bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Commission européenne du Danube entre 1856 et 1914, ou l’histoire administrative de la première commission européenne
Authors: Pécaud Dominique , Pipaud Patrice 
Published: November 2024

Abstract
The European Danube Commission is distinguished by the presence of a substantial administrative body associated with a decision-making body made up of diplomats. Administrative action is one of the tasks assigned to it, such as the monitoring of regulations which requires the establishment of a transnational public administration. The originality of the administrative model of the European Danube Commission lies in the need to invent a bureaucratic functioning respecting the primacy of the diplomatic function. This article puts forward the idea that the solutions chosen by this commission contributed to the birth of an administrative practice of international organizations.
Factors that Influence Healthcare Professionals' Intentions towards Biosimilars
Authors: Alqahtani Mohammed , Al-Jedai Ahmed , Wertheimer Albert 
Published: November 2024

Background: Physicians often prescribe original biologic products to patients who have not used them before and are reluctant to switch to biosimilars. Biosimilars are highly similar versions of already-approved biologics, but healthcare professionals typically hesitate to transition patients from the original products to biosimilars. This study aims to investigate the factors that influence U.S. healthcare professionals' intentions to use biosimilars.
Methods: A cross-sectional study was conducted. 510 participants were eligible healthcare professionals (279 physicians and 231 pharmacists). The theory of planned behavior (TPB) is used to identify which factors affect healthcare professionals' intentions. Descriptive statistics, chi-square, and the logistic regression model tested the TPB constructs as predictors of intentions toward biosimilars.
Results: Among 279 physicians, most were aged 61 and above, with high (n = 142) and low (n = 137) intentions. Male physicians constituted 71% of the population. Attending physicians (66.3%) showed consistent perceptions towards biosimilars, primarily in the private sector (76.3%). Pharmacists (n = 231), a higher percentage of females demonstrated higher intentions compared to males (35.5% vs. 28.1%); the majority were community pharmacists. Associations between years of practice and intentions were significant. Positive correlations existed between beliefs and intentions, except for normative beliefs.
Conclusions: This study revealed diverse attitudes among healthcare professionals towards biosimilars in the USA. Pharmacists and physicians, especially those with limited experience, require ongoing education on biosimilar manufacturing pathways. This education supports the appropriate use of biosimilars and helps standardize federal and state legislation.
Bracketology in Pharmacy Education: The Impact of March Medication Madness on Student Engagement and Knowledge
Authors: Hursman Allison , Petry Natasha , Brynjulson Rebecca , Frenzel Jeanne , Miller Donald , Monson Elizabeth , Orr Megan , Richter Lisa , Viets Nice Joan 
Published: November 2024

Introduction. Gamification is being used in pharmacy education as a learning strategy to engage learners with educational content in innovative ways. Bracketology is one type of gamification that has not been described in pharmacy education literature. The goal of implementing a March Medication Madness activity was to increase student engagement and knowledge. The associated study aimed to assess activity goal achievement.
Innovation. The March Medication Madness project was developed for use in a capstone course offered in the final semester of the didactic pharmacy curriculum. Students created medication related pearls which were paired together in a 32-team tournament style bracket. Students then completed brackets to predict the winning pearls and voted biweekly to determine the most clinically significant pearl. Student knowledge was assessed pre- and post-activity along with a post-activity perception assessment.
Critical Analysis. Most students either agreed or strongly agreed that the activity increased understanding and stimulated interest in course material, while adding an element of fun to the course. There was a statistically significant increase (t51=3.34, p=0.002) in the average percentage of multiple-choice questions students answered correctly from the pre-test (57.7%±1.5%) to the post-test (63.1%±1.9%). Pearls that progressed the farthest within the voting were no more likely to be associated with an increase in knowledge than pearls that were eliminated in the first two rounds.
Next Steps. Implementation of a bracketology activity was perceived as fun and engaging for students, and they felt that it aided in their understanding of course material. However, the actual increase in knowledge was limited. This shows the importance of structuring gamification in a way that truly provides educational value and enforces the need to make modifications to the activity for future iterations to promote student learning.
Community-Based Pharmacists’ Perspectives on Prescribing Authority for the Minor Ailments and Contraceptive Service in British Columbia
Authors: Dahri Karen , Wong Yiu-Ching Jennifer , Loewen Peter , Basi Jiven , Sidhu Sohail , Ragsdale Parkash , Barry Arden , Pammett Rob 
Published: November 2024

Background
Recent changes to legislation in British Columbia (BC) have expanded the scope of pharmacist-provided services to include pharmacist prescribing for minor ailments and contraception (PPMAC). The purpose of this study was to gather community-based pharmacists’ perspectives on these changes to practice.
Methods
This was a cross-sectional online survey study. The study population was pharmacists practicing in community settings in BC. A 28-question survey was developed to capture the uptake of prescribing in the pharmacists’ practices, their views on PPMAC, educational supports, and workplace-specific questions. Invitations to participate were disseminated by using fax, social media platform posts, and email.
Results
A total of 246 participants completed all or part of the survey. A majority felt they should be able to assess and prescribe for minor ailments and contraception, and were satisfied with the regulatory changes. Pharmacists had varying degrees of comfort with prescribing for specific patient populations, with the highest for patients >75 years of age and lowest for patients with renal disease. Respondents felt that patients who were without a primary care provider or did not have easy access to walk-in clinics would benefit the most from PPMAC. Pharmacists expressed concerns about their workplace’s level of support for their providing these new services to patients.
Discussion
Most pharmacist respondents were supportive of and have begun prescribing for minor ailments and contraception in their practices. While they identified many perceived benefits to patient care, workplace barriers may hinder full provision of pharmacist prescribing in their practice.
Mechanistic Characteristics of HRS-WC Mixture Using Tabas Stone Waste Coated With Plastic Waste As Aggregate
Authors: Ariawan I Made Agus , Wedagama Dewa Made Priyantha , Elizar  , Genta Putra Komang Alit , I Putu Chandra Wibawa  
Published: November 2024

Utilization of tabas stone waste and polypropylene (PP) plastic waste has not been carried out massively and optimally because it lacks economic value. The Tabas stone waste can be used as an aggregate for pavement. The porous characteristic of tabas stone results in a high rate of absorption and abrasion, so modifications are made by coating the aggregate with an PP plastic. The aim of this experiment was to determine the characteristics of the HRS-WC mixture with the aggregate of tabas stone coated with plastic. The initial step of this research was testing the tabas stone aggregates, bitumen material, and PP plastic according to the SNI procedure, the next step was Marshall test to find the Optimum Bitumen Content (OBC), the OBC value was obtained by 10%. Coating the aggregate with shredded plastic measuring ± 1 cm2 was done on coarse aggregate only using the dry method with the proportions of plastic are 5% and 10% of the total weight of coarse aggregate. The characteristics of the aggregate coated with plastic decrease in the value of absorption and abrasion, but only 10% of the plastic content met the specifications with a value of 2.5% and 19.63%. The Marshall testing on the HRS-WC mixture with plastic-coated aggregates was done at variations in bitumen content of 8.5%; 9%; 9.5%. The mixture at 5% plastic content only 9.5% bitumen content met the specifications, namely: stability 1352.72 kg, flow 3.39 mm, MQ 402.23 kg/mm, VIM 5.75%, VMA 18.62% , and VFB 69.16%. When at 10% plastic content, only 9% and 9.5% bitumen content met the specifications, namely the stability of 1370.06 kg; 1456.21 kg, flow 3.81 mm; 3.98 mm, MQ 365.31 kg/mm; 370.06 kg/mm, VIM 5.77%; 4.89%, VMA 18.07%; 18; 15%, and VFB 68.05%; 73.04%. Asphalt mixture of 9% bitumen content, 10% plastic content has more ITSM value compared to 5% plastic content. This is due to the plastic content in the mixture of 10% plastic content which causes the mixture to be stiffness. Asphalt mixture with a plastic content of 5%, with an bitumen content of 9.5% faster than the mixture with an bitumen content of 8.5% and 9% in the ITFT test. Asphalt mixture with a plastic content of 5%, with a variation of bitumen of 8.5% experienced a decrease in the dynamic creep strain value until the bitumen content was 9.5%. A mixture with a plastic content of 5% aggregate coating is recommended for HRS WC that uses tabas stone.
Las criadas españolas como pasajeras en los viajes transatlánticos a Nueva España, 1580-1699
Authors: Orta Gómez Diana Patricia 
Published: November 2024

La historiografía de la migración femenina española en América tiene una deuda pendiente respecto al estudio de las criadas como pasajeras dentro de las grandes embarcaciones que cruzaron el Atlántico. Estas mujeres constituyeron un grupo heterogéneo en orígenes y especialidades domésticas. En este ensayo, a través de una nueva relectura de las licencias de pasajeros se caracterizarán a las criadas españolas y se analizarán sus condiciones sociales en los viajes transatlánticos.
स्नातक तहको अनिवार्य नेपालीमा नाटक शिक्षण
Authors: ढुङगाना Dhungana शोभाकुमारी Shovakumari 
Published: November 2024

प्रस्तुत अध्ययन त्रिभुवन विश्वविद्यालयअन्र्तगत अनिवार्य नेपाली विषयको स्नातक तह (कोड नं ४०२) को निर्धारित पाठ्यक्रमअनुसार ‘स्नातक तहको अनिवार्य नेपालीमा नाटक शिक्षण’ शीर्षकमा केन्द्रित छ । त्रिभुवन विश्वविद्यालयअन्र्तगत चार वर्षे स्नातक तह अनिवार्य नेपालीको दोस्रो वर्षको निर्धारित पाठ्यक्रममा विजय मल्लको ‘सत्ताको खोजमा’ र कृष्ण शाह यात्रीको ‘पीडा आरोहण’ गरी दुई एकाङ्की नाटक समावेश गरिएको छ । नाटक शिक्षणको प्रभावकारिता र औचित्यको जिज्ञासामा केन्द्रित प्रस्तुत अध्ययनमा वर्णनात्मक र विश्लेषणात्मक विधि अपनाइएको छ । स्नातक तहको अनिवार्य नेपाली विषय ऐच्छिक विषय नभएर विभिन्न विषय लिएर पढ्ने सबै विद्यार्थीहरूका लागि राखिएको विषय भएको हुनाले उनीहरूलाई नेपाली व्याकरण, बोध पठन तथा भाषा साहित्यको गहन र विस्तृत रूपमा विश्लेषण, मूल्याङ्कन गर्ने पाठ्यक्रमको उद्देश्य होइन । नाट्यकृतिको भाव तथा विचारको आस्वादन गरी सामान्य समीक्षा तथा पाठक प्रतिक्रिया लेख्ने क्षमतासमेत बढाउन सकून् भन्ने उद्देश्य अनुरूप नाट्य विधा पाठ्यक्रममा समावेश गरिएको हो । पाठ्यांशमा निर्धारित दुई नाटकको अध्ययनबाट नाट्यकृतिको अध्ययनसँग सम्बन्धित भई पाठक प्रतिक्रिया तथा समालोचना गर्न सक्ने, विचार तथा भावको समीक्षा गर्न सक्र्ने गरी तयार गरिएको चार वर्षे अनिवार्य नेपाली दोस्रो वर्षको पाठ्यक्रमअनुसार नाटक शिक्षण निकै औचित्यपूर्ण र उपयोगी भएको निष्कर्ष रहेको छ ।
STUDI TIPE AGROFORESTRI DI KAMPUNG LONG PAKAQ BARU KECAMATAN LONG PAHANGAI KABUPATEN MAHAKAM ULU PROVINSI KALIMANTAN TIMUR
Authors: Pantau Syprianus , Tirkaamiana Muhammad Taufan , Bakrie Ismail , Jumani Jumani , Emawati Heni 
Published: November 2024

Agroforestri merupakan suatu tipe yang mengkombinasikan antara komponen hutan dengan komponen pertanian yang dapat memperbaiki lingkungan dan dapat meningkatkan ekonomi masyarakat. Penelitian ini bertujuan untuk mengatahui tipe Agroforestri yang diterapkan masyarakat Kampung Long Paakaq Baru. Manfaat penelitian diharapkan dapat menambah pengetahuan dan wawasan menyangkut tipe Agroforestri yang diterapkan masyarakat Kampung Long Pakaq Baru. Metode penelitian menggunakan metode deskriptif kualitatif dengan teknik pengumpulan data didapatkan melalui wawancara, kuesioner dan observasi langsung di lapangan. Penelitian ini dilaksanakan di Kampung Long Pakaq Baru Kecamatan Long Pahangai Kabupaten Mahakam Ulu pada lahan masyarakat yang dikelola dengan sistem Agroforestri. Penelitian ini dilakukan selama dua bulan. Hasil dari penelitian ini terdapat 1 tipe Agroforestri yaitu tipe Agrosilvikultur yang merupakan campuran tanaman kehutanan, tanaman pangan dan tanaman hortikultura.
ШЛЯХИ ПІДВИЩЕННЯ ХАРЧОВОЇ ТА БІОЛОГІЧНОЇ ЦІННОСТІ ХЛІБОБУЛОЧНИХ ВИРОБІВ
Authors: Горач О. О. 
Published: November 2024

Анотація. В статті проведено аналіз шляхів підвищення харчової та біологічної цінності хлібобулочних виробів та розглянуто основні способи їх реалізації. Відомо, що на сьогоднішній день розроблено технології виробництва хлібобулочних виробів для здорового харчування, профілактики та зниження ризику найпоширеніших видів захворювань: гіпертонії, атеросклерозу, ожиріння, а також для підвищення імунітету та захисту від негативного впливу навколишнього середовища. Дослідження показує, що використання функціональних інгредієнтів під час приготування хлібобулочних виробів дозволяє збагатити продукт незамінними амінокислотами, ненасиченими жирними кислотами, мінеральними речовинами, харчовими волокнами та вітамінами, що дозволяє значно підвищити харчову та біологічну цінність. Результати експериментальних досліджень та економічні розрахунки свідчать про доцільність впровадження таких рецептур та технологій у виробництво. Показано, що на сьогодні головним завданням вітчизняної харчової промисловості є розробка нових технологій для переробки сільськогосподарської сировини в високоякісні продукти, які сприяють профілактиці захворювань та компенсують дефіцит вітамінів, мікро- та макроелементів й інших корисних речовин. Основними чинниками, які впливають на виробництво хлібобулочних виробів, є наявність сировини, енергозабезпечення, логістика, трудові ресурси. Однак, основною причиною падіння виробництва є втрата залишків виробничих потужностей та втрата врожаїв зернових, способів зберігання та переробки ускладняються проблемами. Зміни логістичних шляхів та зниження доходності агропідприємств через блокування експорту зернових та падіння цін на внутрішньому ринку призвели до нестачі ринку добрив та засобів захисту рослин, що відобразилося на якості зернових поточного сезону. Використання насіння льону та конопель у хлібобулочних виробах викликає особливий інтерес як цінний харчовий інгредієнт. Насіння конопель містить жирні кислоти омега-6 і омега-3, високоякісний білок, харчові волокна і мінерали, а також є важливим функціональним інгредієнтом з точки зору хімічного складу. Лляне насіння багате на вітаміни, мінерали, містить жирні кислоти омега-6 і омега-3. Основними речовинами лляного насіння є одні з найважливіших ферментів вуглеводного та енергетичного обміну, які забезпечують організм енергією і пластичними речовинами, а також метаболізм амінокислот з розгалуженим ланцюгом. Дефіцит вітаміну В1 призводить до серйозних розладів нервової, травної та серцево-судинної систем. Результати проведених експериментальних досліджень з розробки технологій та рецептур безглютенових хлібобулочних виробів показали доцільність заміни традиційного глютенового борошна на безглютенове. Застосування технології та рецептур, спрямоване на поліпшення якості, підвищення біологічної та поживної цінності хлібобулочних виробів спеціального призначення.
Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China
Authors: Ji Hongxiang , Sun Hualin , Zhang Yinghui , Zhao Ziyi , Gao Xin , Wang Chunhe , Yang Yang , Zhang Xiaodong , Gao Jianyong , Man Dequan , Yang Qian , Yang Ying , Yue Chengbin , Chen Changjiang , Ding Xiaoheng , Ni Tongshang 
Published: November 2024

AimTo evaluate the real-life effectiveness and safety of hydrogen inhalation (HI) therapy as an additional treatment in Chinese adults with hypertension.MethodsThis observational, retrospective clinical study included hypertensive patients receiving routine antihypertensives with or without HI initiation from 2018 to 2023. Participants were assigned to the HI group or non-HI group (control group) after propensity score matching. The changes in mean systolic blood pressure (SBP) level during the 24-week follow-up period in different groups were examined primarily. The secondary outcome was the changes in diastolic blood pressure (DBP) and blood pressure (BP) control rate during the study. Several subgroup and sensitivity analyses were performed to confirm the robustness of our main findings. Adverse event (AE) was also assessed in patients of both groups.ResultsIn total, we selected 2,364 patients into the analysis. Both mean SBP and DBP levels significantly decreased in the HI group compared to control group at each follow-up visit with the between group difference of −4.63 mm Hg (95% CI, −6.51 to −2.74) at week 8, −6.69 mm Hg (95% CI, −8.54 to −4.85) at week 16, −7.81 mm Hg (95% CI, −9.57 to −6.04) at week 24 for SBP, and −1.83 mm Hg (95% CI, −3.21 to −0.45) at week 8, −2.57 mm Hg (95% CI, −3.97 to −1.17) at week 16, −2.89 mm Hg (95% CI, −4.24 to −1.54) at week 24 for DBP. Patients in the HI group were more likely to attain controlled BP at the follow-up period with odds ratio of 1.44 (95% CI, 1.21–1.72) at week 8, 1.90 (95% CI, 1.59–2.27) at week 16, and 2.24 (95% CI, 1.87–2.68) at the end. The trends of subgroup and sensitivity analyses were mostly consistent with the main analysis. The incidences of AEs were similar between the HI group and control group with all p-value &gt;0.05.ConclusionThe HI therapy is related to significant amelioration in BP levels with acceptable safety profile in Chinese hypertensive adults after 24 weeks of treatment, building a clinical ground for further research to evaluate the antihypertensive effect of HI therapy.
Fitness and psychological effects of tele-exercise in healthy populations. Preliminary study
Authors: Fucarino Alberto , Zimatore Giovanna , Fabbrizio Antonio , Garrido Nuno D. , Reis Victor Machado , Vilaça-Alves José , Sausa Martina , Matteo Barbara , Peixoto Rafael , Perušina Paulina , Aristova Aleksandra , De Giorgio Andrea , Baldari Carlo , Macaluso Filippo , Iuliano Enzo , Cantoia Manuela 
Published: November 2024

BackgroundThe study investigates the impact of tele-exercise on physical fitness and psychological well-being in healthy individuals. Tele-exercise, facilitated by technology, offers a flexible and accessible alternative to traditional exercise, particularly beneficial during restricted in-person interactions.MethodsIn this study, 52 participants were divided into three groups: athletes, women, and young adults. They took part in an eight-week tele-exercise program, either synchronously or asynchronously. Physical fitness was evaluated using tests such as the 2-Minute Step and Curl Up Test, while psychological well-being was assessed using the Psychological General Well-Being Index (PGWBI) and Perceived Stress Scale (PSS-10).ResultsSignificant improvements in physical fitness and psychological well-being were observed in post-intervention across all groups, regardless of training mode. In the fitness tests, a significant improvement was obtained in the 2-Minute-Step (p = 0.004), in the curls up (p = 0.017), and in squats test (p = 0.004). In the forward bending test, the increment was very close to the significance (p = 0.051). In the psychological well-being tests, both PGWBI and WHO-5 scores increased after the training (p = 0.024 and p = 0.001 respectively) with no significant change in the PSS-10 score. The study found that tele-exercise can effectively introduce physical activity to previously inactive individuals and motivate them to adopt healthier lifestyle behaviors.ConclusionsThe TELEexe4ALL project demonstrates the potential of tele-exercise to improve physical fitness and psychological well-being. The study suggests that tele-exercise is a feasible and well-accepted approach for enhancing overall wellness in healthy populations.
Introducing dental practice management in the undergraduate curriculum through an interprofessional module: experience from an Indian dental school
Authors: Sujir Nanditha , Naik Dilip G. , Mohammed Ciraj Ali , Jain Animesh , Uppoor Ashita 
Published: November 2024

IntroductionThis study aimed to evaluate the effectiveness of a dental practice management education module developed through interprofessional collaboration.Materials and methodsA dental practice management module was developed through need assessment, literature review, and interprofessional collaboration. The IP team included dental practitioners, dental educators, business expert, lawyer, bioethicist, engineer, and architects. Thirty interns were included in the study. Participants were assessed through pre-and post-test. Evaluation of the program was carried out by obtaining feedback from the students and dental practitioners who were invited to attend the program. The pre-and post-test results were compared by paired student t-test. p-value of &lt;0.01 was considered significant. The content of the feedback forms was subjected to qualitative and descriptive analysis.ResultsThrough the process of module preparation, pertinent competencies were identified and included in the program. There was a statistically significant increase in knowledge among students with respect to the domains included, as shown in the pre-post-test comparisons. The feedback obtained was positive. IP collaboration in module design and implementation was considered an important factor for dental practice management.ConclusionPractice management education can be made effective through IP collaborations.
Radiation therapy in functioning and no functioning pituitary neuroendocrine tumor: systematic review of the recent literature after 2011
Authors: Hemaidia Racha-Miloda , Cebula Hélène , Goichot Bernard , Noel Georges 
Published: November 2024

SummaryNeuroendocrine pituitary tumor, a benign cells proliferation, can cause significant morbidity due to its local invasiveness and secretory properties. Historically, radiotherapy has been employed as a second or third-line treatment option, with studies dating back to the mid-20th century. However, advancements in radiotherapy techniques, such as intensity-modulated radiation therapy (IMRT), stereotactic radiosurgery, and proton therapy, have revolutionized treatment approaches. This review aims to critically evaluate the recent literature (2011–2022) on the use of radiotherapy in both functioning and nonfunctioning neuroendocrine pituitary tumor. We employed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology to systematically analyze 52 articles, focusing on local and hormonal control, radiotherapy protocols, and treatment-related side effects.