bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein‐Variant‐Phenotype Study of NBAS Using AlphaFold in the Aspect of SOPH Syndrome
Authors: Zhozhikov Leonid , Vasilev Filipp , Maksimova Nadezhda 
Published: December 2024

ABSTRACTNBAS gene variants cause phenotypically distinct and nonoverlapping conditions, SOPH syndrome and ILFS2. NBAS is a so‐called “moonlighting” protein responsible for retrograde membrane trafficking and nonsense‐mediated decay. However, its three‐dimensional model and the nature of its possible interactions with other proteins have remained elusive. Here, we used AlphaFold to predict protein–protein interaction (PPI) sites and mapped them to NBAS pathogenic variants. We repeated in silico milestone studies of the NBAS protein to explain the multisystem phenotype of its variants, with particular emphasis on the SOPH variant (p.R1914H). We revealed the putative binding sites for the main interaction partners of NBAS and assessed the implications of these binding sites for the subdomain architecture of the NBAS protein. Using AlphaFold, we disclosed the far‐reaching impact of NBAS variants on the development of each phenotypic trait in patients with NBAS‐related pathologies.
Enhancing Sustainable Development Through Interdisciplinary Collaboration: Insights From Diverse Fields
Authors: Vaverková Magdalena Daria , Polak Joanna , Kurcjusz Małgorzata , Jena Manoj Kumar , Murali Aparna P. , Nair Surya Sasikumar , Aktaş Havva , Hadinata Muhammad Effsal , Ghezelayagh Pouya , Andik Silvia Dewi Sagita , Rahmana Adhitya , Franc‐Dąbrowska Justyna 
Published: December 2024

ABSTRACTAchieving sustainable development (SD) requires a holistic approach that bridges multiple disciplines. Although the current literature recognizes the critical role of interdisciplinary collaboration in comprehensively addressing global challenges across fields such as economics, business, environmental science, and social justice, there is still a significant gap in understanding how specific contributions from each discipline can be effectively combined to strengthen the implementation of the Sustainable Development Goals (SDGs). In this paper, we examine the interconnected nature of the SDGs and the critical role of interdisciplinary collaboration in achieving them. Addressing complex challenges such as poverty, inequality, climate change, and environmental degradation requires contributions from diverse fields, including biology, ecology, toxicology, chemistry, physics, mechanics, environmental engineering, architecture, and urban planning. The purpose of this paper is twofold (i) to explore the interconnected nature of the SDGs and the need for interdisciplinary collaboration to achieve them, and (ii) to highlight how contributions from different disciplines can enhance our ability to address the complex challenges associated with SD. We emphasize the integration of sustainable principles and innovative approaches as essential to fostering collaboration. Our findings suggest that inclusive, interdisciplinary strategies are critical for SD and underscore the urgent need for collective action across sectors to achieve the SDGs, strengthen global resilience, and drive innovation in SD. Adopting interdisciplinary efforts creates pathways for innovative, inclusive, and sustainable impacts that support a healthier planet and a resilient future for all.
A Comparative Analysis of the Indian Lunacy Act 1912 and Pakistan's Mental Health Ordinance 2001
Authors: Younas Arooba , Qureshi Abeeda 
Published: December 2024

ABSTRACTThis study compares the Indian Lunacy Act (ILA) 1912 with the Mental Health Ordinance (MHO) 2001 to demonstrate the (dis)continuity of colonial practices in the context of postcolonial Pakistan. This analysis is informed by Foucauldian power/knowledge nexus making a unique contribution to the broader field of mental health policy. The discursive continuity of the colonial legacy involving the legal structures in the mental health system, where the state uses psychiatric knowledge to legitimize the detention of individuals, echoes the Foucauldian concept of the power/knowledge nexus. Scrutinizing the words used in both legislations, it has been understood that language is not neutral; rather it is suffused with meaning, creating knowledge and truths. This is seen through the offensive words used in the ILA 1912 that denote degradation, disdain, and contempt toward the “insane,” “dangerous,” and “lunatics.” Although MHO 2001 adopted a more neutral language, a continuation of the mechanism of control is seen during the admitting process, in which the opinions and statements of medical professionals play an important role. The marginalization of alternative mental health practices, in the form of indigenous and communal mental health practices in both mental health legislations, showcases the dominance of the biomedical model, enforcing a particular form of epistemic control. Nonetheless, the relative improvement of the MHO 2001, as opposed to the ILA 1912, has been seen in terms of the language used and the inclusion of community‐based mental health services.
Psychological and Brain Development
Authors: Schleim Stephan 
Published: December 2024

AbstractAge limits play an important role in various areas of law. In this chapter, we look at the psychological, biological and neuroscientific research on puberty, adolescence and adulthood. According to new proposals, adolescence extends from the age of ten to 24. While various studies suggest that cognitive development has reached adult level by the age of 16–20, researchers assume a longer process for emotional and social maturity. These views are compared with new findings on brain development. The question of the extent to which “typical” adolescent behavior is a reaction to psychosocial circumstances is also addressed. A specific “adolescent brain” cannot be identified based on current knowledge.
A Generalisation of Emerson’s recurrence formulae and the Gray-Williams index
Authors: Beh Eric J. , Lombardo Rosaria 
Published: December 2024

AbstractWhen analysing the association between the ordered categorical variables of a contingency table, orthogonal polynomials derived from the recurrence formulae of Emerson (1968, Biometrics, 24: 695 - 701) have been extensively used. The calculation of such polynomials is somewhat limited because they reflect only the univariate structure of each variable. This paper proposes a new generalisation of Emerson’s recurrence formulae that reflects bivariate and, more generally, multivariate, association structures for the construction of orthogonal polynomials for multi-way contingency tables. We shall demonstrate the utility of this generalisation by giving special attention to the Gray-Williams index, a three-way variant of the Goodman-Kruskal tau index.
The last generation: F3 of Echinometra sea urchins under experimental climate change
Authors: Uthicke Sven , Patel Frances , Thoben Femke , Dee Alice , Lamare Miles 
Published: December 2024

AbstractOcean warming and acidification are a threat to calcifying marine invertebrates such as Echinoderms. Transgenerational plasticity may allow animals to respond to these conditions, but few studies exposing marine invertebrates to climate stressors over multiple generations exist. Here, data from the final (F2 post-settlement, F3 larvae and juveniles) generations in a long-term (> 6 yrs) experiment on the tropical sea urchin Echinometra sp. A. This commenced with exposing wild collected animals (F0 generation) and subsequent generations (larvae and adults both for F1 and F2) to control (present-day ambient) and climate change (CC) conditions (2 °C above ambient temperatures, 940 ppm pCO2). Survivorship in all F2 treatments (ranging from all generations being held at ambient conditions to all at elevated conditions) was high (> 50%). Some significant differences in survivorship existed among treatments, although there was no apparent relationship to CC conditions exposure time. There was also no difference in size among treatment groups in the F2 sea urchins up to 720d post-settlement. As in previous generations, the largest effect on adults was that males exposed to CC conditions have reduced reproductive potential, and there was a significant negative relationship with the number of generations exposed to future ocean conditions and spawning performance. Effects were extreme, in that we could only raise larvae from the control treatment, or those individuals kept for 0.5 generations (only F2 adults under climate change conditions). Larvae from both parental groups only reached settlement when raised under control conditions. Larval morphology also responded to treatment (reduced arm length under CC conditions) and exhibited negative parental effects (smaller arm and body lengths from parents under CC conditions). Thus, negative parental effects observed in earlier publications did not diminish over the following generations but, in some traits, increased. We therefore detected no evidence of transgenerational acclimation to future ocean conditions.
Sharp quantitative stability of Poincaré-Sobolev inequality in the hyperbolic space and applications to fast diffusion flows
Authors: Bhakta Mousomi , Ganguly Debdip , Karmakar Debabrata , Mazumdar Saikat 
Published: December 2024

Abstract
Consider the Poincaré-Sobolev inequality on the hyperbolic space: for every

$$n \ge 3$$

n
≥
3

and

$$1 < p \le \frac{n+2}{n-2},$$

1
<
p
≤

n
+
2

n
-
2

,

there exists a best constant

$$S_{n,p, \lambda }({\mathbb {B}}^{n})>0$$

S

n
,
p
,
λ

(

B

n

)

>
0

such that

$$\begin{aligned} S_{n, p, \lambda }({\mathbb {B}}^{n})\left( ~\int \limits _{{\mathbb {B}}^{n}}|u|^{{p+1}} \, \textrm{d}v_{{\mathbb {B}}^n} \right) ^{\frac{2}{p+1}} \le \int \limits _{{\mathbb {B}}^{n}}\left( |\nabla _{{\mathbb {B}}^{n}}u|^{2}-\lambda u^{2}\right) \, \textrm{d}v_{{\mathbb {B}}^n}, \end{aligned}$$

S

n
,
p
,
λ

(

B

n

)

∫

B

n

|
u
|

p
+
1

d

v

B

n

2

p
+
1

≤

∫

B

n

|

∇

B

n

u
|

2

-
λ

u
2

d

v

B

n

,

holds for all

$$u\in C_c^{\infty }({\mathbb {B}}^n),$$

u
∈

C
c
∞

(

B

n

)

,

and

$$\lambda \le \frac{(n-1)^2}{4},$$

λ
≤

(
n
-
1
)

2

4

,

where

$$\frac{(n-1)^2}{4}$$

(
n
-
1
)

2

4

is the bottom of the

$$L^2$$

L
2

-spectrum of

$$-\Delta _{{\mathbb {B}}^n}.$$

-

Δ

B

n

.

It is known from the results of Mancini and Sandeep (Ann. Sc. Norm. Super. Pisa Cl. Sci. 7 (4): 635–671, 2008) that under appropriate assumptions on n, p and

$$\lambda $$

λ

there exists an optimizer, unique up to the hyperbolic isometries, attaining the best constant

$$S_{n,p,\lambda }({\mathbb {B}}^n).$$

S

n
,
p
,
λ

(

B

n

)

.

In this article, we investigate the quantitative gradient stability of the above inequality and the corresponding Euler-Lagrange equation locally around a bubble. Our result generalizes the sharp quantitative stability of Sobolev inequality in

$${\mathbb {R}}^{n}$$

R

n

by Bianchi and Egnell (J. Funct. Anal. 100 (1): 18–24. 1991) and Ciraolo, Figalli and Maggi (Int. Math. Res. Not. IMRN (21): 6780–6797, 2018) to the Poincaré-Sobolev inequality on the hyperbolic space. Furthermore, combining our stability results and implementing a novel and refined smoothing estimates in spirit of Bonforte and Figalli (Comm. Pure Appl. Math. 74 (4): 744–789, 2021), we prove a quantitative extinction rate towards its basin of attraction of the solutions of the sub-critical fast diffusion flow for radial initial data. In another application, we derive sharp quantitative stability of the Hardy-Sobolev-Maz’ya inequalities for the class of functions which are symmetric in the component of singularity.
Good practice in lactation counseling for Ukrainian refugee mothers to ensure the health and mental benefits of breastfeeding – an observational study
Authors: Babiszewska-Aksamit Magdalena , Bzikowska-Jura Agnieszka , Kotlińska Anna , Aduła Agata , Chrobak Agnieszka , Domosud Justyna , Drążkowska Izabela , Gaweł Paulina , Jakimiuk Artur , Kołodziej Józefa , Królak-Olejnik Barbara , Lisak-Gurba Katarzyna , Mozdyniewicz Katarzyna , Mołas Aleksandra , Piątkowska Agnieszka , Sinkiewicz-Darol Elena , Wesołowska Aleksandra 
Published: December 2024

Abstract
Purpose
The study presents a cross-sectional analysis of the population of Ukrainian women who received maternity care in 11 Polish hospitals.

Methods
Multidirectional lactation counseling was implemented from March to November 2023 by the Human Milk Bank Foundation in cooperation with UNICEF Refugee Response Office in Poland. Medical data were collected using questionnaires prepared for the study. When the mother indicated that she had mental problems or the health care personnel spotted problems, she was she referred to a psychologist for diagnostics, who used questionnaires appropriate to the patient’s situation such as: Patient Health Questionnaire-9 for depression assessment and Generalized Anxiety Disorder Questionnaire-7 for anxiety assessment.

Results
In total, 1203 consultations were carried out, of which 542 were lactation counseling, 305 - were physiotherapy, 227 - were psychological, and 129 - were with speech-language pathologists. Two hours of skin-to-skin contact (SSC) and latching on the breast within the 1st hour postpartum occurred in more than half of the participants. In the rest of the population, shortened or lack of SSC was associated with breastfeeding delayed by at least one day. 53% of the population required lactation counseling, of which 242 were one-time visits. Continued support was 98% effective in achieving breastfeeding goals. 167 mothers required psychological support, of which only 53 women continued treatment beyond one-time counseling. Only about 1% of women experienced mental disorders based on a psychological interview.

Conclusion
The use of lactation counseling more often than psychological counseling by refugee mothers could be related to the beneficial effects of breastfeeding on maternal well-being through hormonal self-regulation and empowerment as a mother. However, focused research is needed on the impact of breastfeeding on the mental health of refugee women.
Examining the presence and effects of coherence and fragmentation in the Gulf of Maine fishery management network
Authors: Katznelson Derek , Sohns Antonia , Kim Dongkyu , Roozee Evelyn , Donner William R. , Song Andrew M. , de Vries Jasper R. , Temby Owen , Hickey Gordon M. 
Published: December 2024

AbstractNatural resource management networks cohere due to mutual dependencies and fragment, in part, due to the perceived risks of interaction. However, research on these networks has tended to accept coherence a priori rather than problematizing dependence, and few studies exist on interorganizational risk perception. This article presents the results of a study operationalizing these concepts and measuring the distribution of three types of dependence (capital, legitimacy, and regulatory) and two types of perceived risk (performance and sanction) among nearly fifty stakeholder groups and organizations participating in the management of fisheries in the binational Gulf of Maine. The analysis reveals an organizationally diverse network with several stakeholder types participating, with communications clustered binationally, with low levels of perceived risk in interacting, and interdependencies cohering the network. The types of interorganizational dependence present varied across dyadic relationships, but legitimacy dependence, based on shared understandings that organizations should work together, was the most present and had the largest effect on collaboration-oriented network traits. Sanction risk was more common than performance risk but had the most substantial negative effect. The results suggest an opportunity for additional studies of interorganizational dependance and perceived risk to operationalize and measure the sources of network coherence and fragmentation and their effect on collaboration.
Diagnostic accuracy of intraoperative pelvic autonomic nerve monitoring during rectal surgery: a systematic review
Authors: O’Connor A. , Rengifo C. , Griffiths B. , Cornish J. A. , Tiernan J. P. , Khan Jim , Nunoo-Mensah J. W. , Telford K. , Harji D. 
Published: December 2024

Abstract
Purpose
Anorectal and urogenital dysfunctions are common after rectal surgery and have a significant impact on quality of life. Intraoperative pelvic autonomic nerve monitoring (pIONM) has been proposed as a tool to identify patients at risk of these functional sequelae. This systematic review aims to evaluate the diagnostic accuracy of pIONM in detecting anorectal and urogenital dysfunction following rectal surgery.

Methods
A systematic review of articles published since 1990 was conducted using MEDLINE, Embase, CINAHL, Google Scholar, Scopus, and Web of Science. Studies describing pIONM for rectal surgery and reporting anorectal or urogenital functional outcomes were included. The risk of bias was assessed using the QUADS-2 tool. The diagnostic accuracy of pIONM was established with pooled sensitivity and specificity alongside summary receiver-operating characteristic curves.

Results
Twenty studies including 686 patients undergoing pIONM were identified, with seven of these studies including a control group. There was heterogeneity in the pIONM technique and reported outcome measures used. Results from five studies indicate pIONM may be able to predict postoperative anorectal (sensitivity 1.00 [95% CI 0.03–1.00], specificity 0.98 [0.91–0.99]) and urinary (sensitivity 1.00 [95% CI 0.03–1.00], specificity 0.99 [0.92–0.99]) dysfunction.

Conclusions
This review identifies the diagnostic accuracy of pIONM in detecting postoperative anorectal and urogenital dysfunction following rectal surgery. Further research is necessary before pIONM can be routinely used in clinical practice.

PROSPERO Registration Details
CRD42022313934.
Tailings Dam Breach Outflow Modelling: A Review
Authors: Sreekumar Uthra , Gildeh Hossein Kheirkhah , Mohammadian Abdolmajid , Rennie Colin , Nistor Ioan 
Published: December 2024

AbstractTailings dam breach modelling studies have received considerable attention recently due to the rise in the number of tailings dam failures and catastrophic consequences caused by downstream flooding. Numerical models are useful tools in risk management for assisting urban planners in planning for the safe evacuation of the vulnerable communities located downstream in the so-called “shadow area” of such dams. Several challenges and uncertainties exist when conducting risk assessments of tailings dam failure. In this study, recent advances in modelling approaches for tailings dam breach analysis and downstream flood wave routing are summarized and critically reviewed. This study evaluates different mudflow modelling studies that involve single-phase, quasi-two-phase, and two-phase modelling approaches; dam breach outflow modelling; tailings rheological characterization; and application of geographic information system (GIS) and remote sensing to tailings dam breach analysis. Recommendations for further research are provided based on the findings. In addition, this study will help dam engineers and practitioners to maintain industry standards and include state-of-the-art practices in their work.
Patient-Centered Communication: Incorporating Principles of Dialogic Practice and Family Centered Rounds on an Inpatient Psychotic Disorders Unit
Authors: Gerken Adrienne T. , Öngür Dost , Kim Soo Jin , Ren Boyu , Idiculla Thomaskutty , Stoklosa Joseph 
Published: December 2024

Abstract
This study examined the impact of Patient-Centered Communication (PCC), Open Dialogue-inspired changes to rounding practices and culture, on patient perceptions of care on an inpatient psychotic disorders unit. A retrospective cohort analysis was conducted based on medical records, restraint and seclusion records, and hospital Perceptions of Care (PoC) surveys. The analysis compared data from 6-month periods before and after implementation of PCC to quantify whether the implementation of PCC was associated with more positive care ratings. There were trends toward improvement suggestive of an effect on patients’ perception that their care was adequately explained, that they felt involved in care, that they felt respected, and that they were supported during hospitalization, although improvements did not achieve statistical significance. Greater improvement was observed for teams that incorporated a greater number of interventions. Dialogic practice-inspired changes on an acute inpatient unit may improve patient perceptions of inclusion and respect in their care.
SARS-CoV-2 Prevalence in a Delivering Refugee Population: Refugee Status, Payor Type, Race, and Vaccination Status
Authors: Johnston Eleanor U. , Bhattarai Bikash , Johnson-Agbakwu Crista E. , Coonrod Dean V. 
Published: December 2024

Abstract
Underserved communities were disproportionately affected during the coronavirus (COVID-19) pandemic. Limited data exist on the impact of COVID-19 among refugee populations because refugee status is not often classified in electronic medical record (EMR) systems, unlike race or primary language. The study aim was to evaluate the PCR-based prevalence of SARS-CoV-2 in a delivering population over the first 2 years of the pandemic by refugee status, ethnicity, insurance, and vaccination status. A cross-sectional study examined parturient patients admitted to an urban safety-net hospital from May 2020 to May 2022 who were tested for SARS-CoV-2on admission. Percentages and prevalence ratios of SARS-CoV-2 between refugee status, insurance type, vaccination status, and race/ethnicity were calculated across four time periods, corresponding with variant surges of the pandemic. 3,502 patients delivered, 476 (13.6%) were refugees. Self-pay (46.4%) and Medicaid (46.4%) were the most frequent insurance types with a Hispanic predominance (64.5%) by race/ethnicity. Only 12.8% of patients received at least one vaccine before delivery: 13.2% in non-refugees versus 10.3% refugees 192 (5.5%) of the mothers tested positive during the study period with 6.1% refugees positive versus 5.4% among non-refugees, (prevalence ratio, 1.13; P = 0.53, 95% confidence interval [0.77, 1.66]). Positive tests ranged between 4.7% and 6.3% across insurance types and between 4.4% and 7.5% across race/ethnicity categories. The highest prevalence ratio (refugee/non-refugee) of 2.01 was during the Delta Surge (P = 0.12, 95% confidence interval [0.84, 4.82]) and the lowest prevalence ratio of 0.64 was during the Omicron Surge (P = 0.21, 95% CI [0.32, 1.30]). Among refugees when examined by primary language, 51.7% of positive tests were from those speaking languages of the African Great Lakes region (Kinyarwanda, Kirundi, Swahili, Kiswahili). We observed only small differences in SARS-CoV-2 prevalence between refugees and non-refugees or in vaccination status. Variations in prevalence ratio were seen by refugee status by variant surge. Subsets of the refugee population, when grouped by language/region, appeared to be more affected. This warrants future research on the impact of the SARS-CoV-2 pandemic on specific refugee communities, rather than refugee communities as a heterogenous unit.