bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Robust Data Envelopment Analysis for Evaluating Technical Efficiency of Indonesian High Schools
Authors: Mahmudah U. , Suhartono S. , Rohayana A. D. 
Published: July 2018

The main purpose of this study is to evaluate the technical efficiency of high school education in Indonesia by applying Data Envelopment Analysis (DEA), which is the most frequently used to measure the efficiency scores. However, this study uses a robust approach to face the complex problem of the traditional DEA, which may lead to biased results. Besides, it is a powerful approach to estimate technical efficiency when outliers contaminate the data set. Statistical data from general senior secondary schools in the period 2015/2016 is analyzed, using 34 provinces as decision-making units (DMUs), with eight input and six output variables. The results indicate that the average efficiency score of Indonesia’s major political subdivisions in managing high school education is 0.936. Furthermore, as many as 32.35 percents of provinces achieve efficient performances, with an efficiency score equal to one, while 17 provinces have above average efficiency scores. The results also indicate that efficiency scores from robust data envelopment analysis provide better accuracy. Overall, application of robust data envelopment analysis (RDEA) is appropriate for measuring the efficiency of provincial performance in organizing secondary education.
The Influence of Inquiry-Based Science Issues Learning on Practical Skills of Junior High School Students in Environmental Pollution Topic
Authors: Hastuti P. W. , Tiarani V. A. , Nurita T. 
Published: July 2018

Inquiry-based science issues approach facilitates the development of scientific skills through research activities on surrounding science issues. The purpose of this research was to understand the influence of Inquiry-based science issues on practical skills of Junior High School students. This research employed quasi-experimental research method, equipped with pre-test, post-test non-equivalent control group design. The sample of sixty junior high school students in Yogyakarta was picked for this study. The instruments used were observation sheets on practical skills, practical skills test, and instructional learning sheets. The data collected were analyzed using N-Gain, percentage, and Analysis of Covariate (ANCOVA) at 0.05 significance level. The result revealed that Inquiry Science Issues was more effective in fostering students’ practical skills than the scientific approach. There was a significant effect of treatment on students’ practical skills while no interaction between approach and prior knowledge of students. Moreover, the data of practical skills through the observation sheets in the experimental class had higher percentage compared to the control class, 80.36%, and 70.61% respectively.
Rapid Low-Cost Assembly of the Drosophila melanogaster Reference Genome Using Low-Coverage, Long-Read Sequencing
Authors: Solares Edwin A , Chakraborty Mahul , Miller Danny E , Kalsow Shannon , Hall Kate , Perera Anoja G , Emerson J J , Hawley R Scott 
Published: July 2018

Abstract
Accurate and comprehensive characterization of genetic variation is essential for deciphering the genetic basis of diseases and other phenotypes. A vast amount of genetic variation stems from large-scale sequence changes arising from the duplication, deletion, inversion, and translocation of sequences. In the past 10 years, high-throughput short reads have greatly expanded our ability to assay sequence variation due to single nucleotide polymorphisms. However, a recent de novo assembly of a second Drosophila melanogaster reference genome has revealed that short read genotyping methods miss hundreds of structural variants, including those affecting phenotypes. While genomes assembled using high-coverage long reads can achieve high levels of contiguity and completeness, concerns about cost, errors, and low yield have limited widespread adoption of such sequencing approaches. Here we resequenced the reference strain of D. melanogaster (ISO1) on a single Oxford Nanopore MinION flow cell run for 24 hr. Using only reads longer than 1 kb or with at least 30x coverage, we assembled a highly contiguous de novo genome. The addition of inexpensive paired reads and subsequent scaffolding using an optical map technology achieved an assembly with completeness and contiguity comparable to the D. melanogaster reference assembly. Comparison of our assembly to the reference assembly of ISO1 uncovered a number of structural variants (SVs), including novel LTR transposable element insertions and duplications affecting genes with developmental, behavioral, and metabolic functions. Collectively, these SVs provide a snapshot of the dynamics of genome evolution. Furthermore, our assembly and comparison to the D. melanogaster reference genome demonstrates that high-quality de novo assembly of reference genomes and comprehensive variant discovery using such assemblies are now possible by a single lab for under $1,000 (USD).
Event Analysis: Using Transcript Events To Improve Estimates of Abundance in RNA-seq Data
Authors: Newman Jeremy R B , Concannon Patrick , Tardaguila Manuel , Conesa Ana , McIntyre Lauren M 
Published: July 2018

AbstractAlternative splicing leverages genomic content by allowing the synthesis of multiple transcripts and, by implication, protein isoforms, from a single gene. However, estimating the abundance of transcripts produced in a given tissue from short sequencing reads is difficult and can result in both the construction of transcripts that do not exist, and the failure to identify true transcripts. An alternative approach is to catalog the events that make up isoforms (splice junctions and exons). We present here the Event Analysis (EA) approach, where we project transcripts onto the genome and identify overlapping/unique regions and junctions. In addition, all possible logical junctions are assembled into a catalog. Transcripts are filtered before quantitation based on simple measures: the proportion of the events detected, and the coverage. We find that mapping to a junction catalog is more efficient at detecting novel junctions than mapping in a splice aware manner. We identify 99.8% of true transcripts while iReckon identifies 82% of the true transcripts and creates more transcripts not included in the simulation than were initially used in the simulation. Using PacBio Iso-seq data from a mouse neural progenitor cell model, EA detects 60% of the novel junctions that are combinations of existing exons while only 43% are detected by STAR. EA further detects ∼5,000 annotated junctions missed by STAR. Filtering transcripts based on the proportion of the transcript detected and the number of reads on average supporting that transcript captures 95% of the PacBio transcriptome. Filtering the reference transcriptome before quantitation, results in is a more stable estimate of isoform abundance, with improved correlation between replicates. This was particularly evident when EA is applied to an RNA-seq study of type 1 diabetes (T1D), where the coefficient of variation among subjects (n = 81) in the transcript abundance estimates was substantially reduced compared to the estimation using the full reference. EA focuses on individual transcriptional events. These events can be quantitate and analyzed directly or used to identify the probable set of expressed transcripts. Simple rules based on detected events and coverage used in filtering result in a dramatic improvement in isoform estimation without the use of ancillary data (e.g., ChIP, long reads) that may not be available for many studies.
Psychoneurology in the province: works and days of Mikhail Dobrokhotov at the edge of the centuries
Authors: Manyshev S. B. , Manysheva K. B. 
Published: July 2018

The article is devoted to the unexplored period of life of the famous Russian neurologist and psychiatrist of the first half of the 20th century Mikhail Sergeyevich Dobrokhotov (1878–1952). Based on the first time archived materials brought into scientific circulation from the funds of the State Archives of the Rostov Region, the Central State Archives of the Republic of Dagestan, the archive of the Dagestan State Medical University, the milestones of the life path of the privat-docent M.S. Dobrokhotov in the city of Rostov-on-Don, where he lived and worked during the Civil War. The authors consider the multifaceted activity of M.S. Dobrokhotov in the Don University. For the period of the Civil War, the most difficult years occur in the history of the medical faculty, at the department of psychoneurology of which the university professor M.S. Dobrokhotov. The authors focus on the functioning of the health care system of the Don region in the period under review. A separate place is given to the history of the department and the clinic of psycho-neurology of the University, since after the First World War the number of patients with psycho-neurological disorders increased sharply. In addition, on the basis of archival materials, the history of the Don Traumatology Institute is being reconstructed, the director of which was M.S. Dobrokhotov. It was in this institution that the combatants were provided with specialized medical care: the treatment of fractures, contractures, paralysis, neuroses, and lesions of the central and peripheral nervous system. The article reveals the history of the creation of the Rostov Society of Doctors-Psycho-Neurologists, whose members were famous Russian scientists A.I. Yushchenko, S.N. Davidenkov, K.S. Agadzhanyants, V.V. Brailovsky, N.M. Itsenko, N.M. Krol’ and others. A certain place is also given to M.S. Dobrokhotov in the post of head of the psychiatric section of the Don Regional Department of Health.
Explore the Development and Application of Electrical Automation Control Systems
Authors: Niu Zhishan , Zhao Yanfeng , Hu Junjun , Wang Deyong , Dong Lin , Wang Lijun 
Published: July 2018

The development of electrical automation engineering control system is the foundation of modern industrial development in China, and also an important embodiment of the rapid development of modern technology. The application of electric automation technology can not only improve work efficiency, but also reduce enterprise cost. Based on this, the current situation and development trend of electrical automation engineering control system are studied for reference by relevant staff.
CHEMOMETRIC-BASED ELECTRONIC NOSE APPLICATION TO PORK OIL AND OLIVE OIL USING THE ODOR PATTERN CLASSIFICATIONS
Authors: Tazi Imam , Muthmainnah Muthmainnah , Suyono Suyono , Ainur Avin 
Published: July 2018

<p class="abstrak">A chemometric-based electronic nose has designed for analyzing pork oil and olive oil using the odor pattern classifications. The electronic nose (e-nose) built from a combination of several chemical sensors derived from a semiconductor. The data retrieval was done by vaporizing the sample, then being captured by the sensor and identified by the electronic nose (e-nose). The output data from the electronic nose is the voltage released by each sensor. The analyzed samples were 100% olive oil, 100% pork oil and a combination of olive oil and pork oil with a ratio of 50%: 50%. The result of pattern classification using linear discriminant analysis (LDA) method shows that each sample is clustered well with the percentage of first discriminant function value is 87,9% and second discriminant function is 12,1%.</p>
Análise da Revisão Cochrane: Alta Hospitalar Precoce para Hospitalização Domiciliária. Cochrane Database Syst Rev. 2017;6:CD000356.
Authors: Alves Mariana , Vieira Miguel Bigotte , Costa João , Carneiro António Vaz 
Published: July 2018

A hospitalização domiciliária é um serviço que proporciona tratamento a doentes com doença aguda no próprio domicílio, os quais noutras condições necessitariam de internamento hospitalar em enfermaria de agudos. No entanto, o benefício clínico desta intervenção e o seu efeito nos custos em saúde não se encontram estabelecidos. Esta revisão sistemática Cochrane teve como objectivo avaliar a eficácia e custos associados aos cuidados de doentes admitidos no serviço de hospitalização domiciliária em comparação com internamento hospitalar habitual. Foi realizada revisão sistemática da literatura através de pesquisa nas seguintes bases de dados - The Cochrane Effective Practice and Organisation of Care Group (EPOC) register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, CINAHL, e EconLit - até 9 de janeiro de 2017. Foram incluídos 32 ensaios clínicos aleatorizados (2 dos quais não publicados), incluindo 4746 doentes. A presente revisão detetou evidência insuficiente do benefício económico (através de uma redução no período de internamento hospitalar) ou melhoria dos resultados clínicos da hospitalização domiciliária.
KEEFEKTIFAN METODE BILINGUAL INTENSIF UNTUK KEMAMPUAN MEMBACA DAN MENULIS PADA PENDIDIKAN KEAKSARAAN MASYARAKAT SAMIN BLORA
Authors: Hapsari Melati Indri , Hadi Sanoto 
Published: July 2018

This research aimed to know if in Samin community reading and writing skills of literacy education participants taught with intensive bilingual method are better than those taught with SAS method. The research conducted in Tanduran Village Blora Regency in 2010, involved 40 research subjects comprising 20 subjects for experimental group with intensive bilingual method and 20 subjects with SAS method for controlling group. The data obtained were analyzed in two stages i.e. in the preliminary analysis and in hypothesis testing. The result of the research indicates, the reading and writing skills of literacy education participants in Samin community taught with intensive bilingual method are better than those taught wit SAS method.
PENGEMBANGAN MODEL PENDIDIKAN LIFE SKILLS BERBASIS KEWIRAUSAHAAN MELALUI EXPERIENTIAL LEARNING
Authors: Prasetyo Iis , Tohani Entoh , Sumarno Sumarno 
Published: July 2018

The existing life skill education program is not effective to reduce community poverty as the program just focus on producing more community hardskills than community softskills. This research aimed to create a model of entrepreneurship based 4-H lifeskills to decrease rural poverty. This research was conducted as from May through November 2013, in three regions of Gunung Kidul, Special Region of Yogyakarta. The data were collected by interview, documentation, observation and questionaire then analysed qualitatively and quantitatively. Research result shows: (1) most of the target research group members have dificulties in implementing several skills they obtained in the previous training; (2) the 4-H lifeskills model designed on the basis of empirical community condition is able to optimalize the use of the target group member resources; and (3) the model testing shows all of the three target groups have increasing mean of 4-H lifeskills perception. It means the model 4-H developed by researcher are effective.
EXPLORING STRATEGIES TO ENHANCE ISLAMIC BANKING’S ROLE TO RAISE CASH WAQF FUNDS
Authors: Khairunisa Rizanti , Akbar Nashr , Devi Abrista 
Published: July 2018

<p>Cash Waqf funds has an important role to empower the <br />economy of Ummah. Unfortunately, the collected cash<br />waqf fund is still very small compared to its potential<br />number. Against this background, this research<br />aims to design systems that may enchance the role of<br />Islamic banks in cash waqf fund raising. This paper<br />employed Interpretative Structural Modeling (ISM) by<br />conducting literature studies and In-depth interviews<br />with some regulators, practitioners and academicians.<br />The result shows that experts and practitioners agreed<br />that the strong legal support on cash waqf is necessary<br />to enhance the role of Islamic Banks to raise cash waqf<br />funds. It creates a sense of secure to the stakeholders.<br />Furthermore, it requires a strong coordination between<br />Indonesian Waqf Board (BWI), Ministry of Religious<br />Affairs, Bank Indonesia (BI), Financial Services<br />Authority (OJK), Nazhir and Islamic Financial<br />Institutions that may receive cash waqf (LKS-PWU)<br />in order to boost the role of Islamic Banks. The main<br />obstacle that must be tacled soon is the lack of education<br />about cash waqf. </p>
Functional Status of Women and Their Partners After Childbirth
Authors: ÖZKAN Sevgi , Göral Türkcü Sinem , Kayhan Özlem , Serçekuş Ak Pınar , Sevil Ümran 
Published: July 2018

The aim of
this study is to define the changes within the social dimension of the
functional status of women and their partners in the months following the birth
of their child.
A total of 90 participants were included in the study
(45 women and 45 partners). Data were collected in two steps via face-to-face
interviews. The first step involved administration of a personal information
form and the functional status inventories to the women and their partners
between the postpartum sixth and eighth weeks. The second step involved
re-administration of the same functional status inventories to the women and
their partners in the postpartum sixth month. Results from the examination of the functional
status of the women and their partners in the postpartum second and sixth
months showed that there was a significant increase in the areas of household
activities (p=0,000), social and community activities (p=0,000) and self-care
activities (p=0,000) for the women in the sixth month; similarly, for the
fathers, household activities (p=0,008),
social and community activities (p=0,003) and child care activities (p=0,007)
rose in the sixth month. Furthermore, the study found that certain sociodemographic
variables had an effect on functional status (p=0,000). It is important that nurses and/or
midwives support parents during the pregnancy process, particularly during the
transition into their new roles as women and their partners, and help prepare them
for the changes to occur as they enter into this new period of life.
Effect of Dietary Probiotics(Saccharomyces cerevisae)Supplementation on Serum Biochemicals ofTrypanosoma brucei bruceiInfected Rats
Authors: Eze James I. , Didacus Ubochioma E. 
Published: July 2018

Background:Trypanosomosis is an important disease of both humans and animals commonly found in most parts of Africa and South America. Because of their activities, the parasites produce numerous changes in the cellular and biochemical constituents of blood. Also, trypanosomosis cause immunosuppression and also induce lipid peroxidation in the host. Probiotics confer beneficial health benefit to the host such as immune stimulation, protection against pathogens, metabolism, reduced oxidative stress, etc.Methods:Thirty (30) adult albino rats were assigned into 5 groups (A – E) of 6 rats each. Groups A, B and C rats were fed feed supplemented with probiotics at 0.08, 0.12 and 0.16 mg per kg respectively. On day 14 on the supplementation (OTS), groups A, B, C and D rats were infected with 1 x 106 trypanosomes intraperitonealy. Group E served as the not infected, not supplemented control.Results:The pre-infection supplementation did not vary the serum alanine transaminase (ALT), aspartrate transaminase (AST), urea, creatinine and total protein values of groups A, B and C. However, following infection, the ALT value of group D (infected, not supplemented) was significantly (p<0.05) higher than other groups on day 42 OTS. Also, the AST value of groups A and D were significantly (p<0.05) higher than group E but not with groups B and C on days 42 and 56 on the supplementation. On day 28 OTS, the urea level of group B was significantly (p<0.05) lower than group D whereas on days 42 and 56, group E and groups E and C were significantly (p<0.05) lower than other groups respectively. The serum creatinine level showed increase following infection with groups A and D being significantly (p<0.05) higher than other groups on days 42 and 56 OTS. On day 28 OTS, the total protein value of group A was significantly (p<0.05) lower than group C but not with other groups. By days 42 and 56 OTS, group D showed significantly (p<0.05) lower protein level when compared with other groups. The mean parasitaemia level of group D was significantly higher than other infected infected groups on days 28 and 42 on the supplementation. However, on day 56, the parasitaemia level of all infected groups did not vary (p>0.05).Conclusion:The ability of the supplementation to keep serum biochemical values before infection within range, and the subsequent maintenance of the value during most part of the infection were indication that probiotic was not toxic and may play a vital role in management of trypanosomosis.
One-Pot Synthesis of Triazolo-Heterolignans: Biological Evaluation and Molecular Docking Studies as Tubulin Inhibitors
Authors: Reddy Chada Raji , Subbarao Muppidi , Vijaykumar Jonnalagadda , Jadav Surender Singh , Sasane Nilesh , Valleti Reddi Rani , Supriya Bhukya , Ummanni Ramesh 
Published: July 2018

Background:
The anti-mitotic activity of podophyllotoxin derivative targeting tubulin enzyme
proved them as strong polymerization inhibitors. The introduction of heteroatom along with different heteroaryl
systems in naturally obtained lignans created a latitude for design of bioactive components. A novel one-pot
sequential propargylation/cycloaddition reaction strategy has been followed to synthesize triazolo-heterolignans.

Objective:
To screen anti-proliferative activity of novel heterolignans and to determine their mode of action.

Method:
SRB assay, Cytotoxicity evaluation, PI uptake for analysis of cell cycle, caspase-3 activity, Western
blot analysis and Immunofluorescence and molecular docking studies.

Results:
SRB assay of synthesised compounds were provided compound 3a and 5f to be highly active among
the synthesized compounds. The Compound 3a showed cell cycle arrest at G2/M phase and 5f arrest the cells at
G1 phase. Compound 5f displayed caspase 3 mediated apoptotic effect at lower levels. Compound 3a and 5f
displayed microtubule disassembly inhibition same as paclitaxel and found to be occupying colchicine binding
site of tubulin, both ligands were depicted π-cation interaction with Lys352 residue and triazole ring accommodated
at the lactone binding site.

Conclusion:
A novel one-pot sequential propargylation/cycloaddition reaction has been developed for the synthesis
of triazolo-heterolignans. Compound 3a and 5f were displayed good cytotoxic activities and found to
inhibit microtubule disassembly. The importance of triazole ring of heterolignans has been studied by molecular
docking experiments and results were compared.