bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Electronic Cigarettes on the Inner Mucosa of the Craniofacial Region
Authors: Kar Murat , Emre Ismet Emrah , Bayar Muluk Nuray , Cingi Cemal 
Published: February 2019

Objectives:
The aim of this paper is to investigate electronic cigarettes (e-cigarettes) from the otorhinolaryngologic point of view.

Methods:
The authors searched Central Database of Kirikkale University Library, Google, PubMed, and Proquest and Google Scholar.

Results:
An electronic cigarette or e-cigarette is a battery-powered device that vaporizes a liquid, generally including nicotine. Nowadays, e-cigarettes are used for smoking cessation or to reduce the consumption of conventional tobacco cigarettes. First generation e-cigarette devices were similar to conventional tobacco cigarettes in terms of shape and size and expressed as “cigalikes.” Differently from traditional cigarettes in which tobacco is burned to generate smoke, electronic cigarettes contain a tank filled with liquid. It was found that e-cigarette liquids contained different types of chemical compounds which were either previously known carcinogens or probably prove to be carcinogenic to humans in the near future. It seems that the use of electronic cigarette does not harm the oral cells. However, the use of e-cigarette for 4 weeks led to metaplasia and hyperplasia of the laryngeal mucosa in rats. Furthermore, e-ciagarettes produce some adverse effects on the nasal mucosa, supressing the immune system.

Conclusion:
It should not be considered that e-cigarettes are safer unless their effects on the mucosa of the ear, nose, and throat are more precisely clarified.
Allergic Epidural Effusion Following Polyetheretherketone Cranioplasty
Authors: Qiu Shenzhong , You Wendong , Wang Hao , Zhou Xi , Yang Xiaofeng 
Published: February 2019

Abstract
Cranioplasty is a common procedure in neurosurgical practice. However, some complications may occur after the operation. We here presented a case of bilateral skull defect and underwent cranioplasty with polyetheretherketone (PEEK) prosthesis. The patient developed epidural effusion on both sides 7 days after surgery. The effusion was light yellow and transparent, and laboratory examinations revealed normal glucose level, negative bacteriological results, and increased IgG protein concentration. The effusion disappeared after treatment with dexamethasone and drainage. We speculated that the epidural effusion was because of delayed type allergic reactions after PEEK cranioplasty. However, further studies are needed to investigate its related mechanisms.
Donor Plasma Mitochondrial DNA Is Correlated with Posttransplant Renal Allograft Function
Authors: Han Fei , Wan Shaogui , Sun Qipeng , Chen Nan , Li Heng , Zheng Lingling , Zhang Nana , Huang Zhengyu , Hong Liangqing , Sun Qiquan 
Published: February 2019

Background.
The lack of accurate biomarkers makes it difficult to determine whether organs are suitable for transplantation. Mitochondrial DNA (mtDNA) correlates with tissue damage and kidney disease, making it a potential biomarker in organ evaluation.

Methods.
Donors who had experienced cardiac death and successfully donated their kidneys between January 2015 and May 2017 were included this study. We detected the level of mtDNA in the plasma of the donor using quantitative real-time polymerase chain reaction and then statistically analyzed the relationship between the level of mtDNA and the delayed graft function (DGF) of the recipient.

Results.
The incidence of DGF or slowed graft function (SGF) increased by 4 times (68% versus 16%, P < 0.001) when the donor mtDNA (dmtDNA) level was >0.114. When dmtDNA levels were >0.243, DGF and primary nonfunction were approximately 100% and 44%, respectively. Moreover, dmtDNA was an independent risk factor for slowed graft function and DGF. A prediction model for DGF based on dmtDNA achieved an area under the receiver operating characteristic curve for a prediction score as high as 0.930 (95% confidence interval 0.856-1.000), and the validation cohort results showed that the sensitivity and specificity of the model were 100% and 78%, respectively. dmtDNA levels were correlated with 6-month allograft function (R
2=0.332, P < 0.001) and 1-year graft survival (79% versus 99%, P < 0.001).

Conclusions.
We conclusively demonstrated that plasma dmtDNA was an independent risk factor for DGF, which is valuable in organ evaluation. dmtDNA is a possible first predictive marker for primary nonfunction and worth further evaluation.
Do Most Patients With a Spontaneous Cerebrospinal Fluid Leak Have Idiopathic Intracranial Hypertension?
Authors: Bidot Samuel , Levy Joshua M. , Saindane Amit M. , Oyesiku Nelson M. , Newman Nancy J. , Biousse Valérie 
Published: February 2019

Background:
The association between cerebrospinal fluid (CSF) leaks at the skull base and raised intracranial pressure (ICP) has been reported since the 1960s. It has been suggested that spontaneous CSF leaks might represent a variant of idiopathic intracranial hypertension (IIH). We review the evidence regarding the association between spontaneous CSF leaks and IIH, and the role of ICP in the pathophysiology of nontraumatic skull base defects. We also discuss the management of ICP in the setting of CSF leaks and IIH.

Evidence Acquisition:
References were identified by searches of PubMed from 1955 to September 2018 with the terms “idiopathic intracranial hypertension” and “cerebrospinal fluid leak.” Additional references were identified using the terms “pseudotumor cerebri,” “intracranial hypertension,” “benign intracranial hypertension,” and by hand search of relevant articles.

Results:
A CSF leak entails the egress of CSF from the subarachnoid spaces of the skull base into the surrounding cavitary structures. Striking overlaps exist regarding demographic, clinical, and radiological characteristics between IIH patients and those with spontaneous CSF leaks, suggesting that some (if not most) of these patients have IIH. However, determining whether a patient with spontaneous CSF leak may have IIH may be difficult, as signs and symptoms of raised ICP may be obviated by the leak. The pathophysiology is unknown but might stem from progressive erosion of the thin bone of the skull base by persistent pulsatile high CSF pressure. Currently, there is no consensus regarding the management of ICP after spontaneous CSF leak repair when IIH is suspected.

Conclusions:
IIH is becoming more widely recognized as a cause of spontaneous CSF leaks, but the causal relationship remains poorly characterized. Systematic evaluation and follow-up of patients with spontaneous CSF leaks by neuro-ophthalmologists will help clarify the relation between IIH and spontaneous CSF leaks.
Future state prediction errors guide active avoidance behavior by adult zebrafish
Authors: Torigoe Makio , Islam Tanvir , Kakinuma Hisaya , Fung Chi Chung Alan , Isomura Takuya , Shimazaki Hideaki , Aoki Tazu , Fukai Tomoki , Okamoto Hitoshi 
Published: February 2019

SummaryHuman predicts future. To ask if fish also has this capacity, we established the virtual reality training system with live imaging of the telencephalic neurons of adult zebrafish in the active avoidance and found that, at the onset of the trial, learned fish conceives two future conditions as the favorable status on its way to the safe goal, i.e. one with the backwardly moving landscape and the other with the color of the safe goal. And the two different neural ensembles monitor the discrepancy between these predictions and the perceived real external status. Once fish reaches the goal, another ensemble is set to work to monitor whether fish keeps staying in the safe goal. The manipulation to artificially enhance these prediction errors elevated the activities of these ensembles and induced fish to behave to correct errors, revealing that fish sets behavioral strategy to actively realize these predictions.
Predictive neural processing in adult zebrafish depends on shank3b
Authors: Huang Kuo‐Hua , Rupprecht Peter , Schebesta Michael , Serluca Fabrizio , Kitamura Kyohei , Bouwmeester Tewis , Friedrich Rainer W. 
Published: February 2019

SummaryIntelligent behavior requires a comparison between the predicted and the actual consequences of behavioral actions. According to the theory of predictive processing, this comparison relies on a neuronal error signal that reflects the mismatch between an internal prediction and sensory input. Inappropriate error signals may generate pathological experiences in neuropsychiatric conditions. To examine the processing of sensorimotor prediction errors across different telencephalic brain areas we optically measured neuronal activity in head-fixed, adult zebrafish in a virtual reality. Brief perturbations of visuomotor feedback triggered distinct changes in swimming behavior and different neuronal responses. Neuronal activity reflecting sensorimotor mismatch, rather than sensory input or motor output alone, was prominent throughout multiple forebrain areas. This activity preceded and predicted the transition in motor behavior. Error signals were altered in specific forebrain regions by a mutation in the autism-related gene shank3b. Predictive processing is therefore a widespread phenomenon that may contribute to disease phenotypes.
GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors
Authors: Sriram Krishna , Moyung Kevin , Corriden Ross , Carter Hannah , Insel Paul A. 
Published: February 2019

AbstractG protein-coupled receptors (GPCRs) are the most widely targeted gene family for FDA-approved drugs. To assess possible roles for GPCRs in cancer, we analyzed Cancer Genome Atlas data for mRNA expression, mutations, and copy number variation (CNV) in 20 categories/45 sub-types of solid tumors and quantified differential expression of GPCRs by comparing tumors against normal tissue from the GTEx database. GPCRs are over-represented among coding genes with elevated expression in solid tumors; most tumor types differentially express >50 GPCRs, including many targets for approved drugs, hitherto largely unrecognized as targets of interest in cancer. GPCR mRNA signatures characterize specific tumor types, indicate survival and correlate with expression of cancer-related pathways. Tumor GPCR mRNA signatures have prognostic relevance for survival and correlate with expression of numerous cancer-related genes and pathways. GPCR expression in tumors is largely independent of staging/grading/metastasis/driver mutations and GPCRs expressed in cancer cell lines parallels that measured in tumors. Certain GPCRs are frequently mutated and appear to be hotspots, serving as bellwethers of accumulated genomic damage. CNV of GPCRs while common, does not generally correlate with mRNA expression. We suggest a previously under-appreciated role for GPCRs in cancer, perhaps as functional oncogenes, biomarkers, surface antigens and pharmacological targets.
LAB–QA2GO: A free, easy-to-use toolbox for the quality assessment of magnetic resonance imaging data
Authors: Vogelbacher Christoph , Bopp Miriam H. A. , Schuster Verena , Herholz Peer , Jansen Andreas , Sommer Jens 
Published: February 2019

AbstractImage characteristics of magnetic resonance imaging (MRI) data (e.g. signal-to-noise ratio, SNR) may change over the course of a study. To monitor these changes a quality assurance (QA) protocol is necessary. QA can be realized both by performing regular phantom measurements and by controlling the human MRI datasets (e.g. noise detection in structural or movement parameters in functional datasets). Several QA tools for the assessment of MRI data quality have been developed. Many of them are freely available. This allows in principle the flexible set-up of a QA protocol specifically adapted to the aims of one’s own study.However, setup and maintenance of these tools bind time, in particular since the installation and operation often require a fair amount of technical knowledge. In this article we present a light-weighted virtual machine, named LAB-QA2GO, which provides scripts for fully automated QA analyses of phantom and human datasets. This virtual machine is ready for analysis by starting it the first time. With minimal configuration in the guided web-interface the first analysis can start within 10 minutes, while adapting to local phantoms and needs is easily possible. The usability and scope of LAB–QA2GO is illustrated using a data set from the QA protocol of our lab. With LAB–QA2GO we hope to provide an easy-to-use toolbox that is able to calculate QA statistics without high effort.
Disentangling semantic and response learning effects in color-word contingency learning
Authors: Geukes Sebastian , Vorberg Dirk , Zwitserlood Pienie 
Published: February 2019

AbstractIt is easier to indicate the ink color of a color-neutral noun when it is presented in the color in which it had been shown frequently before, relative to print colors in which it had been shown less often. This phenomenon is known as color-word-contingency learning. It remains unclear whether participants actually learn semantic (word-color) associations or/and response (word-button) associations. We here present a novel variant of the paradigm that can disentangle semantic and response learning, because word-color and word-button associations are manipulated independently. In four experiments, each involving four daily sessions, novel words (pseudowords such as enas, fatu or imot) were probabilistically associated either with a particular color, a particular response-button position, or with both. Neutral trials were also included, and participants’ awareness of the contingencies was manipulated. The data showed no impact of explicit contingency awareness, but clear evidence both for response learning and for semantic learning, with effects emerging swiftly. Deeper processing of color information, with color words presented in black instead of color patches to indicate response-button positions, resulted in stronger effects, both for semantic and response learning. Our data add a crucial piece of evidence lacking so far in color-word contingency learning studies: Semantic learning effectively takes place even when associations are learned in an incidental way.
Reclamation is not the primary determinant of soil recovery from oil and gas development in Wyoming sagebrush systems
Authors: Rottler Caitlin M. , Burke Ingrid C. , Lauenroth William K. 
Published: February 2019

AbstractDryland soils store approximately 10-15% of the world’s soil organic matter (SOM) to 1 m. Threats to carbon stocks in global dryland soils include cultivation, overgrazing, urbanization, and energy development. To limit loss of carbon from these soils, it is important to understand, first, how disturbances affect SOM and second, how SOM recovers after disturbance. In this study, we address current gaps in our understanding of the effects of oil and gas development and reclamation on SOM in the sagebrush steppe of Wyoming, a cold temperate shrub-dominated dryland. Most studies have found that soil disturbance, including from the respreading of topsoil during wellpad reclamation, is damaging to SOM stores; however, research on ~80 year old unreclaimed oil and gas wellpads found no difference in SOM between wellpads and undisturbed sites. Using a chronosequence approach and paired study design, we evaluated the effects of reclamation on SOM by comparing undisturbed sites to wellpads where reclamation activities either had or had not occurred. Our results suggest that the most important factor in recovery of SOM after disturbance in this area was not the presence or absence of reclamation, but time since wellpad abandonment and spatial heterogeneity of plants. Further study on the effectiveness of different reclamation techniques is warranted if the goal of reclamation is to aid SOM recovery and prevent further C loss from these systems.
Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices
Authors: Racioppi Claudia , Wiechecki Keira A , Christiaen Lionel 
Published: February 2019

ABSTRACTIn embryos, lineage-specific profiles of chromatin accessibility control gene expression by modulating transcription, and thus impact multipotent progenitor states and subsequent fate choices. Subsets of cardiac and pharyngeal/head muscles share a common origin in the cardiopharyngeal mesoderm, but the chromatin landscapes that govern multipotent progenitors’ competence and early fate choices remain largely elusive. Here, we leveraged the simplicity of the chordate modelCionato profile chromatin accessibility through stereotyped transitions from naiveMesp+ mesoderm to distinct fate-restricted heart and pharyngeal muscle precursors. An FGF-Foxf pathway acts in multipotent progenitors to establish cardiopharyngeal-specific patterns of accessibility, which govern later heart vs. pharyngeal muscle-specific expression profiles, demonstrating extensive spatiotemporal decoupling between early cardiopharyngeal enhancer accessibility and late cell-type-specific activity. Combinations ofcis-regulatory elements with distinct chromatin accessibility profiles are required to activate ofEbfandTbx1/10, two key determinants of cardiopharyngeal fate choices. We propose that this higher order combinatorial logic increases the repertoire of regulatory inputs that control gene expression, through either accessibility and/or activity, thus fostering spatially and temporally accurate fate choices.
Stable Pom1 clusters form a glucose-modulated concentration gradient that regulates mitotic entry
Authors: Allard Corey A.H. , Opalko Hannah E. , Moseley James B. 
Published: February 2019

AbstractControl of cell size requires molecular size sensors that are coupled to the cell cycle. Rod-shaped fission yeast cells divide at a threshold size partly due to Cdr2 kinase, which forms nodes at the medial cell cortex where it inhibits the Cdk1-inhibitor Wee1. Pom1 kinase phosphorylates and inhibits Cdr2, and forms cortical concentration gradients from cell poles. Pom1 inhibits Cdr2 signaling to Wee1 specifically in small cells, but the time and place of their regulatory interactions were unclear. We show that Pom1 forms stable oligomeric puncta that dynamically sample the cell cortex. Binding frequency is patterned into a concentration gradient by the polarity landmarks Tea1 and Tea4. Pom1 puncta colocalize with Cdr2 nodes, forming a glucose-modulated inhibitory threshold against node activation. Our work reveals how Pom1-Cdr2-Wee1 operates in multiprotein clusters at the cell cortex to promote mitotic entry at a specific size that can be modified by nutrient availability.
Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the Gβ subunit
Authors: Tsai Ching-Ju , Marino Jacopo , Adaixo Ricardo J. , Pamula Filip , Mühle Jonas , Maeda Shoji , Flock Tilman , Taylor Nicholas M.I. , Mohammed Inayatulla , Matile Hugues , Dawson Roger J. P. , Deupi Xavier , Stahlberg Henning , Schertler Gebhard F. X. 
Published: February 2019

AbstractG protein-coupled receptors (GPCRs) are the largest class of integral membrane proteins and represent key targets for pharmacological research. GPCRs modulate cell physiology by engaging and activating a diversity of intracellular transducers, prominently heterotrimeric G proteins, but also G protein-receptor kinases (GRKs) and arrestins. The recent surge in the number of structures of GPCR-G protein complexes has expanded our understanding of G protein recognition and GPCR-mediated signal transduction. However, many aspects of these mechanisms, including the existence of transient interactions with transducers, have remained elusive.Here, we present the cryo-EM structure of the light-sensitive GPCR rhodopsin in complex with heterotrimeric Gi. In contrast to all reported structures, our density map reveals the receptor C-terminal tail bound to the Gβ subunit of the G protein heterotrimer. This observation provides a structural foundation for the role of the C-terminal tail in GPCR signaling, and of Gβ as scaffold for recruiting Gα subunits and GRKs. By comparing all available complex structures, we found a small set of common anchoring points that are G protein-subtype specific. Taken together, our structure and analysis provide new structural basis for the molecular events of the GPCR signaling pathway.
From health to performance
Authors: Feng Yuanyuan , Agosto Denise E. 
Published: February 2019

PurposeBuilding on theoretical foundation of personal information management (PIM) in information science, this paper seeks to understand how activity tracker users manage their personal health information generated by their devices and to elucidate future activity tracking technology in support of personal health information management (PHIM). This paper aims to discuss this issue.Design/methodology/approachThe authors conducted a web survey study with a specific group of activity tracker users – amateur runners. This survey collected both quantitative and qualitative data on participants’ engagement with activity tracking technology, their PHIM practices with the information generated by the technology and how their needs were being met by their activity tracking technology use and PHIM practices.FindingsAmateur runners surveyed in this study exhibit long-term engagement and frequent interaction with activity tracking technology. They also engage in PHIM practices by using a range of PHIM tools and performing various PHIM activities. Furthermore, they use activity tracking technology and engage in PHIM practices to meet various health/fitness-related needs and information needs, while some of these needs such as performance needs and overarching needs are only partially met or unmet.Originality/valueThis research discusses amateur runners as power users of activity tracking technology, provides timely updates to PIM and PHIM research in light of a new type of personal health information, and generates design considerations for future activity tracking technology in support of PHIM. It also brings together previously disparate research regarding everyday life PHIM in information science, human–computer interaction and health informatics.
“When you write review” matters
Authors: Li Hengyun , Zhang Zili , Meng Fang , Zhang Ziqiong 
Published: February 2019

PurposeThis study aims to investigate how prior reviews posted by other consumers affect subsequent consumers’ evaluations and to what extent the review temporal distance can increase or reduce the social influence of prior reviews. In this study’s restaurant context, review temporal distance refers to the duration between dining time and review time of a dining experience.Design/methodology/approachThe data of paired online restaurant reservations and reviews are analyzed using Ordered Logit Model. Two robustness checks are conducted to test the stability of the main estimation results.FindingsThe empirical results demonstrate that consumers’ restaurant evaluation is socially influenced by both the prior average review rating and number of prior reviews; review temporal distance has a direct negative effect on consumers’ restaurant evaluation; and review temporal distance increases the social influence of prior reviews.Practical implicationsThis study suggests that online review matters. Both restaurants and the online review platforms should encourage consumers to share their experiences and post online reviews immediately after their consumption.Originality/valueThe study contributes to the literature on electronic word-of-mouth, social influence and psychological distance. First, the bi-directional nature of social influence on electronic word-of-mouth for experience-oriented product is documented. Second, for the first time, this study examines how review temporal distance could affect the social influence on consumers’ restaurant evaluation.