bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of self-reported weight in the Women’s Health Initiative
Authors: Luo Juhua , Thomson Cynthia A , Hendryx Michael , Tinker Lesley F , Manson JoAnn E , Li Yueyao , Nelson Dorothy A , Vitolins Mara Z , Seguin Rebecca A , Eaton Charles B , Wactawski-Wende Jean , Margolis Karen L 
Published: November 2018

AbstractObjectiveTo assess the extent of error present in self-reported weight data in the Women’s Health Initiative, variables that may be associated with error, and to develop methods to reduce any identified error.DesignProspective cohort study.SettingForty clinical centres in the USA.ParticipantsWomen (n 75 336) participating in the Women’s Health Initiative Observational Study (WHI-OS) and women (n 6236) participating in the WHI Long Life Study (LLS) with self-reported and measured weight collected about 20 years later (2013–2014).ResultsThe correlation between self-reported and measured weights was 0·97. On average, women under-reported their weight by about 2 lb (0·91 kg). The discrepancies varied by age, race/ethnicity, education and BMI. Compared with normal-weight women, underweight women over-reported their weight by 3·86 lb (1·75 kg) and obese women under-reported their weight by 4·18 lb (1·90 kg) on average. The higher the degree of excess weight, the greater the under-reporting of weight. Adjusting self-reported weight for an individual’s age, race/ethnicity and education yielded an identical average weight to that measured.ConclusionsCorrelations between self-reported and measured weights in the WHI are high. Discrepancies varied by different sociodemographic characteristics, especially an individual’s BMI. Correction of self-reported weight for individual characteristics could improve the accuracy of assessment of obesity status in postmenopausal women.
Management of the dead from the Islamic law and international humanitarian law perspectives: Considerations for humanitarian forensics
Authors: Al-Dawoody Ahmed 
Published: November 2018

AbstractThis article discusses a number of contemporary issues and challenges pertinent to the management of the dead in contemporary armed conflicts and other situations of violence and natural disasters under Islamic law and international humanitarian law. Among the issues and challenges faced by forensic specialists in Muslim contexts at present are collective burial, quick burial of dead bodies, exhumation of human remains, autopsy, burial at sea, and handling of the bodies by the opposite sex. The article concludes that both legal systems have developed rules which aim at the protection of the dignity and respect of dead bodies, and that they complement each other to achieve this protection in specific Muslim contexts. The main objectives of this article are twofold: firstly, to give an overview of the Islamic law position on these specific questions and challenges, in order to, secondly, provide some advice or insight into how forensic specialists can deal with them.
The Sri Lankan Office on Missing Persons: Truth and justice in tandem?
Authors: Lassée Isabelle 
Published: November 2018

AbstractIn October 2015, by co-sponsoring United Nations Human Rights Council Resolution 30/1 entitled “Promoting Reconciliation, Accountability and Human Rights in Sri Lanka”, the Sri Lankan government formally committed to embarking on a transitional justice process following three decades of armed conflict. Several thousand people allegedly disappeared during this period, often in connection with the armed conflict or as a result of internal disturbances. It is in this context that the Office on Missing Persons (OMP) was operationalized in 2018. This article discusses the nature of tracing investigations into the fate and whereabouts of missing persons of the type to be carried out by the OMP. It argues that these investigations, while ostensibly pursuing a humanitarian approach, cannot be artificially and hermetically separated from criminal justice processes. Further, it seeks to demonstrate that an integrated approach whereby strong linkages with criminal processes are provided for and encouraged best serves the interests of truth and justice.
Validation of a Short Form of Job Crafting Scale in a Spanish Sample
Authors: Sora Beatriz , Caballer Amparo , García-Buades Esther 
Published: November 2018

AbstractApplications of job crafting are widespread in the professional practice. In an attempt to measure this phenomenon, Tims, Bakker and Derks (2012) developed a Job Crafting Scale based on the Job Demand-Resources model (JD-R) and validated it in a Dutch sample. However, its application to other cultural contexts presented some difficulties. The present work aimed to validate a shorter version of scale by Tims et al. (2012) in a Spanish sample (n = 1,647). The data were randomly split in two independent subsamples (Sample 1: Explorative; Sample 2: Confirmative). The exploratory factor analysis showed a three-factor structure. Through a confirmatory factor analysis, the four-dimensionality structure of the original scale was replicated. In fact, the four-factor solution presented better goodness of fit indices than the alternative one-factor model, χ2(48) = 192.70, p < .01; AGFI = .94; NNFI = .93; RMR = .05; RMSEA = .06. Alpha reliabilities were acceptable for increasing structural job resources (α = .75), decreasing hindering job demands (α = .64), increasing social job resources (α = .78) and increasing challenging job demands (α = .77). Convergent validity was appropriate for three of the four dimensions, because each construct’s AVE were around .50 and each construct’s Composite Reliability were around .70. Decreasing hindering job demands presented more limited values (CR = .65; AVE = .40). In addition, the four job crafting dimensions presented significant correlations with job performance (range –.09 to .42) and personal growth (ranging from –.09 to .45). Finally, the squared correlations between factors were lower than the square root of AVE, which confirmed discriminant validity.
Time‐Dependent Pore Filling
Authors: Sun Zhonghao , Jang Junbong , Santamarina J. Carlos 
Published: November 2018

AbstractCapillarity traps fluids in porous media during immiscible fluid displacement. Most field situations involve relatively long time scales, such as hydrocarbon migration into reservoirs, resource recovery, nonaqueous phase liquid remediation, geological CO2 storage, and sediment‐atmosphere interactions. Yet laboratory studies and numerical simulations of capillary phenomena rarely consider the impact of time on these processes. We use time‐lapse microphotography to record the evolution of saturation in air‐ or hydrocarbon‐filled capillary tubes submerged in water to investigate long‐term pore filling phenomena beyond imbibition. Microphotographic sequences capture a lively pore filling history where various concurrent physical phenomena coexist. Dissolution and diffusion play a central role. Observations indicate preferential transport of the wetting liquid along corners, vapor condensation, capillary flow induced by asymmetrical interfaces, and interface pinning that defines the diffusion length. Other processes include internal snap‐offs, fluid redistribution, and changes in wettability as fluids dissolve into each other. Overall, the rate of pore filling is diffusion‐controlled for a given interfacial configuration; diffusive transport takes place at a constant rate for pinned interfaces and is proportional to the square root of time for free interfaces where the diffusion length increases with time.
GeoFlood: Large‐Scale Flood Inundation Mapping Based on High‐Resolution Terrain Analysis
Authors: Zheng Xing , Maidment David R. , Tarboton David G. , Liu Yan Y. , Passalacqua Paola 
Published: November 2018

AbstractRecent floods from intense storms in the southern United States and the unusually active 2017 Atlantic hurricane season have highlighted the need for real‐time flood inundation mapping using high‐resolution topography. High‐resolution topographic data derived from lidar technology reveal unprecedented topographic details and are increasingly available, providing extremely valuable information for improving inundation mapping accuracy. The enrichment of terrain details from these data sets, however, also brings challenges to the application of many classic approaches designed for lower‐resolution data. Advanced methods need to be developed to better use lidar‐derived terrain data for inundation mapping. We present a new workflow, GeoFlood, for flood inundation mapping using high‐resolution terrain inputs that is simple and computationally efficient, thus serving the needs of emergency responders to rapidly identify possibly flooded locations. First, GeoNet, a method for automatic channel network extraction from high‐resolution topographic data, is modified to produce a low‐density, high‐fidelity river network. Then, a Height Above Nearest Drainage (HAND) raster is computed to quantify the elevation difference between each land surface cell and the stream bed cell to which it drains, using the network extracted from high‐resolution terrain data. This HAND raster is then used to compute reach‐average channel hydraulic parameters and synthetic stage‐discharge rating curves. Inundation maps are generated from the HAND raster by obtaining a water depth for a given flood discharge from the synthetic rating curve. We evaluate our approach by applying it in the Onion Creek Watershed in Central Texas, comparing the inundation extent results to Federal Emergency Management Agency 100‐yr floodplains obtained with detailed local hydraulic studies. We show that the inundation extent produced by GeoFlood overlaps with 60%~90% of the Federal Emergency Management Agency floodplain coverage demonstrating that it is able to capture the general inundation patterns and shows significant potential for informing real‐time flood disaster preparedness and response.
Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy
Authors: Wang Meng , Han Dong , Yuan Ziming , Hu Hanqing , Zhao Zhixun , Yang Runkun , Jin Yinghu , Zou Chaoxia , Chen Yinggang , Wang Guiyu , Gao Xu , Wang Xishan 
Published: November 2018

AbstractChemotherapy failure is the major cause of recurrence and poor prognosis in colorectal cancer (CRC) patients. The role of the differentially expressed lncRNAs in 5-Fluorouracil chemoresistance has not fully explained. Here, we observed lncRNA H19 was associated with the 5-Fu resistance in CRC. Quantitative analysis indicated that H19 was significantly increased in recurrent CRC patient samples. Kaplan–Meier survival analysis indicated that high H19 expression in CRC tissues was significantly associated with poor recurrent free survival. Our functional studies demonstrated that H19 promoted colorectal cells 5-Fu resistance. Mechanistically, H19 triggered autophagy via SIRT1 to induce cancer chemoresistance. Furthermore, bioinformatics analysis showed that miR-194–5p could directly bind to H19, suggesting H19 might work as a ceRNA to sponge miR-194–5p, which was confirmed by Dual-luciferase reporter assay and Immunoprecipitation assay. Extensively, our study also showed that SIRT1 is the novel direct target of miR-194–5p in CRC cells. Taken together, our study suggests that H19 mediates 5-Fu resistance in CRC via SIRT1 mediated autophagy. Our finding provides a novel mechanistic role of H19 in CRC chemoresistance, suggesting that H19 may function as a marker for prediction of chemotherapeutic response to 5-Fu.
Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery
Authors: Holland Olivia J. , Cuffe James S. M. , Dekker Nitert Marloes , Callaway Leonie , Kwan Cheung Keith A. , Radenkovic Filip , Perkins Anthony V. 
Published: November 2018

AbstractPreeclampsia is a devastating pregnancy disorder. Severity varies widely, and while severe preeclampsia often requires pre-term delivery, women with mild preeclampsia may reach term with minor interventions. The mechanisms that mediate disease severity are poorly understood, but may include adaptive processes by the placenta. We aimed to establish whether in pregnancies that reached term and those that delivered pre-term, the placental response to preeclampsia was intrinsically different, and explore potential adaptive mechanisms. Hydrogen peroxide production and antioxidant activity were increased in term preeclamptic placentae, whereas pre-term preeclamptic placentae had reduced hydrogen peroxide production and reduced function of the antioxidant system superoxide dismutase compared to control placentae. Markers of mitochondrial fission/fusion, apoptosis and the expression level of mitochondrial complexes were differentially disrupted in term compared to pre-term preeclamptic placentae. Mitochondrial respiration and content were increased in term preeclamptic placentae, but mitochondria had a lower respiratory reserve capacity. Mitochondrial respiration and hydrogen peroxide production were increased in healthy term placentae after in vitro hypoxia/reoxygenation. Placentae from preeclamptic pregnancies that reached term showed multiple adaptions that were not present in pre-term preeclamptic placentae. Increased antioxidant activity, and expression of markers of mitochondrial fusion and apoptotic suppression, may relate to salvaging damaged mitochondria. Increased mitochondrial respiration may allow ongoing tissue function even with reduced respiratory efficiency in term preeclamptic pregnancies. Response after in vitro hypoxia/reoxygenation suggests that disruption of oxygen supply is key to placental mitochondrial adaptations. Reactive oxygen species signalling in term preeclamptic placentae may be at a level to trigger compensatory antioxidant and mitochondrial responses, allowing tissue level maintenance of function when there is organelle level dysfunction.
Orchestration of protein acetylation as a toggle for cellular defense and virus replication
Authors: Murray L. A. , Sheng X. , Cristea I. M. 
Published: November 2018

AbstractEmerging evidence highlights protein acetylation, a prevalent lysine posttranslational modification, as a regulatory mechanism and promising therapeutic target in human viral infections. However, how infections dynamically alter global cellular acetylation or whether viral proteins are acetylated remains virtually unexplored. Here, we establish acetylation as a highly-regulated molecular toggle of protein function integral to the herpesvirus human cytomegalovirus (HCMV) replication. We offer temporal resolution of cellular and viral acetylations. By interrogating dynamic protein acetylation with both protein abundance and subcellular localization, we discover finely tuned spatial acetylations across infection time. We determine that lamin acetylation at the nuclear periphery protects against virus production by inhibiting capsid nuclear egress. Further studies within infectious viral particles identify numerous acetylations, including on the viral transcriptional activator pUL26, which we show represses virus production. Altogether, this study provides specific insights into functions of cellular and viral protein acetylations and a valuable resource of dynamic acetylation events.
Mediated nuclear import and export of TAZ and the underlying molecular requirements
Authors: Kofler Michael , Speight Pam , Little Darby , Di Ciano-Oliveira Caterina , Szászi Katalin , Kapus András 
Published: November 2018

AbstractNucleocytoplasmic distribution of Yap/TAZ is regulated by the Hippo pathway and the cytoskeleton. While interactions with cytosolic and nuclear “retention factors” (14–3–3 and TEAD) are known to control their localization, fundamental aspects of Yap/TAZ shuttling remain undefined. It is unclear if translocation occurs only by passive diffusion or via mediated transport, and neither the potential nuclear localization and efflux signals (NLS, NES) nor their putative regulation have been identified. Here we show that TAZ cycling is a mediated process and identify the underlying NLS and NES. The C-terminal NLS, representing a new class of import motifs, is necessary and sufficient for efficient nuclear uptake via a RAN-independent mechanism. RhoA activity directly stimulates this import. The NES lies within the TEAD-binding domain and can be masked by TEAD, thereby preventing efflux. Thus, we describe a RhoA-regulated NLS, a TEAD-regulated NES and propose an improved model of nucleocytoplasmic TAZ shuttling beyond "retention".
A machine learning approach to model solute grain boundary segregation
Authors: Huber Liam , Hadian Raheleh , Grabowski Blazej , Neugebauer Jörg 
Published: November 2018

AbstractEven minute amounts of one solute atom per one million bulk atoms may give rise to qualitative changes in the mechanical response and fracture resistance of modern structural materials. These changes are commonly related to enrichment by several orders of magnitude of the solutes at structural defects in the host lattice. The underlying concept—segregation—is thus fundamental in materials science. To include it in modern strategies of materials design, accurate and realistic computational modelling tools are necessary. However, the enormous number of defect configurations as well as sites solutes can occupy requires models which rely on severe approximations. In the present study we combine a high-throughput study containing more than 1 million data points with machine learning to derive a computationally highly efficient framework which opens the opportunity to model this important mechanism on a routine basis.
New insights into structural features and optimal detection of circulating tumor DNA determined by single-strand DNA analysis
Authors: Sanchez Cynthia , Snyder Matthew W. , Tanos Rita , Shendure Jay , Thierry Alain R. 
Published: November 2018

AbstractCirculating cell-free DNA (cfDNA) has received increasing interest as an apparent breakthrough approach in diagnostics, personalized medicine, and tumor biology. However, the structural features of cfDNA are poorly characterized. Specifically, the literature has discrepancies with regards to cfDNA size profile. We performed a blinded study of the distribution of cfDNA fragment sizes in cancer patient plasma (n = 11), by various ultra-deep-sequencing approaches and quantitative PCR (Q-PCR). Whole-genome sequencing of single-stranded DNA library preparation (SSP-S) revealed that nearly half of the total cfDNA fragment number are below 120 nucleotides, which are not readily detectable by standard double-stranded DNA library preparation (DSP) protocols. Fractional size distribution of cancer patient circulating DNA was very similar using both SSP-S-based or Q-PCR-based methods also revealing that high molecular weight (over 350 bp) cfDNA is a minor component (~2%). These extra small detected cfDNA fragments may mostly result from nicks occurring in blood circulation in one or both DNA strands, which are subsequently revealed through the denaturation step of the SSP and Q-PCR procedures. Detailed analysis of the data suggested that most of the detectable cfDNA in blood has a nucleosome footprint (∼10-bp periodicity repeats). The nucleosome is thus the most stabilizing structure of DNA in the circulation. cfDNA molecules, which are initially packed in chromatin, are released from cells and are then dynamically degraded in blood both within and between nucleosomes or transcription factor-associated subcomplexes. While this study provides new insights into cfDNA size profiles harmonizing sequencing and Q-PCR findings, our data validate the use of a specific Q-PCR method and SSP-S for obtaining an optimal qualitative and quantitative analytical signal.
Transcriptional profiling of the mutualistic bacterium Vibrio fischeri and an hfq mutant under modeled microgravity
Authors: Duscher Alexandrea A. , Conesa Ana , Bishop Mary , Vroom Madeline M. , Zubizarreta Sergio D. , Foster Jamie S. 
Published: November 2018

AbstractFor long-duration space missions, it is critical to maintain health-associated homeostasis between astronauts and their microbiome. To achieve this goal it is important to more fully understand the host–symbiont relationship under the physiological stress conditions of spaceflight. To address this issue we examined the impact of a spaceflight analog, low-shear-modeled microgravity (LSMMG), on the transcriptome of the mutualistic bacteriumVibrio fischeri. Cultures ofV. fischeriand a mutant defective in the global regulator Hfq (∆hfq) were exposed to either LSMMG or gravity conditions for 12 h (exponential growth) and 24 h (stationary phase growth). Comparative transcriptomic analysis revealed few to no significant differentially expressed genes between gravity and the LSMMG conditions in the wild type or mutantV. fischeriat exponential or stationary phase. There was, however, a pronounced change in transcriptomic profiles during the transition between exponential and stationary phase growth in bothV. fischericultures including an overall decrease in gene expression associated with translational activity and an increase in stress response. There were also several upregulated stress genes specific to the LSMMG condition during the transition to stationary phase growth. The ∆hfqmutants exhibited a distinctive transcriptome profile with a significant increase in transcripts associated with flagellar synthesis and transcriptional regulators under LSMMG conditions compared to gravity controls. These results indicate the loss of Hfq significantly influences gene expression under LSMMG conditions in a bacterial symbiont. Together, these results improve our understanding of the mechanisms by which microgravity alters the physiology of beneficial host-associated microbes.
Dorsal-zone-specific reduction of sensory neuron density in the olfactory epithelium following long-term exercise or caloric restriction
Authors: Tuerdi Ayinuer , Kikuta Shu , Kinoshita Makoto , Kamogashira Teru , Kondo Kenji , Iwasaki Shinichi , Yamasoba Tatsuya 
Published: November 2018

AbstractExercise (Ex) and caloric restriction (CR) reduce oxidative stress and improve organ function. For instance, voluntary Ex or CR is known to reduce age-related cochlear damage in male C57BL/6J mice. However, the effect of Ex and CR on the olfactory system is unknown. In this study, we confirmed the positive effect of Ex and CR on age-related cochlear damage, but found that Ex and CR affected negatively cell dynamics in the olfactory epithelium (OE) by reducing the number of mature olfactory sensory neurons (OSNs) and increasing the number of proliferative basal cells and apoptotic OSNs in the dorsal zone of the olfactory epithelium (OE), which contains neurons expressing NADPH quinone oxido-reductase 1 (NQO1). In addition, these interventions resulted in lower odor-induced c-fos expression in areas of the olfactory bulb receiving projections from dorsal-zone OSNs than in areas receiving ventral-zone projections. Further, we observed substantial oxidative stress in NQO1-positive cells and apoptotic OSNs in the dorsal zone in Ex and CR animals. These results suggest that, in contrast to their positive effects in other organs, Ex and CR facilitate oxidative stress and negatively impact structure and function in dorsal-zone OSNs, probably in association with NQO1 bioactivation.