bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endotracheal tube obstruction with a blood clot following aspiration of rumen contents in a reindeer
Authors: Lehnus Kristina 
Published: July 2018

SummaryAn apparently otherwise healthy female reindeer was anaesthetised for open reduction and fixation of a hip luxation. The animal developed ruminal bloat which was treated with passage of an orogastric tube that was left indwelling during the procedure. A fluid inspiratory noise was audible two hours after decompression, and clear fluid was suctioned from the airway. It showed no other signs of regurgitation and aspiration of rumen contents intraoperatively, and did not develop obvious respiratory compromise while mechanically ventilated. In recovery, the deer became apnoeic and cyanotic and died suddenly within minutes of being positioned in the recovery box. Just before dying, it coughed a large blood clot out of the endotracheal tube (ETT) . Additional clots were found partially obstructing the ETT lumen once extubated postmortem. Evidence of aspiration was detected at postmortem examination, which also identified pulmonary haemorrhage.
Extracorporeal membrane oxygenation in acute massive pulmonary embolism: a case series and review of the literature
Authors: Al-Bawardy Rasha , Rosenfield Kenneth , Borges Jorge , Young Michael N. , Albaghdadi Mazen , Rosovsky Rachel , Kabrhel Christopher 
Published: July 2018

Background: Extracorporeal membrane oxygenation (ECMO) has been used to stabilize patients with massive pulmonary embolism though few reports describe this approach. We describe the presentation, management and outcomes of patients who received ECMO for massive pulmonary embolism (PE) in our pulmonary embolism response team (PERT) registry. Methods: We enrolled a consecutive cohort of patients with confirmed PE for whom PERT was activated and selected patients treated with ECMO. We prospectively captured clinical, therapeutic and outcome data at the time of PERT activation and during the follow-up period for up to 365 days. Results: Thirteen patients who had PERT activation with confirmed PE diagnosis have undergone ECMO since the initiation of our PERT program in 2012. The mean age was 49 ± 19 years. Six (46%) patients were female. All the patients had cardiac arrest, either as an initial presentation or in-hospital cardiac arrest after presentation. All the patients exhibited right ventricular (RV) dilation on echocardiogram with RV hypokinesis. Eight (62%) patients received systemic thrombolysis with intravenous tissue plasminogen activator (tPA) and three (23%) patients underwent catheter-directed thrombolysis therapy using the EKOS system (EKOS Corporation, Bothell, WA, USA). Four (31%) patients underwent surgical embolectomy. Mean ECMO duration was 5.5 days, ranging from 2-18 days. Thirty-day mortality was 31% and one-year mortality was 54%. Conclusions: Patients with massive pulmonary embolism who suffer a cardiac arrest have high morbidity and mortality. ECMO can be used in conjunction with systemic thrombolysis, catheter-directed therapy or as a bridge to surgical embolectomy.
Transculturalized Diversity and Inclusion Model: A New Framework for Disabilities
Authors: Thoms Charlotte L. V. , Burton Sharon L. 
Published: July 2018

The Problem After 30+ years of debating the best model for disability, there is a need for a new framework. As the medical model of disability seeks a cure and the social model points to the environment, neither model is without its flaws. Human resource development (HRD) professionals and practitioners are in a position to craft a model that reflects the experiences of people with disabilities. This new model will strengthen HRD’s importance in the field and its impact on other disciplines. The Solution This article offers consideration to be given for a new model for disability that addresses the complexities of cultural boundaries, gives value to the experiences of people with disabilities, and changes language in how disabilities are described. Using the results of the literature review, a path to the Transculturalized Diversity and Inclusion Model lays the groundwork for further research. This article accesses the perceptions of people with disabilities regarding both models, incorporates the strategies used by HRD scholars and researchers for improving value in a growing population of disabled people, and synthesizes a platform for future discussion and development of the Transculturalized Diversity and Inclusion Model. The Stakeholders HRD practitioners, especially those serving populations with disabilities, will benefit greatly from a new model and perspective provided by the Transculturalized Diversity and Inclusion Model. HRD scholars likewise will be provided with a new framework for conducting research on people with disabilities in the workplace.
Return to work recommendations after carpal tunnel release: a survey of UK hand surgeons and hand therapists
Authors: Newington Lisa , Francis Kristin , Ntani Georgia , Warwick David , Adams Jo , Walker-Bone Karen 
Published: July 2018

There is a limited evidence base from which to derive recommendations for safe and effective return to different types of occupation after carpal tunnel release surgery. The current practice of members of the British Society for Surgery of the Hand and the British Association of Hand Therapists was investigated with a questionnaire. In total, 173 surgeons and 137 therapists responded from an estimated sample of 1959. Median recommended return-to-work times were 7 days for desk-based duties, 15 days for repetitive light manual duties and 30 days for heavy manual duties. However, the responses were wide-ranging: 0–30 days for desk-based; 1–56 days for repetitive light manual; and 1–90 days for heavy manual. Variation in the recommended timescales for return to work and other functional activities after carpal tunnel release suggests that patients are receiving different and possibly even conflicting advice. Level of evidence: V
What do hospitalists experience as barriers and helpful factors for having ACP conversations? A systematic qualitative evidence synthesis
Authors: Vanderhaeghen Birgit , Van Beek Karen , De Pril Mieke , Bossuyt Inge , Menten Johan , Rober Peter 
Published: July 2018

Background: Hospitalists seem to struggle with advance care planning implementation. One strategy to help them is to understand which barriers and helpful factors they may encounter. Aims: This review aims to give an overview on what hospitalists experience as barriers and helpful factors for having advance care planning conversations. Method: A systematic synthesis of the qualitative literature was conducted. Data sources: A bibliographic search of English peer-reviewed publications in PubMed, Embase, CINAHL, Central, PsycINFO, and Web of Science was undertaken. Results: Hospitalists report lacking communication skills which lead to difficulties with exploring values and wishes of patients, dealing with emotions of patients and families and approaching the conversation about letting a patient die. Other barriers are related to different interpretations of the concept advance care planning, cultural factors, like being lost in translation, and medicolegal factors, like fearing prosecution. Furthermore, hospitalists report that decision-making is often based on irrational convictions, and it is highly personal. Physician and patient characteristics, like moral convictions, experience, and personality play a role in the decision-making process. Hospitalists report that experience and learning from more experienced colleagues is helpful. Furthermore, efficient multidisciplinary co-operation is helping. Conclusion: This systematic review shows that barriers are often related to communication issues and the convictions of the involved hospitalist. However, they seem to be preventable by creating a culture where experienced professionals can be consulted, where convictions can be questioned, and where co-operation within and between organizations is encouraged. This knowledge can serve as a basis for implementation.
PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells
Authors: Yin Linglong , Liu Youhong , Peng Yuchong , Peng Yongbo , Yu Xiaohui , Gao Yingxue , Yuan Bowen , Zhu Qianling , Cao Tuoyu , He Leye , Gong Zhicheng , Sun Lunquan , Fan Xuegong , Li Xiong 
Published: July 2018

Abstract
Background
The poly ADP ribose polymerase (PARP) inhibitor olaparib has been approved for treating prostate cancer (PCa) with BRCA mutations, and veliparib, another PARP inhibitor, is being tested in clinical trials. However, veliparib only showed a moderate anticancer effect, and combination therapy is required for PCa patients. Histone deacetylase (HDAC) inhibitors have been tested to improve the anticancer efficacy of PARP inhibitors for PCa cells, but the exact mechanisms are still elusive.

Methods
Several types of PCa cells and prostate epithelial cell line RWPE-1 were treated with veliparib or SAHA alone or in combination. Cell viability or clonogenicity was tested with violet crystal assay; cell apoptosis was detected with Annexin V-FITC/PI staining and flow cytometry, and the cleaved PARP was tested with western blot; DNA damage was evaluated by staining the cells with γH2AX antibody, and the DNA damage foci were observed with a fluorescent microscopy, and the level of γH2AX was tested with western blot; the protein levels of UHRF1 and BRCA1 were measured with western blot or cell immunofluorescent staining, and the interaction of UHRF1 and BRCA1 proteins was detected with co-immunoprecipitation when cells were treated with drugs. The antitumor effect of combinational therapy was validated in DU145 xenograft models.

Results
PCa cells showed different sensitivity to veliparib or SAHA. Co-administration of both drugs synergistically decreased cell viability and clonogenicity, and synergistically induced cell apoptosis and DNA damage, while had no detectable toxicity to normal prostate epithelial cells. Mechanistically, veliparib or SAHA alone reduced BRCA1 or UHRF1 protein levels, co-treatment with veliparib and SAHA synergistically reduced BRCA1 protein levels by targeting the UHRF1/BRCA1 protein complex, the depletion of UHRF1 resulted in the degradation of BRCA1 protein, while the elevation of UHRF1 impaired co-treatment-reduced BRCA1 protein levels. Co-administration of both drugs synergistically decreased the growth of xenografts.

Conclusions
Our studies revealed that the synergistic lethality of HDAC and PARP inhibitors resulted from promoting DNA damage and inhibiting HR DNA damage repair pathways, in particular targeting the UHRF1/BRCA1 protein complex. The synergistic lethality of veliparib and SAHA shows great potential for future PCa clinical trials.
Use of a novel chitosan-based dressing on split-thickness skin graft donor sites: a pilot study
Authors: Varon David E. , Smith Jessica D. , Bharadia Deepak R. , Shafique Neha , Sakthivel Dharaniya , Halvorson Eric G. , Nuutila Kristo , Sinha Indranil 
Published: July 2018

Objective: Split-thickness skin graft (STSG) donor site dressings can play an integral role in reducing donor site morbidity. This study tested a novel, chitosan-based wound dressing, Opticell Ag, as an STSG donor site dressing for wounds <10% total body surface area (TBSA). Method: Between January and December 2016, the chitosan-based dressing was placed on participating patients' donor sites immediately following graft harvest and covered with a transparent occlusive dressing. Pain was evaluated on postoperative day one, before dressing change between days 5–7, and before and after dressing removal between days 10–14 using the Visual Analog Scale (VAS). The extent of re-epithelialisation was determined between day 10–14 and at one month, and healing quality was also evaluated at one month post-operatively using the Vancouver Scar Scale (VSS). Results: A total of 19 patients were recruited, of which 16 completed the study. Patients experienced mild-to-moderate pain in their donor sites when the chitosan-based dressing was used. Pain decreased significantly between postoperative day one and days 10–14, as well as between days 5–7 and 10–14. The mean percentage of re-epithelialisation on days 10–14 was 92% and by one month was 99%. The mean VSS at one month was 3.2±1.4. There were no statistically significant differences between patients' re-epithelialisation rates or VSS scores. There were unplanned dressing changes in four patients. No donor site infections or other adverse events were identified. Conclusion: The chitosan-based dressing tested in this study is safe, effective, and associated with reasonable pain control and acceptable healing quality. The results suggest that it is a promising STSG donor site dressing.
Efficacy of a nitric oxide dressing in decreasing bacterial counts on human skin
Authors: Nye Rachel , Robinia Kristi , Peterson Paul , Jodoin Zachary , Bohm Margaret , Anderman Meghan , Peacock Tess , Moody Madison , Naimi Alyssa , Sharp Josh 
Published: July 2018

Objective: Inhibiting the proliferation of skin bacteria, using nitric oxide (NO), is a potential strategy to prevent infections. This study evaluated the efficacy of using a new NO releasing film dressing to decrease resident human bacterial skin flora compared with the measured microbial activity underneath control sterile Tegaderm transparent dressings. Methods: A within-subjects design using a sample of convenience compared the bacterial counts under the skin of experimental dressings to those under control dressings. NO releasing film dressings (three) and control dressings (three) were applied without antiseptic preparation to the intact skin on the backs of 67 healthy volunteers. Subsequent skin cultures were obtained from underneath dressing pairs (one experimental and one control) on days three, five, and seven after application. Baseline microflora bacterial counts from uncovered skin was obtained on day three of the study. Comparisons of bacterial counts were analysed. Results: On days three, five and seven, the experimental NO releasing film dressings demonstrated a statistically significant reduction in bacterial count compared with the control dressings. Conclusion: The NO releasing film dressings resulted in significantly lower bacterial colony counts as compared to the control dressings at all time points. Incorporating a NO compound into a dressing has an antibacterial effect lasting a minimum of seven days.
Factors in facilitating an organisational culture to prevent pressure ulcers among older adults in health-care facilities
Authors: Stadnyk Brandy , Mordoch Elaine , Martin Donna 
Published: July 2018

Objective: Despite the availability of high-quality clinical practice guidelines, pressure ulcers (PU) continue to develop among older adults in acute and long-term health-care facilities. Except during acute medical crisis or near end-of-life, most PUs are preventable and their development is a health-care quality indicator. The aim of this study was to understand which factors facilitate pressure ulcer prevention among adults over 65 years-of-age receiving care in health-care facilities. Method: A critical literature review from three scholarly databases examined components of organisational culture associated with PU prevention. Research papers involving adults >65 years-of-age who were admitted to acute and long-term health-care facilities with PU prevention programmes between 2010 and 2017 were included. A secondary manual search included literature discussing health-care organisational culture, with a total of 41 articles reviewed. Results: Based on a synthesis of this literature, the Factors Facilitating Pressure Ulcer Prevention Model was developed to depict five multilevel factors for PU prevention among older adults in health-care facilities. These five factors are: senior leadership, education, ongoing quality improvement, clinical practice, and unit level champions. Conclusion: Ongoing prioritisation of these factors sustains PU prevention and assists health-care facilities to redefine their culture, expand education programmes, and promote accountability to improve health outcomes of older adults receiving care.
Antzuola Herri Eskola. Eskola ongizatearen eraikuntzan kontzeptua mugatuz eta zabalduz
Authors: Basasoro Ciganda Maitane , Karrera Juarros Iñaki , Arguiñano Madrazo Andoni 
Published: July 2018

Hezkuntzako erronka nagusienetako bat egungo aniztasunari modu positiboan aurre egin eta inklusiora bidea irekitzea da. Bide honetan, hezkuntzako marko legalak dio gizabanakoen ongizatea bermatu behar duela eskola inklusiboak. Horretarako, eskola ongizatearen garrantzia azpimarratzen da lan honetan, zehazki eskola ongizatea komunitateko kide ororentzako espazio aproposago bat bilatzeko bidean martxan jartzen diren ezaugarri multzo gisa ulertuz. Lan honetan, ongizatea helburu nagusitzat duen eskola bat aztertu ondoren, eskola ongizateak besteak beste biltzen dituen ezaugarri multzo bat osatu nahi izan da lehenik, eta eskola inklusiboa eta eskola ongizatea elkar lotuta doazen kontzeptuak direla argitu nahi izan da bestetik.Gako hitzak: inklusioa, eskola inklusiboa, ongizatea, eskola ongizatea, berrikuntza pedagogikoa.
Ukuran rongga udara, pH telur dan diameter putih telur, ayam ras (Gallus L.) setelah pencelupan dalam larutan rumput laut dan disimpanan beberapa waktu
Authors: Djaelani Muhammad Anwar 
Published: July 2018

Telur ayam merupakan sumber protein hewani yang murah dan mudah untuk didapatkan oleh masyarakat Indonesia. Senyawa penyusun telur merupakan bahan organik yang mudah rusak. Salah satu faktor yang menyebabkan rusaknya telur adalah lama waktu penyimpanan . Penelitian ini bertujuan untuk menganalisis kualitas telur ayam berdasar ukuran rongga udara, pH telur dan diameter putih telur setelah pencelupan dalam larutan rumput laut . Sampel yang digunakan adalah telur ayam ras yang diambil pada hari pertama telur dioviposisikan. Digunakan Rancangan acak lengkap dengan 9 kelompok perlakuan yaitu P0 sampel disimpan pada suhu kamar tanpa perlakuan, diamati pada hari ke 1, P1 sampel disimpan pada suhu kamar tanpa perlakuan, diamati pada hari ke 7, P2 sampel dicelupkan ke dalam larutan rumput laut sebelum disimpan pada suhu kamar, diamati pada hari ke 7. P3 sampel disimpan pada suhu kamar tanpa perlakuan, diamati pada hari ke 14. P4 sampel dicelupkan ke dalam larutan rumput laut sebelum disimpan pada suhu kamar, diamati pada hari ke 14, P5 sampel disimpan pada suhu kamar tanpa perlakuan, diamati pada hari ke 21, P6 sampel dicelupkan ke dalam larutan rumput laut sebelum disimpan pada suhu kamar, diamati pada hari ke 21, P7 sampel disimpan pada suhu kamar tanpa perlakuan, diamati pada hari ke 28, P8 sampel dicelupkan ke dalam larutan rumput laut sebelum disimpan pada suhu kamar, diamati pada hari ke 28. Data yang diperoleh dianalisis menggunakan ANOVA dengan taraf signifikansi 5%. Hasil penelitian menunjukkan semua variabel penelitian menunjukkan penurunan seiring dengan bertambahnya waktu penyimpanan. Pencelupan ke dalam rumput laut tidak mampu mepertahankan kualitas telur Penurunan kualitas kemungkinan disebabkan faktor lamanya penyimpanan yang menyebabkan perubahan kondisi telur. Kata kunci : Penyimpanan telur, Diameter Putih Telur, rongga udara, pH telur
Pengaruh Waktu Fermentasi Teh Kombucha Kadar 75% terhadap Profil Lipid Tikus Putih
Authors: Isdadiyanto Sri , Tana Silvana 
Published: July 2018

Tujuan penelitian ini untuk mengetahui pengaruh pemberian teh kombucha kadar 75% sebagai drinking water dengan variasi waktu fermentasi. Penelitian ini menggunakan Tikus putih (Rattus norvegicus) jantan sebanyak 16 ekor umur 2 bulan, dengan perlakuan Teh kombucha yang difermentasi selama 6, 9 dan 12 hari pada suhu 25oC per oral. Penelitian ini menggunakan Rancangan Acak Lengkap dengan 4 perlakuan (selama 28 hari) dan 4 ulangan, yaitu : P0 = kontrol, tanpa tambahan teh kombucha, P1 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 6 hari, P2 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 9 hari, P3 = air minum + 1,8 ml teh kombucha pagi dan sore fermentasi 12 hari. Variabel yang diukur adalah kadar kolesterol, HDL dan LDL. Data yang diperoleh dianalisis menggunakan ANOVA yang dilanjutkan dengan Uji Duncan dengan taraf kepercayaan 95% dengan menggunakan perangkat lunak SPSS 10,0. Hasil penelitian menunjukkan bahwa pemberian teh kombucha dapat menaikkan kadar HDL, menurunkan kadar kolesterol dan LDL serum darah tikus putih (Rattus norvegicus). Kata kunci: Rattus norvegicus, teh kombucha kadar 75%, kolesterol, HDL, LDL
Perubahan Histologi dan Fisiologi Latisifer pada Tanaman Karet (Hevea brasiliensis Muell Arg.) yang diberi Asam Jasmonat dan Asam Naftalen Asetat Eksogen
Authors: Tistama Radite , Lubis Vahnoni , Nurwahyuni Isnaini 
Published: July 2018

Produktivitas tanaman karet tergantung pada faktor dominan seperti jumlah latisifer dan aktivitas metabolism lateks. Perkembangan histologi dan fisiologi latisifer tanaman karet dipengaruhi oleh jenis klon dan interaksi antara zat pengatur tumbuh eksogen dengan klon. Perubahan histologi dan fisiologi latisifer Hevea brasiliensis diteliti dengan aplikasi asam jasmonat, asam naftalen asetat dan kombinasi keduanya pada permukaan tunas lateral muda. Hasil penelitian ini menunjukkan bahwa zat pengatur tumbuh menginduksi jumlah pembuluh kateks tetapi mengurangi perkembangan tebal kulit dan ukuran sel latisifer. Kombinasi JA dengan NAA paling efektif menginduksi jumlah pembuluh lateks pada klon metabolisme tinggi PB 260. Zat pengatur tumbuh memacu perubahan aktivitas fisiologi pada klon metabolisme rendah IRR 42. Analisis histologi kulit dan fisiologi lateks pada tunas muda tanaman karet dapat digunakan sebagai pendeteksi potensi produktivitas dan sifat metabolisme tanaman karet. Kata kunci: Latisifer Hevea, asam jasmonat, asam naftalen asetat, metabolisme lateks
Penerapan Wanamina: Kelulushidupan Semai Mangrove, Variasi Kualitas Lingkungan dan Perubahan Kandungan Logam Berat
Authors: Hastuti Endah Dwi 
Published: July 2018

Penerapan wanamina dalam budidaya tambak diharapkan memberikan perbaikan bagi lingkungan oleh adanya jasa-jasa lingkungan yang disediakan oleh tegakan mangrove. Penelitian ini bertujuan untuk mengkaji tingkat kelulushidupan semai mangrove, dampak wanamina terhadap tingkat kekeruhan dan kandungan TDS serta menganalisis perubahan kandungan logam berat dalam sedimen saluran tambak wanamina. Penelitian dilakukan selama 2 bulan pada tambak wanamina dengan perlakuan lebar saluran 1 m, 2 m dan 3 m dengan jenis mangrove A. marina dan R. mucronata dengan jarak tanam 1 x 1 m2. Pengamatan terhadap tingkat kelulushidupan, tingkat kekeruhan dan kandungan TDS dilakukan pada akhir pengamatan, sedangkan kandungan Pb dan Cd dalam sedimen diamati pada awal dan akhir penelitian. Hasil penelitian menunjukkan bahwa tingkat kelulushidupan R. mucronata dalam saluran tambak wanamina lebih baik yaitu berkisar antara 80 – 90% dibandingkan A. marina yang berkisar 0 – 85%. Kekeruhan secara signifikan berbeda berdasarkan lebar saluran sedangkan TDS secara signifikan dipengaruhi oleh lebar saluran dan jenis mangrove secara parsial. Perubahan kandungan Pb tidak dipengaruhi secara signifikan baik oleh lebar saluran maupun jenis mangrove, namun terdapat pola akumulasi yang berlawanan antara kedua jenis mangrove, sedangkan perubahan kandungan Cd secara signifikan dipengaruhi oleh lebar saluran dimana pada saluran dengan lebar 2 m memiliki tingkat akumulasi paling tinggi. Kata kunci : kekeruhan, kelulushidupan, logam berat, TDS, wanamina