has dramatically changed the distribution of the mean age, stage and grade of prostate cancer (PCa) at diagnosis. However, regional-level data that characterize contemporary PCa patients are limited. The aim of the study was to ascertain main clinical and pathological characteristics of PCa at the present time in the circumstances of opportunistic testing.
High-grade PCa according to age, serum prostate specific antigen (PSA), volume prostate, PSA density (PSAD), digital rectal examination (DRE) number of positive cores biopsies and the average percentage of cancer in biopsy at diagnosis has been retrospectively evaluated in 100 men with biopsyproven PCa, at Clinical Centre Kragujevac, from September 2016 until September 2017. PCa were stratified according to Gleason score (GS) into low/intermediate-grade (GS ≤ 7) and high-grade (GS ≥ 8). To identify the determinants associated with high-grade PCa, we performed univariate and multivariate logistic regression.
The most prevalent PCa were the low/intermediate-grade (65%), followed by high-grade (35%). The mean age of the patients was 71.5 (range: 56–88) years and median PSA was 14.6 (range: 1.4–935) ng/ml. There were significant differences in age, PSA, PSAD, DRE, number of positive biopsy and average percentage of cancer in biopsy between patients with or without high-grade GS. Logistic analysis demonstrated the PSAD and age have strong prognostic value of high-grade PCa.
In conclusion, our study has shown the worrying frequency of high-grade PCa in the circumstances of opportunistic testing. Older men and higher level of PSAD had a much higher probability of high-grade PCa.
Mesenchymal Stem Cells Attenuate Acute Liver Failure by Promoting Expansion of Regulatory T Cells in an Indoleamine 2,3-Dioxygenase-Dependent Manner
Authors: Miloradovic Dragana , Miloradovic Dragica , Jankovic Marina Gazdic , Markovic Bojana Simovic , Harrell C. Randall , Fellabaum Crissy , Arsenijevic Nebojsa , Lukic Aleksandra , Volarevic Vladislav 
Published: January 2019

Abstract
The influence of mesenchymal stem cells (MSCs) on the phenotype and function of CD4+CD49b+FoxP3- regulatory cells has not been elucidated. We used Concanavalin A (ConA) - and α-galactosylceramide (α-GalCer)-induced acute liver injury to estimate the effects of MSCs on liver-infiltrating CD4+CD49b+FoxP3-regulatory cells. MSCs significantly reduced ConA- and α-GalCer-mediated liver injury in C57BL/6 mice, as demonstrated by biochemical tests, reduced influx of inflammatory CD4+ T cells, and increased presence of CD4+CD49b+FoxP3- regulatory cells in the injured livers. The number of CD4+CD49b+FoxP3-regulatory cells was also significantly increased in α-GalCer-treated mice that received MSC-derived conditioned medium (MSC-CM). The presence of 1-methyltryptophan, a specific inhibitor of indoleamine 2,3-dioxygenase (IDO), in MSC-CM completely abrogated the hepatoprotective eff ect of MSCs and significantly decreased the total number of liver-infiltrated CD4+CD49b+FoxP3- regulatory cells, indicating the crucial importance of MSC-derived IDO for the expansion of CD4+CD49b+FoxP3- regulatory cells and the consequent MSC-dependent attenuation of acute liver injury.
Redox Status in Women with Rheumathoid Arthritis
Authors: Vranic Aleksandra , Antovic Aleksandra , Draginic Nevena , Andjic Marijana , Ravic Marko , Jakovljevic Vladimir , Veselinovic Mirjana 
Published: January 2019

Abstract
The aim of this study was to assess oxidative status and to set baseline characteristics for female population with established rheumatoid arthritis. Total of 42 patients with rheumatoid arthritis and 48 age- and sex-matched controls were included in the study. Clinical examination was performed and assessed disease activity. Peripheral blood samples were used for all the assays. The markers of oxidative stress were assessed, including plasma levels of index of lipid peroxidation – thiobarbituric acid reactive substances, hydrogen peroxide, superoxide anion radical, nitrites and activity of superoxide dismutase, catalase and reduced glutathione levels as anti-oxidant parameters. In the patients group, levels of hydrogen peroxide and index of lipid peroxidation were higher than in controls. Patients with rheumatoid arthritis had decreased su-peroxide dismutase and catalase activity compared to healthy subjects. Interestingly, controls had higher levels of nitrites compared to patients. Patients showed a marked increase in reactive oxygen species formation and lipid peroxidation as well as decrease in the activity of antioxidant defense system leading to oxidative stress which may contribute to tissue and cartilage damage and hence to the chronicity of the disease.
Antitumor Effect of the Chalcone Analogue, (E) -1-(4-Ethoxy-3-Methoxyphenyl) -5- Methylhex-1-En-3-One on HeLa Cell Line
Authors: Lukovic Jovan , Mitrovic Marina , Zelen Ivanka , Čanovic Petar , Zaric Milan , Nikolic Ivana 
Published: January 2019

Abstract
Chalcones represent precursor compounds for flavonoids biosynthesis in plants. Chalcones, 1,3-diaryl-2-propen-1-ones, have unique chemical structure with conjugated double bonds and delocalized π-electron system on both aromatic rings. Various studies have shown that chemical structure of chalcone is responsible for their antitumor effect. In our study, we have examined the antitumor effect of chalcone analogue (E) -1- (4-ethoxy-3-methoxyphenyl) -5-methylhex-1-en-3-one (CH) on HeLa cells. The antitumor efficiency of different CH concentrations was compared to the antitumor effects of dehydrozingerone and cisplatin. The viability of the cells was evaluated using MTT assay; type of the cell death was evaluated by Annexin V-FITC/7-AAD staining using FACS analysis; morphology changes of treated cells were visualized and compared to untreated cells using phase contrast microscopy. The result of our research showed that CH have a stronger antitumor compared to the effect both of dehydrozingerone and cisplatin. Our results indicated that chalcone analogue induced cell death via activation of apoptosis more powerfully compared to the apoptosis induced with dehydrozingerone and cisplatin.
Ten Marathons in Ten Days: Effects on Biochemical Parameters and Redox Balance – Case Report
Authors: Pesic Deniel , Srejovic Ivan , Stefanovic Djordje , Djordjevic Dusica , Cubrilo Dejan , Zivkovic Vladimir 
Published: January 2019

Abstract
Production of free radicals and oxidative damage during physical activity is a topic that is intensively studied and paid a lot of attention, first of all in professional sports. Marathon is categorized as extremely demanding sports discipline, as it induces high energy consumption and also requires special mental self-control. We presented cases of two athletes of different age, who have been on dissimilar level of sports readiness, and also had various approach to physical activity and exercise. During 10 days they ran out 10 marathons, partly on a flat terrain, and partly on hilly, which produced different level of effort in conquering the terrain. Also, both athletes had complex supplementation scheme in order to prevent electrolyte imbalance and excessive production of free radicals. Blood samples were taken in the morning and immediately after the end of the marathon. Measured oxidative stress biomarkers changed without a noticeable pattern, but these changes did not vary greatly among themselves. Catalase activity in both marathon runners was higher after marathon almost after every race for 10 days. On the other hand, amount of reduced glutathione was lower after marathon in both athletes in the same manner. Based on the obtained results we can conclude that adequate supplementation could have crucial role in prevention of oxidative damage.
Cystic Lesions of Anterior Mediastinum: Case Report
Authors: Lukovic Ana , Arsenijevic Milos , Milisavljevic Slobodan , Stojkovic Dragan , Mrvic Stanko , Radovanovic Dragce 
Published: January 2019

Abstract
Cystic lesions of the mediastinum are uncommon, comprising 12% to 18% of all primary mediastinal tumors and unless they attain a large size and cause compressive symptoms, these tumors are generally asymptomatic and are discovered incidentally upon radiologic investigation of some other condition.
We present in this paper a case of cystic lesions of the mediastinum in a 70-year-old male patient who underwent a surgery for mediastinal mass removal. Histopathology report had shown it was the case of mature cystic teratoma of anterior mediastinum.
Based on a review of the literature, as well as our experience, we conclude that best treatment for cystic lesions of anterior mediastinum is complete surgical resection if possible.
Effect of Behavioural Interventions for Obesity Prevention in Pregnancy on the Adequacy of Gestational Weight Gain and Retention: Metabolic Health of Indian Women
Authors: Pawalia Alka , Кulandaivelan Sivachidambaram , Savant Satya , Yadav Vikram Singh 
Published: January 2019

Abstract
The aim of this study was to measure the adequacy of gestational weight gain (GWG) in Indian women using various behavioural interventions during pregnancy, which primarily aim to observe the effects on obesity markers and weight retention.
In this experimental study, one hundred and forty pregnant women underwent interventions in 5 groups, control (C), diet (D), home exercise (HE), supervised exercise (SE) and supervised exercise with diet (SED), from pregnancy through delivery with 2 months follow-up post-delivery. The outcome measures were GWG and baby birth weight.
A one-way ANOVA indicated no differences in the mean GWG between groups (12.39±4.71 kg, p=0.947). The control group had the most (50%) and both the supervised exercise groups had the fewest (32%) women who gained above the recommended GWG, followed by the diet group (33.3%). The D and HE groups had the most women who gained within the GWG range, while both the SE and SED groups had the most women who gained below the GWG range. However, these results did not affect the birth weight between the groups (mean 2.96 kg±0.40, p=0.203). In women with normal BMIs, (18.5-22.9 kg/m2), the diet group had the most effective maintenance of adequate GWG, with 15%, 55%, and 30% of the women gaining above, within, and below the recommended GWG, respectively. The SE and SED groups had the least postpartum weight retention (PPWR) at 2 months, followed by the HM, D and C groups; i.e., the results showed a trend in the desired direction clinically, although they were not statistically significant (p=0.12).
Supervised exercise can be effectively used as a pregnancy intervention to prevent excess GWG in Indian women. Diet counselling was found to be the next best intervention in combination with exercise, as well as for women with normal BMI.
PENGARUH IKLIM ORGANISASI TERHADAP KOMITMEN ORGANISASIONAL DAN RETENSI PEGAWAI KONTRAK DI BAPPEDA LITBANG PROVINSI BALI
Authors: Cahyadi Meliana Kurniawati , Utama I Wayan Mudiartha 
Published: January 2019

Retensi adalah elemen penting dari pendekatan organisasi. Setiap organisasi hendaknya berupaya mempertahankan karyawannya terutama karyawan yang memiliki nilai penting bagi organisasi. Mempertahankan bakat profesional terbaik adalah praktek sangat penting bagi organisasi seperti mengeliminasi rekrutmen, seleksi dan mengurangi biaya dari pergantian mereka, dan menjaga kontinuitas sesuai bidang keahlian mereka. Penelitian ini bertujuan untuk mengetahui pengaruh iklim organisasi terhadap komitmen organisasional dan retensi pegawai kontrak di Bappeda Litbang Provinsi Bali dengan menggunakan 66 orang sebagai responden penelitian. Teknik penentuan sampel yang digunakan dalam penelitian ini adalah menggunakan teknik sensus. Pengumpulan data dilakukan melalui wawancara dan kuesioner. Teknik analisis data yang digunakan pada penelitian ini adalah path analysis yang diolah menggunakan software SPSS. Hasil yang diperoleh dalam penelitian ini menunjukkan bahwa iklim organisasi memiliki hubungan yang positif dan signifikan terhadap komitmen organisasi, iklim organisasi memiliki hubungan yang positif dan signifikan terhadap retensi dan iklim organisasi memiliki hubungan yang positif dan signifikan terhadap retensi.
Kata kunci : iklim organisasi, komitmen organisasional, retensi.
PENGARUH KEPUTUSAN INVESTASI, KEPUTUSAN PENDANAAN DAN KEBIJAKAN DIVIDEN TERHADAP NILAI PERUSAHAAN FOOD AND BEVERAGES
Authors: Utami Asri Pawestri Setyo , Darmayanti Ni Putu Ayu 
Published: January 2019

Companies that want to maximize the value of the company, will take some decisions such as investment decisions, dividend policies, and funding decisions. The purpose of this study is to explain the effect of investment decisions, funding decisions, and dividend policy on the value of food and beverages companies listed on the Indonesia Stock Exchange. The samples used in this study were selected in saturation sampling. Secondary data obtained then selected based on predetermined criteria, then obtained as many as 13 sample during period of year 2013-2016. Data analysis technique used is multiple linear regression analysis. The results showed that investment decisions, funding decisions, and dividend policies have a positive and significant impact on the value of food and beverages companies. The suggestion that can be given is to pay more attention to internal factors of the company. These variables can be used as a reference to establish a strategy in increasing the value of the company. Good corporate value shows the level of good corporate financial health so as to make the value of the company will be increased and in demand by investors.
Keywords: Investment Decision, Fund Decision, Dividend Policy, Corporate Value
The Meanings of "Kanashii" and "Kurushii" from the Perspective of Kanji Writing and Their Uses in Japanese Sentences
Authors: Indra Pradhana Ngurah 
Published: January 2019

This research is entitled "The Meanings Of "Kanashii" And "Kurushii" From The Perspective Of Kanji Writing And Their Uses In Japanese Sentences." This title was chosen as a research topic because it is still rare to conduct their research that analyzes the meaning of adjectives, especially the synonymous adjective by reviewing the formation of kanji. There are not many people know, especially for Japanese language learners and is very interesting to stimulate new research variations. us with the exact aspects of their meaning with a review of the formation of kanji. The method used in this study consists of a method of referring to data collection by tapping techniques. In the next practice, this tapping technique is followed by advanced techniques in the form of techniques of recording and techniques of uninvolved conversation technique. The technique of note is to record things that are considered important. The method used to analyze the data is the method of agih (distribution method). The last stage is the presentation of the results of analysis by using formal and informal methods. It is done so that the readers understand the research results more clearly. The theory used in this research is about kanji and its formation, synonym theory, and theory of contextual meaning. With these theories study are that the readers are given differences in the use of two synonyms words in Japanese with cultural nuances they have.
Problems and ways of improving the efficiency of surgical treatment of hiatal herniae
Authors: Vasilevskii D. I. , Dvoretskii S. Iu. , Tarbaev I. S. , Akhmatov A. M. 
Published: January 2019

The objectiveof the study is to consider the main problems and to define the ways to improve the efficiency of surgical treatment of hiatal herniae.Material and methods.518 patients were operated, the plasty of hiatal hernia – posterior cruroraphy – was carried out in 191 (26.9%) of patients, the prosthetic materials via the method «mesh-reinforced» were used in 327 (63.1%) of patients.Results. The general surgical complications were noted in 43 (8.3 %) patients, the delayed side effects were in 118 (22.8 %) patients, relapse of hiatal hernia were in 27 (5.9 %) patients.Conclusion.The high frequency of relapses remains the main problem in surgery of hiatal hernia.
Diskriminierung von Senioren – Fakten über und Wege für das würdige altern
Authors: Morciniec Piotr 
Published: January 2019

Obecne stulecie przedstawiane jest często jako wiek starzenia się. Nieproporcjonalne zwiększanie się grupy ludzi starych, do prawie jednej czwartej społeczeństwa niesie ze sobą nie tylko dumę z osiągnięć medycyny przedłużającej życie, lecz także negatywne trendy społeczne. Postępujące procesy, które zostały już określone jako „desolidaryzacja międzygeneracyjna”, znajdują swój wyraz także w bardzo negatywnych zjawiskach, wśród których na znaczenia nabiera dyskryminacja osób starszych. Bazujące na stereotypach i uprzedzeniach negatywne nastawienie do najstarszej części społeczeństwa budzi niepokój i domaga się poszukiwania dróg wyjścia. W niniejszym opracowaniu na podstawie analizy polskojęzycznej literatury fachowej starano się uporządkować przyczyny i konteksty takich negatywnych odniesień do seniorów, wskazano najistotniejsze obszary dyskryminacyjne, aby na koniec zapytać o możliwe wyjścia z sytuacji nierówności społecznej, której doświadczają ludzie starzy. Przesłanie tekstu pozostaje pozytywne, gdyż potrzeba poszukiwać nowych dróg solidarności i dialogu międzygeneracyjnego, pamiętając że priorytetowym zadaniem pozostaje wzmocnienie silnej rodziny, która pozostaje najbardziej sprawdzona ostoją godności osób najsłabszych, do których seniorzy niewątpliwie należą.
ТЕОРЕТИКО-МЕТОДОЛОГІЧНИЙ АНАЛІЗ ФЕНОМЕНУ ЗАДОВОЛЕНОСТІ ЯКІСТЮ ЖИТТЯМ ЯК УМОВИ РОЗВИТКУ ПРОФЕСІЙНОЇ Я-КОНЦЕПЦІЇ ОСОБИСТОСТІ
Authors: Kliuiko Lesia 
Published: January 2019

У статті розглянуто задоволеність якістю життя як одну з головних умов розвитку професійної Я-концепції особистості. Задоволеність якістю життя визначається, насамперед, досягнутими цілями, подоланими труднощами, змінами, що відбуваються в особистому й професійному житті, а на рівень задоволеності життям впливає весь комплекс характеристик, пов’язаних із невротизмом. Наше проаналізовано останні дослідження, що стосуються феномену задоволеності життям, у світовій і вітчизняній літературі, висвітлено проблеми формування та розвитку поняття Я-концепції в наукових працях учених-психологів. Я-концепція у внутрішньому світі людини та її самосві­домості зокрема – це важлива структурна складова частина психологічної самоорганізації, що виконує функцію передумови й наслідку ефективності соціальної взаємодії і якості життя в цілому та виявляється як відносно усталена, динамічна й певною мірою усвідомлена система уявлень особи про саму себе.
Також презентовано теоретичне дослідження задоволеності життям як однієї з умов розвитку професійної Я-концепції особистості та визначено, що задоволеність життям є складним психологічним поняттям. Виділено різні компоненти й фактори задоволеності якістю життя. Я-концепція формується за етапами соціалізації та має індивідуально-природне спричинення й виникає в процесі розгортання соціальної взаємодії як результат її культурного розвитку, а відтак є відносно стійким і водночас піддатливим до внутрішніх коливань та змін психічним новоутворенням. Окрім того, Я-концепцію описують із боку змісту й характеру уявлень про себе, складності та диференційованості цих уявлень, їх суб’єктивної важливості для особистості, а також внутрішньої цілісності й послідовності, узгодженості, стійкості в часі.
A Team Production Theory of Canadian Corporate Law
Authors: Ben-Ishai Stephanie 
Published: January 2019

The article applies the Team Production Theorydeveloped by American corporate law scholars, Margaret Blair and Lynn Stout, to argue that Canadian corporate law's understanding of public corporations that are not controlled by a single shareholder or group of shareholders reflects a director primacy norm rather than a shareholder primacy norm. Canadian corporate law provides that directors of such public corporations with widely-held share ownership and voting rights are free from direct control by any corporate stakeholders. A potential departing point for Canadian corporate law. the oppression remedy, continues to develop to deal with extra-legal advantages rooted primarily in unequal power relations among corporate stakeholders. However, in its current and predicted future applications, the oppression remedy does not provide any given stakeholder group with an ability to dominate the boards of public corporations and obviate the director primacy norm. The article suggests that because the director primacy norm accurately describes Canadian corporate law, further consideration needs to be given to corporate law's relative relevance in dictating how Canadian corporations currently operate.
The Legal Framework for Acquiring Water Entitlements from Existing Users
Authors: Bankes Nigel 
Published: January 2019

This article provides a detailed analysis of the legal framework under Alberta's <i>Water Act</i> and <i>IrrigationDistricts Act</i>, pursuant to which a person may acquire an entitlement to water from an existing user. The first part of the article covers both the agreement to assign water as well as the licence transfer procedure introduced in the new <i>Water Act</i>. The second part of the article deals with the creation of derivative rights to water by irrigation districts including rural water licence use agreements and water conveyance agreements. The article also examines the temporary and permanent assignments of rights to irrigable acreage within irrigation districts.
In Praise of Phenomenology
Authors: Sheets-Johnstone Maxine 
Published: January 2019

A critical assessment of Merleau-Ponty’s conception of phenomenology highlights singular differences between Husserl’s phenomenological methodology and existential analysis, between epistemology and ontology, and between essential and individualistic perspectives. When we duly follow the rigorous phenomenological methodology described by Husserl, we are confronted with the challenge of making the familiar strange and with the challenge of languaging experience. In making the familiar strange, we do not immediately have words to describe what is present, but must let the experience of the strange resonate for some time, and even then, must return to it many times over to pinpoint its aspects, character, or quality in descriptively exacting ways. Moreover as Husserl points out, language can seduce us into thinking we know when we do not know. The methodology thus highlights the import of being true to the truths of experience, and in doing so, authenticates the basic value of a phenomenological methodology to the human sciences.