bluuebunny/crossref_metadata_2025_split huggingface dataset:
Political network embeddedness and ecological innovation: Do absorptive capacity and dynamic capability have any influence?
Authors: Zhao Shuliang , Wang Ziye , Arkorful Vincent Ekow 
Published: November 2024

AbstractEcological innovation is an important conduit to realizing economic and environmental benefits. As such, improving enterprise ecological innovation performance has recently gained prominence. In this vein, the interaction between internal and external driving factors is key to influencing ecological innovation performance. Although existing studies underscore network embedding as one of the important external driving factors, research is lacking on the influence of the interaction mechanism between political network embedding and internal driving factors on enterprise ecological innovation performance. Therefore, by engaging social network theory and social capital theory, this paper proposes a moderated‐mediation model, with absorptive capacity as the mediator and dynamic capability as the moderator for an empirical investigation. Analyzing 302 items of survey data, the current study discusses the influence mechanism of political network embeddedness on enterprise ecological innovation performance. Regression results confirmed no significant correlation between political network embeddedness depth and enterprise ecological innovation performance. However, political network embeddedness breadth and absorptive capacity positively affected enterprise ecological innovation performance. Absorptive capacity partially mediated the relationship between political network embeddedness breadth and enterprise ecological innovation performance. Dynamic capability also moderated the relationship between absorptive capacity and enterprise ecological innovation performance. The study results expanded the internal mechanism of the relationship between political network embeddedness and enterprise ecological innovation performance, corroborating the imperativeness of external political network resources and internal capital such as absorptive capacity and dynamic capability to improve enterprise ecological innovation performance.
Dual CD47 and PD‐L1 blockade elicits anti‐tumor immunity by intratumoral CD8+ T cells
Authors: Christo Susan N , McDonald Keely M , Burn Thomas N , Kurd Nadia , Stanfield Jessica , Kaneda Megan M , Seelige Ruth , Dillon Christopher P , Fisher Timothy S , Baaten Bas , Mackay Laura K 
Published: November 2024

AbstractObjectivesBispecific antibodies targeting CD47 and PD‐L1 (CD47 × PD‐L1 BisAb) demonstrate efficacy against a range of solid cancers. While dual blockade negates anti‐CD47‐mediated toxicity, the effect of combined innate and adaptive immune activation on protective tumor‐resident CD8+ T cells has yet to be fully elucidated.MethodsCD8+ T cell populations were tracked upon CD47 × PD‐L1 BisAb treatment in an orthotopic model of murine breast cancer where anti‐tumor immunity is mediated by CD8+ T cells. Immune responses were also compared with anti‐PD‐L1 monotherapy to assess the advantage of dual checkpoint targeting.ResultsWe found that CD47 × PD‐L1 BisAb treatment augmented CD8+ T cell responses in tumors, which resulted in enhanced tumor control. Compared with anti‐PD‐L1 treatment, dual CD47 and PD‐L1 blockade promoted greater numbers of antigen‐specific tumor‐resident CD8+ T cells that exhibited increased cytokine production.ConclusionsEngagement of innate and adaptive immune checkpoint molecules via CD47 × PD‐L1 BisAb treatment resulted in robust CD8+ T cell responses, including the induction of tumor‐resident CD8+ T cells that exhibited functionally superior anti‐tumor immunity. These results demonstrate that innate immune activation potentiates anti‐tumor adaptive responses, highlighting the use of dual checkpoint blockade as an optimal strategy for promoting CD8+ T cell‐mediated protection.
Anatomy of modern sedimentary volcanoes produced by gas‐charged groundwater liquefaction, Lake Powell, Hite, Utah: Implications for the recognition and interpretation of ancient sedimentary volcanoes
Authors: Wizevich Michael C. , Simpson Edward L. , Underwood Abigail , Sherrod Laura , Livingston Kelsey , Bogner Emily , Malenda Margariete 
Published: November 2024

AbstractNumerous sedimentary volcanoes, recently exposed on the Colorado River delta surface at Lake Powell near Hite, Utah, were generated by sediment slurries propelled by gas, mainly microbially generated methane (CH4). Two sedimentary volcanoes were excavated, one in 2016 and the other in 2019, in order to characterise the internal structures. Comparison of the internal structures of these features with those of previously documented seismic‐generated sedimentary volcanoes helps in differentiating the various modes of mobilised sediment generation. Sedimentary volcanoes are commonly employed as tools in palaeoseismic reconstruction, thus it is important to establish criteria to differentiate non‐seismic‐generated sedimentary volcanoes and accompanying sediment deformation from those features generated by earthquakes. Trenches through the volcanoes and immediate subsurface areas reveal a complex cone stratigraphy of centimetre‐scale graded sand‐silt laminations and clastic dikes that cross‐cut the cone and sub‐cone (delta) sediment. Some cone strata have ripple cross laminations, a scoured base and are disrupted by soft‐sediment deformation. In the 2016 volcano, the lowest 0.5 m of the dikes exposed in the trench are filled with organic‐rich mud, but these conduits are empty nearer to the surface as a result of sediment settling after eruption cessation. The 2019 sedimentary volcano differs from the other by: (1) more cross laminations in the cone, (2) collapse structures surrounding the crater, (3) a relatively simple plumbing system assisted by desiccation‐generated fissures and (4) a massive sediment infill of the vent. Both complex internal cone stratigraphy and the two distinct cross‐cutting dike‐conduit systems, unequivocally generated by recurrent gas and water discharge, add to the database of features for non‐seismic‐generated sedimentary volcanoes. This array of sedimentary structures from a non‐seismic‐generated sedimentary volcano demonstrates that certain features, including numerous internal laminations composing the cone and complex generations of dike systems are not unique to seismic‐generated sand volcanoes.
Urban climatological research informing environmental policy and planning in Fukuoka, Japan: What makes an epistemic community successful locally?
Authors: Mabon Leslie , Machoň Miloslav 
Published: November 2024

AbstractInterest in knowledge politics driving urban environmental policy is growing. The aim of this paper is to assess the conditions that enable an epistemic community of experts to influence policy in a specific locality. We evaluate an epistemic community of urban climatology researchers in Fukuoka, Japan, who have successfully engaged with local policy despite documented knowledge circulation failures for urban climatology elsewhere. The research is based on a process tracing‐derived methodology, analysing archival and documentary sources. Its results show the epistemic community has conducted observational and modelling‐based research in Fukuoka over decades, networking with peers across Japan and globally and making recommendations for policy interventions locally through government expert committees and collaborative projects. These findings reflect the importance of professionalisation and modes of persuasion – especially visuals, such as maps showing heat islands – in explaining how epistemic communities come to be effective. We argue, however, that institutions constitute epistemic communities as well as individuals. The conclusions display, however, that even if an epistemic community is effective in influencing policy, this will not necessarily translate into practical interventions in the built environment. Understanding how epistemic communities define and measure their own ‘success’ is thus an area for future research.
Phytochemical Profiling, Acute Toxicity, and Hepatoprotective Effects of Anchusa Limbata in Thioacetamide‐Induced Liver Cirrhosis in Rats
Authors: Abdul‐Aziz Ahmed Khaled , Jabbar Ahmed A. J. , Raouf Mohammed M. Hussein M. , M. Al‐Qaaneh Ayman , Rizgar Hassan Rawaz , Ismael Salih Musher , Mothana Ramzi A. , Abdulaziz Al‐Hamoud Gadah , Ameen Abdulla Mahmood , Hasson Sidgi , Abdul‐samad Ismail Parween 
Published: November 2024

ABSTRACTEvaluation of Anchusa species of the family Boraginaceae during previous investigations determined numerous therapeutic potentials against inflammatory‐related diseases. The present study evaluates the phytochemical, acute toxicity, and hepatoprotective effects of methanolic extracts of Anchusa limbata (MEAL) against thioacetamide (TAA)‐induced liver injury in rats. The phytochemical profiling of MEAL followed a Folin–Ciocalteu and 10% AlCl3 procedure using a spectrophotometer. Thirty rats were divided into 5 groups: Normal (A) and TAA control rats (B) treated orally with daily 10% tween 20; reference rats (C) received daily oral dose of 50 mg/kg silymarin; (D and E) rats received daily doses of 250 and 500 mg/kg MEAL, respectively. In addition, group B‐E received 3 injections of 200 mg/kg TAA weekly for 60 days. The phytochemical profiling showed increased polyphenolic (129.2 mg gallic acid equivalent/g) and flavonoid (105.3 mg quercetin equivalent/g extract) contents in MEAL. The TAA intraperitoneal injection caused significant hepatic dysfunctionality (lowered total protein, 54.7 g/L; albumin levels, 7.8 g/L), hepatotoxicity, and necrotized cell proliferation. TAA hepatotoxicity resulted in an increased expression of proliferating cell nuclear antigen (PCNA), TGF‐β1 tissue expression, liver enzymatic leakage, and oxidative stress biomarkers, while it reduced pro‐apoptotic Bcl‐2–associated X protein (Bax) proteins and inflammatory mediators (TNF‐α and IL‐6) and increased IL‐10. Conversely, MEAL treatment ameliorated the TAA‐induced hepatotoxicity and restored liver functions. The present hepatoprotectives of MEAL could be attributed to its increased polyphenolic and flavonoid contents, which require further isolation and identification of molecules underlying such therapeutic actions.
Ibrutinib With Bendamustine and Rituximab for Treatment of Patients With Relapsed/Refractory Aggressive B‐Cell Lymphoma
Authors: Kedmi Meirav , Ribakovsy Elena , Benjamini Ohad , Schiby Ginette , Barshack Iris , Raskin Stephen , Eshet Yael , Mehr Ramit , Horowitz Netanel , Gurion Ronit , Goldschmidt Neta , Perry Chava , Levi Itai , Aviv Ariel , Herzog‐Tzarfati Katrin , Nagler Arnon , Avigdor Abraham 
Published: November 2024

ABSTRACTTherapy for relapsed or refractory (R/R) aggressive B‐cell non‐Hodgkin lymphoma (aB‐NHL) post autologous stem cell transplantation (ASCT) or in elderly patients can be challenging. In this single‐center, single‐arm, phase II clinical study, we investigated the efficacy of ibrutinib (560 mg once daily) in combination with bendamustine and rituximab (IBR) given for six 28‐day cycles in their standard dose, to patients with R/R aB‐NHL who were either transplant ineligible in first or second relapse or post‐ASCT for second relapse. The primary endpoint was overall response rate (ORR). Fifty‐six patients (54% male, median age 69.7 years) were included. ORR was 49.1% among 55 patients treated with ≥ 1 cycle of IBR and 69.4% among 36 patients treated with ≥ 3 cycles. Patients with relapsed disease had significantly higher ORR compared to those with refractory disease (72.3% vs. 37.8%, p = 0.024). Median overall survival (OS) was 11.6 months (95% CI, 7.1–22.3) and median progression‐free survival was 5.3 months (95% CI, 2.5–7.4). Patients with complete and partial responses had significantly longer median OS compared to those with stable and progressive disease (28.1 vs. 5.2 months, p < 0.0001). Adverse events included thrombocytopenia (19.6%), anemia (16.1%), neutropenia (7.1%), fatigue (35.7%), diarrhea (28.6%) and nausea (28.6%). At the first efficacy evaluation 8 patients were referred to transplantation, and 3 more were referred during follow‐up. These data indicate that the IBR regimen is a safe and effective treatment option that can also be used for bridging to transplantation in patients with R/R aB‐NHL.Trial Registration: ClinicalTrials.gov: NCT02747732
Distribution and Caching of English Speech Corpus Based on 5G
Authors: Huang Chenlu 
Published: November 2024

ABSTRACTWith the rapid development of 5G technology, more and more applications are emerging, such as online video platforms, live streaming applications, online education, and remote conferences. The key of these applications is the data distribution and caching. This paper mainly focuses on the English speech corpus distribution and caching in online education. In order to avoid the potential congestion and delay in the cloud server, this paper deploys the content delivery network at edge‐cloud server instead. When the requested English speech corpus is stored in the edge server, it is sent to the user directly; otherwise, the edge server request the file from cloud server. Compared with cloud content delivery network (CCDN), the proposed scheme can significantly reduce the congestion and delay during English speech corpus distribution in online education.
Momentary Fluctuations in Impulsivity Predicts Suicidal Ideation Among Those With Problematic Alcohol Use
Authors: Ammerman Brooke A. , Knorr Anne C. , McClure Kenneth , O'Brien Connor , Xu Irene 
Published: November 2024

ABSTRACTBackgroundProblematic alcohol use is a recognized risk factor for suicidal thoughts and behaviors. Individuals who misuse alcohol and those experiencing suicidal ideation (SI) often exhibit elevated impulsivity, suggesting that impulsivity may be an underlying mechanism. Impulsivity fluctuates considerably within individuals over short periods, particularly among those engaged in episodic heavy drinking, college students, and those with SI. While impulsivity is associated with suicidal thinking at a trait level, its relationship with SI on a momentary level remains relatively unexplored. This study aimed to (a) replicate cross‐sectional findings linking impulsivity and SI in those with problematic alcohol use, and (b) extend these findings to examine the momentary associations between impulsivity and SI within this population.MethodTwo independent undergraduate samples were utilized: the first cross‐sectional (n = 653) and the second employing ecological momentary assessment (n = 56). All participants screened for problematic alcohol or substance use.ResultsOur results show a unique association between the impulsivity facet of negative urgency and SI. Results also demonstrate an interactive effect of negative affect and “spur of the moment decisions” in predicting concurrent SI, as well as an interaction between negative affect and “saying things without thinking” in prospectively predicting SI.ConclusionsFindings highlight the saliency of negative urgency, both at the trait and state level in the prediction of SI. Although in need of replication, results indicate that specific aspects of momentary impulsivity may be uniquely linked with SI, and that this relationship may be context dependent.
Accelerated Characteristic Mode Calculation for PEC Objects Using ACA‐QR‐SVD Algorithm
Authors: Zhang Pengfei , Huang Shaode , Zhang Jiejun , Zhou Jianhua , Hong Tao 
Published: November 2024

ABSTRACTCharacteristic mode (CM) analysis serves as a powerful tool for evaluating the radiation and scattering characteristics of objects. CM formulations within the method of moments (MoM) framework are widely favored due to their ability to offer clear physical insights, handle complex shapes, and facilitate straightforward implementation. However, MoM‐based CM formulations become inefficient when applied to electrically large objects due to the dense matrices involved. This article introduces a novel approach using a fast low‐rank decomposition‐based implicitly restarted Arnoldi method (IRAM) to accelerate CM computations. The adaptive cross approximation (ACA) and QR‐SVD algorithms are employed to efficiently compute the low‐rank decomposition of matrices. The ACA‐QR‐SVD algorithm offers advantages in matrix filling, LU factorization, and matrix–vector multiplication processes, thereby enhancing efficiency. Numerical simulations on two representative objects demonstrate that the proposed algorithm notably improves computational speed and reduces memory requirements while maintaining high computational accuracy.
Impact of the Indo‐Pacific Warm Pool Warming on Indian Summer Monsoon Rainfall Pattern
Authors: Yadav Ramesh Kumar 
Published: November 2024

ABSTRACTThe Indo‐Pacific warm pool (IPWP), enclosed by a 28°C isotherm, is vital in controlling atmospheric circulations affecting monsoonal flow. The warming trend of sea surface temperatures (SSTs) over the IPWP has expanded the IPWP region. This study examines the impact of the IPWP warming on the Indian summer monsoon rainfall (ISMR) patterns using ERA5 reanalysis and India Meteorological Department rainfall records based on station data from 1959 to 2021. Analyses based on correlation, regression and composite anomalies show the complex relationship between recent decades of IPWP expansion/warming and monsoon circulation. However, the effects of regional IPWP SST warming changes on the ISMR pattern remain unexplored. Here, we explore the changes in the monsoonal circulation owing to the warming and expansion of IPWP, by comparing two equal periods (1959–1989 and 1990–2021). The responses of monsoons to IPWP warming in these two periods revealed some interesting facts, but the complexity remained. Further, we examined the composite impacts of IPWP SST warming in three categories, that is, very cool, usual and extremely warm, on the dynamics of monsoon circulations. The very cool IPWP is associated with the dry monsoon, while the extremely warm IPWP produces copious rainfall over southern India and dryness over eastern north India. The study confirms the non‐linear relationship between IPWP warming and ISMR, which has been investigated in detail.
Handgrip strength and health outcomes in hospitalized children or children with chronic disease: A systematic review
Authors: Verbrugghe Liesbet , Larue Alice , Delcourt Hanne , Vandenplas Yvan , Huysentruyt Koen 
Published: November 2024

AbstractHandgrip strength (HGS) is a simple measurement of maximum voluntary muscle strength and is widely used as a single indicator of overall muscle strength. This systematic review summarized the evidence about the relation between HGS and health outcomes in hospitalized children or chronically ill children. The primary outcome was the number of hospital days in a 2‐month period for outpatients and the length of hospital stay for inpatients. After a systematic search in PubMed, Embase, Lilacs, and the Cochrane Library, 9282 unique papers were screened, 24 included. Studies assessed HGS in children with cystic fibrosis, neuromuscular disease, chronic kidney disease, type 1 diabetes mellitus, asthma, cardiac disease, juvenile idiopathic arthritis, intestinal failure, surgical patients, and a mixed hospitalized population. One study reported that children experienced a decline in HGS during hospitalization which was associated with prolonged hospital stay. Another reported no relation with the number of hospital days in 5 years. No studies reported on the association between HGS and infectious complications or antibiotic use. We did find a positive correlation between HGS and quality of life, different nutritional parameters and inflammatory biochemical markers. We concluded that the relation between HGS and hospital stay in children is poorly studied. HGS showed promise as a functional biomarker for children with chronic health conditions when inflammation is involved, but more attention should be paid to the methodological aspects of assessing HGS.
Oncoplastic Surgery: Where Are We Now?
Authors: Clark Patricia , DiPasquale Ashley , Cocco Daniela , Brown Andrew , Brown Ashley 
Published: November 2024

ABSTRACTIn the 1970s, we learned breast conservation therapy (BCT) was not inferior to mastectomy. Early BCT methods could result in deformities that were unacceptable to patients and to their surgeons. By the 1990s, surgeons began to apply the principles of plastic surgery to improve outcomes. The term oncoplastic surgery was first described in the 1990s by Werner Audretsch. We offer a review of principles, techniques, current controversies, and challenges in broadening the utilization of OPS.
Analysis of Risk Factors, Treatment Patterns, and Survival Outcomes After Emergency Presentation With Colorectal Cancer: A Prospective Multicenter Cohort Study in Nigeria
Authors: Aderibigbe Adeniyi S. , Dare Anna J. , Kalvin Hannah L. , Olasehinde Olalekan , Wuraola Funmilola , Adisa Adewale , Omisore Adeleye Dorcas , Komolafe Akinwumi O. , Omoyiola Oluwatosin Zainab , Okereke Chukwuma Eze , Katung Aba , Egberoungbe Adedeji , Ariyibi Olufemi , Olatoke Samuel Adegboyega , Adeyeye Ademola Adetoyese , Agodirin Sulaiman Olayide , Bojuwoye Matthew Olumuyiwa , Fayenuwo James Oluwaleke , Ademakinwa Oluwabusayomi Roseline , Osinowo Dapo , Lawal Abdul‐Razak , Abdulkareem Fatimah B. , Goldman Debra , Knapp Gregory , Murthy Shilpa , Kahn Rivka , Gonen Mithat , Kingham T. Peter , Alatise Olusegun I. ,   For the African Research Group in Oncology Colorectal Cancer Working Group
Published: November 2024

ABSTRACTBackground and ObjectivesProspective data on presentation and outcomes of colorectal cancer (CRC) in Nigeria are limited; however, emergency presentation with advanced disease is thought common.MethodsConsecutive CRC patients presenting at six sites over 6 years were included. Risk factors for emergency presentation were evaluated using logistic regression methods. Overall survival (OS) was compared between emergent and elective patients using Kaplan‐Meier methods and the log‐rank test.ResultsOf 535 patients, 30.7% presented emergently. Median age was 56 years, 55% were men, and 5.0% reported a cancer family history. Emergency patients had more proximal cancers (42.1% vs. 24.0%), Stage IV disease (61.6% vs. 40.2%; p < 0.001), lower household income (₦35 000/month vs. ₦50 000/month), lower education levels (p = 0.008) and accessed care with nonmotorized transport (50.6% vs. 37.2%; p = 0.005). Median OS was shorter in the emergency group (6.4 vs. 17.4 months; p < 0.001). Across clinical stages, emergency presentation was associated with worse OS (Stage IV median OS 4.8 vs. 9.4 months; p = 0.002). Surgery improved survival in both groups, although emergency patients had higher 30‐day postoperative mortality (23.2% vs. 9.1%; p < 0.001).ConclusionsEmergent Nigerian CRC patients have worse OS than elective patients. Cancer control efforts should focus on faster cancer detection, early presentation, diagnosis, and treatment.