bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Global POLAR program: Calmangafodipir used on top of modified FOLFOX6 (5-FU/FA and oxaliplatin) to prevent chemotherapy induced peripheral neuropathy (CIPN).
Authors: Pfeiffer Per , Qvortrup Camilla , Muro Kei , Lustberg Maryam B. , Nagahama Fumiko , Sonehara Yusuke , Bengtson Marie Helene , Nittve Malin , Sonesson Christian , Carlsson Carl Stefan 
Published: January 2019

TPS722 Background: Oxaliplatin (OXA), is approved in combination with 5-FU/FA (5-fluorouracil/folinic acid; FOLFOX) for metastatic as well as in adjuvant colo-rectal cancer (CRC) treatment. CIPN is a common adverse event, after OXA treatment. The incidence of chronic CIPN is approximately 15% after a cumulative dose of 780 to 850 mg/m² and 50% after a cumulative dose of 1170 mg/m². OXA induced neuropathy, results in greatly reduced nitrated manganese superoxide dismutase (MnSOD) activity. Treatment with a superoxide dismutase mimetic, such as calmangafodipir (CAL), prevents and reverses oxaliplatin-induced neuropathies. This has been demonstrated in the PLIANT study (Glimelius et al. 2017). Methods: The POLAR program is a phase III, multicenter, placebo (PLC)-controlled program of CAL to prevent CIPN, initiated in US, Europe and Asia: POLAR A patients with CRC, treatment of patients with stage III or high-risk stage II who are indicated for adjuvant modified FOLFOX6 (mFOLFOX6) chemotherapy for up to 6 months, randomized in a 1:1 ratio, each arm n = 140: A: CAL (5 µmol/kg) + mFOLFOX6 chemotherapy B: PLC + mFOLFOX6 chemotherapy POLAR M Patients with metastatic colorectal cancer (mCRC), who are indicated for first-line mFOLFOX6 chemotherapy for at least 3 months, without any pre-planned treatment breaks and will be randomized in a 1:1:1 ratio, each arm n = 140: A: CAL (2 µmol/kg) + mFOLFOX6 chemotherapy B: CAL (5 µmol/kg) + mFOLFOX6 chemotherapy C: PLC + mFOLFOX6 chemotherapy. Primary objective is to compare CAL versus PLC with respect to the proportion of patients with moderate or severe chronic CIPN. The primary endpoint is; patient reported symptoms as proportion of patients scoring 3 or 4 in at least 1 of the first 4 items of the FACT/GOG-NTX-13 (i.e., FACT/GOG-NTX-4), targeting numbness, tingling or discomfort in hands and/or feet, assessed 9 months after the first dose of chemotherapy. In addition to conventional safety endpoints, Progressive Free Survival and Overall Survival are assessed in the POLAR M study. In the POLAR A study Disease Free Survival is one additional safety endpoint assessed. Results are expected during second half of 2020. Clinical trial information: NCT03654729.
CO.28: Neoadjuvant Chemotherapy, Excision and Observation (NEO) for early rectal cancer.
Authors: Kennecke Hagen F. , Brown Carl J , Auer Rebecca , Drolet Sebastien , Eng Cathy , Gordon Vallerie Lynn , Hochman David J , Moloo Hussein , Wei Alice C , Chan Kelvin , Montenegro Alexander , Loree Jonathan M. , Tu Dongsheng , Jonker Derek J. 
Published: January 2019

TPS724 Background: CO.28 is a phase II study which aims to determine if patients with stage I/II rectal cancer can be treated with induction chemotherapy (FOLFOX/CAPOX) and organ-preserving transanal microsurgery. Prior studies have explored the use of pelvic chemoradiation followed by transanal microsurgery as a means to increase organ preservation. However, pre-operative radiation may have acute and prolonged impacts such as wound complications and adverse on sphincter, sexual and urinary function. Moreover, patients who develop recurrence following this strategy are difficult to salvage as re-irradiation is not usually an option. There is virtually no prospective experience of neoadjuvant FOLFOX/CAPOX chemotherapy and excision for early rectal tumors. Methods: The primary objective is to determine the rate of organ preservation and the trial will be successful if more than 65% of patients avoid a formal rectal resection. In this two-staged phase II trial, patients are eligible if they have clinical N0 and T1-T3a/bN0M0 rectal tumors and no pathologic high risk features. After 6 cycles of q2weekly FOLFOX or 4 cycles of CAPOX, rectal endoscopy and pelvic MRI are repeated and if there is evidence of tumor response, patients proceed to tumor excision by Transanal Endoscopic Microsurgery (TEMS) or Transanal Minimally Invasive Surgery (TAMIS). It is required that participating surgeons have a minimum experience of 20 TEMS/TAMIS procedures and they are asked to submit an unedited video for central review. Pathologic ypT0 or ypT1N0 tumors are assigned to observation while ypT2+ or any ypN+ tumors are treated with radical surgery and total mesorectal excision (TME). Pre-operative pelvic radiation is suggested only for ypT3+ or node positive tumors. Endoscopic and cross-sectional imaging is repeated every 4-6 months for 36 months. Circulating tumor DNA (ctDNA) will be correlated with tumor response and relapse. A total of 58 patients will be accrued. Study Progress: The study was activated in Canada in late 2017 and at select US Cancer Centers in 2018, with total accrual to date of 4 patients. (NCT03259035) Clinical trial information: NCT03259035.
Morphogenesis of neurons and glia within an epithelium
Authors: Low Isabel I. C. , Williams Claire R. , Chong Megan K. , McLachlan Ian G. , Wierbowski Bradley M. , Kolotuev Irina , Heiman Maxwell G. 
Published: January 2019

ABSTRACT
To sense the outside world, some neurons protrude across epithelia, the cellular barriers that line every surface of our bodies. To study the morphogenesis of such neurons, we examined the C. elegans amphid, in which dendrites protrude through a glial channel at the nose. During development, amphid dendrites extend by attaching to the nose via DYF-7, a type of protein typically found in epithelial apical ECM. Here, we show that amphid neurons and glia exhibit epithelial properties, including tight junctions and apical-basal polarity, and develop in a manner resembling other epithelia. We find that DYF-7 is a fibril-forming apical ECM component that promotes formation of the tube-shaped glial channel, reminiscent of roles for apical ECM in other narrow epithelial tubes. We also identify a requirement for FRM-2, a homolog of EPBL15/moe/Yurt that promotes epithelial integrity in other systems. Finally, we show that other environmentally exposed neurons share a requirement for DYF-7. Together, our results suggest that these neurons and glia can be viewed as part of an epithelium continuous with the skin, and are shaped by mechanisms shared with other epithelia.
Study protocol for the Anesthesiology Control Tower—Feedback Alerts to Supplement Treatments (ACTFAST-3) trial: a pilot randomized controlled trial in intraoperative telemedicine
Authors: Gregory Stephen , Murray-Torres Teresa M. , Fritz Bradley A. , Ben Abdallah Arbi , Helsten Daniel L. , Wildes Troy S. , Sharma Anshuman , Avidan Michael S. ,   ACTFAST Study Group
Published: January 2019

Background: Each year, over 300 million people undergo surgical procedures worldwide. Despite efforts to improve outcomes, postoperative morbidity and mortality are common. Many patients experience complications as a result of either medical error or failure to adhere to established clinical practice guidelines. This protocol describes a clinical trial comparing a telemedicine-based decision support system, the Anesthesiology Control Tower (ACT), with enhanced standard intraoperative care. Methods: This study is a pragmatic, comparative effectiveness trial that will randomize approximately 12,000 adult surgical patients on an operating room (OR) level to a control or to an intervention group. All OR clinicians will have access to decision support software within the OR as a part of enhanced standard intraoperative care. The ACT will monitor patients in both groups and will provide additional support to the clinicians assigned to intervention ORs. Primary outcomes include blood glucose management and temperature management. Secondary outcomes will include surrogate, clinical, and economic outcomes, such as incidence of intraoperative hypotension, postoperative respiratory compromise, acute kidney injury, delirium, and volatile anesthetic utilization. Ethics and dissemination: The ACTFAST-3 study has been approved by the Human Resource Protection Office (HRPO) at Washington University in St. Louis and is registered at clinicaltrials.gov (NCT02830126). Recruitment for this protocol began in April 2017 and will end in December 2018. Dissemination of the findings of this study will occur via presentations at academic conferences, journal publications, and educational materials.
Predição da definição da escolha vocacional a partir de variáveis familiares
Authors: Ambiel Rodolfo , Ferraz Adriana , Pereira Edson , Simões Natália , Silva Jasiele 
Published: January 2019

Na adolescência, a participação da família é considerada como um importante fator no processo de escolha profissional. Objetivou-se a investigação do nível de predição dos estilos parentais, congruência entre pais e filhos e autoeficácia dos filhos em relação à definição da escolha vocacional numa amostra de 140 alunos doensino médio. As idades variaram de 15 a 18 anos (M = 16,14), sendo a maioria do sexo feminino (58%). Os instrumentos utilizados foram: Questionário sociodemográfico, Escala de Responsividade e Exigência Parental-EREP, Escala de Congruência entre Pais e Filhos sobre Escolha Profissional-ECPF-EP e Escala de Autoeficácia para Escolha Profissional-EAE-EP. Por meio da análise de regressão hierárquica, os instrumentos foram agrupados em três blocos. O modelo formado a partir do último bloco foi o melhor, sendo que as variáveis responsividade materna, congruência complementar e autoeficácia para busca de informação profissionalprática foram os preditores significativos. Sugere-se a continuidade dos estudos.Palavras-chave: autoeficácia para escolha profissional, relações familiares, estilos parentais, orientação profissional
Un suelo que no deja de moverse. Temporalidades no-humanas de Nuno Ramos
Authors: Giorgi Gabriel 
Published: January 2019

Perhaps some of the most significant investigations in contemporary literature and art from Brazil revolve around the question of temporality , the threshold between the living and the dead and the ways in which conflicting temporalities and anachronism articulate a critique of the present. In this context, Nuno Ramos’ installations and writings, working on the unstable terrain between the living and the dead, the organic and the inorganic, the fossilized and the spectral, represent a decisive intervention. In Ramos’ works memory is never entirely human; it is irreducible to the domain of subjectivity nor to the shared narratives of the collective. From books such as Cujo or Junco to the the fossilized matter present in many of his works, the relationship between life and death is both political, technological and non-anthropomorphic —it is, in other words, biopolitical. This paper analyzes the ways in which the configuration of such critical perspective in Nuno Ramos’ work interrogates and reformulates the ways in which temporality and the political interface there where the very notion of life — the bios that articulates the biopolitical— is at stake.
Hindsight is 2020
Authors: Goss David A. 
Published: January 2019

This paper gives an account of the history of the Optometric Historical Society (OHS), based on material in its quarterly publication, variously named Newsletter of the Optometric Historical Society (1970-1991), Hindsight (1992-2006), and Hindsight: Journal of Optometry History (2007-present). Operated as an independent organization for many years from its founding in 1969, the OHS became a part of Optometry Cares – The AOA Foundation in 2012. In addition to its publication, now totaling more than 3,300 pages since its inception, the OHS has also held meetings referred to as Reminisce-ins or Blasts from the Past, in association with annual meetings of the American Optometric Association and the American Academy of Optometry. Officers and participants in the OHS have included many significant individuals in optometry.
Keragaman Cendawan Pascapanen pada Umbi Bawang Merah Varietas Bima Brebes
Authors: Dharmaputra Okky Setyawati , Listiyowati Sri , Nurwulansari Ira Zahara 
Published: January 2019

Diversity of Postharvest Fungi on Shallot Bulbs Variety Bima BrebesIn Indonesia, shallot (Allium ascalonicum) is horticultural main commodity after hot pepper. Significant yield losses can be caused by postharvest fungi infection. Research on the diversity of postharvest fungi on shallot bulbs has been conducted in some countries, unfortunately little is done in Indonesia. The study was aimed to obtain information on the diversity of postharvest fungi infecting shallot bulbs variety Bima Brebes from several traditional markets in Bogor City. Shallot bulbs were collected in January and February 2016. The study consisted of fungal isolation from shallot bulbs, fungal pathogenicity test, and identification of pathogenic fungi based on morphological and molecular characteristics. Morphology identification was based on the color of fungal colony, growth pattern, as well as somatic and reproduction structures. Several species of pathogenic fungi were successfully identified from shallot bulbs i.e. Alternaria alternata, Aspergillus niger, Colletotrichum gloeosporioides species complex, Fusarium fujikuroi species complex, F. oxysporum, F. solani, Penicillium citrinum and P. pinophilum. Among these fungi, the highest pathogenicity was shown by C. gloeosporioides species complex.
Numerical Simulation of Gas-Liquid Dispersion in A Stirred Tank Agitated by Punched Rigid-Flexible Impeller
Authors: Gu Deyin , Liu Zuohua , Tao Changyuan , Li Jun , Wang Yundong 
Published: January 2019

Abstract
The hydrodynamics of gas-liquid dispersion process in a stirred tank with rigid impellers, rigid-flexible impellers, and punched rigid-flexible impellers were investigated using a combined computational fluid dynamics (CFD) and population balance model (PBM) approach. A classical Eulerian-Eulerian approach coupled with standard k-e turbulence model was employed to simulate gas-liquid turbulent flow in the stirred tank. The multiple reference frame (MRF) approach was used to simulate impeller rotation. The effects of impeller type, flexible connection piece length, aperture size/ratio, impeller speed and superficial gas velocity on the local gas holdup and bubble size distribution for the gas-liquid dispersion process were investigated. Results showed that a long flexible connection piece length was conductive to the gas-liquid dispersion process. The optimum aperture ratio and aperture diameter were 12 % and 8 mm, respectively, for the gas-liquid dispersion process. Punched rigid-flexible impeller could reduce the differential pressure ahead and behind the impeller blade, decrease the size of low-pressure zone, and improve the water shear strain rate compared with rigid impeller and rigid-flexible impeller at the same Pg,v. It was found that punched rigid-flexible impeller was more efficient in terms of gas dispersibility than rigid impeller and rigid-flexible impeller.
Comparative evaluation of neuroendocrine dysfunction in children with craniopharyngiomas before and after mass effects are removed
Authors: Guo Ying , Wang Yonggang , Ni Ming , Zhang Yazhuo , Zhong Liyong 
Published: January 2019

Abstract

Objective
To compare the effects of mass effects in situ (MEIS) and after neurosurgery (ANS) on neuroendocrine function in children with craniopharyngioma.

Methods
We retrospectively investigated 185 cases of children with craniopharyngioma who underwent neurosurgical treatment at the Beijing Tiantan Hospital from 2011 to 2016. The neuroendocrine function of patients was compared before and after tumor removal.

Results
Compared with the MEIS, the incidence of growth hormone insulin-like growth factor 1 axis dysfunction (47.03% vs. 57.30%), pituitary-thyroid axis dysfunction (20.00% vs. 50.27%), pituitary-adrenal axis dysfunction (18.38% vs. 43.78%) and diabetes insipidus (26.49% vs. 44.86%) was significantly increased in the ANS status. The incidence of hyperprolactinemia significantly decreased from 28.11% in the MEIS status to 20.54% in the ANS status. Compared with the MEIS group, changes in appetite, development of diabetes insipidus, body temperature dysregulation, sleeping disorders, personality abnormalities and cognitive abnormalities were more frequent after ANS, yet no statistically significant differences were found.

Conclusions
Endocrine dysfunction is common in children with craniopharyngioma. Both MEIS and ANS can be harmful to neuroendocrine function, and neurosurgical treatment may increase the level of neuroendocrine dysfunction.
The Ideal Character of the General Will and Popular Sovereignty in Kant
Authors: Marey Macarena 
Published: January 2019

Abstract
In this paper, I examine Kant’s reception of and solution to the problem of the unity of the political will. I propose that Kant distances himself from the modern paradigmatic foundations of sovereignty principally with his theses of the ideality of the general will (section II) and of the apriority of the justification of popular sovereignty (section III). My interpretative hypothesis is that Kant solves the problem by grounding sovereignty in a conceptual element which is new in the history of political philosophy, i. e. the a priori unified omnilateral will. In section IV, I explain why my reading of the ideality of the general will can respond to seemingly plausible objections arising from Kant’s own texts and how it works in the face of concrete political states of affairs.
A Tale of Two Conflicts
Authors: Timmermann Jens 
Published: January 2019

Abstract
Pauline Kleingeld’s “Contradiction and Kant’s Formula of Universal Law”, published in this journal in 2017, presents a powerful challenge to what has become the standard (‘practical’) reconstruction of the categorical imperative. In this response to Kleingeld, I argue that she is right to emphasise the ‘simultaneity requirement’ - that we must be able to will a proposed maxim and ‘simulataneously’, ‘also’ or ‘at the same time’ the maxim in its universalised form - but I deny that this removes the categorical imperative test from the world of universalisation because the agent must be understood as part of that world. There are two distinct types of conflict: a contradiction that results from non-universalisability and Kleingeld’s ‘volitional’ conflict, located within the will of the immoral agent. The standard ‘practical’ reconstruction of the categorical imperative remains largely intact.
Crystal structure of methyl 2,7,7-trimethyl-4-(3-methylthiophen-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C19H23NO3S
Authors: Lu Xiao-Qing , Zhang Huan-Hu , Yang Rui , Zhu Si-Yuan , Wang Fu-Sheng 
Published: January 2019

Abstract
C19H23NO3S, monoclinic, P21/n (no. 14), a = 9.0403(15) Å, b = 18.213(3) Å, c = 11.1889(19) Å, β = 107.964(2)°, V = 1752.4(5) Å3, Z = 4, R
gt(F) = 0.0498, wR
ref(F
2) = 0.1536, T = 296(2) K.
Remembering Joseph Neparrŋa Gumbula
Authors: Marett Allan 
Published: January 2019

AbstractJoseph Neparrŋa Gumbula was both a senior Yolŋu ceremonial leader and performer—Dalkarramirri and Liya-ŋärra’mirri—and a visionary rock musician who was able to enact the Law in multiple media. This short article reflects upon Gumbula’s contribution to the National Recording Project for Indigenous Performance in Australia and other intercultural projects, and in particular the author’s experiences of performing wangga songs from the Daly region with Gumbula in a number of intercultural contexts.
Sun Setting over the Arafura Sea and Other Opportunities: Working with Joe Gumbula
Authors: Mant Julia 
Published: January 2019

AbstractArchives are full of emotional connections between records and researchers that can span surprise, delight, anger, indifference and engagement. In this short reflection, I share my stories of the archival and personal photographs that connected me and Joe Gumbula. It was not always easy for Joe to be a conduit between two cultures, to bring people and collections together over time and space, and to balance his fluency in Yolŋu knowledge against the archive’s unfamiliar institutional processes. Through our collaborations, I learned key lessons for professional archivists about building trust, connections, follow-through, presence and listening that support the active management of historical images.
The Yidaki: A Triumph of Mind over Matter in Tribute to Joe Gumbula
Authors: Hollenberg Lloyd C.L. 
Published: January 2019

AbstractAs a physicist, I have been privileged to intersect with the world of ethnomusicology through my research on the acoustics of the didjeridu, the highlight of which was to meet and work with Joe Neparrŋa Gumbula. This is a brief account of my perspective on that journey, the research undertaken, and the role that Joe played in it.
L’ambigüité structurale et l’acquisition des compétences linguistiques en français en passant par la langue maternelle
Authors: Nwosu Nnenna 
Published: January 2019

Résumé
Cet article présente l’analyse de textes produits par des étudiants du niveau universitaire apprenant le français au Nigeria. Les textes ont été recueillis dans une situation formelle. L’objectif a été d’évaluer les compétences à l’écrit en français (compétences pragmatique, linguistique, discursive) des étudiants à tous les niveaux du programme de Licence au département de Langues européennes à l’Université de Lagos.
Les étudiants ont été invités à rédiger un texte sur le sujet – « Narrez un évènement inoubliable que vous aurez vécu ». Les résultats de l’analyse montrent que leur LM-Igbo, facilite le transfert de compétence vers le français plutôt que leur langue de scolarisation – l’anglais.
An Enhanced Hybrid Feature Selection Approach for High Dimensional Data Processing
Authors: Lincy Blessy Trencia , Nagarajan Suresh Kumar 
Published: January 2019

Abstract
A huge volume of data is being generated day by day, each and every second, with mounting trends and technologies. Big data has evolved as an ultimate approach in data origination, attainment, and processing and also analysis, coping with the heterogeneity of the data in order to obtain useful insights from it. It is obvious that there is no point in having the data without quality. Hence, in order to use or leverage the data in a more apposite manner, data with quality are important. Numerous technologies are being developed with the evolution of big data. The input to those technologies and approaches is to be processed in such a way that they guarantee data quality, to yield better processing and results. An effective preprocessing approach is proposed in this article for the processing of big data. No single model can work well in the case of data processing, considering the challenges imposed with big data. Hence, a hybrid preprocessing approach is imposed here to deal with the data and processing, ensuring a better outcome. The results show that the approach enhances the quality of the data and is more effective. This approach, along with the big data platform using the Spark framework, increases the overall performance of the processing.