bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity
Authors: Baars Matthijs , Douma Thera , Simeonov Dimitre R. , Myers Darienne R. , Banerjee Saikat , Kulhanek Kayla , Zwakenberg Susan , Baltissen Marijke P. , de Roock Sytze , van Wijk Femke , Vermeulen Michiel , Marson Alexander , Roose Jeroen P. , Vercoulen Yvonne 
Published: June 2019

AbstractRasGRP1 is a Ras guanine nucleotide exchange factor, and an essential regulator of lymphocyte receptor signaling. In mice, Rasgrp1 deletion results in defective T lymphocyte development. RASGRP1-deficient patients suffer from immune deficiency, and the RASGRP1 gene has been linked to autoimmunity. However, how RasGRP1 levels are regulated, and if RasGRP1 dosage alterations contribute to autoimmunity remains unknown. We demonstrate that diminished Rasgrp1 expression caused defective T lymphocyte selection in C57BL/6 mice, and that the severity of inflammatory disease inversely correlates with Rasgrp1 expression levels. In patients with autoimmunity, active inflammation correlated with decreased RASGRP1 levels in CD4+ T cells. By analyzing H3K27 acetylation profiles in human T cells, we identified a RASGRP1 enhancer that harbors autoimmunity-associated SNPs. CRISPR-Cas9 disruption of this enhancer caused lower RasGRP1 expression, and decreased binding of RUNX1 and CBFB transcription factors. Analyzing patients with autoimmunity, we detected reduced RUNX1 expression in CD4+ T cells. Lastly, we mechanistically link RUNX1 to transcriptional regulation of RASGRP1 to reveal a key circuit regulating RasGRP1 expression, which is vital to prevent inflammatory disease.
Dissociating decisional and temporal information in interval categorisation
Authors: Morita Vanessa C. , Sato João R. , Caetano Marcelo S. , Cravo André M. 
Published: June 2019

AbstractInterval timing is fundamental for humans and non-human animals to interact with their environment. Several studies that investigate temporal processing combine behavioural tasks with neurophysiological methods, such as electrophysiological recordings (EEG). However, in the majority of these studies, it is hard to dissociate whether EEG activity reflects temporal or decisional information. In the present study, we investigated how time and decision is encoded in the EEG signal while human participants performed a temporal categorisation task with two different temporal references. Using a combination of evoked potentials and multivariate pattern analysis, we show that: (1) During the interval to-be-timed, both temporal and decisional information are encoded; (2) Activity evoked by the end of the interval encodes almost exclusively decisional information. These results suggest that decisional aspects of the task better explain EEG activity commonly related to temporal processing. The interplay between the encoding of time and decision is consistent with recent proposals that approximate temporal processing with decisional models.
Behavioral and neural signatures of working memory in childhood
Authors: Rosenberg Monica D. , Martinez Steven A. , Rapuano Kristina M. , Conley May I. , Cohen Alexandra O. , Cornejo M. Daniela , Hagler Donald J. , Anderson Kevin M. , Wager Tor D. , Feczko Eric , Earl Eric , Fair Damien A. , Barch Deanna M. , Watts Richard , Casey BJ 
Published: June 2019

AbstractWorking memory function changes across development and varies across individuals. The patterns of behavior and brain function that track individual differences in working memory during development, however, are not well understood. Here we establish associations between working memory, cognitive abilities, and functional MRI activation in data from over 4,000 9–10-year-olds enrolled in the Adolescent Brain Cognitive Development study, an ongoing longitudinal study in the United States. Behavioral analyses reveal robust relationships between working memory, short-term memory, language skills, and fluid intelligence. Analyses relating out-of-scanner working memory performance to memory-related fMRI activation in an emotional n-back task demonstrate that frontoparietal activity in response to an explicit memory challenge indexes working memory ability. Furthermore, this relationship is domain-specific, such that fMRI activation related to emotion processing during the emotional n-back task, inhibitory control during a stop-signal task, and reward processing during a monetary incentive delay task does not track memory abilities. Together these results inform our understanding of the emergence of individual differences in working memory and lay the groundwork for characterizing the ways in which they change across adolescence.
Multi-task learning of a deep k-nearest neighbour network for histopathological image classification and retrieval
Authors: Peng Tingying , Boxberg Melanie , Weichert Wilko , Navab Nassir , Marr Carsten 
Published: June 2019

AbstractDeep neural networks have achieved tremendous success in image recognition, classification and object detection. However, deep learning is often criticised for its lack of transparency and general inability to rationalize its predictions. The issue of poor model interpretability becomes critical in medical applications, as a model that is not understood and trusted by physicians is unlikely to be used in daily clinical practice. In this work, we develop a novel multi-task deep learning framework for simultaneous histopathology image classification and retrieval, leveraging on the classic concept of k-nearest neighbors to improve model interpretability. For a test image, we retrieve the most similar images from our training databases. These retrieved nearest neighbours can be used to classify the test image with a confidence score, and provide a human-interpretable explanation of our classification. Our original framework can be built on top of any existing classification network (and therefore benefit from pretrained models), by (i) adding a triplet loss function with a novel triplet sampling strategy to compare distances between samples and (ii) a Cauchy hashing loss function to accelerate neighbour searching. We evaluate our method on colorectal cancer histology slides, and show that the confidence estimates are strongly correlated with model performance. The explanations provided by nearest neighbors are intuitive and useful for expert evaluation by giving insights into understanding possible model failures, and can support clinical decision making by comparing archived images and patient records with the actual case.
Household socio-economic status and likelihood of HIV infection among under five-year children in Muheza district, north-eastern Tanzania
Authors: Bwana Veneranda M. , Simulundu Edgar , Mboera Leonard E.G. , Mfinanga Sayoki G. , Michelo Charles 
Published: June 2019

AbstractBackgroundThere are evidences of the association between socio-economic factors and HIV prevalence in Sub-Saharan Africa. However, there is dearth of information on such relationship in Tanzania. Here, we present data on the relationship between household’s socio-economic factors and HIV prevalence among under five-year children in Muheza district, Tanzania.MethodsWe conducted a facility-based study from June 2015 to June 2016 in which we enrolled under five-year children born to HIV positive mothers. Information on HIV status of the child and socio-demographic characteristic of the head of the household was collected using a structured questionnaire. Data analysis was done using STATA version 13.0.ResultsA total of 576 mothers/guardians were interviewed each with respective HIV exposed under five-year child. Children who belonged to a head of household with at least a high education level (AOR= 0.4, 95% CI 0.2-0.8) and living in a relatively wealthy household (AOR = 0.5, 95% CI 0.2-0.9) was associated with reduced odds of HIV infection among children. Univariate analysis revealed that the odds of HIV infection was three-fold (COR = 2.9, 95% CI 1.2-7.0) higher among children living in rural than in urban areas. The heads of household living in rural areas (AOR=0.3 95% CI 0.1-0.9) had low education level compared to those living in urban areas.ConclusionChildren who belong to the head of households with high educational level, high household wealth were associated with reduced likelihood of HIV infection in Tanzania. Children living in rural areas had increased likelihood of acquiring HIV infection. These findings stress the need to focus on improving education status of the population and economically disadvantaged populations as a strategy for HIV prevention and control measures.
Characteristics of a co-flowing jet with varying lip thickness and constant bypass ratio
Authors: R. Naren Shankar , S. Kevin Bennett 
Published: June 2019

Purpose
Subsonic commercial aircraft operate with turbo-fan engines that operate with moderate bypass ratio (BR) co-flowing jets (CFJ). This study aims to analyse CFJ with constant BR 6.3 and varying primary nozzle lip thickness (LT) to find a critical LT in CFJ below which mixing enhances and beyond which mixing inhibits.

Design/methodology/approach
CFJ were characterized with a constant BR of 6.3 and varying lip thicknesses. A single free jet with a diameter equal to that of a primary nozzle of the co-flowing jet was also studied for comparison.

Findings
The results show that within a critical limit, the mixing enhanced with an increase in LT. This was signified by a reduction in potential core length (PCL). Beyond this limit, mixing inhibited leading to the elongation of PCL. This limit was controlled by parameters such as LT and magnitude of BR.

Practical implications
The BR value of CFJ in the present study was 6.3. This lies under the moderate BR value at which subsonic commercial turbofan operates. Hence, it becomes impervious to study its mixing behavior.

Originality/value
This is the first effort to find the critical value of LT for a constant BR for compressible co-flow jets. The CFJ with moderate BR and varying LT has not been studied in the past. The present study focuses on finding a critical LT below which mixing enhances and above which mixing inhibits.
Published errors and errata in library and information science journals
Authors: Erfanmanesh Mohammadamin , Morovati Marzieh 
Published: June 2019

Purpose
This paper aims to investigate the characterization of corrections to the papers published in Library and Information Science (LIS) journals during 2006-2015. It studies the frequency and location of the published errors, time interval between the publication of the original papers and their corrections, as well as associations between journals’ impact factors (IF) and their correction rates.

Design/methodology/approach
The population of the study comprised of 369 errata published in 50 LIS journals. The data were obtained from Clarivate Analytics’ Web of Science (WoS) and Journal Citation Reports.

Findings
The results of the study revealed a correction rate of 0.37 per cent for LIS journals, which is substantially lower than that of 124 subject categories with at-least one erratum in the WoS. Among the countries with the highest number of errata in LIS journals, the USA ranked first, followed by China and England. However, the greatest share of errata to overall LIS publications of the country was seen in Kazakhstan, Russia and Botswana. Results showed that no statistically significant relationships existed between the journals’ IF and their correction rates. The highest proportion of errors published in LIS literature was occurred in authors’ information, references, tables and figures. Moreover, the average time from publication of the original articles to their corresponding errata was found to be 8.7 months.

Social implications
Correcting the unintentional mistakes in scholarly articles is an ethical responsibility of researchers and journal editors.

Originality/value
The current research tries to investigate the characteristics of errata in the LIS field.
Luxury international business: a critical review and agenda for research
Authors: Roberts Joanne 
Published: June 2019

PurposeThrough a critical review of the impact of luxury international business, this study aims to contribute to an understanding of business activities that depend on an unequal distribution of income and wealth.Design/methodology/approachDrawing on a wide range of academic and practitioner literature, this study adopts a critical luxury studies approach to provide an assessment of the economic and social impact of luxury international business.FindingsLuxury is an increasingly important sector of the economy, which contributes to the welfare of increasing numbers of people across the world. Alongside its dependence on an unequal distribution of income and wealth and the negative aspects to which this gives rise, luxury business generates significant benefits to the economy and society through promoting economic growth, innovation, cultural enrichment, improved quality of the built environment and environmentally sustainable business practices. Nevertheless, an appropriate level of regulation and taxation on the excesses of contemporary luxury consumption could improve the welfare of all. Hence, luxury international business warrants investigation by critical scholars who recognize the complexity of the benefits and dark sides arising from luxury.Research limitations/implicationsThis study draws on an extensive review of academic and practitioner literature. However, primary research is required to investigate further the key issues identified.Social implicationsThrough an exploration of the impact of the production and consumption of luxury, this study reveals how luxury businesses serving the super-rich can contribute to the welfare of society whilst also giving rise to negative outcomes.Originality/valueBy adopting a critical luxury studies approach, this study offers an original contribution to the field of international business and introduces avenues for future critical international business research.
MNCs’ corporate environmental responsibility in emerging and developing economies
Authors: Becker-Ritterspach Florian , Simbeck Katharina , El Ebrashi Raghda 
Published: June 2019

Purpose
This paper aims to provide multinational corporations (MNCs) with a portfolio of corporate environmental responsibility (CER) responses that help curbing the exacerbated negative environmental externalities caused by their business activities in emerging and developing economies.

Design/methodology/approach
This paper transposes the market-related concept of institutional voids to the context of CER, that is, to the context of exacerbated negative environmental externalities as result of absent, weak or incoherent institutions.

Findings
This paper proposes that the transfer of products, processes and business models from developed to emerging or developing economies often gives rise to exacerbated negative externalities because of institutional voids in environmental protection. Thus, it suggests a portfolio of CER responses – circumventing, coping and compensating – that allow MNCs to mitigate the exacerbated negative environmental externalities caused by them.

Research limitations/implications
The authors present an analytical framework for identifying and navigating environment related institutional voids, which serves as a starting point for an action research approach. In tune with recent calls for critical performativity in critical management studies, the action research approach aims at tackling the real-life problem of exacerbated negative environmental externalities caused by MNCs’ activities in emerging and developing economies.

Social implications
This paper sensitizes scholars, policymakers and managers to exacerbated negative environmental externalities within the context of international business activities in emerging and developing economies. The contribution provides stakeholders with a better understanding of the causes as well as alternative responses to the problem.

Originality/value
This paper transposes the market-related concept of institutional voids and the strategic responses to dealing with them to the non-market context of CER. The authors argue that institutional voids can be seen as the absence or poor functioning of formal and informal institutions for environmental protection, resulting in exacerbated negative environmental externalities.
Application of the person-centered model to stress and well-being research
Authors: Somers Mark , Birnbaum Dee , Casal Jose 
Published: June 2019

PurposeThe purpose of this paper is to investigate profiles of employee well-being using multiple components to better understand how well-being is experienced in organizations.Design/methodology/approachA survey design with 579 health care workers in the USA was administered. Latent profile analysis (LPA) was used to identify well-being profile groups.FindingsSix well-being profile groups based on the relative levels of work stress, carry-over stress and job satisfaction were identified. Profile groups differed with respect to intention to remain in the organization and occupation, and job search behavior.Practical implicationsModels of well-being at work have generated consistently disappointing results that have not enhanced the development of programs to increase well-being at work. By identifying patterns of well-being, this study offers insights into how well-being is experienced so that more targeted programs to promote it can be implemented.Originality/valueAlthough there is increased interest in the person-centered model in organizational research, it has not been applied to psychological well-being at work. This study represents an initial attempt to study configurations of well-being based on its components. Results indicate that distinct patterns of well-being are present, and those patterns are useful in gaining a greater understanding of how well-being is experienced and in how it can be more effectively managed.
Implemented and perceived high-performance work system and its effect on branch performance
Authors: Ali Muhammad , Lei Shen , Freeman Susan , Khan Mubbsher Munawar 
Published: June 2019

PurposeThe purpose of this paper is to examine the influence of high-performance work systems (HPWS) on unit performance relative to the mediating roles of collective human capital (CHC) at the unit level and perceived HPWS at the employee level.Design/methodology/approachData were collected from 181 branch managers and 504 employees. The proposed path model was tested using the statistical package M-plus (v. 7) using a 2-1-2 multilevel approach for mediation analysis.FindingsGenerally, branch managers actively implement HPWS, and employees perceive a fairly high level of HPWS. Further, the path model indicated that CHC at the unit level and perceived HPWS at the employee level partially mediate the relationship between implemented HPWS and unit performance.Originality/valueThis study is the first to explore multilevel mediating mechanisms in the context of the largest four state-owned banks in China. A 2-1-2 multilevel analysis procedure was used to separate measurement error into relevant employee- and branch-level components to create more precise assessments of multivariate associations. Such analyses have not yet been conducted in research on HPWS prior to this study of the Chinese banking sector, but they are essential for teasing out the micro- and macro-level effects of HPWS.
High-commitment work systems and employee voice
Authors: Zhang Junwei , Akhtar Muhammad Naseer , Zhang Yajun , Rofcanin Yasin 
Published: June 2019

PurposeAlthough scholars have suggested that employees often carefully consider social contexts before enacting voice, few studies have explored whether firms foster employee voice behavior by adopting a set of systematic HR practices, namely, high-commitment work systems (HCWS). By integrating the literature on HCWS and voice, the purpose of this paper is to explore the mechanisms of how HCWS utilization influences employee voice.Design/methodology/approachThe authors adopted multilevel analyses with HLM software to examine the research hypotheses. The authors collected data from a sample of 290 employees and 58 line managers from 11 software design and development firms in China.FindingsHCWS utilization positively affected employee-experienced HCWS which enhanced psychological safety and perceived organizational support, and in turn employee voice behavior. In addition, HCWS utilization positively influenced employee-experienced HCWS, and subsequently increased voice efficacy. However, contrary to the expectations, voice efficacy was not related to employee voice.Originality/valueThe study is the first to integrate research on HCWS and voice. By building on the theory of planned behavior, the authors provide new insights into the relationship between HCWS utilization and employee voice and inspire researchers to elucidate other explanatory mechanisms in this link.
Sport hunting and tourism in the twenty-second century: humans as the ultimate trophy
Authors: Wright Daniel William Mackenzie 
Published: June 2019

Purpose
This paper aims to address the potential of hunting humans as sport tourism activity in the twenty-second century. The paper explores past and current trends related to sport hunting, animal extinction, human violence and the normalisation of violence via fictional media. This paper paints a provocative picture of society with the aim of encouraging dialogue across the wider community regarding the challenges facing society in relation to practices related to sport hunting and tourism.

Design/methodology/approach
This paper takes a scenario narrative approach in presenting potential discussion on the future of sport hunting as a tourism activity. The importance of narrative writing as a method to research is its ability in telling a story to the reader. By embracing diverse philosophical methods, this research draws on past and current trends via secondary data sources to justify the future scenario narrative.

Findings
This paper presents interesting insights into the future of sport hunting and its potential relationship to tourism. However, considering the following quote, “Yet another uncertainty is that predictions themselves can alter the future – which, of course, is part of the motivation behind futurism” (Larson, 2002, p. 5), this paper concludes with a sobering message, if previous research as well as the ideas presented here are to become a future reality, one where humans hunt each other for sport, are we content to allow this to happen? Or do we want to encourage debate to ensure we create better futures?

Originality/value
This paper offers original and novel research within the sport-tourism literature by taking a futures perspective and applying a scenario narrative approach. The paper offers original insight into attitudes towards sport hunting and its future potential, moving away from its traditions of hunting animals to hunting humans. This paper encourages debate around a taboo-subject, by drawing on a popular past-time, sport. Death is also universal, and by aligning the topic with sport and as a hunting activity, this paper is offering original approaches to addressing difficult questions that need to be asked.