bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes
Authors: Das Dibyendu , Sarkar Sanjib , Bordoloi Jijnasa , Wann Sawlang Borsingh , Kalita Jatin , Manna Prasenjit 
Published: September 2018

AbstractOver the last decades, the incidence of type 2 diabetes (T2D) is increasing substantially. Emerging evidences from epidemiological studies have shown the association between higher intake of soy isoflavones and reduced risk of T2D and its associated health risks. Daidzein, a soy isoflavone, has been found to have a promising therapeutic potential in managing T2D pathophysiology. Fermented soybean is the major source of daidzein; however, it can also be formed via the consumption of its glycosylated moiety, daidzin with subsequent hydrolysis by intestinal bacterial enzyme. Many studies reported the prophylactic effect of daidzein on the improvement of hyperglycemia, insulin resistance, dislipidemia, obesity, inflammation, and other complications associated with T2D. The molecular mechanisms underlying the action of daidzein include diverged pathways where daidzein has been shown to interact with several signaling molecules and receptors to achieve desirable effect. Although the specific molecular mechanism is still elusive, further studies are thus needed to understand it in detail. In this review, we discuss the antidiabetic potential of daidzein with respect to the evidences from various clinical, preclinical, and cell culture studies and the underlying molecular mechanism in a precise way to have a comprehensive account on this isoflavone with promising therapeutic potential. © 2018 BioFactors, 44(5):407–417, 2018
Predicting the risk for aberrant opioid use behavior in patients receiving outpatient supportive care consultation at a comprehensive cancer center
Authors: Yennurajalingam Sriram , Edwards Tonya , Arthur Joseph A. , Lu Zhanni , Najera John , Nguyen Kristy , Manju Joy , Kuriakose Leela , Wu Jimin , Liu Diane , Williams Janet L. , Reddy Suresh K. , Bruera Eduardo 
Published: September 2018

BACKGROUNDOpioid misuse is a growing crisis. Patients with cancer who are at risk of aberrant drug behaviors are frequently underdiagnosed. The primary objective of this study was to determine the frequency and factors predicting a risk for aberrant opioid and drug use behaviors (ADB) among patients who received an outpatient supportive care consultation at a comprehensive cancer center. In addition, the screening performance of the Cut Down‐Annoyed‐Guilty‐Eye Opener (CAGE) questionnaire adapted to include drug use (CAGE‐AID) was compared with that of the 14‐item Screener and Opioid Assessment for Patients With Pain (SOAPP‐14) tool as instruments for identifying patients at risk for ADB.METHODSIn total, 751 consecutive patients with cancer who were referred to a supportive care clinic were reviewed. Patients were eligible if they had diagnosis of cancer and had received opioids for pain for at least 1 week. All patients were assessed using the Edmonton Symptom Assessment Scale (ESAS), the SOAPP‐14, and the CAGE‐AID. SOAPP scores ≥7 (SOAPP‐positive) were used to identify patients who were at risk of ADB.RESULTSAmong the 729 of 751 (97%) evaluable consults, 143 (19.6%) were SOAPP‐positive, and 73 (10.5%) were CAGE‐AID–positive. Multivariate analysis revealed that the odds ratio of a positive SOAPP score was 2.3 for patients who had positive CAGE‐AID scores (P < .0001), 2.08 for men (P = .0013), 1.10 per point for ESAS pain (P = .014), 1.13 per point for ESAS anxiety (P = .0015), and 1.09 per point for ESAS financial distress (P = .012). A CAGE‐AID cutoff score of 1 in 4 had 43.3% sensitivity and 90.93% specificity for screening patients with a high risk of ADB.CONCLUSIONSThe current results indicate a high frequency of an elevated risk of ADB among patients with cancer. Men and patients who have anxiety, financial distress, and a prior history of alcoholism/illicit drug use are at increased risk of ADB.
Plate Design for and Cherry Picking of Bacterial RNAi Clones for Systematic Error Detection in High‐Throughput Caenorhabditis elegans RNAi Screens
Authors: Jagadeesan Sakthimala , Hakkim Abdul 
Published: September 2018

AbstractAutomated or semi‐automated high‐throughput RNAi screens are highly prone to systematic errors because of multistep repetitive protocols and extensive use of automated instruments. A well‐designed RNAi library can help detect and minimize systematic human and robotic errors. In this unit, we describe how to design an RNAi bacterial library for use in conjunction with the well‐studied nematode Caenorhabditis elegans for automated phenotypic screens. We provide strategies to design and assemble RNAi libraries to reduce or eliminate systematic errors. These strategies serve as a good quality‐control check and facilitate obtaining high‐quality data from a genome‐wide and sub‐library RNAi screen. © 2018 by John Wiley & Sons, Inc.
Interface‐Engineered Li7La3Zr2O12‐Based Garnet Solid Electrolytes with Suppressed Li‐Dendrite Formation and Enhanced Electrochemical Performance
Authors: Zhang Zhaoshuai , Zhang Long , Liu Yanyan , Wang Hongqiang , Yu Chuang , Zeng Hong , Wang Li‐min , Xu Bo 
Published: September 2018

AbstractHigh grain‐boundary resistance, Li‐dendrite formation, and electrode/Li interfacial resistance are three major issues facing garnet‐based solid electrolytes. Herein, interfacial architecture engineering by incorporating 1‐butyl‐1‐methylpyrrolidinium bis(trifluoromethylsulfonyl) imide (BMP‐TFSI) ionic liquid into a garnet oxide is proposed. The “soft” continuous BMP‐TFSI coating with no added Li salt generates a conducting network facilitating Li+ transport and thus changes the ion conduction mode from point contacts to face contacts. The compacted microstructure suppresses Li‐dendrite growth and shows good interfacial compatibility and interfacial wettability toward Li metal. Along with a broad electrochemical window larger than 5.5 V and an Li+ transference number that practically reaches unity, LiNi0.8Co0.1Mn0.1O2/Li and LiFePO4/Li solid‐state batteries with the hybrid solid electrolyte exhibit superior cycling stability and low polarization, comparable to those with commercial liquid electrolytes, and excellent rate capability that is better than those of Li‐salt‐based ionic‐liquid electrolytes.
Can synthetic urine replace authentic urine to “beat” workplace drug testing?
Authors: Kim Victor J. , Okano Catherine K. , Osborne Caroline R. , Frank Deanna M. , Meana Christopher T. , Castaneto Marisol S. 
Published: September 2018

AbstractSynthetic urine (SU), which was primarily utilized by drug testing laboratories as a matrix for quality control preparations, is now commercially sold and can be used to “fool” a positive drug test. To determine if SU can pass as authentic urine, we challenged Army urine drug testing specimen accessioning and testing procedures using eight different commercial SU products. Adulteration (Sciteck AdultaCheck® 6) and Onsite SU (Synthetic UrineCheck™) test strips were also evaluated. Five of the eight SU were identified by physical observation. All SU products screened negative in the drug immunoassay and additionally passed the specimen validity testing (SVT) as authentic urine. Furthermore, SU was not detected as adulterated with the adulteration test strips (Sciteck AdultaCheck® 6) but was successfully detected as SU with the On‐site synthetic urine (Synthetic UrineCheck™). To deter SU use, direct observation, as utilized by the military, may be recommended during the collection process.
Software to facilitate and streamline camera trap data management: A review
Authors: Young Stuart , Rode‐Margono Johanna , Amin Rajan 
Published: September 2018

AbstractImproving technology and increasing affordability mean that camera trapping—the use of remotely triggered cameras to photograph wildlife—is becoming an increasingly common tool in the monitoring and conservation of wild populations. Each camera trap study generates a vast amount of data, which need to be processed and labeled before analysis. Traditionally, processing camera trap data has been performed manually by entering data into a spreadsheet. This is time‐consuming, prone to human error, and data management may be inconsistent between projects, hindering collaboration. Recently, several programs have become available to facilitate and quicken data processing. Here, we review available software and assess their ability to better standardize camera trap data management and facilitate data sharing and collaboration. To identify available software for camera trap data management, we used internet searches and contacted researchers and practitioners working on large camera trap projects, as well as software developers. We tested all available programs against a range of software characteristics in addition to their ability to record a suite of important data variables extracted from images. We identified and reviewed 12 available programs for the management of camera trap data. These ranged from simple software assisting with the extraction of metadata from an image, through to comprehensive programs that facilitate data entry and analysis. Many of the programs tested were developed for use on specific studies and so do not cover all possible software or data collection requirements that different projects may have. We highlight the importance of a standardized software solution for camera trap data management. This approach would allow all possible data to be collected, enabling researchers to share data and contribute to other studies, as well as facilitating multi‐project comparisons. By standardizing camera trap data collection and management in this way, future studies would be better placed to guide conservation policy on a global level.
Determination of kinetic parameters of redox reactions using CE‐ICP‐MS: A case study for the reduction of Np(V) by hydroxylamine hydrochloride
Authors: Willberger Christian , Amayri Samer , Reich Tobias 
Published: September 2018

AbstractThe rate constants k of the reduction of 5 × 10–5 M Np(V) to Np(IV) by hydroxylamine hydrochloride (HAHCl) in 1 M HCl have been determined by CE‐ICP‐MS in the temperature range of ϑ = 30–70°C and with varying concentrations of HAHCl from 1 to 7.2 M. The reaction was found to have (pseudo)first order kinetics with respect to HAHCl. The experimental results for k ranged from 0.0029(1) min−1 (ϑ = 40°C, c(HAHCl) = 3 M) to 0.039(7) min−1 (ϑ = 60°C, c(HAHCl) = 7.2 M). The activation energy of the reaction was determined as EA = (72 ± 10) kJ/mol. These results and a comparison with literature data show that the coupling of CE to ICP‐MS provides a powerful analytical tool for the investigation of the kinetic aspects of redox reactions of actinides at low concentrations. On the basis of this proof‐of‐principle study, the method presented here can be extended to the investigation of the kinetic parameters of other redox systems containing different actinides (or transition metals) and oxidants/reductants.
Beach recovery from extreme storm activity during the 2013–14 winter along the Atlantic coast of Europe
Authors: Dodet Guillaume , Castelle Bruno , Masselink Gerd , Scott Timothy , Davidson Mark , Floc'h France , Jackson Derek , Suanez Serge 
Published: September 2018

AbstractThe storm sequence of the 2013–14 winter left many beaches along the Atlantic coast of Europe in their most eroded state for decades. Understanding how beaches recover from such extreme events is essential for coastal managers, especially in light of potential regional increases in storminess due to climate change. Here we analyse a unique dataset of decadal beach morphological changes along the west coast of Europe to investigate the post‐2013–14 winter recovery. We show that the recovery signature is site specific and multi‐annual, with one studied beach fully recovered after 2 years, and the others only partially recovered after 4 years. During the recovery phase, winter waves primarily control the timescales of beach recovery, as energetic winter conditions stall the recovery process whereas moderate winter conditions accelerate it. This inter‐annual variability is well correlated with climate indices. On exposed beaches, an equilibrium model showed significant skill in reproducing the post‐storm recovery and thus can be used to investigate the recovery process in more detail. © 2018 John Wiley & Sons, Ltd.
School gardening increases knowledge of primary school children on edible plants and preference for vegetables
Authors: Leuven Jasper R. F. W. , Rutenfrans Annerie H. M. , Dolfing Alexander G. , Leuven Rob S. E. W. 
Published: September 2018

AbstractAt least 10% of children worldwide are diagnosed with overweight. Part of this problem is attributed to low vegetable intake, for which preference at a younger age is an indicator. Few studies examined long‐term effects of school garden interventions on the knowledge about and preference for vegetables. Therefore, in this study, an intervention period of 7 months (17 lessons) was organized for primary school students (n = 150) of age 10–12 years in the Municipality of Nijmegen (the Netherlands). Surveys were conducted before and after the intervention period to test the ability of students to identify vegetables, to measure their self‐reported preference for vegetables, and to analyze students’ attitudes toward statements about gardening, cooking, and outdoor activity. The long‐term effects were measured by repeating the survey 1 year after the intervention (n = 52). Results were compared with a control group of students (n = 65) with similar background and tested for significance with α = 0.05. School gardening significantly increases the knowledge of primary schoolchildren on 10 vegetables as well as their ability to self‐report preference for the vegetables. The short‐term (n = 106) and long‐term (n = 52) preference for vegetables increased (p < 0.05) in comparison with the control group. The latter did not show a significant learning effect (p > 0.05). This implies that the exposure to vegetables generated by school gardening programs may increase willingness to taste and daily intake of vegetables on the long term. Students’ attitudes toward gardening, cooking, and outdoor activity were unaffected by the intervention.
Differences in use of electronic nicotine delivery systems by smoking status and demographic characteristics among Australian young adults
Authors: Jongenelis Michelle I. , Brennan Emily , Slevin Terry , Kameron Caitlin , Rudaizky Daniel , Pettigrew Simone 
Published: September 2018

AbstractIssue addressedElectronic nicotine delivery systems (ENDS) continue to grow in popularity, particularly among young adults. Understanding by whom various ENDS are being used and why within this population segment can assist the development of appropriate interventions targeting those most vulnerable to use and inform policy decisions in this area. Accordingly, this study assessed the demographic characteristics associated with ENDS use among Australian young adults, and reasons for current e‐cigarette use.MethodsAn online survey was administered to 1116 Australians aged 18‐25 years (59% female).ResultsSmokers were more likely than non‐smokers to report (a) ever use of ENDS (67% vs 28%), (b) ever use of an e‐cigarette (64% vs 24%), e‐cigar (17% vs 8%) or e‐hookah (15% vs 8%) and (c) current use of e‐cigarettes (19% vs 6%). Male smokers were more likely than female smokers to be current e‐cigarette users. The most common reason for current e‐cigarette use was enjoyment.ConclusionsYoung male adults appear to be particularly vulnerable to becoming regular e‐cigarette users. This demographic group may need to be a primary focus of prevention and intervention efforts. Contrary to popular belief, smoking cessation was not a primary reason for e‐cigarette use.So what?Greater efforts are needed to educate young adults on the harms associated with ENDS use, especially if use is being driven by the perception that they are a harmless means of amusement. Maintaining existing regulations limiting the accessibility of these products is crucial to ensuring widespread use is minimised.
Determinants of Female‐Headed Households’ Participation in Periurban Modern Small‐Scale Irrigation Projects in Ethiopia: The Case of Kobo Town
Authors: Sisay Goitom 
Published: September 2018

AbstractOut of the sample of 333 female‐headed households, only 113 (33.9%) participate in irrigation. Hence, this study was intended to identify the determining factors influencing female‐headed households’ participation in periurban modern small‐scale irrigation projects in Kobo town, Ethiopia. To achieve this objective, a cross‐sectional survey method was used on 333 participant and non‐participant households. Descriptive and econometric techniques were employed for data analysis. The binary logit model was used to identify determinants of participation. The chi‐square and t‐test result of this survey shows that participants and non‐participants exhibited a significant variation with regard to age and educational status of the household head, family size, livestock holding, distance to irrigated land, distance to the nearest market centres and access to credit facilities. Furthermore, the binary logit model analysis discloses that educational status of the household head, family size, livestock holding, access to credit services and distance from the nearest market centres have a significant and positive impact on participation. In contrast, age of the household head and distance to irrigated farm are significantly and negatively associated with participation. Hence, for better participation of female‐headed households, development of irrigation projects should take the above‐mentioned determinant variables into account. © 2018 John Wiley & Sons, Ltd.
Front Cover: Dual‐wavelength hybrid optoacoustic‐ultrasound biomicroscopy for functional imaging of large‐scale cerebral vascular networks (J. Biophotonics 9/2018)
Authors: Rebling Johannes , Estrada Héctor , Gottschalk Sven , Sela Gali , Zwack Michael , Wissmeyer Georg , Ntziachristos Vasilis , Razansky Daniel 
Published: September 2018

We present a hybrid dual‐wavelength optoacoustic and ultrasound bio‐microscope capable of rapid transcranial visualization of morphology and oxygenation status of large‐scale cerebral vascular networks. Imaging of entire cortical vasculature in mice is achieved with single capillary resolution and complemented by simultaneously acquired pulse‐echo ultrasound microscopy scans of the mouse skull. The new approach holds potential to facilitate studies into neurological and vascular abnormalities of the brain. Further details can be found in the article by Johannes Rebling, Héctor Estrada, Sven Gottschalk, et al. (e201800057).
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Retracted: miR‐145 eliminates lipopolysaccharides‐induced inflammatory injury in human fibroblast‐like synoviocyte MH7A cells
Authors: Zhong Feng , Xu Jian , Yang Xirui , Zhang Qi , Gao Zhaomeng , Deng Yao , Zhang Lei , Yu Chunyan 
Published: September 2018

AbstractRecently, it has been accepted that miR‐based therapy may be beneficial for rheumatoid arthritis (RA). This study aimed to evaluate the potential involvement of miR‐145 in RA in vitro. The expression of miR‐145 in the human fibroblast‐like synoviocyte line MH7A was overexpressed by miR‐mimic transfection, after which cells were subjected to lipopolysaccharides (LPS). Cell viability, apoptosis, and the release of pro‐inflammatory cytokines were measured. The result showed that the apoptosis and the release of IL‐1β, IL‐6, IL‐8, and TNF‐α were significantly induced by LPS. Meanwhile, LPS treatment led to downregulation of miR‐145. miR‐145 overexpression in LPS‐untreated MH7A cells had no impacts on cell apoptosis and inflammation. But, restoring miR‐145 expression in LPS‐stimulated cells by supplementation of a miR‐145 mimic protected MH7A cells against LPS‐induced apoptosis and inflammation. Furthermore, miR‐145 overexpression in LPS‐untreated MH7A cells slightly blocked the PI3K/ATK and mTOR pathways, whereas miR‐145 overexpression in LPS‐stimulated cells notably repressed the LPS‐induced activation of PI3K/ATK and MAPK/mTOR pathways. Our study suggested that miR‐145 protected MH7A cells against LPS‐induced apoptosis and inflammation by inhibiting the PI3K/AKT and MAPK/mTOR pathways.
Structural insights of resveratrol with its binding partners in the toll‐like receptor 4 pathway
Authors: Saqib Uzma , Faisal Syed M. , Saluja Rohit , Baig Mirza S. 
Published: September 2018

AbstractThe benefits associated with resveratrol (Resv; 3,4′,5‐trihydroxy‐trans‐stilbene) are known for a long time. The therapeutic properties of Resv are observed in diseases like cancer, neurological disorders, atherosclerosis, aging, inflammation, etc. Multiple studies suggest that the beneficial properties of Resv are due to its binding to targets in multiple pathways. The same has been reflected in inflammation, where Resv has been shown to inhibit nuclear factor κ light‐chain enhancer of activated B cells in the toll‐like receptor 4 (TLR4) pathway. There are multiple cellular targets which bind to Resv, however the mode and the key interactions involved remain elusive for many of them. In the current work, we have investigated the structural insights of Resv with three of its binding partners involved in the inflammatory TLR4 signaling pathway. Through a structure‐based modelling and molecular dynamics study, we have unraveled the molecular and atomic interactions involved in the Resv‐binary complexes of inhibitor of κB kinase, cyclooxygeanse‐2, and tank‐binding kinase I, all three of which are key players in TLR4 inflammatory signaling. This study is the latest addition to the investigations of the structural partners of Resv and its molecular interactions.
Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4α
Authors: Guo Shangdong , Lu Hong 
Published: September 2018

AbstractHepatocyte nuclear factor 4α (HNF4α) is a master regulator of development and function of digestive tissues. The HNF4A gene uses two separate promoters P1 and P2, with P1 products predominant in adult liver, whereas P2 products prevalent in fetal liver, pancreas, and liver/colon cancer. To date, the mechanisms for the regulation of
HNF4A and the dynamic switch of P1‐HNF4α and P2‐HNF4α during ontogenesis and carcinogenesis are still obscure. Our study validated the previously reported self‐stimulation of P1‐HNF4α but invalidated the reported synergism between HNF4α and HNF1α.
HNF4A‐AS1, a long noncoding RNA, is localized between the P2 and P1 promoters of
HNF4A. We identified critical roles of P1‐HNF4α in regulating the expression of
HNF4A‐AS1 and its mouse ortholog
Hnf4a‐os. Paired box 6 (PAX6), a master regulator of pancreas development overexpressed in colon cancer, cooperated with HNF1α to induce P2‐HNF4α but antagonized HNF4α in
HNF4A‐AS1 expression. Thus, PAX6 may be important in determining ontogenic and carcinogenic changes of P2‐HNF4α and
HNF4A‐AS1 in the pancreas and intestine. We also interrogated transactivation activities on multiple gene targets by multiple known and novel HNF4α mutants identified in patients with maturity onset diabetes of the young 1 (MODY1) and liver cancer. Particularly, HNF4α‐D78A and HNF4α‐G79S, two mutants found in liver cancer with mutations in DNA‐binding domain, displayed highly gene‐specific transactivation activities. Interestingly, HNF4α‐Q277X, a MODY1 truncation mutant, antagonized the transactivation activities of HNF1α and farnesoid X receptor, key regulators of insulin secretion. Taken together, our study provides novel mechanistic insights regarding the transcriptional regulation and transactivation activity of HNF4α in digestive tissues.