bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boosting Dendrite‐Free Zinc Anode with Strongly Polar Functional Group Terminated Hydrogel Electrolyte for High‐Safe Aqueous Zinc‐Ion Batteries
Authors: Li Junyuan , Zhang Heng , Liu Ziming , Du Hao , Wan Hongxin , Li Xiangcai , Yang Jun , Yan Chao 
Published: November 2024

AbstractAqueous zinc‐ion batteries (AZIBs) have become a promising energy storage device due to their low cost and high security. However, the severe dendrite growth and side reactions on metallic zinc (Zn) anode hamper their commercial implementation. Herein, a strongly electronegative trifluoroborate anion (─BF3−) functionalized polyacrylamide hydrogel (PAME) is well‐designed and constructed as the quasi‐solid‐state electrolyte to overcome these obstacles. The PAME chain segments terminated with strongly polar functional groups promote the conversion of water molecules from free water to bound water through the enhanced hydrogen bonding interaction to alleviate the side reactions. Furthermore, the PAME electrolyte featured with hierarchically porous structure and enhanced electrostatic interaction among the ─BF3− groups, and Zn2+ ions homogenizes the high‐flux Zn ion transport and induce the uniform deposition to restrain dendrite growth. Consequently, the assembled Zn‖PAME‖Zn batteries deliver remarkable cycling stability over 1800 h at 1 mA cm−2 and 900 h at 15 mA cm−2. Additionally, the constructed Zn‖PAME‖MnO2 full cells achieve a reversible capacity of 202 mAh g−1 at 2.0 A g−1 with a capacity retention rate of 91.4% over 500 cycles. This work sheds light on constructing the strongly polar hydrogel electrolyte to boost free‐dendrite Zn anodes for long‐lifespan AZIBs.
An Ultrafast and Ultralow‐Temperature 3D‐Printed All‐Organic Proton Pseudocapacitor
Authors: Zhang Miaoran , Yao Tengyu , Xu Tiezhu , Zhou Xinji , Chen Duo , Shen Laifa 
Published: November 2024

AbstractA critical challenge for pseudocapacitors applications is the rapid capacitance fading under extreme environments, which originates from sluggish diffusion kinetics of inorganic materials and tortuous ionic channels in conventional bulk electrodes. Herein, a novel 3D‐printed all‐organic proton pseudocapacitor (composed of 2,6‐diaminoanthraquinone (DQ)‐based anode and polyaniline‐based cathode) with chemical and structural stability is developed, which exhibits an extraordinary rate performance and cycle stability under ultralow temperature. The DQ molecules are anchored on reduced graphene oxide, which enhances the electronic conductivity and structural stability. Theoretical calculation and spectroscopic characterization reveal that the two‐electron transfer process involves quinone/hydroquinone transition. Exploiting the synergy of fast reaction kinetics of organic and the efficient ion diffusion paths of the 3D architecture, the 3D‐printed anode achieves an impressive areal capacitance of 10.14 F cm−2 at high mass loading (28.73 mg cm−2). The 3D‐printed all‐organic proton pseudocapacitor shows stable cycling performance at −80 °C and releases a high energy density of 0.76 mWh cm−2 at −60 °C. This work is instructive for the development of competitive ultra‐low temperature energy storage devices via integrating organic materials and 3D architectural electrode designs.
Internal Encapsulation Enables Efficient and Stable Perovskite Solar Cells
Authors: Li Wang , Bao Xiaozhi , Zhu Annan , Gu Hao , Mao Yulin , Wang Bingzhe , Wang Gang , Guo Jia , Li Ying , Xing Guichuan 
Published: November 2024

AbstractPerovskite solar cells (PSCs) have made significant strides in efficiency, but their long‐term stability remains a challenge. While external encapsulation mitigates extrinsic degradation and lead leakage, it does not fully address performance decline due to ion migration within the perovskite devices. Therefore, an internal encapsulation layer that can selectively transport charge carriers and suppress ion migration across the interface is of great significance for achieving long‐term stability in these devices. Here, polytetrafluoroethylene (PTFE) can serve as an effective internal encapsulation layer between the perovskite film and the electron transport layer in the inverted PSCs is demonstrated. The PTFE layer can selectively transport electrons and suppress ion diffusion, resulting in a higher power conversion efficiency (PCE) of 25.49% compared to 24.74% of the control devices and much better long‐term stability. Even after 1500 h of air exposure, the internal encapsulated perovskite devices can maintain 92.6% of their original PCE, outperforming the control devices at 80.4%. This approach offers a novel solution for addressing ion migration‐induced instability in perovskite devices.
A Self‐powered Tennis Training System Based on Micro‐Nano Structured Sensing Yarn Arrays
Authors: Chen Qian , Xu Duo , Yan Yan , Qu Zhan , Zhao Haoyue , Li Xinyu , Cao Yuying , Lang Chenhong , Akram Wasim , Sun Zhe , Niu Li , Fang Jian 
Published: November 2024

AbstractWearable sensing devices can reliably track players' mobility, revolutionizing sports training. However, current sensing electronics face challenges due to their complex structures, battery dependence, and unreliable sensing signals. Here, a tennis training system is demonstrated using machine learning based on elastic self‐powered sensing yarns. By employing a simple and effective strategy, piezoelectric nanofibers and triboelectric materials are integrated into a single yarn, enabling the simultaneous translation of both triboelectric and piezoelectric signals. Additionally, these yarns exhibit outstanding processability, allowing them to be machine‐knitted into self‐powered sensing fabrics. Due to their great sensitivity, these sensing yarns and fabrics may detect human movement with great precision. Machine learning algorithms can classify and interpret these signals to recognize various human motions. The developed tennis training system aims to maximize its benefits and provide comprehensive training for both players and coaches. This work enhances the applicability of self‐powered sensing systems in smart sports monitoring and training, advancing the field of intelligent sports training.
Devouring Atherosclerotic Plaques: The Engineered Nanorobot Rousing Macrophage Efferocytosis by a Two‐Pronged Strategy
Authors: Zheng Jinrong , Li Yuanyuan , Ge Xiaofeng , Zhang Guoming , Wang Yan , Nawsherwan  , Yu Shaojun , Dai Cuilian , Sang Mangmang 
Published: November 2024

AbstractInvestigating the potential of macrophage efferocytosis has led to a growing interest in exploiting macrophage in immunotherapy. Macrophage‐specific nano‐medicines are currently being developed to stimulate the phagocytic clearance of apoptotic debris in atherosclerosis; however, these unnatural nanoparticles exhibit poor biocompatibility and limited efferocytosis activation ability. Here a pro‐efferocytosis biomimetic nanorobot UM‐EVLipo is developed based on nano‐motor and extracellular vesicles (EVs) hybridized with plaque double‐targeted liposomes. An elegant procedure with only 4 steps is integrated to prepare and purify these hybrid nanovesicles. It is first demonstrated that the EVs derived from bone marrow macrophages stimulated with IL‐4 can promote the transformation of M0 and M1 macrophages into M2, an efferocytosis phenotype. Furthermore, the EVs hybridized with SHP‐1 siRNA‐liposomes blocked the “don't eat me” signal from apoptotic debris by intervening CD47‐SIRPα‐SHP‐1 axis. This two‐pronged strategy of resetting phenotype and blocking checkpoints furthest activates macrophage efferocytosis. Importantly, the urease motor increased the swimming speed of nanovesicles in the blood by 12.4 times, making it easier for them to penetrate the endothelial barrier. The UM‐EVLipo accumulated within the atherosclerotic plaque, reactivate lesioned efferocytosis and reduce the plaque area in the carotid and coronary, which demonstrates the potential of a two‐pronged strategy to prevent atherosclerotic cardiovascular disease.
Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer‐Specific Release of CK2.1 and the “Exercise Hormone” Lac‐Phe for Enhanced Osteochondral Regeneration
Authors: Liu Po‐Lin , He Shu‐Hang , Shen Zhi‐Han , Li Xu‐Ran , Deng Qing‐Song , Wei Zhan‐Ying , Zhang Chang‐Ru , Dou Xiao‐Qiu , Zhu Tong‐He , Dawes Helen , Lu Jian , Guo Shang‐Chun , Tao Shi‐Cong 
Published: November 2024

AbstractRepairing osteochondral defects necessitates the intricate reestablishment of the microenvironment. The cartilage layer consists of a porous gelatin methacryloyl hydrogel (PGelMA) covalently crosslinked with the chondroinductive peptide CK2.1 via a “linker” acrylate‐PEG‐N‐hydroxysuccinimide (AC‐PEG‐NHS). This layer is optimized for remodeling the senescent microenvironment in the cartilage region, thereby establishing a regenerative microenvironment that supports chondrogenesis. For the bone layer, silk fibroin methacryloyl (SilMA) is coated onto a three dimensional (3D)‐printed 45S5 bioactive glass scaffold (BG scaffold). The “exercise hormone” N‐lactoyl‐phenylalanine (Lac‐Phe) is loaded onto the SilMA, endowing it with diversified functions to regulate the osteogenic microenvironment. Systematic analysis in vitro reveals that PGelMA‐CK2.1 shifts the microenvironment from a pro‐inflammatory into an anti‐inflammatory condition, and alleviates cellular senescence, thus modifying the cartilage microenvironment to improve the recruitment, proliferation and chondral differentiation of bone marrow mesenchymal stem cells (BMSCs). The scaffold bone layer enhances microvascular endothelial cell proliferation, migration, and angiogenic activities, which, couple with increased BMSC recruitment and regulatory mechanisms directing BMSC differentiation, favor a shift in the “osteogenesis–adipogenesis” balance toward enhanced osteogenesis. In vivo, it is found that this biphasic biomimetic scaffold favors simultaneous dual tissue regeneration. This approach facilitates the development of bioactive regenerative scaffolds and holds great potential for clinical application.
Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor‐Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug‐Resistant Tumors
Authors: Bi Tao , Zhao Qixin , Wang Ting , Huang Rui , Liu Bangguo , Liu Xinyue , Wang Yihuan , Sun Qin , Yang Yingcheng , Liu Zengjin 
Published: November 2024

AbstractBreast cancer is a malignant tumor that threatens the life and health of women worldwide. As the first‐line chemotherapy drug for breast cancer, doxorubicin (DOX) can inhibit the synthesis of RNA and DNA, and it exhibits strong inhibitory activity against breast cancer. However, drug‐induced systemic toxicity and drug resistance can occur with DOX treatment. In this work, TSPO protein is identified as a promising target for overcoming drug resistance and we designed a novel BT‐DOX/PDP conjugate to solve these problems in drug chemotherapy. It is found that BT‐DOX/PDP can effectively downregulate TSPO1 protein and sensitize MCF‐7/Adr to DOX. Furthermore, due to its positive charge, BT‐DOX/PDP is readily loaded into puerarin (PUE), the resulting BT‐DOX/PDP@PUE exhibited minimal systemic toxicity but enhanced antitumor activity in animal models, as compared with BT‐DOX/PDP. This study demonstrates the advantages of combined chemotherapy and photodynamic therapy in overcoming drug resistance, which may be applied in the design of other photodynamic therapy‐based conjugates to enhance antitumor therapy.
Synthesis of SrZnOSe Crystals with Low Phonon Energy for Enhancing Near‐Infrared Mechanoluminescence
Authors: Wang Yanze , Ren Biyun , Zheng Weilin , Peng Dengfeng , Wang Feng 
Published: November 2024

AbstractNear‐infrared (NIR) light is promising for bioimaging and information technology due to its high penetration ability and resistance to interference with environmental radiation. Here, a new class of lanthanide‐doped SrZnOSe crystals are developed for the self‐sustainable generation of NIR emissions under mechanical excitation. It is shown that the SrZnOSe crystals render ≈5‐fold stronger NIR emissions than the well‐established CaZnOS due to the low phonon energies of the selenide host, as confirmed by Raman spectroscopy. The potential utility of the crystals is demonstrated by integration with a mouthguard, which can generate bright NIR emissions by bite force to transmit encrypted optical signals through thick tissues (up to 8 mm) in ambient environments. The findings provide a powerful addition to the toolbox of self‐recovery mechanoluminescent materials and open new possibilities for applied research.
Long‐Range Proton Channels Constructed via Hierarchical Peptide Self‐Assembly
Authors: Censor Semion , Martin Jorge Vega , Silberbush Ohad , Reddy Samala Murali Mohan , Zalk Ran , Friedlander Lonia , Trabada Daniel G. , Mendieta Jesús , Le Saux Guillaume , Moreno Jesús Ignacio Mendieta , Zotti Linda Angela , Mateo José Ortega , Ashkenasy Nurit 
Published: November 2024

AbstractThe quest to understand and mimic proton translocation mechanisms in natural channels has driven the development of peptide‐based artificial channels facilitating efficient proton transport across nanometric membranes. It is demonstrated here that hierarchical peptide self‐assembly can form micrometers‐long proton nanochannels. The fourfold symmetrical peptide design leverages intermolecular aromatic interactions to align self‐assembled cyclic peptide nanotubes, creating hydrophilic nanochannels between them. Titratable amino acid sidechains are positioned adjacent to each other within the channels, enabling the formation of hydrogen‐bonded chains upon hydration, and facilitating efficient proton transport. Moreover, these chains are enriched with protons and water molecules by interacting with immobile counter ions introduced into the channels, increasing proton flow density and rate. This system maintains proton transfer rates closely resembling those in natural protein channels over micrometer distances. The functional behavior of these inherently recyclable and biocompatible systems opens the door for their exploitation in diverse applications in energy storage and conversion, biomedicine, and bioelectronics.
Greatly Enhanced Oxygen Reduction Reaction in Anion Exchange Membrane Fuel Cell and Zn‐Air Battery via Hole Inner Edge Reconstruction of 2D Pd Nanomesh
Authors: Tian Jiakang , Song Yanhui , Hao Xiaodong , Wang Xudong , Shen Yongqing , Liu Peizhi , Wei Zebin , Liao Ting , Jiang Lei , Guo Junjie , Xu Bingshe , Sun Ziqi 
Published: November 2024

AbstractPlatinum group metals (PGM) have yet to be the most active catalysts in various sustainable energy reactions. Their high cost, however, has made maximizing the activity and minimizing the dosage become an urgent priority for the practical applications of emerging technologies. Herein, a novel 2D Pd nanomesh structure possessing hole inner reconstructed edges (HIER) with exposed high energy facets and overstretched lattice parameters is fabricated through a facile room‐temperature reduction method at gram‐scale yields. The HIER enhances the catalytic performance of Pd in electrochemical oxygen reduction reaction (ORR), achieving superior mass activity (MA) of 2.672 A mgPd−1, which is 27.8 fold and 23.6 fold higher, respectively, than those of the commercial Pt/C (0.096 A mgPt−1) and Pd/C (0.113 A mgPd−1) at 0.9 VRHE. Most significantly, in H2‐air anion exchange membrane fuel cell (AEMFC) and Zn‐air battery (ZAB) applications, this unique Pd catalyst delivers a much‐outperformed peak power density of 0.86 and 0.22 W cm−2, respectively, compared with 0.54 and 0.13 W cm−2 of the commercial Pt/C catalyst, indicating a novel pathway in electrocatalyst designs through HIER engineering.
Bidentate NHC‐Containing Ligands for Copper Catalysed Synthesis of Functionalised Diaryl Ethers
Authors: Richards Ethan M. , Casarrubios Luis , D'Oyley Jarryl M. , Rzepa Henry S. , White Andrew J. P. , Goldberg Kristin , Goldberg Frederick W. , Bull James A. , Díez‐González Silvia 
Published: November 2024

AbstractDiaryl and heteroaryl ethers are important and common motifs in drug discovery and agrochemicals. Here we present a catalytic system for the copper catalysed arylation of phenols with aryl halides. Bidentate N‐heterocyclic carbene ligands provide a well‐defined catalytic system that enable low loading of copper in effective coupling reactions (0.5 mol% Cu or lower). The reaction scope of aryl iodides and aryl bromides is developed, that is tolerant of functional groups and a library of biaryl ethers with lead‐like properties is prepared. The presence of excess ligand (in a 1:3 ratio) is shown to be optimal to prevent catalyst degradation, presumably by avoiding decomplexation of the ligand. This is also supported by the catalytic results obtained with pre‐formed copper complexes. The kinetics of the reaction are examined and shown to be first order in copper, supportive of a well‐defined catalyst species, first order in phenol and aryl iodide, and zero order in base under the developed conditions. Computational studies performed using Minnesota MN15‐L parametrisation method support an oxidative addition‐reductive elimination sequence with both steps having similar enegies and the reductive elimination occurring through an intimate ion pair intermediate.
Thermogenic Adipocytes Promote M2 Macrophage Polarization through CNNM4‐Mediated Mg Secretion
Authors: Zhang Anke , Jiang Junkun , Zhang Chuan , Xu Houshi , Yu Wenjing , Zhang Zhen‐Ning , Yuan Ling , Lu Zhangming , Deng Yuqing , Fan Haonan , Fang Chaoyou , Wang Xiaoyu , Shao Anwen , Chen Sheng , Li Huaming , Ni Jiahua , Wang Wenhui , Zhang Xiaonong , Zhang Jianmin , Luan Bing 
Published: November 2024

AbstractM2 macrophages promote adipose tissue thermogenesis which dissipates energy in the form of heat to combat obesity. However, the regulation of M2 macrophages by thermogenic adipocytes is unclear. Here, it is identified magnesium (Mg) as a thermogenic adipocyte‐secreted factor to promote M2 macrophage polarization. Mg transporter Cyclin and CBS domain divalent metal cation transport mediator 4 (CNNM4) induced by ADRB3‐PKA‐CREB signaling in thermogenic adipocytes during cold exposure mediates Mg efflux and Mg in turn binds to the DFG motif in mTOR to facilitate mTORC2 activation and M2 polarization in macrophages. In obesity, downregulation of CNNM4 expression inhibits Mg secretion from thermogenic adipocytes, which leads to decreased M2 macrophage polarization and thermogenesis. As a result, CNNM4 overexpression in adipocytes or Mg supplementation in adipose tissue ameliorates obesity by promoting thermogenesis. Importantly, an Mg wire implantation (AMI) approach is introduced to achieve adipose tissue‐specific long‐term Mg supplement. AMI promotes M2 macrophage polarization and thermogenesis and ameliorates obesity in mice. Taken together, a reciprocal regulation of thermogenic adipocytes and M2 macrophages important for thermogenesis is identified, and AMI is offered as a promising strategy against obesity.
NSUN5 Facilitates Hepatocellular Carcinoma Progression by Increasing SMAD3 Expression
Authors: Han Hexu , zhang Chengcheng , Shi Wenbo , Wang Jiawei , Zhao Wenhui , Du Yanping , Zhao Zhibin , Wang Yifan , Lin Maosong , Qin Lei , Zhao Xiaoxue , Yin Qianqian , Liu Yiyi , Wang Zhongqi , Zhang Jing , You Xiaomin , Zhou Guoxiong , Wu Honghui , Ye Jun , He Xianzhong , Tian Weizhong , Yu Hong , Yuan Yin , Wang Qiang 
Published: November 2024

AbstractHepatocellular carcinoma (HCC) is characterized by frequent intrahepatic and distant metastases, resulting in a poor prognosis for patients. Epithelial–mesenchymal transition (EMT) plays a pivotal role in this process. However, the expression of NOP2/Sun RNA methyltransferase 5 (NSUN5) in HCC and its role in mediating EMT remain poorly understood. In this study, clinicopathological analyses are conducted across multiple independent HCC cohorts and induced tumor formation in Nsun5‐knockout mice. The findings reveal an upregulation of NSUN5 expression in tumor tissues; conversely, the absence of Nsun5 hinders the malignant progression of HCC, indicating that NSUN5 may serve as a significant oncogene in HCC. Furthermore, elevated levels of NSUN5 enhance EMT processes within HCC cells. NSUN5‐knockout cells exhibit reduced invasion and migration capabilities under both in vivo and in vitro conditions, while overexpression of NSUN5 yields opposing effects. Mechanistically, high levels of NSUN5 promote the enrichment of trimethylated histone H3 at lysine 4 (H3K4me3) at the promoter region of SMAD3 through recruitment of the WDR5, thereby facilitating HCC metastasis via SMAD3‐mediated EMT pathways. Collectively, this study identifies NSUN5 as a novel driver of metastasis in HCC and provides a theoretical foundation for potential therapeutic strategies against this malignancy.
Recent Development of Fibrous Hydrogels: Properties, Applications and Perspectives
Authors: Luo Wen , Ren Liujiao , Hu Bin , Zhang Huali , Yang Zhe , Jin Lin , Zhang Di 
Published: November 2024

AbstractFibrous hydrogels (FGs), characterized by a 3D network structure made from prefabricated fibers, fibrils and polymeric materials, have emerged as significant materials in numerous fields. However, the challenge of balancing mechanical properties and functions hinders their further development. This article reviews the main advantages of FGs, including enhanced mechanical properties, high conductivity, high antimicrobial and anti‐inflammatory properties, stimulus responsiveness, and an extracellular matrix (ECM)‐like structure. It also discusses the influence of assembly methods, such as fiber cross‐linking, interfacial treatments of fibers with hydrogel matrices, and supramolecular assembly, on the diverse functionalities of FGs. Furthermore, the mechanisms for improving the performance of the above five aspects are discussed, such as creating ion carrier channels for conductivity, in situ gelation of drugs to enhance antibacterial and anti‐inflammatory properties, and entanglement and hydrophobic interactions between fibers, resulting in ECM‐like structured FGs. In addition, this review addresses the application of FGs in sensors, dressings, and tissue scaffolds based on the synergistic effects of optimizing the performance. Finally, challenges and future applications of FGs are discussed, providing a theoretical foundation and new insights for the design and application of cutting‐edge FGs.
Intrinsic PD‐L1 Degradation Induced by a Novel Self‐Assembling Hexapeptide for Enhanced Cancer Immunotherapy
Authors: Zhang Hongxia , Ji Ming , Wang Yamei , Jiang Mengmeng , Lv Zongyu , Li Gongyu , Wang Lulu , Zheng Zhen 
Published: November 2024

AbstractProgrammed death‐ligand 1 (PD‐L1) is a critical immune checkpoint protein that facilitates tumor immune evasion. While antibody‐based PD‐1/PD‐L1 inhibitors have shown promise, their limitations necessitate the development of alternative therapeutic strategies. This work addresses these challenges by developing a hexapeptide, KFM (Lys‐Phe‐Met‐Phe‐Met‐Lys), capable of both directly downregulating PD‐L1 and self‐assembling into a ROS‐responsive supramolecular hydrogel. This dual functionality allows Gel KFM to function as a localized drug delivery system and a PD‐L1 inhibitor. Loading the hydrogel with mitoxantrone (MTX) and metformin (MET) further enhances the therapeutic effect by combining chemotherapy with PD‐L1 downregulation. In vitro and in vivo studies demonstrate significant tumor growth inhibition, increased CD8+ T cell infiltration, and reduced intratumoral PD‐L1 expression following peritumoral administration. Mechanistically, KFM promotes PD‐L1 degradation via a ubiquitin‐dependent pathway. This “carrier‐free” delivery system expands the role of supramolecular hydrogels beyond passive carriers to active immunotherapeutic agents, offering a promising new strategy for cancer therapy.