bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer Health Impact Program (CHIP): Identifying Social and Demographic Associations of mHealth Access and Cancer Screening Behaviors Among Brooklyn, New York, Residents
Authors: Camacho-Rivera Marlene , Rice Samuel L. , Oh Sehyun , Paris Manuel , Akpara Ezinne , Molina Justen , Obadina Michael , Mcmillan Shireene , Aracena Joshua L. Mendez , Morency Jason , Muniz Rosario Costas , Gany Francesca , Brown Carol L. , Gonsky Jason , Osborne Joseph R. 
Published: February 2019

Abstract

Background:
The Bedford-Stuyvesant (BS) and Bushwick (BW) communities of central Brooklyn, New York, are located within the 50-mile core radius of Memorial Sloan Kettering's main catchment area. Cancer is the second leading cause of death among the predominantly African American and Hispanic neighborhoods, with BS and BW having higher prostate cancer and colorectal mortality rates than New York City as a whole. There is significant opportunity to design cancer interventions that leverage the accessibility and acceptability of mobile health (mHealth) tools among the BS and BW communities.

Methods:
The Cancer Health Impact Program (CHIP) is a collaborative that was formed for this purpose. Through CHIP, we used a tablet-based, Health Information National Trends (HINTS)-based multimodality survey to collect and analyze social and demographic patterns of prostate cancer and colorectal cancer screening, as well as mHealth access, among BS and BW residents.

Results:
Among 783 participants, 77% reported having a smartphone, 40% reported access to a mobile health application, 17% reported blood stool kit testing, and 26% of men reported PSA test screening. Multivariable logistic regression models results demonstrated that participants who reported owning smartphones, but were unsure whether they had access to a health app, were also significantly more likely to report blood stool kit testing compared with participants without smartphones. In fully adjusted models, access to a health app was not significantly associated with PSA testing. Non-Hispanic white participants were 86% less likely to report blood stool kit testing when compared with non-Hispanic black participants [OR = 0.15; 95% confidence interval (CI) 0.02–0.49]. Participants with a prior history of cancer were three times more likely to report blood stool kit testing when compared with those without cancer history (OR = 3.18; 95% CI, 1.55–6.63).

Conclusions:
For blood stool kit testing, significant differences were observed by race/ethnicity, cancer history, age, and smartphone use; for PSA screening, only age was significant in fully adjusted models.

Impact:
Our results demonstrate that while access to smartphones and mobile health apps may be prevalent among minority communities, other social and demographic characteristics are more likely to influence screening behaviors.
The Microbiome in Lung Cancer Tissue and Recurrence-Free Survival
Authors: Peters Brandilyn A. , Hayes Richard B. , Goparaju Chandra , Reid Christopher , Pass Harvey I. , Ahn Jiyoung 
Published: February 2019

Abstract

Background:
Human microbiota have many functions that could contribute to cancer initiation and/or progression at local sites, yet the relation of the lung microbiota to lung cancer prognosis has not been studied.

Methods:
In a pilot study, 16S rRNA gene sequencing was performed on paired lung tumor and remote normal samples from the same lobe/segment in 19 patients with non–small cell lung cancer (NSCLC). We explored associations of tumor or normal tissue microbiome diversity and composition with recurrence-free (RFS) and disease-free survival (DFS), and compared microbiome diversity and composition between paired tumor and normal samples.

Results:
Higher richness and diversity in normal tissue were associated with reduced RFS (richness P = 0.08, Shannon index P = 0.03) and DFS (richness P = 0.03, Shannon index P = 0.02), as was normal tissue overall microbiome composition (Bray–Curtis P = 0.09 for RFS and P = 0.02 for DFS). In normal tissue, greater abundance of family Koribacteraceae was associated with increased RFS and DFS, whereas greater abundance of families Bacteroidaceae, Lachnospiraceae, and Ruminococcaceae were associated with reduced RFS or DFS (P &lt; 0.05). Tumor tissue diversity and overall composition were not associated with RFS or DFS. Tumor tissue had lower richness and diversity (P ≤ 0.0001) than paired normal tissue, though overall microbiome composition did not differ between the paired samples.

Conclusions:
We demonstrate, for the first time, a potential relationship between the normal lung microbiota and lung cancer prognosis, which requires confirmation in a larger study.

Impact:
Definition of bacterial biomarkers of prognosis may lead to improved survival outcomes for patients with lung cancer.
C8orf76 Promotes Gastric Tumorigenicity and Metastasis by Directly Inducing lncRNA DUSP5P1 and Associates with Patient Outcomes
Authors: Wang Xiaohong , Liang Qiaoyi , Zhang Lianhai , Gou Hongyan , Li Ziyu , Chen Huarong , Dong Yujuan , Ji Jiafu , Yu Jun 
Published: February 2019

Abstract

Purpose:
We identified for the first time that C8orf76 (chromosome 8 open reading frame 76) is preferentially amplified in gastric cancer. We elucidated its role and clinical significance in gastric carcinogenesis.

Experimental Design:
The clinical impact of C8orf76 was assessed in 592 patients with gastric cancer. The biological function of C8orf76 was studied in vitro, in vivo, and in gastric cancer patient-derived organoid models. C8orf76 downstream effector and pathways were identified by RNA sequencing, chromatin immunoprecipitation sequencing, luciferase reporter, and electrophoretic mobility shift assay.

Results:
C8orf76 was upregulated in 69.74% and 65.71% of two independent cohorts of gastric cancers and was positively associated with C8orf76 amplification. Multivariate analysis showed that gastric cancer patients with C8orf76 amplification (cohort I, n = 129; cohort II, n = 107) or overexpression (n = 356) had a significantly shortened survival. C8orf76 significantly promoted gastric cancer cell proliferation, cell-cycle transformation, and migration/invasion, but suppressed cell apoptosis. Silencing C8orf76 expression exerted opposite effects in vitro and significantly inhibited xenograft tumor growth, lung metastasis, and liver metastasis in nude mice. Silencing C8orf76 also significantly suppressed the growth of patient-derived organoids. Mechanically, C8orf76 activated MAPK/ERK signaling cascade. C8orf76 directly bound to the promoter region of lncRNA dual specificity phosphatase 5 pseudogene 1 (DUSP5P1) with a binding motif of AGGCTG and activated DUSP5P1 transcription. DUSP5P1 induced MAPK/ERK signaling and promoted gastric tumorigenesis. Knockdown DUSP5P1 abrogated the effect of C8orf76 in activating MAPK/ERK cascade and the tumor-promoting function.

Conclusions:
C8orf76 directly binds to oncogenic lncRNA DUSP5P1 to induce its expression and activates MAPK signaling. C8orf76 plays a pivotal oncogenic role in gastric carcinogenesis and is an independent prognostic factor for gastric cancer patients.
A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer
Authors: Lok Sheau W. , Whittle James R. , Vaillant François , Teh Charis E. , Lo Louisa L. , Policheni Antonia N. , Bergin Alice R.T. , Desai Jayesh , Ftouni Sarah , Gandolfo Luke C. , Liew Danny , Liu He K. , Mann G. Bruce , Moodie Kate , Murugasu Anand , Pal Bhupinder , Roberts Andrew W. , Rosenthal Mark A. , Shackleton Kylie , Silva Maria João , Siow Zhen R. , Smyth Gordon K. , Taylor Leanne , Travers Avraham , Yeo Belinda , Yeung Miriam M. , Bujak Andjelija Zivanovic , Dawson Sarah-Jane , Gray Daniel H.D. , Visvader Jane E. , Lindeman Geoffrey J. 
Published: February 2019

Abstract

Venetoclax, a potent and selective BCL2 inhibitor, synergizes with endocrine therapy in preclinical models of ER-positive breast cancer. Using a phase Ib 3 + 3 dose-escalation and expansion study design, 33 patients with ER and BCL2-positive metastatic disease (mean prior regimens, 2; range, 0–8) were treated with daily tamoxifen (20 mg) and venetoclax (200–800 mg). Apart from uncomplicated “on-target” lymphopenia, no dose-limiting toxicities or high-grade adverse events were observed in the escalation phase (15 patients), and 800 mg was selected as the recommended phase II dose (RP2D). In the expansion phase (18 patients), few high-grade treatment-related adverse events were observed. For 24 patients treated at the RP2D, the confirmed radiologic response rate was 54% and the clinical benefit rate was 75%. Treatment responses were preempted by metabolic responses (FDG-PET) at 4 weeks and correlated with serial changes in circulating tumor DNA. Radiologic responses (40%) and clinical benefit (70%) were observed in 10 patients with plasma-detected ESR1 mutations.

Significance:
In the first clinical study to evaluate venetoclax in a solid tumor, we demonstrate that combining venetoclax with endocrine therapy has a tolerable safety profile and elicits notable activity in ER and BCL2-positive metastatic breast cancer. These findings support further investigation of combination therapy for patients with BCL2-positive tumors.
See related commentary by Drago et al., p. 323.
This article is highlighted in the In This Issue feature, p. 305
Association Between Fatty Acids of Blood Cell Membranes and Incidence of Coronary Heart Disease
Authors: Papandreou Christopher , Sala-Vila Aleix , Galié Serena , Muralidharan Jananee , Estruch Ramón , Fitó Montserrat , Razquin Cristina , Corella Dolores , Ros Emilio , Timiraos Juan , Lapetra Jose , Serra-Majem Lluis , Carlos Silvia , Castañer Olga , Asensio Eva M. , Salas-Salvadó Jordi , Bulló Mònica 
Published: February 2019

Objective—
To examine the associations between baseline levels of fatty acids in blood cell membranes and their 1-year changes with the incidence of coronary heart disease (CHD) in older adults at high cardiovascular disease risk.

Approach and Results—
This is a case-control study nested in the PREDIMED trial (Prevención con Dieta Mediterránea), with 136 CHD cases and 272 controls (matched on age, sex, body mass index, intervention group, and time of permanence in the study to the time event). We used gas chromatography to measure the proportion of 22 fatty acids in blood cell membranes at baseline and after 1 year. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% CIs. After adjustment for classical CHD risk factors and multiple testing, 1 SD increase in baseline levels of C22:0, C24:0 and the sum of individual very long chain saturated fatty acids was associated with 56% (OR, 0.44 [95% CI, 0.28–0.69]), 59% (OR, 0.41 [95% CI, 0.25–0.65]), and 55% (OR, 0.45 [95% CI, 0.29–0.70]) a decreased odds of developing CHD, respectively. Baseline C20:1n9 was associated with higher odds of CHD (OR, 1.58 [95% CI, 1.25–2.00]).

Conclusions—
Higher levels of C22:0 and C24:0 were associated with a lower CHD incidence, whereas higher levels of C20:1n9 were associated with a higher risk. This study adds to the growing body of evidence suggesting potential differences in the cardiovascular disease effects of different types of circulating saturated fatty acids.
Northern Hemisphere Extratropical Turbulent Heat Fluxes in ASRv2 and Global Reanalyses
Authors: Justino Flavio , Wilson Aaron B. , Bromwich David H. , Avila Alvaro , Bai Le-Sheng , Wang Sheng-Hung 
Published: February 2019

Abstract
Large-scale objectively analyzed gridded products and satellite estimates of sensible (H) and latent (LE) heat fluxes over the extratropical Northern Hemisphere are compared to those derived from the regional Arctic System Reanalysis version 2 (ASRv2) and a selection of current-generation global reanalyses. Differences in H and LE among the reanalyses are strongly linked to the wind speed magnitudes and vegetation cover. Specifically, ASRv2 wind speeds match closely with observations over the northern oceans, leading to an improved representation of H compared to the global reanalyses. Comparison of evaporative fraction shows that the global reanalyses are characterized by a similar H and LE partitioning from April through September, and therefore exhibit weak intraseasonal variability. However, the higher horizontal resolution and weekly modification of the vegetation cover based on satellite data in ASRv2 provides an improved snow–albedo feedback related to changes in the leaf area index. Hence, ASRv2 better captures the small-scale processes associated with day-to-day vegetation feedbacks with particular improvements to the H over land. All of the reanalyses provide realistic dominant hemispheric patterns of H and LE and the locations of maximum and minimum fluxes, but they differ greatly with respect to magnitude. This is especially true for LE over oceanic regions. Therefore, uncertainties in heat fluxes remain that may be alleviated in reanalyses through improved representation of physical processes and enhanced assimilation of observations.
Comparison of Satellite, Model, and In Situ Values of Photosynthetically Available Radiation (PAR)
Authors: Gould Richard W. , Ko Dong S. , Ladner Sherwin D. , Lawson T. Adam , MacDonald Clinton P. 
Published: February 2019

AbstractPhotosynthetically available radiation (PAR) incident at the sea surface penetrates into the water column and drives oceanic primary production. Ecosystem models to estimate phytoplankton biomass and primary production require an estimate of sea surface PAR, which is available from satellite ocean color imagery and atmospheric model predictions. Because the PAR values could come from either source, it is important to understand the variability and accuracies of each. We performed spatial and temporal analyses covering multiple years and seasons, and clear/cloudy conditions. We compare values derived from the imagery to those from the models and to in situ measurements in the Gulf of Mexico to validate the imagery and models and to assess PAR variability based on source. Averaged over space or time, the relative errors in PAR between the six sources (two satellite, three model, and in situ) are generally less than 5%–7%, but they can vary up to 11%. However, the errors and biases on a daily or pixel-by-pixel basis are larger, and the averages can mask seasonal trends.
An Assessment of Public Perceptions of Climate Change Risk in Three Western U.S. Cities
Authors: Sullivan Abigail , White Dave D. 
Published: February 2019

AbstractRisk perceptions influence individual and collective action related to climate change, and there is an important gap between public and expert perceptions of climate change risk, especially in the United States. Past studies have found that on average 40% of the American public believe climate change will affect them personally. We contribute a study of climate change risk perceptions in the metropolitan areas of three western U.S. cities (Denver, Colorado; Las Vegas, Nevada; Phoenix, Arizona), assessing overall patterns and drivers. A representative mail survey (N = 786) of the general public in these cities revealed that 60% of respondents identified climate change as personally risky, with the perception that it will impact either their family or their city in the next 30 years. Our results indicate that the gap in risk perceptions between the public and experts may be decreasing, although we discuss several limitations and reasons why this result requires further investigation. Using regression models, we analyze factors that are hypothesized to drive risk perceptions and discover that pro-environmental worldview and perceived personal responsibility are the most influential predictors. We discuss the implications of our results for fostering collective action to address climate change in dry, western U.S. metropolitan areas.
An Old Diaspora: Histories of Militancy by Palestinians with a Northeastern Accent
Authors: de Oliveira Luciana Garcia 
Published: February 2019

Most of the Palestinians who arrived in the cities of Northeastern Brazil came during the time of the Ottoman Empire in the nineteenth century, especially after the travels of Emperor Dom Pedro II. The arrival of Palestinians before the founding of the State of Israel in 1948 made many Palestinians and their descendants indifferent to the Israeli-Palestinian conflict. The situation changed in the 1980s as a result of the worsening situation of Palestinians in Lebanon, when the Palestine-Brazil Cultural Center was established in the city of Olinda, Pernambuco, and the deputy Raymundo Asfora made many speeches in defense of the Palestinian cause. These militant actions served as an inspiration for new generations of Palestinians born in Brazil. A maioria dos palestinos que chegaram à algumas cidades do nordeste brasileiro vieram durante a vigência do Império Turco Otomano, em pleno século XIX, sobretudo após as viagens do imperador do Brasil, Dom Pedro II ao Oriente Médio. A chegada dos palestinos antes da fundação do Estado de Israel (1948) foi determinante para que muitos palestinos e descentes fossem indiferentes ao conflito Israel-Palestina. A situação mudou, mais tarde, na década de 1980, durante o agravamento da situação dos palestinos no Líbano. Foi inaugurado o Centro Cultural Palestina-Brasil na cidade de Olinda, PE, e o deputado Raymundo Asfora realizava muitos discursos públicos em defesa da causa palestina. Essas ações militantes serviram de inspiração para as novas gerações de palestinos nascidos no Brasil.
Clinical and Procedural Evaluation of a Pharmacy Pharmacokinetic Consult Service
Authors: Chanas Tyler , Hockman Rebecca , Rice Terran , Cox-Hall Heather , Mallow-Corbett Stephanie , Alexander Bryan T. 
Published: February 2019

Purpose: Though previous studies have shown benefit with pharmacist-managed dosing of antibiotics, many institutions still do not offer such services. Our objective was to determine and report novel outcomes associated with the implementation of a pharmacist-managed pharmacokinetic/pharmacodynamic consult service and to assess the impact of direct pharmacist involvement in therapeutic drug monitoring. Methods: Retrospective cohort study of patients who received vancomycin or an aminoglycoside in the medical intensive care unit from January 5, 2013, to January 6, 2015, divided into 2 groups: before/after implementation of the consult service on January 6, 2014. Results: Nine-hundred sixty-two patients were included. Groups were similar at baseline. There were fewer critical values after implementation of the consult service (40.8% vs 27.3%, P < .001). The intervention group had significantly more vancomycin troughs within therapeutic range (15.4% vs 32.8%, P = .019). Time from order entry to medication administration was shorter when pharmacists entered the medication order, although this difference was nonsignificant (103 minutes vs 77 minutes, P = .054). Conclusion: Implementation of a pharmacist-managed dosing and monitoring program led to significantly decreased rates of critical value drug concentrations and increased rates of therapeutic concentrations, with a 25% (NS) decreased time-to-antibiotic administration, therefore demonstrating the additive value of the pharmacist-managed over pharmacist-monitored approach.
Primary Care Provider Continuity Is Associated With Improved Preventive Service Ordering During Brief Visits for Acute Symptoms
Authors: Matulis John C. , Schilling Jason J. , North Frederick 
Published: February 2019

Background: If a patient presents for an acute care visit and sees their assigned primary care provider (PCP), they may be more likely to receive preventive and other services than a patient not seeing their assigned PCP. Methods: After exclusion of 2 visits with insufficient information, we reviewed 98 consecutive, outpatient internal medicine 15-minute acute care visits comparing patients seeing their assigned PCP with those seeing a non-PCP provider. The primary outcome, preventive service ordering, was measured in 2 ways: percentage of patient visits with any preventive service ordered and the total number of preventive services ordered as a proportion of all preventive service items due for each entire cohort. The secondary outcome of other work completed was assessed by comparing tests and consults ordered, and by counting the number of physical examination elements and discrete medical diagnoses documented. Results: The PCPs were significantly more likely than non-PCPs to order any preventive service 45% versus 17% ( P = .005; odds ratio [OR]: 4.16, 95% confidence interval [CI]: 1.45-12.0). The PCP cohort ordered a higher proportion of the total number of preventive services due compared with the non-PCP cohort (30% vs 11%; P = .002; OR: 3.4, CI: 1.5-7.7). The PCPs also addressed more medical diagnoses (2.3 vs 1.4; P = .008) and more frequently ordered tests outside the reason for that visit (40% vs 13%; P = .003; OR: 4.27, CI: 1.5-11.8). Conclusion: Patients seeing their assigned PCP in brief, acute visits have higher rates of preventive and other service ordering compared to those not seeing their assigned PCP.
Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data
Authors: Jolliffe David A. , Ganmaa Davaasambuu , Wejse Christian , Raqib Rubhana , Haq M. Ahsanul , Salahuddin Nawal , Daley Peter K. , Ralph Anna P. , Ziegler Thomas R. , Martineau Adrian R. 
Published: February 2019

BackgroundRandomised controlled trials of adjunctive vitamin D in pulmonary tuberculosis (TB) treatment have yielded conflicting results. Individual participant data meta-analysis could identify factors explaining this variation.MethodsWe meta-analysed individual participant data from randomised controlled trials of vitamin D in patients receiving antimicrobial therapy for pulmonary TB. Primary outcome was time to sputum culture conversion. Secondary outcomes were time to sputum smear conversion, mean 8-week weight and incidence of adverse events. Pre-specified subgroup analyses were done according to baseline vitamin D status, age, sex, drug susceptibility, HIV status, extent of disease and vitamin D receptor genotype.ResultsIndividual participant data were obtained for 1850 participants in eight studies. Vitamin D did not influence time to sputum culture conversion overall (adjusted HR 1.06, 95% CI 0.91–1.23), but it did accelerate sputum culture conversion in participants with multidrug-resistant pulmonary TB (adjusted HR 13.44, 95% CI 2.96–60.90); no such effect was seen in those whose isolate was sensitive to rifampicin and/or isoniazid (adjusted HR 1.02, 95% CI 0.88–1.19; p-value for interaction=0.02). Vitamin D accelerated sputum smear conversion overall (adjusted HR 1.15, 95% CI 1.01–1.31), but did not influence other secondary outcomes.ConclusionsVitamin D did not influence time to sputum culture conversion overall, but it accelerated sputum culture conversion in patients with multidrug-resistant pulmonary TB.