bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Electronic Health Record Data Extraction and Curation Using ExtractEHR
Authors: Miller Tamara P. , Getz Kelly D. , Krause Edward , Jo Yun Gun , Charapala Sandhya , Gramatges M. Monica , Rabin Karen , Scheurer Michael E. , Wilkes Jennifer J. , Fisher Brian T. , Aplenc Richard 
Published: November 2024

PURPOSE
Although the potential transformative effect of electronic health record (EHR) data on clinical research in adult patient populations has been very extensively discussed, the effect on pediatric oncology research has been limited. Multiple factors contribute to this more limited effect, including the paucity of pediatric cancer cases in commercial EHR-derived cancer data sets and phenotypic case identification challenges in pediatric federated EHR data.

METHODS
The ExtractEHR software package was initially developed as a tool to improve clinical trial adverse event reporting but has expanded its use cases to include the development of multisite EHR data sets and the support of cancer cohorts. ExtractEHR enables customized, automated data extraction from the EHR that, when implemented across multiple hospitals, can create pediatric cancer EHR data sets to address a very wide range of research questions in pediatric oncology. After ExtractEHR data acquisition, EHR data can be cleaned and graded using CleanEHR and GradeEHR, companion software packages.

RESULTS
ExtractEHR has been installed at four leading pediatric institutions: Children's Healthcare of Atlanta, Children's Hospital of Philadelphia, Texas Children's Hospital, and Seattle Children's Hospital.

CONCLUSION
ExtractEHR has supported multiple use cases, including five clinical epidemiology studies, multicenter clinical trials, and cancer cohort assembly. Work is ongoing to develop Fast Health care Interoperability Resources ExtractEHR and implement other sustainability and scalability enhancements.
Recommendation for Clarifying FDA Policy in Evaluating “Sameness” of Higher Order Structure for Generic Peptide Therapeutics
Authors: Rogers-Crovak Jessica A. , Delaney Edward J. , Detlefsen David J. 
Published: November 2024

Abstract
Recognizing the approach of a dramatic expansion of peptide therapeutics reaching the marketplace in recent years, led by GLP-1 receptor agonists such as semaglutide and liraglutide, the Center for Drug Evaluation and Research (CDER) branch of the US Food and Drug Administration (FDA) issued a final guidance in 2021 that was intended to assist generic drug producers in meeting Abbreviated New Drug Application (ANDA) obligations to establish “sameness” of their active peptide drug relative to that produced by innovator companies. Research and a published report by FDA scientists on best practices followed, which promulgated the use of nuclear magnetic resonance (NMR) and principal component analysis (PCA) and established a quantitative standard by which “sameness” of higher order structure for the applicant’s peptide drug could be judged. A key requirement is that drug product samples be analyzed directly and non-invasively, a condition which in practice restricts sample modification to the addition of a small amount of deuterium oxide to allow signal lock and spectral data alignment (as required for NMR analysis). In the study described herein, data are presented to illustrate that 1) relatively small differences in sample pH can cause significant shifting of certain proton resonances, 2) that such resonance shifting is readily reversible and due to the degree of protonation of specific amino acid residues (rather than reflecting differences in higher order structure), and 3) that small differences in pH variability between sample cohorts can frequently cause failure to meet the quantitative benchmark established by the agency. Methodology is presented by which drug sample pHs can be aligned with minimal impact, and a recommendation is made that minor sample pH adjustments be allowed in assessing “sameness” of peptide drug higher order structure.

Graphical Abstract
Taking a Book for a Walk: A Conversation with Dayanita Singh
Authors: Boetker-Smith Daniel 
Published: November 2024

Abstract
In this extensive interview conducted over a number of sessions, offset artist, bookmaker, and photographer Dayanita Singh talks through her career with Daniel Boetker-Smith. They discuss the generation of some of Singh's most highly regarded books, her education, and her professional relationships with Walter Keller (Scalo) and Gerhard Steidl (Steidl). The conversation delves into her bookmaking philosophy and how this unique approach has crossed over into her exhibition practices.
The role of mobile applications and online platforms in the rehabilitation process of patients with coronary heart disease: a literature review
Authors: Bielecka Larysa , Bielecka Klaudia 
Published: November 2024

IntroductionNowadays, diseases of the circulatory system, such as coronary heart disease, are among the leading causes of death worldwide. Cardiac rehabilitation, a complex, interdisciplinary intervention, aims to improve cardiovascular function, enhance quality of life, and reduce mortality risk. In the era of mobile technology development, mobile applications and online platforms supporting cardiac rehabilitation are gaining increasing importance.

Aim of the study
The aim of this study is to review the literature on the effectiveness of digital tools as support mechanisms in the rehabilitation of patients with coronary heart disease, and to compare their effectiveness with traditional medical care.

Materials and MethodsA review of randomized clinical trials (RCTs) published in 2024 regarding the use of mobile and online applications in cardiac rehabilitation was conducted. Five studies meeting specific selection criteria were identified.

Results
Research shows that mobile applications and online platforms effectively support the rehabilitation of patients with coronary artery disease, achieving results comparable to or better than traditional care. Programs such as RehaPlus+ and mHealth improve physical activity, mental resilience, quality of life, and reduce stress and anxiety. Users of applications such as eMOTIVA and MCARE achieve better results in terms of diet, physical activity, and general well-being. These interventions also promote regular communication with the therapist, which supports the individualization of rehabilitation.

Conclusions
Rehabilitation of patients with coronary heart disease using mobile applications or online platforms is equally effective as, or more effective than, standard medical care.
Dizziness, light-headedness or a clot-in-transit: obtaining a history and physical exam is both a science and an art
Authors: Hoskote Abhinav , Sudadi Shreya , Dembo Brent , Consolini Michelle , Kashyap Rahul 
Published: November 2024

Introduction: Venous thromboembolism (VTE) rarely presents with dizziness as the primary complaint, which can delay diagnosis. We report a rare case of dizziness as the chief complaint for a clot-in-transit and extensive bilateral pulmonary emboli. Case description: A 70-year-old woman presented to the emergency room (ER) with dizziness and a fall, without reporting loss of consciousness. Her symptoms included positional dizziness, tinnitus and visual darkness, alongside prior exertional fatigue and dull chest pressure. Despite a history of left leg oedema and inconsistent use of medications for hypertension and diabetes, initial examinations suggested vestibular neuritis and decompensated heart failure, confirmed by echocardiogram findings and response to prednisone. While hospitalised, she experienced pre-syncope after showering, initially deemed vasovagal. However, exertional hypotension led to further investigation, revealing right heart strain. Ultrasound identified a left popliteal deep vein thrombosis, and a computed tomography (CT) angiogram confirmed extensive bilateral pulmonary emboli with right heart strain. Cardiology discovered large, mobile thrombi in transit in the heart, necessitating an urgent mechanical thrombectomy. Following treatment, her pulmonary pressure improved, and she was discharged on anticoagulation medicine. One month later, an echocardiogram showed normalised heart function. Conclusion: This case highlights the importance of differentiating dizziness from pre-syncope, as exertional pre-syncope can indicate an obstructive physiology such as VTE. Cognitive bias can obscure diagnosis in atypical presentations. A pulmonary embolism response team could improve management of these cases, where prompt diagnosis and treatment are essential for favourable outcomes.
Restoration of the worn dentition using aesthetic dental materials: an evidence-based guide to technique and material selection
Authors: Mehta Shamir B , Banerji Subir , Feito Jose Suarez , Loomans Bas AC 
Published: November 2024

There are several techniques and dental materials that can be used for the restorative rehabilitation of the worn dentition. Currently, however, there is the lack of clear scientific data to support the superiority of any given approach. An evidence-based overview is presented in this article, to help clinicians navigate this difficult decision-making process. CPD/Clinical Relevance: This article collates the research, aiming to appraise the current techniques and materials available for the restorative rehabilitation of the worn dentition.
Anterior aesthetics without dysfunction: a case report. Part 1: the operative dental procedure
Authors: OBE Raj Raja Rayan 
Published: November 2024

Marketing cosmetic dentistry is financially fashionable. Anterior aesthetic reconstructions are an artform showcasing the dental technician's skill. There is a perceived concern that anterior reconstructions that do not consider the functional features of the mutually protected occlusion, may, in susceptible patients, lead to dysfunction with its possible consequences. This series of three articles examines the restoration of worn upper anterior teeth with a plan for failure. CPD/Clinical Relevance: The mutually protected occlusion.
Advancing just and sustainable urban transitions: strengthening the role(s) of African universities
Authors: Patel Zarina 
Published: November 2024

The distinctiveness of urban processes and dynamics in Africa are of global significance. Achieving sustainable transitions in African cities must necessarily engage with theory and practice, which are derived out of context, and applied in systems and structures that are not globally understood. As sites of knowledge production, universities on the continent have a key role to play in addressing Sustainable Development Goal 11, which seeks to make cities sustainable. The ‘third mission’ of universities, which involves shaping societal benefits, extends their traditional mandates of research and higher education teaching beyond and across academic disciplines, to engage in local and global partnerships. Evidence from a range of knowledge co-production programmes anchored at African universities show that transdisciplinary approaches have made positive contributions to society. With the goal of realising the full potential of sustainability transitions, a network of scholars convened around a series of workshops to understand and enhance the effectiveness of the New African Urban University. Through processes of knowledge exchange, the network showed that realising the full potential is hampered by challenges of working across and beyond disciplines, highlighting the structural and systemic shifts required within African universities. Furthermore, partnering across the Global North and South in international transdisciplinary programmes is beset by power dynamics that shape assumptions and practices based on universalised assumptions about both theory and practice. This article outlines dimensions of an agenda to inform a more global and inclusive positioning of African universities as agents of social change.
Comparison of ranging precision of a dual-comb with different phase-locking methods
Authors: Shi Jin , Meng Fei , Liang Cui , Lin Baike , Tian Haochen , Fang Zhanjun , Huang Tengchao 
Published: November 2024

This research investigates the time-of-flight (TOF) ranging precision of a dual-comb system, utilizing three distinct phase-locking methods. We continuously collected ranging values over a period of approximately 20 min, then compared the ranging precision across averaging times spanning from 1 µm to 262 s, during which the Allan deviation floor of the TOF ranging is also determined. The results highlight that the dual-comb with two frequency modes locked to two cavity-stabilized continuous-wave (CW) lasers sustains superior ranging precision, achieving an Allan deviation floor of 35 nm at an averaging time of 8 s. Locking the repetition frequencies to a hydrogen maser results in lower precision in comparison to the free-running method for averaging times under 16 µm, and thereafter matches to the free-running precision up to an averaging time of 8 s. These findings are further analyzed through the relative phase noise of the dual-comb’s repetition frequencies.
Trefoil Factor Protein 3 (TFF3) as a Guardian of the Urinary Bladder Epithelium
Authors: Erman Andreja , Dragin Jerman Urška , Peskar Dominika , Šešelja Kate , Bazina Iva , Baus Lončar Mirela 
Published: November 2024

Summary Trefoil factor family (TFF) peptides have been examined primarily in the gastrointestinal tract, where they play an important role in the epithelial regeneration. The therapeutic effects of TFFs, particularly the TFF3 protein, have been well studied in humans and in animal models of gastrointestinal injury, whereas little is known about their occurrence and function in the urinary bladder. In this study, we investigated the presence, location, and function of Tff3 in the urinary bladders of wild-type mice (Tff3WT) and compared them with Tff3 knockout mice (Tff3KO) using molecular and microscopic methods at the light and electron microscopic level. Our results show that Tff3 is expressed in the superficial cells of the urothelium, where it colocalizes with the uroplakin UP1b as one of the fundamental structural components of the apical plasma membrane, which is an important component of the blood-urine permeability barrier. Analysis of the urothelium with experimentally induced injury revealed that injury is more severe in Tff3KO mice and urothelial regeneration is attenuated compared with Tff3WT mice, suggesting that Tff3 plays a fine-tuned role in homeostasis and protection of the urothelium. This study provides the first data on the precise location and function of Tff3 in the bladder epithelium. (J Histochem Cytochem XX. XXX–XXX, XXXX)
Development and feasibility of an mHealth intervention for psychoeducational support of Nigerian women diagnosed with breast cancer undergoing chemotherapy: A pilot randomized controlled trial
Authors: Akingbade Oluwadamilare , Hong Ka Yi , Ayo Oluwabukola Sharon , Alade Adetutu Sefinat , Lawal Moshood Akinwumi , Somoye Ibironke Elizabeth , Adediran Victoria , Sado Olamide , Chow Ka Ming 
Published: November 2024

Background
Breast cancer (BC) remains a significant health burden globally, with high incidence and mortality rates, particularly in Nigeria. Chemotherapy, a common treatment modality for BC, often leads to various physical and psychological side effects, impacting patients’ quality of life. Despite the growing use of mobile health (mHealth) interventions to provide psychoeducational support, there is a paucity of evidence regarding their feasibility and acceptability among Nigerian women with BC.

Objective
To develop and investigate the feasibility and acceptability of a mHealth psychoeducational intervention (mPEI) named the ChEmo Nurse Breast cancer Application (CENBA) programme.

Methods
A multi-centre, assessor-blinded, parallel-group pilot randomised controlled trial (RCT) was conducted at Lagos State University Teaching Hospital (LASUTH) and Lagos University Teaching Hospital (LUTH). Thirty women newly diagnosed with BC and undergoing chemotherapy were randomly assigned to an intervention or a control group. The intervention group received the CENBA programme, which included BC education, coping skills training, a discussion forum, and nurse-led consultations, delivered via a mobile application and phone calls over six weeks. The control group received standard care. Feasibility was assessed through consent, attrition, and completion rates, while acceptability was explored via qualitative interviews.

Results
The completion rate was 93.3%. Qualitative data indicated that participants found the intervention beneficial, particularly appreciating the educational content and the emotional support provided through the discussion forum and nurse consultations.

Conclusion
The CENBA programme was perceived as a feasible and acceptable mHealth intervention for providing psychoeducational support to Nigerian women with BC undergoing chemotherapy. These findings suggest that the CENBA programme could be a valuable tool in addressing the psychoeducational needs of this population, warranting further investigation in a full-scale RCT.

Trial registration
This manuscript reports a feasibility study preceding the full trial, which was registered with the United States Clinical Trials registry (number NCT05489354).
Global Prevalence and Clinical Manifestations of Celiac Disease Among First-Degree Relatives: A Systematic Review and Meta-Analysis
Authors: Karimzadhagh Sahand , Abbaspour Elahe , Ghodous Shahriar , Poursadrolah Selvana , Jafari Maryam , Mazloom Sina , Mosavi Mohadese , Makharia Govind K. , Rostami-Nejad Mohammad 
Published: November 2024

INTRODUCTION:
First-degree relatives (FDRs) of patients with celiac disease (CeD) are at high risk for developing CeD. We conducted a systematic review and meta-analysis to estimate CeD prevalence and clinical manifestations by analyzing studies that used the anti-tissue transglutaminase antibody test for screening.

METHODS:
In this systematic review with meta-analysis, studies published in PubMed, Web of Science, Embase, and Scopus were searched up to January 11, 2024, using keywords related to CeD and FDRs. Random-effects models were used, with heterogeneity assessed using the Cochran Q test and the I
2 statistic performed in STATA 18.

RESULTS:
Of 8,764 studies screened, 34 studies involving 10,016 FDRs of patients with CeD were included. The pooled estimates for seroprevalence and the biopsy-confirmed CeD prevalence in FDRs were 11% (95% CI: 9%–13%) and 7% (95% CI: 6%–9%), respectively. Daughters and sisters had the highest prevalence rates at 23% and 14%, compared with sons and brothers at 6% and 9%, respectively. Regional analysis revealed the highest seroprevalence estimates in Hungary (24%) and Cuba (19%), while the highest prevalence of biopsy-confirmed CeD was reported in Serbia (16%) and the United States (15%). Abdominal pain (42%), bloating (39%), and flatulence (38%) were the most common gastrointestinal symptoms, while 34% of FDRs with CeD were asymptomatic. In addition, pallor was the most frequent nongastrointestinal symptom (54%).

DISCUSSION:
Approximately 1 in 14 FDRs of patients with CeD is estimated to have CeD, with 1 in 4 daughters, 1 in 7 sisters, 1 in 11 brothers, 1 in 16 sons, and 1 in 20 fathers and mothers could be affected. Routine screening for FDRs could support early detection and management of CeD.
Existence of solutions for a class of quasilinear Schrödinger equations with Choquard-type nonlinearity
Authors: Shen Zifei , Yang Ning 
Published: November 2024

Abstract
For the following quasilinear Choquard-type equation:

−
Δ
u
−
Δ

(

u

2

)

u
+
V

(

x

)

u
=

(

I

μ

*

∣
u
∣

p

)

∣
u
∣

p
−
2

u
,

x
∈

R

N

,

-\Delta u-\Delta \left({u}^{2})u+V\left(x)u=\left({I}_{\mu }* {| u| }^{p}){| u| }^{p-2}u,\hspace{1em}x\in {{\mathbb{R}}}^{N},

where

N
≥
3
,
0
<
μ
<
N

N\ge 3,0\lt \mu \lt N

,

V

(

x

)

=
a
−

b

1
+

∣

x

∣

2

V\left(x)=a-\frac{b}{1+{| x| }^{2}}

,

1
<
a
<
+
∞

1\lt a\lt +\infty

,

0
<
b
<

1

2

0\lt b\lt \frac{1}{2}

,

2

(

N
+
μ

)

N

<
p
<

2

(

N
+
μ

)

N
−
2

\frac{2\left(N+\mu )}{N}\lt p\lt \frac{2\left(N+\mu )}{N-2}

, and

I

μ

{{I}}_{\mu }

is the Riesz potential. Our work is finding the positive solutions and the ground-state solutions. Using a change of variables method, we overcome the difficulties which the quasilinear term may bring us and consider the corresponding functional with variational arguments. Then, we establish the nonexistence results via the Pohožaev identity.
Getrennte Wege der Rezeption: Susanne Hornfecks Roman Ina aus China in Taiwan und Festlandchina
Authors: Weicheng Yu 
Published: November 2024

Abstract
Hornfeck’s novel “Ina aus China” tells the story of a little girl who is taken from Shanghai to safety in Germany before the Japanese attack on China, and who moves to Taipei after the end of the civil war. Its popularity in Taiwan, Germany, and mainland China differs significantly. While research on Hornfeck’s work has stagnated in mainland China since the publication of translations by Huang Lingxiao and Nelly Ma in 2010, the publisher’s marketing strategy has made Hornfeck famous in Taiwan. Dedicated to the translation and publication of Hornfeck’s novel and its reception in academic and non-academic contexts, this paper addresses the influence of censorship, collective memory, marketing strategies on its reception in the People’s Republic and in Taiwan.
Price estimation and visual evaluation of actual white fabrics used for dress shirts and their photographic images
Authors: Maruyama Tomoya , Kim KyoungOk , Takatera Masayuki 
Published: November 2024

Abstract
Consumers recognize the appearance and texture of fabric through viewing photographic images on E-commerce. However, the relationship between evaluations of the actual fabric and its image remains unclear. To understand the evaluation difference between actual fabric and its image, we investigated the relationship of visual evaluations including the price evaluation between actual white fabrics used for dress shirts and their photographic images concerning the online purchase of items presented by their photos. Participants evaluated the impressions of 24 white fabrics (actual fabrics and their images), comparing them with a standard white fabric. Participants also estimated the prices of shirts hypothetically made from different fabrics. We compared the difference between the results for actual fabrics and images. We also carried out a principal component analysis of those impressions and examined the relationship among principal component analysis results, weave structure, and fabric materials and price estimation. In a comparison of actual fabric and image evaluations, the impression of glossiness and brightness differed, with the actual fabrics being rated significantly higher in terms of glossiness and brightness. These differences are due to the difference in media (i.e., direct viewing versus screen display), although the visual environment of the lighting and displays may have had an effect. In principal component analysis, the first principal components were Delicateness and Glossiness for both actual fabrics and their images. The second principal components were Lightness and Coolness for the images of fabrics and Lightness, Coolness, and Softness for the actual fabrics. Fabrics evaluated highly in the first principal component had high price estimations. Thus, it is clear that Delicateness and Glossiness affected the price evaluation for both actual white fabrics and their images. Fabrics with a high value of Delicateness and Glossiness were a poplin made of at least 95% cotton. In contrast, fabrics containing linen and having a small repeating dobby pattern with roughness were evaluated as having low Delicateness and Glossiness and were assessed at a lower price. Additionally, even in the case of blended fabrics such as a cotton–polyester fabric, the expected price was high for diagonal patterns such as stripes and checks. These results will be helpful in the procurement of fabrics with which to make clothing and in the marketing of clothing for E-commerce.