bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of Fra‐1, c‐Jun and c‐Fos in odontogenic keratocysts: potential correlation with proliferative and anti‐apoptotic activity
Authors: Zhang Lin‐Zhou , Man Qi‐Wen , Liu Jin‐Yuan , Zhong Wen‐Qun , Zheng Yue‐Yu , Zhao Yi‐Fang , Liu Bing 
Published: July 2018

AimsThe purpose of this study was to explore the potential involvement of Fra‐1, c‐Jun and c‐Fos, three vital members of the AP‐1 complex, in the pathogenesis of odontogenic keratocysts (OKCs).Methods and resultsTissue samples, containing 10 normal oral mucosa (OM), 10 dentigerous cysts (DC) and 32 OKC specimens, were applied to investigate the expression levels of Fra‐1, c‐Jun and c‐Fos by immunohistochemistry and real‐time–quantitative polymerase chain reaction (RT–qPCR). The association between Fra‐1, c‐Jun and c‐Fos expression levels and markers of proliferation [Ki‐67, proliferating cell nuclear antigen (PCNA)], anti‐apoptosis (Bcl‐2) was then investigated in the OKC serial tissue sections. The results showed that Fra‐1, c‐Jun and c‐Fos expression levels were increased significantly in OKCs compared to these in OM and DC tissue samples. Meanwhile, the expression levels of Fra‐1, c‐Jun and c‐Fos were associated positively with the expression levels of Ki‐67, PCNA and Bcl‐2, as confirmed further by double‐labelling immunofluorescence analysis and hierarchical analysis.ConclusionsThis study revealed for the first time that Fra‐1, c‐Jun and c‐Fos were overexpressed in OKCs and had a close correlation with proliferation and anti‐apoptosis potential of OKCs.
Influence of Mg doping on the structural, optical, and electrical properties of Zn0.95Li0.05O Nanoparticles
Authors: Demirozu Senol Sevim 
Published: July 2018

AbstractThis study investigates the effect of Li and Mg codoping on the structural, optical, and electrical properties of the ZnO. Zn0.95−xLi0.05MgxO (x = 0.00, 0.01, 0.02, 0.03) nanoparticles are synthesized by hydrothermal method. X‐ray diffraction (XRD) results confirmed that all samples are polycrystalline with a hexagonal‐wurtzite structure. The surface morphology of the samples were examined by Scanning Electron Microscopy (SEM). The SEM analysis showed that all samples exhibit cheese‐like plates and the plate sizes increase with Mg addition. Optical properties were examined by UV‐VIS diffuse reflectance spectroscopy. The optical measurements indicate that the reflectance edge of the samples have red shift up to 2% Mg doping level, but blue‐shift for 3% Mg doping. The optical band gap of Zn0.95−xLi0.05MgxO nanostructures are calculated as 3.227, 3.214, 3.209, and 3.221 eV with x = 0.00, 0.01, 0.02, 0.03 respectively. Electrical properties including the carrier concentration, Hall mobility, and resistivity were studied using Van‐der Pauw method. The temperature resistivity curves of the samples shown typical semiconductor behavior. The carrier concentration decreases with increasing doping level up to 2% Mg, and it slightly increases for 3% Mg. The variation of the Hall mobility for the samples is inversely proportional to the carrier concentration.
Income distribution and economic crises
Authors: Neyapti Bilin 
Published: July 2018

AbstractThis study presents an original empirical analysis of the relationship between income inequality and recession severity, measured by the length and depth of recessions. For this purpose, an extensive panel data set was constructed, whereby each observation corresponded to a recession episode. The empirical analysis yielded two novel findings. First, pre‐recession inequality and recession severity are weakly related to each other, as a negative and statistically significant relationship is only observed for middle and high levels of income and governance. Second, the relationship between recession length and post‐recession income inequality is positive and highly significant in low‐ and middle‐income countries. This relationship is insignificant in high‐income countries due, possibly, to their high capacity to accommodate for the impacted low‐income groups.
Iron‐depleted Bi‐YIG having enhanced gyromagnetic properties suitable for LTCC processing
Authors: Jia Ning , Zhang Huwiwu , Harris Vincent G. 
Published: July 2018

AbstractThe traditional method of ferrite synthesis is based upon solid‐state reaction. The advantages of this approach include simplicity, cost effectiveness, and suitability for commercial process scaling. However, there exist shortcomings in that impurities and defects adversely affect magnetic properties. Here, iron‐depleted compositions of bismuth‐substituted yttrium iron garnet (ie Bi:YIG) were studied with emphasis placed on the impact of synthesis processing parameters upon the structure and gyromagnetic properties. It was shown that ferrimagnetic resonance linewidth experienced a minimum of 180.3 Oe (X‐band) when the sample stoichiometry was 4% depleted in iron (x = 0.2), a reduction of 29.3% from the parent compound. Concomitantly, iron depletion caused a systematic change in lattice parameter that resulted in a dilation of Goodenough‐Kanamori‐Anderson bond angles increasing exchange energy and magnetization. The substitution of Bi for Y on the dodecahedron sites altered the reaction path and decreased the activation energy effectively reducing sintering temperature. To establish a functional processing protocol, an ion diffusion model is presented to explain the demonstrated processing, structure, and performance paradigm.
Young children with significant developmental delay differentiate home observed attachment behaviour towards their parents
Authors: Vandesande Sien , Bosmans Guy , Schuengel Carlo , Maes Bea 
Published: July 2018

AbstractBackgroundThe hallmark of attachment is that contact, proximity and relief from stress are sought from specific individuals, laying important groundwork for healthy socioemotional functioning. This study investigated the extent to which differentiated attachment behaviour can be observed in young children with significant developmental delay (DD).MethodVideo‐taped observations of the parent–child and stranger–child interaction were conducted at home and complemented with questionnaires in 20 families with a child with significant DD (age 2–7 years with an average DD of 49 months).ResultsChildren displayed more intense and persistent contact‐seeking, contact‐maintaining and resistant behaviour in the episodes with their parent compared to the episodes with the stranger. Parent‐reported secure attachment behaviour was slightly more characteristic towards mother compared to father.ConclusionsEven children with significant DD develop differentiated attachment behaviour. Detailed observations may support parents in identifying the interactions that make the attachment relationship with their child special.
Physical activity levels of children and adolescents with moderate‐to‐severe intellectual disability
Authors: Wouters Marieke , Evenhuis Heleen M. , Hilgenkamp Thessa I. M. 
Published: July 2018

AbstractBackgroundRegular participation of children and adolescents with intellectual disabilites in physical activity is important to maintain good health and to acquire motor skills. The aim of this study was to investigate the habitual physical activity in these children.MethodsSixty‐eight children and adolescents (2–18 years) with a moderate‐to‐severe intellectual disability were included in the analyses. They wore an accelerometer on eight consecutive days. Data was analysed by use of descriptive statistics and multiple linear regression analyses.ResultsThe participants took on average 6,677 ± 2,600 steps per day, with intensity of 1,040 ± 431 counts per minute. In total, 47% of the participants were meeting physical activity recommendations. Low motor development was associated with low physical activity.ConclusionsAs more than half of the participants were not meeting the recommendations, family and caregivers of these children should focus on supporting and motivating them to explore and expand their physical activities.
Pan‐Mediterranean Holocene vegetation and land‐cover dynamics from synthesized pollen data
Authors: Woodbridge Jessie , Roberts Neil , Fyfe Ralph 
Published: July 2018

AbstractAimThe Mediterranean is characterized by diverse and spatially heterogeneous mosaic landscapes. Within this study, a cluster analysis‐based method is developed for the classification of Mediterranean vegetation types based on modern and fossil pollen datasets. The application of this approach to multiple pollen records spanning the Mediterranean region has allowed temporal variations in vegetation dynamics to be explored throughout the Holocene. We ask how far back stable baseline vegetation communities can be identified in the pollen record, and whether those types considered to be characteristic of the Mediterranean landscapes have been present in the past as well as at the present.LocationThe research location includes the land areas surrounding the Mediterranean Sea. The pollen sites are principally located in mainland Spain, southern France, Greece and Turkey, Italy, North Africa, the Levant, and some Mediterranean islands.MethodsA total of 5,641 samples from 158 fossil pollen records (cores) and 1,799 modern pollen surface samples were harmonized taxonomically and pollen count data summed into 200‐year time windows on a common time‐scale from 11,000 bp to the present‐day. Cluster analysis and community classification were used to identify major vegetation types along with other approaches to explore patterns in ecological datasets, such as Simpson's diversity index and nonmetric multidimensional scaling.ResultsThe pollen datasets were classified into 11 closed forest/woodland and five open or scrubland vegetation types. Closed vegetation clusters declined from the mid‐Holocene with a marked increase in open or human‐modified vegetation types since 3,500 bp and with an increasing rate of vegetation change and habitat diversity through time.Main conclusionsThe Mediterranean has been a dynamic landscape throughout the Holocene with frequent changes in land cover identified in the pollen datasets. The pollen‐inferred clusters reveal a wider range of Mediterranean vegetation types than identified in previous studies; for example, including both beech and alder woods. Evergreen Oleaceae‐dominated shrubland is much better represented in modern than in fossil samples while mesic forest was abundant in the past but is uncommon today.
Reducing pediatric psychiatric hospital readmissions and improving quality care through an innovative Readmission Risk Predictor Tool
Authors: Ramsbottom Helen , Farmer Lisa Collier 
Published: July 2018

AbstractProblemLess than 30‐day readmission has become a national problem. This pediatric medical center discovered that the primary diagnosis of Mood Disorder, not otherwise specified, was the third most common readmission diagnosis hospital‐wide. Administration actively sought a resolution to less‐than‐30‐day readmissions because All‐Patient‐Refined‐Diagnostic‐Related Groups would soon include pediatric hospitals with reimbursement impact.MethodsThe Iowa Model for evidence‐based practice framed the work of case management to identify readmission risk, reduce readmissions, and improve patient quality. In July 2014, the Readmit Predictor Tool (RPT) and Protocol were developed from literature review of contributing factors of pediatric psychiatric readmissions and assessed levels of readmission risk. The nurse case manager provided follow‐up telephone calls to caregivers with children identified as moderate‐to‐high risk for readmissions.FindingsEffects of RPT use resulted in decreased readmissions by 29.5% in the first year, followed by 7.8% and 5.1% reductions in the second and third years, respectively, despite substantial increases in patient acuity during the period.ConclusionUsing the RPT and initiating the psychiatry nurse case manager position, less‐than‐30‐day readmissions decreased over a 3‐year period.
Proposed a simple score for recommendation of scheduled ultrasonography surveillance for hepatocellular carcinoma after Direct Acting Antivirals: multicenter analysis
Authors: Hiraoka Atsushi , Kumada Takashi , Ogawa Chikara , Kariyama Kazuya , Morita Masahiro , Nouso Kazuhiro , Toyoda Hidenori , Tada Toshifumi , Ochi Marie , Murakami Taisei , Izumoto Hirofumi , Ueki Hidetaro , Kitahata Shogo , Aibiki Toshihiko , Okudaira Tomonari , Yamago Hiroka , Iwasaki Ryuichiro , Tomida Hideomi , Miyamoto Yuji , Mori Kenichiro , Miyata Hideki , Tsubouchi Eiji , Kishida Masato , Ninomiya Tomoyuki , Michitaka Kojiro 
Published: July 2018

AbstractBackground and AimTo develop a scoring method using with common clinical data for predicting hepatocellular carcinoma (HCC) development after sustained virological response at 24 weeks (SVR24) after treatment with direct acting antivirals (DAAs), we retrospectively evaluated clinical features of patients who obtained SVR24.MethodsFrom October 2014 to December 2017, 1069 hepatitis C virus patients without a past history of HCC, who obtained SVR24 by DAAs at two different areas, were enrolled (the training [n = 484, ChuShikoku‐group] and validation [n = 585, Chubu‐group] sets). All were examined by ultrasonography as surveillance for HCC at the time of starting DAAs and twice a year after SVR24. We identified three parameters at SVR24, male gender, FIB‐4 index > 3.25, and α‐fetoprotein level > 5.0 ng/mL, as risk factors for HCC development and gave them point values, with the sum used as After DAAs Recommendation for Surveillance (ADRES) score.ResultsIn the ChuShikoku‐group, the respective 1‐/2‐year rates for HCC incidence rates ADRES score 0 were 0.0%/0.0%, for a score 1 were 1.1%/2.1%, score 2 were 8.8%/15.9%, and score 3 were 17.1%/28.1%. On the other hand, those respective scores for the Chubu‐group were 0.0%/0.0%, 0.0%/0.7%, 7.9%/10.6%, and 19.5%/not available. The c‐index of the predictive value for HCC development in the training set after SVR24 was 0.835 while 0.899 in the validation set. Finally, those of the entire cohort were 0.0%/0.0%, 0.5%/1.6%, 8.4%/13.4%, and 18.0%/32.8%.ConclusionThe present ADRES score was simple and easy to use and may be useful for predicting risk of HCC development in short term after reaching SVR24 by DAAs.
Texture‐modified foods and thickened fluids used in dysphagia: Israeli standardised terminology and definitions
Authors: Icht M. , Bergerzon‐Bitton O. , Kachal J. , Goldsmith R. , Herzberg O. , Endevelt R. 
Published: July 2018

AbstractBackgroundTexture‐modified foods and thickened fluids are used as a strategy that aims to compensate for dysphagia and improve the safety and efficiency of swallowing. Currently, in Israel, there are no standardised terminologies and definitions for texture‐modified diets. The inconsistent terminology adversely affects patient safety and the efficiency of communication between staff members both within and between health institutions. This present study describes a project of the Israeli Ministry of Health in which the labels and definitions of prevalent foods and fluids used in health institutions are mapped to develop a consensus on national standards.MethodsA multidisciplinary committee of speech‐language pathologists (SLPs) and registered dietitians (RDs) was appointed. A questionnaire was developed to identify the labels of texture‐modified foods and fluids used in the Israeli healthcare system. The questionnaire included questions on knowledge, attitudes and barriers related to the need for a consistent national terminology for texture‐modified diets. Questionnaires were sent to 120 institutions. The project was conducted between September 2016 and December 2017.ResultsTwenty‐six SLPs and 42 RDs responded. The answers revealed that there were 50 labels in use for texture‐modified foods. When asked to describe the texture of a particular food item, up to 17 different labels were used. There was broad support for a standardised terminology.ConclusionsThe results of the present study confirm the lack of national standards in clinical practice and the need for a consistent terminology. A consensus was achieved between the committee members and the committee adopted the International Dysphagia Diet Standardization Initiative (IDDSI) recommendations and adapted the terminology to Hebrew.
Estimating the Material Stock of Roads: The Vietnamese Case Study
Authors: Nguyen Thi Cuc , Fishman Tomer , Miatto Alessio , Tanikawa Hiroki 
Published: July 2018

SummaryThis study is a pioneering effort to quantify the materials stocked in the road network of a developing country, Vietnam, and analyze its relationships to the country's recent economic development. National road networks function as capital and infrastructure investments that are necessary catalysts for countries’ development, while requiring the extraction of vast amounts of construction materials for expansion and maintenance causing environmental impacts. However, there has so far been little research on the subject, especially in developing countries. We compile material stock and flow accounts for Vietnam's roads from 2003 to 2013 on the national and provincial levels, finding that approximately 40% of the domestic consumption of construction materials is for expanding and maintaining the road network, and the materials stocked in the road network doubled from 1,321 million metric tons in 2003 to 2,660 million metric tons in 2012. Material stock growth rates closely resembled those of gross domestic product (GDP) in this period, suggesting a codependency of physical infrastructure development and economic development. On the provincial level, our results show local disparities in the stock and its capacity to support the transportation of passengers and freight, especially considering the surging growth of vehicles in urban centers. By showcasing the challenges of conducting a material flow and stock analysis in a developing country, this study not only sheds light on Vietnam's transportation material stock and its policy implications, but also serves as a case study for further work in similar countries.
Access to assistive technology for people with intellectual disabilities: a systematic review to identify barriers and facilitators
Authors: Boot F. H. , Owuor J. , Dinsmore J. , MacLachlan M. 
Published: July 2018

AbstractBackgroundThe World Health Organisation has launched a programme to promote Global Cooperation on Assistive Technology. Its aim is to increase access to high‐quality affordable assistive products (AP) for everybody in need. People with intellectual disabilities (ID) are a specific group that could benefit from AP, but use less AP compared to their non‐intellectual disabled peers.MethodA systematic literature search was carried out to identify barriers and potential facilitators for access to AP for people with ID globally. The search strategy terms were ‘Intellectual Disability’ and ‘Assistive Technology’ with the following electronic literature databases PubMed, Embase, ASSIA, Web of Science, Medline, CINAHL complete, PsycInfo, Scopus and ERIC. The quality and relevance of the studies were assessed. Factors associated with access were identified thematically, categorised into barriers and facilitators and mapped into themes.ResultsIn all, 22 key studies were retrieved, describing 77 barriers and 56 facilitators. The most frequently reported barriers were related to lack of funding and cost of AP, lack of awareness about AP and inadequate assessment. An increase of knowledge and awareness about AP and the need of AP for people with ID were most often extracted as factors that could potentially facilitate access.ConclusionsThis review proposes actions linked to the barriers and facilitators that have a particular importance for people with ID to access AP. Yet, only limited research is available describing factors that influence access to AP for people with ID in low and middle income countries and rural areas.
Effects of sperm direction in Piezo‐ICSI on oocyte survival, fertilization, embryo development and implantation ability in humans: A preliminary study
Authors: Hiraoka Kenichiro , Kitamura Seiji , Otsuka Yoshihito , Kawai Kiyotaka , Harada Tatsuya , Ishikawa Tomonori 
Published: July 2018

AbstractAimsThe objective of this study was to investigate the effect of the head‐first or tail‐first injection of sperm into the cytoplasm by Piezo‐ICSI (PICSI) on oocyte survival, fertilization, embryo development and implantation ability in humans.MethodsWe retrospectively investigated 632 mature oocytes retrieved from 152 infertile patients who attended our PICSI‐ET program at the Niji Clinic between October 2010 and January 2014. Of these, 342 mature oocytes retrieved from 75 patients were injected with sperm head first, and 290 mature oocytes retrieved from 77 patients were injected with sperm tail first into the cytoplasm. The rates of oocyte survival, fertilization, good‐quality day‐3 embryos, pregnancy, implantation and live birth were evaluated in both groups.ResultsThere were no differences among the two groups with respect to survival, fertilization, good‐quality day‐3 embryos, pregnancy, implantation and live birth rates.ConclusionSperm direction (i.e., head first or tail first) does not influence the outcome of PICSI in human oocytes, including oocyte survival, fertilization, embryo development and implantation ability. These findings contribute to an understanding of factors that influence the success of human intracytoplasmic sperm injection (ICSI) techniques.
Body Dissatisfaction, Perceptions of Competence, and Lesson Content in Physical Education
Authors: Kerner Charlotte , Haerens Leen , Kirk David 
Published: July 2018

ABSTRACTBACKGROUNDSignificant proportions of young people experience body dissatisfaction, which has implications for psychological and physical well‐being. Lesson content and perceived competence may be important variables for the experience of body dissatisfaction, yet these have been underexplored in physical education. The aim of this cross‐sectional study is to identify the relationships between body dissatisfaction and perceptions of competence, and to explore whether body dissatisfaction depends on lesson content.METHODSA paper‐and‐pencil questionnaire was completed by 446 (210 boys, 236 girls) 13‐ to 14‐year‐old pupils from 37 physical education classes. The questionnaire assessed body dissatisfaction and perceived competence in physical education. Lesson content was also recorded. Twenty‐nine of the classes were engaged in team activities, eg, ball games. Eight classes were engaged in individual activities, eg, fitness.RESULTSMultilevel analysis identified a significant negative association between body dissatisfaction and perceptions of competence in physical education. Lesson content did not significantly predict variations in body dissatisfaction scores.CONCLUSIONSTeachers should focus on enhancing pupils' perceptions of competence in physical education to support the development of body satisfaction.