bluuebunny/crossref_metadata_2025_split huggingface dataset:
RAB1B interacts with TRAF3 to promote antiviral innate immunity
Authors: Beachboard Dia C. , Park Moonhee , Vijayan Madhuvanthi , Fernando Dillon J. , Williams Graham D. , Horner Stacy M. 
Published: February 2019

ABSTRACTNucleic acid-based antiviral innate immunity activates a signaling cascade that induces type I and type III interferons (IFNs), and other cytokines. This signaling, which is highly regulated, is initiated by pattern recognition receptors, such as RIG-I, that sense viral RNA and then signal to the adaptor protein, MAVS. This adaptor protein then recruits additional signaling proteins, including TRAF3 and TBK1, to form a signaling complex that results in IRF3 activation for transcriptional induction of IFN. Here, we show that the GTPase trafficking protein RAB1B positively regulates RIG-I signaling to promote IFN-β induction and the antiviral response. Over-expression of RAB1B increases RIG-I-mediated signaling to IFN-β, while deletion results in reduced signaling of this pathway. Additionally, this loss of RAB1B results in a dampened antiviral response, as Zika virus infection is enhanced in the absence of RAB1B. Importantly, we identified the mechanism of RAB1B action by determining that it interacts with TRAF3 to facilitate the interaction of TRAF3 with MAVS. Thus, we identified RAB1B as a regulator of TRAF3 to promote the formation of innate immune signaling complexes in response to nucleic acid sensing.
A primer genetic toolkit for exploring mitochondrial biology and disease using zebrafish
Authors: Sabharwal Ankit , Campbell Jarryd M. , WareJoncas Zachary , Wishman Mark , Ata Hirotaka , Liu Wiebin , Ichino Noriko , Bergren Jake D. , Urban Mark D. , Urban Rhianna , Poshusta Tanya L. , Ding Yonghe , Xu Xiaolei , Clark Karl J. , Ekker Stephen C. 
Published: February 2019

AbstractMitochondria are a dynamic eukaryotic innovation that play diverse roles in biology and disease. The mitochondrial genome is remarkably conserved in all vertebrates, encoding the same 37 gene set and overall genomic structure ranging from 16,596 base pairs (bp) in the teleost zebrafish (Danio rerio) to 16,569 bp in humans. Mitochondrial disorders are amongst the most prevalent inherited diseases affecting roughly 1 in every 5000 individuals. Currently, few effective treatments exist for those with mitochondrial ailments, representing a major unmet patient need. Mitochondrial dysfunction is also implicated to be a common component of a wide variety of other human illnesses ranging from neurodegenerative disorders like Huntington’s disease and Parkinson’s disease to autoimmune illnesses such as multiple sclerosis and rheumatoid arthritis. The electron transport chain (ETC) component of mitochondria is critical for mitochondrial biology and defects can lead to many mitochondrial disease symptoms. Here we present a publicly available collection of genetic mutants created in highly conserved, nuclear-encoded mitochondrial genes inDanio rerio. The zebrafish system represents a potentially powerful new opportunity for the study of mitochondrial biology and disease due to the large number of orthologous genes shared with humans and the many advanced features of this model system from genetics to imaging. This collection includes 22 mutant lines in 18 different genes created by locus-specific gene editing to induce frameshift or splice acceptor mutations leading to predicted protein truncation during translation. Also included are 6 lines created by the random insertion of the gene-breaking transposon (GBT) protein trap cassette. All of these targeted mutant alleles truncate conserved domains of genes critical to the proper function of the ETC or genes that have been implicated in human mitochondrial disease. This collection is designed to accelerate the use of zebrafish to study of many different aspects of mitochondrial function with the goal of widening our understanding of their role in biology and human disease.
Electrical coupling controls dimensionality and chaotic firing of inferior olive neurons
Authors: Hoang Huu , Lang Eric J. , Hirata Yoshito , Tokuda Isao T. , Aihara Kazuyuki , Toyama Keisuke , Kawato Mitsuo , Schweighofer Nicolas 
Published: February 2019

SUMMARYOne of the main challenges facing online neural learning systems with numerous modifiable parameters (or “degrees-of-freedom”) such as the cerebellum, is how to avoid “overfitting”. We previously proposed that the cerebellum controls the degree-of-freedoms during learning by gradually modulating the electric coupling strength between inferior olive neurons. Here, we develop a modeling technique to estimate effective coupling strengths between inferior olive neurons from in vivo recordings of Purkinje cell complex spike activity in three different coupling conditions. We show that high coupling strengths induce synchronous firing and decrease the dimensionality of inferior olive firing dynamics. In contrast, intermediate coupling strengths induce chaotic firing and increase the dimensionality of firing dynamics. Our results thus support the hypothesis that effective coupling controls the dimensionality of inferior olive firing, which may allow the olivocerebellar system to learn effectively from a small training sample set despite the low firing frequency of inferior olive neurons.
The school-to-work transition, overeducation and wages of youth in Kyrgyzstan
Authors: Karymshakov Kamalbek , Sulaimanova Burulcha 
Published: February 2019

PurposeThe purpose of this paper is twofold: first, it analyses the relationship between educational level, the school-to-work transition period for youth and positions which suffer from an education-job mismatch in Kyrgyzstan; and second, it investigates the effect of the education-job mismatch on the wages of youth in Kyrgyzstan.Design/methodology/approachThe study uses the International Labor Organization 2013 data from the school-to-work transition survey for Kyrgyzstan. The Kaplan–Meier failure analysis is employed to demonstrate the relationship between school-to-work transition and mismatch status. To investigate the effect of an education-job mismatch on wages, a Mincer-type equation with OLS estimations is used. Along with this, taking into consideration potential unobserved heterogeneity issue, a propensity score matching method is applied.FindingsThe results indicate a large difference between those with tertiary education and those with non-tertiary education in terms of the probability of being employed with a wrong match. Young individuals without tertiary education are more likely to be employed with a right match. Analysis of the impact of overeducation on wages shows that the impact of overeducation depends on how it is measured. According to the objective approach, overeducated male individuals receive low wages compared to well matched, but estimation results based on the total sample of subjective approach indicate the positive effects of overeducation on wage.Originality/valueThis paper contributes to the existing literature on the school-to-work transition and overeducation by focusing on one of the transition economies, which has been largely neglected by the literature.
Organizational justice, conflict management and employee relations
Authors: Sahoo Rojalin , Sahoo Chandan Kumar 
Published: February 2019

PurposeThe purpose of this paper is to examine the impact of organizational justice and conflict management on employee relations (ER) through the mediating role of climate of trust.Design/methodology/approachThis study was conducted with a sample of 331 employees working in a power transmission unit of Odisha. Data were collected by administering a structured questionnaire and analyzed using structural equation modeling (AMOS 20).FindingsThe results reveal that climate of trust plays the role of a partial mediator between organizational justice and ER and conflict management and ER. Also, it was found that organizational justice, conflict management and climate of trust are the positive and significant predictors of ER.Research limitations/implicationsThe study was confined to a single state-owned power transmission unit of an Indian state, which restricts its generalizability. The research would benefit from exploration in alternative units.Practical implicationsThis scholarly work may encourage managers and decision makers to develop trust building climate by focusing on organizational justice and conflict management to flourish an environment of harmonious ER, furthermore to formulate effective strategies for cultivating facilitative work environment to enhance positive attitude among the employees to challenge future goals.Originality/valueThe research is exclusive in determining the influence of organizational justice and conflict management on ER through the mediator of climate of trust in the new perspective of the power sector that provides empirical evidence to the extant literature.
Co-movement dynamics between global sukuk and bond markets
Authors: Bhuiyan Rubaiyat Ahsan , Rahman Maya Puspa , Saiti Buerhan , Mat Ghani Gairuzazmi 
Published: February 2019

PurposeMarket links (and price discovery) between financial assets and lead–lag relationships are topics of interest for financial economists, financial managers and analysts. The lead–lag relationship analysis should consider both short and long-term investors. From a portfolio diversification perspective, the first type of investor is generally more interested in determining the co-movement of financial assets at higher frequencies, which are short-run fluctuations, while the latter concentrates on the relationship at lower frequencies, or long-run fluctuations. The paper aims to discuss these issues.Design/methodology/approachFor this study, a technique was employed known as the wavelet approach, which has recently been imported to finance from engineering sciences to study the co-movement dynamics between global sukuk and bond markets. Data cover the period from January 2010 to December 2015.FindingsThe results indicate that: there is no unidirectional causality from developed market bond indices to Malaysia and Dow Jones indices, which is promising for fixed-income investors of a developed market; and in relation to emerging markets, the Malaysian sukuk market has a bidirectional causality with Indonesia, Malaysia, India and South Korea bond indices but not China bond indices, while in terms of the Dow Jones sukuk index, there is no unidirectional causality between the listed emerging markets and the sukuk index except Indonesia’s market during the sample period.Research limitations/implicationsThis analysis provides evidence regarding the timely and appropriate measure of correlation changes and the behaviour of sukuk and bond indices globally, which is beneficial to the management of sukuk and bond portfolios.Originality/valueThe evidence hitherto unexplored, which was produced by the application of a wavelet cross-correlation amongst the selected sukuk and bond indices, provides robust and useful information for international financial analysts as well as long and short-term investors.
Quality management vision of future early career operations managers
Authors: Shokri Alireza , Nabhani Farhad 
Published: February 2019

PurposeThe purpose of this paper is to investigate the gap between the current vision and knowledge of future early career operations managers (OM) and a common strategic total quality management (TQM) framework.Design/methodology/approachA survey questionnaire and a non-parametric test for different groups of participants were adopted to identify the gap and analyse the significance of these groups on the factors in the TQM framework.FindingsA new set of TQM factors with the necessity of more knowledge and understanding of future generation were identified, followed by the identification of clear differences amongst different groups of this generation.Practical implicationsA sustainable OM practice needs managers and leaders with a sustainable knowledge development of quality management (QM); and as the result of this study, the current vision of future young OM would not echo this.Originality/valueThis study has a systematic, non-parametric approach towards currently fragmented QM analysis, and is integrated with human resource and visionary elements of future young OM and universal QM models and theories.
Stochastic modelling and availability analysis of a critical engineering system
Authors: Gupta Sorabh 
Published: February 2019

Purpose
The purpose of this paper is to present the technique for evaluating the performance of a condensate system of a coal-based thermal power plant situated in the northern part of India. The data which used for system availability evaluation are not precise and are uncertain and, further, collected from concerned power plant history sheets and from discussion through plant personnel.

Design/methodology/approach
In the proposed model, traditional Markov birth-death process using a probabilistic approach is used to analyze the performance of a complex repairable condensate system of power plant up to a desired degree of accuracy. This approach has been demonstrated by breaking the condensate system into six subsystems arranged in series with two feasible states, namely, working and failed, labeled in a transition diagram and modeled as a Markov process, using Chapman–Kolmogorov equations, which are used for development of a probabilistic stochastic model for availability analysis in a more effecting manner, considering some suitable assumptions.

Findings
This study of analysis of reliability and availability can help in increasing the plant production and performance. The analysis is done with the help of availability matrices, which are developed using different combinations of failures and repair rates of all subsystems. To achieve the goal of maximum power generation, it is required to run the various subsystem of the concerned system of plant, failure free for a long duration. Therefore, the present approach may be a more powerful analysis tool to access the performance of all subsystems of a condensate system in terms of availability level achieved in availability matrices. The results of present study are found to be highly beneficial to the plant management for making maintenance decisions.

Originality/value
The present paper suggests a suitable technique for stochastic modeling and availability evaluation of an industrial system using Markovian approach and drawing a transition diagram to represent the operational behavior of the system. The present methodology includes the advantage of the ability to model and develop a more complex industrial system and helps in improving the performance and handling the uncertainties and possibilities of an industrial system.
Signature reliability of binary state node in complex bridge networks using universal generating function
Authors: Bisht Soni , Singh S.B. 
Published: February 2019

PurposeThe purpose of this paper is to evaluate various reliability measures like reliability, expected lifetime (mean time to failure), signature reliability and compare networks based on the different flows.Design/methodology/approachThe reliability characteristics of complex bridge networks have been evaluated using different algorithms with the help of universal generating function (UGF). Further, the signature reliability of the considered networks has been determined using Owen’s method.FindingsThe present paper proposes an efficient algorithm to compute the reliability indices of complex bridge networks having i.i.d. lifetime components (nodes, edges) with the help of UGF and Owen’s method. This study reveals that a slight change in the complex bridge network affects the reliability significantly. Finally, by the reliability structure function, proposed algorithms are used to find the signature and MTTF. From signature, we have determined the different failure probabilities corresponding to edges of the network.Originality/valueIn this work, we have evaluated reliability characteristics and signature reliability of the complex bridge networks using UGF method and Owen’s method respectively unlike done in the past.
Co-authorship networks of Argentine economists
Authors: Larrosa Juan M.C. 
Published: February 2019

Purpose
This paper aims to provide information about the structure of collaborative work among Argentinian economics. The study provides specific applied research of social network analysis focus on this profession in this specific country.

Design/methodology/approach
The contribution opted for applying social network analysis tools to papers presented in a congress and published in its proceedings. The authors focus in detecting main actors, groups of co-authorship, professionals acting as bridges between groups and differences between genders.

Findings
The paper provides empirical insights about how co-authorship has evolved between Argentine economists. The authors find that structural properties of the network, main actors, both male and female, main universities or center that affiliates them, a gender gap that might be closing out.

Research limitations/implications
The paper focuses on the network for the period 1964-2014 without a more detailed dynamic. It also does not explain main topics worked by the authors.

Practical implications
The work provides knowledge about how groups are created in Economics in Argentina, how cooperation has evolved and what has been the role of women in this development. It also shows how different departments and entities collaborate with diverse success in the creation of new knowledge in Economics in Argentina.

Originality/value
The paper works with data from a source of information non-previously studied and contributes in explaining a particular type of collaborative work in a profession in Argentina.
The role of knowledge and organizational support in explaining managers’ active risk management behavior
Authors: Kim Sang Soo 
Published: February 2019

PurposeEffective risk management (RM) requires not only proactive prevention, but also reactive response where the role of individual managers is pivotal as they are the main players to perform RM behavior. Hence, the key questions related to effective corporate RM can be identified as how actively managers engage in RM behaviors and how well the firm supports their RM behavior. The purpose of this paper is to understand the mechanism of managers’ engagement in an active RM behavior and highlight the role of knowledge and organizational support in explaining the mechanism.Design/methodology/approachA structural model built on the theory of planned behavior and the institutional theory is proposed to empirically examine the factors affecting managers’ RM intention. The survey of 150 senior managers from different divisions of six major companies in Korean food industry was conducted.FindingsThe data analysis brings forward three key findings: individual factors (behavioral belief about RM, social pressure and RM knowledge) positively influence RM intention; organizational factor (organizational RM support) positively affects managers’ RM knowledge; and both individual and organizational factors are affected by organizational environment and/or RM championship.Originality/valueThis study contributes to the literature by identifying the mechanism in that managers perform RM behavior voluntarily. This study also contributes to the practice by informing practitioners of the importance of implementing a company-wide RM system and motivating managers for an active RM behavior.
Finding a turn in Canadian management through archival sources
Authors: Russell Jason 
Published: February 2019

Purpose
The purpose of this paper is to reveal something about a turn that occurred in Canadian management from the 1960s to 1980s through an empirical analysis of three different archival research sources. It considers three sub-themes that collectively help to reveal empirically major changes in management identity that happened in Canada from the late 1960s to the early 1980s.

Design/methodology/approach
This paper is divided into several sub-sections and uses social history methodology, although it is principally intended to be an empirical analysis. The rationale for selecting three specific sources and how they relate to each other is discussed. The sources are different in terms of form and periodization, yet they collectively provide coherent insights into the management experience in Canada from the 1960s to 1980s.

Findings
As a methodology paper, this analysis reveals the unique nature of archival sources that are not often found in management history and also shows how they relate to each other.

Research limitations/implications
This paper may seem specific to Canadian management history, but it is intended to present sources and methodology that are applicable regardless of locale.

Originality/value
This paper seeks to present the value of using new methodologies in the study of management history and, while building on existing literature, it helps to reveal the complexity of the management experience in important decades in post-Second World War Canada.
Family influence mediates the relation between helicopter-parenting and millennial work attitudes
Authors: Gomes Shelomi B. , Deuling Jacqueline K. 
Published: February 2019

PurposeDrawing from life course theory, the purpose of this paper is to investigate the mediating role of family influence on career development (FICD) on the relationship of helicopter-parenting (over-parenting behavior) and US millennials’ work attitudes.Design/methodology/approachIn Study 1 (n=268), confirmatory factor analysis was tested on all scales to derive fit models. Mediation analyses using PROCESS (Preacher and Hayes, 2004) were conducted on Study 1 and Study 2 (n=196) on survey collected data sets.FindingsCapturing life course theorists’ proposition that parental involvement now extends itself through childhood and into millennials’ adulthood, results from both studies indicate helicopter-parenting is related to FICD. Further, for both studies, information support (FICD factor) positively mediates the relationship between helicopter-parenting and, affective commitment and job satisfaction, and negatively mediates the relationship between helicopter-parenting and turnover intentions. Additionally, direct effects on helicopter-parenting on work outcomes were found in both studies.Practical implicationsCEOs and managers seem perplexed on how to manage millennial workers. Understanding the co-occurring positive and negative effects of the millennial-parent relationship on work attitudes can help alleviate this conundrum to create better supervision, retention and engagement of millennial workers.Originality/valueThis study contributes to the sparse empirical literature on millennial’s work attitudes and is the first to provide empirical evidence of the role parents play in shaping millennial’s work attitudes. The findings highlight the concerns CEOs have in managing their millennial workers via their parental relationship and provide insightful management strategies.