bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the Clinical Characteristics and Mortality of Adults Infected with Human Coronaviruses 229E and OC43
Authors: Choi Won-Il , Lee Choong Won 
Published: October 2019

Abstract
Background: There are few studies on the epidemiology and prognosis of coronavirus infections among patients seen in emergency departments and hospital inpatients. The purpose of the study was to compare clinical characteristics and mortality among adults infected with human coronaviruses (HCoV) 229E and OC43.
Methods: We conducted a retrospective cohort study of adults (≥18 years) admitted to the emergency department and ward of a university teaching hospital for suspected viral infection from October 2012 to December 2017. Multiplex real-time polymerase chain reaction (PCR) was used to test for respiratory viruses. Multivariate logistic regression was used to compare mortality among patients with HCoV 229E and HCoV OC43 infections. The main outcome was 30-day all-cause mortality.
Results: Of 8,071 patients tested, 1,689 were found to have a respiratory virus infection. Of these patients, 133 had an HCoV infection, including 12 mixed infections, 44 HCoV 229E infections, and 77 HCoV OC43 infection s. HCoV 229E infections peaked in January and February, while HCoV OC43 infections occurred throughout the year. Sixteen patients (13.2%) with HCoV infections required admission to the intensive care unit. The 30-day all-cause mortality was 22.7% among patients with HCoV 229E infection, and 11.6% among patients with HCoV OC43 infection . Patients infected with HCoV 229E infection had a higher risk of death than those with HCoV OC43 infection (adjusted odds ratio: 2.11, 95% confidence interval: 0.74-6.05).
Conclusions: Infections with HCoVs 229E and OC43 appear to have different seasonal patterns, and HCoV 229E might be more virulent than HCoV OC43.
The statistical importance of a study for a network meta-analysis estimate
Authors: Rücker Gerta , Nikolakopoulou Adriani , Papakonstantinou Theodore , Salanti Georgia , Riley Richard D. , Schwarzer Guido 
Published: October 2019

Abstract
Background: In pairwise meta-analysis, the contribution of each study to the pooled estimate is given by its weight, which is defined based on the inverse variance of the estimate from that study. For network meta-analysis (NMA), the contribution of direct (and indirect) evidence is easily obtained from the diagonal elements of the hat matrix. It is, however, not fully clear how to generalize this to the percentage contribution of each study to a NMA estimate. Methods: After briefly discussing available approaches, we want to question whether it is possible to obtain unique percentage contributions and discuss another approach. We define the importance of each study for a NMA estimate by the reduction of the estimate's variance when adding the given study to the others. An equivalent interpretation is the relative loss in precision when the study is left out. Results: Importances are values between 0 and 1. An importance of 1 means that the study is an essential link of the pathway in the network connecting one of the treatments with the other. These numbers in general do not add to one and thus cannot be interpreted as `percentage contributions'. Conclusions: Importances generalize the concept of weights in pairwise meta-analysis in a natural way. Moreover, they are uniquely defined, easily calculated, and have an intuitive interpretation. We give some real examples for illustration.
Ultrasound-guided quadratus lumborum block for postoperative pain control in patients undergoing unilateral inguinal hernia repair, a comparative study between two approaches.
Authors: Ahmed Abeer , Fawzy Maher , Nasr Mohamed AR. , Hussam Ayman M. , Fouad Eman , Aboeldahb Hesham , Saad Dalia , Osman Safinaz , Fahmy Rania Samir , Farid Mohamed , Waheb Mohsen M. 
Published: October 2019

Abstract
Background : early postoperative ambulation and reduction of hospital stay necessitate efficient postoperative analgesia. Quadrates Lumborum Block (QLB) has been described to provide adequate postoperative analgesia after abdominal surgery. This randomized comparative trial was designed to compare the duration of analgesia provided by two different QLB approaches; the posterior QLB (QLB-2) and transmuscular QLB (QLB-3) in patients undergoing surgical repair of unilateral inguinal hernia.
Methods: Forty patients, aged from 18-50 years, ASA physical status I or II, scheduled for unilateral inguinal hernia repair were enrolled. At the end of the surgical procedure and before recovery from general anesthesia, Patients were randomly assigned into two groups to receive either posterior QLB (Group QLB-2) or transmuscular QLB (Group QLB-3) using 20 ml 0.25% bupivacaine. Duration of analgesia, postoperative VAS and postoperative opioid consumption were recorded.
Results : duration of block was significantly longer in QLB-3 group when compared to QLB-2 group (20.1 + 6.2 hours versus 12.0 + 4.8 respectively) with P value of < 0.001. A statistically significant lower VAS score was recorded in QLB-3 group immediately and 12 hrs postoperative. QLB-3 group showed a statistically significant delayed time of first analgesic request and less postoperative morphine consumption with P value of < 0.001 and 0.001 respectively.
Conclusions : Ultrasound guided postsurgical transmuscular approach of QLB (QLB-3) using 20 ml 0.25% bupivacaine produces more postoperative analgesic effect and less postoperative opioid consumption when compared to posterior QLB approach (QLB-2) in patients underwent unilateral inguinal hernia repair under general anesthesia.
Trial Registration : ClinicalTrials.gov identifier: NCT03526731- on 16 May 2018
Rapid adaptation of signaling networks in the fungal pathogen Magnaporthe oryzae
Authors: Bohnert Stefan , Antelo Luis , Grünewald Christiane , Yemelin Alexander , Andresen Karsten , Jacob Stefan 
Published: October 2019

Abstract
Background One fundamental question in biology is how the evolution of eukaryotic signaling networks has taken place. “Loss of function” (lof) mutants from components of the high osmolarity glycerol (HOG) signaling pathway in the filamentous fungus Magnaporthe oryzae are viable, but impaired in osmoregulation. Results After long-term cultivation upon high osmolarity, stable individuals with reestablished osmoregulation capacity arise independently from each of the mutants with inactivated HOG pathway. This phenomenon is extremely reproducible and occurs only in osmosensitive mutants related to the HOG pathway – not in other osmosensitive Magnaporthe mutants. The major compatible solute produced by these adapted strains to cope with high osmolarity is glycerol, whereas it is arabitol in the wildtype strain. Genome and transcriptome analysis resulted in candidate genes related to glycerol metabolism, perhaps responsible for an epigenetic induced reestablishment of osmoregulation, since these genes do not show structural variations within the coding or promotor sequences. Conclusion This is the first report of a stable adaptation in eukaryotes by producing different metabolites and opens a door for the scientific community since the HOG pathway is worked on intensively in many eukaryotic model organisms.
Career planning differences between male and female deaf students
Authors: Afdal Afdal , Iswari Mega , Alizamar Alizamar , Ifdil Ifdil , Syahputra Yuda , Nurhastuti Nurhastuti 
Published: October 2019

This research aimed to study career planning differences between deaf male and female students. The study consisted of 96 deaf students of West Sumatra high school registered in the semester of January-June 2018, randomly selected by multiple random sampling. Furthermore, the Afdal Career Planning Inventory (ACPI), using the Likert Scale model was used to examine and analyze the study. The results showed no significant difference in the career planning of male and female deaf students. It also showed that the male deaf students are generally in the low category, while the female are in the medium.
Ledipasvir/Sofosbuvir versus Daclatasvir/Sofosbuvir for the Treatment of Chronic Hepatitis C Genotype 4 Patients
Authors: Abdelaty Lamiaa N. , Elnaggar Ahmed A. , Said Amira A. , Hussein Raghda R.S. 
Published: October 2019

Background:
Chronic Hepatitis C (CHC) is a common progressive healthcare challenge
that leads to liver cirrhosis, liver failure, and hepatocellular carcinoma. The optimum therapy was
a combination of pegylated interferon and ribavirin, which was associated with moderate response
and severe side effects. Sofosbuvir revolutionized CHC treatment, especially in combination with
other antiviral agents.

Objective:
The aim of this study was to compare and evaluate the safety and efficacy of sofosbuvir/
daclatasvir versus sofosbuvir/ledipasvir for the treatment of non-cirrhotic naïve patients with
chronic Hepatitis C Virus (HCV) genotype 4 infection for 12 weeks.

Method:
One hundred CHC genotype 4 patients (70 females, 30 males) were recruited from the
hepatology clinic at the Beni-Suef general hospital. Patients were randomly allocated into two
groups that received a 12 weeks treatment of either sofosbuvir 400 mg/daclatasvir 60 mg or sofosbuvir
400 mg/ledipasvir 90 mg. The sustained virological response 12 weeks post-treatment
(SVR12) (HCV RNA < Lower Limit of Quantification (LLOQ)) was determined to evaluate efficacy.
The clinical laboratory tests and any reported adverse effects starting from the administration
of the first dose till 30 days after the last dose were assessed to evaluate safety.
The main outcome measure was the assessment of the safety, efficacy and compliance of sofosbuvir/
daclatasvir versus sofosbuvir/ledipasvir for the treatment of non-cirrhotic naïve CHC genotype
4 patients for 12 weeks.

:
The main outcome measure was the assessment of the safety, efficacy and compliance of sofosbuvir/
daclatasvir versus sofosbuvir/ledipasvir for the treatment of non-cirrhotic naïve CHC genotype
4 patients for 12 weeks.

Results:
SVR12 was achieved by 98% and 96% of patients receiving sofosbuvir plus ledipasvir
and sofosbuvir plus daclatasvir, respectively. The most common adverse events reported were
headache, and fatigue. No patients discontinued treatment due to adverse events.

Conclusion:
The findings from this study suggest that the 12 weeks treatment regimens of sofosbuvir
plus daclatasvir and sofosbuvir plus ledipasvir were both efficacious and well-tolerated in
patients with HCV genotype 4 infection.

Impact on Practice:
In this paper, we report on the most recent approaches in the treatment of
Hepatitis C genotype 4 patients in Egypt. This is significant because this article focuses on comparing
the efficacy and tolerability of the most commonly used antiviral drugs in Egypt.
DUKUNGAN SISTEM INFORMASI MANAJEMEN KEPEGAWAIAN TERHADAP PENGAMBILAN KEPUTUSAN DI BKPP KABUPATEN SUKOHARJO
Authors: Muslikhah Riana Isti 
Published: October 2019

Abstrak: Dukungan Sistem Informasi Manajemen Kepegawaian terhadap Pengambilan Keputusan di BKPP Kabupaten Sukoharjo. Tujuan penelitian ini adalah untuk (1) Mengetahui implementasi Sistem Informasi Manajemen Kepegawaian di BKPP Kabupaten Sukoharjo, (2) Mengetahui dukungan informasi yang dihasilkan oleh Sistem Informasi Manajemen Kepegawaian dalam pengambilan keputusan bidang kepegawaian di BKPP Kabupaten Sukoharjo, (3) Mengetahui kendala dalam implementasi Sistem Informasi Manajemen Kepegawaian di BKPP Kabupaten Sukoharjo. Penelitian ini menggunakan metode penelitian kualitatif. Hasil penelitian menunjukkan bahwa (1) Dalam proses penerapan SIMPEG di BKPP Kabupaten Sukoharjo terdapat sub sistem pengumpulan data, sub sistem input data, sub sistem pengolahan data dan sub sistem output informasi, serta didukung oleh komponen-komponen pendukung yang terdiri dari hardware (perangkat keras), software (perangkat lunak), database, sumber daya jaringan dan brainware (SDM). (2) Informasi yang dihasilkan oleh SIMPEG di BKPP saat ini sudah mampu mendukung dalam pengambilan keputusan penempatan, mutasi dan pensiun pegawai, (3) Kendala yang dihadapi dalam penerapan SIMPEG di BKPP Kabupaten Sukoharjo yaitu: keterbatasan anggaran dan keterlambatan dalam input data. Kata kunci: Sistem, Informasi, Manajemen, Keputusan, Kepegawaian Abstract: Human Resources Management Information System Support for Decision Making in BKPP Sukoharjo Regency. The purposes of this study were (1) to know the Implementation Human Resources Management Information Systems in BKPP of Sukoharjo Regency, (2) know the support information generated by Implementation Human Resources Management Information Systems in BKPP of Sukoharjo Regency in the field of staffing decisions. (3) know the obstacles in the Implementation Human Resources Management Information Systems in BKPP of Sukoharjo Regency. This study used qualitative research methods. The results showed that (1) In the Implementation Human Resources Management Information Systems in BKPP of Sukoharjo Regency there are sub data collection systems, sub system of data input, data processing sub-systems and sub systems output information, and supported by supporting parts consisting of hardware, software, databases, netware and brainware (2) The information generated by Human Resources Management Information Systems at BKPP of Sukoharjo Regency are now able to support decision making in placement, transfer and retirement of employees, but not fully support in the implementation of management staffing in the BKPP of Sukoharjo Regency. (3) The obstacle that is encountered in implementation of the Human Resources Management Information Systems in BKPP of Sukoharjo Regency are : limited budget and delays in data input. Keyword: System, Information, Management, Decision Making, Human Resources
DECENTRALISATIE WET VAN NEDERLAND INDIES 1903
Authors: Hestiliani Teti 
Published: October 2019

AbstractAt the end of the 19th century there was a change in the system of government in the Dutch East Indies, before a central system was implemented in which all activities were regulated by the central government in Batavia. Then this becomes increasingly complex when various affairs in the region must become central business. The change in the system of government in the Indies was then noticed by various figures in the Dutch parliament and government officials in the Dutch East Indies. This change in the system of government was also an effort to improve the standard of living in the Indies which was considered no longer a wingewest area. then in 1901 through his speech Ratu Wilhelmina conveyed that there must be a change in the system of government in the Indies. Then in 1903 a decentralization law was issued as the basis for regional autonomy in the Dutch EastIndies. Keywords: Decentralization, Dutch East Indies, City
Applying an Author-Weighted Scheme to Identify the Most Influential Countries in Research Achievements on Skin Cancer: Observational Study
Authors: Chien Tsair-Wei , Wang Hsien-Yi , Lai Feng-Jie 
Published: October 2019

BackgroundSkin cancers are caused by the development of abnormal cells that can invade or spread to other parts of the body. The countries whose authors contribute the most amount of articles on skin cancer to academia is still unknown.ObjectiveThe objectives of this study are to apply an author-weighted scheme (AWS) to quantify the credits for coauthors on an article byline and allocate the author weights to the country-level credits in articles.MethodsOn July 20, 2019, we obtained 16,804 abstracts published since 1938, based on a keyword search of “skin cancer” in PubMed. The author names, countries/areas, and journals were recorded. International author collaborations on skin cancer were analyzed based on country-level credits in articles. We aimed to do the following: (1) present country distribution for the first authors and the most popular journals, (2) show choropleth maps to highlight the most influential countries, and (3) draw scatter plots based on the Kano model to characterize the features of country-level research achievements. We programmed Excel Visual Basic for Applications (Microsoft Corp) routines to extract data from PubMed. Google Maps was used to display graphical representations.ResultsOur results suggest that researchers in the United States have published most frequently, accounting for 30.37% (5103), while Germany accounts for 7.34% (1234), followed by Australia (997, 5.93%). The top three continents for the proportion of published articles are North America, Europe, and Asia, accounting for 32.29%, 31.71%, and 10.41%, respectively.ConclusionsThis study offers an objective picture of the representativeness and evolution of international research on the topic of skin cancer. The research approaches used here have the potential to be applied to other areas besides skin cancer.
INFLUENCE OF BINDING SOLUTION CONCENTRATION, DRYING DURATION AND DRYING TEMPERATURE ON PHYSIOCHEMICAL PERFORMANCE OF NORFLOXACIN GRANULES AND TABLETS
Authors: OSMAN ZUHAEIR , ADAM NEMAT S. , HASSAN HASSAN A. , O. NUR ABUBAKR 
Published: October 2019

Objective: To investigate the possible individual and joined influences that binding solution concentration, drying temperature and drying duration might have on the physiochemical attributes of granules and tablets using norfloxacin as a model drug.
Methods: According to implemented 23 central composite designs, each of the investigated variables were examined at 5 different levels through different 16 formulation runs. For each formulation, obtained granules were qualified for their bulk density, tap density, Hausner ratio, percent of fine and drug content properties whereas the respective tablets were evaluated for their weight variation, drug content, friability, hardness, disintegration, and drug dissolution attributes.
Results: Indicated that concentration of binder solution, as compared to drying temperature and drying duration, measured more profound influences on granules' tap density, Hausner ratio, % fine and drug content either through its individual linear and quadratic effects or through its joint effect with drying durations (p<0.05 at 95% CI for all influences). Whilst tablets' friability appeared to be noticeably influenced by the three investigated variables (P ranged 0.001-0.017 at 95% CI), tablets' hardness and disintegration were found to be considerably affected only by binder solution concentration (p = 0.001 and 0.082 at 95% CI, respectively). Moreover, none of the investigated variables has measured a significant influence on tablets' drug content or drug dissolution properties.
Conclusion: The study concluded that quadratic and joint influences of variables on attributes of granule and tablet formulations shouldn't be overlooked and better to be considered in the screening design.
Os cenários como elemento narrativo em Steven Universo
Authors: Abrahão de los Santos Eduarda , De Moraes Bueno Bernardo José , Tartarotti Postay Andrezza 
Published: October 2019

Steven Universo (2013-2019) é uma animação criada por Rebecca Sugar para o canal Cartoon Network, com mais de 150 episódios de dez minutos cada. O time de produção da série diz que há cuidado para que os cenários mostrem, com suas cores, linhas (e ausência delas), iluminação e composição, lugares vivos que o espectador entenda como mais do que apenas um pano de fundo para a ação. Neste trabalho, discutiremos o contraste entre as ambientações de dois episódios - Libertador e A resposta - nos quais aparecem cenários associados ao Planeta Natal e à Terra, enquanto seguimos momentos decisivos da união amorosa das personagens Rubi e Safira. Fazendo uso da Narratologia (Bal), assim como de estudos de quadrinhos (McCloud) e de teorias de cores e design (Lupton e Phillips), pretende-se demonstrar a maneira como os cenários integram a narrativa, já que a ambientação muda completamente dependendo do estado emocional das personagens e sua percepção sobre o local onde se encontram. Além disso, as próprias personagens agem sobre o cenário, modificando-o e mantendo, assim, a coesão visual das associações feitas a elas, a sua relação, e ao planeta Terra.
UJI KEPRAKTISAN LEMBAR KERJA SISWA YANG MENGGUNAKAN PENDEKATAN SAINTIFIK
Authors: Megananda Ayu Sayu Mas , Wiratma I Gusti Lanang , Sastrawidana I Dewa Ketut 
Published: October 2019

Abstrak Penelitian ini bertujuan untuk mendeskripsikan dan menjelaskan kepraktisan LKS pada pembelajaran kimia pokok bahasan larutan elektrolit dan nonelektrolit yang menggunakan pendekatan saintifik. Penelitian ini merupakan penelitian pengembangan yang dilakukan dengan beberapa tahap, yaitu: (1) pengumpulan data; (2) desain produk; (3) validasi desain; (4) revisi desain (5) uji coba produk; dan (6) revisi produk. Validitas LKS melibatkat dua ahli isi, satu ahli bahasa, dan dua praktisi. Uji coba produk dilakukan dengan uji coba lapangan terbatas yang melibatkan sembilan siswa kelas XI SMAN 1 Kuta Selatan. Hasil uji kepraktisan diperoleh bahwa siswa memberikan respon positif terhadap LKS menggunakan pendekatan saintifik Kata kunci: lembar kerja siswa, pendekatan saintifik, larutan elektrolit dan nonelektrolit. Abstract This study was conducted aimed at describing and explaining the practicality of LKS in learning the subject chemistry of electrolyte and non-electrolyte solutions that use a scientific approach. This research is a development research carried out in several stages, namely: (1) data collection; (2) product design; (3) design validation; (4) design revisions (5) product trials; and (6) product revisions. The validity of the LKS involved two content experts, one linguist, and two practitioners. The product trial was conducted with a limited field trial involving nine students of class XI SMAN 1 Kuta Selatan. The practicality test results obtained that students gave a positive response to the LKS using a scientific approach Keywords: student worksheets, scientific approach, electrolyte solutions and nonelectrolytes.
Faktor Determinan Minat Wirausaha Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Negeri Gorontalo
Authors: Mopangga Herwin 
Published: October 2019

This research aims to describe the actual condition of the entrepreneurial student at the Faculty of Economics and Business, Gorontalo State University (FEB-UNG), identifying the determinant factor of student entrepreneurial intention and to formulate alternative ways to improve the entrepreneurial intention. Use qualitative descriptive method, primary data obtained by 50 selected respondent, and secondary data from student division of FEB-UNG office. Research concludes, first, it is generally, student entrepreneurial intention still relatively low, evidenced by the lack of FEB students become entrepreneur, low involvement in training/workshop and seminar about entrepreneurship inside or outside of campus as well as the lack of number of business plan that competed in Program of Student Creativity (PKM). Second, relatively low of entreprenurial intention is highly determined by the lack supporting of parents and family who works as civil servant or private employees, public perception and also entrepreneurial learning atmosphere and facilities that have to be acces inside of campus. Third, the solutions offered is multiplied the frequence of entrepreneurial practices, carried out of learning contextual periodically, provide the entrepreneurial facilities, business incubator program, business plan writing contest, budget allocation and entrepreneurial network integrated with local stakeholder.