bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soft tissue status and crestal bone loss around conventionally‐loaded dental implants placed in cigarette‐ and waterpipe (narghile) smokers: 8‐years' follow‐up results
Authors: Alahmari Fatemah , Javed Fawad , Ahmed Zain Uddin , Romanos Georgios E. , Al‐Kheraif Abdulaziz A. 
Published: March 2019

AbstractBackgroundWe hypothesized that crestal bone loss (CBL) and peri‐implant soft tissue inflammation are increased when conventionally‐loaded dental implants are placed in cigarette and waterpipe smokers compared to nonsmokers.PurposeThe present 8‐years' follow‐up retrospective clinical study evaluated the stability of the conventionally‐loaded dental implants placed in cigarette‐ and waterpipe (narghile) smoking and nonsmoking population group.Materials and MethodsSelf‐reported cigarette‐smokers, waterpipe users along with never‐smokers have been included. Data pertaining to gender, age, duration and frequency of cigarette‐smoking, and usage of waterpipe were collected using a preformed questionnaire. Probing depth (PD), bleeding on probing (BOP), and peri‐implant plaque index (PI) were recorded measuring mesial and distal CBL on digital bitewing radiographs. Study power estimated with group comparisons performed using the Kruskal‐Wallis and Bonferroni post‐hoc adjustment tests. Statistically significant P‐values of less than 0.05 were considered.ResultsForty‐one cigarette‐smokers, forty waterpipe‐users, and forty‐two never‐smokers with mean ages of 44.5 ± 4.3, 41.2 ± 4.7, 43.3 ± 2.8 years, respectively, were included. The mean duration of smoking habit and duration of each session of cigarette‐smoking was 5.5 ± 0.3 years and 7.7 ± 1.2 minutes, respectively. The mean period of waterpipe use and time of each session of was 10.6 ± 0.8 years and 20.2 ± 3.1 minutes, respectively. Among cigarette‐smokers, waterpipe‐users and never‐smokers, the implants had been in function for 8.5 ± 0.3, 8.6 ± 0.3, and 8.5 ± 0.5 years, respectively. PD, CBL, and peri‐implant PI were positively more among cigarette and waterpipe smoking users (P < 0.05) than with never‐smokers. Peri‐implant bleeding on probing was significant among never‐smokers (P < 0.05) compared to waterpipe‐users and cigarette‐smokers. There was no difference in Peri‐implant PI, PD, and CBL in cigarette‐smokers and waterpipe‐users.ConclusionsCigarette‐smokers and waterpipe users are vulnerable to peri‐implant soft tissue inflammation and CBL than never‐smokers. There is no variation in the severity of peri‐implant soft tissue inflammation and CBL in waterpipe and cigarette users.
Host‐size decisions of female parasitoid wasps seeking hidden hosts
Authors: Krimmel Billy A. , Morse Douglass H. 
Published: March 2019

1. Choice of host size may play a critical role in parasitoid success, a task that takes on added complications when dealing with concealed hosts, but most such studies of insect behaviour have only taken place in the laboratory.2. This study investigates the success of a wasp (Alabagrus texanus: Braconidae) in finding host caterpillarsHerpetogramma theseusalis(Crambidae) of the most effectively handled size hidden in shelters, in both the field and the laboratory.3. First, the study tested wasp preference and success in parasitizing large, middle‐sized and small caterpillars (> 5, 3–5, < 3 mm) presented in the open, one at a time, in the laboratory. The wasps attacked (inserted or attempted to insert their ovipositor) a higher proportion of middle‐sized (3–5 mm) caterpillars compared with either small (< 3 mm) or large (> 5 mm) caterpillars. Naïve wasps attacked large caterpillars more often than did experienced wasps. Wasps responded to increasing caterpillar size by increasing the number of legs used to pin their prey rather than by increasing handling time.4. The frequencies of visits to shelters in the field containing a majority of either large or middle‐sized caterpillars were then compared, followed by a test providing the wasps with similar choices under controlled laboratory conditions. Wasps most frequently visited shelters containing a majority of middle‐sized caterpillars both in the field and under controlled laboratory conditions.5. The combined results confirmed that the wasps can size‐select their hosts both in the field and in laboratory tests.
Local adaptation, dispersal evolution, and the spatial eco‐evolutionary dynamics of invasion
Authors: Andrade‐Restrepo Martín , Champagnat Nicolas , Ferrière Régis 
Published: March 2019

AbstractLocal adaptation and dispersal evolution are key evolutionary processes shaping the invasion dynamics of populations colonizing new environments. Yet their interaction is largely unresolved. Using a single‐species population model along a one‐dimensional environmental gradient, we show how local competition and dispersal jointly shape the eco‐evolutionary dynamics and speed of invasion. From a focal introduction site, the generic pattern predicted by our model features a temporal transition from wave‐like to pulsed invasion. Each regime is driven primarily by local adaptation, while the transition is caused by eco‐evolutionary feedbacks mediated by dispersal. The interaction range and cost of dispersal arise as key factors of the duration and speed of each phase. Our results demonstrate that spatial eco‐evolutionary feedbacks along environmental gradients can drive strong temporal variation in the rate and structure of population spread, and must be considered to better understand and forecast invasion rates and range dynamics.
Assessment of a vertical slot fishway in south‐eastern Australia designed to pass numerous species and size classes of fish
Authors: O'Connor Justin , Pickworth Andrew , Fanson Ben , Lovric Denis 
Published: March 2019

SummaryIn the Barwon River, Australia, a tidal barrage formed a major impediment to fish movement so in 2013 a vertical slot fishway was installed. The assessment of fishways on tidal barriers is rare in Australia so to ensure the fishway was achieving its ecological objective (i.e. successfully passing the target size range of fish of 20–400 mm total length), fish were trapped at the entrance and exit on 12 occasions and the species composition, abundance and length of fish at the two locations were compared. Additionally, a section of the river downstream of the fishway was sampled to ensure fishway trapping accurately reflected the species composition wanting to use the fishway to move upstream. Eighteen species and 69,246 individual fish were caught in the fishway traps. Catch rates between locations did not differ for Common Galaxias (Galaxias maculatus) or Australian Smelt (Retropinna semoni), although species‐specific catch rates were lower at the exit for Flat‐headed Gudgeon (Philypnodon grandiceps), Tupong (Pseudaphritis urvillii) and Yellow‐eye Mullet (Aldrichetta forsteri). Length distribution between locations only differed for Australian Smelt with small fish under‐represented at the exit location (<25 mm total length). Eight species of fish were collected downstream of the fishway that were not collected in it; however, all of these were estuarine dependent except the non‐native Common Carp (Cyprinus carpio). Our results indicate that vertical slot fishways are a suitable design for improving river connectivity at a low head, tidal barrages in south‐eastern Australia. The study reiterates the importance of reinstating connectivity for species with obligate marine/freshwater migratory life history traits, and the indirect benefits of increased productivity made available to upstream areas.
Dynamic analysis of proteomic alterations in response to N‐linked glycosylation inhibition in a drug‐resistant ovarian carcinoma cell line
Authors: Shu Jian , Dang Liuyi , Zhang Dandan , Shah Punit , Chen Lijun , Zhang Hui , Sun Shisheng 
Published: March 2019

Glycosylation inhibition can improve the efficacy of antitumor drugs and enhance the apoptosis of cancer cells, thus holding great potential for cancer treatment. Inhibition of N‐glycosylation induces endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), and eventually triggers ER stress‐related apoptosis. Unfortunately, the detailed timeline of these cell responses and protein expression alterations related to N‐glycosylation inhibition is not explicit yet, and the pathways involved in different stages of N‐glycosylation inhibition still need to be characterized. In this study, the dynamic proteome alterations related to N‐glycosylation inhibition were investigated by further analyzing our previously published quantitative proteomics data from tunicamycin (TM)‐treated ovarian carcinoma (OVCAR‐3) cells. The results revealed that N‐glycosylation inhibition not only directly affects the expression of glycosylated proteins but also alters an extended scale of proteins. Functional annotation of these altered proteins demonstrated that proteins related to ER stress start changing within 6 h, followed by UPR within 24 h, and eventually ER stress‐related apoptosis is triggered after 48 h, indicating the conversion of cellular response from positive to negative. The dynamic proteome data presented here provide important information for better understanding of the significance of N‐glycosylation to cell survival and TM‐related cancer treatment.
Region 1p13.2 including the RSBN1, PTPN22, AP4B1 and long non‐coding RNA genes does not bear risk factors for endemic pemphigus foliaceus (fogo selvagem)
Authors: Lobo‐Alves Sara Cristina , de Oliveira Liana Alves , Petzl‐Erler Maria Luiza 
Published: March 2019

AbstractPemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein‐1. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (fogo selvagem) is associated with polymorphisms at the cytogenetic location 1p13.2. Four single nucleotide polymorphisms that together tag 28 SNPs on a segment of approximately 312,000 bp encompassing the protein‐coding genes MAGI3, PHTF1, RSBN1, PTPN22, BCL2L15, AP4B1, DCLRE1B, the pseudogenes MTND5P20, RPS2P14 (AL133517.1) and the long non‐coding RNA genes AL137856.1, and AP4B1‐AS1 were used as markers for association analysis in a case–control study. Allele, genotype and haplotype frequencies of rs33996649, rs2476601, rs3789604 and rs3195954 were compared between patient and control samples. No significant association was found. Lack of association with rs2476601 of the PTPN22 gene agrees with previous results for pemphigus vulgaris and the Tunisian form of endemic pemphigus foliaceus. The other three SNPs had never been analysed before in any form of pemphigus. We conclude that variants in structural and regulatory sites of region 1p13.2 are not susceptibility factors for fogo selvagem. We suggest careful investigation of this genomic region in diseases that had been previously associated with PTPN22, since there are several other genes relevant for immune‐mediated diseases located in 1p13.2.
John Webster on Dogmatics and Ethics
Authors: O’Donovan Oliver 
Published: March 2019

AbstractFrom his earliest published writing Webster identified the moral life as the horizon of dogmatic enquiry, and his last‐published work offers a subtle clarification of how dogmatics relates to ethics. The principle ‘action follows being’ governs both the relation of the two sub‐disciplines and the internal logic of each. As theology is a knowledge acquired not only speculatively but also practically, dogmatics must look forward and practical theology look back. Their interaction covers the whole range of theological topics. It is a fittingly Chalcedonian conception stressing the duality of dogmatics and ethics alongside their unity. While specialized dogmatics and ethics are legitimate, the two remain proximate, in a definite order of origin and derivation. The temptation of a de‐moralized theology equalled by that of a theology wrongly constructed on a moral a priori. In his late essays Webster presents worked examples of how dogmatics may handle moral questions without venturing into casuistic exploration of dilemmas. One essay, however, goes further, troublingly describing ‘mortification and vivification’ as the primary human acts of the regenerate state, a function that the tradition has always assigned to love.
The Gift of the Non aliud: Creation from Nothing as a Metaphysics of Abundance
Authors: McFarland Ian A. 
Published: March 2019

AbstractAlthough the doctrine of creation from nothing may seem to instantiate a metaphysics of privation, in which the creature’s existence is ultimately one of humiliation, further reflection shows that this conclusion is not justified. For God to be over against the creature as an other who might threaten its autonomy in this way would imply a gap between God’s will and creaturely substance that is inconsistent with creation ex nihilo, according to which creatures are other than God, but God, as the exclusive ground of creaturely existence, is ‘Not other’ than they. This point disrupts the relationships of privation or dependence that mark inner‐worldly acts of creating. To be (always only partly) dependent on a created other is indeed to be revealed as less than sufficient unto oneself; but to be (wholly) dependent on the ‘Not other’ is to be fully sufficient to fulfil the promise of one’s existence.
The Ontology of Scripture and the Ethics of Interpretation in the Theology of John Webster
Authors: Sarisky Darren 
Published: March 2019

AbstractThis article outlines the ontology of Scripture and the ethics of interpretation in the theology of John Webster, covering how the doctrines of revelation, sanctification, inspiration and canonization condition the locus of interpretation. Particular focus is given to the way in which the triune God’s presence and perfection determine Webster’s explication of these topics. The article’s conclusion is that Webster’s work makes a major contribution with the basic approach that it takes, thinking about the Bible in relation to a wider field, though it does not entirely overcome the obstacle of the dualism between history and transcendence.
A multicolor persistent luminescent phosphor Sr2Ga2GeO7:Pr3+ for dynamic anticounterfeiting
Authors: Ji Liping , Zhou Jinyu , Zhang Jiachi , Zhang Zhiya , Ma Zhidong , Wang Wenxiang , Li Huihui , Wu Chunfang 
Published: March 2019

AbstractPersistent luminescence (PersL) phosphor is a glow‐in‐the‐dark material that has been widely applied. Here, we report a multicolor PersL phosphor Sr2Ga2GeO7:Pr3+. The PersL color can be tuned from deep red to blue. It reveals that the luminescent color modulation of the Sr2Ga2GeO7:Pr3+ phosphor is essentially associated with the cross‐relaxation effect of Pr3+ in the host with low‐phonon assistance energy. The PersL lifetime of the multicolor phosphors can be also tuned. Based on the unique features of Sr2Ga2GeO7:Pr3+ phosphor, some simple PersL images are fabricated to emit dynamic multicolor information, and it shows that the PersL image even depicts dynamic multicolor anticounterfeiting.
Distribution of atopic dermatitis lesions in United States adults
Authors: Silverberg J.I. , Margolis D.J. , Boguniewicz M. , Fonacier L. , Grayson M.H. , Ong P.Y. , Chiesa Fuxench Z.C. , Simpson E.L. , Gelfand J.M. 
Published: March 2019

AbstractBackgroundThe distribution of atopic dermatitis (AD) lesions and its impact on quality of life (QOL) is not well established in the US adult population.ObjectiveTo elucidate the distribution of AD lesions and its impact on QOL in US adults with AD.MethodsA cross‐sectional, population‐based study of 602 adults was performed. AD was determined using modified UK Diagnostic Criteria, and its lesional distribution was assessed. QOL was assessed using Dermatology Life Quality Index (DLQI). Latent class analysis (LCA) was used to determine distinct phenotypes of AD lesional distribution. Multivariable logistic regression was used to determine the relationship between DLQI and distinct phenotypes.ResultsThe most common sites of skin lesions were reported to be the popliteal fossae, lower legs, dorsal feet and antecubital fossae. Most persons reported partial (19.0%) or complete (63.0%) symmetry of lesions on the extremities. Lesions on the trunk were significantly more common in blacks and Hispanics. Age ≥ 60 years was associated with significantly lower proportions of active lesions on the face and scalp, and significantly higher proportion of lesions on the buttocks or genitals. LCA identified 5 classes of lesional distribution: 1. lower probabilities of lesions affecting any sites; 2. Higher probability of lesions involving the anterior and posterior neck and trunk; 3. lesions involving the antecubital fossae and upper extremities; 4. lesions involving the arms, posterior hands, genitals and buttocks, and to a lesser extent face, palms and legs; 5. lesions affecting all sites. Class‐2 (multivariable logistic regression; adjusted odds ratio [95% confidence interval]: 7.19 [3.21–16.07], class‐3 (7.11 [3.20–15.80]), class‐4 (6.90 [3.07–15.50]) and class‐5 (7.92 [3.54–17.71]) were all significantly associated with higher DLQI scores compared to class 1.ConclusionAD is associated with heterogeneous distribution of AD lesions, and distinct phenotypes that are associated with QOL impact.
Evaluation of anal carcinoma screening in male and female HIV patients at an interdisciplinary HIV therapy centre
Authors: Todorova A. , Schwierzeck V. , Turek D. , Zink A. , Schwerdtfeger C. , Kaliebe K. , Spinner C.D. , Traidl‐Hoffmann C. 
Published: March 2019

AbstractBackgroundIncidence of anal carcinoma is increased in people living with HIV (PLWH). Due to the improved life expectancy in PLWH, identifying appropriate prevention strategies for non‐AIDS‐defining cancer types such as anal carcinoma has become a priority in managing PLWH today.ObjectiveWe aimed to evaluate anal cytology assessment as screening tool for anal dysplasia and/or carcinoma in PLWH, regardless of gender or sexual orientation. Additionally, we investigated the correlation between cancer risk factors and abnormal screening results in our patient cohort.MethodsPeople living with HIV from the Interdisciplinary HIV Centre of the University Hospital rechts der Isar in Munich, Germany (IZAR), were screened for anal carcinoma by single cytobrush examination and anal Papanicolaou (PAP) smear assessment from 2013 to 2015. Patients with abnormal PAP smear result were offered a follow‐up examination after 12 months. Differences between two groups were tested for statistical significance using Student's t‐test and Mann–Whitney U‐test, as appropriate.ResultsIn total, 101 PLWH were included. 26.7% of subjects (n = 27) were PAP IIID, and 9.9% (n = 10) were PAP IVa. Seven female subjects had an abnormal finding at screening. Smoking was significantly associated with abnormal findings at screening (P = 0.005). In addition, our study found an association between sexually transmitted infections (STI) and anal dysplasia. Condylomata acuminata were increased in subjects with PAP IIID/PAP IVa (P = 0.045). Reactive syphilis serology was found to be significantly associated with abnormal screening results (P = 0.016), respectively.ConclusionOur results demonstrate that smoking and two common STIs, condylomata acuminata and syphilis, are risk factors associated with advanced anal intraepithelial neoplasia (AIN) stages in our PLWH cohort. While further analysis is needed to determine diagnostic guidelines concerning AIN in PLWH, these results suggest that interdisciplinary lifestyle prevention strategies are required to reduce the risk factors for AIN in PLWH in an outpatient setting.
Biological treatments for paediatric psoriasis : a retrospective observational study on biological drug survival in daily practice in childhood psoriasis
Authors: Phan C. , Beauchet A. , Burztejn A.‐C. , Severino‐Freire M. , Barbarot S. , Girard C. , Lasek A. , Reguiai Z. , Hadj‐Rabia S. , Abasq C. , Brenaut E. , Droitcourt C. , Perrussel M. , Mallet S. , Phan A. , Lacour J.‐P. , Khemis A. , Bourrat E. , Chaby G. , Deborde R. , Plantin P. , Maruani A. , Piram M. , Maccari F. , Fougerousse A.‐C. , Kupfer‐Bessaguet I. , Balguérie X. , Barthelemy H. , Martin L. , Quiles‐Tsimaratos N. , Mery‐Brossard L. , Pallure V. , Lons‐Danic D. , Bouilly‐Auvray D. , Beylot‐Barry M. , Puzenat E. , Aubin F. , Mahé E. ,   For The Groupe de Recherche de la Société Française de Dermatologie Pédiatrique,   The Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie
Published: March 2019

AbstractBackgroundThree biotherapies – etanercept, adalimumab and ustekinumab – are licensed in childhood psoriasis. The few data available on their efficacy and tolerance are mainly derived from industry trials. However, biological drug survival impacts long‐term performance in real‐life settings.ObjectiveThe objective of this study was to evaluate the survival rates of biological therapies in children with psoriasis in real‐life conditions. Secondary objectives were to evaluate the factors associated with the choice of the biological therapy and to report severe adverse events.Materials and methodsThis study was an observational retrospective study. Data were extracted from the clinical records of 134 children. Kaplan–Meier estimates were used to analyse drug survival overall and in subgroups of plaque psoriasis, bio‐naïve and non‐naïve patients.ResultsWe analysed 184 treatment courses: 70 with etanercept, 68 with adalimumab and 46 with ustekinumab. Factors associated with the choice of first‐line biological agent were age at initiation (younger for adalimumab, P < 0.0001), age at onset of psoriasis (younger for adalimumab and etanercept, P = 0.03) and baseline Psoriasis Assessment Severity Index and Physician global assessment (both higher for adalimumab, P < 0.001). Drug survival rates were higher for ustekinumab than for adalimumab and etanercept (P < 0.0001) for all treatment and all psoriasis types, plaque‐type psoriasis (P = 0.0003), patients naïve for biological agents (P = 0.0007) and non‐naïve patients (P = 0.007). We reported eight serious adverse events (SAEs): severe infections (n = 3), significant weight gain (n = 2), psoriasis flare (n = 1) and malaise (n = 1). Biological therapy was discontinued in three children (one with psoriasis flare and two with weight gain). Only the two cases of weight gain resulted in an unfavourable outcome.ConclusionsOur real‐life comparative study found that ustekinumab had the best drug survival outcome. The profile of SAEs in children was comparable to that in adults. These results will assist dermatologists in the decision‐making process when choosing treatment options for children with psoriasis in daily practice.
Getting at Mode Share: Comparing 3 Methods of Travel Mode Measurement for School Travel Research
Authors: Sersli Stephanie , Rothman Linda , Winters Meghan 
Published: March 2019

ABSTRACTBACKGROUNDMode share is an important metric for active school travel programs. Common methods for measuring mode share include Hands Up surveys and family surveys, but these require teacher and parental involvement. We used these methods as part of an evaluation of a school‐based bicycle training program, and added a novel observational count approach. This paper compares mode share results across the 3 methods.METHODSWe collected data over 2015–2017 at 16 elementary schools. Our outcome of interest was mode share (walk, drive, and bicycle).RESULTSWe found variations in travel mode estimates between methods and across schools. Overall most school journeys were made by walking (55.7% by observational counts, 46.3% by Hands Up surveys, and 51.5% by family surveys) or car (42.5%, 51.4%, and 46.2%, respectively), and a small proportion by bicycle (1.8%, 2.3%, and 2.2%, respectively). At individual schools, Hands Up and family survey results were similar; there was less agreement between these and observational counts.CONCLUSIONSchool travel practitioners face pragmatic choices in data collection. Observational counts are a nonintrusive method suited for school‐wide travel patterns. Hands up and family surveys may be more appropriate for assessing differences between classrooms, ages, or family characteristics.