bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of Adverse Reactions to Parenteral Thiamine in the Treatment of Wernicke’s Encephalopathy, and Recommendations
Authors: Thomson Allan , Guerrini Irene , Marshall Elizabeth Jane 
Published: January 2019

Abstract

Aim
To offer an estimate of the incidence of anaphylactic reactions to parenteral products containing thiamine used in the treatment of Wernicke’s encephalopathy (WE) and make recommendations.

Method
Review of previously released data on some older products and parenteral thiamine use in some other countries; analysis of sales and adverse incident data on anaphylaxis for a contemporary parenteral product used in the UK, Pabrinex.

Results
It was difficult to estimate the incidence of related anaphylactic reactions to Pabrinex in the UK because the number of doses given is unknown. Sales data are only an approximation to doses given because for products with a limited shelf life not all product sold is administered. However, available data indicate that there have been 10 anaphylactic reactions to Pabrinex from between 5,431,235–6,651,947 patient-days (14,880–16,080 years) of treatment.

Conclusion
It is reasonable to assume that the risk of anaphylaxis is low, and lower than for many other drugs. The risk-benefit ratio for administration is favourable given the potential severity of brain damage in Wernicke–Korsakoff (WK) syndrome. There is a need for international agreement on the reporting of anaphylaxis and on the optimum thiamine therapy for the treatment of WK syndrome. We make recommendations on how this might be achieved.
Estimating the importance of maize root hairs in low phosphorus conditions and under drought
Authors: Klamer Florian , Vogel Florian , Li Xuelian , Bremer Hinrich , Neumann Günter , Neuhäuser Benjamin , Hochholdinger Frank , Ludewig Uwe 
Published: January 2019

Abstract

Background and Aims
Root hairs are single-cell extensions of the epidermis that face into the soil and increase the root–soil contact surface. Root hairs enlarge the rhizosphere radially and are very important for taking up water and sparingly soluble nutrients, such as the poorly soil-mobile phosphate. In order to quantify the importance of root hairs for maize, a mutant and the corresponding wild type were compared.

Methods
The rth2 maize mutant with very short root hairs was assayed for growth and phosphorus (P) acquisition in a slightly alkaline soil with low P and limited water supply in the absence of mycorrhization and with ample P supply.

Key Results
Root and shoot growth was additively impaired under P deficiency and drought. Internal P concentrations declined with reduced water and P supply, whereas micronutrients (iron, zinc) were little affected. The very short root hairs in rth2 did not affect internal P concentrations, but the P content of juvenile plants was halved under combined stress. The rth2 plants had more fine roots and increased specific root length, but P mobilization traits (root organic carbon and phosphatase exudation) differed little.

Conclusions
The results confirm the importance of root hairs for maize P uptake and content, but not for internal P concentrations. Furthermore, the performance of root hair mutants may be biased by secondary effects, such as altered root growth.
Neurofeedback Training of Gamma Oscillations in Monkey Primary Visual Cortex
Authors: Chauvière L , Singer W 
Published: January 2019

Abstract
In humans, neurofeedback (NFB) training has been used extensively and successfully to manipulate brain activity. Feedback signals were derived from EEG, fMRI, MEG, and intracranial recordings and modifications were obtained of the BOLD signal, of the power of oscillatory activity in distinct frequency bands and of single unit activity. The purpose of the present study was to examine whether neuronal activity could also be controlled by NFB in early sensory cortices whose activity is thought to be influenced mainly by sensory input rather than volitional control. We trained 2 macaque monkeys to enhance narrow band gamma oscillations in the primary visual cortex by providing them with an acoustic signal that reflected the power of gamma oscillations in a preselected band and rewarding increases of the feedback signal. Oscillations were assessed from local field potentials recorded with chronically implanted microelectrodes. Both monkeys succeeded to raise gamma activity in the absence of visual stimulation in the selected frequency band and at the site from which the NFB signal was derived. This suggests that top–down signals are not confined to just modulate stimulus induced responses but can actually drive or facilitate the gamma generating microcircuits even in a primary sensory area.
Kidney transplantation: an attractive and cost-effective alternative for older patients? A cost–utility study
Authors: Heldal Kristian , Midtvedt Karsten , Lønning Kjersti , Iversen Tor , Hernæs Kjersti Helene , Tsarpali Vasiliki , Reisæter Anna Varberg , Bernklev Tomm 
Published: January 2019

AbstractBackgroundIn the elderly, kidney transplantation is associated with increased survival and improved health-related quality of life compared with dialysis treatment. We aimed to study the short-term health economic effects of transplantation in a population of elderly kidney transplant candidates.MethodsSelf-perceived health, quality-adjusted life years (QALYs) and costs were evaluated and compared 1 year before and 1 year after kidney transplantation in patients included in a single-centre prospective study of 289 transplant candidates ≥65 years of age.ResultsSelf-perceived health and QALYs both significantly improved after transplantation. At 1 year, the costs per QALY were substantially higher for transplantation (€88 100 versus €76 495), but preliminary analyses suggest a favourable long-term health economic effect.ConclusionsKidney transplantation in older kidney transplant recipients is associated with improved health but also with increased costs the first year after engraftment when compared with remaining on the waiting list. Any long-term cost-effectiveness needs to be confirmed in studies with longer observation times.
High-risk human papilloma virus infection and cervical neoplasm in female inflammatory bowel disease patients: a cross-sectional study
Authors: Li Miao , Yang Qing-Fan , Cao Qian , Tang Jian , Gao Yu , Zhi Min , Chao Kang , Su Ming-Li , Huang Wei-Min , Yi Yan , Xia Sui-Yan , Huang Ling-Jie , Zhao Yuan , Wang Xiao-Hong , Liu Xiao-Ying , Lin Lin , Hu Pin-Jin , Gao Xiang 
Published: January 2019

Abstract

Background and aim
This cross-sectional study investigated the prevalence and risk factors of high-risk human papilloma virus (HPV) infection, especially types 16 and 18, and cervical neoplasia in female Inflammatory bowel disease (IBD) patients.

Methods
From July 2014 to January 2017, sexually active, female, Chinese IBD patients (21–60 years) and age-matched controls underwent cervical ThinPrep cytology testing (TCT) and high-risk HPV-DNA detection, and completed questionnaires about awareness of cervical cancer and HPV. Cervical dysplasia was categorized as cervical intraepithelial neoplasia (CIN) 1, 2 and 3.

Results
Of 124 IBD patients (30 ulcerative colitis and 94 Crohn’s disease), 17 (13.7%) had high-risk HPV among whom 9 (7.3%) had HPV 16/18 infection and 4 (3.2%) had cervical CIN (3 CIN 3, 1 CIN 1) by pathology. Among 372 controls, 33 (8.9%) had high-risk HPV and only 1 (0.3%) had HPV 16 infection. Cervical TCT detected atypical squamous cells of unknown significance in one control; no control had CIN. The HPV 16/18 infection rate and CIN prevalence were significantly higher in IBD patients than controls (both P < 0.001). The HPV-infection rate was higher in patients administered methotrexate [P = 0.005, odds ratio (95% confidence interval) 4.76 (1.471–15.402)] or more than two immunosuppressants [P = 0.013, odds ratio (95% confidence interval) 3.64 (1.255–10.562)]. Thiopurine, steroid, infliximab and disease behavior/location were not associated with HPV infection. Only 29.3% of patients had undergone cervical-cancer screening. Awareness of HPV infection and HPV-related cervical cancer was poor (28.2%).

Conclusions
Female IBD patients are at increased risk of high-risk HPV infection and cervical neoplasia, which may be associated with immunosuppressants. Education and routine follow-up with HPV-DNA testing and TCT are recommended, especially in female Chinese IBD patients.
A Multisite Case Study of Caregiver Advise, Record, Enable Act Implementation
Authors: Leighton Cassandra , Fields Beth , Rodakowski Juleen L , Feiler Connie , Hawk Mary , Bellon Johanna E , James A Everette 
Published: January 2019

Abstract

Background and Objectives
The Commonwealth of Pennsylvania passed the Caregiver Advise, Record, Enable (CARE) Act on April 20, 2016. We designed a study to explore early implementation at a large, integrated delivery financing system. Our goal was to assess the effects of system-level decisions on unit implementation and the incorporation of the CARE Act’s three components into routine care delivery.

Research Design and Methods
We conducted a multisite, ethnographic case study at three different hospitals’ medical–surgical units. We conducted observations and semi-structured interview to understand the implementation process and the approach to caregiver identification, notification, and education. We used thematic analysis to code interviews and observations and linked findings to the Promoting Action on Research Implementation in Health Services framework.

Results
Organizational context and electronic health record capability were instrumental to the CARE Act implementation and integration into workflow. The implementation team used a decentralized strategy and a variety of communication modes, relying on local hospital units to train staff and make the changes. We found that the system facilitated the CARE Act implementation by placing emphasis on the documentation and charting to demonstrate compliance with the legal requirements.

Discussion and Implications
General acute hospitals will be making or have made similar decisions on how to operationalize the regulatory components and demonstrate compliance with the CARE Act. This study can help to inform others as they design and improve their compliance and implementation strategies.
Integrable Systems of Double Ramification Type
Authors: Buryak Alexandr , Dubrovin Boris , Guéré Jérémy , Rossi Paolo 
Published: January 2019

AbstractIn this paper we study various aspects of the double ramification (DR) hierarchy, introduced by the 1st author, and its quantization. We extend the notion of tau-symmetry to quantum integrable hierarchies and prove that the quantum DR hierarchy enjoys this property. We determine explicitly the genus $1$ quantum correction and, as an application, compute completely the quantization of the $3$- and $4$-KdV hierarchies (the DR hierarchies for Witten’s $3$- and $4$-spin theories). We then focus on the recursion relation satisfied by the DR Hamiltonian densities and, abstracting from its geometric origin, we use it to characterize and construct a new family of quantum and classical integrable systems that we call of DR type, as they satisfy all of the main properties of the DR hierarchy. In the 2nd part, we obtain new insight towards the Miura equivalence conjecture between the DR and Dubrovin-Zhang (DZ) hierarchies, via a geometric interpretation of the correlators forming the DR tau-function. We then show that the candidate Miura transformation between the DR and DZ hierarchies (which we uniquely identified in our previous paper) indeed turns the DZ Poisson structure into the standard form. Eventually, we focus on integrable hierarchies associated with rank-$1$ cohomological field theories and their deformations, and we prove the DR/DZ equivalence conjecture up to genus $5$ in this context.
“Verses of My Owne Making”: Literacy, Work, and Social Identity in Early Modern England
Authors: Waddell Brodie 
Published: January 2019

Abstract
Reading and writing became widespread in England over the course of the early modern period, with literacy expanding alongside rapid commercial development and growing economic inequality. This article shows how tradesmen and others of similar rank used reading and writing to create a powerful identity that cut across some of the sharpening divisions in wealth from the late sixteenth to the early eighteenth centuries. Growing numbers of economically precarious “middling” men and women took advantage of the spread of literacy to construct social roles for themselves based on godly work, vocational knowledge, and occupational fraternity. This analysis begins with the uniquely voluminous collection of notebooks filled by an Essex tradesman named Joseph Bufton (1651–1718). Drawing on his notebooks together with other examples of non-elite writing and cheap print, it reveals a broad literary culture that was emerging in provincial towns at this time. Through this, it connects the historiography of social structure and economic change to the growing research on non-elite literacy and life-writing. Taken together, these findings suggest that the existing narrative of early modern “social polarization” should be revisited. Rather than consistently reinforcing the deep economic divisions between workers and masters, literacy could often serve as a tool for crafting a shared identity that could encompass a whole trade.
Unmet Menstrual Hygiene Needs Among Low-Income Women
Authors: Sebert Kuhlmann Anne , Peters Bergquist Eleanor , Danjoint Djenie , Wall L. Lewis 
Published: January 2019

OBJECTIVE:
To assess the menstrual hygiene needs of low-income women in St. Louis, Missouri.

METHODS:
Using an exploratory, cross-sectional design, women 18 years of age and older were recruited from a purposive sample of 10 not-for-profit community organizations that serve low-income women in St. Louis. From July 2017 to March 2018, 183 interviewer-administered surveys and three focus group discussions were conducted. Surveys and focus groups identified where and how women access menstrual hygiene products and what they do when they cannot afford to buy them. Using a snowball sampling strategy, 18 community organizations were also surveyed electronically to assess what services and supplies they provide for menstrual hygiene.

RESULTS:
All women invited to participate in the interviews and the focus groups agreed to do so. Nearly two thirds (64%) of women were unable to afford needed menstrual hygiene supplies during the previous year. Approximately one fifth of women (21%) experienced this monthly. Many women make do with cloth, rags, tissues, or toilet paper; some even use children’s diapers or paper towels taken from public bathrooms. Nearly half of women (46%) could not afford to buy both food and menstrual hygiene products during the past year. There was no difference in menstrual hygiene needs by age. Two thirds of organizations indicated that menstrual hygiene was a need of their clients. Thirteen provide menstrual hygiene supplies to their clients; two provide menstrual hygiene education.

CONCLUSION:
Menstrual hygiene supplies are a basic necessity that many low-income women lack. We document the extent to which low-income women in a major metropolitan area in the United States are unable to afford these basic necessities and what they do to cope. Women’s health care providers should advocate for improved access to menstrual hygiene supplies for low-income females across the United States.
Short-Term Effects and Long-Term Cost-Effectiveness of Universal Hepatitis C Testing in Prenatal Care
Authors: Tasillo Abriana , Eftekhari Yazdi Golnaz , Nolen Shayla , Schillie Sarah , Vellozzi Claudia , Epstein Rachel , Randall Liisa , Salomon Joshua A. , Linas Benjamin P. 
Published: January 2019

OBJECTIVE:
To estimate the clinical effects and cost-effectiveness of universal prenatal hepatitis C screening, and to calculate potential life expectancy, quality of life, and health care costs associated with universal prenatal hepatitis C screening and linkage to treatment.

METHODS:
Using a stochastic individual-level microsimulation model, we simulated the lifetimes of 250 million pregnant women matched at baseline with the U.S. childbearing population on age, injection drug use behaviors, and hepatitis C virus (HCV) infection status. Modeled outcomes included hepatitis C diagnosis, treatment and cure, lifetime health care costs, quality-adjusted life years (QALY) and incremental cost-effectiveness ratios comparing universal prenatal hepatitis C screening to current practice. We modeled whether neonates exposed to maternal HCV at birth were identified as such.

RESULTS:
Pregnant women with hepatitis C infection lived 1.21 years longer and had 16% lower HCV-attributable mortality with universal prenatal hepatitis C screening, which had an incremental cost-effectiveness ratio of $41,000 per QALY gained compared with current practice. Incremental cost-effectiveness ratios remained below $100,000 per QALY gained in most sensitivity analyses; notable exceptions included incremental cost-effectiveness ratios above $100,000 when assuming mean time to cirrhosis of 70 years, a cost greater than $500,000 per false positive diagnosis, or population HCV infection prevalence below 0.16%. Universal prenatal hepatitis C screening increased identification of neonates exposed to HCV at birth from 44% to 92%.

CONCLUSIONS:
In our model, universal prenatal hepatitis C screening improves health outcomes in women with HCV infection, improves identification of HCV exposure in neonates born at risk, and is cost-effective.
p53, stem cell biology and childhood blastomas
Authors: Oh Lixian , Hafsi Hind , Hainaut Pierre , Ariffin Hany 
Published: January 2019

Purpose of reviewChildhood blastomas, unlike adult cancers, originate from developing organs in which molecular and cellular features exhibit differentiation arrest and embryonic characteristics. Conventional cancer therapies, which rely on the generalized cytotoxic effect on rapidly dividing cells, may damage delicate organs in young children, leading to multiple late effects. Deep understanding of the biology of embryonal cancers is crucial in reshaping the cancer treatment paradigm for children.Recent findingsp53 plays a major physiological role in embryonic development, by controlling cell proliferation, differentiation and responses to cellular stress. Tumor suppressor function of p53 is commonly lost in adult cancers through genetic alterations. However, both somatic and germline p53 mutations are rare in childhood blastomas, suggesting that in these cancers, p53 may be inactivated through other mechanisms than mutation. In this review, we summarize current knowledge about p53 pathway inactivation in childhood blastomas (specifically neuroblastoma, retinoblastoma and Wilms’ tumor) through various upstream mechanisms. Laboratory evidence and clinical trials of targeted therapies specific to exploiting p53 upstream regulators are discussed.SummaryDespite the low rate of inherentTP53mutations, p53 pathway inactivation is a common denominator in childhood blastomas. Exploiting p53 and its regulators is likely to translate into more effective targeted therapies with minimal late effects for children. (see Video Abstract, Supplemental Digital Content 1, http://links.lww.com/COON/A23).
Prevalence of Pigment Dispersion Syndrome in Patients Seeking Refractive Surgery
Authors: Doane John F. , Rickstrew Jace J. , Tuckfield James Q. , Cauble Jae E. 
Published: January 2019

Purpose:
To determine the prevalence of pigment dispersion syndrome (PDS) in patients presenting for vision correcting refractive surgery.

Setting:
Discover Vision Centers, Kansas City, MO.

Design:
This is a prospective case series.

Materials and Methods:
A total of 637 eyes of 319 serial patients who presented seeking refractive surgery were included in this prospective, observational study. Patients underwent routine ophthalmologic examination before refractive surgery. PDS was diagnosed by the presence of a deep anterior chamber, posterior bowing of the irides, Krukenberg spindles, and/or presence of mid-peripheral iris transillumination defects by the same experienced ophthalmologist. The prevalence of PDS and its associated ophthalmic and demographic characteristics were evaluated in those diagnosed.

Results:
Of the 637 eyes, 165 (25.9%) eyes were diagnosed with PDS. Krukenberg spindles were present in 53 (8.3%) of the total eyes and in 47 (28.5%) eyes that were diagnosed with PDS. Transillumination defects were present in 153 (95%) eyes diagnosed with PDS and 161 (25.2%) total eyes. There was equal distribution between sex in those diagnosed with PDS (male vs. female: 26 vs. 25.8%; P=0.942). Blue colored eyes were most likely to have PDS (35.8% of patients).

Conclusions:
The prevalence of PDS within the population of patients seeking refractive surgery is likely greater than the general population as a whole. This is most likely the result of self-selection and high association between myopia and PDS. Given that not infrequent sequela can occur from untreated PDS, it is prudent that refractive surgeons be aware of this increased prevalence and perform thorough examinations to properly identify the condition.
Neoadjuvant chemotherapy reduces the expression rates of ER, PR, HER2, Ki67, and P53 of invasive ductal carcinoma
Authors: Peng Jian-Heng , Zhang Xiang , Song Jun-Long , Ran Liang , Luo Rong , Li Hong-Yuan , Wang Yong-Hong 
Published: January 2019

Abstract
To analyze whether neoadjuvant chemotherapy (NAC) changes the expression rates of invasive ductal carcinoma (IDC) markers: estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), Ki67, and P53.
This was a retrospective study of 112 IDC patients who underwent NAC (docetaxel+epirubicin/pirarubicin+cyclophosphamide) but without pathological complete response (pCR) in 2012 to 2013 at the First Affiliated Hospital of Chongqing Medical University. The IDC subtypes and tumor protein markers were analyzed by immunohistochemistry (IHC). Specific changes in tumor protein markers before/after NAC were compared.
The decrease in the positive rate of Ki-67 was the most significant, from 75.9% before NAC to 41.1% after NAC (P < .001). The positive rate of HER2 decreased from 42.0% before NAC to 32.1% after NAC (P = .04). The positive rate of ER decreased from 66.1% before NAC to 56.2% after NAC (P = .04). Increased number of metastatic lymph nodes (P = .006) and body mass index (BMI) (P = .028) seemed to be related to conversion of PR (positive to negative). There was statistical association between the Ki-67 (positive to negative) with the age greater or equal to 50 (P = .015). The BMI greater or equal to 24 (P = .021), age greater or equal to 50 (P = .047), and blood type A (P = .038) were independently associated with conversion of P53 (positive to negative). The BMI greater or equal to 24 (P = .004), number of metastatic lymph nodes greater or equal to 1 (P = .029) and TNM stages I–II (P = .008) were statistically associated with change of HER2 (positive to negative).
In patients without pCR, NAC leads to changes in Ki-67, HER2, and hormone receptor (HR) expression. Age, BMI, number of metastatic lymph nodes, and TNM stage are associated with some changes of markers.