bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast cancer‐specific survival by age: Worse outcomes for the oldest patients
Authors: Freedman Rachel A. , Keating Nancy L. , Lin Nancy U. , Winer Eric P. , Vaz‐Luis Ines , Lii Joyce , Exman Pedro , Barry William T. 
Published: March 2018

BACKGROUNDAlthough breast cancer often is perceived to be indolent in older women, breast cancer outcomes in the oldest patients are variable. In the current study, the authors examined breast cancer‐specific death by age, stage, and disease subtype in a large, population‐based cohort.METHODSUsing Surveillance, Epidemiology, and End Results data, a total of 486,118 women diagnosed with American Joint Committee on Cancer stage I to IV breast cancer between 2000 and 2012 were identified. Using a series of Fine and Gray regression models to account for competing risk, the authors examined the risk of breast cancer‐specific death by age and stage (I‐IV) for subcohorts with hormone receptor (HR)‐positive, HR‐negative, human epidermal growth factor receptor 2‐positive, and triple‐negative disease, adjusting for demographic and clinical variables.RESULTSOverall, 18% of women were aged 65 to 74 years, 13% were aged 75 to 84 years, and 4% were aged ≥85 years. Regardless of stage of disease within the HR‐positive and HR‐negative cohorts, patients aged ≥75 years (vs those aged 55‐64 years) experienced a higher adjusted hazard of breast cancer‐specific death, which was particularly evident for those with early‐stage, HR‐positive disease (hazard ratio for those aged 75‐84 years, 1.88 [95% confidence interval, 1.68‐2.09] and hazard ratio for those aged ≥85 years, 3.59 [95% confidence interval, 3.12‐4.13] [both for stage I disease]). In the cohorts with human epidermal growth factor receptor 2‐positive and triple‐negative disease, women aged ≥70 years had a consistently higher risk of breast cancer‐specific death across disease stages (vs those aged 51‐60 years), with the exception of stage IV triple‐negative disease.CONCLUSIONSOlder patients experience worse breast cancer outcomes, regardless of disease subtype and stage. With an increasing number of older patients anticipated to develop breast cancer in the future, addressing disparities for older patients must emerge as a clinical and research priority. Cancer 2018;124:2184‐91. © 2018 American Cancer Society.
Ratiometric Piezochromism of Electrospun Polymer Films: Intermolecular Interactions for Enhanced Sensitivity and Color Difference
Authors: Yang Heyi , Sun Zhanghua , Lv Chunyan , Qile Moge , Wang Kai , Gao Huiwen , Zou Bo , Song Qingbao , Zhang Yujian 
Published: March 2018

AbstractMany piezochromic luminescent (PCL) dyes are known for their fluorescent switching capacity in the powdered phase, but they are usually difficult to utilize practically owing to poor mechanical properties. Herein, a nanofiber film fabricated through an electrospinning process is doped with PCL dye. The electrospun film not only reveals the mechanics of macromolecular materials, but also achieves precise, gradient pressure recognition (ratiometric PCL behavior). The PCL sensitivity and color difference of the dye in a crystalline state are calculated to be 15.7 nm GPa−1 and 149 nm, respectively. The sensitivity of an electrospun film containing 0.1 % (w/w) dye decreased to 3.6 nm GPa−1. Moreover, the individual effects of molecular conformation and intermolecular interaction on the PCL properties have been clearly distinguished through in situ high‐pressure experiments. Intermolecular interactions play a more significant role in PCL color difference and sensitivity. The film fabricated through an electrospinning process contributes to understanding of the working mechanism and real applications of piezochromic materials.
Enhancing the Lithium Storage Performance of Graphene/SnO2 Nanorods by a Carbon‐Riveting Strategy
Authors: Liu Xianghong , Ma Tiantian , Sun Li , Xu Yongshan , Zhang Jun , Pinna Nicola 
Published: March 2018

AbstractGraphene/metal oxide (MO) nanocomposites hold great promise for application as anodes in lithium‐ion batteries (LIBs). However, the restacking of graphene during subsequent processing remains a challenge to overcome for enhanced lithium storage properties. Herein, the fabrication of sandwich‐architecture carbon‐riveted graphene/SnO2 nanorods, in which the SnO2 nanorods are confined in the nanospaces formed by the carbon layers on graphene, by a two‐step hydrothermal process followed by thermal treatment, is reported. Electrochemical tests show that the carbon‐riveted nanolayers significantly improve the lithium storage performance of graphene/SnO2. The nanocomposite displays a high reversible capacity of 815 mAh g−1 after 150 cycles at 100 mA g−1 and high cycling stability at 1000 mA g−1. This work provides an efficient way to manipulate graphene/MO‐based nanocomposites for LIBs with improved performance.
Low‐Cost K4Fe(CN)6 as a High‐Voltage Cathode for Potassium‐Ion Batteries
Authors: Pei Yuhou , Mu Chaonan , Li Haixia , Li Fujun , Chen Jun 
Published: March 2018

AbstractPotassium‐ion batteries (KIBs) are of interest for large‐scale electrical energy storage, owing to the abundance of K resources and potential high energy density. Low‐cost cathodes with high performance are crucial for KIBs. Herein, K4Fe(CN)6 is shown to be a low‐cost and high‐voltage cathode for KIBs. It can deliver a high voltage of approximately 3.6 V and a discharge capacity of 65.5 mAh g−1 with a lifespan of 400 cycles of discharge and charge. This is attributed to the strong σ bonds between C atoms and Fe and to the reduced particle size and good contact with conductive carbon brought about by ball milling, which benefit both the K+ ion and the electronic conduction. The [Fe(CN)6]3−/4− redox couple is found to be responsible for charge compensation upon reversible extraction/insertion of K+ from/into K4Fe(CN)6. The high voltage and stability of K4Fe(CN)6 will make it a promising low‐cost cathode for KIBs and encourage more investigations into high‐performance cathode materials.
Antibody‐based cell‐surface proteome profiling of metastatic breast cancer primary explants and cell lines
Authors: Donnenberg Vera S. , Zhang Jayce Jieming , Moravcikova Erika , Meyer Ernest Michael , Lu Haihui , Carson Christian T. , Donnenberg Albert D. 
Published: March 2018

AbstractFlow cytometric cell surface proteomics provides a new and powerful tool to determine changes accompanying neoplastic transformation and invasion, providing clues to essential interactions with the microenvironment as well as leads for potential therapeutic targets. One of the most important advantages of flow cytometric cell surface proteomics is that it can be performed on living cells that can be sorted for further characterization and functional studies. Here, we document the surface proteome of clonogenic metastatic breast cancer (MBrCa) explants, which was strikingly similar to that of normal mesenchymal stromal cells (P = 0.017, associated with Pearson correlation coefficient) and transformed mammary epithelial cells (P = 0.022). Markers specifically upregulated on MBrCa included CD200 (Ox2), CD51/CD61 (Integrin α5/β3), CD26 (dipeptidyl peptidase‐4), CD165 (c‐Cbl), and CD54 (ICAM‐1). Proteins progressively upregulated in a model of neoplastic transformation and invasion included CD26, CD63 (LAMP3), CD105 (Endoglin), CD107a (LAMP1), CD108 (Semaphorin 7A), CD109 (Integrin β4), CD151 (Raph blood group), and disialoganglioside G2. The proteome of the commonly used cell lines MDA‐MB‐231, MCF7, and BT‐474 were uncorrelated with that of MBrCa (P = 1.0, 1.0, 0.9, respectively). The comparison has demonstrated the mesenchymal nature of clonogenic cells isolated by short‐term culture of metastatic breast cancer, provided several leads for biomarkers and potential targets for anti‐invasive therapy, including CD200, and highlighted the limitations of breast cancer cell lines for representing the cell surface biology of breast cancer. © 2017 International Society for Advancement of Cytometry
An extended ECC‐based anonymity‐preserving 3‐factor remote authentication scheme usable in TMIS
Authors: Chandrakar Preeti , Om Hari 
Published: March 2018

SummaryA telecare medicine information system (TMIS) helps in providing an efficient communication platform to patients from home to consult doctors at a clinical center. In TMIS, the patient's confidentiality, security, and mutual authentication are very crucial; so remote authentication plays a vital role for verifying the legitimacy of patients. Recently, Amin and Biswas have devised a remote authentication protocol for TMIS, claiming it to be secured from various malicious vulnerabilities. We examine this protocol and find that it is not able to withstand many attacks that include off‐line and online password‐guessing, identity‐guessing, user impersonation, privileged insider, and known session key temporary information attacks. We propose a 3‐factor–based authentication protocol for TMIS by overcoming these security shortcomings. We present its security verification in formal and informal ways, which assert its resistivity against various security threats. We use the Burrows‐Abadi‐Needham logic for validating it, and with the Automated Validation of Internet Security Protocols and Applications tool, it is simulated. Further, the performance evaluation and the security functionalities justify high degree of security with efficient complexity.
Non‐dominated sorting particle swarm optimization (NSPSO) and network security policy enforcement for Policy Space Analysis
Authors: Sureshkumar Thathan , Lingaraj Mani , Anand Bojan , Premkumar Thathan 
Published: March 2018

SummaryNetwork operators depend on security services with the aim of safeguarding their IT infrastructure. Various types of network security policies are employed on a global scale and are disseminated among several security middleboxes implemented in networks. But, owing to the complications in security policies, it is not quite efficient to directly use the path‐wise enforcement schemes that are prevalent. The major motivation of this work is to improve security levels and solve the policy enforcement problem. For the first time, this work reports the issue of policy enforcement on middleboxes. The major contribution of this work is to design security policy enforcement as a Weighted K Set Covering Problem, and we designed a Policy Space Analysis (PSA) tool intended for a group of operations in the security policy. This PSA tool was developed based on range‐signified hyper‐rectangles, which are indexed by the Hilbert R‐tree. Leveraging the PSA, we first investigated the topological features of various kinds of policies. Balancing the PSA tool in a non‐dominated sorting particle swarm optimization technique exposes the intrinsic difficulties of this security strategy and provides guidance for designing the enforcement approach. In addition, in this research, a new fuzzy rule‐based classification system is introduced for packet classification. A scope‐wise policy enforcement algorithm was proposed, which chooses a moderate number of enforcement network nodes for deploying multiple policy subsets in a greedy manner. This scheme is much quicker compared with the first one and therefore has found its application in real‐time deployments.
Are zooplankton communities structured by taxa ecological niches or by hydrological features?
Authors: Le Coz M. , Chambord S. , Souissi S. , Meire P. , Ovaert J. , Buffan‐Dubau E. , Prygiel J. , Azémar F. , Sossou A.C. , Lamothe S. , Julien F. , Ouddane B. , Net S. , Dumoulin D. , Tackx M. 
Published: March 2018

AbstractThis study aimed to clarify the mechanisms that structure zooplankton communities in a lowland river network. Fourteen stations on the Scheldt upper river basin (France/Belgium) were sampled during 4 campaigns in 2014–2015.Firstly, a niche analysis of zooplankton taxa was conducted for April and September 2014 using the outlying mean index (OMI) ordination technique. Then, application of Hutchinson's niche and of Hubbell's neutral theories to zooplankton community of the river network was tested for April and June 2015. We subsequently tested whether the taxa ecological preferences revealed were reflected in the April and June 2015 zooplankton spatial distributions.In April 2015, zooplankton community dissimilarity (Bray–Curtis distance) was more influenced by environmental conditions than by hydrological distance, in accordance with niche theory. In June 2015, a stronger influence of neutral processes was suggested by an important role of hydrology. In 2014 samples, 17 over 32 taxa presented significant marginality relying on the considered environmental parameters. This specialization was reflected in the 2015 community patterns, particularly in April. During this month, local environmental parameters were more influencing than hydrology, probably related to a higher environmental heterogeneity than in June 2015.Although zooplankters are often considered to be generalists and opportunists, mainly dependent of river hydrology, these results showed that even for passive dispersers in highly connected systems, niche processes contribute to community structuring by local filtering. Determination of species niche parameters is thus important to understand observed community patterns but also changes in species distribution relative to environmental and hydrological changes.
Social identity–aware opportunistic routing in mobile social networks
Authors: Wang Ranyin , Wang Xiaoming , Hao Fei , Zhang Lichen , Liu Sen , Wang Liang , Lin Yaguang 
Published: March 2018

AbstractMobile social networks, as a type of delay‐tolerant networks, are composed of nodes with different social properties in which information can be shared among them through opportunistic links. In such networks, it is important to analyze social properties of mobile nodes for transmitting information because they lack a stable source‐to‐destination delivery path and connect intermittently. Many social‐aware routing algorithms have been proposed to address these problems. However, these algorithms fail to achieve an optimal performance since they ignored an important social property, social identity. In this paper, we propose a social identity–aware opportunistic routing algorithm by considering social identities and social influences of mobile nodes in mobile social networks. It is shown that the social identity–aware opportunistic routing algorithm substantially improves the routing performance compared with the existing algorithms according to the simulation results in 2 real‐world human contact traces.
Emotional distress with dementia: A systematic review using corpus‐based analysis and meta‐ethnography
Authors: Petty Stephanie , Harvey Kevin , Griffiths Amanda , Coleston Donna Maria , Dening Tom 
Published: March 2018

ObjectiveMore understanding is needed about the emotional experiences of dementia from the perspective of the individual. This understanding can then inform the provision of health care to meet individual needs. This systematic review aimed to present all available descriptions of emotional distress and explanations for emotional distress experienced by individuals with dementia, articulated personally and by others.MethodsA systematic mixed‐method review identified literature that was screened and quality appraised. Data were analysed quantitatively and qualitatively using corpus‐based methods and meta‐ethnography.ResultsThe 121 included studies showed that individuals with dementia have expressed emotional distress comprehensibly. Family, professional caregivers, clinicians, and academic writers have also observed and described extreme emotional experiences. Feeling fearful and lonely were predominant and show the importance of anxiety in dementia. Explanations for emotional distress included threats to universal, human needs for identity, belonging, hope, and predictability.ConclusionsThe variable and personal emotional experiences of individuals with dementia are well described and should not continue to be overlooked. Limitations, future research, and clinical implications are discussed.
Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample
Authors: Espinoza Flor A. , Vergara Victor M. , Reyes Daisy , Anderson Nathaniel E. , Harenski Carla L. , Decety Jean , Rachakonda Srinivas , Damaraju Eswar , Rashid Barnaly , Miller Robyn L. , Koenigs Michael , Kosson David S. , Harenski Keith , Kiehl Kent A. , Calhoun Vince D. 
Published: March 2018

AbstractPsychopathy is a personality disorder characterized by antisocial behavior, lack of remorse and empathy, and impaired decision making. The disproportionate amount of crime committed by psychopaths has severe emotional and economic impacts on society. Here we examine the neural correlates associated with psychopathy to improve early assessment and perhaps inform treatments for this condition. Previous resting‐state functional magnetic resonance imaging (fMRI) studies in psychopathy have primarily focused on regions of interest. This study examines whole‐brain functional connectivity and its association to psychopathic traits. Psychopathy was hypothesized to be characterized by aberrant functional network connectivity (FNC) in several limbic/paralimbic networks. Group‐independent component and regression analyses were applied to a data set of resting‐state fMRI from 985 incarcerated adult males. We identified resting‐state networks (RSNs), estimated FNC between RSNs, and tested their association to psychopathy factors and total summary scores (Factor 1, interpersonal/affective; Factor 2, lifestyle/antisocial). Factor 1 scores showed both increased and reduced functional connectivity between RSNs from seven brain domains (sensorimotor, cerebellar, visual, salience, default mode, executive control, and attentional). Consistent with hypotheses, RSNs from the paralimbic system—insula, anterior and posterior cingulate cortex, amygdala, orbital frontal cortex, and superior temporal gyrus—were related to Factor 1 scores. No significant FNC associations were found with Factor 2 and total PCL‐R scores. In summary, results suggest that the affective and interpersonal symptoms of psychopathy (Factor 1) are associated with aberrant connectivity in multiple brain networks, including paralimbic regions.
Alcohol and injury risk at a Western Australian school Leavers Festival
Authors: Enkel Stephanie , Nimmo Lauren , Jancey Jonine , Leavy Justine 
Published: March 2018

AbstractBackgroundLeavers Festivals have become an institution for Australian youth to celebrate the completion of secondary school. Reported hazardous consumption of alcohol by leavers has focused concern on risk‐taking behaviour. In response to this, campaigns such as “Don't Drink and Drown” have targeted youth to reduce alcohol consumption during aquatic activities. This research investigated intended and actual alcohol consumption, particularly during aquatic activities at a Leavers Festival located in the coastal town of Dunsborough, southern Western Australia.MethodIn November 2016, 549 leavers aged 17 or 18 years completed a paper‐based survey over a four‐day period during the Festival.ResultsOverall, 90% of leavers reported intending to drink during the Festival, with expected average daily consumption being seven to nine standard drinks; reported daily consumption was five to six standard drinks (P < 0.001). Of the 29% of leavers who consumed alcohol around water during Leavers, 47% had done so while swimming. About 91% were aware of the campaign “Don't Drink and Drown.”ConclusionAwareness of the “Don't Drink and Drown” campaign and knowledge of risks associated with alcohol consumption and swimming were relatively high. Intention and actual consumption of alcohol did not correlate, with daily consumption less than anticipated.So whatLeavers appear to have a reasonable level of awareness and knowledge of the risks associated with alcohol consumption and aquatic activities, which may reflect the impact of education campaigns. However, this knowledge is not always translated into nonrisky aquatic behaviour.
Do private hospitals outperform public hospitals regarding efficiency, accessibility, and quality of care in the European Union? A literature review
Authors: Kruse Florien M. , Stadhouders Niek W. , Adang Eddy M. , Groenewoud Stef , Jeurissen Patrick P.T. 
Published: March 2018

SummaryEuropean countries have enhanced the scope of private provision within their health care systems. Privatizing services have been suggested as a means to improve access, quality, and efficiency in health care. This raises questions about the relative performance of private hospitals compared with public hospitals. Most systematic reviews that scrutinize the performance of the private hospitals originate from the United States. A systematic overview for Europe is nonexisting. We fill this gap with a systematic realist review comparing the performance of public hospitals to private hospitals on efficiency, accessibility, and quality of care in the European Union. This review synthesizes evidence from Italy, Germany, the United Kingdom, France, Greece, Austria, Spain, and Portugal. Most evidence suggests that public hospitals are at least as efficient as or are more efficient than private hospitals. Accessibility to broader populations is often a matter of concern in private provision: Patients with higher social‐economic backgrounds hold better access to private hospital provision, especially in private parallel systems such as the United Kingdom and Greece. The existing evidence on quality of care is often too diverse to make a conclusive statement. In conclusion, the growth in private hospital provision seems not related to improvements in performance in Europe. Our evidence further suggests that the private (for‐profit) hospital sector seems to react more strongly to (financial) incentives than other provider types. In such cases, policymakers either should very carefully develop adequate incentive structures or be hesitant to accommodate the growth of the private hospital sector.