bluuebunny/crossref_metadata_2025_split huggingface dataset:
Base heat flux measurement techniques in impulse hypersonic test facilities
Authors: Irimpan Kiran J. , Menezes Viren , Srinivasan K. 
Published: July 2019

AbstractSafe and efficient hypersonic missions require exhaustive testing to capture the surface heat flux used in optimizing thermal protection systems. Though low, base heat transfer rates are still relevant and their estimation is of the utmost importance. Impulse hypersonic test facilities like the shock tunnel are commonly used for such estimation tests. The present paper compares contemporary heat flux measurement techniques, namely, E‐type coaxial thermocouples, Pt‐thin films, and atomic layer thermopiles in a hypersonic shock tunnel at the base of a scaled‐down re‐entry capsule. Base flow establishment is ensured using pressure measurements. The measurements indicated that the base‐stagnation point heat flux was approximately 2% to 3% of the forebody stagnation heat flux and it stabilized at an approximate nondimensional establishment time of 43.2 ± 2.4.
Nongray inverse boundary design problems in enclosures at radiative equilibrium
Authors: Amiri Hossein , Lari Khosro 
Published: July 2019

AbstractIn this paper, an inverse analysis is used to find an appropriate heat flux distribution over the heater surface of radiant enclosures, filled with nongray media at radiative equilibrium from the knowledge of desired (prespecified) temperature and heat flux distributions over the given design surface. Regular and irregular 2D enclosures filled with nongray combustive gas products are considered. Radiation is considered the dominant mode of heat transfer and the medium temperature is obtained from the energy equation. To evaluate the nongray behavior of the participating gases properly, the spectral‐line weighted‐sum‐of‐gray‐gases (SLW) model with updated correlations is used. The dependence of absorption coefficients and the weights of the SLW model on the temperature of the medium makes the inverse problem nonlinear and difficult to handle. Here, the inverse problem is formulated as an optimization problem and the Levenberg‐Marquardt method has been used to solve it. The finite volume method is exploited for the discretization of the energy equation and the spatial discretization of the radiative transfer equation (RTE). The discrete ordinates method (TN quadrature) is used for the angular discretization of RTE. Five test cases, including homogeneous and inhomogeneous media, are investigated to prove the ability of the present methodology for achieving the desired conditions.
Thermal intensification of heat transfer characteristics on the plate‐fin heat sink with piezoelectric fan
Authors: Gugulothu Santosh K. , Chamkha Ali J. 
Published: July 2019

AbstractThis study applied the computational fluid dynamic (CFD) code, ANSYS Fluent for simulating the effect a piezoelectric fan installed inside the rectangular channel by numerical simulation method for transient flow field and investigating the influence of each parameter. To remove the disorganized form of energy from the electronic components, the reversible piezoelectric effect is employed to energize the piezoelectric fan. To observe the variation of fan characteristics and to predict the convective heat transfer coefficient, CFD code ANSYS Fluent 15.0 is used. The numerical simulation parameters included are Nusselt number, number of fins (n = 12 and 14), and counter‐shift (inward and outward‐phase), and distance between the upper portion of the fan tip to the front part of the low thermal reservoir. Numerical analysis was carried out to evaluate the effect of thermal flow fields on the heat sink and piezoelectric fan employed in a flow domain. the results showed that by varying the height from channel bottom to the center of piezoelectric fan improves the performance of the piezoelectric fan, piezoelectric fan swinging in a transient phenomena and also simultaneously influences fluid flow behavior on the heat source surface, the fan vibration at counter‐phase has a better rate of heat transfer than vibration in in‐phase.
Towards Sustainable Environmental Quality: Priority Research Questions for the Australasian Region of Oceania
Authors: Gaw Sally , Harford Andrew , Pettigrove Vincent , Sevicke-Jones Graham , Manning Therese , Ataria James , Cresswell Tom , Dafforn Katherine A , Leusch Frederic DL , Moggridge Bradley , Cameron Marcus , Chapman John , Coates Gary , Colville Anne , Death Claire , Hageman Kimberly , Hassell Kathryn , Hoak Molly , Gadd Jennifer , Jolley Dianne F , Karami Ali , Kotzakoulakis Konstantinos , Lim Richard , McRae Nicole , Metzeling Leon , Mooney Thomas , Myers Jackie , Pearson Andrew , Saaristo Minna , Sharley Dave , Stuthe Julia , Sutherland Oliver , Thomas Oliver , Tremblay Louis , Wood Waitangi , Boxall Alistair BA , Rudd Murray A , Brooks Bryan W 
Published: July 2019

Abstract
Environmental challenges persist across the world, including the Australasian region of Oceania, where biodiversity hotspots and unique ecosystems such as the Great Barrier Reef are common. These systems are routinely affected by multiple stressors from anthropogenic activities, and increasingly influenced by global megatrends (e.g., the food–energy–water nexus, demographic transitions to cities) and climate change. Here we report priority research questions from the Global Horizon Scanning Project, which aimed to identify, prioritize, and advance environmental quality research needs from an Australasian perspective, within a global context. We employed a transparent and inclusive process of soliciting key questions from Australasian members of the Society of Environmental Toxicology and Chemistry. Following submission of 78 questions, 20 priority research questions were identified during an expert workshop in Nelson, New Zealand. These research questions covered a range of issues of global relevance, including research needed to more closely integrate ecotoxicology and ecology for the protection of ecosystems, increase flexibility for prioritizing chemical substances currently in commerce, understand the impacts of complex mixtures and multiple stressors, and define environmental quality and ecosystem integrity of temporary waters. Some questions have specific relevance to Australasia, particularly the uncertainties associated with using toxicity data from exotic species to protect unique indigenous species. Several related priority questions deal with the theme of how widely international ecotoxicological data and databases can be applied to regional ecosystems. Other timely questions, which focus on improving predictive chemistry and toxicology tools and techniques, will be important to answer several of the priority questions identified here. Another important question raised was how to protect local cultural and social values and maintain indigenous engagement during problem formulation and identification of ecosystem protection goals. Addressing these questions will be challenging, but doing so promises to advance environmental sustainability in Oceania and globally.
Copolymerization of carbon dioxide and propylene oxide catalyzed by two kinds of bifunctional salen‐cobalt(III) complexes bearing four quaternary ammonium salts
Authors: Du Longchao , Wang Chengze , Zhu Weiju , Zhang Jie 
Published: July 2019

AbstractTwo new bifunctional salen‐cobalt(III) complexes were synthesized, which consist of salicylaldehyde bearing four quaternary ammonium salts and two different diamines. The copolymerization results indicated that decreasing temperature is advantageous for both the complexes. Of both the diamines, the complex 9 with o‐diaminobenzene has a higher catalytic effect compared to complex 6 with 1,2‐diaminocyclohexane. The catalytic effect of complex 9 is over 3.5 times than that of complex 6 at a temperature of 30°C. The research of PCO2 on the copolymerization revealed that the first‐rank pressure was at 2 MPa for the two complexes. The highest turnover number are under conditions of T = 30°C, PCO2 = 2 MPa, and t = 24 hr. Differential scanning calorimeter curves indicated that poly(propylene carbonate) (PPC) by complex 9 has the highest Tg of 54.2°C. DTGA curves showed that there were two thermal degradation peaks, the first is for the ester bond, and the second is for the C–C bond.
MFN2 silencing promotes neural differentiation of embryonic stem cells via the Akt signaling pathway
Authors: Yi Siqi , Cui Chenghao , Huang Xiaotian , Yin Xiaohui , Li Yang , Wen Jinhua , Luan Qingxian 
Published: July 2019

AbstractMitofusin 2 (MFN2) is a regulatory protein participating in mitochondria dynamics, cell proliferation, death, differentiation, and so on. This study aims at revealing the functional role of MFN2 in the pluripotency maintenance and primitive differetiation of embryonic stem cell (ESCs). A dox inducible silencing and routine overexpressing approach was used to downregulate and upregulate MFN2 expression, respectively. We have compared the morphology, cell proliferation, and expression level of pluripotent genes in various groups. We also used directed differentiation methods to test the differentiation capacity of various groups. The Akt signaling pathway was explored by the western blot assay. MFN2 upregulation in ESCs exhibited a typical cell morphology and similar cell proliferation, but decreased pluripotent gene markers. In addition, MFN2 overexpression inhibited ESCs differentiation into the mesendoderm, while MFN2 silencing ESCs exhibited a normal cell morphology, slower cell proliferation and elevated pluripotency markers. For differentiation, MFN2 silencing ESCs exhibited enhanced three germs' differentiation ability. Moreover, the protein levels of phosphorylated Akt308 and Akt473 decreased in MFN2 silenced ESCs, and recovered in the neural differentiation process. When treated with the Akt inhibitor, the neural differentiation capacity of the MFN2 silenced ESCs can reverse to a normal level. Taken together, the data indicated that the appropriate level of MFN2 expression is essential for pluripotency and differentiation capacity in ESCs. The increased neural differentiation ability by MFN2 silencing is strongly related to the Akt signaling pathway.
Tumour‐derived transforming growth factor‐β signalling contributes to fibrosis in patients with cancer cachexia
Authors: Lima Joanna D.C.C. , Simoes Estefania , de Castro Gabriela , Morais Mychel Raony P.T. , de Matos‐Neto Emidio M. , Alves Michele J. , Pinto Nelson I. , Figueredo Raquel G. , Zorn Telma M.T. , Felipe‐Silva Aloísio S. , Tokeshi Flavio , Otoch José P. , Alcantara Paulo , Cabral Fernanda J. , Ferro Emer S. , Laviano Alessandro , Seelaender Marilia 
Published: July 2019

AbstractBackgroundCachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro‐environment contributes to systemic inflammation and increased oxidative stress as well as to fibrosis. The aim of the present study was to characterise the inflammatory circulating factors and tumour micro‐environment profile, as potentially contributing to tumour fibrosis in cachectic cancer patients.Methods74 patients (weight stable cancer n = 31; cachectic cancer n = 43) diagnosed with colorectal cancer were recruited, and tumour biopsies were collected during surgery. Multiplex assay was performed to study inflammatory cytokines and growth factors. Immunohistochemistry analysis was carried out to study extracellular matrix components.ResultsHigher protein expression of inflammatory cytokines and growth factors such as epidermal growth factor, granulocyte–macrophage colony‐stimulating factor, interferon‐α, and interleukin (IL)‐8 was observed in the tumour and serum of cachectic cancer patients in comparison with weight‐stable counterparts. Also, IL‐8 was positively correlated with weight loss in cachectic patients (P = 0.04; r = 0.627). Immunohistochemistry staining showed intense collagen deposition (P = 0.0006) and increased presence of α‐smooth muscle actin (P < 0.0001) in tumours of cachectic cancer patients, characterizing fibrosis. In addition, higher transforming growth factor (TGF)‐β1, TGF‐β2, and TGF‐β3 expression (P = 0.003, P = 0.05, and P = 0.047, respectively) was found in the tumour of cachectic patients, parallel to p38 mitogen‐activated protein kinase alteration. Hypoxia‐inducible factor‐1α mRNA content was significantly increased in the tumour of cachectic patients, when compared with weight‐stable group (P = 0.005).ConclusionsOur results demonstrate TGF‐β pathway activation in the tumour in cachexia, through the (non‐canonical) mitogen‐activated protein kinase pathway. The results show that during cachexia, intratumoural inflammatory response contributes to the onset of fibrosis. Tumour remodelling, probably by TGF‐β‐induced transdifferentiation of fibroblasts to myofibroblasts, induces unbalanced inflammatory cytokine profile, angiogenesis, and elevation of extracellular matrix components (EMC). We speculate that these changes may affect tumour aggressiveness and present consequences in peripheral organs.
Preparation of magnetic conjugated microporous polymers for highly efficient removal of dye from water
Authors: Wang Wenlong , Yu Jinfeng , Yang Xiaoxin , Yu Binglong , Cai Xiulan 
Published: July 2019

AbstractBACKGROUNDA magnetic conjugated microporous polymer (MCMP) composite was designed with bromo groups of CMP and amino groups on the surface of Fe3O4 nanoparticles that acted as promising adsorbents for wastewater treatment. Fe3O4 nanoparticles were successfully bonded on the predesigned CMP material to form the MCMP by means of a new and simple nucleophilic substitution reaction in organic media.RESULTSThe MCMP could be separated by applying an external magnetic field because of the Fe3O4 nanoparticles. It exhibited sufficient dye adsorption for methylene blue (MB) with a high sorption capability of 869.43 mg g−1 in aqueous solutions. The recovery and reusability of MCMP were >70% after six cycles of desorption and regeneration, indicating that the MCMP had excellent cycle stability. The magnetization saturation strength of MCMP was 13.5 emu g−1 which was sufficient to be magnetically separated from wastewater using artificial magnetic fields.CONCLUSIONThe MCMP possessed excellent adsorption capacity and dispersibility, and good recyclability after banded with functionalized Fe3O4 nanoparticles. The excellent properties of MCMP indicated that it could be used as an adsorbent with great application potential for quick separation of water pollutants such as dyes in wastewater treatment. © 2019 Society of Chemical Industry
Atrial peak longitudinal strain may be predictive of pancolitis in patients with ulcerative colitis
Authors: Kahyaoglu Muzaffer , Gunay Nuran , Bayam Emrah , Yilmaz Yusuf , Gecmen Cetin , Ozdil Kamil , Uyan Cihangir 
Published: July 2019

AbstractBackgroundUlcerative colitis is a chronic idiopathic inflammatory bowel disease of the colon that is characterized by a relapsing and remitting course. Previous studies have shown that arterial stiffness, carotid intima media thickness, atrial electromechanical delay, and global longitudinal strain suggested subclinical cardiovascular disorders in ulcerative colitis patients. The aims of our study was to evaluate the left atrial function of patients with ulcerative colitis by using speckle tracking echocardiography, and to assess the relationship between echocardiographic variables and the extent of the disease.MethodsWe recruited 51 outpatients with ulcerative colitis in remission phase and 52 healthy volunteers. The ulcerative colitis patients were evaluated by for the extent of the disease by endoscopy at the initial diagnosis.Results
E/Em, left atrial volume, and left atrial stiffness index were higher, and peak atrial longitudinal strain was lower in pancolitis than in non‐pancolitis patients. In the multivariate logistic regression test, peak atrial longitudinal strain and E/Em were found to be independent predictors for pancolitis.ConclusionEarly detection of myocardial abnormalities by conventional echocardiography and speckle tracking echocardiography, which is a simple and non‐invasive technique, may be useful for giving insights to the extent of the disease in ulcerative colitis patients.
In defense of proteins: Chaperones respond to freezing, anoxia, or dehydration stress in tissues of freeze tolerant wood frogs
Authors: Storey Janet M. , Storey Kenneth B. 
Published: July 2019

AbstractWood frogs (Rana sylvatica LeConte) are the major model for studies of natural freeze tolerance by ectothermic vertebrates. Multiple biochemical adaptations support winter freezing survival but, to date, the protective role of chaperone proteins has received little attention. The present study analyzes responses to freezing, anoxia or dehydration exposures and recovery from these stresses by chaperone proteins in six wood frog organs: Five heat shock proteins (Hsc70, Hsp110, Hsp60, Hsp40, and Hsp10) and two glucose‐regulated proteins (Grp78 and Grp94) were assessed. Hsc70 was upregulated in liver, muscle, heart and kidney (1.5–2.0 fold) during freezing and levels of its partner proteins also rose (Hsp110 in three tissues and Hsp40 in four tissues), these responses aligning most closely with comparable responses to anoxia rather than to dehydration. The resident chaperones of the endoplasmic reticulum (Grp78 and Grp94) also rose during freezing in liver and muscle (1.4–1.8 fold) but were suppressed in heart and skin, patterns that generally differed from responses to anoxia or dehydration. Elevated GRPs in liver may support the production and secretion of novel freeze responsive proteins. Increased levels of mitochondrial Hsp60 and Hsp10 (1.5–2.2 fold) occurred in most tissues during freezing and generally mimicked responses to anoxia. Overall, this study indicates that increased levels of chaperone proteins resident in multiple subcellular compartments contribute to stabilizing the cellular proteome during whole body freezing of wood frogs. These responses are probably derived from pre‐existing amphibian defenses for stabilizing the proteome under environmental low oxygen or dehydration stresses.
1784: The Marquis de Puységur and the psychological turn in the west
Authors: Crabtree Adam 
Published: July 2019

AbstractIn 1970 Henri Ellenberger called attention to the previously unrecognized importance of Franz Anton Mesmer's “animal magnetism” in the rise of psychodynamic psychology in the West. This article takes the next step of tracing the course of events that led to Puységur's discovery of magnetic somnambulism and describing the tumultuous social and political climate into which it was introduced in 1784. Beginning from the secret and private publication of his first Mémoires, only a few copies of which remain today, the original core of his discovery is identified and the subsequent development of its implications are examined. Puysègur was initiated into his investigations by Mesmer's system of physical healing, which bears some resemblance to the traditional healing approaches of the East. But Puységur took Mesmer's ideas in an unexpected direction. In doing so, he accomplished a turn toward the psychological that remains one of the distinguishing features of Western culture.
Machine learning in breast MRI
Authors: Reig Beatriu , Heacock Laura , Geras Krzysztof J. , Moy Linda 
Published: July 2019

Machine‐learning techniques have led to remarkable advances in data extraction and analysis of medical imaging. Applications of machine learning to breast MRI continue to expand rapidly as increasingly accurate 3D breast and lesion segmentation allows the combination of radiologist‐level interpretation (eg, BI‐RADS lexicon), data from advanced multiparametric imaging techniques, and patient‐level data such as genetic risk markers. Advances in breast MRI feature extraction have led to rapid dataset analysis, which offers promise in large pooled multiinstitutional data analysis. The object of this review is to provide an overview of machine‐learning and deep‐learning techniques for breast MRI, including supervised and unsupervised methods, anatomic breast segmentation, and lesion segmentation. Finally, it explores the role of machine learning, current limitations, and future applications to texture analysis, radiomics, and radiogenomics.Level of Evidence: 3Technical Efficacy Stage: 2J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2020;52:998–1018.
Hepatitis C virus genotype 1 infection: Prevalence of NS5A and NS5B resistance‐associated substitutions in naïve patients from Argentina
Authors: Martínez Alfredo P. , García Gabriel , Ridruejo Ezequiel , Culasso Andrés CA , Pérez Paula S. , Pereson Matías J , Neukam Karin , Flichman Diego , Di Lello Federico A. 
Published: July 2019

AbstractDirect acting antiviral (DAA) therapy against hepatitis C virus (HCV) increases sustained virologic response rates. Nevertheless, drug resistance has occasionally been associated with failure to DAA. However, the information about the prevalence of NS5A and NS5B resistance‐associated substitutions (RASs) in Argentina is very scarce. In this study, we determine the prevalence of NS5A and NS5B resistances to treatment in Argentinean DAA treatment‐naïve patients chronically infected with genotype 1 (HCV‐1). In this retrospective cross‐sectional study, 108 HCV‐1‐infected patients were studied. RASs in NS5A and NS5B were analyzed by Sanger at baseline and phylogenetic analysis was performed. NS5A and NS5B RASs were detected in 25.8% and 6.3% of the analyzed sequences, respectively. The most frequent primary RASs for NS5A were L31M (7.5%) and Y93H (3.2%) and for NS5B was L159F (3.8%). No association between the presence of RASs and the outcome of DAA treatment was found in this study. Additionally, most of the Argentinean samples were randomly distributed among sequences around the world in the phylogenetic analysis. Only one significant Argentinean cluster was observed in both regions but without any particular RASs pattern. Baseline RASs in NS5A and NS5B were frequently observed in HCV‐1‐infected patients from Buenos Aires, Argentina but not related to treatment outcome. No clusters related to RASs transmission were observed in the phylogenetic analysis. The frequency of RASs detected in this study supports the need for more molecular epidemiology studies on RASs to adjust local treatment guidelines with the incorporation of autochthonous data.
Reduced extremes of sub‐daily temperature swings during the boreal summer in the Northern Hemisphere
Authors: Zhang Wei , Villarini Gabriele , Scoccimarro Enrico 
Published: July 2019

AbstractAbrupt swings in temperature can exert negative impacts, ranging from human health to agricultural production. Here, we focus on a global assessment of the extremes in the temperature swings at sub‐daily scales using Modern‐Era Retrospective analysis for Research and Applications, Version 2 (MERRA‐2) data. Overall, the regions with extremely large swings in hourly temperature (i.e., 99th percentile) are located in desert or arid regions, and the land masses exhibit larger temperature swings than the oceans. In contrast, the first percentile of the hourly temperature swings exhibits a different spatial pattern, with the lowest values (i.e., largest negative swings) located in the Rocky Mountain, South Australia, South and North Africa and some regions in Northwestern China. We identify a significant downward/upward trend in the 99th/1st percentile of sub‐daily (i.e., hourly and 12 hr) temperature changes in the midlatitudes in the Northern Hemisphere, particularly during boreal summer. Overall, the regions with significant trends in the Northern Hemisphere are collocated with the paths of the jet streams and storm tracks. The significant downward/upward trends in the 99th/1st percentile of the sub‐daily temperature swings over the Northern Hemisphere can be explained by a weakening in the Northern Hemisphere's summer circulation, as suggested by the downward trend in the eddy kinetic energy. These results indicate that a weak/strong persistence in the circulation may lead to less/more abrupt temperature swings (i.e., increase or decrease) caused by horizontal temperature advection.