bluuebunny/crossref_metadata_2025_split huggingface dataset:
965-P: Glucose Sensor Accuracy after Subcutaneous Glucagon Injections Near to Sensor Site
Authors: LAUGESEN CHRISTIAN , SCHMIDT SIGNE , TETZSCHNER RIKKE , NØRGAARD KIRSTEN , RANJAN AJENTHEN 
Published: June 2019

Aim: To compare sensor accuracy (Medtronic Enlite2®) after a subcutaneous (s.c) injection of low-dose glucagon near vs. remote from sensor site.
Methods: Twelve adults with type 1 diabetes wore two continuous glucose monitors (CGMglucagon and CGMctrl) placed on each side of the abdomen during two overnight in-clinic visits. CGM values were compared with YSI values. Four hours prior to visit end, a s.c 100 µg glucagon injection was administered 0.2 cm next to the CGMglucagon, and 2 hours later another bolus was injected next to the same sensor. Afterwards, CGM performance was compared with 3-day self-monitoring of blood glucose (SMBG) in free-living conditions.
Results: Using YSI as comparator, the overall median absolute relative difference (MARD) for CGMglucagon (N=772) was 17.9% and 14.7% for CGMctrl (N=1352), p=0.15. The percentage of values in zone A+B of Clarke Error Grid Analysis was 96.9% for YSI-CGMglucagon and 97.0% for YSI-CGMctrl, p=0.98. With respect to SMBG, the MARD for CGMglucagon (N=319) was 19.3% and 13.8% for CGMctrl (N=464), p=0.02. The percentage of values in zone A+B for SMBG-CGMglucagon was 94.7% compared to 97.2% for SMBG-CGMctrl, p=0.77. The precision absolute relative deviation between sensors was 16.0%.
Conclusion: The study indicates that sensor accuracy may be affected by s.c. glucagon injections near to sensor site compared with distant injections. However, the effect may not be of clinical relevance.

Disclosure
C. Laugesen: None. S. Schmidt: Speaker's Bureau; Self; Novo Nordisk A/S. R. Tetzschner: None. K. Nørgaard: Advisory Panel; Self; Abbott, Medtronic, Novo Nordisk A/S. Speaker's Bureau; Self; Bayer US, Medtronic, Roche Diabetes Care, Rubin Medical, Sanofi, Zealand Pharma A/S. Stock/Shareholder; Self; Novo Nordisk A/S. A. Ranjan: None.

Funding
Danish Diabetes Academy
971-P: The Precision and Accuracy of Many Modern Blood Glucose Meters at High Altitude
Authors: ZENGMEI SUN , YUNHONG WU , SUYUAN WANG , YANFANG ZHAO , JING YANG , RONG XIAO , YAN YE , XUANYU YAO , HUIQIN ZHANG 
Published: June 2019

Objective: Self-monitoring of blood glucose (SMBG) is an important method of glucose control in diabetic patients. The result of blood glucose meters are influenced by temperature, oxygen concentration, low atmospheric pressure or dry factors related to altitude. In this study, we aimed to evaluating the precision and accuracy of seven SMBG meters commonly used in plain market of China.
Methods: A total of 97 medical examinations living in NaQu distract (at altitude 3900m) were included in this study. We received 91 venous blood samples including seven glucose levels and 5 Venous blood samples including five glucose levels to analyze accuracy and precision respectively based on ISO15197:2013. Every sample was measured in duplicate by two meters of each brand of SMBG meter. Plasma separated to blood cells in 5 minutes and used for laboratory reference measurement in 30 minutes after obtain results by SMBG meters.
Results: Accuracy criteria were set at a bias&lt;15% from reference glucose (when &gt;5.6mmol/L)and&lt;0.83 mmol/L from reference glucose(when&lt;5.6mmol/L).There was only one brand SMBG meter consistent with standard of ISO. But the percentages of readings within Consensus Error Grid zone A and B of seven brand meters were all over 95% (98.9%∼100%). The precision of the result demonstrated that standard deviation for glucose concentration ≥5.6 mmol/L of seven brand meters were all less than 0.42 mmol/L. And coefficient of variation (CV) for glucose concentration &lt;5.6 mmol/L were all less than 7.5%.
Conclusion: Altitude environment influenced the performance seriously of SMBG meters especially for accuracy. So choosing glucose meter brand should be cautious at high altitude.
Tab 1 Precision results of 7 brand glucose meters.

Disclosure
S. Zengmei: None. W. Yunhong: None. W. Suyuan: None. Z. Yanfang: None. Y. Jing: None. X. Rong: None. Y. Yan: None. Y. Xuanyu: None. Z. Huiqin: None.
974-P: Beyond Carbohydrate Counting (CC)
Authors: MELISH JOHN S. 
Published: June 2019

CC is central to diabetes self-management in patients on insulin. Measuring devices, reference materials, and time are required. Continuous glucose monitoring (CGM) is increasingly available to insulin requiring diabetics: a rich data set that can be used to assess glucose appearance (Ra), disposal (Rd), and insulin need beyond CC. Fat and protein also contribute the height and duration of the glucose concentration curve. This is not accounted for with CC. Most patient's base insulin doses on previous meal experience and CGM directional arrows and not CC. CGM provides a means for individualizing insulin management quantitatively beyond premeal CC. Calculations: Data: CGM meal related glucose concentration vs. time curve, Kg body weight to calculate Volume of distribution (Vd). Glucose clearance [CL = (1/time)*Vd)]. (a)=Vd*Pkglucose*e*conversion factor. Conversion factor (CF = 1.12) converts blood glucose to plasma or interstitial fluid glucose (ISF glucose). Meal/insulin taken can be expressed as glucose appearance (a)/insulin or glucose clearance/insulin taken. (a) and CL make it possible to calculate a true area under the curve which differs with the timing and amount of insulin before the meal. Example: Weight 80.1 kg; Vd = 135 dL, time 340 minutes. Baseline glucose (BL) = 71.5 mg/dL. Glucose Peak (Pk) = 159 mg/dL. Insulin taken: 13 units. CL = 43mL/min. Depending on the time insulin is taken before the studied meal: (a) = 159 mg/dL*e*Vd or (a) = (159 mg/dL*e-BL/e) or (a) = ((159 mg/dL*e) - BL)*Vd. CL/insulin and (a)/insulin. In this case: CL = 43 mL/min/13 units; (a) = 48.7 g/13 units. Meal by references: 46.0 g CHO.
Conclusion: This methodology marries pharmacokinetics with diet/insulin responses and goes beyond problematic CC in quantitating glucose appearance and disposal. The calculations determine post-hepatic glucose appearance and disposal. If available meal glucose is known, hepatic glycogen storage can be estimated also. Calculations can be performed using a ruler, cell phone calculator, and CGM glucose curves.

Disclosure
J.S. Melish: None.
975-P: Comparison of Glycemic Variability, Assessed by Continuous Glucose Monitoring System (CGMS) during Early Post-Transplantation Period, between the Recipients of Kidney and Liver Transplantation
Authors: JIN HEUNG YONG , KIM YU JI , LEE KYUNG AE , PARK TAE SUN 
Published: June 2019

Objective: The aim was to investigate the glucose profiles and compare the degree of glycemic variability between kidney and liver transplantation patients during the early postoperative period.
Methods: The continuous glucose monitoring (CGM) data of 31 patients including 24 with kidney transplantation (KT) and seven with liver transplantation (LT) were analyzed.
Results: Post-transplantation diabetes mellitus (PTDM) occurred in 42.1% (8/19) and 16.7% (1/6) of KT and LT patients, respectively, during this early period after transplantation, except for patients with preexisting diabetes (5 KT, 1 LT). Glycemic variability after LT was better than that in KT patients. The average mean amplitude of glycemic excursion (MAGE) and mean absolute glucose (MAG) levels were 91.18±26.51 vs. 65.66±22.55 (P&lt;0.05), 24.62±7.78 vs. 18.18±7.07 (P&lt;0.05) in KT vs.LT patients, respectively, in patients without preexisting DM or PTDM patients (Fig. 1).
Conclusion: The transplanted organ is also an important factor affecting glucose control and the occurrence of PTDM in patients who receive transplantation. Further studies involving CGM follow-up at regular intervals in PTDM or preexisting diabetic patients after KT or LT may clarify the role of transplanted organs in glucose control in recipients of organ transplants.

Disclosure
H. Jin: None. Y. Kim: None. K. Lee: None. T. Park: None.
991-P: Potential of a Novel Long-Acting Glucagon Analog, HM15136, for the Treatment of Obesity
Authors: KIM JUNG KUK , KIM JINYOUNG , LEE SEON MYEONG , LEE JONGSOO , LEE SANG HYUN , CHOI IN YOUNG 
Published: June 2019

Obesity is considered as a main risk factor for metabolic syndrome. Although there are several anti-obesity drugs, their main mode of action (MoA) is appetite suppression. Thus, body weight loss (BWL) efficacy is limited with benefits fading when the drugs stopped. Glucagon (GCG) has been used to treat hypoglycemia. Recent studies indicated a stimulatory effect of GCG on energy expenditure, suggesting its utilization as an anti-obese drug. Since BWL is a key for insulin resistance (IR) reversal and blood glucose (BG) normalization, we hypothesized that sustained GCG treatment may reduce hyperglycemic risk via IR improvement following efficient BWL. To investigate this hypothesis, we developed a novel long-acting GCG analog, HM15136, and evaluated the effect of HM15136 on BW and BG in vivo. In obese animals, HM15136 demonstrated dose-dependent BWL (-21 ∼ -53% vs. Veh. for DIO mice, -10 ∼ -64% vs. Veh. for DIO rats). Of note, despite an initial increase, BG level rapidly normalized. As to the responsible MoA, a reduced blood lipid and HOMA-IR were observed. In vitro studies demonstrated the increased FGF-21 and adiponectin expression by HM15136 in 3T3-L1 adipocytes. These results suggest that HM15136 could improve insulin sensitivity via multiple mechanisms, leading to normal BG maintenance under chronic GCG receptor stimulation. To further investigate the therapeutic potential of HM15136, BWL efficacy was compared to liraglutide: Greater BWL was observed with HM15136 (-34% and -21% vs. Veh. for HM15136 and liraglutide, respectively). Indirect calorimetry demonstrated enhanced energy expenditure by HM15136. Most interestingly, efficient BWL achieved by HM15136 was maintained during 4 weeks drug-holiday, compared to liraglutide.
In conclusion, our results demonstrate the potential for prolonged GCG receptor stimulation with agent like HM15136 as a novel therapeutic option for obesity treatment. Human studies are needed to confirm these findings and to evaluate the potential safety of HM15136.

Disclosure
J. Kim: None. J. Kim: None. S. Lee: None. J. Lee: None. S. Lee: Employee; Self; Hanmi Pharm. Co., Ltd. I. Choi: Employee; Self; Hanmi Pharm. Co., Ltd.
992-P: Dulaglutide (DU) Has Better Glycemic Effectiveness vs. Basal Insulin (BI) in Injection-Naïve Patients with Type 2 Diabetes (T2D): The DISPELTM Study
Authors: MODY REEMA , HUANG QING , YU MARIA , ZHANG XIAN , WANG LIYA , GRABNER MICHAEL , PATEL HIREN 
Published: June 2019

The 2018 ADA-EASD consensus report recommends GLP-1 RAs over BI as the first injectable medication in most patients with T2D. The objective of this U.S. retrospective observational study was to compare 1-year real-world glycemic effectiveness among patients with T2D initiating DU vs. BI.
Patients ≥18 years with T2D initiating DU or BI between Nov’14 - Apr’17 (index date=earliest fill date), and no claim for any antidiabetic injectable in 6 months pre-index period (baseline), continuous enrollment and ≥1 HbA1c result 6 months pre-index and 1-year post-index were identified from a U.S. claims database. DU users were propensity-matched 1:1 to BI users.
The pre-matching mean baseline HbA1c for DU cohort (n=1,103) was 8.4% vs. 9.9% for BI cohort (n=3,193). Matched cohorts (903 pairs) were balanced in baseline characteristics with mean HbA1c: ∼8.6%, mean age: 54 years, SGLT2 inhibitor use: 24% and DPP-4 inhibitor use: ∼38%. At 1-year post-index, 11% of DU cohort used BI and 10% of BI cohort used GLP-1 RAs; DU patients used less rapid-acting insulin (2% vs. 16%) and DPP-4 inhibitors (24% vs. 39%) and more SGLT2 inhibitors (34% vs. 23%) vs. BI patients. The key glycemic effectiveness results are included in the Table.
In this real-world study, patients with T2D initiating DU demonstrated significantly greater and clinically meaningful HbA1c reduction compared to those initiating BI.

Disclosure
R. Mody: Employee; Self; Eli Lilly and Company. Q. Huang: None. M. Yu: Employee; Self; Eli Lilly and Company. Employee; Spouse/Partner; Lifelabs. Stock/Shareholder; Self; Eli Lilly and Company. X. Zhang: None. L. Wang: Employee; Self; HealthCore. Employee; Spouse/Partner; Janssen Pharmaceuticals, Inc. M. Grabner: None. H. Patel: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company.

Funding
Eli Lilly and Company
Investigation of Nursing Student Satisfaction with the First Clinical Education Experience in Universities of Medical Sciences in Iran
Authors: Nejad Farzaneh Mohammad ,   School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Asadizaker Marziyeh ,   Nursing Care Research Center in Chronic Diseases, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,   Marziyeh Asadizaker, Nursing Care Research Center in Chronic Diseases, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Golestan square, Ahvaz, Iran. Tel.: +986133738331; E-mail address: asadizaker-m@ajums.ac.ir, Baraz Shahram ,   Nursing Care Research Center in Chronic Diseases, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Malehi Amal Saki ,   Health Research Institute, Thalassemia & Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Published: June 2019

Satisfaction with the experience gained in clinical settings is of great significance to nursing students and novice first-year students in particular and contributes significantly to developing basic clinical skills and competence. Accordingly, the present study aimed to examine nursing student satisfaction with the first clinical education experience.
A total of 390 second- and third-semester nursing students gaining clinical experience in general surgery, internal medicine, gynecological surgery, orthopedics, emergency, obstetrics and gynecology, ophthalmology, andrological surgery, post-CCU, and otorhinolaryngology departments participated in this analytical cross-sectional study from March to June 2017. The research instrument included the “Assessment of nursing student’s Satisfaction with First Clinical Practical Education Questionnaire: Modified Version”, consisting of three parts: demographic characteristics, 37 items, and a 10-degree visual analog scale to assess student satisfaction. Descriptive statistics were used to hypothesis test in SPSS 22.
The highest rate of student satisfaction was related to the third domain labeled “Instructor’s behavior”, and the lowest rate of student satisfaction was related to the fifth and seventh domains labeled “Emotional atmosphere and learning in the clinical setting” and “Creating appropriate learning opportunities”, respectively. The results of statistical tests suggested a statistically significant relationship between the mean satisfaction score (based on the 10-degree scale) and gender (p=0.01). However, no statistically significant relationship was observed between the mean satisfaction score and other demographic characteristics such as age, grade point average (GPA), and university type.
Student satisfaction rate varies in different domains of the questionnaire. Accordingly, it is recommended that schools of nursing and midwifery incorporate the findings of this study into their first clinical, educational experience planning and take into account the educational needs of students to bring greater satisfaction.
Microbial-mat-associated tephra of the Archean Moodies Group, Barberton Greenstone Belt (BGB), South Africa: Resemblance to potential biostructures and ecological implications
Authors: Köhler I. , Heubeck C. 
Published: June 2019

AbstractDocumenting evidence of fossil microbial life on early Earth is made difficult by the paucity of suitable Archean sedimentary rocks, their common metamorphic overprint, the small outcrop areas, and the small size of the objects of interest. Although a large number of putative microfossils dating back as far as 3700 Ma have been described, the syngeneity and biogenicity of many occurrences is debated, and some of the proposed fossils have been found to be either contaminants or abiotic artefacts. The ~3200 Ma Moodies Group of the Barberton Greenstone Belt (BGB), South Africa, contains locally abundant and remarkably well-preserved microbial mats which show indirect evidence of photosynthetic activity. They also contain microstructures which strongly resemble remains of microbial cells. Detailed morphological and geochemical analyses, however, show that these structures mostly represent fragments of volcanic tephra. Our study demonstrates that opaque microstructures within microbial mats can potentially be misidentified as microfossils even when a strict protocol is followed. It also posits the question to which degree volcanic air-borne fertilization contributed to the remarkable growth rate, high mechanical tenacity and wide extent of these oldest tidal microbial mats in siliciclastic environments.
Развитие музейного дела в Республике Тыва: история и современность
Authors: Bicheldey Kaadyr-ool A. , Chyrgalan Solangy Yu. , Irghit Ottuk Yu. , Kadyg-ool Khulerben K. 
Published: June 2019

90-летний юбилей Национального музея им. Алдан-Маадыр Республики Тыва — повод подвести определенные итоги в области музейного дела Тувы. Музей сегодня является культурным и научным центром республики, играет важную роль в сохранении культуры, в развитии воспитания и пр. В статье анализируется история развития музейного дела в Туве, формулируются современные проблемы и новые вызовы на фоне глобальных трендов, которые происходят с музеями мира.Даны количественные характеристики на сегодня: число сотрудников музея (в том числе по разным категориям), показатели фондов музея. Имеется 7 филиалов. Отмечено, что тувинский музей по фондам является одним из самых богатых в Южной Сибири. Проанализированы виды и показатели научно-исследовательской деятельности коллектива. Отмечены организационные проблемы. Перспективным направлением работы названо археологическое в сотрудничестве с другими научными учреждениями. Представлены формы работы с посетителями. Возможности расширения и улучшения работы показаны на примере филиала — музея истории политических репрессий. Сформулирована задача полной реэкспозиции в залах до 2021 года, которая рассматривается как творческая. Насущная задача — использование современных технологий, которая сейчас решается, но в минимальном виде. Важно соблюсти баланс с привычными формами работы и сохранить статус ведущего культурного и просветительского учреждения Тувы.Международное сотрудничество музея сегодня развивается в двух основных направлениях: обмен выставками с зарубежными музеями и предоставление своей площади для международных мероприятий.
Тувинское горловое пение как нематериальное культурное наследие и как культурный бренд Тувы
Authors: Lamazhaa Chimiza K. , Suzukey Valentina Yu. 
Published: June 2019

В статье анализируются проблемы сохранения тувинского горлового пения — хѳѳмея, который рассматривается как нематериальное культурное наследие Тувы. Соответственно, за основу взяты рекомендации ООН о том, какие задачи должны решаться.Разнообразной информации, в том числе научной, о хѳѳмее собрано много, прежде всего двумя государственными учреждениями Тувы, призванными изучать и развивать тувинское горловое пение — Международным научным центром «Хѳѳмей» и Центром развития тувинской традиционной культуры и ремесел. Есть много публикаций, однако, к сожалению, специализированных каталогов работ по хѳѳмею, а также по исполнителям хѳѳмея, пока нет. Другая группа задач — учет, сбор аудио- и видеозаписей, а также возможность доступа к ним заинтересованных лиц, пока также не решена. Отчасти этим занимаются лишь энтузиасты, при этом иностранные ценители хѳѳмея.Важнейшая задача — сохранение аутентичных, подлинных форм нематериального культурного наследия — осложняется тем, что традиции, передающиеся устным путем, являются «живыми», изменчивыми по своей природе. Сегодня искусство хѳѳмея существует как в своем первозданном виде, так и в современных музыкальных формах, где оно соединяется с различными жанрами популярной, авангардной, джаз и рок музыки и успешно вписался в современные направления world music. Этот успех влияет на международные культурные связи Тувы, на развитие этнокультурного туризма, поэтому может и должен рассматриваться в качестве одного из брендов современной тувинской культуры, а также как этномобилизующий фактор.Профессия артиста горлового пения в 2011 г. в России была легализирована, хѳѳмейжи получили право на специальные профессиональные льготы. И этот факт можно расценивать как организационную победу. Но и сам хѳѳмей, как любая другая форма творчества, нуждается в правовой охране. В мире наблюдается тенденция к аналогизации его с так называемым европейским механизмом звукоизвлечения (двухголосия). Хѳѳмей может быть внесен в государственные и межгосударственные реестры как достояние тувинской этнической культуры. Однако, основная цель здесь — легализация правильной методики обучения студентов хѳѳмею в учебных заведениях культуры.Для дальнейшего развития хѳѳмея важно также международное сотрудничество, как научное, так и практическое.
ENTRE DADOS, PASSOS E RELATOS: A EXPERIÊNCIA DA COLETA DE DADOS DO PMAQ NO ESPÍRITO SANTO
Authors: Riquieri Manuella Ribeiro Lira , Soares Gabriela Barreto , Lima Eliane de Fátima Almeida , Lima Rita de Cássia Duarte 
Published: June 2019

O Programa de Melhoria do Acesso e da Qualidade na Atenção Básica se configura como uma prática avaliativa e de monitoramento permanente para subsidiar gestões municipais, com ferramentas que permitam a oferta de serviços, conforme a necessidade da população. O presente relato de experiência se insere no contexto da coleta de dados do 3º ciclo do PMAQ, realizado no segundo semestre de 2017, no estado do Espírito Santo. A vivência da aplicação dos instrumentos de coleta de dados a partir da visita institucional in loco, permitiu identificar a necessidade de aperfeiçoamento dos instrumentos de coleta de dados, de modo a superar a desigualdade nas práticas cotidianas dos serviços de saúde e garantir ampla participação de usuários no processo avaliativo. A intensidade da vivência perpassou muito além do momento da coleta de dados, fazendo com que os envolvidos desenvolvessem a habilidade de escuta, compartilhassem vivências e experiências, compreendessem a necessidade de respeitar os sujeitos e o lugar que ocupam em suas dinâmicas de vida. A experiência da coleta de dados do PMAQ permitiu identificar que a oferta de uma saúde pública de qualidade é determinada pelo compromisso mútuo - trabalhador, usuário, gestor- atores coparticipantes do direcionamento da política pública de saúde brasileira.
“Tu é Menino ou Menina?” Possibilidades Artográficas em Artes Visuais e Teoria Queer
Authors: Borre Luciana 
Published: June 2019

Numa perspectiva autobiográfica e artográfica, elaborei uma narrativa textual e visual a partir das relações entre teoria queer, artes visuais e educação, criando sentidos sobre questões de gênero e sexualidades em contextos educacionais. A partir de minhas experiências como professora de artes visuais, artista e pesquisadora discorro sobre possibilidades de reconstrução de uma prática pedagógica que possibilita a superação de alguns paradigmas excludentes. Entendendo que o desassossego, o incômodo e a dúvida acompanham minha prática pedagógica, proponho: “o retorno do Mamão-macho” e uma “pedagogia da viadagem”. É recorte de uma investigação de mestrado pelo Programa Associado de Pós-Graduação em Artes Visuais da UFPE/UFPB.
Ceci n’est pas une pipe
Authors: Forte Marcelo 
Published: June 2019

O presente texto traz algumas reflexões acerca do desenvolvimento de um diário de pesquisa doutoral, intitulado ceci n’est pas une pipe, produzido a partir dos pressupostos metodológicos da a/r/tografia. Nesse sentido, arte, pesquisa e docência são os principais pontos de discussão do texto, que são tramados juntos a exemplos extraídos das páginas do diário.