bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined local and systemic bleomycin administration in electrochemotherapy to reduce the number of treatment sessions
Authors: Maglietti Felipe , Tellado Matias , Olaiz Nahuel , Michinski Sebastian , Marshall Guillermo 
Published: April 2018

AbstractBackgroundElectrochemotherapy (ECT), a medical treatment widely used in human patients for tumor treatment, increases bleomycin toxicity by 1000 fold in the treated area with an objective response rate of around 80%. Despite its high response rate, there are still 20% of cases in which the patients are not responding. This could be ascribed to the fact that bleomycin, when administered systemically, is not reaching the whole tumor mass properly because of the characteristics of tumor vascularization, in which case local administration could cover areas that are unreachable by systemic administration.Patients and methodsWe propose combined bleomycin administration, both systemic and local, using companion animals as models. We selected 22 canine patients which failed to achieve a complete response after an ECT treatment session. Eleven underwent another standard ECT session (control group), while 11 received a combined local and systemic administration of bleomycin in the second treatment session.ResultsAccording to the WHO criteria, the response rates in the combined administration group were: complete response (CR) 54% (6), partial response (PR) 36% (4), stable disease (SD) 10% (1). In the control group, these were: CR 0% (0), PR 19% (2), SD 63% (7), progressive disease (PD) 18% (2). In the combined group 91% objective responses (CR+PR) were obtained. In the control group 19% objective responses were obtained. The difference in the response rate between the treatment groups was significant (p < 0.01).ConclusionsCombined local and systemic bleomycin administration was effective in previously to ECT non responding canine patients. The results indicate that this approach could be useful and effective in specific population of patients and reduce the number of treatment sessions needed to obtain an objective response.
Sustainable Development of the Mountain Territory of the Ukrainian Carpathians: Foreign Experience and Domestic Realities
Authors: Chervinska Inna , Chervinskyi Andrii 
Published: April 2018

The article describes the factors and indicators of sustainable development of mountain areas. The authors analyse the experience of foreign countries in the educational and socio-cultural activities of the inhabitants of the mountains, determine the prospects for its implementation in the mountainous regions of the Ukrainian Carpathians. The researches determine the ways and prospects of development of mountain territories of the Ukrainian Carpathians compare foreign experience of some European countries and the United States on sustainable development.
The purpose of the article is based on studying the experience of mountainous countries, identifying the leading factors influencing their sustainable development and revealing the prospects for their implementation in the mountainous regions of the Ukrainian Carpathians. In accordance with the purpose of the study, features of mountain areas were outlined, the factors that determine the specifics of their educational, ecological, economic and socio-cultural development are described. The authors analysed international experience of managing the development of mountain areas in order to determine the possibilities of its use in national practice
Regulation of Global Transcription in Escherichia coli by Rsd and 6S RNA
Authors: Lal Avantika , Krishna Sandeep , Seshasayee Aswin Sai Narain 
Published: April 2018

Abstract
In Escherichia coli, the sigma factor σ70 directs RNA polymerase to transcribe growth-related genes, while σ38 directs transcription of stress response genes during stationary phase. Two molecules hypothesized to regulate RNA polymerase are the protein Rsd, which binds to σ70, and the non-coding 6S RNA which binds to the RNA polymerase-σ70 holoenzyme. Despite multiple studies, the functions of Rsd and 6S RNA remain controversial. Here we use RNA-Seq in five phases of growth to elucidate their function on a genome-wide scale. We show that Rsd and 6S RNA facilitate σ38 activity throughout bacterial growth, while 6S RNA also regulates widely different genes depending upon growth phase. We discover novel interactions between 6S RNA and Rsd and show widespread expression changes in a strain lacking both regulators. Finally, we present a mathematical model of transcription which highlights the crosstalk between Rsd and 6S RNA as a crucial factor in controlling sigma factor competition and global gene expression.
Nykščio riešinio sąnario artrozės gydymas atvirąja sinovektomija su sąnario išvalymu: vėlyvųjų pooperacinių gydymo rezultatų įvertinimas
Authors: Tamulevičius Martynas , Minderis Mindaugas , Pajėda Andrius 
Published: April 2018

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Įvadas. Atlikta sisteminė mokslinės literatūros apžvalga parodė, kad gydant nykščio riešinio sąnario osteoartitą nė viena chirurginė metodika nėra reikšmingai pranašesnė. Straipsnyje siekiama įvertinti atvirosios sinovektomijos su sąnario išvalymu („debridementu“) vėlyvuosius pooperacinius gydymo rezultatus ir palyginti juos su kitų, dažnai taikomų metodikų, rezultatais.Metodai. Atlikta retrospektyvinė studija, kurioje įvertinta 19 pacientų (20 nykščių), sergančių II–IV stadijos nykščio riešinio sąnario osteoartritu. Visi pacientai operuoti vieno chirurgo, taikant atvirą sinovektomiją su sąnario išvalymu, kurios metu pašalinta išvešėjusi sinovija, kaulinės išaugos ir laisvieji kūnai.Pagal vidutinį pacientų stebėjimo laiką skiriamos dvi tiriamųjų grupės: iki 4,5 metų (N = 10) ir daugiau negu 4,5 metų (N = 9) po operacijos stebėti pacientai. Įvertintas pokytis skaitinėje skausmo skalėje, pooperacinė plaštakos funkcija (pincetinio ir šoninio gnybio jėga, priešpastatymo amplitudė, QuickDASH klausimyno įvertis), pooperacinė sąnario būklė (dviejų krypčių plaštakos rentgenogramos) ir trukmė iki susigrąžinto darbingumo. Gauti rezultatai lyginti su dažniausiai pasirenkamų gydymo metodų studijų rezultatais.Rezultatai. Nustatyta, kad visiems pacientams po operacijos statistiškai reikšmingai sumažėjo skausmo intensyvumas (kaip ir kitose studijose, kurių duomenys buvo lyginami). Visiško skausmo išnykimo procentas II grupėje reikšmingai nesiskyrė nuo rezultatų, pateikiamų kitose studijose. Reikšmingų skirtumų lyginant QuickDASH įverčius taip pat nenustatyta. Lyginant pincetinio ir šoninio gnybio jėgas, gauti panašūs arba aukštesni įverčiai.Populiariose gydymo metodikose, kurių rezultatai buvo lyginami su atlikto tyrimo duomenimis, minima pagrindinė komplikacija ­– delnakaulio proksimalizacija. Atliktame tyrime, įvertinus tiriamųjų pooperacines rentgenogramas, tokios komplikacijos nenustatyta. Tiriamieji grįžo į kasdienę savo veiklą vidutiniškai per tris mėnesius, o tai reikšmingai skyrėsi nuo kitų gydymo metodikų, kuriose taikoma fiksacija Kiršnerio vielomis ir ilgai trunkanti reabilitacija.Išvados. Atlikto tyrimo rezultatus palyginus su dažniausiai taikomų chirurginių metodikų rezultatais, vertinant plaštakos skausmą ir funkciją pacientų ilgojo stebėjimo laikotarpiu reikšmingų skirtumų nenustatyta. Tiriamiesiems rentgenografiškai diagnozuota palankesnė pooperacinė sąnario būklė, leidžianti pacientui greičiau susigrąžinti darbingumą. Dėl minėtų priežasčių atviroji sinovektomija su sąnario išvalymu galėtų būti pirmo pasirinkimo metodas gydant nykščio riešinio sąnario osteoartritą.
Grynoji ir dialoginė fenomenologija
Authors: Geniušas Saulius 
Published: April 2018

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Straipsnyje siekiama parodyti, kodėl reikia atmesti populiarią fenomenologijos sampratą, pagal kurią fenomenologija yra pirmąja asmens perspektyva paremta refleksija. Straipsnyje argumentuojama, kad tyrinėjimas gali būti įvardijamas kaip fenomenologinis huserliškąja prasme, jeigu ir tik jeigu jis yra paremtas trimis pamatiniais fenomenologiniais principais – epoché, fenomenologine redukcija ir eidetine variacija – suprantant juos kaip nepakeičiamus fenomenologinius principus, sudarančius grynosios fenomenologijos pamatą. Šie trys fenomenologiniai principai yra būtini, bet nepakankami: jie turi būti papildyti faktinės variacijos principu. Straipsnyje pristatoma pozicija, kad faktinės variacijos inkorporavimas į fenomenologinių tyrinėjimų lauką transformuoja grynąją fenomenologiją į dialoginę fenomenologiją.
Antimicrobial Activity of Some Synthetic Compounds on Fungi Associated with Post Harvest Rot of Red Pepper (Capsicum annum)
Authors: KOLAWOLE Matthew O. , ANIBIJUWON Ibikunle I. , ADETITUN David O. , BABATUNDE Shola K. , ANJORIN Efuntoye 
Published: April 2018

Rhizopus sp, Mucor sp, Collectotrichum capsici and Geotrichum candidum were isolated but pathogenic test revealed that Collectotrichum capsici and Geotrichum candidum were the most pathogenic of all the isolates. Ni2+ + Azo has the highest inhibitory effect, closely followed by Ni2+ + PAN while Copper (II) complex of Thiourea has the lowest inhibitory effect. However, 10mg/ml concentration proved to be the most effective when radial mycelial growth of the test fungi was measured. The inhibitory effects of each complex on the isolates increases with increase in incubation period. There is the feasibility of using synthetic
associated with the symptoms. The three synthetic compounds, Copper (II) complex of Thiourea, Ni2+ + compounds as preservatives for harvested red pepper.
Analysis of Several Popular Cultivars of Madagascar Periwinkle (<i>Catharanthus roseus</i> (L.) G. Don.) using Biochemical Markers
Authors: ANIEL KUMAR Owk , TATA Sape S. , PAVAN KUMAR Kancharla 
Published: April 2018

Band designs of esterase (EST), peroxidase (PO) and polyphenol oxidase (PPO) isozymes in several selected cultivars of Catharanthus roseus by using native polyacrylamide gel electrophoresis (PAGE) were investigated in this study. It was confirmed that cultivar differences in isozyme polymorphism can be revealed by applied electrophoretic patterns. Three isozyme systems produced a total of 16 bands with polymorphism ranged from 66.6-100%. Considering the patterns of isozyme variations in the five cultivars of Catharanthus roseus, it is evident that the cultivar ‘First kiss coral’ displayed crimson red petal with large white eye’ displayed demarked profiles of EST, PO and PPO isozymes than other cultivars. This is the first report on isozyme polymorphism in members of the Cathanarathus roseus (L.) G.
Don.
Ethan Kleinberg: Teoria da História como Fantologia
Authors: Ramos André Da Silva 
Published: April 2018

Ethan Kleinberg is Professor of History and Letters of Wesleyan University. He is the Director of the Center for Humanities and the Editor-in-Chief of History and Theory. His first book, Generation Existential: Heidegger’s Philosophy in France, 1927-1961, published by Cornell University Press, was awarded the 2006 Morris D. Forkosch prize for the best book in intellectual history, by the Journal of the History of Ideas. Recently, Professor Kleinberg co-edited with Ranjan Ghosh the volume Presence: Philosophy, History and Cultural Theory for the 21st Century, published by Cornell University Press as well. His book, Haunting History: For a Deconstructive Approach to the Past, will appear in the Meridian Series from Stanford University Press in Fall 2017. He is also finishing the book The Myth of Emmanuel Levinas, centered on the Talmudic Lectures that the French-Jewish philosopher presented in Paris between 1960 and 1990. I had the opportunity to conduct an interview with Professor Kleinberg in June 2016, when I was a Visiting Student Researcher in the Center for Humanities at Wesleyan University. We also took the advantage of the Second International Network for Theory of History conference (2nd INTH), that happened in Brazil at Ouro Preto from August 23 to August 26, to expand the interview.
Risk factors, clinico-epidemiological profile of tuberculosis among children attending a tertiary care hospital: a two year study
Authors: Tenali Ravikumar , Badri Naveen Kumar , Kandati Jithendra , Ponugoti Munilakshmi 
Published: April 2018

Background: TB remains as the one among the top 10 causes of death worldwide. In 2016, 10.4 million people fell ill with TB, and 1.7 million died from the disease with 0.4 million with HIV. At least 1 million children become ill with TB each year. Children represent about 10-11% of all TB cases. Having knowledge of the risk factors for tuberculosis infection in children is important to evaluate the level of ongoing transmission of infection and to help adapt activities within national TB control programs. The main objective is to study the risk factors and their association and variable clinical features in cases of pulmonary and extra pulmonary tuberculosis.Methods: The main objective is to study the risk factors and their association and variable clinical features in cases of pulmonary and extra pulmonary tuberculosis.Results: 98 cases of TB were confirmed out of total 628 with a prevalence of 17.07% in the study with 78 PTB cases and 20 EPTB. Females were more with male to female ratio of 0.7:1.5-9 years was the most common age group in the study. Statistically significant association was found between old history of ATT, HIV positivity, contact with an open case of TB and malnutrition (p value<0.05). TB meningitis was the most common EPTB (10/20 cases) followed by tuberculous lymphadenitis (5/20). 69.39% (68/98 cases) were smear positive, radiologically 59.18% of cases were positive and Tuberculin skin test was positive in 46.94%.Conclusions: Childhood tuberculosis is a neglected entity in developing countries due to underreporting and difficulties in diagnosis due to variable clinical picture in children. Hence epidemiological surveillance studies in children are required to determine the actual prevalence of pulmonary and extra pulmonary cases of tuberculosis. Increased efforts are required to isolate TB bacilli from body fluids to identify early the childhood cases and manage them to prevent disease burden in the community.
Effectiveness of a training workshop on perceptions and practice of interns in management of acute diarrheal diseases in children
Authors: Sindhu T. G. , Geeta M. G. , Geetha P. , Fiji M. D. 
Published: April 2018

Background: There is a perceived lack of competency of interns in managing common childhood conditions like acute diarrheal diseases (ADD). In the present system there is no formal training is given to the interns. Additional structured training programs during internship will help to improve their performance. This is of special importance in the context of current shift towards a competency based medical education (CBME). This study was conducted at a government medical College in North Kerala to find out the effect of a workshop on perceptions and practice of interns in management of acute diarrheal diseases in children.Methods: 15 interns posted in Paediatric department during July 2015 were administered a pre-test to assess their perceptions and practice about managing ADD by using short answer questions (SAQ), questionnaire and Objective Structured Clinical Examination (OSCE). After the pre-test a training workshop on management of ADD was conducted. The feedbacks were obtained. A post test was conducted 3 days later. The pre and post workshop scores were compared using student t test.Results: There was an improvement in knowledge, skills and self-perceived level of confidence of the interns in managing ADD in children after the workshop. Conclusions: A training workshop will improve the knowledge, skills and confidence of interns in managing a child presenting with acute diarrhoea.
The magnitude, determinants and barriers for physical activities among diabetic patients in Qassim area of Saudi Arabia
Authors: Aldukhayel Abdulrhman 
Published: April 2018

Background: To review the level of physical activity (PA) among adult diabetics and barriers to PA in this population.Methods: This survey was performed in 2017 and enrolled adult diabetics from primary health center of the National Guard in Qassim, Saudi Arabia. International Physical activity questionnaire was used to grade the level of PA. The three intensities of PA (walking, moderate and vigorous exercise), and number of days per week and hours per day were queried for each participant. Metabolic equivalent (MET), a proxy indicator of PA was calculated. Data were analyzed for associations to demographic and diabetes-related factors. Participants were queried on barriers to PA such as time, space, high cost, physical disability, preoccupation with other priorities and languor. Results: We interviewed 395 diabetic patients. The low and moderate levels of PA were noted for 320 (81%) and 75 (19%) participants respectively. None had a high level of PA. Gender (P=0.4), age (P=0.45), body mass index (P=0.66) were not associated to PA. Joint problems (43%), languor (35.2%) and family time (33.9%) were the main barriers that lowered PA. Conclusions: There was a low level of PA among diabetics in Qassim. Barriers to PA should be proactively addressed during patient counseling to improve PA in this population. Counseling direct towards increasing PA may mitigate the physically disabling complications of cardiovascular events among diabetics.
Preparing a change laboratory intervention: waste management in a University hospital
Authors: Cassandre Marcio Pascoal , Senger Carine Maria , Querol Marco Antonio Pereira 
Published: April 2018

Abstract: Researchers, interventionists and managers are challenged to plan an intervention for the development of an activity. To this purpose, it is necessary to understand and negotiate the object of the intervention with the participants. This task can be facilitated through the elaboration of a research scheme used as a planning and learning tool among interventionists and participants. This article presented an outline of such scheme for future application of a Change Laboratory (CL). This lab is considered a method to provide the development of the solid waste management activity in a university hospital in Paraná State, Brazil. The study shows the aspects to be explored to plan a CL in order to develop a new concept of this activity. It is a draft for the planning of these methodology sessions. Its preparation makes use of preliminary ethnographic data collected during the beginning of the investigative procedure foreseen by CL, seeking the current conflict historical understanding.Keywords: Activity Theory. Change Laboratory. Waste Management. University Hospital. Preparando uma intervenção do Laboratório de Mudança: a gestão dos resíduos de um hospital universitário Resumo: Pesquisadores, intervencionistas e gestores são desafiados a planejar uma intervenção visando ao desenvolvimento de uma atividade. Para tanto, faz-se necessário entender e negociar o objeto da intervenção com os participantes. Tal tarefa pode ser facilitada por meio da elaboração de um esquema usado como instrumento de planejamento e aprendizagem entre intervencionista e participantes. Neste artigo apresentou-se um esboço deste esquema para a aplicação futura de um Laboratório de Mudança (LM). Este laboratório é considerado um método para propiciar o desenvolvimento da atividade de gestão de resíduos sólidos em um hospital universitário do Paraná. O estudo mostra os aspectos a serem explorados para planejar um LM visando desenvolver um novo conceito dessa atividade. Trata-se de um rascunho para o planejamento das sessões dessa metodologia. Sua elaboração faz uso de dados etnográficos preliminares coletados durante o início do processo investigativo previsto pelo LM, buscando a compreensão histórica da atual situação do conflito.Palavras-chave: Teoria da Atividade. Laboratório de Mudança. Gestão de Resíduos. Hospital Universitário.
New Immigrant Health Professional’s Individual, Societal and Economic Impact of Ryerson University’s Internationally Trained Medical Doctors (ITMDs) Bridging Program: Results from a Pilot Bridge Training Program at the Chang School of Continuing Education
Authors: Bhuiyan Shafi U. 
Published: April 2018

Although Canada is home to a large number of internationally educated health professionals, their skills and experiences are grossly underutilized in the Canadian healthcare landscape. Barriers to medical practice are pervasive, and as a result the majority of internationally trained medical doctors (ITMDs) work in “survival” jobs significantly below their skill level. The pilot ITMD Bridging Program was developed to provide an alternative path for ITMDs by providing the skills and competencies required for non-licensed health sector employment, ultimately aiming to improve integration of ITMDs into the Canadian workforce. This secondary research evaluates the ITMD Bridging Program by assessing the impact of the program at both individual and societal levels.Qualitative and quantitative data were used to evaluate the individual and societal impact of the program. Secondary data from participants’ entry and exit surveys, as well as key informant interviews conducted with ITMDs upon program completion were used for the analysis. The economic impact of the program and its overall utility to the economy of Ontario were assessed through literature review and social rate of return analysis.ITMDs program participants reported substantial improvements in skills related each of the core courses including health research methods, health informatics and data management, fundamentals of project management, as well as healthcare professionals communication and leadership skills. ITMDs also perceived the program to be a viable option to address human potential waste, enhance the economy, develop individual capacity building, and alleviate frustrations associated with labour market exclusion. The program is also economically viable at the societal level, and represents a rate of return of 6.52%.The ITMD Bridging Program has demonstrated that providing non-licensed health sector employment is a viable option for policymakers to consider in their efforts to address the current brain waste in the Ontario healthcare sector. Bridging programs similar to the ITMD Bridging Program have the capacity to impact individual outcomes of ITMDs, the economic landscape in Ontario, and Canada at large.
A Traumatic Asphyxia After A Construction Accident
Authors: ÖZDEMİR Özlem , SAVRUN Atakan 
Published: April 2018

The traumatic asphyxia is
defined as cyanosis, petechiae on the face, neck, upper extremities and upper
parts of the thorax and subconjunctival haemorrhage, retinal edema due to blunt thoracic trauma. Traumatic
asphyxia is a rare syndrome. In cases of traumatic asphyxia,
different neurological symptoms can be seen to be proportional to the severity
of trauma. Treatment is conservative, but depends on the severity of
prognostic-related injuries. In this article, we present a case of traumatic
asphyxia syndrome in a 35 year old male patient who had a traumatic asphyxia
syndrome resulting from a construction accident. And in this context the
literature, diagnosis, treatment and prognosis were discussed.