bluuebunny/crossref_metadata_2025_split huggingface dataset:
30 Years of Lithium‐Ion Batteries
Authors: Li Matthew , Lu Jun , Chen Zhongwei , Amine Khalil 
Published: June 2018

AbstractOver the past 30 years, significant commercial and academic progress has been made on Li‐based battery technologies. From the early Li‐metal anode iterations to the current commercial Li‐ion batteries (LIBs), the story of the Li‐based battery is full of breakthroughs and back tracing steps. This review will discuss the main roles of material science in the development of LIBs. As LIB research progresses and the materials of interest change, different emphases on the different subdisciplines of material science are placed. Early works on LIBs focus more on solid state physics whereas near the end of the 20th century, researchers began to focus more on the morphological aspects (surface coating, porosity, size, and shape) of electrode materials. While it is easy to point out which specific cathode and anode materials are currently good candidates for the next‐generation of batteries, it is difficult to explain exactly why those are chosen. In this review, for the reader a complete developmental story of LIB should be clearly drawn, along with an explanation of the reasons responsible for the various technological shifts. The review will end with a statement of caution for the current modern battery research along with a brief discussion on beyond lithium‐ion battery chemistries.
Farmer perceptions of risk in 2017
Authors: Thompson Nathanael M. , Bir Courtney , Widmar Nicole J. Olynk 
Published: June 2018

AbstractAgribusinesses seeking to serve farmer clientele, as well as those buying products from the farm for processing or transport, need to understand the factors impacting on‐farm decision making. A best–worst choice experiment was employed to determine farmer perceptions of five general risk areas: production, marketing, financial, human, and legal risks. Results indicate, on average, farmers were more concerned with traditional farm business risks (production, financial, and marketing risks) relative to human and legal risks when managing their farm businesses. However, significant heterogeneity in perceptions of risk areas was observed. A latent class model identified three segments of producers that were characterized by preferences for traditional farm business risks, well‐balanced preferences for all five risks, and a large preference share for human risks. Understanding how different farm types and managers with varying demographics prioritize risk areas is helpful for targeting specific risk management programming and support services to relevant farm audiences. [EconLit citations: Q1].
Radiation degradation and stability of PBAT: copolymer of aromatic and aliphatic esters
Authors: Rzepna Magdalena , Przybytniak Grażyna , Sadło Jarosław 
Published: June 2018

ABSTRACTEffect of the exposure of poly(butylene adipate‐co‐terephthalate) (PBAT) to ionizing radiation was studied by means of EPR and diffuse reflection spectroscopy, GC, and gel permeation chromatography. In addition, the influence of radiation‐induced processes on mechanical and rheological properties for the doses in the range 0–200 kGy was investigated. The macroscopic consequences of PBAT irradiation included: crosslinking, chain cleavage, and oxidation, which led to the significant modification of physicochemical features. The crosslinking process occurred even under cryogenic conditions and was confirmed by reduction in melt flow index (MFI), increase in viscosity, and weight‐average molecular weight with increasing dose. Material degradation during long‐term storage was accompanied by deterioration of mechanical properties, increase in MFI, and viscosity reduction. Oxidation of the copolyester had a chain character and increased over time, especially in the case of irradiated PBAT. Despite the presence of aromatic rings dissipating energy, the material is susceptible to ionizing radiation. The regions containing terephthalates are involved in the aging processes; the appropriate mechanisms have been proposed. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46682.
Bacterial Catabolism of Biphenyls: Synthesis and Evaluation of Analogues
Authors: Nerdinger Sven , Kuatsjah Eugene , Hurst Timothy E. , Schlapp‐Hackl Inge , Kahlenberg Volker , Wurst Klaus , Eltis Lindsay D. , Snieckus Victor 
Published: June 2018

AbstractA series of alkylated 2,3‐dihydroxybiphenyls has been prepared on the gram scale by using an effective Directed ortho Metalation–Suzuki–Miyaura cross‐coupling strategy. These compounds have been used to investigate the substrate specificity of the meta‐cleavage dioxygenase BphC, a key enzyme in the microbial catabolism of biphenyl. Isolation and characterization of the meta‐cleavage products will allow further study of related processes, including the catabolism of lignin‐derived biphenyls.
Rhenium Complexes of Bis(benzothiazole)‐Based Tetraarylethylenes as Selective Luminescent Probes for Amyloid Fibrils
Authors: Gabr Moustafa T. , Pigge F. Christopher 
Published: June 2018

AbstractProbes for monitoring aggregation of amyloid beta (Aβ) peptides are crucial to advance understanding of the molecular pathogenesis of Alzheimer's Disease (AD). Here, we report luminescent tricarbonyl rhenium complexes of tetraarylethylene (TAE) ligands featuring bis(benzothiazole) chelating groups in combination with (oligo)thiophene units that have been designed for monitoring amyloid fibrillation. Variation in the number of thiophenes influenced the photophysical properties of these complexes, as well as their binding affinities toward Aβ42 fibrils. All complexes displayed submicromolar Kd's for binding Aβ42 aggregates accompanied by up to 34‐fold enhanced luminescence and red‐shifted emission wavelengths. The high binding affinities and desirable photophysical properties of these complexes render them potential alternatives to established fluorescent Aβ probes such as thioflavin T. Additionally, the general and modular design approach implemented in this study should facilitate development of second‐generation TAE‐based diagnostic tools for studying protein aggregation in AD and other neurological diseases.
Flexible MnS–Carbon Fiber Hybrids for Lithium‐Ion and Sodium‐Ion Energy Storage
Authors: Gao Shuang , Chen Gang , Dall'Agnese Yohan , Wei Yingjin , Gao Zhongmin , Gao Yu 
Published: June 2018

AbstractNanostructures can improve battery capacity and cycle life, especially with sulfide electrodes. In this work, a freestanding flexible electrode, consisting of MnS nanoparticles embedded onto carbon nanofibers, was prepared by electrospinning. The produced hybrid was used as an electrode for lithium‐ion and sodium‐ion batteries. MnS nanoparticles have a size of about 5 nm and the particles are evenly distributed in the carbon nanofibers. Carbon nanofibers act as electronic conductors and buffer the volume change, while MnS nanoparticles react through rapid electrochemical reaction. As a Li‐ion battery anode, this hybrid electrode exhibits specific capacities from 240 mAh g−1 at a high current density of 5 A g−1, up to 600 mAh g−1 at 200 mA g−1.
Nano‐resoles‐Enabled Elegant Nanostructured Materials
Authors: Zhang Min , Yang Yannan , Yu Chengzhong 
Published: June 2018

AbstractSince the extension of the Stöber method traditionally used in the synthesis of silica nanoparticles into the fabrication of resorcinol–formaldehyde nanospheres in 2011, significant progresses have been achieved in this exiting area of nano‐resole‐enabled synthesis of elegant nanostructures with versatile compositions and promising applications in various fields. To date, there are few reviews focused on this topic. In this minireview, we aim to provide an overview on recent developments, with the emphasis on nano‐resoles as an enabling strategy in the synthesis of innovative materials. The history of nano‐resoles and their distinct roles classified into four functions will be introduced. Clear understanding into this research field is vital for achieving rational design and controllable synthesis of a new generation of nano‐resoles and their derived nanostructures.
Copper‐Mediated Trifluoromethylation of Benzylic Csp3−H Bonds
Authors: Paeth Matthew , Carson William , Luo Jheng‐Hua , Tierney David , Cao Zhi , Cheng Mu‐Jeng , Liu Wei 
Published: June 2018

AbstractTrifluoromethyl‐containing compounds play a significant role in medicinal chemistry, materials and fine chemistry. Although direct C−H trifluoromethylation has been achieved on Csp2−H bonds, direct conversion of Csp3−H bonds to Csp3−CF3 remains challenging. We report herein an efficient protocol for the selective trifluoromethylation of benzylic C−H bonds. This process is mediated by a combination CuIII−CF3 species and persulfate salts. A wide range of methylarenes can be selectively trifluoromethylated at the benzylic positions. A combination of experimental and theoretical mechanistic studies suggests that the reaction involves a radical intermediate and a CuIII−CF3 species as the CF3 transfer reagent.
Life stress as a risk factor for sustained anxiety and cortisol dysregulation during the first year of survivorship in ovarian cancer
Authors: Armer Jessica S. , Clevenger Lauren , Davis Lauren Z. , Cuneo Michaela , Thaker Premal H. , Goodheart Michael J. , Bender David P. , Dahmoush Laila , Sood Anil K. , Cole Steven W. , Slavich George M. , Lutgendorf Susan K. 
Published: June 2018

BACKGROUNDPatients with ovarian cancer often report elevated anxiety at diagnosis that decreases posttreatment. However, a minority of patients experience sustained anxiety. Few studies have examined risk factors for persistent anxiety or its physiologic sequelae in ovarian cancer. Therefore, the authors investigated associations between prior life events, anxiety, inflammation (plasma levels of interleukin‐6), and diurnal cortisol profiles in patients with ovarian cancer during the first year postdiagnosis.METHODSParticipants (n = 337) completed surveys and had blood and salivary sampling prediagnosis, postchemotherapy (6 months), and 12 months after diagnosis. The Life Events and Difficulties Schedule was administered to a patient subset (n = 127) within 1 month of diagnosis. Linear mixed‐effects models were used to analyze relations between anxiety and biologic variables over time. Linear regression models assessed whether anxiety trajectories mediated associations between prior stress exposure and biologic variables. Age, chemotherapy at 1 year, and cancer stage were covariates.RESULTSDecreased anxiety was associated with a more normalized cortisol slope over time (β = 0.092; P = .047). Early life adversity was related to flatter cortisol slopes over time (β = −0.763; P = .002); this relation was partially mediated by anxiety trajectory (P = .046). More danger‐related events prediagnosis were associated with sustained anxiety (β = 0.537; P = .019) and flatter cortisol slopes over time (β = −0.243; P = .047); anxiety partially mediated the relation between danger and cortisol slope (P = .037). Neither anxiety nor prior stress exposure was related to levels of interleukin‐6.CONCLUSIONSBecause dysregulated cortisol has been related to fatigue, poorer quality of life, and shorter survival in patients with ovarian cancer, those who have prior life events and chronic anxiety during the first year postdiagnosis may be at risk for more negative outcomes. Cancer 2018. © 2018 American Cancer Society.
Beyond classic risk adjustment: Socioeconomic status and hospital performance in urologic oncology surgery
Authors: Odisho Anobel Y. , Etzioni Ruth , Gore John L. 
Published: June 2018

BACKGROUNDSafety‐net hospitals (SNHs) care for more patients of low socioeconomic status (SES) than non‐SNHs and are disproportionately punished under SES‐naive Medicare readmission risk‐adjustment models. This study was designed to develop a risk‐adjustment framework that incorporates SES and to assess the impact on readmission rates.METHODSCalifornia Office of Statewide Health Planning and Development data from 2007 to 2011 were used to identify patients undergoing radical cystectomy (RC) for bladder cancer (n = 3771) or partial nephrectomy (PN; n = 5556) or radical nephrectomy (RN; n = 13,136) for kidney cancer. Unadjusted hospital rankings and predicted rankings under models simulating the Medicare Hospital Readmissions Reduction Program were compared with predicted rankings under models incorporating SES and hospital factors. SES, derived from a multifactorial neighborhood score, was calculated from US Census data.RESULTSThe 30‐day readmission rate was 26.1% for RC, 8.3% for RN, and 9.5% for PN. The addition of SES, geographic, and hospital factors changed hospital rankings significantly in comparison with the base model (P < .01) except for SES for RC (P = .07) and SES and rural factors for PN (P = .12). For RN and PN, the addition of SES predicted lower percentile ranks for SNHs and thus improved observed‐to‐expected rankings (P < .01). For RC, there were no changes in hospital rankings.CONCLUSIONSSES is important for risk adjustments for complex surgical procedures such as RC. Patient SES affects overall hospital rankings across cohorts, and critically, it differentially and punitively affects rankings for SNHs for some procedures. Cancer 2018. © 2018 American Cancer Society.
Renaissance of the Stella Quadrangula: The Lanthanoid Nitride Tellurides Ln13N5Te12 (Ln = La–Nd)
Authors: Lissner Falk , Foltin Markus L. , Schleid Thomas 
Published: June 2018

AbstractInvited for the cover of this issue is the group of Thomas Schleid from the University of Stuttgart, Germany. The cover image shows how both cationic components [N2Ln6]12+ and [N3Ln7]12+ in the title compounds Ln13N5Te12 (Ln = La–Nd) derive from a hypothetic stella quadrangula [N4Ln8]12+ of four edge‐sharing [NLn4]9+ tetrahedra by removal of the appropriate number of LnN equivalents.
Is there indirect selection on female extra-pair reproduction through cross-sex genetic correlations with male reproductive fitness?
Authors: Reid Jane M. , Wolak Matthew E. 
Published: June 2018

AbstractOne key hypothesis explaining the evolution and persistence of polyandry, and resulting female extra-pair reproduction in socially monogamous systems, is that female propensity for extra-pair reproduction is positively genetically correlated with male reproductive fitness and consequently experiences positive cross-sex indirect selection. However, key genetic correlations have rarely been estimated, especially in free-living populations experiencing natural (co)variation in reproductive strategies and fitness. We used long-term life-history and pedigree data from song sparrows (Melospiza melodia) to estimate the cross-sex genetic correlation between female propensity for extra-pair reproduction and adult male lifetime reproductive success, and thereby test a key hypothesis regarding mating system evolution. There was substantial additive genetic variance in both traits, providing substantial potential for indirect selection on female reproductive strategy. However, the cross-sex genetic correlation was estimated to be close to zero. Such small correlations might arise because male reproductive success achieved through extra-pair paternity was strongly positively genetically correlated with success achieved through within-pair paternity, implying that the same successful males commonly sire offspring produced by polyandrous and monogamous females. Cross-sex indirect selection may consequently have limited capacity to drive evolution of female extra-pair reproduction, or hence underlying polyandry, in systems where multiple routes to paternity success exist.
A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk
Authors: Luu Hung. N. , Cai Hui , Murff Harvey J. , Xiang Yong‐Bing , Cai Qiuyin , Li Honglan , Gao Jing , Yang Gong , Lan Qing , Gao Yu‐Tang , Zheng Wei , Shu Xiao‐Ou 
Published: June 2018

Animal studies have shown that polyunsaturated fatty acids (PUFAs) have antineoplastic and anti‐inflammatory properties. Results from epidemiologic studies on specific types of PUFAs for lung cancer risk, however, are inconclusive. We prospectively evaluated the association of specific types of dietary PUFA intakes and lung cancer risk in two population‐based cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS) with a total of 121,970 study participants (i.e., 65,076 women and 56,894 men). Dietary fatty acid intakes were derived from data collected at the baseline using validated food frequency questionnaires (FFQs). Cox proportional hazards model was performed to assess the association between PUFAs and lung cancer risk. Total, saturated and monounsaturated fatty acid intakes were not significantly associated with lung cancer risk. Total PUFAs intake was inversely associated with lung cancer risk [HRs and respective 95% CIs for quintiles 2–5 vs quintile 1: 0.84 (0.71–0.98), 0.97 (0.83–1.13), 0.86 (0.74–1.01) and 0.85 (0.73–1.00), ptrend = 0.11]. However, DHA intake was positively associated with lung cancer risk [HRs and 95% CIs: 1.01 (0.86–1.19), 1.20 (1.03–1.41), 1.21 (1.03–1.42) and 1.24 (1.05–1.47), ptrend = 0.001]. The ratio of n‐6 PUFAs to n‐3 PUFAs (i.e., 7:1) was inversely associated with lung cancer risk, particularly among never‐smokers and adenocarcinoma patients. Total PUFAs and the ratio between n‐6 PUFAs and n‐3 PUFAs were inversely associated with lung cancer risk. This study highlights an important public health impact of PUFA intakes toward intervention/prevention programs of lung cancer.
Retracted: Inhibition of Notch signaling pathway enhanced the radiosensitivity of breast cancer cells
Authors: Peng Jian‐Heng , Wang Xiao‐Lin , Ran Liang , Song Jun‐Long , Zhang Zhi‐Ting , Liu Xin , Li Hong‐Yuan 
Published: June 2018

AbstractThis study aimed to investigate the effect of inhibiting the Notch signaling pathway on the radiosensitivity of breast cancer cells. Human breast cancer cell lines (MCF‐7 and T47D) were selected and treated with radiation of different doses. Cells were treated with Gamma secretase inhibitor (GSI) to analyze the effects of GSI on the Notch signaling, which were detected by Immunofluorescence assay, RT‐qPCR, and Western blot analysis. Besides, Transwell assay, Scratch test, colony formation assay, MTT assay, and flow cytometry were conducted to show the effects of GSI on the invasion and migration, survival fraction, cell viability, and apoptosis of MCF‐7 and T47D cells after radiation therapy. Moreover, cell transfection with a dominant negative mutant of RBPJ, the key transcription factor of Notch signaling pathway, were also applied to show the inhibition of Notch signaling pathway. Initially, we found that the 4 Gy radiation activated Notch signaling pathway, and enhanced the invasion and migration of MCF‐7 and T47D cells. However, GSI inhibited the Notch signaling pathway, and reversed the enhancement of radiation on the migration and invasion, promoted the enhancement of apoptosis and inhibition of proliferation of MCF‐7 and T47D cells induced by radiation. Except that, we also determined that GSI and dnRBPJ suppressed the upregulation of Notch signaling after radiation therapy. Our study demonstrated that inhibition of the Notch signaling pathway enhanced the radiosensitivity of breast cancer cells, which may provide evident for a beneficial adjuvant therapy in the breast cancer treatment.
Identification of gene expression profiles and key genes in subchondral bone of osteoarthritis using weighted gene coexpression network analysis
Authors: Guo Sheng‐Min , Wang Jian‐Xiong , Li Jin , Xu Fang‐Yuan , Wei Quan , Wang Hai‐Ming , Huang Hou‐Qiang , Zheng Si‐Lin , Xie Yu‐Jie , Zhang Chi 
Published: June 2018

AbstractOsteoarthritis (OA) significantly influences the quality life of people around the world. It is urgent to find an effective way to understand the genetic etiology of OA. We used weighted gene coexpression network analysis (WGCNA) to explore the key genes involved in the subchondral bone pathological process of OA. Fifty gene expression profiles of GSE51588 were downloaded from the Gene Expression Omnibus database. The OA‐associated genes and gene ontologies were acquired from JuniorDoc. Weighted gene coexpression network analysis was used to find disease‐related networks based on 21756 gene expression correlation coefficients, hub‐genes with the highest connectivity in each module were selected, and the correlation between module eigengene and clinical traits was calculated. The genes in the traits‐related gene coexpression modules were subject to functional annotation and pathway enrichment analysis using ClusterProfiler. A total of 73 gene modules were identified, of which, 12 modules were found with high connectivity with clinical traits. Five modules were found with enriched OA‐associated genes. Moreover, 310 OA‐associated genes were found, and 34 of them were among hub‐genes in each module. Consequently, enrichment results indicated some key metabolic pathways, such as extracellular matrix (ECM)‐receptor interaction (hsa04512), focal adhesion (hsa04510), the phosphatidylinositol 3'‐kinase (PI3K)‐Akt signaling pathway (PI3K‐AKT) (hsa04151), transforming growth factor beta pathway, and Wnt pathway. We intended to identify some core genes, collagen (COL)6A3, COL6A1, ITGA11, BAMBI, and HCK, which could influence downstream signaling pathways once they were activated. In this study, we identified important genes within key coexpression modules, which associate with a pathological process of subchondral bone in OA. Functional analysis results could provide important information to understand the mechanism of OA.
The lncRNA TP73‐AS1 promotes ovarian cancer cell proliferation and metastasis via modulation of MMP2 and MMP9
Authors: Wang Xiaoqian , Yang Bing , She Yuanping , Ye Yuan 
Published: June 2018

AbstractOvarian cancer is one of the most common gynecologic malignancy with poor prognosis. Recently, long noncoding RNAs (lncRNAs) have been identified as key regulators in cancer development. The current study investigated the role of lncRNA P73 antisense RNA 1T (TP73‐AS1) in ovarian cancer. Quantitative real‐time polymerase chain reaction determined the expression levels of TP‐73AS1, matrix metallopeptidases (MMPs) messenger RNA. Cell proliferative ability, cell invasion, and migration were CCK‐8 and colony formation, and transwell invasion and migration assays, respectively. The protein levels of matrix metallopeptidase 2 (MMP2) and MMP9 were measured by Western blot. TP73‐AS1 was upregulated in the ovarian cancer tissues and ovarian cancer cells, and upregulation of TP73‐AS1 was associated with poor prognosis. Knockdown of TP73‐AS1 significantly suppressed cell proliferation, invasion, and migration of SKOV3 cells, and overexpression of TP73‐AS1 promoted cell proliferation, invasion, and migration of OVCA429 cells. In addition, knockdown of TP73‐AS1 suppressed the in vivo tumor growth. Tumor metastasis RT2 profiler polymerase chain reaction array showed that MMP2 and MMP9 was significantly upregulated by TP73‐AS1 overexpression in ovarian cancer cells. TP73‐AS1 overexpression enhanced the expression of MMP2 and MMP9 in ovarian cancer cells. Knockdown of MMP2 and MMP9 attenuated the effects of TP73‐AS1 overexpression on cell invasion and migration. The clinical data showed that MMP2 and MMP9 were upregulated and positively correlated with TP73‐AS1 expression in ovarian cancer tissues. Collectively, our results demonstrated the oncogenic role of TP73‐AS1 in ovarian cancer, and targeting TP73‐AS1 may represent a novel approach in battling against ovarian cancer.