bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Urinary Tract Infection Management by Pharmacists (RxOUTMAP): A study of pharmacist prescribing and care in patients with uncomplicated urinary tract infections in the community
Authors: Beahm Nathan P. , Smyth Daniel J. , Tsuyuki Ross T. 
Published: June 2018

Background: Pharmacists have the authorization to prescribe medications for the treatment of uncomplicated urinary tract infections (UTI) in some provinces. However, there are limited data on the outcomes of this care by pharmacists. Our objective was to evaluate the effectiveness, safety and patient satisfaction with pharmacist prescribing and care in patients with uncomplicated UTI. Methods: We conducted a prospective registry trial in 39 community pharmacies in the Canadian province of New Brunswick. Adult patients were enrolled if they presented to the pharmacy with either symptoms of UTI with no current antibacterial treatment (Pharmacist-Initial Arm) or if they presented with a prescription for an antibacterial to treat UTI from another health care provider (Physician-Initial Arm). Pharmacists assessed patients and if they had complicating factors or red flags for systemic illness or pyelonephritis, they were excluded from the study. Pharmacists either prescribed antibacterial therapy, modified antibacterial therapy, provided education only or referred to physician, as appropriate. The primary outcome was clinical cure at 2 weeks and the secondary outcomes included adverse events and patient satisfaction. Results: A total of 750 patients were enrolled (87.4% in the Pharmacist-Initial Arm), average age was 40.9 (SD 16.0) years. Clinical cure was achieved in 88.9% of patients. Of those that did not have sustained symptom resolution, most (5.5% overall) had symptom recurrence after completion of therapy. Adverse events were reported by 7.2% of patients and 88.9% of those continued their medication. Most adverse events were gastrointestinal-related and transient. The patient satisfaction survey reflected very high levels of satisfaction for the care they received, as well as for trust and accessibility of the pharmacist. Conclusion: Pharmacist management of uncomplicated UTI is effective, safe, and patient satisfaction appears very high.
Improving communication with older patients with cancer using geriatric assessment (GA): A University of Rochester NCI Community Oncology Research Program (NCORP) cluster randomized controlled trial (CRCT).
Authors: Mohile Supriya Gupta , Epstein Ronald M. , Hurria Arti , Heckler Charles E. , Duberstein Paul , Canin Beverly E. , Gilmore Nikesha , Wells Megan , Xu Huiwen , Culakova Eva , Lowenstein Lisa M. , Flannery Marie Anne , Magnuson Allison , Loh Kah Poh , Mustian Karen Michelle , Hopkins Judith O. , Liu Jijun , Melnyk Nataliya , Morrow Gary R. , Dale William 
Published: June 2018

LBA10003 Background: GA includes validated measures that assess age-related health domains (e.g., function, cognition) known to increase adverse outcomes. In this PCORI and NCI funded CRCT, we evaluated if providing a GA summary and recommendations for GA-guided interventions improves communication about age-related concerns for older patients (pts) with cancer. Methods: Pts aged ≥ 70 with advanced solid tumors or lymphoma and at least 1 impaired GA domain were enrolled. Oncology practices were randomized to intervention (oncologists received GA summary) or usual care (no summary provided). The primary outcomes were: 1) number of discussions about age-related concerns (the clinic visit after GA was audio-recorded and transcribed; 2 blinded coders evaluated quality of communication and plan for follow-up interventions) and 2) telephone surveys of patient satisfaction (modified Health Care Climate Questionnaire [HCCQ-age] scored 7-35). Outcomes were analyzed using linear mixed models with arm as the fixed effect, controlling for practice. Results: From 2014-17, 544 pts (295 in GA) were enrolled from 31 practices. There were no differences in demographics by arm (mean age 77 yrs; 49% female). More patients in usual care had impaired physical performance (96% vs 92%, p = 0.03) and social support (33% vs 25%, p = 0.05). In 530 evaluable pts, the overall mean number of discussions was 6.3 (SD: 4.0). The GA arm had 3.5 more discussions about age-related concerns (95%CI: 2.28-4.72, p = 10-6; intraclass correlation coefficient [ICC] = 0.24) compared to usual care; of these, in the GA arm, 2.0 more discussions on average had higher quality communication (95%CI: 1.20-2.69; p = 6x10-6) and 1.9 more led to interventions (95% CI: 1.14-2.73; p = 1.6x10-5). The GA arm had significantly more discussions for almost all GA domains. In 511 pts with HCCQ-age, the mean score was 22.9 (SD 4.5); the score was 1.12 points higher in the GA arm (95%CI: 0.23-2.03; p = .027; ICC = 0.02). Conclusions: Providing a GA summary to oncologists increases the number and quality of discussions about age-related concerns and improves pt satisfaction. Clinical trial information: NCT02107443.
Phase III Randomized Study of Ribociclib and Fulvestrant in Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced Breast Cancer: MONALEESA-3
Authors: Slamon Dennis J. , Neven Patrick , Chia Stephen , Fasching Peter A. , De Laurentiis Michelino , Im Seock-Ah , Petrakova Katarina , Bianchi Giulia Val , Esteva Francisco J. , Martín Miguel , Nusch Arnd , Sonke Gabe S. , De la Cruz-Merino Luis , Beck J. Thaddeus , Pivot Xavier , Vidam Gena , Wang Yingbo , Rodriguez Lorenc Karen , Miller Michelle , Taran Tetiana , Jerusalem Guy 
Published: June 2018

Purpose This phase III study evaluated ribociclib plus fulvestrant in patients with hormone receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer who were treatment naïve or had received up to one line of prior endocrine therapy in the advanced setting. Patients and Methods Patients were randomly assigned at a two-to-one ratio to ribociclib plus fulvestrant or placebo plus fulvestrant. The primary end point was locally assessed progression-free survival. Secondary end points included overall survival, overall response rate, and safety. Results A total of 484 postmenopausal women were randomly assigned to ribociclib plus fulvestrant, and 242 were assigned to placebo plus fulvestrant. Median progression-free survival was significantly improved with ribociclib plus fulvestrant versus placebo plus fulvestrant: 20.5 months (95% CI, 18.5 to 23.5 months) versus 12.8 months (95% CI, 10.9 to 16.3 months), respectively (hazard ratio, 0.593; 95% CI, 0.480 to 0.732; P < .001). Consistent treatment effects were observed in patients who were treatment naïve in the advanced setting (hazard ratio, 0.577; 95% CI, 0.415 to 0.802), as well as in patients who had received up to one line of prior endocrine therapy for advanced disease (hazard ratio, 0.565; 95% CI, 0.428 to 0.744). Among patients with measurable disease, the overall response rate was 40.9% for the ribociclib plus fulvestrant arm and 28.7% for placebo plus fulvestrant. Grade 3 adverse events reported in ≥ 10% of patients in either arm (ribociclib plus fulvestrant v placebo plus fulvestrant) were neutropenia (46.6% v 0%) and leukopenia (13.5% v 0%); the only grade 4 event reported in ≥ 5% of patients was neutropenia (6.8% v 0%). Conclusion Ribociclib plus fulvestrant might represent a new first- or second-line treatment option in hormone receptor–positive/human epidermal growth factor receptor 2–negative advanced breast cancer.
“The Complexity of Loss Itself”: The Comics Form andFun Home’s Queer Reparative Temporality
Authors: McCullough Kate 
Published: June 2018

AbstractThis article assesses the queer world-making potentiality of the comics form as demonstrated in Alison Bechdel’s 2006 graphic memoir Fun Home. By deploying the temporal openings of the graphic form, Fun Home challenges the putative fixity of heteronormative family time and the temporality of kinship lines more broadly. Bechdel represents this queering of generation and kinship as a constituent part of the young Alison’s coming-of-age as a queer comics artist; this temporal reworking simultaneously makes possible a queer reparative web of affiliation. Building on Eve Kosofsky Sedgwick’s model of reparative reading, I demonstrate how Fun Home’s form produces a version of reparation that emerges from a shared artistry and embraces ambivalent affective responses to the past. Ultimately, Bechdel produces a queer feminist reparative reading that understands futurity’s potential as complex and grounded in both the pain and pleasure of the queer body.
The rate and predictors of patient satisfaction after total knee arthroplasty are influenced by the focus of the question
Authors: Clement N. D. , Bardgett M. , Weir D. , Holland J. , Gerrand C. , Deehan D. J. 
Published: June 2018

Aims The primary aim of this study was to assess the rate of patient satisfaction one year after total knee arthroplasty (TKA) according to the focus of the question asked. The secondary aims were to identify independent predictors of patient satisfaction according to the focus of the question. Patients and Methods A retrospective cohort of 2521 patients undergoing a primary unilateral TKA were identified from an established regional arthroplasty database. Patient demographics, comorbidities, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and 12-Item Short-Form Health Survey (SF-12) scores were collected preoperatively and one year postoperatively. Patient satisfaction was assessed using four questions, which focused on overall outcome, activity, work, and pain. Logistic regression analysis was used to identify independent preoperative predictors of increased stiffness when adjusting for confounding variables. Results Using patient satisfaction with the overall outcome (n = 2265, 89.8%) as the standard, there was no difference in the rate of satisfaction for pain relief (n = 2277, odds ratio (OR) 0.95, 95% confident intervals (CI) 0.79 to 1.14, p = 0.60), but patients were more likely to be dissatisfied with activities (79.3%, n = 2000/2521, OR 2.22, 95% CI 1.96 to 2.70, p < 0.001) and work (85.8%, n = 2163/2521, OR 1.47, 95% CI 1.23 to 1.75, p < 0.001). Logistic regression analysis identified different predictors of satisfaction for each of the focused satisfaction questions. Overall satisfaction was influenced by diabetes (p = 0.03), depression (p = 0.004), back pain (p < 0.001), and SF-12 physical (p = 0.008) and mental (p = 0.01) components. Satisfaction with activities was influenced by depression (p = 0.001), back pain (p < 0.001), WOMAC stiffness score (p = 0.03), and SF-12 physical (p < 0.001) and mental (p < 0.001) components. Satisfaction with work was influenced by depression (p = 0.007), back pain (p < 0.001), WOMAC function (p = 0.04) and stiffness (p = 0.05) scores, and SF-12 physical (p < 0.001) and mental (p < 0.001) components. Satisfaction with pain relief was influenced by diabetes (p < 0.001), back pain (p < 0.001), and SF-12 mental component (p = 0.04). Conclusion The focus of the satisfaction question significantly influences the rate and the predictors of patient satisfaction after TKA. Cite this article: Bone Joint J 2018;100-B:740–8.
Are inflatable play structures really safe for our children?
Authors: Corominas L. , Fernandez-Ansorena A. , Martinez-Cepas P. , Sanpera J. , Obieta A. 
Published: June 2018

Purpose The frequency of injuries sustained while playing on inflatable toys such as bouncy castles have rapidly increased. These supposedly safe structures are likely unsafe. The objective of this review was to investigate the risk that these attractions represent and the necessary measures to minimize risk of accidents. Methods We conducted a prospective study of 114 patients over a period of one year (2015 to 2016). Demographic data collected included: age, gender, anatomical location and side of involvement as well as supervision of the child whilst on the bouncy castle. The extracted data include mechanism of injury and risk factors, i.e. lack of supervision of the child, amounts of users jumping at the same time. Results The injuries were slightly more frequent in male than female children; 2:1 up to six years of age. From the age of ten to 14 years the ration evened to 1:1, the higher incidence in female children was between the ages of six to eight years. The most common injuries were to the humerus, followed by the distal radius. Only 28% of the parents said they were supervising while the child was jumping. Conclusion Injuries associated with inflatable bouncers have increased over time. The main risk factors: were lack of effective adult supervision and the shared use by an excessive number of participants of different ages and weights. These considerations lead to the conclusion that there is a necessity to enhance child health surveillance and to consider limiting bouncer usage to children over the age of six years, to prevent and control injuries and to minimize their consequences. Level of Evidence II - prospective study
Treatment of paediatric trigger finger: A systematic review and treatment algorithm
Authors: Womack M. E. , Ryan J. C. , Shillingford-Cole V. , Speicher S. , Hogue G. D. 
Published: June 2018

Purpose Paediatric trigger finger (PTF) is a rare condition as seen by the lack of studies published about paediatric populations. Due to this general lack of information, the steps to employ to correct this disorder, whether surgically or non-surgically, have not yet reached consensus status. The objective of this study is to review the published literature regarding treatment options for PTF in order to develop a proposed step-wise treatment algorithm for children presenting with trigger finger. Methods A systematic review of the literature was conducted on PubMed to locate English language studies reporting on treatment interventions of PTF. Data was collected on number of patients/fingers seen in the study, the category of the fingers involved, the number of patients/fingers undergoing each intervention and reported outcomes. Results Seven articles reporting on 118 trigger fingers were identified. In all, 64 fingers were treated non-surgically, with 57.8% (37/64) resolving. In all, 54 fingers were initially surgically treated, with 87% (47/54) resolving. In total, 34 fingers did not have resolution of symptoms following primary treatment, and 27 fingers received follow-up treatment, with 92.6% (25/27) resolving. Overall, 92.4% (109/118) of fingers achieved resolution of symptoms after all treatments were completed. Conclusion Limitations for this study included few prospective studies and small sample sizes. This is likely due to the rarity of PTF. This review of the literature indicated that a step-wise approach, including non-operative and surgical techniques, should be employed in the management of PTF. Level of Evidence III This work meets the requirements of the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).
Racionalidad comunicativa y democracia viva. Comentario crítico sobre "Libertad, Poder y Discurso" de Julio De Zan
Authors: Fornari Anibal 
Published: June 2018

Se intenta desarrollar el movimiento de pensamiento que conforma el libro Libertad, Poder y Discurso del filósofo santafesino Julio De Zan, dentro de la línea de la racional dad comunicativa y de la ética del discurso de Habermas y Apel, redefinidos a partir de la problemática político-cultural latinoamericana, del debate entre modernidad y post-modernidad y en orden a una democratización estructural de las sociedades. Se exponen los núcleos y pasajesargumentativos para un diálogo productivo en orden a la superación de las raíces de la "subjetividad egocéntrica" y su ideal ético-político plasmado en la cultura dominante y en las evidencias del actual proyecto de un "nuevo orden mundial".En una primera parte se delinean los momentos de la actual crisispolítico-cultural, con especial énfasis en la crisis de la racionalidad que no alcanza a ser superada, sino que es más bien profundizada, por las formas restaurativas, postmodernas y positivistas de discurso.En una segunda parte se ponen de relieve los momentos superadores elaborados desde dentro de la situación de crisis. Planteando una reconstrucción de Ja fuerza de la racionalidad dialectizable con Jos significados de las culturas efectivas; reelaborando comunicativamente el significado específico del poderpolítico y, finalmente, diseñando el valor ético de la democracia participativa como régimen político de la libertad positiva. En un próximo artículo se indicarán algunos puntos de discusión sobre la base del horizonte de reflexión abierto por este provocante libro.
Fantasy and its Suspension in an Age of Awkwardness: Timur Vermes’s Look Who’s Back
Authors: Yushinsky Troupin Orit 
Published: June 2018

Abstract
The paper examines the way Vermes’s bestseller and its cinematic adaptation, Look Who’s Back, are structured in analogy to Lacan’s notion of the fundamental fantasy, i. e., the framework within which subjects organize their desire in relation to the Other or to the Other’s desire. Employing mainly Adam Kotsko’s terms of awkwardness and sociopathy, I argue that the characters in the novel and the film and the implied and actual audiences constitute Hitler, the narrator and protagonist, as a fantasmatic awkward-sociopath big Other. Hitler is portrayed both as a ludicrous representation of an unsettling and awkward social order, that cannot implement clear and definite norms, and as a cynical sociopath who is incapable not only of overcoming this order but also of fixing it by making it ‘whole’ and consistent again. Discussing major differences between the novel and the film, I examine the ways audiences may fall and avoid falling into the trap of the novel’s and the film’s fantasy. This interpretation contributes simultaneously to the assessment of Hitler’s specific portrayal in Look Who’s Back and the critical exploration of his emblematic representation in our contemporary culture as well as its reasons and effects.
Postcolonializing Practical Theological Methodology as Cartography of Boundary Dynamics
Authors: Park Hee-Kyu Heidi 
Published: June 2018

AbstractThis paper conceptualizes a postcolonializing practical theological methodology that maps out the boundary dynamics of spectrality that often characterize the lived experiences on the margin of the empire. It draws from the mathematical understanding of Brownian motion that calculates the random movements of particles, as exposed by quantum mechanics, to construct an image for the postcolonializing practical theology. Then the random movement is explored through the concept of spectrality, which is engaged in dialogue with a 17th century Korean novel, Jangwha Hongryun Jeon, cultural theories and theologies.
Appraisal, Preaching and the Religious Other: The Rhetorical Appropriation of Interreligious Positions in Sermonic Discourse
Authors: Malmström Hans 
Published: June 2018

AbstractThis paper explores preachers’ deployment of Appraisal (affect, judgement, appreciation, and dialogic engagement) in preaching on interreligious themes. Adopting a comparative discourse analysis, the paper investigates two American sermons representing diametrically opposed theological responses to other religions, a pluralist sermon in the Unitarian Universalist tradition and an exclusivist sermon in the biblical-evangelical tradition. An analysis of the two preachers’ Appraisal choices reveals two distinct Appraisal profiles. A discussion is then offered demonstrating how Appraisal is conducive to the appropriation and conservation of a specific interreligious persona during preaching.
Interaction between doped C60 fullerenes and piperazine-2,3,5,6-tetraone: DFT simulation
Authors: Alver Özgür , Parlak Cemal , Ramasami Ponnadurai , Şenyel Mustafa 
Published: June 2018

Abstract
Piperazine and tetraone-related compounds are widely used in the drug industry. Heteroatom-doped fullerenes are studied as new types of sensor devices, and medical applications are studied as drug delivery vehicles. In this work, Si- or Al-doped C60 fullerenes and their interactions with piperazine-2,3,5,6-tetraone (ppto) molecule and some important structural or electronic properties were examined using the density functional theory (DFT). Results indicate that doped C60 fullerenes might be used to diagnose the presence of ppto as delivery vehicle and sensor because of their high adsorption energies and change of band gap energies.
Intercultural communication within a Chinese subsidiary of a Western MNC: Expatriate perspectives on language and communication issues
Authors: Wilczewski Michał , Søderberg Anne-Marie , Gut Arkadiusz 
Published: June 2018

AbstractThis study investigates Polish expatriates’ stories of encounters with local personnel in a Chinese subsidiary of a Western multinational company. A narrative analysis of the stories produced important insights into Polish-Chinese communication in an intra-subsidiary context. Low proficiency in the host language was a serious obstacle to expatriate socialization and a source of expatriates’ exclusion and social isolation in the workplace, which often led to stress, frustration, and negative attitudes toward collaboration with local personnel. Language-related issues prevented the expatriates from acquiring information from Chinese superiors, learning about problems within a team, and participating in decision-making. The findings of this case study relate to communication challenges in the Chinese subsidiary, expatriates’ accounts of how they overcame communication difficulties, and their reflections on what fostered and hampered intercultural communication.
Crystal structure of guanidinium tetrabutyl-ammonium 5-hydroxyisophthalate dihydrate, C25H50N4O7
Authors: Liu Yalin , Li Qiufang 
Published: June 2018

Abstract
C25H50N4O7, monoclinic, P21/c (no. 14), a = 14.7637(11) Å, b = 12.0608(9) Å, c = 16.7391(14) Å, β = 101.086(1)°, V = 2925.0(4), Z = 4, R
gt(F) = 0.0489, wR
ref(F
2) = 0.1076, T = 296(2) K.
Crystal structure of ethyl 4-amino-5-(5-methyl-1-(4-tolyl)-1H-1,2,3-triazole-4-carbonyl)-2-(phenylamino)thiophene-3-carboxylate, C24H23N5O3S
Authors: Geesi Mohammed H. , Mohamed Hanan A. , Abdel-Wahab Bakr F. , Hegazy Amany S. , Kariuki Benson M. , El-Hiti Gamal A. 
Published: June 2018

Abstract
C24H23N5O3S, triclinic, P1̅ (no. 2), a = 9.1704(9) Å, b = 10.1253(11) Å, c = 12.2182(14) Å, α = 83.686(10)°, β = 89.542(9)°, γ = 76.982(9)°, V = 1098.5(2) Å3, Z = 2, R
gt(F) = 0.0551, wR
ref(F
2) = 0.1510, T = 296(2) K.
Existence and Stability of Difference Equation in Imprecise Environment
Authors: Mondal Sankar Prasad , Khan Najeeb Alam , Vishwakarma Dileep , Saha Apu Kumar 
Published: June 2018

AbstractIn this paper, first order linear homogeneous difference equation is evaluated in fuzzy environment. Difference equations become more notable when it is studied in conjunction with fuzzy theory. Hence, here amelioration of these equations is demonstrated by three different tactics of incorporating fuzzy numbers.Subsequently, the existence and stability analysis of the attained solutions of fuzzy difference equations (FDEs) are then discussed under different cases of impreciseness. In addition, considering triangular and generalized triangular fuzzy numbers, numerical experiments are illustrated and efficient solutions are depicted, graphically and in tabular form.