bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curation of a Simulation Experience by the Clinical Scholar: An Educational Technique in Postprofessional Athletic Training
Authors: Winkelmann Zachary K. , Eberman Lindsey E. , Edler Jessica R. , Livingston Laura B. , Games Kenneth E. 
Published: June 2018

Context:
Postprofessional athletic training programs continue to prepare advanced-practice leaders in the profession. As part of being leaders and clinical scholars within the field, it is important that students pursing postprofessional graduate education be exposed to curriculum and instructional theory, practice, and strategies.

Objective:
To describe an education technique focused on the curation of a simulation assignment as part of a postprofessional athletic training course as a means to develop an appreciation of instructional strategies as a clinical scholar.

Background:
The postprofessional athletic training student (PP-ATS) may be working as a full-time clinician, graduate assistant, or novice educator, or as an intern within an athletic training clinic. Regardless of employment status, PP-ATSs engage with several key stakeholders, ranging from parents and legal guardians to coaching staff and professional athletic training students. The PP-ATS may be tasked to provide education to these stakeholders in the form of patient participation status to a coach, describing the pathogenesis of a condition to a patient, and rationale for care to professional athletic training students.

Description:
The PP-ATSs were placed in learning communities of 3 to 5 students. The learning communities were tasked with the development of high- and low-fidelity simulations for learners (the other PP-ATSs in the course) to engage in during an intensive and focused learning session, facilitation of the experience, and a debrief encounter.

Clinical Advantage(s):
A 2-fold benefit exists. First, PP-ATSs are engaged in the design and development of a simulation experience as an instructional intervention. Second, simulation learners are gainfully engaged in low-stakes patient encounters that promote professional growth.

Conclusion(s):
Developing and implementing learner-curated simulation experiences exposes PP-ATSs to an innovative instructional strategy in athletic training.
PROPOSTA DE GESTÃO DE ESTOQUES PARA ATACADO: UM ESTUDO DE CASO
Authors: Schuster Ajala Roberto , Giordani Rodrigo 
Published: June 2018

O presente artigo baseia-se e um estudo sobre gestão de estoques em uma empresa atacadista, que atua na comercialização e distribuição de produtos alimentícios, higiene e limpeza, localizada no município de Cerro Largo - RS. O objetivo deste estudo foi elaborar uma proposta de gestão de estoque, baseando-se no espaço físico da organização e no agrupamento de mercadorias. A metodologia empregada neste estudo foi de natureza aplicada, quanto ao objetivo exploratória e sua estratégia baseia-se em um estudo de caso. Este estudo contribuiu para que a organização reveja seus conceitos de estocagem, leiaute, endereçamento e outros fatores que afetam de forma direta e indiretamente nos processos de organização e controle dos estoques. O estudo sobre a gestão de estoques para a organização foi de suma importância e fez com que a mesma tenha um melhor aproveitamento do seu espaço físico, que hoje é considerado um permanente desafio da logística interna em muitas empresas. A partir deste estudo, organização possou a contar com uma importante ferramenta de gestão de estoques, que poderá auxiliar na tomada de decisões sobre o mesmo.
Lambl’s excrescences and a review of therapeutic strategies
Authors: Osorio Benedict , Hou Linle , Xu Jack , Pagan Eric , Piscopiello Michael 
Published: June 2018

Background: Lambl’s excrescences (LEx) are thin, filiform structures that arise on the lines of closure of heart valves. Although rare, we have come across various case reports in the literature describing thromboembolic events associated with LEx. We report the case of a 63-year-old female who presented with TIA-like symptoms and was found to have a LEx on the aortic side of native aortic valve. We conducted a comprehensive literature review with emphasis on different therapeutic strategies utilized to provide insight for future encounters.Case presentation: A 63-year-old female with a past medical history significant for hypertension and hyperlipidemia presented to the emergency room with symptoms of dysarthria and unsteady gait. While in the hospital, the patient returned to her baseline gait and speech without intervention. Work-up for including computed tomography of the head, magnetic resonance imaging, and carotid doppler, as well as prolonged telemetry monitoring was negative. A transthoracic echocardiogram showed a 0.81 cm linear echodensity attached to the aortic side of the aortic valve, highly suggestive of LEx that was later confirmed on transesophageal echocardiogram. Patient was placed on clopidogrel alone for antiplatelet therapy due to an aspirin allergy and she was subsequently discharged home.Discussion: No standard management for LEx currently exists. We aim to add to the evidence of effective management and explore the literature of patients who have experienced TIA/CVA symptoms secondary to LEx.
Immunohistochemical Expression of p16 in Melanocytic Lesions: An Updated Review and Meta-analysis
Authors: Koh Stephen S. , Cassarino David S. 
Published: June 2018

Context.—Making an accurate diagnosis for melanocytic lesions has always been challenging for pathologists, especially when dealing with difficult-to-diagnose cases. Misdiagnosis of melanoma and melanocytic lesions in general has tremendous medical-legal implications, often leading to unnecessary and excessive use of adjunctive tests. Although molecular testing is of much interest and there is great support for its development, currently, for most melanocytic lesions, immunohistochemical studies remain the most practical method for assistance in the routine diagnosis of melanocytic lesions for the average pathologist.Objectives.—To review the practical use of p16 immunohistochemistry for evaluating melanocytic lesions, particularly for differentiating benign from malignant tumors, and to perform a meta-analysis of primary studies evaluating p16 immunohistochemistry in melanocytic lesions.Data Sources.—A PubMed database search for literature reporting melanocytic lesions and p16 immunohistochemistry was performed. Essential information from each study (number of samples, antibody used, collection dates, overall p16 immunohistochemistry results, and general method of interpretation) was tabulated and analyzed. Examples of representative cases showing p16 immunostaining pattern are also illustrated.Conclusions.—Incorporation of p16 immunohistochemistry for the diagnosis of melanocytic lesions is of limited use, especially for the purpose of differentiating benign from malignant lesions. Evaluation of multiple studies reveals a wide range of results. However, there appears to be some value for the use of p16 in distinguishing nodal nevi from metastatic melanoma within nodes. The method of interpretation (nuclear versus cytoplasmic staining) also appears to give differing results, as studies considering only nuclear staining appeared to show more consistent results from study to study.
A theory and methodology to quantify knowledge
Authors: Fanelli Daniele 
Published: June 2018

This article proposes quantitative answers to meta-scientific questions including "how much knowledge is attained by a research field?","how rapidly is a field making progress?", "what is the expected reproducibility of a result?", "how much knowledge is lost from scientific bias and misconduct?" "what do we mean by soft science?", "what demarcates a pseudoscience?".
Knowledge is suggested to be a system-specific property measured by K, a quantity determined by how much the information contained in an explanandum is compressed by an explanans, which is composed of an information "input" and a "theory/methodology" conditioning factor. The three arguments of the K function are quantifiable using methods of classic and algorithmic information theory. This approach is justified on three grounds: 1) K results from postulating that information is finite and knowledge is information compression; 2) K is compatible and convertible to ordinary measures of effect size and algorithmic complexity; 3) K is physically interpretable as a measure of entropic efficiency. Moreover, the K function has useful properties that support its potential as a measure of knowledge.
Examples from a variety of fields are given to illustrate the possible uses of K. These examples include quantifying: the knowledge value of proving Fermat's last theorem; the accuracy of measurements of the electron's mass; the half life of eclipse predictions; the usefulness of evolutionary models of reproductive skew; the significance of gender differences in personality; the sources of irreproducibility in psychology; the impact of scientific misconduct and QRP; the knowledge value of astrology. Furthermore, a cumulative K may complement ordinary meta-analysis and may give rise to a universal classification of sciences and pseudosciences.
Simple and memorable mathematical formulae summarize the theory's key results and implications. In addition to practical uses in meta-research, these formulae may have conceptual applications in philosophy and in research policy, and may guide scientists to make progress on all frontiers of knowledge.
PENGETAHUAN DAN MOTIVASI PERAWAT BERPERAN PENTING DALAM MENGATASI MASALAH TIDUR DI RUMAH SAKIT
Authors: Nuramalia Lia , Kuntarti Kuntarti 
Published: June 2018

Perawat memiliki peran penting dalam mengatasi masalah tidur pasien melalui pemberian intervensi keperawatan. Penelitian ini bertujuan untuk mengidentifikasi faktor yang berhubungan dengan penerapan intervensi keperawatan untuk mengatasi masalah tidur. Desain penelitian yang digunakan adalah analitik korelasi dengan pendekatan cross sectional dan teknik proportional random sampling. Penelitian ini melibatkan 99 perawat di instalasi rawat inap di salah satu rumah sakit di Jakarta. Data dianalisis dengan uji Chi-square. Hasil penelitian menunjukkan terdapat hubungan antara pengetahuan dan motivasi perawat dengan penerapan intervensi keperawatan (berturut-turut p= 0,022, p= 0,012; α= 0,05). Sebanyak 53,5% perawat belum mengatasi masalah tidur pasien dengan baik. Pengetahuan dan motivasi perawat perlu ditingkatkan melalui pelatihan yang terintegrasi dengan topik keamanan pasien. Kata kunci: intervensi keperawatan, masalah tidur, motivasi, pengetahuan, perawat Knowledge and Motivation of Nurses Important in the Implementation of Nursing Intervention to Overcome Sleep Problems in Hospital. Nurses have an important role in addressing hospitalized patients’ sleeping disorder. This study aimed to identify factors associated with nursing interventions to overcome sleeping disorder in inpatient unit of one hospital in Jakarta. This study applied correlative-analytical with cross sectional design approach. There were 99 nurses recruited by proportional random sampling. Data was analyzed using chi square test method. Results showed that there were correlation between knowledge and motivation with implementation of nursing interventions for sleeping disorder (successively p= 0.022, p= 0.012; α= 0.05). There were 53.5% of the nurses that were unable to provide the intervention well. The nurses’ knowledge and motivation need to be improved by integrated training of patient safety. Keywords: knowledge, nursing intervention, sleep disorder, motivation, nurse
DEPRESI BERHUBUNGAN DENGAN KUALITAS HIDUP LANSIA DI PANTI SOSIAL TRESNA WERDHA DI JAKARTA
Authors: Puspadewi A.A. Ayu Rani , Rekawati Etty 
Published: June 2018

Setiap orang dapat mengalami depresi, salah satunya adalah lansia, dimana lansia memiliki konsekuensi fungsional yang lebih serius dibandingkan dengan tingkat pertumbuhan lainnya, mulai dari kualitas hidup yang negatif hingga bunuh diri. Tujuan penelitian adalah untuk mengetahui hubungan antara depresi dengan kualitas hidup lansia. Sampel penelitian adalah lansia ≥ 60 tahun yang tinggal di Panti Sosial Tresna Werdha Budi Mulia 1 Jakarta, mampu berkomunikasi dengan bahasa Indonesia, serta bersedia menjadi responden. Jenis penelitian ini menggunakan desain penelitian cross sectional dengan metode simple random sampling yang melibatkan 101 lansia. Hasil penelitian menunjukkan adanya hubungan antara tingkat depresi dengan kualitas hidup lansia (p=0,017; α=0,10). Penelitian ini diharapkan dapat berguna untuk pengembangan ilmu keperawatan di masa yang akan datang terkait peningkatan kualitas hidup lansia dengan cara menangani depresi lansia. Kata Kunci: Depresi, Kualitas Hidup, Lansia, Panti Sosial Tresna Werdha Abstract Depression in Relation with the Quality of Life Elderly in Nursing Home Jakarta. Depression could experienced by anyone, such as elderly whose fuctional consequences is experienced more serious such as low quality of life and the worst one is suicidal. The purpose of this research was to find the relationship between depression and quality of life in elderly. The research sample was elderly aged 60 and over who live at Institutionof Elderly Budi Mulia 01 Jakarta, speak Bahasa, and willing to be a respondent. This research used cross sectional study design with simple random sampling method which involved 101 elderly. The result of this study showed that there was significant relation between level of depression and quality of life in elderly (p=0.017; α=0.10). This research is expected to be useful for nursing science development in the future, spesificly on preventive of quality of life decreased by handling depression in elderly. Keywords: Depression, quality of life, elderly, nursing homes
Lymphatic Pump Treatment Mobilizes Bioactive Lymph That Suppresses Macrophage Activity In Vitro
Authors: Castillo Rudy , Schander Artur , Hodge Lisa M. 
Published: June 2018

Abstract

Context
By promoting the recirculation of tissue fluid, the lymphatic system preserves tissue health, aids in the absorption of gastrointestinal lipids, and supports immune surveillance. Failure of the lymphatic system has been implicated in the pathogenesis of several infectious and inflammatory diseases. Thus, interventions that enhance lymphatic circulation, such as osteopathic lymphatic pump treatment (LPT), should aid in the management of these diseases.

Objective
To determine whether thoracic duct lymph (TDL) mobilized during LPT would alter the function of macrophages in vitro.

Methods
The thoracic ducts of 6 mongrel dogs were cannulated, and TDL samples were collected before (baseline), during, and 10 minutes after LPT. Thoracic duct lymph flow was measured, and TDL samples were analyzed for protein concentration. To measure the effect of TDL on macrophage activity, RAW 264.7 macrophages were cultured for 1 hour to acclimate. After 1 hour, cell-free TDL collected at baseline, during LPT, and after TDL was added at 5% total volume per well and co-cultured with or without 500 ng per well of lipopolysaccharide (LPS) for 24 hours. As a control for the addition of 5% TDL, macrophages were cultured with phosphate-buffered saline (PBS) at 5% total volume per well and co-cultured with or without 500 ng per well of LPS for 24 hours. After culture, cell-free supernatants were assayed for nitrite (NO2
−), tumor necrosis factor α (TNF-α) and interleukin 10 (IL-10). Macrophage viability was measured using flow cytometry.

Results
Lymphatic pump treatment significantly increased TDL flow and the flux of protein in TDL (P<.001). After culture, macrophage viability was approximately 90%. During activation with LPS, baseline TDL, TDL during LPT, and TDL after LPT significantly decreased the production of NO2
−, TNF-α, and IL-10 by macrophages (P<.05). However, no significant differences were found in viability or the production of NO2
−, TNF-α, or IL-10 between macrophages cultured with LPS plus TDL taken before, during, and after LPT (P>.05).

Conclusion
The redistribution of protective lymph during LPT may provide scientific rationale for the clinical use of LPT to reduce inflammation and manage edema.
Effects of temperature and salinity stress on DNA methylation in a highly invasive marine invertebrate, the colonial ascidianDidemnum vexillum
Authors: Hawes Nicola A. , Tremblay Louis A. , Pochon Xavier , Dunphy Brendon , Fidler Andrew E. , Smith Kirsty F. 
Published: June 2018

Environmentally induced epigenetic changes may contribute to phenotypic plasticity, increase adaptive potential in changing environments, and play a key role in the establishment and spread of invasive species in new habitats. In this study, we used methylation-sensitive amplified polymorphism (MSAP) to assess environmentally induced DNA methylation changes in a globally invasive clonal ascidian,Didemnum vexillum. We tested the effect of increasing temperature (19, 25 and 27 °C) and decreasing salinity (34, 32, 30, 28 and 26 practical salinity units (PSU)) on global DNA methylation, growth and survival rates. Exposure to 27 °C resulted in significant changes in DNA methylation over time. Growth also decreased in colonies exposed to high temperatures, suggesting they were under thermal stress. In contrast, no differences in growth nor DNA methylation patterns were observed in colonies exposed to a decreasing salinity gradient, potentially due to prior adaptation. The results of this study show that environmental stress can induce significant global DNA methylation changes in an invasive marine invertebrate on very rapid timescales, and that this response varies depending on the type, magnitude, and duration of the stressor. Changes in genomic DNA methylation and the rate of growth may act to ‘buy survival time’ under stressful conditions, expanding the distribution limits of this globally invasive species.
Forecasting influenza epidemics by integrating internet search queries and traditional surveillance data with the support vector machine regression model in Liaoning, from 2011 to 2015
Authors: Liang Feng , Guan Peng , Wu Wei , Huang Desheng 
Published: June 2018

Background
Influenza epidemics pose significant social and economic challenges in China. Internet search query data have been identified as a valuable source for the detection of emerging influenza epidemics. However, the selection of the search queries and the adoption of prediction methods are crucial challenges when it comes to improving predictions. The purpose of this study was to explore the application of the Support Vector Machine (SVM) regression model in merging search engine query data and traditional influenza data.

Methods
The official monthly reported number of influenza cases in Liaoning province in China was acquired from the China National Scientific Data Center for Public Health from January 2011 to December 2015. Based on Baidu Index, a publicly available search engine database, search queries potentially related to influenza over the corresponding period were identified. An SVM regression model was built to be used for predictions, and the choice of three parameters (C, γ, ε) in the SVM regression model was determined by leave-one-out cross-validation (LOOCV) during the model construction process. The model’s performance was evaluated by the evaluation metrics including Root Mean Square Error, Root Mean Square Percentage Error and Mean Absolute Percentage Error.

Results
In total, 17 search queries related to influenza were generated through the initial query selection approach and were adopted to construct the SVM regression model, including nine queries in the same month, three queries at a lag of one month, one query at a lag of two months and four queries at a lag of three months. The SVM model performed well when with the parameters (C = 2, γ = 0.005, ɛ = 0.0001), based on the ensemble data integrating the influenza surveillance data and Baidu search query data.

Conclusions
The results demonstrated the feasibility of using internet search engine query data as the complementary data source for influenza surveillance and the efficiency of SVM regression model in tracking the influenza epidemics in Liaoning.
Revealing the Mechanics of Helicoidal Composites through Additive Manufacturing and Beetle Developmental Stage Analysis
Authors: Zaheri Alireza , Fenner Joel S. , Russell Benjamin P. , Restrepo David , Daly Matthew , Wang Di , Hayashi Cheryl , Meyers Marc A. , Zavattieri Pablo D. , Espinosa Horacio D. 
Published: June 2018

AbstractInvestigation into the microstructure of high performance natural materials has revealed common patterns that are pervasive across animal species. For example, the helicoid motif has gained significant interest in the biomaterials community, where recent studies have highlighted its role in enabling damage tolerance in a diverse set of animals. Moreover, the helicoid motif corresponds to a highly adaptable architecture where the control of the pitch rotation angle between fibrous structures produces large changes in its mechanical response. Nature, takes advantage of this special feature enabling an active response to particular biological needs occurring during an animal's ontogeny. In this work, we demonstrate this adaptive behavior in helicoidal architectures by performing a mechanistic analysis of the changes occurring in the cuticle of the figeater beetle (Cotinis mutabilis) during its life cycle. We complement our investigation of the beetle with the testing of 3D printing samples and a systematic analysis of the effect of pitch angle in the inherent mechanics of helicoidal architectures. Experimentation and analysis reveal improved isotropy and enhanced toughness at lower pitch angles, highlighting the flexibility of the helicoidal architecture. Moreover, trends in stiffness measurements were found to be well‐predicted by laminate theory, suggesting facile mechanics laws for use in biomimicry.
Bioinspired Mineral–Organic Bioresorbable Bone Adhesive
Authors: Kirillova Alina , Kelly Cambre , von Windheim Natalia , Gall Ken 
Published: June 2018

AbstractBioresorbable bone adhesives have potential to revolutionize the clinical treatment of the human skeletal system, ranging from the fixation and osteointegration of permanent implants to the direct healing and fusion of bones without permanent fixation hardware. Despite an unmet need, there are currently no bone adhesives in clinical use that provide a strong enough bond to wet bone while possessing good osteointegration and bioresorbability. Inspired by the sandcastle worm that creates a protective tubular shell around its body using a proteinaceous adhesive, a novel bone adhesive is introduced, based on tetracalcium phosphate and phosphoserine, that cures in minutes in an aqueous environment and provides high bone‐to‐bone adhesive strength. The new material is measured to be 10 times more adhesive than bioresorbable calcium phosphate cement and 7.5 times more adhesive than non‐resorbable poly(methyl methacrylate) bone cement, both of which are standard of care in the clinic today. The bone adhesive also demonstrates chemical adhesion to titanium approximately twice that of its adhesion to bone, unlocking the potential for adherence to metallic implants during surrounding bony incorporation. Finally, the bone adhesive is shown to demonstrate osteointegration and bioresorbability over a 52‐week period in a critically sized distal femur defect in rabbits.