bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fracturas atípicas de fémur proximal asociadas al uso prolongado de bifosfonatos.
Authors: Neder Yamile Vanina , Fazio Alejandro , Valle Pablo , Faule Facundo , Finola Mariano 
Published: August 2018

IntroducciónLos bifosfonatos constituyen el tratamiento de primera elección de la enfermedad osteoporótica. Algunos efectos adversos ponen en duda su uso prolongado, como las fracturas atípicas de fémur proximal. Los objetivos de este estudio fueron determinar la relación entre consumo de bifosfonatos y fracturas atípicas de fémur, mostrar la incidencia en nuestra institución y el tiempo de consumo.Materiales y MétodosEstudio retrospectivo, observacional, análisis de caso-control no pareado. Se incluyeron pacientes >55 años, con fractura de fémur que ingresaron entre el 1 de enero de 2009 y el 31 de mayo de 2015. Las variables consideradas fueron: sexo, edad, tipo de fractura; uso, tipo y tiempo de consumo de bifosfonatos. Las fracturas se distribuyeron en típicas: pertrocantéricas, y cuello femoral, y atípicas: subtrocantéricas y diafisarias. Se consideraron como casos las fracturas atípicas y como controles, las pertrocantéricas.Resultados Se incluyó a 517 pacientes que cumplieron los criterios de inclusión. Cuarenta y dos fracturas eran atípicas y 236, típicas. Hubo predominio de sexo femenino (81,4% en los casos y 83% en los controles). La edad promedio fue de 76 y 80 años, respectivamente. La asociación con bifosfonatos fue del 44,2% en los casos y 15,3% en los controles (11,6% y 0,8% en las fracturas pertrocantéricas, respectivamente).ConclusionesEl alendronato se asoció significativamente con fracturas atípicas de fémur. No se halló relación con el tiempo de consumo; sin embargo, la incidencia fue más alta luego de 4.5-5 años de consumo.
Colgajo paraescapular en pérdidas postraumáticas de tejidos blandos de las extremidades. [Parascapular flap in post-traumatic soft-tissue loss at the limbs.]
Authors: Vanoli Fernando , Murillo Bernando Omar , Lobos Centeno Esteban , Gentile Luciano , Gutierrez Olivera Natalia , Allende Nores Christian Antonio 
Published: August 2018

IntroducciónEl objetivo de este artículo es comunicar los resultados obtenidos con el uso del colgajo paraescapular para cubrir defectos severos postraumáticos de tejidos blandos en las extremidades. Materiales y Métodos Estudio retrospectivo, descriptivo, de una serie de 20 pacientes a los que se les realizó un colgajo libre paraescapular para cubrir lesiones masivas combinadas postraumáticas de tejidos blandos en las extremidades, entre 2006 y 2017. La edad de los pacientes promedió 30 años (18 hombres, 2 mujeres). La localización de las lesiones fue: 10 en antebrazo y muñeca, una en la región inguinal, siete en la pierna y dos en tobillo/pie.ResultadosEl seguimiento promedió fue de 3.6 años. Se logró la cobertura exitosa en 17 casos. El tamaño de los colgajos promedió 24,8 x 10,7 cm. Seis casos presentaron lesiones vasculonerviosa que necesitaron injerto, seis se asociaron a pérdidas óseas, once requirieron injerto de piel y cuatro, reconstrucciones tendinosas. En todos los pacientes, el área donante cerró en forma primaria y sin secuelas funcionales. Dicho colgajo se combinó con el escapular en tres casos y con colgajo de dorsal ancho en tres casos. Dos colgajos fallaron y debió amputarse la extremidad lesionada; un paciente falleció por embolia masiva al séptimo día de la cirugía.ConclusionesEl colgajo paraescapular permitió salvar y reconstruir satisfactoriamente defectos masivos extensos en 17 de 20 extremidades, sin morbilidad para la zona donante del colgajo, pero su uso no está exento de complicaciones, y un abordaje multidisciplinario es necesario para disminuir esta morbilidad.
Novel 3D-printed methacrylated chitosan-laponite nanosilicate composite scaffolds enhance cell growth and biomineral formation in MC3T3 pre-osteoblasts
Authors: Cebe Tugba , Ahuja Neelam , Monte Felipe , Awad Kamal , Vyavhare Kimaya , Aswath Pranesh , Huang Jian , Brotto Marco , Varanasi Venu 
Published: August 2018

Abstract
ФОРМУВАННЯ ТЕХНОЛОГІЇ ОЧИСТКИ РОСЛИННОЇ ОЛІЇ В УМОВАХ МІНІ-ЦЕХІВ
Authors: Осадчук Петро Ігорович , Дударев Іван І. 
Published: August 2018

Створено комплекс технічних засобів, що включає обладнання і блоки пресування насіння, адсорбентної рафінації, гідратації і коагуляції, центрифугування і дезодорації, очищення і мікрофільтрації олії. Конструкції технічних засобів дозволяють компонувати окремі складові частини поблочно (модульно), враховуючи умови їх розміщення у мало контурних цехах. У технологічному процесі, за необхідності використовується ультразвуковий кавітатор для зниження кислотності олії. Сформований за цим принципом комплекс забезпечує одержання екологічно чистої рослинної олії за безвідхідною технологією, що актуальна для фермерських господарств. Олія такої якості відноситься до категорії кашерних продуктів. To obtain high-quality edible oils, these should be as much as possible cleaned from concomitant substances, mechanical impurities, phosphatides, waxes, soap and hydrophobic fractions. This process can be realized on the basis of physical methods developed by us with the help of special centrifugal devices, ceramic microfilters, hydration means for purifying phosphatidic concentrate with subsequent belting filtration of mono-dibasic unsaturated acids A complex of technical means was developed, including equipment and blocks for pressing the seed, adsorbent refinement, hydration and coagulation, centrifugation and deodorization, cleaning and microfiltration of oils. Structures of technical means allow to compose separate components of a unit (modular), taking into account the conditions of their placement in small contour workshops. In the technological process, if necessary, an ultrasonic cavitator is used to reduce the acidity of the oil. The complex formed on this principle ensures the production of ecologically pure vegetable oil in the non-waste technology and in the conditions of the farms. Oil of this quality belongs to the category of casserole products.The technological process involves pressing the seeds, then feeding to a centrifuge for purification from mechanical impurities, for removing water and lightly flowing fractions into a vacuum chamber and microfiltration and lighting in the super-cleaner unit, an ultrasonic cavitator is used to reduce the acidity of the oil. The vegetable oil retains its organoleptic qualities and the nutritional value of the product. Such an effect is achieved by the use of only the production of oils, physical and mechanical processes, without chemical treatment. The technology is implemented by a compact small-scale technical complex, executed in a modular-block type, which is easy to control.
Drug development and open access: approaches and perspectives
Authors: Debabov Dmitri V. , Debabova Maria D. 
Published: August 2018

ABSTRACT
The development of a new medicine is a process that requires enormous time and tremendous financing. It takes 10-15 years from the discovery of an active compound to the launch of its production and the start of drug marketing with the total costs of the project reaching 1.8 billion US dollars. These large time and financial costs stem from repeated testing and elimination of a large percentage of compounds over the course of screening at each stage of preclinical and clinical trials. Many investors have lost interest in financing new drug discovery projects (or pharmaceutical start-up companies) due to the high risk and extensive time required to produce a return on investments. Since all the research data are considered confidential by pharmaceutical companies and thus never shared with scientific community, different scientific groups waste significant resources repeating the same costly experiments in drug discovery. In this article, we discuss new approaches to drug discovery involving open access to the research data and alternative financing that could significantly streamline the search for new cures for human diseases.
Impact of Material Training, Instructor, Facilities, Infrastructure in Implementation of Internship Program with Participants of Courses and Job Training (Study Program Implementation Internship in Central Java)
Authors: . Jakino , . Wirawan , Supriyadi Edy 
Published: August 2018

The purpose of this research is to know the training materials, instructur/educator, facilities and infrastructure, in the implementation of the apprenticeship program of course students and training on the word of work (study implementation of internship program in central java). The methods used in this research is a method of quantitative deskriptif. Design research is depicted in the form of graphs or flow correlation studies. The population in this study are all the employees leaner apprenticeship progrem in 2016 and 2017 in central jawa of 750 people. The sampling technique used is a non probability sampling with a sampling of saturated, so the whole population was made a sample in this study. The method of collection through, the question form, interviews, observations,tests, documentation and so on. This research analyzed quantitatively through multivariate, methods of engineering Structural Equation Models (SEM) use the program smart pls 2. The results showed that the variable training materials positive effect knowledge and skills of apprentices and the wordl of work Variable characteristics knowledge and skills positive effect skills enhancement. Variable characteristics of training materials no effect to the world of work. Variable instructor/educator has no effect the world and of work but has a positive relationship direction.Variable facilities and infrastructure positive effect the internship program
A Study of Consumer Attitudes towards Mobile Advertising among the Undergraduates of University of Jaffna Srilanka
Authors: S Sivanenthira , E Ratnam , D Sabina 
Published: August 2018

Since the development of communication technology. The mobile advertisement has played a major role in the day today life. Currently around 4.9 billion people in the world own 7.19 billion mobile subscriptions, consequently as a developing country Sri Lanka the number of mobile phone use is 22.1 million. Especially youth has used the mobile devices rapidly and active with mobile advertisements. More over University undergraduates very much spend time with the mobile phones and searching the advertisements and entertainment activities via mobile phone and WAP (wireless application protocol) facilities helps to involve the UOJSL (University of Jaffna, Sri Lanka) undergraduates to more user friendly with mobile phones. In this research the deductive approach has been implemented in order to answer the research questions. Quantitative data has been collected through a questionnaire. The statements used in the questionnaire are based on previous studies and theories. The data retrieved through the questionnaire has been analysed using SPSS. The results of this study showed the UOJSL undergraduates mainly consumer based acceptance drivers and innovation based acceptance driver’s levels are highly determining on attitudes towards mobile advertising. Furthermore, it was found that the more positive the attitude toward advertising in general is, and the more the consumer likes searching for product information. The main purpose of this research was to find out what the attitudes of the UOJSL undergraduates are toward mobile advertising. The statistical results showed a positive attitude toward mobile advertising.
As necessidades da pesquisa experimental em psicolingüística no Brasil
Authors: Scliar-Cabral Leonor 
Published: August 2018

This paper takes a historical perspective on the state of the art of experimental psycholinguistics in Brazil and attempts to make a diagnosis of the resources needed, both material and human, for the advancement of the field in this country. It is suggested that a comprehensive database on existing research centers and their scientific production be constructed in order to stimulate peer contact and debate. An recommendation is also made for curricula to be designed in such a way graduates in Psychology get the proper linguistics training and graduates in Linguistics get the proper training in experimental design and statistics.
Memória de trabalho e produção oral da linguagem
Authors: Lima Paula Lenz Costa , Françozo Edson 
Published: August 2018

In this paper, we examine the use of silent pauses made by high and low working memory span individuals, during the reading span test (the Brazilian Portuguese version), aiming at verifying possible strategies used by the subjects in order to accommodate the transient computational and storage demands that occur in the task. Our results are congruent with the idea that language production quality is also influenced by the subjects´ working memory capacity: high span subjects produced more sentences without pause, made shorter pauses, and therefore spent less time reading the test sentences than low span subjects.
Inaccuracies in the 2020 Census Enumeration Could Create a Misalignment Between States’ Needs
Authors: Strane Douglas , Griffis Heather M. 
Published: August 2018

As the most accurate reflection of the United States population, the US decennial census is vital to health policymakers and others at all levels of government. Competing priorities related to cost containment and the introduction of new reforms raise concerns about the resources available to the US Census Bureau to conduct an accurate population enumeration in 2020. We examined the state of the Census Bureau’s preparations for the 2020 Census and how inaccuracies in the coming census enumeration could influence public health and health equity in the coming decade. The results of the 2020 Census will be used to allocate trillions of dollars in federal funding to states, including support for programs vital to public health such as Medicaid and the Special Supplemental Nutrition Program for Women, Infants, and Children. Inaccuracies in the census enumeration could create a misalignment between states’ needs and allocation of federal resources. Also, a census miscount of the population could create challenges for public health surveillance and research activities that inform public health policies and interventions.
Effects of Low‐Grade Weirs on Soil Microbial Communities in Agricultural Drainage Ditches
Authors: Baker Beth H. , Brooks John P. , Deng Dewayne D. , Smith Renotta K. , Kröger Robert , Prince Czarnecki Joby M. 
Published: August 2018

Agricultural fertilizer application throughout the Mississippi River basin has been identified as a major source of N pollution to the Gulf of Mexico. Using best management practices, such as low‐grade weirs, has been identified as a potential solution to mitigate nutrient loads in agricultural runoff. This study assessed impacts of weir implementation in four agricultural drainage ditches (three with weirs and one control site) in the Mississippi Delta. Soil samples collected from field locations in spring 2013 were analyzed for denitrifier abundance using genes (16s ribosomal RNA [rRNA] genes,nosZ,nirS, andnirK) via quantitative polymerase chain reaction (qPCR), microbial community profiles via terminal‐restriction fragment length polymorphism (T‐RFLP) of 16s rRNA genes, soil parameters (C, N, and moisture), and vegetation presence at sample locations. Gene quantification was successful, except fornirK, which was found below detection limits (5000 gene copies g−1soil). Distance from weirs was negatively correlated with 16S rRNA genes and soil moisture, and soil moisture was positively correlated with 16s rRNA andnirS gene abundance. Results of empirical Bayesian kriging did not exhibit obvious patterns of microbial diversity in relation to weir proximity. Preliminary assessment of seasonal trends showed genes 16s rRNA andnirS, soil N, and mean T‐RF values to be greater in fall than in spring. Results highlight that weirs had no direct impact on microbial diversity or denitrification functional gene abundance. Correlations between microbial measures and environmental parameters suggest that adequate management of N runoff from agricultural landscapes will require ecological engineering beyond weirs to optimize N mitigation.Core IdeasMicrobial communities were not different between ditches with and without weirs.Distance from weirs was negatively correlated with 16s rRNA genes and soil moisture.Soil moisture was positively correlated with 16s rRNA andnirSfunctional genes.Preliminary data showed seasonal differences in microbial diversity.
Evaluation of Gridded Meteorological Data for Calculating Water Balance Cover Storage Requirements
Authors: Breitmeyer Ronald J. , Stewart Mary Kate , Huntington Justin L. 
Published: August 2018

Core Ideas
Required storage is a critical design parameter for water balance soil covers.
Gridded meteorological data and station data result in consistent required storage.
Gridded data result in higher required storage for sites with significant snowfall.
Modeled cover system performance based on station and gridded data is consistent.
Gridded data tend to result in conservative or higher estimates of required storage.
Water balance cover (WBC) systems are attractive for waste management facilities in arid to semiarid environments because they are a lower cost alternative to conventional geotechnical soil or composite barrier‐style covers. The required storage (Sr) for a WBC is dependent on climatic conditions, with the most influence from the seasonal balance of precipitation (P) and potential evapotranspiration (PET). Gridded meteorological datasets provide long‐term, continuous, and accessible sources of P and PET for Sr estimation. Six sites in Nevada were analyzed for the agreement among P, PET, and Sr calculated from station and gridded meteorological data (gridMET). Two sites each at elevations of 0 to 1000 m asl, 1000 to 1500 m asl, and 1500 to 2000 m asl were considered during a 21‐yr period. The gridMET and station‐based P and Sr were generally not significantly different for sites between 0 and 1500 m asl. For sites above 1500 m asl, the differences in P were significant. For the sites analyzed in this study, gridMET typically resulted in equivalent or more conservative estimates of WBC Sr. Percolation rates from hypothetical WBCs were also simulated in the flow model HYDRUS to evaluate WBC performance when using station‐based or gridMET‐based atmospheric model boundary conditions. Simulations indicate that percolation rates are higher when gridMET atmospheric data are used vs. station‐based data for five out of the six sites. This suggests that gridMET‐based model boundary conditions provide a degree of conservatism in calculating WBC Sr. This trend was not ubiquitous for all sites (one out of six did not follow), indicating that further study is required before applying these findings generally.
Caffeic Acid Phenethyl Ester Effects: In Silico Study of its Osteoimmunological Mechanisms
Authors: Zhao Yuhao , Pang Xiaokun , Nepal Akriti , Jiang Xincan , Xu Xiaoxin , Zhao Dongbin , Murtaza Ghulam , Ma Yanxu 
Published: August 2018

Background:
Biological system complexity impedes the drug target identification by
biological experiments. Thus drugs, rather than acting on target site only, can interact with the entire
biological system. Study of this phenomenon, known as network pharmacology, provides
grounds for biological target identification of new drugs or acts as a foundation for the discovery of
new targets of present drugs. No publication is available on the interaction network of CAPE.

Aim:
This study was aimed at the investigation of the candidate targets and possible interactions of
caffeic acid phenethyl ester (CAPE) involved in its osteoimmunological effects.

Methods:
This study encompasses the investigation of candidate targets and possible interactions of
CAPE by analyzing through PASS Prediction and constructing a biological network of CAPE.

Results:
In response to input (CAPE), PASS Prediction generated a network of 1723 targets. While
selecting the probability to be active (Pa) value greater than 0.7 brought forth only 27 targets for
CAPE. Most of these targets predicted the therapeutic role of CAPE as an osteoimmunological
agent. Apart from this, this network pharmacology also identified 10 potential anti-cancer targets
for CAPE, out of which 7 targets have been used efficiently in developing potent osteoimmunological
drugs.

Conclusion:
This study provides scientific prediction of the mechanisms involved in osteoimmunological
effects of CAPE, presenting its promising use in the development of a natural therapeutic
agent for the pharmaceutical industry. CAPE targets identified by web-based online databases and
network pharmacology need additional in silico assessment such as docking and MD simulation
studies and experimental verification to authenticate these results.
Cephalosporin Conjugated Sulfonamides: Synthesis, Characterization and Anticancer Activities
Authors: Nadeem Rana Asif , Abdul Qadir Muhammad , Ahmed Mahmood , Sajid Imran 
Published: August 2018

Background:
In the present study, eight new cephalosporin conjugated sulfonamides
were synthesized to investigate the anticancer activity.

Methods:
All the compounds were characterized on the basis of FTIR, 1HNMR, MS and elemental
analysis (CHN). The new compounds were evaluated against the Vero and Hep G2 cancer cell lines
for their anticancer activities. Cytotoxicity of all the compounds was determined against brine
shrimp at 20 μg concentration.

Results and Conclusion:
The results revealed that ceftriaxone conjugated sulfonamide was the
most potent and showed cytotoxicity (86.4 %) comparable to the standard reference drug actinomycin
D (90.0 %). The compounds with lower cLogP value showed more antiproliferative effect due
to their higher cell permeability. Ceftriaxone conjugated with 4-acetamido benzene sulfonyl was the
most active compound against both cell lines with IC50 3.95 μM (Vero) and 5.11 μM (Hep G2) values
whereas its activity was comparable with 5-fluorouracil used as reference drug (IC50 = 2.84 μM).