bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of “Single” vs. “Multiple” possession and usage of loyalty programme on re-purchase intention behavior of airline frequent passengers in India
Authors: Pappachan Joemon 
Published: October 2018

Purpose: This paper tries to find out the effect of single vs. multiple possession and usage of frequent flyer programme by frequent passengers on their re-purchase intention behavior in India. Design/methodology/approach: This paper tested the hypotheses, whether the variations in possession level of frequent flyer programme influences the relationship among the selected antecedent variables such as passengers’ satisfaction with the loyalty programme, passengers’ level of trust in the airline and the perceived brand image on the re-purchase intention behavior of frequent passengers. A structural equation model depicting the re-purchase behavior of frequent flyers were developed and tested. Findings: There exists an overall statistical validity of the model build-up by using structural equation modeling. Significant differences are observed in brand and trust variables in influencing re-purchase intention behavior of frequent passengers. This finding was further verified in correspondence to the variations in loyalty programme status and possession levels of loyalty programme memberships.Practical implications: Re-purchase behavior of passengers holding single and multiple loyalty programme memberships were compared and drawn implications for the airlines to guesstimate re-purchase intentions of regular passengers. Originality/value: The empirical findings of this study proves that there is a tendency to shift from single to multiple possessions of airline loyalty memberships while the frequent passengers progress on their travel needs. This study proclaimed that passengers possessing single loyalty programme are more influenced by brand image of the airline where as passengers using multiple loyalty programmes are by and large accustomed by means of the trust in the airline services than its brand image.
Comparison of hybrid 18F.fluorodeoxyglucose positron emission tomography/magnetic resonance imaging and positron emission tomography/computed tomography for evaluation of peripheral nerve sheath tumors in patients with neurofibromatosis type 1
Authors: Raad Roy A. , Lala Shailee , Allen Jeffrey C. , Babb James , Mitchell Carole Wind , Franceschi Ana M. , Yohay Kaleb , Friedman Kent P. 
Published: October 2018

AbstractRapidly enlarging, painful plexiform neurofibromas (PN) in neurofibromatosis type 1 (NF1) patients are at higher risk for harboring a malignant peripheral nerve sheath tumor (MPNST). Fludeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been used to support more invasive diagnostic and therapeutic interventions. However, PET/CT imparts an untoward radiation hazard to this population with tumor suppressor gene impairment. The use of FDG PET coupled with magnetic resonance imaging (MRI) rather than CT is a safer alternative but its relative diagnostic sensitivity requires verification. Ten patients (6 females, 4 males, mean age 27 years, range 8–54) with NF1 and progressive PN were accrued from our institutional NF Clinic. Indications for PET scanning included increasing pain and/or progressive disability associated with an enlarging PN on serial MRIs. Following a clinically indicated whole?body FDG PET/CT, a contemporaneous PET/MRI was obtained using residual FDG activity with an average time interval of 3-4 h FDG?avid lesions were assessed for both maximum standardized uptake value (SUVmax) from PET/CT and SUVmax from PET/MR and correlation was made between the two parameters. 26 FDG avid lesions were detected on both PET/CT and PET/MR with an accuracy of 100%. SUVmax values ranged from 1.4–10.8 for PET/CT and from 0.2?5.9 for PET/MRI. SUVmax values from both modalities demonstrated positive correlation (r = 0.45, P < 0.001). PET/MRI radiation dose was significantly lower (53.35% ± 14.37% [P = 0.006]). In conclusion, PET/MRI is a feasible alternative to PET/CT in patients with NF1 when screening for the potential occurrence of MPNST. Reduction in radiation exposure approaches 50% compared to PET/CT.
Up-regulation of autophagy and apoptosis of cochlear hair cells in mouse models for deafness
Authors: Xu Fei-long , Cheng Yanjie , Yan Wenya 
Published: October 2018

IntroductionHearing loss is one of the most common sensory disorders. Recent findings have shown that the apoptotic program and autophagy are related to hearing loss. The aim of the study was to explore the effects of noise and cisplatin exposure on apoptosis and autophagy in the hair cells of the cochleae.Material and methodsC57BL/6 mice were randomly divided into 3 groups (n = 10 for each): the control group, the noise model group and the cisplatin model group. Auditory brainstem response (ABR) measurements were used to detect the hearing thresholds. TUNEL assay was used to evaluate cell apoptosis. Western blot and immunofluorescence were performed to examine the apoptosis- and autophagy-related proteins.ResultsThe mice exhibited substantial hearing loss after noise and cisplatin exposure. Additionally, more TUNEL positive cells were observed in the mice after noise and cisplatin exposure compared with the control group. Moreover, the protein expression levels of Beclin-1, LC3-II, Bax and cleaved caspase-3 were significantly increased, while the expression of Bcl-2 was notably decreased in the cochlea after noise (p = 0.0278, 0.0075, 0.0142, 0.0158, 0.0131 respectively) and cisplatin (p = 0.0220, 0.0075, 0.0024, 0.0161, 0.0452 respectively) exposure compared with the control group. Besides, the ratio of LC3-II/LC3-I was substantially higher in the mice treated by cisplatin (p = 0.0046) and noise (p = 0.0220) compared with the control group.ConclusionsOur findings demonstrated for the first time that noise and cisplatin exposure promoted apoptosis and autophagy in the hair cells of the cochleae. This study provides new insights into the mechanisms of noise- or cisplatin-induced hearing loss.
Clinical manifestations of device-related infective endocarditis in cardiac resynchronization therapy recipients
Authors: Jędrzejczyk-Patej Ewa , Mazurek Michał , Kowalski Oskar , Sokal Adam , Liberska Agnieszka , Szulik Mariola , Podolecki Tomasz , Kalarus Zbigniew , Lenarczyk Radosław 
Published: October 2018

IntroductionThe aim of the study was to analyse microbiological charac�teristics and clinical manifestations of cardiac device-related infective endo�carditis (CDRIE) in cardiac resynchronization therapy (CRT) recipients, and
to compare the diagnostic value of modified Duke (MDC) versus modified
Duke lead criteria (MDLC; including to MDC local infection and pulmonary
infection or embolism as major criteria).Material and methodsThe study population comprised 765 consecutive
CRT patients from a high-volume, tertiary care centre from 2002 to 2015. All
patients were screened for CDRIE.ResultsDuring a median follow-up of 1692 days (range: 457–3067) 5.36%
of patients (n = 41) developed CDRIE, which was accompanied by CRT pocket
infection in 17.1% (n = 7) and recurrent pulmonary infection or pulmonary
embolism in 29.3% (n = 12). Fever was present in 95.1% of patients (n = 39),
whereas blood cultures were positive in 65.9% (n = 27). Staphylococcus was
the most prevalent pathogen in 59.3% (n = 16), Gram-negative bacteria in
25.9% (n = 7). Transoesophageal echocardiography showed intracardiac veg�etations in 73.2% of patients (n = 30). Non-different pathogen types with the
most common methicillin-sensitive Staphylococcus aureus were observed for
early versus late CDRIE (endocarditis ≤ 6 vs. > 6 months from CRT or other de�vice-related procedure). All 3 inflammatory markers (C-reactive protein, white
blood cells, procalcitonin) were normal in 4.9% of patients (n = 2). MDC versus
MDLC indicated definite CDRIE in 48.8% versus 80.5%, respectively (p = 0.003).ConclusionsFever is the most common symptom of CRT-related CDRIE, and
transoesophageal echocardiography allows vegetations to be visualised in
nearly 3/4 of patients with CDRIE. Although the most common pathogens
were Staphylococci, Gram-negative bacteria accounted for a quarter of
CDRIE. Modified Duke lead criteria proved superior to MDC.
O desenvolvimento sustentável no combate à pobreza e à exclusão social
Authors: Pinheiro Maria Lenir Rodrigues , Vieira Ricardo Stanziola 
Published: October 2018

Resumo: O presente artigo tem o objetivo analisar a pobreza e a exclusão na conjuntura moderna, tendo como base o direito ao desenvolvimento econômico sustentável. O desenvolvimento deste artigo é realizado em quatro seções. Na primeira, aborda-se a ideia de desenvolvimento sustentável, seguida pela análise do desenvolvimento econômico sustentável na segunda seção. Na terceira seção, trata-se da relação entre cidadania e o direito ao desenvolvimento. Na última seção, aborda-se o direito ao desenvolvimento econômico sustentável no esforço de combate à pobreza e à exclusão social. A dificuldade de encontrar formas de inserção social conduz à necessidade urgente de reconstrução do Estado na busca do combate à pobreza e à exclusão social, à efetivação da cidadania, partindo do direito a ter direitos, assim como a concretude do direito humano ao desenvolvimento. Verifica-se que a assistência ao desenvolvimento dos países pobres emerge urge a realização de ações coordenadas dos países ricos, bem como dos próprios pobres, refletindo na efetivação e concretização dos direitos ao desenvolvimento e do desenvolvimento, por meio de um pacto global pelo direito ao desenvolvimento.Palavras-chave: Cidadania. Desenvolvimento econômico. Desenvolvimento sustentável. Direito ao desenvolvimento. Exclusão. Pobreza.
O direito ao trabalho da pessoa com deficiência: perspectivas de liberdade e de igualdade
Authors: Villatore Marco Antônio César , Cochran Augustus Bonner , Campagnoli Adriana De Fátima Pilatti Ferreira 
Published: October 2018

Resumo: Os indivíduos deficientes representam cerca de dez por cento da população mundial, sendo fundamental sua inserção na sociedade. Diante desse cenário, o objetivo deste trabalho é apresentar uma nova perspectiva para o trabalho de pessoas com deficiência, considerando as regras internacionais e a evolução desse direito no Brasil, com especial atenção à Lei nº. 13.146, de 6 de julho de 2015, denominada Estatuto da Pessoa com Deficiência. Trata-se da possibilidade de uma pessoa com deficiência ter a caracterização de liberdade e de igualdade com os demais trabalhadores, demonstrando que para cada deficiência existe um sentido diverso de eficiência. A revisão dessas categorias opera-se mediante a atualização de seus referenciais, tendo em vista os recentes desenvolvimentos das ciências humanas e os acontecimentos históricos que ensejaram uma profunda revisão das posturas críticas.Palavras-chave: Diferença. Direito ao trabalho. Liberdade. Igualdade. Pessoa com deficiência.
Covalent Phenanthroline Framework Derived FeS@Fe3C Composite Nanoparticles Embedding in N‐S‐Codoped Carbons as Highly Efficient Trifunctional Electrocatalysts
Authors: Kong Fantao , Fan Xiaohong , Kong Aiguo , Zhou Ziqian , Zhang Xiaoying , Shan Yongkui 
Published: October 2018

AbstractEfficient and earth‐abundant materials with multifunctional electrocatalytic properties within a wide range of pH are the new darlings for developing green energy conversion and storage techniques. A novel porous covalent phenanthroline framework (Fe‐Phen‐COFs) that involved Fe‐DMSO (dimethyl sulfoxide) coordination complexes is successfully synthesized using 3, 8‐dibromophenanthroline and 1, 3, 5‐benzenetriboronicacid trivalent alcohol ester as a rigid building block via Suzuki coupling reaction. Fe‐Phen‐COFs as the self‐carrier enriched with Fe, S, N, and C is pyrolyzed to produce N‐S‐codoping carbons with embedded core–shell Fe3C and FeS composite nanostructures (FeS/Fe3C@N‐S‐C). The FeS/Fe3C@N‐S‐C‐800 obtained by pyrolysis at 800 °C exhibits efficient trifunctional electrocatalytic activity for oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER) within a wide pH range. Impressively, the ORR half‐potential of FeS/Fe3C@N‐S‐C‐800 reaches 0.87 V in 0.1 m KOH, more positive than the previously reported Pt‐free electrocatalysts. It could be utilized as the advanced air electrode materials in zinc–air batteries, which exhibit an excellent power density and cycling stability superior to those of Pt/C‐based zinc–air battery. Thermal conversion of novel Fe‐Phen‐COFs provides an effective strategy to prepare high‐performance trifunctional electrocatalytic materials for the new‐generation powerful energy conversion technologies.
Encapsulation of Ni3Fe Nanoparticles in N‐Doped Carbon Nanotube–Grafted Carbon Nanofibers as High‐Efficiency Hydrogen Evolution Electrocatalysts
Authors: Li Tongfei , Luo Gan , Liu Kunhao , Li Xin , Sun Dongmei , Xu Lin , Li Yafei , Tang Yawen 
Published: October 2018

AbstractThe exploration of cost‐effective yet high‐efficiency inexpensive electrocatalysts for the hydrogen evolution reaction (HER) is of critical significance for future renewable energy conversion technologies. A feasible electrospinning strategy to construct a novel 1D hierarchical nanoarchitecture comprising Ni3Fe nanoalloy‐encapsulated carbon nanotubes grown onto N‐doped carbon nanofibers (abbreviated as Ni3Fe@N‐C NT/NFs) is demonstrated here. Benefiting from the abundant firmly immobilized Ni3Fe nanoparticles for catalytic sites and hierarchical fibrous nanostructures for effective electron transport and mass diffusion, the resultant Ni3Fe@N‐C NT/NFs display an extraordinary HER activity with a low overpotential of 72 mV to reach a current density of 10 mA cm−2 in KOH medium and a remarkable stability for 40 000 s. Theoretical studies corroborate that the resultant Ni3Fe@N‐C NT/NFs exhibit a favorable Gibbs free energy of hydrogen adsorption (ΔGH* = −0.14 eV), further manifesting their superior HER activity. The present work will advance the development of highly efficient nonprecious electrocatalysts for energy conversion.
3D‐Printed Graphene Oxide Framework with Thermal Shock Synthesized Nanoparticles for Li‐CO2 Batteries
Authors: Qiao Yun , Liu Yang , Chen Chaoji , Xie Hua , Yao Yonggang , He Shuaiming , Ping Weiwei , Liu Boyang , Hu Liangbing 
Published: October 2018

AbstractLi‐CO2 batteries have emerged as a promising energy storage technology due to their high theoretical energy density. A thick electrode design is an effective approach for further increasing the energy density on device level by decreasing the weight and volume ratios of inactive materials. Exploring and designing novel thick electrodes with high catalytic activity toward reversible reaction between lithium and carbon dioxide are key challenges to achieve a low charge overpotential, long cycling stability, and high rate performance. Herein, an ultrathick electrode (≈0.4 mm) design for Li‐CO2 batteries by anchoring ultrafine Ni nanoparticles (≈5 nm) on a 3D‐printed reduced graphene oxide framework via thermal shock (1900 K for 54 ms) is demonstrated. The cathode displays low overpotential of 1.05 V at 100 mA g−1, high cycling stability of over 100 cycles, and good rate capability (up to 1000 mA g−1). In particular, a high areal capacity of 14.6 mA h cm−2 can be achieved due to the thick electrode design and uniform distribution of ultrafine catalyst nanoparticles. The strategy of combining an advanced 3D printing technique with fast thermal shock represents a promising direction toward thick electrode design in energy storage devices that are not limited to Li‐CO2 batteries.
Promoting Role of MXene Nanosheets in Biomedical Sciences: Therapeutic and Biosensing Innovations
Authors: Soleymaniha Mohammadreza , Shahbazi Mohammad‐Ali , Rafieerad Ali Reza , Maleki Aziz , Amiri Ahmad 
Published: October 2018

AbstractMXene nanosheets have emerged as biocompatible transition metal structures, which illustrate desirable performance for various applications due to their unique structural, physicochemical, and compositional features. MXenes are currently expanding their usage territory from mechanical, optical, chemical, and electronic fields toward biomedical areas. This is mainly originated from their large surface area and strong absorbance in near‐infrared region, which in combination with their facile surface functionalization with various polymers or nanoparticles, make them promising nanoplatforms for drug delivery, cancer therapy, precise biosensing and bioimaging. The facile surface modification of the MXenes can mediate the better in vivo performance of them through reduced toxicity, enhanced colloidal stability, and extended circulation within the body. Herein, the synthesis and state‐of‐the‐art progresses of MXene nanosheets designed for biomedical applications, including structural‐ and dose‐dependent antimicrobial activity, photothermal therapy, drug delivery, and implants are emphasized. Furthermore, biosensing applications are highlighted and a comprehensive discussion on photoacoustic imaging, magnetic resonance imaging, computed tomography imaging, and optical imaging of MXenes is presented. The challenges and future opportunities of applying MXene nanomaterials in the area of biomedicine are also discussed.
Topotactic Transformations in an Icosahedral Nanocrystal to Form Efficient Water‐Splitting Catalysts
Authors: Oh Aram , Kim Ho Young , Baik Hionsuck , Kim Byeongyoon , Chaudhari Nitin Kaduba , Joo Sang Hoon , Lee Kwangyeol 
Published: October 2018

AbstractDesigning high‐performance, precious‐metal‐based, and economic electrocatalysts remains an important challenge in proton exchange membrane (PEM) electrolyzers. Here, a highly active and durable bifunctional electrocatalyst for PEM electrolyzers based on a rattle‐like catalyst comprising a Ni/Ru‐doped Pt core and a Pt/Ni‐doped RuO2 frame shell, which is topotactically transformed from an icosahedral Pt/Ni/Ru nanocrystal, is reported. The RuO2‐based frame shell with its highly reactive surfaces leads to a very high activity for the oxygen evolution reaction (OER) in acidic media, reaching a current density of 10 mA cm−2 at an overpotential of 239 mV, which surpasses those of previously reported catalysts. The Pt dopant in the RuO2 shell enables a sustained OER activity even after a 2000 cycles of an accelerated durability test. The Pt‐based core catalyzes the hydrogen evolution reaction with an excellent mass activity. A two‐electrode cell employing Pt/RuO2 as the electrode catalyst demonstrates very high activity and durability, outperforming the previously reported cell performances.
Optimizing Process Parameters in Commercial Micro‐Stereolithography for Forming Emulsions and Polymer Microparticles in Nonplanar Microfluidic Devices
Authors: Männel Max J. , Selzer Lukas , Bernhardt Ricardo , Thiele Julian 
Published: October 2018

AbstractThe fabrication of microfluidic devices with nonplanar microchannel design by micro‐stereolithography (µSL) for oil‐in‐water (O/W) and water‐in‐oil (W/O) single emulsion as well as oil‐in‐water‐in‐oil (O/W/O) and water‐in‐oil‐in‐water (W/O/W) double emulsion formation is presented. By investigating separation distance, printing direction and voxel compensation in X,Y‐plane as key printing parameters, microflow cells with channel cross‐sections varying from 500 to 75 µm are printed, which are thus truly similar to those yielded by conventional stamped microfluidics. Without the need of controlling microchannel wettability, these flow cells are employed for forming O/W and W/O microdroplets, ≈130–80 µm in diameter and narrow size distribution of 2%, and at frequencies of up to 2.9 kHz. The as‐formed emulsion droplets are then utilized as templates for preparing hydrophobic and hydrophilic polymer microparticles, respectively. Likewise, O/W/O and W/O/W double emulsions are prepared in a single microflow cell to extend the applicability of nonplanar, 3D‐printed microfluidic devices. For each set of experiments, the same single flow cell is used to prove the reusability and robustness of the 3D‐printed flow cells compared to microfluidic flow cells fabricated by conventional, combined photo‐ and soft‐lithography.
Multistage Delivery Nanoparticle Facilitates Efficient CRISPR/dCas9 Activation and Tumor Growth Suppression In Vivo
Authors: Liu Qi , Zhao Kai , Wang Chun , Zhang Zhanzhan , Zheng Chunxiong , Zhao Yu , Zheng Yadan , Liu Chaoyong , An Yingli , Shi Linqi , Kang Chunsheng , Liu Yang 
Published: October 2018

AbstractCRISPR/dCas9 systems can precisely control endogenous gene expression without interrupting host genomic sequence and have provided a novel and feasible strategy for the treatment of cancers at the transcriptional level. However, development of CRISPR/dCas9‐based anti‐cancer therapeutics remains challenging due to the conflicting requirements for the design of the delivery system: a cationic and membrane‐binding surface facilitates the tumor accumulation and cellular uptake of the CRISPR/dCas9 system, but hinders the circulating stability in vivo. Here, a multistage delivery nanoparticle (MDNP) that can achieve tumor‐targeted delivery of CRISPR/dCas9 systems and restore endogenous microRNA (miRNA) expression in vivo is described. MDNP is designed as a core‐shell structure in which the shell is made of a responsive polymer that endows MDNP with the capability to present different surface properties in response to its surrounding microenvironment, allowing the MNDP overcoming multiple physiological barriers and delivering the payload to tumor tissues with an optimal efficiency. Systemic administration of MDNP/dCas9‐miR‐524 to tumor‐bearing mice achieved effective upregulation of miR‐524 in tumors, leading to the simultaneous interferences of multiple signal pathways related to cancer cell proliferation and presenting remarkable tumor growth retardation, suggesting the feasibility of utilizing MDNP to achieve tumor‐targeting delivery of CRISPR/dCas9 with sufficient levels to realize its therapeutic effects.
2D Metal Organic Framework‐Graphitic Carbon Nanocomposites as Precursors for High‐Performance O2‐Evolution Electrocatalysts
Authors: Rodenas Tania , Beeg Sebastian , Spanos Ioannis , Neugebauer Sebastian , Girgsdies Frank , Algara‐Siller Gerardo , Schleker Peter Philipp Maria , Jakes Peter , Pfänder Norbert , Willinger Marc , Greiner Mark , Prieto Gonzalo , Schlögl Robert , Heumann Saskia 
Published: October 2018

AbstractThe development of effective and precious‐metal‐free electrocatalysts for the oxygen evolution reaction (OER) represents a major bottleneck to unlock a renewable energy scenario based on water splitting technologies. Materials uniting the electrical conductivity of conjugated graphitic nanomaterials with the chemical regularity of metal‐organic‐framework (MOF) crystals are promising precursors for such electrocatalysts. Nanoscale integration of these two materials is challenging. A new synthesis route is developed that integrates 2D MOF nanocrystals and graphitic carbon nanolamellae into layered composites. The graphitic carrier contributes excellent charge–transport properties, and the 2D macromolecular MOF precursor provides a suitable shuttle for introducing highly dispersed metal species. Furthermore their direct chemical environment can be controlled via selection of organic linker. Thermal decomposition of 2D cobalt tetrafluoro benzene‐dicarboxylate MOF nanocrystals within such composites enables the stabilization of cobalt oxyhydroxyfluoride nanoparticles on the graphitic carrier, which display an extraordinary activity for the OER in alkaline media, with low onset overpotential (310 mVRHE) and current densities >104 mA cm−2 μmolCo−1 at an operating overpotential of 450 mV, alongside excellent operational stability. The wide compositional array of MOFs makes this synthesis approach versatile toward advanced (electro)catalysts and other functional materials for applications from sensing to energy storage and conversion.