bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for post-colorectal endoscopic submucosal dissection (ESD) coagulation syndrome: a multicenter, prospective, observational study
Authors: Arimoto Jun , Higurashi Takuma , Kato Shingo , Fuyuki Akiko , Ohkubo Hidenori , Nonaka Takashi , Yamaguchi Yoshikazu , Ashikari Keiichi , Chiba Hideyuki , Goto Shungo , Taguri Masataka , Sakaguchi Takashi , Atsukawa Kazuhiro , Nakajima Atsushi 
Published: March 2018

Abstract
Background and study aims Colorectal cancer (CRC) is one of the most common neoplasms and endoscopic submucosal dissection (ESD) is an effective treatment for early-stage CRC. However, it has been observed that patients undergoing ESD often complain of pain, even if ESD has been successfully performed. Risk factors for such pain still remain unknown. The aim of this study was to explore the risk factors for post-colorectal ESD coagulation syndrome (PECS).
Patients and methods This was a prospective multicenter observational trial (UMIN000016781) conducted in 106 of 223 patients who underwent ESD between March 2015 and April 2016. We investigated age, sex, tumor location, ESD operation time, lesion size, duration of hospitalization, and frequency of PECS. We defined PECS as local abdominal pain (evaluated on a visual analogue scale) in the region corresponding to the site of the ESD that occurred within 4 days of the procedure.
Results PECS occurred in 15/106 (14.2 %), and 10 were women (P = 0.01, OR: 7.74 [1.6 – 36.4]), 7 had lesions in the cecum (P < 0.001, OR: 20.6 [3.7 – 115.2]), and 9 in whom ESD operation time was > 90 min (P = 0.002, OR: 10.3 [2.4 – 44.6]). Frequency of deviation from the prescribed clinical path was significantly higher (47 % [7/15] vs. 2 % [2/91], P < 0.001, OR: 38.9 [6.9 – 219.6]), and hospital stay was significantly longer in the PECS group.
Conclusions Female gender, location of lesion in the cecum, and ESD operation time > 90 minutes were significant risk factors independent of PECS. These findings are important to management of PECS.
Aggregations and associations in deep-sea chondrichthyans
Authors: Finucci Brittany , Dunn Matt R , Jones Emma G ,   Handling editor: Valerio Bartolino
Published: March 2018

AbstractGroup living has been recorded across a diverse range of chondrichthyans, but due to a variety of factors, any inferences of social associations in deep-sea cartilaginous fishes have yet to be described. Using a companion preference analysis, aggregating behaviour and associations in deep-sea chondrichthyans (four holocephalans, ten elasmobranchs) were evaluated across class and group size from long-term archived fisheries independent research trawl survey datasets. Results indicated that not all selected species engaged in aggregative behaviour, but those that did suggested patterns of sex- and size-specific associations, which varied with catch density. Adult females were caught most frequently in low densities, and were highly associated with other adult females. Adult males were consistently associated with each other. The nature of associations has important implications for selective mortality by spatial or temporally stratified, or aggregation-targeting, fisheries.
P2X Receptors
Authors: Nicke Annette , Grutter Thomas , Egan Terrance M. 
Published: March 2018

Abstract
P2X receptors are ATP-gated ion channels that are ubiquitously expressed in eukaryotic tissues. They are involved in diverse physiological processes, from modulation of synaptic transmission, to inflammation, sensing of taste, bladder filling, and pain. Research on these receptors was for a long time hampered by a complex pharmacology and lack of high-resolution structures. However, the use of novel and modern methods brought significant progress and insight into receptor function. This article reviews P2X receptor structure, molecular function, and cellular physiology, emphasizing recent studies using crystallography, optical tools, and gene ablation to describe the sequence of events leading from agonist binding to physiological response. These studies reveal remarkable structural and functional properties not found in other ligand-gated ion channels, but still relevant to the field as a whole.
Evidentiality in Mongolic
Authors: Brosig Benjamin , Skribnik Elena 
Published: March 2018

AbstractMiddle Mongol, first attested in the thirteenth century, exhibits three evidential markers that were restricted to the past tense: evidentially neutral -bA, direct -lUGA, and indirect -JUGU. Its modern successors show different systems which mostly pattern areally. The two most complex systems developed in Kalmyk (west) and Khalkha (central), where evidentiality spread to other tenses and is also expressed through semantically more specific analytic constructions. In several Southern and Central Mongolic varieties of Amdo (southwest), binary systems evolved under Amdo Tibetan influence; these distinguish between participatory and non-participatory evidence. Buryat, Khorchin, and Dagur (northeast) as well as Southern Mongolic varieties of Gansu (south) lack paradigmatic evidentiality, losing or reinterpreting the inherited evidential suffixes. Some evidential strategies evolved that cut across the Mongolic area, including structurally identical prospectives (Khalkha, Buryat, Khorchin) or the extension of ‘say’ to denote hearsay (Central and Southern Mongolic).
Evidentiality in Tibetic
Authors: DeLancey Scott 
Published: March 2018

AbstractThis chapter describes the evidential and related catetgories of Tibetic languages, concentrating on the Lhasa variety. Tibetic languages show an unusual evidential system based on a three-way grammatical distinction among Factual or assumed knowledge, Egophoric or personal knowledge, and Evidential or contingent facts. Evidentiality per se, specifically the distinction between directly and indirectly acquired knowledge, is distinguished only for propositions of the third type. Some Tibetic languages such as Lhasa and Standard Tibetan further subdivide the Egophoric category and distinguish volitional and non-volitional Egophoric forms. All of these categories are matters of presentation, not objective fact; that is, a particular grammatical construction is chosen not in automatic response to an objective situation, but in order to convey a proposition to the addressee in a particular perspective.
Evidentiality and Its Relations With Other Verbal Categories
Authors: Forker Diana 
Published: March 2018

AbstractThis chapter focuses on languages that mark evidentiality within the verbal complex. It provides an overview of the interrelations between evidentiality and other categories expressed on verbs. The categories investigated are tense, aspect, modality, polarity, person agreement, mood/speech act type, finiteness, Aktionsart/semantically defined verb classes, and mirativity. Languages worldwide exhibit many peculiarities both with respect to the semantic as well as the formal relations between these categories and evidentiality. Furthermore, the relationships are multivaried and often include more than two categories, which leads to even more intricate interactions. Therefore, it is often impossible to arrive at cross-linguistically valid generalizations, especially with respect to the categories aspect, finiteness, and also tense.
The Reportative in the Languagesc of the Philippines
Authors: Daguman Josephine S. 
Published: March 2018

AbstractThis chapter presents the results of research on the reportative in over two dozen Austronesian languages spoken in different parts of the Philippines. It shows a sampling of forms that the reportative takes and discusses its grammar, semantics, pragmatics, discourse functions, and derivations. The last of these is found only in a few languages that allow the process. It also touches on a distinct reportative of the newscasting register. The latter part of the chapter tackles how social changes have hastened diffusion of reportative forms in areas beyond the homeland of their original users. The chapter ends with a summary of the findings.
Households and Communities
Authors: Webley Leo 
Published: March 2018

Abstract
The household is often seen as the basic unit of European Iron Age societies, but the role of the domestic sphere as a social arena has received relatively little attention. This chapter compares the nature and internal organization of household groups in selected Iron Age societies, examining not just the architectural layouts of houses and farmsteads, but also the residues of everyday practice. The dynamic nature of the relationship between household groups and the built spaces they inhabited is emphasized. Relations between households, and how they were integrated into wider communities, are also considered. In some societies, individual households were dispersed across the landscape, whereas in others they were clustered in large, nucleated ‘villages’. In many Iron Age societies, the local community—rather than larger ‘tribal’ groupings—was the primary level at which meaningful authority was articulated and negotiated.
Karaoke, Queer Theory, Queer Performance
Authors: Tongson Karen 
Published: March 2018

Abstract
This article explores the relationship between karaoke aesthetics—focused on the copy and re-enactment—and approaches to imitation and mimesis in queer, as well as post-colonial aesthetics. By revisiting histories of the purported invention of the first karaoke machines in the Asia Pacific region, this essay forges connections between the styles of performance engendered by karaoke apparatuses and LGBTQ amateur recreations such as drag, and karaoke’s precursor, the piano bar. Furthermore, viewing queer aesthetics through the lens of karaoke aesthetics makes apparent the very specialized regimes of knowledge in both, which are often regarded as improvisationally based, but are actually contingent upon a particular set of decorums, historically contingent repertoires, and meticulous methods of recreation and practice. Finally, the essay accounts for how constitutive the concept of “repetition” is not only for karaoke, but also queer scholarship focused on performance studies, as well as belle-lettristic literary traditions.
Feasibility Study of Human Corneal Endothelial Cell Transplantation Using an In Vitro Human Corneal Model
Authors: Rolev Kostadin , O'Donovan Dominic G. , Coussons Peter , King Linda , Rajan Madhavan S. 
Published: March 2018

Purpose:
To test the feasibility of a cell therapy approach to treat corneal endothelial (CE) disorders using an in vitro model of human corneal decompensation.

Methods:
A CE decompensation model was established by removal of the Descemet membrane/endothelium complex from cadaveric human corneas in an air interface organ culture system (group 2) and compared with normal corneas (group 1). The posterior stroma of decompensated corneas was seeded with immortalized human corneal endothelial cells (HCEC-12) in group 3 and passage 0 primary human CE cells in group 4 corneas. Functional effects on stromal thickness were determined with histological analysis 3 to 10 days after cell therapy treatment.

Results:
Removal of the Descemet membrane/endothelium complex in group 2 corneas resulted in a stromal thickness of 903 ± 86 μm at 12 hours compared with 557 ± 72 μm in group 1 corneas. Stromal thickness reduced from 1218 ± 153 μm to 458 ± 90 μm (63% ± 6%, P = 0.001) after cell transplantation in group 3 and from 1100 ± 86 μm to 489 ± 94 μm (55% ± 7%, P = 0.00004) in group 4. Posttransplantation histology demonstrated formation of a monolayer of corneal endothelium attached to the posterior stromal surface.

Conclusions:
Direct transplantation of cultured human CE cells and immortalized HCEC-12 to bare posterior corneal stroma resulted in formation of an endothelial monolayer and restoration of stromal hydration to physiological thickness, demonstrating the feasibility of cell therapy in treatment of CE decompensation in a human in vitro model.
Jackhammer Esophagus
Authors: Sloan Joshua A. , Mulki Ramzi , Sandhu Naemat , Samuel Solomon , Katz Philip O. 
Published: March 2018

Goals:
The aim of our study was to characterize jackhammer esophagus symptoms and their relationship with the distal contractile integral (DCI) and bolus transit.

Background:
Jackhammer esophagus is defined by the Chicago Classification version 3.0. This diagnosis is relatively new, with the most current definition being established in 2014. The forerunners of this diagnosis, nutcracker (or hypercontractile) esophagus, have been associated with noncardiac chest pain (NCCP).

Study:
A retrospective chart review was performed of motility studies from 2011 to 2016. Studies with a diagnosis of jackhammer esophagus, hypercontractile esophagus, nutcracker, esophagogastric junction outflow obstruction, or hypertensive lower esophageal sphincter were reread using Chicago Classification version 3.0, and were included if they met criteria for jackhammer esophagus. Unpaired t-tests were used for analysis (P≤0.05).

Results:
In total, 142 studies were identified with the above diagnoses. After excluding 84 studies, 58 remained for analysis and 17 were found to have jackhammer esophagus (29%). The mean age was 54 (28 to 75), 5 (29%) were males and 12 (71%) were females. The primary indications were NCCP (5), dysphagia (8), and other causes (4) (cough, heartburn, or regurgitation). The mean DCIs were 17,245 mm Hg×s×cm (NCCP), 14,669 mm Hg×s×cm (dysphagia), and 11,264 mm Hg×s×cm (other causes). The mean DCIs were compared: NCCP versus dysphagia (P=0.41), and NCCP versus other causes (P=0.05). Fifteen (88%) had normal bolus transit for both liquid and viscous swallows.

Conclusions:
In our small sample size, dysphagia was frequently the presenting symptom followed by NCCP. Those with NCCP have a trend toward a higher DCI. Bolus transit appeared to be normal in this patient population. More data are needed to further elucidate the genesis of symptoms and how they relate to the degree of contractility.
Impending Atypical Femoral Fracture in a Patient of Breast Cancer With Bone Metastases Receiving Long-term Denosumab
Authors: Sugihara Tsutomu , Koizumi Mitsuru , Hayakawa Keiko , Ito Yoshinori , Sata Naohiro 
Published: March 2018

Abstract
Atypical femoral fractures (AFFs) occur in both osteoporosis patients and cancer patients who receive long-term bisphosphonate treatment. Denosumab offers an alternative approach for the treatment of bone metastases. We describe a 59-year-old woman with a history of breast carcinoma and bone metastasis who was prescribed denosumab for 4 years. The patient had no history of any prior bisphosphonate use. Bone scintigraphy showed an abnormal uptake in the right femur, which was confirmed as an impending AFF or atypical femoral stress reaction. In oncological patients receiving long-term denosumab, AFF should be included as a differential diagnosis for focal femoral findings.
MetaWRAP - a flexible pipeline for genome-resolved metagenomic data analysis
Authors: Uritskiy Gherman V , DiRuggiero Jocelyne , Taylor James 
Published: March 2018

AbstractBackground:The study of microbiomes using whole-metagenome shotgun sequencing enables the analysis of uncultivated microbial populations that may have important roles in their environments. Extracting individual draft genomes (bins) facilitates metagenomic analysis at the single genome level. Software and pipelines for such analysis have become diverse and sophisticated, resulting in a significant burden for biologists to access and use them. Furthermore, while bin extraction algorithms are rapidly improving, there is still a lack of tools for their evaluation and visualization.Results:To address these challenges, we present metaWRAP, a modular pipeline software for shotgun metagenomic data analysis. MetaWRAP deploys state-of-the-art software to handle metagenomic data processing starting from raw sequencing reads and ending in metagenomic bins and their analysis. MetaWRAP is flexible enough to give investigators control over the analysis, while still being easy-to-install and easy-to-use. It includes hybrid algorithms that leverage the strengths of a variety of software to extract and refine high-quality bins from metagenomic data through bin consolidation and reassembly. MetaWRAP’s hybrid bin extraction algorithm outperforms individual binning approaches and other bin consolidation programs in both synthetic and real datasets. Finally, metaWRAP comes with numerous modules for the analysis of metagenomic bins, including taxonomy assignment, abundance estimation, functional annotation, and visualization.Conclusions:MetaWRAP is an easy-to-use modular pipeline that automates the core tasks in metagenomic analysis, while contributing significant improvements to the extraction and interpretation of high-quality metagenomic bins. The bin refinement and reassembly modules of metaWRAP consistently outperform other binning approaches. Each module of metaWRAP is also a standalone component, making it a flexible and versatile tool for tackling metagenomic shotgun sequencing data. MetaWRAP is open-source software available at https://github.com/bxlab/metaWRAP.
ExTraMapper: Exon- and Transcript-level mappings for orthologous gene pairs
Authors: Ay Ferhat , Chakraborty Abhijit , Davuluri Ramana V. 
Published: March 2018

ABSTRACTAccess to large-scale genomics and transcriptomics data from various tissues and cell lines allowed the discovery of wide-spread alternative splicing events and alternative promoter usage in mammalians. However, evolutionary studies primarily focus on gene-level orthology relationships, which hinders the importance of transcript-level diversity. Between human and mouse, gene-level orthology is currently present for nearly 16k protein-coding genes spanning a diverse repertoire of over 200k total transcript isoforms. Here we describe a novel method, ExTraMapper, which leverages sequence conservation between exons of a pair of organisms and identifies a fine-scale orthology mapping at the exon and then transcript level. ExTraMapper identifies more than 250k exon, as well as 30k transcript mappings between human and mouse using only sequence and gene annotation information. We demonstrate that ExTraMapper identifies a larger number of exon and transcript mappings compared to previous methods. Further, it identifies exon fusions, splits, and losses due to splice site mutations, and finds mappings between microexons that are previously missed. By reanalysis of RNA-seq data from 13 matched human and mouse tissues, we show that ExTraMapper improves the correlation of transcript-specific expression levels suggesting a more accurate mapping of human and mouse transcripts. ExTraMapper also reports better transcript-level mappings compared to Ensembl orthology for the human proto-oncogene BRAF and its mouse ortholog as well as several other example genes with important isoform-specific functions. ExTraMapper is applicable to any pair of organisms that have orthologous gene pairs and is available at https://github.com/ay-lab/ExTraMapper and http://ay-lab-tools.lji.org/extramapper
Functional Asymmetries between Central and Peripheral Retinal Ganglion Cells in a Diurnal Rodent
Authors: Escobar María-José , Otero Mónica , Reyes César , Herzog Rubén , Araya Joaquin , Ibaceta Cristóbal , Palacios Adrián G. 
Published: March 2018

AbstractThe segregated properties of the visual system processing central or peripheral regions of the visual field have been widely studied in the visual cortex and the LGN, but rarely reported in retina. The retina performs complex computational strategies to extract spatial-temporal features that are in coherence with animal behavior and survival. Even if a big effort has been done to functionally characterize different retinal ganglion cell (RGC) types, a clear account of the particular functionality of central and peripheral cells is still missing. Here, using electrophysiological data obtained with a 256-MEA recording system on female diurnal rodent retinas (Octodon degus), we evidenced that peripheral RGCs have larger receptive fields, more sustained, faster and shorter temporal responses and sensitive to higher temporal frequencies with a broader frequency bandwidth than the center. Additionally, we also compared the asymmetries between ON and OFF cell populations present in each region, reporting that these asymmetries are dependent on the eccentricity. Finally, the presence of the asymmetries here reported emphasizes even more the complexity of computational strategies performed by the retina, which could serve as inspiration for the development of artificial visual systems.
eWOM through social networking sites and impact on purchase intention and brand image in Iran
Authors: Farzin Milad , Fattahi Majid 
Published: March 2018

PurposeThe purpose of this paper is to build a conceptual framework which provides both practical and theoretical insights into drivers of consumer use of social network sites (SNSs) as an electronic word-of-mouth (eWOM) tool and its impact on brand image (BI) and purchase intention (PI).Design/methodology/approachFor assessment of the research constructs, the measures proposed in the social psychology and marketing literature were adapted. These scales were examined for the face validity by the authors’ academic colleagues. Using the survey data collected from the students of the Islamic Azad University, these scales were further examined in terms of convergent and discriminant validity as well as reliability. Structural equation modelling technique was used to test the effect of eWOM antecedents on consumer eWOM intention and the eWOM impact on BI and consumer PI.FindingsThe results confirmed significance of the constructs consumer trust, informational influence, sense of belonging, altruism, moral obligation, and knowledge self-efficacy for consumer engagement in eWOM. The results further indicated that eWOM, in turn, played a significant role in shaping BI in the mind of consumers and their PI.Research limitations/implicationsObviously, university students do not exactly represent the whole population of SNSs members. The eWOM intention can be investigated across generations in terms of intergenerational differences. The authors admit that in addition to the constructs used in this study there are other equally important constructs that can be adapted from relevant fields (e.g. psychology) as the eWOM antecedents. As for eWOM consequences, different aspects of brand equity could be additionally explored and investigated.Practical implicationsThe results of this study would help marketing department of companies and advertising agencies make advertisements in accordance with consumer characteristics. The results would also benefit providers of online platforms by giving them insight into behaviour of their members. Finally, the finding that eWOM intention is likely to create PI among consumers is of particular interest to producers of goods.Originality/valueGiven its bidimensional perspective to eWOM behaviour (i.e. considering both antecedents and consequences of eWOM), this study provides valuable insights into the phenomenon eWOM in the context of social networks as well as a basis for further research in this field.