bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calling a Notary by Police Investigator Regarding the Relaas Deed Made by a Notary (Case Study at Unit I Pidum Sat Reskrim West Lombok Regional Police)
Authors: Sarwoto Lalu Henry , Parman Lalu , Munandar Aris 
Published: May 2019

In Article 66 of Law No. 2 of 2014 in conjunction with Law No. 30 of 2004 concerning Notary Position (UUJN), namely: a. If needed by law enforcers in the judicial process, namely the investigator, public prosecutor or judge can submit a request for approval in order to summon a notary. The letter was submitted to the Honorary Board of Notaries; b. Within a maximum of 30 working days from the receipt of the letter of request, the Honorary Board of Notaries must provide the answer; c. If within the period of time determined by the Honorary Board of Notaries does not provide the answer, then the notary Honorary Council's silence is deemed to have received the request for approval. So that law enforcement can make calls to the notary concerned; d. After obtaining approval from the Notary Honorary Assembly, law enforcers are authorized to: 1. Request and take a photocopy of the Minuta deed and / or letters that have been attached to the Minuta deed in the notary deposit (notary protocol); 2. Calling a notary to attend the criminal examination process relating to the notary deed or protocol that is in storage. This type of thesis is normative juridical research that is descriptive analytical, meaning that a data analysis based on general legal theory is applied to explain another set of legal materials.
Conclusion: 1. Investigators are authorized to examine Notaries, where Investigators are authorized to receive reports or complaints about criminal acts, seek information and evidence, order to stop suspected persons or ask and examine personal identification and conduct other actions according to law, they can also acting on the orders of investigators to make arrests, forbid leaving search sites and confiscating them. 2. The procedure of investigation is carried out on a Notary after reporting on the Deed made by a Notary, and in the report stated that the Notary has committed a Criminal Act as stipulated in Article 66 of the UUJN. However, the summons of a Notary as a witness, suspect or defendant after the investigator submits a written request to the Regional Supervisory Board and the request is sent to the Notary by making an excuse rather than calling the Notary as a witness, suspect or defendant. After the issuance of the new Notary Position Act, based on Article 66 paragraph I of Act Number 2 of 2014 concerning the current Notary Position, the summons made by the investigator is considered valid if the investigator mentions the reason for the summons clearly, and the caller is Acts that are accountable according to the law are not in conflict with the law, in line with legal obligations, reasonable, reasonable within the investigator's office, based on proper consideration and respect for human rights.
Notary Authority Based on Article 15 Paragraph (2) Letter F of Notary Position Act
Authors: Wiharja I Wayan Tri Wira , Amiruddin  , Sahnan  
Published: May 2019

Notaries have a very important role in legal traffic, especially in the field of civil law, because a notary is domiciled as a public official who has the authority to make other deeds and authorities. One of the authorities granted is to make a deed relating to land, as referred to in Article 15 paragraph (2) letter F of the Notary Position Act.
This research shows the authority of the notary in making land deeds in a narrow sense, namely the Power of Attorney Charges Mortgage (SKMHT) and in the broad sense namely the Roya Concert Act, the Right of Release Deed, the Declaration of inheritance rights for Indonesian citizens of the Chinese group. The power of attorney to impose liability the juridical implication is a power of attorney that cannot be withdrawn and does not end by any reason except with the making of the deed of rights to give the dependent. The deed of Roya concentration has a position as a substitute certificate of liability in the write-off of mortgage rights and has no executive power. With respect to the rights release deed, the juridical implications lead to the release of land rights from holders of ownership rights to individual land to the rights applicant, namely a private legal entity, first released to the state accompanied by compensation. Regarding the certificate of inheritance rights made by a notary for Indonesian citizens of Chinese descent the juridical implication is the basis for determining rights as heirs in the transfer of rights on the basis of inheritance.
Using the Mass Observation Project: A Case Study in the Practice of Reusing Data
Authors: Courage Fiona 
Published: May 2019

Mass Observation was founded in 1937 to collect subjective, qualitative data on everyday life in Britain, and has continued to record the ordinary and the everyday ever since. Mass Observation’s purpose has always been to make the data it collects available to a range of disciplines to apply their own methodological approaches upon, resulting in data that can be reused within different projects and disciplines. This paper will use Mass Observation as a case study to illustrate how a sociological shift in attitude towards subjective data has played out in the use of a dataset traditionally viewed as a historical archive. I will review how the data itself is used to define and design methods of analysis, examining the epistemological implications of this approach to research design and the new dimension to the researcher-data subject relationship that is introduced. I will conclude by suggesting that research using Mass Observation exemplifies the methodological opportunities and insights that can be gained by adopting a broader, multi-disciplinary research approach to reusing data.
Primary pterygium is not associated with corneal endothelial cell decrease in a rural Chinese population
Authors: Hu Yijun , Atik Alp , Li Li , Qi Wei , Liu Zhenhao , Liu Yingpeng , Yuan Ling 
Published: May 2019

Abstract
Purpose: To investigate corneal endothelial cell density (ECD) in eyes with primary pterygium.

Methods: We first conducted a retrospective study to compare the ECD between 1670 eyes with primary pterygium and 4060 eyes without pterygium. Then we designed a prospective study to confirm the findings of our retrospective study in 95 patients with unilateral primary pterygium.

Results: In the retrospective study, the mean ECD in eyes with primary pterygium (2453±306 cells/mm2) was significantly lower than those in eyes without pterygium (2529±313 cells/mm2, P<0.0001). However, the difference was not as high as previously reported (76 cells/mm2, 3.1%). In the prospective study, there was no significant difference in mean ECD in eyes with unilateral primary pterygium (2480±263 cells/mm2) and the contralateral eyes with no pterygium (2527±277 cells/mm2, P=0.20). There was also no significant difference in hexagonality (P=0.10) or coefficient of variation of size (P=0.15) of corneal endothelial cells between eyes with pterygium and the contralateral eyes with no pterygium.

Conclusion: Primary pterygium may not be associated with a decrease in ECD in our study population of rural Chinese patients.
Comparison of marsupialization under nasal endoscopy versus Lacrimal probing for treatment of congenital dacryocystoceles: a report of 40 cases
Authors: Cui Yanhui , Sun Peng , Tang Lixing , Zhang Chengyue , Wu Qian , Yu Gang , Li Li , Wei Wen Bin 
Published: May 2019

Abstract
Introduction

This study was performed to compare the efficacy of marsupialization under nasal endoscopy versus Lacrimal probing in the treatment of congenital dacryocystocele.

Methods

Forty neonates (43 eyes) diagnosed with congenital dacryocystoceles were divided into Group A (nasal endoscopic marsupialization) and Group B (Lacrimal probing). The patients were followed up for 1 year after surgery. The efficacy, incidence of complications, and reoperation rate were compared between the two groups.

Results

The male:female ratio was 25:15 patients (27:16 eyes). In Group A, the success rate was 100%, the incidence of complications was 5%, and the reoperation rate was 0%. In Group B, the success rate was 90%, the incidence of complications was 20%, and the reoperation rate was 30%.

Conclusion

Compared with Lacrimal probing, marsupialization under nasal endoscopy provides greater efficacy and safety for congenital dacryocystoceles.
The spatial patterns of taxonomic and phylogenetic diversity of seed plants with the climate factors across Ethiopia and Eritrea
Authors: Boru Biyansa H. , Wang Shengwei , Ochola Anne C. , Njogu Antony W. , Xin Haiping , Wang Qingfeng , Zhou Yadong 
Published: May 2019

Abstract
Back ground

Biodiversity is the basic units and measures of the health of ecosystems that provide diverse goods and services for the well-being of human societies and other life forms. However, in this era due to the threats from climatic change and other human-driven environmental changes the earth’s biodiversity is in a grave danger in the world wide. Here, we explored and mapped how the patterns of plant taxonomic diversity, phylogenetic diversity and structures vary across the geographical regions and with respect to climatic factors in Ethiopia and Eritrea in the horn of Africa by using different analyzing methods and diversity measuring indices for the same reasons.

Results

Our analysis showed varied spatial distribution patterns of plant diversity across the region and with the gradients of climatic factors. While the central and southern highland parts of Ethiopia were found to be the primary centres of taxonomic diversity, the centres with higher evolutionary diversity were found scattered in the region. The phylogenetic community structures also vary greatly. About 70% of the plant communities in the region showed phylogenetically clustering patterns. Significant and different relationships were observed between the climatic variables and plant diversity and phylogenetic structures. Generally mean annual temperature and precipitation were respectively found to negatively and positively impact the patterns of plant diversity in the region while variable patterns were observed among different plat life forms. The phylogenetic structure patterns of woody and herbaceous plant groups in terms of NRI were found to be differently impacted by climatic factors.

Conclusions

The patterns of plant diversity both from taxonomic and evolutionary perspectives vary greatly across the geographic and with climatic gradients in Ethiopia and Eritrea. Phylogenetic clustering patterns dominate the plant community assembly in the region though considerable areas were found with communities of phylogenetically overdispersing patterns. The patterns observed from evolutionary perspectives can provide more crucial information for conservation plans. It provide insights that enable the areas with high evolutionary diversity and phylogenetically overdispersing community assemblages to gain as much conservation attention as that of areas with high taxonomic diversity, given their species richness.
Rapid adaptation of signaling networks in the fungal pathogen Magnaporthe oryzae
Authors: Bohnert Stefan , Antelo Luis , Grünewald Christiane , Yemelin Alexander , Andresen Karsten , Jacob Stefan 
Published: May 2019

Abstract
Background
One fundamental question in biology is how the evolution of eukaryotic signaling networks has taken place. “Loss of function” (lof) mutants from components of the high osmolarity glycerol (HOG) signaling pathway in the filamentous fungus Magnaporthe oryzae are viable, but impaired in osmoregulation.
Results
After long-term cultivation upon high osmolarity, stable individuals with reestablished osmoregulation capacity arise independently from each of the mutants with inactivated HOG pathway. This phenomenon is extremely reproducible and occurs only in osmosensitive mutants related to the HOG pathway – not in other osmosensitive Magnaporthe mutants. The major compatible solute produced by these adapted strains to cope with high osmolarity is glycerol, whereas it is arabitol in the wildtype strain. Genome and transcriptome analysis resulted in candidate genes related to glycerol metabolism, perhaps responsible for an epigenetic induced reestablishment of osmoregulation, since these genes do not show structural variations within the coding or promotor sequences.
Conclusion
This is the first report of a stable adaptation in eukaryotes by producing different metabolites and opens a door for the scientific community since the HOG pathway is worked on intensively in many eukaryotic model organisms.
Integrated analysis of DNA methylome and transcriptome reveals the differences in biological characteristics of porcine mesenchymal stem cells from bone marrow and umbilical cord
Authors: Yang Yalan , Liu Zhiguo , Zhao Weimin , Huang Lei , Wu Tianwen , Mu Yulian , Li Kui 
Published: May 2019

Abstract
Background

Bone marrow (BM) and umbilical cord (UC) are the main sources of mesenchymal stem cells (MSCs). These two MSCs display significant differences in many biological characteristics, yet the underlying molecular mechanisms need to be explored.

Results

In this study, to better understanding the biological features of MSCs, we isolated BMMSCs and UCMSCs from inbred Wuzhishan miniature pigs and generated the first global DNA methylation and gene expression profiles of porcine MSCs. The results showed that the osteogenic and adipogenic differentiation ability of porcine BMMSCs is stronger than that of UCMSCs. Stem cell surface marker CD90 were positively detected in both BMMSCs and UCMSCs. 587 genes were differentially methylated (280 hypermethylated and 307 hypomethylated) at the promoter regions between BMMSCs and UCMSCs. Meanwhile, 1,979 differentially expressed genes (1,407 up-regulated and 572 down-regulated) were identified between BMMSCs and UCMSCs. Integrative analysis reveals that 120 genes displayed differences in both gene expression and promoter methylation. Gene Ontology enrichment analysis revealed that these differential genes were associated with cell differentiation, cell migration, and immunogenicity properties. Remarkably, skeletal system development related genes were significantly hypomethylated and up-regulated in UCMSCs, while cell cycle genes were significantly higher down-regulated and hypermethylated, implying UCMSCs have higher cell proliferative activity and lower osteogenic differentiation potential than BMMSCs.

Conclusions

Our results indicate that DNA methylation plays an important role in regulating the biological characteristics differences between BMMSCs and UCMSCs. The study might provide a molecular theory basis for the application of porcine MSCs in human.
Genome-wide profiling of microRNAs and prediction of mRNA targets in 17 bovine tissues
Authors: Wang Min , Chamberlain Amanda J , Prowse-Wilkins Claire P , Jagt Christy J Vander , Hancock Timothy P , Pryce Jennie E , Cocks Benjamin G , Goddard Michael E , Hayes Benjamin J 
Published: May 2019

Abstract
Background
MicroRNAs regulate many eukaryotic biological processes in a temporal- and spatial-specific manner. Yet in cattle it is not fully known which microRNAs are expressed in each tissue, which genes they regulate, or which sites a given microRNA bind to within messenger RNAs (mRNAs). An improved annotation of tissue-specific microRNA network may in the future assist with the identification of causal variants affecting complex traits.
Results
We report findings from analysing short RNA sequence from 17 tissues from a single lactating dairy cow. Using miRDeep2, we identified 699 expressed mature microRNAs. Using TargetScan, known (60%) and novel (40%) microRNAs were predicted to interact with 780,481 sites in bovine mRNAs homologous with human. Putative interactions between microRNA families and targets were significantly enriched for interactions from previous experimental and computational identification. Characterizing features of microRNAs and targets, we showed that (1) mature microRNAs derived from different arms of the same precursor targeted different genes in different tissues; (2) miRNA target sites preferentially occurred within gene regions undergoing active histone modification; (3) variants within microRNAs and targets had lower allele frequencies than variants across the genome, as identified from 65 million whole genome sequence variants; (4) no significant correlation was found between the abundance of microRNAs and mRNAs differentially expressed in the same tissue; (5) microRNAs and target sites weren’t significantly associated with allelic imbalance of gene targets.
Conclusion
This study contributes to the goals of Functional Annotation of Animal Genomes consortium to improve the annotation of genomes of domestic animals.
Preimplantation genetic testing for balanced complex chromosomal rearrangement carriers by comprehensive chromosome screening
Authors: Li Gang , Shi Weiyi , Niu Wenbin , Xu Jiawei , Guo Yihong , Su Yingchun , Sun Yingpu 
Published: May 2019

Abstract
Background: Balanced complex rearrangements (BCCRs) are balanced chromosomal structural aberrations that involve two or more chromosomes and at least three breakpoints. It is very rare in the population. Whether the couple of BCCRs benefit from preimplantation genetic testing (PGT) need to be further explored. Here, we reported the outcome of PGT in BCCRs carriers.
Results: A total of 141 oocytes were retrieved from 7 couples within 10 PGT cycles, including 116 mature oocytes (MII), and 94 (81.03%) oocytes normally fertilized after intracytoplasmic sperm injection (ICSI). Then, 47 embryos were biopsied, including 8 embryos at the cleavage stage and 39 (41.49%) blastocysts. After comprehensive chromosome analysis, the balanced or normal embryo rate was 11.36% (5), the abnormal embryo rate was 88.63% (39), and 3 failed to amplify. Among them, the balanced or normal embryo rate was 33.33% (3) and the abnormal embryo rate was 66.67% (6) in the three-way rearrangements. The balanced or normal embryo rate was 5.6% (1) and the abnormal embryo rate was 94.4% (17) in double two-way translocations. The balanced or normal embryo rate was 5.9% (1) in exceptional CCRs, and the abnormal embryo rate was 94.1% (16). There were no significant differences among the three groups (P=0.11). In the 10 PGT cycles, there were 7 cycles in which no embryo could be transplanted and 3 cycles in which balanced or normal embryos underwent frozen-thawed embryo transplantation. One of the 3 cycles was clinically pregnant, and the prenatal diagnosis of amniocytes using G-band and SNP array at 16 weeks of gestation was 46, XN, and a boy was born alive and healthy.
Conclusions: BCCR carriers have a high rate of obtaining abnormal embryos, but they can also have healthy offspring. For BCCR carriers with fertility needs, PGT is recommended to have related offspring, or they can choose sperm donor or ovum donation-assisted reproduction.
Lack of defense systems drives Enterococcus easily evolved into lysogens
Authors: Han Shengyi , Zhou JianHua , Ma Lina , Ma Chengxiu , Zeng Qiaoying , Li Xuerui 
Published: May 2019

Abstract
Background: Enterococcus are important opportunistic pathogens that readily acquire foreign genes and could be easily lysogenized by phages. But no comparative genomic analysis of Enterococcus prophages had been undertaken to date. The prophage distribution, potential contribution and the relationship with Enterococcus defensive system remain unclear.
Result: This study presents a comparative analysis of 563 putative prophages identified in 107 chromosomes and 301 plasmids of Enterococcus. Our result suggested that lysogens are highly prevalent in Enterococcus and Enterococcus genomes have more prophages than other bacteria, the number of prophages are related with strains pathogenicity, groups and isolated regions, and the prophages distribution present phylogeographic pattern. By analyzing the prophages characteristic, it is found that prophages can be divided into many clusters, but most of prophages have distant genetic relationship with sequenced phages and remain unreported; Prophages integrated into chromosomes and plasmids have different evolutionary origins, and show different genomes size, GC% and genes characteristic. It should be noted that all antibiotic resistance genes are carried by plasmids prophages and E. faecium plasmid prophages play important roles in transmission of vancomycin resistance genes through plasmid conjugation transfer and phages transduction. By investigating and statistical analyzing the relationship between major defend systems and the number of prophages, it indicated that R-M system often absent in Enterococcus, orphan CRISPR array prevalent in most of Enterococcus, and the presence of CRISPR-spacers and the absence of prophages in lysogen is inversely related.
Conclusion: To our knowledge, this is the first systematic analysis of Enterococcus prophages distribution, potential contribution and phylogeny, and elucidate the relationship between defense system and lysogeny in Enterococcus. This information helps to understand how prophages affect its hosts diversity, fitness and evolution.
N6-methyladenosine modification modulate in the heat stress of sheep (Ovis aries)
Authors: Lu Zengkui , Wang Huihua , Ma Youji , Chu Mingxing , Quan Kai , Liu Yongbin , Wang Yuqin , Zhang Liping , Li Qing , Liu Enmin , Ma Lin , Jin Meilin , Fei Xiaojuan , Wei Caihong 
Published: May 2019

Abstract
Background: Intensive and large-scale development of the sheep industry and increases in global temperature are increasingly exposing sheep to heat stress. N6-methyladenosine (m6A) mRNA methylation varies in response to stress, and can link external stress with complex transcriptional and post-transcriptional processes. However, no m6A mRNA methylation map has been obtained for sheep, nor is it known what effect this has on regulating heat stress in sheep. Results: A total of 8,306 and 12,958 m6A peaks were detected in heat stress and control groups, respectively, with 2,697 and 5,494 genes associated with each. Peaks were mainly enriched in coding regions and near stop codons with classical RRACH motifs. Methylation levels of heat stress and control sheep were higher near stop codons, although methylation was significantly lower in heat stress sheep. GO revealed that differential m6A-containing genes were mainly enriched in the nucleus and were involved in several stress responses and substance metabolism processes. KEGG pathway analysis found that differential m6A-containing genes were significantly enriched in Rap1, FoxO, MAPK, and other signaling pathways of the stress response, and TGF-beta, AMPK, Wnt, and other signaling pathways involved in fat metabolism. These m6A-modified genes were moderately expressed in both heat stress and control sheep, and the enrichment of m6A modification was significantly negatively correlated with gene expression. Conclusions: Our results showed that m6A mRNA methylation modifications regulate heat stress in sheep, and it also provided a new way for the study of animal response to heat stress.