bluuebunny/crossref_metadata_2025_split huggingface dataset:
Belastung des Neusiedler Sees mit anthropogenen Spurenstoffen: Überlegungen zu Herkunft und Verhalten
Authors: Zessner Matthias , Zoboli Ottavia , Reif Daniela , Amann Arabel , Sigmund Elisabeth , Kum Georg , Saracevic Zdravka , Saracevic Ernis , Kittlaus Steffen , Krampe Jörg , Wolfram Georg 
Published: September 2019

ZusammenfassungIm vorliegenden Artikel wird auf Basis unterschiedlicher Datenquellen in einem ersten Schritt die Belastung des Neusiedler Sees mit national oder gemeinschaftlich geregelten anthropogenen Spurenstoffen dargestellt. Darüber hinaus werden für ausgewählte Stoffe Eintragspfade in Wulka und Neusiedler See identifiziert und für weitere Stoffe wird ein mögliches Umweltverhalten im See dargestellt. Auch wenn derzeit ein umfassendes Monitoring von allen national oder gemeinschaftlich geregelten Spurenstoffen im Neusiedler See fehlt, kann für den überwiegenden Teil dieser Stoffe auf Basis von Untersuchungen in der Wulka bzw. Fischuntersuchungen im See eine Einhaltung der UQN angenommen werden. Für einzelne Stoffe ist eine Zielverfehlung geben oder anzunehmen. Für andere Stoffe ist zurzeit aufgrund analytischer Schwierigkeiten ein eindeutiger Befund nicht möglich. In Abhängigkeit vom Stoff und der Betrachtungsebene können sowohl Kläranlagenabläufe, landwirtschaftliche Erosion als auch die atmosphärische Deposition auf die Oberfläche des Sees die Einträge dominieren. Mit Bedachtnahme auf die große Zahl der in die aquatische Umwelt emittierten anthropogenen Spurenstoffe muss unabhängig von der Betrachtung von Einzelstoffen für den Neusiedler See eine ganz besondere Vulnerabilität für diese Form der Belastung diagnostiziert werden. Dies liegt vor allem an der Funktion des Sees als Stoffsenke. Persistente Spurenstoffe, die in den See gelangen, werden im Freiwasser aufkonzentriert oder in den Sedimentbereichen des Schilfs gespeichert, von wo sie allenfalls wieder mobilisiert werden können. Selbst wenn eine Vielzahl von schwer abbaubaren Spurenstoffen durch Ab- oder Umbau aus dem Freiwasser des Sees eliminiert wird, ist über die Endprodukte eines solchen Umbaus noch wenig bekannt bzw. sind diese aufgrund der Vielzahl möglicher Stoffe nicht gänzlich zu überwachen. Als Grundlage zur Entwicklung von Strategien für ein langfristiges und effizientes Management des Sees wäre ein regelmäßiges Monitoring von Spurenstoffen in See und Schilfgürtel deutlich zu verstärken, um Fehlentwicklungen im See frühzeitig erkennen zu können.
Do Locus of Control, Self-esteem, Hope and Shame Mediate the Relationship Between Financial Hardship and Mental Health?
Authors: Frankham Charlotte , Richardson Thomas , Maguire Nick 
Published: September 2019

Abstract
In a longitudinal study of 104 participants, the psychological factors of economic locus of control, self-esteem, hope and shame were explored for their impact on the relationship between financial hardship and mental health. Participants completed measures of financial hardship, the psychological factors and measures of mental health three times at three-monthly intervals. A hierarchical regression analyses indicated that subjective financial hardship, hope and shame significantly predicted mental health outcomes. Mediation analyses demonstrated that hope mediated the relationship between subjective financial hardship and depression, stress and wellbeing; that shame mediated the relationship between subjective financial hardship and anxiety; and that neither shame nor hope mediated the relationship between subjective financial hardship and suicide ideation.
Optical polarization shift in beams emitted by quantum cascade lasers
Authors: Pruszyńska-Karbownik Emilia , Gutowski Piotr , Karbownik Piotr 
Published: September 2019

Abstract
In this paper, we present experimental results of current-induced polarization change and transverse mode change in mid-infrared quantum cascade lasers. The polarization of laser beam was determined by measuring of far-field distributions of polarization projection on the linear polarization basis. The measured amount of TE-polarized light is associated with transversal mode structure, which was determined based on the far-field power distributions. The TE polarized light contribution in the beams varies from 6 to 19%. This quantity is anti-correlated to the fundamental transverse mode contribution.
Oxidation of cycloalkanes catalysed by N-hydroxyimides in supercritical carbon dioxide
Authors: Lisicki Dawid , Orlińska Beata 
Published: September 2019

Abstract
This paper reports cyclopentane, cyclohexane and cyclooctane oxidation in the presence of N-hydroxyphthalimide or 4-dodecyloxycarbonyl-N-hydroxyphthalimide in combination with Co(II) and Fe(II) salts using O2/CO2 mixture (0.5 MPa O2, 9.5 MPa CO2). The studies demonstrated that the application of scCO2 in cyclohexane and cyclooctane oxidation processes results in higher conversion and yield of respective ketone and alcohol in comparison to processes performed using air under pressure (0.7 MPa).
Addressing the Vepris verdoorniana complex (Rutaceae) in West Africa, with two new species
Authors: Cheek Martin , Onana Jean-Michel , Yasuda Shigeo , Lawrence Poppy , Ameka Gabriel , Buinovskaja Greta 
Published: September 2019

SummaryVepris verdoorniana(Rutaceae) has long been regarded as a widespread and variable species occurring from Guinea to Gabon. Recent evidence has shown that the original material from the type locality in Cameroon consists of two different species,V. verdoornianain the strict sense, endemic to Lower Guinea (Cameroon, Gabon and C.A.R. in W-C Africa) andV. letouzeyiOnana, which was thought to occur from Guinea to Cameroon. In this paper we show that the West African (Upper Guinea) material previously referred to asV. letouzeyi/V. verdoornianais separate morphologically from that in Cameroon (Lower Guinea). In fact the West African material referred to comprises two distinct species, here described asV. occidentalisCheek & Onana (Guinea to Ghana, but probably extending to Benin) a tree of lowland marginal dry evergreen and semi-deciduous forest, andV. ferCheek, a species restricted to four mainly lower submontane forest locations on iron substrates in Liberia and Sierra Leone (also Upper Guinea).Vepris occidentalisis here assessed as Least Concern due to its wide range and high frequency, whilstV. feris assessed as Endangered due to the low number of locations and threats from iron ore mining projects. Both new species are illustrated and mapped.
Cyber security and the brand
Authors: Chikada Akino 
Published: September 2019

A brand is an organisation's most valuable asset. It gives out strong messages, both explicit and implicit, to anyone who encounters it – customers, employees, advocates, investors and even competitors. It will leave a clear understanding of what the product or organisation is all about and if it is something which they may want to get more involved with. Many top brands such as Apple and Coca-Cola are valued in the tens of billions of pounds. 1, 2 Brand protection has become more of a priority in recent years and a key element of this for many organisations is keeping their customers safe. Incorporating cyber security best practices into brand-protection strategies as well as working with the right registrar are good places to start, explains Akino Chikada of MarkMonitor.
Two components is too simple: an example of oscillatory Fisher–KPP system with three components
Authors: Girardin Léo 
Published: September 2019

AbstractIn a recent paper by Cantrell et al. [9], two-component KPP systems with competition of Lotka–Volterra type were analyzed and their long-time behaviour largely settled. In particular, the authors established that any constant positive steady state, if unique, is necessarily globally attractive. In the present paper, we give an explicit and biologically very natural example of oscillatory three-component system. Using elementary techniques or pre-established theorems, we show that it has a unique constant positive steady state with two-dimensional unstable manifold, a stable limit cycle, a predator–prey structure near the steady state, periodic wave trains and point-to-periodic rapid travelling waves. Numerically, we also show the existence of pulsating fronts and propagating terraces.
Moving toward community based telehealth services using mhealth for hypertensive patients
Authors: Zare Sahar , Rezaee Rita , Aslani Azam , Shirdeli Mohammad , Kojuri Javad 
Published: September 2019

AbstractBackgroundAlthough self-care can control and prevent complications in hypertensive patients, self-care adherence is relatively low among these patients. Community-based telehealth services through mhealth can be an effective solution.ObjectiveThis study aimed to evaluate the effect and acceptance of an mhealth application as a community-based telehealth intervention on self-care behavior adherence.MethodThis clinical trial included sixty hypertensive patients and their matched controls from two heart clinics affiliated to Shiraz University of Medical Sciences (SUMS). Self-care behaviors were assessed using Hill-Bone questionnaire before and after the intervention. Acceptability was evaluated in the intervention group at the end of the study period. The data were analyzed via SPSS 18 software using descriptive and inferential statistics.ResultThe results showed a significant difference between the intervention and control groups regarding the mean score of self-care behaviors (4.13 ± 0.23 versus 3.18 ± 0.27, p < .001). Additionally, a significant difference was observed between the two groups concerning the mean scores of the two subscales of self-care behaviors, including “medication taking” and “proper diet”. However, no significant difference was observed between the two groups regarding the mean score of “appointment keeping” (p = .075). Overall, the intervention group participants were satisfied (4.27 ± 0.34) with this approach for managing hypertension.ConclusionCommunity-based telehealth services through mhealth had the potential to improve self-care behaviors in hypertensive patients and seemed to be accepted by the patients in the intervention group.
Epidemiology, molecular characterisation and antimicrobial susceptibility ofNeisseria gonorrhoeaeisolates in Madrid, Spain, in 2016
Authors: Guerrero-Torres M. D. , Menéndez M. B. , Guerras C. S. , Tello E. , Ballesteros J. , Clavo P. , Puerta T. , Vera M. , Ayerdi O. , Carrio J. C. , Mozo I. , Del Romero J. , Vázquez J. A. , Abad R. 
Published: September 2019

AbstractWith the aim to elucidate gonococcal antimicrobial resistance (AMR)–risk factors, we undertook a retrospective analysis of the molecular epidemiology and AMR of 104Neisseria gonorrhoeaeisolates from clinical samples (urethra, rectum, pharynx and cervix) of 94 individuals attending a sexually transmitted infection clinic in Madrid (Spain) from July to October 2016, and explored potential links with socio-demographic, behavioural and clinical factors of patients. Antimicrobial susceptibility was determined byE-tests, and isolates were characterised byN. gonorrhoeaemulti-antigen sequence typing. Penicillin resistance was recorded for 15.4% of isolates, and most were susceptible to tetracycline, cefixime and azithromycin; a high incidence of ciprofloxacin resistance (~40%) was found. Isolates were grouped into 51 different sequence types (STs) and 10 genogroups (G), with G2400, ST5441, ST2318, ST12547 and G2992 being the most prevalent. A significant association (P= 0.015) was evident between HIV-positive MSM individuals and having a ciprofloxacin-resistant strain. Likewise, a strong association (P= 0.047) was found between patient age of MSM and carriage of isolates expressing decreased susceptibility to azithromycin. A decrease in the incidence of AMR gonococcal strains and a change in the strain populations previously reported from other parts of Spain were observed. Of note, the prevalent multi-drug resistant genogroup G1407 was represented by only three strains in our study, while the pan-susceptible clones such as ST5441, and ST2318, associated with extragenital body sites were the most prevalent.
Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications
Authors: Ryu Yea Seong , Kang Kyoung Ah , Piao Mei Jing , Ahn Mee Jung , Yi Joo Mi , Bossis Guillaume , Hyun Young-Min , Park Chang Ook , Hyun Jin Won 
Published: September 2019

Abstract
Ambient air particulate matter (PM) induces senescence in human skin cells. However, the underlying mechanisms remain largely unknown. We investigated how epigenetic regulatory mechanisms participate in cellular senescence induced by PM with a diameter <2.5 (PM2.5) in human keratinocytes and mouse skin tissues. PM2.5-treated cells exhibited characteristics of cellular senescence. PM2.5 induced a decrease in DNA methyltransferase (DNMT) expression and an increase in DNA demethylase (ten–eleven translocation; TET) expression, leading to hypomethylation of the p16INK4A promoter region. In addition, PM2.5 led to a decrease in polycomb EZH2 histone methyltransferase expression, whereas the expression of the epigenetic transcriptional activator MLL1 increased. Furthermore, binding of DNMT1, DNMT3B, and EZH2 to the promoter region of p16INK4A decreased in PM2.5-treated keratinocytes, whereas TET1 and MLL1 binding increased, leading to decreased histone H3 lysine 27 trimethylation (H3K27Me3) and increased H3K4Me3 in the promoter of p16INK4A. PM2.5-induced senescence involved aryl hydrocarbon receptor (AhR)-induced reactive oxygen species (ROS) production. ROS scavenging dampened PM2.5-induced cellular senescence through regulation of DNA and histone methylation. Altogether, our work shows that skin senescence induced by environmental PM2.5 occurs through ROS-dependent the epigenetic modification of senescence-associated gene expression. Our findings provide information for the design of preventive and therapeutic strategies against skin senescence, particularly in light of the increasing problem of PM2.5 exposure due to air pollution.
Revisiting NTRKs as an emerging oncogene in hematological malignancies
Authors: Joshi Sunil K. , Davare Monika A. , Druker Brian J. , Tognon Cristina E. 
Published: September 2019

AbstractNTRK fusions are dominant oncogenic drivers found in rare solid tumors. These fusions have also been identified in more common cancers, such as lung and colorectal carcinomas, albeit at low frequencies. Patients harboring these fusions demonstrate significant clinical response to inhibitors such as entrectinib and larotrectinib. Although current trials have focused entirely on solid tumors, there is evidence supporting the use of these drugs for patients with leukemia. To assess the broader applicability for Trk inhibitors in hematological malignancies, this review describes the current state of knowledge about alterations in the NTRK family in these disorders. We present these findings in relation to the discovery and therapeutic targeting of BCR–ABL1 in chronic myeloid leukemia. The advent of deep sequencing technologies has shown that NTRK fusions and somatic mutations are present in a variety of hematologic malignancies. Efficacy of Trk inhibitors has been demonstrated in NTRK-fusion positive human leukemia cell lines and patient-derived xenograft studies, highlighting the potential clinical utility of these inhibitors for a subset of leukemia patients.
Effect of diabetes-specific nutrition formulas on satiety and hunger hormones in patients with type 2 diabetes
Authors: Mottalib Adham , Abrahamson Martin J. , Pober David M. , Polak Rani , Eldib Ahmed H. , Tomah Shaheen , Ashrafzadeh Sahar , Hamdy Osama 
Published: September 2019

Abstract
Objectives
Diabetes-specific nutritional formulas (DSNFs) are frequently used by patients with type 2 diabetes (T2D) as part of nutrition therapy to improve glycemic control and reduce body weight. However, their effects on hunger and satiety hormones when compared to an isocaloric standardized breakfast are not fully understood. This study aims to evaluate the postprandial effects of two DSNFs—Glucerna (GL) and Ultra Glucose Control (UGC)—versus oatmeal on selected satiety and hunger hormones.

Method
After an overnight fast, 22 patients with T2D (mean age 62.3 ± 6.8 years, A1C 6.8 ± 0.7%, body weight 97.4 ± 21.3 kg, and BMI 33.2 ± 5.9 kg/m²) were given 200 kcal of each meal on three separate days. Blood samples for amylin, cholecystokinin (CCK), ghrelin, glucagon, leptin, and peptide-YY (PYY) were collected at baseline and 30, 60, 90, 120, 180, and 240 min after the start of each meal. Incremental area under the curve (iAUC0-240) for each hormone was calculated.

Results
iAUC0-240 for glucagon and PYY were significantly higher after GL and UGC than after oatmeal (p < 0.001 for both). No difference was observed between the three meals on postprandial amylin, CCK, ghrelin, and leptin hormones.

Conclusions
Intake of DSNFs significantly increases secretion of PYY and glucagon, two important satiety hormones. While subjective satiety was not directly evaluated, the increased effect on satiety hormones may partially explain the mechanism of body weight loss associated with DSNF use.
Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome
Authors: Dashti S. Ghazaleh , Li Wing Yan , Buchanan Daniel D. , Clendenning Mark , Rosty Christophe , Winship Ingrid M. , Macrae Finlay A. , Giles Graham G. , Hardikar Sheetal , Hua Xinwei , Thibodeau Stephen N. , Figueiredo Jane C. , Casey Graham , Haile Robert W. , Gallinger Steven , Le Marchand Loïc , Newcomb Polly A. , Potter John D. , Lindor Noralane M. , Hopper John L. , Jenkins Mark A. , Win Aung Ko 
Published: September 2019

Abstract

Background
Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal cancer.

Methods
This study included 2023 (56.4% female) carriers with a mismatch repair gene mutation (737 in MLH1, 928 in MSH2, 230 in MSH6, 106 in PMS2, 22 in EPCAM) recruited by the Colon Cancer Family Registry between 1998 and 2012. Weighted Cox regression was used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the associations between self-reported type 2 diabetes, high cholesterol, triglyceride and colorectal cancer risk.

Results
Overall, 802 carriers were diagnosed with colorectal cancer at a median age of 42 years. A higher risk of colorectal cancer was observed in those with self-reported type-2 diabetes (HR 1.92; 95% CI, 1.03–3.58) and high cholesterol (HR 1.76; CI 1.23–2.52) compared with those without these conditions. There was no evidence of high triglyceride being associated with colorectal cancer risk.

Conclusion
For people with Lynch syndrome, self-reported type-2 diabetes mellitus and high cholesterol were associated with increased colorectal cancer risk.
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
Authors: Maugeri Marco , Nawaz Muhammad , Papadimitriou Alexandros , Angerfors Annelie , Camponeschi Alessandro , Na Manli , Hölttä Mikko , Skantze Pia , Johansson Svante , Sundqvist Martina , Lindquist Johnny , Kjellman Tomas , Mårtensson Inga-Lill , Jin Tao , Sunnerhagen Per , Östman Sofia , Lindfors Lennart , Valadi Hadi 
Published: September 2019

AbstractRNA-based therapeutics hold great promise for treating diseases and lipid nanoparticles (LNPs) represent the most advanced platform for RNA delivery. However, the fate of the LNP-mRNA after endosome-engulfing and escape from the autophagy-lysosomal pathway remains unclear. To investigate this, mRNA (encoding human erythropoietin) was delivered to cells using LNPs, which shows, for the first time, a link between LNP-mRNA endocytosis and its packaging into extracellular vesicles (endo-EVs: secreted after the endocytosis of LNP-mRNA). Endosomal escape of LNP-mRNA is dependent on the molar ratio between ionizable lipids and mRNA nucleotides. Our results show that fractions of ionizable lipids and mRNA (1:1 molar ratio of hEPO mRNA nucleotides:ionizable lipids) of endocytosed LNPs were detected in endo-EVs. Importantly, these EVs can protect the exogenous mRNA during in vivo delivery to produce human protein in mice, detected in plasma and organs. Compared to LNPs, endo-EVs cause lower expression of inflammatory cytokines.
The how’s and what’s of vaccine reactogenicity
Authors: Hervé Caroline , Laupèze Béatrice , Del Giudice Giuseppe , Didierlaurent Arnaud M. , Tavares Da Silva Fernanda 
Published: September 2019

AbstractReactogenicity represents the physical manifestation of the inflammatory response to vaccination, and can include injection-site pain, redness, swelling or induration at the injection site, as well as systemic symptoms, such as fever, myalgia, or headache. The experience of symptoms following vaccination can lead to needle fear, long-term negative attitudes and non-compliant behaviours, which undermine the public health impact of vaccination. This review presents current knowledge on the potential causes of reactogenicity, and how host characteristics, vaccine administration and composition factors can influence the development and perception of reactogenicity. The intent is to provide an overview of reactogenicity after vaccination to help the vaccine community, including healthcare professionals, in maintaining confidence in vaccines by promoting vaccination, setting expectations for vaccinees about what might occur after vaccination and reducing anxiety by managing the vaccination setting.
Label-free detection of transporter activity via GPCR signalling in living cells: A case for SLC29A1, the equilibrative nucleoside transporter 1
Authors: Vlachodimou Anna , IJzerman Adriaan P. , Heitman Laura H. 
Published: September 2019

AbstractTransporters are important therapeutic but yet understudied targets due to lack of available assays. Here we describe a novel label-free, whole-cell method for the functional assessment of Solute Carrier (SLC) inhibitors. As many SLC substrates are also ligands for G protein-coupled receptors (GPCRs), transporter inhibition may affect GPCR signalling due to a change in extracellular concentration of the substrate/ligand, which can be monitored by an impedance-based label-free assay. For this study, a prototypical SLC/GPCR pair was selected, i.e. the equilibrative nucleoside transporter-1 (SLC29A1/ENT1) and an adenosine receptor (AR), for which adenosine is the substrate/ligand. ENT1 inhibition with three reference compounds was monitored sensitively via AR activation on human osteosarcoma cells. Firstly, the inhibitor addition resulted in an increased apparent potency of adenosine. Secondly, all inhibitors concentration-dependently increased the extracellular adenosine concentration, resulting in an indirect quantitative assessment of their potencies. Additionally, AR activation was abolished by AR antagonists, confirming that the monitored impedance was AR-mediated. In summary, we developed a novel assay as an in vitro model system that reliably assessed the potency of SLC29A1 inhibitors via AR signalling. As such, the method may be applied broadly as it has the potential to study a multitude of SLCs via concomitant GPCR signalling.