bluuebunny/crossref_metadata_2025_split huggingface dataset:
Edukasi Penerapan Budaya Risiko di Bumdes Pematang Serai Kabupaten Langkat
Authors: Sebayang Saimara , Delvi Yanti Eli , Taufik Mahful , Syukri Ilham 
Published: November 2024

Program Kemitraan Masyarakat ini bertujuan untuk meningkatkan pemahaman dan implementasi budaya risiko pada Badan Usaha Milik Desa (BUMDes) Pematang Serai di Kabupaten Langkat. Penerapan budaya risiko menjadi sangat penting mengingat BUMDes sebagai motor penggerak ekonomi desa perlu memiliki ketahanan dalam menghadapi berbagai risiko usaha. Metode pelaksanaan program ini dilakukan melalui serangkaian kegiatan edukasi yang meliputi pelatihan, pendampingan, dan workshop mengenai identifikasi risiko, penilaian risiko, serta strategi mitigasi risiko. Target khusus yang ingin dicapai adalah terbentuknya kesadaran pengurus dan anggota BUMDes akan pentingnya manajemen risiko, serta tersusunnya pedoman pengelolaan risiko yang sesuai dengan karakteristik usaha BUMDes Pematang Serai. Hasil dari program ini menunjukkan peningkatan pemahaman peserta terhadap konsep manajemen risiko sebesar 75%, terbentuknya tim pengelola risiko di tingkat BUMDes, serta tersusunnya dokumen manual manajemen risiko yang dapat diimplementasikan dalam operasional BUMDes. Program ini memberikan dampak positif dalam meningkatkan profesionalisme pengelolaan BUMDes dan memperkuat fondasi bisnis desa untuk pengembangan ekonomi masyarakat yang berkelanjutan.

This Community Partnership Program aims to improve the understanding and implementation of risk culture in Village-Owned Enterprises (BUMDes) Pematang Serai in Langkat Regency. The implementation of risk culture is very important considering that BUMDes as the driving force of the village economy needs to have resilience in facing various business risks. The method of implementing this program is carried out through a series of educational activities including training, mentoring, and workshops on risk identification, risk assessment, and risk mitigation strategies. The specific target to be achieved is the formation of awareness of BUMDes administrators and members of the importance of risk management, as well as the preparation of risk management guidelines that are in accordance with the characteristics of the Permatang Serai BUMDes business. The results of this program show an increase in participants' understanding of the concept of risk management by 75%, the formation of a risk management team at the BUMDes level, and the preparation of a manual risk management document that can be implemented in BUMDes operations. This program has a positive impact on improving the professionalism of BUMDes management and strengthening the foundation of village businesses for sustainable community economic development.
The Effect of Distance Learning on Technological Skills by English Language Teachers at Nablus Primary Governmental Schools
Authors: Majed Shkokani Yasmeen , Darmi Ramiaida , Suleiman Islaieh Abdelrahman Ibrahim , Abdelrazzaq Shkokani Riyad 
Published: November 2024

The study aimed at measuring the effect of distance learning on technological skills by English language teachers at Nablus primary governmental schools. It also determines the obstacles of technological skills during distance learning by English language teachers and suggests some appropriate solutions to these obstacles. To achieve the objectives of this study, the descriptive-analytical methodology was used. An online questionnaire was distributed to (231) teachers. The SPSS program was used to analyze the questionnaire data. The results showed a high degree of possessing technological skills by English language teachers during distance learning at Nablus primary governmental schools. According to the study results, the researchers recommended conducting further studies about technological skills during distance learning.
PENGANEKARAGAMAN SAYURAN DI UD OMAH SAYUR SENGKALING UNTUK MENINGKATKAN PELAYANAN PENJUALAN DI DESA MULYOAGUNG, KECAMATAN DAU KABUPATEN MALANG
Authors: Arifin Zainol , Gunawan Cakti Indra , Sasmito Cahyo , Suyani Ida Sugeng , Purwanto  
Published: November 2024

"UD Omah Sayur" is a company that markets various kinds of horticultural vegetables and staple foods, such as carrots, spinach, lettuce, onions, chilies, mustard greens, kale, and other vegetables. Starting from being an employee in someone's factory, then leaving and opening his own business, called Omah Sayur." is Mr. Nur Abdhiza. As the owner of the "UD Omah Sayur started developing "Omah Sayur" and played a direct role as the owner, while the others played roles as employees marketing the vegetables. Promotional media using the Internet is currently very relevant because people are used to looking for personal, company, or agency needs using Internet media. Surveys prove that 50% of home businesses or small and medium businesses already use the Internet as a promotional medium.
Prevalence and structure of calls from the Moscow emergency medical team to children with stroke
Authors: Khachaturov Y. A. , Plavunov N. F. , Vlasov P. N. , Sidorov A. M. , Kadyshev V. A. 
Published: November 2024

The constant increase in cases of arterial ischemic stroke requires the development of algorithms for the diagnosis and management of stroke patients. Currently, there are no effective methods for diagnosing arterial ischemic stroke (AII) in children at the stage of emergency medical care (SMP). In 2020, the Prehospital Stroke Diagnosis Scale (DDI) was developed, which may be the optimal algorithm for prehospital diagnosis of childhood stroke.The purpose of the study. To determine the optimal algorithm for prehospital diagnosis of arterial ischemic stroke in children. Objectives of the study: To determine the frequency of occurrence of «masks» of stroke and separately migraine in the structure of cases of hospitalization with suspected ONMC. To evaluate cases of hospitalization with confirmed diagnoses of ischemic stroke and migraine on the DDI Scale. To determine the statistical indicators of the effectiveness of the DDI Scale as the optimal algorithm for prehospital diagnosis of stroke in children.Materials and methods. 401 cases of hospitalization of children to the Center via the NSR channel with symptoms of ONMC for the period from June 2023 to June 2024 were analyzed. All patients were evaluated by the staff of the NSR and the doctors of the Center on the DDI scale. Statistical data on the effectiveness of the DDI Scale are determined.The results of the study. «Masks» of stroke in the structure of cases of hospitalization with suspected ONMC are detected in 94.26 %. Migraine is the main «mask» of AII and is detected in 69 % of cases of stroke «masks» and in 65.05 % of cases among all children with suspected ONMC. High indicators of the effectiveness of the DDI Scale in the differential diagnosis of AII and migraine in children have been established: sensitivity 96 % and specificity 95 %.Conclusion. Thus, the DDI scale can be used as an effective algorithm for diagnosing AII in children, used by NSR staff.
Association between vitamin C intake and thyroid function among U.S. adults: a population-based study
Authors: Wu Jie , Jia Chuyu , Wang Qiang , Li Xin 
Published: November 2024

BackgroundAlthough some evidence suggests a role for vitamin C intake in thyroid diseases, the complex interplay between vitamin C intake and thyroid function remains incompletely understood. The objective of this study was to explore the relationship between vitamin C intake and serum thyroid function in the United States adults.MethodsA total of 5,878 participants from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2012 were included in this study. Weighted multivariate linear regression models, subgroup analyses, and interaction terms were used to assess the association between vitamin C intake, evaluated as a continuous and categorical variable, and thyroid function. Additionally, restricted cubic spline (RCS) regression was employed to assess any nonlinear relationship that may exist between vitamin C intake and thyroid function.ResultsAfter adjusting for covariates, our research found a significant inverse correlation between vitamin C intake and total thyroxine (TT4) (β= -0.182, P= 0.006). Using subgroup analyses, the association was more pronounced among subjects with lower alcohol consumption(β= -0.151, P=0.013, P for interaction = 0.043). In RCS regression, the correlation between vitamin C and TT4 exhibited a distinct reversed L-shaped curve pattern in total participants (P for nonlinear = 0.005) and male adults (P for nonlinear = 0.014). Additionally, we found an inverted U-shaped curve pattern in the relationship between vitamin C intake and FT4 (P for nonlinear = 0.029), while an U-shaped curve relationship was observed between vitamin C consumption and the FT3/FT4 ratio (P for nonlinear = 0.026).ConclusionThe findings of our study have illustrated a notable correlation between vitamin C intake and thyroid function. A high level of vitamin C intake is associated with a decreased in TT4 levels among American adults, and the association was more pronounced among subjects with lower alcohol consumption. Furthermore, our analysis revealed a nonlinear correlation between the intake of vitamin C and the levels of TT4, FT4, and FT3/FT4 ratio. Our findings support the rationale for making food-based dietary recommendations and maybe provide guidance for diet guidelines with thyroid dysfunction to a certain extent in the future.
Chronological outcomes of renal function after adrenalectomy in patients with primary aldosteronism across age groups
Authors: Ma Yu , Tang Xiaofeng , Ge Qian , Xu Jianzhong , Gao Pingjin , Wang Jiguang , Zhu Limin 
Published: November 2024

BackgroundPatients with primary aldosteronism present with renal function decline after unilateral adrenalectomies. Our study aimed to assess the evolution of renal function after adrenalectomy in patients with primary aldosteronism across different age groups and to identify risk factors for postoperative renal function deterioration.MethodsWe included 210 patients with primary aldosteronism categorized into three age groups: &lt;40, 40–60, and ≥60 years old. We followed up the patients for 1 month, 1 year, and 5 years after adrenalectomy to assess outcomes. Multivariate analyses were performed to identify predictors of renal function deterioration, and a univariate logistic regression analysis was used to assess the relationship between KCNJ5 mutation status and the decline in renal function.ResultsPatients aged &lt;40 years had a shorter duration of hypertension, higher preoperative diastolic blood pressure, and higher preoperative estimated glomerular filtration rate (eGFR) than did those in the other age groups. This group also exhibited the highest rate of complete clinical success, although there were no significant differences in complete biochemical success among age groups. Renal function declined in all three groups after adrenalectomy. However, changes in blood pressure and eGFR in the short- or long-term after adrenalectomy showed no significant differences among the three groups. Hypertension duration, preoperative systolic blood pressure (SBP), and plasma aldosterone concentration (PAC) were predictors of postoperative renal function deterioration. KCNJ5 wild-type status was significantly correlated with the occurrence of chronic kidney disease after adrenalectomy.ConclusionsUnilateral adrenalectomy demonstrates favorable biochemical and clinical outcomes in patients with primary aldosteronism, irrespective of age. Long-term eGFR decline is similar among the different age groups. KCNJ5 mutation exhibits a protective effect against the risk of chronic kidney disease after unilateral adrenalectomy.
Phosphorus recovery as vivianite and amorphous calcium phosphate from high-load industrial wastewater
Authors: Randall Dyllon G. , Jalava Justus , Vinnerås Björn , Simha Prithvi 
Published: November 2024

This study evaluated the recovery of amorphous calcium phosphate and vivianite from industrial wastewater produced by a toothpaste manufacturing facility, where phosphorus concentrations exceed 3,000 mg L−1. The goal was to reduce the phosphorus concentration on-site to below 20 mg P L−1, so that treated wastewater can be discharged to a municipal wastewater treatment plant. In bench-scale experiments, various dosages of Ca(OH)2 (10–25 g L−1) and FeSO4·7H2O (20–60 g L−1) were evaluated to identify optimal conditions for precipitating &gt;99% of the phosphorus. Pilot-scale experiments showed that recovery of amorphous calcium phosphate required dosing 25 g L−1 Ca(OH)2 and mixing for 60 min, whereas recovery of metavivianite required co-dosing 60 g L−1 FeSO₄·6–7H₂O and 7.2 g L−1 NaOH and mixing for 15 min. Variations in influent wastewater composition were found to significantly affect the pH as well as concentrations of residual Fe2+ and Ca2+ in the treated wastewater. Impurities present in chemicals used for precipitating phosphorus were found to influence purity of the recovered phosphate products. The chemical demand for recovering 99% of the phosphorus in the toothpaste industry wastewater was found to be significantly higher than for recovering 95% of the phosphorus in conventional municipal wastewater. This was due to a higher treatment goal and the unique composition of the wastewater, characterised by its high ionic strength and elevated concentrations of Na+ and Cl−, which potentially inhibited nucleation and crystal growth during chemical precipitation. A preliminary economic analysis indicated that recovering vivianite, with potential applications in the electronics industry, could generate significantly higher profits compared to amorphous calcium phosphate, but this depends on the product purity. Overall, this study highlights the potential for industrial wastewater to contribute to a circular phosphorus economy.
The role of S100A8 and S100A9 in external auditory canal cholesteatoma
Authors: He Guanwen , Han Weijing , Zhu Zhongshou , Wei Rifu , Lin Chang 
Published: November 2024

BackgroundStudies indicated that diverse cellular mechanisms including epithelial migration and hyper-proliferation, inflammatory responses, and enzymatic bone erosion were involved in the pathogenesis of cholesteatoma. S100A8 and S100A9, which are Ca2+-binding proteins belonging to the S100 family, can trigger the signaling pathways involved in the inflammatory processes, and a variety of cellular processes includes cell cycle progression, proliferation, and cell migration. However, the role of S100A8 and S100A9 and their associated inflammation and other signaling pathways in cholesteatoma have not been investigated yet. This study aimed to investigate the role of S100A8 and S100A9 in external auditory canal cholesteatoma and their potential pathological mechanisms.MethodsThe study conducted histological staining, immunostaining, PCR, and Western blot to investigate the expression of S100A8/A9 and its related pathways in clinic EACC and the murine model of EACC.ResultsOur data showed that there were increased mRNA and protein levels of S100A8 and S100A9 in clinical and animal models of EACC and the S100A8/A9 heterodimer protein was increased in the EACC model. Our study further demonstrated that the increased S100A8 and S100A9 were associated with apoptosis as well as inflammatory (TGF-β, IFN-γ, and IL-10) and angiogenetic (VEGF, HGF/SF, and c-Met) molecular pathways. The correlation analysis indicated that S100A8 and S100A9 were correlated with clinic staging, apoptosis, and inflammatory and angiogenetic factors.ConclusionThis study provided novel insight into the role of S100A8 and S100A9 associated with pathological mechanisms of EACC.
Heterogeneous phenotype of a Chinese Familial WHIM syndrome with CXCR4V340fs gain-of-function mutation
Authors: Huang Yu , Li Lu , Chen Ran , Yu Lang , Zhao Shunkai , Jia Yanjun , Dou Ying , Zhang Zhiyong , An Yunfei , Tang Xuemei , Zhao Xiaodong , Zhou Lina 
Published: November 2024

BackgroundWHIM syndrome is a rare, autosomal dominant inborn error of immunity characterized by warts, hypogammaglobulinemia, infection, and myelokathexis. It is caused mainly by heterozygous mutations at the C-terminus of the C-X-C chemokine receptor type 4 (CXCR4) gene.MethodsWe described the detailed clinical, genetic, immunological and treatment characteristic of four WHIM patients from a single Chinese family.ResultsHere, we report four patients from a family carrying a variant of CXCR4 (c.1016_1017dupCT), which introduces a frameshift at codon V340, resulting in an extension of 14 amino acids (p.V340L fs*27). We provide an in-depth analysis of their clinical, genetic, immunological and treatment characteristic, noting that these patients exhibited an atypical clinical phenotype when compared to reported CXCR4R334X patients. Additionally, the frameshift variant CXCR4V340fs led to impaired receptor downregulation in patients’ PBMCs, and in HEK293T cells transfected with the variant plasmids.ConclusionsOur study provided detailed clinical features of four CXCR4V340fs WHIM patients from one Chinese family who presented atypical phenotype and enrich the spectrum of WHIM syndrome.
Optimizing data-driven arctic marine forecasting: a comparative analysis of MariNet, FourCastNet, and PhyDNet
Authors: Buinyi Aleksei V. , Irishev Dias A. , Nikulin Edvard E. , Evdokimov Aleksandr A. , Ilyushina Polina G. , Sukhikh Natalia A. 
Published: November 2024

IntroductionMarine forecasts play a crucial role in ensuring safe navigation, efficient offshore operations, coastal management, and research, particularly in regions with challenging conditions like the Arctic Ocean. These forecasts necessitate precise predictions of ocean currents, wind-driven waves, and various other oceanic parameters. Although physics-based numerical models are highly accurate, they come with significant computational requirements. Therefore, data-driven approaches, which are less computationally intensive, may present a more effective solution for predicting sea conditions.MethodsThis study introduces a detailed analysis and comparison of three data-driven models: the newly developed convLSTM-based MariNet, FourCastNet, and PhydNet, a physics-informed model designed for video prediction. Through the utilization of metrics such as RMSE, Bias, and Correlation, we illustrate the areas in which our model outperforms well-known prediction models.ResultsOur model demonstrates enhanced accuracy in forecasting ocean dynamics when compared to FourCastNet and PhyDNet. Additionally, our findings reveal that our model demands significantly less training data and computational resources, ultimately resulting in lower carbon emissions.DiscussionThese findings indicate the potential for further exploration of data-driven models as a supplement to physics-based models in operational marine forecasting, as they have the capability to improve prediction accuracy and efficiency, thereby facilitating more responsive and cost-effective forecasting systems.
Association between arteriosclerosis, hemodynamic indices, and the risk of falls: receiver operating characteristic curve analysis for different indices in older individuals
Authors: Zhang Kexin , Ma Yucen , Yang Di , Cao Mengyu , Jin Huijing , Leng Jiyan 
Published: November 2024

ObjectiveThis study aimed to assess the risk factors for falls and evaluate the correlation between arteriosclerosis, hemodynamic indices, and the risk of falls in older individuals.MethodThis cross-sectional study included 920 individuals aged 60 and above from the cadre ward of the First Hospital of Jilin University. Data were obtained from the comprehensive geriatric assessment database of the cadre ward. Ankle-brachial indices (ABI) and brachial-ankle pulse wave velocity (baPWV) were measured using an OMRON arteriosclerosis detection device. Hemodynamic indices were assessed using the CSM3100 thoracic impedance hemodynamic detection system. Fall risk was evaluated with the fall risk assessment tool.ResultsSignificant differences in age, weight, education, smoking status, alcohol consumption, cognitive impairment, malnutrition, daily living abilities, depressive state, baPWV, ABI (all p &lt; 0.001), systolic pressure, heart rate, cardiac stroke volume, and systemic vascular resistance were observed among the three groups (p = 0.011, p = 0.035, p = 0.005, p = 0.016). Ordinal logistic regression analysis indicated that the probability of an increase in fall risk by one level was 2.069 times higher for each unit decrease in educational background. Additionally, fall risk increased by 2.492 times for each additional year of age, 55.813 times for each unit of weight, 3.208 times for smoking status, 3.610 times for alcohol consumption, 4.665 times for cognitive impairment, 2.247 times for malnutrition, 2.596 times for ABI, 2.092 times for heart rate, and 1.586 times for cardiac stroke volume. The receiver operating characteristic curve analysis for fall risk in older individuals demonstrated that ABI was superior to heart rate and systemic vascular resistance in predicting the occurrence of falls.ConclusionOur findings indicate that age, weight, educational background, smoking status, alcohol consumption, cognitive impairment, malnutrition, ABI, systolic blood pressure, heart rate, and cardiac stroke volume are associated with an increased risk of falls in older adults. Moreover, arteriosclerosis and hemodynamic parameters may aid in the early identification of fall risk among older individuals.
Application of the new classification proposal for juvenile idiopathic arthritis of the pediatric rheumatology international trials organization in a group of Mexican patients
Authors: Ramos-Tiñini Pamela , Menchaca-Aguayo Héctor , Alpizar-Rodriguez Deshire , Mercedes-Pérez Esther , Faugier-Fuentes Enrique 
Published: November 2024

ObjectiveApply the PRINTO classification proposal for diagnosing Juvenile Idiopathic Arthritis (JIA) to Mexican patients, analyzing demographic, clinical, and laboratory characteristics.Material and methodsCross-sectional study analyzing patients diagnosed with JIA using International League of Associations for Rheumatology (ILAR 2001) criteria over two years at a national rheumatic disease center. Reclassification was done using the Pediatric Rheumatology International Trials Organization (PRINTO) proposal. Comparisons were made between antinuclear antibodies (ANAs) positive vs. negative and rheumatoid factor (RF) positive vs. negative patients.ResultsSeventy-six patients were analyzed, mostly female. Median age was lower in systemic JIA (sJIA) and early onset JIA with positive ANAs (eoANA JIA). ANAs was present in 78.6% of patients. Reclassification according to PRINTO disorders showed RF positive polyarticular JIA, sJIA, and enthesitis-related JIA (ER JIA) reclassified to RF JIA, sJIA, and enthesitis/spondylitis-related JIA (ESR JIA) by 100%, 94.7%, and 80%, respectively. The ILAR category with the most variation was RF negative polyarticular JIA. Early disease onset was associated with a lower probability of positive RF after adjusting for sex, age, and ANAs. No association was found between ANAs positive vs. negative in adjusted multivariate analysis.ConclusionsWe found compatibility of sJIA, RF positive polyarticular JIA, and RE JIA categories with sJIA, RF JIA, and ESR JIA disorders, respectively. Differences were noted in variables such as sex and the number of affected joints. There was high ANAs positivity; however, few patients were classified into eoANA JIA disorder, with only one presenting uveitis. Most patients were classified as other JIA.