bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-in-man study of a novel everolimus-coated balloon for the treatment of coronary in-stent restenosis
Authors: Alfonso Fernando , Shaburishvili Tamaz , Farah Bruno , Gogorishvili Ikrali , Monsegu Jacques , Baranauskas Arvydas , Bressollette Erwan , Shaburishvili George , Cuesta Javier , Rivero Fernando , Moreno Raul , Sabate Manel 
Published: November 2024

Background
Treatment of patients with in-stent restenosis (ISR) remains challenging. In this setting the use of drug-coated balloons (DCB) represents an attractive approach to avoid adding another metal layer to the coronary wall.

Aims
The Chansu Vascular Technologies (CVT)-ISR trial aimed to evaluate the safety and efficacy of a novel everolimus-DCB (CVT-DCB) using a new coating formulation and crystalline everolimus.

Methods
The CVT-ISR trial was a prospective, multicenter, open, single-arm, first-in-man (FIM) study. A total of 51 patients (mean age 69.2 years, 74.5% male) with single ISR coronary lesions (≤24 mm in length) were enrolled at nine sites in Europe.

Results
The primary safety endpoint, freedom from target lesion failure (TLF) at 180 days, was 92.2%, with the lower bound of the 95% confidence interval (81.1%), above the protocol-defined objective performance criterion (OPC) (65% for conventional balloon angioplasty, P < 0.05). At 1 year freedom from TLF was 90.2%. The primary efficacy endpoint, in-stent late lumen loss at 180 days (evaluated in a predefined subgroup of 25 patients scheduled for late angiography), was 0.40 mm (median 0.30 mm), lower than the protocol-defined OPC of the plain balloon angioplasty historical control (0.80 mm, P < 0.001).

Conclusion
This FIM study demonstrated the superior efficacy of the new everolimus CVT-DCB compared with conventional balloon angioplasty in the treatment of patients with ISR.

Clinical trials registration
NCT05731700.
Bronchodilator responsiveness in chronic obstructive pulmonary disease: prevalence, significance, and clinical implications
Authors: Aggarwal Ashutosh N. , Agarwal Ritesh 
Published: November 2024

Purpose of review
Bronchodilator responsiveness (BDR) is often considered a key feature distinguishing asthma from chronic obstructive pulmonary disease (COPD). However, recent evidence suggests that BDR alone may not be a reliable discriminator between these conditions. There is still no consensus on BDR definitions and testing protocols. Additionally, it remains unclear whether BDR is linked to a specific COPD phenotype or influences treatment responses. Our review of recent literature attempts to clarify some of these issues.

Recent findings
A significant proportion of COPD patients demonstrate BDR, but the variability in testing procedures and definitions makes it challenging to draw any definite conclusion. There is no evident association between BDR and specific COPD characteristics. A few studies suggest that BDR may be associated with marginally better treatment response and disease outcomes in COPD. The impact of recent changes in BDR definitions on clinical practice remains to be fully understood.

Summary
There is still no clear, clinically relevant threshold to define BDR. BDR is an unreliable discriminator to differentiate asthma from COPD and is not consistently linked to any specific COPD phenotype, treatment response, or disease outcomes. Further research is needed to refine the definitions and implications of BDR in COPD.
The breadth and impact of the Global Lipids Genetics Consortium
Authors: Dron Jacqueline S. , Natarajan Pradeep , Peloso Gina M. 
Published: November 2024

Purpose of review
This review highlights contributions of the Global Lipids Genetics Consortium (GLGC) in advancing the understanding of the genetic etiology of blood lipid traits, including total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and non-HDL cholesterol. We emphasize the consortium's collaborative efforts, discoveries related to lipid and lipoprotein biology, methodological advancements, and utilization in areas extending beyond lipid research.

Recent findings
The GLGC has identified over 923 genomic loci associated with lipid traits through genome-wide association studies (GWASs), involving more than 1.65 million individuals from globally diverse populations. Many loci have been functionally validated by individuals inside and outside the GLGC community. Recent GLGC studies show increased population diversity enhances variant discovery, fine-mapping of causal loci, and polygenic score prediction for blood lipid levels. Moreover, publicly available GWAS summary statistics have facilitated the exploration of lipid-related genetic influences on cardiovascular and noncardiovascular diseases, with implications for therapeutic development and drug repurposing.

Summary
The GLGC has significantly advanced the understanding of the genetic basis of lipid levels and serves as the leading resource of GWAS summary statistics for these traits. Continued collaboration will be critical to further understand lipid and lipoprotein biology through large-scale genetic assessments in diverse populations.
The Relationship Between Point-of-Care Tool Use and Nurses’ Self-Efficacy
Authors: Knowles Amy L. , Neal Penelope , Pell Christopher , Bloom Lindsey , Brown Julie 
Published: November 2024

Background:
Despite benefits of evidence-based practice (EBP), barriers exist that prevent translation of evidence to point of care.

Purpose:
The purpose of this study was to examine types of EBP resources used by nurses, and correlate EBP resource use with nurse’s self-efficacy.

Method:
A descriptive correlational design was used.

Results:
A total of 52 nurses participated. A wide range of EBP resources were used including hospital policies/procedures, education provided by an employer, and internet searches. Participants had high levels of self-efficacy with nursing skills. Nurses with lower self-efficacy were more likely to use colleagues as an EBP resource and had fewer years of nursing experience.

Conclusions:
Nurses reported gaining information from a range of sources; unfortunately, not all sources were evidence-based. Removing barriers to EBP resource use and providing access to concise recommendations to nurses may improve use of EBP at the point of care.
Utilization of Neurology and Allied Health Services by People With Parkinson’s Disease in Israel: A Retrospective Observational Study
Authors: Naamneh-Abuelhija Badera , Kafri Michal , Kestenbaum Meir , Shadmi Efrat , Mintz Igor , Shved Sarit , Giveon Shmuel , Kamah Sharon , Yogev-Seligmann Galit 
Published: November 2024

Background:
Sustainable utilization of neurology and allied health professions’ services is pivotal for effective management of Parkinson disease (PD) and is correlated with positive health-related outcomes.

Objectives:
(1) To describe the utilization of neurology and allied health services by people with PD (PwP); (2) to explore the associations between demographic and structural variables and utilization; and (3) to test associations between utilization and unplanned hospitalizations.

Methods:
A retrospective observational cohort study of 1761 PwP in the years 2014-2019 was conducted. Utilization of neurology and allied health services was mapped. Regression models were examined to test associations between demographic and structural variables, utilization of neurology and physical therapy (PT), and unplanned hospitalizations.

Results:
Approximately 50% of the study population utilized neurology services. Utilization rate of allied health services ranged between 0% and 19%. The likelihood of utilizing neurology services increased for people with extended health insurance and people with more years since diagnosis and decreased for women and for people living at a great distance from a neurology service. The likelihood of utilizing PT increased for Jews and people with extended health insurance and decreased for people with more years since diagnosis and for people living at a great distance from a PT service. Among patients with fewer years since diagnosis (<5 years), those who utilized PT had a higher likelihood of unplanned hospitalization.

Conclusions:
Neurology and allied health services are underutilized by PwP, particularly by minorities and women. Policymakers should take proactive steps to increase utilization.

Video Abstract available
for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A496)
The role of lymphatic vessels in cardiac injury and repair
Authors: Wang Taiwei , Fan Xuanxuan , Gao Chaoyue , Wu Ye , Luo Lin , Shu Yue , Zhao Jiahui , Zhen Ke , Liu Huirong , Zhang Suli , Liu Yisi 
Published: November 2024

Abstract
The cardiac lymphatic system plays a vital role in maintaining interstitial fluid balance, immune cell homeostasis, and overall cardiac health. Despite its importance, the involvement of cardiac lymphatics in heart disease has only recently garnered significant research attention. This review explores the structural, molecular, and functional characteristics of the cardiac lymphatic network and its role in cardiac injury and the subsequent repair process, including conditions such as myocardial infarction, ischemia-reperfusion injury, infective endocarditis, atherosclerosis, heart failure, and atrial fibrillation. Studies demonstrate that cardiac lymphatics facilitate the clearance of interstitial fluid, proteins, and immune cells, contributing to inflammation resolution and tissue repair. However, dysfunctions in the lymphatic system can exacerbate pathologic processes, leading to myocardial edema, fibrosis, and cardiac remodeling. Emerging evidence suggests that targeted modulation of lymphangiogenesis and lymphatic function may offer new therapeutic avenues for treating cardiovascular diseases. This review provides a comprehensive understanding of the cardiac lymphatic system’s contribution to cardiac injury and repair, aiming to lay the groundwork for future research and therapeutic development in this burgeoning field.
Prediction of interpersonal personality for people living with HIV using machine learning
Authors: Han Shuyu , Yang Xianxia , Jia Changli , Wang Xiaomeng , Chen Yundi , Xie Xin , Hu Yan , Zhang Yukun , Yang Zhongfang , Zhang Lili , Wang Zhiwen 
Published: November 2024

Abstract

Background:
The ultimate goals of HIV treatment and care have changed from viral suppression to improving quality of life due to the development of antiretroviral therapy (ART). Social functioning is an important aspect of quality of life, which is also associated with many health outcomes. Interpersonal personality influences individuals’ tendencies and preferences in the process of interpersonal communication. This study aims to develop and validate a prediction model of interpersonal personality for people living with HIV (PLWH) using machine learning.

Methods:
We recruited participants from 7 HIV/AIDS-designated hospitals in China from 2022 to 2023. This study included 3040 participants and collected 16 demographic and clinical variables according to the social determinants of health (SDOH) framework. A standard questionnaire was used to collect data on interpersonal personality. Five machine learning algorithms were applied to make predictions: random forest (RF), extreme gradient boosting (XGBoost), gradient boosting machine (GBM), bidirectional recurrent neural network (BRNN), and neural network (NNet).

Results:
XGBoost was found to have the best prediction performance, with a root mean square error (RMSE) value of 2.53. We used XGBoost to analyze the 16 variables and found that the top 5 most heavily weighted variables were CD4+ T-cell count, age, months since ART, months since HIV diagnosis, and viral load, suggesting that these 5 variables had the greatest impact on PLWH’s interpersonal personality. The performance of the XGBoost model was evaluated, and significant correlations (P<0.05) were found between the measured and predicted scores.

Conclusions:
The interpersonal personality of PLWH can be predicted by demographic and clinical variables, with high importance weights for HIV-related clinical variables. It may be influenced and shaped by HIV infection, which highlights the profound impact of HIV infection on PLWH even in the future functional cure era. Medical professionals should be aware that interventions can be designed to buffer the impact of HIV infection on the interpersonal personality of PLWH. Subjective needs and preferences that are influenced by interpersonal personality are important for the development of social support interventions for PLWH.
Electroconvulsive therapy research in BRICS and G7 countries: A bibliometric analysis from 2005 to 2024
Authors: Guo Qinghua , Wang Yong , Guo Libo , Shang Shaomei 
Published: November 2024

Abstract

Objectives:
Over the last two decades, global mental health challenges have significantly increased, drawing attention to electroconvulsive therapy (ECT) as a potential remedy for serious mental conditions. This article aimed to examine the patterns of collaboration networks, publication dynamics, and key areas of ECT research in BRICS and G7 nations.

Methods:
Through bibliometric evaluation, this study analyzed publication volume, collaboration networks, keyword burst detection, and citation patterns of 3,595 articles published between 2005 and 2024, from the Web of Science Core Collection database, published between 2005 and 2024. The analysis focused on outputs from BRICS and G7 countries and limited to publications in English. The descriptive analytics, network visualization, and burst detection techniques were used.

Results:
Findings showed a notable surge in ECT-focused publications post-2015, signaling a heightened worldwide interest in mental health. Analysis of keyword trends identified three pivotal stages in ECT research evolution: initial concerns over ECT’s efficacy and safety, broadening of its application scope, and the recent refinement of treatment methodologies alongside the formulation of international guidelines. Examination of collaborative networks underscored dense interconnections among G7 nations, in stark contrast to the more localized collaborations within BRICS.

Conclusions:
This study provides critical insights into the global research landscape of electroconvulsive therapy (ECT) among BRICS and G7 nations. The findings emphasize the growing importance of ECT as a treatment for severe mental disorders, particularly in light of the ongoing global mental health crisis. Future studies is needed to compare ECT with emerging therapies, personalize treatment outcomes, and expand to underrepresented populations to further enhance the efficacy and accessibility of ECT worldwide.
Perspectives on Public Health Department Accreditation: Lessons Learned From Ohio’s Accreditation Mandate
Authors: Oberly Tonni , Singh Simone R. , Bush Stevens Amy , Blair-Ackison Robin , Sheeran Anna , Lang Britt 
Published: November 2024

Context:
Ohio is the only state that requires local health departments (LHDs) to be accredited by the Public Health Accreditation Board (PHAB). As of May 2024, 80% of Ohio’s 111 LHDs achieved accreditation, making Ohio the state with the highest proportion of accredited LHDs in the country.

Objectives:
This study examined the experience of public health accreditation in Ohio including the perceived value of PHAB accreditation for LHDs. It also explored the extent to which perspectives on the value of mandatory accreditation differed between state and local health officials.

Design:
Data for this study was obtained from 5 focus group interviews with 41 participants, representing state and local perspectives on PHAB accreditation in Ohio. Interviews were recorded, transcribed, and coded using inductive and deductive coding for a thematic analysis.

Results:
Focus group participants outlined numerous advantages that accreditation has brought to their organizations. Commonly cited benefits include enhancements in quality improvement and performance management, strengthened collaborations and partnerships, improved communications, and optimized resource use. Challenges in achieving accreditation involved the financial expenses associated with the process and constraints on staffing resources. State officials generally expressed positive views on the accreditation mandate, perceiving it as a pathway to modernize the public health system and ensure consistency in service delivery across communities. In contrast, local stakeholders offered more nuanced perspectives and voiced concerns about the intentions behind the mandate.

Conclusions:
The experience of health officials in Ohio offers lessons for both PHAB and officials in other states working to increase public health department accreditation levels. Successful implementation of accreditation mandates requires trust between state and local partners, open communication, and clarity of purpose. Moreover, attaining accreditation necessitates substantial resources, including technical assistance, financial support, and a robust workforce.
Tenofovir Disoproxil Fumarate/Emtricitabine Prophylaxis Has No Effect on Bone Mineral Density and Bone Mineral Content in African Breastfeeding Women Receiving Pre-Exposure Prophylaxis for HIV
Authors: Kistan Gaysheen , Sebitloane Motshedisi , Lombard Carl , Godlwana Zukiswa , Desmond Alicia C. , Clark Richard , Rooney James F. , Gray Glenda , Moodley Dhayendre 
Published: November 2024

Background:
Tenofovir disoproxil fumarate (TDF) when used as pre-exposure prophylaxis (PrEP) during pregnancy is considered safe overall, however, there is insufficient evidence of its effect on maternal bone. We compared bone mineral density (BMD) and bone mineral content (BMC) at the lumbar spine (LS) and hip of African breastfeeding women exposed and not exposed to TDF-containing PrEP in a randomized control trial (RCT).

Methods:
This is a secondary data analysis of an RCT where pregnant women were randomized to initiating PrEP during pregnancy or delayed initiation of PrEP until breastfeeding cessation. BMD and BMC at the LS and hip were measured using dual-energy x-ray absorptiometry (DXA) at 6, 26, 50, and 74 weeks postpartum. In an exploratory analysis, BMD at the hip and LS were evaluated against varying tenofovir levels during pregnancy.

Results:
Of 300 women in the RCT who had a DXA at 6 weeks postpartum, 102 (66%) women in the Immediate PrEP arm and 105 (72%) in the Delayed PrEP arm had a 74-week DXA scan. Adjusting for breastfeeding duration and body mass index, there were no significant differences in BMD or BMC at the hip and LS between treatment arms. There was no consistent dose–effect of tenofovir diphosphate detected during pregnancy on BMD at the hip (P = 0.231) or the LS (P = 0.277).

Conclusions:
After adjusting for breastfeeding and body mass index, tenofovir disoproxil fumarate when given as oral PrEP during pregnancy had no deleterious effect on BMD and BMC at the hip and LS of African breastfeeding women.
Outcome and Renal Safety of PSMA-Targeted Radioligand Therapy in mCRPC Patients With Preexisting Impaired Renal Function
Authors: Bastian Moritz B. , Sieben Maike , Burgard Caroline , Blickle Arne , Speicher Tilman , Bartholomä Mark , Maus Stephan , Petto Sven , Schaefer-Schuler Andrea , Ezziddin Samer , Rosar Florian 
Published: November 2024

Purpose
This study aims to evaluate the outcome and renal safety of prostate-specific membrane antigen (PSMA)–radioligand therapy (RLT) in patients with metastatic castration-resistant prostate carcinoma (mCRPC) and preexisting renal impairment.

Methods
Ninety-four patients with preexisting renal impairment were included in this retrospective analysis. Inclusion criterion was a glomerular filtration rate (GFR) of ≤60 mL/min (equivalent to Common Terminology Criteria of Adverse Events [CTCAE] ≥2). Patients underwent either [177Lu]Lu-PSMA-617 RLT exclusively (n = 63) or additionally in augmented manner with [225Ac]Ac-PSMA-617 (n = 31). The median number of administered cycles was 4 (range, 1–16 cycles) with a mean cumulative activity of 29.9 ± 16.3 GBq (range, 6.9–87.2 GBq) [177Lu]Lu-PSMA-617. Main blood parameters of interest were creatinine, cystatin C, and the respective GFR values. Changes in GFR were categorized according to CTCAE v5.0.

Results
In the entire cohort, mean best PSA response was −56.73% ± 45.71%, with 63 of 94 patients (67%) experiencing partial remission. The median progression-free survival and overall survival were 6.7 and 14.1 months, respectively. Under PSMA-RLT, 5 of 94 patients (5.3%) improved to CTCAE grade 0, and 23 of 94 (24.5%) improved to CTCAE grade 1. Three of 94 patients (3.2%) improved from CTCAE grade 3 to grade 2, and only 5 of 94 (5.3%) decreased. The majority (58/94 [61.7%]) of patients stayed stable in terms of CTCAE grading.

Conclusion
PSMA-RLT is an effective and safe treatment in mCRPC patients with preexisting impaired renal function (CTCAE ≥2). In daily clinical practice, patients should not be categorically excluded from enrolment to PSMA-RLT due to renal impairment.
Dual-Tracer 18F-FDG and 68Ga-PSMA PET/CT Imaging of Heterogeneous Phenotypes of Metastatic Castration-Resistant Prostate Cancer for Predicting Response to Novel Hormone Therapy
Authors: Bian Linjie , Li Panli , Wang Xiangwei , Zuo Yan , Liu Xuwei , Bai Liyan , Lei Jialiang , Guo Haoyao , Hu Silong , Liu Chang , Song Shaoli 
Published: November 2024

Purpose
This study evaluated interlesion heterogeneity in prostate cancer using dual-tracer imaging (PSMA and FDG) and explored its predictive value for novel hormone therapy (NHT).

Patients and Methods
A total of 205 prostate cancer patients (23 biochemical recurrences, 68 metastatic castration-sensitive prostate cancers, 114 metastatic castration-resistant prostate cancers [mCRPC]) who underwent dual 18F-FDG and 68Ga-PSMA PET/CT imaging were retrospectively analyzed. Among them, 62 mCRPC patients received NHT. Patients were classified into 3 groups: PSMA+FDG−, PSMA+FDG+, and PSMA-FDG+. SUVratio, the ratio of PSMA-SUVmax to FDG-SUVmax, was evaluated for its predictive value on progression-free survival (PFS).

Results
The proportion of PSMA+FDG− patients decreased from biochemical recurrence to mCRPC stages, whereas FDG+ cases increased significantly (P = 0.001). In the NHT cohort, group 3 (PSMA-FDG+) had significantly shorter median PFS than group 1 (133 vs 497 days; P = 0.027). In group 2, patients with a high SUVratio had better median PFS than those with a low SUVratio (368 vs 147 days; P = 0.031).

Conclusions
Dual-tracer imaging reveals interlesion heterogeneity in prostate cancer, and SUVratio may help predict early response to NHT.
Incidental Detection of Prostatic Lesion on 18F-FDG PET/CT and 68Ga-PSMA-11 PET/CT Leading to Diagnosis of Second Primary Prostatic Adenocarcinoma in a Patient of Differentiated Thyroid Cancer
Authors: Gondhane Abhay Indrasingh , Parghane Rahul V. , Basu Sandip 
Published: November 2024

Abstract
Second primary malignancies are being increasingly detected in the setting of thyroid cancer, because of adoption of the advanced imaging modalities including PET/CT. Herein, we present a patient of papillary thyroid carcinoma who initially underwent total thyroidectomy with bilateral neck dissection followed by 131I radioactive iodine therapy. A prostatic lesion was incidentally detected on 18F-FDG PET/CT scan, which was intensely 18F-FDG avid and also showed intense focal 68Ga–prostate-specific membrane antigen (PSMA) uptake on 68Ga-PSMA-11 PET/CT scan. This led to the diagnosis of prostatic adenocarcinoma as a second primary cancer in this patient with papillary thyroid carcinoma.