bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Molecular Docking and Biological Evaluation of 2- Mercaptomidazoles using Solid Phase Synthesis
Authors: Rani Nidhi , Kumar Praveen , Singh Randhir 
Published: April 2019

Background:
With the increasing resistance and side effects caused due to antifungal agents
there is an urgent need for the new potent antifungal agents with low toxicity profile. Imidazoles have
been used against fungal infections since long time. Further, our previous studies demonstrated that
mercaptoimidazoles possessed good antifungal potency.

Aim and Objective:
This study was aimed to study the antifungal potency of new series of 2-
mercaptoimidazoles.

Materials and Methods:
Eighteen new 2-mercaptoimidazoles containing substituted phenyl group were
synthesized and structures of the synthesized compounds were characterized by spectral studies. The
synthesized compounds were screened for their antifungal potency. Compound 2-(1-(3-hydroxyphenyl)-2-
mercapto-1H-imidazol-4-yl)phenol was found to be the most potent compound among all synthesized
compounds against tested fungal strains. Moreover, all the synthesized compounds were further subjected
to molecular docking study for the inhibition of enzyme 14α-demethylase.

Results:
The in-silico molecular docking study results showed that all the synthesized compounds have
minimum binding energy and good affinity for the active site and may be considered as good inhibitor of
14α-demethylase.

Conclusion:
2-mercaptoimidazoles may be used as potential lead molecules as 14α-demethylase
inhibitors.
Protective Ability of Perovskia abrotanoides Karel Root Extract on the Aggregation of Protein In Vitro
Authors: Puormand Seyed Mahmoud , Ghahghaei Arezou , Valizadeh Jafar , Nazari Shahrzad 
Published: April 2019

Background:
Protein misfolding can lead to aggregation and these protein aggregates are
a fundamental cause of many neurodegenerative disorders such as Alzheimer's, Parkinson's,
Huntington's, Prion disease and amyotrophic lateral sclerosis. In recent years, a wide variety of
natural compounds have been investigated as protein aggregation inhibitors. Many investigations
have reported the therapeutic effects of botanicals constituents and their derivatives in neurodegenerative
diseases.

Objective:
In this study, we examined the effect of Perovskia abrotanoides Karel (P. abrotanoides)
root extract on the 1,4-dithiothreitol (DTT)-induced aggregation of proteins.

Methods:
The anti-aggregation ability of P. abrotanoides root extract was studied using visible absorption
spectroscopy (light scattering), fluorescence spectroscopy, and circular dichroism (CD)
spectroscopy.

Results:
The protective effect of P. abrotanoides root extract was varied in the three different-sized
proteins (insulin, α-lactalbumin, and ovotransferrin).

Conclusion:
The results showed that P. abrotanoides root extract was able to inhibit protein aggregations
in a concentration-dependent manner due to the interaction of P. abrotanoides root extract
with hydrophobic area of proteins.
Desain kurikulum literasi media berlandaskan nilai-nilai Islam di sekolah menengah atas Al Irsyad Satya
Authors: Kurniasari Rani , Kurniawan Deni 
Published: April 2019

Globalisasi sebagai sebuah bahasan kontemporer menjadikan dunia menjadi seolah berbaur tanpa sekat. Sisi positifnya, kemudahan mengakses media atau informasi dari berbagai belahan dunia menjadikan semakin bervariasinya cara untuk memudahkan kehidupan manusia. Namun sebagai konsekuensi negatif, berbagai budaya atau paham seperti kapitalisme dan hedonisme, kini menjadi budaya yang marak ada di masyarakat kita. Penelitian ini dilatarbelakangi oleh pentingnya kompetensi literasi media bermuatan nilai-nilai Islam pada kegiatan ekstrakurikuler Pengembangan Diri (PD) di SMA Al-Irsyad Satya. Tujuan yang hendak dicapai melalui penelitian ini adalah dihasilkannya desain kurikulum literasi media bermuatan nilai-nilai Islam yang relevan pada kegiatan ekstrakurikuler PD di SMA Al-Irsyad Satya. Metode dalam penelitian ini adalah Design & Development dengan pendekatan kuantitatif. Desain kurikulum menghasilkan dokumen kurikulum literasi media bermuatan nilai-nilai Islam pada kegiatan ekstrakurikuler PD yang terdiri dari 27 tujuan pembelajaran, 21 materi/ konten pembelajaran, 17 strategi/ pengalaman belajar, dan 6 evaluasi pembelajaran. Pendapat stakeholder, dokumen kurikulum literasi media bermuatan nilai-nilai Islam pada kegiatan ekstrakurikuler PD di SMA Al-Irsyad Satya yang disusun layak untuk dipergunakan di SMA Al-Irsyad Satya karena memiliki relevansi yang memadai baik secara internal maupun eksternal. Kata kunci: Kurikulum Literasi Media, D & D, Literasi Media Bermuatan Nilai-Nilai Islam.
Evaluación diagnóstica como estrategia para el fortalecimiento del aprendizaje en el Bachillerato General por Áreas Interdisciplinarias de la Universidad de Guadalajara
Authors: Martínez Favela Francia Carmen , Vázquez Ochoa Sara 
Published: April 2019

<p>La identificación objetiva de las áreas de oportunidad necesarias para satisfacer las demandas de aprendizaje de los estudiantes de nuevo ingreso al Bachillerato General por Áreas Interdisciplinarias (BGAI) de la Universidad de Guadalajara constituye el primer paso en el proceso de mejora del programa, considerando que solo a través de resultados sólidos es posible implementar estrategias de mejora coherentes. </p><p>En este artículo se muestra el proceso de investigación realizado por la Dirección de Educación Continua, Abierta y a Distancia (DECAD) como el primer paso para fortalecer el aprendizaje en la población que accede a esta oferta educativa.</p>
Brave new world: literatura e tecnologias digitais no ensino de lí­ngua inglesa
Authors: Rodrigues Jessica Tomimitsu , Motter Rose Maria Belim 
Published: April 2019

O presente trabalho propõe refletir sobre a validade e eficiência de uma proposta pedagógica para o ensino de lí­ngua inglesa em salas de aulas regulares que une a Literatura e as Tecnologias Digitais. Em concomitância com a análise, discorre-se a respeito do papel do texto literário no desenvolvimento humano (LIMA, 2009), a proposta da Literatura na sala de aula (BORDINI; AGUIAR, 1993 e KLEIMAN, 1996), o ciberespaço e sua relação com a literatura (MURRAY, 2003) e uma proposta literária-cibernética para o ensino-aprendizagem de lí­ngua inglesa (BRENNER, 2014 e CHINNERY, 2014) para os chamados nativos digitais (PRENSKY, 2001). Analisar-se-á, também, o status do inglês como lí­ngua internacional, intrinsecamente ligado í s relações de poder, polí­ticas, econômicas e também identitárias; refletindo, portanto, nas propostas de ensino-aprendizagem para domí­nio fluente do idioma. Nesse sentido, a obra que intitula o trabalho, livro de excelência de Aldous Huxley e também versos shakespearianos, Brave New World, propõe um rompimento com as barreiras impostas bem como um incentivo à mudança, inovadora com as tecnologias e emancipadora com a literatura, na prática pedagógica de ensino de lí­ngua inglesa.
A Recontextualização na mí­dia: uma análise linguí­stico-discursiva da divulgação cientí­fica nos sites G1 e Hypescience
Authors: Pereira Wilma Maria 
Published: April 2019

Um dado marcante no atual processo de circulação da informação procedente do âmbito cientí­fico na sociedade moderna é o tratamento dado í s informações com o objetivo de alcançar um número cada vez maior de pessoas. Isso ocorre porque o enunciador que tenciona divulgar uma informação de caráter cientí­fico para o grande público deve buscar torná-la mais próxima do cotidiano das pessoas para que essa informação pareça relevante para suas vidas. Nesse sentido, é possí­vel notar que, além das estratégias linguí­stico-discursivas, os textos de divulgação cientí­fica voltados à popularização da ciência têm feito uso de várias estratégias com o intuito de tornar as informações mais atrativas para seus leitores. O objetivo desse artigo é investigar a articulação entre as estratégias divulgativas e as técnicas argumentativas utilizadas no processo de recontextualização da informação a fim de verificar o seu funcionamento na construção do sentido dos textos divulgativos nas mí­dias on line G1 e HypeScience. Para fins analí­ticos, foram adotados os pressupostos teórico-metodológicos da Análise do Discurso de Divulgação Cientí­fica e as técnicas argumentativas propostas por Olbrechts-Tyteca (1996). A análise apontou que o site G1 buscou divulgar a informação de forma mais objetiva e cientí­fica, ao passo que o site Hypescience lançou mão de modalizadores argumentativos com o intuito de orientar o leitor para determinada conclusão.
A CONSTRUÇÃO JURÍDICA DA INTERAÇÃO SEXUAL: HIERARQUIA VALORATIVA E PUNITIVA NA LEGISLAÇAO PENAL PORTUGUESA
Authors: Faustino Maria João 
Published: April 2019

O presente artigo propõe uma análise sociojurídica dos atos sexuais com relevância penal, consagrados na legislação penal em curso no contexto jurídico português. A partir do mapeamento da legislação em vigor e do enquadramento doutrinário que lhe concerne, procedeu-se à identificação das categorias, conceitos e representações fundamentais da criminalidade sexual, procurando a deteção do fundo normativo concernente à interação sexual juridicamente consagrada.
Procedendo à inquirição e análise crítica de tais categorias e distinções fundamentais, defendo que a criminalidade sexual aponta para uma conceção fisicalista, gradativa e piramidal do corpo sexualizado e da agressão sexual. O escalonamento valorativo é erguido pela hierarquização dos atos criminalmente previstos: contactos de natureza sexual; atos sexuais de relevo e atos sexuais de especial relevo. A construção piramidal da sexualidade tem como paradigma e expoente referencial a penetração vaginal, correspondendo ao conceito de ‘imperativo coital’.
Religious Identity and National Conflict in the 20th Century Indonesia
Authors: Jonathan Andreas 
Published: April 2019

This study attempts to discuss on how religious identities contribute to or was in conflict with the emerging national identities, with focusing issue on the struggle of Islam in its relation to Indonesian identity as a multi-religious nation and Pancasila state. Based on the critical analysis from the various literature, the result of the study showed that Islam did both contribute and was in conflict with the Indonesian national identity. The Islamist fights for the Islamic state, the nationalist defends Pancasila state. As long as Islam is the majority in Indonesia and as long as there is diversity in Islam, especially in the interpretation of Islam and the state, Indonesian national identity will always be in conflict between Pancasila state and Islamic state. Even though, the role of religion in society and nation change is very significant. The Islamist is always there, although it is not always permanent in certain organizations. In the past, NU and Muhammadiyah were considered as Islamist, but today they are nationalist. At the same time, new Islamist organizations and parties emerge to continue their Islamist spirit.Â Keywords: Islam, Religious identity, Pancasila,Â
PENGARUH BAHAN PENGEKSTRAK TERHADAP KARAKTERISTIK EKSTRAK SENYAWA FUNGSIONAL DARI KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)
Authors: Achyadi Nana Sutisna 
Published: April 2019

The purpose of this study is to determine the use of extracting materials suitable for dragon fruit skin extraction so that the functional compound (anthocyanin) obtained optimally. The research method consisted of preliminary research and main research. Preliminary research was conducted to determine the maceration method (maceration and maceration modification with agitator) to be used in the main research and raw material analysis. The main research is conducted to determine the appropriate extracting agent (various types of acids and mixtures). The experimental design used in the study was Randomized Block Design (RAK) with 1x6 factorial pattern with 4 replications. Response variable in this research is physical response include analysis of dye and calculation of rendement and chemical response which include determination of acidity level (pH), vitamin C content analysis, water content analysis, and antioxidant activity analysis. The result of preliminary research is obtained that the maceration method chosen is the usual maceration method and the result of raw material analysis which includes the vitamin C level of 184,937 mg vitamin C / 100 gram sample; analysis of dye where L * 37.56 a * 9.29 b * -0.31; and acidity level (pH) 4.73. While based on the results from the main study obtained that the selected extracting material is 2% tartrate (w / v). Response result obtained that is yield 19,09%; dye analysis with L* 48,12 a * 31.02 and b * 2,70; acidity level (pH) 0.73; rate of water 6,3%; vitamin C levels of 167.63 mg vitamin C / 100 gram samples; as well as antioxidant activity of 10,242.83 ppm.
HUBUNGAN PENGETAHUAN GIZI, POLA KONSUMSI DAN RAIHAN NILAI PADA MATAKULIAH ILMU GIZI PANGAN MAHASISWA PRODI TEKNOLOGI PANGAN FAKULTAS TEKNIK UNPAS BANDUNG
Authors: Sumartini Sumartini 
Published: April 2019

Mahasiswa merupakan sumber daya manusia untuk pembangunan di masa mendatang. Untuk meningkatkan kualitas sumber daya manusia banyak faktor yang mempengaruhi. Salah satu faktor penting untuk menjaga kualitas hidup manusia yang optimal adalah kesehatan dan gizi, sedangkan kualitas sumber daya manusia digambarkan melalui pertumbuhan ekonomi, usia, harapan hidup dan tingkat pendidikan. Tujuan dari penelitian ini adalah untuk mengetahui hubungan pengetahuan gizi, pola konsumsi dan raihan nilai pada matakuliah ilmu gizi pangan pada mahasiswa Program Studi Teknologi Pangan FT UNPAS Bandung. Penelitian ini diharapkan dapat meningkatkan pola konsumsi sesuai dengan pengetahuan gizi sehingga siswa dapat memperoleh status gizi ideal dan meningkatkan kesadaran akan kebiasaan makan yang baik di Program Studi Teknologi Pangan FT UNPAS Bandung. Penelitian ini merupakan penelitian cross sectional analitik dengan menggunakan pengetahuan gizi, pola konsumsi dan status gizi sebagai variabel. Total populasi adalah 300 mahasiswa Program Studi Teknologi Pangan FT UNPAS yang mengambil matakuliah ilmu gizi pangan Bandung. Sampel sebanyak 175 siswa ditentukan dengan teknik purposive sampling. Data dikumpulkan dengan menggunakan kuesioner pengetahuan gizi dan Food Frequency Questionnaire (FFQ). Data tabulasi dan analisis data disajikan dalam persentase dan analisis korelasi dengan metode Chi Square. Berdasarkan penelitian menunjukkan: (1) ada hubungan antara pengetahuan gizi dengan status gizi, (2) ada hubungan antara pola konsumsi dengan status gizi, (3) ada hubungan antara pengetahuan gizi dan pola konsumsi dengan status gizi pada mahasiswa (4) ada hubungan antara raihan nilai dengan status gizi, pada mahasiswa Program Studi Teknologi Pangan FT UNPAS dan jajanan yang ada di kampus IV UNPAS sudah memenuhi asupan gizi untuk makanan siang mahasiswa Program Studi Teknologi Pangan FT UNPAS.
Democracia deliberativa, cidadania e gestão social
Authors: Vital Adriano Fraga Rodrigues , Fernandes Rebeca Vasconcelos , Cançado Airton Cardoso , Rodrigues Waldecy 
Published: April 2019

Os conselhos gestores, estimulados após a promulgação Constituição de 1988, devem ser ancorados na democracia e na efetiva deliberação participativa. O presente artigo objetiva identificar a presença dos Critérios de Cidadania Deliberativa e Gestão Social no Conselho Municipal de Trânsito, Transportes e Segurança de Gurupi (COMTTSG), criado em 27 de março de 2015 pela Lei Municipal n° 2.206, como órgão de controle social de gestão das políticas de trânsito do Município. A metodologia utilizada nesta pesquisa foi análise qualitativa, baseada em observações em reuniões do COMTTSG; sete entrevistas semiestruturadas; e questionários com o mesmo público. Verificou-se que apesar de algumas fragilidades quanto às dimensões da Cidadania Deliberativa e da Gestão Social dispostas neste trabalho, os números dos acidentes de trânsito demonstram que mudanças estão ocorrendo no município, o que pode demonstrar que efetivas ações no gerenciamento das políticas públicas no âmbito do trânsito de Gurupi estão em curso.
Palavras-Chave: Conselhos Gestores. Cidadania Deliberativa. Gestão Social. Trânsito. Políticas Públicas.
Estado Neoliberal y des ciudadanización
Authors: Moreno Hernández Hugo César 
Published: April 2019

El objetivo principal del artículo es discutir la noción de desciudadanización a través de las aportaciones de Giorgio Agamben y Achille Mbembe observando los procesos de ilegalización de la migración y la criminalización de sectores sociales como única herramienta de acercamiento a poblaciones marginadas mediante el análisis de los tres pilares del Estado contemporáneo, según Agamben: el estado de excepción, el campo y la nuda vida, para comprender cómo opera la tanatopolítica. En segunda instancia, se observa, por un lado, la aparición de agentes no estatales que imponen orden y aseguran ganancias económicas ejerciendo necropolítica, por parte, la forma en que las pandillas transnacionales en El Salvador lo hacen en territorios donde se asientan, buscando los puntos en común que permitirán pensar el gobierno privado indirecto como un efecto “natural” del Estado neoliberal, es decir, como resultado de la privatización de la seguridad pública.
Palabras clave: Desciudadanización. Biopolítica. Tanatopolítica. Necropolítica.
Erythropoietin Resistance in Hemodialysis Patients
Authors: Jacović Saša , Jovanović Milena , Hamzagić Nedim , Pavlović Radiša , Petrović Dejan 
Published: April 2019

Summary
Anemia is defined as blood hemoglobin concentration of less than 120 g/l in women and less than 130 g/l in men. The main cause of the development of anemia in patients treated with regular hemodialysis is the lack of endogenous erythropoietin, and its main clinical consequences are: progressive decline in residual renal function, development of cardiovascular disorders, disorders of cognitive functions and a decrease in the quality of life of these patients. Despite the administration of an appropriate dose of erythropoietin, in 5-10% of patients treated with regular hemodialysis, there is resistance to erythropoietin activity. The main risk factors for the development of resistance to the effects of erythropoietin are: iron deficiency, microinflammation, deficiency of vitamin D, secondary hyperparathyroidism, deficiency of vitamin C, and inadequate hemodialysis. The main side effects of erythropoietin are: hypertension, thrombosis of the vascular approach to hemodialysis, and the red blood cell precursor aplasia in the bone marrow. Early detection and elimination of risk factors, optimization and indi-vidualization of hemodialysis prescription prevent the development of resistance to erythropoietin activity, enable the achievement of target blood hemoglobin, reduce the development of cardiovascular morbidity, and improve the quality of life of these patients.
Epidemiology of Influenza in Patients with Acute Lower Respiratory Tract Infection in South of Iran (2015-2016)
Authors: Rahmanian Vahid , Shakeri Masihollah , Shakeri Heshmatollah , Jahromi Abdolreza Sotoodeh , Bahonar Alireza , Madani Abdolhossein 
Published: April 2019

Summary
Influenza is of particular importance because of the pace of epidemics, the extent and number of infected people, and the severity of the side effects. The aim of this study was to investigate the epidemiological and clinical aspects of this disease during the last epidemic in southern Iran.
The present cross-sectional study was performed on the basis of secondary data analysis and information in medical records of patients with acute lower respiratory system infection in hospitals affiliated to Jahrom University of Medical Sciences. Data were analyzed by SPSS 18 using descriptive statistics, Chi-square test and logistic regression at 0.05 significance level.
From 1st September 2015 to 20th March 2016, 108 patients with acute lower respiratory tract infection with a mean age of 42.92 ± 19.65 years were admitted to Jahrom hospitals, of which 43 were diagnosed with definite influenza, all of which (100%) had H1N1 type A influenza. There were eight deaths in all, of which five were positive for H1N1, and of these five cases, three cases had delayed diagnosis and treatment, and four cases had underlying diseases. The results of multivariate logistic regression analysis showed a significant relationship between positive H1N1 cases and history of contact with definite influenza, traveling abroad, and clinical symptoms of chills (p < 0.05).
The results of this study showed that 39.81% of the patients with acute lower respiratory tract infections suffered from influenza. Furthermore, the delayed treatment and the underlying diseases were the most important cause of death.
Multi-invertible maps and their applications
Authors: Ślosarski Mirosław 
Published: April 2019

Abstract
In this article, we define multi-invertible, multivalued maps. These mappings are a natural generalization of r-maps (in particular, the singlevalued invertible maps). They have many interesting properties and applications. In this article, the multi-invertible maps are applied to the construction of morphisms and to the theory of coincidence.
Future Biotechnology
Authors: Dundar Munis , Prakash Satya , Lal Ratnesh , Martin Donald K. 
Published: April 2019

Abstract
The field of biotechnology is large and could be considered tritely as simply the development of technology that is based on biology. It is clear that the concepts of biotechnology can spread to cover many different fields of application and so the future developments in biotechnology will be similarly wide-ranging across many fields of applications. Here we focus onto medical biotechnology and further refine our discussion onto considering aspects of genetics and nanotechnologies that could impact on the development of future biotechnologies in the medical field. These areas that we consider in this brief article provide the basis for a panel discussion on Future Biotechnology at the European Biotechnology Congress held in Valencia, Spain in April 2019.
Anti-inflammatory and analgesic activities of methanol extract of Helianthus annuus Linn. (Asteraceae) leaf
Authors: Onoja Samuel O. , Onyebuchi Glory C. , Ijeh Ifeoma I. , Ezeja Maxwell I. 
Published: April 2019

Abstract
This study evaluate the anti-inflammatory and analgesic properties of Helianthus annuus Linn. in rats. Methanol extract of Helianthus annuus (HAE) leaf was used in this study. Formalin- and egg-albumin induced-paw edema were used to investigate the anti-inflammatory activities while acetic acid-induced writhing reflex and tail flick models were used to evaluate the analgesic properties. The doses of HAE used were 150, 300 and 600 mg/kg. Acetylsalicylic acid (ASA) was used as reference drug in the anti-inflammatory and writhing reflex models while pentazocine (reference drug) was used in tail flick model. The negative control was dosed 5% tween-20 (10 ml/kg). The HAE exhibited significant (P < 0.05) dose-dependent anti-inflammatory and analgesic activities. At 3 hour (h) post treatment, the HAE (300 mg/kg) produced 33.33% and 32.94% while ASA produced 36.36% and 35.29% reduction in paw volume in the formalin and egg-albumin induced paw edema models respectively when compared with negative control. In the acetic acid-induced writhing reflex, ASA and HAE (600 mg/kg) produced 67.89% and 35.78% reduction in the number of writhing, respectively when compared with the negative control. Pentazocine and HAE (300 mg/kg) caused 67.62% and 35.24% increase in pain reaction time when compared with the negative control. The study affirms the folkloric uses of Helianthus annuus in the management of pain and inflammation.