bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unexpected planetary relationships as the new signature in Astro-particle physics
Authors: Zioutas K. , Anastassopoulos V. , Argiriou A. , Cantatore G. , Cetin S. , Gardikiotis A. , Haralambous H. , Karuza M. , Kryemadhi A. , Maroudas M. , Mastronikolis A. , Oikonomou C. , Ozbozduman K. , Semertzidis Y. K. , Tsagri M. , Tsagris I. 
Published: October 2024

Dunkle Materie (DM) came from unexpected cosmological observations. Nowadays within our solar system, diverse observations also defy conventional explanations, like the main physical process(es) underlying the heating of the different solar atmospheric layers. Streaming DM offers a viable common scenario following gravitational focusing by the solar system bodies. This fits as the underlying process behind the solar cycle, which was the first signature suggesting a planetary dependency. The challenge, since 1859, is to find a remote planetary impact, beyond the extremely feeble planetary tidal force. We stress the possible involvement of an external impact by some overlooked “streaming invisible matter”, which reconciles all investigated mysterious observations mimicking a not extant remote planetary force. Unexpected planetary relationships exist for both the dynamic Sun and Earth, reflecting multiple signatures for streaming DM. The local reasoning à la Zwicky is also suggestive for searches including puzzling biomedical phenomena. Favorite DM candidates are anti-quark-nuggets, magnetic monopoles, dark photons, or the composite “pearls”. Then, anomalies within the solar system are the manifestation of the dark Universe. The tentative streaming DM scenario enhances spatiotemporally the DM flux favouring conditions for direct DM detection or extracting energy from the not-so-invisible as anticipated dark sector.
Contemporary Surgical Approaches in Pediatric Aortic Valve Surgery: A Retrospective Comparison of Three Techniques
Authors: Komarov R. N. , Shumakov D. V. , Chernov I. I. , Belov V. A. , Chragyan V. A. , Ismailbaev A. M. , Tlisov B. M. , Enginoev S. T. , Kadyraliev B. K. , Didyk V. P. , Tarayan M. V. , Kurasov N. O. , Abzalova D. M. , Richmond Owusu 
Published: October 2024

Background: Congenital aortic valve (AV) disease is viewed in 2% of the population and in 20 out of 1000 neonates are presented with bicuspid configuration. Treatment of the congenital AV diseases requires multiple interventions. The ultimate goal is to provide adequate close to physiological left ventricle outflow and minimization of regurgitation. The optimal operative management of AV disease in children and young adults remains controversial. AV neocuspidization with glutaraldehyde‐treated autologous pericardium may be a satisfactory alternative in pediatric cardiac surgery.Objectives: The data of the AVNeo procedure results enable a comparative analysis of various AV reconstructive approaches in the pediatric cohort. In this article, we present the comparative study of various techniques in pediatric AV surgery, including the immediate and midterm outcomes of AVNeo, commissurotomy with aortic leaflet augmentation using pericardial patch (“free style” technique), and Ross procedure.Study Design: We conducted a retrospective analysis of the early and midterm results of surgical AV disease treatment of 44 children in 5 cardiac surgery centers from 2014 to 2022. The patients were divided into 3 groups: group I: glutaraldehyde‐treated autologous pericardium AVNeo (n = 12), group II: “free style” technique (n = 10), and group III: Ross procedure (n = 22). We described the immediate and midterm outcomes. The study design was approved by the ethics committees of the participating centers.Results: A total of 44 children after surgical treatment of the AV disease in 5 cardiac surgery centers were included in the study and were grouped as group I: AVNeo (n = 12), group II: “free style” technique (n = 10), and group III: Ross procedure (n = 22). The median follow‐up period was 57 ± 23.8 months. In‐hospital mortality was 4.5% (n = 2). In the midterm follow‐up, the peak pressure gradient was 18.45 ± 4.63 mmHg for group I and 8.9 ± 1.6 mmHg for group III (p = 0.00001), respectively. The cumulative freedom from reoperations was 100%, 30%, and 95.2% for 40 months of follow‐up and 100%, 30%, and 83.4% for 70 months of follow‐up in I, II, and III groups, respectively. No cases of midterm mortality were detected in all groups.Conclusion: The AV neocuspidization with glutaraldehyde‐treated autologous pericardium has an enormous advantage in pediatric AV surgery, significantly surpassing the freedom from resurgery of repair procedures and having comparable results with the Ross procedure in the midterm follow‐up.
Effects of 4 mg and 8 mg Dexamethasone Added to Intrathecal Bupivacaine on Perioperative Analgesia Among Adult Orthopedic Patients at Sodo Christian Hospital
Authors: Essayas Amanuel , Legesse Mebratu , Tila Mebratu , Sintayhu Ashagire , Abreham Eyosiyas , Dendir Getahun 
Published: October 2024

Background: Several adjuvant drugs have been tried to prolong spinal anesthesia block. Currently, dexamethasone appears to be effective in extending the duration of sensory block and enhancing analgesia during surgery. It is unclear, however, whether administering dexamethasone at a dose of 8 mg offers any advantages over administering it at a dose of 4 mg.Objective: To compare the effect of adding 4 and 8 mg dexamethasone to intrathecal bupivacaine on perioperative analgesia among adult orthopedic patients at Sodo Christian Hospital from June 1 to October 31, 2021.Methodology: A total of 178 adult patients undergoing elective orthopedic surgery were randomly assigned to one of the two groups through a prospective cohort research design. A systematic random sampling method was used. For analysis, data were imported into EpiData v.4.6 and exported to SPSS v.25. Levene’s test was used to verify homogeneity of variance, whereas the Shapiro–Wilk test was used to assess data distribution. The Mann–Whitney test and the independent sample t‐test were employed to compare numerical variables between study groups. Category variables were determined using the chi‐square test. p values were deemed statistically significant if they were less than 0.05.Result: Between groups, the perioperative and demographic features were similar. The mean durations of sensory block (347.42 ± 91.06 versus 341.46 ± 68.84), motor block (308.36 ± 80.91 versus 310.84 ± 75.50), and overall analgesia (421.51 ± 121.62 versus 412.40 ± 107.0) minutes did not show a statistically significant difference between the groups. In addition, there was no significant difference (p > 0.05) in postoperative analgesic use, initial analgesia rescue time, or pain severity, as measured by the Numerical Rating Scale (NRS). The addition of dexamethasone did not result in any issues, nor was there a statistically significant difference in the onset time between the two groups.Conclusion: Dexamethasone at a dose of 4 mg extends the duration of sensory, motor, and overall analgesia in a manner similar to that of 8 mg dexamethasone with comparable durations for both the initial analgesic request and overall analgesic use.
The Functional Transcriptomic Landscape Informs Therapeutic Strategies in Multiple Myeloma
Authors: Sudalagunta Praneeth Reddy , Canevarolo Rafael R. , Meads Mark B. , Silva Maria , Zhao Xiaohong , Cubitt Christopher L. , Sansil Samer S. , DeAvila Gabriel , Alugubelli Raghunandan Reddy , Bishop Ryan T. , Tungesvik Alexandre , Zhang Qi , Hampton Oliver , Teer Jamie K. , Welsh Eric A. , Yoder Sean J. , Shah Bijal D. , Hazlehurst Lori , Gatenby Robert A. , Van Domelen Dane R. , Chai Yi , Wang Feng , DeCastro Andrew , Bloomer Amanda M. , Siegel Erin M. , Lynch Conor C. , Sullivan Daniel M. , Alsina Melissa , Nishihori Taiga , Brayer Jason , Cleveland John L. , Dalton William , Walker Christopher J. , Landesman Yosef , Baz Rachid , Silva Ariosto S. , Shain Kenneth H. 
Published: October 2024

Abstract
Several therapeutic agents have been approved for treating multiple myeloma, a cancer of bone marrow–resident plasma cells. Predictive biomarkers for drug response could help guide clinical strategies to optimize outcomes. In this study, we present an integrated functional genomic analysis of tumor samples from patients multiple myeloma that were assessed for their ex vivo drug sensitivity to 37 drugs, clinical variables, cytogenetics, mutational profiles, and transcriptomes. This analysis revealed a multiple myeloma transcriptomic topology that generates “footprints” in association with ex vivo drug sensitivity that have both predictive and mechanistic applications. Validation of the transcriptomic footprints for the anti-CD38 mAb daratumumab (DARA) and the nuclear export inhibitor selinexor (SELI) demonstrated that these footprints can accurately classify clinical responses. The analysis further revealed that DARA and SELI have anticorrelated mechanisms of resistance, and treatment with a SELI-based regimen immediately after a DARA-containing regimen was associated with improved survival in three independent clinical trials, supporting an evolutionary-based strategy involving sequential therapy. These findings suggest that this unique repository and computational framework can be leveraged to inform underlying biology and to identify therapeutic strategies to improve treatment of multiple myeloma.
Significance: Functional genomic analysis of primary multiple myeloma samples elucidated predictive biomarkers for drugs and molecular pathways mediating therapeutic response, which revealed a rationale for sequential therapy to maximize patient outcomes.
FDA Approval Summary: Olutasidenib for Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia with an Isocitrate Dehydrogenase 1 Mutation
Authors: Woods Ashley C. , Norsworthy Kelly J. , Choe Moran , Gehrke Brenda J. , Chen Haiyan , Vallejo Jonathon , Pan Lili , Jiang Xiling , Li Hongshan , Kraft Jeffrey , Liu Jiang , Charlab Rosane , Okusanya Olanrewaju O. , Booth Brian , Pazdur Richard , Theoret Marc R. , Angelo de Claro R. 
Published: October 2024

Abstract
On December 1, 2022, the FDA approved the new molecular entity olutasidenib (Rezlidhia, Rigel Pharmaceuticals), a small-molecule inhibitor of isocitrate dehydrogenase 1, for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with a susceptible isocitrate dehydrogenase 1 mutation as detected by an FDA-approved test. The efficacy of olutasidenib was established based on complete remission (CR) + CR with partial hematologic recovery (CRh) rate, duration of CR + CRh, and conversion of transfusion dependence to transfusion independence in Study 2102-HEM-101. In the pivotal trial, 147 adult patients treated with 150 mg twice daily of olutasidenib were evaluable for efficacy. With a median follow-up of 10.2 months, the CR/CRh rate was 35% (95% confidence interval, 27%–43%), with a median duration of response of 25.9 months [95% confidence interval, 13.5–not reached]. Of the 86 patients who were transfusion dependent at baseline, 29 became transfusion independent (34%). The most common (≥20%) adverse reactions were nausea, fatigue, arthralgia, leukocytosis, dyspnea, pyrexia, rash, mucositis, diarrhea, and transaminitis. An assessment of long-term safety of olutasidenib is a condition of this approval.
Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma
Authors: Bischoff Megan E. , Shamsaei Behrouz , Yang Juechen , Secic Dina , Vemuri Bhargav , Reisz Julie A. , D’Alessandro Angelo , Bartolacci Caterina , Adamczak Rafal , Schmidt Lucas , Wang Jiang , Martines Amelia , Venkat Jahnavi , Tcheuyap Vanina Toffessi , Biesiada Jacek , Behrmann Catherine A. , Vest Katherine E. , Brugarolas James , Scaglioni Pier Paolo , Plas David R. , Patra Krushna C. , Gulati Shuchi , Landero Figueroa Julio A. , Meller Jarek , Cunningham John T. , Czyzyk-Krzeska Maria F. 
Published: October 2024

Abstract
Copper (Cu) is a cofactor of cytochrome c oxidase (CuCOX), indispensable for aerobic mitochondrial respiration. This study reveals that advanced clear cell renal cell carcinomas (ccRCC) accumulate Cu, allocating it to CuCOX. Using a range of orthogonal approaches, including metabolomics, lipidomics, isotope-labeled glucose and glutamine flux analysis, and transcriptomics across tumor samples, cell lines, xenografts, and patient-derived xenograft models, combined with genetic and pharmacologic interventions, we explored the role of Cu in ccRCC. Elevated Cu levels stimulate CuCOX biogenesis, providing bioenergetic and biosynthetic benefits that promote tumor growth. This effect is complemented by glucose-dependent glutathione production, which facilitates detoxification and mitigates Cu–H2O2 toxicity. Single-cell RNA sequencing and spatial transcriptomics reveal increased oxidative metabolism, altered glutathione and Cu metabolism, and diminished hypoxia-inducible transcription factor activity during ccRCC progression. Thus, Cu drives an integrated oncogenic remodeling of bioenergetics, biosynthesis, and redox homeostasis, fueling ccRCC growth, which can be targeted for new therapeutic approaches.

Significance:
The work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth.
Prospective Study of Sleep Talking and Risk of Stroke
Authors: Liu Ying , Chen Shuohua , Pavlova Milena , Li Yaqi , Liu Yesong , Zhang Jihui , Sun Liang , Yu Zhenjian , Gao Xiang 
Published: October 2024

Background
The potential clinical implication of sleep talking in relation to stroke has not been explored to date. This study aimed to prospectively examine the association between sleep talking and the risk of developing stroke in a community‐based cohort.

METHODS AND RESULTS
Included were 8001 participants (mean age, 54 years) of the Kailuan Study, China. Sleep talking was measured by a questionnaire in 2012. Cases of incident stroke were confirmed by review of medical records. Cox proportional hazards models were used to explore the association between sleep talking and stroke, adjusting for several sleep parameters (ie, insomnia, daytime sleepiness, sleep duration, snoring, and use of hypnotics) and other potential confounders. During 8 years of follow‐up, 333 incident stroke cases were identified. Relative to participants without sleep talking at baseline, those with sleep talking had a higher risk of developing stroke (hazard ratio [HR], 1.30 [95% CI, 1.03–1.65]), adjusting for potential confounders. Compared with participants without probable rapid eye movement sleep behavior disorder and sleep talking, those with sleep talking and probable rapid eye movement sleep behavior disorder had a higher risk of stroke (adjusted HR, 1.93 [95% CI, 1.40–2.66]).

Conclusions
The presence of sleep talking was associated with a higher risk of developing stroke. Future studies with cases of clinically confirmed sleep talking and a longer follow‐up would be appropriate to further investigate this association.
Perivascular Neutrophil Extracellular Traps Exacerbate Microvasospasm After Experimental Subarachnoid Hemorrhage
Authors: Nakagawa Ryota , Itokazu Takahide , Shibuya Nao , Kishima Haruhiko , Yamashita Toshihide 
Published: October 2024

BACKGROUND:
Subarachnoid hemorrhage (SAH) can lead to acute or delayed cerebral ischemia. Recent findings have revealed that spasm of microvessels, called microvasospasm, may contribute to SAH-related cerebral ischemia, and perivascular inflammation is considered important in the development of microvasospasms. However, owing to the difficulty in investigating the dynamics of vascular and perivascular events, little is known about the mechanisms underlying microvasospasms.

METHODS:
We established an experimental system aiming to investigate the vascular and perivascular pathology of SAH by combining a SAH mouse model with intravital 2-photon imaging. SAH was induced by intracisternal blood injection, and the distribution of erythrocytes, neutrophil behavior, and morphological changes in the pial arterioles were analyzed over time by 2-photon microscopy imaging. To further explore the role of neutrophils and neutrophil extracellular traps (NETs) in microvasospasm, we performed neutrophil depletion by intraperitoneal administration of neutrophil-specific antibody or NETs removal by intracisternal administration of DNase.

RESULTS:
Erythrocytes were immediately distributed in the perivascular space of the arterioles after SAH induction; neutrophils intensively infiltrated the perivascular space within 2 days and subsequently showed NETosis; and pial arterioles in the same region developed pearl-string-like microvasospasms in the subacute phase. Neutrophil depletion significantly reduced the number of microvasospasms. Furthermore, the removal of perivascular NETs drastically reduced microvasospasms.

CONCLUSIONS:
By establishing a unique experimental system, we demonstrated that perivascular NETs could be a new therapeutic target for microvasospasms.
Effects of Haptoglobin on Early Brain Injury, Vasospasm, and Lymphatic Drainage After Subarachnoid Hemorrhage in Mice
Authors: Kawakita Fumihiro , Nakajima Hideki , Suzuki Yume , Nampei Mai , Oinaka Hiroki , Suzuki Hidenori 
Published: October 2024

BACKGROUND:
Erythrolysis releases free Hb (hemoglobin), which is one of the most upstream and important molecules causing early brain injury and cerebral vasospasm after subarachnoid hemorrhage (SAH). The purpose of this study was to investigate if a Hb scavenger protein Hp (haptoglobin) supplementation prevents early brain injury and cerebral vasospasm and influences the lymphatic drainage mechanism in an established SAH model of mice by a blood injection into the prechiasmatic cistern.

METHODS:
This study consisted of 4 parts, with a total of 317 C57BL/6 male mice undergoing sham or SAH modeling, randomly followed by 24-hour intracerebroventricular infusion of no vehicle, 30.1 mg/mL BSA, 30.1 mg/mL Hp (100%; a mixture of Hp1-1, Hp2-1, and Hp2-2), 50% Hp, 25% Hp, and 12.5% Hp solutions from 30 minutes postmodeling. The effects were evaluated at 24 and 48 hours postmodeling.

RESULTS:
The 100%Hp decreased mortality and brain edema until 48 hours post-SAH and suppressed post-SAH neurological impairments, Hb infiltrations into the perivascular spaces and brain tissues, fibrinogen-positive microthrombi formation, microglial activation, and caspase-dependent neuronal apoptosis, as well as large-vessel vasospasm on India-ink angiography at 24 hours compared with vehicle-treated SAH mice. The Hp solutions up to 50% concentrations also prevented post-SAH neurological impairments, and those up to 25% concentrations suppressed post-SAH neuronal apoptosis and vasospasm development until 48 hours. Immunohistochemical staining of deep cervical and mandibular lymph nodes demonstrated that Hb was increased in the lymphatic sinus after SAH and was further increased by Hp administration in SAH animals.

CONCLUSIONS:
This study first showed that an Hp concentrate prevented early brain injury and cerebral vasospasm by inhibiting Hb penetration into brain tissues and increasing lymphatic drainage of free Hb in an established SAH model of mice.
VertexWiseR: A package for simplified vertex-wise analyses of whole-brain and hippocampal surfaces in R
Authors: Billaud Charly Hugo Alexandre , Yu Junhong 
Published: October 2024

Abstract
Currently, whole-brain vertex-wise analyses on brain surfaces commonly require specially configured operating systems/environments to run and are largely inaccessible to R users. As such, these analyses are inconvenient to execute and inaccessible to many aspiring researchers. To address these limitations, we present VertexWiseR, a user-friendly R package, to run cortical and hippocampal surface vertex-wise analyses, in just about any computer, requiring minimal technical expertise and computational resources. The package allows cohort-wise anatomical surface data to be highly compressed into a single, compact, easy-to-share file. Users can then run a range of vertex-wise statistical analyses with that single file without requiring a special operating system/environment and direct access to the preprocessed file directories. This enables the user to easily take the analyses “offline”, which would be highly appropriate and conducive in classroom settings. This R package includes a conventional suite of tools for extracting, manipulating, analyzing, and visualizing vertex-wise data, and is designed to be easy for beginners to use. Furthermore, it also contains novel or advanced functionalities such as hippocampal surface analyses, meta-analytic decoding, threshold-free cluster enhancement, and mixed-effects models that would appeal to experienced researchers as well. In the current report, we showcase these functionalities in the analyses of two publicly accessible datasets. Overall, our R package opens up new frontiers for the R’s user base/community and makes such neuroimaging analyses accessible to the masses.
FONDUE: Robust resolution-invariant denoising of MR images using Nested UNets
Authors: Adame-Gonzalez Walter , Brzezinski-Rittner Aliza , Zeighami Yashar , Chakravarty M. Mallar , Farivar Reza , Dadar Mahsa 
Published: October 2024

Abstract
Recent human magnetic resonance imaging (MRI) studies continually push the boundaries of spatial resolution as a means to enhance levels of neuroanatomical detail and increase the accuracy and sensitivity of derived brain morphometry measures. However, acquisitions required to achieve these resolutions have a higher noise floor, potentially impacting segmentation and morphometric analysis results. This study proposes a novel, fast, robust, and resolution-invariant deep learning method to denoise structural human brain MRIs. We explore denoising of T1-weighted (T1w) brain images from varying field strengths (1.5T to 7T), voxel sizes (1.2 mm to 250 µm), scanner vendors (Siemens, GE, and Phillips), and diseased and healthy participants from a wide age range (young adults to aging individuals). Our proposed Fast-Optimized Network for Denoising through residual Unified Ensembles (FONDUE) method demonstrated stable denoising capabilities across multiple resolutions with performance on par or superior to the state-of-the-art methods while being several orders of magnitude faster at low relative cost when using a dedicated Graphics Processing Unit (GPU). FONDUE achieved the best performance on at least one of the four denoising-performance metrics on all the test datasets used, showing its generalization capabilities and stability. Due to its high-quality performance, robustness, fast execution times, and relatively low-GPU memory requirements, as well as its open-source public availability, FONDUE can be widely used for structural MRI denoising, especially in large-cohort studies. We have made the FONDUE repository and all training and evaluation scripts as well as the trained weights available at https://github.com/waadgo/FONDUE.
The Political and Economic Effects of the Ukrainian War on the Arab Gulf Countries
Authors: Abou Zahr Maya 
Published: October 2024

Abstract
Russia’s “special military operation” against Ukraine began on February 24, 2022, sparking armed conflict between the two countries. This “operation” has had huge global effects, including on political architecture, the prices of goods and energy, food security, and immigration. The effects of the conflict have reached the Arab Gulf, and this article discusses the way in which the countries in the region have dealt with the conflict so far in political and economic terms. The article highlights Arab Gulf policies and the role of international energy markets and OPEC+. It also aims to clarify how the effects of the conflict will shape future relations between the Arab Gulf countries, on the one hand, and Russia, the West, and China, on the other.