bluuebunny/crossref_metadata_2025_split huggingface dataset:
Release of Munitions Constituents in Aquatic Environments Under Realistic Scenarios and Validation of Polar Organic Chemical Integrative Samplers for Monitoring
Authors: Lotufo Guilherme R. , George Robert D. , Belden Jason B. , Woodley Christa , Smith David L. , Rosen Gunther 
Published: July 2019

Abstract
Munitions constituents (MC) may be released into aquatic environments as a result of underwater military munitions (UWMM) corrosion and breach. The present study investigated the release of 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) from Composition B fragments under 2 realistic exposure scenarios in a large flume with flow set at 15 cm/s: the first represented the release of MC from fully exposed Composition B, and the second represented release through a small hole, simulating a breached munition. Release of MC through a small hole was approximately 10 times lower than from exposed Composition B, demonstrating the strong influence of exposure to flow on release. The rate of release of MC into the flume was similar to that previously reported in a related field experiment, but a similar mass loss resulted in MC concentration in the field &gt;300 times lower, likely by the dilution effect of hydrodynamic transport. The present study corroborates previous findings of release of MC at UWMM sites resulting in concentrations below the toxicity threshold to most species. In the flume water, MC was quantified using frequent grab sampling and polar organic chemical integrative samplers (POCIS). For TNT, POCIS-estimated time-weighted average concentrations were up to 40% higher than those derived from grab samples, whereas for RDX differences were 6% or less, demonstrating that POCIS provide reliable temporal integration of changing environmental concentrations for common MC. Environ Toxicol Chem 2019;38:2383–2391. Published 2019 Wiley Periodicals Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America
A labelled ocean SAR imagery dataset of ten geophysical phenomena from Sentinel‐1 wave mode
Authors: Wang Chen , Mouche Alexis , Tandeo Pierre , Stopa Justin E. , Longépé Nicolas , Erhard Guillaume , Foster Ralph C. , Vandemark Douglas , Chapron Bertrand 
Published: July 2019

AbstractThe Sentinel‐1 mission is part of the European Copernicus program aiming at providing observations for Land, Marine and Atmosphere Monitoring, Emergency Management, Security and Climate Change. It is a constellation of two (Sentinel‐1 A and B) Synthetic Aperture Radar (SAR) satellites. The SAR wave mode (WV) routinely collects high‐resolution SAR images of the ocean surface during day and night and through clouds. In this study, a subset of more than 37,000 SAR images is labelled corresponding to ten geophysical phenomena, including both oceanic and meteorologic features. These images cover the entire open ocean and are manually selected from Sentinel‐1A WV acquisitions in 2016. For each image, only one prevalent geophysical phenomenon with its prescribed signature and texture is selected for labelling. The SAR images are processed into a quick‐look image provided in the formats of PNG and GeoTIFF as well as the associated labels. They are convenient for both visual inspection and machine learning‐based methods exploitation. The proposed dataset is the first one involving different oceanic or atmospheric phenomena over the open ocean. It seeks to foster the development of strategies or approaches for massive ocean SAR image analysis. A key objective was to allow exploiting the full potential of Sentinel‐1 WV SAR acquisitions, which are about 60,000 images per satellite per month and freely available. Such a dataset may be of value to a wide range of users and communities in deep learning, remote sensing, oceanography and meteorology.
Synthesis of Benzazepinones via Intramolecular Cyclization Involving Ketene Iminium Intermediates
Authors: Kolleth Amandine , Dagoneau Dylan , Quinodoz Pierre , Lumbroso Alexandre , Avanthay Mickael , Catak Saron , Sulzer‐Mossé Sarah , De Mesmaeker Alain 
Published: July 2019

AbstractHerein, we describe a very straightforward and metal free method for the synthesis of benzazepinones through an intramolecular cyclization. This involves an ortho‐vinyl‐anilino‐amide as starting material which is converted to a keteniminium intermediate that spontaneously cyclize to form a 7‐membered ring iminium. Under slightly basic hydrolysis conditions, this latter is ultimately converted to the desired benzazepinone. Control experiments on the electron density of the nitrogen constituting the aniline were performed to support our proposed mechanism and rationalize the selectivity of the reaction.
An evaluation of the effects of general practitioner–supported patient noncommunicable diseases control model in Shanghai, China
Authors: Shu Zhiqun , Wang Ling , Sun Xiaoming 
Published: July 2019

SummaryNoncommunicable diseases (NCDs) are the leading cause of death worldwide. A litmus test for China's health reform is its ability to effectively deal with NCDs. The general practitioners (GPs)–supported NCD control model was designed to address ways to effectively prevent and control NCDs population‐wide. This study aimed to evaluate the GPs‐supported NCD control model and its effect on China's NCD control. The model was structured with three layers of two‐way relationships between patients, GPs, and specialists. The four technologies included the community‐based NCD self‐management model, the electronic clinical‐pathways–supporting community NCD intervention, the largest regional independent medical information system engaged by the Shanghai Healthcare Cloud, and continuous and successive policy intervention. Under the influence of the model, hypertension awareness, treatment, and control were the highest in Shanghai. By 31 August 2017, 131 453 users declined to use the mobile application while 10 444 completed the type 2 diabetes mellitus (T2DM) risk assessment. By 15 August 2017, 249 000 residents had participated in early detection and screening, leading to the identification of 29 304 (11.8%) being in a prediabetic state and 24 422 (9.8%) being newly diagnosed with T2DM. From 2012 to 2016, 208 537 patients were newly identified with hypertension using Internet‐connected devices and hypertension awareness increased 5.7%. After implementing the self‐management interventions, patients' blood pressure was controlled at around 90% (from 2007 to 2015). This pilot model in Shanghai suggested positive social benefits and appears to have played an important role in advancing NCD control in China.
Effects of prematurity on infants' joint attention abilities: A meta‐analytic study
Authors: Mateus Vera , Osório Ana , Martins Carla 
Published: July 2019

AbstractJoint attention abilities seem to be compromised in preterm infants. This meta‐analysis aimed at investigating whether premature infants differ systematically from full‐term infants in several dimensions of joint attention—initiating joint attention, responding to joint attention, and joint attention episodes—and explore whether such differences are dependent on gestational age. Bibliographic databases and repositories of dissertations and theses were searched from January 1970 to June 2016. Empirical studies were eligible if an observational measure was used to assess joint attention from 9‐ to 24‐month corrected age and a full‐term comparison group was included. Overall, preterm infants did not differ from full‐term infants across each joint attention dimension. However, impairments emerged for responding and joint attention episodes when degree of prematurity was considered. Results suggest that distinct dimensions of joint attention may be differently influenced by prematurity.Highlights

Meta‐analysis aimed at investigating the effect of prematurity on infants' joint attention abilities.
Overall, preterm and full‐term infants did not differ in joint attention, but specific impairments emerged when considering degree of prematurity.
Results suggest a differential impact of prematurity on specific dimensions of infants' joint attention abilities.
Chromatin nanoscale compaction in live cells visualized by acceptor‐to‐donor ratio corrected Förster resonance energy transfer between DNA dyes
Authors: Pelicci Simone , Diaspro Alberto , Lanzanò Luca 
Published: July 2019

Abstract@Chromatin nanoscale architecture in live cells can be studied by Förster resonance energy transfer (FRET) between fluorescently labeled chromatin components, such as histones. A higher degree of nanoscale compaction is detected as a higher FRET level, since this corresponds to a higher degree of proximity between donor and acceptor molecules. However, in such a system, the stoichiometry of the donors and acceptors engaged in the FRET process is not well defined and, in principle, FRET variations could be caused by variations in the acceptor‐to‐donor ratio rather than distance. Here, to get a FRET level independent of the acceptor‐to‐donor ratio, we combine fluorescence lifetime imaging detection of FRET with a normalization of the FRET level to a pixel‐wise estimation of the acceptor‐to‐donor ratio. We use this method to study FRET between two DNA binding dyes staining the nuclei of live cells. We show that this acceptor‐to‐donor ratio corrected FRET imaging reveals variations of nanoscale compaction in different chromatin environments. As an application, we monitor the rearrangement of chromatin in response to laser‐induced microirradiation and reveal that DNA is rapidly decompacted, at the nanoscale, in response to DNA damage induction.
Increased Risk of Bone Fractures in Hemodialysis Patients Treated with Proton Pump Inhibitors in Real World: Results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)
Authors: Fusaro Maria , D'Arrigo Graziella , Pitino Annalisa , Iervasi Giorgio , Tentori Francesca , Robinson Bruce , Aghi Andrea , Bieber Brian , Mccullogh Keith , Fabris Fabrizio , Plebani Mario , Giannini Sandro , Gallieni Maurizio , Tripepi Giovanni 
Published: July 2019

ABSTRACT
Long-term treatment with proton pump inhibitors (PPIs) is associated with an increased risk of fractures in the general population. PPIs are widely prescribed to dialysis patients but to date no study has specifically tested, by state-of-art statistical methods, the relationship between use of PPIs and fractures in this patient population. This study aimed to assess whether use of PPIs is associated with bone fractures (ie, hip fractures and fractures other than hip fractures) in a large international cohort of hemodialysis patients. We considered an observational prospective cohort of 27,097 hemodialysis patients from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Data analysis was performed by the Fine and Gray method, considering the competitive risk of mortality, as well as by a cause-specific hazards Cox model with death as a censoring event and matching patients according to the prescription time. Of 27,097 hemodialysis patients, 13,283 patients (49%) were on PPI treatment. Across the follow-up period (median, 19 months), 3.8 bone fractures × 100 person-years and 1.2 hip fractures × 100 person-years occurred. In multiple Cox models, considering the competitive risk of mortality, the incidence rate of bone (subdistribution hazard ratio [SHR] 1.22; 95% CI, 1.10 to 1.36; p &lt; 0.001) and hip fractures (SHR 1.35; 95% CI, 1.13 to 1.62; p = 0.001) was significantly higher in PPI-treated than in PPI-untreated patients. These findings also held true in multiple, cause-specific, hazards Cox models matching patients according to the prescription time (bone fractures: HR 1.47; 95% CI, 1.23 to 1.76; p &lt; 0.001; hip fractures: HR 1.85; 95% CI, 1.37 to 2.50; p &lt; 0.001). The use of PPIs requires caution and a careful evaluation of risks/benefits ratio in hemodialysis patients. © 2019 American Society for Bone and Mineral Research.
Neonicotinoid pesticides poorly interact with human drug transporters
Authors: Le Vée Marc , Bacle Astrid , Bruyere Arnaud , Fardel Olivier 
Published: July 2019

AbstractThe interactions of six neonicotinoid pesticides and one neonicotinoid metabolite with drug transporters have been characterized in vitro. Acetamiprid, clothianidin, imidacloprid, nitenpyram, thiacloprid and its metabolite thiacloprid amide, and thiamethoxam, each used at 100 µM, did not impair activity of the efflux pumps P‐glycoprotein, multidrug resistance‐associated proteins, and breast cancer resistance protein. They also did not inhibit that of the uptake transporters OATP1B1, OATP1B3, OAT4, and MATE1, whereas that of OATP2B1, OAT1, and MATE2‐K was affected by only one of the seven neonicotinoids. Activity of OCT1 was moderately stimulated (up to 1.5‐fold) by several neonicotinoids. By contrast, that of OAT3 and OCT2 was inhibited by most (OAT3), if not all (OCT2), neonicotinoids, with IC50 values in the 20 to 60 µM range for thiacloprid, likely not relevant to environmental exposure. Thiacloprid was moreover not transported by OAT3 and OCT2. Overall, these data suggest that neonicotinoid pesticides rather poorly interact with drug transporter activities.
The role of microRNAs in the regulation of insulin signaling pathway with respect to metabolic and mitogenic cascades: A review
Authors: Ebrahimi Reyhane , Bahiraee Alireza , Niazpour Farshad , Emamgholipour Solaleh , Meshkani Reza 
Published: July 2019

AbstractInsulin resistance (IR) is a shared pathological condition among type 2 diabetes, obesity, cardiovascular disease, and other metabolic disorders. It is growing significantly all over the world and consequently, a substantial effort is needed for developing the potential novel diagnostics and therapeutics. An insulin signaling pathway is tightly modulated by different mechanisms including the epigenetic modifications. Today, a deal of great attention has been shifted towards the regulatory role of noncoding RNAs on target proteins of the insulin signaling pathway. Noncoding RNAs are a major area of the epigenetics which control gene expression at the posttranscriptional levels and include a large class of microRNAs (miRNAs). With this in view, many studies have implicated the mediatory effects of miRNAs on the downstream metabolic and mitogenic proteins of the insulin signaling pathway. Since providing new biomarkers for the early diagnosis of IR and related metabolic traits are very significant, we intended to review the possible role of miRNAs in the regulation of the insulin signaling pathway, with a primary focus on the downstream target proteins of the metabolic and mitogenic cascades.
Immobilization of HIV‐1 TAT peptide on gold nanoparticles: A feasible approach for siRNA delivery
Authors: Ahwazi Razieh P. , Kiani Melika , Dinarvand Meshkat , Assali Akram , Tekie Farnaz S. M. , Dinarvand Rasoul , Atyabi  Fatemeh 
Published: July 2019

AbstractRNA interference is one of the prosperous approaches for cancer treatment. However, small interfering RNA (siRNA) delivery to cancer cells has been faced with various challenges restricting their clinical application over the decades. Since ROR1 is an onco‐embryonic gene overexpressed in many malignancies, suppression of ROR1 by siRNA can potentially fight cancer. Herein, a delivery system for ROR1 siRNA based on HIV‐1 TAT peptide‐capped gold nanoparticles (GNPs) was developed to treat breast cancer. Besides, we introduced a new feasible method for conjugating the peptide to the nanoparticles. Since the GNPs have high affinity to the sulfur, the findings demonstrated the peptide successfully conjugated to the nanoparticles via Au–S bonds. As positively charged nanoparticles showed high cellular uptake, we could use a low concentration of nanoparticles led to high efficient gene transfection with negligible cytotoxicity that was confirmed by flow cytometry, confocal microscopy, gel retardation, and 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay. Following transfection, downregulation of ROR1 and its targeted gene, CCND1, induced apoptosis in cancer cells. In conclusion, the reported capped GNPs could be potentially utilized for delivering negatively charged therapeutic agents in particular genes.
Subclavicular flap: A valid reconstructive option among anterior chest flaps in oral cancer patients
Authors: Mannelli Giuditta , Agostini Tommaso , Arcuri Francesco , Comini Lara Valentina , Spinelli Giuseppe 
Published: July 2019

AbstractBackgroundThe subclavicular pedicled flap is based on the thoracic branch of the supraclavicular artery, and it represents a versatile reconstructive option for low‐middle third face defects. Since its use in head and neck surgical oncology has not been popularized yet, we propose its application for oral cavity reconstruction after cancer resection by showing favorable results.MethodsEighteen subclavicular pedicled flaps were used to treat intraoral defects after oral squamous‐cell cancer resection between June 2015 and December 2018. Tumor dissection type, complications, donor and reconstructed area results, and functional and aesthetic outcomes were assessed.ResultsNo major complications were observed and all of the flaps survived. Adjuvant therapy was administered without delay when needed, and all of the patients had normal functional outcomes and good aesthetic results.ConclusionsThe subclavicular flap is an excellent choice for the reconstruction of oral cavity defects. Selection of patients should exclude positive lower‐third neck node and include appropriate informed consent for women due to the possibility of deformity of the breast. In our opinion, this flap has the potential for common application given its consistent anatomy and donor site advantages, including long pedicle, high pivot point, and relatively unlimited flap width.
Pre‐Vulcanization of Large and Small Natural Rubber Latex Particles: Film‐Forming Behavior and Mechanical Properties
Authors: Sriring Manus , Nimpaiboon Adun , Dechnarong Nattanee , Kumarn Sirirat , Higaki Yuji , Kojio Ken , Takahara Atsushi , Ho Chee Cheong , Sakdapipanich Jitladda 
Published: July 2019

AbstractThe pre‐vulcanized large rubber particle (LRP) and small rubber particle (SRP) latices are independently prepared to investigate their film‐forming process and mechanical properties after being cast into films. The surface morphologies and roughness of both LRP and SRP films are found to be dependent on crosslink densities. The networks inside each rubber particle (RP) restrict particle deformation resulting in residual contour of RP within the film surface. For highly crosslinked RP, the collapse of the top surface of the RPs in the LRP films appears to create many “crater‐like” structures within the film surfaces, while they present only protruding particles within the SRP and blend films. This seems to indicate that LRPs are easier to coalesce and form film than SRPs. Additionally, dynamic and mechanical properties and strain‐induced crystallization (SIC) behaviors of the latex films, are effectively enhanced after pre‐vulcanization. The pre‐vulcanized LRP films perform better tensile properties and SIC than the SRP can.
Stepwise Optimized 3D Printing of Arbitrary 3D Structures at Millimeter Scale with High Precision Surface
Authors: Yang Hua , Zhao Yuan‐Yuan , Zheng Mei‐Ling , Jin Feng , Dong Xian‐Zi , Duan Xuan‐Ming , Zhao Zhen‐Sheng 
Published: July 2019

Abstract3D printing based on additive manufacturing has attracted widespread attention in the fields of microbiology and microelectronics due to its advantages of waste reduction, arbitrary manufacturing, and rapid prototyping in potential applications. These techniques can create structures at the centimeter scale, however, there are some limitations in terms of resolution and geometric constraints. Here, a micro–nano 3D printing protocol based on additive manufacturing to achieve the 3D structure (3DS) not only possessing millimeter scale structural dimensions but also nanometer features are proposed. A theory is verified to assist the design and fabrication of the 3DS with millimeter scale and nanometer precision. The structures are predesigned and the scanning strategy is optimized before 3D printing to improve the manufacturing efficiency and precision. A customized 3DS with a height of 2.2 mm is obtained, which is a challenge for the conventional two‐photon polymerization fabrication. Furthermore, a 1.2 mm 3DS with inside scaffold and smooth surface is efficiently achieved within 2.7 h with a nanometer surface roughness by using the proposed stepwise optimized 3D printing process. This study offers a flexible and low‐cost technology to generate highly customizable, precisely controllable 3DS for potential applications in microelectronics and microdevices.
Activation of cryptic splice sites in three patients with chronic granulomatous disease
Authors: de Boer Martin , van Leeuwen Karin , Hauri‐Hohl Mathias , Roos Dirk 
Published: July 2019

AbstractBackgroundChronic granulomatous disease (CGD) is a primary immune deficiency caused by mutations in the genes encoding the structural components of the phagocyte NADPH oxidase. As a result, the patients cannot generate sufficient amounts of reactive oxygen species required for killing pathogenic microorganisms.MethodsWe analyzed NADPH oxidase activity and component expression in neutrophils, performed genomic DNA and cDNA analysis, and used mRNA splicing prediction tools to evaluate the impact of mutations.ResultsIn two patients with CGD, we had previously found mutations that cause aberrant pre‐mRNA splicing. In one patient an exonic mutation in a cryptic donor splice site caused the deletion of the 3' part of exon 6 from the mRNA of CYBB. This patient suffers from X‐linked CGD. The second patient, with autosomal CGD, has a mutation in the donor splice site of intron 1 of CYBA that activates a cryptic donor splice site downstream in intron 1, causing the insertion of intronic sequences in the mRNA. The third patient, recently analyzed, also with autosomal CGD, has a mutation in intron 4 of CYBA, 15 bp from the acceptor splice site. This mutation weakens a branch site and activates a cryptic acceptor splice site, causing the insertion of 14 intronic nucleotides into the mRNA.ConclusionWe found three different mutations, one exonic, one in a donor splice site and one intronic, that all caused missplicing of pre‐mRNA. We analyzed these mutations with four different splice prediction programs and found that predictions of splice site strength, splice enhancer and splice silencer protein binding and branch site strength are all essential for correct prediction of pre‐mRNA splicing.