Potensi Interaksi Obat Antituberkulosis dan Anti Diabetes terhadap Efek Samping Obat pada Pasien Tuberkulosis-Diabetes Melitus di RSUD Al-Ihsan Bandung
Authors: Halima Rahma Ratu , Rahimah Santun Bhekti , Saefulloh Asep , Andriane Yuke , Suherian Endang 
Published: July 2019

Pengobatan tuberkulosis (TB) dengan diabetes melitus (DM) pada pasien TB-DM membutuhkan waktu yang cukup lama dan beragam sehingga memiliki risiko tinggi menyebabkan potensi interaksi obat dan menimbulkan efek samping obat. Penelitian ini bertujuan mengetahui hubungan potensi interaksi obat antituberkulosis dengan obat antidiabetes pada pasien TB dengan DM di Poli DOTS RSUD Al-Ihsan pada periode April–Mei 2018. Penelitian ini dilakukan dengan metode analitik observasional menggunakan pendekatan cross-sectional, pengambilan data obat yang terdapat pada rekam medik dan kuesioner yang telah dilakukan uji validitas dan uji reliabilitas. Data potensi interaksi obat diolah dengan memasukkan data obat yang dikonsumsi pasien menggunakan software pada Lexi-Interact. Subjek berjumlah 30 responden dipilih secara total sampling. Hasil penelitian menunjukkan frekuensi tertinggi potensi interaksi obat antituberkulosis-obat antidiabetes pada derajat berat sejumlah 12 dari 30 pasien. Efek samping yang terjadi pada pasien dengan frekuensi tertinggi adalah derajat ringan sejumlah 10 dari 30 pasien. Analisis dengan uji chi-square tidak memiliki nilai kemaknaan antara potensi interaksi obat dan efek samping obat (p=0,146). Simpulan, tidak terdapat hubungan potensi interaksi obat dengan efek samping yang timbul pada pasien TB dengan DM di Poli DOTS RSUD Al-Ihsan periode April–Mei 2018. POTENTIAL INTERACTIONS BETWEEN ANTI TUBERCULOSIS DRUG AND ANTI DIABETES DRUG WITH SIDE EFFECTS ON TUBERCULOSIS-DIABETES MELLITUS PATIENTS IN RSUD AL-IHSAN BANDUNGThe medication of tuberculosis (TB) with diabetes mellitus (DM) on TB-DM patients requires quiet a long and diverse time, so it has a high risk to potentially causing a medicine interaction and produce side effects. The research aimed to know the relation of potential interactions between anti tuberculosis medicine and anti diabetes drug with side effects on TB-DM patients in Directly Observed Treatment Short-course (DOTS) outpatient clinic of RSUD Al-Ihsan Bandung in April–May 2018. This research was done by cross sectional approach method by taking the drug data in the medical records and questionnaires which have been tested for validity and reliability. Data of potential drug interactions is processed by entering data of drug consumed by patient using software on Lexi-Interact. The subjects were 30 respondents, selected by total sampling. The results showed the highest frequency of potential anti-tuberculosis drug anti-diabetic drug interactions on severe degree 12 of 30 patients. The results also showed that the side effects occurring in patients with highest frequency were mild degrees of 10 of 30 patients. The analysis obtained by chi square test between potential drug interaction with side effect of drug is not having any meaning value with (p=0.146). In conclusion, there is no relation between potential drug interaction and side effect on TB-DM patients in Directly Observed Treatment Short-course (DOTS) outpatient clinic of RSUD Al-Ihsan Bandung in April–May 2018.