bluuebunny/crossref_metadata_2025_split huggingface dataset:
PYGRID: A software development and assessment framework for grid‐aware software defined networking
Authors: Samir Mohamed , Azab Mohamed , Rizk Mohamed R. M. , Sadek Nayera 
Published: August 2018

AbstractThe Internet of Things (IoT) envisions to connect Advanced Metering Infrastructure (AMI) to the Internet to facilitate efficient resource management in smart cities. Smart grid is the evolutionary approach towards a more dynamic, situation‐aware, and elastic power systems in smart cities. However, due to the huge scale, heterogeneity and complexity of the many interconnected cyber and physical devices, current network and security technologies are incapable of best serving these needs. Destructive attacks targeting these components such as Denial of Service (DoS) may fully use grid structure and disrupt its crucial service. Recent researches offer the use of modern Software Defined Networking (SDN) to solve synonymous Cyber Physical Systems (CPS) network and security challenges. These researches noted the lack of an adequate platform to simulate grid systems network infrastructure. Therefore, in this paper, we present PYGRID, a software development and assessment framework for grid‐aware SDN. Additionally, a top level SDN application is developed in SDN‐enabled smart grid network to demonstrate the effectiveness of such merger and to mitigate DoS attacks. PYGRID is developed using PYTHON, an OSI‐approved open source language considering standard client and server industrial communication protocols. IEEE 14‐bus power system is adopted to demonstrate the potent and effectiveness of the proposed solution. We conducted multiple experiments to validate the developed framework over 14‐bus system using PYPOWER. To the best of our knowledge, the resulted platform may be considered the first completely open source implementation of a secure SDN enabled smart grid simulator.
Clinical experience with sex chromosome aneuploidies detected by noninvasive prenatal testing (NIPT): Accuracy and patient decision‐making
Authors: Ramdaney Aarti , Hoskovec Jennifer , Harkenrider Jacqueline , Soto Eleazar , Murphy Lauren 
Published: August 2018

AbstractObjectiveThe objectives of the study are to assess the accuracy of noninvasive prenatal testing (NIPT) for sex chromosome aneuploidies (SCAs) and to investigate patient decision‐making in clinical practice.Study designThis is a retrospective cohort study review of positive NIPT results for SCAs from January 2013 to September 2017.ResultsOf the 136 positive NIPT results for SCAs, 73 (53.7%) were positive for 45,X, 62 (45.6%) were a sex chromosome trisomy, and 1 was a sex chromosome tetrasomy. Of the 134 viable pregnancies, 46 (34.3%) elected to pursue prenatal diagnosis. Fewer women underwent invasive prenatal testing when counseled regarding a positive NIPT for monosomy X in the presence of suggestive ultrasound findings (4/23; 17.4%) compared with those who had a positive NIPT result without ultrasound findings (24/46, 52.2%). Abnormal karyotypes consistent with the NIPT result were confirmed in 30/64 (46.9%). Even in the context of ultrasound abnormalities, there was not 100% concordance.ConclusionsThe majority (88/134; 65.7%) of patients in our cohort declined prenatal diagnosis even in the presence of associated ultrasound findings. Comprehensive pretest and posttest counseling is recommended and should address the importance of confirmatory testing and benefits of early diagnosis. Practice guidelines are needed to address provider responsibilities about postnatal testing.
Effects of endophytic fungi in Mongolian pine on the selection behavior of woodwasp (Sirex noctilio) and the growth of its fungal symbiont
Authors: Wang Li‐Xiang , Ren Li‐Li , Liu Xiao‐Bo , Shi Juan , Wang Jing‐Zhen , Luo You‐Qing 
Published: August 2018

AbstractBACKGROUNDThe European woodwasp, Sirex noctilio, is a global invasive pest, attacking a wide variety of pine species by inoculating spores of a symbiotic fungus (Amylostereum areolatum) at oviposition. The woodwasp larvae depend on the growth of the symbiotic fungus to feed. The relationship among host endophytic fungi, symbiotic fungus and woodwasp remain elusive. Here, the effects of endophytes in Mongolian pine on the growth of Amylostereum areolatum and the selection behavior of female woodwasp were investigated by quantifying the mycelium growth rates and olfactometry assays.RESULTSThe endophytic plant fungi, Trichoderma harzianum, Phlebiopsis gigantea, T. viride and T. atroviride, completely killed the mycelia of Amylostereum areolatum. Mycelium fermentation broth of Chaetomium globosum inhibited the growth of the symbiont. Moreover, we observed that volatiles of Ophiostoma minus and Aspergillus niger (acetophenone, acetylacetone, hexadecane, phenylethyl alcohol, and isopropyl myristate) had repellent effects on adult female woodwasp. While volatiles of Amylostereum areolatum ((–)‐globulol, 2‐hexene, cycloprop[e]indene‐1a,2(1H)‐dicarboxaldehyde, terpene and cyclopentanone) had a significant attractiveness to adult female woodwasp.CONCLUSIONSSome species of the host endophytic fungi had a significant negative effect on the growth and development of woodwasps, which could be useful in the monitoring and effective management of woodwasps. © 2018 Society of Chemical Industry
Effect of glucoraphanin and sulforaphane against chemotherapy‐induced neuropathic pain: Kv7 potassium channels modulation by H2S release in vivo
Authors: Lucarini Elena , Micheli Laura , Trallori Elena , Citi Valentina , Martelli Alma , Testai Lara , De Nicola Gina Rosalinda , Iori Renato , Calderone Vincenzo , Ghelardini Carla , Di Cesare Mannelli Lorenzo 
Published: August 2018

The beneficial effects of isothiocyanate‐based compounds, as well as their safety, have been shown in neuropathological disorders, such as neuropathic pain. Aim of the present work was to study the efficacy of the glucosinolate glucoraphanin (GRA) and the derived isothiocyanate sulforaphane (SFN), secondary metabolites occurring exclusively in Brassicales, on chemotherapy‐induced neuropathic pain. Mice were repeatedly treated with oxaliplatin (2.4 mg kg−1 ip) for 14 days to induce neuropathic pain. GRA and SFN effects were evaluated after a single administration on Day 15 or after a daily repeated oral and subcutaneous treatment starting from the first day of oxaliplatin injection until the 14th day. Single subcutaneous and oral administrations of GRA (4.43–119.79 μmol kg−1) or SFN (1.33–13.31 μmol kg−1) reduced neuropathic pain in a dose‐dependent manner. The repeated administration of GRA and SFN (respectively 13.31 and 4.43 μmol kg−1) prevented the chemotherapy‐induced neuropathy. The co‐administration of GRA and SFN in mixture with the H2S binding molecule, haemoglobin, abolished their pain‐relieving effect, which was also reverted by pretreating the animals with the selective blocker of Kv7 potassium channels, XE991. GRA and SFN reduce neuropathic pain by releasing H2S and modulating Kv7 channels and show a protective effect on the chemotherapy‐induced neuropathy.
A new approach to design efficient univariate control charts to monitor the process mean
Authors: Nawaz Tahir , Raza Muhammad Ali , Han Dong 
Published: August 2018

AbstractDesigning of efficient control charts for monitoring manufacturing processes and identifying assignable cause of variations is of constant interest in statistical process control. The present study incorporates neoteric ranked set sampling to design more efficient Shewhart, cumulative sum, and exponentially weighted moving average control charts for monitoring the mean of normal process. Using Monte Carlo simulations, the performance of the proposed charts is evaluated and compared with competing control charts on the basis of average run length and standard deviation of the run length for detection of shift of a specific magnitude. The extra quadratic loss is used to assess the overall performance of the control charts to detect shifts of various magnitudes. To further support the findings, a simulation study is carried out which revealed the supremacy of the proposed control charts over the existing charts. A real data set from a combined cycle power plant is used to demonstrate the application of the proposed control charts.
Magnesium‐Engineered Silica Framework for pH‐Accelerated Biodegradation and DNAzyme‐Triggered Chemotherapy
Authors: Yu Luodan , Chen Yu , Lin Han , Gao Shanshan , Chen Hangrong , Shi Jianlin 
Published: August 2018

AbstractInorganic nanocarriers have shown their high performance in disease theranostics in preclinical animal models and further great prospects for clinical translation. However, their dissatisfactory biodegradability and pre‐drug leakage with nonspecificity to lesion sites significantly hinders the possible clinical translation. To solve these two critical issues, a framework‐engineering strategy is introduced to simultaneously achieve enhanced biodegradability and controllable drug releasing, based on the mostly explored mesoporous silica‐based nanosystems. The framework of mesoporous silica is engineered by direct Mg doping via a generic dissolution and regrowth approach, and it can transform into the easy biodegradation of magnesium silicate nanocarriers with simultaneous on‐demand drug release. Such magnesium silicate nanocarriers can respond to the mild acidic environment of tumor tissue, causing the fast breaking up and biodegradation of the silica framework. More interesting, the released Mg2+ can further activate Mg2+‐dependent DNAzyme on the surface of hollow mesoporous magnesium silicate nanoparticles (HMMSNs) to cleave the RNA‐based gatekeeper, which further accelerates the release of loaded anticancer drugs. Therefore, enhanced anticancer efficiency of chemotherapeutic drugs assisted by the biodegradable intelligent HMMSNs is achieved. The high biocompatibility of nanocarriers and biodegradation products is demonstrated and can be easily excreted via feces and urine guaranteeing their further clinical translation.
In Situ Techniques for Developing Robust Li–S Batteries
Authors: Li Ming , Amirzadeh Zhila , De Marco Roland , Tan Xin Fu , Whittaker Andrew , Huang Xia , Wepf Roger , Knibbe Ruth 
Published: August 2018

AbstractRechargeable lithium–sulfur batteries (LSBs) are of great interest in the field of energy storage due to their favorable operational characteristics, for example, high theoretical energy density and low cost. However, LSBs are limited by long‐term degradation, caused by the dissolution of intermediate lithium polysulfide phases. Further improvement of LSBs requires an in‐depth understanding of the underlying redox reactions and active‐material degradation mechanisms. Advanced characterization techniques, especially in situ/in operando characterization tools, are used and developed in the field of LSBs to probe the rate‐limiting performance and design characteristics of functional materials. Here, common in situ/in operando techniques are reviewed with regard to recent research significance and practical limitations, with the aim of providing a comprehensive treatise on in situ characterization technique selection for LSBs, thereby allowing their future development and improvement.
P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis
Authors: Leeson Hannah C. , Kasherman Maria A. , Chan-Ling Tailoi , Lovelace Michael D. , Brownlie Jeremy C. , Toppinen Kelly M. , Gu Ben J. , Weible Michael W. 
Published: August 2018

AbstractIdentifying the signaling mechanisms that regulate adult neurogenesis is essential to understanding how the brain may respond to neuro-inflammatory events. P2X7 receptors can regulate pro-inflammatory responses, and in addition to their role as cation channels they can trigger cell death and mediate phagocytosis. How P2X7 receptors may regulate adult neurogenesis is currently unclear. Here, neural progenitor cells (NPCs) derived from adult murine hippocampal subgranular (SGZ) and cerebral subventricular (SVZ) zones were utilized to characterize the roles of P2X7 in adult neurogenesis, and assess the effects of high extracellular ATP, characteristic of inflammation, on NPCs. Immunocytochemistry found NPCs in vivo and in vitro expressed P2X7, and the activity of P2X7 in culture was demonstrated using calcium influx and pore formation assays. Live cell and confocal microscopy, in conjunction with flow cytometry, revealed P2X7+ NPCs were able to phagocytose fluorescent beads, and this was inhibited by ATP, indicative of P2X7 involvement. Furthermore, P2X7 receptors were activated with ATP or BzATP, and 5-ethynyl-2′-deoxyuridine (EdU) used to observe a dose-dependent decrease in NPC proliferation. A role for P2X7 in decreased NPC proliferation was confirmed using chemical inhibition and NPCs from P2X7−/− mice. Together, these data present three distinct roles for P2X7 during adult neurogenesis, depending on extracellular ATP concentrations: (a) P2X7 receptors can form transmembrane pores leading to cell death, (b) P2X7 receptors can regulate rates of proliferation, likely via calcium signaling, and (c) P2X7 can function as scavenger receptors in the absence of ATP, allowing NPCs to phagocytose apoptotic NPCs during neurogenesis.
COMPLAINING ABOUT LIVED SPACES: RESPONSES TO THE URBAN LIVING ENVIRONMENT OF NORTHERN SONG KAIFENG
Authors: Tsui Lik Hang 
Published: August 2018

AbstractThis article explores the understudied issue of urban problems in pre-modern China and examines the responses to the negative impact of urban development on life in the populous city of Kaifeng in the Northern Song (960–1127). Although writers, painters, and historians have portrayed the capital city's splendor for centuries, various urban problems emerged as medieval China became a more urbanized society. This article investigates Ouyang Xiu's (1007–1072) accounts of how extreme weather conditions adversely affected the lives of Kaifeng residents. These experiences, which he discussed in letters and poems, are associated with longer trends that result in climatic anomalies and disasters in the city. Ouyang Xiu also complained about living costs and medical services in Kaifeng. These reflect the difficulties in maintaining good urban provisions and services in a city of this scale.
Intranasal Helicobacter pylori infection in patients with chronic rhinosinusitis with polyposis
Authors: Siupsinskiene N , Katutiene I , Jonikiene V , Janciauskas D , Vaitkus S 
Published: August 2018

AbstractObjectiveTo determine the prevalence of Helicobacter pylori infection in nasal biopsy specimens from patients with chronic rhinosinusitis with polyposis versus control patients, and to assess the correlations between H pylori infection identified in the nasal tissue and patients’ sociodemographic data and reflux-related symptoms and signs.MethodsNasal biopsy samples were taken from 75 adult patients who underwent nasal surgery for chronic rhinosinusitis with polyposis (clinical group, n = 45) and a deviated septum (control group, n = 30). H pylori infection was identified using histochemical and rapid urease tests.ResultsThe prevalence of intranasal H pylori infection was significantly higher in the clinical group (28.9 per cent) compared to the control group (3.3 per cent) (p = 0.005). A significant yet weak association was found between positive H pylori status and laryngopharyngeal reflux related hypertrophy of the posterior commissure of the larynx. No other correlations reached statistical significance.ConclusionH pylori infection is potentially related to chronic rhinosinusitis with polyposis. Further research is needed to clarify the role of H pylori as a risk factor for the development of sinonasal diseases and to examine its link with laryngopharyngeal reflux.
Morphology and Ontogeny of Statoliths in the Grooved Carpet Shell, Ruditapes decussatus
Authors: Galante-Oliveira Susana , Pereira António , Baptista Tiago , Guimarães Fernanda , Soares Jorge , Lopes José Carlos , Machado Jorge , Barroso Carlos 
Published: August 2018

AbstractStatoliths are nonskeletal calcified structures included in most invertebrates’ gravireceptors. They have been identified and characterized in several gastropod and cephalopod molluscs and have proved to be very useful for age estimation, growth studies, and connectivity analysis, among other applications. Beyond the scarce available records on their occurrence in Class Bivalvia, statoliths are yet to be documented in the grooved carpet shell, Ruditapes decussatus, a species of high ecological and commercial value. An easy method for the extraction and processing of R. decussatus statoliths is described herein. The statolith growth was followed from the initial shell length (SL) of 2.5–3.5 mm (seed commercial size T1.5) for a period of 6 months in a nursery facility located in the Ria de Aveiro (an estuarine system in NW Portugal). The relationship between statolith diameter (StD) and SL follows the function StD=14.305 SL0.254 (N=173; r=0.855, p<0.001). All statoliths observed showed similar morphostructure and general chemistry: hard, translucent spheres of crystalline calcium oxalate (whewellite), with a central nucleus delimited by a growth check of 6.7±1.0 µm in diameter, possibly as a result of growth arrest during metamorphosis, a metamorphic ring, as described for their gastropod counterparts. Subsequent studies should validate this and will involve a search for the occurrence of additional checks that may potentially be present in older specimens and if they are, would open a new range of most promising applications for bivalve statoliths.
Development and identification of new syntheticT. turgidum–T. monococcumamphiploids
Authors: Li Hongyu , Liu Xiaojuan , Zhang Minghu , Feng Zhen , Liu Dengcai , Ayliffe Michael , Hao Ming , Ning Shunzong , Yuan Zhongwei , Yan Zehong , Chen Xuejiao , Zhang Lianquan 
Published: August 2018

AbstractTriticum monococcumssp.monococcumhas useful traits for bread wheat improvement. The synthesis ofTriticum turgidum–T. monococcumamphiploids is an essential step for transferring genes fromT. monococcuminto bread wheat. In this study, 264 wide hybridization combinations were done by crossing 60T. turgidumlines belonging to five subspecies with 83T. monococcumaccessions. Without embryo rescue and hormone treatment, from the 10,810 florets pollinated, 1983 seeds were obtained, with a mean crossability of 18.34% (range 0–89.29%). Many hybrid seeds (90.73%, 923/1017) could germinate and produce plants. A total of 56 new amphiploids (AABBAmAm) were produced by colchicine treatment ofT. turgidum×T. monococcumF1hybrids. The chromosome constitution of amphiploids was characterized by fluorescencein situhybridization using oligonucleotides probes with different chromosome and sub-chromosome specificities. Sodium dodecyl sulphate polyacrylamide gel electrophoresis analysis indicated that theGlu-A1m-b,Glu-A1m-c,Glu-A1m-dandGlu-A1m-hproteins ofT. monococcumwere expressed in some amphiploids. Despite resistance reduction in several cases, 45 out of 56 amphiploids exhibited resistance to the current predominant Chinese stripe rust races at both the seedling and adult plant stage. These novel amphiploids provide new germplasm for the potential improvement of bread wheat quality and stripe rust resistance.
Learning from interactions between the Milky Way and satellite galaxies
Authors: Ogiya Go 
Published: August 2018

AbstractThe Milky Way (MW) is interacting with its satellite galaxies and the tidal remnants of satellite galaxies have been observed especially in the MW halo. Understanding the spatial and velocity distributions of stars stripped from satellite galaxies will be of particular importance when interpreting the data from upcoming observations, such as Gaia, Subaru-HSC and PFS. We study tidal stripping events of satellite galaxies with various internal structures using high resolution N-body simulations. The dynamics of satellite galaxies is dominated by dark matter halos, but their density structure is still uncertain. The simulations reveal satellite galaxies with more tightly bound dark matter halos are more robust against the tidal force of the MW and have longer lifetimes than loosely bound ones (Ogiya et al., in prep.). Density scratches on the MW caused by the gravitational force of satellite galaxies and the observability are also discussed (Ogiya &amp; Burkert 2016).
The surface mass density in the solar neighbourhood using red clumps stars in TGASxRAVE
Authors: Hagen Jorrit H. J. , Helmi Amina 
Published: August 2018

AbstractWe investigate the kinematics of red clump stars in the Solar neighbourhood by combining data from the RAVE survey with the TGAS dataset presented in Gaia DR1. Our goal is to put new constraints on the (local) distribution of mass using the Jeans Equations. Here we show the variation of the vertical velocity dispersion as function of height above the mid-plane for both a thin and a thick disk tracer sample and present preliminary results.
Kinematics of the Milky Way disc from the RAVE survey combined with Gaia DR1
Authors: Robin Annie C. , Bienaymé Olivier , Fernández-Trincado José G. , Reylé Céline 
Published: August 2018

AbstractRelying on the complementarity of Gaia proper motions with radial velocities of the RAVE survey, we attempt to constrain the kinematics of the Milky Way disc. Based on the population synthesis model, we simulate the observations, applying the detailed selection functions of the observations. The dynamics is described using a global gravitational potential computed from the mass distribution of the population model, approximated by a Stäckel potential (Bienaymé et al. 2015). We explore a set of free parameters (solar motion, age - velocity dispersion of the disc as a function of age, the velocity gradients, vertex deviation) using a Markov Chain Monte Carlo method. We show that the fitted model reproduces very well the radial velocity and proper motion distributions, allowing to constrain the thin and thick disc secular evolution with time.
Origin of the Galactic Halo: accretion vs. in situ formation
Authors: Spitoni Emanuele , Vincenzo Fiorenzo , Matteucci Francesca , Romano Donatella 
Published: August 2018

AbstractWe test the hypothesis that the classical and ultra-faint dwarf spheroidal satellites of the our Galaxy have been the building blocks of the Galactic halo by comparing their [O/Fe] and [Ba/Fe] vs. [Fe/H] patterns with the ones observed in Galactic halo stars. The [O/Fe] ratio deviates substantially from the observed abundance ratios in the Galactic halo stars for [Fe/H] &gt; -2 dex, while they overlap for lower metallicities. On the other hand, for the neutron capture elements, the discrepancy is extended at all the metallicities, suggesting that the majority of stars in the halo are likely to have been formed in situ. We present the results for a model considering the effects of an enriched gas stripped from dwarf satellites on the chemical evolution of the Galactic halo. We find that the resulting chemical abundances of the halo stars depend on the adopted infall time-scale, and the presence of a threshold in the gas for star formation.
The CORAVEL Radial Velocity Data Base
Authors: Udry Stéphane , Marmier Maxime , Mayor Michel , Andersen Johannes , Nordström Birgitta 
Published: August 2018

AbstractFrom 1977 to 1999, thousands of accurate radial velocities in both hemispheres were made on a large variety of programmes with the two CORAVEL scanners. The data base of ~350000 individual observations will now be made available to complement the Gaia data.
Time evolution of the properties of gaps in stellar streams in axisymmetric potentials
Authors: Koppelman Helmer H. , Helmi Amina 
Published: August 2018

AbstractWe present here a model that allows us to predict the properties of gaps in stellar streams, and how these depend on the parameters of the encounters (satellite mass, size and relative velocity). Since the gaps we consider are created by dark matter satellites we hope to use our understanding to constrain the properties of dark matter.