bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in KRAS-Mutant Cancers
Authors: Stewart Adam , Coker Elizabeth A. , Pölsterl Sebastian , Georgiou Alexandros , Minchom Anna R. , Carreira Suzanne , Cunningham David , O'Brien Mary ER. , Raynaud Florence I. , de Bono Johann S. , Al-Lazikani Bissan , Banerji Udai 
Published: July 2019

Abstract
It is increasingly appreciated that drug response to different cancers driven by the same oncogene is different and may relate to differences in rewiring of signal transduction. We aimed to study differences in dynamic signaling changes within mutant KRAS (KRASMT), non–small cell lung cancer (NSCLC), colorectal cancer, and pancreatic ductal adenocarcinoma (PDAC) cells. We used an antibody-based phosphoproteomic platform to study changes in 50 phosphoproteins caused by seven targeted anticancer drugs in a panel of 30 KRASMT cell lines and cancer cells isolated from 10 patients with KRASMT cancers. We report for the first time significant differences in dynamic signaling between colorectal cancer and NSCLC cell lines exposed to clinically relevant equimolar concentrations of the pan-PI3K inhibitor pictilisib including a lack of reduction of p-AKTser473 in colorectal cancer cell lines (P = 0.037) and lack of compensatory increase in p-MEK in NSCLC cell lines (P = 0.036). Differences in rewiring of signal transduction between tumor types driven by KRASMT cancers exist and influence response to combination therapy using targeted agents.
Atrial Fibrillation Catheter Ablation Improves 1-Year Follow-Up Cognitive Function, Especially in Patients With Impaired Cognitive Function
Authors: Jin Moo-Nyun , Kim Tae-Hoon , Kang Ki-Woon , Yu Hee Tae , Uhm Jae-Sun , Joung Boyoung , Lee Moon-Hyoung , Kim Eosu , Pak Hui-Nam 
Published: July 2019

Background:
Although atrial fibrillation (AF) has a risk of cognitive dysfunction, it is not clear whether AF catheter ablation improves or worsens cognitive function. This prospective case-control study sought to assess the 1-year serial changes in the cognitive function with or without AF catheter ablation.

Methods:
We evaluated the Montreal Cognitive Assessment score in 308 patients (71.4% male, 60.6±9.1 years of age, 34.1% persistent AF) who underwent AF ablation (ablation group) and 50 AF patients on medical therapy who met the same indication for AF ablation (control group), at baseline and 3 and 12 months after enrollment. Cognitive impairment was defined as a published cutoff score of <23 points. To exclude any learning effects, we used the practice-adjusted reliable change index for assessing the cognitive changes.

Results:

Preablation cognitive impairment was detected in 18.5% (57/308). The Montreal Cognitive Assessment score significantly improved 1 year after radiofrequency catheter ablation in both overall ablation group (24.9±2.9–26.4±2.5;
P
<0.001) and the propensity-matched ablation group (25.4±2.4–26.5±2.3;
P
<0.001), but not in the control group (25.4±2.5–24.8±2.5;
P
=0.012). Preablation cognitive impairment (odds ratio, 13.70; 95% CI, 4.83–38.87;
P
<0.001) was independently associated with an improvement in the 1-year post-ablation cognitive function. In the reliable change index analyses, 94.7% of propensity-matched ablation group showed an improved/stable cognitive function at the 1-year follow-up.

Conclusions:
Catheter ablation of AF, at least, does not deteriorate the cognitive function, but rather improves the performance on 1-year follow-up neurocognitive tests, especially in patients with a preablation cognitive impairment.
How Things Happen for the Sake of Something: The Dialectical Strategy of Aristotle, Physics 2.8
Authors: Kress Emily 
Published: July 2019

AbstractI offer a fresh interpretation of the dialectical strategy of Physics 2.8’s arguments that things in nature happen for the sake of something. Whereas many recent interpreters have concluded that these arguments inevitably beg the question against Aristotle’s opponents, I argue that they constitute a careful attempt to build common ground with an opponent who rejects Aristotle’s basic worldview. This common ground, first articulated in the famous Winter Rain Argument, takes the form of an intriguing pattern of reasoning: that natural proceedings that happen in a given manner always or for the most part do not do so by chance.
To Rot and Not to Die: Punitive Emasculation in Early and Medieval China
Authors: Hoeckelmann Michael 
Published: July 2019

AbstractHistorians agree that the primary source of supply for eunuchs in late imperial China was not the penal system but self-emasculation. What is less known is that the legal institution of punitive emasculation and the political institution of court eunuchs were separated long before then. While some scholars argue that emasculation was not among the mutilating punishments that Han Emperor Wen abolished in 167 BCE, there is enough evidence to show that the Han court no longer used it as a regular punishment after his reign and that Wen had indeed done away with emasculation. In fact, it was the non-Chinese Northern Wei dynasty that reintroduced it centuries later, from whence it continued to be used intermittently until the late seventh century.
Provincializing Korea: The Construction of the Chinese Empire in the Borderland and the Rise of the Modern Chinese State
Authors: Wang Yuanchong 
Published: July 2019

AbstractThis article examines China’s approach to integrating Korea into Chinese territory in history and its significant influence on the construction of the Chinese Empire and state. It discusses major instances of Chinese integration of Korea before and under the Mongol Empire and reveals that the tributary relationship with Korea that the Ming and Qing dynasties cultivated in the post-Mongol period allowed Korea to maintain a significant degree of independence from China. It points out that the Qing imperial discourse described Korea as a province by combining the Manchu ruling house’s and European Jesuits’ understandings of the Chinese empire. Qing China refrained from colonizing Korea in the nineteenth century primarily because of the post-Mongol shift in its policy toward the country and because of its Confucian ethos. The article further argues that China did not become a modern state until the 1950s, when the Chinese option of provincializing Korea permanently disappeared.
Is a ‘Left Populism’ Possible?
Authors: Sotiris Panagiotis 
Published: July 2019

Abstract
This article deals with theories and political projects that can be defined as ‘left populism’. It begins with a reading and critique of the work of Ernesto Laclau on the theory of populism and then moves to recent debates about the possibility of left-populist movements. In contrast to these positions it attempts to present an alternative theoretical framework based on Gramscian notions, in order to rethink the notion of the people in ways that do not de-link it from class analysis and social relations of production.
Marx’s Social Republic: Political not Metaphysical
Authors: Roberts William Clare 
Published: July 2019

Abstract
When Marx dissected the capitalist economy and intervened in the international workers’ movement, he did so in the service of freeing people from alien, uncontrolled power. His political project was the realisation of what he called the social republic, and his theoretical project was to identify the forces that promote or retard this political project. In order to bring out the specificity and cogency of the social-republican Marx, this essay uproots the positive-freedom reading that has overgrown the edifice of his thought. Marx certainly hoped for ‘real freedom’, which is a sort of self-realisation. He also hoped for a sort of collective self-determination. And he thought that collective self-determination was a prerequisite for general self-realisation. But Marx also thought that generalised freedom from domination was a prerequisite for collective self-determination.
Nominal vs copular clauses in a diachronic corpus of Ancient Greek historians
Authors: Mambrini Francesco 
Published: July 2019

AbstractWe study the distribution of the nominal and copular construction of predicate nominals in a subset of authors from the Ancient Greek Dependency Treebank (AGDT). We concentrate on the texts of the historians Herodotus, Thucydides (both 5th century BCE) and Polybius (2nd century BCE). The data comprise a sample of 440 sentences (Hdt = 175, Thuc = 91, Pol = 174). We analyze the impact of four features that have been discussed in the literature and can be observed in the annotation of AGDT: (1) order of constituents, (2) part of speech of the subjects, (3) type of clause and (4) length of the clause. Furthermore, we test how the predictive power of these factors varies in time from Herodotus and Thucydides to Polybius with the help of a logistic-regression model. The analysis shows that, contrary to a simplistic opinion, the nominal construction does not drop into irrelevance in Hellenistic Greek. Moreover, an analysis of the distributions in the authors highlights a remarkable continuity in the usage patterns. Further work is needed to improve the predictive power of our logistic-regression model and to integrate more data in view of a more comprehensive quantitative diachronic study.
The Practicality of Holiness
Authors: Delgado Dara 
Published: July 2019

Abstract
In the second edition of the book African American Religion: Varieties of Protest and Accommodation, Hans A. Baer and Merrill Singer explore the relationship between Black Holiness–Pentecostalism and social activism. Ultimately, the authors conclude this portion of their study by asserting that “the vast majority of African American conversionist sects [among which they include Black Holiness–Pentecostalism] remain apolitical in their posture toward the larger society.” The idea is that Black Holiness–Pentecostals tend to put more emphasis on socially approved behaviors, attitudes, work ethic, and styles of dress than on engaging in socioeconomic and political affairs. This article considers Baer and Singer’s claim that Black Holiness–Pentecostals have historically tended to be apathetic toward worldly concerns and puts that claim into conversation with the life and work of Ida Bell Robinson, founder of the Mt. Sinai Holy Church of America (1925–1946). I explore the issues of class, race, and gender in relation to holiness. Moreover, I contend that the distinct practices of early Black Holiness–Pentecostals proved critical to living a sanctified, or clean, life and also determined the ways local churches addressed and worked to remedy problems around poverty (both social and economic) in their communities.
The Marco Cappato and Fabiano Antoniani (dj Fabo) Case Paves the Way for New Assisted Suicide Legislation in Italy: An Overview of Statutes from Several European Countries
Authors: Montanari Vergallo Gianluca 
Published: July 2019

Abstract
The article looks into the case involving Fabiano Antoniani, who, following a major road accident, was left tetraplegic. Marco Cappato drove him to a Swiss clinic where Mr. Antoniani took his own life by self-administration of lethal pentobarbital sodium. Cappato was put on trial, but the Italian Constitutional Court urged the Parliament to decriminalise assisted suicide in extremely serious cases. From a comparison with other European countries, approaches range from restrictive (banning both active euthanasia and assisted suicide), to entirely permissive. An intermediate approach only entails a ban on active euthanasia. It would be desirable to uniformise the diverse national statutes on a European level, which would make it possible for everyone to receive assistance towards ending their suffering, with limitations to incurable cases to be medically verified, and at the end of a path designed to ensure that patient freedom of choice is upheld at all time.
Reflections on Literary Studies in South Africa
Authors: Wittenberg Hermann 
Published: July 2019

Abstract
Zakes Mda is not only one of South Africa’s most significant post-apartheid novelists, but has worked in diverse media such as theatre, film, opera, painting and music. His prolific creativity in forms other than the novel needs to be taken into account when evaluating his writings. This article proposes an intermedial analysis of Black Diamond (2009), a novel which has largely been given unfavourable critical attention, and suggests that it needs to be considered as a mixed medial text that is shaped by a cinematic mode of narration. The novel is also re-interpreted in the light of a postcolonially inflected “surface reading,” which makes the pervasive visuality of Mda’s prose visible. Finally, it is argued that texts such as Black Diamond raise questions about the interpretive methodologies and reading practices in English literary studies, pointing to future challenges and opportunities in the discipline.
From the Autonomy Framework towards Networks and Systems Approaches for ‘Autonomous’ Weapons Systems
Authors: Liu Hin-Yan 
Published: July 2019

The legal debate surrounding the development and deployment of autonomous weapons systems (aws) has stagnated in recent years, having arguably hit the hard limits of legal doctrine. At the heart of this impasse lies the focus upon autonomy as both the innovative and defining feature of aws. Thus, the autonomy of the weapons system places it in a legally liminal zone between agent and object, revealing a set of legal problems that revolve around issues of control, influence, responsibility and liability, and questions of legal compliance that follow from the prospect of autonomous lethal decision-making.
This paper seeks to explore alternative framings to the same underlying technology as a means of escaping the limits imposed by the autonomy framework that has dominated the debate to date, and to examine the consequences that flow from pursuing these approaches from legal and regulatory perspectives. In particular, emphasis is placed upon the networks approach, and the systems approach, which this paper sets out and differentiates from the orthodox emphasis upon autonomy. These alternative approaches suggest that the legal problems arising from the autonomy framing are the easiest set of issues to address, insofar as these frame legal problems, while the networks and systems approaches seem to touch upon legal mysteries to which no ready legal or regulatory responses can be made. Rather than dismiss the network and systems approaches, however, this paper suggests that appropriate, adequate and robust legal and regulatory responses must consider the insights and challenges that these approaches pose, and that pursuing these approaches will lead to powerful converging arguments supporting a moratorium on the deployment of aws.
Dimensions of Multiplicity: New Perspectives on Turkish Muslim Community Centres in Germany as Relational Space
Authors: Herz Kathrin , Munsch Chantal 
Published: July 2019

Abstract
The paper is based on an ethnographic study of Turkish Muslim Community Centres in Germany. It analyses the multiplicity of these centres at various levels on the basis of participant observations, interviews, plans and photographs. The article describes the multiplicity of religious, cultural, social and commercial functions in the multifunctional clusters that are constantly changing. It clearly shows how individual spaces house a variety of overlapping social practices and how users associate diverse meanings with the centres. The paper develops a new perspective on mosques by focusing on the space and the complexity of everyday routines.
Critics, Moralists and Intellectuals: The Transformation of the Udabāʾ in the Arab Nahḍah: a Historical-Conceptual Approach
Authors: Pepe Teresa 
Published: July 2019

Abstract
This article analyzes the importance of the Nahḍah (Arabic Renaissance) for current developments in the field of Arabic literature. In particular it links the contemporary debate concerning the role and nature of writers and intellectuals (udabāʾ) in Arabic society to the semantic transformations undergone by the term adīb during the Nahḍah.
The study analyses a number of statements made by Egyptian writers in the historical cultural press, critical essays, and ̩̩literary works, in which the term adīb is discussed, using R. Koselleck’s method of conceptual history. It shows that, during the Nahḍah, the term absorbed the European concepts of “author”, “man of letter”, “intellectual”. Nonetheless, the classical meanings of adīb as a subject associated with eloquence, encyclopaedic knowledge and moralistic attitude, were also revived, and this spurred a lively debate characterized by plurality of views and intellectual dispositions.
Linking the nahḍawī debates to the debate concerning writers and intellectuals (udabāʾ) in contemporary society, the article shows how these same meanings are being re-disputed today in the midst of global and local cultural transformations.
Distribution of lignin, pectins and hemicelluloses in tension wood fibers of European ash (Fraxinus excelsior)
Authors: Kim Jong Sik , Daniel Geoffrey 
Published: July 2019

ABSTRACT
Although there is considerable information on the chemistry of gelatinous (G) layers in tension wood (TW) fibers consisting of S1 + S2 + G cell wall structure (poplar), little is known on the chemistry of G-layers in TW fibers organized with S1+ G structure. This study investigated the distribution of lignin and non-cellulosic polysaccharides in ash TW fibers (S1+ G) using histochemistry and immunolocalization methods. TW fibers studied were fully developed (mature fibers) and obtained from two (TW-1, TW-2) mature European ash trees (Fraxinus excelsior L.). Based on differences in microfibril angle (MFA) and TW trees used, TW fibers were mainly classified into three types; 1) Type-1 fibers with MFA almost parallel to the fiber axis that were found in TW-1, 2) Type-2 fibers with 12° MFA that were abundant at the end of growth rings of TW-1 and 3) Type-3 fibers with 10° MFA that were found in TW-2. The S3 layer was absent in all TW fibers. In this study, the secondary cell wall structure of Type-1 and Type-2/Type-3 fibers were defined as G and GL (gelatinous-like) layers, respectively. Lignin with syringyl (S) units was detected in G/GL-layers, in which intensity and patterns of lignin staining likely related to the difference in MFA between G- and GL-layers. With hemicelluloses, heteroxylan and heteromannan epitopes were detected in G/GL-layers but these were much less abundant than those in S2 layers of normal wood (NW) fibers. Like lignin, distribution patterns of heteromannan epitopes in G/GL-layers likely related to differences in MFA between fiber types. Sparse xyloglucan epitopes were also detected in G/GL-layers. Homogalacturonan epitopes were absent in G/GL-layers. All fiber types showed abundant a-1, 5-arabinan epitopes in G/GL-layers. Overall results indicate that the chemistry of ash TW fibers studied differs significantly from that of other species reported previously, specifically TW fibers composed of S1 + S2 + G structure.
The Origin of the Northern Tungusic Generalizing Particle *-gal ~ *-wal
Authors: de la Fuente José Andrés Alonso 
Published: July 2019

Abstract
The paper presents a survey of the generalizing clitical particle documented in Northern Tungusic in the forms -wal, -mal, -gal, -wul, -ul, etc., which, in some languages, is also attested in the function of the disjunctive conjunction ‘either—or’. Focusing on the dialectological and diachronic explanation of the initial alternation of w and g in this particle, the paper brings forth arguments in favour of the hypothesis that these elements are ultimately connected with the verbal root gǝlǝǝ- ‘to want, to please, to look for’. The conclusion is of general typological interest, and well-known parallels for the proposed development can be found in, for instance, several European languages.
Change in Relationship between the East Asian Winter Monsoon and the East Asian Jet Stream during the 1998–99 Regime Shift
Authors: Song Se-Yong , Yeh Sang-Wook , Park Jae-Heung 
Published: June 2019

Abstract
A composite analysis was conducted on the reanalysis dataset for 1979–2016, along with an idealized model experiment to show that the relationship between the East Asian jet stream (EAJS) and the East Asian winter monsoon (EAWM) is nonstationary. The relationship between EAWM and the EAJS weakened during the late 1990s. This decadal change in the EAJS–EAWM relationship was mainly due to a change in the secondary circulation across the EAJS between two contrasting periods, induced by the northward shift of the EAJS. A possible mechanism associated with the decadal change in meridional displacement of the EAJS is proposed. The enhanced convective activity in the western tropical Pacific after the late 1990s results in stronger Hadley circulation that could have contributed to the northward displacement of the Hadley circulation boundary latitude. Subsequently, this leads to the northward shift of the EAJS. Therefore, it is necessary to define a new EAJS index to account for the EAWM variability based on the change in the oceanic and atmospheric mean state across the late 1990s.
Some Expectations for Submesoscale Sea Surface Height Variance Spectra
Authors: Callies Jörn , Wu Weiguang 
Published: June 2019

AbstractIn anticipation of the Surface Water and Ocean Topography (SWOT) wide-swath altimetry mission, this study reviews expectations for sea surface height (SSH) variance spectra at wavelengths of 10–100 km. Kinetic energy spectra from in situ observations and numerical simulations indicate that SSH variance spectra associated with balanced flow drop off steeply with wavenumber, with at least the negative fourth power of the wavenumber. Such a steep drop-off implies that even drastic reductions in altimetry noise yield only a modest improvement in the resolution of balanced flow. This general expectation is made concrete by extrapolating SSH variance spectra from existing altimetry to submesoscales, the results of which suggest that in the extratropics (poleward of 20° latitude) SWOT will improve the resolution from currently about 100 km to a median of 51 or 74 km, depending on whether or not submesoscale balanced flows are energetic. Internal waves, in contrast to balanced flow, give rise to SSH variance spectra that drop off relatively gently with wavenumber, so SSH variance should become strongly dominated by internal waves in the submesoscale range. In situ observations of the internal-wave field suggest that the internal-wave signal accessible by SWOT will be largely dominated by internal tides. The internal-wave continuum is estimated to have a spectral level close to but somewhat lower than SWOT’s expected noise level.