bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partnership Communication Plan to Support the Implementation of Holistic-Integrative Early Childhood Education (PAUD HI).
Authors: Safitri Dhian Gowinda Luh 
Published: November 2024

The government has issued a policy requiring that Early Childhood Education Institutions must be conducted in a holistic-integrative manner to improve the quality of Early Childhood Education, provide a comprehensive, quality service, and involve all related education stakeholders. As a matter of fact, that the partnership between school, family, and community could enhance student's learning, accommodate the diverse needs of the student and bring an inclusive culture in education, it's essential for the teacher to develop communication partnership plan. This study was conducted in a systematic review with a qualitative approach. The communication values that can be implemented to develop an effective partnership are include understanding and respecting, openness, mutual trust, and commitment. The possible obstacles to implement this communication partnership plan components include a judgmental attitude when working with family and community, school as a hostile environment, the assumption that family and community are less able in the educational process, and lack of teacher partnership training.
The seed quality of Deutzia Thunb. in the conditions of the Bashkir Urals
Authors: Murzabulatova Fanuza Kavievna , Polyakova Natal'ya Viktorovna 
Published: November 2024

Representatives of the genus Deutzia are widely used in decorative gardening in European countries. In regions with a more severe climate, the plants are less viable. Probably for this reason, this crop is poorly studied and practically not used in landscaping in northern latitudes. However, a small group of species of the genus Deutzia has broad adaptive properties when grown in new climatic conditions. Therefore, at the moment there is a need to assess the quality of seeds of some types of action in the conditions of the Southern Urals. The aim of the work is to identify the characteristics of the quality of seeds of resistant species of the genus Deutzia for cultivation in the Southern Urals. The material for the study was the seeds of 3 species of deuterium cultivated in the South Ural Botanical Garden-Institute of the UFIC RAS and most adapted to the climate of the area of introduction: D. parviflora Bge., D. parviflora var. amurensis Rgl., D. glabrata Kom. The seasonal rhythm of plant development was studied according to the generally accepted method of phenological observations; winter hardiness was determined on a 7-point scale of the Main Botanical Garden of the Russian Academy of Sciences; seed weight was determined by weighing: the result was the average weight of 3 canopies of 1000 pieces; seed germination and germination energy were determined according to GOST. The seeds of the studied species of deuterium are approximately the same and average 0.03 g, but the seed weight of D. parviflora var. amurensis is slightly lower compared to the other two species. Laboratory and soil germination in D. parviflora has maximum parameters (about 67%), also in this species the maximum germination energy is noted (31%), the minimum values of this indicator are recorded in Deutzia glabrata (15%). The laboratory germination of seeds after 1 year of storage remains relatively high, but after 2 years of storage it decreases sharply, and after 3 years the seeds no longer germinate. Thus, the studied types of actions are promising for introduction into culture and wide application in landscaping of settlements of the Republic of Bashkortostan.
Conjugated Polymer Nanoparticles for Imaging, Cell Activity Regulation, and Therapy
Authors: Wang Yunxia , Feng Liheng , Wang Shu 
Published: November 2018

AbstractConjugated polymer nanoparticles, considered as a class of promising nanomaterials for biomedical application, are extensively employed in bioimaging, anti‐microorganism and antitumor, gene and drug delivery/release in the past decade. By virtue of unique photoelectric properties, such as strong light absorbing quality, high brightness, good photostability, tunable spectra property, and favorable compatibility, conjugated polymer nanoparticles attract increasing attention and are used in more emerging aspects in biological and biomedical fields. This review summarizes the recent (2014–2018) development of conjugated polymer nanoparticles, including design, synthesis, and biomedical applications. Especially, their abilities of bioimaging, cell activity regulation, anti‐microorganism and antitumor therapy are discussed in detail. Finally, the challenges and outlooks in the field are highlighted.
The Human In Vivo Biomolecule Corona onto PEGylated Liposomes: A Proof‐of‐Concept Clinical Study
Authors: Hadjidemetriou Marilena , McAdam Sarah , Garner Grace , Thackeray Chelsey , Knight David , Smith Duncan , Al‐Ahmady Zahraa , Mazza Mariarosa , Rogan Jane , Clamp Andrew , Kostarelos Kostas 
Published: November 2018

AbstractThe self‐assembled layered adsorption of proteins onto nanoparticle (NP) surfaces, once in contact with biological fluids, is termed the “protein corona” and it is gradually seen as a determinant factor for the overall biological behavior of NPs. Here, the previously unreported in vivo protein corona formed in human systemic circulation is described. The human‐derived protein corona formed onto PEGylated doxorubicin‐encapsulated liposomes (Caelyx) is thoroughly characterized following the recovery of liposomes from the blood circulation of ovarian carcinoma patients. In agreement with previous investigations in mice, the in vivo corona is found to be molecularly richer in comparison to its counterpart ex vivo corona. The intravenously infused liposomes are able to scavenge the blood pool and surface‐capture low‐molecular‐weight, low‐abundance plasma proteins that cannot be detected by conventional plasma proteomic analysis. This study describes the previously elusive or postulated formation of protein corona around nanoparticles in vivo in humans and illustrates that it can potentially be used as a novel tool to analyze the blood circulation proteome.
Room‐Temperature Ferromagnetic Insulating State in Cation‐Ordered Double‐Perovskite Sr2Fe1+xRe1−xO6Films
Authors: Sohn Changhee , Skoropata Elizabeth , Choi Yongseong , Gao Xiang , Rastogi Ankur , Huon Amanda , McGuire Michael A. , Nuckols Lauren , Zhang Yanwen , Freeland John W. , Haskel Daniel , Lee Ho Nyung 
Published: November 2018

AbstractFerromagnetic insulators (FMIs) are one of the most important components in developing dissipationless electronic and spintronic devices. However, FMIs are innately rare to find in nature as ferromagnetism generally accompanies metallicity. Here, novel room‐temperature FMI films that are epitaxially synthesized by deliberate control of the ratio between two B‐site cations in the double perovskite Sr2Fe1+xRe1‐xO6 (−0.2 ≤ x ≤ 0.2) are reported. In contrast to the known FM metallic phase in stoichiometric Sr2FeReO6, an FMI state with a high Curie temperature (Tc ≈ 400 K) and a large saturation magnetization (MS ≈ 1.8 µB f.u.−1) is found in highly cation‐ordered Fe‐rich phases. The stabilization of the FMI state is attributed to the formation of extra Fe3+Fe3+ and Fe3+Re6+ bonding states, which originate from the relatively excess Fe ions owing to the deficiency in Re ions. The emerging FMI state created by controlling cations in the oxide double perovskites opens the door to developing novel oxide quantum materials and spintronic devices.
Human–Machine Interfacing Enabled by Triboelectric Nanogenerators and Tribotronics
Authors: Ding Wenbo , Wang Aurelia C. , Wu Changsheng , Guo Hengyu , Wang Zhong Lin 
Published: November 2018

AbstractWith the advances of artificial intelligence (AI), autonomous robotics, virtual reality (VR) and Internet of things (IoT), an intelligent and ubiquitous human–machine interfacing (HMI) ecosystem has become a desire and attracted lots of interests. Triboelectric nanogenerators (TENG), as a natural and effective mechanical‐to‐electrical signal conversion technology, have been successfully utilized to realize many types of HMI, including smart keyboards, body motion sensors, the electronic skin, voice sensors, the triboelectrification‐induced electroluminescence, and the artificial muscle. Meanwhile, tribotronics, as the coupling field of TENG and semiconductors, has demonstrated the feasibility for tactile switch or sensing with the possibilities of high integration and large scale. The fundamental theory of TENG and tribotronics is revisited herein. In addition, the definition of HMI and, for the first time, the research progress of the TENG and tribotronics enabled HMI are systematically and thoroughly reviewed. Finally, the perspectives in this emerging field are also discussed.
The Charge Storage Mechanisms of 2D Cation‐Intercalated Manganese Oxide in Different Electrolytes
Authors: Zhang Qingnuan , Levi Mikhael D. , Dou Qingyun , Lu Yulan , Chai Yinguang , Lei Shulai , Ji Hengxing , Liu Bao , Bu Xudong , Ma Pengjun , Yan Xingbin 
Published: November 2018

Abstract2D ion‐intercalated metal oxides are emerging promising new electrodes for supercapacitors because of their unique layered structure as well as distinctive electronic properties. To facilitate their application, fundamental study of the charge storage mechanism is required. Herein, it is demonstrated that the application of in situ Raman spectroscopy and electrochemical quartz crystal microbalance with dissipation monitoring (EQCM‐D), provides a sufficient basis to elucidate the charge storage mechanism in a typical 2D cation‐intercalated manganese oxide (Na0.55Mn2O4·1.5H2O, abbreviated as NMO) in neutral and alkaline aqueous electrolytes. The results reveal that in neutral Na2SO4 electrolytes, NMO mainly displays a surface‐controlled pseudocapacitive behavior in the low potential region (0–0.8 V), but when the potential is higher than 0.8 V, an intercalation pseudocapacitive behavior becomes dominant. By contrast, NMO shows a battery‐like behavior associated with OH− ions in alkaline NaOH electrolyte. This study verifies that the charge storage mechanism of NMO strongly depends on the type of electrolyte, and even in the same electrolyte, different charging behaviors are revealed in different potential ranges which should be carefully taken into account when optimizing the use of the electrode materials in practical energy‐storage devices.
Long‐term improvement in cardiac magnetic resonance in β‐thalassemia major patients treated with deferasirox extends to patients with abnormal baseline cardiac function
Authors: Casale Maddalena , Filosa Aldo , Ragozzino Alfonso , Amendola Giovanni , Roberti Domenico , Tartaglione Immacolata , De Michele Elisa , Cozzolino Domenico , Rispoli Giuliana , Palmieri Francesco , Pugliese Umberto , Scianguetta Saverio , Signoriello Giuseppe , Musallam Khaled M. , Perrotta Silverio 
Published: November 2018

AbstractThe management of iron overload in thalassemia has changed dramatically since the implementation of magnetic resonance imaging, which allows detection of preclinical iron overload and prevention of clinical complications. This study evaluated the effect of deferasirox (DFX), the newest once‐daily oral chelator, on cardiac function, iron overload and cardiovascular events over a longer follow up in a “real world” setting. Longitudinal changes in cardiac magnetic resonance T2*, cardiac function parameters and cardiovascular clinical events were assessed in a cohort of 98 TM patients exposed to DFX for a mean of 6.9 years (range 1.8‐11.6 years). No cardiac death or incident heart failure occurred. Cardiac T2* significantly increased (+2.6 ± 11.9 msec; P = 0.035) in the whole population, with a significantly greater increase (+11.6 ± 15.5 msec, P = 0.019) in patients with cardiac iron overload (T2* <20 ms). A significant improvement in left‐ventricular ejection fraction (LVEF) (from 50.6 ± 6 to 60.2 ± 5; P = 0.001) was observed in 11 (84.6%) out of 13 patients who normalized cardiac function (LVEF >56%). Arrhythmias were the most frequent cardiac adverse event noted but none led to DFX discontinuation. Our data indicate that DFX is effective in maintaining cardiac iron level in the normal range and in improving cardiac iron overload. No heart failure or cardiac death was reported over this longer observation up to 12 years. For the first time, a DFX‐induced improvement in LVEF was observed in a subgroup of patients with abnormal cardiac function at baseline, a preliminary observation which deserves further evaluation.
Dietary ursolic acid improves health span and life span in male Drosophila melanogaster
Authors: Staats Stefanie , Wagner Anika E. , Lüersen Kai , Künstner Axel , Meyer Timo , Kahns Anna K. , Derer Stefanie , Graspeuntner Simon , Rupp Jan , Busch Hauke , Sina Christian , Ipharraguerre Ignacio R. , Rimbach Gerald 
Published: November 2018

AbstractThe health and life span of Drosophila melanogaster are partly determined by intestinal barrier integrity, metabolic rate as well as stress response and the expression of longevity‐associated genes, depending on genetic and dietary factors. Ursolic acid (UA) is a naturally occurring triterpenoid exhibiting potential antimicrobial, anti‐inflammatory, and antiobesity activity and counteracting age‐related deficits in muscle strength. In this study, UA was dietarily administered to w1118 D. melanogaster which significantly elongated the health and life span of males. Spargel (srl) is the Drosophila orthologue of mammalian peroxisome proliferator‐activated receptor‐gamma coactivator 1 α(PGC1α), an important regulator of energy homeostasis and mitochondrial function. Our results indicate that the health‐promoting effect of UA, demonstrated by a significant increase in climbing activity, occurs via an upregulation of srl expression leading to a metabolic shift in the fly without reducing fecundity or gut integrity. Moreover, UA affected the flies' microbiota in a manner that contributed to life span extension. Srl expression and microbiota both seem to be affected by UA, as we determined by using srl‐mutant and axenic flies. © 2018 BioFactors, 45(2):169–186, 2019
Autoantibodies in HIV‐infected patients: Cross site‐specific hydrolysis of H1 histone and myelin basic protein
Authors: Baranova Svetlana V. , Dmitrienok Pavel S. , Buneva Valentina N. , Nevinsky Georgy A. 
Published: November 2018

AbstractHistones act as damage‐associated molecules, while anti‐DNA antibodies are directed against histone‐DNA nucleosomal complexes. Myelin basic protein (MBP) plays an important role in the pathogenesis of multiple sclerosis. Autoantibodies (Abs) with enzymatic activities are the distinctive feature of some autoimmune and viral diseases. Abzymes with proteolytic activity against different proteins specifically hydrolyze only these specific proteins. Using chromatography of IgGs on columns with immobilized H1 histone and then by chromatography of the fraction having an affinity for the histone (eluted upon loading) on MBP Sepharose, the anti‐MBP antibodies were obtained. Anti‐H1 antibodies were obtained using these columns in reverse order. IgGs against H1 and MBP effectively hydrolyze both H1 histone and MBP but no other control proteins. Using the MALDI mass spectrometry, the cleavage sites of H1 histone and MBP by abzymes against these proteins are found. The hydrolysis of MBP by anti‐MBP IgGs occurs at four clusters (22 sites of the hydrolysis) locating at four known antigenic determinants of MBP. Anti‐H1 Abs hydrolyze MBP only at one cluster (11 sites of the hydrolysis); this cluster is only partially overlapped with one of the four MBP clusters. Anti‐H1 antibodies hydrolyze H1 at five sites of one cluster of the protein when anti‐MBP IgGs cleavage this histone at two clusters containing 17 sites of the cleavage. Anti‐H1 and anti‐MBP abzymes are the first examples of Abs possessing not only with cross‐complexing but also with catalytic cross‐reactivity. The existence of cross‐reactivity of abzymes against histones and MBP represent great danger to humans. © 2018 BioFactors, 45(2):211–222, 2019
Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival
Authors: Huang Chao‐Yuan , Hsueh Yu‐Mei , Chen Lih‐Chyang , Cheng Wei‐Chung , Yu Chia‐Cheng , Chen Wei‐Jen , Lu Te‐Ling , Lan Kuo‐Jin , Lee Cheng‐Hsueh , Huang Shu‐Pin , Bao Bo‐Ying 
Published: November 2018

AbstractAccumulating evidence suggests the roles of glutamate metabotropic receptors (GRMs) in cancer, in addition to synaptic signalling. The present study assessed the associations of genetic variants in eight GRM genes with regard to risk and overall survival (OS) in 780 renal cell carcinoma (RCC) patients and controls. After adjustment for known risk factors, GRM5 rs7102764 T was associated with an increased risk of RCC (P = 0.006). Additional analysis has provided evidence that rs7102764 T was correlated with a higher expression of GRM5, which is consistently found to be upregulated in tumours, compared to normal tissues. Furthermore, the GRM3 rs701332 C, GRM4 rs2499707 T, and GRM4 rs4713742 T alleles were significantly associated with a poorer OS (P ≤ 0.030). The three loci were also observed to have strong cumulative effects on OS. Additional analysis has revealed a significant genotype‐expression correlation of rs2499707 T with increased GRM4 expression, which in turn leads to poorer OS in patients with RCC. GRMs might be involved in RCC development and progression, and genetic variants in GRMs might be promising biomarkers.
Estimating effectiveness of school‐based counselling: Using data from controlled trials to predict improvement over non‐intervention change
Authors: Cooper Mick , Fugard Andrew J.B. , Pybis Jo , McArthur Katherine , Pearce Peter 
Published: November 2018

AbstractBackgroundThere is a growing body of data to show that participation in school‐based counselling is associated with significant reductions in psychological distress. However, this cannot be taken as evidence that school‐based counselling is effective, as improvements may have happened without the intervention.AimsThe purpose of this study was to develop a method of estimating the amount of ‘natural’ change that might be expected in young people who would attend school‐based counselling, such that the effects of the intervention over and above this amount could be identified.MethodYoung Person's CORE (YP‐CORE) scores from 74 participants allocated to waiting list control conditions in four pilot trials of school‐based counselling in the UK were re‐analysed using regression models, and a formula was found for estimating the outcomes for young people were they not to receive counselling. This was termed their Estimated Non‐intervention Outcome (ENO), and could then be compared against the young person's Actual Outcome (AO), to give an estimated intervention effect (EIE).ResultsThe formula for the ENO was 4.17 + 0.64 × baseline score. Using this, we calculated a mean EIE for 256 young people in a cohort evaluation study of school‐based counselling, which showed that the counselling was associated with large and significantly greater change than would be expected without the intervention (Cohen's d = 0.91).DiscussionThe method presented in this paper is a simple means for improving the accuracy of estimations of treatment effectiveness, helping to adjust for changes due to spontaneous recovery and other non‐treatment effects.
Using personality traits and attachment styles to predict people's preference of psychotherapeutic orientation
Authors: Petronzi Gregory J. , Masciale James N. 
Published: November 2018

AbstractAimThis study examined whether people's personality traits and attachment styles would predict their preference for one of three common psychotherapies (psychodynamic, person‐centred and cognitive‐behavioural therapy).MethodAn online survey was administered to participants (n = 209) for remuneration. Personality traits were measured using the HEXACO‐60; attachment was measured using the Relation‐ships Questionnaire; preference for psychotherapeutic orientation was assessed using the Preferences for Psychotherapy Approaches Scale.ResultsRegression analyses indicated that various personality traits and attachment styles predict preference of therapeutic orientation. Specifically, the data indicated that openness and secure attachment significantly predicted preference of psychodynamic psychotherapy. No personality traits or attachment styles significantly predicted person‐centred preference. Lastly, previous study of psychology and fearful attachment significantly predicted preference of cognitive‐behavioural psychotherapy.ConclusionThis study's findings provide supporting evidence for the claim that people's personality traits and attachment styles are predictive of their preferences for various psychotherapies. Implications for further research are discussed.
‘An outfield at a cricket game’: Integrating support provisions in counsellor education
Authors: Georgiadou Lorena , Willis Alette , Canavan Siobhan 
Published: November 2018

AbstractBackgroundThe demanding nature of counsellor education necessitates support provisions for trainees which promote learning and development. While clinical and academic supervision, as well as personal therapy, can be important sources of support and learning, they are targeted at specific aspects of the trainee experience.AimIn this study, we examine the need for additional provisions that are integrative, phronetic and, although related to core training, separate from it, allowing trainees to bring together theory, personal experience and practice in a safe space. We present a study investigating student and staff experiences of using a system of ‘Personal Tutorials’ designed to provide phronetic and integrative support, which is in operation at our institution. Our study sought to explore the ways in which students made use of this system and what helped or hindered them in using it integratively.MethodologyFocus groups were conducted with students, core staff and Personal Tutors involved in this provision. Data were analysed following a reflective team‐based approach (Siltanen, Willis & Scobie, 2008).FindingsOverall, trainees appreciated having a dedicated space to explore their learning with a nonassessing tutor and used this provision in a number of ways that advanced their personal and professional development.ImplicationsAn external Personal Tutor seems to be providing trainees with an additional phronetic source of support that balances individual and group learning and advances the overall training experience.
SCAI 2018 Think Tank Proceedings: “What skillsets are required of vascular interventional cardiologists in evaluating and managing critical limb ischemia (CLI)? What role should SCAI play in supporting interventional cardiologists in their CLI practices, individually and collectively?”
Authors: Hawkins Beau M. , Aronow Herbert D. , Parikh Sahil A. , Rosenfield Kenneth , Naidu Srihari S. ,   And the members of the SCAI 2018 Think Tank Consortium: Ellie Boutin, Fennel Brian , Fontenot Kristin , Nicolosi Mary , Tieche Christopher 
Published: November 2018

AbstractThe aim of this article is to discuss the poor outcomes associated with critical limb ischemia (CLI) and the required knowledge needed for optimal care. There is an opportunity for the Society for Cardiovascular Angiography and Interventions (SCAI) to assist interventional cardiologists in enhancing CLI care through creation of training standards and development of educational content.