bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of biclustering algorithm to extract rules from labeled data
Authors: Yanjie Zhang , Hongbo Sun 
Published: June 2018

Purpose
For many pattern recognition problems, the relation between the sample vectors and the class labels are known during the data acquisition procedure. However, how to find the useful rules or knowledge hidden in the data is very important and challengeable. Rule extraction methods are very useful in mining the important and heuristic knowledge hidden in the original high-dimensional data. It can help us to construct predictive models with few attributes of the data so as to provide valuable model interpretability and less training times.

Design/methodology/approach
In this paper, a novel rule extraction method with the application of biclustering algorithm is proposed.

Findings
To choose the most significant biclusters from the huge number of detected biclusters, a specially modified information entropy calculation method is also provided. It will be shown that all of the important knowledge is in practice hidden in these biclusters.

Originality/value
The novelty of the new method lies in the detected biclusters can be conveniently translated into if-then rules. It provides an intuitively explainable and comprehensive approach to extract rules from high-dimensional data while keeping high classification accuracy.
The mediating effects of social entrepreneurial antecedents on the relationship between prior experience and social entrepreneurial intent
Authors: Lacap Jean Paolo G. , Mulyaningsih Hendrati Dwi , Ramadani Veland 
Published: June 2018

Purpose
The paper aims to investigate how the social entrepreneurial intention antecedents directly and indirectly affect social entrepreneurial intent. The participants of the study were Filipino and Indonesian university students from selected higher education institutions (HEIs).

Design/methodology/approach
A quantitative research design was used and partial least square-structural equation modeling was used to measure the direct and indirect effects of the structural model.

Findings
The results revealed that prior experience with social problems positively and significantly affects empathy, moral obligation, social entrepreneurial self-efficacy and perceived social support. Moreover, it was also found that social entrepreneurial self-efficacy and perceived social support positively and significantly affect social entrepreneurial intent, and these two antecedents mediate the positive relationship between prior experience with social problems and social entrepreneurial intent.

Research limitations/implications
As the present study only examined social entrepreneurial intentions among Filipino and Indonesian university students, other researchers may test the framework in another locale. Others may find interest in identifying the significant difference in social entrepreneurial intent among between or among nations.

Practical implications
The findings of the present study can benefit HEIs in terms of offering social entrepreneurship programs and courses. The role of HEIs is truly important. Providing an avenue for students for them to be socially entrepreneurial and empowering them to be future social entrepreneurs can truly help in sustainably promoting social entrepreneurship. These can be done by designing relevant learning materials and requirements that will permit students to be social venture creators.

Social implications
Based on this study, if these students were exposed to social entrepreneurship activities during their university life (prior experience), then the propensity for them to be social venture creators in high. With the myriad problems in the Philippines and Indonesia, exposure to social problems is evident. Through proper inculcation of social entrepreneurial spirit, Filipino and Indonesian students will greatly create massive impact in the landscape of Asian social entrepreneurship.

Originality/value
The present study offers a new perspective on social entrepreneurial intentions, as it is in Asian setting. It also provides a viewpoint where only social entrepreneurial self-efficacy and perceived social support positively affect social entrepreneurial intent and, at the same time, act as mediators between prior experience with social problem and social entrepreneurial intent. With these results, it enriches the theoretical foundations of social entrepreneurship.
Why is dialogue on performance challenging in the public sector?
Authors: Rajala Tomi , Laihonen Harri , Haapala Petra 
Published: June 2018

PurposeThis paper aims to understand performance management as a social phenomenon by investigating the challenges of performance dialogue, a phenomenon where participants jointly interpret performance information and discuss it while identifying the actions needed to manage the performance according to this information.Design/methodology/approachThe research aim is achieved by conducting an interview study. Empirical data were collected by interviewing 30 public managers in three Finnish municipalities and subjecting it to content analysis using inductive category development.FindingsThe research provides empirical evidence from challenges in engaging in performance dialogue. It moreover derives a comprehensive conceptual model categorizing factors inhibiting performance dialogue.Practical implicationsDifficulties in conducting organizational performance dialogues are better explained. The findings support the management of performance dialogue by helping practitioners to identify challenges associated to these dialogues.Originality/valueThis study contributes to current conversations on performance management by showing that performance dialogues are no miracle cure for problems in performance information use. Moreover, the authors demonstrate that complications in performance information use are intertwined in many ways.
Aligning purchasing portfolio management with sourcing negotiation styles
Authors: Kang Mingu , Hong Paul , Bartnik Roman , Park Youngwon , Ko Changsuk 
Published: June 2018

PurposeThe purpose of this paper is to examine how to align purchasing portfolio management with sourcing negotiation styles.Design/methodology/approachThe authors have adopted two-step field tests: a case study; and a follow-up experimental test with 77 sourcing professionals.FindingsThe authors note that Kraljic Portfolio Matrix (KPM) provides a valuable guide for determining sourcing negotiation styles (i.e. competitive negotiation for leverage items, collaborative negotiation for strategic items and accommodative negotiation for bottleneck items). Interestingly, effective buyers adopt right negotiation styles based on the switching costs of changing suppliers, the dependence level on specific suppliers and the availability of alternative suppliers.Originality/valueThis study shows that aligning purchasing portfolio management with sourcing negotiation styles improves the chances of effective buying outcomes. Practical implications suggest that successful buyers move beyond interpreting generic predictions of the KPM framework and rather implement specific negotiation styles to maximize the potential benefits of purchasing portfolio management.
The South African chartered accountant academic
Authors: de Jager Phillip , Lubbe Ilse , Papageorgiou Elmarie 
Published: June 2018

PurposeAccounting academics in the South African system understand their primary responsibility to be the teaching of prospective Chartered Accountants (CAs) rather than the advancement of knowledge through research. The purpose of this study is to determine what factors motivate accounting academics who are CAs to obtain doctorates in an environment dominated by the profession, where promotion is possible to Full Professor without a Doctorate but not without the professional qualification of CA. And did these doctoral CAs face challenges on their journey, such as resistance from colleagues?Design/methodology/approachA total of 22 academic CAs with doctorates and 18 academic CAs studying towards doctorates were surveyed to gain a deeper understanding of who they are, what their motivations were for undertaking the doctorate journey and what they experienced.FindingsThe main finding of this study is that the culture of accounting departments in South Africa is beginning to shift from being teaching orientated towards being more research orientated. The CAs are pursuing doctorates for the purpose of career progression and for intrinsic personal reasons. The main challenges that they faced on their journey were finding the time for family and a social life and a lack of support from colleagues and their institution. However, support seems to be improving.Research limitations/implicationsThe change to a research-orientated culture in South African departments of accounting, as envisioned by Van der Schyf (2008), is only now starting to take place. These CAs with doctorates provide evidence of that change.Originality/valueThe value of this study is to provide accounting academics and the profession with a better understanding of, and a greater sensitivity to, accounting academics operating under the influence of the South African Institute of Chartered Accountants (SAICA). The study also adds to the limited amount of literature on the motives and experiences of doctoral students, especially accounting doctoral students.
Types of professionalization
Authors: Lang Grazia , Schlesinger Torsten , Lamprecht Markus , Ruoranen Kaisa , Klenk Christoffer , Bayle Emmanuel , Clausen Josephine , Giauque David , Nagel Siegfried 
Published: June 2018

Purpose
The purpose of this paper is to identify types of professionalization in Swiss national sport federations (NSFs) and analyze organizational characteristics associated with specific types of professionalization. Such types reveal common patterns among the increasingly complex organizational designs of NSFs and thus contribute to the understanding of professionalization in NSFs.

Design/methodology/approach
An online survey of all Swiss NSFs was conducted to identify types of professionalization in these organizations using hierarchical cluster analysis, based on a multi-dimensional framework of professionalization.

Findings
The analysis revealed four types of professionalization: formalized NSFs managed by paid staff, NSFs managed by volunteers and a few paid staff off the field, NSFs with differing formalization and paid staff on the field, and moderately formalized NSFs managed by volunteers. The types differ in terms of the NSFs’ organizational characteristics, in particular, size, financial resources, Olympic status, and performance.

Originality/value
Applying factor and cluster analysis is a new approach to analyzing professionalization in NSFs that makes uncovering distinctive organizational patterns among a large number of NSFs possible. These results lay the foundation for understanding the professionalization of NSFs, counseling NSFs on their organizational development, and conducting future research on the design types of sport organizations.
Why Britain Needs a Written Constitution—and Can't Wait for Parliament to Write One
Authors: Ackerman Bruce 
Published: June 2018

AbstractThe lecture explores basic constitutional choices confronting post‐Brexit Britain, emphasising dilemmas generated by Irish, Scottish, and Welsh demands for home rule. It argues that only a specially elected Constitutional Convention, independent of Parliament, has the capacity and legitimacy to hammer out a written constitution that tries to resolve these dilemmas in a serious way. Once the Convention acts, its proposal should be submitted for approval at a referendum, but only after special steps are taken to encourage an informed decision by the electorate. Given the misinformation campaigns provoked by the last referendum, it is time for Britain to try something new: create a new national holiday, Deliberation Day, at which voters would be invited to gather at neighbourhood community centres to discuss the Convention's initiative. A host of social science experiments establish that a day's deliberation greatly improves public understanding, enhancing the democratic authority of a Yes vote at the referendum.
This Time it's Different: Legitimacy and the Limits of Differentiation after Brexit
Authors: Glencross Andrew 
Published: June 2018

AbstractBritish political debate since the EU referendum has hinged on what type of Brexit to pursue: hard or soft. Yet, unlike in instances of treaty rejection, the EU made no counter offer to avoid a breakdown in relations that would follow the hardest of exits. This remarkable unity in not discounting the possibility of a hard Brexit demonstrates that UK withdrawal is very distinct from previous wrangles over EU reform. Drawing on the work of Kissinger, this article argues Brexit is a revolutionary act that denies the legitimacy of the EU order. Hence this process does not conform to other episodes of differentiation. When Westminster sought opt‐outs, it did not reject the core principles of integration. By not seeking to oppose a hard Brexit, Brussels has forced the UK government to find a new legitimising principle to govern EU–UK relations, transferring the burden of adjustment to London.
Perinatal outcomes after open fetal surgery for myelomeningocele repair: a retrospective cohort study
Authors: Moron AF , Barbosa MM , Milani HJF , Sarmento SG , Santana EFM , Suriano IC , Dastoli PA , Cavalheiro S 
Published: June 2018

ObjectiveDescribe outcomes of open fetal surgery for myelomeningocele (MMC) repair in two Brazilian hospitals and the impact of surgical experience on outcome.DesignRetrospective cohort study.SettingSao Paulo, Brazil.Population237 pregnant women carrying a fetus with an open spinal defect.MethodsSurgical details, and maternal and fetal outcomes collected from all patients.Main outcome measuresAnalysis of surgical and perinatal outcome parameters.ResultsTotal surgical time was 119 ± 7.6 minutes. Preterm labour occurred in 24.2%, premature rupture of membranes in 26.7%, placental abruption in 0.8%, need for a blood transfusion at delivery in 2.1%, and dehiscence at the repair site in 2.5%. Reversal of hindbrain herniation at birth occurred in 71.4%. There were no maternal deaths or severe maternal morbidities. The failure rate with the patient anaesthetised was 0.42% and perinatal mortality was 2.1% (three intrauterine demises and two neonatal deaths). Comparing results from our study in the first 3 years with the last 3 years demonstrated improvement in the total surgical time (121.2 ± 6.4 versus 118.5 ± 8.2 minutes, P = 0.005) and an increase in reversal of hindbrain herniation at birth (64.0 versus 77.1%, P = 0.042).ConclusionOur open fetal surgical approach for MMC was effective and results were comparable to past studies. Improvements in surgical performance and perinatal outcome increased as the surgical team became more familiar with the procedure.FundingThe study was funded solely by institutional funds.Tweetable abstractBrazilian experience of in utero open surgery for myelomeningocele repair.
Is there benefit to continue magnesium sulphate postpartum in women receiving magnesium sulphate before delivery? A randomised controlled study
Authors: Vigil‐DeGracia P , Ludmir J , Ng J , Reyes‐Tejada O , Nova C , Beltré A , Yuen‐Chon V , Collantes J , Turcios E , Lewis R , Cabrera S 
Published: June 2018

ObjectiveTo determine if the use of magnesium sulphate postdelivery reduces the risk of eclampsia in women with severe pre‐eclampsia exposed to at least 8 hours of magnesium sulphate before delivery.DesignRandomised multicentre controlled trial.SettingLatin America.PopulationWomen with severe pre‐eclampsia that had received a 4‐g loading dose followed by 1 g per hour for 8 hours as maintenance dose before delivery.MethodsIn all, 1113 women were randomised; 555 women were randomised to continue the infusion of magnesium sulphate for 24 hours postpartum and 558 were randomised to stopping the magnesium sulphate infusion immediately after delivery.Outcome measuresPrimary outcome was the incidence of eclampsia in the first 24 hours postdelivery. Secondary outcomes included maternal death, maternal complications, time to start ambulation and time to start lactation.ResultsThe maternal characteristics at randomisation between the groups were not different. There were no differences in the rate of eclampsia; 1/555 (0.18%) versus 2/558 (0.35%) [relative risk (RR 0.7, 95% CI 0.1–3.3; P = 0.50] or maternal complications between the groups (RR 1.0, 95% CI 0.8–1.2; P = 0.76). Time to start ambulation was significantly shorter in the no magnesium sulphate group (18.1 ± 10.6 versus 11.8 ± 10.8 hours; P = 0.0001) and time to start lactation was equally shorter in the no magnesium sulphate group (24.1 ± 17.1 versus 17.1 ± 16.8 hours; P = 0.0001).ConclusionsWomen with severe pre‐eclampsia treated with a minimum of 8 hours of magnesium sulphate before delivery do not benefit from continuing the magnesium sulphate for 24 hours postpartum.Tweetable abstractNo benefit of continuing magnesium sulphate postpartum in severe pre‐eclampsia exposed to this drug for a minimum of 8 hours before delivery.
Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease
Authors: Baglietto‐Vargas David , Prieto Gilberto Aleph , Limon Agenor , Forner Stefania , Rodriguez‐Ortiz Carlos J. , Ikemura Kenji , Ager Rahasson R. , Medeiros Rodrigo , Trujillo‐Estrada Laura , Martini Alessandra C. , Kitazawa Masashi , Davila Jose C. , Cotman Carl W. , Gutierrez Antonia , LaFerla Frank M. 
Published: June 2018

SummaryAlzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, although the molecular and cellular mechanisms underlying these defects remain to be elucidated. Determining the timing and nature of the early synaptic deficits is critical for understanding the progression of the disease and for identifying effective targets for therapeutic intervention. Using single‐synapse functional and morphological analyses, we find that AMPA signaling, which mediates fast glutamatergic synaptic transmission in the central nervous system (CNS), is compromised early in the disease course in an AD mouse model. The decline in AMPA signaling is associated with changes in actin cytoskeleton integrity, which alters the number and the structure of dendritic spines. AMPA dysfunction and spine alteration correlate with the presence of soluble but not insoluble Aβ and tau species. In particular, we demonstrate that these synaptic impairments can be mitigated by Aβ immunotherapy. Together, our data suggest that alterations in AMPA signaling and cytoskeletal processes occur early in AD. Most important, these deficits are prevented by Aβ immunotherapy, suggesting that existing therapies, if administered earlier, could confer functional benefits.
A systematic literature review of the human skin microbiome as biomarker for dermatological drug development
Authors: Niemeyer ‐ van der Kolk T. , van der Wall H. E. C. , Balmforth C. , Van Doorn M. B. A. , Rissmann R. 
Published: June 2018

AimsTo explore the potential of the skin microbiome as biomarker in six dermatological conditions: atopic dermatitis (AD), acne vulgaris (AV), psoriasis vulgaris (PV), hidradenitis suppurativa (HS), seborrhoeic dermatitis/pityriasis capitis (SD/PC) and ulcus cruris (UC).MethodsA systematic literature review was conducted according to the PRISMA guidelines. Two investigators independently reviewed the included studies and ranked the suitability microbiome implementation for early phase clinical studies in an adapted GRADE method.ResultsIn total, 841 papers were identified and after screening of titles and abstracts for eligibility we identified 42 manuscripts that could be included in the review. Eleven studies were included for AD, five for AV, 10 for PV, two for HS, four for SD and 10 for UC. For AD and AV, multiple studies report the relationship between the skin microbiome, disease severity and clinical response to treatment. This is currently lacking for the remaining conditions.ConclusionFor two indications – AD and AV – there is preliminary evidence to support implementation of the skin microbiome as biomarkers in early phase clinical trials. For PV, UC, SD and HS there is insufficient evidence from the literature. More microbiome‐directed prospective studies studying the effect of current treatments on the microbiome with special attention for patient meta‐data, sampling methods and analysis methods are needed to draw more substantial conclusions.
Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery
Authors: Coussens Nathan P. , Sittampalam G. Sitta , Guha Rajarshi , Brimacombe Kyle , Grossman Abigail , Chung Thomas D. Y. , Weidner Jeffrey R. , Riss Terry , Trask O. Joseph , Auld Douglas , Dahlin Jayme L. , Devanaryan Viswanath , Foley Timothy L. , McGee James , Kahl Steven D. , Kales Stephen C. , Arkin Michelle , Baell Jonathan , Bejcek Bruce , Gal‐Edd Neely , Glicksman Marcie , Haas Joseph V. , Iversen Philip W. , Hoeppner Marilu , Lathrop Stacy , Sayers Eric , Liu Hanguan , Trawick Bart , McVey Julie , Lemmon Vance P. , Li Zhuyin , McManus Owen , Minor Lisa , Napper Andrew , Wildey Mary Jo , Pacifici Robert , Chin William W. , Xia Menghang , Xu Xin , Lal‐Nag Madhu , Hall Matthew D. , Michael Sam , Inglese James , Simeonov Anton , Austin Christopher P. 
Published: June 2018

AbstractThe Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.
Factors associated with a positive willingness to practise oral health care in the future amongst oral healthcare and nursing students
Authors: Haresaku S. , Monji M. , Miyoshi M. , Kubota K. , Kuroki M. , Aoki H. , Yoshida R. , Machishima K. , Makino M. , Naito T. 
Published: June 2018

AbstractObjectivesThe purpose of this study was to identify the weak points in the knowledge and attitudes of first‐year oral health care and nursing students towards oral health care and to identify the factors associated with their positive willingness to practise oral health care after becoming a health professional in order to develop oral healthcare curricula.Materials and methodsThe subjects were 88 first‐year dental students (DSs), 64 dental hygiene students (DHSs) and 119 nursing students (NSs) enrolled in schools in Japan, as of April 2017. A questionnaire was distributed to subjects in each school to assess their knowledge and attitudes towards oral health care.ResultsLess than half knew that oral health care was also provided in cancer hospitals, hospices, acute care hospitals, maternity wards and psychiatric wards. Only 46.2% knew that oral health care was effective in the prevention of aspiration pneumonia. The level of knowledge and attitudes in NSs regarding oral health care were likely to be lowest amongst the student groups. Only NSs' high interest towards oral health care was associated with their positive willingness to practise oral health care in the future although oral health students' high perceptions and interest regarding oral health care were associated with the willingness.ConclusionThis study showed oral healthcare and nursing students' weak points regarding their attitudes and knowledge of oral health care at early stages. Oral health academic staff and professionals should develop effective oral healthcare curricula for oral healthcare students and help nursing staff develop a collaborative nursing oral healthcare curriculum to motivate nursing students.