bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL‐60 cancer cell xenograft growth in vivo
Authors: Hsiao Yin‐Chen , Peng Shu‐Fen , Lai Kuang‐Chi , Liao Ching‐Lung , Huang Yi‐Ping , Lin Chin‐Chung , Lin Meng‐Liang , Liu Kuo‐Ching , Tsai Chin‐Chuan , Ma Yi‐Shih , Chung Jing‐Gung 
Published: January 2019

AbstractGenistein, a major isoflavone compound in soybeans, has been shown to have biological activities including anti‐cancer activates. In the present, we investigated the anti‐leukemia activity of genistein on HL‐60 cells in vitro. The percentage of viable cell, cell cycle distribution, apoptotic cell death, reactive oxygen species (ROS), and Ca2+ production and the level of ΔΨm were measured by flow cytometric assay. Cell apoptosis and endoplasmic reticulum (ER) stress associated protein expressions were examined by Western blotting assay. Calpain 1, GRP78, and GADD153 expression were measured by confocal laser microscopy. Results indicated that genistein‐induced cell morphological changes, decreased the total viable cells, induced G2/M phase arrest and DNA damage and fragmentation (cell apoptosis) in HL‐60 cells. Genistein promoted ROS and Ca2+ productions and decreased the level of ΔΨm in HL‐60 cells. Western blotting assay demonstrated that genistein increased ER stress‐associated protein expression such as IRE‐1α, Calpain 1, GRP78, GADD153, caspase‐7, caspase‐4, and ATF‐6α at 20‐50 μM treatment and increased apoptosis associated protein expression such as pro‐apoptotic protein Bax, PARP‐cleavage, caspase‐9, and ‐3, but decreased anti‐apoptotic protein such as Bcl‐2 and Bid in HL‐60 cells. Calpain 1, GRP78, and GADD153 were increased in HL‐60 cells after exposure to 40 μM of genistein. In animal xenografted model, mice were intraperitoneally injected with genistein (0, 0.2, and 0.4 mg/kg) for 28 days and the body weight and tumor volume were recorded. Results showed that genistein did not affect the body weights but significantly reduced the tumor weight in 0.4 mg/kg genistein‐treated group. Genistein also increased the expressions of ATF‐6α, GRP78, Bax, Bad, and Bak in tumor. In conclusion, genistein decreased cell number through G2/M phase arrest and the induction of cell apoptosis through ER stress‐ and mitochondria‐dependent pathways in HL‐60 cells and suppressed tumor properties in vivo.
Coronarin D induces human oral cancer cell apoptosis though upregulate JNK1/2 signaling pathway
Authors: Liu Yen‐Tze , Hsieh Ming‐Ju , Lin Jen‐Tsun , Chen Gene , Lin Chia‐Chieh , Lo Yu‐Sheng , Chuang Yi‐Ching , Hsi Yi‐Ting , Chen Mu‐Kuan , Chou Ming‐Chih 
Published: January 2019

AbstractThe incidence of oral cancer is increasing all over the world, with rates particularly high in Southeast Asian countries, such as Taiwan. Coronarin D (CD) has been confirmed to have anti‐inflammatory, anti‐bacterial effects, and anti‐apoptotic effects in human hepatocellular carcinoma and nasopharyngeal carcinoma. The purpose of this study is to explore whether CD has a suppression effect on oral cancer cells and the mechanisms involved. The results of our study revealed the significantly decreased cancer cell viability and increased activation of apoptosis via increased loss of mitochondrial membrane potential, increased death receptors, leading to the activation of caspase‐8, ‐9, ‐3. Moreover, the rate of apoptosis of cells treated with CD plus JNK inhibitors was decreased compared to CD‐treated cells. This is the first study to demonstrate that CD induces apoptosis in human oral cancer cells and can be expected to be a promising anticancer agent for oral cancer treatment.
Uptake of Pb(II) onto nanochitosan/sodium alginate hybrid beads: Mechanism and kinetics study
Authors: Ablouh El‐houssaine , Essaghraoui Abderrazzaq , Eladlani Nadia , Rhazi Mohammed , Taourirte Moha 
Published: January 2019

AbstractNanochitosan/sodium alginate (NCS/SA) beads were prepared using nanochitosan and alginate as a high‐performance absorbent for Pb(II) removal from aqueous solution. The morphology, structure, thermal stability, surface area, and elements present in the NCS/SA beads before and after adsorption were characterized using instrumental techniques like SEM, FTIR, TGA, BET, and EDX analysis, respectively. Various adsorption parameters were studied. The results indicated that the equilibrium adsorption data were fitted to Langmuir isotherms and the maximum Langmuir monolayer capacity of Pb(II) was 178.57 mg/g at 45°C. The adsorption process was in good agreement with pseudo‐first‐order kinetic model. Mechanism studies showed that electrostatic interaction and ion exchange were the major mechanisms for lead (II) removal by the NCS/SA beads. The results of this study indicate that NCS/SA beads could be used as an effective adsorbent for the elimination of lead (II) present in aqueous solution.Practitioner points

Nanochitosan/sodium alginate beads were synthesized using Ca2+ as a crosslinking agent.

NCS/SA beads were used to remove Pb(II) for the first time and working parameters were optimized.

Adsorption monolayer capacity of NCS/SA adsorbent towards Pb (II) was found to be 178.57 mg/g.
Authoritarianism, trauma, and insecure bonds during the Greek economic crisis
Authors: Sochos Antigonos 
Published: January 2019

AbstractThis correlational study investigated the link between authoritarian attitudes, psychosocial trauma, and attachment insecurity in the context of a significant community and personal threat – the recent economic crisis in Greece. The study utilised a large community sample and five self-report measures - Right-Wing Authoritarianism Scale-S, Social Group Attachment Scale, Relationship Questionnaire, Perceived Cohesion Scale, and Impact of Events Scale-R. It was hypothesised that authoritarianism would be independently linked with insecurity in two types of bond (person-to-person and person-to-state) via the experience of post-traumatic stress and perceptions of social cohesion. Structural Equation Modelling indices suggested that the model had a very good fit.
Democratic or cultural peace? Examining the joint democratic peace proposition through the lens of shared emancipative values
Authors: Omelicheva Mariya , Carter Brittnee 
Published: January 2019

AbstractIs it joint democracy or state similarity that has a pacifying impact on interstate relations? This study explores the complementarity of the two propositions and demonstrates the potential of a particular kind of shared emancipative culture embracing values of autonomy, equality, choice, and voice to amplify the impact of joint democracy on interstate conflict. The data on cultural values, which comes from the World Values Survey, was integrated with the data from the Correlates of War Project to test the impact of joint democracy and cultural similarity on militarised interstate disputes (1981–2010). We find that culturally similar dyads are less likely to be involved in conflict with each other than culturally dissimilar dyads. Although, cultural similarity does not wash out the pacifying effect of democracy, it offers a complementary explanation to the democratic peace. We also find that states that are democratic and share higher than average scores on the emancipative values are less likely to engage in militarised interstate disputes than democratic states, which are culturally dissimilar or score low on the emancipative dimensions. This provides support for an additional normative/cultural impact on democratic peace.
Effects of offering grass silage alone or in combination with lupin/triticale, lupin/wheat or pea/oat whole-crop silages on animal performance, meat quality and fatty acid composition of beef from cattle offered two levels of concentrate
Authors: Kennedy P. C. , Dawson L. E. R. , Lively F. O. , Steen R. W. J. , Fearon A. M. , Moss B. W. , Kilpatrick D. J. 
Published: January 2019

AbstractAn experiment was carried out to examine the effects of offering beef cattle five silage diets. These were perennial ryegrass silage (PRGS) as the sole forage, tall fescue/perennial ryegrass silage (FGS) as the sole forage, PRGS in a 50:50 ratio on a dry matter (DM) basis with lupin/triticale silage (LTS), lupin/wheat silage (LWS) and pea/oat silage (POS). Each of the five silage diets was supplemented with 4 and 7 kg of concentrates/head/day in a five silages × two concentrate intakes factorial design. A total of 90 cattle were used in the 121-day experiment. The grass silages were of medium digestibility and were well preserved. The legume/cereal silages had high ammonia N, high acetic acid, low lactic acid, low butyric acid and low digestible organic matter concentrations (542, 562 and 502 g/kg DM for LTS, LWS and POS, respectively). Silage treatment did not significantly affect liveweight gain, carcass gain, carcass characteristics, the instrumental assessment of meat quality or fatty acid composition of theM. longissimus dorsimuscle. In view of the low yields of the legume/cereal crops, it is concluded that the inclusion of spring-sown legume/cereal silages in the diets of beef cattle is unlikely to be advantageous.
Long-term care preference among Japanese older adults: differences by age, period and cohort
Authors: Sugisawa Hidehiro , Sugihara Yoko , Nakatani Yomei 
Published: January 2019

AbstractThis study examined the differences in the preference for long-term care (LTC) by age, period and cohort (A-P-C) in Japanese older adults through repeated cross-sectional surveys from 1998 – before the establishment of LTC insurance – to 2016, in a suburban city of metropolitan Tokyo. We analysed the direct effects of A-P-C on the preference for LTC, as well as the interaction effects of A-P-C on preference by gender, family structure and activities of daily living. Data were obtained at six time-points using repeated cross-sectional surveys for people aged 65 and older; surveys were conducted in 1998, 2002, 2004, 2010, 2013 and 2016. The preference for LTC was composed of three categories: informal care, community LTC services (CLTCS) and institutional LTC services (ILTCS). The cross-classified random-effect model was used to specify A-P-C effects. Informal care, CLITCS, ILTCS and other/no answer composed 35, 23, 33 and 9 per cent of preferences, respectively. In terms of the period effect, while there was an increase in levels of preference for CLTC between 1998 and 2010 as compared to informal care, the levels of preference were almost identical after 2010. In terms of the age effect, younger participants were more likely to prefer CLTCS and ILTCS over informal care. Moreover, the age influence was stronger in females and respondents who lived alone. We did not observe a cohort effect for preference. This study suggests that there are gaps by period and age between the preference for LTC services and the actual LTC use in Japanese older adults, and as a result, the use of actual LTC services cannot fully reflect the intentions and preference for LTC in them.
Perceptions of home in long-term care settings: before and after institutional relocation
Authors: Wada Mineko , Canham Sarah L. , Battersby Lupin , Sixsmith Judith , Woolrych Ryan , Fang Mei Lan , Sixsmith Andrew 
Published: January 2019

AbstractAlthough moving from institutional to home-like long-term care (LTC) settings can promote and sustain the health and wellbeing of older adults, there has been little research examining how home is perceived by older adults when moving between care settings. A qualitative study was conducted over a two-year period during the relocation of residents and staff from an institutional LTC home to a purpose-built LTC home in Western Canada. The study explored perceptions of home amongst residents, family members and staff. Accordingly, 210 semi-structured interviews were conducted at five time-points with 35 residents, 23 family members and 81 staff. Thematic analyses generated four superordinate themes that are suggestive of how to create and enhance a sense of home in LTC settings: (a) physical environment features; (b) privacy and personalisation; (c) autonomy, choice and flexibility; and (d) connectedness and togetherness. The findings reveal that the physical environment features are foundational for the emergence of social and personal meanings associated with a sense of home, and highlight the impact of care practices on the sense of home when the workplace becomes a home. In addition, tension that arises between providing care and creating a home-like environment in LTC settings is discussed.
Mapping out particle placement in Englishes around the world: A study in comparative sociolinguistic analysis
Authors: Grafmiller Jason , Szmrecsanyi Benedikt 
Published: January 2019

AbstractThis study explores variability in particle placement across nine varieties of English around the globe, utilizing data from the International Corpus of English and the Global Corpus of Web-based English. We introduce a quantitative approach for comparative sociolinguistics that integrates linguistic distance metrics and predictive modeling, and use these methods to examine the development of regional patterns in grammatical constraints on particle placement in World Englishes. We find a high degree of uniformity among the conditioning factors influencing particle placement in native varieties (e.g., British, Canadian, and New Zealand English), while English as a second language varieties (e.g., Indian and Singaporean English) exhibit a high degree of dissimilarity with the native varieties and with each other. We attribute the greater heterogeneity among second language varieties to the interaction between general L2 acquisition processes and the varying sociolinguistic contexts of the individual regions. We argue that the similarities in constraint effects represent compelling evidence for the existence of a shared variable grammar and variation among grammatical systems is more appropriately analyzed and interpreted as a continuum rather than multiple distinct grammars.
Air design, meteorological architecture, and atmospheric preservation: towards a theory of feeling
Authors: Corbo Stefano 
Published: January 2019

In 1960, Belgian artist Rene Magritte painted La Corde Sensible. In the background is a natural landscape, characterised by mountains and by a river. At the front is a champagne glass topped by a cloud. It prompts questions: does the cloud have its own weight? Is the glass mediating between the liquid state of the river and the gaseous state of the cloud? A few years later in 1972, the Viennese group Haus-Rucker-Co depicted a similar provocative scenario in ‘Big Piano’. In place of a champagne glass, a ladder with many steps – each with a different sound – reaches towards a cloud, which is a site of immersion and the loss of orientation.These two examples, along with other artistic manifestations from the same period, reveal the rise of an aesthetic sensibility, which for the first time, questioned traditional physical and perceptual boundaries seemingly fixed by tradition, pursuing a sort of material evanescence. They illustrate a process of formal and conceptual dematerialisation. Generally, one may say that, from the second half of the twentieth century, the discipline of aesthetics experienced a radical change: shifting away from semantic or hermeneutic interpretations back to its original meaning: aesthetics as aisthesis, the ancient Greek word for perception. This implied a rediscovery of the body, the rehabilitation of the senses, and a renewed interest in phenomenology.
An Improved Method to Shorten Physiological Dormancy of Giant Ragweed (Ambrosia trifida) Seed
Authors: Harre Nick T. , Weller Stephen C. , Young Bryan G. 
Published: January 2019

AbstractTimely results from whole-plant, herbicide-resistant weed screenings are crucial to heighten grower awareness. However, the high degree of physiological dormancy of giant ragweed (Ambrosia trifidaL.) seed exacerbates this process. The most effective methods for alleviating dormancy, to date, are either labor-intensive (embryo excision) or require several weeks (soil stratification). This research describes a conditioning process involving clipping and aeration of seed in water that is highly effective at alleviating dormancy and requires less skill and time compared with previous techniques.Ambrosia trifidaseeds were collected over 2 yr at two different collection timings (September 25, “early”; October 25, “late”), subjected to various treatments intended to release dormancy, and evaluated for emergence over 18 d in the greenhouse. The use of germination-promoting chemicals (ethephon, gibberellic acid, and thiourea) generally provided no increase in emergence compared with water and occasionally produced seedlings with abnormal growth unsuitable for further experimentation. Conditioning yielded between 30% and 33% emergence for both early and late collections of seeds with no afterripening period compared with 0% emergence for seeds imbibed in water. Following an 8-wk period of dry storage at 4 C, conditioning yielded nearly 80% emergence for both collection timings, while emergence of seeds imbibed in water was 10% and 27% for early and late collections, respectively. Soil stratification in moist soil for 8 wk at 4 C was the second most effective treatment, yielding 46% to 49% emergence across both collections. Parameters of the Weibull function further indicated the conditioning treatment had the fastest rate of emergence and shortest lag phase between planting and first emergence. Methods to germinateA. trifidawithout an afterripening period have previously been unsuccessful. Therefore, the seed-conditioning method outlined in this work will be useful in expediting the confirmation of herbicide-resistantA. trifidaincidences.
Induced Polarization of Rocks Containing Metallic Particles: Evidence of Passivation Effect
Authors: Gurin Grigory , Titov Konstantin , Ilyin Yuri 
Published: January 2019

AbstractWe studied the impact of electrical isolation (passivation) of metallic particles on induced polarization (IP) parameters. We carried out laboratory experiments with six synthetic models made of sieved sand mixed with metallic particles. The purpose of this experiment was to understand what mechanism (polarization of positive and negative charge carriers within the particles or interfacial polarization) was responsible for the IP effect. Size and location of passivated zones on the particle surfaces varied from model to model. We observed a decrease of the total chargeability and relaxation time values with the increase of passivated surface. Fully passivated metallic particles showed no IP effect. These data suggest the dominant role of the interface phenomena in IP associated with metallic particles.
Millennial‐Scale Vulnerability of the Antarctic Ice Sheet to Regional Ice Shelf Collapse
Authors: Martin Daniel F. , Cornford Stephen L. , Payne Antony J. 
Published: January 2019

AbstractThe Antarctic Ice Sheet (AIS) remains the largest uncertainty in projections of future sea level rise. A likely climate‐driven vulnerability of the AIS is thinning of floating ice shelves resulting from surface‐melt‐driven hydrofracture or incursion of relatively warm water into subshelf ocean cavities. The resulting melting, weakening, and potential ice shelf collapse reduces shelf buttressing effects. Upstream ice flow accelerates, causing thinning, grounding‐line retreat, and potential ice sheet collapse. While high‐resolution projections have been performed for localized Antarctic regions, full‐continent simulations have typically been limited to low‐resolution models. Here we quantify the vulnerability of the entire present‐day AIS to regional ice shelf collapse on millennial timescales treating relevant ice flow dynamics at the necessary ∼1‐km resolution. Collapse of any of the ice shelves dynamically connected to the West Antarctic Ice Sheet (WAIS) is sufficient to trigger ice sheet collapse in marine‐grounded portions of the WAIS. Vulnerability elsewhere appears limited to localized responses.
Robust Estimation of Rupture Properties at Propagating Front of Laboratory Earthquakes
Authors: Xu Shiqing , Fukuyama Eiichi , Yamashita Futoshi 
Published: January 2019

AbstractEarthquake rupture propagation along a fault interface depends on the governing friction law. Although a variety of friction laws have been proposed based on measurements made in the lab, uncertainty remains regarding to what extent those measurements capture the true rupture properties. By comparing laboratory earthquakes with numerically simulated ruptures, we find that certain properties inside the rupture front may not always be accessible to direct measurements in the real world, due to a lack of resolution caused by the shrinking size of rupture front zone (Lorentz contraction). Instead, we propose an indirect method to robustly estimate rupture properties of laboratory earthquakes, by simultaneously fitting both the trajectory of rupture front and the detailed strain waveform shape using numerical synthetics. Under the current data resolution and on the basis of a slip‐weakening friction model, our method can provide upper bound constraints on slip‐weakening distance, in addition to regular constraints on fracture energy. Application of this new method to 26 laboratory earthquakes shows that rupture properties (directivity, propagation speed, fracture energy, and frictional strength) can fluctuate over earthquake cycles. Post hoc examination further suggests that our direct measurements largely reflect the deformation features outside the rupture front. As the same issue on the feasibility of direct measurements inside the rupture front may exist in other studies, our work questions the accuracy of previously derived friction laws, addresses the need for calibrating measurement location and resolution, and provides a means for examining the self‐consistency of estimated rupture properties.
Land Surface Processes Create Patterns in Atmospheric Residence Time of Water
Authors: Tuinenburg O. A. , van der Ent R. J. 
Published: January 2019

AbstractRecent studies determined the residence time of moisture in the atmosphere to be 8–10 days but with large spatial and temporal differences. An unexplained daily cycle in the probability density function (PDF) of the residence time of land evaporation was observed, which was not present for oceanic evaporation. Moreover, the PDF of atmospheric residence time of oceanic evaporation was found to be a monotonically decreasing, while for land evaporation, this function had increasing probabilities during the first few days and monotonically decreasing probabilities thereafter. This research determines the causes of (I) the daily cycle in this PDF and (II) the shape of the atmospheric residence time PDF. The strong daily cycle in the residence time PDF using ERA‐Interim is attributed to the fact that the evaporation and precipitation have the same diurnal cycle in ERA‐Interim. Therefore, evaporation entering the atmosphere has the highest probability of returning to the land surface as precipitation at the same moment during the day but possibly a number of days later. Interestingly, this diurnal cycle was almost absent in the simulations forced with GLDAS surface fluxes. Therefore, we conclude that the previously found daily cycle in the atmospheric residence time PDF is due to differences in the diurnal cycles of precipitation in the underlying data sets. Transpiration causes the increasing probabilities during the first days, while bare soil evaporation and canopy interception typically have a monotonically decreasing PDF. Therefore, we conclude that transpiration causes the largest differences in atmospheric residence time between ocean and land evaporation.