bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Assessment of Lifetime Solar Ultraviolet Radiation Exposure in Epidemiologic Studies: Comparison of Ultraviolet Exposure Assessment Methods in a Nationwide U.S. Occupational Cohort
Authors: Little Mark P. , Tatalovich Zaria , Linet Martha S. , Fang Michelle , Kendall Gerald M. , Kimlin Michael G. 
Published: June 2018

AbstractSolar ultraviolet radiation is the primary risk factor for skin cancers and sun‐related eye disorders. Estimates of individual ambient ultraviolet irradiance derived from ground‐based solar measurements and from satellite measurements have rarely been compared. Using self‐reported residential history from 67 189 persons in a nationwide occupational US radiologic technologists’ cohort, we estimated ambient solar irradiance using data from ground‐based meters and noontime satellite measurements. The mean distance moved from city of longest residence in childhood increased from 137.6 km at ages 13–19 to 870.3 km at ages ≥65, with corresponding increases in absolute latitude difference moved. At ages 20/40/60/80, the Pearson/Spearman correlation coefficients of ground‐based and satellite‐derived potential solar ultraviolet exposure, using irradiance and cumulative radiant exposure metrics, were high (=0.87–0.92). There was also moderate correlation (Pearson/Spearman correlation coefficients = 0.51–0.60) between irradiance at birth and at last‐known address, for ground‐based and satellite data. Satellite‐based lifetime estimates of ultraviolet radiation were generally 14–15% lower than ground‐based estimates, albeit with substantial uncertainties, possibly because ground‐based estimates incorporate fluctuations in cloud and ozone, which are incompletely incorporated in the single noontime satellite‐overpass ultraviolet value. If confirmed elsewhere, the findings suggest that ground‐based estimates may improve exposure assessment accuracy and potentially provide new insights into ultraviolet radiation–disease relationships in epidemiologic studies.
Mycobacterium abscessus Left Ventricle Assist Device Driveline Infections: An Emerging Pathogen?
Authors: Nunez Breton Jonatan David , Hernandez Gabriel , Simkins Jacques , Chaparro Sandra Viviana 
Published: June 2018

AbstractThe use of left ventricular assist device is associated with improvement in survival in patients with refractory heart failure. However, driveline infection limits the success of its use as it is associated with significant mortality. We describe the first 2 cases of Mycobacterium abscessus driveline infection. Both patients had persistent infection despite of aggressive antibiotic treatment and local debridement, and only improved after removal of their left ventricular assist devices.
Treatment of carprofen overdose with therapeutic plasma exchange in a dog
Authors: Kjaergaard Astrid B. , Davis Jennifer L. , Acierno Mark J. 
Published: June 2018

AbstractObjectiveTo report the use of therapeutic plasma exchange (TPE) in a dog with carprofen toxicosis.SummaryA 6‐year‐old female neutered Bichon Frise weighing 6.9 kg was examined after it had ingested 72 mg/kg carprofen. Mild dehydration without azotemia and with a urine specific gravity of 1.050 was noted at presentation. Treatment consisted of induction of emesis, symptomatic medical therapy, and TPE. The TPE achieved 1.5 plasma volume exchanges over 3 hours. Blood samples and effluent samples were collected every 30 minutes during TPE and additional blood samples were collected 11 and 35 hours after treatment. Carprofen concentrations in these samples were determined by high‐pressure liquid chromatography. A 51% reduction in serum carprofen concentration was achieved following TPE.New or Unique Information ProvidedThis report describes the successful reduction of plasma carprofen concentration in a dog using TPE. Although recent studies suggest that this particular dog may not have received a toxic dose, a 51% reduction of plasma carprofen concentration was achieved over 180 minutes, and TPE may be beneficial for treatment of dogs that have ingested higher doses.
Treatment of acute kidney injury secondary to oak intoxication with hemodialysis in a miniature zebu
Authors: Davy‐Moyle Rachel B. , Londoño Leo , Nelson Elizabeth A. , Bandt Carsten 
Published: June 2018

AbstractObjectiveTo describe the successful management of acute kidney injury (AKI) secondary to oak intoxication using hemodialysis in a miniature zebu.Case SummaryA 1‐year‐old male intact miniature zebu was presented for evaluation of a 2‐day history of lethargy, anorexia, decreased urine production, and dry, firm stool. Initial diagnostics revealed severe azotemia and the bull was presumptively diagnosed with AKI secondary to oak intoxication due to free access to oak trees in the pasture. Despite conventional management with IV fluids and supportive therapy, the degree of azotemia progressively worsened, and the bull became oliguric and fluid overloaded. Two treatments with hemodialysis resulted in reduction of azotemia and ketonemia, and resolution of fluid overload and oliguria. The zebu was discharged from the hospital after 10 days of hospitalization.New or Unique Information ProvidedTo the authors’ knowledge, this is the first reported case using hemodialysis for AKI in a bovid. Treatment with hemodialysis was effective in this case resulting in rapid resolution of azotemia, fluid overload, and oliguria. Hemodialysis may hasten the recovery and decrease morbidity and mortality in bovids with AKI.
Canine ovariectomy by hybrid or total natural orifice transluminal endoscopic surgery: technical feasibility study and pain assessment
Authors: Linhares Marcella Teixeira , Feranti João Pedro Scussel , Coradini Gabriela Pesamosca , Martins Letícia Reginato , Martins Arthur Rodrigues , Sarturi Vanessa Zanchi , Gavioli Felipe Baldissarella , Machado Silva Marco Augusto , de Ataíde Michelli Westphal , Teixeira Luciana Gonçalves , Brun Maurício Veloso 
Published: June 2018

AbstractObjectiveTo compare technical feasibility, surgical time, surgical complications, and postoperative pain in ovariectomy (OVE) by hybrid and total natural orifice transluminal endoscopic surgery (NOTES).Study designProspective randomized clinical trial.AnimalsSixteen healthy and sexually intact bitches.MethodsDogs were randomly assigned to the hybrid NOTES group (HNG; n = 8) and the total NOTES group (TNG; n = 8) to compare surgical time, pain scores and complications. Pain was assessed by using the visual analog scale (VAS) and the Melbourne pain scale (MPS).ResultsSurgical time did not differ between the experimental groups (HNG = 46.3 ± 18.5 minutes, TNG = 54.6 ± 31.1 minutes). Exteriorization of the ovaries through the vaginal wound was the major difficulty. Complications were minor in both groups and occurred intraoperatively only in the HNG, and in both groups post operatively. No dogs required rescue analgesia in the intraoperative or postoperative period. There were no differences in VAS or MPS scores between the groups for any surgical times except for the VAS assessment at 72 hours after extubation (HNG = 1.1 ± 0.3, TNG = 0.7 ± 0.4,P = .0221).ConclusionBoth NOTES techniques were comparable for canine OVE, with no requirement for additional analgesia in the postoperative periods. It was not possible to determine whether there was a clear advantage of one technique rather than the other.Clinical significanceThe minimally invasive techniques proposed for laparoscopic OVE are feasible for dogs with low pain scores and low rates of complications for both groups.
Coaching and Coach Education in the Football Association of Ireland
Authors: O’Regan Niall , Kelly Seamus 
Published: June 2018

The island of Ireland is quite unique in its dynamic due, in part, to the geographical and political separation between Northern Ireland and the Republic of Ireland. Historically, the Island of Ireland had one governing body for association football. Currently, the Irish Football Association (IFA) governs Northern Ireland while the Football Association of Ireland (FAI) governs the Republic of Ireland in the south. Interestingly, not all sports (e.g., Irish Rugby Football Union) on the Island of Ireland have separate Governing Bodies. This paper provides a brief historical overview of this separation between the FAI and IFA. Following this, we explore the history of coach education in the FAI and an overview of the FAI Player Development Plan. Then, we explore how coach education was, and is currently, structured with particular focus on recent improvements in terms of how coach education courses are delivered and assessed. The final section provides a brief overview of the future of coach education within the FAI.
Antibacterial Activity of Human Simulated Epithelial Lining Fluid Concentrations of Ceftazidime-Avibactam Alone or in Combination with Amikacin Inhale (BAY41-6551) against Carbapenem-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae
Authors: Almarzoky Abuhussain Safa S. , Kuti Joseph L. , Nicolau David P. 
Published: June 2018

ABSTRACT

The role of inhalational combination therapy when treating carbapenem-resistant
Pseudomonas aeruginosa
and
Klebsiella pneumoniae
with newer beta-lactam/beta-lactamase inhibitors has not been established. Using a 72-h
in vitro
pharmacodynamic chemostat model, we simulated the human exposures achieved in epithelial lining fluid (ELF) following intravenous treatment with ceftazidime-avibactam (CZA) 2.5 g every 8 h (q8h) alone and in combination with inhaled amikacin (AMK-I) 400 mg q12h, a reformulated aminoglycoside designed for inhalational administration, against three
P. aeruginosa
isolates (CZA [ceftazidime/avibactam] MICs, 4/4 to 8/4 μg/ml; AMK-I MICs, 8 to 64 μg/ml) and three
K. pneumoniae
isolates (CZA MICs, 1/4 to 8/4 μg/ml; AMK-I MICs, 32 to 64 μg/ml). Combination therapy resulted in a significant reduction in 72-h CFU compared with that of CZA monotherapy against two of three
P. aeruginosa
isolates (−4.14 log
10
CFU/ml,
P
= 0.027; −1.42 log
10
CFU/ml,
P
= 0.020; and −0.4 log
10
CFU/ml,
P
= 0.298) and two of three
K. pneumoniae
isolates (0.04 log
10
CFU/ml,
P
= 0.963; −4.34 log
10
CFU/ml,
P
< 0.001; and −2.34 log
10
CFU/ml,
P
= 0.021). When measured by the area under the bacterial growth curve (AUBC) over 72 h, significant reductions were observed in favor of the combination regimen against all six isolates tested. AMK-I combination therapy successfully suppressed CZA resistance development in one
K. pneumoniae
isolate harboring
bla
KPC-3
that was observed during CZA monotherapy. These studies suggest a beneficial role for combination therapy with intravenous CZA and inhaled AMK when treating pneumonia caused by carbapenem-resistant Gram-negative bacteria.
Assessment of the
In Vivo
Activity of SPR741 in Combination with Azithromycin against Multidrug-Resistant Enterobacteriaceae Isolates in the Neutropenic Murine Thigh Infection Model
Authors: Stainton Sean M. , Abdelraouf Kamilia , Utley Luke , Pucci Michael J. , Lister Troy , Nicolau David P. 
Published: June 2018

ABSTRACT

SPR741 is a novel agent with structural similarity to polymyxins that is capable of potentiating the activities of various classes of antibiotics. Previously published studies indicated that although
Enterobacteriaceae
isolates had minimal susceptibilities to azithromycin (AZM), the
in vitro
antimicrobial activity of AZM against
Enterobacteriaceae
was enhanced when it was combined with SPR741. The current study evaluated the
in vivo
activity of human-simulated regimens (HSR) of AZM equivalent to clinical doses of 500 mg given intravenously (i.v.) every 24 h (q24h) and SPR741 equivalent to clinical doses of 400 mg q8h i.v. (1-h infusion), alone and in combination, against multidrug-resistant (MDR)
Enterobacteriaceae
. We studied 30 MDR
Enterobacteriaceae
isolates expressing a wide spectrum of β-lactamases (ESBL, NDM, VIM, and KPC), including a subset of isolates positive for genes conferring macrolide resistance (
mphA
,
mphE
,
ermB
, and
msr
).
In vivo
activity was assessed as the change in log
10
CFU per thigh at 24 h compared with 0 h. Treatment with AZM alone was associated with net growth of 2.60 ± 0.83 log
10
CFU/thigh. Among isolates with AZM MICs of ≤16 mg/liter, treatment with AZM-SPR741was associated with an average reduction in bacterial burden of −0.53 ± 0.82 log
10
CFU/thigh, and stasis to 1-log kill was observed in 9/11 isolates (81.8%). Combination therapy with an AZM-SPR741 HSR showed promising
in vivo
activity against MDR
Enterobacteriaceae
isolates with AZM MICs of ≤16 mg/liter, including those producing a variety of β-lactamases. These data support a potential role for AZM-SPR741 in the treatment of infections due to MDR
Enterobacteriaceae
.
Health inequalities in hospitalisation and mortality in patients diagnosed with heart failure in a universal healthcare coverage system
Authors: Garcia Raquel , Abellana Rosa , Real Jordi , del Val José-Luis , Verdú-Rotellar Jose Maria , Muñoz Miguel-Angel 
Published: June 2018

BackgroundInformation regarding the effect of social determinants of health on heart failure (HF) community-dwelling patients is scarce. We aimed to analyse the presence of socioeconomic inequalities, and their impact on hospitalisations and mortality, in patients with HF attended in a universal healthcare coverage system.MethodsA retrospective cohort study carried out in patients with HF aged >40 and attended at the 53 primary healthcare centres of the Institut Català de la Salut in Barcelona (Spain). Socioeconomic status (SES) was determined by an aggregated deprivation index (MEDEA). Cox proportional hazard models and competing-risks regression based on Fine and Gray’s proportional subhazards were performed to analyse hospitalisations due to of HF and total mortality that occurred between 1 January 2009 and 31 December 2012.ResultsMean age was 78.1 years (SD 10.2) and 56% were women. Among the 8235 patients included, 19.4% died during the 4 years of follow-up and 27.1% were hospitalised due to HF. A gradient in the risk of hospitalisation was observed according to SES with the highest risk in the lowest socioeconomic group (sHR 1.46, 95% CI 1.27 to 1.68). Nevertheless, overall mortality did not differ among the socioeconomic groups.ConclusionsIn spite of finding a gradient that linked socioeconomic deprivation to an increased risk of hospitalisation, there were no differences in mortality regarding SES in a universal healthcare coverage system.
Dehydrated citrus pulp in broiler diets
Authors: Diaz-Vargas Mayra , Murakami Alice Eiko , Pintro Paula Toshimi Matumoto , Ospina-Rojas Ivan Camilo , de Souza Caio Henrique Pereira , Eyng Cinthia 
Published: June 2018

The objective of this study was to evaluate the effects of citrus pulp in diet for broilers on weight of gastrointestinal organs, intestinal morphometry, and quality and lipid oxidation of broiler meat during the storage time. A total of 966 Cobb male broiler chicks were fed six increasing levels of dietary citrus pulp (0%, 2%, 4%, 6%, 8%, and 10%) with seven replications of 23 birds each. The inclusion of citrus pulp in the diet of broilers from 1 to 21 d of age did not significantly affect organ weight and intestinal morphology (P > 0.05). However, the citrus pulp can be used up to 10% inclusion in diets for broilers from 1 to 42 d of age, without impairing broiler performance, carcass yield, intestinal morphometry, and meat quality. For lipid oxidation, samples of thigh were used in a 6 × 4 factorial design (six dietary levels of citrus pulp and four storage periods) with four replications. In the treatments with 10% citrus pulp, the phenolic compounds present in the by-product led to a delayed and reduced oxidation.
Infrared spectroscopy estimation methods for water-dissolved carbon and amino sugars in diverse Canadian agricultural soils
Authors: Zhang Lei , Yang Xueming , Drury Craig , Chantigny Martin , Gregorich Edward , Miller Jim , Bittman Shabtai , Reynolds W. Dan , Yang Jingyi 
Published: June 2018

Infrared spectroscopy has the potential to rapidly analyse soil water-dissolved carbon and amino sugars. In this study, mid-infrared (MIR) and near-infrared (NIR) spectra collected from soil water extracts or from bulk soils were analysed with partial least squares regression (PLSr) to estimate the concentrations of water-dissolved carbon and amino sugars in diverse agricultural soils collected from five field sites in two western and two eastern Canadian provinces. The MIR-PLSr models developed from soil water extract spectra estimated hot-water (100 °C) dissolved carbon (HWDC) [R2 = 0.97–0.70, ratio of prediction to deviation (RPDp) = 6.13–1.83] well, but the MIR-PLSr models did not estimate cold-water (21 °C) dissolved carbon (CWDC) well (R2 = 0.82–0.50, RPDp = 2.35–1.42). The model estimates of HWDC at the multisite scale (all samples together) and for the two western Canada sites (R2 = 0.97–0.93, RPDp = 6.13–3.68) surpass the modal estimates for the three eastern Canadian sites (R2 = 0.81–0.70, RPDp = 2.28–1.83). The MIR- and NIR-PLSr models derived from bulk soil spectra both estimated HWDC well at the multisite scale (R2 = 0.91–0.88, RPDp = 3.32–2.90) and for the western Canada sites (R2 = 0.90–0.87, RPDp = 3.18–2.96). Models developed from hot-water extract spectra and bulk soil spectra resulted in poor estimates of soil amino sugars (R2 = 0.74–0.21, RPDp = 1.99–1.12), except for the approximate quantitative estimation of muramic acid by models based on soil spectra at the western and the multisite scale (R2 = 0.82–0.80, RPDp = 2.33–2.21). We concluded that MIR and NIR models at regional and multisite scales can be used as a tool to monitor HWDC but that additional research is required for estimating soil amino sugars.
Study of the characteristics of 976 nm Bragg grating external cavity semiconductor lasers
Authors: Yan Zhong-Hua , Zhou Shuai 
Published: June 2018

976 nm fiber Bragg grating (FBG) external cavity laser is the core component in erbium-doped fiber amplifiers (EDFA). In this paper, the theory model of FBG is modeled by transfer matrix method (TMM). The effects of Bragg grating length and modulation depth on the reflectivity, grating spectrum width and wavelength have been investigated. Then 976 nm laser modules with different grating reflectivity, i.e. 4%, 6%, 8% and 10% have been fabricated. By improving the reflectivity of FBG, the side-mode suppression ratio (SMSR) has been optimized to above 40 dB, and the threshold current decreases. The temperature cycling test indicates that the peak wavelength has a change rate [Formula: see text]0.0095 nm/[Formula: see text]C.
Study of the effect of surfactants on hydroxyl radicals in Ag–Ce–ZnO nanocomposites
Authors: Qin Yu-Shan , Shi Qi , Lv Yu-Guang , Shi Chen-Xi , Zhao Ya-Xin , Zhou Zi-Ran , Lin Peng 
Published: June 2018

In this paper, Ag–Ce–ZnO nanocomposites with average particle size of about 50 nm were prepared by direct precipitation method. In order to solve the problem of agglomeration, the nanocomposites with the average particle size of about 30 nm were obtained by treating the nanocomposites with surfactant sodium polyacrylate (PAAS). The effect of surfactant PAAS on the content of hydroxyl radicals produced by nanocomposites was determined by UV spectrophotometry and fluorescence spectrophotometry, and the effect of PAAS on the dispersion effect was obtained indirectly. The experimental results showed that the addition of surfactants’ PAAS effectively reduced the average particle size of nanocomposites, increased the content of hydroxyl radicals, and made the nanocomposites have good dispersing effect.
Idiothetic signal processing and spatial orientation in patients with unilateral hippocampal sclerosis
Authors: Anagnostou Evangelos , Skarlatou Vasiliki , Mergner Thomas , Anastasopoulos Dimitri 
Published: June 2018

The role of the hippocampus in spatial navigation and the presence of vestibular-responsive neurons in limbic areas are well-established from animal experiments. However, hippocampal spatial processing in humans is not fully understood. Here, we employed real whole body and head-on-trunk rotations to investigate how vestibular signals, either alone or in combination with neck-proprioceptive stimulation, shape the spatial frame of reference in patients with unilateral hippocampal sclerosis (HS). Patients were asked to point in darkness with a light spot, moved on a cylindrical screen by means of a joystick, into their visual straight-ahead direction (VSA), to remember this direction in space, and to revert back to this point after the rotations. Estimates in patients with HS were compared with those of healthy controls and of patients with epilepsy without hippocampal involvement. All groups produced similar errors after low-frequency vestibular stimuli. These errors were eliminated when rotations involved concurrent neck stimulation. Significantly increased variability was observed, however, in both the VSA and reposition estimates after the rotations in patients with HS compared with controls. These results suggest that cognitive processing of idiothetic signals for self-motion perception is inaccurate in patients with HS. Importantly, however, the responses of patients with HS showed no spatial lateralization with regard to right or left HS, suggesting that the underlying neuronal loss attenuates the precision of head-direction signal decoding in a nondirectional manner. Hence, patients are unable to use these signals as efficiently as normal subjects in the construction of a stable head-centric spatial frame of reference.NEW & NOTEWORTHY Spatial perception relies on combined processing of various idiothetic (vestibular and proprioceptive) and allothetic (visual and auditory) sensory signals. Despite the established knowledge of rodent vestibular-hippocampal interactions, human data are lacking. We investigated idiothetic orientational processing in subjects with unilateral hippocampal sclerosis using various combinations of vestibular and proprioceptive stimuli. Hippocampal impairment leads to less accurate, noisy decoding of the signal related to idiothetic orientation. However, patients did not show any lateralized deficits of visual straight-ahead perception or of target/self-displacement perception after idiothetic stimulation.