bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multilingualism impacts children's executive function and core autism symptoms
Authors: Romero Celia , Goodman Zachary T. , Kupis Lauren , Dirks Bryce , Parlade Meaghan V. , Beaumont Amy L. , Cardona Sandra M. , Nomi Jason S. , Alessandri Michael , Perry Lynn K. , Uddin Lucina Q. 
Published: November 2024

AbstractAutism spectrum disorder (ASD) is associated with marked heterogeneity in executive function (EF) abilities. EF components including inhibition and shifting are related to ASD core symptoms such as perspective taking, social communication, and repetitive behavior. Recent research suggests that multilingualism may have a beneficial impact on EF abilities, especially in children with ASD. However, there remains a lack of comprehensive understanding regarding the relationships between multilingualism, EF, and core symptoms in children with ASD. Here, we examined these associations in 7–12‐year‐old children with and without ASD (N = 116; 53 ASD, Mean age = 9.94 years). Results suggest that multilingual children have stronger parent‐reported inhibition, shifting, and perspective‐taking skills than monolingual children. Furthermore, we found a significant interaction between diagnosis and multilingual status on inhibition, such that the effects of multilingualism were stronger for children with ASD than typically developing (TD) children. Finally, we found indirect effects of multilingualism on perspective taking, social communication, and repetitive behaviors mediated by EF skills. These results demonstrate the supportive influences multilingual experience might have on bolstering EF and reducing ASD‐related symptoms.
Mixture Cure Semiparametric Accelerated Failure Time Models With Partly Interval‐Censored Data
Authors: Li Isabel , Ma Jun , Liquet Benoit 
Published: November 2024

ABSTRACTIn practical survival analysis, the situation of no event for a patient can arise even after a long period of waiting time, which means a portion of the population may never experience the event of interest. Under this circumstance, one remedy is to adopt a mixture cure Cox model to analyze the survival data. However, if there clearly exhibits an acceleration (or deceleration) factor among their survival times, then an accelerated failure time (AFT) model will be preferred, leading to a mixture cure AFT model. In this paper, we consider a penalized likelihood method to estimate the mixture cure semiparametric AFT models, where the unknown baseline hazard is approximated using Gaussian basis functions. We allow partly interval‐censored survival data which can include event times and left‐, right‐, and interval‐censoring times. The penalty function helps to achieve a smooth estimate of the baseline hazard function. We will also provide asymptotic properties to the estimates so that inferences can be made on regression parameters and hazard‐related quantities. Simulation studies are conducted to evaluate the model performance, which includes a comparative study with an existing method from the smcure R package. The results show that our proposed penalized likelihood method has acceptable performance in general and produces less bias when faced with the identifiability issue compared to smcure. To illustrate the application of our method, a real case study involving melanoma recurrence is conducted and reported. Our model is implemented in our R package aftQnp which is available from https://github.com/Isabellee4555/aftQnP.
A novel, sensitive, and fast ultra‐high‐performance liquid chromatography tandem mass spectrometry method for TNG908 determination in dog plasma and pharmacokinetic study
Authors: Zhu Weiwei , Zhang Huiying , Li Fan 
Published: November 2024

AbstractTNG908 is a potent and selective protein arginase methyltransferase 5 (PRMT5) inhibitor that is currently going through phase I/II clinical development for the treatment of non‐small cell lung cancer. To facilitate pharmacokinetic and toxicokinetic studies of TNG908, here, we reported an ultra‐high‐performance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) method for the detection of TNG908 in dogs. The dog plasma samples were precipitated by acetonitrile and analyzed using a Waters ACQUITY BEH C18 column combined with a Thermo triple quadrupole mass spectrometer. The mobile phase consisted of 0.1% formic acid solution and acetonitrile, at a flow rate of 0.3 mL/min. TNG908 and internal standard were monitored by selective reaction monitoring (SRM) with m/z 410.2 > 150.1 and m/z 394.2 > 278.1, respectively. The method demonstrated excellent linearity over the concentration range of 1–1000 ng/mL, with a correlation coefficient greater than 0.995. Acetonitrile‐mediated protein precipitation showed high extraction efficiency and a recovery above 80%. The validated assay was further applied to measure TNG908 in dog plasma after oral and intravenous administration and achieved success. The obtained pharmacokinetic parameters indicated low clearance of TNG908 (3.7 ± 0.8 mL/min/kg) and moderate oral bioavailability (>36.4%).
Mechanical Thrombectomy for Treatment of Acute Cerebral Infarction due to Distal Medium Vessel Occlusions: A Retrospective Cohort Study
Authors: Zhang Lihong , Su Fanfan , Zhang Jianhui , Xu Jia , Zhao Manhong , Li Di , Yin Lin 
Published: November 2024

ABSTRACTBackgroundMechanical thrombectomy (MT) is standard of care for acute cerebral infarction (ACI) due to large vessel occlusions. However, its clinical efficacy in patients with ACI due to distal medium vessel occlusions (DMVOs) remains unclear. This study evaluates the efficacy and safety of MT in patients with ACI due to DMVOs.MethodsTotally, 306 patients with ACI at a very early stage were assigned into DMVOs‐MT, M1‐MT, and DMVOs‐intravenous thrombolysis (IVT) groups. These groups were compared regarding baseline data, recanalization rate, location of vessel occlusions, number of thrombectomy, first‐pass recanalization, mRS scores, NIHSS scores, 90‐day mRS scores, incidence of adverse events, and mortality. Risk factors for poor prognosis of patients with DMVOs following MT were analyzed.ResultsDMVOs‐MT and M1‐MT groups showed comparable first‐pass recanalization rates, recanalization rates, and NIHSS score reduction ratios, with marked differences in location of vessel occlusions. Versus DMVOs‐IVT, DMVOs‐MT had increased differences between pre‐ and post‐treatment NIHSS scores and between pre‐treatment NIHSS scores and NIHSS scores at discharge and elevated NIHSS reduction ratios. The poor prognosis rate of DMVOs‐MT group was insignificantly different from that of M1‐MT group but lower than that of DMVOs‐IVT group. Adverse events and mortality incidences were comparable among the three groups. Diabetes, first‐pass recanalization, and pre‐treatment NIHSS scores were independent risk factors for poor prognosis in DMVO patients after MT.ConclusionMT is as effective and safe in patients with DMVOs as in patients with M1 occlusions. In patients with DMVOs, MT has higher efficacy and safety than IVT.
Effect of Dual‐Site Non‐Invasive Brain Stimulation on Upper‐Limb Function After Stroke: A Systematic Review and Meta‐Analysis
Authors: Ren Meng , Xu Jingjing , Wang Wenjing , Shen Lexian , Wang Chaojie , Liu Haoyang , Chen Lu , Liu Chanjing , Tang Yongheng , Wang Jiening , Liu Tiantian 
Published: November 2024

ABSTRACTBackgroundNon‐invasive brain stimulation (NIBS) has attracted significant attention as it has been proven to be effective in facilitating upper limb motor recovery in patients with stroke. This meta‐analysis evaluates the efficacy of dual‐site non‐invasive brain stimulation (DS‐NIBS) in improving upper extremity motor function after stroke.MethodsA PRISMA systematic search was conducted for randomized controlled trials. Two authors independently extracted data, and the quality of included studies was assessed.ResultsTen studies were included in the current review. DS‐NIBS demonstrated a significant effect on upper extremity motor function impairment. However, only two studies showed no clear effects of DS‐tDCS on upper extremity motor function after stroke. Due to the limited number of studies, the effects of DS‐NIBS remain inconclusive.FindingThis review found evidence for the relatively higher efficacy of DS‐NIBS on post‐stroke upper extremity motor function impairment, compared to the sham and SS‐NIBS. Additionally, DS‐TMS was found to generate better improvement than DS‐tDCS.
Digitalization for circular economy and operational excellence practices: A paradox theory perspective on performance improvement in manufacturing firms
Authors: Prashar Anupama , Chaudhuri Atanu 
Published: November 2024

AbstractThe present study evaluates how the joint implementation of circular economy (CE) and operational excellence (OE) practices supported by the adoption of industry 4.0 technologies (Internet of Things and Big Data Analytics) influence manufacturing firms' operational performance and environmental sustainability. Drawing from the paradox theory, it also investigates the moderating role of managing paradoxical tensions arising from these implementations. To test the hypothesized relationships, survey data are collected from 147 Indian manufacturing firms implementing CE, OE practices, and internet of things (IoT) and big data analytics (BDA)‐enabled digital systems. The data are analyzed using structural equation modeling and moderated mediation analysis. Results indicate a direct significant effect of adoption of IoT and BDA‐enabled digital systems on operational performance and environmental sustainability, and partial mediation by CE and OE implementations, respectively. There is a strong moderation of managing paradoxical tensions on the impact of CE and OE implementations on performance. Additionally, the conditional indirect effect of CE implementations on the environmental sustainability outcomes of the IoT and BDA adoption increases with greater effort in managing paradoxical tensions. The study answers the call for empirical research on the organizational tensions that surface due to conflicting demands of initiatives related to operational efficiency and environmental sustainability.
In Silico and In Vitro Evaluation of Quinoline Derivatives as Potential Inhibitors of AChE, BACE1, and GSK3β for Neurodegenerative Diseases Treatment
Authors: Assis de Oliveira Bruno , Gonçalves de Oliveira Filipe , de Assis Cruz Otávio , Mendonça de Assis Pollyana , Glanzmann Nícolas , David da Silva Adilson , Rezende Barbosa Raposo Nádia , Zabala Capriles Goliatt Priscila Vanessa 
Published: November 2024

AbstractNeurodegenerative diseases are characterized by the structural and functional loss of neurons, which impacts populations worldwide. Enzymes such as acetylcholinesterase (AChE), beta‐site APP cleaving enzyme‐1 (BACE1), and glycogen synthase kinase 3‐beta (GSK3β) are implicated in their progression. Therefore, developing compounds that inhibit these enzymes is relevant for treating these conditions. This study investigated the potential of quinoline analogs as multitarget enzyme inhibitors through in silico and in vitro assays. In silico analyses highlighted one of the derivatives as the most potent inhibitor for all proteins. In vitro assays confirmed that the quinoline derivatives modulated the activity of the three targets. The best derivative in silico also exhibited significant AChE inhibition of 94.6 %. For GSK3β and BACE1, four derivatives, with quinoline linked to the sulfonamide nitrogen, showed inhibition values above 40 %. Two of them demonstrated no cytotoxicity for human glioblastoma cell proliferation, and the most potent was noncytotoxic at 7.8 and 3.9 μg mL−1. In murine fibroblasts, the most potent derivative showed no cytotoxicity, unlike its effect on glioblastoma cells. Similarly, other derivatives were noncytotoxic at concentrations less than 62.5 μg mL−1. These findings highlight one of the derivatives as promising multitarget enzyme inhibitors for the treatment of neurodegenerative diseases.
Exploring the Remarkable Potential of Algal Biomass for the Production of Nutraceutical Compounds and Their Applications
Authors: Islam Muhammad , Ahmad Irfan , Shakir Hafiz Abdullah , Khan Muhammad , Franco Marcelo , Irfan Muhammad 
Published: November 2024

AbstractThe world population is expected to increase up to 9.6 billion by 2050. This triggers the demand for food security and its nutritional value. Despite the advancements in the field of medicine, current research focuses on investigating natural‐origin functional foods with tremendous health‐supporting properties. It includes various natural sources such as animals, plants, algae, fungi, and bacteria. The Algae group is still under investigation to find the best alternative to other previously explored sources. Algae possess remarkable potential for synthesizing natural metabolites, including primary metabolites (polysaccharides, proteins, and lipids) and secondary metabolites (Flavonoids, bromophenols, phenolic compounds, and polyphenols). These bioactive compounds have enormous anticancer, antimicrobial, and neuroprotection applications. This provokes researcher interest in exploring algae strains to optimize their metabolite production to utilize them as a functional food. Metabolomics techniques can be utilized to investigate biological samples. It will create new ways to explore algae strains that have not yet been investigated. A closed pond cultivation system is attractive to enhance algae growth in highly controlled conditions. This review emphasizes algae metabolism, cultivation methods, metabolomics analysis, genetic engineering, and advanced genome editing tools such as the CRISPR CAS9 system, which can be utilized to manipulate the algae genome for increased production.
ER Oxidoreductin 1‐Like Activity of Cyclic Diselenides Drives Protein Disulfide Isomerase in an Electron Relay System
Authors: Mikami Rumi , Nishizawa Yuya , Iwata Yuki , Kanemura Shingo , Okumura Masaki , Arai Kenta 
Published: November 2024

AbstractDisulfide formation generally involves a two‐electron oxidation reaction between cysteine residues. Additionally, disulfide formation is an essential post‐translational modification for the structural maturation of proteins. This oxidative folding is precisely controlled by an electron relay network constructed by protein disulfide isomerase (PDI), with a CGHC sequence as the redox‐active site, and its family enzymes. Creating reagents that mimic the functions of these enzymes facilitates folding during chemical protein synthesis. In this study, we aimed to imitate a biological electron relay system using cyclic diselenide compounds as surrogates for endoplasmic reticulum oxidoreductin 1 (Ero1), which is responsible for the re‐oxidation of PDI. Oxidized PDI (PDIox) introduces disulfide bonds into substrate proteins, resulting in its conversion to reduced PDI (PDIred). The PDIred is then re‐oxidized to PDIox by a coexisting cyclic diselenide compound, thereby restoring the function of PDI as a disulfide‐forming agent. The produced diselenol state is readily oxidized to the original diselenide state with molecular oxygen, continuously sustaining the PDI catalytic cycle. This artificial electron relay system regulating enzymatic PDI function effectively promotes the oxidative folding of disulfide‐containing proteins, such as insulin – a hypoglycemic formulation – by enhancing both yield and reaction velocity.
Single‐dose telitacicept therapy for refractory idiopathic membranous nephropathy: A case series
Authors: Sun Liping , Chen Fuce , Zhang Xinzhou 
Published: November 2024

Key Clinical MessageWe report three cases of IMN from our center, where patients received a single dose of telitacicept after showing no response to conventional treatments. Although one case did not respond, the other two cases achieved complete or partial remission of proteinuria. These cases illustrates the telitacicept may offer new hope for the treatment of IMN.AbstractDespite the variety of treatment options available, effective therapies for refractory membranous nephropathy remain lacking. Recently, some reports have suggested that telitacicept is a new therapeutic option. However, only a few published studies have documented the use of telitacicept for treating idiopathic membranous nephropathy (IMN). We present three cases of IMN from our center, where patients received a single dose of telitacicept after showing no response to conventional treatments, including glucocorticoids, tacrolimus, mycophenolate mofetil, cyclophosphamide, cyclosporine, and rituximab. Although one case did not respond, the other two cases achieved complete or partial remission of proteinuria. Thus, telitacicept may offer new hope for the treatment of refractory membranous nephropathy.
Phosphorus Doped MoO2 Enhanced Pt Catalyst for Methanol Oxidation
Authors: Li Yuanbo , Li Meng , Tursun Mamutjan , Abdukayum Abdukader , Feng Ligang 
Published: November 2024

AbstractThe sluggish kinetics of methanol oxidation reaction (MOR) required high‐performing catalysts in the development of direct methanol fuel cells. Herein, a phosphorus‐doped MoO2 nanorods‐supported Pt catalyst was proposed which exhibited remarkably enhanced catalytic performance toward MOR in comparison with Pt/MoO2 and commercial Pt/C. Specifically, the Pt/MoO2‐P possessed the highest peak current density of 62.63 mA cm−2, about 1.38 and 2.21 times higher than that of Pt/MoO2 (45.24 mA cm−2) and Pt/C (28.40 mA cm−2), respectively. Meanwhile, the Pt/MoO2‐P possessed high intrinsic activity expressed by specific activity and mass activity, and largely improved catalytic kinetics. Moreover, the chronoamperometry and CO‐stripping testing successfully revealed the superior stability and CO‐poisoning resistance of Pt/MoO2‐P, rendering Pt/MoO2‐P a promising catalyst for MOR. The theoretical calculation revealed the electron redistribution and strong metal‐support interaction among Pt/MoO2‐P catalysts. The greatly enhanced catalytic performance could be attributed to the heteroatom doping engineering, greatly enhancing the conductivity, and inducing electron redistribution, thereby leading to the strong metal‐support interaction and high CO‐anti poisoning ability.
Characterization of Chemical Information and Content Prediction of Dendrobium officinale Based on ATR‐FTIR
Authors: Li Peiyuan , Shen Tao , Yang Shaobing , Zuo Zhitian , Wang Yuanzhong , Hu Qiang 
Published: November 2024

ABSTRACTDendrobium officinale is a medicinal and food plant with high commercial and medicinal value. Yunnan is known as China's “plant kingdom,” and although the climatic conditions are favorable, the large vertical climatic differences have led to a large difference in the quality of dendrobium from different origins. The analysis of quality differences between several origins with large ecological advantages has not been reported yet. Therefore, the aim of this study is to compare these regions in terms of both morphology and chemical composition and to analyze the variation of their chemical composition in spectral information. The PLS‐DA, SVM, and PLSR models were developed to qualitatively and quantitatively evaluate Dendrobium from different production areas. The results show that the Menghai production area was superior to other production areas in terms of phenotypic morphology, quality, and yield. Within the appropriate range, the higher the specific absorbance, the higher the quercetin content.
Response of forage sorghum cultivars to different water availability
Authors: Ajoudani Mahmoud Reza , Sayfzadeh Saeed , Valadabadi Seyed Alireza , Shahsavari Nasser , Zakerin Hamidreza 
Published: November 2024

AbstractTo explore the effects of varied irrigation regimes on different sorghum [Sorghum bicolor (L.) Moench] cultivars, a split‐plot experiment adhering to a randomized complete block design with three replications was conducted in 2016 across the Khaveh and Varamin regions. The experimental treatments encompassed irrigation levels as the primary factor and four different sorghum cultivars as the secondary factor. Cultivars exhibiting larger leaf areas were associated with higher chlorophyll content, which enhanced biomass production and the quality of sorghum products. Notable variability in leaf area and crude fiber content was observed across irrigation regimes and cultivars, with 2121 cm2 to 7153 cm2 and 40.4% to 50.7%, respectively. Plant height, total dry weight, and water use efficiency were markedly higher under well‐irrigated conditions than those under moderate and severe water deficit conditions. Specifically, the Pegah cultivar displayed the highest leaf area in the Varamin region, measuring 4612 cm2 and 5911 cm2, whereas the Thin Stem cultivar exhibited the lowest leaf area at both locations. Our findings suggest that the Pegah cultivar maintained a high leaf area without reducing total dry weight, indicating its stability across different environments. Therefore, to produce sorghums in similar climatic conditions, full irrigation is recommended. These results underscore the significance of ongoing research and breeding initiatives to leverage genetic diversity and improve sorghum cultivars.
Distance‐Dependent Symmetry‐Breaking Charge Transfer in 9,10‐ Bis(phenylethynyl)anthracene Dimers
Authors: Wang Xianyuan , Lv Liping , Li Tianyu , Chen Chen , Fan Xiaonan , Cui Boce , Tang Linglong , Chen Yanli , Liu Heyuan , Li Xiyou 
Published: November 2024

AbstractTo investigate the effect of the through‐bond coupling strength on the symmetry‐breaking charge separation (SB‐CS) dynamics and mechanism, three 9,10‐bis((4‐hexylphenyl)ethynyl)anthracene dimers with varying distances, viz., a single‐bond linked dimer (0‐dimer), a phenylene linked dimer (1‐dimer) and a para‐biphenylene linked dimer (2‐dimer), were synthesized and studied systematically using steady‐state and transient spectroscopy. Steady‐state absorption spectra revealed that the electronic coupling strength decreased gradually with the increase of the inter‐chromophore distance, and the transition of S0→S1 includes the dark charge transfer (CT) excitation. fs‐TA spectra demonstrated that SB‐CS could be conducted in both weakly and highly polar solvents for 0‐dimer, but the SB‐CS dynamics has a significant difference. In weakly polar solvents, SB‐CS only produces the partial CT (PCT) state, but it could generate the CT state via the PCT state in highly polar solvent. In comparison, SB‐CS is only proceeded in highly polar solvents in 1‐dimer and 2‐dimer to produce the CT state directly. These results demonstrate that the SB‐CS dynamics is strongly dependent on the inter‐chromophore electronic coupling, and the relatively strong electronic coupling is crucial for the occurrence of SB‐CS in weakly polar environment that is commonly presented in photoelectric devices.