bluuebunny/crossref_metadata_2025_split huggingface dataset:
JMJD6 Cleaves MePCE to Release P-TEFb
Authors: Lee Schuyler , Liu Haolin , Hill Ryan , Hong Xia , Liu Xinjian , Crawford Fran , Zhang Qianqian , Kingsley Molly , Chen Zhongzhou , Lengeling Andreas , Bernet Kathrin , Marrack Philippa , Kappler John , Hansen Kirk , Zhou Qiang , Li Chuan-Yuan , Zhang Gongyi 
Published: August 2019

AbstractMore than 30% of genes in higher eukaryotes are regulated by promoter-proximal pausing of RNA polymerase II (Pol II). Phosphorylation of Pol II-CTD by positive transcription elongation factor (P-TEFb) is a necessary precursor event that enables productive transcription elongation. The exact mechanism on how the sequestered P-TEFb is released from the 7SK snRNP complex and recruited to Pol II-CTD remains unknown. In this report, we reveal methylphosphate capping enzyme (MePCE), a core component of the 7SK snRNP complex, as the cognate substrate for Jumonji domain-containing 6 (JMJD6)’s novel proteolytic function. Our evidences consist of a crystal structure of JMJD6 bound to methyl-arginine, enzymatic assays of JMJD6 cleaving MePCE in vivo and in vitro, binding assays, and downstream effects of Jmjd6 knockout and overexpression on Pol II-CTD phosphorylation. We propose that JMJD6 assists bromodomain containing 4 (BRD4) to recruit P-TEFb to Pol II-CTD by disrupting the 7SK snRNP complex.
Reliability of an interneuron response depends on an integrated sensory state
Authors: Dobosiewicz May , Bargmann Cornelia I. 
Published: August 2019

ABSTRACTThe central nervous system transforms sensory information into representations that are salient to the animal. Here we define the logic of this transformation in aCaenorhabditis elegansintegrating interneuron. AIA interneurons receive input from multiple chemosensory neurons that detect attractive odors. We show that reliable AIA responses require the coincidence of two sensory inputs: activation of AWA olfactory neurons that are activated by attractive odors, and inhibition of one or more chemosensory neurons that are inhibited by attractive odors. AWA activates AIA through an electrical synapse, while the disinhibitory pathway acts through glutamatergic chemical synapses. The resulting AIA interneuron responses have uniform magnitude and dynamics, suggesting that AIA activation is a stereotyped response to an integrated stimulus. Our results indicate that AIA interneurons combine sensory information using AND-gate logic, requiring coordinated activity from multiple chemosensory neurons. We propose that AIA encodes positive odor valence based on an integrated sensory state.
The crystal structure of new quantum memory-storage material Sc1.368Y0.632SiO5
Authors: Iskhakova Liudmila D. , Ilyukhin Andrey B. , Kutovoi Sergey A. , Vlasov Victor I. , Zavartsev Yuri D. , Tarasov Valerii F. , Eremina Rushana M. 
Published: August 2019

Monoisotopic scandium yttrium oxyorthosilicate crystals as a material for quantum memory storage with high optical quality were grown by the Czochralski method. This material, of composition Sc1.368Y0.632SiO5, is characterized by congruent melting and a melting point 60 K below the temperature for the ideal solid-solution series Y2SiO5–Sc2SiO5. The structure of the crystals was refined on the basis of high-quality single-crystal X-ray diffraction data. Sc1.368Y0.632SiO5 belongs to B-type RE2SiO5 (space group C2/c). Scandium and yttrium cations are distributed among two 8f sites with coordination numbers 7 and 6 for which the occupancy parameters ratios Sc:Y and average bond lengths are, respectively, 0.473:0.527 and RE1—O = 2.305 (2) Å, and 0.895:0.105 and RE2—O = 2.143 (2) Å. It is shown that the character of the occupancy of the positions of the cations with coordination numbers (CN) 6 and 7 for these solid solutions can be approximated by a polynomial dependence, the magnitude of the coefficients of which depends on the difference in the ionic radii of the cations. A preliminary electron paramagnetic resonance (EPR) study shows that activator ions with a large ionic radius at a concentration less than 0.1% occupy a position with CN = 7.
Discursive framing in private and public communication by pro-nuclear corporate, political and regulatory actors following the Fukushima disaster
Authors: Beelitz Annika , Merkl-Davies Doris M. 
Published: August 2019

Purpose
The purpose of this paper is to examine a case of companies cooperating with the State to prevent a public controversy over nuclear power following the Fukushima disaster and achieve mutually beneficial policy outcomes. It analyses the private and public communication of pro-nuclear corporate, political and regulatory actors.

Design/methodology/approach
Drawing on the political economy theory, the study examines how actors mobilised power by accessing an existing social network to agree a joint public communication strategy in order to ensure public support for the continuation of nuclear power generation in the UK. It traces discursive frames from their inception in private communication to their reproduction in public communication and their dissemination via the media.

Findings
The study provides evidence of pro-nuclear actors cooperating behind the scenes to achieve consistent public pro-nuclear messaging. It finds evidence of four discursive frames: avoiding knee-jerk reactions, lessons learned, safety and nuclear renaissance. In combination, they guide audiences’ evaluation of the consequences of the Fukushima disaster for the UK in favour of continuing the commercial use of nuclear energy.

Originality/value
The private e-mail exchange between pro-nuclear actors presents a unique opportunity to examine the mobilisation of less visible forms of power in the form of agenda setting (manipulation) and discursive framing (domination) in order to influence policy outcomes and shape public opinion on nuclear energy. This is problematic because it constitutes a lack of transparency and accountability on part of the State with respect to policy outcomes and restricts the civic space by curtailing the articulation of alternative interests and voices.
Supplier evaluation and classification in a Colombian motorcycle assembly company using data envelopment analysis
Authors: Restrepo Rodrigo , Villegas Juan G. 
Published: August 2019

PurposeThe purpose of this paper is to present a case study in which data envelopment analysis (DEA) is used to evaluate and classify the suppliers of a Colombian motorcycle assembly company. This tool allows the integration of several attributes into single performance measures (cross-efficiency and diversity efficiency) and subsequent classification based on the values obtained for these two metrics.Design/methodology/approachThe classification uses a methodology based on two main tools. The first is an input-oriented cross-efficiency DEA model with ordinal variables to evaluate the suppliers’ performance, and the second is a classification of these into categories that identifies those with good performance for features that make them outstanding.FindingsThe assembly company segments its suppliers according to supply frequency. The results show that suppliers working under a just-in-time system achieve superior performance with respect to other suppliers.Practical implicationsThe application of this methodology in a real-world case illustrates how DEA can be a useful tool to support the evaluation and classification of suppliers (a process of increasing complexity given the current trend to include multiple strategic measures together with classical operational measures). Moreover, the methodology illustrated in the study can be adapted to other similar settings.Originality/valueThe main contributions of this paper are twofold. First, to the best of our knowledge, this is the first study to illustrate the use of DEA in a real case related to supplier evaluation. Second, the presence of ordinal variables (e.g. quality or environmental ratings) gives rise to DEA variants seldom used in this context.
Modern information warfare: analysis and policy recommendations
Authors: Lei Hanci 
Published: August 2019

PurposeInformation warfare (IW) is a novel and poorly understood threat to the international community, which may be used more commonly as a foreign policy tool in the future. By identifying the key components of modern IW, this paper seeks to formulate policy recommendations for how best to deal with this new threat. The general overview of the topic that this paper provides contributes to current efforts to develop strategies to counter IW operations around the world.Design/methodology/approachThe goal of this paper is to break down the components of modern IW and provide policy recommendations for domestic and international governance on the issue. These recommendations will be based in part of historical initiatives to counter IW and existing literature on cyber governance. Central to the framework used to analyze the cases of Russian and North Korean IW operations are the seven defining features of “strategic” IW established by a 1996 RAND Corporation report, modified to incorporate the importance of cyberspace to cases of IW in the modern day.FindingsModern IW presents a new, multifaceted threat to states. Because of the value of IW as a tool by weaker states to counter stronger ones and the weakness of existing legal and normative frameworks, use of IW can be expected to be increasingly common. States can take action to promote international governance on the issue and develop policy frameworks for protecting themselves against IW.Practical implicationsIW has historically been a very tricky tactic to define and identify. By analyzing IW’s basic features, this paper provides a framework for breaking down IW into its component parts, which reveals valuable policy implications. Preventative efforts against IW can help restore trust to global information networks and lower the risk of conflict.Originality/valueFormal scholarship on modern IW and related subjects is lacking in comparison with higher visibility threats. Increased awareness of this issue, especially amongst civilian leaders, can augment global efforts to counter IW.
Oil price-inflation pass-through in OECD countries
Authors: Adekoya Oluwasegun Babatunde , Adebiyi Anthony Noah 
Published: August 2019

Purpose
This paper aims to assess the relationship between oil price and inflation in the Organization for Economic Co-operation and Development (OECD) countries. This paper contributes to knowledge in a number of ways.

Design/methodology/approach
First, we carry out a comparative analysis between the developed and developing countries of the OECD. Second, we check if the global financial crisis (GFC) of 2008 altered the oil price–inflation relationship. We further extend our analysis to capture asymmetries using the non-linear autoregressive distributed lag model. Lastly, we use the Campbell and Thompson (2008) forecast evaluation test to comparatively assess the predictive ability of the symmetric (restricted) and asymmetric (unrestricted) models.

Findings
Our results show that asymmetries matter in the oil price–inflation nexus. Also, the effect of the GFC of 2008 is stronger for the developed countries in the short run, and the developing countries in the long run. Lastly, accounting for asymmetries in oil price yields a better forecast for inflation in both groups.

Originality/value
The paper adds some interesting innovations to the oil price–inflation relationship in the OECD countries. It is the study with the widest scope for such country group under two classifications of developed and developing countries. It also inculcates the role of asymmetries, financial crisis, as well as the predictive ability of oil price on inflation.
Environmental scanning, supply chain integration, responsiveness, and operational performance
Authors: Yu Wantao , Chavez Roberto , Jacobs Mark , Wong Chee Yew , Yuan Chunlin 
Published: August 2019

PurposeIt remains unclear how environmental scanning (ES) can generate firm performance through supply chain management (SCM) practices. The purpose of this paper is to investigate the effects of ES on operational performance through supply chain integration (SCI) and supply chain responsiveness (SCR).Design/methodology/approachThe scanning–interpretation–action–performance (SIAP) model and organization information processing theory (OIPT) are used to explain the ES–SCI–SCR–performance (S–I–A–P) relationships, which were tested by structural equation modeling of survey data of 329 manufacturing firms in China.FindingsThe results indicate that ES has a significant positive effect on SCI and SCR. SCI is significantly and positively related to SCR. SCR partially mediates the relationship between ES and operational performance, and fully mediates the relationship between SCI and operational performance.Practical implicationsSupply chain managers should collaborate with senior executives to obtain signals from ES activities, as input for building SCI and SCR and use SCI as a joint interpretation mechanism of ES signals for developing SCR to reap operational advantages in the rapidly changing business environment.Originality/valueStrategic management academics and practitioners have explicitly emphasized the importance of ES in developing strategic plans but are unsure about the role of SCM in creating operational advantages through ES. Using the SIAP model, this study theorizes and demonstrates how SCI and SCR transform signals from ES into operational performance. In doing so, a more precise application of OIPT is explicated in the supply chain context.
Tacit knowledge transfer and spillover learning in ramp-ups
Authors: Letmathe Peter , Rößler Marc 
Published: August 2019

PurposeWith shortening product life cycles and an increasing number of product variants, manufacturing firms perform more production ramp-ups. In this context, learning is crucially important to quickly achieve high production process quality and stability. The paper aims to discuss this issue.Design/methodology/approachThrough a laboratory experiment, this study analyzes spillover learning between consecutive ramp-ups and how this phenomenon is influenced by tacit knowledge transfer through observation and imitation.FindingsThe results prove the existence of spillover learning between consecutive ramp-ups. Moreover, they provide evidence how tacit knowledge transfer through observation and imitation enhances learning of new tasks in consecutive production ramp-ups.Research limitations/implicationsFuture research could focus on the specific psychological processes driving tacit knowledge transfer and spillover learning, a topic which is only touched upon in this paper.Practical implicationsThe findings show that manufacturing firms should not only aim at reaching a steep learning curve during a single production ramp-up, but should also take into account the effects of spillover learning with regard to future production ramp-ups. Furthermore, the paper provides novel insights concerning the allocation of workers to production tasks with regard to previous experience when introducing new personnel and during ramp-up phases.Originality/valuePrevious evidence on the existence and characteristics of spillover learning in production ramp-up situations is not conclusive. This paper provides new and unambiguous insights by considering different organizational settings.
Human capital inequality and economic growth: evidence with sub-national data from Thailand
Authors: Uddin Md Nasir , Sarntisart Saran 
Published: August 2019

PurposeThe purpose of this paper is to find the effects of human capital inequality on economic growth.Design/methodology/approachThailand Labor Force Survey has been used to generate provincial average years of schooling and Gini coefficient of years of schooling for the years 1995‒2012. Econometric techniques have been employed to identify the effects of human capital inequality on economic growth.FindingsEconomic growth is inversely affected by the distribution of human capital in Thailand. The coefficient of human capital inequality suggests that if Gini coefficient increases by 0.01 points, gross provincial product (GPP) decreases by about 2 percentage points in the long run. However, the effect of average years of schooling in GPP is not significant.Research limitations/implicationsThere is a lack of strong theoretical background for the relationship between human capital inequality and economic growth to support the empirical study.Practical implicationsThe findings of the study help to design and evaluate education policies in developing countries like Thailand and other low- and middle-income countries.Originality/valueThis paper is among the first attempts to analyze the effect of human capital inequality on economic growth with sub-national level annual data. In addition, it considers cross sectional dependence in panel model.
Job uncertainty and leaving the parental home in Italy
Authors: Bertolini Sonia , Goglio Valentina 
Published: August 2019

PurposeThe purpose of this paper is to analyse whether and to what extent the labour market situation of young Italians affects their chances of exiting the parental home, differentiating between leaving parental home with or without a partner. The paper also considers whether contextual factors, such as the occurrence of the economic crisis and family-related characteristics, might play a moderating role. The main focus is to understand if new modes of becoming adult are emerging in a country in which leaving home occurs relatively late and where family ties are at the same time a source of protection and a source of reproduction of inequalities.Design/methodology/approachThe paper uses longitudinal data from European Union Statistics on Income and Living Conditions for the period 2007–2014 and applies Event History Analysis techniques for discrete time data. The analyses estimate the hazard rate of leaving the parental home for a sample of Italian individuals in the age range of 16–40 who, at the beginning of the observation period, were living with their parents.FindingsThe empirical analyses highlight a negative association between exclusion from the labour market and housing autonomy, robust and consistent across gender and across types of transition. On the contrary, a situation of objective job insecurity does not emerge as being associated to lower chances of housing autonomy, compared to individuals with job stability. Moreover, the educational background of the family of origin does not show any mediating role on the relative disadvantage of unemployed and inactive individuals, while the relative disadvantage of inactive individuals tends to further worsen in the period after the economic crisis (2010–2014).Originality/valueThe paper contributes to the study of transitions to housing autonomy by differentiating between two modes: in couple or alone. Moreover, by introducing information on the educational background of parents and the time effect, the paper aims to combine different traditions of research coming from the sociology of work, family and inequalities.
How students’ friendship network affects their GPA ranking
Authors: Li Yongli , Li Sihan , Wei Chuang , Liu Jiaming 
Published: August 2019

PurposeDue to the unintentional or even the intentional mistakes arising from a survey, the purpose of this paper is to present a data-driven method for detecting students’ friendship network based on their daily behaviour data. Based on the detected friendship network, this paper further aims to explore how the considered network effects (i.e. friend numbers (FNs), structural holes (SHs) and friendship homophily) influence students’ GPA ranking.Design/methodology/approachThe authors collected the campus smart card data of 8,917 sophomores registered in one Chinese university during one academic year, uncovered the inner relationship between the daily behaviour data with the friendship to infer the friendship network among students, and further adopted the ordered probit regression model to test the relationship between network effects with GPA rankings by controlling several influencing variables.FindingsThe data-driven approach of detecting friendship network is demonstrated to be useful and the empirical analysis illustrates that the relationship between GPA ranking andFNpresents an inverted “U-shape”, richness inSHspositively affects GPA ranking, and making more friends within the same department will benefit promoting GPA ranking.Originality/valueThe proposed approach can be regarded as a new information technology for detecting friendship network from the real behaviour data, which is potential to be widely used in many scopes. Moreover, the findings from the designed empirical analysis also shed light on how to improve GPA rankings from the angle of network effect and further guide how many friends should be made in order to achieve the highest GPA level, which contributes to the existing literature.
Second-hand fashion market: consumer role in circular economy
Authors: Machado Maria Amália Dutra , Almeida Stefânia Ordovás de , Bollick Laura Chiattone , Bragagnolo Gabriela 
Published: August 2019

Purpose
The purpose of this paper is to investigate the role of consumer motivation in the context of the circular economy (CE) through the reuse of fashion products.

Design/methodology/approach
A qualitative approach was employed through ethnographic as well as in-depth interviews with nine consumers who buy used fashion products in thrift stores and street fairs in Brazil.

Findings
The findings are based on interrelationships and overlaps found in the integration between the three-dimensional consumer motivations to buy second-hand fashion cited in the literature. A framework showing a virtuous circle of motivations involving the consumer in an active role in the CE is proposed as a result.

Research limitations/implications
Limitations include participants’ selection and a single region data collection. Implications aim to help researchers to more fully understand a new and complex consumer behavior in a CE.

Practical implications
By highlighting consumers’ motivations for this kind of commerce, the practical implications of this work are the possibilities to inspire retailers to start second-hand fashion businesses. Also, policy makers can focus on engaging consumers in active roles that foster CE events.

Originality/value
This work is one of the first attempts to show the role of consumers in the CE and their motivations to engage in this active behavior.