bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equality, Liberty and the Limits of Person-centred Care’s Principle of Co-production
Authors: Badano Gabriele 
Published: September 2018

AbstractThe idea that healthcare should become more person-centred is extremely influential. By using recent English policy developments as a case study, this article aims to critically analyse an important element of person-centred care, namely, the belief that to treat patients as persons is to think that care should be ‘co-produced’ by formal healthcare providers and patients together with unpaid carers and voluntary organizations. I draw on insights from political philosophy to highlight overlooked tensions between co-production and values like equality and liberty. Regarding equality, I argue that co-production compounds both problems of gender inequality in the distribution of care labour and the challenges associated with securing equal access to care. Turning to liberty, I identify important commonalities between co-production and republicanism in political philosophy, given their shared insistence on common citizens’ civic virtue. Then, I use against co-production some liberal arguments against republicanism, to highlight a problem of over-demandingness. In bringing my argument to a close, however, I wish to caution against hastily rejecting co-production as a policy programme.
Stability for hyperplane complements of type B/C and statistics on squarefree polynomials over finite fields
Authors: Jiménez Rolland Rita , Wilson Jennifer C H 
Published: September 2018

AbstractIn this paper, we explore a relationship between the topology of the complex hyperplane complements ℳBCn(ℂ) in type B/C and the combinatorics of certain spaces of degree-n polynomials over a finite field Fq. This relationship is a consequence of the Grothendieck trace formula and work of Lehrer and Kim. We use it to prove a correspondence between a representation-theoretic convergence result on the cohomology algebras H*(ℳBCn(ℂ);ℂ), and an asymptotic stability result for certain polynomial statistics on monic squarefree polynomials over Fq with non-zero constant term. This result is the type B/C analogue of a theorem due to Church, Ellenberg, and Farb in type A, and we include a new proof of their theorem. To establish these convergence results, we realize the sequences of cohomology algebras of the hyperplane complements as FIW-algebras finitely generated inFIW-degree 2, and we investigate the asymptotic behaviour of general families of algebras with this structure. We prove a negative result implying that this structure alone is not sufficient to prove the necessary convergence conditions. Our proof of convergence for the cohomology algebras involves the combinatorics of their relators.
Parametrized monomial surfaces in 4-space
Authors: Rodrigues Hernandes M E , Ruas M A S 
Published: September 2018

Abstract
In this work, we classify parametrized monomial surfaces f:(ℂ2,0)→(ℂ4,0) that are A-finitely determined. We study invariants that can be obtained in terms of invariants of a parametrized curve.
On locally repeated values of arithmetic functions over Fq[T]
Authors: Rudnick Zeév , Peled Ron 
Published: September 2018

AbstractThe frequency of occurrence of ‘locally repeated’ values of arithmetic functions is a common theme in analytic number theory, for instance in the Erdős–Mirsky problem on coincidences of the divisor function at consecutive integers, the analogous problem for the Euler totient function and the quantitative conjectures of Erdős, Pomerance and Sarkőzy and of Graham, Holt and Pomerance on the frequency of occurrences. In this paper, we introduce the corresponding problems in the setting of polynomials over a finite field, and completely solve them in the large finite field limit.
Nocturnal scent in a ‘bird-fig’: a cue to attract bats as additional dispersers?
Authors: Ripperger Simon P. , Rehse Saskia , Wacker Stefanie , Kalko Elisabeth K. V. , Schulz Stefan , Rodriguez-Herrera Bernal , Ayasse Manfred 
Published: September 2018

AbstractThe plant genus Ficus is a keystone resource in tropical ecoystems. One of the unique features of figs is the diversity of fruit traits, which in many cases match their various dispersers, the so-called fruit syndromes. The classic example of this is the strong phenotypic differences found between figs with bat and bird dispersers (color, size, and presentation). The ‘bird-fig’ Ficus colubrinae represents an exception to this trend since it attracts the small frugivorous bat species Ectophylla alba at night, but during the day attracts bird visitors. Here we investigate the mechanism by which this ‘bird-fig’ attracts bats despite its fruit traits, which should appeal solely to birds. We performed feeding experiments with Ectophylla alba to assess the role of fruit scent in the detection of ripe fruits. Ectophylla alba was capable of finding ripe figs by scent alone under exclusion of other sensory cues. This suggests that scent is the main foraging cue for Ectophylla alba. Analyses of odor bouquets from the bat- and bird-dispersal phases (i.e. day and night) differed significantly in their composition of volatiles. The combination of these two findings raises the question whether E. alba and F. colubrinae resemble a co-adaptation that enables a phenotypically classic ‘bird-fig’ to attract bat dispersers by an olfactory signal at night thus maximizing dispersal.
Deciphering defective subventricular adult neurogenesis in cyclin D2-deficient mice
Authors: Płatek Rafał , Kaczmarek Leszek , Czupryn Artur 
Published: September 2018

ABSTRACTAdult neurogenesis occurring in the brain of adult mammals is considered to have potential therapeutical applications. New neurons are produced constitutively from postnatal neural stem cells/precursors residing in two neurogenic regions: the subventricular zone (SVZ) of the lateral ventricles and the subgranular layer in the dentate gyrus of the hippocampus. Newly-generated neuroblasts from the SVZ migrate long distance towards the olfactory bulb and repopulate different subtypes of inhibitory interneurons modulating the olfactory processing. It was reported that cyclin D2 knockout mice (cD2-KO) present reduced generation of new hippocampal neurons, however proliferation deficiency and mechanisms responsible for dysregulation of subventricular precursors, derived progenitors, and olfactory interneurons need to be detaily investigated. In this report, proliferative activity of different subpopulations of SVZ neural precursors, cell migration, and differentiation in cD2-KO mice was characterized. For that goal, EdU, a thymidine analogue, proliferation mapping combined with multi-epitope immunohisto-chemical detection of endogenous stage-specific cell markers was carried out. Severely reduced number of newly-generated cells in the subventricular niche was demonstrated that was not accompanied by increased level of apoptotic death. Surprisingly, the number of B1 quiescent precursor subpopulation was not affected, whereas the number of B1 type active primary precursors, intermediate/transiently-amplifying progenitors (C type cells), and neuroblasts (A type cells) were reduced. The analyses suggest that cycline D2 might be critical for transition of B1 precursor quiescent cells into B1 active cells. We also demonstrate that the subpopulation of calbindin interneurons is reduced in the olfactory bulb. Deciphering processes underlying a potential modulation of intensity of adult neurogenesis at the cellular levels could lead to replacement therapies after injury, stroke, or neurodegenerative disease in the central nervous system.
Mutual transcriptional repression betweenGli3andHox13genes determines the anterior-posterior asymmetry of the autopod
Authors: Bastida Ma Félix , Pérez-Gómez Rocío , Trofka Anna , Sheth Rushikesh , Stadler H. Scott , Mackem Susan , Ros Marian A. 
Published: September 2018

ABSTRACTIn the present study we have investigated the molecular causes of the absence of digit 1 in theHoxa13mutant and why the absence of Hoxa13 protein, whose expression spans the entire autopod, specifically impacts the anterior-most digit. We show that in the absence ofHoxa13, the expression ofHoxd13does not extend into the anterior mesoderm consequently leaving the presumptive territory of digit1 devoid of distalHoxexpression and providing an explanation for the agenesis of digit 1. We provide compelling evidence that the lack ofHoxd13transcription in the anterior mesoderm is due to increased Gli3R activity, in turn resulting from the loss of transcriptional repression exerted by Hoxa13 onGli3. Our results are compatible with a mutual transcriptional repression betweenGli3andHox13genes that determines the anterior-posterior asymmetry of the autopod.
Apical caspase reporters uncover unknown stages of apoptosis and enable ready visualization of undead cells
Authors: Baena-Lopez Luis Alberto , Arthurton Lewis , Bischoff Marcus , Vincent Jean-Paul , Alexandre Cyrille , McGregor Reuben 
Published: September 2018

AbstractThe caspase-mediated regulation of many cellular processes, including apoptosis, justifies the substantial interest in understanding all of the biological features of these enzymes. To complement functional assays, it is critical to identify caspase-activating cells in live tissues. Our work describes new caspase-reporters that, for the first time, provide direct information concerning the initial steps of the caspase activation cascade in Drosophila tissues. One of our caspase-sensors has capitalized on the rapid subcellular localization change of a fluorescent marker to uncover novel cellular apoptotic events. These refer to the actin-mediated positioning of the nucleus before cell delamination. The other construct has benefited from a caspase-induced nuclear translocation of a QF transcription factor. This feature enables the genetic manipulation of caspase-activating cells, whilst showing the spatio-temporal patterns of apical caspase activation. Collectively, our sensors offer new experimental opportunities that are already illuminating unknown aspects of caspase-dependent processes in apoptotic and non-apoptotic cellular scenarios.Summary statementWe describe a novel set of caspase sensors that directly detect early caspase activation. The exclusive features of our reporters uncovered unknown stages of apoptosis and properties of caspase-activating cells.
Parcellation of motor sequence representations in the human neocortex
Authors: Yokoi Atsushi , Diedrichsen Jörn 
Published: September 2018

AbstractWhile previous studies have revealed an extended network of cortical regions associated with motor sequence production, the specific role of each of these areas is still elusive. To address this issue, we designed a novel behavioural paradigm that allowed us to experimentally manipulate the structure of motor sequences representations in individual participants. We then conducted fMRI while participants executed 8 trained sequences to examine how this structure is reflected in the associated activity patterns. Both model-based and model-free approaches revealed a clear distinction between primary and non-primary motor cortices in their representational contents, with M1 specifically representing individual finger movements, and premotor and parietal cortices showing a mixture of chunk, sequence and finger transition representations. Using model-free representational parcellation, we could divide these non-primary motor cortices into separate clusters, each with a unique representation along the stimulus-to-action gradient. These results provide new insights into how human neocortex organizes movement sequences.
Separate lanes for math and reading in the white matter highways of the human brain
Authors: Grotheer Mareike , Zhen Zonglei , Lerma-Usabiaga Garikoitz , Grill-Spector Kalanit 
Published: September 2018

AbstractMath and reading involve distributed brain networks and have both shared (e.g. encoding of visual stimuli) and dissociated (e.g. quantity processing) cognitive components. To date, it is unknown what are shared vs. dissociated gray and white matter substrates of the math and reading networks. Here we address this question using an innovative, multimodal approach applying functional MRI, diffusion MRI, and quantitative MRI to define these networks and evaluate the structural properties of their fascicles. Results reveal that i) there are distinct gray matter regions which are preferentially engaged in either math or reading and ii) the superior longitudinal (SLF) and arcuate (AF) fascicles are shared across math and reading networks. Strikingly, within these fascicles, reading- and math-related tracts are segregated into parallel sub-bundles and show structural differences related to myelination. These novel findings open a new avenue of research that examines the contribution of sub-bundles within fascicles to specific behaviors.
Optimization of Dose Schedules for Chemotherapy of Early Colon Cancer Determined by High Performance Computer Simulations
Authors: Cockrell Chase , Axelrod David E. 
Published: September 2018

AbstractCancer chemotherapy dose schedules are conventionally applied intermittently, with dose duration of the order of hours, intervals between doses of days or weeks, and cycles repeated for weeks. The large number of possible combinations of values of duration, interval, and lethality has been an impediment to empirically determine the optimal set of treatment conditions. The purpose of this project was to determine the set of parameters for duration, interval, and lethality that would be most effective for treating early colon cancer. An agent-based computer model that simulated cell proliferation kinetics in normal human colon crypts was calibrated with measurements of human biopsy specimens. Mutant cells were simulated as proliferating and forming an adenoma, or dying if treated with cytotoxic chemotherapy. Using a high performance computer, a total of 28,800 different parameter sets of duration, interval, and lethality were simulated. The effect of each parameter set on the stability of colon crypts, the time to cure a crypt of mutant cells, and the accumulated dose was determined. Of the 28,800 parameter sets, 434 parameter sets were effective in curing the crypts of mutant cells before they could form an adenoma and allowed the crypt normal cell dynamics to recover to pretreatment levels. A group of 14 similar parameter sets produced a minimal time to cure mutant cells. A different group of 9 similar parameter sets produced the least accumulated dose. These parameter sets may be considered as candidate dose schedules to guide clinical trials for early colon cancer.
A GABAergic Maf-expressing interneuron subset regulates the speed of locomotion inDrosophila
Authors: Babski H , Surel C , Yoshikawa S , Valmier J , Thomas J.B , Carroll P , Garcès A 
Published: September 2018

AbstractInterneurons (INs) coordinate motoneurons activity to generate adequate patterns of muscle contractions, providing animals with the ability to adjust their body posture and to move over a range of speeds. In theDrosophilalarvae several IN subtypes have been morphologically described and their function well documented. However, the general lack of molecular characterization of those INs prevents the identification of evolutionary counterparts in other model animals, limiting our understanding of widespread principles ruling neuronal circuits organization and functioning. Here we characterize a highly restricted neuronal subset expressing the Maf transcription factor Traffic Jam (TJ). We found that TJ+neurons are highly diverse and their activation using intersectional genetics disrupted larval body posture and locomotion speed. We also showed that a small subset of TJ+GABAergic INs, singled out by the unique expression ofPer,Fkh,GrainandHlh3b, a molecular signature reminiscent to V2bINs in vertebrate, impacted the larvae crawling speed.
Identification and Classification of Differentially Expressed Genes in Renal Cell Carcinoma by Expression Profiling on a Global Human 31,500-Element cDNA Array
Authors: Boer Judith M. , Huber Wolfgang K. , Sültmann Holger , Wilmer Friederike , von Heydebreck Anja , Haas Stefan , Korn Bernhard , Gunawan Bastian , Vente Andreas , Füzesi Laszlo , Vingron Martin , Poustka Annemarie 
Published: September 2018

We investigated the changes in gene expression accompanying the development and progression of kidney cancer by use of 31,500-element complementary DNA arrays. We measured expression profiles for paired neoplastic and noncancerous renal epithelium samples from 37 individuals. Using an experimental design optimized for factoring out technological and biological noise, and an adapted statistical test, we found 1738 differentially expressed cDNAs with an expected number of six false positives. Functional annotation of these genes provided views of the changes in the activities of specific biological pathways in renal cancer. Cell adhesion, signal transduction, and nucleotide metabolism were among the biological processes with a large proportion of genes overexpressed in renal cell carcinoma. Down-regulated pathways in the kidney tumor cells included small molecule transport, ion homeostasis, and oxygen and radical metabolism. Our expression profiling data uncovered gene expression changes shared with other epithelial tumors, as well as a unique signature for renal cell carcinoma.[Expression data for the differentially expressed cDNAs are available as a Web supplement athttp://www.dkfz-heidelberg.de/abt0840/whuber/rcc. The array data have been submitted to the GEO data repository under accession no. GSE3.]
Sequence, Regulation, and Evolution of the Maize 22-kD α Zein Gene Family
Authors: Song Rentao , Llaca Victor , Linton Eric , Messing Joachim 
Published: September 2018

We have isolated and sequenced all 23 members of the 22-kD α zein (z1C) gene family of maize. This is one of the largest plant gene families that has been sequenced from a single genetic background and includes the largest contiguous genomic DNA from maize with 346,292 bp to date. Twenty-two of the z1C members are found in a roughly tandem array on chromosome 4S forming a dense gene cluster 168,489-bp long. The twenty-third copy of the gene family is also located on chromosome 4S at a site ∼20 cM closer to the centromere and appears to be the wild-type allele of the floury-2(fl2) mutation. On the basis of an analysis of maize cDNA databases, only seven of these genes appear to be expressed including the fl2 allele. The expressed genes in the cluster are interspersed with nonexpressed genes. Interestingly, some of the expressed genes differ in their transcriptional regulation. Gene amplification appears to be in blocks of genes explaining the rapid and compact expansion of the cluster during the evolution of maize.[The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AF090447,AF031569, and AF090446]
Sites of translation in digital reporting
Authors: Locke Joanne , Rowbottom Nick , Troshani Indrit 
Published: September 2018

Purpose
The purpose of this paper is to analyse the process by which “analogue” corporate reports produced under a “paper paradigm” are translated into a machine language as required by digital reporting. The paper uses Austin and Searle’s linguistic speech act theory to examine how digitally translating reporting information into atomised data affects the infrastructure and practice of accounting.

Design/methodology/approach
Extensive interview and observation evidence focussed on the IFRS Foundation’s digital reporting project is analysed. An interpretive approach is informed by the concepts of L compatibility, illocution and perlocutionary acts which are drawn from speech act theory.

Findings
Two key sites of translation are identified. The first site concerns the translation of accounting standards, principles and practices into taxonomies for digital tagging. Controversies arise over the definition of accounting concepts in a site populated by accounting and IT-orientated experts. The second site of translation is in the routine production and dissemination of digital reports which impacts the L compatibility between preparers and users.

Originality/value
The paper highlights a previously unexplored field of translation in accounting and contributes a unique perspective that demonstrates that machine translation is no longer marginalised but is the “primary” text with effects on the infrastructure and practice of accounting. It extends speech act theory by applying it to the digital domain and in the context of translation between languages.
Multirotor UAV sensor fusion for precision landing
Authors: Grzes Michal , Slowik Maciej , Gosiewski Zdzisław 
Published: September 2018

Purpose
In relation to rapid development of possible applications of unmanned vehicles, new opportunities for their use are emerging. Among the most dynamic, we can distinguish package shipments, rescue and military applications, autonomous flights and unattended transportation. However, most of the UAV solutions have limitations related to their power supplies and the field of operation. Some of these restrictions can be overcome by implementing the cooperation between unmanned aerial vehicles (UAVs) and unmanned ground vehicles (UGVs). The purpose of this paper is to explore the problem of sensor fusion for autonomous landing of a UAV on the UGV by comparing the performance of precision landing algorithms using different sensor fusions to have precise and reliable information about the position and velocity.

Design/methodology/approach
The difficulties in this scenario, among others, are different coordination systems and necessity for sensor data from air and ground. The most suitable solution seems to be the use of widely available Global Navigational Satellite System (GNSS) receivers. Unfortunately, the position measurements obtained from cheap receivers are encumbered with errors when desiring precision. The different approaches are based on the usage of sensor fusion of Inertial Navigation System and image processing. However most of these systems are very vulnerable to lightning.

Findings
In this paper, methods based on an exchange of telemetry data and sensor fusion of GNSS, infrared markers detection and others are used. Different methods are compared.

Originality/value
The subject of sensor fusion and high-precision measurements in reference to the autonomous vehicle cooperation is very important because of the increasing popularity of these vehicles. The proposed solution is efficient to perform autonomous landing of UAV on the UGV.