bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Law and Economics Perspective on Judicial Risk Regulation
Authors: VAN ZEBEN Josephine 
Published: March 2018

AbstractThis special issue provides several perspectives on the potential and limits of judicial risk regulation as a mechanism to redress actual and perceived regulatory failures. Central to this inquiry is the legitimacy of the court system to act as a risk regulator, specifically as compared to governmental actors. This article focuses on the question of institutional competency of juridical risk regulators from a law and economics (“L&E”) perspective. L&E scholarship will be used to help to understand the relative strengths and weaknesses of courts as risk regulators and helps us decide when courts may act as substitute risk regulators and when they are better positioned as complements.
Pigs, African Swine Fever and the Principle of Regionalisation: Comments on the Appellate Body Report in the Russia – Pigs Dispute
Authors: ARCURI Alessandra , GRUSZCZYNSKI Lukasz 
Published: March 2018

AbstractThis commentary examines the recent Appellate Body Report in Russia – Pigs. This case is salient because it offers further clarification of the principle of regionalisation in the context of WTO law. By reading the different terms of Article 6 of the SPS Agreement in a holistic way, the Appellate Body has offered an interpretation of the legal text that arguably strengthens the principle.
Emergency! But What about Legal Protection in the EU?
Authors: BINDER Tom , KARAGIANNI Argyro , SCHOLTEN Miroslava 
Published: March 2018

AbstractThe EU institutions and agencies have become increasingly involved in enforcing EU law directly vis-à-vis private actors. A number of such EU entities have also acquired the so-called emergency powers, which allow interference with the legal position of a private party. Given the lack of research in this area, the question that this article addresses is whether relevant safeguards have been introduced to ensure the rule of law in such situations to prevent the abuse of executive discretion by public authorities. What are the relevant safeguards in the emergency in the EU in the first place? Having analysed relevant EU legislation and case law, the article offers a complete overview of all the existing EU entities with the emergency powers and shows a great diversity in the extent to which the EU legislator has regulated procedural safeguards in relevant law. The article discusses what safeguards need to be ensured in an emergency and argues for clarity of legislative frameworks in this respect.
Estimating Greenland surface melt is hampered by melt induced dampening of temperature variability
Authors: KREBS-KANZOW UTA , GIERZ PAUL , LOHMANN GERRIT 
Published: March 2018

ABSTRACTThe positive degree-day (PDD) model provides a particularly simple approach to estimate surface melt from land ice based solely on air temperature. Here, we use a climate and snow pack simulation of the Greenland ice sheet (Modèle Atmosphérique Régional, MAR) as a reference, to analyze this scheme in three realizations that incorporate the sub-monthly temperature variability differently: (i) by local values, (ii) by local values that systematically overestimate the dampened variability associated with intense melting or (iii) by one constant value. Local calibrations reveal that incorporating local temperature variability, particularly resolving the dampened variability of melt areas, renders model parameters more temperature-dependent. This indicates that the negative feedback between surface melt and temperature variability introduces a non-linearity into the temperature – melt relation. To assess the skill of the individual realizations, we hindcast melt rates from MAR temperatures for each realization. For this purpose, we globally calibrate Greenland-wide, constant parameters. Realization (i) exhibits shortcomings in the spatial representation of surface melt unless temperature-dependent instead of constant parameters are calibrated. The other realizations perform comparatively well with constant parametrizations. The skill of the PDD model primarily depends, however, on the consistent calibration rather than on the specific representation of variability.
DNA barcoding mosquitoes: advice for potential prospectors
Authors: BEEBE NIGEL W. 
Published: March 2018

SUMMARYMosquitoes’ importance as vectors of pathogens that drive disease underscores the importance of precise and comparable methods of taxa identification among their species. While several molecular targets have been used to study mosquitoes since the initiation of PCR in the 1980s, its application to mosquito identification took off in the early 1990s. This review follows the research's recent journey into the use of mitochondrial DNA (mtDNA) cytochrome oxidase 1 (COI or COX1) as a DNA barcode target for mosquito species identification – a target whose utility for discriminating mosquitoes is now escalating. The pros and cons of using a mitochondrial genome target are discussed with a broad sweep of the mosquito literature suggesting that nuclear introgressions of mtDNA sequences appear to be uncommon and that the COI works well for distantly related taxa and shows encouraging utility in discriminating more closely related species such as cryptic/sibling species groups. However, the utility of COI in discriminating some closely related groups can be problematic and investigators are advised to proceed with caution as problems with incomplete lineage sorting and introgression events can result in indistinguishable COI sequences appearing in reproductively independent populations. In these – if not all – cases, it is advisable to run a nuclear marker alongside the mtDNA and thus the utility of the ribosomal DNA – and in particular the internal transcribed spacer 2 – is also briefly discussed as a useful counterpoint to the COI.
Risk of dementia associated with psychotic disorders in later life: the health in men study (HIMS)
Authors: Almeida Osvaldo P. , Ford Andrew H. , Hankey Graeme J. , Yeap Bu B. , Golledge Jonathan , Flicker Leon 
Published: March 2018

AbstractBackgroundRecent research has identified several potentially modifiable risk factors for dementia, including mental disorders. Psychotic disorders, such as schizophrenia and delusional disorder, have also been associated with increased risk of cognitive impairment and dementia, but currently available data difficult to generalise because of bias and confounding. We designed the present study to investigate if the presence of a psychotic disorder increased the risk of incident dementia in later life.MethodsProspective cohort study of a community-representative sample of 37 770 men aged 65–85 years who were free of dementia at study entry. They were followed for up to 17.7 years using electronic health records. Clinical diagnoses followed the International Classification of Diseases guidelines. As psychotic disorders increase mortality, we considered death a competing risk.ResultsA total of 8068 (21.4%) men developed dementia and 23 999 (63.5%) died during follow up. The sub-hazard ratio of dementia associated with a psychotic disorder was 2.67 (95% CI 2.30–3.09), after statistical adjustments for age and prevalent cardiovascular, respiratory, gastrointestinal and renal diseases, cancer, as well as hearing loss, depressive and bipolar disorders, and alcohol use disorder. The association between psychotic disorder and dementia risk varied slightly according to the duration of the psychotic disorder (highest for those with the shortest illness duration), but not the age of onset. No information about the use of antipsychotics was available.ConclusionOlder men with a psychotic disorder have nearly three times greater risk of developing dementia than those without psychosis. The pathways linking psychotic disorders to dementia remain unclear but may involve mechanisms other than those associated with Alzheimer's disease and other common dementia syndromes.
Timing and predictors of severe rotavirus gastroenteritis among unvaccinated infants in low- and middle-income countries
Authors: Gruber J. F. , Becker-Dreps S. , Hudgens M. G. , Brookhart M. A. , Thomas J. C. , Jonsson Funk M. 
Published: March 2018

AbstractDelays in rotavirus vaccine schedule could improve performance in low- and middle-income countries (LMICs). However, delaying the first dose could be detrimental if infants experience severe rotavirus gastroenteritis (RVGE) early in life. Our objective was to describe the timing and predictors of severe RVGE in unvaccinated children in LMICs. We analysed the placebo arms from two clinical trials (cohort 1: NCT00241644; cohort 2: NCT00362648). We estimated the rate, cumulative incidence (per 1000 infants) and age distribution of severe RVGE episodes. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals (CI) for the association between baseline factors and severe RVGE. Cumulative incidence at 6 months of age was 23/1000 (95% CI 15–30) in cohort 1 and 6/1000 (95% CI 3–8) in cohort 2. Early antibiotic use (compared with no use) was associated with 2.03 (95% CI 1.18–3.48) and 1.41 (95% CI 0.80–2.51) times the rate of severe RVGE in cohorts 1 and 2, respectively. The cumulative incidence of severe RVGE was low at 6 months of age, suggesting that a 4-week delay in the vaccination schedule may not result in a large number of severe RVGE episodes prior to vaccine receipt.
Effect of the physical activity program on the treatment of resistant hypertension in primary care
Authors: Kruk Piotr J. , Nowicki Michał 
Published: March 2018

AbstractBackgroundRegular physical activity is widely recommended for patients with arterial hypertension as an essential component of lifestyle modification. Much less is known about the impact of physical exercise on the management of treatment of resistant hypertension (RH). The aim was to assess the effect of physical activity program intensified by mobile phone text reminders on blood pressure control in subjects with RH managed in the primary care.MethodsIn total, 53 patients with primary hypertension were qualified, including 27 who met the criteria for RH and 26 with well-controlled hypertension (WCH). Ambulatory 24-h blood pressure was monitored and body composition evaluated with bioimpedance and habitual physical activity profile was determined continuously over 72 h with accelerometer. All measurements were performed at baseline and after three and six months. The patients were asked to modify their lifestyle according to American Heart Association Guidelines that included regular aerobic physical activity tailored to individual needs.FindingsPhysical activity in RH increased significantly after six months compared with control subjects (P=0.001). Office systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the RH group decreased significantly after three months but after six months only office DBP remained significantly lower. After three months 24-h SBP decreased by 3.1±11 mmHg (P=0.08) and DBP by 2.0±6 mmHg (P=0.17) in RH, whereas in WCH respective changes were +1.2±10 and −0.3±6 mmHg. After six months 24-h BP changes were similar.ConclusionIndividualized structured physical activity program increases physical activity in the treatment of resistant hypertensives in primary care but the effect on 24-h blood pressure is only transient.
Low-current cathode spatial harmonic magnetrons: analysis and realization based on metamaterial loaded slow wave structures
Authors: Esfahani Nasrin Nasr 
Published: March 2018

AbstractThis paper provides an overview of theory, design, simulation, and fabrication of novel spatial harmonic magnetrons (SHMs). An approximate analysis which provides the guidelines for the design and predicts the important characteristics of these devices will be presented. This analysis shows that the metamaterial loaded SHMs can start generating power with very small cathode current densities which is very important for designing THz sources based on SHMs. A design example with the operation frequency of 43 GHz together with the design procedure, PIC simulations, and measurement results will be examined.
The developing gut microbiota and its consequences for health
Authors: Butel M.-J. , Waligora-Dupriet A.-J. , Wydau-Dematteis S. 
Published: March 2018

AbstractThe developmental origin of health and disease highlights the importance of the period of the first 1000 days (from the conception to the 2 years of life). The process of the gut microbiota establishment is included in this time window. Various perinatal determinants, such as cesarean section delivery, type of feeding, antibiotics treatment, gestational age or environment, can affect the pattern of bacterial colonization and result in dysbiosis. The alteration of the early bacterial gut pattern can persist over several months and may have long-lasting functional effects with an impact on disease risk later in life. As for example, early gut dysbiosis has been involved in allergic diseases and obesity occurrence. Besides, while it was thought that the fetus developed under sterile conditions, recent data suggested the presence of a microbiotain utero, particularly in the placenta. Even if the origin of this microbiota and its eventual transfer to the infant are nowadays unknown, this placental microbiota could trigger immune responses in the fetus and would program the infant’s immune development during fetal life, earlier than previously considered. Moreover, several studies demonstrated a link between the composition of placental microbiota and some pathological conditions of the pregnancy. All these data show the evidence of relationships between the neonatal gut establishment and future health outcomes. Hence, the use of pre- and/or probiotics to prevent or repair any early dysbiosis is increasingly attractive to avoid long-term health consequences.
Global cybersecurity governance: A constitutionalist analysis
Authors: PERNICE INGOLF 
Published: March 2018

Abstract:With the progressive digitisation and use, in particular, of the internet of things and artificial intelligence by industries, commerce, financial services, science and education, the public administration, health services as well as individuals, our society and daily life gets more and more dependent on the security of the net: cybersecurity. The new risks are self-made, a threat to almost everybody and new in kind. And they have a global dimension. For the difficulty of attribution of cyber attacks traditional concepts of deterrence and defence are not a solution. Given the new conditions of the ‘digital constellation’ this article aims at exploring instruments and methods of cybersecurity governance in a broad sense, learning from internet governance and taking a constitutional perspective. It is based upon shared responsibility, resilience and citizens’ participation in the making and future application of an inclusive global rule-making system. Multi-stakeholder mechanisms are combined with deliberative processes, standardisation and legislative action. In accordance with the principles of global constitutionalism this new framework of global rule generation would emerge as a common democratic instrument of people to meet common challenges in addition and complementary to action for cybersecurity at the local, regional, national and supranational levels.
Suppression of Glyphosate-resistant Canada Fleabane (Conyza canadensis) in Corn with Cover Crops Seeded after Wheat Harvest the Previous Year
Authors: Cholette Taïga B. , Soltani Nader , Hooker David C. , Robinson Darren E. , Sikkema Peter H. 
Published: March 2018

AbstractGlyphosate-resistant (GR) and multiple herbicide–resistant (groups 2 and 9) Canada fleabane have been confirmed in 30 and 23 counties in Ontario, respectively. The widespread incidence of herbicide-resistant Canada fleabane highlights the importance of developing integrated weed management strategies. One strategy is to suppress Canada fleabane using cover crops. Seventeen different cover crop monocultures or polycultures were seeded after winter wheat harvest in late summer to determine GR Canada fleabane suppression in corn grown the following growing season. All cover crop treatments seeded after wheat harvest suppressed GR Canada fleabane in corn the following year. At 4 wk after cover crop emergence (WAE), estimated cover crop ground cover ranged from 31% to 68%, a density of 124 to 638 plants m–2, and a range of biomass from 29 to 109 g m–2, depending on cover crop species. All of the cover crop treatments suppressed GR Canada fleabane in corn grown the following growing season from May to September compared to the no cover crop control. Among treatments evaluated, annual ryegrass (ARG), crimson clover (CC)/ARG, oilseed radish (OSR)/CC/ARG, and OSR/CC/cereal rye (CR) were the best treatments for the suppression of GR Canada fleabane in corn. ARG alone or in combination with CC provided the most consistent GR Canada fleabane suppression, density reduction, and biomass reduction in corn. Grain corn yields were not affected by the use of the cover crops evaluated for Canada fleabane suppression.
Methane stimulates massive nitrogen loss from freshwater reservoirs in India
Authors: Naqvi S. Wajih A. , Lam Phyllis , Narvenkar Gayatree , Sarkar Amit , Naik Hema , Pratihary Anil , Shenoy Damodar M. , Gauns Mangesh , Kurian Siby , Damare Samir , Duret Manon , Lavik Gaute , Kuypers Marcel M. M. 
Published: March 2018

AbstractThe fate of the enormous amount of reactive nitrogen released to the environment by human activities in India is unknown. Here we show occurrence of seasonal stratification and generally low concentrations of dissolved inorganic combined nitrogen, and high molecular nitrogen (N2) to argon ratio, thus suggesting seasonal loss to N2 in anoxic hypolimnia of several dam-reservoirs. However, 15N-experiments yielded low rates of denitrification, anaerobic ammonium oxidation and dissimilatory nitrate reduction to ammonium—except in the presence of methane (CH4) that caused ~12-fold increase in denitrification. While nitrite-dependent anaerobic methanotrophs belonging to the NC10 phylum were present, previously considered aerobic methanotrophs were far more abundant (up to 13.9%) in anoxic hypolimnion. Methane accumulation in anoxic freshwater systems seems to facilitate rapid loss of reactive nitrogen, with generally low production of nitrous oxide (N2O), through widespread coupling between methanotrophy and denitrification, potentially mitigating eutrophication and emissions of CH4 and N2O to the atmosphere.
Super lithium-rich K giant with low 12C to 13C ratio
Authors: Zhou Y. T. , Shi J. R. , Yan H. L. , Gao Q. , Zhang J. B. , Zhao G. , Pan K. , Kumar Y. B. 
Published: March 2018

Context. The lithium abundances in a few percent of giants exceed the value predicted by the standard stellar evolution models, and the mechanisms of Li enhancement are still under debate. The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) survey has obtained over six million spectra in the past five years, and thus provides a great opportunity to search these rare objects and to more clearly understand the mechanisms of Li enhancement.
Aims. The aim of this work is to accurately measure the Li abundance and investigate the possible mechanisms of Li enrichment for a newly found super Li-rich giant, TYC 3251-581-1, located near the luminosity function bump with a low carbon isotopic ratio.
Methods. Based on the high-resolution spectrum we obtained the stellar parameters (Teff, logg, [Fe/H]), and determined the elemental abundances of Li, C, N, α, Fe-peak, r-process, s-process elements, and the projected rotational velocity. For a better understanding of the effect of mixing processes, we also derived the 12C to 13C ratio, and constrained the evolutionary status of TYC 3251-581-1 based on the BaSTI stellar isochrones.
Results. The super Li-rich giant TYC 3251-581-1 has A(Li) = 3.51, the average abundance of two lithium lines at λ = 6708 Å and 6104 Å based on the non-local thermodynamic equilibrium analysis. The atmospheric parameters show that our target locates on the luminosity function bump. The low carbon isotopic ratio (12C∕13C = 9.0), a slow rotational velocity vsini = 2.2 km s−1, and no sign of IR excess suggest that additional mixing after first dredge up (FDU) should occur to bring internal synthesized Li to the surface. The low carbon ([C∕Fe] ~−0.34) and enhanced nitrogen ([N∕Fe] ~ 0.33) are also consistent with the sign of mixing.
Conclusions. Given the evolutionary stage of TYC 3251-581-1 with the relatively low 12C∕13C, the internal production which replenishes Li in the outer layer is the most likely origin of Li enhancement for this star.
Upper-Extremity Functional Performance Tests: Reference Values for Overhead Athletes
Authors: Borms Dorien , Cools Ann 
Published: March 2018

AbstractThis study aimed to provide an age, gender and sport-based normative database for three functional shoulder tests: Y Balance Test – Upper Quarter (YBT-UQ), Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST), and Seated Medicine Ball Throw (SMBT). A second aim was to discuss gender, age and sports differences. Finally, correlation between tests was evaluated. Overhead athletes (106 male, 100 female) between 18 and 50 years old and from three different sports (volleyball, tennis, handball) performed all functional tests. A linear mixed or regression model was applied to determine significant differences in test scores between gender, age and sports. Pearson correlation coefficients were analyzed to determine the relationship between tests. Normative values were established and divided by gender, sports and age. Results showed significant gender and age differences for all tests. For YBT-UQ, also significant side and sports differences were recorded. CKCUEST is moderately correlated with SMBT and YBT-UQ. Weak correlation was found between SMBT and YBT-UQ. In conclusion, this study provides normative data for YBT-UQ, CKCUEST and SMBT, which is clinically relevant for functionally screening overhead athletes and benchmark their performance to others from the same gender, age and sports. A combination of included tests is recommended.
Exercise Training at Maximal Fat Oxidation Intensity for Older Women with Type 2 Diabetes
Authors: Tan Sijie , Du Ping , Zhao Wanting , Pang Jiaqi , Wang Jianxiong 
Published: March 2018

AbstractThe purpose of this study was to investigate the pleiotropic effects of 12 weeks of supervised exercise training at maximal fat oxidation (FATmax) intensity on body composition, lipid profile, glycemic control, insulin sensitivity and serum adipokine levels in older women with type 2 diabetes. Thirty-one women with type 2 diabetes, aged 60 to 69 years, were randomly allocated into exercise and control groups. Body composition, lipid profile, blood glucose, insulin resistance and serum leptin and adiponectin concentrations were measured before and after the intervention. Exercise group (n=16) walked at individualized FATmax intensities for 1 h/day for 3 days/week over 12 weeks. No dietary intervention was introduced during the experimental period. Maximal fat oxidation rate was 0.37±0.10 g/min, and occurred at 37.3±7.3% of the estimated VO2max. Within the exercise group, significant improvements were observed for most of the measured variables compared to non-exercising controls; in particular, the FATmax program reduced body fat% (p<0.001), visceral fat% (p<0.001), and insulin resistance (p<0.001). There was no significant change in daily energy intake for all participants during the intervention period. These results suggest that individualized FATmax training is an effective exercise training intensity for managing type 2 diabetes in older women.