bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embedding and assessing project based statistics
Authors: Marshall Ellen 
Published: May 2019

Traditional approaches to learning and teaching in statistics often involves the passive absorption of information through lectures, a focus on mathematical theory and assessments which test mastery of procedures. This often results in students struggling to apply their statistics knowledge in practical and authentic contexts particularly within final year projects and in the workplace. For some time, statistics educational literature has recommended shifting the focus of teaching and assessment from theory to statistical problem solving, application based statistics using real-life scenarios, and effective communication of statistics. This research has led to the production of guidelines for statistics educators from the American Statistical Association.This paper discusses how educational literature and guidelines have been used to implement changes in the teaching of a first year probability and statistics module for mathematics undergraduates at Sheffield Hallam University. Changing to project based learning with a focus on active learning, effective decision making and communication enabled students to successfully undertake an open group project by the end of their first year. In addition, attendance, engagement and understanding were noticeably improved. The rationale, challenges and benefits to changing the focus of the course and also the teaching style are discussed.
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a case-control study
Authors: Guinot Pierre-Grégoire , Spitz Alexandra , Berthoud Vivien , Ellouze Omar , Missaoui Anis , Constandache Tiberiu , Grosjean Sandrine , Radhouani Mohamed , Anciaux Jean-Baptiste , Parthiot Jean-Philippe , Merle Jean-Pierre , Nowobilski Nicolas , Nguyen Maxime , Bouhemad Belaid 
Published: May 2019

Abstract
Background
No study has demonstrated feasibility and improvement of opioid free anaesthesia in cardiac surgery. The objective of the present study was to evaluate the effect of opioid-free anaesthesia (OFA) on post-operative morphine consumption and the post-operative course.
Methods
We performed a retrospective matched cohort study (1:1) in cardiac surgery with cardiopulmonary bypass. Patients were divided into two groups: OFA or opioid anaesthesia (OA). The main outcome was the cumulated total morphine consumption during the 48 post-operative hours. The secondary outcomes included rescue analgesics, a major adverse event composite endpoint, and the length of stay (LOS) in the ICU and in hospital.
Results
110 were matched (OFA: n=55; OA: n=55). On inclusion, OFA and OA groups did not differ significantly in terms of demographic and surgical data. The total morphine consumption was higher in the OA group than in the OFA group (15 (6-34) mg vs 5 (2-18) mg, p=0.001). Analgesic rescue did not differ between the two groups. The pain score during the first 48 post-operative hours did not differ between the two groups. Incidence of the composite endpoint was lower in the OFA group (25 patients (43%) vs 38 patients (68%), p=0.021) in relation to lower use of non-invasive ventilation (15% vs 49%, p=0.032). The time to extubation and the ICU stays were shorter in the OFA group (3 (1-5) vs 5 (3-6) hours, p=0.001 and 2 (1-3) vs 3 (2-5) days, p=0.037).
Conclusion
The use of an OFA was associated with a decreased consumption of morphine and shorter ICU stays. Further randomized studies are needed to confirm these results.
miR-4454 up-regulated by HPV16 E6/E7 promotes invasion and migration by targeting ABHD2/NUDT21 in cervical cancer
Authors: Wang Hui , Hu Hui , Luo Zhenzhao , Liu Shuiyi , Wu Wangze , Zhu Man , Wang Jing , Liu Yingle , Lu Zhongxin 
Published: May 2019

Abstract
The abnormal expression of HPV16 E6/E7 activates oncogenes and/or inactivates tumor suppressor genes, resulting in the selective growth and malignant transformation of cancer cells. miR-4454 was selected by sequencing due to its abnormal high expression in HPV16 E6/E7 positive CaSki cell compared with HPV16 E6/E7 negative C33A cell. Overexpression of miR-4454 enhances cervical cancer cell invasion and migration. ABHD2 and NUDT21 is identified as a target gene of miR-4454.The effects of ABHD2 and NUDT21 on migration and invasion of CaSki and C33A cells were determined. The dual luciferase and RT-qPCR assays confirmed that miR-4454 might regulate its targets ABHD2 and NUDT21 to promote the proliferation, invasion and migration, whereas, inhibit the apoptosis in CaSki and C33A cells.
Source separation and apportionment of surface water pollution in the Luanhe River Basin based on non-negative matrix factorization
Authors: Leng Peifang , Zhang Qiuying , Li Fadong , Zhang Yizhang , Gu Congke 
Published: May 2019

Abstract
Understanding the spatial and temporal variations and source apportionment of water pollution is important for efficient water environment management. The non-negative matrix factorization (NMF) method, which is naturally well suited for non-negative data of high dimension, was used to identify the latent factors and apportion the contributions from identified pollution sources to each water quality parameter. We obtained a data matrix with 11 water quality variables collected from 2013 to 2016 in the Luanhe River Basin in northern China. The results highlight the substantial contribution of industrial and livestock wastewater. All land-use types have a slightly weaker impact on surface water pollution during the dry season than during the rainy season. The aim of this study is to illustrate the practicability of multivariate statistical analysis, especially the application of NMF, which has major potential for source separation and the apportionment of water pollution.
Tiapride for the Treatment of REM Sleep Behaviour Disorder in Dementia with Lewy Bodies: A Case Series
Authors: Adler Georg , Mautes Angelika E. 
Published: May 2019

Objective:
REM sleep Behaviour Disorder (RBD) in Dementia with Lewy bodies (DLB) may be attributed to a decrease in dopaminergic neurotransmission. Thus, we studied the therapeutic efficacy of the pre and postsynaptic D2 and D3 receptor antagonist tiapride, which at a low dosage preferentially blocks presynaptic dopamine receptors and consequently leads to feedback activation of dopamine synthesis and to increased extracellular levels of dopamine.

Methods:
Six consecutive patients presenting at our memory clinic with RBD in DLB, in whom melatonin had been ineffective and clonazepam was found inappropriate for clinical reasons, were treated with triapride at dosages between 50 and 150 mg for twelve weeks.

Results:
Tiapride was well tolerated by all patients. Five of the six patients, reported was a decrease of the self-perceived frequency of bad dreams and the intensity and severity of motor and vocal enactments during sleep. In four of these six patients, this was also the case in the view of the patients’ bed partners.

Conclusion:
Tiapride may by an effective and well-tolerated treatment for RBD in patients with DLB.
Family Medicine Trainees’ Knowledge about Topical Corticosteroids in Jeddah, Saudi Arabia
Authors: Kokandi Amal A 
Published: May 2019

Background:Topical corticosteroids (TCS) are used to treat a variety of dermatological conditions. The fear of side effects sometimes affects the adherence to treatment. The aim of this study was to assess the knowledge and the attitude of family medicine residents under training for the use of TCS.Methods:Family medicine trainees attending an educational session were surveyedvialive electronic questionnaires.Results:A total of 89 (out of 100 who attended the event) people responded to the questionnaire. Undergraduate teaching was the main source of information about TCS. Most of the respondents advised the use of TCS sparingly or using finger-tip unit amount. More than half of them thought TCS can be absorbed and it should not be used to some body areas such as eyelids. Majority of the respondents did not think that TCS use can lead to infections, weight gain or obesity, damage the skin if used for a few weeks, negatively affect health or lead to asthma. More than 40% thought that it is better to stop TCS treatment as soon as possible in atopic dermatitis patients.Conclusion:Family medicine trainees have some fears and misconceptions regarding TCS use. There is a need to increase the knowledge about TCS in undergraduate and postgraduate teaching.
Recent Advances and Novel Approaches for Nose to Brain Drug Delivery for Treatment of Migraine
Authors: Sachan Nidhi , Bahadur Shiv , Sharma Pramod K. 
Published: May 2019

Background:Nasal drug delivery has been used since ancient times for therapeutic and recreational purposes. For the last decades, nasal drug delivery has been extended for drug delivery to the brain. Therefore, it is important to understand the several physiological and physicochemical factors of the nose for brain drug delivery.Objective:A major highlight of the present review article is the several aspects of the nose to brain delivery for migraine treatment. This review will help to understand different factors which are needed to be considered for intra-nasal formulations to achieve the desired therapeutic effects.Method:There are different drug delivery routes available for migraine treatment. Nasal route of administration may be optimal for migraine treatment which has better drug concentration in the brain. These approaches may be associated with limiting the adverse effects of drug therapeutics.Results:A list of total FDA approved approaches has been provided. Novel approaches used for drug targeting to get maximum drug concentration in the brain have been highlighted. Several novel drug delivery approaches such as nanoparticle, nanoemulsion, microspheres, etc. have been reported and better therapeutic effects have been observed. Among the novel approaches, some of them are currently under either Phase II or Phase III development but may prove to offer better clinical effects. These approaches would become the alternate choice for migraine treatment with patients experiencing symptoms consistent with gastrointestinal dysfunction associated with migraine.Conclusion:Intra-nasal administration of drugs for migraine treatment may offer an interesting alternative for achieving therapeutic effects of drugs which are comparable to the parenteral route. Nasal drug delivery can be an alternative route of drug administration for migraine treatment to achieve better bioavailability.
AUTHENTICATION OF PATIN (PANGASIUS MICRONEMUS) FISH OIL ADULTERATED WITH PALM OIL USING FTIR SPECTROSCOPY COMBINED WITH CHEMOMETRICS
Authors: Putri Anggita Rosiana , Rohman Abdul , RIYANTO SUGENG 
Published: May 2019

Objective: The goal of this research was to perform authentication of patin (Pangasius micronemus) fish oil (PFO) adulterated with palm oil (PO) using FTIR spectroscopy combined with chemometrics method.
Methods: Patin fish oil (PFO) and PFO adulterated with palm oil (PO) were measured using FTIR instrument at wavenumbers region of 4000–650 cm-1. The chemometrics methods, namely multivariate calibration of partial least square (PLS) and principal component regression (PCR) were used to make calibration and validation models during quantification. Discriminant analysis (DA) was used to make grouping pure PFO and PFO adulterated with PO.
Results: The results showed that PLS and PCR could be used to quantify PO as adulterant in PFO, either in calibration or validation models. FTIR spectroscopy combined with multivariate calibration offered accurate and precise method for quantitative analysis with R2 value of >0.999 and low RMSEC and RMSEP. DA was capable of grouping PFO and PFO adulterated with PO with an accuracy level of 100%.
Conclusion: FTIR spectroscopy combined with chemometrics could be reliable technique for quantification and discrimination of PFO and PFO adulterated with PO.
RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF ASIATIC ACID ISOLATED FROM THE PLANT CENTELLA ASIATICA.
Authors: Hebbar Srinivas , Dubey Akhilesh , G. S. RAVI , Kumar Hemanth , Saha Santhanu 
Published: May 2019

Objective: Asiatic acid is a triterpene saponin and the main constituent of the species Centellaasiatica. The current study aimed to isolate, characterize and develop an analytical method for asiatic acid in the shorter run time with good efficiency.
Methods: In this study isolation of asiatic acid was achieved by TLC and thus isolated asiatic acid was characterized by 1HNMR spectral analysis and LCMS. An isocratic RP-HPLC method was established for the assessment of asiatic acid from the methanol extract of Centellaasiatica. The chromatographic separations were achieved by RP-C18 column 250x4.6 mm (5µ Particle size) Shimadzu UFLC pump LC 20AD and mobile phase composed of 0.1% orthophosphoric acid: acetonitrile (50:50). The analysis of column effluents was achieved using a PDA detector (Photo Diode Array) at 210 nm, and the flow rate was recorded 1 ml/min.
Results: Soxhlet extraction process followed by fractional extraction using different solvents was performed. Methnol extract was taken to isolate asiatic acid by TLC (RF 0.97) and base peak from mass spectra was found to be 489M+which was confirmed successful isolation. Retention time of asiatic acid was found to be 9.6±0.22 min. This method obeyed linearity over the concentration range of 10-50µg/ml and regression coefficient was obtained from the alinearity plot for asiatic acid which was found to be 0.9987 LoD and LoQ were obtained to be 0.784507µg/ml and 2.615µg/ml respectively. RSD of mean assay values was found to be 1.02%. Since there were no marked changes in the performance characteristics of the method.
Conclusion: Isolation, characterization and identification of asiatic acid were achieved significantly which will be useful for the standardization of herbal formulation containing asiatic acid.
SYNTHESIS AND CHARACTERIZATION OF THIOLATED JACKFRUIT SEED STARCH AS A COLONIC DRUG DELIVERY CARRIER
Authors: Das Sanjoy , Das Malay K. 
Published: May 2019

Objective: Site-specific drug delivery into the colonic region is extremely fascinating for local treatment of various colonic diseases like ulcerative colitis, colon cancer but it should be capable of saving the drug from hydrolysis and degradation. The present study reports the application of jackfruit seed starch and its thiol derivative as a drug delivery carrier for the colon.
Methods: The starch was extracted from the jackfruit seeds by water extraction method and modified by the esterification reaction with thioglycolic acid. The thiolated starch was characterized for morphology, functional and flow properties. The safety profile of the thiolated starch was confirmed by acute toxicity study in a mice model as per OECD guidelines 423. The microspheres based on thiolated starch were prepared by ionic gelation method incorporating Ibuprofen as a model drug. The prepared microspheres were characterized for particle size, drug entrapment efficiency, drug loading, compatibility study, surface morphology, in vitro drug release and release kinetics.
Results: The result attributed that starch was successfully modified by the thiolation with a degree of substitution of 3.30. The size of prepared microspheres ranges from 825.5±4.58 to 857±6.24 µm, the entrapment efficiencies ranges from 69.23±1.19 to 76.15±0.83 % and the drug loading capacity ranges from 17.75±0.30 to 46.05±0.49 %. The FT-IR, DSC and XRD studies confirmed that there is no interaction within drug and excipients. The thiolated starch microspheres show the maximum release of drug at pH 7.4 in the presence of rat caecal content as compared to pH 1.2 and pH 6.8 for up to 24 h and are following first order release kinetics.
Conclusion: These results suggest the application of thiolated jackfruit seed starch could be promising as a long-term drug delivery carrier for the colon.
HPLC METHOD DEVELOPMENT FOR THE ANALYSIS OF BISOPROLOL IN COMBINED DOSAGE FORM CONTAINING BISOPROLOL AND ENALAPRIL AND IN VITRO DISSOLUTION STUDIED
Authors: Logoyda Liliya , Kovalenko Sergiy , Abdel-Megied Ahmed M. , Zhulkevych Igor , Drapak Iryna , Demchuk Inna , Netsyuk Oleh 
Published: May 2019

Objective: A simple, rapid and reproducible HPLC method was developed for the determination of bisoprolol in experimental combined dosage forms containing bisoprolol and enalapril and for drug dissolution studies.
Methods: A C18 column (Hi Qsil C18, 5 μm, 4.6х250 mm) and a mobile phase methanol: phosphate buffer solution (65:35, v/v) mixture were used for separation and quantification. Analyses were run at a flow rate of 1.0 ml/min and at ambient temperature. The injection volume was 300 μL and the ultraviolet detector was set at 225 nm. The method was validated as per ICH guidelines.
Results: Under these conditions, bisoprolol was eluted at 4.75 min. Total run time was shorter than 6 min. A linear relationship between the concentration and the area of ​​chromatographic peaks of bisoprolol in the range of 0.625 mg/ml-5.000 mg/ml (3.750 mg/ml at pH 1.2) has been established. In the medium with pH 1.2 release of bisoprolol from tablets in 5 min is 38.42%, and after 15 min-85.51%, in medium with pH 4.5 the release of bisoprolol from tablets in 5 min makes 59.78%, and after 15 min-103.71%; in a medium with pH 6.8, the release of bisoprolol from tablets in 5 min is 61.29%, and after 15 min-85.90%.
Conclusion: The developed method was applied successfully for quality control assay of bisoprolol in experimental tablets and in vitro dissolution studies.
El diseño y la planeación de secuencias didácticas como herramientas para generar ambientes aprendizaje en educación a distancia y mixta
Authors: Martínez Quezada Carlos José , Núñez Guzmán Sandra Teresita , González Moreno Guillermo 
Published: May 2019

<p>El bachillerato en modalidad mixta está conformado, en su mayoría por adultos que desean crecer profesionalmente, situación que en gran medida se concretiza al obtener el certificado de bachillerato. Es indispensable que quienes estudian nivel medio superior en modalidades mixtas y a distancia, lo hagan desde modelos basados en competencias pues el sector empresarial, y los estudiantes, esperan aplicar de manera inmediata el avance alcanzado en la adquisición de su perfil de egreso. </p><p>En este trabajo se ofrece un conjunto de herramientas que permiten al asesor, en modalidades mixtas y a distancia, desarrollar estrategias que le auxilien al generar ambientes de aprendizaje alineados constructivamente; con el único objetivo de que el estudiante sea capaz de construir conocimientos, volver los aprendizajes significativos y expresarlos en diversas competencias, de acuerdo a los perfiles de egreso esperados.</p>
Review of IPSS Questionnaire in Postoperative Transurethral Resection of Prostate (TURP) for Streamlining Follow-up Protocols
Authors: Broadley Graham , Delves George , Khwaja Sikander 
Published: May 2019

Objective Clarify the role of IPSS questionnaire for post TURP operation patients, to assess and streamline best follow-up protocols Materials and Methods We identified 87 consecutive patients over 6 months undergoing standardized bipolar TURP. We retro-spectively reviewed patients at 3 months in follow-up clinic, where we performed tests including Qmax, Post-void residual (PVR) and IPSS (International Prostate Symptom Score). We identified patients who were discharged or underwent a change in standard management at this point, and used ROC (Receiver Operating Curve) curve analysis to identify the tools which showed the best ability to predict this decision. Results ROC curve analysis suggested Qmax (AUC: 0.7751) and IPSS (AUC 0.8571) were the best tools to predict a change in management. Given the IPSS tool is a questionnaire, thus holding most promise to streamline protocols, we applied Youden-J test to show IPSS=8 cut-off was best to identify management changes. Conclusion The IPSS tool is able to predict a need for change in management in post TURP patients at 3 months. This will allow a simple triage system to provide an efficient and effective decision-making process for discharge without the need for clinic attendance.
Propriedade intelectual e acumulação de capital
Authors: Moura Pollyanna Paganoto 
Published: May 2019

Este trabalho tem por objetivo apresentar uma compreensão sobre a dinâmica da produção intelectual no ciclo do capital industrial. Buscaremos visualizar como o conhecimento, na forma da propriedade intelectual, pode ser apreendido no processo de produção capitalista e quais os impactos do mesmo no circuito de acumulação. Procuraremos com isso desvendar como se determina seu preço. A teoria do valor de Marx, a partir de categorias como a mais valia extra e a renda da terra, se mostrará como ferramenta eficaz para o desenvolvimento de tal compreensão.
Samanaikaisesti hauras ja resilientti - kategoria-analyysi ikääntyneiden itseä koskevasta puheesta
Authors: Outila Marjo , Lantela Pilvikki 
Published: May 2019

Vanhenemiseen liittyvä kulttuurinen kuvasto rakentuu helposti kaksijakoisesti. Janan toisessa päässä ovat aktiiviset, elämästä nauttivat ja yhteiskuntaan panoksensa antavat seniorikansalaiset ja toisessa päässä tarvitsevat ja sairaat vanhukset. Tarkastelemme tässä artikkelissa ikääntyneiden lappilaisten kerrontaa itsestään arkielämän kontekstissa. Tutkimuksen aineisto koostuu 16 ikääntyneen haastatteluista, jotka tehtiin kotiteknologiakokeilun yhteydessä eri puolilla Lappia vuosina 2017-2018. Aineisto on analysoitu kategoria-analyysillä ja tulkinnassa on käytetty resilienssin ja haurauden käsitteitä. Kaikki haastateltavat sijoittivat puheessa itsensä kategorioihin, joiden voidaan katsoa kiinnittyvän haurauteen ja resilienssiin. Voimien väheneminen, kivut ja luopuminen, toisin sanoen hauraus, oli osa ikääntyneiden elämäntodellisuutta. Tämä ei kuitenkaan poissulkenut resilienssiä: ikääntyneiden pystyvyyttä tai asemoitumista oman arkensa aktiivisiksi toimijoiksi. Ikääntyneitä ei tulisi tarkastella yksipuolisesti vain haurauden tai resilienssin näkökulmista, vaikka he ensi silmäyksellä näyttäisivätkin kuuluvan vain toiseen kategoriaan, vaan nämä molemmat ulottuvuudet tulisi nähdä luontevana osana ikääntymistä ja ikääntymisen kulttuurisia käsikirjoituksia. Ikääntyneillä tulisi olla mahdollisuus toimia ja osallistua, mutta samalla mahdollisuus olla täysivaltaisena aikuisena myös tarvitseva, heikko tai hauras.
Exclusiones sindicales femeninas
Authors: Rodríguez Tania Julieta , Cuéllar Camarena María Andrea 
Published: May 2019

¿Qué es lo que explica la distancia entre la presencia de las trabajadoras en el mercado de trabajo y la participación en los espacios de poder? ¿En qué medida es posible el ejercicio de la igualdad de género en estructuras que refuerzan la socialización en roles tradicionales, como las sindicales? En este trabajo estudiamos las formas de participación de mujeres en los sindicatos y la construcción de prácticas igualitarias de acceso a los espacios de poder, entendidas como el derecho a participar de la gestión y decisión en las instituciones que cristalizan circuitos de construcción y reproducción de poder.
En primer lugar, analizamos cómo fue que la separación de las esferas pública y privada hicieron a la división sexual del trabajo. En segundo lugar, nos preguntamos de qué modo la condición androcéntrica del Derecho opera al construir esa única forma de ser mujer, atravesada por diversos ejes de subordinación que refuerzan la estratificación en la sociedad. En tercer lugar, indagamos sobre la distancia entre la participación de las mujeres en espacios de trabajo fuertemente feminizados y su presencia en los lugares de poder; desde una perspectiva crítica sobre justicia de género y el pleno ejercicio de la ciudadanía de las mujeres, en ámbitos que refuerzan las prácticas sexistas, como son los sindicatos. Finalmente, incluimos la experiencia de las asambleas de mujeres que se realizaron de frente al Paro Internacional del 8 de Marzo de 2018, para pensar aspectos sobre el ejercicio del poder desde una perspectiva feminista.