bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoskopik ultrasonografi yapılan olgularda propofole ketamin veya fentanil ilavesinin sedo-analjezi kalitesi üzerine etkileri
Authors: DAŞKAYA Hayrettin , UYSAL Harun , YILMAZ İNAL Ferda , ESEN Asım , KARAASLAN Kazım 
Published: June 2019

Amaç:Endoskopik ultrasonografi işlemleri genellikle pron
pozisyonunda ve sedo-analjezi altında yapılmaktadır. Bu prospektif çalışmada
tanısal endoskopik ultrasonografi yapılan hastalarda propofol+ketamin ve
propofol+fentanil kombinasyonları ile yapılan sedo-analjezinin etkinliği, hasta
memnuniyeti ve endoskopist memnuniyeti farklılıklarının incelenmesi
amaçlanmaktadır.Gereç-yöntem:&nbsp;Sedo-analjezi ile endoskopik ultrasonografi işlemi
planlanmış 111 hasta çalışmaya dâhil edildi. Tüm hastalara 1mg/kg Lidokain ve
0,01 mg/kg Atropin yapıldıktan sonra Propofol+ketamin grubuna (Grup K) 1,5
mg.kg-1 Propofol, 1 mg.kg-1 Ketamin, Propofol+fentanil
grubuna (Grup F) da 1,5 mg.kg-1 Propofol, 1 mcg. kg-1
Fentanil ile sedo-analjezi sağlandı. Hastaların intraoperatif dönemde Richmond
Ajitasyon Skoru, kalp atım hızı, sistolik-diyastolik-ortalama kan basıncı,
periferik oksijen saturasyonu total işlem süresi ve bu esnada tüketilen toplam
propofol miktarı kaydedildi. Tüm hastalarda Numerik Rank Skoru, vizüel ağrı
skoru ve Aldrete derlenme skoru kaydedildi. İşlem bittikten sonra endoskopistten
ve hastadan memnuniyetini 0-4 arsında puanlandırması istenip kaydedildi.Bulgular:&nbsp;Her iki grupta demografik veriler ve total operasyon
süreleri benzerdi. Toplamda tüketilen tüketilen Propofol düzeyi grup F’de daha
düşüktü (p&lt;0.001). Grup F’de derlenme ünitesinde kalış süresi daha kısa
gözlendi (p&lt;0.001). Endoskopist memnuniyetinde herhangi bir fark
gözlenmezken, hasta memnuniyetinde anlamlı fark tespit edildi (p:001). Grup K’da
İntraoperatif kalp atım hızı ve tansiyon arteriyalde anlamlı artışlar
gözlenirken, grup F’de bu değerler daha stabil seyr etti. Derlenme ünitesi
giriş kalp atım hızları ve tansiyon değerleri grup K’da daha yüksek gözlendi.Sonuç:&nbsp;Endoskopik girişim yapılan hastaların büyük
çoğunluğunun ileri yaş ve ek hastalık mevcudiyeti bulunmaktadır. Bu hastalarda
anestezi ile yapılan işlemlerde anestejik ajan seçimi önem arz etmektedir. Bu
açıdan bakıldığında endoskopik girişimlerde sedo-analjezi uygulanmalarında fentanil
propofol kombinasyonunun avantajlı olduğunu düşünmekteyiz.
The relation of chronic idiopathic urticaria with Fibromyalgia, sleep disturbance and anxiety
Authors: KOCA Tuba Tülay , NAZİK Hülya , MÜLAYİM Mehmet Kamil , ÖZTÜRK Perihan 
Published: June 2019

Aim:
Fibromyalgia syndrome (FMS) and chronic idiopathic urticaria
(CIU) are closely related due to peripheral neurogenic inflammation
(neuropeptide secretion), immune dysfunction, and somatic complaints such as fatigue,
pain, anxiety, and sleep disturbance. This study aimed to reveal the relationship
of CIU with FMS, sleep disturbance and anxiety.Materials
and Methods: A total of 51 patients with CIU aged
18–64 years (36.2±10.4) and 45 sex- and age-matched healthy controls were
included. Urticaria activity score (UAS)
was assessed for the severity of urticaria.&nbsp;
The 2010 American College of Rheumatology classification criteria were
used for FMS diagnosis. The participants were evaluated with visual analog scale (VAS), fibromyalgia impact
questionnaire (FIQ), Pittsburgh sleep quality index (PSQI), and Beck anxiety inventory
(BAI).Results:
The presence of FMS and body mass index
(BMI) were significantly higher in the urticaria group compared with the control
group. The mean FIQ and UAS of the urticaria group were 47.0 ± 22.1 and 1.3 ±
0.9, respectively.&nbsp; UAS was positively
correlated with FIQ, PSQI, BAI and VAS (rho=0.411 p=0.004; rho=0.310 p=0.034;
rho=0.419 p=0.004; rho=0.414 p=0.004; respectively). &nbsp;The presence of FMS was found to be
significantly associated with high BMI (p = 0.04).

Conclusions:
The prevalence of FMS was higher in patients with CIU than control group. Also,
FMS was more severe, general pain and fatigue, sleep disturbance and anxiety
were higher in patients with high urticarial activity.&nbsp;
About nature of the effective surface charge on InAs crystals transformation during anode oxide layer growing
Authors: Artamonov A. V. , Astakhov V. P. , Warlashov I. B. , Gindin P. D. , Evstafieva N. I. , Mitasov P. V. , Miroshnikova I. N. 
Published: June 2019

Dynamics of changes in fluorine atoms distribution through grown anodic oxide layer thickness and the effective surface charge on InAs crystals under such layers has been studied. Anodic oxidation was performed in alkaline electrolyte with fluorochemical additive component in galvanostatic mode at anode current densities 0.05 or 0.5 mA·cm−2. The layers thickness in boundes 32—51 nm varied by electrodes final voltage setting in range 15—25 V. The layer thickness and refractive index was measured by ellipsometric method, and distribution of fluorine atoms through thickness — by photoelectron−spectroscopy method, combined with ion etching. At the same time, based on grown layers there were produced MIS structures, and from calculation of theirs capacitance−voltage characteristics are determined effective surface charge and surface states density, corresponding to different layer thicknesses.Main results are reduced to the facts during layers growing despite of anodizing current density comes their sealing, the profile of fluorine atoms distribution shifts towards InAs, positive effective surface charge gradually decreases from 3.6 · 1011 to 2.0 · 1011 cm−2 at surface states density in (6—7) · 1011 eV·cm−2 range for all cases. Based on comparison of these data and theoretical concepts of MIS structure charge construction, there was made a conclusion about gradual built−in charge distancing from the border with InAs in the process of growing anodic oxide layer, which explains observed effective surface charge decrease during layer thickness increasing. This results indicates that the layer growth rate exceeds the built−in charge displacement rate towards InAs.
PENGARUH PENGGUNAAN ALAT PERMAIANAN EDUKATIF BUSY BOOK TERHADAP PERKEMBANGAN KECERDASAN VISUAL-SPASIAL ANAK
Authors: Annisa R. Maryam Nur , Agustin Mubiar , Eliyawati Cucu 
Published: June 2019

The Influence Of Teaching And Learning Using Busy Book Educative Game On Children’s Visual-Spatial Intelligence. Visual-spatial intelligence is strongly linked to the cognitive aspect, because this intelligence hones thinking ability and concentration. Teaching and learning using busy book educative game stimulates children’s cognitive aspect, enabling them to have optimal activities and curiosity. The aim of this research is to describe the influence of busy book educative games on children’s visual-spatial intelligence. This research employed quasi-experimental design, more precisely Nonequivalent Control Group Design by conducting observation to the control and experimental groups before and after treatment. The data were collected through observation method. The sample consisted of 15 and 13 experimental and control groups, respectively. The calculation of independent t-test results in 0.000, where 0.000 < 0.05, so that Ho is rejected and Ha is accepted. Based on this finding, it is concluded that busy book educative game has influence on the visual-spatial intelligence of children in the orange group of TK Negeri Pembina Cimahi. Pengaruh Penggunaan Alat Permaianan Edukatif Busy Book Terhadap Perkembangan Kecerdasan Visual-Spasial Anak. Kecerdasan visual-spasial erat kaitannya dengan aspek kognitif karena kemampuan yang ada pada kecerdasan visual-spasial ini mengasah kemampuan berfikir dan konsentrasi. Melalui pembelajaran dengan menggunakan Alat Permainan Edukatif busy book ini menstimulasi aspek kognitif anak memungkinkan anak menunjukan aktivitas dan rasa ingin tahu yang optimal. Tujuan dari penelitian ini adalah untuk mendeskripsikan bagaimana pengaruh alat permainan edukatif busy book terhadap kecerdasan visual-spasial anak. Penelitian ini menggunakan desain penelitian Quasi-Experimental jenis Nonequivalent Control Group Design dengan melakukan observasi sebelum perlakuan dan sesudah perlakuan pada kelompok kontrol dan eksperimen. Metode pengumpulan data yang digunakan adalah metode observasi. Sampel pada penelitian ini masing-masing berjumlah 15 anak dari kelompok eksperimen dan 13 anak dari kelompok kontrol. Berdasarkan hasil perhitungan menunjukkan bahwa hasil uji t independen adalah 0,000, yang artinya 0,000 < 0,05, maka Ho ditolak dan Ha diterima. Berdasarkan penelitian tersebut dapat disimpulkan bahwa ada pengaruh Alat Permainan Edukatif (APE) busy book terhadap kecerdasan visual-spasial anak di kelompok jeruk di TK Negeri Pembina Cimahi. Rekomendasi dari penelitian ini adalah guru diharapkan dapat menggunakan alat permainan edukatif busy book untuk menstimulus perkembangan kecerdasan visual-spasial anak.
BRCa1 participates in XIST RNa localization on inactive x chromosome
Authors: Shestakova E. A. , Bogush T. A. 
Published: June 2019

Introduction . Inactive X chromosome (Xi) is associated with noncoding XIST RNA, series of proteins and contains multiple epigenetic modifications that altogether determine a silence of the most of X-linked genes. Recently the data were obtained that tumor suppressor BRCA1 is also associated with Xi. The purpose of this study was to reveal the colocalization of BRCA1 and XIST RNA and precise spatial organization on Xi with the high resolution of confocal microscopy.Materials and methods . The object of the study is IMR90hTERT diploid immortalized fibroblast cell line. For BRCA1 and XIST RNA colocalization analysis on Xi the method of fluorescent hybridization in situ associated with immunofluorescent cell staining (immunoFISH) and confocal microscopy were used. For BRCA1 and heterochromatin protein-1 colocalization study the method of double immunofluorescent staining and common fluorescent microscopy were applied. Results . The study using confocal fluorescent microscopy with higher resolution has demonstrated at first the colocalization of BRCA1 with XIST RNA region of Xi revealed with XIST RNA probes and with replicating Xi and autosomes revealed with BrdU in late S-phase of cell cycle. Altogether, the data obtained suggest the involvement of BRCA1 in the inhibition of gene expression on Xi due to the regulation of XIST RNA association with Xi. Moreover, according to the results of confocal microscopy, BRCA1 also colocalizes with replicating Xi and autosomes revealed with BrdU in late S-phase of cell cycle. This indicates a possible involvement of this protein in the replication of pericentromeric repeats in cellular chromosomes. Colocalization of BRCA1 with heterochromatin protein-1α presented in pericentromeric regions of all chromosomes supports this suggestion.Conclusions . Altogether, the data obtained in this study suggest the involvement of BRCA1 in the inhibition of gene expression on Xi due to the association with noncoding inhibiting XIST RNA and in replication of heterochromatin regions.
Study of antitumor activity of synthetic peptide ryqlhpyr on the prostate cancer cells
Authors: Akentieva N. P. , Shushanov S. S. 
Published: June 2019

Introduction . The RHAMM (hyaluronan mediated mobility receptor) is overexpressed in many types of human cancer and increased synthesis of the RHAMM usually correlates with a poor prognostic factor. In this paper, we synthesized the peptide-RYQLHPYR modulating the activity of the RHAMM and examined the therapeutic potential of this RHAMM-targeting peptide as an antitumor agent.Objective . Study the effect of the synthetic peptide RYQLHPYR on viability, apoptosis, necrosis, caspase-3 / 7 activity, and invasion of prostate cancer cells.Materials and methods . The peptide RYQLHPYR was prepared by solid phase synthesis. Human prostate cancer cells (PC3 m-LN4), murine embryonic fibroblasts and murine embryonic fibroblasts (RHAMM- / -). To quantify the effect of the peptide on apoptosis and cell necrosis, ELISAPLUS was used. The activity of caspase-3 / 7 was determined by the colorimetric method. Evaluation of the anti-metastatic effect of the peptide in vitro was evaluated by invasion of cells by quantitative analysis of the area of degradation of fluorescent gelatin.Results . It was found that the peptide RYQLHPYR inhibited the growth of tumor cells PC3 m-LN4 at a concentration of 10 μg / ml (2 × 10–7 M) after 24 h by ~80 %. It was shown that the peptide stimulated the level of apoptosis in cancer cells, approximately 10-fold. It was found that the peptide increased the necrotic death of tumor cells by 2.5 times. During the research it was revealed that the peptide increased the caspase-3 / 7 activity in tumor cells by 2 times. At the same time, it was shown that RHAMM-targeting peptide had no significant effect on apoptosis and necrosis of normal cells (fibroblasts) and fibroblasts (RHAMM- / -). It was found that the peptide inhibited invasion of tumor cells by ~99.86 % at a concentration of 10 μg / ml (2 × 10–7 M).Conclusions . The obtained results indicate that the peptide RYQLHPYR has antitumor activity and, therefore, has a therapeutic potential for the treatment of prostate cancer.
Un análisis de las representaciones mediáticas y las desigualdades estructurales en el fútbol de mujeres en Argentina
Authors: Moreira Verónica , Litke Martín Álvarez 
Published: June 2019

Este artículo analiza algunos aspectos de la posición subalterna de las atletas argentinas. El caso de las jugadoras que participan en la liga competitiva de la AFA (Asociación de Fútbol Argentino) expone las dificultades que estas deportistas enfrentan a diario cuando quieren desarrollar su práctica. El artículo estudia la relación conflictiva entre las deportistas, las instituciones deportivas y los medios de comunicación; una relación que pone de manifiesto la desigualdad y el trato discriminatorio hacia las futbolistas en dichos ámbitos. Para esto, por un lado, realizamos un diagnóstico de las representaciones de las futbolistas en el diario Olé, medio de comunicación deportivo online que aún publica ejemplares en versión papel; y, por otro lado, analizamos los datos de la observación realizada durante el trabajo de campo en el Club Atlético Boca Juniors, así como también las entrevistas a sus jugadoras y a representantes de otros equipos de la primera división.
Going the Distance: Understanding the Process of Maintaining a Long-Distance Relationship in Graduate School
Authors: Fletcher Emma 
Published: June 2019

Graduate studies can be one of the most stressful periods of an individual’s life, and the added stressor of being at a distance from a significant other (SO) can complicate this issue. The partner is an important source of support and understanding during this process, and they can help alleviate stressors during this transition. Graduate students are typically not the focus of the research, and neither are the positive aspects of engaging in an long-distance relationship (LDR). Thus, this study addresses: What has been the process of maintaining an LDR while entering graduate studies? Participants were selected based on heterogenous and opportunistic sampling, and included four heterosexual, female graduate students whom were engaged in an LDR. Semi-structured interviews were utilized in conjunction with an grounded theory approach to better understand the subjective experiences of initiating, transitioning into, and maintaining an LDR while one partner undertook graduate studies.
Keywords: graduate studies, grounded theory, long-distance relationship, mental health, stress
Discoursing Health Literacies for HIV/AIDS Education
Authors: Oguanobi Hembadoon Iyortyer 
Published: June 2019

Health literacy is an important tool for HIV/AIDS education. It provides a space for students to use local literacy tools such as films, literature, and arts to explore ways of managing the HIV/AIDS virus in communities ravaged by the disease. HIV/AIDS affects the lives of millions of people in many African countries and requires a robust strategy by educators to tackle the epidemic and create safe spaces for students in schools and communities where young people face stigma and discrimination for having the virus, or living with people who have the virus. In this paper, the author discusses how students in some African countries respond to locally manufactured HIV literacy educational tools produced by members of the community. The author makes the case that it is important for schools to incorporate locally manufactured HIV/AIDS health literacy instruction into the curriculum; this would allow young people to engage with health literacies that are resonant of their embodied experiences.
Keywords: Africa, discrimination, health literacies, HIV/AIDS, school programs
Exploring the Stories of Asian-Canadian Women on What It Means to Be Bicultural
Authors: Yeung Betty 
Published: June 2019

Individuals who identify with two cultures, or bicultural individuals, often face unique challenges as they attempt to negotiate the demands of their ethnic and dominant cultures. While much of the research focuses on conceptualizing and measuring bicultural identity, studies investigating the lived experiences of being bicultural are scarce. This study explores the stories of four second-generation Asian-Canadian women about their bicultural experiences and what being bicultural means to them. Drawing from narrative inquiry, interviews were conducted to collect stories from participants. The findings of this study indicate that there are multiple definitions of being bicultural and elucidate some of the challenges faced by second-generation Asian-Canadian women associated with their multifaceted identity. The results provide a better understanding of how Asian-Canadian women define and interact with their bicultural identity.
Keywords: biculturality, culture, ethnies, identity, second-generation
Een bijzondere aankoop voor de KB: Huddes Specilla circularia
Authors: Van Delft Marieke 
Published: June 2019

In this article, the acquisition by the KB | National Library of the Netherlands is discussed of the only known printed copy of the book Specilla circularia, written by Johannes Hudde in 1656. The existence of this small but innovative booklet on the optical properties of telescope lenses was only known from contemporary scholarly correspondence. The content was unknown for a long time, but in 1995 two manuscripts revealing the text of Hudde’s Specilla circularia were discovered and subsequently pub- lished. In 2016 an extremely rare printed copy of Hudde’s booklet surfaced in an auction at the London department of Christies. Research by the auctioneer (and confirmed by other scholars), showed that this copy probably came from the library of Gerard Meerman, auctioned in The Hague in 1824.The extreme rarity of the booklet, its provenance and its contents led to the idea that the KB | National Library of the Netherlands would be the appropriate place for this booklet, written by a Dutch math- ematical heavyweight. After all, the KB houses an important Spinoza collection and a major collection of books written by Hudde’s contemporaties. Thus the KB attempted to acquire the Specilla circulariaand this proved successful: Hudde’s printed leaflet is now one of the highlights of this library.
The Effect of Organizational Resources, Organizational Capabilities, and Learning Orientation on Marketing Mix in Yazd Hospitals
Authors: Vakili Kazem , Neyebzadeh Shahnaz , Yadegariyan Mohammad Ali 
Published: June 2019

Background: The most prominent features of the current world include globalization of the economy, mass production, excess capacity for production lines of the factories and industries in most markets, intensive competition, massive information, and inefficiencies in communications. These all represent formation of the global markets for all national and regional companies, complexity of markets, and the dynamics of this competitive environment. The purpose of this study was to investigate the effect of organizational resources, organizational capabilities, and learning orientation on the marketing mix in hospitals of Yazd.
Methods: This was a descriptive research conducted in 2014. Leonidou et al.'s questionnaire was conducted to study the organizational resources and capabilities. In order to investigate the learning orientation variable, a questionnaire was adopted from a research by Yuan et al. (2013). moreover, to study the marketing mix variable, the questionnaire from the study conducted by Yaghoobi et al. (2011) was adopted. The random sampling method was used and 313 eligible hospital staffs were selected. Data analysis was performed using SPSS18. The relationship between variables and factors were confirmed using confirmatory factor analysis and structural equation modeling techniques using Lisrel 8.72 software.
Results: The first hypothesis revealed a significant relationship between organizational resources and marketing mix, the second hypothesis confirmed a relationship between organizational capabilities and marketing mix, and the third hypothesis showed the effect of learning orientation on the marketing mix, which was confirmed by hypotheses 1 and 3.
Conclusion: Hospital managers should focus on the internal environment of the hospital and identify strengths of the hospital to select the most appropriate strategic options for allocating and distributing resources and capabilities. The potential of human resources, as institutional capital in the health care industry, should be strengthen and developed by managers.
Effect of Aging on Health Expenditure and Gross Domestic Product in Selected Countries by A Dynamic Panel Approach
Authors: Yahyavi Dizaj Jafar , Na'emani Faroogh , Mohammadzadeh Yousef , Irandoust Kamran 
Published: June 2019

Background: An increase in the aging population can affect economic growth and Gross Domestic Product (GDP) by reducing labor supply, reducing productivity, and increasing burden on the population. The current study aimed to explain the economic effects of aging and examined the relationship between aging, health expenditure, and GDP.
Methods: This descriptive-analytical study was conducted using the data of global development indicators, published by World Bank for the selected countries from 1996 to 2017. The study population included 40 selected countries with moderate to high income. The data related to each country were extracted. Later, the dynamic panel data approach and generalized method of moments (GMM) were applied to analyze the information. Furthermore, the generalized method of moments regression was also used by Stata 14.
Results: The findings showed that aging had a negative and significant effect on GDP, so that increase of 1.00 % in the elderly population decreased the GDP growth by 2.14 %. Furthermore, countries' investment in the health sector had a positive and significant effect on the GDP. In this regard, an increase of 1.00 % in health and treatment costs improved the GPD by 0.03 %. Multiplication of aging in health expenditure and inflation index had a significant negative impact on the growth of GDP per capita.
Conclusion: The results of this study showed that population aging reduced GDP by absorbing a part of the health expenditure. Therefore, in order to reduce the negative effects of this phenomenon, a long-term approach to budgeting is required to strengthen and support the pension fund, plan more comprehensive health insurance coverage for the elderly, and develop related institutions.