bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dengue serosurvey after a 2-month long outbreak in Nîmes, France, 2015: was there more than met the eye?
Authors: Succo Tiphanie , Noël Harold , Nikolay Birgit , Maquart Marianne , Cochet Amandine , Leparc-Goffart Isabelle , Catelinois Olivier , Salje Henrik , Pelat Camille , de Crouy-Chanel Perrine , de Valk Henriette , Cauchemez Simon , Rousseau Cyril 
Published: June 2018

Background
Clusters of dengue cases have recently become more frequent in areas of southern France colonised by the vector mosquito Aedes albopictus. In July 2015, a 2-month outbreak of dengue virus serotype 1 (DENV-1) was reported in Nîmes. Aim: We conducted a serosurvey in the affected area at the end of the vector activity period to determine the true extent of dengue transmission. Methods: We collected capillary blood from consenting household members, and information on their medical and travel histories, and exposure to mosquito bites. Recent infections were identified using IgM and IgG anti-DENV ELISA, followed, when positive, by plaque reduction neutralisation tests on serum against DENV 1–4 and West Nile virus. The prevalence estimator was calibrated on reference demographic data. We quantified the spatial clustering of dengue cases within the affected community and inferred the transmission tree. Results: The study participation rate was 39% (564/1,431). Three of 564 participants tested positive for DENV-1 infection (after marginal calibration, 0.41%; 95% confidence interval: 0.00–0.84). The spatial analysis showed that cases were clustered at the household level. Most participants perceived the presence of mosquitos as abundant (83%) and reported frequent mosquito bites (57%). We incidentally identified six past West Nile virus infections (0.9%; 95% CI: 0.2–1.6). Conclusion: This serosurvey confirms the potential for arboviral diseases to cause outbreaks − albeit limited for now − in France and Europe.
Effects of Professional Development and Videoconferencing on the Increase of Opportunities to Respond and the On-Task Behavior of Students with Emotional Behavior Disorders
Authors: L Carmouche Millicent , L Thompson Jelisa , S Carter LaTiegra 
Published: June 2018

Aim/Purpose: This study explored an alternative means to offering supervisory coaching to teachers, professional development, and virtual teacher coaching through the use of videoconferencing.

Background: Teacher coaching has been identified as an effective way to improve teacher implementation of research proven effective classroom strategies. The use of technology to implement coaching widens the audience of coaches that one coach can reach.

Methodology	: A single-case multiple baseline design was used to investigate the effect the intervention had on the frequency with which teachers offer Opportunities to Respond (OTR) and on the on-task behavior of middle school students with emotional/ behavior disorders (E/BD).

Contribution: This paper expands the body of knowledge on teacher coaching to include the use of technology.

Findings: Results indicated there was a functional relationship between virtual teacher coaching with videoconferencing and teacher rates of OTR. However, no functional relationship was observed between teachers given OTR and student on-task behavior.

Recommendations for Practitioners	: The use of technology to implement coaching widens the audience of coaches that one coach can reach.

Recommendation for Researchers:	Future researchers should consider collecting data on academic information such as the number of correct responses in addition to on-task behavior.

Impact on Society	: Teacher practitioners will be able to benefit from increased access to coaches, improving effective implementation of evidence-based practices.

Future Research: Among other things, researchers could consider studying students with disabilities other than emotional/behavioral disorders and even students without disabilities may give important information on how opportunities to respond works with other populations.
Application of Liquid Chromatography with Fluorimetric Detection for the Determination of Urinary Pentosidine in Type 2 Diabetes Mellitus Patients: Effect of Telmisartan Administration on Podocyturia and Relationship with Metabolic Control
Authors: Kornhauser Carlos , Barbosa-Sabanero Gloria , Gutierrez-Romero Noemí , Sabanero Myrna , Perez-Luque Elva L. , Gómez-Ojeda Armando 
Published: June 2018

The beneficial effects of a short period of Telmisartan administration were successfully assessed trough pentosidine urinary levels (uPen) and urinary podocyte excretion (UPE), in type 2 diabetes mellitus (DM2) patients. Patients with podocyturia received Telmisartan treatment (80 mg/day) for two months. uPen were quantified pre and post treatment using HPLC with fluorimetric detection and in-lab synthesized standard. Immunofluorescence method for podocalyxin was used to evaluate urinary excretion of podocytes. uPen and UPE significantly decrease after treatment (p&lt;0.01255 and p&lt;0.005 respectively), as well as serum total cholesterol and LDL levels (p&lt;0.001). These results suggest that podocyte protection by Telmisartan even in the face of deficient metabolic control could be an important matter in the prevention and progression of diabetic nephropathy. This study also strengthens evidence of the promising role of pentosidine as prognostic and diagnostic markers in diabetic nephropathy
Application of Molecular Mass Spectrometry for The Structural Characterization of a DNA-Protein Cross-Links
Authors: Gong Jiawei , Solivio Morwena Jane , Merino Edward J , Landero Figueroa Julio Alberto 
Published: June 2018

<p>To date, many different analytical methods have been used to investigate the cross-linking reaction mechanism and to obtain the chemical structure of DNA-Protein Cross-links (DPCs). Direct MS analysis of DPCs is challenging because of the ionization properties of DNA and the protein. However, peptide sequencing and mass spectrometry (MS) as analytical techniques are playing increasingly important roles for the structure determination of DPCs model. In our previous study, a novel approach was presented for purification, detection and quantification of DPCs by newly developed inductively coupled plasma mass spectrometry (ICPMS/MS), which allows sub-ppb detection of S and P, key heteroelements in DNA and proteins.</p><p>In this study, we enhanced our previously developed method and it was complemented by the use of molecular MS to allow complete characterization of a DNA-protein cross-link. First, a small molecule model is utilized to identify the adduct structure that will likely occur in an intact DNA-protein cross-link. We investigate the thermal stability of DNA-protein cross-links, both in an intact DPC and a small molecule adduct to determine feasibility of digestion/thermal degradationof DNA without the cross-link information being lost. Thermal degradation was conducted to reduce the cross-linked DNA into a single nucleoside. The remaining protein-nucleoside adduct then was proteolytically digested, generating a peptide-nucleoside adduct. The absence of the phosphate moiety allows for facile structural characterization <em>via</em> electrospray ionization mass spectrometry (ESI-MS). Additional calculations were done for peptide matching allowing us to determine the cross-link location in the protein, made possible <em>via</em> MS/MS analysis. Additionally, we show that steric effects play an important role in DPC formation.</p>
La disputa de la ciudad: el rol de los actores sociales en la gobernanza del suelo urbano en la ciudad de Córdoba (Argentina)
Authors: Gargantini Daniela Mariana , Peresini Natalí 
Published: June 2018

<p>La ciudad se instituye como <em>locus </em>de los conflictos urbanos evidenciando las disputas de poder sobre su territorio. El acceso al suelo constituye uno de los procesos de mayor conflictividad en la consecución de un hábitat digno y de inclusión en la ciudad, por lo que considerar las representaciones y redes de interacción de los agentes involucrados favorece y potencia la comprensión de la producción física y simbólica de la ciudad. En el presente artículo se exponen, desde un enfoque cualitativo, los avances de la investigación en curso, referida al estudio del gobierno del suelo urbano en la ciudad de Córdoba (Argentina), a partir de la indagación y confrontación de las representaciones de actores sociales comunitarios influyentes, sus lógicas de comprensión y acción, así como las relaciones de articulación en torno a este conflicto urbano.</p>
Infective Endocarditis in a Neonate
Authors: Dhungana Sangita Puree , Shrestha Sabina , Shrestha Sujit Kumar 
Published: June 2018

Bacterial endocarditis in neonates is a rare. Generally neonates who develop endocarditis have required the invasive intensive care monitoring necessary for the support and treatment of a high-risk nursery population. Neonatal Infective endocarditis is usually reported as a fatal disease. With early diagnosis and treatment we can change prognosis to better side.
Meningkatkan Kemampuan Motorik Halus melalui Teknik Mozaik pada Anak Kelompok B di TK Perdana Bangkinang Kota
Authors: Fauziddin Moh 
Published: June 2018

Perkembangan kemampuan motorik halus anak usia dini kurang mendapatkan perhatian dari orang tua dan guru pada Lembaga PAUD. Hal ini banyak disebabkan kurangnya penguasaan orang tua dan guru terhadap cara yang tepat untuk mengembangkannya. Penelitian ini bertujuan untuk mengembangkan kemampuan motorik halus melalui teknik mozaik pada anak kelompok B TK Perdana bangkinang Kota, Kampar, Riau. Penelitian ini merupakan penelitian tindakan kelas (classroom action research) yang dilakukan secara kolaboratif dan partisipatif. Subjek dalam penelitian adalah 22 anak, yang terdiri dari 16 anak perempuan dan 6 anak laki-laki. Metode pengumpulan data yang digunakan adalah observasi dan dokumentasi. Instrumen penelitian menggunakan lembar observasi. Teknik analisis data menggunakan deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa teknik mozaik dapat meningkatkan kemampuan motorik halus anak kelompok B TK Perdana Bangkinang Kota. Hal ini dibuktikan pencapaian kemampuan motorik halus, anak yang berkembang sangat baik Langkah-langlah yang ditempuh dalam penelitian ini meliputi; menggunting, menempel, memegang pensil dan dan menyesuaikan warna.
Pengaruh Metode Story Telling melalui Pemanfaatan Program Power Point untuk Meningkatkan Kemampuan Mengenal Konsep Bilangan 1-10 Pada Anak Usia Dini Manyaran Semarang
Authors: Savitri Laila Nur 
Published: June 2018

Penelitian ini bertujuan untuk mengetahui (1) efektifitas metode bercerita dengan program power point untuk anak usia dini, (2) mengetahuiÂ perbedaanÂ kelompok eksperimen dan kelompok kontrol. Pendekatan pada penelitian ini adalah kuantitatif Jenis penelitian adalah desain eksperimen dengan tehnik uji t (komparasi antara kelas eksperimen dengan kelas kontrol). Objek penelitian adalah 46 siswa kelompok A di TK PGRI 59 Manyaran. Uji coba instrumen dilakukan dengan uji reliabilitas antar rater dan analisis kuantitatif dilakukan dengan analisis uji t Independent Sample T Test. Hasil penelitian menunjukan bahwa: (1) PembelajaranÂ Metode Bercerita dengan Penggunaan Program Power Point sangat efektif dengan hasil observasi kelas Eksperimen mendapatkan hasil rata-rata lebih tinggi (kelas Eksperimen 0,974, kelas Kontrol 0,767). Ini menunjukkan bahwa metode penggunaan program power point lebih diminati anak TK dibanding pembelajaran sehari-hari. (2) perbedaan antara kelompok eksperimen dan kelompok kontrol sudah terbukti, hasil dari (mean) rata-rata kelompok eksperimen 49, 9167 dan kelompok kontrol 32,9583. Hal ini dibuktikan dari hasil output SPSS sebesar 8,998 (0,05). Hasil dari P value 0,03, jadi Pvalue < 0,05. Pada derajat kebebasan 46 siswa (0,05) pada tabel kritis T (2,013). Dari hasil hitung 8,998 > 2,013. Ini menunjukan bahwa metode pembelajaran dengan penggunaan program power point di minati anak usia dini
Peningkatan Kemampuan Berbahasa Inggris Anak dengan Menggunakan Metode Total Physical Response Pada Kelompok B di TKIT Baitul Iman Semarang
Authors: Huda Nurul , Dahlia Sri Haryanti 
Published: June 2018

Penelitian ini bertujuan meningkatkan kemampuan berbahasa Inggris anak pada kelompok B di TKIT Baitul Iman Semarang sekaligus sebagai syarat untuk menempuh S1 PAUD IKIP Veteran Semarang. Metode Total Physical Response (TPR) adalah teknik mengajar bahasa Inggris kepada anak dengan menggunakan respon fisik. Jenis penelitian ini menggunakan pendekatan penelitian tindakan kelas dengan obyek penelitian 20 anak kelompok B. Sumber data berasal dari hasil lembar observasi anak selama 2 siklus dan analisis data yang digunakanÂ adalah analisis deskripsi kualitatif. Penelitian dilakukanÂ sebanyak 2 siklus, dimana siklus I prosentase tercapainya indikator keberhasilan masih 5% saja. Setelah ditemukan kekurangan dan kelebihan pada siklus I, maka perbaikan dilakukan pada siklus II. Hasil observasi pada siklus II prosentase tercapainya indikator keberhasilan meningkat tajam menjadi 75%. Dengan demikian siklus dianggap selesai
PENGGUNAAN HP ANTARA MASYARAKAT DESA PESISIR DAN MASYARAKAT DESA PEGUNUNGAN
Authors: Eko Bambang Riawan 
Published: June 2018

Handphone sebagai perangkat komunikasi banyak dimanfaatkan oleh setiap orang termasuk diantara masyarakat pesisir dan masyarakat pegunungan. Sebagai produk kebudaayaan, maka penggunaan HP sangat dipengaruhi oleh masyarakat dan sebalinya masyarakat akan memilih perangkat HP sesuai dengan kegunaannya sehingga menjadi puas. Penelitian ini menggunakan pendekatan diskriptip kuantitatif. Lokasi penelitian di Desa Jangkar Kecamatan Jangkar mewakili desa pesisir dan Desa Telogo Sari, kecamatan Sumber Malang mewakili desa pegunungan. Penggalian data melalui wawancara mendalam melalui kuesioner berstruktur kepada responden yang dipilih secara acak. Kesimpulan yang diperoleh adalah: (1) Jumlah orang yang menggunakan perangkat HP 2G saat ini masih banyak digunakan baik oleh masyarakat desa pesisir maupun desa pegunungan, sedang yang menggunakan android (4G) jumlahnya masih sedikit; (2).Telkomsel ternyata mendominasi provider baik di desa pesisir maupun di desa pegunungan. Meskipun begitu desa pesisir lebih variatif jumlah providernya lebih banyak dibanding dengan desa pegunungan; (3). Umur adalah salah satu faktor yang mempengaruhi seseorang dalam menggunakan perangkat HP
Papillary Carcinoma Arising From Infrahyoid Ectopic Thyroid Tissue with Hemi-agenesis of Thyroid Gland and Follicular Adenoma with Hürthle Cell Changes in Existing Thyroid Lobe: A Rare Case Report
Authors: Chowdhury Md Sunny Anam , Awal Md Abdul 
Published: June 2018

<p>Ectopic thyroid tissue is a rare developmental abnormality. An ectopic thyroid tissue can be subject to various pathological processes as normal thyroid tissue including tumorigenesis. This reported case is an extremely rare case of papillary thyroid carcinoma arising from infrahyoid ectopic thyroid tissue with hemiagenesis (left lobe) of thyroid gland and presence of follicular adenoma with Hürthle cell changes in the normal positioned enlarged right thyroid lobe.</p><p> Bangladesh J. Nuclear Med. 20(1): 59-62, January 2017</p>
Incidental findings (IFs) discovered during imaging: the impact on primary care
Authors: Najim Rula , Booth TC , Petkova H 
Published: June 2018

BackgroundIncidental findings (IFs) are discovered by chance and are unrelated to the patients’ clinical features. They can be life-saving but also harmful leading to unwarranted investigations and treatments. They can create anxiety for patients, and for clinicians who may have increased work-loads. Furthermore, additional appointments and investigations have economic costs.AimWe aimed to assess the impacts of IFs within primary care.MethodWritten consent was obtained for this qualitative, retrospective study which consisted of 20 semi-structured UK GP interviews using Grounded Theory. Phenomena were categorised using constant comparative analysis to achieve thematic saturation. Data on the number and duration of contacts and additional investigations needed were also recorded.ResultsIFs generated anxiety for GPs, particularly when communicating them to patients. IFs increased workload, resulting in more consultations, referrals and investigations. Neuroimaging was noted to be particularly problematic. GPs relied heavily on the written report of radiologists, who acted as patient advocates and gate-keepers of economic costs. GPs stated that direct communication with radiologists avoids unnecessary investigations and led to more satisfactory management plans. GPs wanted algorithms to manage common IFs. Access to imaging within primary care has increased and GPs acknowledged a need for greater understanding of imaging indications and their limitations.ConclusionIt is timely to analyse the impacts of IFs on primary care and to act to improve GP-radiologist communication; to improve education within primary care; and to encourage the creation of consensual and ethical guidelines on the management of common IFs.
A cluster-randomised evaluation of an adaptable implementation strategy targeting ‘high impact’ indicators in primary care
Authors: Willis Thomas A , Hartley Suzanne , Glidewell Liz , Farrin Amanda , Collinson Michelle , Holland Michael , Carder Paul , Hunter Cheryl , Meads David , Hulme Claire , Foy Robbie 
Published: June 2018

BackgroundRecognised gaps between evidence and practice in primary care present particular implementation challenges when addressing multiple priorities.AimTo evaluate the effectiveness of a multifaceted, adaptable implementation package targeting four different ‘high impact’ indicators.MethodWe undertook two parallel, pragmatic cluster randomised trials using balanced incomplete block designs with parallel process evaluation. General practices in West Yorkshire, UK, were recruited using an ‘opt out’ process. The adaptable implementation package included audit and feedback, educational outreach visits and computerised support with embedded behaviour change techniques tailored to each indicator. Practices were randomised to packages targeting either type 2 diabetes control or risky prescribing of non-steroidal anti-inflammatory drugs, or packages targeting either anticoagulation in atrial fibrillation or blood pressure control in patients at high risk of cardiovascular events. Respective primary endpoints comprised: achievement of all recommended levels of haemoglobin A1c, blood pressure and cholesterol; risky prescribing levels; anticoagulation prescribing; and achievement of recommended blood pressure levels. Outcomes at 11 months used routinely collected data.Results178 out of 244 eligible practices participated. The implementation package reduced risky prescribing (odds ratio 0.82; 97.5% confidence interval 0.67 to 0.99). There was no effect on other primary endpoints.ConclusionThis highly pragmatic, robust evaluation suggests the value of targeting risky prescribing, given predictable population reductions in avoidable morbidity, deaths and hospital admissions. However, in broad terms, an adapted ‘one-size-fits-all’ approach did not consistently work, with no improvement for other targeted indicators.
A randomised controlled trial of a facilitated home-based rehabilitation intervention in patients with heart failure with preserved ejection fraction and their caregivers: REACH-HFpEF pilot study
Authors: Dalal Hasnain M , Lang Chim C , Smith Karen , Wingham Jenny , Eyre Victoria , Greaves Colin J , Warren Fiona C , Green Colin , Jolly Kate , Davis Russell C , Doherty Patrick , Austin Jackie , Britten Nicholas , Abraham Charles , Van Lingen Robin , Singh Sally , Paul Kevin , Hillsdon Melvyn , Sadler Susannah , Hayward Christopher , Taylor Rod S ,   On behalf of the REACH-HF Investigators
Published: June 2018

BackgroundHome-based models of cardiac rehabilitation may overcome suboptimal rates of participation.AimThis study sought to assess the feasibility and acceptability of a novel healthcare professional facilitated home-based comprehensive self-management REACH-HF rehabilitation intervention for patients with heart failure with preserved ejection fraction (HFpEF) and their caregivers.MethodPatients were randomised 1 to the REACH-HF intervention plus usual care (intervention group) or usual care alone (control group). Outcomes were collected at baseline, 3 and 6 months post-randomisation. Outcomes were also collected in caregivers.ResultsWe enrolled 50 symptomatic patients with a left ventricular ejection fraction ≥ 45% (mean age: 73.9 years, 54% female: 96% in NYHA II/III) and 21 caregivers. Study retention (90%) and intervention uptake (92%) were excellent. At 6 months, a number of patient outcomes showed a potential direction of effect in favour of the intervention group, including the primary outcome of Minnesota Living with Heart Failure Questionnaire total score (between group mean difference: −11.5, 95% confidence interval: −22.8 to 0.3). A total of 11 (4 intervention, 7 control) patients experienced a hospital admission over the 6 months follow up with 4 (all control patients) of these admissions being HF-related. Improvements were seen in a number intervention caregiver mental health and burden compared to control.ConclusionOur findings support the feasibility and rationale for the delivering the REACH-HF facilitated home-based rehabilitation intervention for patients with HFpEF and their caregivers and progression to a full multicentre randomised clinical trial to test the clinical and cost-effectiveness of this novel intervention.
Promotion of HIV testing in primary care in east London through a research programme: an MRC phase IV implementation study
Authors: Leber Werner , Beresford Lee , Nightingale Claire , El-Shogri Farah , McMullen Heather , Boomla Kambiz , Anderson Jane , Creighton Sarah , Millett Danna , Figueroa Jose , Hutchinson Jane , Estcort Claudia , Shahmanesh Maryam , Fulop Naomi , Griffiths Chris 
Published: June 2018

BackgroundHIV remains underdiagnosed. Guidelines recommend routine HIV testing in primary care but evidence on implementing testing is lacking.AimWe aimed to determine the effectiveness of post-trial implementation of a cluster randomised controlled trial (RHIVA2) promoting HIV testing in Hackney general practice.MethodThe RHIVA2 intervention (2010–12) comprised initial education and training, nomination of a practice lead nurse, external quality assurance, and referral of newly diagnosed patients to HIV services. Post-trial implementation (2012–2015) included additional intervention training, and audit of antiretroviral co-prescribing and missed HIV diagnoses. Monthly computerised HIV testing data, remotely extracted by the clinical effectiveness group, were analysed using interrupted time series analysis.ResultsFollowing RHIVA2 (20 intervention and 20 control practices), an additional 12 practices (11 former trial control, one former non-participating) received the intervention, and training was reinforced in six former trial intervention practices; a total of 31 practices (13 former trial intervention, 15 former trial control, and three former non-participating) completed the audit. HIV testing rates in intervention practices (trial or post-trial) increased immediately following the intervention by 85% (IRR = 1.85, 95% CI 1.72 to 1.99), and a similar effect (IRR 1.82, 95% CI 1.72 to 1.93) was observed when including comparator practices that didn’t receive the intervention at any point. The change in the effect of the intervention during the three years following the intervention decreased significantly (IRR = 0.99, 95% CI 0.99 to 0.99).ConclusionPost-trial implementation of a research intervention increased testing activity but may require regular support for sustainability.