bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consecutive Integers with Close Kernels
Authors: De Koninck Jean-Marie , Luca Florian 
Published: October 2018

AbstractLet $k$ be an arbitrary positive integer and let $\unicode[STIX]{x1D6FE}(n)$ stand for the product of the distinct prime factors of $n$. For each integer $n\geqslant 2$, let $a_{n}$ and $b_{n}$ stand respectively for the maximum and the minimum of the $k$ integers $\unicode[STIX]{x1D6FE}(n+1),\unicode[STIX]{x1D6FE}(n+2),\ldots ,\unicode[STIX]{x1D6FE}(n+k)$. We show that $\liminf _{n\rightarrow \infty }a_{n}/b_{n}=1$. We also prove that the same result holds in the case of the Euler function and the sum of the divisors function, as well as the functions $\unicode[STIX]{x1D714}(n)$ and $\unicode[STIX]{x1D6FA}(n)$, which stand respectively for the number of distinct prime factors of $n$ and the total number of prime factors of $n$ counting their multiplicity.
Evaluation of ORCHIDEE-MICT-simulated soil moisture over China and impacts of different atmospheric forcing data
Authors: Yin Zun , Ottlé Catherine , Ciais Philippe , Guimberteau Matthieu , Wang Xuhui , Zhu Dan , Maignan Fabienne , Peng Shushi , Piao Shilong , Polcher Jan , Zhou Feng , Kim Hyungjun ,   other China-Trend-Stream project members
Published: October 2018

Abstract. Soil moisture is a key variable of land surface hydrology, and its correct representation in land surface models is crucial for local to global climate predictions. The errors may come from the model itself (structure and parameterization) but also from the meteorological forcing used. In order to separate the two source of errors, four atmospheric forcing datasets, GSWP3 (Global Soil Wetness Project Phase 3), PGF (Princeton Global meteorological Forcing), CRU-NCEP (Climatic Research Unit-National Center for Environmental Prediction), and WFDEI (WATCH Forcing Data methodology applied to ERA-Interim reanalysis data), were used to drive simulations in China by the land surface model ORCHIDEE-MICT(ORganizing Carbon and Hydrology in Dynamic EcosystEms: aMeliorated Interactions between Carbon and Temperature). Simulated soil moisture was compared with in situ and satellite datasets at different spatial and temporal scales in order to (1) estimate the ability of ORCHIDEE-MICT to represent soil moisture dynamics in China; (2) demonstrate the most suitable forcing dataset for further hydrological studies in Yangtze and Yellow River basins; and (3) understand the discrepancies of simulated soil moisture among simulations. Results showed that ORCHIDEE-MICT can simulate reasonable soil moisture dynamics in China, but the quality varies with forcing data. Simulated soil moisture driven by GSWP3 and WFDEI shows the best performance according to the root mean square error (RMSE) and correlation coefficient, respectively, suggesting that both GSWP3 and WFDEI are good choices for further hydrological studies in the two catchments. The mismatch between simulated and observed soil moisture is mainly explained by the bias of magnitude, suggesting that the parameterization in ORCHIDEE-MICT should be revised for further simulations in China. Underestimated soil moisture in the North China Plain demonstrates possible significant impacts of human activities like irrigation on soil moisture variation, which was not considered in our simulations. Finally, the discrepancies of meteorological variables and simulated soil moisture among the four simulations are analyzed. The result shows that the discrepancy of soil moisture is mainly explained by differences in precipitation frequency and air humidity rather than differences in precipitation amount.
The internal structure of the Brunt Ice Shelf from ice-penetrating radar analysis and implications for ice shelf fracture
Authors: King Edward C. , De Rydt Jan , Gudmundsson G. Hilmar 
Published: October 2018

Abstract. The rate and direction of rift propagation through ice shelves
depend on both the stress field and the heterogeneity (or otherwise) of the
physical properties of the ice. The Brunt Ice Shelf in Antarctica has
recently developed new rifts, which are being actively monitored as they
lengthen and interact with the internal structure of the ice shelf. Here we
present the results of a ground-penetrating radar survey of the Brunt Ice
Shelf aimed at understanding variations in the internal structure. We find
that there are flow bands composed mostly of thick (ca. 250 m) meteoric ice
interspersed with thinner (ca. 150 m) sections of ice shelf that have a large
proportion of sea ice and seawater-saturated firn. Therefore the ice shelf
is, in essence, a series of ice tongues cemented together with ice
mélange. The changes in structure are related both to the thickness and
flow speed of ice at the grounding line and to subsequent processes of firn
accumulation and brine infiltration as the ice shelf flows towards the
calving front. It is shown that rifts propagating through the Brunt Ice Shelf
preferentially skirt the edges of blocks of meteoric ice and slow their rate
of propagation when forced by the stress field to break through them, in
contrast to the situation on other ice shelves where rift propagation speeds
up in meteoric ice.
Political Economy of Coal Mining Policy: A Case Study in Rent Seeking of Surveyor’s Data Manipulation in East Kalimantan (2009-2014)
Authors: Arwanto Bambang 
Published: October 2018

Both rent seeking and mining policy are two interesting discourses which have enriched the Indonesian policy studies within last two decades. One of prominent problems in this sector is formulation policy process of mining permit (IUP). The concern of mining sector is because the huge economic incentive behind mining business including coal mining. Since the economic incentive is extremely high, the rent seeking is getting higher and more competitive. The competition on rent seeking contest is developed in different policy formulation stages through the elites of business people and bureaucrats.The consequences are the objectivity on issuing the coal mining policy, including extra regulation about surveyors. The policy formulation in this very case produces the dynamic and complex rent seeking activity among the main players. This study is aimed to reveal the case of rent seeking using surveyors on coal mining policy. Using qualitative method and non positivist approach, this case of study was one of five studies that tried to understand the social relationship among the policy actors during mining policy formulation.Findings in the study were: (i) the role of surveyors as “third person” as mediator who played prominent roles in delivering the interest and determined the data through surveyor’s report, (ii) bargaining power of the businessman to get access in penetrating the bureaucracy through bribing and lobbying, and (iii) the role of bureaucrat in manipulating regulation to accommodate their interest through extra regulation making.
O PORTUGUÊS COMO LÍNGUA DE HERANÇA NA GUIANA FRANCESA: ENTRE REALIDADES E POTENCIALIDADES
Authors: Silva Karen Kennia Couto 
Published: October 2018

O aumento dos fluxos migratórios internacionais e o crescente estabelecimento de comunidades de imigrantes no exterior têm suscitado estudos que buscam compreender não somente as causas e os perfis migratórios, mas também questões relacionadas aos direitos do imigrante/emigrante para uma melhor inserção social dessas comunidades. Ademais, desde a Declaração Universal dos Direitos Linguísticos (UNESCO, 1996), tem sido demandada aos Estados a necessidade de assegurar tais direitos por meio de políticas públicas. Nesse sentido, o presente artigo tem como objetivo apresentar e descrever um dispositivo de política linguística francesa em favor do português como língua de herança na Guiana Francesa: a Section Internationale Brésilienne do Lycée Melkior-Garré. Para tanto, em um primeiro momento, procuraremos contextualizar a política linguística enquanto política pública, com o intuito de melhor compreender o nosso objeto de estudo. Em seguida, apresentaremos diferentes definições de língua de herança (LH), ressaltando as diversas nomenclaturas adotadas e os diferentes contextos de uso em estudos da área da Linguística Aplicada. A partir desse percurso, argumentaremos que a Section Internationale Brésilienne do Lycée Melkior-Garré é uma importante experiência de ensino de português na Guiana Francesa, na qual o governo brasileiro pode se apoiar para conformar sua própria política com vistas à promoção do português como língua de herança.
APRESENTAÇÃO - PORTUGUÊS COMO LÍNGUA ADICIONAL EM CONTEXTOS DE MINORIAS: (CO)CONSTRUINDO SENTIDOS A PARTIR DAS MARGENS
Authors: Cossi Bizon Ana Cecília , Diniz Leandro Rodrigues Alves 
Published: October 2018

DOSSIÊ: PORTUGUÊS COMO LÍNGUA ADICIONAL EM CONTEXTOS DE MINORIAS: (CO)CONSTRUINDO SENTIDOS A PARTIR DAS MARGENS Organizadores:Ana Cecília Cossi Bizon (Instituto de Estudos da Linguagem –Unicamp)Leandro Rodrigues Alves Diniz (Faculdade de Letras - UFMG)
Effect of implementing infection control guidelines on minimizing surgical wound infection for patients undergoing neurosurgery
Authors: Abdelmowla Rasha Ali Ahmed , Essa Abdelhakeem A. 
Published: October 2018

Background and objective: Nursing role delivered at all levels of care is critical to eliminate surgical wound infection after neurosurgery. Aim: Evaluate the effect of implementing infection control guidelines on minimizing surgical wound infection for patients undergoing neurosurgery.Methods: Pretest/posttest was used to assess and evaluate nurses' practices pre and post implementation of infection control guidelines while posttest only was used for patients to evaluate the effect of implementing infection control guidelines on minimizing surgical wound infection. Thirty-six nurses in neurosurgery department at Assiut Neurological, Psychiatric and Neurosurgery University Hospital, also 443 patients undergoing neurosurgery were included. Nurses' practices were assessed pre and post implementation of infection control guidelines. Tools: Nurses' observation checklist, patients’ assessment sheet, patients’ follow up sheet and neurosurgery infection control guidelines (teaching booklet) for nurses. Results: Nurses’ practices were improved, infection in neurosurgery was eradicated according to results of environmental swabs and surgical wound infection was reduced post implementation of infection control guidelines.Conclusion and recommendation: Proper implementation of disinfection and sterilization enhance safe and effective care. Infection control policy should be developed in neurosurgery department and all healthcare team should be responsible to adhere and implement it.
A Comparison of Limb Salvage Versus Amputation for Nonmetastatic Sarcomas Using Patient-reported Outcomes Measurement Information System Outcomes
Authors: Wilke Benjamin , Cooper Anna , Scarborough Mark , Gibbs Parker , Spiguel Andre 
Published: October 2018

Introduction:
The Patient-reported Outcomes Measurement Information System (PROMIS) is a scoring tool that allows comparisons between patients with rare conditions and more common ailments, or the general US population. PROMIS outcomes were compared between the limb salvage and amputee patients for nonmetastatic sarcomas to the US population.

Methods:
One hundred thirty-eight patients were included in the analysis. Patients were divided into the limb salvage and amputee cohorts, as well as based on the follow-up (1 to 11 or 12+ months).

Results:
Seven PROMIS domains were evaluated, and higher scores were found in both the limb salvage group and patients >12 months from surgery. The limb salvage group also had improved emotional health compared with the US population.

Discussion:
Improvements in PROMIS values are observed in limb salvage patients and in patients >12 months from surgery. Limb salvage patients demonstrate improved emotional health compared with the US population.
Mutational spectrum and deep intronic variants in the factor VIII gene of haemophilia A patients
Authors: Oldenburg J. , Müller C. R. , Rost S. , Bach J. E. 
Published: October 2018

SummaryHaemophilia A (HA) is caused by a broad spectrum of different mutation types in the factor VIII gene (F8). In our patient cohort of more than 2600 HA patients as well as in other published studies, the most frequent cause are missense mutations in different F8 exons or the recurrent intron 22 inversion. Some exons and several specific nucleotide positions represent hot spots for point mutations in the examined cohort. About 4 % of cases remain without mutation after routine HA diagnostic methods including inversion PCRs, Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA). Deep intronic mutations cannot be detected by current standard HA diagnostics but have been reported for several genetic disorders. However, next generation sequencing (NGS) of the whole genomic sequence of the F8 gene allows to identify deep intronic variants. Conclusion: In general, NGS provides an effective approach to screen for different HA causing mutation types in the F8 gene.
Peculiar laboratory phenotype/ genotype relationship due to compound inherited protein C defects in a child with severe venous thromboembolism
Authors: Bulato Cristiana , Campello Elena , Gavasso Sabrina , Maggiolo Sara , Tormene Daniela , Simioni Paolo 
Published: October 2018

SummaryA 7-years-old child who developed unprovoked deep vein thrombosis (DVT) and pulmonary embolism (PE) was tested for inherited thrombophilia. Protein C (PC) antigen level (87 %) and PC coagulometric and amidolytic activities (12 % and 11 %, respectively) were consistent with a homozygous PC type IIA phenotype.The patient was carrier of two heterozygous missense mutations causing p.Arg32Cys substitution associated with a type I PC defect (“null allele”, from the paternal side) and p.Gly433Ser substitution responsible for a type IIA PC defect (from the maternal side). Thus, the apparently normal PC antigen level in the proband was misleading in the interpretation of phenotype/genotype relationship of this compound PC defect. The child was also carrier of heterozygous prothrombin G20210A variant.Severe venous thromboembolism can occur in otherwise healthy children with complex inherited thrombophilia. Careful laboratory characterization of the phenotype/genotype relationship can be crucial to correctly classify PC defects and for their management with anticoagulants or replacement therapy.
Congenital hypofibrinogenemia associated with γK232T
Authors: Misheng Zhao , Mingshan Wang , Zhefeng Lou , Xiaoli Chen , Dandan Yu , Xiaolong Li , Wenli Xia , Han Wang , Shenmeng Gao , Liqing Zhu 
Published: October 2018

SummaryWe have previously reported a case of congenital hypofibrinogenemia caused by a novel heterozygous A→C transition at nucleotide 5864 of FGG, leading to the K232T substitution in the fibrinogen γ-chain. However, the pathogenic mechanism is still unclear. To further reveal its molecular basis, we examined the effects of γK232T substitution on fibrinogen synthesis, stability, and secretion through in vitro expression of mutant γ232T in Chinese hamster ovary (CHO) cells. Quantitative RT-PCR of the variant γ-chain mRNA showed that the γ232T transcribed the variant cDNA. Enzyme-linked immunosorbent assay and Western blot analysis of the cell lysates and culture media showed that the CHO cells transfected with successfully synthesized the variant fibrinogen, but failed to secrete it into the culture medium. Furthermore, fibrinogen purified from the plasma of patient showed a normal thrombin-catalyzed fibrin polymerization, also indicating the impeding secretion of variant γ232T fibrinogen. In conclusion, our data reveal that the γK232T is responsible for the congenital hypofibrinogenaemia through interfering with the correct secretion of fibrinogen.
Discrimination and Quantification of Moroccan Gasoline Adulteration with Diesel Using Fourier Transform Infrared Spectroscopy and Chemometric Tools
Authors: Barra Issam , Mansouri Mohammed Alaoui , Bousrabat Mohammed , Cherrah Yahia , Bouklouze Abdelaziz , Kharbach Mourad 
Published: October 2018

Abstract
In this work, transform-infrared spectroscopy (FTIR) was associated with chemometric tools, especially principal component analysis (PCA) and partial least squares regression (PLSR), to discriminate and quantify gasoline adulteration with diesel. The method is composed of a total of 100 mixtures were prepared, and then FTIR fingerprints were recorded for all samples. PCA was used to verify that mixtures can be distinguished from pure products and to check that there are no outliers. As a result of using just PC1 and PC2, more than 98% of the general variability was explained. The PLSR model based on infrared spectra has shown its capabilities to be suitable for predicting gasoline adulteration in the concentration range of 0 to 98% (w/w), with a high significant coefficient of determination (R2 = 99.25%) and an acceptable calibration and prediction errors (root mean squared error of calibration = 0.63 and root mean square of external validation and/or prediction = 0.69).
Duodenal Epithelial Polyps: A Clinicopathologic Review
Authors: Collins Katrina , Ligato Saverio 
Published: October 2018

Context.—
Duodenal epithelial polyps are reported in 1.5% to 3% of individuals referred for upper endoscopy. Most duodenal epithelial polyps are asymptomatic and nonneoplastic; however, a small subset is neoplastic and may progress to adenocarcinoma. Recent advances in immunohistochemical and molecular techniques have helped further characterize these polyps, shedding light on their origin, classification, and risk of progression to adenocarcinoma.

Objective.—
To provide a comprehensive clinicopathologic review of nonneoplastic and neoplastic duodenal epithelial polyps, with particular emphasis on recent developments in classification schemes and risk stratification based upon immunohistochemical and molecular profiles.

Data Sources.—
This review is based on peer-reviewed literature and the authors' experiences.

Conclusions.—
In this review we provide an update on the clinicopathologic, immunohistochemical, and molecular features of duodenal epithelial polyps and discuss the surveillance recommendations and treatment options available. Particular attention should be placed on recognizing duodenal adenomas with intestinal, gastric, and serrated phenotype, as they have an increased risk of malignant transformation if not completely excised.
Spinal Radiographic Progression in Early Axial Spondyloarthritis: Five‐Year Results From the DESIR Cohort
Authors: Ramiro Sofia , van der Heijde Désirée , Sepriano Alexandre , van Lunteren Miranda , Moltó Anna , Feydy Antoine , d'Agostino Maria Antonietta , Loeuille Damien , Dougados Maxime , Reijnierse Monique , Claudepierre Pascal 
Published: October 2018

ObjectiveTo analyze the progression of spinal radiographic damage in patients with early axial spondyloarthritis (SpA).MethodsAxial SpA patients from the DESIR (Devenir des Spondylarthropathies Indifférenciées Récentes) cohort with 5‐year spinal (cervical and lumbar) radiographs available (n = 549) were included. Two‐ and 5‐year modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) progression and development of new syndesmophytes (net change: the number of patients with positive change minus the number of patients with negative change divided by the total number of patients) were assessed in subgroups defined at baseline according to the Assessment of SpondyloArthritis international Society axial SpA criteria and its arms, modified New York criteria (mNYC) and the presence of syndesmophytes.ResultsMean ± SD mSASSS progression was 0.2 ± 0.9 at 2 years and 0.4 ± 1.8 at 5 years. Five‐year progression was higher in the imaging arm (mean ± SD 0.6 ± 2.3), magnetic resonance imaging (MRI)+/mNYC+ (mean ± SD 1.3 ± 4.0), than in the clinical arm only (mean ± SD 0.1 ± 0.7), and highest in patients with syndesmophytes (mean ± SD 2.7 ± 5.0). At 5 years, 7% of all patients had a net change of any new syndesmophyte; this value was 10% for the imaging arm (mNYC+/MRI+ with 18%), 17% for mNYC+ patients, and 42% for patients with syndesmophytes.ConclusionSpinal radiographic progression, although limited in early axial SpA, can be captured after 2 years. Inflammation and damage in the sacroiliac joint are associated with higher radiographic progression. The presence of baseline syndesmophytes already strongly predicts the development of further structural damage early in the disease.
International Consortium for Health Outcome Measurement Set of Outcomes That Matter to People Living With Inflammatory Arthritis: Consensus From an International Working Group
Authors: Oude Voshaar Martijn A. H. , Das Gupta Zofia , Bijlsma Johannes W. J. , Boonen Annelies , Chau Jeffrey , Courvoisier Delphine S. , Curtis Jeffrey R. , Ellis Benjamin , Ernestam Sofia , Gossec Laure , Hale Christine , Hornjeff Jennifer , Leung Katy Y. Y. , Lidar Merav , Mease Phillip , Michaud Kaleb , Mody Girish M. , Ndosi Mwidimi , Opava Christina H. , Pinheiro Geraldo R. C. , Salt Matthew , Soriano Enrique R. , Taylor William J. , Voshaar Maria J. H. , Weel Angelique E. A. M. , de Wit Maarten , Wulffraat Nico , van de Laar Mart A. F. J. , Vonkeman Harald E. 
Published: October 2018

ObjectiveThe implementation of value‐based health care in inflammatory arthritis requires a standardized set of modifiable outcomes and risk‐adjustment variables that is feasible to implement worldwide.MethodsThe International Consortium for Health Outcomes Measurement (ICHOM) assembled a multidisciplinary working group that consisted of 24 experts from 6 continents, including 6 patient representatives, to develop a standard set of outcomes for inflammatory arthritis. The process followed a structured approach, using a modified Delphi process to reach consensus on the following decision areas: conditions covered by the set, outcome domains, outcome measures, and risk‐adjustment variables. Consensus in areas 2 to 4 were supported by systematic literature reviews and consultation of experts.ResultsThe ICHOM Inflammatory Arthritis Standard Set covers patients with rheumatoid arthritis (RA), axial spondyloarthritis, psoriatic arthritis, and juvenile idiopathic arthritis (JIA). We recommend that outcomes regarding pain, fatigue, activity limitations, overall physical and mental health impact, work/school/housework ability and productivity, disease activity, and serious adverse events be collected at least annually. Validated measures for patient‐reported outcomes were endorsed and linked to common reporting metrics. Age, sex at birth, education level, smoking status, comorbidities, time since diagnosis, and rheumatoid factor and anti‐citrullinated protein antibody lab testing for RA and JIA should be collected as risk‐adjustment variables.ConclusionWe present the ICHOM inflammatory arthritis Standard Set of outcomes, which enables health care providers to implement the value‐based health care framework and compare outcomes that are important to patients with inflammatory arthritis.