bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing Lithium‐Diffusion Barrier on the Wadsley–Roth Crystallographic Shear Plane via Low‐Valent Cation Doping for Ultrahigh Power Lithium‐Ion Batteries
Authors: Ma Jun , Xiang Yu , Xu Jingyue , Zhang Wenfeng , Zhang Huimin , Qiu Jingyi , Zhu Xiayu , Zhang Hao , Lin Haiping , Cao Gaoping 
Published: December 2024

AbstractRapid‐charging niobium–tungsten oxide Nb14W3O44 (NbWO) anodes with a Wadsley–Roth crystallographic shear (WRCS) structure possess 3D interconnected open tunnels. However, the anisotropic Li+ diffusion paths lead to a high lithium‐diffusion barrier of hooping between window sites across edge‐shared octahedrons, as the rate‐limiting step of hooping. To improve the rate capability of NbWO, doping it with low‐valent cations (with valences lower than W6+) to reduce the high lithium‐diffusion barrier is proposed. Electron energy loss spectroscopy reveals that low‐valent V5+, V4+, Tb4+, and Ce4+ tend to distribute on the crystallographic shear plane under electrostatic repulsion forces. The reduction in steric hindrance resulting from the increased long bond length ratio of doped edge‐shared octahedrons, coupled with coordination environment modification of [LiO5] on the crystallographic shear plane due to the low energy level of V5+, enhances Li+ diffusion kinetics and cyclic stability. V5+‐ and Tb4+‐doped NbWOs achieve rate capacities of 83 and 63 mAh g−1, at 200 C (1C = 0.178 Ag−1) and retain 75.42% and 86.79% of their capacities, respectively, after 3700 cycles at 20 C. Thus, the proposed doping strategy is promising for preparing WRCS‐type niobium‐based oxides for ultrafast lithium storage.
Synthesis and Characterization of Novel Mesomorphic Chromenonapthophenathridines
Authors: Vadivel Marichandran , K Swamynathan , Raghunathan V. A. , Kumar Sandeep 
Published: December 2024

AbstractHeterocyclic discotic liquid crystals containing heteroatoms such as O, N, S, Se, P as part of π‐conjugated framework has revolutionized organic semiconductors research. The presence of heteroatom in π‐conjugated core has been reported to strikingly influence the self‐assembling properties. In this work we have synthesized novel chromenophenanthridines where the incorporation of oxygen facilitates the in plane ordering of central core and improves liquid crystalline character in these molecules. This paper elucidates the mesomorphic behavior of chromenonapthophenanthridines prepared via tandem Pictet Spengler cyclisation and ipso‐aromatic substitution in one pot. The synthesized compounds exhibited wide range enantiotropic columnar hexagonal phase. The mesomorphic behavior was suggested as a function of peripheral alkyl chains. The shorter homologue was found to exhibit hexagonal columnar plastic phase whereas higher ones exhibit hexagonal columnar phase.
Association between dietary inflammatory index score and incident dementia
Authors: van Lent Debora Melo , Mesa Hannah Gokingco , Short Meghan I. , Gonzales Mitzi M. , Aparicio Hugo J. , Salinas Joel , Yuan Changzheng , Jacques Paul F. , Beiser Alexa , Seshadri Sudha , Jacob Mini E. , Himali Jayandra J. 
Published: December 2024

AbstractINTRODUCTIONWe evaluated whether higher Dietary Inflammatory Index (DII) scores were associated with increased incidence of all‐cause dementia and Alzheimer's disease (AD) dementia over 22.3 years of follow‐up in the community‐based Framingham Heart Study Offspring cohort.METHODSOne thousand four hundred eighty‐seven participants (mean ± standard deviation, age in years 69 ± 6) completed food frequency questionnaires (FFQs) and had incident all‐cause dementia and AD surveillance data available.RESULTSTwo hundred forty‐six participants developed all‐cause dementia (including AD, n = 187) over a median follow‐up time of 13.1 years. Higher DII scores, averaged across a maximum of three timepoints, were associated with an increased incidence of all‐cause dementia and AD after adjustment for demographic, lifestyle, and clinical covariates (hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.10–1.33, P < 0.001; HR 1.20, 95% CI: 1.07–1.34d, P = 0.001, respectively).DISCUSSIONHigher DII scores were associated with a higher risk of incident all‐cause dementia and AD. Although these promising findings need to be replicated and further validated, our results suggest that diets that correlate with low DII scores may prevent late‐life dementia.Highlights
Higher Dietary Inflammatory Index (DII) scores were associated with an increased incidence of all‐cause dementia.
Higher DII scores were associated with an increased incidence of Alzheimer's disease dementia.
Diets that correlate with low DII scores may prevent late‐life dementia.
Locus coeruleus tau is linked to successive cortical tau accumulation
Authors: Yi Dahyun , Byun Min Soo , Jung Joon Hyung , Jung Gijung , Ahn Hyejin , Chang Yoon Young , Keum Musung , Lee Jun‐Young , Lee Yun‐Sang , Kim Yu Kyeong , Kang Koung Mi , Sohn Chul‐Ho , Risacher Shannon L. , Saykin Andrew J. , Lee Dong Young ,   the KBASE Research Group
Published: December 2024

AbstractINTRODUCTIONWe investigated the hypothesis that tau burden in the locus coeruleus (LC) correlates with tau accumulation in cortical regions according to the Braak stages and examined whether the relationships differed according to cortical amyloid beta (Aβ) deposition.METHODSOne hundred and seventy well‐characterized participants from an ongoing cohort were included. High‐resolution T1, tau positron emission tomography (PET), and amyloid PET were obtained.RESULTSLC tau burden was significantly linked to global tau in neocortical regions, as was tau in both early Braak stage (stage I/II) and later Braak stage areas. This relationship was significant only in Aβ‐positive individuals. While LC tau did not directly impact memory, it was indirectly associated with delayed memory through mediation or moderation pathways.DISCUSSIONThe findings from living human brains support the idea that LC tau closely relates to subsequent cortical tau accumulation, particularly among individuals with pathological Aβ accumulation, and identify LC tau burden as a promising indicator of cognitive trajectories of AD.Highlights
Tau burden in the LC was significantly associated with cortical tau accumulation.
Tau burden in SN or PPN showed no association with cortical tau accumulation.
LC tau burden was serially associated with Braak stages.
The tau‐LC and cortical tau relationship was significant only in the Aβ‐positive group.
Cortical amyloid's impact on memory worsens with higher tau accumulation in the LC.
Exerkines mitigating Alzheimer's disease progression by regulating inflammation: Focusing on macrophage/microglial NLRP3 inflammasome pathway
Authors: Cheon Jaehwan , Kwon Soonyong , Kim Mikyung 
Published: December 2024

AbstractRecent research highlights the critical role of inflammation in accelerating amyloid beta and phosphorylated tubulin‐associated protein tau cascade and Alzheimer's disease (AD) progression. Emerging evidence suggests that exercise influences AD by modulating inflammatory responses. We conducted a comprehensive search across multiple online databases. Our approach focused on previous and recent studies exploring the links among inflammation, AD, and the effects of exercise, specifically targeting research articles and books published in English. We pointed out that inflammation extends from the periphery to the central nervous system, facilitated by macrophage/microglial NLRP3 (nucleotide‐binding domain, leucine rich–containing family, pyrin domain–containing protein 3) inflammasome signaling, which exacerbates classical AD mechanisms. Moreover, we provided further insights into the modulation of inflammasome signaling through exercise and exerkines, which may contribute to mitigating AD development. These insights deepen our understanding of AD mechanisms and offer the potential for identifying key therapeutic targets and biomarkers crucial for effective disease management and treatment.Highlights
Inflammation is potentially linked to the acceleration of classical Alzheimer's disease (AD) pathogenesis, including the pathways involving amyloid beta and phosphorylated tau, mediated by pro‐inflammatory cytokines.
Inflammation, initiated by the nucleotide‐binding domain, leucine rich–containing family, pyrin domain–containing protein 3 (NLRP3) inflammasome signaling pathway within M1‐type macrophages/microglia, may contribute to neuroinflammation and AD progression.
Exercise has the potential to reduce inflammation and the development of AD by influencing NLRP3 inflammasome signaling via exerkines.
Developing and applying potentially scalable recruitment strategies to accelerate ADRD research participation of Black adults
Authors: Richards Ralph , Richards Mollie , Musema Jane , Tackett Andrew , Van Heiden Sarah , Polsinelli Angelina , Gao Sujuan , Brown Steven A. , Unverzagt Frederick W. , Risacher Shannon , Adeoye‐Olatunde Omolola , Campbell Christopher , Shaw Pamella , Saykin Andrew , Wang Sophia 
Published: December 2024

AbstractMore than 2 million older Americans from underrepresented racial and ethnic minority groups (URGs) have early‐stage Alzheimer's disease and related dementias (ADRD). There are very few scalable recruitment strategies, particularly for Black older adults, to accelerate participation in ADRD research. The Indiana Alzheimer's Disease Research Center (IADRC) and its Community Advisory Board developed and implemented the innovative RAAISE‐D Framework. This Framework informed the creation of community‐first recruitment strategies designed to accelerate participation of Black older adults in ADRD research. Preliminary outcomes from its implementation included the doubling of Black adult enrollment (46, 13.4% to 101, 26.9%) from April 2020 to April 2024. Black adults were more likely to have normal cognition, be female, and ≤ 12 years of education than non‐Hispanic White adults. The RAAISE‐D Framework identified key concepts for URG focused recruitment strategies which successfully accelerated enrollment of Black adults in ADRD research and could be generalized to other URGs.Highlights
RAAISE‐D Framework provides adaptable URG recruitment strategies.
IADRC CAB‐researcher partnership was the foundation of community‐first methodology.
RAAISE‐D Framework doubled the Black enrollment in the IADRC in 4 years.
Unexpected Magnetic Moments in Manganese‐Doped (CdSe)13 Nanoclusters: Role of Ligands
Authors: Huang Guo‐Lun , Ting Ko.‐Yu , Narayanam Nagaraju , Wu Dong‐Rong , Hsieh Tzung‐En , Tsai Kai‐Chih , Yang Da‐Wei , Tang Qi‐Xun , Su Bo‐Kai , Kang Yu‐Ting , Huang Shing‐Jong , Chen Ching‐Hsiang , Chang Yuan‐Pin , Yang Lan‐Sheng , Chao Yu‐Chiang , Li Elise Yu‐Tzu , Liu Yi‐Hsin 
Published: December 2024

AbstractThis study explores the enhancement in magnetic and photoluminescence properties of Mn2+‐doped (CdSe)13 nanoclusters, significantly influenced by the introduction of paramagnetic centers through doping, facilitated by optimized precursor chemistry and precisely controlled surface ligand interactions. Using a cost‐effective and scalable synthesis approach with elemental Se and NaBH4 (Se‐NaBH4) in n‐octylamine, we tailored bonding configurations (Cd−O, Cd−N, and Cd−Se) on the surface of nanoclusters, as confirmed by EXAFS analysis. These bonding configurations allowed for tunable Mn2+‐doping with tetrahedral coordination, further stabilized by hydrogen‐bonded acetate ligands, as evidenced by 13C NMR and IR spectroscopy. Mulliken charge analysis indicates that the charge redistribution on Se2− suggests electron transfer between surface ligands and the nanocluster, contributing to spin fluctuations. These tailored configurations markedly increased the nanoclusters′ magnetic susceptibility and photoluminescence efficiency. The resulting nanoclusters demonstrated a clear concentration‐dependent response in emission lifetimes and intensities upon exposure to magnetic field effects (MFE) and spin‐spin coupling, alongside a large magnetic moment exceeding 40 μB at 180 K. These findings highlight the potential of these nanoclusters for magneto‐optical devices and spintronic applications, showcasing their tunable magnetic properties and exciton dynamics.
3D‐Printable Polymer Filters for the Selective Complexation of Silver Ions
Authors: Koswig Timo , Meurer Josefine , Bätz Thomas , Müschke Oswald , Zechel Stefan , Hager Martin D. , Schubert Ulrich S. 
Published: December 2024

ABSTRACTThis study presents the fabrication of polymeric filters, which are able to selectively bind silver ions from aqueous solution. Those filters are fabricated within an easy approach via 3D‐digital light processing (DLP)‐printing enabling a tailor‐made design. In first order, an acrylamide containing a benzo‐trithiacrown‐ether (BTCE) functionality is synthesized. This monomer is further 3D‐printed via layer by layer photo‐polymerization together with commercially available comonomers, resulting in polymer networks containing the BTCE‐groups in their side chains as selective binding moiety for silver ions. Within isothermal‐titration calorimetry (ITC) measurements, the complexation abilities of the BTCE to bind the Ag+ ions are determined. Furthermore, the resulting 3D‐printed filters are investigated regarding their complexation behavior, in a detailed fashion applying inductively coupled plasma optical emission spectroscopy (ICP‐OES).
Upcycling of Postconsumer PET Using Serinol: Green Preparation of a New Multifunctional Initiator for PLA
Authors: Truscello Ada , Sartiano Chiara , Galimberti Maurizio Stefano , Gambarotti Cristian , Gazzotti Stefano , Ortenzi Marco Aldo 
Published: December 2024

ABSTRACTChemical recycling is attracting more and more interest as it can transform a plastic scrap into a high‐value material. This work shows that the aminolysis of postconsumer poly(ethyleneterephthalate) (PET) with serinol, a nontoxic and biosourced hydroxyamine, leads to a novel multifunctional initiator for poly(lactic acid) (PLA). The reaction was performed at 180°C, without the need of catalysts, and resulted in a substantially complete aminolysis of PET, selectively yielding the corresponding diamide of terephthalic acid (terephthalic acid serinol bis‐amide, TASBA), together with ethylene glycol as the co‐product. TASBA holds four hydroxy groups and was used as multifunctional initiator in the polymerization of lactide to PLA, with 0.1%, 0.5%, and 1% w/w of TASBA with respect to L‐lactide. TASBA led to a multiarm PLA, whose molecular weight and thermal and rheological properties could be tuned with the amount of initiator. The lowest amount of initiator left substantially unaffected the molecular weight and led to higher melt viscosity and to lower crystallinity. Lower molecular weight and melt viscosity were obtained by increasing the amount of TASBA. This work therefore proposes a synergy between the most important polyesters, the most diffused PET and the compostable PLA.
A comprehensive review of the application of cold plasma technology in lignocellulosic biomass pretreatment
Authors: Abolore Rasaq S. , Jaiswal Swarna , Jaiswal Amit K. 
Published: December 2024

AbstractLignocellulosic biomass (LCB) is a promising feedstock for the sustainable production of biofuels and other biobased products, owing to its abundance, low cost, and minimal competition with food crops for resources. It is mainly composed of cellulose, hemicellulose, and lignin, forming a complex biomass matrix. Its utilization is hindered by its complex structure and pretreatment is required to break down the chemical resistance caused by the strong association between the cellulose, hemicellulose, and lignin structures. Conventional methods such as acid and alkali pretreatment are used frequently but they require the use of high temperatures, high pressure, and corrosive chemicals. This has encouraged research into environmentally friendly pretreatments to overcome these challenges. Recently, cold plasma (CP) technology has emerged as a promising alternative to the aggressive conventional methods for producing value‐added products, such as biofuels, and renewable chemicals from lignocellulosic biomass. Cold plasma technology uses electricity to generate a highly reactive, ionized gas in a variety of applications without producing any dangerous or polluting compounds. This review discusses the application of cold atmospheric pressure plasma in the biochemical conversion of biomass, with a focus on delignification, detoxification of biomass hydrolysate, surface modifications, and process intensification of cellulosic ethanol production.
A Comprehensive Review of Lavandula stoechas L. (Ustukhuddus) Plant: Phytochemistry, Pharmacology, and In Silico Studies
Authors: Ahamad Rizwan , Kumar Satendra , Akhtar Mohd. , Aqil Mohd. , Yar Mohammad Shahar , Akram Mohd. , Ismail Mohd. Vaseem , Mujeeb Mohd. 
Published: December 2024

ABSTRACTLavandula stoechas L., also referred to as French lavender or Spanish lavender, is a well‐known medicinal plant with a strong presence in traditional medicine systems. This review provides an overview of the existing research progress on L. stoechas, encompassing its traditional uses, medicinal phytochemistry, pharmacological activity as well as clinical applications, and in silico studies. Literature searches on the traditional, medicinal phytochemistry and biological activities of L. stoechas were conducted using online databases that included Web of Science, Google Scholar, Scopus, ScienceDirect, and PubMed as well as pre‐electronic literature sources obtained from the library of the university. Recent scientific studies have explored the phytochemicals of L. stoechas, revealing a diverse collection of bioactive substances, including flavonoids, terpenes, and phenolic acids. Pharmacological studies have provided additional clarity on the therapeutic benefits of extracts and isolated components from L. stoechas. Studies confirm its antibacterial, anti‐inflammatory, antioxidant, and neuroprotective effects and its potential for anxiety, insomnia, and dermatological disorders. Computational approaches revealed ligand interactions between L. stoechas constituents and targets, enhancing understanding through in silico analysis. In summary, the combined study underscores L. stoechas’s diverse therapeutic potential, validating its traditional uses while providing scientific insights into its chemical composition, its formulations, its molecular mechanisms, and its pharmacological activities.
TNK2 Inhibitor (R)−9bMS Causes Polyploidization Through Mitotic Failure by Targeting Aurora B
Authors: Murata Mayu , Kuwajima Hiroki , Tanaka Junna , Hasegawa Nanami , Yuki Ryuzaburo , Saito Youhei , Nakayama Yuji 
Published: December 2024

ABSTRACTTNK2 is a ubiquitously expressed nonreceptor‐type tyrosine kinase. TNK2 participates in tumorigenesis, and TNK2 activation has been found in various cancers; therefore, TNK2 is a promising target for cancer chemotherapy. While the TNK2 inhibitor XMD16‐5 is highly selective, it inhibits cytokinesis at higher concentrations by targeting Aurora B kinase, a key enzyme for cell division. Cytokinesis failure frequently generates polyploid cells, and the surviving polyploid cells risk leading to cancer development and malignant progression via chromosome instability. In this study, to investigate the possibility that (R)−9bMS, a TNK2 inhibitor structurally related to XMD16‐5, drives malignant progression by inducing abnormal cell division, we examined its effects on cell division, Aurora B autophosphorylation, and colony formation. Cell count results showed a reduction in the number of A431, HeLa S3, HCT116, and MCF7 cells upon TNK2 inhibitor treatment. Microscopic observation indicated the formation of multinucleated and nucleus‐enlarged cells. An increase in DNA content was confirmed with flow cytometry, which was underpinned by an increased number of centrosomes. Time‐lapse imaging revealed mitotic failure, such as mitotic slippage and cytokinesis failure, as a cause of polyploidization. Of note, TNK2 knockdown significantly increased multinucleated cells, but the effect was quite weak, suggesting that TNK2 inhibition may only partially contribute to mitotic failure and polyploidization. Expectedly, Aurora B phosphorylation was reduced by (R)−9bMS like XMD16‐5, but not by TNK2 knockdown. Collectively, TNK2 inhibitors (R)−9bMS and XMD16‐5 induce polyploidization via mitotic failure caused by the inhibition of Aurora B kinase rather than TNK2. Notably, (R)−9bMS treatment promoted anchorage‐independent colony formation, a hallmark of cancer. Our findings suggest that (R)−9bMS at a high concentration risks promoting cancer development or malignant progression. Therefore, caution should be used when using TNK2 inhibitors for cancers where TNK2 activation is not the transforming mutation and higher concentrations of TNK2 inhibitors are required to slow proliferation.
The Clinical Impact of Mitral Gradient Post Transcatheter Edge‐To‐Edge Repair: A Systematic Review and Meta‐Analysis
Authors: Alabdaljabar Mohamad S. , Almiro Alyaman , Khan Jibran , Gerberi Dana J. , Murad M. Hassan , Thaden Jeremy J. , Rihal Charanjit S. , Eleid Mackram F. 
Published: December 2024

ABSTRACTBackgroundMitral transcatheter edge‐to‐edge repair (TEER) is a minimally invasive therapy for severe mitral regurgitation (MR) in patients with high surgical risk. TEER results in a tissue bridge that decreases mitral valve area, potentially leading to elevated mean gradient. The clinical impact of elevated gradient on outcomes is unclear.MethodsThis systematic review and meta‐analysis was based on a comprehensive search of five databases. We included studies that evaluated post mitral TEER gradient on one of the following outcomes: all‐cause mortality, combined endpoints, symptoms, hospitalizations, and mitral valve re‐intervention. Meta‐analysis was conducted using the random‐effects model.ResultsOut of 6458 citations, 17 studies were included (2017−2024) reporting on 7748 patients. There was significant heterogeneity between studies related to the cutoff used to define elevated gradient, etiology of MR, and outcomes. Elevated mitral gradient post TEER (4, 4.5, 5 mmHg) was associated with worse combined endpoint (HR = 1.35, 95% CI 1.07−1.71; I2 64%), but not all‐cause mortality (HR = 1.25, 95% CI 0.97−1.59; I2 45%) or risk of hospitalization. For the combined endpoint, this association was mainly significant in patients who had mitral gradient assessed using discharge echocardiogram (HR = 1.39, 95% CI 1.07−1.81; I2 62%) for all patients and for those with degenerative MR.ConclusionDespite the heterogeneity between studies, the current analysis suggests that patients with elevated mitral gradient post TEER are at risk of worse clinical outcomes, particularly in patients who had mitral gradient assessed using discharge transthoracic echocardiogram.