bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scoping review on health economics in neurosurgery for acute spine trauma
Authors: Chan Brian C. F. , Craven B. Catharine , Furlan Julio C. 
Published: May 2018

OBJECTIVEAcute spine trauma (AST) has a relatively low incidence, but it often results in substantial individual impairments and societal economic burden resulting from the associated disability. Given the key role of neurosurgeons in the decision-making regarding operative management of individuals with AST, the authors performed a systematic search with scoping synthesis of relevant literature to review current knowledge regarding the economic burden of AST.METHODSThis systematic review with scoping synthesis included original articles reporting cost-effectiveness, cost-utility, cost-benefit, cost-minimization, cost-comparison, and economic analyses related to surgical management of AST, whereby AST is defined as trauma to the spine that may result in spinal cord injury with motor, sensory, and/or autonomic impairment. The initial literature search was carried out using MEDLINE, EMBASE, CINAHL, CCTR, and PubMed. All original articles captured in the literature search and published from 1946 to September 27, 2017, were included. Search terms used were the following: (cost analysis, cost effectiveness, cost benefit, economic evaluation or economic impact) AND (spine or spinal cord) AND (surgery or surgical).RESULTSThe literature search captured 5770 titles, of which 11 original studies met the inclusion/exclusion criteria. These 11 studies included 4 cost-utility analyses, 5 cost analyses that compared the cost of intervention with a comparator, and 2 studies examining direct costs without a comparator. There are a few potentially cost-saving strategies in the neurosurgical management of individuals with AST, including 1) early surgical spinal cord decompression for acute traumatic cervical spinal cord injury (or traumatic thoracolumbar fractures, traumatic cervical fractures); 2) surgical treatment of the elderly with type-II odontoid fractures, which is more costly but more effective than the nonoperative approach among individuals with age at AST between 65 and 84 years; 3) surgical treatment of traumatic thoracolumbar spine fractures, which is implicated in greater direct costs but lower general-practitioner visit costs, private expenditures, and absenteeism costs than nonsurgical management; and 4) removal of pedicle screws 1–2 years after posterior instrumented fusion for individuals with thoracolumbar burst fractures, which is more cost-effective than retaining the pedicle screws.CONCLUSIONSThis scoping synthesis underscores a number of potentially cost-saving opportunities for neurosurgeons when managing patients with AST. There are significant knowledge gaps regarding the potential economic impact of therapeutic choices for AST that are commonly used by neurosurgeons.
Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases
Authors: Healy David , Le Noury Joanna , Mangin Derelie 
Published: May 2018

OBJECTIVE: To investigate clinical reports of post-SSRI sexual dysfunction (PSSD), post-finasteride syndrome (PFS) and enduring sexual dysfunction following isotretinoin. METHODS: Data from RxISK.org, a global adverse event reporting website, have been used to establish the clinical features, demographic details and clinical trajectories of syndromes of persistent sexual difficulties following three superficially different treatment modalities. RESULTS We report on 300 cases of enduring sexual dysfunction from 37 countries following 14 different drugs comprised of serotonin reuptake inhibiting antidepressants, 5 α-reductase inhibitors and isotretinoin. While reports of certain issues were unique to the antidepressants, such as the onset of premature ejaculation and persistent genital arousal disorder (PGAD), there was also a significant overlap in symptom profile between the drug groups, with common features including genital anaesthesia, pleasureless or weak orgasm, loss of libido and impotence. Secondary consequences included relationship breakdown and impaired quality of life. CONCLUSIONS These data point to a legacy syndrome or syndromes comprising a range of disturbances to sexual function. More detailed studies will require developments in coding systems that recognise the condition(s). Further exploration of these tardive sexual syndromes may yield greater understanding of tardive syndromes in general.
Parents’ attitudes and views regarding antibiotics in the management of respiratory tract infections in children: a qualitative study of the influence of an information booklet
Authors: Dekker Anne RJ , de Groot Esther , Sebalj Tom , Yardley Lucy , Cals Jochen WL , Verheij Theo JM , van der Velden Alike W 
Published: May 2018

BackgroundRespiratory tract infection (RTI) is the most common reason to consult a GP during childhood, and often results in unnecessary prescribing of antibiotics. Using an information booklet during the consultation has been shown to be a promising tool to reduce antibiotic prescribing. The influence of such information on parents’ views, knowledge, and expectations has not been investigated yet.AimTo explore the reported attitude and knowledge of parents towards antibiotics and management of childhood RTI, as well as the added influence of an information booklet, as perceived by parents.Design & settingQualitative interviews were conducted with Dutch parents who consulted the GP with their child for RTI symptoms and received an information booklet.MethodSemi-structured interviews were audio-recorded, transcribed, coded, and analysed using framework analysis by open-axial coding and describing themes.ResultsEighteen parents were interviewed. Four themes were identified: prior reticence towards antibiotics; expectations of the consultation and trust in the GPs’ treatment decision; confirmation and reassurance by the booklet; self-management and future consultation intentions. Dutch parents felt reassured and more confident about their pre-existing reticent attitude towards antibiotic treatment; therefore, they thought their opinion and attitude had not really been changed by the booklet.ConclusionIn a low-prescribing country like the Netherlands, information should focus on enhancing self-efficacy and providing concrete safety-netting advice. For other countries with less reticence towards antibiotics, it is recommended that the knowledge, attitude, and perceptions of the population is studied, in order to be able to tailor interventions.
Confirming Variability in the Secondary Eclipse Depth of the Super-Earth 55 Cancri e
Authors: Tamburo P. , Mandell A. , Deming D. , Garhart E. 
Published: May 2018

Abstract
We present a reanalysis of five transit and eight eclipse observations of the ultrashort-period super-Earth 55 Cancri e observed using the Spitzer Space Telescope during 2011–2013. We use pixel-level decorrelation to derive accurate transit and eclipse depths from the Spitzer data, and we perform an extensive error analysis. We focus on determining possible variability in the eclipse data, as was reported in Demory et al. From the transit data, we determine updated orbital parameters, yielding T
0 = 2,455,733.0037 ± 0.0002, P = 0.7365454 ± 0.0000003 days, i = 83.5 ± 1.°3, and R

p
= 1.89 ± 0.05 R
⊕. Our transit results are consistent with a constant depth, and we conclude that they are not variable. We find a significant amount of variability between the eight eclipse observations and confirm agreement with Demory et al. through a correlation analysis. We convert the eclipse measurements to brightness temperatures, and generate and discuss several heuristic models that explain the evolution of the planet’s eclipse depth versus time. The eclipses are best modeled by a year-to-year variability model, but variability on shorter timescales cannot be ruled out. The derived range of brightness temperatures can be achieved by a dark planet with inefficient heat redistribution intermittently covered over a large fraction of the substellar hemisphere by reflective grains, possibly indicating volcanic activity or cloud variability. This time-variable system should be observable with future space missions, both planned (JWST) and proposed (i.e., ARIEL).
Photon-counting Properties of SAPHIRA APD Arrays
Authors: Atkinson Dani , Hall Donald , Jacobson Shane , Baker Ian M. 
Published: May 2018

Abstract
We measure the ability of the Leonardo Selex Advanced Photodiode HgCdTe Infrared Array (SAPHIRA) avalanche photodiode array to perform photon counting. The current SAPHIRA arrays achieve >90% single-photon efficiency (independent of quantum efficiency expected to be also >90%) and a time resolution of 125 μs with a dark current of 21e
− s−1 pix−1. Our characterization of several iterations of the SAPHIRA detector over the past 3 years of its development have also revealed a broader pulse height distribution than was originally expected.
Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor–negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication
Authors: Aquilani Angela , Marafon Denise Pires , Marasco Emiliano , Nicolai Rebecca , Messia Virginia , Perfetti Francesca , Magni-Manzoni Silvia , De Benedetti Fabrizio 
Published: May 2018

Objective.To evaluate the rate of flare after etanercept (ETN) withdrawal in patients with juvenile idiopathic arthritis (JIA) who attained clinical remission while taking medication, and to identify predictors of flare.Methods.Patients were included with oligo- (oJIA) and rheumatoid factor–negative polyarticular JIA (pJIA) who received a first course of ETN for at least 18 months, maintained clinically inactive disease (CID) for at least 6 months during treatment, and were followed for 12 months after ETN withdrawal. Demographic and clinical features were collected at onset, at baseline (initiation of ETN), and at time of disease flare.Results.After ETN withdrawal, 66 of the 110 patients enrolled (60%) flared with arthritis (of whom 7 flared with concurrent anterior uveitis; none with uveitis alone). The median time to flare was 4.3 months (interquartile range 2.5–6.4) with no evident differences between oJIA and pJIA. The number and type of joints involved at baseline and characteristics of ETN treatment/discontinuation were not associated with flare. Patients who flared were more frequently males (p = 0.034), positive for antinuclear antibody (ANA; p = 0.047), and had higher values of C-reactive protein (CRP; p = 0.012) at baseline. These variables remained significantly associated with flare in a multivariate logistic analysis, a model accounting for only 14% of the variability of the occurrence of the flare.Conclusion.Our results show that a significant proportion of patients with JIA who maintain CID for at least 6 months experience a relapse after ETN withdrawal. Male sex, presence of ANA, and elevated CRP at baseline were associated with higher risk of flare.
Quand l’acte de l’analyste, rencontre « l’agir » de l’enfant : un pari pour que s’instaure le sujet
Authors: Taverna Isabelle 
Published: May 2018

La psychanalyse est une éthique de la parole, cependant, aujourd’hui nous sommes de plus en plus amenés à rencontrer de jeunes patients pour lesquels « l’agir » tient lieu et place d’un « dire ». Ce qu’il nous faut alors créer c’est une place pour le sujet, pour qu’un accès à la parole soit possible. Comment entendre l’agitation chez l’enfant ? Et la « traiter » tout en restant fidèle à l’éthique analytique ? Au travers du parcours d’un enfant, je souhaite illustrer comment l’acte de parole de l’analyste, comme réponse à « l’agir », peut soutenir une place pour le sujet et offrir un accès à la parole.
Les prostitutions – pour une approche ethnographique du trauma
Authors: Maes Renaud 
Published: May 2018

L’approche clinique des prostitutions se fonde fréquemment sur le concept de décorporalisation. Les différents « symptômes » de la décorporalisation doivent cependant être remis en perspective de la multiplicité des situations prostitutionnelles. C’est ce que nous nous proposons de faire au travers d’une approche ethnographique et d’une « sociologie en miroir ». Nous mettons de la sorte en évidence que la description de ces « symptômes » doit être réenvisagée pour mieux prendre en compte les stratégies individuelles, les mécanismes collectifs et les rapports sociaux.
Entre reconnaissance et possibilité de faire mal : l’expérience de l’altérité dans le cas d’une ancienne prisonnière politique de la dictature chilienne
Authors: Bravo Diego , Faúndez Ximena , Palma Evelyn , Brackelaire Jean-Luc 
Published: May 2018

Selon une méthodologie qualitative de type biographique, l’article analyse sur le mode du cas unique le récit de vie d’une femme de 73 ans qui fut prisonnière politique et torturée lors de la dictature civile et militaire chilienne. On cherche à cerner le sens que prend l’autre comme altérité dans son expérience subjective. En premier lieu, c’est la figure de l’autre qui apparait dans le récit de prison, de torture et de violence politique. Dans ce cas, l’altérité se vit dans le passage entre des lieux de confort et d’appui, comme dans la camaraderie politique, et d’autres caractérisés par la violence et la crudité incarnés dans le rôle du tortionnaire et des forces armées. Une situation particulière se produit lorsque l’agresseur est paradoxalement perçu comme un être bon. En deuxième lieu, l’altérité se présente a posteriori, en aval de la situation de violence politique, dans la transmission de cette expérience. Elle prend forme dans le rôle du témoin, comme une expérience réparatrice associée à la reconnaissance qu’elle implique mais à la fois redoutée en raison du risque de « faire mal » au récepteur du récit. En troisième lieu, le cadre de la recherche se présente comme une instance particulière qui fait apparaître la rencontre entre le participant et un autre, chercheur, qui, à l’image de ce qui se produit dans le cas précédent, outre son rôle de chercheur, fait office de témoin.
Les phénomènes addictifs contemporains imposent-ils de repenser nos concepts psychanalytiques ?
Authors: Levaque Cédric 
Published: May 2018

À partir d’un fragment de cure analytique issue de la clinique des phénomènes addictifs, l’auteur démontre en quoi les concepts freudiens et lacaniens restent toujours opérants pour appréhender de la clinique qualifiée, par certains, de « contemporaine ».
L’animal : le plus proche, le plus lointain
Authors: Willems Sandrine 
Published: May 2018

« Mon chien, mon chat, c’est comme mon âme » : si tant d’entre nous ont pu le penser, plus ou moins secrètement, n’est-ce pas que l’animal de compagnie peut nous devenir plus proche qu’un humain ? En nous apportant tout autre chose – lui qui est tout autre que l’humain ? Au point que certains voient en lui une sorte d’incarnation du « divin », de la « grâce » – ce qui est là gratuitement, « pour rien » – sinon, justement, pour faire place à l’âme ?
Le chien, une figure de compagnon polyvalent
Authors: Brohm Jean-Marie 
Published: May 2018

Le chien domestique ( canis familiaris ) est le premier animal domestiqué par l’homme. Présent dans presque toutes les sociétés humaines, il est capable de remplir de très nombreuses fonctions : économiques (chiens de trait), sécuritaires (chiens policiers), militaires (chiens d’assaut), scientifiques (objet de vivisection), humanitaires (chiens guides d’aveugles, chiens sauveteurs, chiens auxiliaires de vie), sportives (chiens de traîneaux, chiens de course), alimentaires (chien de boucherie). Les très nombreuses races de chiens permettent une grande variété de relations de compagnonnage. Si « l’ami le plus fidèle de l’homme » est souvent traité comme un animal familier et même familial en tant que quasi personne et objet d’amour, il est aussi l’objet de nombreuses phobies, d’où l’ambivalence culturelle du chien.
Le vétérinaire, l’animal et son maître
Authors: Bardet Jean-François , de Mijolla-Mellor Sophie , Rubiliani-Lenne Sylvie 
Published: May 2018

Comment et pourquoi devient-on vétérinaire ? Qu’est-ce qui fascine ce dernier chez l’animal de compagnie ? Soigne t’il d’ailleurs uniquement l’animal ou bien aussi le maître ? Pourquoi les gens ont-ils des animaux de compagnie ? Telles sont les questions auxquelles Jean-François Bardet a accepté de répondre à partir de sa longue pratique de chirurgien vétérinaire en ville.
La relation de l’homme au chien familier : symptôme de sa dynamique psychique ?
Authors: Elies Christel , Schauder Silke 
Published: May 2018

L’évolution de la société humaine a entraîné une transformation de la place accordée aux animaux domestiques. Humanisé, le chien s’est vu élevé au rang de membre de la famille. Simple ersatz de parentalité ou néo-relation objectale ? Cet article propose une réflexion sur les mouvements psychiques mis en jeu dans notre relation au chien familier, de son acquisition à sa mort. Quand les interactions dysfonctionnent, le chien peut manifester des comportements répétitifs et devenir le symptôme de son propriétaire.
La relation homme-animal au nouage de la médiation thérapeutique avec le cheval
Authors: Bouillon Charlotte 
Published: May 2018

Les processus psychiques qui se jouent au nouage de la relation homme-animal seront abordés, dans cet article, sur le versant de la médiation thérapeutique avec le cheval. Quels enjeux animent le clinicien et le patient qui se rejoignent dans le désir de s’inscrire dans une telle clinique ? L’auteur s’attache à cerner, en s’appuyant sur sa pratique clinique et son expertise, en quoi la dimension du Réel est contactée dans cette rencontre particulière dans laquelle l’imprévisibilité bienveillante du cheval en fait un partenaire thérapeutique privilégié.
« Malwâââ... » , le nom de la frontière
Authors: Vernet Anne 
Published: May 2018

Méditation sur un compagnonnage de douze ans avec quatre chiens et un chat. À travers les âges de leurs vies s’égrène la communication entre mammifères « debout et non debout ». La question de la Voix animale, du chant et du langage s’y articule avec celles du chaînon manquant et de la servitude partagée. Questionnement qui éclaire en clair-obscur le passage douloureux de la Voix refoulée à la parole au cours du processus analytique.
Survival of Patients With Severe Acute Respiratory Distress Syndrome Treated Without Extracorporeal Membrane Oxygenation
Authors: Sahetya Sarina K. , Brower Roy G. , Stephens R. Scott 
Published: May 2018

Background
Case series have reported favorable outcomes with extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome. However, those patients were generally young, with few comorbid conditions.

Objective
To characterize the clinical features and survival rates of patients with severe acute respiratory distress syndrome who met criteria for ECMO but were managed without it.

Methods
Patients who met the study criteria were identified prospectively. Inclusion criteria for ECMO included severe hypoxemia, uncompensated hypercapnia, or elevated end-inspiratory plateau pressures despite low tidal volume ventilation. Predicted survival rates with ECMO were calculated using the Respiratory ECMO Survival Prediction score.

Results
Of the 46 patients who met the criteria for severe acute respiratory distress syndrome and ECMO consideration, 5 received ECMO and 16 patients had at least 1 contraindication to it. The remaining 25 patients met ECMO criteria but did not receive the treatment. The patients’ mean age was 53.5 (SD, 14.3) years; 84% had at least 1 major comorbid condition. The median predicted survival rate with ECMO was 57%. The actual hospital discharge survival rate without ECMO was 56%.

Conclusions
The general medical intensive care patient population with severe acute respiratory distress syndrome is older and sicker than patients reported in prior case series in which patients were treated with ECMO. In this study, the survival rate without ECMO was similar to predicted survival rates with ECMO.
INFECTIOUS RISKS AND COMPLICATIONS IN ADULT LEUKEMIC PATIENTS RECEIVING BLINATUMOMAB
Authors: So Wonhee , Pandya Shuchi , Quilitz Rod , Quilitz Rod , Greene John 
Published: May 2018

Background: Blinatumomab is an anti-CD19 immunotherapy approved for relapsed/refractory B-cell acute lymphoblastic leukemia (ALL) with significantly increased survival rate. While blinatumomab showed lower rates of infection, neutropenia and mucosal barrier injury versus chemotherapy, its infection risks are not well described. Methods: All patients who received blinatumomab for ≥ 7 days at an academic cancer center from May 2015 to April 2017 were included. Patient characteristics pertinent to infectious risks and complications were examined.Results: Twenty patients with refractory (25%), relapsed (70%), or remitted (5%) B-ALL who received a total of 35 cycles were included. Ten of the 35 cycles were interrupted, none of which were due to infections. Twenty six infections (n) were observed with lower respiratory (9), gastrointestinal (6) and bacteremia (5) being most common. Compared to patients without nodular, possible mold pneumonia (n=16), patients with nodular pneumonia (n=4) had significantly lower baseline absolute neutrophil count (ANC) (2319 v. 208/µL, p=0.011). There were no differences in baseline characteristics including ANC between bacteremic and non-bacteremic patients. One patient was discharged with no antibacterial prophylaxis since ANC recovered to >500cells/µL, but developed Pseudomonal bacteremia within a week with ANC ~100cells/µL. Conclusion: Despite blinatumomab’s relatively modest myelosuppression and the lack of mucotoxicity, host factors (e.g., duration and degree of neutropenia/lymphopenia) play a key role and should be considered when choosing anti-microbial prophylaxis. In relapsed/refractory disease, the ANC should be monitored closely post blinatumomab since neutropenia can unexpectedly develop after treatment which may be compounded by the underlying disease and recent chemotherapy effects.
Application of Standardized Observation Form in School Counselling in Taiwan: Exploratory Study with Children Exhibiting Internalizing and Externalizing Behavior Concerns
Authors: Tsai Mei-Hsiang 
Published: May 2018

The exploratory study investigated the impact of Child-Centered Play Therapy (CCPT) on children who present with internalizing and externalizing behavioral concerns through a single-case design. Two second-grade male children in northern Taiwan displaying clinical levels of internalizing or externalizing behavior problems underwent 9 weeks of weekly 40-minute CCPT sessions. The children’s parents and teachers completed the Child Behavior Checklist and Teacher’s Report Form before and after play therapy. Observational data were collected via the Direct Observation Form throughout the baseline, intervention, and follow-up phases. Observation data were evaluated through visual analysis. In-session play therapy notes and the children’s play therapy behavior scores were also analyzed. The participants’ internalizing and externalizing problem behaviors demonstrated slight decreases.