bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative assessment of urban wetland dynamics using high spatial resolution satellite imagery between 2000 and 2013
Authors: Hu Tangao , Liu Jiahong , Zheng Gang , Li Yao , Xie Bin 
Published: May 2018

AbstractAccurate and timely information describing urban wetland resources and their changes over time, especially in rapidly urbanizing areas, is becoming more important. We applied an object-based image analysis and nearest neighbour classifier to map and monitor changes in land use/cover using multi-temporal high spatial resolution satellite imagery in an urban wetland area (Hangzhou Xixi Wetland) from 2000, 2005, 2007, 2009 and 2013. The overall eight-class classification accuracies averaged 84.47% for the five years. The maps showed that between 2000 and 2013 the amount of non-wetland (urban) area increased by approximately 100%. Herbaceous (32.22%), forest (29.57%) and pond (23.85%) are the main land-cover types that changed to non-wetland, followed by cropland (6.97%), marsh (4.04%) and river (3.35%). In addition, the maps of change patterns showed that urban wetland loss is mainly distributed west and southeast of the study area due to real estate development, and the greatest loss of urban wetlands occurred from 2007 to 2013. The results demonstrate the advantages of using multi-temporal high spatial resolution satellite imagery to provide an accurate, economical means to map and analyse changes in land use/cover over time and the ability to use the results as inputs to urban wetland management and policy decisions.
Resolved millimeter-dust continuum cavity around the very low mass young star CIDA 1
Authors: Pinilla Paola , Natta Antonella , Manara Carlo F. , Ricci Luca , Scholz Aleks , Testi Leonardo 
Published: May 2018

Context. Transition disks (TDs) are circumstellar disks with inner regions highly depleted in dust. TDs are observed in a small fraction of disk-bearing objects at ages of 1–10 Myr. They are important laboratories to study evolutionary effects in disks, from photoevaporation to planet–disk interactions.
Aim. We report the discovery of a large inner dust-empty region in the disk around the very low mass star CIDA 1 (M⋆ ~ 0.1−0.2 M⊙). Methods. We used ALMA continuum observations at 887 µm, which provide a spatial resolution of 0″.21 × 0″.12 (~15 × 8 au in radius at 140 pc).
Results. The data show a dusty ring with a clear cavity of radius ~20 au, the typical characteristic of a TD. The emission in the ring is well described by a narrow Gaussian profile. The dust mass in the disk is ~17 M⊕. CIDA 1 is one of the lowest mass stars with a clearly detected millimeter cavity. When compared to objects of similar stellar mass, it has a relatively massive dusty disk (less than ~5% of Taurus Class II disks in Taurus have a ratio of Mdisk/M⋆ larger than CIDA 1) and a very high mass accretion rate (CIDA 1 is a disk with one of the lowest values of Mdisk/Ṁ ever observed). In light of these unusual parameters, we discuss a number of possible mechanisms that can be responsible for the formation of the dust cavity (e.g. photoevaporation, dead zones, embedded planets, close binary). We find that an embedded planet of a Saturn mass or a close binary are the most likely possibilities.
Medical and Semi-surgical Treatments for Fuchs Endothelial Corneal Dystrophy
Authors: Wacker Katrin , Baratz Keith , Fautsch Michael , Patel Sanjay 
Published: May 2018

AbstractUnraveling the genetic mechanisms of Fuchs endothelial corneal dystrophy has opened new possibilities for future targeted medical therapy of the disease. Until these possibilities mature, regenerative semi-surgical approaches by cell injection or cell sheet transfer could help expand the donor pool, and possibly enable autologous transplantation. Descemet membrane stripping alone and acellular Descemet membrane transfer are more immediate surgical approaches that could be temporary treatments in some patients, though there is a lack of understanding of the factors that predict success for these procedures. Regardless of approach, clinical trials will be necessary, and clinicians should therefore try to standardize their methods of assessing disease severity and the outcomes of intervention.
Straight-Leg-Raise-Test
Authors: Binder Raymond 
Published: May 2018

ZusammenfassungAssessments sind objektive standardisierte Testverfahren, mit denen sich in der
Physiotherapie die Situation des Patienten beurteilen lässt. Sie liefern
Hinweise für die Optimierung und weitere Therapieplanung. Die AG Akademisierung
stellt im VPTMAGAZIN valide Tests steckbriefartig vor.
Radial Arterial Access for Hepatobiliary and Gastrointestinal Arterial Interventions: Initial Experience
Authors: Rachapalli Vamsidhar , Jaganathan Sriram , Palaniswamy Mohnish , Tiruchunapalli Deepashree , Chappidi Sridhar , Inuganti Srikar , Uthappa Mangerira 
Published: May 2018

Abstract
Introduction Radial artery access is being more commonly used for visceral and peripheral arterial interventions. Its use in the Indian subcontinent is not well reported. The aim of this study was to report outcomes of radial arterial access during arterial interventions of the hepatobiliary and gastrointestinal system.
Methods In this retrospective study, patients who underwent radial artery access for hepatobiliary and gastrointestinal interventions from January 2015 to June 2017 were identified from the interventional database. Complications related to radial artery access and catheter placement in the visceral arteries, procedural modifications, and conversion to the standard femoral arterial access were analyzed.
Results Total 32 patients were included in this study. Total 46 procedures (radial artery access) were performed. Nine patients had radial artery access on more than two occasions; 95% of the procedures involved interventional oncologic treatments. Patients were followed up for an average of 4 months following radial arterial access. Technical success was 98.7%. One patient developed radial artery spasm, and the access was abandoned. This patient subsequently underwent brachial arterial access. No patient required conversion to a femoral arterial access. No other complications were encountered during the follow-up. Compared with femoral arterial access, radial arterial access required longer catheters were needed for super selective catheterization of the visceral arteries.
Conclusion Radial arterial access for arterial interventions in the hepatobiliary and gastrointestinal systems was technically feasible with no significant complications. Long catheters are required for selective catheterization of the visceral arteries with this approach.
Massive Pulmonary Embolism Thrombolysis: Early Clinical Markers of Treatment Efficacy
Authors: Portnoy Elie , Wadhwa Vibhor , Barbosa Mariana , Weiss Clifford , Holly Brian , Lessne Mark , Hong Kelvin , Tamrazi Anobel 
Published: May 2018

AbstractThe authors seek to evaluate hemodynamic parameters as potential clinical markers of real-time clinical improvement among patients with massive pulmonary embolism (PE) in correlation with post-thrombolytic pulmonary arterial pressure improvement and overall clinical outcome. Thirteen patients with submassive or massive PE were admitted to the interventional radiology service and treated with catheter-directed thrombolysis. Among the four patients who qualified as massive PE, systolic blood pressure (BP) and vasopressor dependence suggested meaningful trends toward clinical improvement, after only 26.4% of treatment course/dose. Hemodynamic parameters such as systolic BP and inotropic vasopressor dependence may be considered in future treatment protocols as early indicators of treatment response.
Middle Ear Actinomycosis
Authors: Coutinho Gil , Spratley Jorge , Saldanha Inês , Castro Cristina , Pinheiro Jorge , Santos Margarida 
Published: May 2018

AbstractMiddle ear actinomycosis is an atypical and exceedingly rare anaerobic infection. The authors report a case of a 7-year-old girl with persistent right side otalgia, conductive hearing loss, and headache. Otoscopic findings included a thickened, intact, and bulging tympanic membrane. Computed tomography imaging revealed soft tissue density filling the middle ear with areas of bone erosion. Typical sulfur granules were found on surgical exploration. Actinomycosis was diagnosed by histopathological examination. Penicillin was prescribed for 5 weeks followed by oral amoxicillin for 6 months. Recovery was uneventful and with a 2-year follow-up, no recurrence or complications were observed.
Myasthenie – Exazerbation und Krise
Authors: Schroeter Michael , Thayssen Günther , Kaiser Julia 
Published: May 2018

ZusammenfassungExazerbation und Krise stellen die schwersten Verlaufsformen einer Myasthenia gravis dar. Die myasthene Krise ist auch heutzutage immer noch mit einer Letalität von mindestens 2 – 3% verbunden. In dieser Übersicht stellen wir dar, wie Exazerbation oder drohende Krise vermieden, erste Anzeichen erkannt und eine konsequente Therapie eingeleitet werden kann. Dazu können neben einer sinnvollen symptomatischen Therapie mit Cholinesterasehemmer, die Therapie mit Immunadsorption oder Plasmaseparation, Immunglobulinen und Kortisongaben, die immunsuppressive Therapie und die Gabe von monoklonalen Antikörpern gehören. Die neurointensivmedizinischen Maßnahmen schließen ein strukturelles Dysphagie-Assessment und die Behandlung eines Delirs mit ein. Besonderer Aufmerksamkeit bedürfen das perioperative Management bei der Thymektomie, die Beatmung und die Entwöhnung vom Respirator.Die Einleitung einer konsequenten immunsuppressiven Therapie und die Anbindung an eine spezialisierte Behandlungseinheit helfen erneute Exazerbationen und Krisen zu verhindern.
Die okuläre Myasthenia gravis
Authors: Kirzinger Lukas , Schötz Sophie , Schalke Berthold 
Published: May 2018

ZusammenfassungIn historischen Publikationen wurde die okuläre Myasthenie (MG) stets als eigenständige Entität beschrieben. Allerdings entwickeln weit über 50 % der Patienten im Verlauf eine generalisierte Myasthenie. Ausschließlich okuläre Symptome können bei allen erworbenen Myasthenien die Initialsymptomatik darstellen, trotzdem scheint es eine kleine Gruppe von Patienten zu geben, bei denen lebenslang nur eine rein okuläre Symptomatik auftritt. Spezielle Mechanismen der Immunologie, Biochemie und Pathophysiologie führen lokal zu sehr spezifischen Veränderungen an der neuromuskulären Synapse, die in einer rein okulären Myasthenie resultieren. Die Diagnostik ist dabei erschwert, da nur bei weniger als 50 % der Patienten Antikörper gegen den Acetylcholin Rezeptor oder MuSK nachweisbar sind. Dies erfordert stets eine sorgfältige Differenzialdiagnostik, um andere, isoliert okuläre Symptome verursachende Krankheitsentitäten nachzuweisen bzw. auszuschließen. Die Therapie der okulären Myasthenie unterscheidet sich nicht grundlegend von den anderen Subgruppen der Myasthenie. In der symptomatischen Behandlung wird sie mit Cholinesterasehemmern durchgeführt, die kausale Behandlung erfolgt immunsuppressiv mit Corticosteroiden und anderen üblicherweise eingesetzten Immunsuppressiva (Azathioprin, MMF etc.). Die Thymektomie wird im Allgemeinen bei der primär rein okulären Myasthenie nicht empfohlen. Kontrollierte, randomisierte Studien hierzu gibt es bisher jedoch nicht.
Myasthenie und Familienplanung, Schwangerschaft und Geburt
Authors: Thieme Andrea , Kalischewski Petra 
Published: May 2018

ZusammenfassungMyasthenia gravis pseudoparalytica betrifft Frauen im Alter unter 40 Jahren etwa 3-mal häufiger als Männer. Daraus resultieren für die Frauen und ihre behandelnden Ärzte zahlreiche Fragen zu Familienplanung, Schwangerschaft und Geburt bei Myasthenie. Das Outcome für Mutter und Kind hängt stark von dem Wissen über den Einfluss der Schwangerschaft auf die Myasthenie, über therapeutische Besonderheiten, über ihre Bedeutung für Entbindung und das Neugeborene ab. Die vorliegende Arbeit gibt einen Überblick über die klinischen Besonderheiten und will Patientinnen und ihre Ärzte bei Kinderwunsch, im Verlauf von Schwangerschaft, Geburt sowie Neonatalperiode unterstützen.Durch ausführliche Beratung, gute Vorbereitung, und Unterstützung durch Partner und Familie ist die Erfüllung des Kinderwunsches für Myasthenie-Patientinnen möglich. Die Risiken für Mutter und Kind lassen sich durch entsprechende Vorsichtsmaßnahmen und interdisziplinäre Behandlung sehr gering halten.
Therapiestandards und individualisierte Therapie bei der Myasthenia gravis
Authors: Urban Peter , Jacobi Christian , Jander Sebastian 
Published: May 2018

ZusammenfassungFür die Myasthenia gravis stehen eine Reihe gut etablierter Therapiestandards zur Verfügung, die sowohl die symptomatische Therapie mit Acetylcholinesterasehemmern als auch eine breite Palette immunologisch-basierter Therapien umfassen. Hiermit lässt sich bei der Mehrzahl der Patienten ein gutes Therapieergebnis mit weitgehender Beschwerderemission erzielen. Für die optimale individualisierte Therapie bietet die Behandlung in spezialisierten Myastheniezentren mit der Integration ambulanter und stationärer Infrastruktur und breiter interdisziplinärer Kompetenz entscheidende Vorteile.
Der Arzt im Wirtschaftsstrafrecht: Welche Risiken bestehen, welche Präventionsinstrumente versprechen Erfolg?
Authors: Ebermann Thorsten , Schneider Hendrik 
Published: May 2018

ZusammenfassungDie Einführung der Straftatbestände zur Bekämpfung von Korruption im Gesundheitswesen (§§ 299a, 299b StGB) haben bei den Normadressaten auf allen Ebenen Verunsicherung herbeigeführt. Diese wird durch unsubstantiierte Anzeigen seitens der Kostenträger und/oder den Kassenärztlichen Vereinigungen sowie durch kontextlose und vorschnelle Auslegung der Rechtsmaterie (zuletzt seitens der Generalstaatsanwaltschaft Thüringen) teilweise künstlich aufrechterhalten. Dieser Beitrag macht nicht nur deutlich, welche (politische) Interessenslage bei den Kostenträgern und sonstigen Benefiziaren dieser unklaren Rechtlage besteht. Er zeigt darüber hinaus – unter Beachtung der eigentlich und ursprünglich gesetzgeberischen Motivationslage nebst Analyse der Tatbestandsmerkmale – anhand relevanter Fallgestaltungen auf, dass weiterhin eine Vielzahl an kooperativen Möglichkeiten zwischen Ärzten untereinander, Ärzten und Industrie sowie Ärzten und Krankenhäusern bestehen und unter welchen Voraussetzungen diese rechtlich möglich sind.
Higher-Order Parabolic Equations with VMO Assumptions and General Boundary Conditions with Variable Leading Coefficients
Authors: Dong Hongjie , Gallarati Chiara 
Published: May 2018

AbstractWe prove weighted mixed $L_{p}(L_{q})$-estimates, with $p,q\in (1,\infty )$, and the corresponding solvability results for higher-order elliptic and parabolic equations on the half space ${\mathbb{R}}^{d+1}_{+}$ and on general $C^{2m-1,1}$ domains with general boundary conditions, which satisfy the Lopatinskii–Shapiro condition. We assume that the elliptic operators A have leading coefficients that are in the class of vanishing mean oscillations both in the time and the space variables and that the boundary operators have variable leading coefficients. The proofs are based on and generalize the estimates recently obtained by the authors in [6].
A Qualitative Study of the Real-world Experiences of Infectious Diseases Fellows Regarding Antibiotic Stewardship
Authors: Morgan Jake R , Barlam Tamar F , Drainoni Mari-Lynn 
Published: May 2018

Abstract

Background
Antibiotic-resistant bacterial infections are a major threat to public health, yet improper use of antibiotics remains high. Infectious Diseases (ID) fellows play a major role in antibiotic stewardship efforts, but there is little research on how they view stewardship activities. We performed a qualitative study to explore ID fellows’ experiences and perspectives regarding their antibiotic stewardship training and their role as future antibiotic stewards.

Methods
We conducted 17 in-depth interviews with ID fellows across the country. The interviews were transcribed verbatim by the study team, and we used grounded theory to generate themes from these interviews

Results
Fellows focused on concrete tasks of stewardship such as performing antibiotic approvals, didactic and case-based education, and interactions with other physicians and pharmacists. There was little focus on the broader public health relevance of antibiotic stewardship. Pharmacists, not ID physician leaders, were identified as fellows’ primary resource for antibiotic teaching. Several fellows suggested that stewardship programs should be led by pharmacists.

Conclusions
ID fellowship training is not successfully conveying the public health importance of antibiotic stewardship or the role of ID physicians as leaders of antibiotic stewardship programs. Fellows are more focused on concrete tasks related to stewardship. ID training programs and societies should consider developing robust curricula involving fellows in the operation of the stewardship program itself, not solely in antibiotic approvals, emphasizing aspects of the program such as complex problem solving that fellows find most compelling, and emphasizing the important role these programs serve in improving public health.
Validation of Noninvasive Absolute Intracranial Pressure Measurements in Traumatic Brain Injury and Intracranial Hemorrhage
Authors: Kienzler Jenny C , Zakelis Rolandas , Bäbler Sabrina , Remonda Elke , Ragauskas Arminas , Fandino Javier 
Published: May 2018

Abstract

BACKGROUND
Increased intracranial pressure (ICP) causes secondary damage in traumatic brain injury (TBI), and intracranial hemorrhage (ICH). Current methods of ICP monitoring require surgery and carry risks of complications.

OBJECTIVE
To validate a new instrument for noninvasive ICP measurement by comparing values obtained from noninvasive measurements to those from commercial implantable devices through this pilot study.

METHODS
The ophthalmic artery (OA) served as a natural ICP sensor. ICP measurements obtained using noninvasive, self-calibrating device utilizing Doppler ultrasound to evaluate OA flow were compared to standard implantable ICP measurement probes.

RESULTS
A total of 78 simultaneous, paired, invasive, and noninvasive ICP measurements were obtained in 11 ICU patients over a 17-mo period with the diagnosis of TBI, SAH, or ICH. A total of 24 paired data points were initially excluded because of questions about data independence. Analysis of variance was performed first on the 54 remaining data points and then on the entire set of 78 data points. There was no difference between the 2 groups nor was there any correlation between type of sensor and the patient (F[10, 43] = 1.516, P = .167), or the accuracy and precision of noninvasive ICP measurements (F[1, 43] = 0.511, P = .479). Accuracy was [−1.130; 0.539] mm Hg (CL = 95%). Patient-specific calibration was not needed. Standard deviation (precision) was [1.632; 2.396] mm Hg (CL = 95%). No adverse events were encountered.

CONCLUSION
This pilot study revealed no significant differences between invasive and noninvasive ICP measurements (P < .05), suggesting that noninvasive ICP measurements obtained by this method are comparable and reliable.
Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
Authors: Alzahofi Noura , Robinson Christopher L. , Welz Tobias , Page Emma L. , Briggs Deborah A. , Stainthorp Amy K. , Reekes James , Elbe David A. , Straub Felix , Tate Edward W. , Goff Philip S. , Sviderskaya Elena V. , Cantero Marta , Montoliu Lluis , Bailly Maryse , Kerkhoff Eugen , Hume Alistair N. 
Published: May 2018

AbstractCell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that motor myosin-Va, works with dynamic actin tracks, to drive long-range organelle dispersion in microtubule depleted cells. This suggests that in animals, as in yeast and plants, myosin/actin can drive long-range transport. Here we show that SPIRE1/2 and formin-1 (FMN1) proteins generate actin tracks required for myosin-Va-dependent transport in melanocytes. Moreover we show that, in addition to melanophilin/myosin-Va, Rab27a can recruit SPIRE1/2 to melanosomes, thereby integrating motor and track assembly activity at the organelle membrane. Based on this we suggest a model in which organelles and force generators (motors and track assemblers) are linked forming a cell-wide network that allows their collective activity to rapidly disperse the population of organelles long-distance throughout the cytoplasm.
Supply chain antecedents of agile manufacturing in a developing country context
Authors: Abdallah Ayman Bahjat , Nabass Israa Hussein 
Published: May 2018

Purpose
The purpose of this paper is to determine supply chain practices that contribute most to the success of agile manufacturing (AM), and to examine their effects on its implementation levels in the Jordanian manufacturing sector. It also investigates the effect of AM on operational performance (OP).

Design/methodology/approach
The study is based on survey data collected from 294 manufacturing companies from different industry types in Jordan. Validity and reliability analyses were performed using SPSS and AMOS, and the study hypotheses were tested using structural equation modeling.

Findings
The results revealed that supplier involvement, internal integration, and modularization of products positively and significantly affect AM. Customer involvement and postponement were insignificantly related to AM. Further, the results demonstrated that AM positively and significantly affect OP.

Originality/value
A limited number of previous studies investigated supply chain antecedents of AM. Further, there is no consensus among researchers on these practices. In addition, this area is underinvestigated in the developing countries in general and in Jordan in particular. The current study contributes to the literature by determining the most commonly linked supply chain practices to AM and examining their effects on its implementation levels in the context of a developing country, Jordan.
A game-theoretic strategic mechanism to control brand counterfeiting
Authors: Zameer Hashim , Wang Ying , Yasmeen Humaira , Mofrad Amirhossein Akhavan , Saeed Rashid 
Published: May 2018

PurposeThe purpose of this paper is to design a game theory based model that not only provide theoretical basis to control brand counterfeiting, but it also provide a mechanism to enhance brand revenue.Design/methodology/approachThis study used the dynamic game theory of incomplete information to understand and encounter the brand counterfeiting issues. The study analyzed the economic relationship of legitimate brand, counterfeiter and consumers using mixed strategy of the dynamic game theory of incomplete information.FindingsThe results have indicated that brands those take countermeasures to reduce counterfeiting earn maximum revenue, even when the legitimate brands and consumers are unaware from the actions of counterfeiting firms, the legitimate brands should take countermeasures to reduce counterfeiting to earn maximum revenue, and there exists optimal anti-counterfeiting cost for the legitimate brand. Further, this study provides theoretical basis where brand managers can decide to adopt or not to adopt anti-counterfeiting strategy, and also indicate the consequences of each decision.Practical implicationsBased upon the findings, the study put forward valuable managerial implications. The study revealed that the legitimate brand must emphasize on the significance of taking countermeasures against counterfeiter and also, brand managers should focus on making product traceable, empowering the consumer and ensuring coordination with government officials to control the counterfeiting issues.Originality/valueThis paper incorporates the role of legitimate brand, counterfeiter and a consumer to establish the dynamic game theory model using mixed strategy to understand and address the counterfeiting issues in the global market.