bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthobiologic therapies delay the need for hip arthroplasty in patients with avascular necrosis of the femoral head: A systematic review and survival analysis
Authors: Zaffagnini Marco , Boffa Angelo , Andriolo Luca , Raggi Federico , Zaffagnini Stefano , Filardo Giuseppe 
Published: November 2024

ABSTRACTPurposeThe aim of this systematic review and survival analysis was to quantify the benefits of orthobiologic augmentation therapies for the treatment of avascular necrosis (AVN) of the femoral head and identify the most effective approach to delay the need for total hip arthroplasty (THA).MethodsA systematic review of the literature was performed on PubMed, Scopus, and Cochrane on clinical studies on orthobiologic therapies used alone or as an augmentation to core decompression or other procedures to address hip AVN. A qualitative analysis of the different biological therapies applied was performed. Afterward, the results of these procedures were quantitatively analysed to document their survivorship from THA compared to treatment groups without orthobiologics. Kaplan–Meier analysis was performed for all studies and then by categorising orthobiologics into treatment subgroups.ResultsA total of 106 studies were included (4505 patients). Different orthobiologic approaches have been evaluated: cell‐based therapies including bone marrow aspirate concentrate (BMAC) and bone marrow mesenchymal stromal cells (BM‐MSCs), platelet‐rich plasma (PRP), or other bioactive molecules applied in the osteonecrotic area or as intra‐arterial injections. The survival analysis at 120 months documented a higher (p < 0.0005) cumulative survivorship with orthobiologics (69.4%) compared to controls (48.5%). The superiority was shown specifically for BMAC (p < 0.0005), BM‐MSCs (p < 0.0005), intra‐arterial (p < 0.0005) and PRP (p = 0.011) approaches, but the direct comparison of these approaches with their controls confirmed benefits only for BMAC (p < 0.0005).ConclusionThis systematic review and survival analysis demonstrated that orthobiologics have the potential to improve survivorship in patients affected by hip AVN. In particular, the specific analysis of different orthobiologic products supported relevant benefits for BMAC augmentation in terms of survival from the need for THA, while no clear benefits were confirmed for other orthobiologics.Level of EvidenceLevel III.
Arthroscopic meniscal posterior root repair combined with centralization reduces medial menicus extrusion associated with posterior root tears: One‐year clinical outcomes
Authors: Yan Xin , Sahu Souradeep , Li Huijian , Zhou Wei , Xiong Ting , Chen Shenliang , Li Chen , Hao Liang 
Published: November 2024

AbstractPurposeThis study aimed to assess the short‐term clinical efficacy of combining posterior meniscal root repair with meniscal centralization technology in the treatment of medial meniscus posterior root tears (MMPRTs) and notable meniscus extrusion.MethodsIn this retrospective analysis, patients aged 43–76 years with only chronic posterior root tears of the medial meniscus and notable extrusion were followed up for 12–14 months. Inclusion criteria: (1) persistent medial knee joint pain affecting daily life, presenting with joint space tenderness; (2) showing the ineffectiveness of conservative treatment for a minimum of 3 months; conservative treatment includes non‐invasive methods such as nonsteroidal anti‐inflammatory drugs, physical therapy and massage, but does not include intra‐articular injections. (3) Kellgren–Lawrence Grades 0–II osteoarthritis (OA) of the knee joint; and (4) diagnosis of a posterior root tear of the medial meniscus with notable meniscus extrusion confirmed through knee‐joint plain magnetic resonance imaging (MRI) scans, where coronal image revealed a meniscus body extrusion of ≥3 mm. Exclusion criteria: (1) Kellgren–Lawrence Grades III–IV OA in the knee joint; (2) presence of knee joint infection or other structural damage to the knee joint; (3) history of previous knee joint surgery; (4) demonstrating joint instability or abnormal lower‐limb alignment (varus deformity >5°); and (5) presence of severe mental illness, coagulation disorders, or other serious medical conditions. The Lysholms score, the Hospital for Special Surgery (HSS) knee score, the visual analogue scale (VAS) score and meniscal extrusion values were evaluated before and after surgery in 23 patients through a comparative analysis.ResultsThe results of the follow‐up conducted 12–14 months post‐operatively indicated a significant improvement in the patients' conditions. In particular, the Lysholms scores (preoperative: 50.9 ± 10.2; 1‐year post‐surgery: 72.0 ± 8.4), HSS knee scores (preoperative: 45.9 ± 10.6; 1‐year post‐surgery: 79.1 ± 11.1) and VAS scores (preoperative: 4.0 ± 1.1; 1‐year post‐surgery: 0.9 ± 0.7) exhibited notable enhancements. Furthermore, compared to the preoperative values, the degree of meniscus extrusion measured by coronal MRI of the knee joint significantly improved post‐operatively (preoperative: 3.7 ± 0.8 mm; 1‐year post‐surgery: 2.2 ± 0.6 mm). These findings all yielded a p < 0.05, signifying statistical significance.ConclusionIn patients with chronic MMPRTs and notable extrusion, a combination of posterior meniscal root repair and centralization technology can effectively restore meniscus function and rectify the medial meniscus displacement, resulting in favourable short‐term clinical outcomes.Level of EvidenceLevel IV.
Shared genetic architecture of non‐viral cirrhosis with several pleiotropic traits: A nested case‐control study in the UK Biobank
Authors: Byun Jinyoung , Kim Hyun‐Seok , Han Younghun , Thrift Aaron P. , Lin Sabrina M. , Xiao Xiangjun , Lim Hyeyeun , Jun Goo , Desantis Stacia M. , El‐Serag Hashem B. , Kanwal Fasiha , Amos Christopher I. 
Published: November 2024

AbstractBackground and AimsCirrhosis is a leading cause of liver‐related mortality and a multifactorial disease. To date, the complex genetic architecture of non‐viral cirrhosis has not been fully explored. Cross‐trait genetic correlations can elucidate the common genetic aetiology of genetically correlated phenotypes. This study aims to identify polygenic and pleiotropic traits associated with cirrhosis using the linkage disequilibrium score regression analysis.MethodsWe conducted genome‐wide association analysis of 9 622 842 imputed SNPs on 3368 non‐viral cirrhosis cases and 258 258 controls, and cross‐trait analysis between non‐viral cirrhosis and various polygenic and pleiotropic traits using the UK Biobank cohort study. We further performed sensitivity analyses by removing genomic regions of alcohol intake, smoking behaviours and obesity. We observed multiple traits showing robust genetic correlations (rg) with non‐viral cirrhosis.ResultsWe found strong genetic correlations between the genetic architectures of non‐viral cirrhosis and clinical/physiologic factors, including BMI (rg = 0.82), alanine aminotransferase (0.71), diabetes (0.70), number of cigarettes currently smoked daily (0.67), amount of alcohol drunk on a typical drinking day (0.60), insomnia (0.59), gout (0.57), depression (0.50), apolipoprotein‐A (−0.33) and HDL cholesterol (−0.49). Exclusion of genomic regions associated with alcohol intake, smoking behaviours and obesity demonstrated consistent directions and persistent associations in genetic patterns. The inheritability of cirrhosis on the observed scale showed 0.56%.ConclusionsThis study provides a comprehensive assessment of the shared genetic architecture of non‐viral cirrhosis predisposition and numerous polygenic and pleiotropic traits, most notably BMI, alanine aminotransferase and diabetes. These findings provide new information on underlying comorbid conditions that can increase the non‐viral cirrhosis risk.
Wide‐Temperature Persistent Luminescence
Authors: Li Mingxing , You Wenwu , Zhang Xiaomin , Li Jiacai , Zhang Chennan , Xu Zhili , Fan Pingping , Pan Gencai , Mao Yanli 
Published: November 2024

AbstractTraditional persistent luminescence (PersL) materials depend on the distribution of inherent traps within their structure, which are usually narrow and discontinuous, thereby restricting their functionality to a limited temperature range. The development of materials capable of PersL over a wide temperature range, represents a significant hurdle in the advancement of PersL technology. Here, this study deviates from the conventional method of relying on inherent traps and instead harness recoverable Frenkel defects within fluoride materials to broaden the operational temperature range for PersL. Under X‐ray irradiation, Frenkel defects involving the migration of fluorine ions can be generated and recovered in real time, accompanied by the formation and dissipation of localized excitons, ultimately transferring energy to the luminescent centers. Notably, this recovery process is operative at all temperatures and is sufficiently slow‐paced, ensuring that PersL can be observed across every temperature range (77–500K). Building on this mechanism, the production of multicolor wide‐temperature PersL is readily attainable through the straightforward substitution of various luminescent centers. Significantly, X‐ray‐induced recoverable Frenkel defects have the potential to confer the characteristics of wide‐temperature PersL to materials that inherently lack these attributes. This, in turn, provides a new design strategy for developing wide‐temperature PersL materials.
Chiral Self‐Assembly of a Pyrene‐Appended Glutamylalanine Dipeptide and Its Charge Transfer Complex: Fabrication of Magneto‐Responsive Hydrogels and Human Cell Imaging
Authors: Ruidas Pradip , Dubey Soumen Kumar , Hafiz Sk Abdul , Mandal Jishu , Mukherjee Sunil , Ghosh Narendra Nath , Midya Ramkrishna , Roy Dipanwita , Das Dona , Singh Somendra , Neogi Poonam , Saha Sudipta , Roy Ujjal Kanti , Bhattacharyya Sankar , Ghosh Angshuman , Bhattacharjee Subham 
Published: November 2024

AbstractThe formation of a robust, self‐healing hydrogel of a novel pyrene‐appended dipeptide, Py‐E‐A (L‐Glutamic acid short as E; L‐Alanine short as A) is demonstrated. Detailed studies suggest that nanoscopic fibers with a length of several micrometers have formed by chiral self‐organization of Py‐E‐A gelators. Additionally, live human PBMCs imaging is shown using the Py‐E‐A fluorophore. Interestingly, electron‐rich Py‐E‐A couples with electron‐deficient NDI‐β‐A (β‐Alanine short as β‐A) by charge transfer (CT) complexation and forms stable deep violet‐colored CT super‐hydrogel. X‐ray diffraction, DFT, and 2D ROESY NMR studies suggest lamellar packing of both Py‐E‐A and the alternating CT stack in its hydrogel matrixes. Supramolecular chirality of the Py‐E‐A donor can be altered by adding an achiral acceptor NDI‐β‐A. Notably, the fibers of the CT hydrogel are found to be even thinner than the Py‐E‐A fibers, which, in turn, makes the CT hydrogel more tolerant to the applied strain. Further, the self‐healing and injectable properties of the hydrogels are shown. Finally, the magneto‐responsive behavior of the Py‐E‐A and CT hydrogels loaded with spin‐canted Cu‐ferrite (Cu0.6Zn0.4Fe2O4) nanoparticles (NPs) is demonstrated. The presence of magnetic NPs within the hydrogels has changed the fibrous morphology to rod‐like nanoclusters.
Silk Nanofibers/Carbon Nanotube Conductive Aerogel
Authors: Feng Yanfei , Wang Xiaotian , Dai Yunfeng , Feng Siying , Li Lechen , You Renchuan 
Published: November 2024

AbstractNatural silk nanofibers (SNF) are attractive conductive substrates due to their high aspect ratio, outstanding mechanical strength, excellent biocompatibility, and controllable degradability. However, the inherently non‐conductivity severely restricts the potential sensor application of SNF‐based aerogels. In this work, the conductive nanofibrous aerogels with low‐density achieved through freeze–drying by dispersing carbon nanotubes (CNT) into SNF suspension. The addition of CNT significantly increases the conductivity with improved mechanical properties of composite aerogels. SEM results reveal that the distinct hierarchical structure comprising micropores and nanofibrous networks within the pores is formed when CNT content reached 30%. Furthermore, increased cell viability suggested the excellent biocompatibility of SNF‐CNT‐based conductive aerogel for tissue‐engineering applications. Subsequently, the elastic water‐borne polyurethane (WPU) is incorporated to SNF‐CNT system to construct aerogel with good sensing properties. The introduction of WPU demonstrates enhanced compressive performances and an exceptionally high elastic recovery ratio of 99.8%, thereby exhibiting a stable and lossless strain‐sensing signal output at 5% strain. This study provides a feasible choice and strategy for exploring the potential application of SNF in functional aerogels.
The tissue and circulating cell‐free DNA‐derived genetic landscape of premalignant colorectal lesions and its application for early diagnosis of colorectal cancer
Authors: Chen Qingjian , Xu Yu‐Hong , Kang Shiyang , Lin WuHao , Luo Linna , Yang Luping , Zhang Qi‐Hua , Yang Pan , Huang Jia‐Qian , Zhang Xiaoni , Zhang Jing , Zhao Qi , Xu Rui‐Hua , Luo Hui‐Yan 
Published: November 2024

AbstractColorectal adenomas (CRAs) represent precancerous lesions that precede the development of colorectal cancer (CRC). Regular monitoring of CRAs can hinder the progression into carcinoma. To explore the utility of tissue DNA and circulating cell‐free DNA (cfDNA) in early diagnosis of CRC, we retrospectively sequenced paired tissue and plasma samples from 85 patients with conventional CRAs. The genetic alterations identified were compared with those from 78 stage‐I CRC patients (CRC‐I) in the ChangKang project. Within the CRA cohort, we pinpointed 12 genes, notably APC, KRAS, and SOX9, that exhibited significant mutated rates in tissue. Patients harboring KMT2C and KMT2D mutations displayed persistent polyps. By comparing with the mutational profiles of metastatic CRC plasma samples, we found that ZNF717 was exclusively mutated in CRAs, while KMT2C and KMT2D mutations were detected in both CRA and CRC. The presence of cfDNA mutations in plasma was validated through polymerase chain reaction, enhancing the feasibility of using cfDNA mutations for early CRC screening. Compared with CRC‐I, CRAs exhibited a reduced frequency of TP53 and PIK3CA somatic mutations and underwent non‐neutral evolution more often. We established a random forest model based on 15 characteristic genes to distinguish CRA and CRC, achieving an area under the curve of 0.89. Through this endeavor, we identified two novel genes, CNTNAP5 and GATA6, implicated in CRC carcinogenesis. Overall, our findings reveal convincing biomarkers markers for detecting CRAs with a propensity for CRC development, highlighting the importance of early genetic screening in CRC prevention.
Differentiating Essential and Dystonic Head Tremor: Exploring Arm Position Effects
Authors: Hubená Tereza , Hollý Petr , Pavlíková Aneta , Ulmanová Olga , Rusz Jan , Krupička Radim , Růžička Evžen 
Published: November 2024

AbstractBackgroundHead tremor poses diagnostic problems, especially when present as an isolated or predominant symptom.ObjectivesTo assess how maneuvers activating upper limb postural tremor can help differentiate head tremor in essential tremor (ET) from dystonic tremor (DT) in cervical dystonia.Methods48 patients with head tremor (25 ET, 23 DT), underwent clinical examination and accelerometric evaluation of head and upper limb tremor during routine tremor‐inducing tasks.ResultsWhile accelerometric power and clinical scores of head tremor did not significantly differ between patient groups, task‐induced variations revealed distinctions. ET patients exhibited increased head tremor power and clinical scores during forward outstretched and lateral wing‐beating arm positions, unlike DT patients. Coherence between head and upper limb tremor remained consistent. Tremor stability index showed no significant differences.ConclusionsTask‐induced changes in head tremor could aid in distinguishing between ET and DT. Further research is needed to refine diagnostic approaches for head tremor.
“Store Strategy”: A New Omni‐Channel Strategy in Community Group Buying
Authors: Zhang Nana , Yu Lei , Liu Keqi , Ye Zhifei , Jia Mengya 
Published: November 2024

ABSTRACTThis paper explores a new omni‐channel strategy—“store strategy”—in community group buying and investigates the impacts of the application of this strategy on the platform and community leader. Three models are developed: (1) The platform operates only in a single online channel. (2) The platform adopts a store strategy and delegates offline operations to a community leader. (3) The platform adopts a store strategy that includes self‐establishing a store. After comparing different models, some interesting results are obtained as follows: (i) After the store strategy is adopted, the optimal online price remains unchanged, but new offline pricing varies, depending on the offline entry method. (ii) If the cost of the community leader operating the offline channel is low, the proportion of private consumers is particularly high. In this case, the store strategy that delegates operations to the community leader will achieve a win–win outcome. (iii) If the self‐established cost is low and the proportion of private consumers is low, the store strategy with a self‐establishing store will allow the platform to obtain higher profits, while greatly harming the community leader.
An energy‐conserving dose summation method for dose accumulation in radiotherapy
Authors: Zhong Hualiang 
Published: November 2024

AbstractBackgroundRadiation therapy often requires the accumulation of doses from multiple treatment fractions or courses for plan evaluation and treatment response assessment. However, due to underlying mass changes, the accumulated dose may not accurately reflect the total deposited energy, leading to potential inaccuracies in characterizing the treatment input.PurposeThis study introduces an energy‐conserving dose summation method to calculate the total dose in scenarios where patients experience changes in body mass during treatment.Methods and materialsThe proposed method transfers dose and mass data from dosimetry images, where the delivered doses were calculated, to a reference image using an energy and mass‐conserving dose reconstruction technique. The reconstructed dose assumes the same resolution and dimension as the reference image. The transferred masses are averaged at each image voxel in the reference image to generate an average mass. The transferred doses are then adjusted by multiplying by the ratio of their transferred mass to the average mass, and subsequently summed to calculate a mass‐weighted (MW) total dose at each voxel. This method is demonstrated with a case of lung cancer retreatment.ResultsThe MW total dose was shown to be equivalent to the total deposited energy divided by the average mass. In the lung cancer retreatment case, the energy derived from the MW total dose was consistent with the sum of energy transferred from two treatments across all evaluated organs.ConclusionThe MW dose summation method can produce a total dose that accurately reflects the total energy deposited in each organ. The consistency may provide a robust foundation for verifying dose accumulations in adaptive radiotherapy.
Design, manufacturing, and multi‐modal imaging of stereolithography 3D printed flexible intracranial aneurysm phantoms
Authors: Yalman Alain , Jafari Arman , Léger Étienne , Mastroianni Michael‐Anthony , Teimouri Kowsar , Savoji Houman , Collins D. Louis , Kadem Lyes , Xiao Yiming 
Published: November 2024

AbstractBackgroundPhysical vascular phantoms are instrumental in studying intracranial aneurysms and testing relevant imaging tools and training systems to provide improved clinical care. Current vascular phantom production methods have major limitations in capturing the biophysical and morphological characteristics of intracranial aneurysms with good fidelity and multi‐modal imaging capacity. With stereolithography (SLA) 3D printing technology becoming more accessible, newer flexible and transparent printing materials with higher precision controls open the door for improving the efficiency and quality of producing anthropomorphic vascular phantoms but have rarely been explored for the application.PurposeThis technical note intends to report the feasibility of using SLA 3D printing technology to manufacture flexible intracranial aneurysm phantoms with similar scales to the real anatomy, as well as their capacity for multi‐modal flow imaging and analysis, including ultrasound flow imaging, high‐speed filming, and particle image velocimetry analysis.MethodsWe designed and 3D‐printed two intracranial aneurysm phantoms with an SLA 3D printer using Formlabs Elastic 50A resin. By using a micropump to introduce cyclical flows in the phantoms, we first employed conventional Doppler and vector flow ultrasonography to observe and measure different fluidic properties. Then, a high‐speed camera was used to record particles flowing within the phantom, and we further conducted a particle image velocimetry analysis, including the distribution of mean 2D velocity vectors, average velocity magnitudes, and the mean vorticity fields in the phantom for the high‐speed imaging data.ResultsWe successfully 3D‐printed flexible intracranial aneurysm phantoms with similar dimensions to the real anatomy. Additionally, we validated the phantoms’ ability to allow visualization, measurement, and analysis of flow dynamics based on both real‐time ultrasound and optical imaging.ConclusionsOur proof‐of‐concept study illustrates that SLA 3D printing using commercial elastic resins can significantly contribute towards facilitating the fabrication of flexible intracranial aneurysms phantoms for training, research, and preoperative planning.