bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vorhofflimmern und Koronarintervention
Authors: Leschke Matthias 
Published: April 2019

ZUSAMMENFASSUNGNach den aktuellen Studiendaten von PIONEER-AF, REDUAL-PCI und der AUGUSTUS-Studie sollte bei Patienten mit Vorhofflimmern und Koronarstenting eine duale Therapie mit Rivaroxaban in der reduzierten Dosis von 15 mg oder Apixaban in der Dosis 5 mg oder Dabigatran in der Dosierung von 150 mg durchgeführt werden. In diesen 3 Studien wies die Kombination aus Rivaroxaban bzw. Dabigatran bzw. Apixaban mit Clopidogrel weitaus geringere Blutungsraten als die klassische Triple-Therapie auf. Die aktuelle ESC-Leitlinie zur Myokardrevaskularisation empfiehlt diesen dualen Therapieansatz bei im Vordergrund stehenden Blutungsrisiko mit einer Klasse IIa A. Insbesondere Patienten mit einem akuten Koronarsyndrom, die eine stärkere Plättchenaktivität mit anhaltend hoher Thrombinaktivität aufweisen, profitieren von einer verlängerten dualen Antiplättchentherapie (DAPT), wenn das Blutungsrisiko gering ist und zusätzliche ischämische Risikofaktoren, wie ein Diabetes mellitus, ein weiteres Myokardinfarktereignis, eine koronare Mehrgefäßerkrankung oder eine Niereninsuffizienz vorliegen. Der klinische Stellenwert spezieller Score-Systeme zur Differenzierung von Patienten, die von einer DAPT profitieren, ist derzeit unklar, da prospektive Daten bisher nicht vorliegen.
Multi-modality Treatment and Survival in Sinonasal Minor Salivary Gland Tumors
Authors: Torabi Sina J. , Spock Todd , Cardoso Bruno , Chao Janet , Manes R Peter , Judson Benjamin L. 
Published: April 2019

Abstract
Objectives The aim of this study was to analyze the effect of the multimodality treatment on survival in sinonasal minor salivary gland tumors.
Methods Adult clinical American Joint Committee on Cancer (AJCC) tumor (T) 1-4a staged cases of sinonasal minor salivary gland tumors were isolated from the National Cancer Database (2004–2014). Multivariate regressions were performed to analyze the effect of multimodality treatment. A subset analysis was also performed in patients with positive margins following surgical management.
Results We identified 556 cases, of which 293 (52.7%) patients were treated with surgery and radiotherapy (RT), 160 (28.8%) were treated with surgery alone, and 52 (9.4%) were treated with surgery and chemoradiotherapy (CRT). No patients were treated with chemotherapy alone. With surgery and CRT as a reference, the only treatment modality associated with decreased survival was RT alone (hazard ratio [HR]: 3.213 [95% confidence interval (CI): 1.578–6.543]; p = 0.001). Within a subset analysis of patients with positive margins, surgery was associated with decreased survival (HR: 2.021 [95% CI: 1.401–3.925]; p = 0.038), but not triple modality therapy (HR: 1.700 [95% CI: 0.798–3.662]) when compared with surgery with RT.
Conclusion The most common treatment was surgery and RT, consistent with National Comprehensive Cancer Network (NCCN) guidelines which recommends chemotherapy (CT) only in the most concerning cases. However, we found no difference in survival among most treatment modalities when compared with triple modality therapy, with the exception of RT alone. Although margins were prognostic within these cancers, we found no evidence that adjuvant CRT provides any survival benefit over surgery and RT, though surgery alone was associated with decreased survival.
Age-Specific Reference Intervals for PT, aPTT, Fibrinogen and Thrombin Time for Parturient Women
Authors: Zhang Gao-Ming , Zhang Wei , Zhang Guo-Ming 
Published: April 2019

Background Parturient women are healthy individuals who require special consideration. Parturient women are considered to be in a hyper-coagulable state. For example, the fibrinogen (FIB) levels are often higher than the upper limit of normal reference intervals (RIs) in parturient women than in non-parturient healthy individuals (2–4 g/L).
Objective The aim of this study is to establish the RIs of pro-thrombin time (PT), activated partial thromboplastin time (aPTT), FIB levels and thrombin time (TT) for parturient women.
Materials and Methods Blood levels of PT, aPTT, FIB and TT were assayed on an ACL TOP 700 automatic coagulation analyser using plasma samples from 10,472 parturient women. Outlier results were excluded by using Tukey's test. The RIs were calculated by the Clinical and Laboratory Standards Institute C28-A3 guideline.
Results The RIs of PT, aPTT, FIB and TT were 8.7 to 12.1 seconds (8.7–12.2 seconds for 16–20 years old, 8.7–12.1 second for 21–25 years old, 8.6–12.0 second for 26–30 years old, 8.7–12.0 second for 31–35 years old, 8.7–12.6 second for 36–40 years old and 8.8–12.2 second for 41 years old), 22.9 to 42.3 seconds, 1.98 to 5.82 g/L and 9.9 to 16.7 seconds, respectively. PT levels were found to be positively associated with aging.
Conclusion The above-established age-specific RIs, defined by using a large dataset, may assist clinicians in making accurate medical decisions. This was the first study in which the RIs of PT, aPTT, FIB and TT were established for parturient women in different age groups.
Expansile Traumatic Neuroma of the Intratemporal Facial Nerve
Authors: Feng Yening , Patel Neil , Burrows Anthony , Lane John , Raghunathan Aditya , Van Gompel Jamie , Carlson Matthew 
Published: April 2019

Objectives To present a rare case of traumatic facial neuroma involving the geniculate ganglion and review relevant literature.
Patient Thirty-year-old man.
Intervention Microsurgical resection via combined mastoid-middle fossa approach with great auricular nerve interpositional graft.
Main Outcome Measures Patient demographics and pre- and postoperative facial nerve function.
Results A 30-year-old man with a reported history of prior Bell's palsy developed progressive complete (House–Brackmann VI) right facial paralysis following blunt trauma. Imaging was strongly suggestive of a geniculate ganglion hemangioma. As the patient had no spontaneous improvement in his poor facial function over the course of 9 months, he underwent resection of the facial nerve lesion with great auricular nerve graft interposition via a combined mastoid-middle fossa approach. Histopathology demonstrated disorganized fascicles, with axonal clustering reminiscent of sprouting/regeneration following trauma. No cellular proliferation or vascular malformation was present.
Conclusion Traumatic facial nerve neuromas can occur following temporal bone trauma and can closely mimic primary facial nerve tumors. Akin to the management of geniculate ganglion hemangioma and schwannoma, preoperative facial function largely dictates if and when surgery should be pursued.
Assessing reproducibility of matrix factorization methods in independent transcriptomes
Authors: Cantini Laura , Kairov Ulykbek , de Reyniès Aurélien , Barillot Emmanuel , Radvanyi François , Zinovyev Andrei 
Published: April 2019

Abstract

Motivation
Matrix factorization (MF) methods are widely used in order to reduce dimensionality of transcriptomic datasets to the action of few hidden factors (metagenes). MF algorithms have never been compared based on the between-datasets reproducibility of their outputs in similar independent datasets. Lack of this knowledge might have a crucial impact when generalizing the predictions made in a study to others.

Results
We systematically test widely used MF methods on several transcriptomic datasets collected from the same cancer type (14 colorectal, 8 breast and 4 ovarian cancer transcriptomic datasets). Inspired by concepts of evolutionary bioinformatics, we design a novel framework based on Reciprocally Best Hit (RBH) graphs in order to benchmark the MF methods for their ability to produce generalizable components. We show that a particular protocol of application of independent component analysis (ICA), accompanied by a stabilization procedure, leads to a significant increase in the between-datasets reproducibility. Moreover, we show that the signals detected through this method are systematically more interpretable than those of other standard methods. We developed a user-friendly tool for performing the Stabilized ICA-based RBH meta-analysis. We apply this methodology to the study of colorectal cancer (CRC) for which 14 independent transcriptomic datasets can be collected. The resulting RBH graph maps the landscape of interconnected factors associated to biological processes or to technological artifacts. These factors can be used as clinical biomarkers or robust and tumor-type specific transcriptomic signatures of tumoral cells or tumoral microenvironment. Their intensities in different samples shed light on the mechanistic basis of CRC molecular subtyping.

Availability and implementation
The RBH construction tool is available from http://goo.gl/DzpwYp

Supplementary information
Supplementary data are available at Bioinformatics online.
Nonidentifiability in the presence of factorization for truncated data
Authors: Vakulenko-Lagun B , Qian J , Chiou S H , Betensky R A 
Published: April 2019

Summary
A time to event, $X$, is left-truncated by $T$ if $X$ can be observed only if $T<X$. This often results in oversampling of large values of $X$, and necessitates adjustment of estimation procedures to avoid bias. Simple risk-set adjustments can be made to standard risk-set-based estimators to accommodate left truncation when $T$ and $X$ are quasi-independent. We derive a weaker factorization condition for the conditional distribution of $T$ given $X$ in the observable region that permits risk-set adjustment for estimation of the distribution of $X$, but not of the distribution of $T$. Quasi-independence results when the analogous factorization condition for $X$ given $T$ holds also, in which case the distributions of $X$ and $T$ are easily estimated. While we can test for factorization, if the test does not reject, we cannot identify which factorization condition holds, or whether quasi-independence holds. Hence we require an unverifiable assumption in order to estimate the distribution of $X$ or $T$ based on truncated data. This contrasts with the common understanding that truncation is different from censoring in requiring no unverifiable assumptions for estimation. We illustrate these concepts through a simulation of left-truncated and right-censored data.
Double vascular ring: a case report of double aortic arch and concurrent pulmonary artery sling
Authors: Matsumoto Yoshimi , Kamada Masahiro , Nakagawa Naomi , Ishiguchi Yukiko 
Published: April 2019

Abstract

Background
Double aortic arch (DAA) and pulmonary artery sling (PAS) are vascular ring formations that present in neonates and infants with symptoms of respiratory stenosis.

Case summary
The patient was a girl with suspected ventricular septal defect (VSD), right aortic arch (AA), left patent ductus arteriosus, and bilateral superior vena cava (SVC) on foetal echography in the first day of life. The girl was delivered at 40 weeks and 4 days of gestation. Ventricular septal defect, DAA, coarctation of the left AA, and bilateral SVC were diagnosed. Contrast-enhanced computed tomography at Day 16 revealed PAS with concurrent anomalous tracheal branching in addition to DAA. The right A2 segmental artery, which supplies the right upper pulmonary artery, showed abnormal branching from the left pulmonary artery (LPA). At 3 months of age, VSD patching, left AA resection distal to the root of the left subclavian artery, arterial ligament dissection, and LPA replacement were performed.

Discussion
Pulmonary artery sling coexists with anomalous branching of the trachea and abnormal branching of the right pulmonary artery (RPA). Our patient had an extremely rare case of DAA concurrent with PAS and presented with anomalous tracheal and RPA branching. We were concerned that increased pulmonary blood flow caused by the VSD would exacerbate tracheal displacement. Radical surgery at 3 months of age resulted in good postoperative progress.
A place for taxonomic profiling in the study of the coral prokaryotic microbiome
Authors: Hernandez-Agreda Alejandra , Leggat William , Ainsworth Tracy D 
Published: April 2019

ABSTRACT
The enormous variability in richness, abundance and diversity of unknown bacterial organisms inhabiting the coral microbiome have challenged our understanding of their functional contribution to coral health. Identifying the attributes of the healthy meta-organism is paramount for contemporary approaches aiming to manipulate dysbiotic stages of the coral microbiome. This review evaluates the current knowledge on the structure and mechanisms driving bacterial communities in the coral microbiome and discusses two topics requiring further research to define the healthy coral microbiome. (i) We examine the necessity to establish microbial baselines to understand the spatial and temporal dynamics of the healthy coral microbiome and summarise conceptual and logistic challenges to consider in the design of these baselines. (ii) We propose potential mechanical, physical and chemical mechanisms driving bacterial distribution within coral compartments and suggest experiments to test them. Finally, we highlight aspects of the use of 16S amplicon sequencing requiring standardization and discuss its contribution to other multi-omics approaches.
The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans
Authors: Chudzicka-Ormaniec Patrycja , Macios Maria , Koper Michał , Weedall Gareth D , Caddick Mark X , Weglenski Piotr , Dzikowska Agnieszka 
Published: April 2019

ABSTRACT
In Aspergillus nidulans, nitrogen and carbon metabolism are under the control of wide-domain regulatory systems, including nitrogen metabolite repression, carbon catabolite repression and the nutrient starvation response. Transcriptomic analysis of the wild type strain grown under different combinations of carbon and nitrogen regimes was performed, to identify differentially regulated genes. Carbon metabolism predominates as the most important regulatory signal but for many genes, both carbon and nitrogen metabolisms coordinate regulation. To identify mechanisms coordinating nitrogen and carbon metabolism, we tested the role of AreB, previously identified as a regulator of genes involved in nitrogen metabolism. Deletion of areB has significant phenotypic effects on the utilization of specific carbon sources, confirming its role in the regulation of carbon metabolism. AreB was shown to regulate the expression of areA, tamA, creA, xprG and cpcA regulatory genes suggesting areB has a range of indirect, regulatory effects. Different isoforms of AreB are produced as a result of differential splicing and use of two promoters which are differentially regulated by carbon and nitrogen conditions. These isoforms are likely to be functionally distinct and thus contributing to the modulation of AreB activity.
The Role of Early Biologic Therapy in Inflammatory Bowel Disease
Authors: Berg Dana Rachel , Colombel Jean-Frederic , Ungaro Ryan 
Published: April 2019

Abstract
The goals for treatment of inflammatory bowel diseases (IBDs) are changing from elimination of symptoms toward complete disease control—a process that demands both clinical and endoscopic remission. This new IBD treatment paradigm has been shifting from a conventional “step-up” approach toward a more “top-down” early intervention treatment strategy. Recent studies suggest that the use of biologic agents, specifically those targeting tumor necrosis factor alpha, earlier in the treatment course improves patient outcomes and can prevent progression to irreversible bowel damage. Although the strategy of early intervention has accumulating evidence in Crohn’s disease, there is less evidence supporting its impact in ulcerative colitis.
Responses of seaweeds that use CO2 as their sole inorganic carbon source to ocean acidification: differential effects of fluctuating pH but little benefit of CO2 enrichment
Authors: Britton Damon , Mundy Craig N , McGraw Christina M , Revill Andrew T , Hurd Catriona L 
Published: April 2019

AbstractLaboratory studies that test the responses of coastal organisms to ocean acidification (OA) typically use constant pH regimes which do not reflect coastal systems, such as seaweed beds, where pH fluctuates on diel cycles. Seaweeds that use CO2 as their sole inorganic carbon source (non-carbon dioxide concentrating mechanism species) are predicted to benefit from OA as concentrations of dissolved CO2 increase, yet this prediction has rarely been tested, and no studies have tested the effect of pH fluctuations on non-CCM seaweeds. We conducted a laboratory experiment in which two ecologically dominant non-CCM red seaweeds (Callophyllis lambertii and Plocamium dilatatum) were exposed to four pH treatments: two static, pHT 8.0 and 7.7 and two fluctuating, pHT 8.0 ± 0.3 and 7.7 ± 0.3. Fluctuating pH reduced growth and net photosynthesis in C. lambertii, while P. dilatatum was unaffected. OA did not benefit P. dilatatum, while C. lambertii displayed elevated net photosynthetic rates. We provide evidence that carbon uptake strategy alone cannot be used as a predictor of seaweed responses to OA and highlight the importance of species-specific sensitivity to [H+]. We also emphasize the importance of including realistic pH fluctuations in experimental studies on coastal organisms.
The Distribution of Consumption Expenditure in Sub-Saharan Africa: The Inequality Among All Africans
Authors: Jirasavetakul La-Bhus Fah , Lakner Christoph 
Published: April 2019

Abstract
This paper uses a set of national household surveys to study the regional Sub-Saharan Africa distribution of consumption expenditure among individuals during 1993–2008. The analysis puts the disparities in living standards that exist among all persons in Africa into context with the disparities that exist within and between African countries. We find some evidence that African interpersonal inequality has increased, but this depends on the measure of inequality. The Africa-wide Gini increased from 53% in 1993 to 56% in 2008 in the full sample, compared with an increase from 54% to 56% in the balanced sample of countries. In the full sample, this result is robust to alternative measures of inequality, while in the balanced sample, some bottom-sensitive measures show a decline. Disparities in living standards between countries have increased, while there has been no systematic increase in within-country inequality. For the Africa-wide distribution, the growth of consumption expenditure (from household surveys) has been low (between 0.9% and 1.6% per year depending on the sample). This growth has been uneven such that the richest 5% of Africans received around 40% of the total gains.
Is research on patient portals attuned to health equity? A scoping review
Authors: Antonio Marcy G , Petrovskaya Olga , Lau Francis 
Published: April 2019

Abstract

Objective
Our scoping review examined how research on patient portals addresses health equity. Questions guiding our review were: 1) What health equity concepts are addressed in patient portal research—both explicitly and implicitly? 2) What are the gaps? 3) Is the potential for ehealth-related health inequities explicitly acknowledged in studies on patient portals? 4) What novel approaches and interventions to reduce health inequities are tested in patient portal research?

Materials and Methods
We searched 4 databases. Search terms included “patient portal” in combination with a comprehensive list of health equity terms relevant in ehealth context. Authors independently reviewed the papers during initial screening and full-text review. We applied the eHealth Equity Framework to develop search terms and analyze the included studies.

Results
Based on eHealth Equity Framework categories, the main findings generated from 65 reviewed papers were governance structures, ehealth policies, and cultural and societal values may further inequities; social position of providers and patients introduces differential preferences in portal use; equitable portal implementation can be supported through diverse user-centered design; and intermediary strategies are typically recommended to encourage portal use across populations.

Discussion
The predominant focus on barriers in portal use may be inadvertently placing individual responsibility in addressing these barriers on patients already experiencing the greatest health disparities. This approach may mask the impact of the socio-technical-economic-political context on outcomes for different populations.

Conclusion
To support equitable health outcomes related to patient portals we need to look beyond intermediary initiatives and develop equitable strategies across policy, practice, research, and implementation.
Age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration
Authors: Kim Soo Hyeon , Shishido Yuji , Sogabe Hirofumi , Rachadech Wanitcha , Yorita Kazuko , Kato Yusuke , Fukui Kiyoshi 
Published: April 2019

AbstractD-amino acid oxidase (DAO) is a flavoenzyme, catalysing oxidative deamination of D-amino acids to produce corresponding α-keto acids, ammonia and hydrogen peroxide. In our search for DAO activity among various tissues, we developed a sensitive assay based on hydrogen peroxide production involving enzyme-coupled colorimetric assay with peroxidase. We first optimized buffer components to extract DAO protein from mouse tissues. Here we show that DAO activity was detected in kidney, cerebellum, medulla oblongata, midbrain and spinal cord, but not in liver. In addition, we observed that DAO activity and expression were decreased in thoracic and lumbar regions of spinal cord in aged mice when compared with young mice, indicating that decreased DAO is involved in motoneuron degeneration during senescence. We also found gender difference in DAO activity in the kidney, suggesting that DAO activity is influenced by sexual dimorphism. We newly detected DAO activity in the epididymis, although undetected in testis. Furthermore, DAO activity was significantly higher in the caput region than corpus and cauda regions of epididymis, indicating that D-amino acids present in the testis are eliminated in epididymis. Taken together, age- and gender-dependent DAO activity in each organ may underlie the human pathophysiology regulated by D-amino acid metabolism.
Life Table Parameters of the Zoophytophagous Predator Brontocoris tabidus (Heteroptera: Pentatomidae) on Introduced and Native Plants
Authors: de Medeiros Rômulo Sátiro , Vinha Germano Lopes , Zanuncio José Cola , Wilcken Carlos Frederico , de Menezes Claubert Wagner Guimarães , Soares Marcus Alvarenga , Carvalho Amélia Guimarães 
Published: April 2019

AbstractBrontocoris tabidus Signoret (Heteroptera: Pentatomidae) is a zoophytophagous predator of lepidopteran defoliators of eucalyptus in Brazil. This predator complements its diet with plants, which is fundamental for its population maintenance. The objective was to evaluate the B. tabidus development, reproduction, and life table parameters in the field on Eucalyptus cloeziana F. Muell. (T1), Psidium guajava Linn (Myrtales: Myrtaceae) (T2), or without plants (T3). The parameters estimated were: net reproductive rate (Ro); generation duration (DG); time for the population to double in size (TD); intrinsic population growth rate (rm), survival rate (lX), specific fertility (mx), life expectancy (ex), and mortality risk (qx). Ro, DG, TD, and rm were higher in the T1 and T2 than in T3. Plant presence favored the lx, mx, and qx. Ex values were 36.1 and 56.9 in the T3 and T1, respectively. The B. tabidus fertility, longevity, and life table parameters improvement on E. cloeziana and P. guajava plants are due to the water and nutrients obtained from them. B. tabidus can be reared with Tenebrio molitor Linnaeus (Coleoptara: Tenebrionidae) pupae on E. cloeziana or P. guajava plants in the field.