bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Divergent Roles of Dietary Saturated and Monounsaturated Fatty Acids on Nerve Function in Murine Models of Obesity
Authors: Rumora Amy E. , LoGrasso Giovanni , Hayes John M. , Mendelson Faye E. , Tabbey Maegan A. , Haidar Julia A. , Lentz Stephen I. , Feldman Eva L. 
Published: March 2019

Neuropathy is the most common complication of prediabetes and diabetes and presents as distal-to-proximal loss of peripheral nerve function in the lower extremities. Neuropathy progression and disease severity in prediabetes and diabetes correlates with dyslipidemia in man and murine models of disease. Dyslipidemia is characterized by elevated levels of circulating saturated fatty acids (SFAs) that associate with the progression of neuropathy. Increased intake of monounsaturated fatty acid (MUFA)-rich diets confers metabolic health benefits; however, the impact of fatty acid saturation in neuropathy is unknown. This study examines the differential effect of SFAs and MUFAs on the development of neuropathy and the molecular mechanisms underlying the progression of the complication. Male miceMus musculusfed a high-fat diet rich in SFAs developed robust peripheral neuropathy. This neuropathy was completely reversed by switching the mice from the SFA-rich high-fat diet to a MUFA-rich high-fat diet; nerve conduction velocities and intraepidermal nerve fiber density were restored. A MUFA oleate also prevented the impairment of mitochondrial transport and protected mitochondrial membrane potential in cultured sensory neurons treated with mixtures of oleate and the SFA palmitate. Moreover, oleate also preserved intracellular ATP levels, prevented apoptosis induced by palmitate treatment, and promoted lipid droplet formation in sensory neurons, suggesting that lipid droplets protect sensory neurons from lipotoxicity. Together, these results suggest that MUFAs reverse the progression of neuropathy by protecting mitochondrial function and transport through the formation of intracellular lipid droplets in sensory neurons.SIGNIFICANCE STATEMENTThere is a global epidemic of prediabetes and diabetes, disorders that represent a continuum of metabolic disturbances in lipid and glucose metabolism. In the United States, 80 million individuals have prediabetes and 30 million have diabetes. Neuropathy is the most common complication of both disorders, carries a high morbidity, and, despite its prevalence, has no treatments. We report that dietary intervention with monounsaturated fatty acids reverses the progression of neuropathy and restores nerve function in high-fat diet-fed murine models of peripheral neuropathy. Furthermore, the addition of the monounsaturated fatty acid oleate to sensory neurons cultured under diabetic conditions shows that oleate prevents impairment of mitochondrial transport and mitochondrial dysfunction through a mechanism involving formation of axonal lipid droplets.
Application of mobile health, telemedicine and artificial intelligence to echocardiography
Authors: Seetharam Karthik , Kagiyama Nobuyuki , Sengupta Partho P. 
Published: March 2019

Abstract
The intersection of global broadband technology and miniaturized high-capability computing devices has led to a revolution in the delivery of healthcare and the birth of telemedicine and mobile health (mHealth). Rapid advances in handheld imaging devices with other mHealth devices such as smartphone apps and wearable devices are making great strides in the field of cardiovascular imaging like never before. Although these technologies offer a bright promise in cardiovascular imaging, it is far from straightforward. The massive data influx from telemedicine and mHealth including cardiovascular imaging supersedes the existing capabilities of current healthcare system and statistical software. Artificial intelligence with machine learning is the one and only way to navigate through this complex maze of the data influx through various approaches. Deep learning techniques are further expanding their role by image recognition and automated measurements. Artificial intelligence provides limitless opportunity to rigorously analyze data. As we move forward, the futures of mHealth, telemedicine and artificial intelligence are increasingly becoming intertwined to give rise to precision medicine.
The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods
Authors: Greer Frank R. , Sicherer Scott H. , Burks A. Wesley ,   COMMITTEE ON NUTRITION,   SECTION ON ALLERGY AND IMMUNOLOGY, Abrams Steven A. , Fuchs George J. , Kim Jae H. , Lindsey C. Wesley , Magge Sheela N. , Rome Ellen S. , Schwarzenberg Sarah Jane , Matsui Elizabeth C. , Bird John Andrew , Davis Carla McGuire , Hernandez-Trujillo Vivian Pilar , Mahr Todd A. , Orange Jordan S. , Pistiner Michael , Wang Julie , Williams Paul V. 
Published: March 2019

This Clinical Report was retired.
This clinical report updates and replaces a 2008 clinical report from the American Academy of Pediatrics, which addressed the roles of maternal and early infant diet on the prevention of atopic disease, including atopic dermatitis, asthma, and food allergy. As with the previous report, the available data still limit the ability to draw firm conclusions about various aspects of atopy prevention through early dietary interventions. Current evidence does not support a role for maternal dietary restrictions during pregnancy or lactation. Although there is evidence that exclusive breastfeeding for 3 to 4 months decreases the incidence of eczema in the first 2 years of life, there are no short- or long-term advantages for exclusive breastfeeding beyond 3 to 4 months for prevention of atopic disease. The evidence now suggests that any duration of breastfeeding ≥3 to 4 months is protective against wheezing in the first 2 years of life, and some evidence suggests that longer duration of any breastfeeding protects against asthma even after 5 years of age. No conclusions can be made about the role of breastfeeding in either preventing or delaying the onset of specific food allergies. There is a lack of evidence that partially or extensively hydrolyzed formula prevents atopic disease. There is no evidence that delaying the introduction of allergenic foods, including peanuts, eggs, and fish, beyond 4 to 6 months prevents atopic disease. There is now evidence that early introduction of peanuts may prevent peanut allergy.
METODE TERJAMAHAN TATA BAHASA DALAM PEMBELAJARAN MEMBACA KARANGAN EKSPOSISI
Authors: MARDHOTILLAH NUR FITRI 
Published: March 2019

Penelitian ini didasari pembelajaran bahasa Sunda di SMPN 1 Susukan kabupaten Cirebon seperti pembelajaran bahasa asing karena bahasa sehari-hari yang digunakan adalah bahasa Cirebon. Siswa kurang mengenal kosakata dan memahami tata bahasa dari bahasa Sunda, dengan metode terjemahan tata bahasa diharapkan bisa membantu siswa dalam memperkaya kosakata dan memahami tata bahasa Sunda. Penelitian ini dilakukan untuk mengetahui seberapa besar pengaruh metode terjemahan tata bahasa terhadap kemampuan kosakata dalam membaca karangan eksposisi. Metode penelitian yang digunakan dalam penelitian ini adalah metode eksperimen dengan desain pretest and posttest control group desaign. Populasi penelitian ini yaitu siswa kelas IX dengan sampel siswa kelas eksperimen yaitu siswa kelas IX B dan sampel kelas kontrol siswa kelas IX G SMPN 1 Susukan Kabupaten Cirebon Taun Ajaran 2014/2015. Hasil penelitian menunjukkan bahwa metode terjemahan tata bahasa efektif dalam meningkatkan kemampuan kosakata dalam membaca karangan eksposisi siswa kelas IX SMPN 1 Susukan Kabupaten Cirebon taun ajaran 2014/2015. Abstract The Backgound of this study is the condition of Sundanese language teaching in SMPN 1 Susukan, Cirebon Regency, that is similar to foreign language teaching. It is because the daily language used is the Cirebon language. Students are less familiar with the vocabulary and the grammar of Sundanese. The grammar translation method is expected to help students in enriching vocabulary and grammar to understand the Sundanese. This study was conducted to determine the influence of the grammar translation method to the vocabulary skills in reading the exposition essays. The method used in this study is the experimental method with the design of pretest and posttest control group. The population is 9th grade students with the sample consisting of the students of class IX B. The sample control consisted of students of class IX G. The results show that the grammar translation method is effective in improving student vocabulary skills in reading exposition texts.
PERBANDINGAN PERIBAHASA SUNDA DAN INDONESIA (Kajian Semantik Formal dan Etnopedagogik)
Authors: KULSUM UMI 
Published: March 2019

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan perbandingan peribahasa Sunda‐Indonesia secara semantik formal dan etnopedagogik dalam peribahasa yang memiliki makna sama. Penelitian ini menggunakan metode deskriptif. Pengumpulan data dilakukan dengan teknik studi pustaka dan analisis data dilakukan dengan analisis unsur langsung dan hermeneutik. Temuan penelitian ini menghasilkan empat deskripsi hasil penelitian, yaitu: (1) peribahasa Sunda memiliki pola-pola struktur kalimat, setiap pola memiliki sub-pola yang dibedakan berdasarkan kelas kata, jenis kata, kategori makna, dan sifat atau dari kata-kata yang membangun peribahasa sehingga ditemukan makna peribahasanya; (2) peribahasa Indonesia memiliki pola-pola struktur kalimat, setiap pola memiliki sub-pola yang dibedakan berdasarkan kelas kata, jenis kata, kategori makna, dan sifat-sifat dari kata-kata yang membangun peribahasa sehingga ditemukan makna peribahasanya; (3) 183 peribahasa Sunda dan Indonesia memiliki makna yang sama, dibangun oleh kata-kata yang sama dan kata-kata yang berbeda, dan dua diantaranya dibangun oleh kata-kata yang sama tapi memiliki makna yang berbeda; dan (4) peribahasa Sunda dan Indonesia yang memiliki makna yang sama memiliki nilai etnopedagogik berdasarkan moral kemanusiaan yang harus dimiliki oleh manusia yang masagi yang memiliki karakter trisilas dan pancarawayan. This study was aimed to identify and to describe the comparison of Sundanese and Indonesian proverbs that have same meaning in the perspective of formal semantics and etnopedagogy. This research used a descriptive method. The data was collected by library research techniques and the data analysis was done with the direct elemental analysis and hermeneutics. , The findings of this study resulted in four descriptions of research results. First, Sundanese proverbs have sentence structure patterns that differentiated by the class of words, the types of words, the category of meaning, and the nature or of words founding the meaning. Second, Indonesian proverbs have sentence structure patterns that differentiated by the class of words, the types of words, the category of meaning, and the nature or of words founding the meaning. Third, 183 Sundanese and Indonesian proverbs have the same meaning that are built by the same and the different words, while two of them built by the same words with different meanings. Fourth, the Sundanese and Indonesian proverb that have the same meaning contain ethnopedagogical values based on moral values of humanity that must be possessed by masagi (lit. complete) human beings who have the characters of trisilas and pancarawayan.
PIRANTI KOHESI SUBSTITUSI DALAM CERITA RADIN DJAMBAT (Kajian Intertekstual sebagai Pelansir Martabat dan Budaya Masyarakat Lampung)
Authors: Ariyani Farida , Suyanto Edi , Agustina Eka Sofia 
Published: March 2019

Indonesia kaya akan peninggalan cerita rakyat, termasuk cerita Radin Djambat yang ada di Lampung. Cerita Radin Djambat memuat nilai-nilai perjuangan, persahabatan, dan filosofi yang dapat dijadikan teladan bagi perkembangan dan pembangunan budaya bagi masyarakat Lampung secara khusus dan masyarakat Indonesia secara umum untuk kehidupan saat ini dan masa datang. Untuk itu, penelitian ini bertujuan untuk mendeskripsikan piranti kohesi substitusi dalam legenda Radin Djambat, sebagai pelansir martabat dan budaya masyarakat Lampung. Metode penelitian yang digunakan adalah studi dokumentasi melalui pendekatan intertekstual yang bersifat kualitatif. Hasil penelitian menunjukkan bahwa piranti kohesi substitusi yang terdapat dalam cerita Radin Djambat meliputi piranti yang bersifat anafora dan katafora. Piranti kohesi substitusi yang bersifat anafora ditemukan dalam bentuk substitusi nominal, verbal, dan klausal. Selanjutnya, piranti kohesi substitusi yang bersifat katafora yang ditemukan hanya dalam bentuk substitusi nominal dan klausal. Selanjutnya, hasil penelitian dapat dijadikan rujukan bagi masyarakat akademisi (peneliti), guru/dosen, mahasiswa, tokoh adat, dan masyarakat luas.ABSTRACTIndonesia is rich in relics of folklore, including the story of Radin Djambat in Lampung. Radin Djambat's story contains the values of struggle, friendship, and philosophy that can be exemplary for the development and cultural development for the people of Lampung in particular and the people of Indonesia in general This study aims to describe the substitution cohesion device in the legend of Radin Djambat, as the spreader of the dignity and culture of the people of Lampung. The research method used is documentation study through qualitative intertextual approach. The results showed that the substitution cohesion devices contained in the Radin Djambat story include anaphoric and cataphoric devices. Anaphoric substitution cohesion devices are found in the form of nominal, verbal, and clausal substitutions. Furthermore, the cataphoric substitution cohesion device is found only in the form of nominal substitution and clause. The results of the research can be used as a reference for other researchers, teachers, lecturers, students, traditional leaders, and the others community.
Gettier Problemi Bağlamında Epistemik Gerekçelendirme Anlayışının Kritiği
Authors: DURHAN Gülümser 
Published: March 2019

Kesin bilginin imkânı sorunu, geleneksel epistemolojide bilgi konusundaki tartışmaların zeminini oluşturmaktadır. Kimi, kesin bilginin imkânını savunurken; kimi, kesin bilgiye ulaşmanın imkânsız olduğu düşüncesiyle epistemolojide şüpheci tartışmalara vesile olmuşlardır. Ancak çağdaş epistemolojide bu anlayış yerini, gerekçelendirme sorununa bırakmıştır ve bilginin koşulu, inanç, doğruluk ve gerekçelendirmeye bağlı kılınmıştır. Gettier bu koşullardan, kesin bilginin elde edilemeyeceğini savunur ve gerekçelendirilmiş doğru inanç bilgi midir sorunsalı üzerinden düşüncelerine açıklık kazandırır. Ona göre, gerekçelendirme, bilgi için yetersizdir ve gerekçelendirilmiş olduğu düşünülen hallerde bile yanılabilirlik ihtimali ve rastlantısal durumlar olabilir. O halde çağdaş epistemolojinin merkezi problemi, doğru inancın bilgiye nasıl dönüşeceği, ne ölçüde gerekçelendirilebileceği ve gerekçelendirme yöntemlerinin bilgi de yanılma ihtimalini bütün olası durumlar için ortadan kaldırıp kaldıramayacağı düşüncesidir. Bu doğrultuda amacımız, Gettier düşüncesinde epistemik gerekçelendirmenin gerek ve yeterliliğinin mantıksal analizini yapmak ve bütün olası durumlar için bilgide yanılabilirliğin bütünüyle ortadan kaldırılmasının olanaklılığını tartışmaktır.
Multidirectionally Unstable Supracondylar Humeral Fractures in Children
Authors: Sharma Anmol , Sethi Anisha 
Published: March 2019

» Type-IV supracondylar humeral fracture is a rare pattern that presents with severe instability in both flexion and extension.» These fractures cause considerable difficulty in the achievement and maintenance of reduction by means of pinning with use of closed methods and may result in malalignment and a poor outcome.» Various authors have recommended their own modifications of Kirschner-wiring techniques for the treatment of these fractures.» Four studies focusing on the treatment of this fracture, including a total of 56 type-IV supracondylar humeral fractures and 406 type-III fractures (controls), were identified.» Because of its highly unstable nature, this type of fracture poses great difficulty in achieving and maintaining reduction with use of Kirschner wires and therefore requires special techniques.» Regardless of the technique used, the outcome of type-IV fractures appears to be similar to that of type-III fractures once a stable reduction is achieved.
Alternative Payment Models in Total Joint Arthroplasty Under the Affordable Care Act
Authors: Cizmic Zlatan , Novikov David , Feng James , Iorio Richard , Meftah Morteza 
Published: March 2019

» Since the passage of the U.S. Patient Protection and Affordable Care Act (ACA), health care has transitioned from a volume-based enterprise to a quality-based enterprise. Under this legislation, Alternative Payment Models (Bundled Payments for Care Improvement [BPCI], Comprehensive Care for Joint Replacement [CJR], and Accountable Care Organizations [ACOs]) have been developed to provide stakeholders with reimbursement systems that reward high-quality care and cost reduction.» The goal of this article was to elaborate on the various Alternative Payment Models and recent amendments and how these unique payment paradigms may offer orthopaedic surgeons innovative principles to further advance the quality and efficiency of total joint arthroplasty.
Spectrophotometric Determination of Chlorpromazine Hydrochloride Using 4-Nitroanilline by Oxidative Coupling Reaction
Authors: Et al. Al-rashidy 
Published: March 2019

A simple, rapid spectrophotometric method has been established for the determination of chlorpromazine hydrochloride (CPZ) in its pure form and in a tablet formulations. The suggested method is based on the oxidative coupling reaction with4-nitroainlline using KIO3 in acidic solution to produce a violet colored product with maximum absorption at λ=526 nm.The analytical data obtained throughout this study could be summarid as follows: 1ml of 1M HCl (pH=2.2), 1 ml of 4-nitroanilline (1x10-2M), and 1.5ml of (1x10-2)KIO3 per 25 ml reaction medium. The order of additions, coupling reaction time, and temperature in addition to the type of solvent were studied.
The Beer′s law is obeyed over the concentration range of(5–40) µg ml-1, but the detection limit and quantification limit are 0.34 besides 1.03 µg ml-1 respectively. The correlation coefficient (r) for the calibration graph was found to be 0.9980, molar absorptivity of 10. 25 × 103 L.mol -1.cm-1, and Sandell′s sensitivity index of 0.03467 µg.cm-2. The precision and accuracy of the method were tested by calculating the percentage of relative standard deviation (RSD%) (<1.831%) and the average recovery percent (99.22%) average error percent Erel%(0.558).
Direct and standard addition procedures were applied to both standards and specimens of pharmaceutical and the results indicate that the suggested method was successfully applied for the determination of CPZ.
Managing Wax-Deposition Risks in Oil Subsea Pipelines by Integrating Wax Modeling and Pigging Performance
Authors: Aslanov H.. , Novruzov A.. , Harun A.. 
Published: March 2019

Summary
Routine pigging is one of the strategies used to manage wax-deposition risks in an oil pipeline. When routine pigging cannot be performed, the excessive amount of wax must be gradually removed by progressive pigging—launching a series of pigs with increasing diameters. We successfully optimized the progressive-pigging process in a subsea oil pipeline network by integrating wax-deposition modeling and pigging performance data into a pig-size calculation tool. The tool assists in selecting the diameter size of the first pig to launch while minimizing the duration of the remediation pigging program and preventing the production deferral.
Enhanced Oil Recovery Test Based on Wells and Stations Utilization to Reduce Cost After Polymer Flooding
Authors: Gao Shuling , Peng Shukai , Han Peihui , Chen Guo , Liu Haibo , Yan Wei , Gao Ershuang 
Published: March 2019

Abstract
How to improve oil recovery for ultra-high water cut reservoir efficiently is a major technical problem needed to resolve in oilfield development at home and abroad. Currently, the water cut of reservoir and average oil recovery recovery factor have been as high as 95% and 56% after polymer flooding in Daqing Oilfeild, respectively, with 44% of the remaining geological reserves underground showing a great potential for further tapping. During the development of ultra-high water cut oilfield, we should consider reducing the investment cost of the new well drilling and stations so as to decrease cost and increase benefit. Specifically, we re-utilize the spare wells and injection distribution system of the injection stations after ASP flooding tests and significantly reduce investment cost. In this paper, we propose a new scheme of combining spare well station reusing and ASP flooding to further enhance oil recovery for the reservoir after polymer flooding. The field test, with 35 injection wells and 44 production wells, has been conducted in B2X block in Daqing Oilfield to reduce the cost of new drilling wells and new injection stations construction by 31.835 million dollars. By implementing physical simulation experiment to optimize the injection parameters and system formula, we determined that ASP formula for this test is to use polymer with 25 million molecular weight, petroleum sulfonate surfactant and sodium carbonate. The numerical simulation forecast shows that ASP flooding could further improve oil recovery by more than 10 percent. This test has been carried out and good response has been seen. The polymer pre-slug and the ASP main slug were injected in February and May 2015 respectively. Up to October 2017, the accumulated injection pore volume has been 0.61 PV, the injection pressure has risen by 4.2 MPa, the fluid absorption thickness ratio has increased by 31.4%, largest water cut decline of single well has reached 20.8% and the stage incremental oil recovery was 8.13%. Due to the reduced cost of no new drilling wells and no new injection station construction, the field test has achieved good technical and economic development effect. Now, the test area has increased oil by 1.161million barrels (158.9 thousand tons), with 58.07 million dollars economic returns. The prediction via numerical simulation shows that the final incremental oil recovery would be increased by 10.44%, the accumulated increasing oil production would be 1.491 million barrels (204 thousand tons), and the economic returns would be 74.57 million dollars (calculated as $50 per barrel). Through combing largely reducing the investment cost by reusing well station with ASP flooding, this field test achieved good technical and economic development effect. It can be broadly applied in ultra-high water cut blocks after polymer flooding in Daqing Oilfield.