bluuebunny/crossref_metadata_2025_split huggingface dataset:
Next of kin’s quality of life before and after implementation of a knowledge-based palliative care intervention in nursing homes
Authors: Bökberg Christina , Behm Lina , Ahlström Gerd 
Published: August 2019

Abstract
Purpose
The purpose of this study was to evaluate whether an educational palliative care intervention improved the quality of life for next of kin to older persons in nursing homes.

Methods
Altogether, 90 next of kin in the intervention group and 105 next of kin in the control group were included. Data were collected using the WHOQOL-BREF questionnaire, answered before and 3 months after the intervention was completed. Descriptive and comparative analyses were performed.

Results
This study found a statistically significant increase in the Physical health subscale in the intervention group but not in the control group. In contrast, the General health score decreased in the control group but not in the implementation group. Furthermore, we found an increase in the item able to perform activities of daily living in the intervention group and a decrease in the item energy and fatigue in the control group.

Conclusion
The results indicated small statistical changes regarding next of kins’ QoL in favour of the intervention. Lessons learned from the study for future research are to include next of kin as participants at meetings about next of kin and to include more meetings about the theme next of kin. Both approaches would bring a stronger focus on the family-centred care aspect of the intervention into the education component, which this study indicates the need for.

Trial registry
Trial registration NCT02708498. Date of registration 26 February 2016.
Entrepreneurship, culture, and the epigenetic revolution: a research note
Authors: Acs Zoltan , Lappi Emma 
Published: August 2019

AbstractWe show how the type of alcohol consumed is related to the type of entrepreneurship present for economies in Europe. We differentiate between beer-, wine-, and spirit-drinking countries and distinguish between productive, unproductive, and destructive entrepreneurship. The underlying links do not emerge from drinking per se but rather the drinking habits and taste for beverage types capture deep cultural features and cultural similarities amongst the countries. Societies that prefer to drink beer are closer to each other culturally than those which prefer drinking wine or spirits. Therefore, the taste for alcohol type is merely an instrument in explaining cultural and institutional differences across entrepreneurship. Broadly speaking, beer-drinking countries are characterized by higher shares of productive entrepreneurship, wine-drinking countries with unproductive entrepreneurship, and spirit-drinking countries with destructive entrepreneurship. We discuss mechanisms in which the results are found and highlight a new research agenda, emphasizing the potential role of epigenetics.
AI vs AI: fraudsters turn defensive technology into an attack tool
Authors: Vaithianathasamy Swami 
Published: August 2019

The first rule of managing online fraud and mitigating risk is to remember that fraudsters are entrepreneurs. While it's tempting to think of those committing digital fraud as hoody-wearing lone wolves spending hours in their bedroom working to weasel their way into someone's online account, in reality professional fraud operations look more like the JP Morgan trading floor. Cyber criminals are not simple, hoodie-wearing lone wolves. Many are sophisticated fraud operations using the most advanced technology, including artificial intelligence (AI). The energy and ingenuity with which fraud rings and cyber criminals have deployed AI-based solutions has matched that of the businesses and organisations that work to protect themselves from bad actors. Machines have been put to malicious use in ways ranging from click farms to complex model extraction schemes, explains Swami Vaithianathasamy of Signifyd.
Fermentation quality and aerobic stability of low moisture-crimped wheat grains manipulated by organic acid-based additives
Authors: Franco M. , Stefanski T. , Jalava T. , Kuoppala K. , Huuskonen A. , Rinne M. 
Published: August 2019

AbstractPreservation of moist grain anaerobically by so-called crimping has many advantages. Generally, preservation has been successfully performed when grain is harvested at 30–40% moisture content (MC). However, there is a trend towards using drier than the optimal MC of the raw material. This leads to an increasing need to control aerobic spoilage of the material and also to experimental challenges in assessing the quality and stability of low-MC crimped grain. The objective of the current work was to evaluate fermentation quality, microbial composition and aerobic stability (AS) of drier than the optimal crimped grain ensiled with different additives and to use these materials to compare three different AS evaluation methods. Crimped wheat grain with 28% MC was ensiled using eight additive treatments based mainly on formic and propionic acids including a control without any additive. The low MC resulted in no lactic acid fermentation, but significant ethanol formation occurred in the control. The treatments used resulted in clear differences in microbial quality and AS of the feeds, and use of formic and propionic acid-based additives provided a clear benefit in improving the AS of crimped wheat grain. The correlation between increasing temperature and carbon dioxide (CO2) production under aerobic conditions was very close, indicating that CO2produced by aerobic bacteria can be used as a method of evaluating AS. Visual inspection of mould growth resulted in somewhat different ranking of the treatments.
Gain and loss of subcutaneous and abdominal fat depot mass from late pregnancy to 100 days in milk in German Holsteins
Authors: Ruda Lena , Raschka Claudia , Huber Korinna , Tienken Reka , Meyer Ulrich , Dänicke Sven , Rehage Jürgen 
Published: August 2019

AbstractThis research paper addresses the hypothesis that in times of negative energy balance around parturition in dairy cattle, lipids stored in adipocytes are mobilised in a more intensive manner out of the abdominal depots than out of the subcutaneous adipose tissues. Furthermore, the impact of niacin supplementation and energy density of the ration on adipose tissue mass gain and loss was assessed. Absolute masses of subcutaneous (SCAT), retroperitoneal (RPAT), omental (OMAT), mesenterial (MAT) and abdominal adipose tissue as a whole (AAT) were estimated by ultrasonography at −42, 3, 21 and 100 DIM. Absolute and relative daily gain during dry period (−42 to 3 DIM) and loss in fresh cow period (3 to 21 DIM) and early lactation period (22 to 100 DIM) were calculated. Feeding regime neither by niacin nor by energy density exerted any effect on adipose tissue masses. The AAT was always bigger than SCAT, but RPAT, OMAT and MAT did not differ amongst each other. All depot masses showed similar patterns with an increase during dry period and a decrease after calving. In fresh cow period AAT absolutely and relatively lost more mass than SCAT. This confirms that AAT is more intensively mobilised than SCAT during that time span. Further absolute daily gain during dry period was strongly negatively correlated with absolute daily loss during fresh cow period. This underlines the impact of individual body condition on adipose mobilisation in periparturient dairy cows. According to these results, it has to be taken into account that the largest amount of fat mobilised in the fresh cow period origins from AAT. This might impact the pattern of adipose derived metabolites and metabolic effectors interacting in physiological and deregulated adaptation to negative energy balance.
On the bivariate Erdős–Kac theorem and correlations of the Möbius function
Authors: MANGEREL ALEXANDER P. 
Published: August 2019

AbstractGiven a positive integer n let ω (n) denote the number of distinct prime factors of n, and let a be fixed positive integer. Extending work of Kubilius, we develop a bivariate probabilistic model to study the joint distribution of the deterministic vectors (ω(n), ω(n + a)), with n ≤ x as x → ∞, where n and n + a belong to a subset of ℕ with suitable properties. We thus establish a quantitative version of a bivariate analogue of the Erdős–Kac theorem on proper subsets of ℕ.We give three applications of this result. First, if y = x0(1) is not too small then we prove (in a quantitative way) that the y-truncated Möbius function μy has small binary autocorrelations. This gives a new proof of a result due to Daboussi and Sarkőzy. Second, if μ(n; u) :=e(uω(n)), where u ∈ ℝ then we show that μ(.; u) also has small binary autocorrelations whenever u = o(1) and $u\sqrt {\mathop {\log }\nolimits_2 x} \to \infty$, as x → ∞. These can be viewed as partial results in the direction of a conjecture of Chowla on binary correlations of the Möbius function.Our final application is related to a problem of Erdős and Mirsky on the number of consecutive integers less than x with the same number of divisors. If $y = x^{{1 \over \beta }}$, where β = β(x) satisfies certain mild growth conditions, we prove a lower bound for the number of consecutive integers n ≤ x that have the same number of y-smooth divisors. Our bound matches the order of magnitude of the one conjectured for the original Erdős-Mirsky problem.
Impact of the Community Eligibility Provision on meal counts and participation in Pennsylvania and Maryland National School Lunch Programs
Authors: Pokorney Paige E , Chandran Avinash , Long Michael W 
Published: August 2019

AbstractObjective:To determine whether school-level participation in the federal Community Eligibility Provision (CEP), which provides free school lunch to all students, is associated with school meal participation rates. Participation in school meals is important for decreasing food insecurity and improving child health and well-being.Design:Quasi-experimental evaluation using negative binomial regression to predict meal count rates per student-year overall and by reimbursement level adjusted for proportion eligible for free and reduced-price lunch (FR eligibility) and operating days.Setting:Schools (grades kindergarten to 12th) participating in the National School Lunch Program (NSLP) in Maryland and Pennsylvania, USA, from the 2013–2015 (n 1762) and 2016–2017 (n 2379) school years.Participants:Administrative, school-level data on school lunch counts and student enrolment.Results:CEP was associated with a non-significant 6 % higher total NSLP meal count adjusting for FR eligibility, enrolment and operating days (rate ratio = 1·06, 95 % CI 0·98, 1·14). After controlling for participation rates in the year prior to CEP implementation, the programme was associated with a significant 8 % increase in meal counts (rate ratio = 1·08, 95 % CI 1·03, 1·12). In both analyses, CEP was associated with lower FR meal participation and substantial increases in paid meal participation.Conclusions:School-level implementation of CEP is associated with increases in total school meal participation. Current funding structures may prevent broader adoption of the programme by schools with fewer students eligible for FR meals.
No auxinic herbicide–resistance cost in wild radish (Raphanus raphanistrum)
Authors: Goggin Danica E. , Beckie Hugh J. , Sayer Chad , Powles Stephen B. 
Published: August 2019

AbstractWild radish (Raphanus raphanistrum L.) is a problematic and economically damaging dicotyledonous weed infesting crops in many regions of the world. Resistance to the auxinic herbicides 2,4-D and dicamba is widespread in Western Australian R. raphanistrum populations, with the resistance mechanism appearing to involve alterations in the physiological response to synthetic auxins and in plant defense. This study aimed to determine whether these alterations cause inhibition in plant growth or reproduction that could potentially be exploited to manage 2,4-D–resistant populations in cropping areas. Therefore, the morphology and seed production of resistant and susceptible populations were compared in an outdoor pot study, with plants grown in the presence and absence of competition by wheat (Triticum aestivum L.). The susceptible and resistant R. raphanistrum populations were equally suppressed by wheat competition, with plant growth and seed production being decreased by approximately 50%. Although resistant populations produced less vegetative biomass than susceptible populations, there was no negative association between resistance and seed production. Therefore, it is unlikely that any nonherbicidal management practices will be more efficacious on 2,4-D–resistant than 2,4-D–susceptible R. raphanistrum populations.
Partitioning Dynamics of Gravity‐Driven Unsaturated Flow Through Simple T‐Shaped Fracture Intersections
Authors: Yang Zhibing , Xue Song , Zheng Xiaokang , Chen Yi‐Feng 
Published: August 2019

AbstractA fundamental understanding of the fluid movement and dynamic partitioning process at fracture intersections is important to accurately predict water infiltration and contaminant transport in networks of fractures. We present an experimental study on the flow‐splitting behavior at a T‐shaped intersection. Different combinations of apertures of the vertical (bv) and horizontal (bh) fractures are considered. Experimental results confirm that the gravity‐driven flow in the vertical fracture transitions from droplet to rivulet mode as the flow rate increases. We quantify the flow dynamics through the intersection and especially focus on the partitioning efficiency (η) defined as the percentage of flow partitioned into the horizontal fracture. We identify three regimes of flow partitioning at the intersection for the case of bv < bh: total partitioning (η → 1), splitting or partial bypass (0 < η < 1), and total bypass (η → 0). The total bypass regime is associated with the rivulet mode with a flow rate higher than ~1.5 ml/min. We find a simple relationship between η and the flow rate Q for droplet flow, η = min(1, ChQ−1), where Ch is a threshold flow rate below which droplets almost completely imbibe into the horizontal fracture, leading to η → 1. A force balance analysis links Ch to a critical droplet length for the transition from complete partitioning to path splitting. The obtained relationship is further supported by numerical simulations of droplet flow through intersections. The results and analysis from this study may provide insights and physical constraints on construction of reduced order unsaturated flow models based on simplified discrete fracture networks.
The Missing Solar Cycle Response of the Polar Summer Mesosphere
Authors: Hervig Mark E. , Siskind David E. , Bailey Scott M. , Merkel Aimee W. , DeLand Matthew T. , Russell James M. 
Published: August 2019

AbstractThe response of the polar mesosphere to the 11‐year solar cycle is investigated using satellite observations from 1979 to 2018. Solar maximum is expected to cause higher temperatures and lower water vapor in the upper mesosphere, thus reducing the amount of ice in polar mesospheric clouds (PMCs). While PMCs showed a clear anticorrelation with the solar cycle before roughly 2002, this response is absent during recent years. PMCs are controlled by temperature and water vapor, which were examined using mesospheric observations during 1992–2018. The main cause of the diminished solar cycle in PMCs near 68°S and 68°N appears to be a dramatic suppression of the solar cycle response of water vapor. The solar cycle response of temperature also decreases after 2002, but calculations show that the decreased H2O response had more than 3 times the impact on PMCs than the reduction in temperature response.
The 2018 Martian Global Dust Storm Over the South Polar Region Studied With MEx/VMC
Authors: Hernández‐Bernal J. , Sánchez‐Lavega A. , del Río‐Gaztelurrutia T. , Hueso R. , Cardesín‐Moinelo A. , Ravanis E. M. , de Burgos‐Sierra A. , Titov D. , Wood S. 
Published: August 2019

AbstractWe study the 2018 Martian global dust storm (GDS 2018) over the Southern Polar Region using images obtained by the Visual Monitoring Camera (VMC) on board Mars Express (MEx) during June and July 2018. Dust penetrated into the polar cap region but never covered the cap completely, and its spatial distribution was nonhomogeneous and rapidly changing. However, we detected long but narrow aerosol curved arcs with a length of ~2,000–3,000 km traversing part of the cap and crossing the terminator into the nightside. Tracking discrete dust clouds allowed measurements of their motions that were toward the terminator with velocities up to 100 m/s. The images of the dust projected into the Martian limb show maximum altitudes of ~70 km but with large spatial and temporal variations. We discuss these results in the context of the predictions of a numerical model for dust storm scenario.
Thermoluminescence and Optically Stimulated Luminescence Measured in Marine Sediments Indicate Precipitation Changes Over Northeastern Brazil
Authors: R. Mendes Vinícius , Sawakuchi André O. , M. Chiessi Cristiano , F. Giannini Paulo C. , Rehfeld Kira , Mulitza Stefan 
Published: August 2019

AbstractMarine sediment cores offer a great number of proxies for reconstructions of past environmental conditions, such as ocean temperature, salinity, primary productivity, stratification of the upper water column, and continental precipitation. Up to date, continental precipitation archived in marine sediment cores is reconstructed based mainly on the hydrogen isotopic composition of plant‐wax compounds (i.e., n‐alkane δD) or on the ratio between terrigenous and marine sediments expressed as elemental ratios (e.g., ln (Fe/Ca)). Although these proxies provide reliable precipitation reconstructions, there are some inherent limitations, as plant‐wax δD application depends on the availability of n‐alkanes in marine sediments and elemental ratios can be influenced by other factors like the relative sea‐level, primary productivity, and postdepositional processes. Here we introduce new precipitation proxies based on optically stimulated luminescence and thermoluminescence signals of quartz and feldspar. The rationale is that when precipitation changes over the catchment through time, different sediment sources regarding weathering intensity and parent rock types are drained, supplying sediments with varying signals of luminescence to the ocean. We compared our new proxy records with records of well‐established proxies, for the same (ln (Fe/Ca)) and neighboring (n‐alkane δD) marine sediment cores. The comparison among all proxies as well as with a state‐of‐art transient climate model run (TraCE‐21ka) demonstrates that the new proxies accurately constrain precipitation changes over northeastern Brazil for the last 30,000 years. The main advantage of these new proxies relies on their fast response to precipitation changes over the continent. Furthermore, they are straightforward to measure and not expensive.
Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward
Authors: Jiang Changyou , Wang Xueying , Le Qiumin , Liu Peipei , Liu Cao , Wang Zhilin , He Guanhong , Zheng Ping , Wang Feifei , Ma Lan 
Published: August 2019

AbstractOpioids, such as morphine, are clinic analgesics which induce euphoria. Morphine exposure modifies the excitability and functional interactions between neurons, while the underlying cellular and molecular mechanisms, especially how morphine assembles heterogeneous interneurons (INs) in prelimbic cortex (PrL) to mediate disinhibition and reward, are not clear. Using approaches of optogenetics, electrophysiology, and cell type-specific RNA-seq, we show that morphine attenuates the inhibitory synaptic transmission from parvalbumin+ (PV)-INs onto pyramidal neurons in PrL via μ-opioid receptor (MOR) in PV-INs. Meanwhile, morphine enhances the inhibitory inputs from somatostatin+ (SST)-INs onto PV-INs, and thus disinhibits pyramidal neurons via δ-opioid receptor (DOR)-dependent Rac1 upregulation in SST-INs. We show that MOR in PV-INs is required for morphine-induced behavioral sensitization, while DOR as well as Rac1 activity in SST-INs is required for morphine-induced conditioned place preference and hyper-locomotion. These results reveal that SST- and PV-INs, functioning in PrL as a disinhibitory architecture, are coordinated by morphine via different opioid receptors to disinhibit pyramidal neurons and enhance reward.
Coherent anti-Stokes Raman spectroscopy of single and multi-layer graphene
Authors: Virga A. , Ferrante C. , Batignani G. , De Fazio D. , Nunn A. D. G. , Ferrari A. C. , Cerullo G. , Scopigno T. 
Published: August 2019

AbstractSpontaneous Raman spectroscopy is a powerful characterization tool for graphene research. Its extension to the coherent regime, despite the large nonlinear third-order susceptibility of graphene, has so far proven challenging. Due to its gapless nature, several interfering electronic and phononic transitions concur to generate its optical response, preventing to retrieve spectral profiles analogous to those of spontaneous Raman. Here we report stimulated Raman spectroscopy of the G-phonon in single and multi-layer graphene, through coherent anti-Stokes Raman Scattering. The nonlinear signal is dominated by a vibrationally non-resonant background, obscuring the Raman lineshape. We demonstrate that the vibrationally resonant coherent anti-Stokes Raman Scattering peak can be measured by reducing the temporal overlap of the laser excitation pulses, suppressing the vibrationally non-resonant background. We model the spectra, taking into account the electronically resonant nature of both. We show how coherent anti-Stokes Raman Scattering can be used for graphene imaging with vibrational sensitivity.
A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing
Authors: Petti Allegra A. , Williams Stephen R. , Miller Christopher A. , Fiddes Ian T. , Srivatsan Sridhar N. , Chen David Y. , Fronick Catrina C. , Fulton Robert S. , Church Deanna M. , Ley Timothy J. 
Published: August 2019

AbstractVirtually all tumors are genetically heterogeneous, containing mutationally-defined subclonal cell populations that often have distinct phenotypes. Single-cell RNA-sequencing has revealed that a variety of tumors are also transcriptionally heterogeneous, but the relationship between expression heterogeneity and subclonal architecture is unclear. Here, we address this question in the context of Acute Myeloid Leukemia (AML) by integrating whole genome sequencing with single-cell RNA-sequencing (using the 10x Genomics Chromium Single Cell 5’ Gene Expression workflow). Applying this approach to five cryopreserved AML samples, we identify hundreds to thousands of cells containing tumor-specific mutations in each case, and use the results to distinguish AML cells (including normal-karyotype AML cells) from normal cells, identify expression signatures associated with subclonal mutations, and find cell surface markers that could be used to purify subclones for further study. This integrative approach for connecting genotype to phenotype is broadly applicable to any sample that is phenotypically and genetically heterogeneous.