bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penyuluhan Keselamatam Pelayaran dan Perawatan pada Mesin Tempel Bagi Nelayan di Pesisir Pantai Gandoriah Pariaman
Authors: Sarifuddin Sarifuddin , Syamsyir Syamsyir , Erlinda Nelfi , Yatno Langandrinsyah Dwi , Devin Hasri 
Published: December 2024

Kegiatan ini kita dapat mengingatkan kesadaran masyarakat tentang manfaat keselamatan pelayaran dan perawatan mesin tempel khususnya di daerah Pesisir Pantai Gandoriah Pariaman. Melalui survei yang dilakukan, dapat diidentifikasi bahwa penyuluhan mengenai Keselamatan Pelayaran dan Perawatan pada Mesin Tempel memberikan hasil yang sangat bermanfaat, ini dapat dari hasil analisis angket yang disebarkan kepada peserta pengabdian diperoleh nilai 86,4 dengan kriteria sangat bermanfaat. Dan pada kegiatan ini para peserta juga samgat besungguh-sungguh mengikuti penyuluhan yang diberikan, ini dilihat dengan banyaknya pertanyaan-pertanyaan yang muncul dari peserta. Dan melalui kegiatan ini juga pengetahuan dan keterampilan masyarakat tentang cara menggunakan life jacket untuk penyelamatan diri dan perawatan mesin tempel yang merupakan salah satu metode untuk keselamatan dan perawatan jadi meningkat. Dengan pemahaman keselamatan dan perawatan ini diharapkan masyarakat sudah dapat mengatasi permasalahan yang yang sering terjadi pada saat melakukan penangkapan ikan di laut. Sehingga hasil dari tangkapan ikan dapat berdampak langsung terhadap ekonomi keluarga dan masyarakat setempat serta Kabupaten Pariaman pada umumnya.
CFIUS-Investitionskontrollverfahren unter FIRRMA 2018 und deutsche M&A-Praxis
Authors: Seibt Christoph H. , Koldehofe Jan-Willem 
Published: December 2024

Zusammenfassung
Das CFIUS-Investitionskontrollverfahren wurde durch den Foreign Investment Risk Review Modernization Act of 2018 (- FIRRMA 2018) sowie weitere Änderungen auf Verordnungsebene deutlich ausgeweitet und verschärft, wodurch sich die schon zuvor bestehenden Risiken sowie die Rechtsunsicherheit für die M&A-Praxis weiter erhöht haben. Dies gilt insbesondere bei Investitionen in Schlüsseltechnologien wie etwa Mikroelektronik, künstliche Intelligenz, Biotechnologie, Quantentechnik oder erneuerbare Energien. Fälle wie die gescheiterte Übernahme der deutschen AIXTRON SE (2016) sowie die - von CFIUS freigegebene, aber letztlich auch gescheiterte - Übernahme der Siltronic AG (2021/22) zeigen, dass selbst Transaktionen der CFIUSÜberprüfung unterliegen können, bei denen die Zielgesellschaft ihren Hauptsitz nicht in den USA hat. Angesichts der durch die Reformen weiter zugenommenen Bedeutung der US-Investitionskontrolle für die deutsche Transaktionspraxis soll der vorliegende Beitrag - im Wechselblick zum deutschen Außenwirtschaftsrecht - die Reichweite sowie den Ablauf des CFIUS-Verfahrens unter dem FIRRMA 2018 beleuchten sowie dessen Auswirkungen auf die deutsche M&A-Praxis analysieren. In diesem Rahmen soll auch auf die zukünftige Outbound-Investitionskontrolle der USA für Investitionen in China eingegangen werden, die das CFIUS-Regime künftig ergänzen wird, und ein Ausblick auf weitere Entwicklungen geworfen werden.
Nusinersen in type 1 spinal muscular atrophy: Twelve‐month real‐world data
Authors: Pane Marika , Coratti Giorgia , Sansone Valeria A. , Messina Sonia , Bruno Claudio , Catteruccia Michela , Sframeli Maria , Albamonte Emilio , Pedemonte Marina , D'Amico Adele , Bravetti Chiara , Berti Beatrice , Brigati Giorgia , Tacchetti Paola , Salmin Francesca , de Sanctis Roberto , Lucibello Simona , Piastra Marco , Genovese Orazio , Bertini Enrico , Vita Giuseppe , Tiziano Francesco Danilo , Mercuri Eugenio ,   on behalf of the Italian Expanded Access Program Working Group
Published: June 2019

ObjectiveThe aim of the study was to report 12‐month changes after treatment with nusinersen in a cohort of 85 type I spinal muscular atrophy patients of ages ranging from 2 months to 15 years and 11 months.MethodsAll patients were assessed using the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) and the Hammersmith Infant Neurological Examination‐Section 2 (HINE‐2).ResultsTwo of the 85 patients had 1 SMN2 copy, 61 had 2 copies, and 18 had 3 copies. In 4 patients the SMN2 copy number was not available. At baseline, the mean CHOP INTEND scores ranged between 0 and 52 (mean = 15.66, standard deviation [SD] = ±13.48), and the mean HINE‐2 score was between 0 and 5 (mean = 0.69, SD = ±1.23). There was a difference between baseline and the 12‐month scores on both the CHOP INTEND and the HINE‐2 for the whole group (p < 0.001), the subgroups with 2 SMN2 copies (p < 0.001), and those with 3 SMN2 copies (p < 0.001). The difference was found not only in patients younger than 210 days at baseline (p < 0.001) but also in those younger than 5 years on the CHOP INTEND and younger than 2 years on the HINE‐2.InterpretationOur results, expanding the age range and the severity of type I patients treated with nusinersen over 1 year, provide additional data on the range of efficacy of the drug that will be helpful in making an informed decision on whether to start treatment in patients of different ages and severity. ANN NEUROL 2019;86:443–451
AgNP/crystalline PANI/EBP‐composite‐based supercapacitor electrode with internal chemical interactions
Authors: Kim Hyungjoo , Ramalingam Manivannan , Balakumar Vellaichamy , Zhang Xiangwu , Gao Wei , Son Young‐A , Bradford Philip D. 
Published: June 2019

ABSTRACTIn this article, polyaniline (PANI) was conformally coated on epoxide‐functionalized buckypaper (EBP). Because of the presence of epoxide functional groups, chemical interactions occurred between oxygen in the epoxide groups and NH in the PANI. These chemical interactions were identified by peak shifts and intensity changes in Raman spectra. Additionally, crystalline peaks were clearly observed through X‐ray diffraction. However, Raman peak changes or crystalline peaks were not observed in nonfunctionalized buckypaper (purified pristine buckypaper [PPBP])‐based composites. Both hydrogen bonding and crystalline nature of EBP‐PANI enhanced its electrical conductivity, producing a specific capacitance better than that of PPBP‐PANI. Finally, Ag nanoparticles (AgNPs) were applied to EBP‐PANI to further enhance its electrical conductivity. Owing to the presence of AgNPs and their interactions with the N in PANI, the specific capacitance of EBP‐PANI‐AgNP reached 915.62 F/g. These results emphasize the positive effect of chemical interactions and crystalline nature of EBP‐based composites on their electrochemical performance. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48164.
New perspective on the benefits of the gene–environment independence in case–control studies
Authors: Luo Hao , Cohen Freue Gabriela V. , Zhao Xin , Bouchard‐Côté Alexandre , Burstyn Igor , Gustafson Paul 
Published: June 2019

AbstractWe study the benefit of exploiting the gene–environment independence (GEI) assumption for inferring the joint effect of genotype and environmental exposure on disease risk in a case–control study. By transforming the problem into a constrained maximum likelihood estimation problem we derive the asymptotic distribution of the maximum likelihood estimator (MLE) under the GEI assumption (MLE‐GEI) in a closed form. Our approach uncovers a transparent explanation of the efficiency gained by exploiting the GEI assumption in more general settings, thus bridging an important gap in the existing literature. Moreover, we propose an easy‐to‐implement numerical algorithm for estimating the model parameters in practice. Finally, we conduct simulation studies to compare the proposed method with the traditional prospective logistic regression method and the case‐only estimator. The Canadian Journal of Statistics 47: 473–486; 2019 © 2019 Statistical Society of Canada
Independent association between the visceral adiposity index and microalbuminuria in patients with newly diagnosed type 2 diabetes
Authors: Wen Jia , Yuan Hong 
Published: June 2019

AbstractAimsVisceral adiposity and albuminuria are commonly observed in patients with type 2 diabetes mellitus (T2DM). Recently, the visceral adipose index (VAI) was found to be an indicator of visceral fat accumulation. However, the relationship between the VAI and urinary albumin has not been investigated in T2DM patients, and whether the predictive value of the VAI is superior to that of the triglyceride/high‐density lipoprotein cholesterol (TG/HDL‐c) ratio remains unknown.Materials and methodsThree hundred and forty one newly diagnosed T2DM patients were enrolled. The anthropometric parameters, blood pressure, glucose, lipid profiles, urinary albumin, and other biochemical indices were examined. Linear and logistic regression models were developed to assess the association between the VAI and urinary albumin.ResultsThe prevalence of microalbuminuria was 41.3% (n = 141) and increased with increasing levels of VAI. An age‐adjusted partial correlation analysis showed that the VAI and TG/HDL‐c ratio were significantly associated with the waist‐to‐hip ratio, heart rate, total cholesterol, low‐density lipoprotein cholesterol, and uric acid. In the stepwise linear regression analysis, the VAI (β = .21, .009) and TG/HDL‐c (β = .25, .002) were significant determinants of urinary albumin. Moreover, in the multiple logistic regression model, the odds ratio (OR) of microalbuminuria per one SD increase in the VAI was 1.94 (95% CI, 1.11‐3.38), and a similar result was observed with a higher TG/HDL‐c ratio (OR = 2.03, 95% CI, 1.13‐3.65).ConclusionWe are the first to show a clear association between the VAI and urinary albumin in Chinese type 2 diabetic patients. Additionally, the VAI and TG/HDL‐c ratio had similar predictive power regarding albuminuria risk. The VAI could be a rapid and reliable tool for assessing early‐stage renal damage in newly diagnosed T2DM patients.
Thyroid hormone coordinates developmental trajectories but does not underlie developmental truncation in danionins
Authors: Hu Yinan , Mauri Angela , Donahue Joan , Singh Rajendra , Acosta Benjamin , McMenamin Sarah 
Published: June 2019

AbstractBackgroundDifferences in postembryonic developmental trajectories can profoundly alter adult phenotypes and life histories. Thyroid hormone (TH) regulates metamorphosis in many vertebrate taxa with multiphasic ecologies, and alterations to TH metabolism underlie notable cases of paedomorphosis in amphibians. We tested the requirement for TH in multiple postembryonic developmental processes in zebrafish, which has a monophasic ecology, and asked if TH production was compromised in paedomorphic Danionella.ResultsWe showed that TH regulates allometric growth in juvenile zebrafish, and inhibits relative head growth. The lateral line system showed differential requirements for TH: the hormone promotes canal neuromast formation and inhibits neuromast proliferation in the head, but causes expansion of the neuromast population in the trunk. While Danionella morphology resembled that of larval zebrafish, the two Danionella species analyzed were not similar to hypothyroid zebrafish in their shape or neuromast distribution, and both possessed functional thyroid follicles.ConclusionsAlthough zebrafish do not undergo a discrete ecological transformation, we found that multiple tissues undergo transitions in developmental trajectories that are dependent on TH, suggesting the TH axis and its downstream pathways as likely targets for adaptation. Nonetheless, we found no evidence that evolutionary paedomorphosis in Danionella is the result of compromised TH production.
Late effects of chemo and radiation treatment on dental structures of childhood cancer survivors. A systematic review and meta‐analysis
Authors: Seremidi Kyriaki , Kloukos Dimitrios , Polychronopoulou Argy , Kattamis Antonis , Kavvadia Katerina 
Published: June 2019

AbstractBackgroundThis systematic review summarizes the prevalence of dental defects after chemo and radiation therapy and correlates the findings with specific characteristics of each treatment modality.MethodsDatabase search was performed for studies reporting dental late effects of chemo and radiation therapy. After data extraction and risk of bias assessment, prevalence of crown and root defects was assessed. Correlations between each defect and the characteristics of the antineoplastic treatment were performed.ResultsSixteen nonrandomized studies were included, yielding a total of 1300 patients with a mean age at diagnosis of 4.5 years. Results reported that root defects were more common than crown defects. The most common root defect was impaired root growth and microdontia the most common crown defect. Age, radiation dose and field were statistically associated with higher prevalence of dental defects.ConclusionDefects were associated with combination of chemotherapy and radiotherapy, as used in current therapeutic antineoplastic modalities.
Successful laparoscopic resection of a paraganglioma immediately behind the inferior vena cava and bilateral renal veins
Authors: Hakariya Tomoaki , Shida Yohei , Ito Hidenori , Ueda Yasufumi , Kurata Hiroki , Ohtsubo Asato , Miyata Yasuyoshi , Sakai Hideki , Furusato Bungo 
Published: June 2019

IntroductionParagangliomas have a rich blood flow and are located around large vessels; thus, resection is often difficult. We herein report a case of a paraganglioma that was located immediately behind the inferior vena cava and bilateral renal veins and successfully resected by laparoscopic surgery.Case presentationA 72‐year‐old man was incidentally diagnosed with a 7‐cm retroperitoneal mass immediately behind the inferior vena cava and bilateral renal veins by computed tomography. The mass was diagnosed as a retroperitoneal paraganglioma. The patient underwent laparoscopic surgery in the left lateral decubitus position. The tumor was dissected completely with no complications.ConclusionResection of retroperitoneal paragangliomas is often a surgical challenge. The feasibility of the laparoscopic approach to such paragangliomas was demonstrated in the present case.
Mouse skeletal muscle creatine chemical exchange saturation transfer (CrCEST) imaging at 11.7T MRI
Authors: Takahashi Yusuke , Saito Shigeyoshi , Kioka Hidetaka , Araki Rikita , Asano Yoshihiro , Takashima Seiji , Sakata Yasushi , Yoshioka Yoshichika 
Published: June 2019

BackgroundCreatine chemical exchange saturation transfer (CrCEST) imaging is expected to be a novel evaluation method of muscular energy metabolism.PurposeTo develop CrCEST imaging of mouse skeletal muscle and to validate this technique by measuring changes in Cr concentration of ischemic hindlimbs.Study TypeProspective.Animal ModelC57BL/6 mice (n = 6), mild hindlimb ischemic mice (n = 6), and severe hindlimb ischemic mice (n = 6).Field Strength/SequenceMagnetic resonance angiography (MRA), CrCEST imaging, and phosphorus magnetic resonance spectroscopy (31P MRS) obtained at 11.7T.AssessmentMRA and 31P MRS were performed to confirm the presence of ischemia following the compression by rubber tourniquet. CrCEST imaging was performed and magnetization transfer ratio asymmetry (MTRasym), which reflects Cr concentration, and was calculated in severe ischemia models, mild ischemia models, and control mice. Follow‐up CrCEST imaging was performed after the release of ischemia in the mild ischemia models.Statistical TestsMean ± SD, one‐way analysis of variance (ANOVA) with Tukey's HSD test, unpaired or paired t‐test.ResultsMRA revealed the loss of blood flow of the femoral artery in the ischemic hindlimb. 31P MRS revealed different degrees of PCr decrease in severe and mild ischemic hindlimb (n = 3 per group, normal hindlimb: 1.0 ± 0, mild ischemic hindlimb: 0.77 ± 0.13, severe ischemic hindlimb: 0 ± 0). CrCEST imaging inversely revealed a significant stepwise increase in the MTRasym ratio of ischemic hindlimbs compared with controls (control, mild ischemia, and severe ischemia; 0.99 ± 0.04, 1.36 ± 0.08, and 1.59 ± 0.23, respectively, P < 0.0001). In addition, follow‐up CrCEST imaging after the release of ischemia revealed normalization of the MTRasym ratios (recovered hindlimb: 1.01 ± 0.05).Data ConclusionWe demonstrated an increase in the MTRasym of ischemic hindlimbs, along with a decrease of PCr. We demonstrated the normalization of MTRasym after the release of ischemia and developed CrCEST imaging of mouse skeletal muscle.Level of Evidence: 2Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2020;51:563–570.
Mesostructured cellular foam solid‐phase microextraction coating for the highly sensitive recognition of polychlorinated biphenyls in water samples
Authors: Wang Xuemei , Kou Haixia , Wang Juan , Du Tongtong , Teng Ruiju , Du Xinzhen , Lu Xiaoquan 
Published: June 2019

AbstractWe herein presented a mesoporous cellular foam solid‐phase microextraction coating that showed highly sensitive recognition for weakly polarity polychlorinated biphenyls in water samples. The mesoporous cellular foam coater fiber was for the first time prepared by a simple sol‐gel method. The main experimental parameters including extraction temperature, extraction time, desorption time, stirring rate, and ionic strength were investigated by high‐efficiency orthogonal array design, a L16 (44) matrix was applied for the identification of optimized extraction parameters, and the optimized method was successfully applied to the analysis of environmental water sample. The novel mesoporous cellular foam coated fibers exhibited sensitive limits of detection (0.07–0.28 µg/L), wide linearity (5–3000 µg/L), and good reproducibility (3.5–8.3% for single fiber, and 4.9–8.7% for fiber‐to‐fiber) for polychlorinated biphenyls. The home‐made coating was successfully used in the analysis of polychlorinated biphenyls in real environmental water samples. These results indicate that the synthesized mesoporous cellular foams are promising materials for adsorption and separation applications in sample pretreatment.
Analysis of MIR155HG variants and colorectal cancer susceptibility in Han Chinese population
Authors: Wu Huangfu , He Guisheng , Han Hua , Xiong Wei , Song Tao , Chen Huamin , Chen Xiuxiu , Wu Xiaoming , Huang Guangyue , Zhang Yazhen , Sun Chuanwei , Zhao Chaoyang , Chen Yunjing 
Published: June 2019

AbstractBackgroundMIR155HG plays an important role in malignant tumors, but it is rarely reported in the occurrence and development of colorectal cancer (CRC). This study investigated the effects of MIR155HG polymorphisms on CRC susceptibility from the perspective of molecular genetics.MethodsEight SNPs in MIR155HG were selected and genotyped among 514 CRC cases and 510 healthy controls using the Agena MassARRAY platform. The associations between these SNPs and the CRC risk were evaluated under genetic models using conditional logistic regression analysis. The HaploReg v4.1 database was used for SNPs functional prediction.ResultsThe allele “C” of rs12482371 (p = 0.047), allele “C” of rs1893650 (p = 0.025), and the allele “A” of rs928883 (p = 0.037) in MIR155HG were significantly associated with CRC risk. Genetic model analysis revealed that rs12482371 and rs1893650 increased CRC risk; whereas rs928883 was associated with reduced CRC risk. Stratification analysis showed that rs9383938 was a protective factor in CRC patients under 60 years old. Rs12482371 and rs1893650 were associated with the CRC risk in females. Rs11911469 and rs34904192 may affect the clinical stage and lymph node metastasis. Moreover, the haplotypes CTT and GTC of LD block rs4143370|rs77218221|rs12482371, and the haplotypes CATGA and CACGG of LD block rs77699734|rs11911469|rs1893650|rs34904192|rs928883 were significantly associated with CRC risk.ConclusionThis study revealed that MIR155HG SNPs were associated with CRC susceptibility and could be predictive biomarkers for CRC risk.
Fundamental solutions and asymptotic numerical methods for bifurcation analysis of nonlinear bi‐harmonic problems
Authors: Tri Abdeljalil , Askour Omar , Braikat Bouazza , Zahrouni Hamid , Potier‐Ferry Michel 
Published: June 2019

AbstractNew algorithms, combining asymptotic numerical method (ANM) and method of fundamental solutions, are proposed to compute bifurcation points on branch solutions of a nonlinear bi‐harmonic problem. Three methods, mainly based on asymptotic developments framework, are then proposed. The first one consists in exploiting the ANM step accumulation close to the bifurcation points on a solution branch, the second method allows the introduction of an indicator that vanishes at the bifurcation points, and finally the first real root of the Padé approximant denominator represents the third bifurcation indicator. Two numerical examples are considered to analyze the robustness of these algorithms.
Switchable cholesterol recognition system with Diels–Alder reaction using molecular imprinting technique on self‐assembled monolayer
Authors: Shin Min Jae , Kim Minhee , Shin Jae Sup 
Published: June 2019

AbstractMolecular imprinting was conducted using a method to form a polymeric coating on a self‐assembled monolayer (SAM). This molecular imprinting system was able to obtain an on–off function using the Diels–Alder reaction. Cholesterol was used as a target compound and the SAM was formed using thiol compound on a gold plate. Epoxy resin was used to form the polymeric coating. Covalent bonding method was used in molecular imprinting. The formed molecular imprinting system recognized cholesterol better than analogs of cholesterol. Epoxy resin curing agent with furan group was synthesized to form the molecular imprinting system. Using the Diels–Alder reaction between the furan group and phenylmaleimide, this molecular imprinting system offers a switchable function. © 2019 Society of Chemical Industry
Genetic dissection of cell wall defects and the strigolactone pathway in Arabidopsis
Authors: Ramírez Vicente , Pauly Markus 
Published: June 2019

AbstractDefects in the biosynthesis and/or deposition of secondary plant cell wall polymers result in the collapse of xylem vessels causing a dwarfed plant stature and an altered plant architecture termed irregular xylem (irx) syndrome. For example, reduced xylan O‐acetylation causes strong developmental defects and increased freezing tolerance. Recently, we demonstrated that the irx syndrome in the trichome birefringence‐like 29/eskimo1 (tbl29/esk1) mutant is dependent on MORE AXILLARY GROWTH 4 (MAX4), a key enzyme in the biosynthesis of the phytohormone strigolactone (SL). In this report, we show that other xylan‐ and cellulose‐deficient secondary wall mutants exhibit increased freezing tolerance correlated with the irx syndrome. In addition, these phenotypes are also dependent on MAX4, suggesting a more general interaction between secondary wall defects and SL biosynthesis. In contrast, MAX4 does not play a role in developmental defects triggered by primary wall deficiencies, suggesting that the interaction is restricted to vascular tissue. Through a reverse genetics approach, the requirement of different components of the SL pathway impacting the irx syndrome in tbl29 was evaluated. Our results show that the tbl29‐associated irx phenotypes are dependent on the MAX3 and MAX4 enzymes, involved in the early steps of SL biosynthesis. In contrast, this signaling is independent on downstream enzymes in the biosynthesis and perception of SL such as MAX1 and MAX2.