bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiota-dependent elevation of Alcohol Dehydrogenase inDrosophilais associated with changes in alcohol-induced hyperactivity and alcohol preference
Authors: Blundon Malachi A. , Park Annie , Keith Scott A. , Oliver Stacie L. , Eutsey Rory A. , Pyzel Anna M. , Lau Tiffany W. , Huang Jennifer H. , Kolev Hannah M. , Luisa Hiller N. , Atkinson Nigel S. , Minden Jonathan S. , McCartney Brooke M. 
Published: October 2018

SummaryThe gut microbiota impacts diverse aspects of host biology including metabolism, immunity, and behavior, but the scope of those effects and their underlying molecular mechanisms are poorly understood. To address these gaps, we used Two-dimensional Difference Gel Electrophoresis (2D-DIGE) to identify proteomic differences in male and femaleDrosophilaheads raised with a conventional microbiota and those raised in a sterile environment (axenic). We discovered 22 microbiota-dependent protein differences, and identified a specific elevation in Alcohol Dehydrogenase (ADH) in axenic male flies. Because ADH is a key enzyme in alcohol metabolism, we asked whether physiological and behavioral responses to alcohol were altered in axenic males. Here we show that alcohol induced hyperactivity, the first response to alcohol exposure, is significantly increased in axenic males, requires ADH activity, and is modified by genetic background. While ADH activity is required, we did not detect significant microbe-dependent differences in systemic ADH activity or ethanol level. Like other animals,Drosophilaexhibit a preference for ethanol consumption, and here we show significant microbiota-dependent differences in ethanol preference specifically in males. This work demonstrates that maleDrosophila’sassociation with their microbiota affects their physiological and behavioral responses to ethanol.
The GBAF chromatin remodeling complex binds H3K27ac and mediates enhancer transcription
Authors: Jefimov Kirill , Alcaraz Nicolas , Kloet Susan L. , Värv Signe , Sakya Siri Aastedatter , Vaagenso Christian Dalager , Vermeulen Michiel , Aasland Rein , Andersson and Robin 
Published: October 2018

AbstractH3K27ac is associated with regulatory active enhancers, but its exact role in enhancer function remains elusive. Using mass spectrometry-based interaction proteomics, we identified the Super Elongation Complex (SEC) and GBAF, a non-canonical GLTSCR1L- and BRD9-containing SWI/SNF chromatin remodeling complex, to be major interactors of H3K27ac. We systematically characterized the composition of GBAF and the conserved GLTSCR1/1L ‘GiBAF’-domain, which we found to be responsible for GBAF complex formation and GLTSCR1L nuclear localization. Inhibition of the bromodomain of BRD9 revealed interaction between GLTSCR1L and H3K27ac to be BRD9-dependent and led to GLTSCR1L dislocation from its preferred binding sites at H3K27ac-associated enhancers. GLTSCR1L disassociation from chromatin resulted in genome-wide downregulation of enhancer transcription while leaving most mRNA expression levels unchanged, except for reduced mRNA levels from loci topologically linked to affected enhancers. Our results indicate that GBAF is an enhancer-associated chromatin remodeler important for transcriptional and regulatory activity of enhancers.Graphical abstract
Multifunction control and evaluation of a 3D printed hand prosthesis with the Myo armband by hand amputees
Authors: Cognolato M. , Atzori M. , Marchesin C. , Marangon S. , Faccio D. , Tiengo C. , Bassetto F. , Gassert R. , Petrone N. , Müller H. 
Published: October 2018

AbstractUpper limb amputations are highly impairing injuries that can substantially limit the quality of life of a person. The most advanced dexterous prosthetic hands have remarkable mechanical features. However, in most cases, the control systems are a simple extension of basic control protocols, making the use of the prosthesis not intuitive and sometimes complex. Furthermore, the cost of dexterous prosthetic hands is often prohibitive, especially for the pediatric population and developing countries. 3D printed hand prostheses can represent an opportunity for the future. Open 3D models are increasingly being released, even for dexterous prostheses that are capable of moving each finger individually and actively rotating the thumb. However, the usage and test of such devices by hand amputees (using electromyography and classification methods) is not well explored. The aim of this article is to investigate the usage of a cost-effective system composed of a 3D printed hand prosthesis and a low-cost myoelectric armband. Two subjects with transradial amputation were asked to wear a custom-made socket supporting the HANDi Hand and the Thalmic Labs Myo armband. Afterwards, the subjects were asked to control and use the prosthetic hand to grasp several objects by attempting to perform a set of different hand gestures. Both the HANDi Hand and the Myo armband performed well during the test, which is encouraging considering that the HANDi Hand was developed as a research platform. The results are promising and show the feasibility of the multifunction control of dexterous 3D printed hand prostheses based on low-cost setups. Factors as the level of the amputation, neuromuscular fatigue and mechanical limitations of the 3D printed hand prosthesis can influence the performance of the setup. Practical aspects such as usability and robustness will need to be addressed for successful application in daily life. A video of the tests can be found at the following link:https://youtu.be/iPSCAbd17Qw
Efficient and reproducible somatic embryogenesis and micro propagation in tomato via novel structures -Rhizoid Tubers
Authors: Saeed Wajeeha , Naseem Saadia , Gohar Daniyal , Ali Zahid 
Published: October 2018

AbstractAn improved and highly reproducible system for invitro regeneration via somatic embryogenesis (S.E), applicable to several varieties of tomato (cv. Riogrande, cv. Roma grande, hybrid 17905 and model cv. M82) has been developed. First, we developed a conventional indirect organogenesis for all four varieties used in this study. The cotyledons and hypocotyls of 6-day-old tomato were used as explants (1-2 cm) for callus induction (CI) on different callus induction media (CIM) T0 – T12 (6-Benzylaminopurine BAP, NAA Naphthalene acetic acid, ZEA Zeatin, IAA Indole-3-acetic acid, KIN Kinetin). Maximum CI response was seen on CIMT6 (0.5 mg/L NAA, 1 mg/L BAP) and CIMT7 (2 mg/L IAA, 2 mg/L NAA, 2 mg/L BAP, 4mg/L KIN) in a period of 2 weeks for commercial varieties cvs. Riogrande and Roma. However, cv. M82 responded after 4 weeks to a combination of treatments [CIMT6 (0.5 mg/L NAA + 1 mg/L BAP) and CIMT8 (2 mg/L IAA + 2 mg/L NAA + 2 mg/L BAP + 4 mg/L ZEA)] for the production of calli. The Riogrande, being the most responsive commercial variety, was selected for invitro morphogenesis via S.E. During S.E. young cotyledons and hypocotyls explants were tested on media with different ranges of pH (3 – 7) supplemented with 0.5 and 2 mg/L NAA. Resultantly, numerous rhizoids (~38) were produced from each explant at pH4 in dark conditions. Further incubation of each rhizoid under light conditions led to the formation of a novel structure - rhizoid tubers (RTBs) on MS media supplemented with 5 mg/L TDZ/BAP at pH4. We observed that only lower pH-induced rhizoids and RTBs regenerated into multiple individual shoots on media at normal pH (5.8). The RTBs led to a complete plantlets regeneration in 45 days compared to the conventional invitro morphogenesis (60 days).
Cytoneme-mediated signaling essential for tumorigenesis
Authors: Fereres Sol , Hatori Ryo , Hatori Makiko , Kornberg Thomas B. 
Published: October 2018

ABSTRACTCommunication between neoplastic cells and cells of their microenvironment is critical to cancer progression. To investigate the role of cytoneme-mediated signaling as a mechanism for distributing growth factor signaling proteins between tumor and tumor-associated cells, we analyzed EGFR and RET Drosophila tumor models. We tested several genetic loss-of-function conditions that impair cytoneme-mediated signaling.diaphanous, Neuroglian, SCAR, capriciousare genes that cytonemes require during normal development. Genetic inhibition of cytonemes restored apical basal polarity to tumor cells, reduced tumor growth, and increased organism survival. These findings suggest that cytonemes traffic the signaling proteins that move between tumor and stromal cells, and that cytoneme-mediated signaling is required for tumor growth and malignancy.SummaryEssential cytonemes for paracrine signaling in Drosophila tumors
Theoretical investigation of stochastic clearance of bacteria: First-passage analysis
Authors: Teimouri Hamid , Kolomeisky Anatoly B. 
Published: October 2018

AbstractUnderstanding mechanisms of bacterial eradication is critically important for overcoming failures of antibiotic treatments. Current studies suggest that the clearance of large bacterial populations proceeds deterministically, while for smaller populations the stochastic effects become more relevant. Here we develop a theoretical approach to investigate the bacterial population dynamics under the effect of antibiotic drugs using a method of first-passage processes. It allows us to explicitly evaluate the most important characteristics of the bacterial clearance dynamics such as extinction probabilities and extinction times. The new meaning of minimal inhibitory concentrations for stochastic clearance of bacterial populations is also discussed. In addition, we investigate the effect of fluctuations in the population growth rates on dynamics of bacterial eradication. It is found that extinction probabilities and extinction times generally do not correlate with each other when random fluctuations in the growth rates are taking place. Unexpectedly, for a significant range of parameters the extinction times increase due to these fluctuations, indicating a slowing in the bacterial clearance dynamics. It is argued that this might be one of the initial steps in the pathway for the development of antibiotic resistance. Furthermore, it is suggested that extinction times is a convenient measure of bacterial tolerance.
Design and analysis of a feedback loop to regulate the basic parameters of the unmanned aircraft
Authors: Chodnicki Marcin , Bartnik Katarzyna , Nowakowski Miroslaw , Kowaleczko Grzegorz 
Published: October 2018

Purpose
The motivation to perform research on feedback control system for unmanned aerial vehicles, a fact that each quadrocopter is unstable.

Design/methodology/approach
For this reason, it is necessary to design a control system which is capable of making unmanned aerial vehicle vertical take-off and landing (UAV VTOL) stable and controllable. For this purpose, it was decided to use a feedback control system with cascaded PID controller. The main reason for using it was that PID controllers are simple to implement and do not use much hardware resources. Moreover, cascaded control systems allow to control object response using more parameters than in a standard PID control. STM32 microcontrollers were used to make a real control system. The rapid prototyping using Embedded Coder Toolbox, FreeRTOS and STM32 CubeMX was conducted to design the algorithm of the feedback control system with cascaded PID controller for unmanned aerial vehicle vertical take-off and landings (UAV VTOLs).

Findings
During research, an algorithm of UAV VTOL control using the feedback control system with cascaded PID controller was designed. Tests were performed for the designed algorithm in the model simulation in Matlab/Simulink and in the real conditions.

Originality/value
It has been proved that an additional control loop must have a full PID controller. Moreover, a new library is presented for STM32 microcontrollers made using the Embedded Coder Toolbox just for the research. This library enabled to use rapid prototyping while developing the control algorithms.
Distributed task allocation for multiple heterogeneous UAVs based on consensus algorithm and online cooperative strategy
Authors: Wu Weinan , Cui Naigang , Shan Wenzhao , Wang Xiaogang 
Published: October 2018

Purpose
The purpose of this paper is to develop a distributed task allocation method for cooperative mission planning of multiple heterogeneous unmanned aerial vehicles (UAVs) based on the consensus algorithm and the online cooperative strategy.

Design/methodology/approach
In this paper, the allocation process is conducted in a distributed framework. The cooperative task allocation problem is proposed with constraints and uncertainties in a real mission. The algorithm based on the consensus algorithm and the online cooperative strategy is proposed for this problem. The local chain communication mode is adopted to restrict the bandwidth of the communication link among the UAVs, and two simulation tests are given to test the optimality and rapidity of the proposed algorithm.

Findings
This method can handle both continuous and discrete uncertainties in the mission space, and the proposed algorithm can obtain a feasible solution in allowable time.

Research limitations/implications
This study is only applied to the case that the total number of the UAVs is less than 15.

Practical implications
This study is expected to be practical for a real mission with uncertain targets.

Originality/value
The proposed algorithm can go beyond previous works that only deal with continuous uncertainties, and the Bayesian theorem is adopted for estimation of the target.
Photographs as documents/photographs as objects: photo archives, art history and the material approach
Authors: Caraffa Costanza 
Published: October 2018

Purpose
This paper aims at demonstrating how the material approach questions conventional hierarchies of photographic value, showing a way to deal with large quantities of photographs accumulated by scientific and scholarly disciplines in their archives.

Design/methodology/approach
For generations, these photographs have been considered as pure documentations of the objects represented in them (from artworks in museums to snowflakes under a microscope). Documentary photographs have been understood as mere working tools that can now be easily replaced by digital duplicates. Overcoming the long-established reduction of photographs to their visual content, the material approach shifts attention to masses of anonymous photographs that are often disregarded within institutions because they do not match museum systems of value based on uniqueness and authorship.

Findings
Focussing on photographic and archival practices in art history, this paper aims at demonstrating how conceptual and methodological tools such as “agency” and “materiality” can be made fruitful for theory and practice of photo archives able to explore their epistemological potential. A case study from the Photothek of the Kunsthistorisches Institut in Florenz allows an insight into historical and contemporary dynamics and practices of photographic archives.

Originality/value
With its interwoven strands of archival practice and academic research, the Photothek unboxes itself as a laboratory for the international, cross-disciplinary debate on the role and function of photographs and photographic archives in scholarship, suggesting a methodological path for the entire field. In conclusion, the paper shows that the first necessary step for a long-term conservation of photo archives is promoting research on the photographic objects.
Do work-life balance practices mediate in the relationship between female participation and financial performance?
Authors: Odriozola María Dolores , Baraibar-Diez Elisa 
Published: October 2018

PurposeThe purpose of this paper is to analyse the relationship between the participation of women in companies with financial performance. However, this relationship does not arise directly. The authors argue that the participation of women in the company’s staff has a positive effect on the creation of work-life balance (WLB) practices, due to women have traditionally assumed family responsibilities, and subsequently these practices positively affect financial performance. WLB practices are a tool to balance employees’ professional and personal goals.Design/methodology/approachThis study aims to determine whether WLB practices mediate in the relationship between female participation in the workforce and financial performance on large companies listed in the Spanish Stock Exchange Index during the period from 2008 to 2013.FindingsThe main finding is that female participation in the workforce positively affects to the availability of WLB practices, but WLB practices are not a mediator to increase financial performance.Originality/valueThe study is a new contribution for academics and practitioners, since the WLB has a role of moderating variable; and the positive joint effect of female participation and WLB practices is tested over the company’s outcomes, instead of over the individual employee behaviour like in previous literature. In addition, this effect is studied in a country with economic recession where corporate WLB practices have increased in the last decade.
Talent management process in Asia: a multiple case study
Authors: Li Jessica , Hedayati-Mehdiabadi Amir , Choi Jeonghwan , Wu Feng , Bell Allison 
Published: October 2018

Purpose
The purpose of this study is to examine talent management process in a region that has been influenced by Eastern culture.

Design/methodology/approach
This research is a multiple case study of six MNCs in Asia. Cross-cases analysis was used to reveal differences and similarities. The data were collected through phone interviews with HR managers and written communications as well as organizations’ websites.

Findings
The studied companies were dealing with several challenges regarding talent management process, including challenges of attracting and retaining talent, tension between subsidiaries and headquarters, tension between high potentials and non-high potentials and tension between generations. These companies’ strategies for addressing these challenges were also identified and discussed.

Originality/value
This paper revealed talent management orientation, the approach toward and definition of talent and context-specific issues regarding talent management of the selected companies in a region in which this topic has not been sufficiently studied in the past.
Effect of MHD on the flow and heat transfer characteristics of nanofluid in a grooved channel with internal heat generation
Authors: Dehghani Mohammad Sadegh , Toghraie Davood , Mehmandoust Babak 
Published: October 2018

Purpose
The purpose of this study is numerical simulation of magnetohydrodynamics (MHD) water–Al2O3 nanofluid mixed convection in a grooved channel with internal heat generation in solid cylinders. Simulations were carried out at Reynolds numbers 50 ≤ Re ≤ 100, Hartmann numbers 0 ≤ Ha ≤ 15, Grashof numbers 5,000 ≤ Gr ≤ 10−4 and volume fraction 0 ≤ φ ≤ 0.04. The effect of Reynolds number and the influence of magnetic field and pressure drop on convective heat transfer coefficient were studied in different volume fractions of nanoparticles at different Reynolds numbers.

Design/methodology/approach
The results show that average Nusselt number increases by increasing Reynolds and Hartman numbers. Also, when Hartman number increases, velocity profile becomes asymmetric. Pressure distribution shows that magnetic field applies Lorentz force at opposite direction of the flow, which causes asymmetric distribution of pressure. As a result, pressure in the upper half of the cylinder is higher than the lower half. Finally, velocity and temperature contours along the channel for different Hartmann numbers, volume fraction 3 per cent, Re = 50 and 100 and Gr = 10,000, are presented.

Findings
The effect of Reynolds number and the influence of magnetic field and pressure drop on convective heat transfer coefficient were studied in different volume fractions of nanoparticles at different Reynolds numbers.

Originality/value
Effect of MHD on the flow and heat transfer characteristics of Water–Al2O3 nanofluid in a grooved channel with internal heat generation in solid cylinders.
Magneto-hydrodynamic natural convection of CuO-water nanofluid in complex shaped enclosure considering various nanoparticle shapes
Authors: Dogonchi A.S. , Selimefendigil F. , Ganji D.D. 
Published: October 2018

Purpose
The purpose of this study is to peruse natural convection in a CuO-water nanofluid-filled complex-shaped enclosure under the influence of a uniform magnetic field by using control volume finite element method.

Design/methodology/approach
Governing equations formulated in dimensionless stream function, vorticity and temperature variables using the single-phase nanofluid model with the Koo–Kleinstreuer–Li correlation for the effective dynamic viscosity and the effective thermal conductivity have been solved numerically by control volume finite element method.

Findings
Effects of various pertinent parameters such as Rayleigh number, Hartmann number, volume fraction of nanofluid and shape factor of nanoparticle on the convective heat transfer characteristics are analysed. It was observed that local and average heat transfer rates increase for higher value of Rayleigh number and lower value of Hartmann number. Among various nanoparticle shapes, platelets were found to be best in terms of heat transfer performance. The amount of average Nusselt number reductions was found to be different when nanofluids with different solid particle volume fractions were considered due to thermal and electrical conductivity enhancement of fluid with nanoparticle addition.

Originality/value
A comprehensive study of the natural convection in a CuO-water nanofluid-filled complex-shaped enclosure under the influence of a uniform magnetic field by using control volume finite element method is addressed.
Heat transfer enhancement in solidification process by change of fins arrangements in a heat exchanger containing phase-change materials
Authors: Hosseini Mohammad M. , Rahimi Asghar B. 
Published: October 2018

Purpose
Reducing discrepancy between energy demand and supply has been a controversial issue among researchers. Thermal energy storage is a technique to decrease this difference to increase the thermal efficiency of systems. Latent heat thermal energy storage has interested many researchers over the past few decades because of its high thermal energy density and constant operating temperature. The purpose of this paper is to provide a numerical study of the solidification process in a triplex tube heat exchanger containing phase change material (PCM) RT82.

Design/methodology/approach
A two-dimensional transient model was generated using finite volume method and regarding enthalpy-porosity technique. After that, a detailed and systematic approach has been presented to modify longitudinal fins’ configuration to enhance heat transfer rate in PCMs and reducing solidification time. The numerical results of this study have been validated by reference experimental results.

Findings
The ultimate model reduced solidification time up to 21.1 per cent of the Reference model which is a substantial improvement. Moreover, after testing different arrangements of rectangular fins and studying the flow pattern of liquid PCM during solidification, two general criteria was introduced so that engineers can reach the highest rate of heat transfer for a specified value of total surface area of fins. Finally, the effect of considering natural convection during solidification was studied, and the results showed that disregarding natural convection slows down the solidification process remarkably in comparison with experimental results and in fact, this assumption generates non-real estimation of solidification process.

Originality/value
The arrangement of the fins to have the best possible solidification time is the novelty in this paper.