bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coherent spin dynamics of electrons and holes in CsPbBr3 perovskite crystals
Authors: Belykh Vasilii V. , Yakovlev Dmitri R. , Glazov Mikhail M. , Grigoryev Philipp S. , Hussain Mujtaba , Rautert Janina , Dirin Dmitry N. , Kovalenko Maksym V. , Bayer Manfred 
Published: February 2019

AbstractThe lead halide perovskites demonstrate huge potential for optoelectronic applications, high energy radiation detectors, light emitting devices and solar energy harvesting. Those materials exhibit strong spin-orbit coupling enabling efficient optical orientation of carrier spins in perovskite-based devices with performance controlled by a magnetic field. Here we show that elaborated time-resolved spectroscopy involving strong magnetic fields can be successfully used for perovskites. We perform a comprehensive study of high-quality lead halide perovskite CsPbBr3 crystals by measuring the exciton and charge carrier g-factors, spin relaxation times and hyperfine interaction of carrier and nuclear spins by means of coherent spin dynamics. Owing to their ‘inverted’ band structure, perovskites represent appealing model systems for semiconductor spintronics exploiting the valence band hole spins, while in conventional semiconductors the conduction band electrons are considered for spin functionality.
A new high-resolution melting analysis for the detection and identification of Plasmodium in human and Anopheles vectors of malaria
Authors: Murillo Enderson , Muskus Carlos , Agudelo Luz A. , Vélez Iván D. , Ruiz-Lopez Freddy 
Published: February 2019

AbstractAmong vector-borne diseases malaria is the leading cause of morbidity in the world, with more than 200 million cases per year and a large number of deaths. The techniques traditionally used for the detection of Plasmodium in humans and Anopheles mosquitoes include microscopy, IRMA, ELISA, antibody or molecular assays, and anopheline dissection. However, these techniques are limited by their requirement of skilled personnel, low sensitivity or long processing times. A PCR-based high-resolution melting (PCR-HRM) analysis was developed for the detection and identification of P. falciparum, P. vivax and P. malariae that infect humans and Anopheles. In 41 human samples PCR-HRM detected 14 samples positive for P. vivax, 17 for P. falciparum, three for P. malariae, three mixed infections for P. vivax/P. malariae and four negative samples. Whereas benchmarking assays of microscopy and nested PCR had false positive detections. Additionally, PCR-HRM was able to detect natural infection with Plasmodium spp. in An. darlingi and An. mattogrossensis. The PCR-HRM presented is the first single assay developed for the detection and identification of P. vivax, P. falciparum and/or P. malariae in human and Anopheles. This method improves on currently available assays as it is easy-to-use, rapid, sensitive and specific with a low risk of contamination.
Alkali treated antioxidative crude polysaccharide from Russula alatoreticula potentiates murine macrophages by tunning TLR/NF-κB pathway
Authors: Khatua Somanjana , Acharya Krishnendu 
Published: February 2019

AbstractIn our previous research, Russula alatoreticula was demonstrated as a novel species, ethnic myco-food and reservoir of hot water extractable polysaccharides. However, residue after the hydrothermal process still offer plenty of medicinal carbohydrates that could easily be extracted by using alkali solvent. Thus, the present work was attempted to prepare crude polysaccharide using remainder of the conventional method and subsequently a β-glucan enriched fraction, RualaCap, was isolated. The bio-polymers displayed pronounced therapeutic efficacy as evident by radical scavenging, chelating ability, reducing power and total antioxidant capacity. In addition, strong immune-enhancing potential was also observed indicated by augmentation in macrophage viability, phagocytic uptake, nitric oxide (NO) production and reactive oxygen species (ROS) synthesis. Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-κB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α, Iκ-Bα, interferon (IFN)-γ and interleukin (IL)-10 genes explaining mode of action. Taken together, our results signify possibility of RualaCap as a potent nutraceutical agent and enhance importance of R. alatoreticula especially in the field of innate immune stimulation.
Circulating Hematopoietic Stem/Progenitor Cells are Associated with Coronary Stenoses in Patients with Coronary Heart Disease
Authors: Zhu Fu-Li , Zhang Ning , Ma Xiao-Juan , Yang Jing , Sun Wei-Ping , Shen Yi-Qing , Wen Yu-Mei , Yuan Sha-Sha , Zhao Dong , Zhang Hai-Bin , Feng Ying-Mei 
Published: February 2019

AbstractInflammatory cells in atherosclerotic plaque exclusively originate from hematopoietic stem/progenitor cells (HSPCs). In this study, we investigated whether circulating HSPCs frequency related to coronary stenosis in patients with coronary heart disease (CHD). Coronary angiography was performed in 468 participants who were recruited at Cardiology Centre in LuHe Hospital from March 2016 to May 2017. Among these subjects, 344 underwent echocardiography. Mononuclear cells isolated from peripheral blood were stained with an antibody cocktail containing anti-human CD34, anti-human lineage, anti-human CD38, and anti-human CD45RA. Lineage−CD38−CD45RAdimCD34+HSPCs were quantified by flow cytometry. CHD was defined as coronary stenosis ≥50% and the extent of CHD was further categorised by coronary stenosis ≥70%. A p < 0.0031 was regarded statistically significant by the Bonferroni correction. Circulating HSPCs frequency was 1.8-fold higher in CHD patients than non-CHD participants (p = 0.047). Multivariate-adjusted logistic analysis demonstrated that HSPCs was the only marker that was associated with the odds ratio of having mild vs. severe coronary stenosis (2.08 (95% CI, 1.35–3.21), p = 0.0009). Left ventricular ejection fraction was inversely correlated with HSPCs frequency and CRP in CHD patients (p < 0.05 for both). In conclusion, HSPCs frequency in circulation is intimately related to coronary stenoses in CHD patients.
Low-power phonon lasing through position-modulated Kerr-type nonlinearity
Authors: Djorwe P. , Pennec Y. , Djafari-Rouhani B. 
Published: February 2019

AbstractWe demonstrate low-power amplification process in cavity optomechanics (COM). This operation is based on the nonlinear position-modulated self-Kerr interaction. Owing to this nonlinear term, the effective coupling highly scales with the photon number, resulting in a giant enhancement of the cooperativity. Even for small nonlinearity, the system reaches the amplification threshold for weak driving strength, leading to low-power phonon lasing. This amplifier can be phase-preserving and provides a practical advantage related to the power consumption issues. This work opens up new avenues to perform low-power and efficient amplifiers in optomechanics and related fields.
Alamandine attenuates arterial remodelling induced by transverse aortic constriction in mice
Authors: de Souza-Neto Fernando Pedro , Silva Mario de Morais e , Santuchi Melissa de Carvalho , de Alcântara-Leonídio Thaís Cristina , Motta-Santos Daisy , Oliveira Aline Cristina , Melo Marcos Barrouin , Canta Giovanni Naves , de Souza Leandro Eziquiel , Irigoyen Maria Cláudia Costa , Campagnole-Santos Maria José , Guatimosim Silvia , Santos Robson Augusto Souza , da Silva Rafaela Fernandes 
Published: February 2019

Abstract
Aims: The renin–angiotensin system (RAS) plays an important role in the pathophysiology of vascular diseases, especially as a mediator of inflammation and tissue remodelling. Alamandine (Ala1-angiotensin-(1-7)) is a new biologically active peptide from the RAS, interacting with Mas-related G-protein-coupled receptor member D. Although a growing number of studies reveal the cardioprotective effects of alamandine, there is a paucity of data on its participation in vascular remodelling associated events. In the present study, we investigated the effects of alamandine on ascending aorta remodelling after transverse aortic constriction (TAC) in mice. Methods and results: C57BL/6J male mice were divided into the following groups: Sham (sham-operated), TAC (operated) and TAC+ALA (operated and treated with alamandine-HPβCD (2-Hydroxypropyl-β-cyclodextrin), 30 μg/kg/day, by gavage). Oral administration of alamandine for 14 days attenuated arterial remodelling by decreasing ascending aorta media layer thickness and the cells density in the adventitia induced by TAC. Alamandine administration attenuated ascending aorta fibrosis induced by TAC, through a reduction in the following parameters; total collagen deposition, expression collagen III and transforming growth factor-β (TGF-β) transcripts, matrix metalloproteinases (MMPs) activity and vascular expression of MMP-2. Importantly, alamandine decreased vascular expression of proinflammatory genes as CCL2, tumour necrosis factor α (TNF-α) and interleukin-1β (IL-1β), and was able to increase expression of MRC1 and FIZZ1, pro-resolution markers, after TAC surgery. Conclusion: Alamandine treatment attenuates vascular remodelling after TAC, at least in part, through anti-fibrotic and anti-inflammatory effects. Hence, this work opens new avenues for the use of this heptapeptide also as a therapeutic target for vascular disease.
Comparative Validity of the American Speech-Language-Hearing Association's National Outcomes Measurement System, Functional Oral Intake Scale, and G-Codes to Mann Assessment of Swallowing Ability Scores for Dysphagia
Authors: Dungan Sarah , Gregorio David , Abrahams Theodore , Harrison Baylee , Abrahams Julia , Brocato Destinee , Davis Catherine , Espana Emily , Garcia Rachel , Smith Shanara , Taylor Bryn , Higgins Tiphanie , Daley Leon , Carnaby Giselle 
Published: February 2019

Background
The American Speech-Language-Hearing Association (ASHA) advocates using the National Outcomes Measurement System (NOMS) scales to assist speech-language pathologists (SLPs) in the mandated assigning of “functional limitation levels” and G-Code for Medicare Part B claims. Unfortunately, not all SLPs have access to this tool, and it is unclear how other common outcome measurement scales relate to ASHA NOMS or G-Codes. To explore the utility of other scales in reporting Centers for Medicare & Medicaid Services G-Codes, we conducted a comparative validity study comparing ASHA NOMS Dysphagia Scale, Functional Oral Intake Scale (FOIS), and Mann Assessment of Swallowing Ability to G-Codes on a sample of 105 patients who had stroke.

Method
Nine SLP student researchers trained to criterion on the NOMS and FOIS blindly and independently scored 105 stroke cases with dysphagia de-identified from a past study. Three graduate SLP clinicians independently assigned G-Codes. Data from the student researchers and Mann Assessment of Swallowing Ability scores were compared for admission and discharge from subacute rehabilitation. Analysis included intraclass correlation for reliability, Spearman correlation for comparative validity, and area under the receiver operating characteristic curve to compare the validity and discriminatory utility of measures in classifying dysphagia.

Results

Strong correlations (> .6) were noted between all measures at baseline, particularly FOIS and NOMS coding (
r
= .919). At discharge, superior performance by the FOIS (area under the receiver operating characteristic curve = 0.819) was demonstrated. Code missingness was higher for the NOMS than the other scales.

Discussion
All 3 clinical dysphagia tools demonstrate acceptable validity in supporting G-Code designation to stroke cases. The FOIS demonstrated superior validity and utility across time points. The NOMS Dysphagia Scale was significantly affected by data missingness due to the multiconstruct nature of the tool.
Age determination for 269 Gaia DR2 open clusters
Authors: Bossini D. , Vallenari A. , Bragaglia A. , Cantat-Gaudin T. , Sordo R. , Balaguer-Núñez L. , Jordi C. , Moitinho A. , Soubiran C. , Casamiquela L. , Carrera R. , Heiter U. 
Published: February 2019

Context. The Gaia Second Data Release provides precise astrometry and photometry for more than 1.3 billion sources. This catalog opens a new era concerning the characterization of open clusters and test stellar models, paving the way for better understanding of the disk properties.
Aims. The aim of the paper is to improve the knowledge of cluster parameters, using only the unprecedented quality of the Gaia photometry and astrometry.
Methods. We have made use of the membership determination based on the precise Gaia astrometry and photometry. We applied an automated Bayesian tool, BASE-9, to fit stellar isochrones on the observed G, GBP, GRP magnitudes of the high probability member stars.
Results. We derive parameters such as age, distance modulus, and extinction for a sample of 269 open clusters, selecting only low reddening objects and discarding very young clusters, for which techniques other than isochrone-fitting are more suitable for estimating ages.
Beurteilung der Tubenfunktionsstörung mit dem
ETDQ-7
Authors: Todt Ingo 
Published: February 2019

Harju T et al. Eustachian Tube Dysfunction–Related Symptoms in Chronic Nasal
Obstruction Caused by Inferior Turbinate Enlargement. Ann Otol Rhinol Laryngol
2017; 126: 798–803
Ärzte des Universitätskrankenhauses von Tampere, Finnland, beurteilten den
Zusammenhang zwischen chronischer Nasenverstopfung durch Vergrößerung der
unteren Nasenmuschel und Symptomen, die durch eine Eustachi-Tubendysfunktion
bedingt sind, mit Hilfe des „Eustachian Tube Dysfunction Questionnaire“
(ETDQ-7) als Instrument zur Evaluation einer Tubenfunktionsstörung.
The Effect of Pedaling Cadence on Skeletal Muscle Oxygenation During Cycling at Moderate Exercise Intensity
Authors: Formenti Federico , Dockerill Cameron , Kankanange Lasitha , Zhang Luyu , Takaishi Tetsuo , Ishida Koji 
Published: February 2019

AbstractThe aim of this study was to assess the changes determined by increased cadence on skeletal muscle oxygenation during cycling at an exercise intensity equal to the ventilatory threshold (Tvent).Nine healthy, active individuals with different levels of cycling experience exercised at a power output equal to Tvent, pedaling at cadences of 40, 50, 60, 70, 80 and 90 rpm, each for 4 min. Cadences were tested in a randomized counterbalanced sequence. Cardiopulmonary and metabolic responses were studied using an ECG for heart rate, and gas calorimetry for pulmonary oxygen uptake and carbon dioxide production. NIRS was used to determine the tissue saturation index (TSI), a measure of vastus lateralis oxygenation.TSI decreased from rest to exercise; the magnitude of this TSI reduction was significantly greater when pedaling at 90 rpm (−14±4%), compared to pedaling at 40 (−12±3%) and 50 (−12±3%) rpm (P=0.027 and 0.017, respectively). Albeit small, the significant decrease in ΔTSI at increased cadence recorded in this study suggests that skeletal muscle oxygenation is relatively more affected by high cadence when exercise intensity is close to Tvent.
Electronically Divergent Triscyclometalated Iridium(III) 2-(1-naphthyl)pyridine Complexes and Their Application in Three-Component Methoxytrifluoromethylation of Styrene
Authors: Njogu Rachael , Fodran Peter , Tian Yuxi , Njenga Lydia , Kariuki David , Yusuf Amir , Scheblykin Ivan , Wendt Ola , Wallentin Carl-Johan 
Published: February 2019

A systematic study of the photophysical and electrochemical properties of triscyclometalated homoleptic iridium(III) complexes based on 2-(1-naphthyl)pyridine (npy) ligands is presented. A systematic investigation of ligand substitution patterns showed an influence on the lifetime of the excited state, with slight changes in the absorption and emission spectral features. Specifically, the emission lifetime of a complex of an npy ligand substituted with a strongly electron-withdrawing trifluoromethyl group was longer than that of the corresponding complex with the electronically nonperturbed ligand (3.7 μs versus 1.5 μs). Electronically complementary ligands and complexes with ­orthogonal configurations showed slightly shorter excited state lifetimes compared with unsubstituted npy (1.4–3.0 μs). All complexes displayed reversible or quasireversible redox-couple processes, with the complex of the trifluoromethylated ligand showing the highest ground-state oxidation potential E1/2
ox [Ir(III)/Ir(IV) = 0.95 V vs. SCE in CH2Cl2]. This study showed that these complexes can be used as efficient photoredox catalysts, as demonstrated by their application in a regioselective methoxytrifluoromethylation in which the npy complexes showed equal or better performance compared with the archetypical photo­redox catalyst tris[2-phenylpyridinato]iridium(III).
Is Intraoperative Fluoroscopy Necessary to Confirm Device Position for Femoral-Sided Cortical Suspensory Fixation during Anterior Cruciate Ligament Reconstruction?
Authors: Balldin B. Christian , Nuelle Clayton W. , DeBerardino Thomas M. 
Published: February 2019

AbstractIncreased laxity within the graft construct system can lead to graft failure after anterior cruciate ligament (ACL) reconstruction. Suboptimal cortical device positioning could lead to increased laxity within the system, which could influence the mechanics and function of the graft reconstruction. This study evaluates the benefit of intraoperative fluoroscopy to confirm device position on the femur during ACL reconstruction using cortical suspensory fixation. One hundred consecutive patients who underwent soft tissue ACL reconstruction using a suspensory cortical device for femoral fixation were retrospectively evaluated. Patients were split into two groups: Group A utilized anteromedial portal visualization and had intraoperative fluoroscopic imaging performed at the time of ACL graft fixation to confirm femoral device placement on the lateral femoral metaphyseal cortex. Group B utilized anteromedial portal visualization alone. Both groups had radiographic X-rays performed at the first postoperative visit to evaluate device location and all images were independently evaluated by three fellowship trained orthopaedic surgeons. Device position was classified as optimal if there was complete apposition of the entire device against the femoral cortex and suboptimal if it was > 2 mm off the cortex. Fisher's exact test, analysis of variance, and 95% confidence intervals were calculated to compare the groups for statistical significance. The results showed 0/60 (0%) patients in group A had suboptimal device position at postoperative follow-up, while 4/40 (10%) patients in group B had suboptimal device position (p = 0.013). There were no graft failures in group A and one graft failure in group B. There was a significant difference in cortical device position in patients who had intraoperative fluoroscopic imaging versus patients who had no intraoperative imaging. The use of confirmatory intraoperative imaging may be beneficial to confirm appropriate device location when using a femoral cortical suspensory fixation technique for ACL reconstruction.
Torsional Osteotomy
Authors: Schröter Steffen , Nakayama Hiroshi , Ihle Christoph , Ateschrang Atesch , Maiotti Marco , Harrer Jörg , Dickschas Jörg 
Published: February 2019

AbstractThis article provides an overview of symptomatic torsional deformities of the lower extremity, and operative treatment techniques are described in detail. A definition of torsion versus rotation as well as information to physical examination and the relevance of radiological evaluation is given. Based on current literature and the own personal experience of the authors in osteotomies, surgical techniques at the proximal and at the distal femur, as well as at the tibia are presented.
Cemented versus Cementless Stems in Revision Total Knee Arthroplasty
Authors: Driesman Adam S. , Macaulay William , Schwarzkopf Ran 
Published: February 2019

AbstractSuccessful arthroplasty of the knee requires a stable foundation for implant placement, adequate mechanical alignment, and durable fixation. In the revision setting, the later may be difficult to obtain, especially in the setting of significant bone loss. While augments, cones, and sleeves have greatly enhanced the modern knee surgeon's ability to gain fixation in metaphyseal bone, stems continue to be a cornerstone tool in revision arthroplasty to bypass deficient or damaged bone surfaces to enhance structural stability of a revision construct. When placing a revision construct, there remains two options to assist with fixation, either fully cementing the entire implant or using a “hybrid” system, which combines an uncemented press-fit diaphyseal stem with cement in both the metaphysis and metaphysis–diaphysis junction of the keel. In this review, we discuss the history of these two techniques, evaluate the theoretical benefits and pitfalls, and assess the best evidence supporting each in the literature. To conclude, we will examine future directions and questions needed to better elucidate the best treatment options in a variety of revision scenarios.
AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer
Authors: Kubli Shawn P. , Bassi Christian , Roux Cecilia , Wakeham Andrew , Göbl Christoph , Zhou Wenjing , Jafari Soode Moghadas , Snow Bryan , Jones Lisa , Palomero Luis , Thu Kelsie L. , Cassetta Luca , Soong Daniel , Berger Thorsten , Ramachandran Parameswaran , Baniasadi Shakiba P. , Duncan Gordon , Lindzen Moshit , Yarden Yosef , Herranz Carmen , Lazaro Conxi , Chu Mandy F. , Haight Jillian , Tinto Paul , Silvester Jennifer , Cescon David W. , Petit Anna , Pettersson Sven , Pollard Jeffrey W. , Mak Tak W. , Pujana Miguel A. , Cappello Paola , Gorrini Chiara 
Published: February 2019

Significance
Basal-like/BRCA1-associated breast cancer (BC) is a very aggressive form of BC that frequently occurs in young women, with devastating effects. Since tailored therapies are lacking for this type of tumor, scientists and clinicians are searching for weaknesses that can be therapeutically exploited. Here we describe the role of the transcription factor aryl hydrocarbon receptor (AhR) in supporting BC growth by controlling reactive oxygen species (ROS) levels and the tumor-promoting features of the microenvironment. In BC cells, AhR activation mediates the link between intracellular ROS regulation and the protumorigenic functions of the surrounding immune system. We propose that tailored inhibition of AhR-regulated pathways can lead to BC eradication by pushing it beyond its ROS tolerance limit and depriving it of tumor-supporting immune cells.
Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
Authors: Jia Dongya , Lu Mingyang , Jung Kwang Hwa , Park Jun Hyoung , Yu Linglin , Onuchic José N. , Kaipparettu Benny Abraham , Levine Herbert 
Published: February 2019

Significance
Metabolic plasticity allows cancer cells to adjust their metabolic phenotypes to adapt in hostile environments. There is an urgent need to understand the cross-talk between gene regulation and metabolic pathways underlying cancer metabolic plasticity. We establish a theoretical framework to decode the coupling of gene regulation and metabolic pathways. Our work characterizes a hybrid metabolic state where cells can use both glycolysis and oxidative phosphorylation (OXPHOS) and a possible metabolically inactive state where cells have low activity of both glycolysis and OXPHOS. We show that targeting both OXPHOS and glycolysis may be necessary to eliminate cancer aggressiveness. Our work serves as a platform to target abnormal metabolism in cancer by modulating both genes and metabolic pathways.