bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of Alpha-Gal IgE Sensitization in 3000 Military Personnel, Assessing Sex, Race, Installation, and Occupational Impacts
Authors: Ching Susan J. , Susi Apryl , Ailsworth Samuel M. , Workman Lisa J. , Platts-Mills Thomas A. E. , Wilson Jeffrey M. , Nylund Cade M. 
Published: November 2024

Background/Objectives: IgE to galactose-alpha-1,3-galactose (alpha-gal) is associated with Amblyomma americanum (lone star tick) bites, accounting for the regional distribution of the alpha-gal syndrome (AGS). Longitudinal studies describing risk factors for incident alpha-gal sensitization are lacking. The objective of this project was to assess the incidence of alpha-gal IgE seroconversion and identify associated demographic, occupational, and geographical risk factors among US military personnel. Methods: Samples from the Department of Defense Serum Repository were evaluated at two time points at least 3 years apart. In total, 3000 service members stationed at 10 military installations within the A. americanum tick range were included. Installation, sex, race and ethnicity, rank, military occupation, and branch of service were evaluated. Alpha-gal IgE seroconversion was defined as a change from <0.1 kU/L) to ≥0.1 kU/L. Results: Among the 2821 personnel who were alpha-gal IgE-negative at baseline, 138 (4.9%) seroconverted over a mean interval of 3.4 years. Seroconversion was more frequent in males (5.5% vs. 1.9%), White individuals (6.6% vs. 1.0% in Black people and 1.5% in Hispanics), and individuals in occupations with higher presumed outdoor exposure (e.g., infantry/law enforcement: 12.7% vs. administrative: 1.2%). Differences were not significant between sexes when accounting for military installation/occupation, but differences in race and ethnicity remained significant. Conclusions: This study demonstrates that alpha-gal IgE seroconversion is occurring within the A. americanum tick range and is associated with White race and ethnicity, and occupations with higher outdoor exposure. Further research is needed to elucidate the influence of race and ethnicity on alpha-gal sensitization and develop effective prevention and treatment strategies for AGS.
Inhalation corticosteroids for COVID-19 – a real world data analysis on guideline adherence
Authors: van Egeraat Jasper WA , Kuijpers Ton , Burgers Jako , van Os Hendrikus , Chavannes Niels H , Bonten Tobias N 
Published: November 2024

BackgroundThe recommendation to consider prescribing inhalation corticosteroids to a subgroup of vulnerable COVID-19 patients was added to the Dutch medical guideline on November 11, 2021, and was also adopted by other countries during the pandemic.AimTo evaluate the adherence of general practitioners to this guideline, and whether real-world data quality is sufficient to study the effect of revised guidelines on prescribing behaviour.Design & settingA retrospective cohort study using Dutch primary care data from the Extramural LUMC Academic Network database, containing patient data of 129 general practices in the Leiden – The Hague area.MethodWe performed an interrupted time series analysis to measure the effect of the new guideline on the prescription rate of ICS, accounting for general trend and seasonal fluctuations.ResultsBetween July 1, 2020 to August 1, 2022, 131,482 patients had 164,098 COVID-19 consultations. During this period, 1,709 patients received 2094 ICS prescriptions for COVID-19. After the guideline update, there was an instantaneous decrease in prescription rate (IRR 0.47, 95% CI 0.32-0.69). Prescription rate in the subgroup of vulnerable patients did not change significantly (IRR 0.93, 95% CI 0.66-1.32), while less vulnerable patients were significantly prescribed less (IRR 0.29, 95% CI 0.14-0.59).ConclusionThe revision to COVID-19 guidelines had significant impact on general practitioners’ prescription behaviour soon after publication: prescription rate remained constant for vulnerable patients, while less vulnerable patient were significantly prescribed less often. Using electronic health records it is feasible to assess changes in guideline adherence using interrupted time series.
Higher Serum Alkaline Phosphatase is Risk for Death and Fracture
Authors: Maruyama Yukio , Nakashima Akio , Abe Masanori , Hanafusa Norio , Nakai Shigeru , Yokoo Takashi 
Published: November 2024

Background:
Monitoring of serum alkaline phosphatase (ALP) is recommended in the management of chronic kidney disease (CKD)-mineral bone disorder (MBD) because of associations with poor outcome among dialysis patients. However, such associations may have changed with several advances in the management of CKD-MBD over the last decade.

Methods:
Baseline data for 241,670 dialysis patients (mean age, 69 ± 12 years; male, 65.9%; median dialysis duration, 68 months) were extracted from a nationwide dialysis registry in Japan at the end of 2019. Outcomes, including all-cause and cardiovascular (CV) mortality and hip fracture, were evaluated using the registry at the end of 2020 and 2021. All-cause mortality was assessed using Cox regression analysis, whereas CV mortality and new hip fracture were assessed using competing-risks regression analysis. Multiple imputation for missing values was performed.

Results:
Within the 2-year study period, a total of 40,449 patients (16.7%) died, including 13,562 (5.6%) CV deaths. Of the 168,836 patients with no history of hip fracture at the end of 2019, 4,136 (2.4%) suffered hip fracture within 2 years. Higher serum ALP was independently associated with higher all-cause and CV mortality and new hip fracture, but the association with CV mortality was marginal (hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.18-1.24; sub-HR [SHR] 1.07, 95%CI 1.03-1.12; and SHR 1.28, 95%CI 1.19-1.38, respectively). There is a linier association between serum ALP and all-cause mortality among the lower- parathyroid hormone (PTH) group, whereas lower serum ALP tended to have higher all-cause mortality than intermediate serum ALP among patients in the higher-PTH group.

Conclusions:
Higher serum ALP was independently and linearly associated with higher all-cause and CV mortality and new hip fracture in Japanese dialysis patients. Higher serum ALP and higher intact PTH were synergistic in increasing all-cause and CV mortality but not with new hip fracture.
Диффузия информационно-коммуникационных технологий в странах БРИКС
Authors: М.Г. Дубинина 
Published: November 2024

В статье рассмотрены проблемы развития сектора ИКТ стран БРИКС на современном этапе, проанализирован уровень распространения цифровых технологий и место, занимаемое странами в мировых рейтингах информационного общества. Проанализирована динамика торговли ИКТ-товарами и услугами. Оценена диффузия интернета для этих стран с помощью логистической модели и модели Басса. Для выявления макроэкономических факторов, влияющих на скорость распространения интернета, построена пространственно-временная модель его диффузии по странам БРИКС.
The article examines the problems of development of the ICT sector of the BRICS countries at the present stage, analyzes the level of distribution of digital technologies and the place occupied by countries in world rankings of the information society. The dynamics of trade in ICT goods and services are analyzed. Internet diffusion for these countries was estimated using the logistic model and the Bass model. To identify macroeconomic factors influencing the speed of Internet diffusion, a space-time model of its diffusion across the BRICS countries was built. Keywords: digital technologies, information and communication technologies, ICT infrastructure, space-time model, Internet, digital development index
Демографические характеристики занятости в области информации и связи, в финансах и страховании в России
Authors: А.М. Нанавян 
Published: November 2024

В работе проанализированы демографические аспекты занятости в сфере информации и связи и в финансах и страховании. В этих видах деятельности наименьшее значение среднего возраста занятых в России, но наблюдается рост значения этого показателя, особенно в финансах и страховании. Это связано как с сокращением численности лиц в возрасте 20–29 лет, так и с увеличением численности старших возрастных групп в составе занятых в рассматриваемых видах экономической деятельности.
The paper analyzes the demographic aspects of employment in the field of information and communications and in finance and insurance. In these types of activities, the average age of the employed in Russia is the lowest, but there is an increase in the value of this indicator, especially in finance and insurance. This is due both to a decrease in the number of people aged 20-29 years, and to an increase in the number of older age groups employed in the types of economic activities under consideration.
Victorine Meurent, modèle et artiste. Relecture d’un mythe de la décadence artistique
Authors: Dollet Adeline 
Published: November 2024

Adolphe Tabarant, journaliste et critique d’art, a publié en 1931 et 1947 deux ouvrages qui constituent une source de premier ordre dans l’étude de l’œuvre et de la vie du peintre Édouard Manet. En 2023, la Morgan Library and Museum de New York a acquis une photocopie d’un manuscrit inédit et non publié de Tabarant. Ce manuscrit intitulé « Celle qui fut l’Olympia de Manet » se présente comme un récit biographie de Victorine Meurent, modèle préféré de Manet pour qui elle a posé entre 1862 et 1872. En rapport avec le mémoire de master consacrée à Meurent, l’objectif de cet article est d’évaluer certains éléments du manuscrit qui permettent d’établir sa valeur historique dans l’élaboration du mythe du modèle décadent, associé à la figure de Meurent.
The time factor and the allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia
Authors: Parovichnikova E. N. , Kuzmina L. A. , Vasilyeva V. A. , Pokrovskaya O. S. , Drokov M. Yu. , Lukyanova I. A. , Fidarova Z. T. , Gaponova T. V. , Troitskaya V. V. 
Published: November 2024

Introduction. The current overall effectiveness of acute myeloid leukemia (AML) treatment is largely ensured by the integration of transplantation technologies, but not all patients who are indicated to undergo transplantation of allogeneic hematopoietic stem cells (allo-HSCT) can reach this stage.Aim: to analyze the time and volume of the implementation of allo-HSCT in patients with AML in the first complete remission (1CR).Materials and methods. Between January 2020 and December 2023, 477 AML patients from 43 different regions of the Russian Federation were referred to the NMRC for Hematology for the possibility of performing allo-HSCT. In this cohort of patients, the following time parameters were analyzed: days from diagnosis of AML to primary treatment at the transplant center, from primary treatment to search for a donor (related or non-related), from diagnosis of AML to allo-HSCT, from the achievement of 1CR to allo-HSCT.Results. 175 (36.7 %) patients, agreed upon by the Transplant Commission, were selected to undergo allo-HSCT. Of these, only 163 patients, who had allo-HSCT performed before January 2024, were included in further analysis. It was not possible to implement allo-HSCT in the other 236 agreed upon cases due to the following reasons: refusal of the patient — 110 (46.6 %), relapse — 48 (20.3 %) patients, death — 23 (9.7 %) patients. Median time from 1CR to allo-HSCT was 6.8 (0.3– 26) months for all patients: for a related fully compatible donor 5.8 (0.5–26.0) months, for a haploid donor — 6.1 (0.3–23.5) months, in case of non-related — 8.0 (0.6–8.6) months. In 5 years, the NMRC for Hematology managed to reduce the time to the general allo-HSCT in 1CR for patients with AML from 6.5 months in 2018 to 5.8 months in 2023. Also, under the current “AML-21” protocol, the time from 1CR to allo-HSCT in patients included in the multicenter study was minimized to — 4.8 (0.33–11.0) months, and for AML patients from the poor prognosis group — 3.4 (0.33–8.0 months).Conclusion. In addition to achieving full, optimally — MDR-negative remission, the absence of severe concomitant pathology, and the presence of a donor, the time factor must also be considered. In order to cure more AML patients, it is necessary to bring the implementation of allo-HSCT to the earliest possible date after achieving 1CR.
Effect of glucocerebrosidase on human bone marrow multipotent mesenchymal stromal
Authors: Mamonov V. E. , Sadovskaya A. V. , Petinati N. A. , Shipounova I. N. , Dorofeeva A. I. , Drize N. I. , Lukina E. A. 
Published: November 2024

Introduction. During enzyme replacement therapy in patients with Gaucher disease (GD) with recombinant glucocerebrosidase (GCase), regression of bone manifestations is possible, but with prolonged therapy osteonecrosis may occur. These changes may be due to impaired differentiation of multipotent mesenchymal stromal cells (MSCs).Aim: to study changes in the MSCs of healthy donors and a patient with GD when cultured in the presence of GCase.Material and methods. MSCs were isolated from the bone marrow of 17 healthy donors and a female patient with GD by a standard method and cultured in the presence of various concentrations of GCase after the second passage from 2 to 7 weeks. Cell proliferation and the ability to differentiate were analyzed, including after induction. The assessment was carried out by differential staining, elution, and expression of differentiation marker genes by real-time PCR.Results. Low concentrations of recombinant GCase (0.25–1.5 U/ml) did not affect the proliferative activity of MSCs. Prolonged cultivation of MSCs in the presence of low doses of GCase led to a change in the differentiation potential of these cells in the direction of adipogenesis. Concentrations of GCase of 3–5 U/ml inhibited the proliferation of MSCs and caused significant changes in cell differentiation. High doses of the enzyme (7–10 U/ml) had a cytotoxic effect and led to cell death within one passage. The proliferative and differentiation potential of the MSCs of a patient with GD differed significantly from the cells of healthy donors in all the parameters studied.Conclusion. The cultivation of donor MSCs in the presence of recombinant GCase alters the proliferation and differentiation potential of these cells. These changes depend on the dose of the enzyme in the medium and the duration of cultivation.
Diakrytyczne cechy eschatologii pentekostalnej
Authors: Ern Agata 
Published: November 2024

Artykuł poświęcony jest eschatologii pentekostalnej, wyróżniającej się na tle tradycyjnych koncepcji eschatologicznych. Pierwsza część artykułu porusza aspekt genezy eschatologii pentekostalnej i to, jak rozumiana jest eschatologia w ewangelikalizmie. Kolejne części pracy traktują o założeniach pentekostalizmu i związanej z nim eschatologii. Postawiono pytania o paruzję i w jaki sposób należy się do niej przygotować w świetle eschatologii pentekostalnej. Eschatologia zielonoświątkowa kładzie akcent na osobę Ducha Świętego jako inspiratora procesu nawrócenia człowieka i jego przygotowania na Boży sąd. Jedynie Duch Święty uzdalnia człowieka, by ten mógł współpracować z Bogiem nad realizacją scenariusza eschatologicznego. Na koniec zostaje postawione pytanie, czy eschatologia została już zrealizowana. Teologia pentekostalna twierdzi, że eschatologia jest proceduralna, a może być zrealizowana jedynie w paruzji.
Dermatite e Doenças Sistêmicas: Relações Clínicas e Diagnóstico Diferencial
Authors: Aparecido Irrazabal Leandro , Moreira Menezes Maria Eduarda , Speth Eichner Nathan , De Carvalho do Nascimento Castro Anna Paulla , Pereira Nicoly , De Moraes Oliveira Dávila , de Souza Silva Barbosa Luiz Philipe , Dos Reis Vial Eduarda , Bordignon Flores Alexandra Maria , De Assis Rocha Lima Felipe , De Medeiros Oliveira Paulo Victor , Lucena Santos Priscylla , Zacarias Queiroz de Barros Braga Guilherme 
Published: November 2024

Introdução: A dermatite é uma condição inflamatória da pele que pode se manifestar através de erupções cutâneas, vermelhidão, coceira e descamação. Embora frequentemente considerada uma condição isolada da pele, pode estar intimamente relacionada a diversas doenças sistêmicas. Portanto, é fundamental adotar uma abordagem abrangente, que considere não apenas os sintomas dermatológicos, mas também o contexto sistêmico do paciente. Objetivo: : Explorar as conexões entre manifestações dermatológicas e condições sistêmicas subjacentes Metodologia: Foram utilizadas as bases de dados Cochrane, Scielo e Pubmed, buscando artigos publicados entre os anos de 2019 e 2024, nos idiomas Português ou Inglês. Considerações Finais: A dermatite está frequentemente relacionada a diversas doenças sistêmicas, por isso, requer uma abordagem clínica abrangente, visando um diagnóstico diferencial adequado. Nesse contexto, é essencial considerar as manifestações cutâneas como possíveis sinais de condições subjacentes, tais como doenças autoimunes, infecciosas, endocrinológicas e hematológicas. Dessa forma, uma gestão eficaz depende da interação entre diagnóstico preciso e estratégias terapêuticas adaptadas a cada caso.
Протестантизм в Японии: несостоявшееся обращение
Authors: Н.А. Мязин 
Published: November 2024

Рассматривается развитие протестантизма в Японии от завершения самоизоляции страны до настоящего времени. Первоначально протестантизм активнее распространялся среди представителей самурайского сословия и образованных слоев населения. В довоенный период синтоизм стал частью государственной идеологии, христианство воспринималось как иностранная религия. После поражения Японии в войне была возвращена свобода вероисповедания. Христиане составляли около 1 % населения Японии, значительно большее распространение получили новые религии, созданные на основе буддизма. В статье уделено внимание взаимодействию христианства с японскими религиозными традициями: буддизмом и синтоизмом. Сделан вывод, что основная причина ограниченного принятия христианства — укорененность населения в буддистской культуре.
The article looks at the development of Protestantism in Japan from the end of the country’s self-isolation to the present day. Initially, Protestantism was more actively spread among representatives of the samurai class and the better educated strata of the population. In the pre-war period, Shintoism became part of the state ideology, and Christianity was perceived as a foreign religion. After Japan’s defeat in the war, freedom of religion was restored. Christians made up about 1 % of Japan’s population, but new religions based on Buddhism became much more widespread. The article focuses on the interaction of Christianity with Japanese religious traditions: Buddhism and Shintoism. It is concluded that the main cause of the limited adoption of Christianity was the population’s rootedness in Buddhist culture.
К творческой истории драматической поэмы С. А. Есенина «Пугачев»: текстология и поэтика ремарок в черновом автографе
Authors: А.А. Николаева 
Published: November 2024

Цель статьи — проанализировать правку С. А. Есенина в черновом автографе драматической поэмы «Пугачев», связанную с работой поэта над ремарками. В есениноведении уже было доказано, что отказ от большей части ремарок, сохранившихся в черновике, обусловлен изменением жанра произведения. Однако исследователями не было отмечено, что поэт, задумывая произведение для постановки на сцене, уделял существенное внимание работе с ремарками. Автор статьи отмечает значительное количество вариантов одной ремарки в черновике (до четырех). Исследователь выделяет несколько типов правки внутри ремарок, связанных с указанием на детали происходящего, на действие героев на сцене и с работой над театральными приемами и эффектами. В результате делается вывод о том, что Есенин много работал не только над монологами и диалогами действующих лиц, но также и над ремарками, планируя использовать их как особые указания постановочной группе.
The purpose of the article is to analyze the editing of S. A. Yesenin in the draft autograph of the dramatic poem Pugachev connected with the poet’s work on stage directions. It has already been proved in Yesenin studies that rejection of most of the remarks preserved in the draft is due to a change in the poem’s genre. However, researchers have not taken into account that the poet, conceiving the work for staging on stage, paid considerable attention to the work with remarks. The author of the article notes a significant number of variants of such directions in the draft (up to four variants). The researcher identifies several types of proofreading options in these directions, pointing out the details of what is happening onstage, the movements of the actors and the theatrical techniques and effects. The conclusion is that Yesenin worked extensively not only on his characters’ monologs and dialog cues, but also on the stage directions and meant to use them as special instructions to a theatrical production team.
John André:
Authors: Ronald D.A.B. 
Published: November 2024

Abstract
At the height of the American Revolutionary War, the British hatched a plot to turn a senior American general, Benedict Arnold. Mastermind of the plot was the Huguenot-born Major John André, Adjutant-General and effective head of Britain’s secret service in North America. The plot was discovered at the eleventh hour. André was captured behind American lines and executed as a spy on 2 October 1780. These events are well-known to students of the war, as are the reactions of Americans at the time. Less well-known are the reactions of the British. This article briefly revisits the events but resets them in the context of Britain’s war propaganda, which, at the time, was seeking how best to represent the nation’s quest for empire and had focused on the image of the ‘young British hero’ as a centrepiece of this campaign. This article explores how André and the events of his life and, especially, his death were seen to encapsulate the new iconography.
A Study on the Nested Rings CME Structure Observed by the WISPR Imager Onboard Parker Solar Probe
Authors: Shaik Shaheda Begum , Linton Mark G. , Gibson Sarah E. , Hess Phillip , Colaninno Robin C. , Stenborg Guillermo , Braga Carlos R. , Palmerio Erika 
Published: November 2024

Abstract
Despite the significance of coronal mass ejections (CMEs) in space weather, a comprehensive understanding of their interior morphology remains a scientific challenge, particularly with the advent of many state-of-the-art solar missions such as Parker Solar Probe (Parker) and Solar Orbiter (SO). In this study, we present an analysis of a complex CME as observed by the Wide-Field Imager for Solar PRobe (WISPR) heliospheric imager during Parker’s seventh solar encounter. The CME morphology does not fully conform with the general three-part density structure, exhibiting a front and core not significantly bright, with a highly structured overall configuration. In particular, its morphology reveals nonconcentric nested rings, which we argue are a signature of the embedded helical magnetic flux rope of the CME. For that, we analyze the morphological and kinematical properties of the nested density structures and demonstrate that they outline the projection of the three-dimensional structure of the flux rope as it crosses the lines of sight of the WISPR imager, thereby revealing the magnetic field geometry. Comparison of observations from various viewpoints suggests that the CME substructures can be discerned owing to the ideal viewing perspective, close proximity, and spatial resolution of the observing instrument.