bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hot star extension to theHubbleSpace Telescope stellar spectral library
Authors: Khan Islam , Worthey Guy 
Published: March 2018

Context.Libraries of stellar spectra find many uses in astrophysics, from photometric calibration to stellar population synthesis.Aims.We present low resolution spectra of 40 stars from 0.2μm (ultraviolet) to 1.0μm (near infrared) with excellent fluxing. The stars include normal O-type stars, helium-burning stars, and post-asymptotic giant branch (PAGB) stars.Methods.Spectra were obtained with the Space Telescope Imaging Spectrograph (STIS) installed in theHubbleSpace Telescope (HST) using three low resolution gratings, G230LB, G430L, and G750L. Cosmic ray hits and fringing in the red were corrected. A correction for scattered light was applied, significant only for our coolest stars. Cross-correlation was used to bring the spectra to a common, final, zero velocity wavelength scale. Finally, synthetic stellar spectra were used to estimate line of sight dust extinction to each star, and a five-parameter dust extinction model was fit, or a one-parameter fit in the case of low extinction.Results.These spectra dovetail with the similar Next Generation Stellar Library (NGSL) spectra, extending the NGSL’s coverage of stellar parameters, and extending to helium burning stars and stars that do not fuse.Conclusions.The fitted dust extinction model showed considerable variation from star to star, indicating variations in dust properties for different lines of sight. Interstellar absorption lines are present in most stars, notably MgII.
Tumor der Fingerbeugesehne - Ein klarer Fall?
Authors: Schöwe Christin , Jung Florian johannes , Sproedt Julia 
Published: March 2018

FallberichtEin 11-jähriger Junge wurde zur Abklärung einer Raumforderung palmar am linken Zeigefinger in die handchirurgische Sprechstunde zugewiesen. Die knotige Veränderung
war dem Patienten durch intermittierende Beschwerden beim Gitarre spielen aufgefallen. Ein Schnellen des Zeigefingers wurde nicht beobachtet. Ein auslösendes
Unfallereignis oder eine Schnittverletzung waren nicht erinnerlich.
Synthesis of Aryl Trifluoromethyl Ketones
Authors: Wu Wei , Weng Zhiqiang 
Published: March 2018

Trifluoromethyl ketones have recently been attracting considerable attention because they represent powerful synthetic building blocks with potential pharmaceutical applications. This short review provides an overview of recent development in the synthesis of aryl trifluoromethyl ketones with novel reagents.1	Introduction2	Various Methods for the Synthesis of Aryl Trifluoromethyl Ketones­2.1	Oxidation of Trifluoromethyl Alcohols2.2	Nucleophilic Trifluoromethylation Reactions2.3	Electrophilic-Type Reactions2.4	Recently Developed Direct Trifluoroacetylation3	Conclusions
Primary Graft Dysfunction (PGD) Following Lung Transplantation
Authors: Shah Rupal , Diamond Joshua 
Published: March 2018

AbstractPrimary graft dysfunction (PGD) is a form of acute lung injury that results from ischemia reperfusion injury (IRI) and is the major cause of early posttransplant morbidity and mortality. Patients who survive PGD have decreased quality of life, an increased risk of chronic lung allograft dysfunction, specifically bronchiolitis obliterans syndrome, and a significantly increased risk of death. In 2017, the International Society for Heart and Lung Transplantation released updated consensus statements on the PGD definition, most up-to-date PGD risk factors, mechanisms of PGD development, and the state-of-the-art for PGD therapeutics. Risk factor identification has led to the development of PGD predictive algorithms, although their clinical utility remains limited. Ongoing areas of controversy and discussion include further refinements to the PGD grading scheme to account for technologic advances such as extracorporeal membrane oxygenation and the increased utilization of high flow nasal cannula, the use of PGD as an outcome measure in clinical trials of ex vivo lung perfusion, enhancement of predictive algorithms incorporating biochemical risk factors, and the need for development of therapies targeted at improving PGD outcomes.
Academic Performance of Children with ADHD in Ile Ife, South West, Nigeria
Authors: OKE Oluwasola Julius , Adejuyigbe Ebunoluwa Aderonke , Oseni Saheed B. , Mosaku Kolawole S. 
Published: March 2018

AbstractAttention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder that affects attention and concentration of children. In Africa, there is a lack of information on academic performance of children with ADHD. This article aims to (1) determine the academic performance and intelligent quotient (IQ) of pupils with ADHD, (2) compare the academic performance and IQ of children with ADHD to those without ADHD, and (3) determine other factors affecting academic performance in children with ADHD. A community-based cross-sectional study was conducted in Ile Ife among pupils aged 5 to 12 years. They were screened with Disruptive Behavioral Disorder Rating Scale, IQs determined with the Draw-A-Person test (DAPT), the academic performance determined with academic performance questionnaire (APQ), and continuous assessment (CA) score for 2013/2014 session recorded. A total of 32.3% of 65 pupils with ADHD had low CA score, while 9.6% of 1,320 pupils without ADHD had low CA score. The CA score of pupils with ADHD was significantly lower (χ2
= 36.875, p = 0.001), particularly among older children aged 9 to 12 years (χ
2 = 4.135, p = 0.042). A total of 46.2% of 65 pupils with ADHD had subnormal IQ, while 47.2% of 1,320 pupils without ADHD had subnormal IQ. There was no significant difference between the IQ of children with ADHD and their peers without ADHD (χ2
= 0.023, p = 0.879). Children with ADHD had similar IQ as their peers without ADHD but lower CA score. The low academic performance in pupils with ADHD could be attributed to inattentiveness in the affected pupils.
Text Mining and Automation for Processing of Patient Referrals
Authors: Todd James , Richards Brent , Vanstone Bruce , Gepp Adrian 
Published: March 2018

Background Various tasks within health care processes are repetitive and time-consuming, requiring personnel who could be better utilized elsewhere. The task of assigning clinical urgency categories to internal patient referrals is one such case of a time-consuming process, which may be amenable to automation through the application of text mining and natural language processing (NLP) techniques.
Objective This article aims to trial and evaluate a pilot study for the first component of the task—determining reasons for referrals.
Methods Text is extracted from scanned patient referrals before being processed to remove nonsensical symbols and identify key information. The processed data are compared against a list of conditions that represent possible reasons for referral. Similarity scores are used as a measure of overlap in terms used in the processed data and the condition list.
Results This pilot study was successful, and results indicate that it would be valuable for future research to develop a more sophisticated classification model for determining reasons for referrals. Issues encountered in the pilot study and methods of addressing them were outlined and should be of use to researchers working on similar problems.
Conclusion This pilot study successfully demonstrated that there is potential for automating the assignment of reasons for referrals and provides a foundation for further work to build on. This study also outlined a potential application of text mining and NLP to automating a manual task in hospitals to save time of human resources.
Sagittale Balance und posttraumatische Kyphose
Authors: Pingel Andreas , Franke Jörg , Kandziora Frank 
Published: March 2018

ZusammenfassungDieser Übersichtsartikel soll in die Grundlagen der sagittalen Balance der Wirbelsäule einführen, die diagnostischen Maßnahmen und insbesondere die Messmethoden des Wirbelsäulenprofils und der Beckenparameter darstellen sowie als typisches Krankheitsbild einer sagittalen Deformität die posttraumatische Kyphose vorstellen. In einem zweiten Teil in einem der folgenden Hefte werden die spezifischen konservativen und operativen Behandlungsmethoden von sagittalen Profilstörungen unter besonderer Berücksichtigung der posttraumatischen kyphotischen Wirbelsäulendeformitäten beschrieben.
Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis
Authors: Zhao Linjie , Huang Shuang , Mei Shenglin , Yang Zhengnan , Xu Lian , Zhou Nianxin , Yang Qilian , Shen Qiuhong , Wang Wei , Le Xiaobing , Lau Wayne Bond , Lau Bonnie , Wang Xin , Yi Tao , Zhao Xia , Wei Yuquan , Warner Margaret , Gustafsson Jan-Åke , Zhou Shengtao 
Published: March 2018

Significance
Cancer metastases have caused the major mortality rate for cancer patients, with limited options of treatment and unsatisfactory therapeutic efficacy. Unlike the tumor-promoting role of estrogen receptor (ER)α, ERβ has shown potent antitumor effects in many cancers. In this study, we showed that the selective ERβ agonist LY500307 could potently suppress lung metastasis of cancer by recruitment of antitumor neutrophils to the metastatic niche. These chemotactic effects of LY500307 for neutrophils were primarily mediated by ERβ activation-induced IL-1β release by the tumor cells. Our study provides the rationale that pharmacological activation of ERβ could augment innate immunity to suppress cancer metastatic colonization to lung, implicating the potential use of selective ERβ agonists for the treatment of cancer patients with metastasis.
Rock Physics and Petrographic Parameters Relationship Within Siliciclastic Rocks: Quartz Sandstone Outcrop Study Case
Authors: Syafriyono S , Caesario D , Swastika A , Adlan Q , Syafri I , Abdurrokhim A , Mardiana U , Mohamad F , Alfadli M K , Sari V M 
Published: March 2018

Abstract
Rock physical parameters value (Vp and Vs) is one of fundamental aspects in reservoir characterization as a tool to detect rock heterogenity. Its response is depend on several reservoir conditions such as lithology, pressure and reservoir fluids. The value of Vp and Vs is controlled by grain contact and contact stiffness, a function of clay mineral content and porosity also affected by mineral composition. The study about Vp and Vs response within sandstone and its relationship with petrographic parameters has become important to define anisotrophy of reservoir characteristics distribution and could give a better understanding about local diagenesis that influence clastic reservoir properties. Petrographic analysis and Vp-Vs calculation was carried out to 12 core sample which is obtained by hand-drilling of the outcrop in Sukabumi area, West Java as a part of Bayah Formation. Data processing and interpretation of sedimentary vertical succession showing that this outcrop comprises of 3 major sandstone layers indicating fluvial depositional environment. As stated before, there are 4 petrographic parameters (sorting, roundness, clay mineral content, and grain contact) which are responsible to the differences of shear wave and compressional wave value in this outcrop. Lithology with poor-sorted and well- roundness has Vp value lower than well-sorted and poor-roundness (sub-angular) grain. For the sample with high clay content, Vp value is ranging from 1681 to 2000 m/s and could be getting high until 2190 to 2714 m/s in low clay content sample even though the presence of clay minerals cannot be defined neither as matrix nor cement. The whole sample have suture grain contact indicating telogenesis regime whereas facies has no relationship with Vp and Vs value because of the different type of facies show similar petrographic parameters after diagenesis.
Genome-by-genome approach for fast bacterial genealogical relationship evaluation
Authors: Zhang Ji , Xiong Yanwen , Rogers Lynn , Carter Glen P , French Nigel 
Published: March 2018

Abstract

Motivation
Large-scale whole-genome sequencing dataset-based studies are becoming increasingly common in pathogen surveillance and outbreak investigations. A highly discriminative and time-efficient bioinformatics tool is needed to transform large amounts of sequencing data into usable biological information. To replace the intuitive, yet inefficient, way of gene-by-gene allele calling algorithm, a new algorithm using genome-by-genome approach was developed.

Results
Tests showed that the program equipped with the new algorithm achieved significant improvements in allele calling efficiency compared to a conventional gene-by-gene approach. The new program, Fast-GeP, rendered a fast and easy way to infer high-resolution genealogical relationships between bacterial isolates using whole-genome sequencing data.

Availability and implementation
FAST-GeP is freely available from: https://github.com/jizhang-nz/fast-GeP.

Supplementary information
Supplementary data are available at Bioinformatics online.
HE 0430–2457: a post-merger extremely low-mass pre-white dwarf in a wide binary posing as an extreme horizontal branch star
Authors: Vos Joris , Zorotovic Monica , Vučković Maja , Schreiber Matthias R , Østensen Roy 
Published: March 2018

Abstract
We report the discovery of HE 0430–2457, the first extremely low-mass pre-white dwarf (ELM pre-WD) in a long period binary (P = 771 ± 3 d). The spectroscopic parameters of the primary are determined to be Teff = 26 200 ± 1500 K and log g = 5.40 ± 0.35, placing it in the region occupied by core He-burning hot subdwarf B stars. By comparing the spectroscopic parameters of the K-type companion to stellar models, and using the mass ratio, the mass of the hot primary is determined to be 0.23 M⊙. Given that this is too low for core He-burning, the primary in HE 0430–2457 is not an extreme horizontal branch (EHB) star but a pre-WD of the ELM type. As the lifetime of ELM pre-WDs in this region of the Hertzsprung Russel diagram populated by EHBs is thought to be very short, they are not considered to be part of the observed EHBs. However, the discovery of this system indicates that the percentage of ELM pre-WDs in the observed EHB population might be higher than previously thought. Binary evolution models indicate that HE 0430–2457 is likely formed by a merger of the inner binary in a hierarchical triple system.
Deep Brain Stimulation of the Pedunculopontine Nucleus Area in Parkinson Disease: MRI-Based Anatomoclinical Correlations and Optimal Target
Authors: Goetz Laurent , Bhattacharjee Manik , Ferraye Murielle U , Fraix Valérie , Maineri Carina , Nosko Daniela , Fenoy Albert J , Piallat Brigitte , Torres Napoléon , Krainik Alexandre , Seigneuret Eric , David Olivier , Parent Martin , Parent André , Pollak Pierre , Benabid Alim -Louis , Debu Bettina , Chabardès Stéphan 
Published: March 2018

Abstract

BACKGROUND
Experimental studies led to testing of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) as a new therapy to treat freezing of gait (FOG) in Parkinson disease (PD). Despite promising initial results fueling a growing interest toward that approach, several clinical studies reported heterogeneity in patient responses. Variation in the position of electrode contacts within the rostral brainstem likely contributes to such heterogeneity.

OBJECTIVE
To provide anatomoclinical correlations of the effect of DBS of the caudal mesencephalic reticular formation (cMRF) including the PPN to treat FOG by comparing the normalized positions of the active contacts among a series of 11 patients at 1- and 2-yr follow-up and to provide an optimal target through an open-label study.

METHODS
We defined a brainstem normalized coordinate system in relation to the pontomesencephalic junction. Clinical evaluations were based on a composite score using objective motor measurements and questionnaires allowing classification of patients as “bad responders” (2 patients), “mild responders” (1 patient) and “good responders” (6 patients). Two patients, whose long-term evaluation could not be completed, were excluded from the analysis.

RESULTS
Most effective DBS electrode contacts to treat FOG in PD patients were located in the posterior part of the cMRF (encompassing the posterior PPN and cuneiform nucleus) at the level of the pontomesencephalic junction.

CONCLUSION
In the present exploratory study, we performed an anatomoclinical analysis using a new coordinate system adapted to the brainstem in 9 patients who underwent PPN area DBS. We propose an optimal DBS target that allows a safe and efficient electrode implantation in the cMRF.
The Application of the Novel Grading Scale (Lawton-Young Grading System) to Predict the Outcome of Brain Arteriovenous Malformation
Authors: Hafez Ahmad , Koroknay-Pál Päivi , Oulasvirta Elias , Elseoud Ahmed Abou , Lawton Michael T , Niemelä Mika , Laakso Aki 
Published: March 2018

Abstract

BACKGROUND
A supplementary grading scale (Supplemented Spetzler-Martin grade, Supp-SM) was introduced in 2010 as a refinement of the SM system to improve preoperative risk prediction of brain arteriovenous malformations (AVMs).

OBJECTIVE
To determine the ability to predict surgical outcomes using the Supp-SM grading scale.

METHODS
This retrospective study was conducted on 200 patients admitted to the Helsinki University Hospital between 2000 and 2014. The validity of the Supp-SM and SM grading systems was compared using the area under the receiver operating characteristic (AUROC) curves, with respect to the change between preoperative and early (3-4 mo) as well as final postoperative modified Rankin Scale (mRS) scores.

RESULTS
The performance of the Supp-SM was superior to that of the SM grading scale in the early follow-up (3-4 mo): AUROC = 0.57 (95% confidence interval [CI]: 0.49-0.65) for SM and AUROC = 0.67 (95% CI: 0.60-0.75) for Supp-SM. The Supp-SM performance continued improving over SM at the late follow-up: AUROC = 0.63 (95% CI: 0.55-0.71) for SM and AUROC = 0.70 (95% CI: 0.62-0.77) for Supp-SM. The perforating artery supply, which is not part of either grading system, plays an important role in the early follow-up outcome (P = .008; odds ratio: 2.95; 95% CI: 1.32-6.55) and in the late follow-up outcome (P < .001; odds ratio: 5.89; 95% CI: 2.49-13.91).

CONCLUSION
The Supp-SM grading system improves the outcome prediction accuracy and is a feasible alternative to the SMS, even for series with higher proportion of high-grade AVMs. However, perforators play important role on the outcome.
Corynebacterium Bone and Joint Infection (BJI): A Retrospective Cohort Study in a Reference Center for BJI Management
Authors: Ferry Tristan , Chauvelot Pierre , Triffault-Fillit Claire , Braun Evelyne , Perpoint Thomas , Laurent Frederic , Fessy Michel-Henri , Lustig Sébastien , Chidiac Christian , Valour Florent ,   Lyon BJI Study group
Published: March 2018

Abstract

Background
Corynebacterium is a rare etiologic agent of BJI. We aimed to describe this rare clinical condition and to assess treatment failure determinants.

Methods
All adult patients with proven Corynebacterium BJI (i.e., consistent clinical/radiological signs, AND ≥2 reliable positive bacteriological samples, AND treated as such) were included in a retrospective cohort study. After cohort description, determinants of treatment failure (i.e., infection persistence, relapse, requirement of additional surgical procedure, and BJI-related death) were determined using stepwise logistic regression and Kaplan-–Meier curve analysis.

Results
The 51 included BJI were more frequently chronic (88.2%), orthopaedic device related (ODI, 74.5%) and polymicrobial (78.4%). Surgery was performed in 92.2% of cases, and considered as appropriate in 76.5% of them. The main first-line antimicrobials were glycopeptides (68.6%), β-lactams (50%), and/or clindamycin (10.0%). Three (5.9%) patients received daptomycin as part of first-line regimen, and 8 (15.7%) at any point of treatment. After a follow-up of 60.7 (IQR 30.1–115.1) weeks, 20 (39.2%) treatment failures were observed, including 4 (20%) Corynebacterium-documented relapse. Independent risk factors were initial biological inflammatory syndrome (OR 16.1; P = 0,030) and inappropriate surgical management (OR 7.481; P = 0.036). Interestingly, all patients receiving daptomycin as part of first-line regimen failed (P &lt; 0.001), including one patient with a Corynebacterium-documented relapse with a daptomycin increased MIC. Among patients with ODI, survival curve analysis disclosed a worst prognosis in case of prosthetic joint infection (P = 0.030), unappropriate surgical management (P = 0.029) and daptomycin use as first-line regimen (P &lt; 0.001).

Conclusion
Corynebacterium BJI is a poorly known condition, frequently chronic, and polymicrobial. An important rate of failure was observed, associated with inappropriate surgical management and daptomycin use as part of first-line regimen. As described for other clinical conditions such as infective endocarditis, daptomycin should be avoid or used in combination therapy to prevent resistance selection and treatment failure.

Disclosures
T. Ferry, HERAEUS: Consultant, Speaker honorarium. S. Lustig, Heraeus: Consultant, Consulting fee
Management and treatment of animal bites
Authors: Hurt John B. , Maday Kristopher R. 
Published: March 2018

ABSTRACT
Animal bites account for 1% of ED visits and more than $50 million in healthcare costs annually in the United States. Managing bite wounds can be challenging and providers must consider the patient's tetanus status, species of animal inflicting the bite, and infection risk. This article describes treatment and care of bites and when rabies prophylaxis is indicated.
Update on surgical site infections
Authors: Borchardt Roy A. , Tzizik Dan 
Published: March 2018

ABSTRACT
Surgical site infections (SSIs) occur near or at the incision site and/or deeper underlying tissue spaces and organs within 30 days of a surgical procedure (or up to 90 days for implanted prosthetics). SSIs are the most common healthcare-associated infections experienced by patients who undergo surgery, increase overall cost and length of hospital stay, and are largely preventable. This article reviews the recently updated CDC guidelines for preventing SSIs.
The Pseudo-Pelger Huët Cell as a Retrospective Dosimeter: Analysis of a Radium Dial Painter Cohort
Authors: Goans Ronald E. , Toohey Richard E. , Iddins Carol J. , McComish Stacey L. , Tolmachev Sergei Y. , Dainiak Nicholas 
Published: March 2018

Abstract
Recently, the pseudo-Pelger Huët anomaly in peripheral blood neutrophils has been described as a new radiation-induced, stable biomarker. In this study, pseudo-Pelger Huët anomaly was examined in peripheral blood slides from a cohort of 166 former radium dial painters and ancillary personnel in the radium dial industry, 35 of whom had a marrow dose of zero above background. Members of the radium dial painter cohort ingested 226Ra and 228Ra at an early age (average age 20.6 ± 5.4 y; range 13–40 y) during the years 1914–1955. Exposure duration ranged from 1–1,820 wk with marrow dose 1.5–6,750 mGy. Pseudo-Pelger Huët anomaly expressed as a percentage of total neutrophils in this cohort rises in a sigmoidal fashion over five decades of red marrow dose. Six subjects in this cohort eventually developed malignancies: five osteosarcomas and one mastoid cell neoplasm. The pseudo-Pelger Huët anomaly percentage in these cases of neoplasm increases with marrow dose and is best fit with a sigmoid function, suggestive of a threshold effect. No sarcomas are seen for a marrow dose under 2 Gy. These results indicate that pseudo-Pelger Huët anomaly in peripheral blood is a reasonable surrogate for the estimation of alpha dose to bone marrow in historic radiation cases. Hypotheses are discussed to explain late (months to years), early (hours to days), and intermediate (weeks to months) effects of ionizing radiation, respectively, on the expression of genes encoding inner nuclear membrane proteins and their receptors, on the structure and function of nuclear membrane proteins and lipids, and on cytokinesis through chromatin bridge formation.