bluuebunny/crossref_metadata_2025_split huggingface dataset:
An in vivo confocal, prospective, masked, 36 months study on glaucoma patients medically treated with preservative-free or preserved monotherapy
Authors: Rossi Gemma Caterina Maria , Scudeller Luigia , Lumini Chiara , Mirabile Alessandra Venera , Picasso Erica , Bettio Federica , Pasinetti Gian Maria , Bianchi Paolo Emilio 
Published: March 2019

AbstractThe aim of this study was to evaluate the in vivo effects at 3 years of preservative-free tafluprost on corneal health. It was a prospective, masked, study on consecutive patients with a new prescription of preservative-free (PF) tafluprost (naïve-N or switched-S, 44 and 14 patients), and preserved (P) bimatoprost 0.003% or travoprost 0.004% (P-group, 35 patients). A complete ophthalmic examination and an in vivo corneal confocal microscopy evaluation were performed at baseline and every 6 months for 3 years. Ninety-three patients were enrolled, clinical parameters were similar in the groups at baseline, apart from intraocular pressure (IOP) which was lower in the S-group (p = 0.012). Both at baseline and over time, confocal microscopy parameters had different trends. At baseline, keratocyte activation was similar in the three groups (p = 0.43) but over the next months naïve patients treated with PF-tafluprost presented a significant (p = 0.004) reduction in keratocyte activation. Sub-basal nerves tended to increase in patients switched to PF-tafluprost (p = 0.07) while were stable in the other two groups (p = 0.11 in PF and 0.40 in P group). Grade of tortuosity was stable over time in the three groups. Beading-like formations were stable over time for the P- and the PF-group, while significantly increased in the S-group (p = 0.027). Endothelial density values were statistically different at baseline (p = 0.007), they decreased both in PF-group and in S-group (p = 0.048 and 0.001, respectively), while increased in P-group (p = 0.006). Our study is the first to show that a PF-tafluprost formulation does not significantly alter the corneal structures as examined by confocal microscopy after 36 months of topical daily therapy, while improving corneal alterations due to chronic preserved therapies.
Genomic analysis of carbon dioxide sequestering bacterium for exopolysaccharides production
Authors: Kumar Manish , Kumar Madan , Pandey Ashok , Thakur Indu Shekhar 
Published: March 2019

AbstractIn the present study, genomic analysis of a previously reported carbon dioxide (CO2) sequestering bacterium Serratia sp. ISTD04 was performed along with exopolysaccharide (EPS) production. Genomic analysis identified key and accessory enzymes responsible for CO2 sequestration. EPS synthesis genes were discovered in the genome and identified 8 putative clusters responsible for lipopolysaccharide, stewartan, emulsan, polysaccharide B, capsular polysaccharide and fatty acid-saccharide production. The production of EPS was found to be 0.88 ± 0.08, 1.25 ± 0.13 and 1.44 ± 0.10 g L−1 on glucose, bicarbonate (NaHCO3) and NaHCO3 plus glucose respectively at pH 7.8. After optimizing process parameters, the EPS production increased more than 3 folds. The morphology of strain and elemental composition of EPS was characterized by SEM-EDX. The functional groups, monomer composition, linkage analysis and structure of purified EPS was characterized by FTIR, GC-MS and 1H and 13C NMR. Glucose, galactose, mannose and glucosamine are the monomers detected in the EPS. EPS was further applied for bioflocculation (kaolin test) and dye removal. The EPS showed 68% ± 0.9 flocculating activity and decolorized cationic dye acridine orange (80%) and crystal violet (95%). The results highlight CO2 sequestration and EPS production potential of Serratia sp. ISTD04 that can be harnessed in future.
High resolution annual average air pollution concentration maps for the Netherlands
Authors: Schmitz Oliver , Beelen Rob , Strak Maciej , Hoek Gerard , Soenario Ivan , Brunekreef Bert , Vaartjes Ilonca , Dijst Martin J. , Grobbee Diederick E. , Karssenberg Derek 
Published: March 2019

AbstractLong-term exposure to air pollution is considered a major public health concern and has been related to overall mortality and various diseases such as respiratory and cardiovascular disease. Due to the spatial variability of air pollution concentrations, assessment of individual exposure to air pollution requires spatial datasets at high resolution. Combining detailed air pollution maps with personal mobility and activity patterns allows for an improved exposure assessment. We present high-resolution datasets for the Netherlands providing average ambient air pollution concentration values for the year 2009 for NO2, NOx, PM2.5, PM2.5absorbance and PM10. The raster datasets on 5×5 m grid cover the entire Netherlands and were calculated using the land use regression models originating from the European Study of Cohorts for Air Pollution Effects (ESCAPE) project. Additional datasets with nationwide and regional measurements were used to evaluate the generated concentration maps. The presented datasets allow for spatial aggregations on different scales, nationwide individual exposure assessment, and the integration of activity patterns in the exposure estimation of individuals.
Peroral endoscopic myotomy versus pneumatic dilation – result from a retrospective study with 1-year follow-up
Authors: Zheng Zhongqing , Zhao Chunshan , Su Shuai , Fan Xiaofei , Zhao Wei , Wang Bin , Jin Hong , Zhang Lili , Wang Tao , Wang Bangmao 
Published: March 2019

Abstract
Background and aims On the basis of lesser rates of major adverse events and a short-term efficacy as Heller’s myotomy, there is a growing enthusiasm in favor of peroral endoscopic myotomy (POEM), whereas study comparing POEM and pneumatic dilatation (PD) is quite rare. The aim of this study was to evaluate the efficacy of POEM and PD in Chinese achalasia patients in a retrospectively designed study.
Methods Patients with achalasia, who underwent either PD (n = 26) or POEM (n = 40) were retrospectively recruited from September 2010 through March 2016 at a single tertiary center. During the 1-year follow-up, clinical outcome and functional data of lower esophageal sphincter (LES) were recruited. Clinical symptoms were assessed by use of the Eckardt score. The primary outcome was therapeutic success (Eckardt score ≤ 3). Functional data of LES (4-second integrated relaxation pressure [4s-IRP], LES relax rate, and LESP) at baseline and 1 month after treatment were also evaluated. Data was analyzed by SPSS 13.0 version using a significance level of p < 0.05.
Results The success rates were 24/26 (92.31 %), 25/26 (96.15 %), and 24/26 (92.31 %), respectively, with POEM, as compared with 35/40 (87.50 %), 29/40 (72.50 %), and 23/40 (57.50 %), respectively, with PD, 1 month, 3 months, and 1 year after treatment. Statistically significant difference was observed between the 2 therapies (at 3 months, Fisher’s exact test, p = 0.01; at 1 year, Fisher’s exact test, p < 0.0001). Compared with PD, the Eckardt score was lower with POEM 1 month, 3 months, and 1 year after treatment. More patients in POEM group reported gastroesophageal reflux symptoms (after 3 months 7/26 (26.92 %) vs. 2/40 (5.00 %), Fisher’s exact test, p = 0.01; after 1 year 6/26 (19.23 %) vs. 1/35 (2.86 %), Fisher’s exact test, p = 0.02). The postoperative 4s-IRP and LESP were both lower with POEM than with PD, respectively. Type I achalasia had a better response with POEM than with PD.
Conclusion In this retrospective analysis with 1-year follow-up, POEM presents with a higher success rate and more reflux symptoms compared with PD. Change on LES function after treatment may explain the outcome in part. Type I achalasia may respond better to therapies compared with type II.
Severe ileocecal inflammatory syndrome in adult patients with cystic fibrosis
Authors: Henker Robert , Oltmanns Annett , Wald Alexandra , Tuennemann Jan , Opitz Sabine , Hoffmeister Albrecht , Wirtz Hubert , Mössner Joachim , Jansen-Winkeln Boris , Karlas Thomas 
Published: March 2019

AbstractThe relevance of gastrointestinal manifestations of cystic fibrosis (CF) is increasing due to an improved life expectancy. We report on 2 adult patients with prior lung transplantation who presented with a severe inflammatory disorder of the ileocecal region. One patient underwent ileocecal resection; the second patient died after emergency surgery for intestinal perforation. Both cases did not show typical signs of CF-related distal intestinal obstruction syndrome or extensive fibrosing colonopathy. However, the clinical and histopathological findings revealed CF-induced inflammatory alterations of the intestinal mucosa. Thus, these cases illustrate a further CF-related bowel disorder, which can be especially relevant in long-term CF survivors.
Dermatitis solaris unter kombinierter Creme-PUVA/UVB-Phototherapie
Authors: Elsner P. , Meyer J. 
Published: March 2019

ZusammenfassungBei einem Patienten mit einem chronischen Ekzem kam es unter der Kombination einer Creme-PUVA-Therapie mit einer zusätzlichen lokalen UVB-Behandlung mittels Excimer 308-Therapiegerät zum Auftreten einer schweren, schmerzhaften und langanhaltenden Dermatitis solaris II. Grades. Nach Facharztstandard ist die Kombination einer Creme-PUVA-Therapie mit am selben Tag durchgeführter UVA-Dosissteigerung sowie in kurzer Abfolge zusätzlicher Behandlung mittels monochromatischem UVB (Excimer 308) ohne vorherige Feldbehandlung zur Bestimmung der individuellen Verträglichkeit als Behandlungsfehler zu bewerten. Gerade bei neuen Therapieverfahren oder ihrer Kombination mit bewährten Verfahren ist von einem erhöhten Nebenwirkungspotenzial auszugehen. Dieses sollte durch geeignete Vorsichtsmaßnahmen minimiert und vorab im Rahmen der ärztlichen Aufklärung gegenüber dem Patienten kommuniziert werden, um eine rechtswirksame Einwilligung zu der Behandlung sicherzustellen.
Reference Intervals for Thyroid Hormones During the First Trimester
of Gestation: A Report from an Area with a Sufficient Iodine
Level
Authors: Kianpour Maryam , Aminorroaya Ashraf , Amini Massoud , Feizi Awat , Janghorbani Mohsen , Shokri Saeideh , Yamini Sima Aminorroaya , Farghadani Maryam , Hekmatnia Ali , Gharib Hossien 
Published: March 2019

AbstractThe physiological changes during pregnancy modulate the endocrine system.
Therefore, both the American and the European thyroid associations recommend
the use of local trimester-specific reference intervals. The purpose of this
study was to establish the first trimester reference intervals for thyroid
function tests in the central area of Iran. We examined 436 pregnant women
in their first trimester of pregnancy, and 444 non-pregnant women in a cross
sectional study. Serum levels of thyroid stimulating hormone (TSH), free
thyroxin (FT4), free triiodothyronine (FT3), thyroid
peroxidase antibody, urinary iodine concentration (UIC), and thyroid volume
were measured for all subjects. The first trimester-specific reference
intervals (2.5th–97.5th percentile) were determined for 185 pregnant
women and 256 non-pregnant women with negative TPOAb, adequate iodine level
(UIC≥150 μg/l in pregnant and
UIC≥100 μg/l in non-pregnant women), and
normal thyroid examination. We calculated multiples of the median (MoM) for
TFTs to normalize the obtained data. The first trimester-specific reference
intervals of serum TSH, FT4, and FT3 for pregnant
women were 0.20–4.60 mIU/l,
9.0–18.02 pmol/l, and
3.40–5.64 pmol/l, respectively, while the
corresponding figures for non-pregnant women were
0.59–5.60 mIU/l,
9.52–19.30 pmol/l, and
3.70–5.55 pmol/l, respectively. The first and 99th
percentile MoM of TSH in pregnant women in their first-trimester was
0.026–4.61. The local normal reference ranges for the first
trimester of pregnancy in central region of Iran were different from the
ranges suggested by the ATA.
PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)—Rationale and Design
Authors: O'Brien Sarah , Li Danshi , Mitchell Lesley , Hess Thomas , Zee Pamela , Yee Donald , Newburger Jane , Sung Lillian , Rodriguez Vilmarie 
Published: March 2019

AbstractVenous thromboembolic (VTE) complications in children and adolescents with acute lymphoblastic leukaemia (ALL) and T or B cell lymphoblastic lymphoma (T/B cell LL) can result not only in life-threatening acute complications but also contribute to significant long-term sequelae. The PREVAPIX-ALL study is an open-label randomized controlled study comparing outcomes of treatment with prophylactic dose apixaban versus no anticoagulation (standard of care) in children and adolescents with ALL and T/B cell LL receiving standard induction chemotherapy with asparaginase and the presence of a central venous access device. On day 29 of induction, all patients undergo screening imaging with duplex ultrasonography and echocardiography. The primary efficacy endpoint of the study is a composite of symptomatic and asymptomatic VTE that includes deep vein thrombosis, pulmonary embolism, cerebral sinovenous thrombosis or VTE-related death. The primary safety outcome is major bleeding. Secondary outcomes are central line-associated infections, patency and line replacement, superficial thrombosis, arterial events and death. A planned sample size of 500 randomized paediatric patients enrolled over a period of 5 years is based on the estimation of VTE rates of 20 and 10% in the standard of care and apixaban groups, respectively. An optional biomarker study in 150 patients will examine predictors of increased VTE risk and study in vivo anticoagulant effects of apixaban in children by measuring specific biomarkers in the haemostatic system and inflammatory pathway. This study will provide valuable information for the safety and efficacy of apixaban in VTE prevention during induction in paediatric ALL.
The language of numbers
Authors: Whitehouse Marlies 
Published: March 2019

Abstract
Wider parts of society-at-large are not fluent in the language of numbers, and financial literacy in particular is
low in many countries (OECD, 2014). This paper shows how research on financial
communication with and for practitioners (Cameron, Frazer, Rampton, & Richardson,
1992, p. 22) can foster intra-lingual translation in the financial sector, which increases financial texts’
communicative potential and finally enables laypersons to better understand the language of numbers. Such an increased
understanding allows individuals to set up investment plans for their current and future wealth and, for example, make informed
decisions about their pension plans. By doing so, financial crises on the individual, organizational, and societal level can be
avoided, which benefits social welfare and society-at-large.
Transdisciplinary Action Research (TDA) offers a framework and procedures to approach such goals through close
collaboration of scholars and practitioners throughout research projects. Following TDA core concepts, a cyclic process of
research and development has been established in the last two decades (e.g. Perrin, this volume; Whitehouse, 2014). Whereas applied linguists involved aimed at better understanding practices of writing
and intra-lingual translation at the interface of technical and everyday language, stakeholders from the financial industry wanted
to improve their communication. The representatives of society-at-large, finally, were interested in contributing to sustainably
increasing financial literacy.
In the first part of the present paper, I sketch the suitability of transdisciplinarity in general and TDA in
particular in financial communication (Section 1). Then I define the key concepts of
intra-lingual translation, communicative potential, and financial literacy (Section 2). Next,
I outline the data corpus and explain how TDA was applied in a series of research projects (Section 3). The presented results on a macro-level shed light on the financial analysts’ situation and practices in
their multilingual workplace: the findings on the micro-level suggest that financial analysts’ texts pose a risk of partial
communicative failure (Section 4). The article concludes by indicating empirically based
measures to develop financial literacy, intra-lingual translation across stakeholders and texts’ communicative potential in
finance (Section 5).
Instrumented platform for assessment of isometric hand muscles contractions
Authors: Malešević Nebojša , Andersson Gert , Björkman Anders , Controzzi Marco , Cipriani Christian , Antfolk Christian 
Published: March 2019

Abstract
Measurement of forces exerted by a human hand while performing common gestures is a highly valuable task for assessment of neurorehabilitation and neurological disorders, but also, for control of movement that could be directly transferred to assistive devices. Even though accurate and selective multi-joint measurement of hand forces is desirable in both clinical and research applications there is no commercially available device able to perform such measurements. Moreover, the custom-made systems used in research commonly impose limitations, such as availability of only single, predefined hand aperture. Furthermore, there is no consensus on design requirements for custom made measurement systems that would enable comparison of results obtained during research or clinical hand function studies. In an attempt to provide a possible solution for a device capable of multi-joint hand forces measurement and disseminate it to the research community, this paper presents the mechanical and electronic design of an instrumented platform for assessment of isometric hand muscles contractions. Some of the key features related to the developed system are: flexibility in placing the hand/fingers, fast and easy hand fitting, adjustability to different lengths, circumferences and postures of the digits, and the possibility to register individual bidirectional forces from the digits and the wrist. The accuracy of isometric force measurements was evaluated in a controlled test with the reference high accuracy force gauge device during which the developed system showed high linearity (R
2  =  0.9999). As the more realistic test, the device was evaluated when force was applied to individual sensors but also during the intramuscular electromyography (iEMG) study. The data gathered during the iEMG measurements was thoroughly assessed to obtain three appropriate metrics; the first estimating crosstalk between individual force sensors; the second evaluating agreement between measured forces and forces estimated through iEMG; and the third providing qualitative evaluation of hand force in respect to activations of individual muscle units. The results of these analyses performed on multiple joint forces show agreement with previously published results, but with the difference that in that case, the measurement was performed with a single degree of freedom device.
RETRACTED: Research on Transmission Functions of Foreign Language and Chinese Medicine Culture under the Background of “Big Data”
Authors: Ying Liu , Zhanyi He 
Published: March 2019

Abstract
In order to solve the problem of learning resource description in big data environment, this paper proposes a learning resource description system based on metamodel, that is, to establish a set of metadata model that is not only in line with the standards of learning resource description, but also has extensibility. By referring or mapping to the element set of the common metamodel, the elements of the metadata model of various resources are obtained to achieve the compatibility between different metadata models. This paper combines the learning resource model in the context of big data, and analyses the transmission functions of foreign language and Chinese medicine culture, including communication of language, communication of Chinese medicine culture, communication of Chinese medicine trade and communication of Chinese medicine financing.
RETRACTED: Research on Citizen Participation in the Implementation of Public Policy in Big Data Age※
Authors: Xiaodong Liao , Xiaoping Liu , Feng Feng 
Published: March 2019

Abstract
The advent of the big data age provides an effective tool for citizens who can better participate in the implementation of public policies. Citizens’ participation in the process of public policy implementation is conducive to the better realization of the objectives of the subjects of public policy implementation, to the implementation of the “bottom-up” public policy model, to the maximization of public interest and to the citizens’ needs to adapt to public policies. However, the enthusiasm and degree of citizen’s participation in the implementation of public policy are relatively low, because of some subjective and objective constraints in the process. We should cultivate citizens’ ability and consciousness to participate in public policies, establish a two-way interactive mechanism between the government and citizens, and strengthen the information disclosure in the process of public policy implementation.
Propensity Score Analysis of Artesunate Versus Quinine for Severe Imported Plasmodium falciparum Malaria in France
Authors: El Ket Nermine , Kendjo Eric , Thellier Marc , Assoumou Lambert , Potard Valérie , Taieb Aida , Tantaoui Ilhame , Caumes Eric , Piarroux Renaud , Roussel Camille , Buffet Pierre , Costagliola Dominique , Jauréguiberry Stéphane 
Published: March 2019

Abstract

Background
Little is known on the use of artesunate compared with quinine for the treatment of imported malaria cases in nonendemic countries with a high level of care. Therefore, we compared the 2 treatments in terms of mortality and hospital and intensive care unit (ICU) discharge rates.

Methods
We analyzed the cohort of all severe imported malaria patients reported to the French National Reference Center from 2011 to 2017. After controlling for differences between quinine- and artesunate-treated individuals using the inverse probability of treatment weighting method, 28-day mortality rate was compared between the groups as well as hospital and ICU discharge rates using Kaplan–Meier estimation and weighted Cox proportional hazard models.

Results
Overall, 1544 patients were enrolled. Fifty patients died, 18 in the quinine group (n = 460) and 32 in the artesunate group (n = 1084), corresponding to death rates of 3.9% and 2.9%, respectively. No difference was evident between quinine and artesunate either in mortality or in hospital discharge rate, with hazard ratios (HRs) of 1.03 (95% confidence interval [CI], 0.47–2.25) and 1.12 (95% CI, 0.94–1.34), respectively. Artesunate was associated with a faster ICU discharge rate (HR, 1.18. 95% CI, 1.02–1.36).

Conclusions
In a country with a high level of care, artesunate was associated with a shorter length of stay in the ICU, which supports the actual therapeutic transition; however, no difference was found in terms of mortality or in hospital discharge rates between artesunate- and quinine-treated patients.