bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking precision oncology by establishing a nationwide comprehensive genomic profiling and molecular tumor board platform for patients with advanced cancer: the BALLETT study
Authors: Volders Pieter-Jan , Aftimos Philippe , Dedeurwaerdere Franceska , Martens Geert , Canon Jean-Luc , Beniuga Gabriela , Froyen Guy , Huysse Jacques Van , De Pauw Rebecca , Prenen Hans , Lambin Suzan , Decoster Lore , Vaeyens Freya , Rottey Sylvie , Dam Pieter-Jan Van , Decoster Lynn , Rutten Annemie , Schreuer Max , Loontiens Siebe , Meulen Joni Van der , Mebis Jeroen , Cuppens Kristof , Tejpar Sabine , Bempt Isabelle Vanden , De Grève Jacques , Schröder David , Marcke Cédric van , Bulcke Marc Van Den , de Azambuja Evandro , Punie Kevin , Maes Brigitte 
Published: November 2024

Abstract

The increasing complexity of advanced-stage cancer management, coupled with the growing availability of targeted therapies, necessitates innovative approaches to treatment decision-making. The Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT) study evaluated the feasibility and impact of implementing comprehensive genomic profiling (CGP) across multiple laboratories and integrating genomic data into clinical decision-making for patients with advanced cancers. This prospective, multi-center study enrolled 872 patients with advanced solid tumors across 12 Belgian hospitals. CGP was performed using a standardized next-generation sequencing panel across nine laboratories, with results reviewed by a national molecular tumor board (nMTB) for treatment recommendations. CGP was successfully performed in 93% of sequenced patients (756/814), with a median turnaround time from inclusion to nMTB report of 29 days. Actionable genomic markers were identified in 81% of patients, substantially higher than the estimated 23% if restricting to nationally reimbursed panels. The nMTB provided treatment recommendations for 69% of patients with successful CGP. Of those with recommendation uptake data available (n = 454), 23% received the matched treatment. Reasons for non-implementation included physician’s choice (27%), trial not conducted at an acceptable distance (21%), and rapid clinical deterioration (12%). CGP also revealed potential germline variants in 15% of cases, prompting recommendations for genetic counseling. The BALLETT study demonstrates the feasibility of implementing standardized CGP across multiple laboratories and its potential to identify actionable targets in a majority of patients with advanced cancers. However, the translation of genomic findings into clinical practice faces challenges, including drug access and the need for improved decision-support tools. These findings underscore the importance of addressing implementation barriers to fully realize the potential of precision oncology in routine clinical care.
Association of CUN-BAE, BRI and Hypertension Among Adolescents Aged 12-18 Years in US, NHANES, 1999-2018
Authors: Yuan Xiaojing , Long Taihua , Zhong Xiangbin , Cai Honglin , Li Yuting , Zeng Xia 
Published: November 2024

Abstract

Background
CUN-BAE (Clínica University of Navarra - Body Fat Estimator) and BRI (Body Rounds Index) are associated with adults’ hypertension. We aimed to assess whether CUN-BAE, BRI is associated with the prevalence of hypertension in adolescents and whether it is superior to body mass index (BMI).
Methods
12,605 adolescents aged 12–18 years were enrolled from the National Health and Nutrition Examination Survey (NHANES). Correlations between CUN-BAE, BRI and the prevalence of hypertension in adolescents were analyzed using logistic regression. Receiver operating characteristic curve (ROC curve) was used to predictive value for the prevalence of hypertension in adolescents.
Results
CUN-BAE, BRI, BMI were positively associated with the prevalence of hypertension in adolescents (The multivariable OR (95%CI): 4.47 (3.44–5.82), for CUN-BAE, 2.95 (2.38–3.66) for BRI, and 3.97 (3.11–5.07) for BMI, for quartiles 4 versus quartile1, respectively), and the relationship was monotonically increasing (P < 0.001 for All trends). The effects of CUN-BAE, BRI and BMI on hypertension were more pronounced in participants aged 15–18 years. Significant association between CUN-BAE and prevalence of hypertension in adolescents observed only in male. BRI had more significant effects on hypertension in female. CUN-BAE and BRI did not show significant superiority over BMI in predicting the prevalence of hypertension in adolescents.
Conclusions
CUN-BAE and BRI were significantly and positively associated with the prevalence of hypertension in adolescents, especially among participants aged 15 years and older. But they were not a substitute for BMI. CUN-BAE and BRI were unique in assessing the risk of hypertension in adolescents.
Evaluating the effectiveness of psychological first aid training for disaster nursing: a mixed-method study
Authors: Yılmaz Emel Bahadır 
Published: November 2024

Abstract

Background
Psychological first aid (PFA) training significantly improves appropriate psychosocial response and PFA skills in supporting people in acute distress, thus increasing self-efficacy and promoting resilience. Nevertheless, nurses' perceptions of disaster preparedness are not at the desired level. More studies are needed to increase the knowledge, skills and preparedness of nurses for better disaster preparedness and management in disaster situations.
Objectives
This study aimed to evaluate the effect of psychological first aid training on nursing students' perception of self-efficacy in disaster intervention and disaster preparedness.
Methods
This study was conducted in a nursing school in Türkiye. The sample consisted of 62 fourth-year nursing students. Thirty-two students in the intervention group participated in psychological first aid training. The control group consisted of 30 students who did not participate in the training. Data were collected with the Descriptive Information Form, Metaphor Determination Form on Psychological First Aid, Preparedness Perception Scale of Disaster in Nurses, and Disaster Response Self-Efficacy Scale.
Results
Psychological first aid training increased both students' self-efficacy level in disaster response and their perception of disaster preparedness (p < 0.05). Four categories were obtained in the metaphor analysis: need-related, help-related, growth and development-related, and struggle-related.
Conclusions
Psychological first aid training is effective in improving students' self-efficacy in disaster response and their perception of disaster preparedness and needs to be integrated into the curriculum.
What Increase Chance of Dementia among Asian Americans? Analysis of Nativity and Life Course Factors
Authors: Okada Jamil Judith Berard , Yang Michelle Shigi , Yu Roland Alfred , Du Lisa , Theng Bunnarin , Shen Gordon , Lee Wei-Chen 
Published: November 2024

Abstract

Objectives
The Alzheimer’s Association has reported a 746% increase in dementia-related deaths in Asian American populations between 2000 and 2018, the most significant rise compared to all other racial groups. Asian Americans face a unique myriad of obstacles and factors contributing to significant health disparities, including those in dementia. Our aim is to compare determinants and outcomes of dementia between US-born and foreign-born Asian Americans.
Methods
Data from the 2019–2022 National Health Interview Survey was analyzed to examine the relationship between nativity and dementia. Other life course risk factors and outcomes of having dementia were also included in the analysis. The study sample included 16,331 US-born and 126,978 foreign-born Asian Americans.
Results
Foreign-born Asian Americans were found to have a higher proportion of dementia compared to US-born Asian Americans (1.1%>0.4%, p = 0.0140). Risk factors that were found to significantly mediate the relationship between nativity and dementia included age > 65, ever being married, having some college education, and having Medicaid coverage. Foreign-born Asian Americans with dementia are more likely to suffer from depression (p < 0.001) and experience/have difficulty in social involvement (p < 0.001) compared to US-born Asian Americans with dementia.
Discussion
Our findings reaffirm that nativity contributes to the heterogeneous risk and outcomes of dementia in Asian Americans and the likelihood of having dementia is further mediated by life course factors. Interventions to support Asian American immigrants are needed to reduce the burden of dementia. More studies that identify nativity variations are also recommended to address health disparities that disproportionately affect older immigrants.
Toxin producing cyanobacteria and phytoplankton in Antarctic and sub-Antarctic waters: a review
Authors: Brito-Echeverría Jocelyn , Pérez Pablo Andrés , Echeveste Pedro 
Published: November 2024

Abstract

The interaction between climate change and anthropogenic activities in Antarctica is facilitating the invasion of temperate microorganisms into its aquatic ecosystems, including toxic species that could impact these ecosystems. This review aims to identify the toxic cyanobacteria and microalgae species detected thus far in sub-Antarctic and Antarctic waters and to explore long-term trends in key environmental parameters—such as temperature, salinity, chlorophyll-a concentrations, and dust deposition—in the areas where these species have been found. To date, five marine species (Pseudo-nitzschia sp., Pseudo-nitzschia subcurvata, Alexandrium tamarense, Karenia papilionacea and Dinophysis spp.) and nine freshwater species (Nostoc sp., Phormidium spp., Planktothrix sp., Anabaena sp., Anagnostidinema pseudacutissimum, Oscillatoria sp., Microcoleus autumnalis, Phormidesmis priestleyi, and Wilmottia murrayi) have been identified as producing toxins and/or having the genes to potentially produce them. It is hypothesized that the environmental changes stemming from climate change and the increasing human presence in Antarctica will create conditions conducive to new invasions of toxic phytoplankton and cyanobacteria species, potentially resulting in harmful blooms with unpredictable consequences for Antarctic biota.
Evaluation Anti-porcine Reproductive and Respiratory Syndrome Virus Activity of Bacillus Strains
Authors: Zheng Yu-Wei , Chang Hui-Wen , Liu Je-Ruei 
Published: November 2024

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen in the swine industry, causing severe respiratory and reproductive issues in pigs and leading to substantial economic losses worldwide. This study investigates the antiviral potential of three Bacillus strains—Bacillus amyloliquefaciens LN, Bacillus licheniformis CK, and Bacillus velezensis AC—against PRRSV using the MARC-145 cell model. All three strains demonstrated significant prophylactic and direct-inhibitory effects against PRRSV, primarily through the inhibition of viral attachment and internalization, and a reduction in intracellular and extracellular viral loads. Notably, the cell-wall fraction of Bacillus velezensis AC upregulated type I IFN-dependent genes, including interferon-stimulated gene 15 (ISG15), myxovirus resistance 2 (Mx2), and 2'-5'-oligoadenylate synthetase 1 (OAS1). Additionally, all strains significantly reduced interleukin (IL)-8 expression, with reductions in tumor necrosis factor (TNF)-α levels observed in specific treatments, highlighting their immune-modulatory effects. These findings suggest that Bacillus amyloliquefaciens LN, Bacillus licheniformis CK, and Bacillus velezensis AC have potential as antiviral agents against PRRSV, offering alternative strategies for managing PRRSV infections in swine populations.
Optimized Single-Step Carbonization of Michelia Champaca Biomass for High-Performance Supercapacitor Electrodes
Authors: Shrestha Dibyashree 
Published: November 2024

Abstract

This study investigates the potential of Michelia Champaca, a hardwood, as a sustainable precursor for high-performance supercapacitor electrodes. Activated carbons were prepared using single-step carbonization at 400°C and 500°C (SSC-400°C and SSC-500°C) and double-step carbonization at 400°C (DSC-400°C) with all samples activated using H₃PO₄. The effects of carbonization temperature on the structural, morphological, and electrochemical properties of the resulting electrodes were examined. SSC-400°C exhibited superior electrochemical performance, with a specific capacitance of 292.2 F g⁻¹, energy density of 6.4 Wh kg⁻¹, and power density of 198.4 W kg⁻¹. Its optimized pore structure and surface chemistry contributed to enhanced performance. SSC-500°C showed slightly lower performance, while DSC-400°C demonstrated the lowest, suggesting that the double-step process may negatively impact structural and electrochemical properties. These findings highlight the potential of Michelia Champaca wood as a renewable source for high-quality activated carbon materials suitable for supercapacitor applications. Future research could focus on optimizing the carbonization process and exploring other precursors to further enhance electrode performance.
Generalized novel digital chaotic system control method with output sequence cycle length up to theoretical upper limit and FPGA implementation
Authors: Zeng Jian , Ding Qun 
Published: November 2024

Abstract

Many characteristics of chaotic system correspond to “confusion” and “diffusion” in cryptography, which makes chaotic system in the field of information security has been concerned by many scholars. If the chaotic system in the real number domain is directly applied to hardware devices with limited precision, the operation of data will be truncated and truncated in different degrees, and its performance cannot meet the demand of chaotic secure communication, which also affects the wide application of chaotic system in the field of practical engineering. In order to address this problem, a new method is proposed for the design of controlled digitised chaotic systems by introducing controlled functions to improve the digitised chaotic systems with controllable output sequence cycle lengths, and arbitrary number of controlled systems with the required period lengths of the output sequences can be designed. The process of constructing two digital nonlinear system models according to the controlled method is described in detail, and it is proved through specific theoretical analyses and experiments that the output sequence period length of the digital nonlinear system model is controllable and can reach the theoretical upper limit ; meanwhile, it is possible to design any number of digital nonlinear systems according to the proposed models. Further, a pseudo-random sequence generator (PRNG) based on digitised chaotic system is designed and implemented in hardware, and finally an encryption system is constructed to verify the practical engineering usability of the pseudo-random sequence generator.
Loneliness among Chinese adults: Validation of the ALONE scale and its association with age
Authors: Ma Ying , Leung Patrick , Berg-Weger Marla , Cheung Monit , Malmstrom Theodore K. , Ma Guixia , Chen Xin 
Published: November 2024

Abstract

Background This study translated the 5-item ALONE scale into Chinese and psychometrically validated the translated scale among Chinese adults, and determined the association between age and loneliness.
Methods An online cross-sectional survey was conducted using the Wenjuanxing platform in mainland China in 2022. A total of 2,019 Chinese adults (≥ 18 years) participated in this study.
Results The translated ALONE scale demonstranted an acceptable internal consistency (Cronbach’s α = 0.600) and a moderate association with the ULS-8 (r=0.606). Scores of the translated scale showed a stronger association with self-rated health than with other related variables. Receiver Operating Characteristic (ROC) curve analysis identified scores of 10 or greater as optimal for loneliness screening (sensitivity=0.88, specificity=0.74, and Area Under the Curve=0.899). Results from a locally weighted scatterplot smoothing (LOESS) curve found a non-linear age distribution of loneliness, marked by two minor peaks after adjustment (at ages 25 and age 50 for the total sample). The loneliness levels were lowest among older adults (≥ 60 years). Females reached peak loneliness approximately 10 years later than males. Logistic regression identified an inverse association between age and loneliess levels.
Conclusions This study confirms the reliability and validity of the Chinese ALONE Scale for loneliness screening. Additionally, our findings offer valuable insights into vulnerability to loneliness across the lifespan within the Chinese context, supporting the development of age-specific interventions to address loneliness effectively.
A Deep Reinforcement Learning Approach to Solving the Digital Billboard Optimal Placement Problem Based on Multi-Source Spatiotemporal Data Fusion
Authors: Zhou Junyuan , Wang Shaohua , Yan Haowen , Li Xiao , Liang Haojian , Li Pengze 
Published: November 2024

Abstract

The study presents a study on optimizing the spatial location of digital billboards in urban environments using multi-source big data and deep reinforcement learning methods. Focusing on the Fifth Ring Road in Beijing, China, the study aims to solve the Maximum Coverage-Digital Billboard Localization Problem (MC-DBLP) model. This paper describes the data collection and preprocessing process, the use of geo-detectors and attention models, and an evaluation of the effectiveness of deep reinforcement learning methods compared to traditional optimization solvers. The authors propose a new solution model for the digital billboard placement problem. The method is universal and scalable, which can provide a reference for similar problems in other fields. Multi-sourced spatiotemporal data are incorporated to unify the data format of factors and, an attention model multi-decoder (AMMD), Gurobi solver, and a heuristic algorithm are used to solve the problem. The results show that the Gurobi solver produces the best solution results, and the optimal digital billboard locations are obtained. In the future, the authors plan to select more various and complex influencing factors and explore more efficient and accurate algorithm models to better solve location optimization problems.
Phytoplankton Assemblages as Indicators of Environmental Changes in Afrotropical Reservoirs: A Study of Hydrological Impacts and Water Quality
Authors: Akachukwu Esther N. , Obi-Iyeke Grace E. , Ajai Alexander I. , Mohammed Adamu Z. , Arimoro Francis O. 
Published: November 2024

Abstract

Reservoirs are crucial to Nigeria's landscape and electricity generation; however, their establishment poses significant ecological challenges, particularly concerning water quality and phytoplankton dynamics. This research investigates phytoplankton assemblages in ten reservoirs across Niger State, Nigeria. Sampling was conducted bi-monthly from June 2019 to March 2021, evaluating physical and chemical parameters alongside phytoplankton composition. A two-way ANOVA was used to assess the spatial and seasonal variation in environmental conditions, while Canonical Correspondence Analysis (CCA) was used to explore the relationships between phytoplankton assemblages and environmental variables. Our findings reveal differing levels of organic pollution across the reservoirs, affirming phytoplankton as effective bioindicators of ecological health. This study emphasizes the necessity for strategic management practices to safeguard aquatic ecosystems in alignment with sustainable development goals.
Regulatory Pathways of Long Non-coding RNAs and MicroRNAs in Sepsis-Induced Cardiomyopathy: Prognostic Biomarkers and Therapeutic Targets
Authors: Eini Peyman , amini Nahal Babaeian , Farzan Parsa , Etemady Kimiya , Eini Pooya , Doosti-Irani Amin 
Published: November 2024

Abstract

Sepsis-induced cardiomyopathy (SCM) is a life-threatening complication of sepsis, marked by temporary myocardial dysfunction. Emerging evidence highlights the critical roles of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in regulating the molecular pathways involved in SCM, including inflammation, oxidative stress, and apoptosis. These non-coding RNAs (ncRNAs) are increasingly recognized as valuable diagnostic and prognostic biomarkers, as well as promising therapeutic targets. This review explores the potential of lncRNAs and miRNAs in SCM, focusing on their regulatory functions and therapeutic applications. Key miRNAs, such as miR-495 and miR-21-3p, are highlighted as early diagnostic indicators and modulators of disease progression. Similarly, lncRNAs like MALAT1 and HOTAIR play crucial roles in controlling fibrosis and inflammation within the myocardium. Therapeutic strategies include the use of miRNA mimics to restore miRNA function, antagomiRs to inhibit overexpressed miRNAs, and the modulation of lncRNA expression to mitigate SCM progression. Advanced delivery methods, including CRISPR/Cas9 gene-editing technology, are discussed as innovative approaches to enhance the specificity and efficacy of ncRNA-based therapies. In conclusion, ncRNAs offer significant potential as biomarkers and therapeutic agents in SCM, presenting new avenues for targeted treatment. However, further research is required to address challenges related to delivery, specificity, and long-term safety in clinical applications.
Biological Soil Crusts Reveal New Species Records and Diverse Cyanophytes in the Arid Suburbs of Punjab, Pakistan: Implications for Algal Systematics and Evolution
Authors: Minhas Lubna Anjum , Kaleem Muhammad , Jabeen Amber , Waqar Rooma , Farooqi Umer , Mumtaz Abdul Samad 
Published: November 2024

Abstract

In the arid suburbs of Rawalpindi, we found as many as thirty species that belonged to seventeen genera and three major orders in the class Cyanophyceae. Based on species count, the orders Nostocales and Oscillatorales revealed more diverse (36.6%) as compared to the Chroococcales (16.6%). The genera Oscillatoria and Nostoc with 6 species (16.6%) were the most represented followed by Anabaena (10%), Chroococcus (10%), Phormidium, and Lyngbya (6.6% each). Several genera such as Calothrix, Parakomarekiella, Gloeothecca, Aphanotheca, Leptolyngbya, Synechococcus, Spirulina, Planktothrix, Westilliopsis and Compactonostoc with one species (33%) each remained least represented. Most interestingly, Nostoc pruniforme, Anabaena oryzae, Anabaena gelatinicola, Calothrix javanica, Westiellopsis prolifica, Parakomarekiella sesnandensi, Compactonostoc shennongjiaensis, Oscillatoria lutea, Planktothrix agardhii, and Leptolyngbya boryana are being reported for the first time as residents of biocrust soil substrate. Data collation on species distribution did not reveal any endemic species however recognized the occurrence of species in Pakistan that are not yet reported from Asia. Hence, the arid suburbs of Rawalpindi are rich in cyanophytes, exhibiting local variation with several new records. Most of these strains showed an in vitro culturing response, and therefore warrants probing their ecological functioning in the arid environments of the Asian continent.