bluuebunny/crossref_metadata_2025_split huggingface dataset:
B7-H3-targeted Radioimmunotherapy of Human Cancer
Authors: Kasten Benjamin B. , Ferrone Soldano , Zinn Kurt R. , Buchsbaum Donald J. 
Published: March 2019

Background:
Targeted Radioimmunotherapy (RIT) is an attractive approach to selectively
localize therapeutic radionuclides to malignant cells within primary and metastatic
tumors while sparing normal tissues from the effects of radiation. Many human malignancies
express B7-H3 on the tumor cell surface, while expression on the majority of normal tissues is
limited, presenting B7-H3 as a candidate target for RIT. This review provides an overview of
the general principles of targeted RIT and discusses publications that have used radiolabeled
B7-H3-targeted antibodies for RIT of cancer in preclinical or clinical studies.

Methods:
Databases including PubMed, Scopus, and Google Scholar were searched for publications
through June 2018 using a combination of terms including “B7-H3”, “radioimmunotherapy”,
“targeted”, “radiotherapy”, and “cancer”. After screening search results for relevancy,
ten publications were included for discussion.

Results:
B7-H3-targeted RIT studies to date range from antibody development and assessment
of novel Radioimmunoconjugates (RICs) in animal models of human cancer to phase
II/III trials in humans. The majority of clinical studies have used B7-H3-targeted RICs for intra-
compartment RIT of central nervous system malignancies. The results of these studies
have indicated high tolerability and favorable efficacy outcomes, supporting further assessment
of B7-H3-targeted RIT in larger trials. Preclinical B7-H3-targeted RIT studies have also
shown encouraging therapeutic outcomes in a variety of solid malignancies.

Conclusion:
B7-H3-targeted RIT studies over the last 15 years have demonstrated feasibility
for clinical development and support future assessment in a broader array of human malignancies.
Future directions worthy of exploration include strategies that combine B7-H3-
targeted RIT with chemotherapy or immunotherapy.
Screening of Anti-mycobacterial Phytochemical Compounds for Potential Inhibitors against Mycobacterium Tuberculosis Isocitrate Lyase
Authors: Tiwari Ashish , Kumar Akhil , Srivastava Gaurava , Sharma Ashok 
Published: March 2019

Conclusion:Phytochemical based anti-mycobacterial compound can further developed into effective drugs against persistence tuberculosis with lesser toxicity and side effects.Results:Docking and MD simulation studies of top hit compounds have identified shinjudilactone (quassinoid), lecheronol A (pimarane) and caniojane (diterpene) as potential MtbICL inhibitors.Methods:Virtual screening, molecular docking and MD simulation study has been integrated for screening of phytochemical based anti-mycobacterial compounds. Docking study of reported MtbICL inhibitors has shown an average binding affinity score -7.30 Kcal/mol. In virtual screening, compounds exhibiting lower binding energy than calculated average binding energy were selected as top hit compounds followed by calculation of drug likeness property. Relationship between experimental IC50 value and calculated binding gibbs free energy of reported inhibitors was also calculated through regression analysis to predict IC50 value of potential inhibitors.Background and Introduction:Tuberculosis (TB) is a leading infectious disease caused by Mycobacterium tuberculosiswith high morbidity and mortality. Isocitrate lyase (MtbICL), a key enzyme of glyoxylate pathway has been shown to be involved in mycobacterial persistence, is attractive drug target against persistent tuberculosis.
Psychosocial Risk Factors and Ischemic Heart Disease: A New Perspective
Authors: Roncella Adriana 
Published: March 2019

Background:
Cardiovascular disease is the most common cause of morbidity and mortality
worldwide, with ischemic heart disease (IHD) accounting for roughly 50% of these events in industrialized
nations.

:
In recent years, the relative importance of IHD in less industrialized countries is also rising at an
alarming and steadily-increasing rate.

Objective:
Many experimental, observational and epidemiological studies have demonstrated the
importance of psychosocial risk factors in the development and clinical manifestations of IHD. They
act both indirectly, associated with an unhealthy lifestyle; and directly, through the activation of inflammatory
cascades and the sympathetic nervous system. They also cluster with biological risk factors
to increase the incidence and clinical manifestations of IHD. From these assumptions, there
emerges the potential that an integrated approach that incorporates psychological therapy in various
forms might reduce IHD patients’ symptoms and maladaptive behaviors, and thereby enhance their
prognosis.

Methods:
To date, three psychotherapeutic approaches have been utilized within cardiac psychology
practice: (1) cognitive-behavioral psychotherapy; (2) psychodynamic psychotherapy; and (3) ontopsychological
psychotherapy. The current article briefly describes these three approaches and how
their use might enhance the care of IHD patients.

Results:
A range of psychological characteristics influence the development, course and management
of cardiac patients’ IHD. Among others, these include patients’ emotions, attitudes, behaviors, relationships,
and stressors. State-of- the-art literature suggests that psychological interventions should
be considered in much the same way as medical interventions, in terms of their relevance to both patient
management and outcomes.

Conclusion:
For this reason, it is essential that professional psychological and psychotherapeutic
support be rendered available to cardiology patients, as a means to enhance both the effectiveness
and efficiency of care.
Psychotropic Medication of Acute Episodes of Mood Disorders: Current Prescription Attitude in Two Psychiatric Wards in Cagliari, Italy
Authors: Baggiani Gioia , Ambrosiani Luca , Trincas Pierfranco , Burrai Caterina , Bocchetta Alberto 
Published: March 2019

Background:Medication of acute episodes of mood disorders has changed over the last decades following the results of randomized clinical trials.Objective:The aim of this study was to analyze medication prescribed at discharge from two psychiatric wards. We focused on hospitalization as one of the best opportunities to start prophylaxis.Methods:We examined retrospectively the clinical records of 357 patients hospitalized for mood episodes in two psychiatric wards in the Cagliari area (SPDC-1 and SPDC-2) between 1 January and 31 December 2016. We focused on the psychotropic medication prescribed at discharge from the hospital.Results:Most patients were discharged with antipsychotics (86%) and/or benzodiazepines (89%). Combined medication was frequent, including various co-administration of first-generation and/or second-generation antipsychotics (26% of patients), or antipsychotics combined with mood-stabilizers (51% of patients). There was a preferential prescription of first-generation antipsychotics in SPDC-1, and of second-generation antipsychotics in SPDC-2. Prescription of lithium was significantly more frequent in SPDC-1.Conclusion:Although the treatment was in line with randomized clinical trials, the choice of individual psychotropic agents differed significantly between the two wards. Different prescription attitudes can have consequences on the long-term outcome of patients discharged from the hospital after an acute mood episode.
Synthesis and Characterization of Valacyclovir HCl Hybrid Solid Lipid Nanoparticles by Using Natural Oils
Authors: Chacko Archana , Newton Amaldoss M.J. 
Published: March 2019

Background:
The Jojoba Simmondsia Chinensis oil is used as one of the main ingredients
which has an antioxidant, moisturizing and stabilizing activity. Likewise, grape seed (Vitis vinifera) oil
is also used in this preparation which also has some remarkable medicinal properties such as antioxidant,
astringent and is also used as a moisturizer. The Valacyclovir Solid Lipid Nanoparticles (SLN)
are prepared in combination.

Objective:
The prime objective of the study was to prepare a nanodispersion with good stability indicating
zeta potential. The formulations were prepared by varying concentrations of jojoba oil and grape
seed oil which form the hybrid nanoparticles with the drug.

Methods:
The high-pressure hot-homogenization technique was used to prepare the nanoparticles. The
prepared nanoparticles were subjected to characterization analysis such as Mean particle size, Zaverage,
and Zeta potential by using Dynamic Light Scattering (DLS) and Photon Correlation Spectroscopy
(PCS). The best formulation was subjected to Transmission Electron Microscopy (TEM)
technique for surface morphology and other characterizations. The crystalline pattern of the drug alone,
drug-loaded nanoparticles and nanoparticles without the drug was studied by XRD. The drug excipients
compatibility studies were performed by using Fourier-Transform Infrared Spectroscopy (FTIR)
Differential Scanning Calorimetry and (DSC). The other factors such as in vitro drug release, and %
drug entrapment efficiency were studied by using suitable methods.

Results:
The results demonstrated that the particles are in nano range with good stability with appreciable
Zeta potential (-48.2±mV). The selected formulations were analyzed for MPS which demonstrated
the value of 306.7±183.4 and 416.5±289.3. The best formulation VNP5 demonstrated the Bellshaped
curve and confirmed the uniform distribution.

Conclusion:
Based on the patents, it was demonstrated that valacyclovir is widely used in the treatment
and prophylaxis of viral infections in human, particularly infections caused by the herpes group
of viruses. Valacyclovir is an effective drug for the treatment of cold sores.
How New Technologies Can Improve Prediction, Assessment, and Intervention in Obsessive-Compulsive Disorder (e-OCD): Review
Authors: Ferreri Florian , Bourla Alexis , Peretti Charles-Siegfried , Segawa Tomoyuki , Jaafari Nemat , Mouchabac Stéphane 
Published: March 2019

Background
New technologies are set to profoundly change the way we understand and manage psychiatric disorders, including obsessive-compulsive disorder (OCD). Developments in imaging and biomarkers, along with medical informatics, may well allow for better assessments and interventions in the future. Recent advances in the concept of digital phenotype, which involves using computerized measurement tools to capture the characteristics of a given psychiatric disorder, is one paradigmatic example.

Objective
The impact of new technologies on health professionals’ practice in OCD care remains to be determined. Recent developments could disrupt not just their clinical practices, but also their beliefs, ethics, and representations, even going so far as to question their professional culture. This study aimed to conduct an extensive review of new technologies in OCD.

Methods
We conducted the review by looking for titles in the PubMed database up to December 2017 that contained the following terms: [Obsessive] AND [Smartphone] OR [phone] OR [Internet] OR [Device] OR [Wearable] OR [Mobile] OR [Machine learning] OR [Artificial] OR [Biofeedback] OR [Neurofeedback] OR [Momentary] OR [Computerized] OR [Heart rate variability] OR [actigraphy] OR [actimetry] OR [digital] OR [virtual reality] OR [Tele] OR [video].

Results
We analyzed 364 articles, of which 62 were included. Our review was divided into 3 parts: prediction, assessment (including diagnosis, screening, and monitoring), and intervention.

Conclusions
The review showed that the place of connected objects, machine learning, and remote monitoring has yet to be defined in OCD. Smartphone assessment apps and the Web Screening Questionnaire demonstrated good sensitivity and adequate specificity for detecting OCD symptoms when compared with a full-length structured clinical interview. The ecological momentary assessment procedure may also represent a worthy addition to the current suite of assessment tools. In the field of intervention, CBT supported by smartphone, internet, or computer may not be more effective than that delivered by a qualified practitioner, but it is easy to use, well accepted by patients, reproducible, and cost-effective. Finally, new technologies are enabling the development of new therapies, including biofeedback and virtual reality, which focus on the learning of coping skills. For them to be used, these tools must be properly explained and tailored to individual physician and patient profiles.
Role of taste perception in white spot lesion formation during orthodontic treatment
Authors: Alanzi Abrar , Velissariou Marianna , Al-Melh Manal Abu , Ferguson Donald , Kavvadia Katerina 
Published: March 2019

ABSTRACT

Objectives:
To investigate the role of individual's taste sensitivity using 6-n-propylthiouracil (PROP) in the development of white spot lesions (WSLs) in adolescent orthodontic patients.

Materials and Methods:
44 healthy adolescents, aged 12 to 16 years old, who were in fixed-appliance orthodontic treatment for at least 6 months, consented to participate in this cross-sectional study. Data regarding participants' demographic information, oral hygiene practices, and dietary habits were obtained by a questionnaire. An oral clinical examination was performed to determine the oral hygiene status, the presence of WSLs and dental caries experience. The taste phenotype of the participants was evaluated through PROP test and they were accordingly divided into PROP nontasters and PROP tasters.

Results:
The sample consisted of 24 subjects in the WSL group and 20 subjects in the WSL-free group. The WSL group demonstrated higher mean plaque score (48.2), mean decayed, missing, and filled surfaces (2.38), and mean decayed, missing, and filled teeth (1.96) scores compared to the WSL-free group (38.7, 0.85, and 0.55, respectively), but no significant differences were found. Most subjects in the WSL group were PROP nontasters (66.6%) whereas most subjects in the WSL-free group were PROP tasters (75%); a significant difference was observed between the groups (P = .006).

Conclusions:
The prevalence of white spot lesions was significantly higher in adolescent orthodontic patients who were PROP nontasters compared to PROP tasters. A PROP taste perception could be a potential risk factor for the formation of WSLs during fixed orthodontic treatment that warrants further attention.
PENATAAN RUANG HALTE TRANS JOGJA DI BANDARA ADISUCIPTO YANG BERBASIS ERGONOMI DENGAN PROGRAM THE SIMS 3
Authors: Anggraeni Dhita Wahyu 
Published: March 2019

Trans Jogja Shelter in Yogyakarta Adisucipto airport is one of the shelters, which is in great public demand, because it integrates with other transport modes. The airport bus shelter is full of passengers with different human dimensions and their luggage. Based on initial observations about movement circulation during rush hour, it was found such difficulties in movement system and led to insecurity for the passengers. The purpose of this study is to analyze the circulation layout based on ergonomic needs at the Trans Jogja shelter in Adisucipto Airport area, which may contributes to the circulation moving system. Criteria of the study are four aspects, i.e the anthropometric, kinetic, physiology, and psychology. This study used behavioral mapping and simulation methods. The Sims 3 program is used for the simulation of human movement in the shelter. The analysis found that the shelter does not meet the need of standard dimensional human motion. In order to improve the quality of a better layout of the shelters, the ergonomic movement system is indispensable to be taken into consideration.Keywords: circulation space, ergonomics, The Sims 3 programAbstrak: Halte Trans Jogja di Bandara Adisucipto Yogyakarta adalah salah satu halte yang banyak dibutuhkan oleh masyarakat karena terintegrasinya berbagai jalur tranportasi yang memberi kemudahan bagi masyarakat dalam memilih tujuan perjalanan. Halte bandara dipenuhi oleh calon penumpang bus dengan bermacam dimensi ukuran tubuh dan barang bawaan. Berdasarkan pengamatan awal ditemukan permasalahan sirkulasi dan gerak terutama pada saat kondisi jam sibuk, banyaknya pengguna halte menyebabkan kesulitan bergerak dan mengakibatkan rasa tidak aman bagi calon penumpang bus. Tujuan penelitian ini adalah mengkaji permasalahan ergonomi pada tata ruang sirkulasi Halte Trans Jogja di Bandara Adisucipto melalui studi gerak sesuai ergonomi. Hasil kajian memberi konstribusi terhadap kenyamanan gerak bagi pengguna halte khususnya masyarakat Yogyakarta. Tolok ukur dalam penelitian ada empat aspek yaitu anthropometri, kinetik, fisiologi dan psikologi. Metode yang digunakan dalam penelitian ini adalah dengan metode pemetaan perilaku (behavioral mapping) dan metode simulasi dengan menggunakan program The Sims 3 yaitu simulasi alur pergerakan manusia di dalam halte. Dari hasil analisis ditemukan bahwa halte yang sekarang tidak memenuhi standar kebutuhan dimensi gerak manusia, maka untuk meningkatkan kualitas halte yang ergonomis dibutuhkan penataan sirkulasi yang lebih baik.Kata kunci: tata ruang sirkulasi, ergonomi, program The Sims 3
TANTANGAN PELESTARIAN DAN PERUBAHAN TERHADAP MANFAAT RUANG TRADISIONAL AKIBAT PENGARUH KEGIATAN INDUSTRI RUMAH TANGGA; STUDI KASUS : RUMAH TINGGAL TRADISIONAL KUDUS
Authors: Tarigan Riandy 
Published: March 2019

Abstrak: Perkembangan kegiatan industri kecil dan rumah tangga serta kegiatan perdagangan sangat pesat sebagai upaya masyarakat dalam memenuhi kebutuhan hidup. Kegiatan tersebut dilakukan di dalam rumah tangga karena keterbatasan modal untuk menyewa tempat untuk kegiatan industri dan perdagangan. Rumah tinggal tradisional merupakan rumah dengan berbagai konsep tradisi yang turun temurun yang diwujudkan kedalam tata ruang dan bentuk bangunan. Kebudayaan awal mula rumah sebagai fungsi hunian untuk berlindung serta sebagai citra dari nilai sosial dan budaya telah berkembang dan berubah menjadi kegiatan ekonomi-produktif. Perkembangan ini merupakan fenomena evolutif yang menarik karena berpengaruh ke dalam sistem tata ruang tradisional yang berkaitan dengan guna dan citra. Kegunaan terkait dengan perubahan fungsi dan tata ruang tradisional dan citra ruang yang diwujudkan ke dalam makna tata letak ruang tersebut terkait dengan kebudayaan. Kajian ini diarahkan kepada penelitian terhadap rumah yang mempunyai ciri tradisional yang telah berkembang kegiatan industri. Dengan tumbuhnya kegiatan industri, secara hipotesis akan terjadi perubahan fungsi dan makna ruang untuk menyesuaikan kebutuhan terhadap kegiatan industri tersebut. Penelitian ini untuk melihat tantangan perubahan cara pandang masyarakat terhadap makna rumah tradisional dan bagaimana penghuni mengantisipasi makna tradisional tersebut ke dalam perubahan tata ruang sebagai akibat dari adanya kegiatan industri didalamnya. Metode penelitian adalah metode deskriptif-kualitatif dengan melakukan indepth interview terhadap penghuni rumah tradisional di Kudus yang terdapat kegiatan industri dan perdagangan didalamnya. Analisa dilakukan dengan membandingkan melalui peta perubahan fungsi ruang saat ini dengan makna ruang tradsioan masa lalu. Dari analisa ini akan ditetapkan mana ruang yang mempunyai sifat dan kedudukan pola ruang tradisional yang tetap dan yang telah berubah. Penelitian ini bertujuan untuk mendapatkan temuan bagaimana konflik antara perubahan kegiatan yang terjadi dalam rumah sekaligus tantangan terhadap upaya untuk melestarikan ruang tradisional tersebut yang diwujudkan dalam penataan ruang.Kata kunci : perubahan, pelestarian, ruang tradisional, kegiatan industri dan perdagangan, Kota Kudus.
‘DISPLACEMENT’, KRITERIA DEKONSTRUKSI PETER EISENMAN
Authors: Mubarrok Noor Zakiy 
Published: March 2019

Abstract: The implementation of deconstruction in architecture presents an extraordinary building, that no rarely lob the name of the designer, no exception for an American architect and theorists, Peter Eisenman. ‘Displacement’ is the notion of Peter Eisenman contains some criteria to implement deconstruction in architecture. The purpose of this research is to explore the thoughts and views of Peter Eisenman about deconstruction in architecture, especially about the notion of ‘displacement’, and its application in the design.Keywords: architecture deconstruction, displacement, peter eisenman Abstrak: Penerapan dekonstruksi dalam arsitektur, menghasilkan karya arsitektur yang luar biasa, yang tak jarang melambungkan nama perancangnya, tak terkecuali Peter Eisenman, seorang arsitek dan teoritikus kebangsaan Amerika. Displacement, merupakan ide yang dicetuskan Peter Eisenman berisi kriteria-kriteria yang harus dipenuhi sebagai upaya menerapkan dekonstruksi dalam arsitektur. Tujuan dari penelitian ini adalah untuk mengeksplorasi pemikiran serta pandangan Peter Eisenman tentang dekonstruksi dalam arsitektur terutama tentang ide Displacement, serta aplikasinya pada rancangan.Kata kunci: dekonstruksi dalam arsitektur, displacement, peter eisenman
SETING ALAMI SEBAGAI SARANA ANAK UNTUK MENGATASI TEKANAN LINGKUNGAN DI KAMPUNG KOTA
Authors: Sativa Sativa , Setiawan Bakti , Wijono Djoko , Adiyanti MG 
Published: March 2019

Abstract: Nowadays, the majority of Indonesian people live in the dense urban kampungs. Some of those kampungs laid on the riverside, as a marginal area -- due to their low economic value of the land. They have specific conditions especially on the limitation of infrastructures and facilities for children activities in the settlement area. This research is a part of my dissertation paper, which aims to gain how children (mainly school-age children) coping with such condition. This study is a qualitative exploratory research, meanwhile, observation and interview were used as collecting data methods. Kampung Ngampilan in Yogyakarta, Indonesia, was chosen as a case area, because of its unique characteristics: located on the riverside of Winongo River, had a high density, and most people have low economics. As the result, this study found that natural setting, especially river area and its surrounding vegetation, is a focus location for children to release live stress in their settlement, due to two space aspects: thermal comfort and visual comfort. This condition was triggered by the limited area of their house so that the children prefer to go out from their house especially after attending school in the afternoon. This results will be useful as a reference for urban kampung planning, especially in riverfront area.Keywords: children, kampung, environmental press, natural settingAbstrak: Mayoritas penduduk kota Indonesia tinggal di kampung berkepadatan tinggi. Sebagian dari kampung -kampung berada di bantaran sungai sebagai salah satu area kota yang dianggap marginal karena nilai ekonomi lahan rendah. Kampung-kampung umumnya berkondisi khas dan memiliki keterbatasan infrastruktur termasuk fasilitas untuk kegiatan anak-anak di permukiman. Studi ini merupakan bagian dari disertasi penulis, yang bertujuan mengetahui bagaimana anak-anak (terutama anak usia sekolah dasar) menghadapi tekanan lingkungan. Kampung Ngampilan dipilih karena merupakan kampung kota yang sangat padat, terletak di tepi sungai, berkontur curam, dan warganya termasuk kelompok ekonomi menengah ke bawah. Kajian ini menggunakan metode kualitatif eksploratif, dan penggalian data dilakukan dengan metode observasi lapangan dan wawancara. Penelitian menemukan, seting alami kampung, khususnya sungai dan vegetasi di sekitarnya, merupakan area pilihan utama anak bermain, karena memiliki dua aspek kenyamanan, yaitu kenyamanan termal dan kenyamanan visual. Pilihan anak-anak dipicu oleh kondisi rumah mereka yang sempit, sehingga mereka lebih memilih keluar rumah sepulang sekolah atau sore hari. Temuan ini dapat menjadi acuan bagi pengembangan kampung kota Indonesia yang lebih kondusif untuk anak, khususnya kampung tepi sungai.Kata kunci: seting alami, tekanan lingkungan, kampung kota, anak