bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report of bioprosthetic valve dysfunction after tricuspid valve replacement in a preschool patient: the contribution of pannus and calcification
Authors: Glushkova T. V. , Ovcharenko E. A. , Batranin A. V. , Klyshnikov K. Yu. , Kudryavtseva Yu. A. , Barbarash L. S. 
Published: September 2018

Aim. To assess the contribution of pannus and calcification to the development of bioprosthetic valve dysfunction after tricuspid valve replacement in a pediatric patient.Materials and methods. A 3-month-old patient presented with tricuspid valve dysplasia and grade 4 tricuspid insufficiency underwent tricuspid valve replacement with the bioprosthesis «PeriCor» (ZAO «NeoKor», Russian Federation). The patient at the age of 6 years required a redo tricuspid valve replacement 5 years 8 months after initial surgery. Degenerative changes of the dysfunctional bioprosthetic valve explanted from the tricuspid position were assessed using macroscopic description and light microscopy. Cellular composition, the presence of bacteria, colocalization of calcifications with recipient cells were analyzed. The distribution of calcifications and their volume in the biomaterial tissue were estimated using microcomputer tomography imaging (micro-CT).Results. Bioprosthetic valve dysfunction was mainly caused by the pannus formation which was shown to encapsulate the anterior leaflet, resulting in its total failure and severe stenosis (reduced effective orifice area). There were no signs of ruptures and perforations in the valve tissues found. All leaflets were shown to contain predominantly fibroblastic cells and single blood cells, mainly located in the surface layers of the leaflets in the regions without any signs of calcification. Bacteria staining was negative for all types of the studied biomaterials. Calcifications were present in all xeno-tissue elements of the explanted bioprosthesis (i.e. leaflets, aortic segment, and pericardium). In addition, calcifications were also found in pannus growing during a functioning bioprosthetic valve. Calcifications were predominantly located in the co-optation and commissure zones of the leaflets. Importantly, massive calcifications were observed around the bioprosthetic stent frame. The total volume of calcification accounted for 1/3 of the biological component of the bioprosthesis (729 mm3).Conclusion. According to the data obtained in this study, we may conclude that the primary cause of the bioprosthesis failure was the growth of connective tissues, resulting in pannus-related dysfunction, rather than severe calcification of all bioprosthetic components. One may assume that bioprosthetic dysfunction is related to the peculiarity of the inflammatory response of the preschool patient. However, this typeof dysfunctions requires further investigation.
Conversion to everolimus to preserve kidney function in a heart transplant recipient, a personalized approach of immunos uppressive therapy
Authors: Koloskova N. N. , Nikitina E. A. , Zakharevich V. M. , Muminov I. I. , Cvan V. S. , Poptsov V. N. , Ahmadzai R. L. , Izotov D. A. , Shevchenko A. O. 
Published: September 2018

Heart transplantation is the «gold standard» of treatment severe heart failure. Patient survival after heart transplantation has improved dramatically since the availability of calcineurin inhibitor (CNIs). However, nephrotoxicity of CNIs has been largely responsible for the progressive development of renal dysfunction and reduces long-term patient survival. Use mTOR inhibitor in immunosuppressive therapy may improve renal function when everolimus is administered associated with a progressive reduction of CNIs. The purpose of our report is to demonstrate the successful case of conversion of the recipient after heart transplantation to everolimus and to evaluate the effectiveness of this drug during the observation year after heart transplantation.
Diagnostic possibilities of using micro-RNA for kidney transplantation
Authors: Pirozhkov I. A. , Malyshev M. E. , Reznik O. N. , Manukovsky V. A. , Skvortsov A. E. 
Published: September 2018

Allogeneic kidney transplantation is the optimal approach for the treatment of patients with terminal stage of chronic kidney disease. Moreover, post-transplant monitoring and optimization of immunosuppressive therapy with early non-invasive molecular-biological markers can significantly improve the long-term outcome of transplantation. As markers of damage to the kidney transplant, it is proposed to use micro-RNAs that play a fundamental role in the regulation of the activity of various genes. The level of expression of micro-RNA in different tissues can correlate with certain pathological conditions. In this review, the literature data on the study of the perspectives for the use of micro-RNA as biomarkers of the post-transplantation period in kidney transplant recipients are considered.
Three-stage cytopenia in a child with congenital cavernous transformation of the portal vein
Authors: Lokhmatova M. E. , Taishikhina I. O. 
Published: September 2018

The article represents a case of observation the patient aged 1 year 9 months with an isolated thrombocytopenia with a drop in platelets to 98 thousand/μL, that had been progressed during 1 year to three-stage cytopenia, which was the result of a congenital cavernous transformation of the portal vein. The differential diagnosis of young children’s cytopenia is a complex clinical task, which can be followed by errors in the diagnosis and, accordingly, the choice of therapy. The care of clinicians regarding only hematological pathology can lead to the confusion. The absence of clinical manifestations and moderate deviations in the hemogram (Hb – 98 g/l, RBC– 4.64 × 1012/l, PLT – 98 × 109/l, WBC – 5.0 × 109/l, GR – 0.79 × 109/l) made the diagnostic search rather difficult in this case.
What is an author like Borges? Relation between "The Library of Babel" and the theory of Michel Foucault.
Authors: Cavallin Claudia V 
Published: September 2018

Foucault talks about the relation of attribution, where Borges can be attributed everything related with things that he said or written. In this essay I define the actions in the name of an author like Borges, related to the category of the proper name. His name is more than a gesture, is part of his connexion between words and things. As Foucault says, Borges is the author of a novel and he is responsible for more than his own text. Borges use connections, different types of discourse and the author's position in a discursive field. The author's name may be relevant in certain circumstances and I would like to define that kind of circumstances in Borges.
Studi Karakteristik Tipe Diabetes pada Tikus (Rattus novergicus) yang Diinduksi Deksametason (CHARACTERISTIC STUDY OF THE TYPE OF DIABETES IN RAT (RATTUS NOVERGICUS) MODEL INDUCED BY DEXAMETHASONE)
Authors: Hanim Rahmania , Darusman Huda Shalahudin , Rahminiwati Min 
Published: September 2018

Diabetes is marked by hyperglicemia with severe symptoms included polydipsi, polyuri, polyphagia,weight loss, and decreased of insulin sensitivity index specially at type 2 diabetes mellitus. The objective of this research was to analyze the characteristics of diabetes mellitus in rat (Rattus novergicus) which induced by dexamethason. A total of 24 rats were divided into four groups which divided as follow: (1) aquabidest subcutaneously (K0), (2) subcutaneous dexamethasone 1 mg/kgBW daily (K1), (3) subcutaneous dexamethasone 2.5 mg/kgBW daily (K2) and subcutaneous dexamethasone 5 mg/kgBW daily (K3). The data of fasting blood glucose, fasting blood insulin, body weight and feed intake, urine volume and water intake collected at day 0, 5, 10 and 15 (five days after the last treatment). The result showed that there was a significant elevation of glucose level followed by significant decreased of insulin sensitivity index and the body weight of rats in group wich induced by dexamethasone but there was no change in feed intake, water intake, volume of urine and fasting blood insulin before and after the treatment. There was insignificant different of total beta pancreatic islet between treatment and control grup. Induction of dexamethasone in mice causes reversible hyperglycemia and has not met the characterisics of either type 1 or 2 diabetes mellitus models. The profile of dexamethasone induced diabetes model has their own spesific type.
Robert A. Dodgshon. No Stone Unturned: a History of Farming, Landscape and Environment in the Scottish Highlands and Islands.
Authors: Ralston Ian 
Published: September 2018

Robert A. Dodgshon. No Stone Unturned: a History of Farming,
Landscape and Environment in the Scottish Highlands and Islands.
Edinburgh: Edinburgh University Press, 2015. Pp 299. ISBN 978 1
4744 0074 9. $US 135.00.
Legal Analysis on the Policy of Home Ownership Requirements for Foreigners in the Consumer Credit Agremeent of Syariah Bank in Indonesia
Authors: Eka Husnul Khotimah Rachmadani 
Published: September 2018

The study examines the normative policy on the ownership rules of residential homes for foreigners in the credit agreement consumption of Syariah banks in Indonesia. This policy has existed since 2005. However, it does not make all Syariah banks in Indonesia provide credit facilities to foreigners since there is no specific implementing regulation and legal protection for the banks in the case of finance arrears caused by the practice which can disrupt their liquidity and profitability. Considering this, the article analyses the legal protection for Islamic banks, both in preventive and repressive context, in providing credit facilities for foreigners, so that they all can facilitate loans without any fears and risks. This becomes necessary as it can contribute to Indonesia’s economic growth. It argues that the law should cover this matter, through both preventive and restrictive measures, in which the law should prevent the practice from causing finance arrears through musyārakah contract. The results of this study confirm that there is legal protection that has been regulated by Bank Indonesia for Syariah Bank in giving credit to a foreigner.Keywords: Legal Policy, Syariah Bank, Foreigners, Consumer Credit Agreement
Control of local stress in semiconductor silicon structures
Authors: Sianko S. F. , Zelenin V. A. 
Published: September 2018

Residual stress distribution in multilayer semiconductor structure is complicated and has a significant impact on device characteristics and yield, therefore their study is one of the actual tasks of modern device engineering. Purpose of the present work was to develop methods of estimation of actual residual stress distribution at the whole area of semiconductor structure and its elements as well.The estimation of residual stress distribution at the area of semiconductor structure was carried out on the basis of determining of local deformation of some areas of the structure by Makyoh topography. This method is based on consequent measurements of intensity of Makyoh image elements of the structure along the chosen direction followed by calculation of micro-geometrical profile and curvature radius.The estimation of residual stress of topological elements Si–SiO system was carried out by means of calculation of interference pictures obtained in a film-substrate gap after separating of film edge from substrate along open window perimeter.Analytical expressions relating semiconductor structure image characteristics with their deformation were developed by means of finite elements method. The expressions allow determining of local residual stress of chosen area of the structure. The examples of stress calculations in real structures are given.Proposed residual stress calculation methods allow to take into consideration character and curvature form of substrate, and also to estimate their magnitude in real topological elements of semiconductor circuits.
Error estimation of the physical and mechanical characteristics measurements by indentation
Authors: Kren A. P. , Matsulevich O. V. , Delendik M. N. 
Published: September 2018

The active application in the practice of testing the indentation methods, in particular to measure the physical and mechanical properties of metals, polymers, biological technologies demands to development techniques for the measurement error estimation. At the same time existing traditional measurement error evaluation system, based on the using of the reference blocks, is not always suitable for use in testing and research laboratories. The aim of this work was development the technique for estimating the indirect measurements error of materials physical and mechanical characteristics that can be applied in practice and based on the existing standards. Checking of the proposed approach using the experimental values of the hardness and elastic modulus obtained during static indentation for various metals.It is shown that since the initial information about the material is an indentation curve representing the dependence of the load versus penetration depth of the indenter into the material tested, then it is better to confirm the metrological characteristics of the indentation measuring devices using the applied force and achieved displacement, but to estimate the accuracy of determining the properties through the error of indirect measurements. The equations for calculating the hardness and modulus of elasticity are derived. It allows to determine the component value most influencing the error magnitude. The calculation of error on the base of the value of boundary of a random and non-exclusive systematic error was carrying out.The advantage of the developed technique is the fact that the measurement of the physical and mechanical characteristics is based on the experimental data and does not require the creation of the additional metrological assurance. The proposed approach seems appropriate to extend for the determination of the measurement error of other characteristics: the yield point, the strain hardening exponent, creep, relaxation, determined by the indentation methods.
Pharmacological cardioversion by nifekalant after release of the aortic cross‐clamp during cardiac surgery
Authors: Hayashi Yukio , Sakai Mika , Tachibana Yosuke , Saiki Emiri , Miyata Yuka 
Published: September 2018

SummaryElectrical cardioversion is usually performed when ventricular tachycardia and ventricular fibrillation occur following the release of the aortic cross‐clamp during cardiopulmonary bypass. However, electrical cardioversion has been associated with myocardial damage. Pharmacological cardioversion for ventricular dysrhythmia in cardiac surgery may be advantageous. We report four successful cases of pharmacological cardioversion using nifekalant, a pure potassium‐channel blocker, for ventricular tachycardia and ventricular fibrillation following the release of aortic cross‐clamp during cardiac surgery. We argue that pharmacological cardioversion by nifekalant has certain advantages over electrical cardioversion because it may suppress myocardial damage.
CONTRIBUTION OF PROFESSOR N.F. FILATOV (1847–1902)
Authors: Morgoshiia T. Sh. 
Published: September 2018

It was noted that during 25 years of scientific and teaching activity N. F. Filatov has made a significant contribution to the development of world Pediatrics. He is the author of over 70 scientific works, including «A short textbook of pediatric diseases» (1893), that was published in 12 editions, and «Clinical lectures» (1900). His monograph «Lectures on acute infectious diseases» (1885) was published in 4 editions, «Semiotics and diagnosis of childhood diseases» (1890) – 9 editions, it istranslated into German, Czech, Italian, Hungarian and French. Many generations of pediatricians have studied on N.F. Filatov’s monographs and manuals. He described the infectious disease named Filatov scarlatinal rubella. Later it was described by the British physician Dukes; one of the presently used names of the disease is Filatov-Dukes disease. In the first edition of «Lectures on infectious diseases» N. F. Filatov described not known until that time infectious mononucleosis, which he called idiopathic inflammation of the cervical lymphatic nodes. The disease is now often called the Filatov’s disease. In 1895 N. F. Filatov, described an important diagnostic sign of measles – the appearance in the catarrhal period of illness of grayish-white lesions on the mucose membrane of lips and cheeks 1–2 days prior to the appearance of rash. As was established later, this sign was first described by A. P. Belsky in 1890, then, independently, by N.F. Filatov, and in 1896 by Koplik. In the literature, this symptom is known as Belsky-Filatov-Koplik spots. N.F. Filatov described the pathogenesis of some forms of oedema syndrome in children, published works on prolonged afebrile forms of the flu. N.F. Filatov was developing a clinical-physiological direction in Pediatrics. He created a large school of native pediatricians. Among his students were famous pediatricians V.I. Molchanov and G.N. Speransky.
AGE FEATURES OF INTESTINAL AMOEBIASIS
Authors: Kharchenko G. A. , Kimirilova O. G. 
Published: September 2018

Study objective. To establish clinical and epidemiological features of intestinal amebiasis in adults and children at the present stage. A retrospective analysis of patient histories of 90 cases of intestinal amebiasisin patients aged 3 to 40 years who were on inpatient treatment in Regional Infectious Clinical Hospital named after A.M Nichogi, Astrakhan, in the period from 2014 to 2017. The diagnosis of amebiasis was confirmed by microscopy of feces, detection of antibodies by using reaction of indirect hemagglutination (RHAG) with a specific antigen, determination of DNA of the parasite by polymerase chain reaction (PCR).Results. It was determined that the incidence of intestinal amebiasis in the Astrakhan region is sporadic with the involvement in the epidemic process of persons of working age from 18 to 40 years (75.6%) and children aged 3 to 10 years (24.6%) of organized groups living in the city. Acute intestinal amebiasis in 86.8% of adults proceeded in mild to moderate form. The clinical course of the disease was characterized by a gradual onset in 82.4%, mucosal-bloody stool in 94.1%, the outcome of a chronic recurrent form in 11.8%. Raspberry jelly-like stool, extraintestinal complications of amebiasis, characteristic of amebiasis of previous years, were absent.The features of intestinal amebiasis in children were: acute onset of the disease in 63.6%, fever 38°C and above in 54.5%, abdominal pain in 95.5%, prolonged diarrhoea with a stool frequency of more than 10 times in 72.7%, stool with blood mucus in 95.5%, tenesmus in 36.4%, dehydration in 18.6% of patients. The mild form of the disease in children was not observed, severe was observed in 54.5%, moderate in 45.5%. The combined course of intestinal amebiasis with bacterial dysentery, proceeded more severely, changed clinical symptoms of the disease, made it difficult to diagnose amebiasis in a timely manner.
Varenicline is More Effective than Nicotine Replacement Therapy During Pregnancy: Findings from the Smoking MUMS (Maternal Use of Medications and Safety) Study
Authors: Choi Stephanie KY , Tran Duong T , Preen David B , Randall Deborah , Kemp-Casey Anna , Einarsdottir Kristjana , Jorm Louisa R , Havard Alys 
Published: September 2018

IntroductionStudies in the general population suggest that varenicline is more effective than nicotine replacement therapy (NRT) for smoking cessation. However, clinical guidelines recommend against the use of varenicline during pregnancy and suggest NRT be used when the expected benefits outweigh the potential risks.
Objectives and ApproachWe evaluated whether varenicline was more effective than NRT for smoking cessation when used during pregnancy. Routinely-collected records of all births (01/01/2011-12/31/2012) in New South Wales and Western Australia were used to identify a cohort of women who smoked during the first 20 weeks of pregnancy. Pharmaceutical dispensing data were then linked to identify varenicline or NRT dispensing in the first 20 weeks of pregnancy. Smoking cessation was defined as women reported not smoking after the first 20 weeks of pregnancy. Inverse probability of treatment weighting with propensity scores were used to account for differences between the two treatment groups.
ResultsOverall, 117 women used varenicline and 135 NRT in the first 20 weeks of pregnancy. In the unweighted sample, more women who used varenicline quit smoking after the first 20 weeks than women using NRT (28.2% vs. 11.1%, crude rate difference:17.1%, 95% confidence intervals[CI]:7.4-26.8%). In the weighted sample, quitting rate was 12.7% (95%CI:0.8-24.6%) higher in pregnant smokers who used varenicline (27.4% vs. 14.7%) when compared to those who used NRT.
Conclusion/ImplicationsPregnant smokers using varenicline were more likely to quit smoking than those using NRT. This information will assist healthcare providers to make informed recommendations, but data regarding safety of varenicline in pregnancy are also urgently needed. Future studies with greater statistical power are required to confirm our results.
Flooding Model as the Analysis of the Sea Level Increase as a Result of Global Warming in Coastal Area in Lampung
Authors: Kurniawan Agung 
Published: September 2018

The melting of ice layers, as a direct impact on global warming, is indicated from a lesser thickness of ice layers is specifically causing an increase on the sea level. Lampung, as a province that has an ecosistem of regional coast, can be estimated to submerge. Flood modelling can be done to know the estimated flood range. The model of the flooded region is taken from Shuttle Radar Topography Mission(SRTM) data, which is nomalized to get the visualisation of Digital Elevation Model (DEM). The purpose of this research is to know the estimated region of provincial coast of Lampung that is going to be flooded because of the raising of sea surface. This research uses flood inundation technique that uses one of the GIS mapping software. The result can be used as consideration to achieve policy in the building of regional coast. The regions that are flooded based on the scenario of the raising of two and three meter surface sea level are East Lampung Regency, West Lampung Regency, South Lampung Regency, Tanggamus Regency, Pesawaran Regency, and Bandar Lampung.