bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terremoto en México: la respuesta en salud del gobierno de la Ciudad de México
Authors: Ahued-Ortega Armando 
Published: March 2018

Ante el evento telúrico del 19 de septiembre de 2017, la Secretaría de Salud de la Ciudad de México (Sedesa) y las instituciones sectorizadas a ella instrumentaron intervenciones en lo inmediato: cada unidad en la red hospitalaria de la Sedesa se preparó para la recepción masiva de pacientes. Se suspendieron las cirugías programadas, se trasladó a los pacientes de urgencias a hospitalización o terapia intensiva y se egresó a aquéllos que pudieran continuar en sus casas, para recibir pacientes con prioridad roja y amarilla. Con la declaratoria de emergencia publicada por el jefe de gobierno la Sedesa, en coordinación con otras dependencias del gobierno de la CDMX, instituciones federales, paraestatales, organizaciones de la sociedad civil e instituciones privadas se instrumentaron los planes, protocolos y acciones definidos exprofeso.
Impacto de los sismos de septiembre de 2017 en la salud mental de la población y acciones recomendadas
Authors: Álvarez-Icaza Dení , Medina-Mora María Elena 
Published: March 2018

Los desastres naturales son un factor de riesgo para el desarrollo de trastornos mentales, por lo que la atención a la salud mental de los afectados es prioritaria. Este texto tiene por objetivo describir la prestación de servicios de salud mental a los afectados por los sismos de septiembre de 2017 y las necesidades de la población. A partir de estas observaciones se concluye que es esencial que el país cuente con un Programa Nacional de Atención a la Salud Mental en Situaciones Críticas y Desastres, cuyas líneas de acción básica se describen en este artículo.
Safe Drilling in Chemically Active and Naturally Fractured Source Rocks: Analytical Solution and Case Study
Authors: Liu Chao , Han Yanhui , Abousleiman Younane 
Published: March 2018

Abstract
The recently formulated theory of dual-porosity dual-permeability porochemoelectroelasticity is applied to derive the analytical solutions for an inclined wellbore drilled through a shale formation, accounting for the effects of natural fractures and shale chemical activity (Liu et al. 2018). With the fully coupling of water, anions, cations flow, stresses, and pore pressure in between shale matrix and fractures, the newly-derived solutions are able to evaluate the relevant stresses and pore pressure around the wellbore.
The analytical solution is applied to study two field cases. The Hoek-Brown failure criterion is employed to evaluate wellbore collapse and mud densities. The two case studies indicate that the analytical solution explains the wellbore failure and is capable of predicting the used safe drilling mudweight. Back analysis on the field data with a sensitivity study is able to estimate the range of the fracture permeability once the matrix permeability is defined.
A comparative study of manhole hydraulics using stereoscopic PIV and different RANS models
Authors: Beg Md Nazmul Azim , Carvalho Rita F. , Tait Simon , Brevis Wernher , Rubinato Matteo , Schellart Alma , Leandro Jorge 
Published: March 2018

Abstract
Flows in manholes are complex and may include swirling and recirculation flow with significant turbulence and vorticity. However, how these complex 3D flow patterns could generate different energy losses and so affect flow quantity in the wider sewer network is unknown. In this work, 2D3C stereo Particle Image Velocimetry measurements are made in a surcharged scaled circular manhole. A computational fluid dynamics (CFD) model in OpenFOAM® with four different Reynolds Averaged Navier Stokes (RANS) turbulence model is constructed using a volume of fluid model, to represent flows in this manhole. Velocity profiles and pressure distributions from the models are compared with the experimental data in view of finding the best modelling approach. It was found among four different RANS models that the re-normalization group (RNG) k-ɛ and k-ω shear stress transport (SST) gave a better approximation for velocity and pressure.
Genetic Variants Involved in Bipolar Disorder, a Rough Road Ahead
Authors: Orrù Germano , Carta Mauro Giovanni 
Published: March 2018

Background:Bipolar Disorder (BD), along with depression and schizophrenia, is one of the most serious mental illnesses, and one of the top 20 causes of severe impairment in everyday life. Recent molecular studies, using both traditional approaches and new procedures such as Whole-Genome Sequencing (WGS), have suggested that genetic factors could significantly contribute to the development of BD, with heritability estimates of up to 85%. However, it is assumed that BD is a multigenic and multifactorial illness with environmental factors that strongly contribute to disease development/progression, which means that progress in genetic knowledge of BD might be difficult to interpret in clinical practice.Objective:The aim of this study is to provide a synthetic description of the main SNPs variants identified/confirmed by recent extensive WGS analysis as well as by reconstruction in anin vitromechanism or by amygdala activation protocolin vivo.Method:Bibliographic data, genomic and protein Data Banks were consulted so as to carry out a cross genomic study for mutations, SNPs and chromosomal alterations described in these studies in BD patients.Results:Fifty-five different mutations have been described in 30 research papers by different genetic analyses including recent WGS analysis. Many of these studies have led to the discovery of the most probable susceptibility genes for BD, including ANK3, CACNA1C, NCAN, ODZ4, SYNE1, and TRANK1. Exploration has started the role of several of these mutations in BD pathophysiology usingin vitroand animal models.Conclusion:Although new genomic research technology in BD opens up new possibilities, the current results for common variants are still controversial because of four broad conditions: analytical validity, clinical validity, clinical utility and a reasonable cost for genetic analysis are not yet accessible.
The Elderly and the City: Lack of Knowledge on Violence Perception and Consequences on Daily Life
Authors: Bramanti Alessia , D’Aloja Ernesto , Cabras Federico , Paribello Pasquale , Moro Maria Francesca , Lindert Jutta , Carta Mauro Giovanni 
Published: March 2018

Introduction:Two main demographic phenomena have substantially changed the condition of elderly: the growth of the urban population and the increase in longevity.Objective:The aim of the present review is to investigate how the elderly living in the cities perceive the sense of insecurity compared to those who reside in rural areas, and their Quality of Life (QoL).Method:Studies published from January 2011 to August 2017 were identified on Google and PubMed combining the following terms: “elderly urban/rural QoL” or “old age urban/rural QoL”.Results:We found 18 different papers published. However, there was only one study on how the elderly perceive the violence in the city. Studies on quality of life were not univocal. Studies on depressive disorders in old age were most homogeneous showing a condition worsening in the cities. A study on the perception of violence in US showed in residents of cities and neighborhoods with the entertainment arena and casinos an increase of criminality perception. In contrast, the crime decreased in both above-mentioned neighborhoods.Conclusion:The condition of elderly in the cities is changed considerably in the recent years. It is estimated that this trend will increase in the coming years. We do not know how older people are experiencing these changes and how they perceive the persistence of violence in the cities. Future researches must satisfy this need by addressing the issue with appropriate methodological tools. This is a public health priority.
Chemical Composition and Antioxidant Potential of Essential Oil and Organic Extracts of Euphorbia tithymaloides L. from Kushtia Region
Authors: Rahman Atiqur , Rahman Mahmudur , Demirtas Ibrahim 
Published: March 2018

Background:
In the traditional system of medicine, leaves and stem bark of Euphorbia tithymaloides
L. have been used for the treatment of asthma, persistent coughing, laryngitis, skin diseases and mouth ulcers.
Some studies have reported the anti-inflammatory and antimicrobial activities of phytochemicals from the leaf;
however, the analysis of essential oil and its antioxidant property is still unexplored.

Methods:
This study evaluates the in vitro antioxidant potential of the essential oil and organic extracts from
aerial parts of Euphorbia tithymaloides L.

Results:
Thirty one compounds representing 96.37% of total oil were detected by GC-MS, of which eugenol
(22.52%), phenyl ethyl alcohol (14.63%), 3-pentanol (9.22%), caryophyllene oxide (7.73%), isoeugenol
(7.32%), pentadecanol (5.14%), spathulenol (5.11%) and α-pinene (3.32%) were the major compounds. The oil
and ethyl acetate extract displayed potent DPPH (IC50 = 13.67 and 17.59 µg/mL, respectively) and superoxide
(IC50 = 21.83 and 42.34 µg/mL, respectively) radical-scavenging activities among all the tested samples. The
oil and methanol extract also exhibited remarkable nitric oxide radical-scavenging activities (IC50 = 90.45 and
112.63 µg/mL, respectively) among other extracts. Furthermore, the methanol extract contained the highest
amount of total phenolics as compared to other samples.

Conclusion:
The results demonstrate that the oil and extracts of E. tithymaloides could serve as natural antioxidants
for using in pharmaceutical or cosmetic industries.
Riluzole Inhibits Proliferation, Migration and Cell Cycle Progression and Induces Apoptosis in Tumor Cells of Various Origins
Authors: Lemieszek Marta Kinga , Stepulak Andrzej , Sawa-Wejksza Katarzyna , Czerwonka Arkadiusz , Ikonomidou Chrysanthy , Rzeski Wojciech 
Published: March 2018

Background:
Regardless of contemporary improvements in cancer treatment, the results of drug
treatment are not always efficacious. Thus, the development of novel approaches that affect cancer cell-specific
metabolic pathways is needed. Since much evidence has shown that tumor cell proliferation and motility are
stimulated by glutamate via activation of its receptors, use of antagonists to these receptors may be the key to
control cancer cell progression. Riluzole noncompetitive metabotropic glutamate receptor 1 (mGluR1) antagonist,
commonly used to treat patients with amyotrophic lateral sclerosis (ALS), has shown some antineoplastic
properties against melanoma, breast and prostate cancer. Yet little is known about its molecular mode of action.

Aims:

The current study aims at evaluating the abilities of Riluzole to inhibit proliferation of several cancer cell
lines, as well as resolve the mechanism of its action.

Method:
We demonstrated antiproliferative and antimigrative properties of Riluzole in rhabdomyosarcomamedulloblastoma,
neuroblastoma, astrocytoma, glioma, colon cancer, lung cancer, thyroid carcinoma, leukemia,
erythroleukemia and multiple myeloma. Our studies revealed apoptosis induction and G2-M cell cycle arrest in
Riluzole treated A549, C6 and HT-29 cells.

Result:

At the molecular level, we found that these cells treated with Riluzole had a decrease of Cyclin B and an
increase of p21 Waf1/Cip1 and p53 expression. We also observed an enhancement of CDK1 and Chk2 phosphorylation.
Reported changes may suggest the involvement of these proteins in G2-M arrest, observed in flow
cytometry analysis. These data indicated the potential use of Riluzole in the treatment of different types of cancers.
Antidiabetic Activities and Identification of Chemical Compound from Samama (<i>Anthocephalus macrophyllus</i> (Roxb) Havil)
Authors: Anisah Laela Nur , Syafii Wasrin , Pari Gustan , Sari Rita Kartika 
Published: March 2018

Samama (Anthocephalus macrophyllus) is one of a pioneer indigenous fast growing species in Indonesia which have been used as traditional medicine for various diseases. The objectives were to determine the yield extract, to analyze their antidiabetic activity by inhibition assay for α-glucosidase enzyme activity and chemical analysis with GCMS. Extraction of leaves, bark and wood samples were done by using ethanol 95%. Fractionation the most active ethanol extract was conducted by using n-hexane and ethyl acetate. The yield of ethanol extracts in leaves, bark and wood were 13.90%, 12.87%, and 2.18% respectively. Based on antidiabetic activity assay, the bark ethanol extract was the most active extract by the IC50 value of 5.86 μg mL-1. Phytochemical analysis on bark ethanol extracts showed that they contained flavonoid, quinon, triterpenoid, saponin and tannin which were assumed have high contribution in antidiabetic activities. The result of fractionation ethanol extract bark showed that the ethyl acetate fraction was the most active fraction (IC50 6.82 μg mL-1). GCMS analysis indicated the presence of dominant phenolic compounds such as pyrocatechol, antiarol, isopropyl myristate and phenol in which were suspected have antidiabetic activity. These results strongly suggested that ethyl acetate fraction of Samama bark was a potential natural source for antidiabetic agents.
Assessing the Spatial-Temporal Land use Change and Encroachment Activities Due to Flood Hazard in North Coast of Central Java, Indonesia
Authors: Hartanto Imam Setyo , Rachmawati Rini 
Published: March 2018

Demak is known as the second largest region suffering land use change in Java’s North Coast. The topographic condition in downstream affects this area becomes susceptible with flood hazard. This research aims to assess the interactions between flooding, land use change and encroachment activities in Mijen and Wedung sub districts, Demak region, Central Java, Indonesia. This research combines the Driving Force, Pressure, State, Impact and Response (DPSIR) analysis. The supervised classification by Maximum Likelihood of time series Landsat images (2000, 2009 and 2014) was chosen for land cover analysis. The land use change shows that paddy field area descended almost 6%, mangrove forest fall 79% meanwhile settlement grown up almost double in 2000-2014. The result of overall accuracy assessment is 78.23%. The DPSIR result shows that land use change not too affect the flood events but floods influence land use pattern in north and south area of Mijen and Wedung. AbstrakDemak merupakan daerah tertinggi kedua yang mengalami perubahan penggunaan lahan di wilayah Pantai Utara Jawa (PANTURA). Kondisi topografinya yang berada di daerah hilir mengakibatkan daerah ini rawan bencana banjir. Penelitian ini bertujuan untuk menganalisa interaksi antara banjir, perubahan penggunaan lahan dan aktivitas yang mengakibatkan perubahan lahan di kecamatan Mijen dan Wedung, Kabupaten Demak, Jawa Tengah-Indonesia. Penelitian ini menerapkan analisis DPSIR (Penyebab Utama, Tekanan, Keadaan, Akibat dan Respon) guna memahami akar permasalahan dan efek berantai dari hubungan tersebut. Klasifikasi terbimbing dengan Maximum Likelihood dari Citra Landsat (2000, 2009 dan 2014) dipilih untuk pemetaan dan analisis tutupan lahan. Hasil perubahan penggunaan lahan menunjukkan bahwa sawah berkurang 6%, hutan mangrove terdegradasi sebanyak 79% sedangkan pemukiman berkembang dua kali lipat selama periode 2000-2014. Hasil analisis akurasi menunjukkan nilai sebesar 78.23 %. Hasil analisis DPSIR menunjukkan bahwa perubahan penggunaan lahan tidak terlalu mempengaruhi kejadian banjir tetapi banjir mempengaruhi pola penggunaan lahan di bagian utara dan selatan wilayah Demak.
Lietuvieši Latvijā Neatkarības kara laikā 1918.–1920. gadā
Authors: Jēkabsons Ēriks 
Published: March 2018

Raksts veltīts nozīmīgas un samērā daudzskaitlīgas Latvijas nacionālās minoritātes – lietuviešu – darbībai Neatkarības kara laikā 1918.–1920. gadā. Apskatītas lietuviešu skaita un sastāva pārmaiņas pēc Pirmā pasaules kara, analizēta lietuviešu nacionāla rakstura darbība politiskajā, sabiedriskajā un kultūras jomā faktiski pilnībā jaunā situācijā – neatkarīgā Latvijas valstī, kā arī lietuviešu piedalīšanās militārajos procesos Latvijā, atrodoties Latvijas armijas rindās un valsts struktūrās. Minētie jautājumi aplūkoti Latvijas un Lietuvas sarežģīto attiecību kontekstā.
Rīgas pilsētas sociālās palīdzības iestādes Maskavas priekšpilsētā 20. gadsimta sākumā
Authors: Lielmane Beāte 
Published: March 2018

Rakstā aplūkotas sociālās palīdzības iestādes Maskavas priekšpilsētā, kuras 20. gadsimta sākumā (līdz Pirmajam pasaules karam) pārraudzīja Rīgas pilsēta. Pēc Rīgas industrializācijas 19. gadsimta otrajā pusē pilsēta saskārās ar jaunām sociālām problēmām, kuras radīja migrācijas izraisītā straujā iedzīvotāju skaita palielināšanās. Iepriekš sociālās palīdzības funkcijas galvenokārt bija vietējo reliģisko un etnisko kopienu rokās, tomēr augstas iedzīvotāju mobilitātes apstākļos ar to vairs nepietika, un pilsētai vajadzēja uzņemties arvien aktīvāku lomu sociālo problēmu risināšanā. Raksta mērķis ir raksturot pilsētas dibinātās un uzturētās sociālās palīdzības iestādes un to ietekmi uz konkrētās Rīgas apkaimes iedzīvotājiem.
Valstspapīru spiestuves izveidošana un pirmie darbības gadi (1919–1921)
Authors: Ančupāne Agita 
Published: March 2018

Pēc Latvijas valsts nodibināšanas Latvijas Pagaidu valdībai bija jārisina vairāki nozīmīgi jautājumi. Viena no būtiskākajām jomām, kas steidzami jāsakārto, bija finanšu sfēra. Latvijas Pagaidu valdībai trūka ne tikai naudas līdzekļu, bet arī dažāda veida vērtspapīru, piemēram, zīmogmarku, pastmarku, bandroļu, obligāciju un tirdzniecības un rūpniecības zīmju, kas bija nepieciešamas veiksmīgai valsts ekonomiskai darbībai. Lai segtu augošo valsts vajadzību pēc vērtspapīriem un naudas zīmēm, Finanšu ministrijas pakļautībā tika nodibināta Valstspapīru spiestuve. Raksta mērķis ir atspoguļot Valstspapīru spiestuves izveidošanas nepieciešamību un ap­stākļus un spiestuves darbības pirmo posmu no izveidošanas līdz 1921. gadam, kad spiestuve tika pārcelta uz jaunām telpām, paverot jaunas attīstības un paplašināšanās iespējas.
Baltijas Universitātes dibināšanas gaita (1945–1946)
Authors: Feldentāle Evita 
Published: March 2018

Rakstā aplūkota Baltijas Universitātes dibināšanas gaita Hamburgā, Vācijā, no 1945. gada vasaras līdz 1946. gada martam un atklāts ceļš no idejas par Hamburgas Universitātes Akadēmiskajiem kursiem līdz Baltijas Universitātes darbības uzsākšanai. Lai gan sākotnēji Universitātes veidošana bija akadēmiski izglītoto latviešu bēgļu plāns, tomēr tā īstenošanā tika iesaistīti arī igauņi un lietuvieši. Secināts, ka idejas attīstība līdz darbības uzsākšanai neaizņēma daudz laika un tās veidotāji saskārās ar finansiālām un materiālām grūtībām. Situācija pēc Otrā pasaules kara bija grūta ne tikai bēgļiem, bet arī pašiem vāciešiem.
SENEGALESES EM RIO GRANDE-RS: DIÁLOGO INTERCULTURAL NO ALÉM MAR
Authors: Pereira Vilmar Alves , Lemos Luciane Oliveira 
Published: March 2018

Esse estudo está associado a alguns movimentos compreensivos que estamos elaborando partindo da compreensão de que a Educação Ambiental enquanto Educação Ambiental Transformadora se afirma se reconhece como práxis social no sentido das possibilidades da busca de uma atuação consciente visando maior sustentabilidade da vida pelo viés crítico. Reconhecendo a presença de imigrantes Senegaleses em Rio Grande num cenário de crise do socioambiental, levantamos a seguinte questão: quais as possibilidades de além de buscarmos reconhecer sua cultura desenvolvermos perspectivas sustentáveis a partir da compreensão de mundo do trabalho que possa apontar para melhores condições desses sujeitos em nossa cidade? O estudo demonstra o grande valor cultural dessa presença em Rio Grande.
A Escola no Contexto do Campo: vivências à partir do Programa Mais Educação
Authors: Souza Vagner Viera de , Miranda Sicero Agostinho , Pereira Elaine Corrêa 
Published: March 2018

Este trabalho é um relato das experiências vivenciadas durante o Projeto Mais Educação numa escola do campo situada na cidade de Rio Grande (RS). As escolas do campo em suas concepções e espaços, devem levar em consideração as especificidades dos sujeitos que vivem no campo. Estes sujeitos, assim como as pessoas que habitam as zonas urbanas, possuem seus códigos e simbologias (cultura), as quais devem ser relacionadas com os temas abordados em sala de aula. Ainda é pertinente destacar a importância de espaços educativos bem planejados para a aprendizagem do homem do campo. Como estratégia que vem à somar no trabalho desenvolvido na escola na perspectiva da educação popular, temos o Programa Mais Educação, instituído através da Portaria Interministerial número 17/2007 e pelo Decreto n° 7.083, de 27 de janeiro de 2010, com intuito de integrar as ações do Plano de Desenvolvimento da Educação (PDE), como uma estratégia do Governo para o incentivo à ampliação do tempo na escola juntamente com a organização curricular, na perspectiva da Educação Integral. O mesmo proporciona aos alunos um contraturno com atividades pedagógicas que agregam diversos conhecimentos e saberes à sua formação.
Relação mulheres e natureza nos interstícios da Educação Ambiental
Authors: Schlee Juliana Corrêa Pereira , Ávila Dárcia Amaro , Henning Paula Corrêa 
Published: March 2018

Como educadoras-pesquisadoras ambientais assumimos um compromisso ético e político, nos provocando a pensar sobre o campo de saber da Educação Ambiental como uma possiblidade de criarmos outras formas de pensar e problematizar verdades e certezas que atravessam a relação das mulheres com a natureza, que tomam como natural na seara da Educação Ambiental. Para alcançar o objetivo proposto nesta pesquisa vamos percorrer alguns acontecimentos discursivos que entrelaçam mulheres e natureza, através das teorizações de Michel Foucault entendemos que os acontecimentos discursivos são eventos importantes, traçados históricos que são tomados como discursos, assim pinçamos da história a Primeira Conferência das Nações Unidas sobre o Meio Ambiente Humano (Estocolmo, 1972); a Conferência Intergovernamental sobre Educação Ambiental (Tbilisi, 1977), que destacam a relação do homem para solução dos problemas ambientais pautados na racionalidade científica e os eventos da Conferência das Nações Unidas sobre Desenvolvimento e Meio Ambiente (Rio de Janeiro, 1992) e a IV Conferência das Nações Unidas sobre a Mulher (Pequim, 1995) que posiciona as mulheres em destaque, convocando-as para proteção e cuidado do planeta. Nessa direção, utilizamos as contribuições de estudos de gênero e meio ambiente a fim de mostrar o quanto estes modos de pensar, valorizar e conceituar a relação mulheres e natureza vem se constituindo e se modificando pela história e cultura. Além disso, visibilizar as aproximações com a educação ambiental nos possibilita problematizarmos e (re)inventarmos novos modos de nos relacionar com a natureza na atualidade.