bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does integration of Magee equations into routine clinical practice affect whether oncologists order the Oncotype DX test? A prospective randomized trial
Authors: Robertson Susan J. , Ibrahim Mohammed F.K. , Stober Carol , Hilton John , Kos Zuzana , Mazzarello Sasha , Ramsay Tim , Fergusson Dean , Vandermeer Lisa , Mallick Ranjeeta , Arnaout Angel , Dent Susan F. , Segal Roanne , Sehdev Sandeep , Gertler Stan , Hutton Brian , Clemons Mark 
Published: January 2019

AbstractObjectiveThe three Magee Equations provide an estimate of the Oncotype DX recurrence score using commonly available clinicopathologic information (tumour size, grade, oestrogen receptor, progesterone receptor, HER2, and Ki67). We assessed whether integration of Magee Equations into routine clinical practice affected the frequency of Oncotype DX requests.MethodsPatients with newly diagnosed, node negative, hormone receptor positive, and HER2 negative invasive breast cancer were randomized to undergo a Magee calculation or not. At the first clinic assessment, the oncologist was provided with all routinely available clinicopathologic information (including Ki67) either with or without the results of Magee Equations. Primary outcome was frequency of Oncotype DX ordering. Secondary outcomes included frequency of chemotherapy use, time to commencement of radiotherapy, or systemic therapy. Physician comfort with systemic therapy choices and the use of Ki67 and Magee Equations was also assessed.ResultsData from 175 randomized patients was available, 84 patients (48%) with and 91 (52%) without calculated Magee Equations. Oncotype DX was ordered in 10 (12.05%) and 13 (14.44%) (RR 0.83, 0.39‐1.80; P = 0.64) in the Magee and no Magee groups, respectively. There were no statistically or clinically significant differences between the randomized groups for any of the secondary outcomes. Availability of both Ki67 and Magee Equations was associated with increased physician comfort around systemic treatment decisions.ConclusionsIn a practice where Ki67 is routinely available, addition of Magee Equations into routine clinic practice was not associated with a reduction in Oncotype DX use. Availability of both Ki67 and Magee Equations did however increase physician comfort with systemic therapy decisions.
Association of low skeletal muscle mass with advanced liver fibrosis in patients with non‐alcoholic fatty liver disease
Authors: Kang Min Kyu , Park Jung Gil , Lee Heon Ju , Kim Min Cheol 
Published: January 2019

AbstractBackground and AimAlthough low skeletal muscle mass (LSMM) is known to increase the risk of non‐alcoholic fatty liver disease (NAFLD), limited reports have described the relationship between LSMM and advanced fibrosis. Here, we investigated the association between LSMM and advanced liver fibrosis in NAFLD patients.MethodsFatty liver was diagnosed using ultrasound, and appendicular skeletal muscle mass (ASM) was measured using bioelectrical impedance analysis. LSMM was defined in two ways: ASM/body weight percentage (LSMM‐BW) and ASM/body mass index. Liver fibrosis stage was assessed by two models, the NAFLD fibrosis score and the Fibrosis‐4 index, which determined low and high cutoff values (COVs).ResultsOf 10 711 NAFLD patients, 615 were diagnosed with LSMM‐BW. LSMM patients were older (47.6 vs 52.5 years, P = 0.001) and had higher body mass index values (23.6 vs 29.1 kg/m2, P < 0.001) and waist circumferences (80.1 vs 93.3 cm, P < 0.001) than non‐LSMM patients. LSMM was an independent risk factor for advanced fibrosis assessed by a low COV for the Fibrosis‐4 index regardless of its classification (adjusted for metabolic and lipid profiles and sex, odds ratio [OR], 1.27–2.01; all P < 0.05). LSMM was an independent risk factor for advanced fibrosis assessed by both COVs of NAFLD fibrosis score (adjusted for obesity, hypertension, lipid profile, and sex; OR, 1.64–2.01, P < 0.01 in the low COV group; OR, 2.68–3.12, P = 0.002 in the high COV group).ConclusionsLow skeletal muscle mass is associated with advanced fibrosis in NAFLD patients independent of metabolic risk factors.
Intention to leave among staff nurses in small‐ and medium‐sized hospitals
Authors: Park Jeong Hye , Park Min Jung , Hwang Hye Young 
Published: January 2019

AbstractAims and objectivesTo explore the factors associated with the intention to leave among nurses in small‐ and medium‐sized hospitals and to determine the predictors about work environment and rewards.BackgroundCompared with large hospitals, insight into the working conditions, rewards and turnover of nurses working for these hospitals is lacking internationally.DesignCross‐sectional study design.MethodsData were obtained from the Korean Nurses Association's 2016 Welfare Policy and System Improvement Survey. Of the participants, data from 951 staff nurses working three shifts were analysed using hierarchical multiple regression to explore the predictors of nurses’ turnover intention. This study complied with the Strengthening the Reporting of Observational studies in Epidemiology.ResultsThe perceived pay level satisfaction was the most obvious and persistent predictor of the intention to leave. Living benefits were shown to be scarcely satisfied, rendering considerable influence on turnover intention. Concerning aspects related to the working environment, the implementation of contract‐abiding working hours and nurse‐friendly night shift schedules reduced the turnover intention of nurses.ConclusionsNurses in small‐ and medium‐sized hospitals are likely to have particular challenges in terms of professional growth. When fundamental rewards and basic working conditions are acceptable to nurses, their turnover can be reduced, and the professional growth can also be expected. Hospitals with a high nurse turnover rate need to preferentially verify these factors perceived by their nurses and to improve to increase nurses’ retention.Relevance to clinical practiceUnderstanding the determinants of intention to leave can lead to the development of strategies that persuade nurses to remain employed. These findings inform policymakers, nurse managers and hospital managers of the causes of nurses’ intentions to leave in small‐ and medium‐sized hospitals. Our findings also provide empirical data on the working conditions and rewards of these nurses and suggest strategies for their retention.
Identifying selection criteria for non‐radical hysterectomy in FIGO stage IB cervical cancer
Authors: Kasamatsu Takahiro , Ishikawa Mitsuya , Murakami Naoya , Okada Satoshi , Ikeda Shun‐Ichi , Kato Tomoyasu , Itami Jun 
Published: January 2019

AbstractAimThis retrospective study sought to identify the selection criteria required for a non‐radical hysterectomy with minimal parametrectomy in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB invasive cervical cancer.MethodsOverall, 461 patients with FIGO stage IB cervical cancer who underwent a radical hysterectomy were reviewed clinicopathologically according to pathological tumor size (≤2 cm, >2 – ≤4 cm, and > 4 cm).ResultsThe pathological parametrial involvement rate in the less than equal to 2 cm group (2%) was significantly lower than in greater than 2–less than equal to 4 cm (13%) or greater than 4 cm (29%) groups (both P < 0.001). The 5‐year overall survival rate was significantly higher in the less than equal to 2 cm group (97%, 95% confidence interval [CI] 94–99%) compared with greater than 2–less than equal to 4 cm (90%, 95% CI 94–86%) and greater than 4 cm (70%, 95% CI 79–60%) groups (both P < 0.001). Cox model analysis identified tumor size to be an independent prognostic factor for survival (95% CI 1.33–5.78) and recurrence (95% CI 1.31–5.66) compared to other pathological factors. However, a significant difference between the three groups was not found in rates of Grade 3 or 4 adverse events following radical hysterectomy (P = 0.19).ConclusionsTumor size is an independent prognostic factor for survival in patients with FIGO stage IB invasive cervical cancer. This retrospective study suggests that FIGO stage IB patients with a less than equal to 2 cm tumor size are optimal candidates for non‐radical hysterectomy with minimal parametrectomy, and without resulting bladder dysfunction.
Japan Obstetric Compensation System for Cerebral Palsy: Strategic system of data aggregation, investigation, amelioration and no‐fault compensation
Authors: Ushiro Shin , Suzuki Hideaki , Ueda Shigeru 
Published: January 2019

AbstractThe Japan Obstetric Compensation System for Cerebral Palsy (JOCS‐CP), which investigates, develops preventive mechanisms and awards monetary compensation, to cases of cerebral palsy was urgently introduced in 2009 in response to growing concern about Japan's deteriorating perinatal care and low birthrate. Under the political leadership, the Japan Council for Quality Health Care launched the JOCS‐CP with support of various stakeholders. The JOCS‐CP features of no‐fault‐based compensation which was discussed decades ago in the Japan Medical Association aiming at financial aid to patient and family and early settlement of dispute. As of 2017, 2233 petitions had been approved by the Review Committee for compensation. All the approved cases were consecutively put on analysis in the Investigation Committee which has compiled more than 1000 Investigative Reports. The reports were delivered not only to the childbirth facility but to the guardians/families. Survey revealed that most of childbirth facility and the guardians/families responded in favor of the reports. With regard to amelioration of profound cerebral palsy, the Prevention Report has been published on annual basis through analysis of all the Investigative Reports. The Prevention Reports and other educational materials were produced and distributed not only among medical professionals but among pregnant women. It is notable that the number of lawsuit filing related to obstetrics demonstrated rapid decrease compared to that of other medical specialties. The JOCS‐CP could be described as a social experiment. It was overhauled in 2015 but deserves further discussion on reform for evolving into better system.
Water column dissolved silica concentration limits microphytobenthic primary production in intertidal sediments
Authors: Bohórquez Julio , Calenti Danielle , García‐Robledo Emilio , Papaspyrou Sokratis , Jimenez‐Arias Juan Luis , Gómez‐Ramírez Eddy Humberto , Corzo Alfonso 
Published: January 2019

Primary production of microphytobenthos (MPB) contributes significantly to the total production in shallow coastal environments. MPB is a diverse community in which diatoms are usually the main microalgal group. Diatoms require N, P, and other nutrients as with other autotrophs, but in addition require silicate to create their outer cell wall. Therefore, dissolved silica (DSi) might be a potential limiting factor for benthic primary production in areas with reduced freshwater input. To test this hypothesis, a microcosm experiment was conducted using intact sediment cores collected from an intertidal mudflat in the Bay of Cádiz and supplied with increasing concentrations of DSi (0, 5, 10, 25, and 45 μmol · L−1). After 7 d of enrichment, we determined chlorophyll a and c (Chl a, c) contents, metabolic rates (Net [Pn] and Areal Gross [PgA] Production and Light [RL] and Dark [RD] Respiration), as well as fluxes of inorganic nutrients across the sediment‐water interface. Chl a and c contents increased significantly with respect to the initial conditions but no differences between treatments were found. Both Pn and PgA showed a saturating‐like pattern with silicate concentration, reaching maximum rates at a DSi concentration of 45 μmol · L−1. The addition of DSi also resulted in an increase of DSi and ammonium uptake by the sediment, which was significantly higher in light than in darkness. Our results clearly show that water column DSi concentrations have a direct impact on benthic primary production, also controlling other related processes such as inorganic nutrient fluxes.
Dynamics of alveolar bone healing after the removal of orthodontic temporary anchorage devices
Authors: Kim Sung‐Jin , Ha Young Don , Kim Eunji , Jang Woowon , Hwang Soonshin , Nguyen Tung , Ko Ching‐Chang , Choi Yoon Jeong , Kim Kyung‐Ho , Chung Chooryung J. 
Published: January 2019

ObjectiveThe aim of this study was to investigate the dynamics of alveolar bone formation and healing pattern after the removal of orthodontic temporary anchorage devices (TADs).MethodsMiniscrews (N = 32) were inserted into the buccal inter‐radicular alveolar bone in beagle dogs. Afterward, miniscrews were removed at different time points during a 13‐week period and six different in vivo fluorescent markers were injected at 1, 2, 6, 8, 10, and 12 weeks. Serial changes in bone apposition at the removal and intact control sites were evaluated using μCT, histology, and bone histomorphometry.ResultsGradual bone apposition at the TAD removal site was noted with bone volume/tissue volume (BV/TV) reaching the level of the control alveolar bone by 7 weeks. Histologically, newly formed woven bone was detected within the removal site which was distinct from the surrounding pre‐existing alveolar bone at 13 weeks. Accelerated mineral apposition rate (MAR) and bone formation rate (BFR) were noted between 2 and 6 weeks in the removal site (P < 0.05). Although MAR and BFR gradually decreased after its peak at 2‐4 weeks, BFR in the removal site was still higher than the control site at 10‐12 weeks (P < 0.05).ConclusionsSpontaneous bone healing was noted after TAD removal with regional acceleration of MAR and BFR within 2‐6 weeks. However, the removal site was mainly filled with woven bone even after 13 weeks, suggesting a longer healing period is required for the quality of the alveolar bone to reach levels comparable to the surrounding alveolar bone.
The Development of Implicit and Explicit Knowledge of Collocations: A Conceptual Replication and Extension of Sonbul and Schmitt (2013)
Authors: Toomer Mark , Elgort Irina 
Published: January 2019

Sonbul and Schmitt (2013) showed that exposure to second language (L2) collocations in reading texts can produce gains in explicit knowledge, but they found no evidence of gains in implicit knowledge. This study is a conceptual replication and extension of Sonbul and Schmitt's research. Sixty‐two advanced English as a second language (ESL) speakers read texts containing repeated occurrences of low‐frequency medical collocations in three sessions over 2 days. The incidental learning treatments included reading only (no typographic enhancement), bolding, and bolding‐plus‐glossing. Collocational knowledge was assessed in tests of explicit knowledge (cued recall, form recognition) and a test of implicit knowledge (primed lexical decision). Repeated exposure to bolded collocations produced greater explicit knowledge than repeated exposure to typographically unenhanced collocations. Evidence of implicit knowledge development was observed in the unenhanced (reading only) treatment but not in the remaining treatments. These results replicated Sonbul and Schmitt's findings for explicit knowledge and extended their findings for implicit knowledge.Open PracticesThis article has been awarded an Open Materials badge. All materials are publicly accessible via the Open Science Framework at https://osf.io/qy2c3. Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki.
Protestant Techniques of Care: The Hindu, the Pentecost, and the “Secular”
Authors: Whitmarsh Ian 
Published: January 2019

AbstractModern techniques of caring for the self through staying healthy rely on an ethic of choice, often evoking critiques of the (neo)liberal subject. This sense of choice has carried frequently overlooked Protestant commitments from Luther to Kant and Locke to 19th‐century American health reformers, premised on a refusal of ritual, mysticism, and the priest as the source of truth. This article explores how these implicit commitments shape the relation to other religious traditions in countries like Trinidad. Campaigns against chronic disease in Trinidad carried out in public health venues and churches echo multinational health projects in pronouncing, “We all want a healthy life.” The article draws on a Caribbean ironic sense of secularity to analyze the way that the threat to this “want” found in other religious traditions such as Pentecostal healing and Hindu ecstatic practices reveals Protestant commitments masked within a modern global “secular” care of the self.
Population trends for humpback whales (Megaptera novaeangliae) foraging in the Francisco Coloane Coastal‐Marine Protected Area, Magellan Strait, Chile
Authors: Monnahan Cole C. , Acevedo Jorge , Noble Hendrix A. , Gende Scott , Aguayo‐Lobo Anelio , Martinez Francisco 
Published: January 2019

AbstractIn 2003 a feeding aggregation of southeastern Pacific humpback whales (Megaptera novaeangliae) was reported in the Magellan Strait. While Chile established its first marine national park in the Strait to protect humpback whale habitat, fatal ship strikes remain a concern because of overlap with a busy shipping lane. To better understand population risk, we estimated abundance and survival for this population using Bayesian robust‐design mark‐recapture models fit to photographic data from 2004 to 2016. Overall, the model estimated a total of 204 whales (95% CI: 199–210) during the last 12 yr, and 93 (95% CI: 86–100) in the 2016/2017 austral summer. The population grew at 2.3% (CI: 2.1%–3.1%), an annual increase of two whales. Annual survival (including calves) was estimated at 0.892 (CI: 0.871–0.910). Our results corroborate a persistent feeding population, but one that is increasing relatively slowly. Owing to its vulnerability stemming from its small size, coupled with significant overlap with a busy shipping lane, we argue this subpopulation is at significant risk from ship strikes and may be one of the few populations where anthropogenic mortalities could regulate population dynamics. We therefore encourage continued monitoring via photographic mark‐resighting surveys, and analyses explicitly investigating potential population‐level ship strike effects.
24‐hour monitoring of transient lower esophageal sphincter relaxation events by long‐term high‐resolution impedance manometry in normal volunteers: The “mirror phenomenon”
Authors: He Suyu , Jell Alissa , Hüser Norbert , Kohn Nils , Feussner Hubertus 
Published: January 2019

AbstractBackgroundThe aim of this study was to investigate the frequency and circadian changes in transient lower esophageal sphincter relaxations (TLESRs) in normal volunteers using 24‐hour high‐resolution impedance manometry (HRIM).MethodsFifteen volunteers underwent HRIM. TLESRs were recorded during the mealtime, 2‐hour postprandial, daytime, and supine periods. The catheter was firmly secured to the nose, and subjects went home, ate normal meals, and continued routine daily activities.Key ResultsSuccessful recordings were obtained in 11 volunteers. Overall, 1083 TLESRs were documented; the average occurrence was 4.2/h, and the duration was 21.0 ± 5.2 seconds. The majority of the TLESRs occurred during the 2‐hour postprandial (42.7%) and daytime (31.5%) periods, while 10.2% and 15.6% occurred during the mealtime and supine periods, respectively. Eight hundred and eighty‐six (81.8%) TLESRs were associated with reflux. Overall, 25.5% of TLESRs were preceded by partial secondary peristalsis (PSP), while 74.5% were preceded by nothing. Terminating events included primary peristalsis (PP; 40.3%), PSP (42.8%), full secondary peristalsis (FSP; 8.2%), or nothing (8.7%). Both preceding and terminating events periodically changed throughout the four periods. One hundred and twelve (10.3%) TLESRs with both preceding and terminating events of PSP, presenting as a “mirror phenomenon,” were documented. The majority of these TLESRs occurred during the supine (70.5%).Conclusions & InferencesTransient lower esophageal sphincter relaxations are common physiological motor events in normal volunteers; these events have certain circadian rhythms, as do the events that precede and terminate TLESR events. A special “mirror phenomenon” is observed when both the preceding and terminating events are PSP.
Electroacupuncture promotes the gastrointestinal motility of diabetic mice by CNP/NPR‐B‐cGMP and PDE3A‐cGMP signaling
Authors: An Jing , Li YingLi , Song ShuangNing , Liu Shi 
Published: January 2019

AbstractBackgroundElectroacupuncture (EA) can promote gastrointestinal (GI) motility of diabetic mice, but the mechanism is not clearly elucidated. Natriuretic peptides (NPs) were related to the diabetes‐induced gut dysfunction of mice, which may be associated with ICC (interstitial cells of cajal). Besides, EA could increase the ICC of diabetic mice. Our aim was to explore whether EA can promote the gut motility by CNP/NPR‐B‐cGMP and PDE3A‐cGMP signaling in diabetic mice, and the relationship between NPs and ICC.MethodsWild C57BL/6 male mice were divided into five groups: control group, diabetic mellitus (DM group), diabetic mellitus plus sham EA group (SEA), diabetic mellitus plus low‐frequency EA group (LEA), and diabetic mellitus plus high‐frequency group (HEA). Gastrointestinal motility was assessed by gastric emptying and GI transit test. Immunofluorescence staining was applied to assess the expression level of CNP, NPR‐B, and c‐Kit. Western blot, PCR, and ELISA were used to detect the level of CNP, NPR‐B, PDE2A, PDE3A, c‐Kit, mSCF, and cGMP content. The correlativity between NPR‐B and mSCF was evaluated by Pearson's correlation and linear regression analyses.Key Results(a) EA could improve the GI dysfunction of diabetic mice. (b) CNP, NPR‐B, and cGMP contents were decreased, but the level of PDE3A, c‐Kit, and mSCF was increased in the EA groups. (c) There was a negative correlation between NPR‐B and mSCF among the groups.Conclusions and InferencesElectroacupuncture promotes the GI function by CNP/NPR‐B‐cGMP and PDE3A‐cGMP signaling in diabetic mice; up‐regulated mSCF/c‐Kit signaling by EA may be mediated partially via down‐regulation of CNP/NPR‐B signaling.
No Reasons to Believe the False
Authors: de Prado Javier González 
Published: January 2019

AbstractI argue that if there are nondisabled reasons to believep, then there cannot be nondisabled reasons to believe something incompatible withp. I first defend a restricted version of the view, which applies only to situations where the relevant agent has complete evidence. Then, I argue for a generalized version of the view, which holds regardless of the agent's evidence. As a related result, I show that, given plausible assumptions, there cannot be nondisabled reasons to believe something false.