bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação dos Resultados da CONITEC no Novo Processo Administrativo de Inclusão, Exclusão e Alteração de Tecnologias de Saúde ao SUS
Authors: Macatrão Nogueira Nunes Luciana , Dourado Arrais Paulo Sérgio , Brito Passos Ana Cláudia , Lopes Campos Reis Henry Pablo , De Souza Ponciano Ângela Maria , De França Fonteles Marta Maria 
Published: March 2018

A partir de 2011 uma série de legislações e atos normativos foram editados trazendo profundas transformações na incorporação, exclusão e alteração de tecnologias em saúde ao SUS como, por exemplo, a criação da Comissão Nacional de Incorporação de Tecnologias (CONITEC). Entendendo que essas inovações institucionais e legislativas estabeleceram um novo quadro da ATS no Brasil, que demanda uma avaliação aprofundada quanto a seus efeitos, o presente trabalho analisou, de maneira descritiva, os resultados da CONITEC, nos processos administrativos de incorporação, exclusão e alteração de tecnologias de saúde ao SUS, de janeiro de 2012 à julho de 2015. A coleta de dados ocorreu por análise documental, mediante pesquisa em fontes secundárias, mais especificamente nos bancos de dados disponibilizados para consulta nas páginas eletrônicas do Ministério da Saúde. Constatou-se que o Poder Público foi o principal demandante, responsável por 58,1% dos 420 processos. O motivo de solicitação mais recorrente foi a incorporação (93,8%) e o tipo de tecnologia (medicamento; 61,4%). Dos medicamentos incorporados, prevaleceram as classes dos antineoplásicos/imunomoduladores (39,47%). Na avaliação dos motivos de indeferimento de pedidos de incorporação de medicamentos na CONITEC, as principais razões para o resultado negativo das demandas foi o fato dos estudos referentes ao medicamento em questão terem apresentado resultados limitados de eficácia e/ou segurança, ou não terem estabelecido os benefícios clínicos. Dos 420 processos submetidos à CONITEC, 85,5% foram classificados como concluídos e 14,5% ainda se encontravam em algum estágio do processo de análise pela CONITEC. Por sua vez, dos 359 já concluídos, houve decisão pela incorporação da tecnologia em 137 (38,2%) deles, pela não incorporação em 72 (20,1%) e, pela exclusão da tecnologia da Relação Nacional de Ações e Serviços de Saúde (RENASES) e Relação Nacional de Medicamentos Essenciais (RENAME), em 18 casos (5,0%). Os dados indicaram um total de 120 consultas públicas das quais 116 receberam contribuições públicas demonstrando, assim, o interesse da população em participar dos processos da CONITEC, bem como a relevância dessa inovação no procedimento. Foram destacados os avanços decorrentes dessas inovações no processo, bem como identificados desafios para os gestores e a comunidade acadêmica, uma vez que esse novo processo administrativo precisa ser constantemente monitorado, com levantamento, tratamento e categorização dos dados das demandas submetidas à CONITEC, a fim de comparar os resultados empíricos do processo com as expectativas e planos dos gestores, anseios dos usuários dos serviços e com os estudos de cunho programático na área de ATS.
Rasgos acústicos de las obstruyentes simples y eyectivas en el maya yucateco del Camino Real: bases para una caracterización dialectal.
Authors: González Poot Antonio A. 
Published: March 2018

El presente análisis de las obstruyentes eyectivas y simples del maya yucateco en contextos pre y postvocálicos contribuye a la necesidad de contar con trabajos que identifiquen acústicamente a los miembros no pulmonares de este contraste. Los resultados de nuestro estudio sugieren la existencia de pistas acústicas bien definidas para los sonidos en cuestión. Las oclusivas simples y eyectivas prevocálicas del maya yucateco pueden distinguirse mínimamente por la duración del voice onset time (VOT) y la intensidad de la explosión; el mismo contraste en posición postvocálica se identifica por diferencias en la duración del periodo de silencio entre el cierre de la vocal y la explosión de la oclusiva, así como por la intensidad misma de esta explosión. Por su parte, las africadas simples y eyectivas prevocálicas contrastan acústicamente tanto por la duración e intensidad del ruido, como por el VOT y la presencia/ausencia de silencio previo a la liberación de la oclusión glotal. Finalmente, el contraste simple/eyectiva en africadas postvocálicas está dado por diferencias en la duración del silencio tras el cierre vocálico, así como por la intensidad y la duración de la fricción. Original recibido: 2016/10/16Dictamen enviado al autor: 2017/04/15Aceptado: 2017/11/09
Studi Perbedaan Niat Beli Green Electricity Product Berdasarkan Gender
Authors: Indarwati Tias Andarini , Untarini Nindria 
Published: March 2018

Consumers adapt to this situation by considering environmental issue when shopping and by their purchase behavior. The aims of this paper are examines of differences of environment awareness and purchase intentions between male and female of students of Surabaya State University. Secondly, examines also role linearly of environment awareness on purchase intentions. Examines role linearly of environment awareness on purchase intentions of green electricity product using simple linier regression analysis. The results indicate that there are no differences of environment awareness and purchase intentions at the students of Surabaya State University by gender. And finally, environmental awareness has also positive effect on purchase intentions. The results of this study have implications for marketers in identifying, designing, and managing marketing mix with consider discrepancy of purchase intentions in the green electricity product by gender.
Pengaruh Control Test Terhadap Ketepatan Tingkat Pengambilan Keputusan Akuntan Publik Dalam Menyatakan Opini di Kantor Akuntan Publik Surakarta dan Jogjakarta
Authors: . Mulyadi 
Published: March 2018

The purpose of this study was to see how the influence of Structure of Internal Control which includes authorization of transactions and activities were adequate, the separation of functions and duties, the design and use of documents and records adequate, secure assets and adequate records, as well as the examination independent of the performance of the level the accuracy of decision-making Public Accountant in determining the audit opinion. Analysis techniques used in this research is the analysis of data validity, realiabilitas and hypothesis testing that includes testing multiple linear regression analysis, t-test, f and determination test. T test results is a positive effect and does not significantly. Authorization transaction F-test, is a positive effect and significanlty. Test results showed that the variables R2 Authorization transaction, Separation of Duties and activities were adequate, the use of documents and records adequate, Sentry asset and independent checks on performance are able to explain 12.9% of the variable precision of giving opinions by public accountants, while the rest of 87 , 1% is influenced by other variables.
Diagnostic problems with follicular thyroid cancer – case study
Authors: Koziolek Monika , Sieradzka Anna , Jakuszewski Michal , Osowicz-Korolonek Lilianna , Karpinska-Kaczmarczyk Katarzyna , Syrenicz Anhelli 
Published: March 2018

Abstract
The diagnosis of follicular thyroid cancer is based on postoperative histopathology assessment. In its minimally invasive form, the signs of vascular invasion and capsular infiltration may sometimes be seen only in a small tumor fragment; hence, the diagnosis should be based on multiple histopathology specimens. This case study is a report on a 70-year-old female who was diagnosed with spinal metastasis of follicular thyroid cancer. This diagnosis was established 5 years after partial strumectomy due to goiter and there were no signs of thyroid cancer in postoperative histopathology assessment. Based on this case and literature reports, the authors conclude that the diagnosis of follicular thyroid cancer, especially its minimally invasive forms, may pose a diagnostic problem even when based on postoperative histopathology.
Sources of patients’ knowledge on the treatment of missing teeth with implants
Authors: Szymanska Jolanta , Koszuta Agnieszka , Drop Katarzyna 
Published: March 2018

Abstract
The number of patients who take the decision to have implantoprosthetic treatment keeps increasing. The aim of this study was to determine the sources of knowledge about possibilities of treating missing teeth with implants. The survey was conducted among 464 patients of both sexes aged from 20 to 74 years, treated with dental implants at the Non-Public Healthcare Centre “Dental” in Tomaszów Mazowiecki. The patients answered questions in an anonymous questionnaire. The questions included age, place of residence and source of knowledge about implants. Persons aged up to 40 years frequently obtained knowledge about the possibility of using implants from the media; patients aged 40-60 years - from their dentist, and people over 60 years of age - from family or friends. Persons living in rural areas or small town frequently acquired knowledge of the possibility of dental implants from the dentist, the city residents - from family or friends. The results of the survey indicate that the dentist is most commonly the main source of information about the possibility of replacing the missing teeth with implants, less family and friends and the media. The source of acquiring knowledge in this field varies depending on the age and place of residence of the persons concerned.
Plasma levels of catecholamines and asymmetric dimethylarginine levels as predictive values of mortality among hemodialysis patients
Authors: Dziedzic Marcin , Orlowska Ewelina , Gawel Kinga , Zawadzka Magdalena , Bednarek-Skublewska Anna , Solski Janusz 
Published: March 2018

Abstract
The aim of the study was to assess plasma concentration of catecholamines and asymmetric dimethyl arginine levels and a possible relationship to predict the mortality rates among hemodialysis patients. The study population comprised 27 subjects, aged 65-70 years. Each patient underwent dialysis thrice a week. Furthermore, the median duration of hemodialysis was 3.5 years. Based on the conducted research, it can be concluded that the concentrations of adrenaline and the level of asymmetric dimethylarginine have predictive value of mortality among hemodialysis patients. Of note, lowering plasma asymmetric dimethylarginine concentration may represent therapeutic target for prevention of progressive renal damage.
In vitro evaluation of immunogenic properties of active dressings
Authors: Orlowska Joanna , Kurczewska Urszula , Derwinska Katarzyna , Orlowski Wojciech , Orszulak-Michalak Daria 
Published: March 2018

Abstract
The aim of this study was in vitro evaluation of the level of the immune response in relation to wound dressings composed of alginate, calcium carboxymethylcellulose, and dibutyrylochitin and determination of the direction of response, which will make referring next to the results of in vivo phase possible.
The subject of the experiments was to examine the commercially available, biodegradable alginate dressing, commercially available but not biodegradable dressing constructed from the sodium carboxymethylcellulose, and synthesized in house biodegradable dressing constructed of the dibutyrylchitin. To determine the direction of the immune response, the degree of secretion of pro-inflammatory interleukin (IL-1, IL-6) and antiinflammatory (IL-10) interleukin from murine fibroblasts having contact with the tested dressings (ELISA enzyme linked immunosorbent assay), was tested.
Immunomodulatory and anti-inflammatory properties of macrolides
Authors: Bulska Magdalena , Orszulak-Michalak Daria 
Published: March 2018

Abstract
Macrolides are a group of antibiotics whose activity is ascribable to the presence of the macrolide ring, to which one or more deoxy sugars may be attached. Two properties are inherent in this group of antibiotics, the immunomodulatory and the anti-inflammatory actions, ensuring great efficacy in a wide spectrum of infections. Macrolides demonstrate several immunomodulatory activities both in vitro and in vivo. They can down-regulate prolonged inflammation, increase mucus clearance, prevent the formation of bacterial biofilm and either enhance or reduce activation of the immune system. According to given properties and exceptional effects on bacterial phatogens, the macrolide antimicrobial agents have been found to serve a unique role in the management of chronic airway disorders, including diffuse panbronchiolitis, cystic fibrosis and chronic obstructive pulmonary disease. Use of macrolides can result in clinical improvement in patients with severe, chronic inflammatory airway diseases, improving their spirometry indicators, gas exchange and overall quality of life.
Determination of caffeic acid in root and rhizome of Black cohosh (Cimicifuga racemosa (L.) Nutt.)
Authors: Zapala Karolina , Szymczak Grazyna , Wojciak-Kosior Magdalena 
Published: March 2018

Abstract
Cimicifuga racemosa, is a plant with a diverse and long history of medicinal use. Caffeic acid, bioactive compound, which often occurs with other polyphenols can influence the biological activity of this plant. The aim of our work was quantitative analysis of caffeic acid in roots and rhizomes of two varieties of C. racemosa. Analysis was performed by HPLC method. The extracts were separated on C18 reversed-phase column using mixture of methanol, water and formic acid (25:75:0.5 v/v/v) as a mobile phase. The flow rate of eluent was 1.0 ml·min-1. The obtained validation parameters such as linearity, linear regression equation and precision expressed as a relative standard deviation were adequate for quantitative determination. Caffeic acid was found in all tested extracts. The highest total amount of caffeic acid was determined in C. racemosa var. racemosa (255.3 μg·g-1) while its concentration in C. racemosa var. cordifolia was significantly lower (213.0 μg·g-1).
Darlington CMOS İnverter Tabanlı Paralel Analog-Sayısal Dönüştürücü Tasarımı
Authors: Aytar Oktay 
Published: March 2018

Yapılan
bu çalışmada, CMOS eşik gerilimine göre çalışan darlington cmos inverter devresi
ile paralel analog-sayısal dönüştürücü(A/D) yapısı tasarlanmıştır. Böylece bu yapıda nicemleme gerilimlerini elde
etmek için kullanılan direnç bölme dizisine ihtiyaç kalmamıştır. Darlington
yapısı, genellikle bipolar transistor için kullanılan bir yapı iken burada cmos
yapısı için önerilmiştir. Bu sayede kullanılan inverter devresinin kazancı
artırılmıştır. Önerilen 4-bit paralel
A/S dönüştürücü için besleme gerilimi +1.8V, sistemin saat frekansı 10GHz, analog giriş
işaretinin frekansı 100MHz alındığında elde edilen simülasyon sonuçlarına göre
güç tüketimi 96.6mW, INL hatası (0/-1.24)LSB, DNL hatası ise (-0.71/+0.82)LSB
olarak ölçülmüştür. Bütün simülasyon sonuçları şematik devre üzerinden
alınmıştır.
INCLUSÃO E FORMAÇÃO DE PROFESSORES NO CONTEXTO EDUCACIONAL PÚBLICO BRASILEIRO
Authors: Alves de Souza Maria Izania , Ferreira Lúcio Fernandes 
Published: March 2018

Atualmente, muito se discute sobre inclusão. O debate por mais que seja recorrente é inesgotável, pois inúmeras situações, positivas e/ou negativas, emergem diariamente no âmbito escolar envolvendo todos os seus atores. Este artigo de revisão de literatura pretende descrever os principais momentos em que a inclusão tornou- se pauta nacional e mundial, contextualizando a história das transformações sociais e políticas em prol da pessoa com deficiência, seus paradigmas e a formação do professor frente a esse desafio. A pesquisa é de caráter bibliográfico com abordagem qualitativa, por meio dela foi possível perceber as dificuldades existentes no processo de implantação da educação especial e posteriormente do processo de inclusão no cenário nacional. Este trabalho propicia uma reflexão, acerca dos paradigmas da educação especial e da inclusão no cenário nacional, observando as transformações sociais, econômicas e políticas que incidem diretamente em todo o processo de educação em nosso país.
Palavras-chave: Inclusão; educação inclusiva; formação docente.
APRESENTAÇÃO: DA EDUCAÇÃO QUE PENSA, AGE E ENFRENTA
Authors: Maia Garcia Fabiane , Ferreira David Goes 
Published: March 2018

O terceiro número on-line da Revista Amazônida apresenta pesquisas que tratam temas variados da educação básica, que vão da organização do trabalho docente a experiências educativas no espaço escolar em diferentes espaços e geografias. As análises são parte de um contexto de “reformas” e mudanças que se apresentam como parte da política oficial e legal para o campo da educação. Esses processos chegam à sociedade como necessários para uma “modernização” das áreas de relevância social, e dentre elas, a educação. Um dos exemplos mais simbólicos é a propalada Reforma do Ensino Médio, que aos olhos críticos e proeminentes em educação, se configura como um regresso aos moldes de um Ensino Médio dual, atrelado à modernização tecnológica, a demanda mercadológica e a lógica produtivista. Assim, neste volume os resultados das pesquisas perpassam a organização do trabalho docente como instrumento de efetivação do direito à educação e a formação docente para atendimento à educação inclusiva, discussões que se atrelam ao campo do financiamento, da transferência de recursos públicos para o setor privado e ao da gestão de resultados, em que nem os jovens e as crianças são poupados. A configuração disposta resulta da seleção de oito artigos, com temáticas diversificadas, e que procuram apresentar o pensamento e as preocupações acadêmicas em vigor. Assim, este número conta com colaborações de pesquisadores de distintas instituições como, por exemplo, a Universidade Estadual de Campinas (UNICAMP), a Universidade Federal do Ceará (UFC), a Universidade Federal de Rondônia (UNIR), a Universidade Federal do Amazonas (UFAM), a Universidade do Estado do Amazonas (UEA), a Secretaria de Educação do Amazonas (SEDUC/AM) e a Universidade Nilton Lins (UNINILTONLINS). Os envolvidos asseguram a esta edição uma publicação uma interlocução com distintos pesquisadores, tanto no aspecto institucional quanto geográfico.
The effects of ozonated, chlorinated, celestite stone-treated, natural spring and pine resin-treated waters on performance, oxidative stress and carcass parameters in Japanese quail
Authors: Seren Burak , Nursoy Hüseyin 
Published: March 2018

This study was conducted to assess the effects of 5 types of water: Ozonated, Chlorinated, Celestite Stone-treated, Natural Spring Waters and Pin Resin-treated water on performance, oxidative stress and carcass parameters in Japanese quail. A total of 150, 3-day old mixed female-male quails were used into 5 groups of 30 birds for each water group; each group was divided into 3 replicate subgroups of 10 birds. The experiment was continued for 7 weeks and quail were fed one experimental diet, and the different water sources were given ad libitum during in the trial. Statistical differences among water sources were observed on pH and Electrical Conductivity and content of Ca, Mg, Cl and Total Bacteria. Live weight, daily live weight gain, water and feed intake were the highest in the drinkers of Natural Spring Water, while the lowest for drinkers of Resin-treated Water (p&lt;0.001). The lowest level of serum malondialdehyde of was observed in drinkers of Natural Spring Water (1.54 µM/L), and the highest malondialdehyde level in drinkers of Resin-treated Water (4.27 µM/L; P&lt;0.001). The sources of water of trial were determined to have no effects on slaughter weight, carcass weight and carcass yield (p&gt;0.05). As a result, the amount of total dissolved solids of water were the positive effect on live weight, feed consumption, water intake, feed conversion ratio and oxidative stress biomarkers.
Pathological effects of Helleborus Orientalis used in Turkish traditional medicine, in rats
Authors: ŞENNAZLI Gülbin , MATUR Erdal 
Published: March 2018

elleborus orientalis Lam., a member of the family Ranunculaceae, is one of the medical plants, which is naturally grown in Turkey flora. Roots of Helleborus orientalis are used for the treatment of farm animals by implanting subcutaneously in the public. This study was planned to investigate the histopathological changes in liver, heart and skin of rats that were applied plant raw material (PRM), water extract (WE) and methanol extracts (ME) of Helleborus orientalis subcutaneously. Foci of abscess were determined in the subcutaneous tissue of all 3 experimental groups at the end of 10-day experimental period. During the histopathological examination of the liver, parenchymatous degenerations were observed in the hepatocytes of PRM and WE group rats, and caseous necrosis were determined in the liver of all rats in ME group. Hyaline degenerations were observed in myocard cells of the rats in PRM and WE groups. Furthermore hyaline degenerations and edema occurred locally in the myocard of all animals in ME group. Vacuolar zones were found in certain myocard cells. The results of the present study indicate that long-term use of Helleborus orientalis might be harmful due to its pathological effects on some tissue.
SECURITY IN SUSTAINABLE DEVELOPMENT: COMPARING UNITED NATIONS 2030 AGENDA FOR SUSTAINABLE DEVELOPMENT WITH MILLENNIUM DECLARATION
Authors: BARBAK Ahmet 
Published: March 2018

This study aims to compare United Nations 2030 Agenda for Sustainable Development with Millennium Declaration in terms of their security conceptualizations to explore changes in security thinking and policy components (goals, targets, principles, priorities etc.) over time. In doing so, it is envisaged that United Nations’ expectations from member states regarding their national security policies and organizations could be revealed. Security thinking has changed since late 1980’s with the introduction of sustainable development approach by the United Nations. This shift in security thinking encompasses human security and security-development nexus. Holding all member states responsible, Millennium Declaration and 2030 Agenda for Sustainable Development constitute the primary and the most recent outcome documents of United Nations’ sustainable development policy. Both documents have security components. This enables extracting security elements and comparing them with an analytical manner. Consequently, findings are compared and discussed in terms of public policy and organization at national level.
EKONOMİK KALKINMA SÜRECİNDE İKTİSADİ BİRLEŞMELERİN ROLÜ: BİR ALAN ARAŞTIRMASI
Authors: TUNÇ Hakan 
Published: March 2018

Ülkelerin
kendi aralarındaki iktisadi faaliyetleri, daha avantajlı gerçekleştirebilmek
için bağlayıcı bir sözleşme aracılığıyla gerçekleştirmelerine iktisadi birleşme
denmektedir. Bu çalışma da iktisadi birleşmelerin önemli aşamalarından biri olan
Gümrük Birliği’nin Türkiye’nin kalkınma sürecine katkısının incelenmesi
amaçlanmıştır. Çalışmanın birinci kısmında 28 üyeli Avrupa birliği ülkeleri ile
yapılan ihracat ve ithalat rakamları fasıllara göre sıralanarak, kalkınmaya
ilişkin olası etkileri tartışılmıştır.

Ayrıca Türkiye’de 1999-2016 yılları arasında
gerçekleşen ekonomik büyüme ile aynı dönemde gerçekleşen ihracattaki,
ithalattaki ve dış ticaret hacmindeki
büyüme arasında Sperman Korelasyon yardımıyla 0.95 güven aralığında
pozitif yönlü güçlü ilişki olduğunu saptanmıştır. Çalışmanın son kısmında
Türkiye’nin Gümrük Birliği’ne girmesinin, Türkiye’nin Kalkınma sürecine etkisi
konusunda kişilerin düşüncelerini almak amacıyla likert ölçekte bir anket
uygulaması yapılmış olup genel
itibariyle bu ilişkiye olumlu baktıklarını ve kişilerin medeni durumu yaş
aralığı ve mesleği ile Türkiye’nin Gümrük Birliğine girmesinin ülke vatandaşlarının
gelirlerini arttırdığını ve refah seviyesini yükselttiğini düşüncesi arasında
istatistiksel olarak anlamlı bir farlılık saptanmıştır.