bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Moral-Political Economy of the Spanish Empire in Practice
Authors: McClure Julia 
Published: November 2024

Abstract
This final chapter examines how the moral-political economy of the Spanish Empire operated in practice. It looks at the different institutions of hospitals and confraternities, the legal ecology of petitioning, and other strategies of welfare provision. It examines how the market and its redistributive function were conceptualised and regulated within the broader context of the moral-political economy. It examines the contemporary discussions on price fixing and just price. It also explores how the sovereign mobilised imperial capital to meet constitutional commitments to provide welfare and justice. It shows how the legal and institutional frameworks of the moral-political economy of the Spanish Empire were not only channels of top-down governance and discipline but also provided the infrastructure for imperial subjects to develop and articulate their agency within the newly emerging imperial context. Through focusing on moral discourses of poverty and articulations of moral-political obligations to the poor, the chapter shows how the moral, political, and economic realms were entangled, the significance of constitutional arrangements, and the negotiated nature of sovereignty.
Exploring the association between alcohol consumption and androgenic alopecia: a systematic review and meta-analysis
Authors: Yang Won Jin , Lee Jae Yong , Ko Dai Sik , Son Eunjeong , Shin Kihyuk , Kim Won Kyu , Kim Kihun , Kim Yun Hak 
Published: November 2024

Abstract

Aims
Androgenetic alopecia (AGA) is widely recognized as the most common form of hair loss and can significantly affect individuals’ quality of life. The association between alcohol consumption and AGA remains uncertain and controversial. Our primary objective is to investigate the relationship between alcohol consumption and AGA.

Methods
We identified studies from multiple databases, including Embase, MEDLINE, ScienceDirect, Scopus, and Web of Science, up to March 2024. For alcohol consumption, we included studies where it was defined as a categorical variable, such as Yes/No or classified by grams. For AGA, only cases that were clinically diagnosed were included. Odds ratios (ORs) and their corresponding 95% confidence intervals were extracted from the included studies. Subgroup analyses were conducted, considering factors such as gender and study design.

Results
Our findings indicated that individuals who consume alcohol had an OR of AGA compared to those who do not drink alcohol (OR, 1.40; 95% CI: .95–2.06; k = 6; I2 = 77%). In the subgroup analysis focusing on men, an OR for alopecia was observed (OR, 1.31; 95% CI: .85–2.01; k = 4; I2 = 78%). Additionally, a subgroup analysis based on study design revealed ORs of 1.93 (95% CI: 1.32–2.82; k = 3; I2 = 47%) for cross-sectional studies, and 1.69 (95% CI: 1.33–2.14; k = 2; I2 = 0%) for case–control studies.

Conclusions
Our results suggest that the effect of alcohol consumption on AGA may be less than initially assumed. Future research will require large, carefully planned cohort studies that incorporate standardized diagnostic criteria to provide more definitive insights.

Systematic review registration
CRD42022303374.
Refined surface area determination of graphene oxide using methylene blue as a probe molecule: a comparative approach
Authors: Ortiz-Anaya Israel , Nishina Yuta 
Published: November 2024

Abstract
In this research, we explored the effectiveness of the methylene blue adsorption method as an alternative approach for determining the specific surface area of graphene oxide. Initially, through a comparative analysis with reference activated carbon, we identified the limitations of utilizing N2 physisorption for specific surface area determination of graphene oxide. Our findings revealed that the standard pretreatment process (heating under vacuum) before N2 physisorption led to damage to the surface oxygen groups on graphene oxide, and the measured surface areas (43 m2/g) do not accurately represent the entire surface area. To optimize methylene blue coverage on graphene oxide, we conducted adsorption equilibrium experiments, focusing on controlling temperature and pH. The pH was significantly important in regulating the coverage of methylene blue. Under the optimized methylene blue adsorption conditions, the specific surface area of graphene oxide was 1,555 m2/g. Our assumptions regarding specific surface area calculations were supported by structural characterization of samples with varying methylene blue uptakes. The results confirmed a uniform coverage of methylene blue on graphene oxide by scanning electron microscopy and energy dispersive X-ray, X-ray diffraction, and atomic force microscopy.
Clearwater Drive: and other essays from the kitchen scholar
Authors: Jones Staci L , Jones Hattie Belle 
Published: November 2024

Abstract
This study employs Black feminist autoethnography (BFA) to examine knowledge hierarchies and the concept of organic intellectualism. This work repositions Black grandmothers as central figures in knowledge production by shifting the understanding of Black grandmotherhood from a traditionally narrow framework of wisdom to a broader, more authoritative realm of scholarship. Drawing on Ula Taylor’s concept of the “Street Stroller” and Paula Marshall’s “Kitchen Poet,” this article introduces the notion of the “Kitchen Scholar.” This work is part of a larger project.
How the bourgeoisie’s quest for status placed blame for poverty on the poor
Authors: Wisman Jon D 
Published: November 2024

Abstract
From the rise of the state to the emergence of capitalism, the poor were seldom blamed for their poverty. Because everyone was born into essentially unchangeable status roles, legitimated by religions and a static understanding of the social world, they could take neither credit for their good economic fortune nor blame for their privation. Most traditional religions insisted that the well-off must be charitable to the poor. This changed with the rise of capitalism and the ideology that legitimated its institutions and practices. Following upon the works of Max Weber and Richard Tawney, the role of Protestantism in generating an ideology that blames the poor for their abject condition has been widely acknowledged. What has been less appreciated is that this ideology has its roots in a new bourgeois class’s struggle for respectability and social status and that this struggle was a principal force fuelling Protestantism’s doctrinal character and success. This ideology depicted the success of the bourgeoisie as the result of virtuous behaviour and the misery of the poor as a consequence of their moral failings. Secular political and economic thought that arose alongside Protestantism also expressed the attitudes and practices of the emerging bourgeoisie, equally blaming the poor for their poverty. Social respect is essential for self-respect, both of which the bourgeoisie realized. Doing so set in motion forces delegitimating ascriptive status. However, it did so at the cruel cost of further debasing the social condition of the poor, depriving them of social- and self-respect.
Digital Images Translating Climate Justice Online to inspire Transformative Ecological Visions of World Order from the Margins
Authors: Doerr Nicole 
Published: November 2024

Abstract
This paper aims to study alternative visions of the world as they emerge creatively through digital media storytelling about floods, forest fires, and consequences of climate change that emerge within transnational climate justice activist networks and their digital media practices of translation and visual storytelling. Focusing on intersectional digital media practices among Fridays for Future (FFF) activists in Germany, it highlights the importance of marginalized voices and their transnational visions of world order and affective connections of solidarity that contest established world climate politics as insufficient. I conceive of questions of cultural and political translation as at the heart of understanding how critical voices from the margin become visible within broader, transnational public spaces due to intersectional (digital) media debates and public deliberation about climate change. I focus on the FFF movement in Germany and the visual practices of online media activists in translating perceived marginalized voices and political visions toward the spotlight of digital conversation within FFF Germany’s joint (trans)national, publicly accessible online spaces. Findings discuss how FFF alternative Telegram channels practice intersectional storytelling of floods, earth, and ecological transformation to make visible the critical agency of activists from the most affected peoples and communities engaged in protesting against extractivism and protecting nature in the Global South.
Safety, tolerability and pharmacokinetics of subcutaneous meropenem as an alternative to intravenous administration
Authors: Murray Fionnuala , Yoo Okhee , Brophy-Williams Samuel , Rawlins Matthew , Wallis Steven C , Roberts Jason A , Raby Edward , Salman Sam , Manning Laurens 
Published: November 2024

Abstract

Background
Subcutaneous delivery of antibiotics is a practical alternative to IV administration. Meropenem is commonly used to treat infections caused by resistant Gram-negative organisms.

Methods
This was a prospective, crossover self-controlled study in 11 stable inpatients established on meropenem. Participants received a single dose of subcutaneous meropenem, in 50 mL normal saline via gravity feed. Venous blood sampling was performed at baseline, 0.5, 1, 2, 4 and 8 h following the subcutaneous and IV doses. Antibiotic concentrations were measured using UPLC-MS/MS. Pharmacokinetic data were analysed using a non-linear mixed-effects modelling approach. Pain scores and infusion site reactions (oedema/erythema) were assessed.

Results
Subcutaneous meropenem was well tolerated. The bioavailability of subcutaneous administration was 81.5% (95% CI 71.6%–93.2%). Increasing BMI was associated with slower absorption from subcutaneous tissue. Compared with IV, subcutaneous administration resulted in lower peak and higher trough concentrations. Despite the lower bioavailability observed, the PTA for free drug concentrations greater than the MIC for more than 40% of the time between doses was higher for subcutaneous than IV administration at MIC values between 0.03 and 8 mg/L. Simulated subcutaneous doses of 1.5 g twice daily, or 3 g continuous 24 h infusion had improved PTA relative to standard IV dosing of 1 g three times daily.

Conclusions
Subcutaneous meropenem appears to be well tolerated and has a favourable pharmacokinetic profile. Either 1.5 g twice daily or 3 g as a 24 h subcutaneous infusion could be considered for future evaluation.
Clinical outcomes following acute sore throat assessment at community pharmacy versus general practice: a retrospective, longitudinal, data linkage study
Authors: Mantzourani Efi , Ahmed Haroon , Bethel Jackie , Turner Samantha , Akbari Ashley , Evans Andrew , Prettyjohns Matthew , John Gareth , Gunnarsson Ronny , Cannings-John Rebecca 
Published: November 2024

Abstract

Background
To date, no research has compared longer-term outcomes (antibiotic provision; re-consultations; hospital admissions for quinsy; cost-effectiveness) following presentation with acute sore throat at general practice (GP) versus newer, pharmacy-led services.

Methods
A retrospective, longitudinal cohort study of sore throat consultations between 1 November 2018 and 28 February 2020 either with the Wales pharmacy-led sore throat test and treat (STTT) service or with a healthcare professional at GP. Individual-level pharmacy consultation data from the national Choose Pharmacy IT application were securely uploaded to the Secure Anonymised Information Linkage Databank and linked to routinely collected, anonymized, population-scale, individual-level, anonymized health and administrative data.

Results
Of 72 736 index consultations, 6495 (8.9%) were with STTT and 66 241 (91.1%) with GP. Antibiotic provision at the index consultation was 1382 (21%) with STTT and 25 506 (39%) with GP [adjusted odds ratio (AOR), 0.30; 95% CI, 0.27 to 0.32]. Antibiotic provision within 28 days of index occurred in 1820 (28%) STTT and 26 369 (40%) GP consultations (AOR, 0.44; 95% CI, 0.41 to 0.47). GP re-consultation rate within 28 days of index date was 21% (n = 1389) with STTT compared with 7.4% (n = 4916) with GP (AOR, 3.8; 95% CI, 3.5 to 4.1). Coding limitations may lead to overestimates of GP re-consultations rates in the STTT group. Hospital admissions for quinsy were rare in both STTT (n = 20, 0.31%) and GP (n = 274, 0.41%) (AOR, 0.68; 95% CI, 0.43 to 1.1). STTT was less costly than consultation with GP.

Conclusions
The pharmacy-led STTT service is safe, cost-effective, and contributes to antimicrobial stewardship.
CEO deaths and credit relationships: evidence from an emerging market
Authors: Natividad Gabriel 
Published: November 2024

Abstract
In a sample representing 40% of Peru’s formal economy, firms shocked by the death of their chief executive officer experience lower sales and a higher probability of exit, lower borrowing amounts and credit performance, and a reduced number of lenders compared with very similar firms. Existing lenders bear the negative consequences. Monthly risk assessments by lenders worsen immediately after the death events. The negative effects are observed across various firm sizes, while industry characteristics, incorporation, and family ties are relevant dimensions of heterogeneity. Lenders with a longer relationship history, and those less constrained for loan-making, protect themselves by introducing collateral clauses. (JEL D25, G30, L25).
The mOTUs online database provides web-accessible genomic context to taxonomic profiling of microbial communities
Authors: Dmitrijeva Marija , Ruscheweyh Hans-Joachim , Feer Lilith , Li Kang , Miravet-Verde Samuel , Sintsova Anna , Mende Daniel R , Zeller Georg , Sunagawa Shinichi 
Published: November 2024

Abstract
Determining the taxonomic composition (taxonomic profiling) is a fundamental task in studying environmental and host-associated microbial communities. However, genome-resolved microbial diversity on Earth remains undersampled, and accessing the genomic context of taxa detected during taxonomic profiling remains a challenging task. Here, we present the mOTUs online database (mOTUs-db), which is consistent with and interfaces with the mOTUs taxonomic profiling tool. It comprises 2.83 million metagenome-assembled genomes (MAGs) and 919 090 single-cell and isolate genomes from 124 295 species-level taxonomic units. In addition to being one of the largest prokaryotic genome resources to date, all MAGs in the mOTUs-db were reconstructed de novo in 117 902 individual samples by abundance correlation of scaffolds across multiple samples for improved quality metrics. The database complements the Genome Taxonomy Database, with over 50% of its species-level taxonomic groups being unique. It also offers interactive querying, enabling users to explore and download genomes at various taxonomic levels. The mOTUs-db is accessible at https://motus-db.org.
dbPTM 2025 update: comprehensive integration of PTMs and proteomic data for advanced insights into cancer research
Authors: Chung Chia-Ru , Tang Yun , Chiu Yen-Peng , Li Shangfu , Hsieh Wen-Kai , Yao Lantian , Chiang Ying-Chih , Pang Yuxuan , Chen Guan-Ting , Chou Kai-Chen , Paik You Sheng , Tran Phuong Lam , Lin Cheng-Pei , Kao Yu-Min , Chen Yi-Jie , Chang Wen-Chi , Hsu Justin Bo-Kai , Horng Jorng-Tzong , Lee Tzong-Yi 
Published: November 2024

Abstract
Post-translational modifications (PTMs) are essential for modulating protein function and influencing stability, activity and signaling processes. The dbPTM 2025 update significantly expands the database to include over 2.79 million PTM sites, of which 2.243 million are experimentally validated from 48 databases and over 80 000 research articles. This version integrates proteomic data from 13 cancer types, with a particular focus on phosphoproteomic data and kinase activity profiles, allowing the exploration of personalized phosphorylation patterns in tumor samples. Integrating kinase–substrate phosphorylations with E3 ligase–substrate interactions, dbPTM 2025 provides a detailed map of PTM regulatory networks, offering insights into cancer-specific post-translational regulations. This update also includes advanced search capabilities, enabling users to efficiently query PTM data across species, PTM types and modified residues. The platform’s new features—interactive visualization tools and streamlined data downloads—allow researchers to access and analyze PTM data easily. dbPTM 2025 also enhances functional annotations, regulatory networks and disease associations, broadening its application for cancer research and the study of disease-associated PTMs. Through these enhancements, dbPTM 2025 is a comprehensive, user-friendly resource, facilitating the study of PTMs and their roles in cancer research. The database is now freely accessible at https://biomics.lab.nycu.edu.tw/dbPTM/.
jPOST environment accelerates the reuse and reanalysis of public proteome mass spectrometry data
Authors: Okuda Shujiro , Yoshizawa Akiyasu C , Kobayashi Daiki , Takahashi Yushi , Watanabe Yu , Moriya Yuki , Hatano Atsushi , Takami Tomoyo , Matsumoto Masaki , Araki Norie , Tabata Tsuyoshi , Iwasaki Mio , Sugiyama Naoyuki , Kodera Yoshio , Tanaka Satoshi , Goto Susumu , Kawano Shin , Ishihama Yasushi 
Published: November 2024

Abstract
jPOST (https://jpostdb.org/) comprises jPOSTrepo (https://repository.jpostdb.org/) (over 2000 projects), a repository for proteome mass spectrometry data, the reanalysis of raw proteome data based on a standardised protocol using UniScore, and jPOSTdb (https://globe.jpostdb.org/) (over 600 datasets), a database that integrates the reanalysed data. The jPOST reanalysis protocol rescores MS/MS spectra using a new scale, UniScore, to evaluate the extent to which the spectral peaks correspond to the amino acid sequences identified by search engines. However, the metadata registered in the repository database is insufficient for conducting the reanalysis. To address this issue, the Japanese Proteomics Society launched a data journal, the Journal of Proteome Data and Methods (JPDM), which accepts data descriptor articles detailing metadata that can be reanalysed. Within jPOST, raw proteome data is reanalysed based on the metadata described in the JPDM data descriptor articles, utilising UniScore. The reanalysed data is deposited in jPOSTdb, and a link to the JPDM articles is added to jPOSTrepo. These reanalysis accelerations within the jPOST environment will promote FAIR data principles and open science.
CORUM in 2024: protein complexes as drug targets
Authors: Steinkamp Ralph , Tsitsiridis George , Brauner Barbara , Montrone Corinna , Fobo Gisela , Frishman Goar , Avram Sorin , Oprea Tudor I , Ruepp Andreas 
Published: November 2024

Abstract
CORUM (https://mips.helmholtz-muenchen.de/corum/) is a public database that offers comprehensive information about mammalian protein complexes, including their subunits, functions and associations with human diseases. The newly released CORUM 5.0, encompassing 7193 protein complexes, is the largest dataset of manually curated mammalian protein complexes publicly available. This update represents the most significant upgrade to the database in &gt;15 years. At present, the molecular processes in cells that are influenced by drugs are only incompletely understood. In this latest release, we have begun systematically investigating the impact of drugs on protein complexes. Our studies are based on a dataset from DrugCentral comprising 725 protein drug targets with approved drugs and known mechanisms of action. To date, we have identified 1975 instances from the literature where a drug affects the formation and/or function of a protein complex. Numerous examples highlight the crucial role of understanding drug–protein complex relationships in drug efficacy. The expanded dataset and the inclusion of drug effects on protein complexes are expected to significantly enhance the utility and application potential of CORUM 5.0 in fields such as network medicine and pharmacological research.
Synthetic translational coupling element for multiplexed signal processing and cellular control
Authors: Goh Hyunseop , Choi Seungdo , Kim Jongmin 
Published: November 2024

Abstract
Repurposing natural systems to develop customized functions in biological systems is one of the main thrusts of synthetic biology. Translational coupling is a common phenomenon in diverse polycistronic operons for efficient allocation of limited genetic space and cellular resources. These beneficial features of translation coupling can provide exciting opportunities for creating novel synthetic biological devices. Here, we introduce a modular synthetic translational coupling element (synTCE) and integrate this design with de novo designed riboregulators, toehold switches. A systematic exploration of sequence domain variants for synTCEs led to the identification of critical design considerations for improving the system performance. Next, this design approach was seamlessly integrated into logic computations and applied to construct multi-output transcripts with well-defined stoichiometric control. This module was further applied to signaling cascades for combined signal transduction and multi-input/multi-output synthetic devices. Further, the synTCEs can precisely manipulate the N-terminal ends of output proteins, facilitating effective protein localization and cellular population control. Therefore, the synTCEs could enhance computational capability and applicability of riboregulators for reprogramming biological systems, leading to future applications in synthetic biology, metabolic engineering and biotechnology.