bluuebunny/crossref_metadata_2025_split huggingface dataset:
DESIGN, OPTIMIZATION AND IN VITRO EVALUATION OF ANTIFUNGAL ACTIVITY OF NANOSTRUCTURED LIPID CARRIERS OF TOLNAFTATE
Authors: GARDOUH AHMED , H. Faheim Samar , M. Solyman Samar 
Published: July 2019

Objective: The main purpose of this work was to prepare tolnaftate (TOL) loaded nanostructured lipid carriers (NLCs), Evaluate its characteristics and in vitro release study.
Methods: Tolnaftate loaded Nanostructured lipid carriers were prepared by the high shear homogenization method using different liquid lipids types (DERMAROL DCO® and DERMAROL CCT®) and concentrations, different concentration ratios of tween80® to span20® and different homogenization speeds. All the formulated nanoparticles were subjected to particle size (PS), zeta potential (ZP), polydispersity index (PI), drug entrapment efficiency (EE), Differential Scanning Calorimetry (DSC), Transmission Electron microscopy (TEM), release kinetics and in vitro release study was determined.
Results: The results revealed that NLC dispersions had spherical shapes with an average size between 154.966±1.85 nm and 1078.4±103.02 nm. High entrapment efficiency was obtained with negatively charged zeta potential with PDI value ranging from 0.291±0.02 to 0.985±0.02. The release profiles of all formulations were characterized by a sustained release behavior over 24 h and the release rates increased as the amount of surfactant decreased. The release rate of TOL is expressed following the theoretical model by Higuchi.
Conclusion: From this study, It can be concluded that NLCs are a good carrier for tolnaftate delivery
ANALYSIS OF PRESCRIPTION INDICATORS FOR OUTPATIENTS WITH HEALTH INSURANCE IN OUTPATIENTS DEPARTMENT AT CAN THO UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL IN THE PERIOD 2017-2018
Authors: Nguyen Hung Phuc , Vo Thi My Huong , Nguyen Huynh Truc Mai 
Published: July 2019

Objective: The main objective of this study was to evaluate the drug prescription parameters and to find out the elements had an influence on the prescribing practice of doctors’.
Methods: A descriptive cross-sectional study was conducted to collect 300 outpatient drug prescriptions and 30 questionnaires of physicians during the period of 2017-2018. The data were analyzed according to WHO’s the guideline.
Results: Average number of drug per prescription: 3.73, percentage of drugs prescribed by generic or international name (INN): 100%, percentage of prescriptions with an antibiotic prescribed: 24%, of β-lactam antibiotics group, including cephalosporin (31.17%) and aminopenicillin (27.27%), accounted for the highest percentage of using in antibiotic groups with a total of 58.44%, of corticosteroid: 12%, of vitamin: 27.3%, of drugs prescribed including in the Essential Medicines List issued by the Ministry of Health: 35.3%. Average drug cost per prescription: 88,867 VNĐ. Percentage of drug costs for antibiotics (%): 7.48%, of corticosteroids (%): 1.85% and of vitamins (%): 5.25%.
Conclusion: The results of this research have identified some prescription indicators and elements affect the prescription indicators such as drug information, patient, drug, which may lead to intervention studies for evaluating changes in these issues in the outpatient clinic.
DESIGN AND OPTIMIZATION OF DOXORUBICIN HCL PRONIOSOMES BY-DESIGN OF EXPERIMENT
Authors: SRIKANTH  , Y. ANAND KUMAR , C. MALLIKARJUNA SETTY 
Published: July 2019

Objective: The present research work was designed to formulate and optimize doxorubicin HCl proniosomes by design of experiment (DoE).
Methods: A 4-factor, 3-level Box-Behnken design was used to explain multiple linear regression analysis and contour 3D plot responses. The independent variables selected were tween 20, cholesterol, hydration volume and sonication time; dependent variables percentage entrapment efficiency (PEE), mean vesicle size (MVS). Based on the Box-Behnken design 29 trial runs were studied and optimized for PEE and MVS. Further "Model F-Value" was calculated to confirm the omission of insignificant terms from the full-model equation to derive a multiple linear regression analysis to predict the PEE and MVS of niosomes derived from proniosomes. 3D plots were constructed to show the influence of independent variables on dependent variables.
Results: PEE of doxorubicin HCl proniosomes was found to be in the range of 40.21-87.5%. The polynomial equation for PEE exhibited a good correlation coefficient (0.5524) and the "Model F-Value" of 7.41 implies the model is significant. P-values less than 0.0500 indicate model terms are significant. The MVS of doxorubicin HCl proniosomes was found to be in the range of 325.2 nm to 420.25 nm. The mathematical model generated for MVS (R2) was found to be significant with model F-value of 54.22. There is only a 0.01% chance that a "Model F-Value" this large could occur due to noise (P<0.0500) and R2 value of 0.9004.
Conclusion: The DoE of Box-Behnken design demonstrated the role of the derived equation, 3D plot in predicting the values of dependent variables for the preparation and optimization of doxorubicin HCl proniosomes. The results suggest that doxorubicin HCl proniosomes can act as a promising carrier.
Recursos y competitividad en las subramas industriales de alimentos y bebidas en México (2004, 2009 y 2014)
Authors: Rios Nequis Eric Israel , Carbajal Cansino Daniela Edith , Hernández Solis Michelle Edith 
Published: July 2019

El trabajo de investigación abarca un análisis cuantitativo de los recursos con los que cuentan las subramas industriales de alimentos y bebidas en México para generar ventas y disminuir competenciaen sus respectivos ambientes para los periodos censales de 2004, 2009 y 2014. La evidencia muestra que los saldos de inventarios iniciales son un recurso valioso porque inciden positivamente en las ventas y erosionan competencia, por lo que denotan, con ello, los elementos necesarios para ser una ventaja competitiva sostenible o superior.
Evaluación de la calidad de los servicios administrativos como apoyo a la academia en la Escuela de Química de la Universidad de Costa Rica
Authors: Quesada Espinoza Javier 
Published: July 2019

El presente artículo tiene por objeto valorar la satisfacción del estudiantado respecto a la calidad del servicio administrativo brindado en la Escuela de Química de la Universidad de Costa Rica. Se empleó una adaptación del cuestionario del modelo SERVQUAL. Este fue aplicado a 102 estudiantes de la carrera. Se identificó una brecha importante entre la percepción del estudiantado sobre la calidad del servicio y la expectativa que se tenía de el. Todas las dimensiones del modelo presentaron una brecha similar, con una media global para el instrumento de -1.01 (s =0.31). Las dimensiones fueron correlacionadas con características sociodemográficas y se encontraron asociaciones con la edad y avance en la carrera del estudiantado. Se generaron modelos de regresión donde se destaca el avance mencionado como el predictor de la satisfacción. Los resultados muestran que existen puntos de mejora para brindar en servicio administrativo idóneo que apoye a la formación académica.
A comparison of patient experience, chair-side time, accuracy of dental arch measurements and costs of acquisition of dental models
Authors: Glisic Olja , Hoejbjerre Louise , Sonnesen Liselotte 
Published: July 2019

ABSTRACT

Objective:
To compare patient experience, chairside time, dental arch distances, and costs of dental models derived from intraoral scans and alginate impressions in pre-orthodontic children and young adolescents.

Materials and Methods:
Fifty-nine children and young adolescents (9–15 years, mean: 12.70 years) had an intraoral scan and an alginate impression prior to orthodontic treatment. During the procedures, chairside time was registered in minutes and patient experience was assessed by a Visual Analogue Scale questionnaire. Four maxillary dental arch distances were measured on digital models, on plaster casts, and directly in the mouth (intraoral). The cost of each procedure was presented graphically. Differences between the two procedures were tested by paired t-test and general linear model.

Results:
Patient experience was statistically better during intraoral scan compared with alginate impression regarding comfort, gag reflex, breathing, smell/sound, taste/vibration, and all statements concerning anxiety (P &lt; .05). No significant difference in chairside time between the two procedures was found. No statistically significant differences in dental arch distances between digital models and plaster casts were found, but dental arch distances measured intraorally differed significantly from both digital models and plaster casts (P &lt; .05). Cost calculation showed that the digital procedure was 10.7 times more expensive than the conventional procedure initially and, that after 3.6 years, the two procedures were equal in cost.

Conclusions:
Children preferred intraoral scan rather than alginate impression. Chairside time was equal for the two procedures as were the measurements of maxillary dental arch distances. The two procedures were equal in cost at 3.6 years.
Gender peculiarities of heart rate variability and hemodynamic basis of students’ educational activity
Authors: Biryukova Ekaterina V. , Vasilyuk Nikolaj A. , Andrianov Vladimir V. 
Published: July 2019

Aim of this study is to analyze gender peculiarities of physiological and psychophysical basis of students’ academic activity.
Materials and Methods. 32 medical students (16 men and 16 women, 19-22 years) were examined. Students were proposed an alternative method of a colloquium on normal physiology in the form of a computer test. The test consisted of 30 questions, time of testing was not limited. The test was considered to be done if the number of correct answers was 50% or more. Examination of students’ heart rhythm, hemodynamic, and psychological parameters was conducted before and immediately after the test. Cardio-intervalogram was recorded within 5 minutes using Varicard hardware-software complex. The Students t-test, Mann-Whitney analysis, Wilcoxon analysis were used to determine the significance of differences between parameters among and within groups of men and women. Relationships of the studied parameters were determined using Spearman’s method of rank correlation.
Results. It was demonstrated that fulfilment of the test by men was associated with reduction of hemodynamic parameters, with reduction of parasympathetic component and activation of sympathetic suprasegmental and central mechanisms of regulation of heart rhythm. Women showed stability of hemodynamic parameters and increase in suprasegmental influences on the dynamics of heart rhythm with lower average values. In correlation analysis conjugated pairs were found with the two components being different psychophysiological and physiological parameters, time and effectiveness of fulfilment of the test. The total number of conjugated and stable parameters were higher in women than in men both before and after computer testing.
Conclusions. Gender peculiarities of hemodynamic basis of academic activity of students were found. The described dynamics can be considered a manifestation of a higher stability and relatively lower mobility of regulatory mechanisms in women.
O elemento lógico representado pela retrodução na filosofia de Charles Sanders Peirce
Authors: D'Oliveira Júlio César 
Published: July 2019

Há muito ainda que se investigar e refletir sobre a filosofia desenvolvida por C.S. Peirce. Mas um elemento de especial relevância está anunciado nos meandros da sua Teoria da Percepção. Referimo-nos acerca do ato de retrodução e buscaremos destacar que sua primordialidade está ligada às operações do raciocínio, composto também dos elementos de dedução e indução. A importância deste breve estudo se eleva quando examina como tais elementos auxiliam na exegese fenomenológica peirciana, o que, como consequência, viabiliza ativamente a compreensão do mundo. Com isso, pretendemos aclarar ao máximo o conceito atribuído à retrodução, bem como a forma pela qual esta forma de raciocínio se manifesta em nossos comportamentos empíricos. Será satisfatório, deste modo, compreendê-la como uma atuação da mente que ocorre num átimo, enquanto ainda há algo de vago, cuja eclosão do sentido que capta o fenômeno se dá no horizonte da experiência, mas num momento em que os elementos externos ainda não estão aptos para gerar certeza cognitiva sobre qualquer coisa. Todavia, nem por isso possui papel insignificante, já que a partir deste sentimento sedimentam-se as bases para a dedução e a indução também atuarem, possibilitando a concretude das ações e construindo pontes do mundo interior para o universo exterior.
PEMANFAATAN MEDIA VIDEO TUTORIAL TERHADAP HASIL PEMBELAJARAN MENGGAMBAR SISWA KELAS VIII SMP NEGERI 1 MARDINDING
Authors: Lamrose Theoria , Budiwiwaramulja Dwi , Azmi Azmi , Muslim Muslim 
Published: July 2019

Abstrakini bertujuan untuk mengetahui peran penggunaan media video tutorial terhadap meningkatkan hasil gambar ilustrasi siswa kelas VIII SMP Negeri 1 Mardingding tahun 2018. Penelitian ini termasuk pada jenis penelitian eksperimen semu. Sampel yang digunakan dalam penelitian ini terdiri 23 hasil gambar pretest dan 23 hasil gambar posttest, Perlakuan tes dilakukan dengan sampel yang sama, pengambilan sampel dilakukan secara Random Sampling. Hasil penelitian menunjukan bahwa, pemanfaatan media video tutorial pada siswa kelas VIII SMP Negeri 1Mardingding, pretest dengan rata-rata 77,391 dan posttest dengan rata-rata 82,173 dengan demikian dapat di peroleh nilai t yaitu maka Ha di terima dan Ho di tolak, sehingga memiliki pengaruh yang signifikan terhadap hasil pembelajaran siswa kelas VIII SMP Negeri 1 Mardingding. Kata Kunci: video tutorial, hasil belajar, ilustrasi.AbstractThis study aims to determine the role of using video tutorial media to improve the illustration results of eight grade students of SMP Negeri 1 Mardingding in 2018. This research is included in a quasi-experimental type. The samples that used in this study consisted of 23 images of pretest and 23 results of posttes images, in which the treatment was carried out with the same sample, taking the sample was done in a random way. The results of the study showed that, the use of video tutorial media for eight grade students of SMP Negeri 1 Mardinding, Pretest with an average of 77,391 and posttest with an average of 82,173, thus can be obtained , do that Ha is accepted and Ho is rejected, so it has a significant influence on the learning, outcomes of eight grade students of SMP Negeri 1 Mardingding.Keywords: tutorial video, learning outcomes, illustration.
PENGEMBANGAN MODUL PENYELESAIAN GARIS LEHER PADA MATA KULIAH TEKNOLOGI BUSANA JURUSAN IKK FPP UNP
Authors: Mayangsari Vina , Adriani Adriani 
Published: July 2019

AbstrakPenelitian ini bertujuan untuk membuat media pembelajaran berupa Modul Penyelesaian Garis Leher pada jurusan IKK FPP UNP. Penelitian ini juga bertujuan untuk melihat kelayakan dari validitas dan praktikalitas modul tersebut. Penelitian ini menggunakan metode Research and Development (R&D). Proses dalam penelitian ini meliputi define, design dan develop. Teknik pengumpulan data yang dipakai pada penelitian ini adalah observasi dan angket, yang dimana data didapatkan dari uji validitas, dan uji praktikalitas dari dosen Pembina mata kuliah dan mahasiswa. Hasil dari penelitian ini yaitu hasil uji validitas didapatkan skor 87.1% dengan kategori sangat valid. Uji praktikalitas didapatkan skor 85.6% dengan kategori sangat praktis. Dapat disimpulkan bahwa Modul Penyelesaian Garis Leher ini dapat dikategorikan layak untuk digunakan sebagai media pembelajaran pada Mata Kuliah Teknologi Busana.Kata Kunci: media pembelajaran, busana, garis leher.AbstractThis research aims to produce an instructional media Neckline Finishing Module at IKK FPP UNP. This research also aims to know about advisability of validity and practicality of the module. This research was conducted using Research and Development (R&D). The method of this research include define, design and develop. The technique of accumulation data were observation and questionnaire, which the data was from validity test, practicality test of both small and large group of college student and also practicality test of advisor of Fashion Technology course subject. The result of this research show that from the validity of module score 87.1% which categorized as very advisability. Practicality test of module score 85.6% which categorized as very practical. So we can conclude that Neckline Finishing Module can be categorized as very advisable to use as instructional media at Fashion Technology subject. Keywords: instructional media, fashion, neckline.
DISIPLIN BELAJAR PADA PEMBELAJARAN MATA KULIAH PRAKTIK PROGRAM STUDI PENDIDIKAN KESEJAHTERAAN KELUARGA JURUSAN IKK FPP UNP
Authors: Nuraini Fatimah , Ernawati Ernawati 
Published: July 2019

AbstrakPenelitian dilatarbelakangi oleh kurangnya disiplin belajar pada pembelajaran mata kuliah praktik Program Studi Pendidikan Kesejahteraan Keluarga Keahlian Tata Busana yang dapat berdampak pada proses pembelajaran. Tujuan penelitian ini melihat kedisiplinan mahasiswa Program Studi Pendidikan Kesejahteraan Keluarga Keahlian Tata Busana dari aspek:1) ketepatan waktu, 2 kesiapan bertindak. Metodologi penelitian yang digunakan adalah deskriptif kuantitatif. Populasi berjumlah 144 orang dan sampel berjumlah 72 orang menggunakan teknik pengambilan sampel yaitu istematik random sampling. Teknik pengumpulan data menggunakan kusioner. Teknik analisis data menggunakan spss 16. Hasil penelitian menunjukkan bahwa disiplin belajar pada pembelajaran praktik dalam aspek 1) ketepatan waktu cukup (50%), 2) kesiapan bertindak cukup (58%). Kesimpulannya bahwa mahasiswa sebagian hadir tepat waktu, sebagian menyelesaikan tugas praktik tepat waktu dan sebagian mahasiswa yang mempersiapkan perlengkapan belajar. Saran penelitian ini adalah sebaiknya adanya kerjasama antara mahasiswa dan dosen untuk meningkatkan disiplin belajar pada pembelajaran praktik. Kata Kunci: disiplin, pembelajaran, praktik.AbstractThis research is motivated by the lack of discipline in learning practical subjects PKK Study Program in The IKK Departemenet of FPP UNP which can have an impact on the Fashion Skill PKK Study Program from aspects: 1) timeliness, 2) readliness to act. The research methodology used is descriptive quantitative. The population is 144 people and a sample of 72 is determined based on the sampling technique that is systematic random rampling. The technique of collecting data uses a questionnaire. Data analysis techniques uses spss 16. The results of the study show that discipline in practical learning in terms of aspects 1) timeliness is enough (50%), 2) readliness to act is enough (58%). The conclusion is that some of the students attend on time, some students complete assignments on time, some who complete the assignment on time, some students prepare learning equipment. The research suggestion is that there should be collaboration between lectures and students so that the discipline of learning in practical learning can be improved. Keywords: discipline, learning, practice.
STUDI BATIK TANAH LIEK KOTA PADANG (Studi Kasus di Usaha Citra Monalisa)
Authors: Oktora Nana , Adriani Adriani 
Published: July 2019

AbstrakMasalah dalam penelitian ini yaitu Batik Tanah Liek Citra Monalisa mengangkat dan mengembangkan kembali Batik Tanah Liek yang dulu sempat punah dengan cara membuat kembali motif-motif yang memang sudah menjadi ciri khas dari Minangkabau. Tujuan penelitian adalah untuk mendeskripsikan tentang bentuk motif Batik Liek Citra Monalisa. Metode penelitian menggunakan metode deskriptif kualitatif. Jenis data berupa data primer dan skunder. Teknik pengumpulan data melalui observasi, wawancara dan dokumentasi. Teknikanalisa data dilakukan model interaktif yang berkaitan dengan pokok permasalahan yaitu dengan reduksi data, penyajian data, dan pengambilan kesimpulan. Hasil penelitian yaitu Motif Tanah Liek Citra Monalisa dianataranya motif alam benda meliputi motif Rumah Gadang, Jam Gadang, Tabuik, Kapal Malin Kundang dan Rangkiang. Motif flora meliputi motif Sirih Gadang, Bungo Melati dan Bungo Rayo. Motif fauna meliputi motif Kabau Padati dan Burung Hong.Kata Kunci: motif batik, tanah like.AbstractThe problem in this study is the Citra Liek Batik Monalisa raised and redeveloped the Tanah Liek Batik which used to be extinct by making motifs that had become the hallmark of Minangkabau. The aim of the study was to describe the shape of the Batik Liek Citra Monalisa motif. The method of research uses a qualitative descriptive method. Types of data in the form of primary and secondary data. The technique of collecting data through observation, interviews and documentation. Techniques of data analysis carried out interactive models related to the subject matter, namely by data reduction, data presentation, and conclusion. The results of the study were the Monalisa Image Liek Motif, which included natural motifs of objects including the motifs of the Gadang House, Gadang Clock, Tabuik, Malin Kundang Ship and Rangkiang. Flora motifs include Sirih Gadang motifs, Bungo Melati and Bungo Rayo. The fauna motif includes the Kabau Padati and Hong Bird motifs. Keywords: batik motif, liek soil.
ANALISIS KREATIVITAS SISWA KELAS III SD SWASTA YAYASAN WANITA KERETA API “YWKA” MEDAN DALAM PEMBELAJARAN MENGGAMBAR BINATANG
Authors: Surbakti Teguh Iman Perdana , Zulkifli Zulkifli , Atmojo Wahyu Tri , Mesra Mesra 
Published: July 2019

AbstrakPenelitian ini dilakukan di SD Swasta Yayasan Wanita Kereta Api “YWKA” Medan yang bertujuan untuk menganalisis kreatifitas dan potensi siswa dalam pembelajaran menggambar binatang bertema burung. Metode pengumpulan data penelitian ini adalah observasi, wawancara dan dokumentasi. Populasi dalam penelitian ini adalah seluruh siswa kelas III SD Swasta Yayasan Wanita Kereta Api “YWKA” Medan. Pengambilan sampel menggunakan teknik sampel jenuh (semua anggota populasi dijadikan sampel) diperoleh sampel penelitianya itu sebanyak 25 orang dari kls III. Hasil penelitian ini menunjukkan bahwa aspek yang dikembangkan dalam teori Utami Munandar 4P dalam pengembangan kreativitas yaitu pribadi kreatif, pendorong (press), proses kreatif, dan produk berdasarkan hasil nilai rata-rata yang telah dinilai oleh 3 tim penilai secara keseluruhan pada karya menggambar binatang bertema burung siswa kelas III SD Swasta Yayasan Wanita Kereta Api “YWKA” Medan. Hasil penelitian menjelaskan bahwa aspek pribadi secara keseluran baik karena dari hasil karya siswa sudah memenuhi ketiga deskriptor dari empat deskriptor yang sudah ditentukan. Pendorong secara keseluruhan cukup baik karena karya siswa hanya memenuhi dua deskriptor dari empat deskriptor yang ditentukan. Aspek proses secara keseluruhan cukup baik karena karya siswa hanya memenuhi dua deskriptor dari empat deskriptor yang ditentukan. Aspek produk secara keseluruhan cukup baik karena karena karya siswa hanya memenuhi dua deskriptor dari empat deskriptor yang ditentukan. Kata Kunci: analisis, kreativitas, menggambar binatang.AbstractThis research was conducted by the SD Swasta Yayasan Wanita Kereta Api “YWKA” Medan which aims to analyze the potential of students in bird-themed animal learning. Data collection methods in this study are observation, interviews and documentation. This population study is all third grade students from the SD Swasta Yayasan Wanita Kereta Api “YWKA” Medan. Sampling using saturated sample techniques (all members of the population used as samples) obtained a study sample of 25 people from third grade. The theory of creativity and motivation is based on the results of a study in Utami in the third grade of 4P Munandar SD Swasta Yayasan Wanita Kereta Api “YWKA” Medan. The results of this study are the three descriptors of four predefined descriptors. The overall driver is quite good because only descriptors from four descriptors are specified. The whole process is quite good because it only fulfills two explanations of the four specified explanations. The whole product is quite good because it only satisfies two descriptors from the four specified descriptors. Keywords: analysis, creativity, drawing’s animals.