bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isocostic Acid, a Promising Bioactive Agent from the Essential Oil of Inula viscosa (L.): Insights from Drug Likeness Properties, Molecular Docking and SAR Analysis
Authors: Aissa Ibrahim , Nimbarte Vijaykumar D. , Zardi‐Bergaoui Afifa , Znati Mansour , Flamini Guido , Ascrizzi Roberta , Jannet Hichem Ben 
Published: March 2019

AbstractThe chemical composition of the essential oil (LEO) and its volatile fractions (V1–V10) collected during the hydrodistillation process every 15 min from the fresh leaves of I. viscosa (L.), growing in Tunisia, were analyzed by GC‐FID and GC/MS. Eighty‐two compounds, representing 90.9–99.4 % of the total samples, were identified. The crude essential oil (LEO) and its fractions (V1–V10) were characterized by the presence of a high amount of oxygenated sesquiterpenes (82.7–95.8 %). Isocostic acid (1) was found to be the most abundant component (37.4–83.9 %) and was isolated from the same essential oil over silica gel column chromatography and identified by spectroscopic methods (1H, 13C, DEPT 135 NMR and EI‐MS) and by comparison with literature data. Furthermore, the fresh leaves essential oil (LEO), its volatile fractions (V1–V10) as well as compound 1 were screened for their antibacterial, antityrosinase, anticholinesterase and anti‐5‐lipoxygenase activities. It was found that the isolated compound 1 exhibited an interesting antibacterial activity against Staphylococcus aureus ATCC 25923 (MIC=32 μg/mL) and Enterococcus faecalis ATCC 29212 (MIC=32 μg/mL) and the highest antityrosinase activity (IC50=13.82±0.87 μg/mL). Compound 1 was also found to be able to strongly inhibit 5‐lipoxygenase with an IC50 value of 59.21±0.85 μg/mL. The bioactivity and drug likeness scores of compound 1 were calculated using Molinspiration software and interpreted, and the structure‐activity relationship (SAR) was discussed with the help of molecular docking analysis.
In Situ Enzyme Immobilization with Oxygen‐Sensitive Luminescent Metal–Organic Frameworks to Realize “All‐in‐One” Multifunctions
Authors: Xu Yuzhi , Liu Si‐Yang , Liu Junling , Zhang Li , Chen Danping , Chen Jun , Ma Yingjun , Zhang Jie‐Peng , Dai Zong , Zou Xiaoyong 
Published: March 2019

AbstractInvited for the cover of this issue are Jie‐Peng Zhang, Zong Dai, and co‐workers at Sun Yat‐sen University. The image depicts the harmonious and synergetic combination of MAF‐2 and glucose oxidase (just like the Tai Chi in the background). Read the full text of the article at 10.1002/chem.201806146.
A Highly Active Bidentate Magnesium Catalyst for Amine‐Borane Dehydrocoupling: Kinetic and Mechanistic Studies
Authors: Ried Alexander C. A. , Taylor Laurence J. , Geer Ana M. , Williams Huw E. L. , Lewis William , Blake Alexander J. , Kays Deborah L. 
Published: March 2019

AbstractA magnesium complex (1) featuring a bidentate aminopyridinato ligand is a remarkably selective catalyst for the dehydrocoupling of amine‐boranes. This reaction proceeds to completion with low catalyst loadings (1 mol %) under mild conditions (60 °C), exceeding previously reported s‐block systems in terms of selectivity, rate, and turnover number (TON). Mechanistic studies by in situ NMR analysis reveals the reaction to be first order in both catalyst and substrate. A reaction mechanism is proposed to account for these findings, with the high TON of the catalyst attributed to the bidentate nature of the ligand, which allows for reversible deprotonation of the substrate and regeneration of 1 as a stable resting state.
Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots
Authors: Bernasochi Gabriel B. , Bell James R. , Simpson Evan R. , Delbridge Lea M.D. , Boon Wah Chin 
Published: March 2019

ABSTRACTAs adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) and inflammatory mediators, which have important implications in numerous obesity‐associated diseases. Adipose tissues are broadly characterized as consisting of white, beige, and brown depot types. The endocrine, metabolic, and inflammatory profiles of adipose are depot dependent and influenced by the estrogenic and androgenic status of the adipose tissue. Estrogen receptors mediate both the genomic and nongenomic actions of estrogens and are expressed in the brain, heart, and other peripheral tissues. All three known estrogen receptor α (ERα) and estrogen receptor β (ERβ), and the G‐protein coupled estrogen receptor (GPER/GPR30) are expressed in white adipose and can modulate adipose mass. Expression of each receptor is dependent on depot location, adipose cell type, and estrogen levels. Estrogen receptor expression profiles in beige and brown adipocytes are less well established. This review will discuss the effects of estrogens on the differential deposition of the major adipose tissues and the impact of estrogens within white adipose depots. © 2019 American Physiological Society.Compr Physiol9:457‐475, 2019.
Cholecystokinin (CCK) Regulation of Pancreatic Acinar Cells: Physiological Actions and Signal Transduction Mechanisms
Authors: Williams John A. 
Published: March 2019

ABSTRACTPancreatic acinar cells synthesize and secrete about 20 digestive enzymes and ancillary proteins with the processes that match the supply of these enzymes to their need in digestion being regulated by a number of hormones (CCK, secretin and insulin), neurotransmitters (acetylcholine and VIP) and growth factors (EGF and IGF). Of these regulators, one of the most important and best studied is the gastrointestinal hormone, cholecystokinin (CCK). Furthermore, the acinar cell has become a model for seven transmembrane, heterotrimeric G protein coupled receptors to regulate multiple processes by distinct signal transduction cascades. In this review, we briefly describe the chemistry and physiology of CCK and then consider the major physiological effects of CCK on pancreatic acinar cells. The majority of the review is devoted to the physiologic signaling pathways activated by CCK receptors and heterotrimeric G proteins and the functions they affect. The pathways covered include the traditional second messenger pathways PLC‐IP3‐Ca2+, DAG‐PKC, and AC‐cAMP‐PKA/EPAC that primarily relate to secretion. Then there are the protein‐protein interaction pathways Akt‐mTOR‐S6K, the three major MAPK pathways (ERK, JNK, and p38 MAPK), and Ca2+‐calcineurin‐NFAT pathways that primarily regulate non‐secretory processes including biosynthesis and growth, and several miscellaneous pathways that include the Rho family small G proteins, PKD, FAK, and Src that may regulate both secretory and nonsecretory processes but are not as well understood. © 2019 American Physiological Society.Compr Physiol9:535‐564, 2019.
Photochemistry of Carbonyl Compounds: Application in Metal‐Free Reactions
Authors: Dantas Juliana A. , Correia José Tiago M. , Paixão Marcio W. , Corrêa Arlene G. 
Published: March 2019

AbstractSynthetic organic photochemistry is an efficient and environmentally friendly alternative to assemble biologically and chemically relevant scaffolds. The photon energy allows access to reactive intermediates by using a clean energy source under mild conditions. Moreover, sustainable synthesis can be achieved by using metal‐free photochemistry. In this review, the photochemistry of carbonyl compounds and their application as reagents, catalysts or promoters of metal‐free photochemical transformations are discussed. Fundamental aspects and reactivity of the carbonyl compounds are briefly presented in the introduction section, followed by recent applications of carbonyl compounds in photochemical reactions. The text is organized according to the role of the carbonyl compounds in the process. First, approaches in which carbonyl compounds are employed in stoichiometric or super‐stoichiometric amounts (as reaction substrates or photoinitiators) are described. Thereafter, their application as photocatalysts and photosensitizers are discussed and mechanistic studies are comprehensively presented.
Linkage Abundance and Molecular Weight Characteristics of Technical Lignins by Attenuated Total Reflection‐FTIR Spectroscopy Combined with Multivariate Analysis
Authors: Lancefield Christopher S. , Constant Sandra , de Peinder Peter , Bruijnincx Pieter C. A. 
Published: March 2019

AbstractInvited for this month′s cover is the group of Pieter Bruijnincx at Utrecht University. The image shows how lignin structure information, essential to guide its valorization, can be rapidly obtained from simple IR spectroscopy combined with chemometrics, hence reducing the existing analytical burden. The Full Paper itself is available at 10.1002/cssc.201802809.
Understanding the gap in emergency obstetric and neonatal care in Ghana through the PREventing Maternal And Neonatal Deaths (PREMAND) study
Authors: Kaselitz Elizabeth , James Katherine H. , Aborigo Raymond A. , Agorinya Isaiah , Moyer Cheryl A. , Williams John 
Published: March 2019

AbstractObjectiveTo explore basic and comprehensive emergency obstetric service provision across four districts in rural northern Ghana, and whether women were more likely to deliver at facilities with more skilled care.MethodsField workers geo‐coded all health facilities in East Mamprusi, Sissala East, Kassena Nankana Municipal, and Kassena Nankana West districts, and administered surveys to assess providers and emergency obstetric care available. Data were also prospectively collected on delivery locations of women and neonates who died, or nearly died (near misses), between September 1, 2015 and April 30, 2017.ResultsThere were 14 physicians for a population of nearly 360 000 women. Six (6%) facilities could provide basic emergency care, and 3 (3%) could provide comprehensive care. Services were distributed unequally, with 6 (67%) of the emergency facilities located in the least populated district. Among the sample of women and neonates who died or nearly died, 175 (39%) delivered at locations unable to provide basic emergency services.ConclusionAccess to emergency obstetric and neonatal care was distributed inequitably across these districts, suggesting the need to revisit geographic placement of facilities relative to population. The study also raised the question of how to ensure facilities are equipped to respond to emergencies.
miR‐4458 regulates cell proliferation and apoptosis through targeting SOCS1 in triple‐negative breast cancer
Authors: Liu Xiaomeng , Wang Jianling , Zhang Guochao 
Published: March 2019

AbstractOur previous study has suggested suppressor of cytokine signaling 1 (SOCS1) is associated with clinical progression and functions as an oncogenic role to regulate cell proliferation and apoptosis in triple‐negative breast cancer (TNBC). Several microRNA‐messenger RNA (miRNA‐mRNA) relationship databases show SOCS1 is identified as a direct target gene of miRNA‐4458 (miR‐4458). The purpose of this study was to study the relationship between miR‐4458 and SOCS1 in TNBC. In our results, miR‐4458 expression was decreased in TNBC tissues and cells compared with adjacent normal tissues and normal mammary epithelial cell line, respectively. Moreover, miR‐4458 directly bound to SOCS1, and negatively regulated SOCS1 mRNA and protein expression. Furthermore, miR‐4458 suppressed cell proliferation and promote cell apoptosis through regulating SOCS1 in TNBC. Besides, levels of miR‐4458 expression in patients with advanced clinical stage were obviously lower than in patients with early clinical stage. In conclusion, miR‐4458 mediates SOCS1 to play a tumor‐suppressive role in TNBC.
Cationic liposome codelivering PI3K pathway regulator improves the response of BRCA1‐deficient breast cancer cells to PARP1 inhibition
Authors: Zhang Haipeng , Yu Na , Chen Yan , Yan Kaowen , Wang Xiaozhen 
Published: March 2019

AbstractAlthough some progresses have been made in breast cancer therapy, effective treatment for BRCA1‐deficient breast cancer remains to be a great challenge. It has been demonstrated that the PI3K pathway is inappropriately activated in BRCA1‐deficient breast cancers which can be downregulated by microRNA 451 (miR‐451). In addition, although PARP1 inhibitors showed relatively positive results in both preclinical and clinical studies, additional efforts to decrease drug resistance as well as reduce systematic toxicity need to be addressed. To this end, by encapsulating the miR‐451 mimic and PARP1 inhibitor in the same cationic liposome, we examined the potential of enhancing the response of PARP1 inhibition on BRCA1‐deficient breast cancer by regulating the PI3K pathway. Our results revealed that in BRCA1‐deficient human breast cancer cell line, PARP1 inhibition resulted in DNA damage with viability decrease, G2/M arrest as well as apoptosis. In contrast, single PI3K inhibition induced G1 arrest along with retarded cell proliferation. However, it was noted that combination of PARP inhibitor and PI3K regulator could exert synergetic function to evidently decrease cell proliferation compared with PARP inhibition alone, which was also confirmed by in vivo antitumor assay using xenograft tumor models. Collectively, our results offer an alternative but superior strategy for the therapy of BRCA1‐deficient human breast cancers which may benefit the clinical applications.
Acute effect of an amino acid mixture in the rat glycemic profile
Authors: Pena Maria J. , Guerreiro Susana G. , Rocha Júlio C. , Morais Tiago , Pereira Sofia S. , Monteiro Mariana P. , Borges Nuno 
Published: March 2019

AbstractAmino acid mixtures (AAM) are protein substitutes used for phenylketonuria treatment, but their metabolic effects have not been well characterized. The objective of this study was to compare the acute glycemic response to free amino acids (free AA) from AAM with the response to intact protein (iProtein). Male Wistar rats (n = 14) were administered by gavage a bolus of free AA (n = 7) or iProtein as albumin (n = 7) containing equivalent amounts of nitrogen. Blood glucose and insulin levels were measured at baseline and 15, 30, 60 and 120 minutes later, when gut GLP‐1 content and pancreatic insulin, GLP‐1 receptor and Ki67 expression were quantified at 120 minutes time point. After AAM, glucose area under the curve (free AA vs iProtein; P < 0.01), serum insulin levels at 120 minutes (free AA vs iProtein;
P < 0.05), colon GLP‐1 content (free AA vs iProtein;
P < 0.01), pancreatic GLP‐1 receptor (free AA vs iProtein;
P < 0.01) and insulin expression (free AA vs iProtein;
p < 0.01) were significantly lower as compared with iProtein. AAM increased Ki67 expression in pancreatic islets (free AA vs iProtein;
P < 0.05). In conclusion, this study demonstrated that acute response to AAM differs from iProtein and is characterized by a lower glucose excursion, along with a decrease in gut GLP‐1 and pancreatic GLP‐1 receptor and insulin. This data suggests the modulation of glycemia by free AA is mediated by the incretin axis.
A comparison of noninvasive methods for early detection of hemorrhage: Inferior vena cava ultrasonography and spectrophotometric hemoglobin levels
Authors: Yamanoglu Adnan , Celebi Yamanoglu Nalan Gokce , Sogut Ozgur , Yigit Mehmet , Tas Demet , Saclı Neslihan , Topal Fatih Esad 
Published: March 2019

AbstractObjectivesBlood hemoglobin concentration measurements using a spectrophotometric method (SpHb), and inferior vena cava ultrasonography (IVC‐US) are noninvasive methods used to follow‐up hemorrhages. We compared their efficacy using voluntary blood donation as a model of moderate (approx. 500 mL) blood loss.MethodsIn this prospective observational study enrolling blood‐donor volunteers (BD) and matched controls, we recorded SpHb, IVC diameters, and vital signs. Changes in variables from baseline were compared between BD and controls using the paired t test and Wilcoxon signed rank test.ResultsWe included 118 subjects in the BD group and 95 healthy subjects in the control group. Changes in IVC maximum diameter, IVC minimum diameter, pulse rate, mean arterial pressure, pulse pressure, and shock index, but not in other variables, were significantly different in the BD and the control group (P < 0.05). IVCmax ≥1.1 mm yielded a 74% sensitivity and 77% specificity (PPV 79.8%, NPV 70.2%) in detecting early hemorrhage. With these cutoff values, IVCmax or PR reached a 90% sensitivity, while IVCmin and PR reached 98% specificity.ConclusionsIVC ultrasound may be superior to SpHb in predicting blood loss and may be useful in addition to vital signs for its follow‐up.
Investigating GABA concentrations measured with macromolecule suppressed and unsuppressed MEGA‐PRESS MR spectroscopy and their relationship with BOLD responses in the occipital cortex
Authors: Duncan Niall W. , Zhang Jianfeng , Northoff Georg , Weng Xuchu 
Published: March 2019

BackgroundA combination of magnetic resonance spectroscopy (MRS) and functional (f)MRI is a promising method for studying brain activity. Negative results have, however, produced uncertainty as to the validity of the approach. Using a MEGA‐PRESS sequence adapted to suppress the macromolecule signal (GABA–) has been suggested as a key methodological improvement, but there is some doubt as to the relationship between such estimates and those from the standard sequence (GABA+), making interpretation difficult.PurposeTo investigate the relationship between GABA+ and GABA– estimates from the posterior cingulate and occipital cortices. The second aim was to test for a correlation between occipital GABA and blood oxygenation level‐dependent (BOLD) responses in the visual cortex to establish which of the two MEGA‐PRESS sequences was more related to the functional responses.Study TypeProspective.SubjectsThirty‐one healthy participants.Field Strength/Sequence3T/single‐voxel 1H‐MRS and gradient‐echo echo planar imaging (EPI).AssessmentGABA estimates were made using the Gannet toolbox. fMRI data were analyzed with FSL and Python scripts.Statistical TestRelationships between different variables were tested with Pearson's correlation.ResultsGABA+ and GABA– concentrations were found to be correlated in both regions (r = 0.52, 95% confidence interval [CI] = 0.35 0.66, pFDR = 0.002). No relationship was found between either the GABA+ or the GABA– concentrations and the amplitude of the BOLD response in the occipital cortex (GABA+, r = –0.14, pFDR > 0.1; GABA–, r = –0.29, pFDR >0.1). However, adding these results to those of prior studies in a meta‐analysis of correlation coefficients did provide overall support for a negative correlation between GABA and BOLD response amplitudes (r = –0.39, 95% CI = –0.15–0.64).Data ConclusionThe current findings highlight potential methodological issues that continue to interfere with relating MRS GABA estimates with fMRI responses but, taken in sum, provide support for this general approach.Level of Evidence: 1Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2019;50:1285–1294.
Can shared value and entrepreneurship contribute to SME development within rural locations?
Authors: Blanchard Kevin , Gray David 
Published: March 2019

AbstractThe study tests the view that shared value indices are or similar to that of entrepreneurial awareness, both in their tacit and strategic decision‐making abilities. A survey of 23 rural and remote rural businesses was carried in order to examine how and why they made specific judgments within their daily and longer‐term business decision making. The literature indicates that both concepts do have similar traits/characteristically, and also that the two areas may be both mutually similar and have synergies founded within their desired outcomes and centered on the business community. The concept of shared value as a mechanism for profit generating is accepted, but this is tempered with the ability to bring together visions of a shared nature within both customer base and business. In such circumstances the synergistic effect of such strategies becomes blurred and transcends into other business disciplines, which may have very similar outcomes. The survey found that both areas of test shared a high level of similarity, but geographical location had no effect on the level of application.
Cover Image, Volume 99, Issue 6
Authors: Su Ruihua , Li Tangfei , Fan Daming , Huang Jianlian , Zhao Jianxin , Yan Bowen , Zhou Wenguo , Zhang Wenhai , Zhang Hao 
Published: March 2019

The cover image is based on the Research Article The inhibition mechanism of Є‐polylysine against Bacillus cereus emerging in surimi gel during refrigerated storage by Ruihua Su et al., DOI: 10.1002/jsfa.9505.
image
Characterization of permethrin resistance in a Musca domestica strain: resistance development, cross‐resistance potential and realized heritability
Authors: Khan Hafiz Azhar Ali 
Published: March 2019

AbstractBackgroundPermethrin (a pyrethroid) has been recommended for the management of a number of insect pests, including Musca domestica. Recently, resistance to permethrin has been reported from the Punjab province, Pakistan, which necessitates the need to manage the resistance problem. For this reason, a field strain of M. domestica was selected with permethrin for ten consecutive generations (G1–G10) to determine the risk assessment, the rapidity with which permethrin resistance can develop, and the presence or absence of the cross‐resistance phenomenon.ResultsThe results revealed that permethrin resistance increased very quickly in response to selection experiments. The resistance ratio (RR) value increased by 16.04‐ to 605.92‐fold and the LD50 value increased by 100.22 to 3787.08 ng fly−1 after selection experiments. Moreover, the increase in LD50 value remained stable when the selected strain (Perm‐SEL) was cultured in the absence of permethrin for the next five generations (G11–G15). The results revealed the possibility of minor cross‐resistance in the Perm‐SEL strain with β‐cyfluthrin and deltamethrin, and lack of cross‐resistance with imidacloprid and spinosad. The realized heritability (h2) value for the Perm‐SEL strain was 0.23. Assuming a mean slope value of 1.27 and an h2 value of 0.23, then ten to four generations would be estimated for a 10‐fold increase in the LD50 values at 50–90% selection intensity, respectively.ConclusionThe results of present study revealed high risk for permethrin resistance development under continuous selection pressure. Permethrin resistance developed very quickly under laboratory conditions, which might reflect the likelihood of resistance evolution in field conditions if permethrin selection pressure holds for a long time. © 2019 Society of Chemical Industry