bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasmonic Retrofitting of Membrane Materials: Shifting from Self‐Regulation to On‐Command Control of Fluid Flow
Authors: Sousa‐Castillo Ana , Furini Leonardo N. , Tiu Brylee David B. , Cao Peng‐Fei , Topçu Begüm , Comesaña‐Hermo Miguel , Rodríguez‐González Benito , Baaziz Walid , Ersen Ovidiu , Advincula Rigoberto C. , Pérez‐Lorenzo Moisés , Correa‐Duarte Miguel A. 
Published: July 2018

AbstractThis work calls for a paradigm shift in order to change the operational patterns of self‐regulated membranes in response to chemical signals. To this end, the fabrication of a retrofitting material is introduced aimed at developing an innovative generation of porous substrates endowed with symbiotic but fully independent sensing and actuating capabilities. This is accomplished by transferring carefully engineered plasmonic architectures onto commercial microfiltration membranes lacking of such features. The integration of these materials leads to the formation of a coating surface proficient for ultrasensitive detection and “on‐command” gating. Both functionalities can be synergistically modulated by the spatial and temporal distribution of an impinging light beam offering an unprecedented control over the membrane performance in terms of permeability. The implementation of these hybrid nanocomposites in conventional polymeric porous materials holds great potential in applications ranging from intelligent fluid management to advanced filtration technologies and controlled release.
One‐Step Construction of N,P‐Codoped Porous Carbon Sheets/CoP Hybrids with Enhanced Lithium and Potassium Storage
Authors: Bai Jing , Xi Baojuan , Mao Hongzhi , Lin Yue , Ma Xiaojian , Feng Jinkui , Xiong Shenglin 
Published: July 2018

AbstractDespite the desirable advancement in synthesizing transition‐metal phosphides (TMPs)‐based hybrid structures, most methods depend on foreign‐template‐based multistep procedures for tailoring the specific structure. Herein, a self‐template and recrystallization–self‐assembly strategy for the one‐step synthesis of core–shell‐like cobalt phosphide (CoP) nanoparticles embedded into nitrogen and phosphorus codoped porous carbon sheets (CoP⊂NPPCS), is first proposed. Relying on the unusual coordination ability of melamine with metal ions and the cooperative hydrogen bonding of melamine and phytic acid to form a 2D network, a self‐synthesized single precursor can be attained. Importantly, this approach can be easily expanded to synthesize other TMPs⊂NPPCS. Due to the unique compositional and structural characteristics, these CoP⊂NPPCSs manifest outstanding electrochemical performances as anode materials for both lithium‐ and potassium‐ion batteries. The unusual hybrid architecture, the high specific surface area, and porous features make the CoP⊂NPPCS attractive for other potential applications, such as supercapacitors and electrocatalysis.
Copper‐Catalyzed Asymmetric Ring‐Opening of Cyclic Diaryliodonium with Benzylic and Aliphatic Amines
Authors: Xu Shibo , Zhao Kun , Gu Zhenhua 
Published: July 2018

AbstractA Cu‐catalyzed asymmetric ring‐opening reaction between cyclic diaryliodonium and benzylic or aliphatic amines has been developed. At low concentration of the amines, realized by either mixing the amines with Lewis acid or slow addition of the amines, the reaction afforded the products in high enantioselectivity.magnified image
Preparation of polymers of intrinsic microporosity composite membranes incorporated with modified nano‐fumed silica for butanol separation
Authors: Lan Yongqiang , Peng Ping , Chen Ping 
Published: July 2018

AbstractIn this work, the modified nano‐fumed silica particles (MNFS) as fillers were incorporated into the polymer of intrinsic microporosity (PIM‐1) matrix to fabricate composite membranes for removing butanol from water. A range of characterization techniques was employed to analyze the properties and pervaporation (PV) performances of the composite membranes. It was found that the addition of MNFS into the PIM‐1 matrix dramatically decreased the swelling degree as compared to pure PIM‐1, implying an increment of the stability of separation performances. Moreover, the PV performances of the composite membranes were significantly enhanced, and the superior PV performances were on account of the following reasons: there was a good compatibility between PIM‐1 and MNFS; and the incorporation of MNFS improved the hydrophobicity of the membranes and disrupted the packing of polymer chains, therefore providing special channels for rapid transport of butanol molecules.
Clinical Informatics Competencies in the Emergency Medicine Specialist Training Standards of Five International Jurisdictions
Authors: Holroyd Brian R. , Beeson Michael S. , Hughes Thomas , Kurland Lisa , Sherbino Jonathan , Truesdale Melinda , Hersh William 
Published: July 2018

AbstractBackgroundThe field of clinical informatics (CI), and specifically the electronic health record, has been identified as a key facilitator to achieve a sustainable evidence‐based health care system for the future. International graduate medical education (GME) programs have been challenged to ensure that their trainees are provided with appropriate skills to deliver effective and efficient health care in an evolving environment.ObjectivesThis study explored how international emergency medicine (EM) specialist training standards address competencies and training in relevant areas of CI.MethodsA list of categories of CI competencies relative to EM was developed following a thematic review of published references documenting CI curriculum and competencies. Publicly available documents outlining core content, curriculum, and competencies from international organizations responsible for specialty GME and/or credentialing in EM for Australasia, Canada, Europe, the United Kingdom, and the United States were identified. These EM training standards were reviewed to identify inclusion of topics related to the relevant categories of CI competencies.ResultsA total of 23 EM curriculum documents were included in the review. Curricula content related to critical appraisal/evidence‐based medicine, leadership, quality improvement, and privacy/security were included in all EM curricula. The CI topics related to fundamental computer skills, computerized provider order entry, and patient‐centered informatics were only included in the EM curricula documents for the United States and were absent for the other jurisdictions.ConclusionThere is variation in the CI‐related content of the international EM specialty training standards reviewed. Given the increasing importance of CI in the future delivery of health care, organizations responsible for training and credentialing specialist emergency physicians must ensure that their training standards incorporate relevant CI content, thus ensuring that their trainees gain competence in essential aspects of CI.
Agricultural injuries among farm and non‐farm children and adolescents in Alberta, Canada
Authors: Kim Kyungsu , Beach Jeremy , Senthilselvan Ambikaipakan , Yiannakoulias Niko , Svenson Larry , Kim Hyocher , Voaklander Donald C. 
Published: July 2018

BackgroundUnderstanding of the specific risk of agricultural injury sustained by different populations of children and adolescents is needed for effective safety intervention.ObjectiveTo compare the rates and patterns of agricultural injury incidence (fatal and non‐fatal injury) between farm and non‐farm children less than 18 years of age in Alberta, Canada.MethodsA total of 115 378 children (five subgroups: two groups of farm children and three groups of non‐farm children) in Alberta were followed from 1999 to 2010 to examine injury incidence using the linkage of three administrative health databases. A recurrent event survival analysis using Cox proportional hazards regression was carried out.ResultsA total of 1 849 agricultural injury episodes (1 616 emergency department visits, 225 hospitalizations, and 8 deaths) were identified from 1999 to 2010. The age‐ and gender‐adjusted rate (per 100 000 person years) of agricultural injury was 672.3 for rural‐living farm children, 369.4 for urban‐living farm children, 180.2 for rural non‐First Nations (FN) children, 64.4 for rural FN children, and 23.7 for urban children in descending order.ConclusionSpecific strategies for different children's populations to prevent agricultural injuries and to extend agricultural injury controls to non‐farming populations are needed.
VCD‐Verstärkung durch chirale Packungseffekte in molekularen Kristallen
Authors: Jähnigen Sascha , Scherrer Arne , Vuilleumier Rodolphe , Sebastiani Daniel 
Published: July 2018

AbstractWir zeigen, dass Molekülschwingungen, die für sich genommen ein niedriges bis kein Signal für Schwingungszirkulardichroismus (vibrational circular dichroism, VCD) aufweisen, durch koordinierte Bewegung der Atome Chiralität annehmen. Unsere Ab‐initio‐Molekulardynamiksimulationen des anharmonischen VCD‐Festphasen‐Spektrums von l‐Alaninkristallen offenbaren, wie kollektive Schwingungsmoden die Chiralität der Raumgruppe ausbeuten und so zu nicht‐lokalen, verstärkten VCD‐Signalen führen, insbesondere in der Carbonyl‐Region des Spektrums. Die verstärkten VCD‐Signaturen basieren auf einer helikalen Anordnung von molekularen Oszillatoren in den Kristallebenen. Um die Amplifikation zu erkären, bedarf es keiner Betrachtung struktureller Unregelmäßigkeiten, wohl aber einer akkuraten Beschreibung der Elektronenstruktur zur Berechnung der Ladungspolarisation. Unser Ab‐initio‐Ansatz liefert ein quantitatives, atomistisches Bild von supramolekularem Chiralitätstransfer. Damit erstreckt sich sein Anwendungsfeld über das der molekularen Kristalle hinaus, z. B. zur Beschreibung von VCD in Proteinen und ähnlichen Verbindungen.
Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase
Authors: Sanzhaeva Urikhan , Xu Xuan , Guggilapu Priyaankadevi , Tseytlin Mark , Khramtsov Valery V. , Driesschaert Benoit 
Published: July 2018

AbstractEnzyme activities are well established biomarkers of many pathologies. Imaging enzyme activity directly in vivo may help to gain insight into the pathogenesis of various diseases but remains extremely challenging. In this communication, we report the use of EPR imaging (EPRI) in combination with a specially designed paramagnetic enzymatic substrate to map alkaline phosphatase activity with a high selectivity, thereby demonstrating the potential of EPRI to map enzyme activity.
(P,C) Cyclometalated Gold(III) Complexes: Highly Active Catalysts for the Hydroarylation of Alkynes
Authors: Blons Charlie , Mallet‐Ladeira Sonia , Amgoune Abderrahmane , Bourissou Didier 
Published: July 2018

AbstractThe first catalytic application of well‐defined (P,C) cyclometalated gold(III) complexes is reported. The bench‐stable bis(trifluoroacetyl) complexes 2 a,b perform very well in the intermolecular hydroarylation of alkynes. The reaction is broad in scope, it proceeds within few hours at 25 °C at catalytic loadings of 0.1–5 mol %. The electron‐rich arene adds across the C≡C bond with complete regio‐ and stereo‐selectivity. The significance of well‐defined gold(III) complexes and ligand design are highlighted in a powerful but challenging catalytic transformation.
A Self‐Digitization Dielectrophoretic (SD‐DEP) Chip for High‐Efficiency Single‐Cell Capture, On‐Demand Compartmentalization, and Downstream Nucleic Acid Analysis
Authors: Qin Yuling , Wu Li , Schneider Thomas , Yen Gloria S. , Wang Jiasi , Xu Shihan , Li Min , Paguirigan Amy L. , Smith Jordan L. , Radich Jerald P. , Anand Robbyn K. , Chiu Daniel T. 
Published: July 2018

AbstractThe design and fabrication of a self‐digitization dielectrophoretic (SD‐DEP) chip with simple components for single‐cell manipulation and downstream nucleic acid analysis is presented. The device employed the traditional DEP and insulator DEP to create the local electric field that is tailored to approximately the size of single cells, enabling highly efficient single‐cell capture. The multistep procedures of cell manipulation, compartmentalization, lysis, and analysis were performed in the integrated microdevice, consuming minimal reagents, minimizing contamination, decreasing lysate dilution, and increasing assay sensitivity. The platform developed here could be a promising and powerful tool in single‐cell research for precise medicine.
Oxidation of o‐phenylenediamine to 2,3‐diaminophenazine in the presence of cubic ferrites MFe2O4 (M = Mn, Co, Ni, Zn) and the application in colorimetric detection of H2O2
Authors: Vetr Fahime , Moradi‐Shoeili Zeinab , Özkar Saim 
Published: July 2018

Metal ferrites nanocrystallites, MFe2O4 (M = Mn, Co, Ni, Zn) were prepared by coprecipitation method and characterized by a combination of physico‐chemical and spectroscopic techniques. MFe2O4 nanoparticles having particle size in the range 10–35 nm were tested as catalysts in the oxidation of o‐phenylenediamine (OPD) to 2,3–diaminophenazine (DAP) using hydrogen peroxide as oxidant at room temperature. Kinetic data was collected for the catalytic oxidation of OPD to DAP by monitoring the UV–vis absorbance at 415 nm and fit well to the Michaelis–Menten model yielding kinetic parameters Km (Michaelis–Menten constant) and Vmax (maximum rate of reaction). MnFe2O4 nanoparticles provide the highest catalytic activity in the oxidation of OPD to DAP at room temperature. A colorimetric method was developed based on the MnFe2O4/OPD system for the detection of H2O2 in reaction solution. The method has a detection limit of 30 μM for H2O2 and wide linear range.
Synthesis, spectral, structural characterization and biological activity of new palladium(II) complexes containing 3‐acetyl‐8‐methoxy‐2H‐chromen‐2‐one derived Schiff bases
Authors: Kalaiarasi G. , Aswini G. , Rex Jeya Rajkumar S. , Dharani S. , Lynch Vincent M. , Prabhakaran R. 
Published: July 2018

Four different mononuclear palladium(II) complexes of 3‐acetyl‐8‐methoxycoumarin Schiff bases were synthesized and characterized by spectrochemical techniques. Further analysis through X‐ray crystallography confirmed the structures of the complexes. Their interactive ability with Calf Thymus DNA and protein (Bovine Serum Albumin and Human Serum Albumin) were investigated by means of absorption and emission methods. The intercalative mode of binding with DNA was supported by EB displacement studies and viscosity measurements. Configurational changes that occurred in the proteins have been analysed with the help of 3D fluorescence studies. The complexes were shown to have good antimicrobial activity against the tested bacterial and fungal pathogens. In addition, antiproliferative activity of the complexes was evaluated on A549 and MCF‐7 cell lines and the complexes were comparatively more active than the standard drug cisplatin. Among the compounds, complex 3 was the most effective against MCF‐7 (IC50 value of 5.20 ± 0.15 μM) and A549 (5.09 ± 0.13 μM) compared with the other complexes 1 (6.48 ± 0.17 μM; 5.98 ± 0.09 μM), 2 (5.53 ± 0.12 μM; 5.85 ± 0.11 μM), 4 (6.73 ± 0.19 μM; 6.63 ± 0.16 μM) and cisplatin (16.79 ± 0.08 μM; 15.10 ± 0.05 μM) respectively. LDH and NO release assays confirmed the cytotoxic potential of the synthesized complexes.
Physical Properties of Candelilla Wax, Monoacylglycerols, and Fully Hydrogenated Oil Oleogels
Authors: da Silva Thais L. T. , Arellano Daniel B. , Martini Silvana 
Published: July 2018

AbstractOleogels have been studied in the past decade due to their potential to replace saturated fat in foods. Oleogelators have been mostly studied alone or in binary systems. Sometimes a single oleogelator cannot achieve all the technological properties necessary for a specific food application. Thus, the aim of this work was to investigate the interaction between candelilla wax (CLX), monoacylglycerols (MAG), and a fully hydrogenated oil (hardfat [HF]) in soybean and high‐oleic sunflower oils and to evaluate their physical properties. The concentration of the total oleogelator was between 5% and 10%, from pure CLX (5%), sample OP, up to many combinations of MAG, HF, and CLX samples O1, O2, O3, O4, O5, and O6. Samples were evaluated according to their microstructure, melting properties, rheological behavior, hardness, oil‐binding capacity (OBC), and thermal stability. Results showed that the addition of MAG and HF to CLX created a softer gel but improved its rheological properties. Changes in the physical properties were related to the various proportions of CLX, MAG, and HF rather than the overall concentration of structuring agents. For example, for a total concentration of 5% of the structuring agent, a decrease in the CLX concentration from 5% to 3% and the addition of HF and MAG resulted in a softer crystalline network. Increasing the overall concentration of oleogelators by increasing the amount of HF and/or MAG and maintaining the concentration of the CLX constant did not improve the hardness of the gel. This study showed that at least 3% of CLX must be added to the system to obtain a semisolid material independently of the amount of MAG and/or HF added.
ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment
Authors: Janczi Tomasz , Böhm Beate B. , Fehrl Yuliya , DeGiacomo Pangrazio , Kinne Raimund W. , Burkhardt Harald 
Published: July 2018

ObjectiveTo investigate mechanisms underlying the capability of ADAM15 to transform FasL‐mediated death‐inducing signals into prosurvival activation of Src and focal adhesion kinase (FAK) in rheumatoid arthritis synovial fibroblasts (RASFs).MethodsCaspase 3/7 activity and apoptosis rate were determined in RASFs and ADAM15‐transfected T/C28a4 cells upon Fas/CD95 triggering using enzyme assays and annexin V staining. Phosphorylated Src and FAK were analyzed by immunoblotting. Interactions of ADAM15 and CD95 with calmodulin (CaM), Src, or FAK were analyzed by pull‐downs using CaM–Sepharose and coimmunoprecipitations with specific antibodies. Protein binding assays were performed using recombinant CaM and ADAM15. Immunofluorescence was performed to investigate subcellular colocalization of ADAM15, Fas/CD95, and CaM.ResultsThe antiapoptotic effect of ADAM15 in FasL‐stimulated cells was demonstrated either by increased apoptosis of cells transfected with an ADAM15 construct lacking the cytoplasmic domain compared to cells transfected with full‐length ADAM15 or by reduced apoptosis resistance of RASFs upon RNA interference silencing of ADAM15. Fas ligation triggered a Ca2+ release‐activated Ca2+/calcium release‐activated calcium channel protein 1 (CRAC/Orai1) channel–dependent CaM recruitment to Fas/CD95 and ADAM15 in the cell membrane. Simultaneously, Src associated with CaM was shown to become engaged in the ADAM15 complex also containing cytoplasmic‐bound FAK. Accordingly, Fas ligation in RASFs led to ADAM15‐dependent phosphorylation of Src and FAK, which was associated with increased survival. Pharmacologic interference with either the CaM inhibitor trifluoperazine or the CRAC/Orai inhibitor BTP‐2 simultaneously applied with FasL synergistically enhanced Fas‐mediated apoptosis in RASFs.ConclusionADAM15 provides a scaffold for formation of CaM‐dependent prosurvival signaling complexes upon CRAC/Orai coactivation by FasL‐induced death signals and a potential therapeutic target to break apoptosis resistance in RASFs.
Efficiency consideration of generalized age replacement policy
Authors: Park Minjae , Jung Ki Mun , Kim Jennifer Jae‐Young , Park Dong Ho 
Published: July 2018

AbstractUnder the generalized age replacement policy, the system is replaced either at the predetermined age or upon failure if its corresponding repair time exceeds the threshold, whichever comes first. In this paper, we investigate the optimal choice of the pre‐determined preventive replacement age for a nonwarranted system, which minimizes the expected cost rate during the life cycle of the system from the customer's perspective under certain cost structures. Furthermore, we discuss several properties of such a generalized age replacement policy in comparison with the traditional age replacement policy. An efficiency, which represents the fractional time that the system is on, is defined under the proposed generalized age replacement policy and its monotonicity properties are investigated as well. The main objective of this study is to investigate the advantageous features of the generalized age replacement policy over the traditional age replacement policy with regard to the availability of the repairable system. Assuming that the system deteriorates with age, we illustrate our proposed optimal policies numerically and observe the impact of relevant parameters on the optimal preventive replacement age.
Brandeinwirkung auf Holzbauteile im Prüfofen und bei realen Bränden
Authors: Schmid Joachim , Klippel Michael , Fahrni Reto , Frangi Andrea 
Published: July 2018

AbstractBrandschutzexperten diskutieren derzeit die Gültigkeit von Brandprüfungen für Holzbauteile. Im Raum steht einerseits die allgemeine Aussage, dass brennbare Bauteile in Prüfungen einer von nicht brennbaren Bauteilen abweichenden thermischen Einwirkung ausgesetzt werden. Andererseits wird darauf hingewiesen, dass die sichere Verwendung von flächigen Holzbauteilen (Massivholzbauteile), z. B. Brettsperrholz, durch Normbrandprüfungen nicht geprüft werden kann, da diese Bauteile die Brandlast erhöhen und somit keine Aussagen im traditionellen Rahmenwerk des Feuerwiderstands getätigt werden können. Der vorliegende Beitrag zeigt Übereinstimmungen und Unterschiede zwischen nicht brennbaren und brennbaren Bauteilen in Normbrandprüfungen auf. Es wird gezeigt, dass die thermische Einwirkung für nicht brennbare und brennbare Bauteile in Normbrandprüfungen gleichwertig ist, auch wenn es sich um – wie im Falle von Brettsperrholz – großflächige Bauteile handelt. Die durch brennbare Bauteile zusätzlich im Brandraum verbrennende Brandlast kann durch Normbrandprüfungen nicht direkt ermittelt werden. Hierfür müssen, falls notwendig, andere Methoden verwendet werden, die zum Teil erst in der Entwicklung stehen. Die durch brennbare raumbildende Tragstrukturen zusätzliche Brandlast führt nicht zu höheren Temperaturen im Brandraum, sondern zu einer veränderten Brandeinwirkung an der Fassade. Diesem Umstand wird im Moment in Bauordnungen durch verschiedene Regeln Rechnung getragen.
Construction of a novel turn‐on–off fluorescence sensor used for highly selective detection of thiamine via its quenching effect on o‐phen‐Zn2+ complex
Authors: Zhang Hui , Chen Hongyun , Li Hongxi , Pan Shuang , Ran Yalin , Hu Xiaoli 
Published: July 2018

AbstractIn this work, a simple and selective fluorescence sensor approach called ‘turn‐on–off’ for the determination of thiamine (TM) has been developed. As known, the o‐phenanthroline (o‐phen) has inner fluorescence, though when reacted with zinc ions to form the o‐phen–Zn2+ complex the fluorescence intensity was enhanced effectively, while upon addition of TM into the o‐phen–Zn2+ complex solution, the intensity of the system was gently quenched, which was termed the ‘turn‐on–off’ probe. Notably, the method possessed highly selective, sensitive determination for TM with a detection limit of 0.25 μmol L−1 and the reduced fluorescence intensity was proportional to the concentration of TM in the range 0.84–80.0 μmol L−1. Besides, the proposed mechanism was also investigated through exploring the Fourier transform infrared (FT‐IR), nuclear magnetic resonance (NMR) spectroscopy. Furthermore, this manner was successfully applied into practical samples for TM detection with satisfactory results.