bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pollen sleuthing for terrestrial plant surveys: Locating plant populations by exploiting pollen movement
Authors: Campbell Lesley G. , Melles Stephanie J. , Vaz Eric , Parker Rebecca J. , Burgess Kevin S. 
Published: February 2018

Premise of the StudyWe present an innovative technique for sampling, identifying, and locating plant populations that release pollen, without extensive ground surveys. This method (1) samples pollen at random locations within the target species’ habitat, (2) detects species’ presence using morphological pollen analysis, and (3) uses kriging to predict likely locations of populations to focus future search efforts.MethodsTo demonstrate, we applied the pollen sleuthing system to search for artificially constructed populations of Brassica rapa in an old field. Population size varied from 0–100 flowers labeled with artificial pollen (paint pellets). After characterizing the landscape, we pan‐trapped 2762 potential insect vectors from random locations across the field and washed particulate matter from their bodies to assess artificial pollen abundance with a microscope.ResultsPopulation size greatly influenced artificial pollen detection success; following random pollen trap sampling and interpolation, ground surveys would be best focused on identified areas with high pollen density and low variation in pollen density. Sampling sites most successfully detected artificial pollen when they were located at higher elevations, near showy flowering plants that were not grasses.DiscussionDetection of nascent populations using the proposed system is possible but accuracy will depend on local environmental factors (e.g., wind, elevation). Conservation and invasive species control programs may be improved by using this approach.
Anatomical Basis of Differences in Locomotor Behavior in Martens: AComparison of the Forelimb Musculature Between Two Sympatric Species of Martes
Authors: Böhmer Christine , Fabre Anne‐Claire , Herbin Marc , Peigné Stéphane , Herrel Anthony 
Published: February 2018

ABSTRACTArboreal locomotion imposes selective pressures that may affect the evolution of the locomotor apparatus. The limbs have to be mobile to reach across discontinuities, yet at the same time need to be forceful to move against gravity during climbing. However, as intermediaries between the arboreal and terrestrial environment, semi‐arboreal mammals appear not extremely specialized and, thus, anatomical adaptations may be less evident than expected for arboreal climbers. Here, we present quantitative data on the muscle anatomy of the forelimbs (N = 14) of two closely related species of Mustelidae and relate the findings to their locomotor habits. The arboreal pine marten (Martes martes) and the more terrestrial stone marten (Martes foina) are the most similar sympatric carnivores in Europe, but distinctly differ in habitat selection and locomotor mode. Via dissections muscle architectural variables including muscle mass, pennation angle, and fiber length were measured and the physiological cross‐sectional area and maximum isometric force were estimated for each muscle. The results reveal that the force‐generating capacity of the limb flexor and retractor muscles and the excursion capability of the adductor muscles are greater in the pine marten compared to the stone marten. Since the two sympatric martens are very similar in terms of overall appearance, body size, intra‐limb proportions, phylogenetic relationships and predation behavior, the differences in forelimb musculature are interpreted to reflect the greater climbing ability of the pine marten. The functional properties appear to facilitate locomotion in a three‐dimensionally complex arboreal environment. Anat Rec, 301:449–472, 2018. © 2018 Wiley Periodicals, Inc.
Einfluss von Wärmedämm‐Verbundsystemen auf die Schalldämmung von Außenwänden
Authors: Weber Lutz , Müller Simon , Kaltbeitzel Bernd 
Published: February 2018

AbstractWärmedämm‐Verbundsysteme (WDVS) verbessern die thermische Isolation der Gebäudehülle und liefern damit einen wichtigen Beitrag zur Einsparung von Heizenergie. Sie wirken sich jedoch außerdem in erheblichem Maße auf die akustischen Eigenschaften der Außenwände aus, wobei je nach Ausführung sowohl eine Verbesserung als auch eine Verschlechterung der Schalldämmung erfolgen kann. Deshalb wurden bereits vor etwa fünfzehn Jahren Planungswerkzeuge entwickelt, mit denen sich die Schalldämmung von Wänden mit WDVS zuverlässig vorherberechnen lässt. Die hierzu verwendeten Berechnungsmodelle sind bis heute im Einsatz. Da sich die Bauweise von Außenwänden infolge der verschärfen Anforderungen an den Wärmeschutz seither erheblich verändert hat, waren ergänzende Untersuchungen erforderlich, um die bestehenden Modelle an die aktuellen Bauweisen anzupassen. In dem Beitrag werden die Ergebnisse des hierzu durchgeführten Forschungsvorhabens beschrieben, wobei der derzeitige Wissenstand zur Schalldämmung von Wänden mit WDVS in einer Übersicht zusammengefasst und auch auf den akustischen Einfluss von WDVS im Kontext der baulichen Gesamtsituation sowie auf die Bedeutung von Spektrum‐Anpassungswerten für den baulichen Schallschutz eingegangen wird. Eine Übersicht über sämtliche zur Vorhersage der Schalldämmung erforderlichen Formeln erleichtert die praktische Anwendung der entwickelten Berechnungsverfahren.
Lecture capture use in engineering education: Influence of students’ social and behavioral factors and teachers’ perceptions
Authors: Rahman Anisur , Shah Mohammad Aminur Rahman , Chowdhury Sanaul Huq 
Published: February 2018

AbstractThis paper discusses the influence of students’ social and behavioral features on lecture capture use in the learning of engineering courses, as well as teachers’ perceptions of pedagogical changes and students’ performance. Results show that the students’ perceptions about lecture capture are highly positive in terms of improving learning and academic performance. With respect to behavioral factors like attention deficit, the study suggests that a significant number of students having difficulties in maintaining attention during lectures and rely on lecture capture for further understanding. With respect to social factors, variation in the use of lecture capture has also been observed between native and non‐native English speaking students, and in students with different levels of past experience in using lecture capture. Lecturers of these engineering courses have expressed optimism about using lecture capture, and have raised concerns about restrictive teaching styles, and the requirement for technological improvements and adequate training.
The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases
Authors: Chiaratti Marcos Roberto , Garcia Bruna Martins , Carvalho Karen Freire , Machado Thiago Simões , Ribeiro Fernanda Karina da Silva , Macabelli Carolina Habermann 
Published: February 2018

AbstractMitochondria play a fundamental role during development of the female germline. They are fragmented, round, and small. Despite these characteristics suggesting that they are inactive, there is accumulating evidence that mitochondrial dysfunctions are a major cause of infertility and generation of aneuploidies in humans. In addition, mitochondria and their own genomes (mitochondrial DNA—mtDNA) may become damaged with time, which might be one reason why aging leads to infertility. As a result, mitochondria have been proposed as an important target for evaluating oocyte and embryo quality, and developing treatments for female infertility. On the other hand, mutations in mtDNA may cause mitochondrial dysfunctions, leading to severe diseases that affect 1 in 4,300 people. Moreover, very low levels of mutated mtDNA seem to be present in every person worldwide. These may increase with time and associate with late‐onset degenerative diseases such as Parkinson disease, Alzheimer disease, and common cancers. Mutations in mtDNA are transmitted down the maternal lineage, following a poorly understood pattern of inheritance. Recent findings have indicated existence in the female germline of a purifying filter against deleterious mtDNA variants. Although the underlying mechanism of this filter is largely unknown, it has been suggested to rely on autophagic degradation of dysfunctional mitochondria or selective replication/transmission of non‐deleterious variants. Thus, understanding the mechanisms regulating mitochondrial inheritance is important both to improve diagnosis and develop therapeutic tools for preventing transmission of mtDNA‐encoded diseases.
Patent Blue dye allergy and the deep inferior epigastric perforator free flap: a unique interaction
Authors: Kumar Shanesh , Dhillon Raminder , Shah Snehal , White Dean C. , Rozen Warren Matthew 
Published: February 2018

Key Clinical MessagePatent Blue dye for sentinel lymph node biopsy is associated with systemic allergic response and generalized blue hue. We report a unique case of successful free flap transfer in this setting. Despite inotropic support and abnormal blue hue, allergic response does not preclude safe flap transfer and monitoring.
Detectability of concentration‐dependent factors by application of PCA. An indicator curve for the determination of important principal components and a post‐correction for transformation of principal components to factors
Authors: Németh Zsolt István , Rákosa Rita 
Published: February 2018

AbstractA semi empirical model of light absorption for binary liquid mixtures, which includes linear, parabolic, and periodic terms of concentration‐dependent factors, has been developed and applied for investigating the revealability of the factors. Concentration‐dependent near infrared spectra of ethanol‐water mixtures and a two‐component model were decomposed by principal component analysis. Generated from the principal component analysis results and called the mean coefficient of determination, an indicator is introduced for separating the important or systematic principal components with deterministic information (factor PCs) from stochastic principal components originating from spectral noise (error PCs). Moreover, a post‐correction method is proposed to pull the concentration‐dependent factor effects out of the systematic principal components. The first PC of ethanol‐water NIR mixture spectra defines the contributions of clusters of both water and ethanol molecules in the solution to resultant absorbance signals. The second PC includes partial absorptions from ethanol‐water dimers and ethanol‐water‐ethanol trimers. The third PC is assumed to reflect concentration‐dependent restructuring of mixture structure.
Synthesis of EU‐1/ZSM‐48 Co‐Crystalline Zeolites from High‐Silica EU‐1 Seeds: Tailoring Phase Proportions and Promoting Long Crystalline‐Phase Stability
Authors: Zhang Yafei , Liu Yasheng , Sun Liyuan , Zhang Luoming , Xu Jun , Deng Feng , Gong Yanjun 
Published: February 2018

AbstractA facile, specific, seed‐assisted strategy for the synthesis of EU‐1/ZSM‐48 co‐crystalline zeolites in the presence of hexamethonium ions (HM2+) has been developed. EU‐1/ZSM‐48 co‐crystalline zeolites with various phase proportions, with EU‐1 in the range of 25 wt %–86 wt %, were obtained by adding high‐silica EU‐1 seeds (SiO2/Al2O3 ratio of 300) and adjusting the synthesis parameters. Not only can the phase proportions of EU‐1/ZSM‐48 co‐crystalline zeolites be controlled, but also the stability period for co‐crystallization of the two phases can be extended through varying the amount of EU‐1 seeds and the HM2+ template. Moreover, with the increase of the EU‐1 proportion in the EU‐1/ZSM‐48 co‐crystalline, the framework SiO2/Al2O3 ratios of EU‐1 phase promotes steadily. Major differences in acidity and textural properties of the EU‐1/ZSM‐48 co‐crystalline zeolites (Coz) were found with varying phase proportions, due to their distinct topological structures, crystal morphology and asymmetry between the EU‐1 and ZSM‐48 phases. For instance, the EU‐1/ZSM‐48 zeolite containing 75 wt % of EU‐1 (Coz‐75) possesses specific acidity and mesoporous characteristics, showing an excellent catalytic activity and stability in n‐hexane cracking reaction. Compared to EU‐1, ZSM‐48, and a mechanical mix of the two zeolites (Mix‐75), Coz‐75 resulted in the highest hexane conversion and yields of light olefins, with a propylene yield, in particular, up to 38.3 wt %, which is 6.3 % more than that of the Mix‐75 sample.
Designed ether‐functionalized acidic ionic liquid catalyst for butyl acetate synthesis
Authors: Feng Xiantao , Zhang Cai , Liu Yunling , Zuo Xiaoyong , Shi Haoxiang 
Published: February 2018

AbstractWe design and synthesize 1‐(methoxyethyl)‐3‐methylimidazolium hydrogen sulfate ionic liquid ([MOE‐MIM]HSO4). The ionic liquid is characterized by thermogravimetric analysis, HNMR, 13CNMR, and FTIR spectrum. The synthesis of butyl acetate is based on an orthogonal array experimental design (OA9 matrix). A high conversion rate of acetic acid of 97.72 % is obtained under optimal reaction conditions. In addition, [MOE‐MIM]HSO4 exhibits low solubility in butanol and is immiscible with butyl acetate, thereby making it easily separated from the products. After reuse for five cycles, the catalytic activity of [MOE‐MIM]HSO4 is nearly unchanged.
Pharmacokinetics and Safety of Risperidone Subcutaneous Implants in Stable Patients With Schizophrenia
Authors: Dammerman Ryan , Kim Sonnie , Adera Mathews , Schwarz Alex 
Published: February 2018

AbstractA subcutaneous risperidone implant (RI) formulation was developed to improve medication adherence in schizophrenia. Two phase 1 studies were conducted to evaluate the pharmacokinetics of RI in adult patients with schizophrenia. In study 1, all subjects were stable on 4 mg oral risperidone; subsequently, the first subject received 375 mg RI for 1 month, and the remaining subjects received 375 mg RI for 3 months. In study 2, all subjects were stable on oral risperidone 4 mg, 6 mg, or 8 mg and subsequently received RI 480 mg, 720 mg, or 960 mg, respectively, for 6 months. Blood samples were collected at prespecified time points. Various pharmacokinetic parameters were determined in both studies. In both studies risperidone total active moiety plasma concentrations following RI increased slowly, reached therapeutic levels within approximately 2 days, and remained relatively stable. In study 1, the average concentration for RI was 81.3% of the oral trough concentration and 27.5% of the oral peak concentration. In study 2, the steady‐state concentration for RI was comparable to the oral trough concentration of the corresponding dose. Patient disease status remained stable with no major safety issues. RI may represent an alternative formulation for schizophrenia treatment with a lower peak‐to‐trough plasma drug ratio than oral risperidone.
Computer‐Aided Design and Synthesis of 1‐{4‐[(3,4‐Dihydroxybenzylidene)amino]phenyl}‐5‐oxopyrrolidine‐3‐carboxylic Acid as an Nrf2 Enhancer
Authors: Kahremany Shirin , Babaev Ilana , Hasin Pinhas , Tamir Tigist Y. , Ben‐Zur Tali , Cohen Guy , Jiang Zhengyu , Weintraub Sagiv , Offen Daniel , Rahimipour Shai , Major M. Ben , Senderowitz Hanoch , Gruzman Arie 
Published: February 2018

AbstractThe design and synthesis of a novel nuclear factor erythroid 2‐related factor 2 (Nrf2) enhancer is reported. Using a structure‐based virtual screening approach, several commercially available compounds were identified as having high probability to interact with the Nrf2‐binding pocket in the Kelch‐like ECH‐associated protein 1 (Keap1). Keap1 is an adaptor protein that recruits Nrf2 to a cullin‐3‐dependent ubiquitin ligase complex. The identified compounds were tested against rat pheochromocytoma PC‐12 cells for their cytoprotective activity, and one compound (SKT359126) demonstrated an Nrf2‐mediated cell‐protective effect. Based on the structure of SKT359126, 23 novel derivatives were synthesized and evaluated. Of the screened derivatives, 1‐{4‐[(3,4‐dihydroxybenzylidene)amino]phenyl}‐5‐oxopyrrolidine‐3‐carboxylic acid demonstrated better activity than the parent molecules in activating the Nrf2 transduction pathway in a dose‐ and time‐dependent manner. This compound represents a promising starting point for the development of therapeutics for the treatment of oxidative‐stress‐related diseases.
Photoswitchable Azobenzene/Cyclodextrin Host‐Guest Complexes: From UV‐ to Visible/Near‐IR‐Light‐Responsive Systems
Authors: Wang Dongsheng , Zhao Weifeng , Wei Qiang , Zhao Changsheng , Zheng Yonghao 
Published: February 2018

AbstractUV‐light‐responsive azobenzene (Azo)/cyclodextrin (CD) host‐guest complexes are attractive for designing smart stimuli‐responsive materials, and have been extensively investigated over the past three decades. However, when applied in biomedical fields, as a result of the harmfulness and poor penetrability of UV light to human tissue, Azo/CD host‐guest complexes responsive to light of longer wavelengths is required. In this Minireview, we reviewed the traditional UV‐light‐responsive Azo/CD host‐guest systems and developments to red‐shift the switching light to the visible or even to the near‐infrared (NIR) light region. “Indirect” methods, including upconversion and two‐photon processes, and “direct” methods to chemically modify Azo molecules for red‐shifting the inducing light were summarized and compared. In addition to biomedical applications, we provide an overview of the potential of visible/NIR‐light‐responsive Azo/CD host–guest complexes in the design of intelligent multifunctional supramolecular materials that function through orthogonal light control.
Proactive caching with content‐based pricing for cooperative femtocells in two‐tier heterogeneous networks
Authors: Karar Sandip , Das Barman Abhirup 
Published: February 2018

SummaryWith increase in the number of smart wireless devices, the demand for higher data rates also grows which puts immense pressure to the network. A vast majority of this demand comes from video files, and it is observed that only a few popular video files are requested more frequently during any specified time interval. Recent studies have shown that caching provides a better performance as it minimizes the network load by avoiding the fetching of same files multiple times from the server. In this paper, we propose to combine two ideas; proactive caching of files and content‐based pricing in macro‐femto heterogeneous networks. The femtocell access point (FAP) is allowed to manipulate its users' demand through content‐based pricing and serve the users' requests by proactively downloading suitable content into its cache memory which reduces the load of the femtocell. In addition, an incentive mechanism is also proposed which encourages the FAP to help macrocell users under its coverage zone by allowing access to its cached content and thereby reduces the macrocell load. The proposed content‐based pricing and proactive caching scheme for femtocells is modeled as a Stackelberg game among the macrocell base station and the FAP to jointly maximize both of their utilities. Performance analysis of the scheme is presented for a single femtocell scenario and compared with the conventional flat pricing‐based scheme via numerical examples. The results demonstrate significant reduction in network load using our proposed scheme.
How many individuals achieve symptom abstinence following psychological treatments for bulimia nervosa? A meta‐analytic review
Authors: Linardon Jake , Wade Tracey D. 
Published: February 2018

AbstractObjectivesIt is unclear how many patients with bulimia nervosa (BN) completely abstain from the core behavioral symptoms after receiving psychological treatment. The present meta‐analysis of randomized controlled trials (RCTs) aimed to (a) estimate the prevalence of patients who abstain from binge eating and/or purging following all psychological treatments for BN, and (b) test whether these abstinence estimates are moderated by the type of treatment modality delivered, the definition of abstinence applied, and trial quality.MethodForty‐five RCTs were included, with 78 psychotherapy conditions. Pooled event rates were calculated using random effects models.ResultsAt post‐treatment, the total weighted percentage of treatment‐completers who achieved abstinence was 35.4% (95% CI = 29.6, 41.7), while the total weighted percentage of abstinence for all randomized patients (intention‐to‐treat) was 29.9% (95% CI = 25.7, 33.2). Abstinence estimates were highest in trials that used behavioral‐based treatments (e.g., cognitive–behavioral therapy, behavior therapy). There was also evidence that guided self‐help interventions produced the lowest post‐treatment abstinence rates, but with no difference at follow‐up from clinician‐led treatments, and studies that used a shorter timeframe for defining abstinence (i.e., 14 days symptom‐free compared to 28‐days symptom‐free) produced the highest abstinence rates. Abstinence estimates at follow‐up for both the completer (34.6%; 95% CI = 29.3, 40.2) and intention‐to‐treat (28.6%; 95% CI = 25.1, 32.3) analyses were essentially the same as the post‐treatment estimates.DiscussionOver 60% of patients fail to fully abstain from core BN symptoms even after receiving our most empirically‐supported treatments. The present findings highlight the urgency toward improving the effectiveness of psychological treatments for BN.
A Simple and Highly Selective Determination of Telmisartan at Sodium Dodecyl Sulfate Modified Pyrolytic Graphite Surface
Authors: Kumar Neeraj , Goyal Rajendra N. 
Published: February 2018

AbstractA simple, facile, selective and cost effective electrochemical method is proposed for the determination of telmisartan (TMS); a drug used for hypertension. A sodium dodecyl sulfate (SDS) modified edge plane pyrolytic graphite (EPPG) is prepared by simple immersion of EPPG in SDS solution at concentration greater than critical micelle concentration (CMC). The modified sensor exhibited superior sensing properties towards the oxidation of TMS. The modified surface was characterized by using the Energy dispersive X‐ray analysis, Field Emission Scanning Electron Microscopy, Electrochemical Impedance Spectroscopy and cyclic voltammetry. The quantitative investigations of the TMS were performed by applying the square wave voltammetry. The micelles of SDS form a pseudo complex with cation radical of TMS and catalyse the oxidation. The proposed sensor shows the linear calibration plot in the concentration range of 5–100 μM with sensitivity 0.2983 μA/μM and the limit of the detection of the sensor was found to be 0.082 μM. The specificity of the developed sensor was also evaluated in the presence of commonly present interfering substances in biological samples. The amount of TMS excreted in urine of the patients undergoing treatment has also been determined. The proposed method can be effectively applied for the investigation of TMS in pharmaceutical formulations and biological samples.