bluuebunny/crossref_metadata_2025_split huggingface dataset:
The h‐SbxWO3+2x Oxygen Excess Antimony Tungsten Bronze
Authors: von Rohr Fabian O. , Ryser Alice , Ji Huiwen , Stolze Karoline , Tao Jing , Frick Jessica J. , Patzke Greta R. , Cava Robert J. 
Published: January 2019

AbstractWe describe the previously unreported oxygen excess hexagonal antimony tungsten bronze with composition Sb0.5W3O10, in the following denoted as h‐SbxWO3+2x with x=0.167, to demonstrate its analogy to classical AxWO3 tungsten bronzes. This compound forms in a relatively narrow temperature range between 580 °C<T<620 °C. It was obtained as a dark‐blue polycrystalline powder, and as thin, needle‐shaped, blue single crystals. h‐SbxWO3+2x crystallizes in the hexagonal space group P6/mmm with the cell parameters a=7.4369(4) Å and c=3.7800(2) Å. The antimony and excess oxygen occupy the hexagonal channels within the network of corner‐sharing WO6 octahedra. h‐SbxWO3+2x has a resistivity of ρ300 K≈1.28 mΩ cm at room temperature, with little if any temperature‐dependence on cooling. DFT calculations on a simplified model for this compound find a metallic‐like electronic structure with the Fermi level falling within rather flat bands, especially around the Γ point.
FeOOH Nanocubes Anchored on Carbon Ribbons for Use in Li/O2 Batteries
Authors: Lin Zhipeng , Zhang Hao , Liang Guofeng , Jin Yanqi , Zeng Hongbin , Li Jiawang , Chen Jian , Zhang Weihong , Xie Fangyan , Jin Yanshuo , Meng Hui 
Published: January 2019

AbstractA composite of FeOOH nanocubes anchored on carbon ribbons has been synthesized and used as a cathode material for Li/O2 batteries. Fe2+ ion‐exchanged resin serves as a precursor for both FeOOH nanocubes and carbon ribbons, which are formed simultaneously. The as‐prepared FeOOH cubes are proposed to have a core–shell structure, with FeOOH as the shell and Prussian blue as the core, based on information from XPS, TEM, and EDS mapping. As a cathode material for Li/O2 batteries, FeOOH delivers a specific capacity of 14816 mA h g−1cathode with a cycling stability of 67 cycles over 400 h. The high performance is related to the low overpotential of the oxygen reduction/evolution reaction on FeOOH. The cube structure, the supporting carbon ribbons, and the ‐OOH moieties all contribute to the low overpotential. The discharge product Li2O2 can be efficiently decomposed in the FeOOH cathode after a charging process, leading to higher cycling stability. Its high activity and stability make FeOOH a good candidate for use in non‐aqueous Li/O2 batteries.
Synthesis of Porous Fe3C‐Based Composite Beads as Heterogeneous Oxidation Catalysts
Authors: Wang Zhe , Jiang Yanqiu , Li Yudong , Huo Hang , Zhao Tingting , Li Defeng , Lin Kaifeng , Xu Xianzhu 
Published: January 2019

AbstractA series of multiscale cementite/iron/porous carbon (CIPC‐T) composites with extremely low nitrogen content and millimeter‐size spherical morphology were prepared by simple carbothermal pyrolysis of resin spheres exchanged with ferric oxalate anions. CIPC‐T materials are composed of highly disperse core–shell‐structured Fe3C/Fe@graphitic carbon (CI@GC) nanoparticles embedded in a porous amorphous carbon framework. A mechanism for the formation of the composites is proposed on the basis of the results of XRD, SEM, TEM, and thermogravimetric analysis. The Fe3C content can be easily controlled just by using different carbothermal temperatures. The CIPC‐T materials proved to be active as heterogeneous catalysts for oxidation of ethylbenzene to acetophenone and Fenton‐like oxidation of methylene blue. For the first time, the role of Fe3C in catalytic oxidation was confirmed. The spherical morphology of the composites and magnetic property facilitate separation of the catalyst from the reaction solution. More importantly, no leaching of iron active sites occurs during the reactions and the catalyst can be reused in continuous runs without obvious loss of activity. Such high stability of iron sites in the composites is ascribed to the protecting outer graphitic carbon shell of CI@GC.
Palladium‐Catalyzed Carbo‐Oxygenation of Propargylic Amines using in Situ Tether Formation
Authors: Greenwood Phillip D. G. , Grenet Erwann , Waser Jerome 
Published: January 2019

Abstract1,2‐Amino alcohols and α‐aminocarbonyls are frequently found in natural products, drugs, chiral auxiliaries, and catalysts. This work reports a new method for the palladium‐catalyzed oxyalkynylation and oxyarylation of propargylic amines. The reaction is perfectly regioselective based on the in situ introduction of a hemiacetal tether derived from trifluoroacetaldehyde. cis‐Selective carbo‐oxygenation was achieved for terminal alkynes, whereas internal alkynes gave trans‐carbo‐oxygenation products. The obtained enol ethers could be easily transformed into 1,2‐amino alcohols or α‐amino ketones using hydrogenation or hydrolysis, respectively.
Visible‐Light‐Driven C−H Oxidation of Cyclic Tertiary Amines: Access to Synthetic Strychnos Alkaloids with Antiviral Activity
Authors: Guryev Anton A. , Hahn Friedrich , Marschall Manfred , Tsogoeva Svetlana B. 
Published: January 2019

AbstractAir and visible light have been used in facile direct C−H oxidation of cyclic tertiary amines at ambient conditions, employing organic dyes as photocatalysts and LED. Tolerance of this new environmentally compatible protocol to various side‐chain derivatizations of tryptoline and tetrahydroisoquinoline substrates was demonstrated. The developed method provides a straightforward and sustainable route towards δ‐lactams, which feature strong antiviral properties (EC50 down to 4.6±1.8 μm) against human cytomegalovirus (HCMV). The clear advantages, which are easily available and inexpensive reagents, organic dyes, visible light, air/O2 and atom efficiency, make this system highly appealing for synthesis of versatile Strychnocarpine alkaloid derivatives with antiviral activity.
Data Exchange for Process Engineering – Challenges and Opportunities
Authors: Fillinger Sandra , Esche Erik , Tolksdorf Gregor , Welscher Wolfgang , Wozny Günter , Repke Jens‐Uwe 
Published: January 2019

AbstractThe ideas and requirements for digitization in the process industry are manifold – the interoperability of the tools in use by engineers is an important prerequisite. The strong heterogeneity of existing data formats and standards as well as the variety of proprietary and company‐specific solutions confronts the process industry with huge challenges. This paper deals with the data exchange between process simulation, 2D CAD, and 3D CAD tools, provides an overview of existing standards and formats as well as initial experiences gained in a case study.
Bis‐Lactam Peptide [i, i + 4]‐Stapling
Authors: Hu Xiao , Wu Bo , Zheng Weiping 
Published: January 2019

Summary of main observation and conclusionEven though the bis‐lactam peptide stapling with the [i, i + 7] and the [i, i + 11] systems has been known to be able to afford % α‐helicity values up to 100% (25°C), the performance of the bis‐lactam peptide stapling with the [i, i + 4] system in current literature has been mediocre (% α‐helicity ≦40%, 25°C). In the current study, we found that high % α‐helicity is also obtainable with the bis‐lactam [i, i + 4]‐stapling by demonstrating with our model peptide sequence that the bis‐lactam [i, i + 4]‐stapling with Nε‐para‐phenylenediacetyl‐lysine was able to afford a % α‐helicity value of ~64.1% (25°C). Therefore, the bis‐lactam [i, i + 4]‐stapling could also be an efficacious peptide stapling mode that can be employed for biomedical applications.
A phase 1 trial of SGN‐CD70A in patients with CD70‐positive, metastatic renal cell carcinoma
Authors: Pal Sumanta K. , Forero‐Torres Andres , Thompson John A. , Morris John C. , Chhabra Saurabh , Hoimes Christopher J. , Vogelzang Nicholas J. , Boyd Thomas , Bergerot Paulo G. , Adashek Jacob J. , Li Hong , Yu Xuesong , Gartner Elaina M. , Carret Anne‐Sophie , Smith David C. 
Published: January 2019

BackgroundCluster of differentiation 70 (CD70) is frequently expressed in renal cell carcinoma (RCC) and has immunomodulatory properties. An antibody‐drug conjugate targeting CD70, SGN‐CD70A, was developed to treat patients with CD70‐positive RCC.MethodsThe objective of this phase 1, open‐label, dose‐escalation, multicenter study was to evaluate the safety and tolerability of SGN‐CD70A and establish its maximum tolerated dose in patients with CD70‐positive, metastatic RCC (mRCC). All subtypes of RCC were permitted, and no limit was set on the number of prior therapies. Safety assessments consisted of monitoring and recording all adverse events (AEs) and dose‐limiting toxicities (DLTs). Treatment response was assessed by radiographic tumor evaluation according to the Response Evaluation Criteria for Solid Tumors, version 1.1. A model‐based, modified continual‐reassessment method was used to estimate the probabilities of DLT and response.ResultsThe maximum tolerated dose was determined to be 30 μg/kg, with thrombocytopenia as the DLT. The most common AEs were fatigue (67%), anemia (61%), and thrombocytopenia (56%). Of 18 enrolled patients, 1 achieved a partial response and 13 achieved stable disease, for a clinical benefit rate of 78%. Limitations of the study included the heavily pretreated nature of patients, receipt of a median of 4 prior lines of therapy (range, 1‐8 prior lines of therapy), and diminishing response potential.ConclusionsThe modest antitumor activity of SGN‐CD70A does not support its development in mRCC. However, given the high disease control rate in a heavily pretreated population and the modest toxicity profile, CD70 remains of interest because of its immunomodulatory properties.
Distinct genome‐wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors
Authors: Tirosh Amit , Mukherjee Sanjit , Lack Justin , Gara Sudheer Kumar , Wang Sophie , Quezado Martha M. , Keutgen Xavier M. , Wu Xiaolin , Cam Maggie , Kumar Suresh , Patel Dhaval , Nilubol Naris , Tyagi Monica Varun , Kebebew Electron 
Published: January 2019

BackgroundAberrant methylation is a known cause of cancer initiation and/or progression. There are scant data on the genome‐wide methylation pattern of nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and sporadic and hereditary NFPanNETs.MethodsThirty‐three tissue samples were analyzed: they included samples from sporadic (n = 9), von Hippel‐Lindau (VHL)‐related (n = 10), and multiple endocrine neoplasia type 1 (MEN1)–related NFPanNETs (n = 10) as well as normal islet cells (n = 4) for comparison. Genome‐wide CpG methylation profiling was performed with the Infinium MethylationEPIC BeadChip assay and was analyzed with R‐based tools.ResultsIn unsupervised hierarchical clustering, sporadic and MEN1‐related NFPanNETs clustered together, and the VHL group was in a separate cluster. MEN1‐related NFPanNETs had a higher rate of hypermethylated CpG sites in comparison with sporadic and VHL‐related tumor groups. Differentially methylated region analysis confirmed the higher rate of hypermethylation in MEN1‐related tumors. Moreover, in an integrated analysis of gene expression data for the same tumor samples, downregulated gene expression was found in most genes that were hypermethylated. In a CpG island methylator phenotype analysis, 3 genes were identified and confirmed to have downregulated gene expression: secreted frizzle‐related protein 5 (SFRP5) in sporadic NFPanNETs and cell division cycle–associated 7‐like (CDCA7L) and RNA binding motif 47 (RBM47) in MEN1‐related NFPanNETs.ConclusionsMEN1 NFPanNETs have a higher rate of geno me‐wide hypermethylation than other NFPanNET subtypes. The similarity between the pathways enriched in a methylation analysis of known genes involved in NFPanNET tumorigenesis suggests a key role for aberrant methylation in the pathogenesis of NFPanNETs.
Simultaneous Targeted Methylation Sequencing (sTM‐Seq)
Authors: Asmus Natalie , Papale Ligia A. , Madrid Andy , Alisch Reid S. 
Published: January 2019

AbstractMapping patterns of DNA methylation throughout the epigenome are critical to our understanding of several important biological and regulatory functions, such as transcriptional regulation, genomic imprinting, and embryonic development. The development and rapid advancement of next‐generation sequencing (NGS) technologies have provided clinicians and researchers with accurate and reliable read‐outs of genomic and epigenomic information at the nucleotide level. Such improvements have significantly lowered the cost required for genome‐wide sequencing, facilitating the vast acquisition of data that has led to many improvements in patient care. However, the torrid rate of NGS data generation has left targeted validation approaches behind, including the confirmation of epigenetic marks such as DNA methylation. To overcome these shortcomings, we present a rapid and robust protocol for the parallel examination of multiple methylated sequences that we have termed simultaneous targeted methylation sequencing (sTM‐Seq). Key features of this technique include the elimination of the need for large amounts of high‐molecular weight DNA and the nucleotide specific distinction of both 5‐methylcytosine (5mC) and 5‐hydroxymethylcytosine (5hmC). Moreover, sTM‐Seq is scalable and can be used to investigate multiple loci in dozens of samples within a single sequencing run. By utilizing freely available web‐based software and universal primers for multipurpose barcoding, library preparation, and customized sequencing, sTM‐Seq is affordable, efficient, and widely applicable. Together, these features enable sTM‐Seq to have wide‐reaching clinical applications that will greatly improve turnaround rates for same‐day procedures and allow clinicians to collect high‐resolution data that can be used in a variety of patient settings. © 2019 by John Wiley & Sons, Inc.
Intramolecular Magnetic Interaction of Spin‐Delocalized Neutral Radicals through m‐Phenylene Spacers
Authors: Murata Tsuyoshi , Asakura Noriaki , Ukai Shusaku , Ueda Akira , Kanzaki Yuki , Sato Kazunobu , Takui Takeji , Morita Yasushi 
Published: January 2019

AbstractA new diradical having two 4,8,10‐trioxotriangulene (TOT) neutral radical units linked through an m‐phenylene moiety was synthesized and characterized by ESR measurements. An electrochemical study showed that the diradical undergoes two one‐electron reductions to generate corresponding dianion species, suggesting the electronic interaction between two TOT units through the π‐conjugated spacer. A strong intramolecular interaction between the two TOT units gives rise to the spin‐projected small hyperfine couplings in comparison with those of the monomer. Furthermore, the temperature dependent ESR measurement revealed that the dimer behaves as an S=1 species in the ground state with a ferromagnetic interaction of 2 J/kB=+7±3 K.
Transesterification of Isosorbide with Dimethyl Carbonate Catalyzed by Task‐Specific Ionic Liquids
Authors: Qian Wei , Tan Xin , Su Qian , Cheng Weiguo , Xu Fei , Dong Li , Zhang Suojiang 
Published: January 2019

AbstractGreen synthesis of high‐molecular‐weight isosorbide‐based polycarbonate (PIC) with excellent properties is a tremendous challenge and is profoundly influenced by the precursor. Herein, an ecofriendly catalyst was employed to obtain the more reactive PIC precursor dicarboxymethyl isosorbide (DC) with 99.0 % selectivity through the transesterification reaction of isosorbide with dimethyl carbonate. This is the indispensable stage of a one‐pot green synthesis of PIC, playing a critical role in giving an insight into the polymerization mechanism of polymer synthesis through the melt transesterification reaction. To this end, a series of 4‐substituted phenolate ionic liquids (ILs) were developed as a new type of high‐efficiency catalyst for this reaction. These homogeneous ILs exhibited outstanding catalytic performances. The DC selectivity increased gradually with decreasing IL basicity; among the ILs studied, trihexyl(tetradecyl)phosphonium 4‐iodophenolate ([P66614][4‐I‐Phen]) showed the highest catalytic activity. Additionally, according to the experimental results and DFT calculations, a plausible nucleophilic activation mechanism was proposed, which confirmed that the reaction is activated through the formation of H‐bonds and electrostatic interactions with the IL catalyst. This strategy of tunable basicity and structure of anions in ILs affords an opportunity to develop other ILs for the transesterification reaction, thereby conveniently providing a variety of polymers through a green synthetic pathway.
Supported Co–Re Bimetallic Catalysts with Different Structures as Efficient Catalysts for Hydrogenation of Citral
Authors: Di Xin , Lafaye Gwendoline , Especel Catherine , Epron Florence , Qi Ji , Li Chuang , Liang Changhai 
Published: January 2019

AbstractBimetallic Co–Re/TiO2 catalysts were developed for efficient citral hydrogenation. Bimetallic catalysts were prepared by co‐impregnation (CI), successive‐impregnation (SI), and surface redox method (SR). The arrangement between the Co and Re species on these systems was fully characterized using several techniques (TEM–energy‐dispersive X‐ray spectroscopy, H2 temperature‐programmed reduction, temperature‐programmed desorption, XRD, CO FTIR spectroscopy, model reaction of cyclohexane dehydrogenation), and their catalytic performances were evaluated for the selective hydrogenation of citral towards unsaturated alcohols. The Re and Co species are completely isolated in the CI sample, presenting a very limited Co–Re interaction. In SI samples, the metals coexist in a Janus‐type structure with a concentration of Re around Co. Decoration/core–shell structures are observed for SR samples resulting from the redox exchange between the metallic surface of the parent Co/TiO2 catalyst and the Re7+ species of the modifier precursor salt. The contact degree between the two metals gradually increases as follows: Isolated structure (CI)<Janus‐type structure(SI)<decoration/core–shell structure (SR). The unchanging structure of all SI samples independent of the Re loading leads to similar electron transfer, and the increase in Re content results in agglomeration of Re, thus decreasing the catalytic activity. Density‐of‐state (DOS) calculations prove that the high valence of Re is a disadvantage for the hydrogenation reaction. For SR samples, the increase of Re loading contributes to the electron transfer from Re to Co that is consistent with a change of structure from decoration to core–shell. The lack of directly accessible Co atoms for SR catalysts with fully coated structure decreases the efficiency of Re reduction. The presence of Co–Re interaction resulting from the close contact between metals plays a dominant role in the hydrogenation of citral. Nevertheless, an excessively high contact degree is unnecessary for citral hydrogenation once Co–Re interaction has formed.
Perceptions of male partner pressure to be thin and pornography use: Associations with eating disorder symptomatology in a community sample of adult women
Authors: Tylka Tracy L. , Calogero Rachel M. 
Published: January 2019

AbstractObjectivePartner‐specific factors have been neglected in eating disorder (ED) research. The present study examined two partner‐specific variables that were hypothesized to be linked to women's ED symptoms: perceived male partner thinness‐related pressures and pornography use.MethodCommunity women (N = 409) in relationships with men completed online anonymous measures of ED symptomatology, perceptions of male partner thinness‐related pressure and pornography use, and thin‐ideal internalization.ResultsPartner thinness‐related pressure was related to higher ED symptomatology, adjusting for age and thinness‐related pressures from media, friends, and family. Current and previous partner pornography use were related to higher ED symptomatology, adjusting for age and women's reports of being bothered by this use. Partner thinness‐related pressure and previous partner pornography use were associated with ED symptomatology both directly and through thin‐ideal internalization, whereas current partner pornography use was directly associated with ED symptomatology.DiscussionPerceptions of male partner thinness‐related pressure and pornography use constitute unique factors associated with women's ED symptomatology that may operate indirectly by positioning women to endorse thinness as a personal standard and directly (e.g., by trying to accommodate their partner's appearance preferences). This study's findings provide initial support for pursuing subsequent investigations to test these partner variables as ED risk factors.
A rangewide herbarium‐derived dataset indicates high levels of gene flow in black cherry (Prunus serotina)
Authors: Konrade Lauren , Shaw Joey , Beck James 
Published: January 2019

AbstractIsolation by Distance (IBD) is a genetic pattern in which populations geographically closer to one another are more genetically similar to each other than populations which are farther apart. Black cherry (Prunus serotina Ehrh.) (Rosaceae) is a forest tree species widespread in eastern North America, and found sporadically in the southwestern United States, Mexico, and Guatemala. IBD has been studied in relatively few North American plant taxa, and no study has rigorously sampled across the range of such a widespread species. In this study, IBD and overall genetic structure were assessed in eastern black cherry (P. serotina Ehrh. var. serotina), the widespread variety of eastern North America. Eastern North America. Prunus serotina Ehrh. var. serotina (Rosaceae). Dense sampling across the entire range of eastern black cherry was made possible by genotyping 15 microsatellite loci in 439 herbarium samples from all portions of the range. Mantel tests and STRUCTURE analyses were performed to evaluate the hypothesis of IBD and genetic structure. Mantel tests demonstrated significant but weak IBD, while STRUCTURE analyses revealed no clear geographic pattern of genetic groups. The modest geographic/genetic structure across the eastern black cherry range suggests widespread gene flow in this taxon. This is consistent with P. serotina's status as a disturbance‐associated species. Further studies should similarly evaluate IBD in species characteristic of low‐disturbance forests.
Plasma xanthine oxidoreductase activity in patients with decompensated acute heart failure requiring intensive care
Authors: Okazaki Hirotake , Shirakabe Akihiro , Matsushita Masato , Shibata Yusaku , Sawatani Tomofumi , Uchiyama Saori , Tani Kennichi , Murase Takayo , Nakamura Takashi , Takayasu Tsutomu , Asano Miwako , Kobayashi Nobuaki , Hata Noritake , Asai Kuniya , Shimizu Wataru 
Published: January 2019

AbstractAimsPlasma xanthine oxidoreductase (XOR) activity during the acute phase of acute heart failure (AHF) requires further elucidation.Methods and resultsOne hundred eighteen AHF patients and 231 control patients who attended a cardiovascular outpatient clinic were prospectively analysed. Blood samples were collected within 15 min of admission from AHF patients (AHF group) and control patients who visited a daily cardiovascular outpatient clinic (control group). Plasma XOR activity was compared between the two groups, and factors independently associated with extremely elevated XOR activity were identified using a multivariate logistic regression model. Plasma XOR activity in the AHF group (median, 104.0 pmol/h/mL; range, 25.9–423.5 pmol/h/mL) was significantly higher than that in the control group (median, 45.2 pmol/h/mL; range, 19.3–98.8 pmol/h/mL). The multivariate logistic regression model showed that serum uric acid (per 1.0 mg/dL increase, odds ratio: 1.280; 95% confidence interval: 1.066–1.536; P = 0.008) and lactate levels (per 1.0 mmol/L increase, odds ratio: 1.239; 95% confidence interval: 1.040–1.475; P = 0.016) were independently associated with high plasma XOR activity (>300 pg/h/mL) during the acute phase of AHF.ConclusionsPlasma XOR activity was extremely high in patients with severely decompensated AHF. This would be associated with a high lactate value and would eventually lead to hyperuricaemia in patients with AHF.