bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal variations in the seminal plasma composition of male goats
Authors: Dias Julio Cesar Oliveira , Veloso Cristina Mattos , Santos Madriano Christilis da Rocha Santos , De Oliveira Carlos Thiago Santos Alvim Mendes , Silveira Camila Oliveira , Iglesias Erick , Furtado Pedro Henrique , Donzele Rita Flávia Miranda de Oliveira 
Published: April 2019

Este estudo avaliou as variações mensais proteicas e bioquímicas no plasma seminal de bodes da raça Alpina criados em clima tropical. A avaliação da motilidade progressiva de espermatozóides foi realizada no sêmen fresco e descongelado, e a avaliação da funcionalidade da membrana após a descongelação. Após 12 meses, o plasma seminal foi submetido a eletroforese em gel de SDS-poliacrilamida a 10 e 14%, em paralelo com as análises dos seus parâmetros bioquímicos. No gel de poliacrilamida a 10% foram identificadas 22 bandas proteicas (25-181 kDa), enquanto que no gel de 14%, foram identificadas 16 bandas proteicas (5,7-165 kDa). As frações de proteínas de 5,7 e 34,3-34,5 kDa mostraram um perfil que variou de acordo com a sazonalidade reprodutiva dos bodes, com o aumento da produção ocorrendo durante a estação reprodutiva. Na análise dos parâmetros bioquímicos, as concentrações de cálcio, fósforo, e colesterol também mostraram variação sazonal. No entanto, a análise da motilidade progressiva, bem como a funcionalidade de membrana não alteraram. Estes resultados indicam que alterações nos perfis proteico e bioquímico do plasma seminal durante o ano, não alterou a qualidade do sêmen fresco e descongelado de bodes Alpinos em clima tropical.
AVALIAÇÃO DO CRESCIMENTO DE MILHO (Zea mays L.) SOBRE O EFEITO DE DIFERENTES DOSES DE BIOSSÓLIDO EM LATOSSOLO VERMELHO-AMARELO NO CERRADO PIAUIENSE
Authors: Costa Tancio Gutier Ailan , Cunha Laécio Miranda , Iwata Bruna de Freitas , Coelho Juliana Vogado , Santos João Gabriel Pereira dos , Clementino Gleide Ellen dos Santos 
Published: April 2019

O milho (Zea mays L.) está entre as espécies mais cultivadas no mundo, em que são cultivados cerca de 140 milhões de hectares, contribuindo para a produção de aproximadamente 610 milhões de toneladas de grãos. A produção do Zea mays L, está condicionado pelo uso de fontes de adubação, e esta, sendo realizada de forma adequada contribui para os índices de produção desta cultura, sendo a adubação química a mais utilizada. No entanto, formas alternativas de inserção de nutrientes no solo vêm sendo testadas, sendo a aplicação de efluentes considerada uma alternativa viável em muitos casos. Assim, dentre os efluentes que apresentam este potencial, destaca-se o lodo de esgoto - tido como biossólido – proveniente das estações de tratamento de esgoto doméstico e/ou industrial. Diante disso, o objetivo desse trabalho foi avaliar os efeitos da aplicação do biossólido no crescimento e produtividade do milho (Zea mays L.), em comparação com adubação mineral (NPK) e esterco bovino. O estudo foi realizado no município de Corrente (Piauí), em experimento montado na área do campus do Instituto Federal do Piauí. Para realização do estudo foram delimitadas seis parcelas para implementação do experimento, parcelas essas, dimensionadas em 1m x 1m, adjacentes. Dos tratamentos, três consistiram na aplicação do biossólido, em doses crescentes, sendo eles: de 0 Kg (T1) área testemunha sem adição de adubação, 1 Kg (T2), 2 Kg (T3) e 4 Kg (T4). Os demais tratamentos foram de esterco bovino 200 g (T5) e adubo mineral (NPK) 100g (T6). O plantio do milho foi realizado manualmente, utilizando-se quatro covas com três sementes em cada. O biossólido utilizado no experimento foi proveniente da estação de tratamento de esgoto do município de Corrente após tratamento com a cal virgem. Com os resultados obtidos pôde-se concluir que a aplicação do biossólido atende as necessidades da planta (milho) proporcionando aumento na germinação das sementes, crescimento das plantas, incremento de biomassa seca, e um maior crescimento das espigas com maior produtividade de grãos. Ressultados mais positivos quando comparados à adubação química e a adubação orgânica de referência (esterco bovino). Logo, o biossólido apresenta nutrientes necessários às plantas sendo o mesmo rico em matéria orgânica.
Formation of architectural and planning organization of general education schools with inclusive education
Authors: Kutsevych V. 
Published: April 2019

With the ratification of the United Nations Convention on the Rights of Persons with Disabilities (UN General Assembly Resolution 6/106, adopted at 61 session of the UN General Assembly, 2006), the Law of Ukraine No. 176-VI dated December 13, 2009 approved a number of legislative acts. Thus, the Convention on the Development of Inclusive Education, approved by the order of the Ministry of Education and Science of Ukraine dated 10.10.2010 No. 912 states that inclusive education is a complex process of ensuring equal access to quality education for children with special educational needs by organizing their education in general educational institutions based on the application of personally oriented teaching methods, taking into account the individual peculiarities of educational and cognitive activity of such children.
The solution of the problem of organizing inclusive education in general educational institutions of Ukraine is aimed at fulfilling the provisions of the UN Convention on the Rights of Persons with Disabilities, which led to intensification of scientific research. In this direction, textbooks have been published, methodological recommendations have been developed, scientific articles have been published, defended dissertations.
At the same time, in new school projects, investors and authors of general education institutions often do not envisage the organization of inclusive education, believing that children with special educational needs will not study in these institutions.
First of all, we should note that in Ukraine society is not entirely prepared to solve the problem of organizing inclusive education in secondary schools. For example, not everyone knows that the formation of a class with inclusive education is carried out by the head of a comprehensive educational institution, taking into account educational needs of the population, provided that there is a necessary material and technical and methodological base, appropriate pedagogical staff and premises, in agreement with the relevant education management body.
The article examines the issues of creating equal access for children with special educational needs to quality education by forming a comfortable architectural and planning organization of general educational institutions. Recommendations are given regarding the occupancy of classes with inclusive education, the parameters and areas of the main premises of schools are determined.
The Image of a Woman in Everyday Works of E. Kontratovych
Authors: Cheipesh A. 
Published: April 2019

In the works of E. Kontratovych in the early period and the period of heyday, there are the everyday works, the main character of which is a woman. In the early period (1930–1943), the image of woman plays in the main theme of begging – disadvantaged women, suffered beggars. This is connected with the showing the fate of the Verkhovyna population, which suffered because of the World Economic Crisis of the 1930s. At that time, the artist was also interested in the folklore and mysterious world of the legends and myths of the Carpathians, embodied in the original female types. The works of the early period are executed mainly in the expressionist style, which are characterized by roughness and deformation of the form, dramatic, contrasting colors. A special role was assigned to the landscape, which the artist used as a means of enhancing of the emotional color. In some of the works, the main characters are depicted against the background of ruined houses, bare trees, which increases the sense of tragedy, drama. In others, the landscape is neutral or conditional, which suggests the indifference to the fate of the depicted women. With the beginning of the period of heyday (1944–1990), the range of topics devoted to the life of the Transcarpathian peasantry is expanding considerably. In works, the woman acts in the characted of a mother ("Transcarpathian Madonna"), a reaper, a laundress, a harvester. Launched in the 1930s, a series devoted to the fate of women, became more significant in the 1960s–1970s. The works of the period of heyday are mainly executed in the style of "Carpathian" expressionism. Forms of objects are molded with a soft brush stroke, the rhythm of the composition is built on the motion of brushwork, rounded lines. The artist prefers rich, vivid color that enhances the life-affirming emotions. The landscape also takes on an uplifting mood. Regardless of color, stylistic preferences and compositional changes, E. Kontratovych's works, devoted to the image of women are designed to glorify a woman as a mother and a worker, to create her idealized image for inspiration and admiration.
Özkıyım Girişimi Nedeni ile Çocuk Acil Servise Başvuran 18 Yaş Altı Hastaların Değerlendirilmesi
Authors: ELMAS Bahri , ULUĞ Nujin 
Published: April 2019

Amaç: Bu çalışmada öz kıyım girişimi nedeniyle çocuk acil servise başvuran olguların sosyodemografik özellikleri, öz kıyım girişim yöntemleri ve risk etkenlerinin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntem: Çalışmamızda Ekim 2014-Nisan 2017 tarihleri arasında Sakarya Üniversitesi Tıp Fakültesi Eğitim ve Araştırma Hastanesi Çocuk Acil Servisi bölümüne intihar girişimi nedeniyle başvuran ve “İntihar Girişimleri Kayıt Formu” doldurulan 18 yaş altı 383 olgunun kayıtları cinsiyet, yaş, yerleşim bölgesi, eğitim durumu, intihar girişimi için kullanılan yöntem ve tetikleyici faktörler, girişim sayısı, psikiyatrik tanı, takip ve tedavi öyküleri açısından retrospektif olarak değerlendirilmiştir.Bulgular: Çalışmaya alınan 383 vakadan 330(%86.2)’u kız ve vakaların yaş ortancası 15(12-18) yıl bulundu. Vakaların çoğunluğu lise öğrencisi idi (%56.9). Vakaların tamamının ilaç-toksik madde ile öz kıyım girişiminde bulunduğu görüldü. Vakalardan 326(%85.1)’sının ilk defa, 57(%14.9)’sinin ise birden çok öz kıyım girişiminde bulunduğu izlendi. Öz kıyım nedenlerinin en sık ailesel sorunlar(%60.6), ardından gelişim dönemi sorunları (%18.5) olduğu gözlendi. 27(%7) vakanın daha önce psikiyatrik bir hastalık tanısı bulunurken, 356(%93) vakanın psikiyatrik bir tanısının olmadığı görüldü. Vakaların çoğunluğunun şehir merkezinde yaşadığı görüldü (%92.4) . Öz kıyım girişimlerinin en sık (%30.5) ilkbahar mevsiminde olduğu gözlendi. Başvuru saatlerine göre hastaların en sık 20.00-24.00 arasında başvurduğu tespit edildi.Sonuç: Sonuç olarak, hayatı tehdit eden bir problem olan suisid girişimi ile ilgili risk faktörleri bir bütün olarak ele alınarak, çocuklara uygun koruyucu, destekleyici ve tedavi edici yaklaşımlar açısından değerlendirilmelidir.
Les cueillettes commerciales au Québec : capter la diversité socio-environnementale
Authors: Doyon Sabrina 
Published: April 2019

La cueillette commerciale d’espèces sauvages est une activité dont la popularité est en croissance au Québec. Si les produits cueillis sont de mieux en mieux connus, on ne peut en dire autant de l’activité elle-même et des cueilleurs. Qui sont-ils ? Comment accèdent-ils aux ressources ? Quels défis rencontrent-ils ? Cet article aborde ces questions par le truchement de la diversité des pratiques déployées. Les notions « d’accumulation par captation » et « d’espaces péricapitalistes », permettant d’explorer les différentes configurations socio-environnementales et économiques des activités de cueillette, guident l’exploration. Pour ce faire, l’article brossera un portrait du développement des activités de cueillette au Québec et présentera des caractéristiques des cueilleurs, de leurs savoirs, de leurs pratiques, des territoires qu’ils explorent et de l’organisation de leur travail.
« Faire la ferraille » en banlieue parisienne : glaner, bricoler et transgresser
Authors: Florin Bénédicte , Garret Pascal 
Published: April 2019

Les « ferraillous » sont des hommes, et parfois des femmes, qui collectent dans les rues les métaux abandonnés ou les « encombrants » qui, triés et bricolés, seront revendus aux grossistes. De la sorte, cette économie grise alimente les filières mondialisées et lucratives de la métallurgie. Boulot de la débrouille, glaner la ferraille est le fait de personnes en situation de marginalité sociale et économique qui réalisent leurs activités dans des marges urbaines, autant d'espaces ressources pour ces cueilleurs contemporains. Les entretiens réalisés dans les banlieues de Paris témoignent que, par leurs pratiques et savoir-faire, les ferraillous s'affranchissent des obstacles que leur situation personnelle et leur activité, plus ou moins tolérée, leur imposent. S’y révèle aussi une hiérarchie en leur sein ainsi que la place spécifique attribuée à la figure du Rom.
Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans
Authors: Tam Jenny M. , Reedy Jennifer L. , Lukason Daniel P. , Kuna Sunnie G. , Acharya Mridu , Khan Nida S. , Negoro Paige E. , Xu Shuying , Ward Rebecca A. , Feldman Michael B. , Dutko Richard A. , Jeffery Jane B. , Sokolovska Anna , Wivagg Carl N. , Lassen Kara G. , Le Naour François , Matzaraki Vasiliki , Garner Ethan C. , Xavier Ramnik J. , Kumar Vinod , van de Veerdonk Frank L. , Netea Mihai G. , Miranti Cindy K. , Mansour Michael K. , Vyas Jatin M. 
Published: April 2019

Abstract
Tetraspanins are a family of proteins possessing four transmembrane domains that help in lateral organization of plasma membrane proteins. These proteins interact with each other as well as other receptors and signaling proteins, resulting in functional complexes called “tetraspanin microdomains.” Tetraspanins, including CD82, play an essential role in the pathogenesis of fungal infections. Dectin-1, a receptor for the fungal cell wall carbohydrate β-1,3-glucan, is vital to host defense against fungal infections. The current study identifies a novel association between tetraspanin CD82 and Dectin-1 on the plasma membrane of Candida albicans–containing phagosomes independent of phagocytic ability. Deletion of CD82 in mice resulted in diminished fungicidal activity, increased C. albicans viability within macrophages, and decreased cytokine production (TNF-α, IL-1β) at both mRNA and protein level in macrophages. Additionally, CD82 organized Dectin-1 clustering in the phagocytic cup. Deletion of CD82 modulates Dectin-1 signaling, resulting in a reduction of Src and Syk phosphorylation and reactive oxygen species production. CD82 knockout mice were more susceptible to C. albicans as compared with wild-type mice. Furthermore, patient C. albicans–induced cytokine production was influenced by two human CD82 single nucleotide polymorphisms, whereas an additional CD82 single nucleotide polymorphism increased the risk for candidemia independent of cytokine production. Together, these data demonstrate that CD82 organizes the proper assembly of Dectin-1 signaling machinery in response to C. albicans.
Measuring Thymic Clonal Deletion at the Population Level
Authors: Breed Elise R. , Watanabe Masashi , Hogquist Kristin A. 
Published: April 2019

Abstract
Clonal deletion of T cells specific for self-antigens in the thymus has been widely studied, primarily by approaches that focus on a single receptor (using TCR transgenes) or a single specificity (using peptide-MHC tetramers). However, less is known about clonal deletion at the population level. In this article, we report an assay that measures cleaved caspase 3 to define clonal deletion at the population level. This assay distinguishes clonal deletion from apoptotic events caused by neglect and approximates the anatomic site of deletion using CCR7. This approach showed that 78% of clonal deletion events occur in the cortex in mice. Medullary deletion events were detected at both the semimature and mature stages, although mature events were associated with failed regulatory T cell induction. Using this assay, we showed that bone marrow–derived APC drive approximately half of deletion events at both stages. We also found that both cortical and medullary deletion rely heavily on CD28 costimulation. These findings demonstrate a useful strategy for studying clonal deletion within the polyclonal repertoire.
Anterior Cruciate Ligament Injury Risk in Sport: A Systematic Review and Meta-Analysis of Injury Incidence by Sex and Sport Classification
Authors: Montalvo Alicia M. , Schneider Daniel K. , Webster Kate E. , Yut Laura , Galloway Marc T. , Heidt Robert S. , Kaeding Christopher C. , Kremcheck Timothy E. , Magnussen Robert A. , Parikh Shital N. , Stanfield Denver T , Wall Eric J. , Myer Gregory D. 
Published: April 2019

Objective
To evaluate sex differences in incidence rates (IRs) of anterior cruciate ligament (ACL) injury by sport type (collision, contact, limited contact, and noncontact).

Data Sources
A systematic review was performed using the electronic databases PubMed (1969–January 20, 2017) and EBSCOhost (CINAHL, SPORTDiscus; 1969–January 20, 2017) and the search terms anterior cruciate ligament AND injury AND (incidence OR prevalence OR epidemiology).

Study Selection
Studies were included if they provided the number of ACL injuries and the number of athlete-exposures (AEs) by sex or enough information to allow the number of ACL injuries by sex to be calculated. Studies were excluded if they were analyses of previously reported data or were not written in English.

Data Extraction
Data on sport classification, number of ACL injuries by sex, person-time in AEs for each sex, year of publication, sport, sport type, and level of play were extracted for analysis.

Data Synthesis
We conducted IR and IR ratio (IRR) meta-analyses, weighted for study size and calculated. Female and male athletes had similar ACL injury IRs for the following sport types: collision (2.10/10 000 versus 1.12/10 000 AEs, IRR = 1.14, P = .63), limited contact (0.71/10 000 versus 0.29/10 000 AEs, IRR = 1.21, P = .77), and noncontact (0.36/10 000 versus 0.21/10 000 AEs, IRR = 1.49, P = .22) sports. For contact sports, female athletes had a greater risk of injury than male athletes did (1.88/10 000 versus 0.87/10 000 AEs, IRR = 3.00, P &lt; .001). Gymnastics and obstacle-course races were outliers with respect to IR, so we created a sport category of fixed-object, high-impact rotational landing (HIRL). For this sport type, female athletes had a greater risk of ACL injury than male athletes did (4.80/10 000 versus 1.75/10 000 AEs, IRR = 5.51, P &lt; .001), and the overall IRs of ACL injury were greater than all IRs in all other sport categories.

Conclusions
Fixed-object HIRL sports had the highest IRs of ACL injury for both sexes. Female athletes were at greater risk of ACL injury than male athletes in contact and fixed-object HIRL sports.
Deficits in Quadriceps Force Control After Anterior Cruciate Ligament Injury: Potential Central Mechanisms
Authors: Ward Sarah H. , Perraton Luke , Bennell Kim , Pietrosimone Brian , Bryant Adam L. 
Published: April 2019

ContextPoor quadriceps force control has been observed after anterior cruciate ligament (ACL) reconstruction but has not been examined after ACL injury. Whether adaptations within the central nervous system are contributing to these impairments is unknown.ObjectiveTo examine quadriceps force control in individuals who had sustained a recent ACL injury and determine the associations between cortical excitability and quadriceps force control in these individuals.DesignCross-sectional study.SettingResearch laboratory.Patients or Other ParticipantsEighteen individuals with a recent unilateral ACL injury (6 women, 12 men; age = 29.6 ± 8.4 years, height = 1.74 ± 0.07 m, mass = 76.0 ± 10.4 kg, time postinjury = 69.5 ± 42.5 days) and 18 uninjured individuals (6 women, 12 men; age = 29.2 ± 6.8 years, height = 1.79 ± 0.07 m, mass = 79.0 ± 8.4 kg) serving as controls participated.Main Outcome Measure(s)Quadriceps force control was quantified as the root mean square error between the quadriceps force and target force during a cyclical force-matching task. Cortical excitability was measured as the active motor threshold and cortical silent period. Outcome measures were determined bilaterally in a single testing session. Group and limb differences in quadriceps force control were assessed using mixed analyses of variance (2 × 2). Pearson product moment correlations were performed between quadriceps force control and cortical excitability in individuals with an ACL injury.ResultsIndividuals with an ACL injury exhibited greater total force-matching error with their involved (standardized mean difference [SMD] = 0.8) and uninvolved (SMD = 0.9) limbs than did controls (F1,27 = 11.347, P = .03). During the period of descending force, individuals with an ACL injury demonstrated greater error using their involved (SMD = 0.8) and uninvolved (SMD = 0.8) limbs than uninjured individuals (F1,27 = 4.941, P = .04). Greater force-matching error was not associated with any cortical excitability measures (P &gt; .05).ConclusionsQuadriceps force control was impaired bilaterally after recent ACL injury but was not associated with selected measures of cortical excitability. The findings highlight a need to incorporate submaximal-force control tasks into rehabilitation and “prehabilitation,” as the deficits were present before surgery.
Role of anti-tissue transglutaminase IgA+IgG antibodies in detection of potential celiac disease in patients with type 1 diabetes
Authors: Kaur Navchetan , Minz Ranjana W. , Bhadada Sanjay K. , Saikia Biman , Dayal Devi , Anand Shashi , Joshi Neha , Singh Jagdeep , Thapa Babu R. , Kochhar Rakesh K. , Vaiphei Kim 
Published: April 2019

Background & objectives:
Celiac disease (CD) can exist in various forms in type 1 diabetes (T1D) patients and can remain undetected, leading to severe complications. This study was aimed to evaluate five commercially available anti-tissue transglutaminase (tTG) ELISA kits with distinct formats for the detection of CD and potential CD in T1D patients. Clinical and demographic profiles of the patients with different disease subsets were also studied.

Methods:
Fifty T1D patients with classical and non-classical symptoms of CD and 100 T1D patients without any symptoms of CD were included in this study. Anti-tTG autoantibody levels were estimated by five ELISA kits followed by histological examination of duodenal biopsy. HLA DQ2-DQ8 and DRB1-DQB1 typing was done, and serum levels for transforming growth factor (TGF)-β1 were also estimated.

Results:
Assay format detecting anti-tTG IgA antibodies against recombinant antigens along with neopeptides of gliadin was most efficient in the detection of CD in symptomatic patients, and assay format detecting IgA+IgG helped in the detection of potential CD in asymptomatic T1D patients. These findings were supported by histological examination and human leucocyte antigen analysis. Patients with potential CD were found to have markedly deranged glycaemic control parameters and also had significantly raised serum levels of TGF-β1, (P<0.05) compared to T1D patients.

Interpretation & conclusions:
Potential CD can be frequently seen in T1D patients. This can be attributed to the dietary patterns prevalent in the subcontinent and the genetic basis of the disease. Anti-tTG IgA+IgG antibodies can be useful in the detection of these potential CD cases in T1D patients. Early intervention with gluten-free diet can be considered in these patients for better disease management.