bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Tablet App Supporting Self-Management for People With Dementia: Explorative Study of Adoption and Use Patterns
Authors: Øksnebjerg Laila , Woods Bob , Ruth Kathrine , Lauridsen Annette , Kristiansen Susanne , Holst Helle Dalsgaard , Waldemar Gunhild 
Published: September 2019

Background
Assistive technology (AT) is rapidly emerging within dementia care and support. One area of AT application is support of people with dementia in compensating for cognitive symptoms and thereby promoting their self-management. There is, however, little evidence for the applicability, usability, and effectiveness of AT for people with dementia, and there is a need to identify factors that can promote adoption.

Objective
This study aimed to (1) evaluate the applicability and usability of an app, tailor-made for people with dementia; (2) explore factors affecting adoption; (3) explore the possible influence of caregiver involvement; and (4) contribute to process evaluation of the intervention.

Methods
The ReACT (Rehabilitation in Alzheimer's disease using Cognitive support Technology) app was designed as a holistic solution to support memory and structure in daily living. Persons with dementia had access to a personal user account, and family caregivers were given a parallel login. Written and Web-based materials were provided to support self-applied implementation. A mixed methods design was applied to explore adoption and use patterns, including background and disease-related data, qualitative data from a survey, and log data. Adoption was defined as the use of the app over a period of ≥90 days.

Results
Data from 112 participants and 98 caregivers were included. Shorter time from diagnosis (U=595; P=.046; r=0.19) and caregiver activating the app (P=.02) had a significant impact on the participant adoption status. Logistic regression analysis showed that if caregivers had activated the app, the participant was five times more likely to become an adopter (odds ratio 5.1, 95% CI 1.29-19.99; P=.02). However, the overall predictive power was low, and there was a wide variation in background and disease-related characteristics among adopters. The level of experience and skills in tablet use were not significantly different between adopters and nonadopters. Adopters generally rated the app high on usefulness, satisfaction, and ease of use (rated on the USEdem questionnaire). Their scores were significantly higher compared with nonadopters (U=5.5; P=.02; r=0.64). Analysis of use patterns showed that all functionalities of the app were used among adopters.

Conclusions
For participants who became adopters, the ReACT app and the methods for self-applied implementation were applicable. However, the results were also in accordance with the well-known challenges of nonadoption and nonadherence to digital health interventions. The study provided insight into the importance of timely introduction and caregiver support for adoption of AT among people with dementia. It also underlined the high complexity of personal and contextual factors that influence adoption. These complex factors need to be considered when designing and implementing AT for people with dementia.
A Parenting Behavior Intervention (the Strengthening Families Program) for Families: Noninferiority Trial of Different Program Delivery Methods
Authors: Kumpfer Karol Linda , Brown Jaynie Litster 
Published: September 2019

Background
The Strengthening Families Program (SFP) is an evidence-based parent training and youth life skills and drug prevention program traditionally delivered in group settings. Families attend parent and youth classes conducted by trained facilitators. Recently, a 2-disk home-use DVD series was created with the same SFP skills as the group classes for parents and the youth to watch together at home. Additional lesson material was added that included healthy brain development, school success, anger management, dangers of alcohol and drugs, and mindfulness. The SFP DVD reduces SFP delivery costs for agencies and logistic burdens to families. Creative applications of the DVD include holding SFP DVD family discussion groups of multiple families and using SFP DVD video clips as part of a shorter 10-week group class version for parents and the youth.

Objective
This study aimed to examine three different DVD implementation scenarios using a noninferiority trial, contrasting target outcomes with an age-matched sample culled from a national norm database of families who completed a standard SFP 14-week class.

Methods
The partial eta-square was used to compare effect sizes between the different delivery modalities for relevant programmatic outcomes. We adjusted the effect sizes by demographic measures to determine whether there were site-specific features influencing program outcomes.

Results
For the unadjusted effect size comparisons, 13 of the 15 indicated that the home-use DVD outperformed group norms with an average 0.13 effect size estimate difference across the comparisons (28% improvement in the effect size for DVD condition). Comparisons of the home-use DVD condition with the mixed DVD use conditions showed no discernable pattern where one condition consistently outperformed another. Adjusted effect sizes still reinforced the superiority of the DVD conditions; however, there was some shrinkage in the effect sizes as expected with the inclusion of relevant covariates.

Conclusions
The home-use DVD shows that it is possible to effectively deliver an affordable family-based intervention using alternative technology outside of the traditional group-based class format. In almost all of the comparisons, the DVD conditions outperformed the group norms, underscoring that low-cost DVDs or viewing the videos on the Web may provide a useful surrogate for costly group-based formats. Future studies may want to improve on the quasi-experimental design by examining programmatic differences based on delivery format using a randomized controlled trial, thus strengthening the causal framework regarding program effects. In addition, the assessment protocol relied on retrospective reporting, which, although this can limit response shift bias, does not separate data collection in time as with a true pre- and posttest design.
LUTA POR MORADIA E CONTRA A PRECARIZAÇÃO DA VIDA: CONVERSA COM O MTST
Authors: Gomes entrevista Fabiana Batista Luiz Augusto De Oliveira 
Published: September 2019

A Revista Trabalho Necessário traz uma entrevista com Fabiana Batista, historiadora e militante do MTST. Fabiana atua na área de comunicação, em nível nacional, além de fazer trabalhos de base no município de Niterói e ajudar a organizar uma cozinha comunitária no município de São Gonçalo. A entrevista foi realizada em 16 de julho, em Niterói, também no estado do Rio de Janeiro
Citizen Health Science
Authors: Walls Theodore Adrien , Forkus Shannon , Coria Abbigayle 
Published: September 2019

Psychology has a long tradition of interest and experience in single subject studies, providing a forerunner scientific platform for person-level trends as they contribute to population data science. Building on this long-standing tradition, population health scientists are increasingly concerned with opportunities to draw inferences about the single case, or studies utilizing an ‘N-of-1’. At the same time, citizen scientists with health interests have become more equipped to conduct their own types of N-of-1 studies given new tools such as smart phone tracking and many other mobile health or “mHealth” devices. These advances in the single case or N-of-1 tradition sometimes involve self-tracking of health data and/or self-experimentation with one’s own health. As networks (increasingly, virtual ones) of people work to maintain or improve their health, a new platform for scientific inquiry has emerged. This paper considers how the confluence of the single case tradition and self-experimentation are key ingredients in a new data science-rich platform, that of citizen health science.
Keywords: Citizen health science, single-case designs, single-subject studies, idiographic research, self-experimentation.
MOCERA TASI RITUAL AMONG THE WOTU COMMUNITY IN EAST LUWU (The Maslahat Perspective)
Authors: Mustafa Zulhas'ari 
Published: September 2019

This article deals with the explanation of local celebration called mocera tasi performed by the ethnic Wotu community in East Luwu District. The focus of the research is closely related to the values understood by the Wotu ethnic community, in relation to the ritual of mocera tasi. Such Values, according to Community understanding, were derived from the cultural practices within the community. The ritual, in addition, was carried out by the Wotu community in order to legitimize the leadership of the Macowa Bawalipu as Wotu traditional leaders, to expressing gratitude to Allah SWT, and to rejecting reinforcements. The mocera tasi rituals as a ritual for ratifying traditional leaders are classified as adat rituals. Mocera tasi, in addition, as an expression of gratitude and refusal of reinforcements is also classified as folk ritual. The benefit to be achieved in the ritual of mocera tasi is linked to the maintenance of the benefit of Nasab (family blood) and wealth. The level of the benefit of the ritual of mocera tasi is at the level of ḥājiyyat.
THE IMPLEMENTATION OF STATE SHARIA SECURITIES BASED (SUKUK) VALUE CHAIN AT MAJENE STATE ISLAMIC COLLEGE
Authors: Thaha Fathurrahman 
Published: September 2019

This paper is mainly concernced on how to implement state sharia securities using the value chain basis at Majene State Islamic Institute. This type of research is descriptive qualitative research, using a phenomenological approach, the data sources in this study, including primary data in the form of the results of field studies conducted at this college, and secondary data in the form of documents that are considered supportive and relevant to research studies. The results of the study showed that the activities at Majene State Islamic College consisted of: (1) main activities, including: selection of prospective new students, academic activities, teaching and learning processes, initialization and promotion, research and community service. (2) supporting activities, including: the procurement of infrastructure and financing of State Sharia Securities which are supported by HR management and financial management that is illegal. The two activities have relevance, so that a value chain is formed which produces benefits in the form of security, health, comfort and convenience of State Sharia Securities buildings from State Sharia Securities , and the value of benefits, in the form of maintaining religion, soul, mind and wealth. Because the end result of this value chain is benefit, the actual activity of procuring SBSN financing facilities at Majene State Islamic Institute, researchers have the conclusion that the concept of Islamic value chain is formed.
Diagnosis and management of complications of chronic lymphocytic leukemia/small lymphocytic lymphoma
Authors: Zent Clive S. 
Published: September 2019

AbstractChronic lymphocytic leukemia (CLL) causes early-onset immune dysregulation increasing the risk of infection, second malignancies, and autoimmune complications by poorly understood mechanisms. Targeted therapy has improved therapeutic outcomes but persistent immune deficiency remains an unresolved problem. Severe infections (20/100 patient-years) cause or contribute to over 35% of CLL-related deaths. Most identified infections are bacterial (~70%) with the commonest blood isolates being Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. Viral infections (~25%) are disproportionately caused by Herpes viruses and influenza. Most common infection sites are lower respiratory tract, skin, and urogenital tract. CLL patients have an increased risk (~2-fold) of second malignancies with the commonest being squamous and basal cell skin cancer, melanoma, and lung cancer. There is a significantly increased risk of additional clonal and non-clonal non-Hodgkin lymphomas and Hodgkin lymphoma. Autoimmune cytopenias affect ~10% of CLL patients causing anemia (hemolysis and red cell aplasia), thrombocytopenia, and neutropenia. Nonhematological autoimmune complications are rare. Management of these complications requires a comprehensive multidisciplinary approach including education, preventative medicine, active monitoring, and early diagnosis and treatment. Research to better understand CLL-related immune defects and determine how to reverse them is essential for improved clinical care.
Rzadkie postacie chłoniaków T-komórkowych – aktualne postępowanie
Authors: Chmielowska Ewa 
Published: September 2019

StreszczenieChłoniaki T-komórkowe stanowią ok. 10% chłoniaków nieziarniczych. Obserwuje się zależność terytorialną występowania podtypów chłoniaków T w Europie, Stanach Zjednoczonych i Azji. Najczęstszym na świecie jest obwodowy chłoniak T (PTCL), w USA częściej niż w innych regionach występuje anaplastyczny chłoniak wielkokomórkowy (ALCL), a w Azji chłoniak z komórek NK/T typu nosowego (ENKTCL). W Europie spotykamy częściej chłoniaka angioimmunoblastycznego (AITL). Do bardzo rzadkich o specyficznym przebiegu zalicza się chłoniaka T z enteropatią (EATL), chłoniaka wątrobowośledzionowego (HSTL) czy wreszcie białaczki: z ziarnistych limfocytów, prolimfocytową, agresywną NK, ATLL. Osobną grupą są chłoniaki pierwotnie skórne: ziarniniak grzybiasty (MF) czy choroba Sezary’ego (SS). Zalecenia europejskie i polskie nie były aktualizowane od 2015 roku. Dostępne są zalecenia NCCN z 2019 roku obejmujące zmiany terapii dla chłoniaków CD30+. W zakresie leczenia ENKTCL należy korzystać także z aktualnych zaleceń azjatyckich. Choć schemat CHOP, stanowiący do niedawna terapię standardową, pozostaje jedną z opcji terapeutycznych, nie jest już ani jedyną ani zawsze rekomendowaną opcją pierwszej linii. Postępowanie jest zależne od podtypu chłoniaka, zaawansowania, a także od stanu pacjenta, jego schorzeń współistniejących. Niejasne jest miejsce autotransplantacji i allotransplantacji w leczeniu tych schorzeń, zwłaszcza jeśli rozważamy leczenie niepowodzeń, w tym kolejnych nawrotów.
Metody cytogenetyki molekularnej w różnicowaniu agresywnych B-NHL
Authors: Grygalewicz Beata 
Published: September 2019

StreszczenieB-komórkowe agresywne chłoniaki nieziarnicze (B-cell non-Hodgkin lymphoma – B-NHL) to heterogenna grupa nowotworów układu chłonnego, wywodząca się z obwodowych limfocytów B. Aberracje cytogenetyczne towarzyszące B-NHL to najczęściej translokacje onkogenów takich jak MYC, BCL2, BCL6 w okolice genowych loci dla łańcuchów ciężkich lub lekkich immunoglobulin. W niektórych przypadkach dochodzi do wystąpienia kilku wymienionych aberracji jednocześnie, tak jak w przypadkach przebiegających z równoczesną translokacją genów MYC i BCL2 (double hit), niekiedy także z obecnością rearanżacji BCL6 (triple hit). Takie chłoniaki cechuje szczególnie agresywny przebieg kliniczny. Obecnie molekularna diagnostyka cytogenetyczna przy użyciu techniki fluorescencyjnej hybrydyzacji in situ (FISH) oraz, w niektórych przypadkach, aCGH jest niezbędnym narzędziem rozpoznawania, klasyfikowania i oceny stopnia zaawansowania agresywnych, nieziarniczych chłoniaków B-komórkowych. Technika mikromacierzy CGH (aCGH) była kluczowym elementem wyróżnienia prowizorycznej grupy chłoniaków Burkitt-like z aberracją chromosomu 11q (Burkitt-like lymphoma with 11q aberration – BLL, 11q) w najnowszej klasyfikacji nowotworów układu chłonnego Światowej Organizacji Zdrowia (World Health Organization – WHO) z 2016 r. Omówione zostaną sposoby różnicowania na poziomie cytogenetycznym takich chłoniaków jak: chłoniak Burkitta (Burkitt lymphoma – BL), chłoniak rozlany z dużych komórek B (diffuse large B-cell lymphoma – DLBCL) oraz 2 nowych jednostek klasyfikacji WHO 2016, czyli chłoniaka z komórek B wysokiego stopnia złośliwości z obecnością translokacji MYC i BCL2 i/lub BCL6 (high-grade B-cell lymphoma HGBL, with MYC and BCL2 and/or BCL6 translocations) oraz chłoniaka BLL, 11q.
Chłoniak z komórek płaszcza – rola terapii celowanych
Authors: Jurczak Wojciech , Długosz-Danecka Monika 
Published: September 2019

StreszczeniePostępy w leczeniu chłoniaka z komórek płaszcza (mantle cell lymphoma – MCL) poprawiły całkowity czas przeżycia (overall survival – OS), jednak wyzwaniem pozostają postacie oporne/nawrotowe (relapsed/refractory – R/R), co warunkuje potrzebę pilnego rozwoju nowych możliwości terapeutycznych. Główne kierunki analiz to rozwój inhibitorów kinazy tyrozynowej Brutona, inhibitorów kinazy fosfatydyloinozytolu oraz inhibitorów BCL-2. Pojawiają się również obiecujące terapie obejmujące nowe przeciwciała monoklonalne oraz bispecyficzne, z zastosowaniem immunologicznych punktów końcowych oraz immunoterapii opartej na limfocytach T. Potencjalna synergia nowych metod leczenia stanowi obecnie główny nurt badań klinicznych.
Wyzwania wczesnej diagnostyki szpiczaka plazmocytowego – algorytm diagnostyczny
Authors: Giannopoulos Krzysztof , Dwilewicz-Trojaczek Jadwiga , Stompór Tomasz , Ligocki Piotr , Stopiński Marek , Sutkowski Michał , Grząśko Norbert , Morawska Marta , Kordecka Anna , Kordecki Mariusz , Jurczyszyn Artur , Dytfeld Dominik , Wróbel Tomasz , Jamroziak Krzysztof , Druzd-Sitek Agnieszka , Walter-Croneck Adam , Dmoszyńska Anna 
Published: September 2019

StreszczenieInicjatywy wczesnej diagnostyki onkologicznej podejmowane w różnych krajach mają na celu skrócenie czasu pomiędzy pojawieniem się pierwszych objawów a rozpoznaniem nowotworu. Chorzy na szpiczaka plazmocytowego mają najdłuższy, spośród wszystkich pac- jentów z najczęściej występującymi nowotworami, czas oczekiwania od zgłoszenia pierwszych objawów do rozpoznania. W efekcie prowadzi to do rozpoznawania choroby w zaawansowanym stadium i większej liczby powikłań, w tym trwałych uszkodzeń narządowych i gorszej odpowiedzi na leczenie. Powodem opóźnień diagnostycznych jest niska swoistość objawów szpiczaka. W wielu przypadkach na chorobę zapadają osoby starsze, u których choroby współistniejące mogą utrudniać rozpoznanie. Ponadto, ważną rolę odgrywa- ją bariery wczesnej diagnostyki związane z pacjentami, lekarzami i systemem opieki zdrowotnej. Aktualnie brak jest danych dotyczą- cych czasu trwania procesu diagnostycznego w Polsce. Wobec znacznego zaawansowania choroby i licznych powikłań stwierdzanych w okresie rozpoznania szpiczaka u chorych w Polsce można założyć, że istnieje duża przestrzeń do skrócenia ścieżki diagnostycznej. Pierwszym etapem jest edukacja lekarzy na temat charakterystycznych i nietypowych dla szpiczaka objawów oraz wartości testów diagnostycznych. Aby przyspieszyć ścieżkę diagnostyczną i zracjonalizować nakłady diagnostyczne przez stopniowe wykorzystywanie kolejnych zasobów w coraz mniejszych grupach osób, u których podejrzewa się zachorowanie, stworzono kalkulator diagnostyczny. Algorytm oparty o profil objawów i wyniki testów diagnostycznych polskich pacjentów może okazać się skutecznym narzędziem ułat- wiającym lekarzom rodzinnym identyfikację i kierowanie chorych na konsultację hematologiczną. Poszerzenie panelu badań gwaran- towanych o immunofiksację, wykonywaną w wyselekcjonowanej w ramach algorytmu diagnostycznego grupie osób, byłoby istotnym uzupełnieniem możliwości stawiania wstępnego rozpoznania choroby na poziomie podstawowej opieki zdrowotnej.
Autologiczna transplantacja komórek krwiotwórczych u chorych na szpiczaka plazmocytowego w dobie nowych terapii
Authors: Cioch Maria 
Published: September 2019

StreszczenieAutologiczna transplantacja komórek krwiotwórczych (AHSCT) należy do standardowych metod leczniczych u chorych na szpiczaka plazmocytowego (MM) od ponad 30 lat. Wprowadzenie do terapii nowych leków (inhibitory proteasomu, leki immunomodulacyjne, przeciwciała monoklonalne) radykalnie zmieniło główne zasady leczenia. W artykule podjęto próbę określenia miejsca AHSCT w aktualnym algorytmie terapii chorych na MM.
Postępowanie u pacjentek z nowotworem mieloproliferacyjnym BCR-ABL ujemnym w ciąży
Authors: Góra-Tybor Joanna 
Published: September 2019

StreszczenieCiąża u pacjentki z nowotworem mieloproliferacyjnym (myeloproliferative neoplasms – MPN) BCR-ABL ujemnym wiąże się z szeregiem możliwych powikłań dotyczących zarówno matki, jak i płodu, takich jak: częstsze powikłania zakrzepowe i krwotoczne u matki, zwiększone ryzyko poronień, częstsze dysfunkcje łożyska i związane z nimi: opóźnienie wzrostu płodu, porody przedwczesne, późne utraty płodu. Opieka nad ciężarną z MPN wymaga ścisłej współpracy specjalistów hematologa i ginekologa oraz wdrożenia postępowania zgodnego z obowiązującymi standardami (właściwej profilaktyki przeciwzakrzepowej i ewentualnego leczenia cytoredukcyjnego). W artykule omówiono aktualne zalecenia dotyczące monitorowania i terapii w trakcie ciąży i okresie połogu u kobiety z MPN.
The prognostic value of mean platelet volume in cancer patients
Authors: Masternak Marta , Knap Joanna , Giannopoulos Krzysztof 
Published: September 2019

AbstractBasic hematological indices, such as platelets count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT), are readily accessible and commonly tested indicators. As platelets play a significant role in many physiological and patho- logical pathways, the abnormalities in these indices inference about irregularities within the organism, such as homeostatic disorders or inflammation. Recent studies revealed a significant impact of MPV on the course and prediction in different types of neoplasms. This review summarizes the most important studies on the impact of MPV levels on outcome and prognosis in different types of cancer conducted in recent years. MPV levels have a significant impact on the length of progression-free survival (PFS) and overall survival (OS) in many types of solid tumors, such as colorectal carcinoma, gastric cancer, pancreatic cancer, esophageal cancer, non-small cell lung cancer, breast cancer, and thyroid cancer. They also affect the prognosis in some lymphoproliferative diseases, such as diffuse large B-cell lymphoma, acute lymphoblastic leukemia, or primary and secondary myelofibrosis.
Infectious complications in children and adults with hematological malignancies
Authors: Styczyński Jan 
Published: September 2019

AbstractInfections are the main cause of morbidity and mortality in pediatric hematology and oncology (PHO) and hematopoietic cell transplantation (HCT) settings in children and adults. The analysis of incidence and outcome of bacterial, fungal, and viral infections in Polish PHO/ HCT centers was performed over a period of 72 months (2012–2017). The summary of infections in 5628 patients with newly diagnosed malignancy and 971 HCTs is presented in this paper. Additionally, data of 650 pediatric HCTs from 2012 to 2015 were compared with the data of 3200 HCTs in adults. The risk of any infection per patient was higher in HCT vs PHO patients (2062/971 vs 7115/5628; 2.1 vs 1.3; HR=1.7, p<0.0001). The incidence of bacterial infections was 34,2±0,6% in PHO vs 41,5±1,6% in HCT patients, and the outcome was better in PHO patients: 97,9±0,2% vs 91,8±1,0%. The incidence of patients with fungal infection was 8,8±0,4% vs 21,2±1,3%, and the outcome was better in PHO patients: 95,9±0,7% vs 85,8±2,3%. Incidence of viral infections was 5,0±1,0% in PHO setting, including part of previously transplanted patients, and 47,8±2,2% in HCT setting (60,9±2,3% allo-HCT; 5,6±1,3% auto-HCT). In children, the incidence was higher for bacterial (36.0% vs 27.6%), fungal (25.3% vs 6.3%), and viral (56.3% vs 29.3% allo-HCT; 6.6% vs 0.8% auto-HCT) infections than in adults (p<0.0001), and the outcome was better for bacterial (95.5% vs 91.4%), fungal (88.0% vs 74.9%), and viral (98.6% vs 92.3%) infections. In conclusion, the presented large studies have determined the incidence of infectious complications and their outcomes in HCT and PHO centers in Poland.