bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of the POTE gene family in human ovarian cancer
Authors: Barger Carter J , Zhang Wa , Sharma Ashok , Chee Linda , James Smitha R. , Kufel Christina N. , Miller Austin , Meza Jane , Drapkin Ronny , Odunsi Kunle , Klinkebiel David , Karpf Adam R. 
Published: November 2018

AbstractThe POTE family includes 14 genes in three phylogenetic groups. We determined POTE mRNA expression in normal tissues, epithelial ovarian and high-grade serous ovarian cancer (EOC, HGSC), and pan-cancer, and determined the relationship of POTE expression to ovarian cancer clinicopathology. Groups 1 & 2 POTEs showed testis-specific expression in normal tissues, consistent with assignment as cancer-testis antigens (CTAs), while Group 3 POTEs were expressed in several normal tissues, indicating they are not CTAs. Pan-POTE and individual POTEs showed significantly elevated expression in EOC and HGSC compared to normal controls. Pan-POTE correlated with increased stage, grade, and the HGSC subtype. Select individual POTEs showed increased expression in recurrent HGSC, and POTEE specifically associated with reduced HGSC OS. Consistent with tumors, EOC cell lines had significantly elevated Pan-POTE compared to OSE and FTE cells. Notably, Group 1 & 2 POTEs (POTEs A/B/B2/C/D), Group 3 POTE-actin genes (POTEs E/F/I/J/KP), and other Group 3 POTEs (POTEs G/H/M) show within-group correlated expression, and pan-cancer analyses of tumors and cell lines confirmed this relationship. Based on their restricted expression in normal tissues and increased expression and association with poor prognosis in ovarian cancer, POTEs are potential oncogenes and therapeutic targets in this malignancy.
Anticancer effects and underlying mechanism of Colchicine on human gastric cancer cell lines in vitro and in vivo
Authors: Zhang Tao , Chen Wei , Jiang Xumian , Liu Lei , Wei Kai , Du Hansong , Wang Hui , Li Juan 
Published: November 2018

Abstract
The present study investigated the effects of Colchicine on gastric carcinoma (GC) cells and explored its possible mechanisms underlying such effects. The results of MTT and colony formation assays showed that Colchicine (2, 5, and 10 ng/ml) markedly inhibited the proliferation of AGS and NCI-N87 cells in a dose-dependent manner. It also led to a reduction in cell migration in both GC cells as determined by Transwell migration assay. Mover, data form Hoechst 33342 staining and flow cytometry assay indicated that Colchicine (2, 5, and 10 ng/ml) promoted the apoptosis of NCI-N87 cells. In addition, the release of cytochrome c, the activation of bax, and the inhibition of bcl-2 were observed in NCI-N87 cells treated with Colchicine. Furthermore, the in vivo experiment further confirmed that Colchicine administration remarkably suppressed the tumor growth in nude mice via induction of apoptosis at 0.05 and 0.1 mg/kg. In addition, no visible toxicity was observed in liver and renal tissue of mice. This finding suggests that Colchicine-induced apoptosis is associated with caspase-3-mediated mitochondrial apoptotic pathways.
ALMA observations of the “fresh” carbon-rich AGB star TX Piscium
Authors: Brunner M. , Mecina M. , Maercker M. , Dorfi E. A. , Kerschbaum F. , Olofsson H. , Rau G. 
Published: November 2018

Aims. The carbon-rich asymptotic giant branch (AGB) star TX Piscium (TX Psc) has been observed multiple times during multiple epochs and at different wavelengths and resolutions, showing a complex molecular CO line profile and a ring-like structure in thermal dust emission. We investigate the molecular counterpart in high resolution, aiming to resolve the ring-like structure and identify its origin.
Methods. Atacama Large Millimeter/submillimeter Array (ALMA) observations have been carried out to map the circumstellar envelope (CSE) of TX Psc in CO(2–1) emission and investigate the counterpart to the ring-like dust structure.
Results. We report the detection of a thin, irregular, and elliptical detached molecular shell around TX Psc, which coincides with the dust emission. This is the first discovery of a non-spherically symmetric detached shell, raising questions about the shaping of detached shells.
Conclusions. We investigate possible shaping mechanisms for elliptical detached shells and find that in the case of TX Psc, stellar rotation of 2 km s−1 can lead to a non-uniform mass-loss rate and velocity distribution from stellar pole to equator, recreating the elliptical CSE. We discuss the possible scenarios for increased stellar momentum, enabling the rotation rates needed to reproduce the ellipticity of our observations, and come to the conclusion that momentum transfer of an orbiting object with the mass of a brown dwarf would be sufficient.
The Tipikor Trial Model Based on IT In implementation of The Hearing on The Islands To Be Fast, Lightweight Cost and Simple
Authors: Sulistyanta  , Adi Santoso Mola Sebastianus , Haba Djingi Fredyk M , Ayu Jati Putri Fatma 
Published: November 2018

Based on Law no. 46 of 2009 on the Court of Corruption, this court has the authority to examine and decide on corruption cases filed by the KPK and the State Prosecutors and High Offices. According to Article 35 paragraph (1) to paragraph (4) of Law no. 46 year 2009 TIPIKOR courts exist only in each provincial capital whose jurisdiction covers the province concerned. The existence of this provision would not want the District Attorney in every district/city should delegate the case to the Corruption Court in the provincial capital. Whereas the area of NTT is an archipelago area where distance between districts with the city of Kupang is very far.
Based on the results research: the cost required by several State Prosecutors’ samples to prosecute 1 (one) case in TIPIKOR Court in Kupang is quite varied, i.e. Rp.127.534.000, -, Rp. 294,096,000, -, Rp. 376,556,000, and Rp. 354,220,000, -. The costs generally have exceeded the cost limit for the determined prosecution of Rp. 190,000,000, -. The variation of cost incurred by each State Prosecutor’s sample gives an illustration that the more distance from Kupang city, the greater the cost. In addition, the duration of the ongoing trial process has had an effect on the cost. Weather factors, flight delays due to bad weather make the trial schedule chaotic, and costs incurred increases. As a result, the work of witnesses becomes neglected, the Public Prosecutor’s job of handling other cases becomes impeded.
Based on the matters above, it is necessary to create a sub-district court model and/or IT-based TIPIKOR judiciary to save relatively expensive cost and cut the time available to bring it closer to the quick, cheap, and simple justice principles. This alternative judicial model of TIPIKOR in addition to contributing to the theoretical level of future development of the judicial system, is expected to become a model for the mining of the judicial system in other islands provinces in Indonesia.
Methodological approaches of mathematics intersubject training with the use of computer mathematical packages in the training system of future bachelors and masters of non-mathematical disciplines under the conditions of informatization
Authors: Gorlov Sergey I. , Kaziakhmedov Toufic B. 
Published: November 2018

Quality of mathematical knowledge in the training system of bachelor’s and master’s of non-mathematical disciplines is a problem of current education. Unfortunately, the newly appeared opportunities of improving the mathematical training quality of the above-mentioned bachelors are not used due to origin of the wealthiest tools of computational and symbolic mathematics. We will think as before: if we have a mathematical thinking, we will get the knowledge. But formation of mathematical thinking of the whole professional community representatives is not only feasible, but also economically profitable, and there is no need for this as well. The use of mathematical methods in various areas of professional activity under the conditions of implementation of information technologies into all spheres of human activity requires revision of teaching methods, content of mathematical training, study of computational methods and mathematical simulation tools.
This article focuses on innovative approaches to mathematical training of bachelors and masters of non-mathematical areas associated with the use of mathematics as a tool for solving professional problems.
The cultural eclecticism of globalism: perspectives from Russia
Authors: Ivanova Oksana , Bilalova Larisa , Knyazeva Ksenia 
Published: November 2018

The paper deals with the reflection of the processes of globalization and multiculturalism in the guise of modern cities. According to the authors of the article, graffiti is a purely urban phenomenon. Modern graffiti is a palette of emotions, feelings, expressive existence, peculiar to the young people, and the modern city is the focus of mad speeds. In this focus of speed collides the seething thirst for life of the youth and the phenomenon of alienation. The dialectic of this contradiction determines the emergence and development of graffiti as a form of self-expression shaped as street art, or as it is sometimes called, the underground art.
Graffiti as a component of street culture expresses the trends of globalization and its subjects, methods, and formats of performance: they are universal and do not have national peculiarities. In this case, the subject line of graffiti is a reflection of the specific features of culture, ideology, history, and traditions, that is, the mentality of a particular society. The authors of the paper present the lack of a single methodological, artistic and ideological orientation as cultural eclecticism. The article represents graffiti as a deviation, however, not as illegal acts but as an orientation of an individual to creative activity, as an act of self-actualization. In the study of graffiti as a socio-cultural phenomenon, parallels are drawn with the art of graffiti in various countries of the world, considering it as a form of multicultural integration. In modern interpretation, graffiti should be viewed as a kind of art, since it is artistic and aesthetic personal reflection of the personality, and creative form of its expression.
Graffiti as an extra-national and meta-social phenomenon is simultaneously a manifestation of universalism of the global socio-cultural tendencies, and an expression of eclecticism of the new forms of the modern city. The main cultural values are outside of time. Traditional values, modified and mutated, are updated in accordance with trends.
Rizaitdin Fakhretdin’s spiritual experience in the development of the ideas of enlightening the peoples of the Volga and the Urals at the turn of the 19th-20th centuries: a historical and philosophical analysis
Authors: Lukyanova Rushalina 
Published: November 2018

This article attempts to analyze the educational views of an outstanding scholar-theologian of 19th-20th century, Rizaitdin Fakhretdin, whose fate and activities reflected the vicissitudes of the complex historical era of the changes in pre-revolutionary Russia and the hard years of the establishment of Soviet power in the regions of the Volga and the Urals.
The spiritual dominant, as a factor of Enlightenment, forms the basis of the evolutionary development of the society. In the conditions of the development of modern Russia and the urgent need to develop the principles of peaceful coexistence of peoples and concessions, the philosophical study of the national and cultural heritage, spiritual experience, the values and traditions of generations, the place and role of ethnonational communities, the destinies of its ideological enlighteners in the spiritual life of modern Russia is of the highest importance. The article also focuses on the development of the spirituality of human being and the degree of enlightenment of the society, which are the foundation of the unity, stability, strength, and greatness of society and the state.
The choice of the topic is dictated by both theoretical interest and practical needs. The contemporaru image of multinational Russia requires a serious historical and philosophical analysis of its social development. The heterogeneous immune nature of the Russian civilization facilitates the assimilation of spiritual and practical experience in the conditions of the coexistence of different peoples. The use of unique socio-historical knowledge stimulates the widening of the capacity of every social, confessional, national community to be involved in the strengthening of Russian unity.
Wirksamkeit von Disease-Management-Programmen für Asthma und COPD? Ergebnisse einer Querschnittstudie
Authors: Kanniess Frank , Krockenberger Katja , Oepen Petra , Hedrich Rahel , Olbrich Denise , Hessler Nicole , Ziegler Andreas , Langer-Brauburger Birgit 
Published: November 2018

Zusammenfassung
Einleitung Die Wirksamkeit der deutschen Disease-Management-Programme (DMP) Asthma und chronisch obstruktive Lungenerkrankung (COPD) kann mit den gesetzlich vorgeschriebenen Dokumentationen nicht gezeigt werden. Studien mit Vergleichsgruppen sind selten. Ziel war es, in einer Querschnittstudie zu untersuchen, ob sich die Krankheitskontrolle bei Teilnehmern (DMP+) und Nicht-Teilnehmern (DMP–) der DMP Asthma und COPD voneinander unterscheidet.
Methoden Die Studie ist eine prospektive, multizentrische Querschnittstudie, die untersucht, inwieweit DMP+-Patienten sich von entsprechenden DMP–-Patienten im Hinblick auf ihre Krankheitskontrolle voneinander unterscheiden. Primärer Endpunkt war die Krankheitskontrolle, gemessen mit dem Asthma-Control-Test™ (ACT) im Studienteil Asthma sowie dem COPD-Assessment-Test™ (CAT) im Studienteil COPD.
Ergebnisse Insgesamt wurden 1038 Asthma-Patienten und 846 COPD-Patienten eingeschlossen, je mit etwa 70 % DMP-Teilnehmern. Der ACT-Score war bei den Asthma-DMP+-Patienten höher als bei den DMP–-Patienten (Mittelwertdifferenz 0,86; 95 %KI: 0,29 – 1,43; p = 0,003), allerdings klinisch nicht relevant. Bei COPD-Patienten fand sich ebenfalls kein klinisch relevanter Unterschied in der Krankheitskontrolle (0,52; 95 %KI: -0,71 – 1,75; p = 0,405). Nur etwa 60 % der Patienten, die seit mindestens einem Jahr in das entsprechende DMP eingeschrieben waren, hatten an einer strukturierten Schulung teilgenommen. Zwischen geschulten und nicht geschulten Patienten fand sich kein Unterschied in der Krankheitskontrolle.
Diskussion Es fand sich kein klinisch relevanter Unterschied in der Krankheitskontrolle zwischen DMP+- und DMP–-Patienten für die DMP Asthma und COPD. International wurde die Wirksamkeit von DMP bei Asthma und COPD in randomisierten Studien nachgewiesen. Auch in Deutschland sollten randomisierte Studien durchgeführt werden, um die Wirksamkeit der DMP Asthma und COPD zu belegen.
Registrierung drks.de, DRKS00007664, Registrierungsdatum: 15.01.2015
Hepatoprotective Activities of Ethanolic Roots Extract of Ageratum Conyzoides on Alloxan-Induced Hepatic Damage in Diabetic Wistar Rats
Authors: Ojewale A.O. , Akpan H.B. , Faduyile F.A. , Shallie P.D. , Akande A.A. , Adefule A.K. 
Published: November 2018

Introduction The aim of the present study was to evaluate the hepatoprotective activities of the ethanolic roots extract of Ageratum conyzoides (AC) in alloxan-induced hepatic damage in diabetic rats.
Materials and Methods Diabetes was induced in Wistar rats by the administration of alloxan (150 mg/kg, intraperitoneal). The ethanolic roots extract of AC, at doses of 250 and 500 mg/kg of body weight, was administered to diabetes-induced rats at a single dose per day for a period of 28 days.
Results The effect of the ethanolic roots extract of AC on blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic oxidative stress markers was measured in the diabetic rats. The ethanolic roots extract of AC exhibited significant reduction of blood glucose (p < 0.05) at the dose of 500 mg/kg when compared with the standard drug glibenclamide (600 µg/kg). The alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels increased significantly (p < 0.05) in the diabetic group without treatment when compared with the control group. In addition, the levels of oxidative stress markers, such as superoxide dismutase (SOD), catalase (CT), glutathione peroxidase (GPx), and glutathione (GSH), were significantly decreased in the diabetic rats compared with the normal rats, while the lipid peroxidation significantly increased in the diabetic group without treatment compared with the control (normal) group. The results demonstrated that the morphological, functional and oxidative stress changes in the liver caused by the ingestion of alloxan were attenuated in diabetic rats treated with the ethanolic roots extract of AC.
Conclusion We concluded that the ethanolic roots extract of AC possesses significant antidiabetic, antioxidant and hepatoprotective effects on alloxan-induced diabetic rats.
Biomechanics Potential of the Masseter and Temporal Muscles in the Mandibles of Mesofacial Subjects
Authors: Pradebon Ana , Pradebon Marieli , Goulart Guilherme , Jotz Geraldo , Malysz Tais , Páfaro Júlia , Reis Magda , de Campos Deivis 
Published: November 2018

Introduction The knowledge of the organization of the masseter muscle (MM) and the temporal muscle (TM) is extremely important when related to the study of the stomatognathic system. Moreover, some authors have shown that mastication is of great importance, not only for the intake of food but also for the systemic, mental and physical functions of the body.
Materials and Methods We have decided to analyze the biomechanical potential (length of the force arm, muscular work and mechanical advantage) of the MM and TM in the mandibles of mesofacial subjects (n = 34).
Results Our results show that the MM exhibits a better biomechanical potential than the TM (p = 0.0001).
Conclusion With these data, orthodontists may develop a specific treatment plan and get better results, especially in cases of patients in whom the biomechanical pattern of the temporomandibular joint is unfavorable.
Comparing apples to apples: an environmental criminology analysis of the effects of heat and rain on violent crimes in Boston
Authors: Sommer Alice J. , Lee Mihye , Bind Marie-Abèle C. 
Published: November 2018

AbstractWeather characteristics have been suggested by many social scientists to influence criminality. According to a recent study, climate change may cause a substantial increase in criminal activities during the twenty-first century. The additional number of crimes due to climate have been estimated by associational models, which are not optimal to quantify causal impacts of weather conditions on criminality. Using the Rubin Causal Model and crime data reported daily between 2012 and 2017, this study examines whether changes in heat index, a proxy for apparent temperature, and rainfall occurrence, influence the number of violent crimes in Boston. On average, more crimes are reported on temperate days compared to extremely cold days, and on dry days compared to rainy days. However, no significant differences in the number of crimes between extremely hot days versus less warm days could be observed. The results suggest that weather forecasts could be integrated into crime prevention programs in Boston. The weather-crime relationship should be taken into account when assessing the economic, sociological, or medical impact of climate change. Researchers and policy makers interested in the effects of environmental exposures or policy interventions on crime should consider a causal inference approach to analyze their data.
Obesity-associated exosomal miRNAs modulate glucose and lipid metabolism in mice
Authors: Castaño Carlos , Kalko Susana , Novials Anna , Párrizas Marcelina 
Published: November 2018

Significance
The presence of extracellular miRNAs in body fluids has been exploited as a brand-new source of biomarkers for different diseases. A fraction of those extracellular miRNAs, contained in extracellular vesicles and exosomes, are additionally being revealed as novel mediators of intercellular communication. Here, we show that systemic injection of exosomes transfected with synthetic miRNAs simulating those enriched in the plasma of obese mice robustly induces glucose intolerance, adipose inflammation, and hepatic steatosis in lean mice. These results support a role for exosomal miRNAs in the modulation of glucose and lipid metabolism in mice and may help us uncover thus far unexplored pathological mechanisms and provide us with novel therapeutic targets.
Parametric amplification of optical phonons
Authors: Cartella A. , Nova T. F. , Fechner M. , Merlin R. , Cavalleri A. 
Published: November 2018

Significance
The amplification of light through stimulated emission or nonlinear optical interactions has had a transformative impact on modern science and technology. The amplification of other bosonic excitations, like phonons in solids, is likely to open up new remarkable physical phenomena. This paper reports an experimental demonstration of optical phonon amplification, supported by first-principle calculations. The combination of our experiments and simulations clarifies a microscopic mechanism for phonon-mediated four-wave mixing, a highly interesting process. Our results could be extended toward an enhanced control of phonon-polariton waves, interesting for information transport on subwavelength length scales.
Indirect reciprocity with private, noisy, and incomplete information
Authors: Hilbe Christian , Schmid Laura , Tkadlec Josef , Chatterjee Krishnendu , Nowak Martin A. 
Published: November 2018

SignificanceIndirect reciprocity explores how humans act when their reputation is at stake, and which social norms they use to assess the actions of others. A crucial question in indirect reciprocity is which social norms can maintain stable cooperation in a society. Past research has highlighted eight such norms, called “leading-eight” strategies. This past research, however, is based on the assumption that all relevant information about other population members is publicly available and that everyone agrees on who is good or bad. Instead, here we explore the reputation dynamics when information is private and noisy. We show that under these conditions, most leading-eight strategies fail to evolve. Those leading-eight strategies that do evolve are unable to sustain full cooperation.
Histone tails decrease N7-methyl-2′-deoxyguanosine depurination and yield DNA–protein cross-links in nucleosome core particles and cells
Authors: Yang Kun , Park Daeyoon , Tretyakova Natalia Y. , Greenberg Marc M. 
Published: November 2018

Significance
DNA modification gives rise to diverse outcomes, including cancer and cell death. Understanding the chemical and biochemical effects of DNA modification contributes to the fundamental understanding of the etiology and treatment of cancer. 2′-Deoxyguanosine methylation at the N7 position (MdG) is a major mechanism of action of some DNA alkylating agents. We examined MdG in nucleosome core particles (NCPs). Abasic site formation from MdG is suppressed in NCPs. Furthermore, MdG and histone proteins form cross-links [DNA–protein cross-links (DPCs)], a deleterious type of DNA damage. DPCs are also formed in cells treated with monofunctional alkylating agent. DPC formation from MdG is a previously unrecognized process that could have significant effects on cells and may play a role in the cytotoxicity of DNA alkylating agents.