bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of mathematical models for predicting medicine distribution into breastmilk - considering biological heterogeneity
Authors: Heo Sumin , Butler Andrew S. , Stamouli Simoncioni Marina , Moult Sam , Malamatari Maria , Kerwash Essam , Cole Susan 
Published: November 2024

IntroductionA significant proportion of mothers take medication during the breastfeeding period, however knowledge of infant safety during continued breastfeeding is often limited. Breastmilk exhibits significant physiological heterogeneity, with a range of milk fat (creamatocrit), protein and pH values available within the literature. Mathematical models for the prediction of infant exposure are available and these predict that variable milk physiology will significantly affect accumulation of drugs within the breastmilk. These models are typically validated against limited datasets only, and to the best of our knowledge no widescale review has been conducted which accounts for the heterogeneity of breastmilk.MethodsObserved area under the curve milk-to-plasma (M/P) ratios and physicochemical properties were collected for a diverse range of drugs. The reliability of previously published mathematical models was assessed by varying milk pH and creamatocrit across the physiological range. Subsequently, alternative methods for predicting lipid and protein binding within the milk, and the effect of ionisation and physicochemical properties were investigated.ResultsExisting models mis-predicted &gt;40% of medications (Phase Distribution model), exhibited extreme sensitivity to milk pH (Log-Transformed model) or exhibited limited sensitivity to changes in creamatocrit (LogPo:w model). Alternative methods of predicting distribution into milk lipids moderately improved predictions, however altering the way in which milk protein binding was predicted and the effect of ionisation on this demonstrated little effect. Many drugs were predicted to have a significant range of M/P ratios.DiscussionThese data show that consideration of the biological heterogeneity of breastmilk is important for model development and highlight that increased understanding of the physiological mechanisms underlying distribution within the milk may be essential to continue improving in silico methodologies to support infant and maternal health.
Genetic analysis of grain yield and related traits of extra-early orange maize inbred lines and their hybrids under drought and rain-fed conditions
Authors: Bonkoungou Tégawendé Odette , Badu-Apraku Baffour , Adetimirin Victor Olawale , Nanema Kiswendsida Romaric , Adejumobi Idris Ishola 
Published: November 2024

BackgroundOrange maize genotypes are sources of provitamin A (PVA) carotenoids, which are precursors of vitamin A. PVA deficiency and drought constitute major challenges causing increasing food and nutritional insecurity in sub-Saharan Africa (SSA). Breeding of drought-tolerant provitamin A hybrid maize can mitigate these challenges. This study was undertaken to determine the combining ability of newly developed extra-early orange inbreds for grain yield and related traits under managed drought stress and rain-fed conditions, determine the mode of gene action conditioning the inheritance of the traits, and classify the inbreds into heterotic groups.MethodologyOne hundred and ninety-six extra-early orange hybrids comprising 180 testcrosses, 10 single crosses, and 6 commercial checks were evaluated under managed drought and rain-fed conditions at Ikenne. In addition, 41 inbreds comprising 36 orange lines and 5 PVA testers involved in the hybrid development were assessed under drought and rain-fed conditions.ResultsThe means square for general combining ability (GCA) and specific combining ability (SCA) were significant for grain yield and most other traits under both growing conditions. The contributions of GCA to performance were larger than SCA in each growing condition. Broad-sense and narrow-sense heritability estimates for grain yield were 66% and 37% under managed drought and 88% and 32% under rain-fed conditions, respectively. Mid-parent heterosis and better-parent heterosis for grain yield were 338% and 247% under managed drought, while 173% and 137% under rain-fed conditions. Significant positive correlations existed among grain yield of hybrids, heterosis, and specific combining ability under managed drought. The 41 inbred lines were classified into three heterotic groups under both growing conditions. Sixteen testcross hybrids out-yielded the best commercial check under managed drought.ConclusionThe testcross hybrids have great potential for commercialization to address the problem of drought and PVA deficiency in SSA. Inbred TZEEIOR 510 showed desirable GCA effects for grain yield and 04 other traits under drought.
The impact of maternal emotional warmth on adolescents’ internalizing problem behaviors: the roles of meaning in life and friendship conflict
Authors: Zhang Ludan , Wang Ruijie , Li Yaoyao , Chen Liang 
Published: November 2024

IntroductionNumerous studies suggest that maternal emotional warmth is a critical protective factor against adolescents’ internalizing problem behaviors. However, the underlying mechanisms linking these variables remain unclear. Grounded in ecological systems theory, this study explores the impact mechanisms of social support (maternal emotional warmth), individual resource (meaning in life), and environmental factor (friendship conflict) on adolescents’ internalizing problem behaviors.MethodsA questionnaire survey of 474 adolescents in vocational school aged 15–24 assessed maternal emotional warmth, meaning in life, friendship conflict, and internalizing problem behaviors.ResultsThe results indicate that the meaning in life partially mediates the relationship between maternal emotional warmth and adolescents’ internalizing problem behaviors, with friendship conflict moderating the latter half of this mediation pathway.DiscussionThe findings suggest that adolescents, during their social adaptation process, activate different protective factors depending on the environmental relational context. Specifically, high friendship conflict limits the direct protective role of maternal emotional warmth, whereas a meaning in life becomes a significant protective factor, exerting its effect through mediation. Conversely, when friendship conflict is low, maternal emotional warmth directly serves as a protective factor.
Narration of a collective traumatic event according to the presence of PTSD and considering the social function
Authors: Charretier Laura , Eustache Francis , Laisney Mickael , Dayan Jacques , Fraisse Florence , de La Sayette Vincent , Gagnepain Pierre , Chakli Amine , Klein-Peschanski Carine , Peschanski Denis , Quinette Peggy 
Published: November 2024

IntroductionIndividuals suffering from PTSD recount the traumatic event using perceptual, emotional and sensory details. Memorization and recall of individual events are influenced by the individual’s social function, i.e., what they are willing and able to share about themselves with others and the society. While the influence of PTSD on narratives has been studied, few studies have measured the effect of social function on the link between PTSD and narrative.ObjectivesThe aim was to measure trauma narratives of the terrorist attacks of November 13, 2015, according to the presence of PTSD and considering the social function (civil or professional) at the time of exposure.MethodsThirty-seven civilians (including 16 women and 21 men) and 22 first responders (including 7 women and 15 men) exposed to the terrorist attacks of November 13, 2015, in France recounted their experiences. Textometric analyses were carried out to characterize the narrative lexicons of the 4 groups (civilians with PTSD; civilians without PTSD, first responders with PTSD; first responders without PTSD).ResultsThe narratives of civilians with or without PTSD contain emotional details of the event. The narratives of first responders with and without PTSD contain details of intervention and team. The narratives of civilians and first responders with PTSD contain elements of social and family contacts. The narratives of civilians and first responders without PTSD contains elements of collective control and aid. Civilians with PTSD mostly use the “I” in narratives, while first responders without PTSD mostly use the “we” narrative and the notion of colleague.ConclusionTrauma narratives of individuals exposed to the same collective traumatic event who have developed PTSD are characterized by information about social and family contexts. Trauma narratives of individuals without PTSD show a sense of control and collective support. Associated with PTSD, the social function during the event influences the narrative, involving self-centered statements (first person singular, individual reactions) for exposed civilians, and allo-centered statements (colleagues, victims) for exposed professionals. This study underlines the importance of considering the inclusion of reference to the social group to which one belongs when testifying about peritraumatic experiences to others.
Big-five personality traits and depression: chain mediation of self-efficacy and walking
Authors: Cai Han , Song Hongtao , Yang Yating , Xiao Zihe , Zhang Xianlong , Jiang Feng , Liu Huanzhong , Tang Yi-lang 
Published: November 2024

BackgroundDepression is a major global public health concern, with research indicating a correlation between personality traits and depression. This study aimed to explore the potential mediating roles of self-efficacy and walking in the relationship between personality traits and depression among Chinese residents.MethodsA cross-sectional questionnaire survey was conducted from July 10 to September 15, 2021, involving 11,031 Chinese residents across 23 provinces, 5 autonomous regions, and 4 municipalities Participants provided data on demographics, personality traits (using the Ten-Item Personality Inventory), self-efficacy (using the New General Self-Efficacy Scale), chronic disease self-management (using the Chronic Disease Self-Management Study Measures), and depression (using the Patient Health Questionnaire-9). After screening, data from 8,499 participants were analyzed. Sequential mediation models were employed, with the Big Five personality traits as predictors, depression as the outcome, and self-efficacy and walking as the mediators.ResultsExtraversion, agreeableness, conscientiousness, and emotional stability were negatively correlated with depression, with self-efficacy and walking as positive mediators in these relationships. Conversely, openness was positively associated with depression, and the self-efficacy-walking chain did not mediate this relationship but rather masked the effect of openness on depression.ConclusionsOur findings suggest that self-efficacy and walking are significant mediators in the relationship between personality traits and depression, potentially mitigating the risk of depressive episodes.
Feasibility and acceptability of wearing a neuromodulation device at night in individuals in recovery from opioid use disorder
Authors: Meads Kristy L. , Huettner Steve , Amata Dexter , Johnson Hailey , Devine Jaime K. , Warnakulasuriya Shenali , Murphy Keith R. , Good Cameron H. 
Published: November 2024

IntroductionOpioid use disorder (OUD) is a serious and persistent problem in the United States with limited non-pharmacological treatment options, especially for the concomitant sleep disorders experienced by most individuals with addiction. While new, non-invasive interventions such as low-intensity focused ultrasound (LIFU) have shown promise in targeting the brain regions impacted throughout addiction and recovery, the devices used are not amenable to outpatient treatment in their current form factor and cannot be used at night during sleep. To bridge this gap and provide a much-needed treatment option for repeated, at-home use, we developed a wearable LIFU device out-of-clinic use.MethodsThis study evaluated the feasibility and acceptability of the portable treatment device among individuals recovering from OUD in an unsupervised, at-home setting. 31 subjects were recruited from a Baltimore, Maryland (USA) outpatient treatment facility and, along with a separate group of 14 healthy controls (HC), were asked to wear a prototype EEG-only (non-LIFU) device for 7 consecutive nights to assess their willingness and adherence to nightly use. Participants used a smartphone application, TrialKit (ePRO), to self-report nightly sleep data (e.g. duration, quality, possible disturbances, and device comfort).ResultsOf the 31 OUD participants recruited, 30 (97%) successfully completed the at-home study, and the majority responded that they would participate in future studies using the head wearable device (OUD, 87%; HC, 71%). OUD participants were statistically more likely than HCs to respond that they would consider using the device in the future to help them sleep (OUD, 70%; HC, 29%). Despite some participants facing technological issues (e.g. lack of reliable phone access or cellular data plans), the OUD group demonstrated high study compliance on par with the healthy control group.DiscussionParticipant’s daily ePRO and exit interview results established that at-home use of advanced treatment technology is feasible in a population group challenged with recovering from OUD. Even more so, numerous participants noted strong willingness to participate in future LIFU-enabled intervention studies to address their persistent sleep issues during recovery.
Plastic waste characterisation to maximise landfill diversion from a New Zealand residential construction site
Authors: Low Joanne K. , Hernandez German , Berry Terri-Ann 
Published: November 2024

IntroductionIn New Zealand, the construction sector is responsible for a large proportion of waste sent to landfill. The plastic profile of construction waste is varied and complex in comparison to other waste types (e.g. timber, concrete, metals, plasterboard). Therefore, the diversion of plastics from landfills is less straightforward, and there are less obvious benefits to recycling this low-density, low-value waste stream. Plastic waste generated by construction activities has not been well-characterised, which has affected opportunities for waste reduction, reuse and recycling. To fill this knowledge gap, this study characterised the plastic waste generated from a residential construction site. This was used to identify opportunities to address the full waste hierarchy through reduction, reuse and recycling and ultimately enable more sustainable plastic waste management.MethodsPlastic waste generated from a construction site in Auckland, New Zealand (construction of eight terraced houses) was separated during the project into several categories (pipes, soft plastics, other plastics and hazardous waste). This was followed by in-depth auditing which further sorted waste types by main composition, followed by analysis for polymer type using fourier-transform infrared spectroscopy (FTIR). The research was phased to determine the plastic waste generated across each of the main construction stages. Once the main polymer types had been identified, local waste providers were contacted to establish opportunities for reuse or recycling.ResultsThe total mass of plastics generated from all construction stages was 725 kg, 66.4% (by wt.) of which was recycled. Soft plastics, predominantly low-density polyethylene, were the most common plastic type; this was followed by pipes and expanded polystyrene. Plastic packaging, primarily soft plastics and polystyrene, accounted for 60% of total plastics and were mostly generated in the final stages of construction (i.e. fittings and fit-out). This characterisation of construction plastic waste can be used to demonstrate the feasibility of sustainable plastic waste management in Auckland and to identify construction plastic waste sources on an international scale. More studies on a variety of construction types (e.g. detached residential, apartment blocks, commercial) are required to address the full breadth of plastic materials used and to drive a more circular economy for this potential resource.
EEG oscillatory signatures of increased cognitive control at intersections: a virtual reality driving simulation
Authors: Senftleben Ulrike , Kessler Klaus 
Published: November 2024

IntroductionIntersections are particularly complex traffic situations and are often the scene of accidents. Driver behaviour and decision-making might be affected by specific factors such as the right of way, traffic volume, and the occurrence of a critical event directly before the intersection.MethodsWe developed a new driving scenario in virtual reality (VR) to test the impact of these factors using a fully immersive head-mounted display. Participants had to navigate through a series of intersections to reach their target destination. We recorded their driving behaviour as well as their brain activity using electroencephalography (EEG).ResultsOur results showed that participants engaged cognitive control processes when approaching an intersection with high traffic volume and when reacting to a critical event, as indexed by driving behaviour and proactively by increased theta power. We did not find differences for right of way in the EEG data, but driving behaviour was as expected, revealing a driving speed reduction when participants had to yield to traffic.DiscussionWe discuss advantages and potential challenges of an immersive VR-based approach to driving simulations and the challenges encountered when recording and analysing EEG data. We conclude that despite movement and electronic artefacts, EEG data in the theta and alpha bands can be analysed robustly and allow for novel insights into control processes in realistic VR scenarios.
Evaluation and spatiotemporal evolution of veterinary talent competitiveness: a new perspective of veterinary education
Authors: Xu Xianhang , Arshad Mohd Anuar , Jian Yugang , Mahmood Arshad , Dong Mengdie 
Published: November 2024

IntroductionImproving the quantity and quality of veterinary talent cultivation is an urgent issue to address in current veterinary education and is key to enhancing veterinary talent competitiveness. Starting from an industrial perspective, the introduction of scientific analytical methods for studying veterinary talent competitiveness offers a new view on veterinary education and helps to improve the quality of veterinary education and talent cultivation.MethodsThis study develops a veterinary talent competitiveness evaluation index based on the characteristics of veterinary talent. It proposes a visual method to analyze the level and spatiotemporal evolution of veterinary talent competitiveness using the Entropy method and ArcGIS tools, with Western China as a case study. Data is collected from 12 regions in Western China, spanning 2015 to 2021.ResultsThe results show that the method not only evaluates the current state of veterinary talent competitiveness but also considers temporal and spatial evolution, achieving good evaluation effectiveness and high accuracy, thereby guiding the improvement of veterinary education and talent cultivation.DiscussionBased on the research findings, the study suggests improving the quality of veterinary education and talent cultivation through measures such as strengthening talent resource development, addressing regional imbalances, and promoting spatial integration to achieve a virtuous cycle between veterinary education and industrial development.
Microbial Communities in and Around the Siboglinid Tubeworms from the South Yungan East Ridge Cold Seep Offshore Southwestern Taiwan at the Northern South China Sea
Authors: Li Yin , Ye Zhiwei , Lai Mei-Chin , Liu Char-Shine , Paull Charles K. , Lin Saulwood , Lai Shu-Jung , You Yi-Ting , Wu Sue-Yao , Hung Chuan-Chuan , Ding Jiun-Yan , Shih Chao-Jen , Wu Yen-Chi , Zhao Jingjing , Xiao Wangchuan , Wu Chih-Hung , Dong Guowen , Zhang Hangying , Qiu Wanling , Wang Song , Chen Sheng-Chung 
Published: November 2024

To date, only a few microbial community studies of cold seeps at the South China Sea (SCS) have been reported. The cold seep dominated by tubeworms was discovered at South Yungan East Ridge (SYER) offshore southwestern Taiwan by miniROV. The tubeworms were identified and proposed as Paraescarpia formosa sp. nov. through morphological and phylogenetic analyses. The endosymbionts in the trunk of P. formosa analyzed by a 16S rRNA gene clone library represented only one phylotype, which belonged to the family Sedimenticolaceae in Gammaproteobacteria. In addition, the archaeal and bacterial communities in the habitat of tubeworm P. formosa were investigated by using high-phylogenetic-resolution full-length 16S rRNA gene amplicon sequencing. The results showed that anerobic methane-oxidizing archaea (ANME)-1b was most abundant and ANME-2ab was minor in a consortia of the anerobic oxidation of methane (AOM). The known sulfate-reducing bacteria (SRB) partners in AOM consortia, such as SEEP-SRB1, -SRB2, and -SRB4, Desulfococcus and Desulfobulbus, occurred in a small population (0–5.7%) at the SYER cold seep, and it was suggested that ANME-1b and ANME-2ab might be coupled with multiple SRB in AOM consortia. Besides AOM consortia, various methanogenic archaea, including Bathyarchaeota (Subgroup-8), Methanocellales, Methanomicrobiales, Methanosarcinales, Methanofastidiosales and Methanomassiliicoccales, were identified, and sulfur-oxidizing bacteria Sulfurovum and Sulfurimonas in phylum Epsilonbacteraeota were dominant. This study revealed the first investigation of microbiota in and around tubeworm P. formosa discovered at the SYER cold seep offshore southwestern Taiwan. We could gain insights into the chemosynthetic communities in the deep sea, especially regarding the cold seep ecosystems at the SCS.