bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA-198 inhibits proliferation and induces apoptosis by directly suppressing FGFR1 in gastric cancer
Authors: Gu Junxia , Li Xiaozhen , Li Hui , Jin Zhe , Jin Jianjun 
Published: May 2019

Abstract
MicroRNAs (miRNAs) are increasingly recognized as important therapeutic targets in cancer. Here we aim to investigate the role of miR-198, a broad-spectrum tumor suppressor, in gastric cancer (GC). MiR-198 overexpression was achieved by transfection of miR-198 mimics, followed by evaluation of cell viability using cell-counting kit 8. Cell cycle arrest and apoptosis were assessed by Annexin-V-FITC/Propidium Iodide (PI) staining flow cytometry respectively. The target of miR-198 was identified by bioinformatical analysis and confirmed by dual-luciferase assay, along with real-time PCR and Western blot analyses of target gene expression after transfection of miR-198 mimics. GC tissues were characterized by miR-198 down-regulation. Restoration of miR-198 expression attenuated GC cell proliferation and colony formation, meanwhile inducing significant G0/G1 arrest. Furthermore, combinatory therapy of cisplatin and miR-198 induced greater anti-tumor effects than treatment with cisplatin single therapy. We also identified fibroblast growth factor receptor 1 (FGFR1) as a direct target gene of miR-198. Furthermore, FGFR1 silencing elicited a similar tumor-suppressive effect as miR-198 overexpression. FGFR1 overexpression antagonized the anti-tumor effects of miR-198 overexpression. MiR-198/FGFR1 axis plays an important role in proliferation and apoptosis of GC. Therapies targeted to miR-198 can potentially improve GC treatment.
Increased incidence of second primary malignancy in patients with malignant astrocytoma: a population-based study
Authors: Wang Wenming 
Published: May 2019

Abstract
We identified patients diagnosed with malignant astrocytoma (MA) as the first of two or more primary malignancies between 1973 and 2015 from Surveillance, Epidemiology and End Results (SEER) database. Multiple primaries-standardized incidence ratio (MP-SIR) was calculated to quantitate the risk of second primary malignancy (SPM). We further identified the risk factors of developing SPM and factors affecting overall survival (OS) in MA patients with SPM. Our results revealed that overall risk of SPM among MA patients was significantly higher than that in general population (SIR: 1.09, 95% confidence interval (CI): 1–1.18, P&lt;0.05). Specific sites where the risk of SPM increased included salivary gland, bone and joints, soft tissue including heart, brain, cranial nerves other nervous system, thyroid, acute non-lymphocytic leukemia and acute myeloid leukemia. Overall risk of SPM in patients aged ≤29 and 30–59 years significantly increased (4.34- and 1.41-fold respectively). Whereas patients aged ≥60 years had a significantly decreased risk of SPM. Patients in the group of latency at 36–59, 60–119 and ≥120 months carried significantly increased overall risk of SPM. Multivariate analysis revealed that age, race, marital status, WHO grade, differentiated grade of cancer tissues, latency was independent predictor of OS in MA patients with SPM, which were all selected into the nomogram. The calibration curve for probability of survival showed good agreement between prediction by nomogram and actual observation. In conclusion, MA survivors should be advised of their increased risk for developing certain cancers in their lifetime. Our study had clinical implications for the surveillance of MA survivors at risk of developing SPM.
Overexpression of IGFBP2 mRNA predicts poor survival in patients with glioblastoma
Authors: Yuan Qing , Cai Hong-Qing , Zhong Yi , Zhang Min-Jie , Cheng Zhi-Jian , Hao Jia-Jie , Wang Ming-Rong , Wan Jing-Hai 
Published: May 2019

Abstract
The prognosis of patients with glioblastoma (GBM) is dismal. It has been reported that Insulin-like growth factor (IGF) binding protein 2 (IGFBP2) is associated with the mobility and invasion of tumor cells. We investigated the expression of IGFBP2 mRNA in GBMs and its clinical relevance, using tissue microarrays and RNAscope in situ hybridization in 180 GBMs and 13 normal or edematous tissues. The correlations between the expression and clinical pathological parameters as well as some other biomarkers were analyzed. Overexpression of IGFBP2 mRNA was observed in 23.9% of tumors tested. No expression of IGFBP2 mRNA was detected in normal or edematous tissues. Kaplan–Meier survival analysis showed that the survival time of all the patients with high IGFBP2 tumors had shorter survival than those with low IGFBP2 (P&lt;0.01). Univariate regression and multivariate regression both indicated that the expression of IGFBP2 transcript level was an independent prognostic factor (P=0.008 and 0.007, respectively). Furthermore, expression of IGFBP2 mRNA was related to the occurrence of isocitrate dehydrogenase 1 (IDH1) mutation, high heat shock protein 27 (Hsp27) expression and telomerase reverse transcriptase (TERT) promoter mutation (TERTp+) (P=0.013, 0.015 and 0.016, respectively), and patients with TERTp+/IGFBP2high showed the shortest survival. In conclusion, IGFBP2 mRNA expression status is an independent prognostic biomarker in GBMs, and the combination of IGFBP2 mRNA and TERTp status might serve as a prognostic indicator in patients with GBM.
Arbeiten mit multinationalen Teams
Authors: Eßrich Marie-Luise 
Published: May 2019

Immer mehr Kliniken greifen auf ausländische Pflegende zurück, um ihre Versorgungslücken zu schließen – auch die Charité. Mit einem gut durchdachten Akquise- und Integrationsmanagement holt sie Pflegende aus Albanien und Mexiko an Bord.
Update Mammakarzinom 2019 Teil 3 – aktuelle Entwicklungen bei der kurativen Behandlung von Mammakarzinompatientinnen: eine Übersicht und Bewertung durch ein internationales Expertenpanel
Authors: Kolberg Hans-Christian , Schneeweiss Andreas , Fehm Tanja N. , Wöckel Achim , Huober Jens , Pontones Constanza , Titzmann Adriana , Belleville Erik , Lux Michael P. , Janni Wolfgang , Hartkopf Andreas D. , Taran Florin-Andrei , Wallwiener Markus , Overkamp Friedrich , Tesch Hans , Ettl Johannes , Lüftner Diana , Müller Volkmar , Schütz Florian , Fasching Peter A. , Brucker Sara Y. 
Published: May 2019

ZusammenfassungDie Behandlung von Mammakarzinompatientinnen in der kurativen Situation ist in vielfacher Hinsicht besonders. Die lokale Therapie mit Operation und Strahlentherapie ist zentraler Aspekt der Behandlung. Ziel ist eine komplette Elimination aller Tumorzellen am Ort der Primärerkrankung bei gleichzeitigem Bestreben, die Langzeitfolgen so gering wie möglich zu halten. Die immer weitere Reduktion der Radikalität der Lokaltherapie steht auch weiterhin im Blickpunkt. In Bezug auf die Systemtherapie haben sich in den letzten beiden Jahrzehnten Chemotherapien mit Taxanen, Anthrazyklinen und teilweise auch platinhaltigen Chemotherapien etabliert. Der Kontext der Nutzung wird immer genauer definiert. Ebenso gibt es bei der antihormonellen Therapie Fragen, die auch nach Einführung der Aromatasehemmer immer noch weiter definiert werden müssen, wie beispielsweise die Länge der Therapie oder die ovarielle Suppression bei prämenopausalen Patientinnen. Letztlich soll die Behandlung von frühen Mammakarzinompatientinnen immer personalisierter werden. Prognostische Genexpressionstests könnten möglicherweise Therapieentscheidungen unterstützen. Ebenso muss überlegt werden, wie ein möglicher Einsatz von neuen Therapien wie Checkpointinhibitoren und CDK4/6-Inhibitoren in der Praxis aussehen könnte, sobald dazu Studienergebnisse vorliegen. Diese Übersichtsarbeit beschäftigt sich mit den Hintergründen zu aktuellen Abstimmungen, die das internationale St.‑Gallen-Expertenpanel in Wien 2019 für aktuelle Fragen in der Behandlung von Mammakarzinompatientinnen in der kurativen Situation vorgenommen hat.
Unterstützende Infusionen in der integrativen Onkologie bei Brustkrebs und gynäkologischen Krebserkrankungen – Bericht über die Zufriedenheit der Patientinnen sowie über selbstberichtete Wirkungen und Nebenwirkungen
Authors: Hack Carolin C. , Antoniadis Sophia , Beckmann Matthias W. , Brandl Anna Lisa , Fasching Peter A. , Hackl Janina , Langemann Hanna , Katja Stock , Weber Natalie , Theuser Anna-Katharin 
Published: May 2019

Zusammenfassung
Hintergrund Während einer Krebstherapie leiden viele Patienten an Mangelernährung oder Vitaminmangel. Die Behandlung nährstoffbezogener Mangelzustände sollte daher eine Ernährungstherapie und gegebenenfalls auch eine orale oder intravenöse Substitution von Mikronährstoffen beinhalten. Über Infusionstherapien mit mehreren Nährstoffen liegen nur wenige Informationen vor. Das Ziel dieser Studie bestand in der Entwicklung standardisierter Infusionsprotokolle für die Infusion von Mikronährstoffen im Rahmen der integrativen Medizin (IMed-Infusionen) und der Beschreibung von Nebenwirkungen der Behandlung und der Therapiezufriedenheit der Patientinnen.
Methoden Für die IMed-Sprechstunde wurden in Zusammenarbeit mit der Apotheke des Universitätsklinikums Erlangen 4 spezielle Formulierungen für die intravenöse Anwendung entwickelt. Zwischen Oktober 2015 und Januar 2018 wurde eine retrospektive Querschnittsstudie durchgeführt, in der 45 Patientinnen mit gynäkologischen Krebserkrankungen oder Brustkrebs (BK) unter IMed-Infusionstherapie aufgenommen wurden. Von 20 Patientinnen wurden mithilfe eines standardisierten Fragebogens zu IMed-Infusionen Nachbeobachtungsdaten erhoben.
Ergebnisse Während des Studienzeitraums wurden insgesamt 280 IMed-Infusionen verabreicht. Die meisten Patientinnen haben IMed-Regenerationsinfusionen erhalten (78 %). Die Patientinnen litten in der Mehrzahl der Fälle an BK und wurden mit Chemotherapie behandelt. Die meisten Patientinnen gaben ein hohes oder sehr hohes Maß an Zufriedenheit mit der Organisation (60 %), der allgemeinen Behandlung (65 %) und der Beratung (85 %) an. Über eine subjektive Besserung von krankheits- oder therapiebedingten Symptomen wie Fatigue, Polyneuropathie und Einschränkung der körperlichen Leistungsfähigkeit berichteten 70 % der Patientinnen, während 75 % eine subjektive Steigerung ihrer Lebensqualität angaben. Nebenwirkungen traten nur selten auf und waren leichter Natur.
Schlussfolgerungen Die Therapie mit IMed-Infusionen bei Frauen mit BK oder gynäkologischen Krebserkrankungen muss denselben Standards genügen wie Arzneimitteltherapien. Obwohl es sich bei Vitaminen um Nahrungsergänzungsmittel handelt, sind eine gründliche Erhebung der Anamnese sowie eine angemessene Aufklärung der Patientinnen unerlässlich. Hierfür haben sich standardisierte Vorgehensweisen, wie im Rahmen der IMed-Sprechstunde der Fall, als hilfreich erwiesen.
Spezialisierte Ambulante Palliativ-Versorgung
Authors: Nauck Friedemann , Jansky Maximiliane 
Published: May 2019

ZusammenfassungZiel der Spezialisierten Ambulanten Palliativ-Versorgung (SAPV) ist es, die Selbstbestimmung und Lebensqualität schwer belasteter Patienten am Lebensende zu stärken. Diese bundesweite Leistung ermöglicht Unterstützung bei besonders komplexen physischen und psychosozialen Belastungssituationen und bietet eine multiprofessionelle, häusliche Behandlung in Kooperation mit Primärversorgern.
Systemic Sclerosis Associated Interstitial Lung Disease: A Comprehensive Overview
Authors: Mackintosh John A. , Stainer Anna , Barnett Joseph L. , Renzoni Elisabetta A. 
Published: May 2019

AbstractInterstitial lung disease (ILD) is a common complication of systemic sclerosis (SSc). SSc-ILD adversely impacts quality of life and is currently the leading cause of death in this multisystem disease. Identifying clinically significant SSc-ILD is critically important. Accurate staging and prognostication remain difficult; however, significant advances have been made in the last decade. Evidence supports the need to treat patients with extensive and/or progressive SSc-ILD, while only a subset of patients with limited ILD may require treatment. Research is urgently required to allow improved prediction of patients at risk of ILD progression at an early point in the disease, and ideally prior to its onset, to allow prevention. The last decade has seen the publication of landmark clinical trials for SSc-ILD. More effective strategies with less toxicity are under investigation. For those with refractory or very advanced disease, studies into disease-specific palliative approaches are in their infancy. Lung transplantation as an option for SSc-ILD remains patient- and center-specific, with data to suggest equivalent outcomes to other fibrotic lung diseases, in carefully selected cases. This review aims to provide a comprehensive overview of all key aspects of SSc-ILD.
Pulmonary and Bronchiolar Involvement in Sjogren's Syndrome
Authors: Chung Augustine , Wilgus May Lin , Fishbein Gregory , Lynch Joseph P. 
Published: May 2019

AbstractSjogren's syndrome (SS) is a chronic autoimmune disease characterized by mononuclear cells (principally lymphocytes) infiltrating exocrine glands (e.g., salivary and lacrimal glands), leading to destruction of exocrine epithelial cells and dryness of mucosal surfaces. Cardinal symptoms are dry eyes (xerophthalmia) and dry mouth (xerostomia). Extraglandular sites are affected in 30 to 40% of cases of SS (particularly neurological, kidneys, skin, and lungs). B cell hyperactivity, autoantibody production, and hypergammaglobulinemia are cardinal features of SS. Primary SS is not associated with other autoimmune diseases. However, SS can complicate diverse autoimmune disorders (particularly systemic lupus erythematosus, rheumatoid arthritis, and scleroderma); this form is termed “secondary SS.” Pulmonary involvement is usually not a dominant feature of SS, but may be severe in some cases. In this review, we discuss specific tracheal, bronchiolar, and pulmonary complications of SS including xerotrachea, bronchiolitis, bronchiectasis, interstitial lung disease, nonspecific interstitial pneumonia, usual interstitial pneumonia, lymphoid interstitial pneumonia, organizing pneumonia, acute fibrinous and organizing pneumonia, pulmonary cysts, pleural effusions, pulmonary amyloidosis, and bronchus- or lung-associated lymphomas.
Arthrographic Study of the Communication between the Tarsal Joints in Crioulo Horses
Authors: Gehm Marcelo V. , Duarte Claudia A. , Leite Carla T. , Góss Geórgia C. , Döwich Gabriela , Pereira Elton P. , da Rosa Loreane R. , Romero Bruno G. 
Published: May 2019

Abstract
Objective The aim of the present study is to assess an arthrographic technique based on the access to the equine tarsus via distal intertarsal and on the existence and frequency of communication between distal and tarsocrural joints in the tarsus of Crioulo horses.
Materials and Methods Fifty Crioulo horses of both sexes from 3 to 8 years old were included in the experiment. Animals with radiographic signs of tarsal osteoarthritis and joint space loss were excluded from the experiment. Contrast was injected in the distal intertarsal joint and radiographs were taken at two different times - Time 0 (after contrast application) and Time 1 (45 seconds after) to detect any communication between tarsal joints. The recorded results were analysed through chi-squared test.
Results Thirty out of three hundred tarsi were excluded from the experiment since the radiographic images showed loss of the distal intertarsal joint space. Positive contrast was injected in distal intertarsal joint of 70/100 tarsi. There was not any contrast overflow in the 30/70 assessed tarsi. Contrast diffused to the tarsometatarsal joint in 32/70 of the assessed tarsi and reached tarsocrural joints in 8/70 tarsi. The adopted arthrographic technique was effective in data collection and evaluation; however, 52/70 of tarsi showed contrast overflow to the bursa of the cunean tendon.
Clinical significance The communication between tarsocrural and distal tarsal joints in Crioulo horses was significantly higher, and this finding emphasizes the importance of performing contrasted arthrography before getting to a final diagnostic and defining therapeutic procedures.
Girls’ perceptions of boys with violent attitudes and behaviours, and of sexual attraction
Authors: Puigvert Lidia , Gelsthorpe Loraine , Soler-Gallart Marta , Flecha Ramon 
Published: May 2019

AbstractViolence against women is a reality that is still present in Europe and a serious public health threat worldwide. Fortunately, investment is being made to raise awarness at the national and EU levels and among diverse publics. However, more research is needed in order to better explain its underlying factors, and thus identify effective actions that could contribute to preventing young girls and women from becoming victims. Drawing on a theoretical approach to the preventive socialization of gender violence, in this study we report data from the quasi-experimental research project ‘Free Teen Desire’ (Marie Sklodowska-Curie Grant, 2015–2016, No 659299). Through a survey conducted on 100 female adolescents (aged 13–16) in different European secondary schools (in England, Spain, Cyprus and Finland), we analysed their pattern of attraction for both ‘hooking up’ and stable relationships towards boys with either violent attitudes and behaviour or boys with non-violent behaviour, what would be linked to gender violence victimization at a later stage in their lives. Our findings suggest that in the different European secondary schools studied, a similar pattern of attraction is recognized by female participants: although non-violent boys are highly preferred to those with a violent profile, we observed that boys with violent attitudes and behaviours are mostly preferred for hooking up, and boys with non-violent traits are mostly preferred for stable relationships. In addition to the novelty of providing quantitative data on these links (non-violent/stable relationships; violent/hook-ups) in the case of adolescents, the findings regarding the pattern of attraction towards boys with violent traits for sporadic relationships are in line with previous extensive qualitative research. This body of research marks the existence of a coercive dominant discourse that associates attraction with violence and influences the socialization processes of many girls during their sexual-affective relationships’ awakening, which has been shown to constitute a risk factor for gender violence victimization.
The data politics of the urban age
Authors: Duarte Fábio , Álvarez Ricardo 
Published: May 2019

AbstractThe deployment of myriad digital sensors in our physical environments is generating huge amounts of data about the natural and built environments and about ourselves, social relations, and interactions in space. These unprecedented quantities of data combine with high-performance computers to produce a series of increasingly powerful tools ranging from mathematical modeling on a massive scale to various types of artificial intelligence. Within this context, urban planning and design driven by data and predictive tools have been gaining traction. This scientific approach to urban problems echoes the nineteenth-century birth of modern urbanism, when rapid industrialization and new scientific methods were advocated against a traditional beaux-arts approach to city planning; and the twentieth century proved that such scientific methods were politically charged. Arguing that we are facing a similar breakthrough in urban studies and planning, in this paper we discuss how data-driven approaches can foster urban studies, but must be balanced with a critical view to the inherent social values of cities.
Transforming evidence for policy and practice: creating space for new conversations
Authors: Oliver Kathryn , Boaz Annette 
Published: May 2019

AbstractFor decades, the question of how evidence influences policy and practice has captured our attention, cutting across disciplines and policy/practice domains. All academics, funders, and publics have a stake in this conversation. There are pockets of great expertise about evidence production and use, which all too often remains siloed. Practical and empirical lessons are not shared across disciplinary boundaries and theoretical and conceptual leaps remain contained. This means that we are not making the most of vast and increasing investment in knowledge production. Because existing lessons about how to do and use research well are not shared, funders and researchers are poorly equipped to realise the potential utility of research, and waste resources on—for example—ineffective strategies to create research impact. It also means that the scarce resources available to study evidence production and use are misspent on overly-narrow or already-answered questions. Patchy and intermittent funding has failed to build broadly relevant empirical or theoretical knowledge about how to make better use of evidence, or to build the communities required to act on this knowledge. To transform how we as a community think about what evidence is, how to generate it, and how to use it well, we must better capture lessons being learned in our different research and practice communities. We must find ways to share this knowledge, to embed it in the design of our research systems and practices, and work jointly to establish genuine knowledge gaps about evidence production and use. This comment sets out one vision of how that might be accomplished, and what might result.
Historical roots of implicit bias in slavery
Authors: Payne B. Keith , Vuletich Heidi A. , Brown-Iannuzzi Jazmin L. 
Published: May 2019

Significance
Geographic variation in implicit bias is associated with multiple racial disparities in life outcomes. We investigated the historical roots of geographical differences in implicit bias by comparing average levels of implicit bias with the number of slaves in those areas in 1860. Counties and states more dependent on slavery in 1860 displayed higher pro-White implicit bias today among White residents and less pro-White bias among Black residents. Mediation analyses suggest that historical oppression may be transmitted into contemporary biases through structural inequalities, including disparities in poverty and upward mobility. Given the importance of contextual factors, efforts to reduce unintended discrimination might focus on modifying social environments that cue implicit biases in the minds of individuals.
Motor primitives are determined in early development and are then robustly conserved into adulthood
Authors: Yang Qi , Logan David , Giszter Simon F. 
Published: May 2019

Significance
We show that major differences in postnatal experience and development do not impact the fundamental deep structure of motor primitives generated in the spinal cords of mammals. We show that the availability of core synergy structures/primitives persists into adulthood. These synergy structures in lumbar spinal cord are revealed to be closely similar among all individuals despite different motor experiences and capabilities [postnatal day 5 (P5) vs. adult transections] after a complete spinal cord transection. This similarity of synergy set after spinal transection could arise, because the synergy circuitry is fully determined at P5, because the circuitry development is equifinal despite the P5 isolation from brain, or because the circuitry plasticity converges on the same synergies after each transection.