bluuebunny/crossref_metadata_2025_split huggingface dataset:
The National Sleep Research Resource: towards a sleep data commons
Authors: Zhang Guo-Qiang , Cui Licong , Mueller Remo , Tao Shiqiang , Kim Matthew , Rueschman Michael , Mariani Sara , Mobley Daniel , Redline Susan 
Published: April 2018

Abstract

Objective
The gold standard for diagnosing sleep disorders is polysomnography, which generates extensive data about biophysical changes occurring during sleep. We developed the National Sleep Research Resource (NSRR), a comprehensive system for sharing sleep data. The NSRR embodies elements of a data commons aimed at accelerating research to address critical questions about the impact of sleep disorders on important health outcomes.

Approach
We used a metadata-guided approach, with a set of common sleep-specific terms enforcing uniform semantic interpretation of data elements across three main components: (1) annotated datasets; (2) user interfaces for accessing data; and (3) computational tools for the analysis of polysomnography recordings. We incorporated the process for managing dataset-specific data use agreements, evidence of Institutional Review Board review, and the corresponding access control in the NSRR web portal. The metadata-guided approach facilitates structural and semantic interoperability, ultimately leading to enhanced data reusability and scientific rigor.

Results
The authors curated and deposited retrospective data from 10 large, NIH-funded sleep cohort studies, including several from the Trans-Omics for Precision Medicine (TOPMed) program, into the NSRR. The NSRR currently contains data on 26 808 subjects and 31 166 signal files in European Data Format. Launched in April 2014, over 3000 registered users have downloaded over 130 terabytes of data.

Conclusions
The NSRR offers a use case and an example for creating a full-fledged data commons. It provides a single point of access to analysis-ready physiological signals from polysomnography obtained from multiple sources, and a wide variety of clinical data to facilitate sleep research.
Breast Cancer Characteristics in Middle Eastern Women Immigrants Compared With Non-Hispanic White Women in California
Authors: Ziadeh Clara , Ziogas Argyrios , Jiang Luohua , Anton-Culver Hoda 
Published: April 2018

AbstractBackgroundEmerging evidence has indicated that Middle Eastern (ME) immigrants might be more likely to be diagnosed with breast cancer at advanced stage, yet have better overall survival than nonimmigrant non-Hispanic whites (NHW). This study aims to analyze the association between ME immigration status and breast cancer stage at diagnosis and survival.MethodsUsing the California Cancer Registry, a total of 343 876 women diagnosed with primary in situ or invasive breast cancers were identified during 1988–2013. Multinomial logistic regression models were fitted to evaluate the risk of in situ and nonlocalized breast cancer stage in comparison with localized breast cancer among first-generation ME immigrants, second- or subsequent-generation ME immigrants, and NHW. Cox proportional hazard models were applied to calculate hazard ratios (HRs) with their 95% confidence intervals (CIs) for breast cancer mortality among the three population groups with invasive primary breast cancer.ResultsFirst-generation ME immigrants had higher odds of being diagnosed with a nonlocalized stage (vs localized) than NHW (odds ratio [OR] = 1.17, 95% CI = 1.09 to 1.26). Second- or subsequent-generation ME immigrants also had higher odds of being diagnosed with a nonlocalized stage (vs localized) than NHW (OR = 1.31, 95% CI = 1.20 to 1.43). First-generation ME immigrants were 11% less likely to die from breast cancer than NHW (HR = 0.89, 95% CI = 0.82 to 0.97).ConclusionsFirst-generation ME immigrants had higher breast cancer survival despite being diagnosed at a nonlocalized breast cancer stage at diagnosis when compared with NHW. Screening interventions tailored to this ME immigrant group need to be implemented.
The Origins and Dynamics of Export Superstars
Authors: Freund Caroline , Pierola Martha Denisse 
Published: April 2018

Abstract
Export superstars are important for export growth and diversification and are typically born large. Firm-level data on manufacturing trade from 32 developing countries show that the top five exporters account for on average nearly one-third of exports, 47 percent of export growth, and a third of the growth due to export diversification over a five-year period. Within countries and industries, export growth is positively correlated with the share of exports in the top five firms. Most of the top five exporters were already large five (or eight) years ago or are new firms; it is rare for these export superstars to emerge from the bottom half of the distribution of firm sizes. For countries where detailed data exist, superstars are producers, not traders, and are primarily foreign owned.
The crosstalk between hematopoietic stem cells and their niches
Authors: Durand Charles , Charbord Pierre , Jaffredo Thierry 
Published: April 2018

Purpose of review
Hematopoietic stem cells (HSCs) reside in specific microenvironments also called niches that regulate HSC functions. Understanding the molecular and cellular mechanisms involved in the crosstalk between HSCs and niche cells is a major issue in stem cell biology and regenerative medicine. The purpose of this review is to discuss recent advances in this field with particular emphasis on the transcriptional landscape of HSC niche cells and the roles of extracellular vesicles (EVs) in the dialog between HSCs and their microenvironments.

Recent findings
The development of high-throughput technologies combined with computational methods has considerably improved our knowledge on the molecular identity of HSC niche cells. Accumulating evidence strongly suggest that the dialog between HSCs and their niches is bidirectional and that EVs play an important role in this process.

Summary
These advances bring a unique conceptual and methodological framework for understanding the molecular complexity of the HSC niche and identifying novel HSC regulators. They are also promising for exploring the reciprocal influence of HSCs on niche cells and delivering specific molecules to HSCs in regenerative medicine.
The Potential Diagnostic Accuracy of Autopsy Lung Weights, Lung-Heart Ratio, and Lung-Body Ratio in Drowning Deaths
Authors: Tse Rexson , Garland Jack , Kesha Kilak , Morrow Paul , Lam Leo , Elstub Hannah , Cala Allan , Spark Amy , Palmiere Cristian , Stables Simon 
Published: April 2018

Abstract
Lung weights are often increased in drowning deaths as well as in other types of deaths. Lung weights may also vary with age, sex, and body weight. A variety of methods have been proposed to utilize lung weight data to assist with the diagnosis of drowning. The present study compared lung weight, lung-heart ratio (LH), and lung-body ratio (LB) between 50 consecutive drowning and 50 nonimmersion deaths in order to assess the accuracy in diagnosing drowning. Analysis revealed both LH and LB to be statistically higher in drowning deaths (P < 0.05), with LB being the most robust measurement. However, the overall diagnostic accuracies of lung weight, LH, and LB were poor to fair, and should therefore be used only in conjunction with the other diagnostic criteria.
Facebook Facts: Breast Reconstruction Patient-Reported Outcomes Using Social Media
Authors: Tang Sherry Y. Q. , Israel Jacqueline S. , Poore Samuel O. , Afifi Ahmed M. 
Published: April 2018

Background:
Social media are used for information sharing among patients with similar health conditions, and analysis of social media activity could inform clinical decision-making. The aim of this study was to use Facebook to evaluate a cohort of individuals’ perceptions of and satisfaction with breast reconstruction.

Methods:
In this observational study, the authors collected and analyzed posts pertaining to autologous and implant-based breast reconstruction from active Facebook groups. Patient satisfaction data were categorized, and a thematic analysis of posts was conducted. Qualitative posts were grouped based on common themes and quantitatively compared using frequency and chi-square analysis.

Results:
The authors evaluated 500 posts from two Facebook groups. Two hundred sixty-four posts referenced deep inferior epigastric perforator (DIEP) flap reconstruction and 117 were related to implant-based reconstruction. Among individuals referencing DIEP flap reconstruction, 52 percent were satisfied, compared with 20 percent of individuals who referenced satisfaction with implant-based reconstruction (p < 0.0001). Individuals posting about DIEP flaps reported a higher rate of unexpected side effects (p < 0.001) and numbness (p = 0.004). When referencing implant-based reconstruction, individuals reported significantly higher rates of infection, contracture, and implant failure (p < 0.001).

Conclusions:
Based on the authors’ review of social media activity, individuals undergoing DIEP flap breast reconstruction expressed relatively high individual satisfaction despite difficult postoperative recovery. Individuals who referenced implant-based reconstruction mentioned infection and implant failure, leading to high rates of dissatisfaction. Social media appear to provide informational and emotional support to patients. Plastic surgeons can use social media to gather unbiased information of patients’ experience to inform clinical conversation and guide clinical practice.
Facial Fractures: Pearls and Perspectives
Authors: Chaudhry Obaid , Isakson Matthew , Franklin Adam , Maqusi Suhair , El Amm Christian 
Published: April 2018

Learning Objectives:
After studying this article, the participant should be able to: 1. Describe the A-frame configuration of anterior facial buttresses, recognize the importance of restoring anterior projection in frontal sinus fractures, and describe an alternative design and donor site of pericranial flaps in frontal sinus fractures. 2. Describe the symptoms and cause of pseudo-Brown syndrome, describe the anatomy and placement of a buttress-spanning plate in nasoorbitoethmoid fractures, and identify appropriate nasal support alternatives for nasoorbitoethmoid fractures. 3. Describe the benefits and disadvantages of different lower lid approaches to the orbital floor and inferior rim, identify late exophthalmos as a complication of reconstructing the orbital floor with nonporous alloplast, and select implant type and size for correction of secondary enophthalmos. 4. Describe closed reduction of low-energy zygomatic body fractures with the Gillies approach and identify situations where internal fixation may be unnecessary, identify situations where plating the inferior orbital rim may be avoided, and select fixation points for osteosynthesis of uncomplicated displaced zygomatic fractures. 5. Understand indications and complications of use for intermaxillary screw systems, understand sequencing panfacial fractures, describe the sulcular approach to mandible fractures, and describe principles and techniques of facial reconstruction after self-inflicted firearm injuries.

Summary:
Treating patients with facial trauma remains a core component of plastic surgery and a significant part of the value of a plastic surgeon to a health system.
Human Cytomegalovirus Immediate-Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus
Authors: Wu Cong-Cong , Jiang Xuan , Wang Xian-Zhang , Liu Xi-Juan , Li Xiao-Jun , Yang Bo , Ye Han-Qing , Harwardt Thomas , Jiang Man , Xia Hui-Min , Wang Wei , Britt William J. , Paulus Christina , Nevels Michael , Luo Min-Hua 
Published: April 2018

ABSTRACTThe mechanisms underlying neurodevelopmental damage caused by virus infections remain poorly defined. Congenital human cytomegalovirus (HCMV) infection is the leading cause of fetal brain development disorders. Previous work has linked HCMV to perturbations of neural cell fate, including premature differentiation of neural progenitor cells (NPCs). Here we show that HCMV infection of NPCs results in the loss of the SOX2 protein, a key pluripotency-associated transcription factor. SOX2 depletion maps to the HCMV major immediate-early (IE) transcription unit and is individually mediated by the IE1 and IE2 proteins. IE1 causes SOX2 down-regulation by promoting the nuclear accumulation and inhibiting the phosphorylation of STAT3, a transcriptional activator of SOX2 expression. Deranged signaling resulting in depletion of a critical stem cell protein is an unanticipated mechanism by which the viral major IE proteins may contribute to brain development disorders caused by congenital HCMV infection.IMPORTANCEHuman cytomegalovirus (HCMV) infections are a leading cause of brain damage, hearing loss and other neurological disabilities in children. We report that the HCMV proteins known as IE1 and IE2 target expression of human SOX2, a central pluripotency-associated transcription factor that governs neural progenitor cell (NPC) fate and is required for normal brain development. Both during HCMV infection and when expressed alone, IE1 causes the loss of SOX2 from NPCs. IE1 mediates SOX2 depletion by targeting STAT3, a critical upstream regulator of SOX2 expression. Our findings reveal an unanticipated mechanism by which a common virus may cause damage to the developing nervous system and suggest novel targets for medical intervention.
MLL1 minimal catalytic complex is a dynamic conformational ensemble susceptible to pharmacological allosteric disruption
Authors: Kaustov Lilia , Lemak Alexander , Wu Hong , Faini Marco , Houliston Scott , Fan Lixin , Fang Xianyang , Zeng Hong , Duan Shili , Allali-Hassani Abdellah , Vedadi Masoud , Aebersold Ruedi , Wang Yunxing , Arrowsmith Cheryl H. 
Published: April 2018

ABSTRACTHistone H3K4 methylation is an epigenetic mark associated with actively transcribed genes. This modification is catalyzed by the mixed lineage leukaemia (MLL) family of histone methyltransferases including MLL1, MLL2, MLL3, MLL4, SET1A and SET1B. Catalytic activity of MLL proteins is dependent on interactions with additional conserved proteins but the structural basis for subunit assembly and the mechanism of regulation is not well understood. We used a hybrid methods approach to study the assembly and biochemical function of the minimally active MLL1 complex (MLL1, WDR5 and RbBP5). A combination of small angle X-ray scattering (SAXS), cross-linking mass spectrometry (XL-MS), NMR spectroscopy, and computational modeling were used to generate a dynamic ensemble model in which subunits are assembled via multiple weak interaction sites. We identified a new interaction site between the MLL1 SET domain and the WD40 repeat domain of RbBP5, and demonstrate the susceptibility of the catalytic function of the complex to disruption of individual interaction sites.
Mitochondrial ubiquinone-mediated longevity is marked by reduced cytoplasmic protein translation
Authors: Molenaars Marte , Janssens Georges E. , Santermans Toon , Lezzerini Marco , Jelier Rob , MacInnes Alyson W. , Houtkooper Riekelt H. 
Published: April 2018

AbstractMutations in theclk-1gene impair mitochondrial ubiquinone biosynthesis and extend the lifespan ofC. elegans.We demonstrate here that this life extension is linked to the repression of cytoplasmic protein translation.Clk-1mutations inhibit polyribosome formation similarly todaf-2mutations that dampen insulin signaling. Comparisons of total versus polysomal RNAs inclk-1mutants reveal a reduction in the translational efficiencies of mRNAs coding for elements of the translation machinery and an increase in those coding for the oxidative phosphorylation and autophagy pathways. Knocking down the transcription initiation factor TAF-4, a protein that becomes sequestered in the cytoplasm during early embryogenesis to induce transcriptional silencing, ameliorates theclk-1inhibition of polyribosome formation. These results underscore a prominent role for the repression of cytoplasmic protein translation in eukaryotic lifespan extension, and suggest that mutations impairing mitochondrial function are able to exploit this repression similarly to reductions of insulin signaling. Moreover, this report reveals an unexpected role for TAF-4 as a repressor of polyribosome formation when ubiquinone biosynthesis is compromised.
The Identification Of Cortical Pyramidal Neurons Using A Rpp Based Algorithm
Authors: Kolezeva Yelena 
Published: April 2018

AbstractAppropriately classifying neuronal subgroups is critical to numerous downstream procedures in several disciplines of biomedical research. The cortical pyramidal neuron characterization technology has achieved rapid development in recent years. However, capturing true neuronal features for accurate pyramidal neuron characterization and segmentation has remained elusive. In the current study, a novel global preserving estimate algorithm is used to capture the non-linearity in the features of cortical pyramidal neuron after Factor Algorithm. Our results provide evidence for the effective integration of the original linear and nonlinear neuronal features and achieves better characterization performance on multiple cortical pyramidal neuron databases through array matching.
Wanting to change the world, is it too much of a good thing? How sustainable orientation shapes entrepreneurial behaviour
Authors: St-Jean Etienne , Labelle François 
Published: April 2018

Purpose
When pursuing a sustainable orientation (SO), entrepreneurs can resolve environmental and social problems and act as change agents by pursuing opportunities related to market failures. While many studies focus on entrepreneurial intention, very few try to explain entrepreneurial behaviour. The purpose of this paper is to highlight the circumstances under which people could be led to become sustainable entrepreneurs. It examines the effect of SO, as well as the entrepreneurial motivation to change society as key drivers of entrepreneurial behaviour.

Design/methodology/approach
The hypotheses were tested in three waves (six-month interval) on a sample of 197 university students that are neither entrepreneurs, nor involved in any entrepreneurial processes. The authors measured entrepreneurial behaviour as a dependent variable and used subjective norms towards entrepreneurship, entrepreneurial self-efficacy, entrepreneurial attitude as well as entrepreneurial motivation and SO as independent variables.

Findings
Contrary to the expectations, sustainability orientation has a negative impact on entrepreneurial action. However, individuals who think that entrepreneurship can change society (instrumentality) exhibit higher entrepreneurial action. Furthermore, this belief positively moderates the negative impact of SO on entrepreneurial action. In other words, if someone thinks that entrepreneurship can change the world, not only he/she is more inclined to engage in entrepreneurial actions but their values of SO will not decrease their entrepreneurial action.

Research limitations/implications
A longer timeframe of longitudinal research is needed to overcome the limitation regarding the assessment of entrepreneurial action.

Practical implications
As a practical implication, educators who want to engage their institution as an engine of change towards sustainable development could highlight cases of sustainable businesses where profits, environmental and social issues were not neglected to improve the perceived feasibility and thus, entrepreneurial action.

Originality/value
Results demonstrate the negative effect of SO on entrepreneurship as a career choice, but not for those who believe that they can change society through this mean. This research highlights the relevance of Socio Cognitive Career Theory in the field of entrepreneurship, especially the neglected effect of outcome expectations on entrepreneurship as a career choice.
Collaborative consumption: the role of familiarity and trust among Millennials
Authors: Mittendorf Christoph 
Published: April 2018

PurposeThis paper aims to focus on online hospitality platforms in the collaborative consumption environment. In particular, this paper investigates the impact of trust on the obtainers’ intentions to “inquire about accommodations” and to “request a booking” on Airbnb.com.Design/methodology/approachThis paper takes the perspective of a potential renter, respectively, obtainer and adopts Gefen’s (2000) research model, which incorporates familiarity and trust in the e-commerce industry. In this regard, the paper extends the work on two-sided markets of Mittendorf (2016-2017). To verify the modified research model, a survey was conducted, gathering results from over 426 participants of which 255 valid responses from the Millennials generation were obtained. This paper uses covariance-based structural equation modeling to analyze both measurement and structural relationships regarding the interaction framework.FindingsThe results show empirical evidence that both “trust in the intermediary” and “trust in providers” are decisive for the obtainers’ intentions on the online platform. In this regard, this paper advances the understanding of the collaborative consumption mechanisms by adapting trust literature to validate the obtainers’ intentions on contemporary collaborative consumption platforms.Research limitations/implicationsWhile the unit of analysis of prior research comprises the general intention to share, this paper empirically validates a more deliberate decision of user intentions by focusing on the intention to inquire about accommodations (no registration necessary) and the intention to request a booking (registration necessary). However, this study is dependent on one setting and it is still unclear whether the results are generalizable to other collaborative consumption setups.Originality/valueThis paper is in line with the work of Mittendorf (2016-2017), thus, it uses a sophisticated statistical approach to analyze trust in the collaborative consumption environment, such as confirmatory factor analysis and structural equation modeling.
Situational relevance of music information modes
Authors: Rousi Antti Mikael , Savolainen Reijo , Harviainen Maaria , Vakkari Pertti 
Published: April 2018

PurposeThe purpose of this paper is to elaborate the picture of situational relevance of music information from a performing musician’s point of view by delving into its diverse layers within the context of Doctor of Music students’ information seeking.Design/methodology/approachMusic-related information is approached through six modes that categorize music information sources based on their levels of abstraction. Situational relevance of the modes of music information is examined in relation to the situational requirements of accomplishing a dissertation on music task consisting of both a series of concerts and a written thesis. The empirical material was collected by interviewing Finnish doctoral students in the field of music performance.FindingsA set of situational relevance types related to each mode of music information were identified. As a whole, the differences between the perceived importance of the modes varied a little.Research limitations/implicationsThe goal of the present paper is not to create a generalizable list of situational relevance types suggested by modes of music information, but to show that the modes may suggest diverse situational relevance types of their own when evaluated by performing musicians.Originality/valueThe present paper provides a rare account on performing musicians’ vocational and school-related information seeking. For studies of music information retrieval, the present paper offers new contextual facets explaining why diverse music information could be relevant to musicians. For studies of music-related information seeking, the present study offers new insights on why performing musicians have information needs regarding certain types of music information sources.