bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detailed Analysis of the Crystal Structures and Magnetic Properties of a Dysprosium(III) Phthalocyaninato Sextuple‐Decker Complex: Weak f–f Interactions Suppress Magnetic Relaxation
Authors: Horii Yoji , Katoh Keiichi , Sugimoto Kunihisa , Nakanishi Ryo , Breedlove Brian K. , Yamashita Masahiro 
Published: January 2019

AbstractIn the research field of single‐molecule magnets (SMMs), lanthanoid–lanthanoid interactions, so‐called f–f interactions, are known to affect the SMM properties, although their magnitudes are small. In this article, an SMM with very weak f–f interactions is reported, and the effects of the interactions on the SMM properties are discussed. X‐ray structural analysis of the DyIII‐CdII‐phthalocyaninato sextuple‐decker complex (Dy2Cd3) reveals that the intramolecular Dy−Dy length in Dy2Cd3 is more than 13 Å, which is longer than the intermolecular Dy−Dy length. Even though the two DyIII ions are far apart, intermolecular ferromagnetic dipole–dipole interactions are observed in Dy2Cd3. From detailed analysis of ac magnetic susceptibilities, quantum tunneling of the magnetization (QTM) in Dy2Cd3 is partially suppressed owing to the existence of very weak Dy−Dy interactions. Our results show that even very weak Dy−Dy interactions act as a dipolar bias, suppressing QTM.
Ligand Exchange Strategy for Tuning of Helicity Inversion Speeds of Dynamic Helical Tri(saloph) Metallocryptands
Authors: Sakata Yoko , Chiba Shunsuke , Miyashita Masato , Nabeshima Tatsuya , Akine Shigehisa 
Published: January 2019

AbstractWe developed a new strategy, ligand exchange strategy, for tuning the response speeds of helicity inversion of a metal‐containing helical structure. This is based on the exchange of the two axial amine ligands of the octahedral Co3+ centers in the metallocryptands [LCo3X6] (X=axial amine ligand). The response speeds of the helicity induction were controlled by using different combinations of achiral and chiral amines as the starting and entering ligands, respectively. The response speeds of the helicity inversion from P to M were also tuned by using different combinations of chiral amines.
Mass Spectrometric Identification of [4Fe–4S](NO)x Intermediates of Nitric Oxide Sensing by Regulatory Iron–Sulfur Cluster Proteins
Authors: Crack Jason C. , Le Brun Nick E. 
Published: January 2019

AbstractNitric oxide (NO) can function as both a cytotoxin and a signalling molecule. In both cases, reaction with iron–sulfur (Fe–S) cluster proteins plays an important role because Fe–S clusters are reactive towards NO and so are a primary site of general NO‐induced damage (toxicity). This sensitivity to nitrosylation is harnessed in the growing group of regulatory proteins that function in sensing of NO via an Fe–S cluster. Although information about the products of cluster nitrosylation is now emerging, detection and identification of intermediates remains a major challenge, due to their transient nature and the difficulty in distinguishing spectroscopically similar iron‐NO species. Here we report studies of the NO‐sensing Fe–S cluster regulators NsrR and WhiD using non‐denaturing mass spectrometry, in which non‐covalent interactions between the protein and Fe/S/NO species are preserved. The data provide remarkable insight into the nitrosylation reactions, permitting identification, for the first time, of protein‐bound mono‐, di‐ and tetranitrosyl [4Fe–4S] cluster complexes ([4Fe–4S](NO), [4Fe–4S])(NO)2 and [4Fe–4S](NO)4) as intermediates along pathways to formation of product Roussin's red ester (RRE) and Roussin's black salt (RBS)‐like species. The data allow the nitrosylation mechanisms of NsrR and WhiD to be elucidated and clearly distinguished.
B, N Co‐Doped Three‐Dimensional Carbon Aerogels with Excellent Electrochemical Performance for the Oxygen Reduction Reaction
Authors: Yu Jie , Wang Congliang , Yuan Wenjing , Shen Yuhua , Xie Anjian 
Published: January 2019

AbstractHerein, an ordinary and mass‐production approach is reported to synthesize boron (B) and nitrogen (N) co‐doped three‐dimensional (3D) carbon aerogels (CA) by using glucose and borax as the raw materials by a simple hydrothermal method and then carbonization in NH3 atmosphere. The porous material (BN‐CA‐900) possesses a large specific surface area (1032 m2 g−1) and high contents of doped pyridinic N and graphitic N. The onset potential (0.91 V vs. reversible hydrogen electrode, RHE), half‐wave potential (0.77 V vs. RHE), and current density (5.70 mA cm−2 at 0.2 V vs. RHE) of BN‐CA‐900 for ORR are similar to those of commercial Pt/C, indicating that BN‐CA‐900 has a comparable catalytic activity with Pt/C in alkaline media. The number of electron transfer is 3.86–3.99 and the yield of hydrogen peroxide is less than 6.8 %. BN‐CA‐900 also presents decent catalytic performance in acidic medium. Moreover, the stability and methanol tolerance of BN‐CA‐900 are superior to commercial Pt/C in both alkaline and acidic media. The prepared BN‐CA‐900 is a promising candidate that may be applied in other areas, such as the adsorption of pollution, porous conductive electrodes, and lithium‐ion batteries.
Nickel(II)‐Catalyzed Diastereo‐ and Enantioselective [3+2] Cycloaddition of α‐Ketoesters with 2‐Nitrovinylindoles and 2‐Nitrovinylpyrroles
Authors: Yang Wu‐Lin , Sun Zhong‐Tao , Sun Hao , Deng Wei‐Ping 
Published: January 2019

Summary of main observation and conclusionThe catalytic asymmetric [3+2] cycloaddition of α‐ketoesters with 2‐nitrovinylindoles and 2‐nitrovinyl‐ pyrroles has been established. This strategy allowed the construction of structurally diverse pyrrolo[1,2‐a]indoles bearing three contiguous stereocenters in generally high yields and good to excellent stereoselectivities (up to 98% yield, > 98 : 2 dr, 99% ee). The efficient synthesis of tetracyclic psychotropic compound analogue via the derivatization of cycloadduct showed the great synthetic potential of this strategy.
Design and Synthesis of Ionic Liquid‐Based Matrix Metalloproteinase Inhibitors (MMPIs): A Simple Approach to Increase Hydrophilicity and to Develop MMPI‐Coated Gold Nanoparticles
Authors: D'Andrea Felicia , Nuti Elisa , Becherini Stefano , Cuffaro Doretta , Husanu Elena , Camodeca Caterina , De Vita Elena , Zocchi Maria Raffaella , Poggi Alessandro , D'Arrigo Cristina , Cappello Valentina , Gemmi Mauro , Nencetti Susanna , Chiappe Cinzia , Rossello Armando 
Published: January 2019

AbstractSelective and potent matrix metalloproteinase 12 (MMP‐12) inhibitors endowed with improved hydrophilicity are highly sought for potential use in the treatment of lung and cardiovascular diseases. In the present paper, we modified the structure of a nanomolar MMP‐12 inhibitor by incorporating an ionic liquid (IL) moiety to improve aqueous solubility. Four biologically active salts were obtained by linking the sulfonamide moiety of the MMP‐12 inhibitor to imidazolium‐, pyrrolidinium‐, piperidinium‐, and DABCO‐based ILs. The imidazolium‐based bioactive salt was tested on human recombinant MMPs and on monocyte‐derived dendritic cells, showing activity similar to that of the parent compound, but improved water solubility. The imidazolium‐based bioactive salt was then used to prepare electrostatically stabilized MMP inhibitor‐coated gold nanoparticles (AuNPs) able to selectively bind MMP‐12. These AuNPs were used to study subcellular localization of MMP‐12 in monocyte‐derived dendritic cells by transmission electron microscopy analysis.
Large‐scale profiling of serum metabolites in African American and European American patients with bladder cancer reveals metabolic pathways associated with patient survival
Authors: Vantaku Venkatrao , Donepudi Sri Ramya , Piyarathna Danthasinghe Waduge Badrajee , Amara Chandra Sekhar , Ambati Chandrashekar R. , Tang Wei , Putluri Vasanta , Chandrashekar Darshan S. , Varambally Sooryanarayana , Terris Martha K. , Davies Kimberly , Ambs Stefan , Bollag Roni , Apolo Andrea B. , Sreekumar Arun , Putluri Nagireddy 
Published: January 2019

BackgroundAfrican Americans (AAs) experience a disproportionally high rate of bladder cancer (BLCA) deaths even though their incidence rates are lower than those of other patient groups. Using a metabolomics approach, this study investigated how AA BLCA may differ molecularly from European Americans (EAs) BLCA, and it examined serum samples from patients with BLCA with the aim of identifying druggable metabolic pathways in AA patients.MethodsTargeted metabolomics was applied to measure more than 300 metabolites in serum samples from 2 independent cohorts of EA and AA patients with BLCA and healthy EA and AA controls via liquid chromatography–mass spectrometry, and this was followed by the identification of altered metabolic pathways with a focus on AA BLCA. A subset of the differential metabolites was validated via absolute quantification with the Biocrates AbsoluteIDQ p180 kit. The clinical significance of the findings was further examined in The Cancer Genomic Atlas BLCA data set.ResultsFifty‐three metabolites, mainly related to amino acid, lipid, and nucleotide metabolism, were identified that showed significant differences in abundance between AA and EA BLCA. For example, the levels of taurine, glutamine, glutamate, aspartate, and serine were elevated in serum samples from AA patients versus EA patients. By mapping these metabolites to genes, this study identified significant relations with regulators of metabolism such as malic enzyme 3, prolyl 3‐hydroxylase 2, and lysine demethylase 2A that predicted patient survival exclusively in AA patients with BLCA.ConclusionsThis metabolic profile of serum samples might be used to assess risk progression in AA BLCA. These first‐in‐field findings describe metabolic alterations in AA BLCA and emphasize a potential biological basis for BLCA health disparities.
Radiotherapy for retroperitoneal liposarcoma: A report from the Transatlantic Retroperitoneal Sarcoma Working Group
Authors: Haas Rick L. M. , Bonvalot Sylvie , Miceli Rosalba , Strauss Dirk C. , Swallow Carol J. , Hohenberger Peter , van Coevorden Frits , Rutkowski Piotr , Callegaro Dario , Hayes Andrew J. , Honoré Charles , Fairweather Mark , Gladdy Rebecca , Jakob Jens , Szacht Milena , Fiore Marco , Chung Peter W. , van Houdt Winan J. , Raut Chandrajit P. , Gronchi Alessandro 
Published: January 2019

AbstractBackgroundThe current study investigated the role of radiotherapy (RT) in patients with primary nonmetastatic retroperitoneal liposarcomas.MethodsA total of 607 patients with localized retroperitoneal well‐differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS) underwent surgical resection with or without RT at 8 high‐volume sarcoma centers (234 patients with WDLPS, 242 patients with grade 1 to 2 DDLPS, and 131 patients with grade 3 DDLPS; grading was performed according to the National Federation of Centers for the Fight Against Cancer [Federation Nationale des Centres de Lutte Contre le Cancer; FNCLCC]). RT was administered in 19.7%, 34.7%, and 35.1%, respectively, of these 3 cohorts. Overall survival (OS) was estimated using the Kaplan‐Meier method, and the incidences of local recurrence and distant metastasis (DM) were estimated in a competing risk framework. To account for bias consistent with nonrandom RT assignment, propensity scores were estimated. Cox univariable analysis of the association between RT and oncological endpoints was performed by applying inverse probability of treatment weighting (IPTW) using propensity scores.ResultsAge, tumor size, and the administration of chemotherapy were found to be significantly imbalanced between patients who did and did not undergo RT in all cohorts. IPTW largely removed imbalances in key prognostic variables. Although the 8‐year local recurrence incidences in patients treated with surgery plus RT versus surgery only were 11.8% and 39.2%, respectively, for patients with WDLPS (P = .011;); 29.0% and 56.7%, respectively, for patients with grade 1 to 2 DDLPS (P = .008); and 29.8% and 43.7%, respectively, for patients with grade 3 DDLPS (P = .025), this significant benefit was lost after IPTW analyses. There were no significant differences noted with regard to DM and OS between irradiated and unirradiated patients across all 3 cohorts.ConclusionsPerioperative RT was found to be associated with better local control in univariable unadjusted analysis in all 3 cohorts, but not after accounting for imbalances in prognostic variables. RT did not impact on DM or OS. The appropriate selection of RT in this disease remains challenging. The results of the European Organization for Research and Treatment of Cancer (EORTC)–Soft Tissue and Bone Sarcoma Group (STBSG) 62092‐22092 prospective randomized trial are awaited.
Serendipitous Rediscovery of the Facile Cyclization of Z,Z‐3,5‐Octadiene‐1,7‐diyne Derivatives to Afford Stable, Substituted Naphthocyclobutadienes
Authors: Barker Joshua E. , Kodama Takuya , Song Min K. , Frederickson Conerd K. , Jousselin‐Oba Tanguy , Zakharov Lev N. , Marrot Jérôme , Frigoli Michel , Johnson Richard P. , Haley Michael M. 
Published: January 2019

AbstractThe serendipitous isolation of very small amounts of two naphthocyclobutadiene (NCB) derivatives has led to the computational re‐examination of the electrocyclization of Z,Z‐3,5‐octadiene‐1,7‐diyne as well as the experimental and computational study of diethynylindeno[2,1‐a]fluorene derivatives that contain the 3,5‐octadiene‐1,7‐diyne motif as part of a larger π‐framework. In both cases the calculated potential energy surface strongly implicates two successive electrocyclic reactions to afford the antiaromatic products. With the octadienediyne fragment locked in the reactive conformation, the postulated diethynylindeno[2,1‐a]fluorene intermediates afford the NCBs in modest to good yields. X‐ray crystallography of four NCBs as well as NICS‐XY scan calculations show that the paratropic motif is located primarily in the benzocyclobutadiene fragment within the larger π‐scaffold.
A description of nesting behaviors, including factors impacting nest site selection, in black‐and‐white ruffed lemurs (Varecia variegata)
Authors: Baden Andrea L. 
Published: January 2019

AbstractNest site selection is at once fundamental to reproduction and a poorly understood component of many organisms’ reproductive investment. This study investigates the nesting behaviors of black‐and‐white ruffed lemurs,Varecia variegata, a litter‐bearing primate from the southeastern rainforests of Madagascar. Using a combination of behavioral, geospatial, and demographic data, I test the hypotheses that environmental and social cues influence nest site selection and that these decisions ultimately impact maternal reproductive success. Gestating females built multiple large nests throughout their territories. Of these, females used only a fraction of the originally constructed nests, as well as several parking locations as infants aged. Nest construction was best predicted by environmental cues, including the size of the nesting tree and density of feeding trees within a 75 m radius of the nest, whereas nest use depended largely on the size and average distance to feeding trees within that same area. Microhabitat characteristics were unrelated to whether females built or used nests. Although unrelated to nest site selection, social cues, specifically the average distance to conspecifics’ nest and park sites, were related to maternal reproductive success; mothers whose litters were parked in closer proximity to others’ nests experienced higher infant survival than those whose nests were more isolated. This is likely because nesting proximity facilitated communal crèche use by neighboring females. Together, these results suggest a complex pattern of nesting behaviors that involves females strategically building nests in areas with high potential resource abundance, using nests in areas according to their realized productivity, and communally rearing infants within a network of nests distributed throughout the larger communal territory.
I‐Zone and Best‐in‐Show Winners
Authors: Donelan Jenny 
Published: January 2019

The Society for Information Display honored six exhibiting companies at Display Week 2015 in San Jose last June. These companies were Ubiquitous Energy for best prototype in the Innovation Zone and AUO, BOE, Fogale Sensation, Nanosys, and Nippon Electric Glass for Best‐in‐Show winners on the main exhibit floor.
Reduction of Cortical Bone Turnover and Erosion Depth After 2 and 3 Years of Denosumab: Iliac Bone Histomorphometry in the FREEDOM Trial
Authors: Chavassieux Pascale , Portero-Muzy Nathalie , Roux Jean Paul , Horlait Stéphane , Dempster David W , Wang Andrea , Wagman Rachel B , Chapurlat Roland 
Published: January 2019

ABSTRACT

Denosumab, a RANKL inhibitor, reduced the risk of vertebral, hip, and nonvertebral fractures in the Fracture REduction Evaluation of Denosumab in Osteoporosis every 6 Months (FREEDOM) trial of postmenopausal women with osteoporosis compared with placebo. Previous bone histomorphometric analysis in FREEDOM showed decreased bone resorption and turnover in cancellous bone after 2 and 3 years. The purpose of the present study was to evaluate the effects of denosumab compared with placebo in the cortical compartment from transiliac bone biopsies obtained during FREEDOM. A total of 112 specimens were evaluable for cortical histomorphometry, including 67 obtained at month 24 (37 placebo, 30 denosumab) and 45 at month 36 (25 placebo, 20 denosumab). Eroded surface, osteoclast surface, erosion depth, and wall thickness were measured on the endocortical surface. Cortical thickness and cortical porosity were also measured. Dynamic parameters of bone formation were assessed for endocortical, periosteal, and intracortical envelopes. Endocortical osteoclast surface, eroded surface, and mean and maximum erosion depth were significantly lower in the denosumab group versus placebo at months 24 and 36 (p &lt; 0.0001 to p = 0.04). Endocortical wall thickness and intracortical measures (cortical porosity and cortical thickness) were not different between the two groups. Dynamic parameters were low with tetracycline labels in cortical bone observed in 13 (43%) and 10 (50%) of denosumab biopsies at months 24 and 36, respectively, reflecting a marked decrease in bone turnover. In conclusion, our data reveal the mechanism of action of denosumab on cortical bone: inhibition of osteoclastic resorption and reduced activation of new remodeling sites. In addition, reduced endocortical erosion depth with no change of wall thickness may contribute to increased bone strength by reducing the bone loss and fragility associated with deep resorption cavities and may likely contribute to the greater BMD gain with denosumab than with other antiresorptive agents. © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.
Neutrophils injure gallbladder interstitial Cajal‐like cells in a guinea pig model of acute cholecystitis
Authors: Lin Meng‐Juan , Chen Lei , Huang Zhen‐Peng , Qiu Hu , Yu Bao‐Ping 
Published: January 2019

AbstractAcute cholecystitis is a common disease with gallbladder dysmotility. Disease pathogenesis involves immune cell infiltration as well as changes in gallbladder interstitial Cajal‐like cells (ICLCs). However, it remains unclear if or how the immune cells affect ICLC morphology, density, distribution, and function in gallbladder tissue during acute cholecystitis. In this study, we explored the acute cholecystitis‐related alterations in gallbladder ICLCs in a guinea pig model, focusing on the effects of neighboring neutrophils. Adult guinea pigs were randomly divided into four groups (control, 24 hr common bile duct ligation [CBDL], 48‐hr CBDL, and antipolymorphonuclear neutrophil [PMN] treated) and analyzed using methylene blue staining and immunofluorescence. Gallbladder contractility was also monitored. To culture gallbladder ICLCs, collagenase digestion was performed on tissue from 10‐ to 15‐day‐old guinea pigs. Neutrophils isolated from the peripheral blood of experimental animals 48‐hr postsurgery were also cocultured with the gallbladder ICLCs. Intracellular calcium was detected with Fluo‐4 AM dye. Our results showed that gallbladder ICLC density significantly declined during acute cholecystitis and was accompanied by shortening of the cellular processes and damage to their network‐like structure. However, pretreatment with anti‐PMN partially prevented these changes. Gallbladder contraction was also significantly decreased during acute cholecystitis, and this appeared to be mediated by the neutrophils. Moreover, ICLCs cocultured with neutrophils also had shortened and reduced processes and impaired network‐like structure formation. Intracellular calcium transient was less sensitive to contraction agonists and inhibitors when cocultured with neutrophils. Taken together, neutrophils greatly affect gallbladder ICLCs and dysmotility during acute cholecystitis.
Crime location choices: A geographical analysis of German serial killers
Authors: Synnott John , Bakker Marije , Ioannou Maria , Canter David , van der Kemp Jasper 
Published: January 2019

AbstractThe present study examined whether there are different processes operating in the crime location choices between body‐disposing and non‐body‐disposing serial killers and between sexual serial killers and acquisitive serial killers. A sample of 49 series of solved German serial killings is used to examine the differences in travelled distances between these groups of killers. Nonparametric tests revealed that body‐disposing and non‐body‐disposing serial killers and sexual and acquisitive serial killers did not constitute subgroups of serial killers regarding their spatial behaviour. The results suggest that the compared groups are subjected to the same factors that influence their travelled distances. Furthermore, the possible role of planning and anticipated emotions in crime location choices of serial killers is discussed, as well as the limitations of the study and recommendations for future research.
Exploring and Promoting the College Attendance and Success of Racial/Ethnic Minority Students
Authors: Bauman Stephanie San Miguel , Acker‐Hocevar Michele , Talbot Danny L. , Visaya Amelia , Valencia Monica , Ambriz Jennifer 
Published: January 2019

Using consensual qualitative research methodology and being mindful of both challenges and successes, the authors explored diverse students’ experiences with higher education. The authors used semistructured interviews with 7 students with racial/ethnic minority backgrounds to investigate the circumstances under which these students decided to attend college and experienced success. Multiple factors that were reported to contribute to students’ college attendance and success emerged, including individual factors, psychological factors, social factors, and cultural/environmental factors.Utilizando una metodología de investigación cualitativa consensuada y teniendo en cuenta tanto los desafíos como los éxitos, los autores exploraron las experiencias de estudiantes diversos en la educación superior. Los autores usaron entrevistas semiestructuradas con 7 estudiantes de minorías raciales/étnicas para investigar las circunstancias en las que estos estudiantes decidieron cursar estudios universitarios y tuvieron éxito. Surgieron múltiples factores reportados que contribuyeron a la asistencia y al éxito de los estudiantes en la universidad, incluyendo factores individuales, factores psicológicos, factores sociales y factores culturales/del entorno.