bluuebunny/crossref_metadata_2025_split huggingface dataset:
How we perform ductulography in a tertiary referral centre for ductulography in Indonesia: case-series approach and a review
Authors: Supit Nina I. S. H. , Kusumaningtyas Nungky , Gultom Fajar Lamhot , Mudzakir Muhammad Adam , Sulay Callistus Bruce Henfry , Octavius Gilbert Sterling 
Published: December 2024

Abstract
Background
Ductulography is a key imaging technique for assessing nipple discharge. Despite modern advancements such as mammography and MRI, the relevance of ductulography in diagnosing pathologic nipple discharge (PND) remains significant, particularly in low-resource settings. This review examines our single-center experience with ductulography in Indonesia, highlighting patient characteristics and procedural outcomes.

Methods
This review is based on case-based experiences from a private tertiary hospital in Indonesia, a main referral center for ductulography. We describe 28 women who underwent ductulography between January 2019 and June 2024. This review is supplemented by the theories of ductulography and how we do it in our institution.

Results
The median age of the patients was 46.5 years (IQR: 42–53.5 years). Among the 28 women, 2 experienced non-spontaneous discharge, 12 had colorless discharge, 12 had bloody discharge, and the remaining had yellowish to brownish discharge. Laterality was almost evenly distributed with 14 right-sided, 13 left-sided, and 1 bilateral discharge. The Galactogram Imaging Classification System (GICS) outcomes were 2 patients with GICS 0, 7 with GICS 1, 17 with GICS 2, and 2 with GICS 4a. Histopathologic analyses were performed on three patients, revealing fibrocystic changes in two and intraductal papilloma with fibrocystic changes in one.

Conclusions
While ductulography may be considered an older technique, it remains a valuable diagnostic tool in the modern imaging era, especially in settings with limited access to advanced imaging modalities. Our single-center experience supports the continued use of ductulography, providing crucial preoperative mapping and aiding in the accurate diagnosis of PND.
Respiratory health problems among ferroalloys factory workers
Authors: Elghazally Shimaa A. , Zayet Hussein H. , Alkarn Ayah A. , Bazeed Alaa , ElKhayat Mariam Roshdy 
Published: December 2024

Abstract
Background
Ferrosilicon alloys are a mixture of iron and silicon. It offers better iron characteristics such as hardness, strength, and resistance to corrosion and heat by adding alloys of ferrosilicon to steel and cast iron. The ferrosilicon alloy industry workers are exposed to many hazards that can affect their respiratory function due to exposure to silica dust which is present in all steps in this industry mainly from furnaces, in addition to exposure to irritant gases in refining and casting operations. Thus, the current study was conducted to estimate the respiratory problems prevalence especially silicosis among workers of ferroalloy factories.

Results
All studied workers (100%) were males with a mean (± SD) age of 50.15 ± 5.77 years. Seventy percent of workers had been working for ≥ 20 years and 76.4% were working in places with high levels of exposure. About one-third of the studied workers were diagnosed with silicosis. There was a statistically significant higher occurrence of silicosis among workers aged ≥ 50 years old. Work duration and level of exposure were significant predictors of silicosis occurrence among studied workers.

Conclusion
Ferroalloy factory work environment affects the respiratory health of the workers and impairs their pulmonary function. It may increase the risk of developing silicosis which impacts the effectiveness of their work and quality of life. Workers in ferroalloys factories must receive regular medical care, and safety precautions are recommended.

Trial registration
ClinicalTrials.gov. NCT05374148. Registered May 13, 2022.
Phosphoenolpyruvate carboxylase (PEPC) is essential for the glycolytic pathway and parasite proliferation in Babesia gibsoni
Authors: Li Dong-Fang , Wang Ling-Na , Bai Yi-Dan , Yu Yu-Xin , Lu Xing , Guan Xing-Ai , Li Fang-Jie , Wang Sen , He Lan , Zhao Jun-Long 
Published: December 2024

AbstractApicomplexan parasites predominantly generate ATP and lactic acid through glycolysis and anaerobic glucose metabolism, incorporating CO2 into glycolysis via a stage-dependent phosphoenolpyruvate carboxylase (PEPC) mechanism. Although the role of PEPC in plant and bacterial carbon fixation is well documented, its function within Babesia remains largely unexplored. This study employs reverse genetics to probe the biological role of PEPC in Babesia gibsoni, noting its conservation across similar protozoa, suggesting a pivotal and conserved biological function. Western blotting and immunofluorescence (IFA) experiments using the BgPEPC-3 × Flag strain revealed that the BgPEPC protein has a molecular weight of 105 kDa and localizes predominantly to the cytoplasm. Attempts to knock out the PEPC gene in BgPEPC-3 × Flag strains failed under standard media conditions, succeeded only with the addition of 5 mM malate, an upstream metabolite of oxaloacetic acid (OAA). In addition to malate, the downstream metabolite of OAA can also partially compensate for the phenotypic defects caused by PEPC deficiency. This intervention alleviated severe growth deficits, underscoring the critical role of aspartate in the parasite lifecycle. Moreover, metabolic inhibitors such as L-cycloserine and triazamidine, which target aspartate aminotransferase and mitochondrial functions, respectively, demonstrated increased efficacy against BgPEPC knockout strains. The lack of a compensatory response to malic acid supplementation underscores the integral role of BgPEPC in intermediary carbon metabolism and its necessity in providing aspartate as a precursor to pyrimidine synthesis. Collectively, these findings suggest that PEPC could be a potential target for future drug development against B. gibsoni infections.
Graphical Abstract
Reverse time migration of mobile marine vibrator data
Authors: Almuteri Khalid , Sava Paul , Shragge Jeffrey 
Published: December 2024

Marine vibrators are viable alternatives to seismic air guns in ocean-bottom acquisition due to their less adverse impact on the environment, their ability to generate lower frequency content, and their suitability for simultaneous acquisition. However, mobile marine vibrators introduce a unique set of processing and imaging challenges for ocean-bottom acquisition, the main examples of which are the Doppler effect and the time-dependent source-receiver offsets, which are not features of conventional marine acquisitions. Standard seismic data processing and imaging techniques assume stationary sources and are not fully suitable for mobile marine vibrator data without modifications. Not accounting for source motion in seismic imaging introduces a phase change and a mispositioning of imaged structures. Further, ignoring source-motion effects in the imaging workflow may lead to the estimation of inaccurate migration velocity models or imply the use of incorrect migration velocity (e.g., in seismic-to-well ties). We develop a reverse time migration (RTM) approach that accounts for the source-motion effects and is capable of producing accurate subsurface images, closely matching stationary acquisition and imaging results. Synthetic examples show the ability of our method to construct accurate subsurface RTM images even for source velocities higher than those commonly used in typical marine acquisitions. Our approach is not limited to imaging mobile marine vibrator data in ocean-bottom acquisition but is also applicable to mobile streamer data using marine vibrators or seismic air-gun sources.
Association of General Anesthesia for Cesarean Delivery with Postpartum Depression and Suicidality
Authors: Guglielminotti Jean , Monk Catherine , Russell Matthew T. , Li Guohua 
Published: December 2024

BACKGROUND:
Compared to neuraxial anesthesia, general anesthesia (GA) for cesarean delivery is associated with an increased risk of postpartum depression (PPD) requiring hospitalization. However, obstetric complications occurring during childbirth (eg, stillbirth) are associated with both increased use of GA and increased risk of PPD, and may account for the reported association between GA and PPD. This study assessed the association of GA for cesarean delivery with PPD requiring hospitalization, outpatient visit, or emergency department (ED) visit, accounting for obstetric complications.

METHODS:
This retrospective cohort study included women who underwent a cesarean delivery in New York State between January 2009 and December 2017. Women were followed for 1 year after discharge for readmission, outpatient visit, or ED visit. The primary outcome was PPD requiring readmission, outpatient visit, or ED visit. The 2 secondary outcomes were (1) PPD requiring readmission, and (2) suicidality. Obstetric complications included severe maternal morbidity, blood transfusion, postpartum hemorrhage, preterm birth, and stillbirth. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of PPD, PPD requiring readmission, and suicidality associated with GA were estimated using the propensity score matching and the overlap propensity score weighting methods.

RESULTS:
Of the 325,840 women included, 19,513 received GA (6.0%; 95% CI, 5.9–6.1). Complications occurred in 43,432 women (13.3%) and the GA rate for these women was 9.7% (95% CI, 9.4–10.0). The incidence rate of PPD was 12.8 per 1000 person-years, with 24.5% requiring hospital readmission, and was higher when an obstetric complication occurred (17.1 per 1000 person-years). After matching, the incidence rate of PPD was 15.5 per 1000 person-years for women who received neuraxial anesthesia and 17.5 per 1000 person-years for women who received GA, yielding an aHR of 1.12 (95% CI, 0.97–1.30). Use of GA was associated with a 38% increased risk of PPD requiring hospitalization (aHR: 1.38; 95% CI, 1.07–1.77) and with a 45% increased risk of suicidality (aHR 1.45; 95% CI, 1.02–2.05). Results were consistent when using the overlap propensity score weighting.

CONCLUSIONS:
Use of GA for cesarean delivery is independently associated with a significantly increased risk of PPD requiring hospitalization and suicidality. It underscores the need to avoid using GA whenever appropriate and to address the potential mental health issues of patients after GA use, specifically by screening for PPD and providing referrals to accessible mental health providers as needed.
Innovative Application of Point of Care Ultrasound in Assessing Ventriculo-Peritoneal Shunt Patency
Authors: Thapa Amit , Adil Mohamed Zaidan 
Published: December 2024

BACKGROUND AND OBJECTIVES:
Current techniques to detect obstruction of ventriculo-peritoneal (VP) shunts are costly, invasive, and time-consuming. This study examines the efficacy of using point-of-care ultrasound (POCUS) to identify shunt nonpatency.

METHODS:
We conducted a single-center observational cohort study on patients with medium-pressure VP shunts for hydrocephalus. POCUS was used to evaluate shunt patency, and the results were compared with computed tomography/MRI/trans-fontanelle ultrasound evaluations for hydrocephalus.

RESULTS:
Among the 39 patients studied, 17.9% had shunt obstructions. Patients with obstructed shunts, on comparison with patent shunts, had higher optic nerve sheath diameter (ONSD): 4.3 ± 0.2 mm vs 4.1 ± 0.2 mm (P = .014), with an area under the curve (AUC) of 0.750 (95% CI 0.531-0.969), lower cerebrospinal fluid (CSF) flow velocity: distal to the chamber: 3.1 ± 2.9 cm/s vs 9.8 ± 3.1 cm/s (P = .000), with an AUC of 0.915 (95% CI 0.825-1.000) and proximal to the chamber: 3.3 ± 3.1 cm/s vs 8.9 ± 2.7 cm/s (P = .000), with an AUC of 0.906 (95% CI 0.810-1.000), and absence of free fluid in the peritoneal space (P = .000). Using the cutoff values obtained from the AUC analysis, raised ONSD ≥4.25 mm, CSF flow distal to the chamber ≤6.15 cm/s, CSF flow proximal ≤6.85 cm/s, and absence of free fluid in the peritoneal cavity predicted shunt nonpatency with 100% sensitivity and 100% negative predictive value (NPV, odds ratio 1.583 [95% CI 1.123-2.232, P = .003]). Even when excluding raised ONSD, the sensitivity and NPV remained 100% (odds ratio 1.875 [95% CI 1.168-3.010, P = .000]).

CONCLUSION:
Our study supports the novel use of POCUS for detecting sonological signs of VP shunt nonfunction with very high sensitivity and NPV. This technique is quick, safe, and cost-effective, making it an excellent option for outpatient surveillance of VP shunt obstruction.
Evaluation of the Accuracy of 4 Conventional Freehand Frontal Ventriculostomy Methods in the Chinese Population
Authors: Chen Xiaohai , Chen Tengda , Xie Zhangkun , Xu Lunshan , Qi Zhen , Guo Xieli 
Published: December 2024

BACKGROUND AND OBJECTIVES:
In conventional freehand frontal ventriculostomy, the Kocher point is the entry point, the external auditory canal is the sagittal target, and the coronal targets include the ipsilateral medial canthus (IMC), the midpoint between the bilateral external auditory meatus (MAM), the contralateral medial canthus (CMC), and the region perpendicular to the skull (P). The aim of this study was to calculate puncture accuracy of the 4 conventional methods to guide clinical selection.

METHODS:
Patient data from thin-slice computed tomography scans were imported, and a 3-dimensional model was reconstructed using software to simulate puncture. The accuracy and puncture depth of the 4 freehand frontal ventriculostomy methods were analyzed.

RESULTS:
From January 1, 2022, to December 30, 2023, 520 patients were screened and 206 were enrolled; 137 (66.5%) participants were males, and 69 (33.5%) were females. The median age of the patients was 64 years (IQR 53-73). The maximal frontal horn width was 21.7-53.7 mm (IQR 34.4-40.0), and the intercanthal distance was 26.0-43.2 mm (IQR 30.7-34.9). Simulating bilateral ventricular puncture, for the IMC trajectory, the puncture accuracy was 13.3% (55/412) [95% CI 10.4-17.0] and the puncture depth was 41.8 ± 4.6 mm. For the MAM trajectory, the puncture accuracy was 74.5% (307/412) [95% CI 70.1-78.5] and the puncture depth was 43.6 ± 4.3 mm. For the P trajectory, the puncture accuracy was 90.5% (373/412) [95% CI 87.3-93.0] and the puncture depth was 49.4 ± 5.9 mm. For the CMC trajectory, the puncture accuracy was 100.0% (412/412) [95% CI 99.1-100.0] and the puncture depth was 47.2 ± 5.2 mm.

CONCLUSION:
Compared with the MAM trajectory, the CMC and P trajectories were more reliable in frontal ventriculostomy, but the P trajectory may enter the contralateral ventricle. The IMC trajectory is not recommended unless the frontal horn is wider than 45 mm or the Kocher point is moved inward.
Μετασχηματίζουσα Μάθηση μέσα από την Αισθητική Εμπειρία: Προσπάθεια εφαρμογής της μεθόδου σε μαθητές Πρωτοβάθμιας Εκπαίδευσης με στόχο την πρόληψη εξαρτητικών συμπεριφορών
Authors: Παππά Ελευθερία 
Published: December 2024

Η επαφή με όλες τις μορφές τέχνης μπορεί να αποτελέσει αποτελεσματικό εργαλείο στην προσπάθεια ενίσχυσης της προσωπικής ανάπτυξης και της διαμόρφωσης υγιών αξιών και στάσεων για τη ζωή του ατόμου. Στόχο της παρούσας εργασίας αποτέλεσε η υλοποίηση και η αξιολόγηση της αποτελεσματικότητας ενός προγράμματος πρόληψης εξαρτητικών συμπεριφορών στο Δημοτικό Σχολείο, το οποίο αξιοποίησε τη μέθοδο «Μετασχηματίζουσα Μάθηση μέσα από την Αισθητική Εμπειρία» ως εργαλείο ενίσχυσης της ψυχικής ανθεκτικότητας και των δεξιοτήτων ζωής των μαθητών. Στην έρευνα συμμετείχαν 109 μαθητές που φοιτούσαν στις δύο τελευταίες τάξεις του Δημοτικού σε Σχολεία της Πάτρας. Στους μαθητές που συμμετείχαν στην εφαρμογή του προγράμματος χορηγήθηκε ερωτηματολόγιο αντιλαμβανόμενης αποτελεσματικότητας του προγράμματος. Η αποτελεσματικότητα του προγράμματος είναι υψηλή στους παράγοντες που αφορούν στις κοινωνικές δεξιότητες, στο ρόλο της τέχνης στην ψυχοκοινωνική υποστήριξη των μαθητών, στην ενημέρωση για εξαρτητικές συμπεριφορές και την πρόληψη, καθώς και στις νέες πληροφορίες και γνώσεις που αποκόμισαν οι μαθητές. Από τα ευρήματα της έρευνας αναδεικνύεται η ανάγκη για το σχεδιασμό συγκεκριμένης εκπαιδευτικής πολιτικής που αφορά στην πρόληψη, μέσα από την εφαρμογή καινοτόμων προγραμμάτων που χρησιμοποιούν εργαλεία όπως η μέθοδος «Μετασχηματίζουσα Μάθηση μέσα από την Αισθητική Εμπειρία», αναγνωρίζοντας με αυτό τον τρόπο το σημαντικό ρόλο που διαδραματίζει το σχολικό περιβάλλον ως ένας προστατευτικός παράγοντας για την πρόληψη της εκδήλωσης εξαρτητικών συμπεριφορών.
Dimensión Espiritual en Materia de Reparación en el Marco del Conflicto Armado Interno Colombiano
Authors: Trujillo Ospina Valeria Isabel 
Published: December 2024

El presente ensayo aborda una propuesta a partir de la hermenéutica jurídica con el fin de explorar la dimensión espiritual, como elemento determinante, en el proceso de reparación integral a las víctimas del conflicto armado interno colombiano. Se plantean cuatro puntos: i. Aproximación del concepto de reparación integral en el ámbito nacional e internacional, con un enfásis especial, en la reparación a través de la indemnidad de la víctima y los estándaresde la jurisprudencia del Sistema Interamericano de Derechos Humanos, como de las cortes locales. ii. Acercamiento al Contexto colombiano, con énfasis en el conflicto y la multiculturalidad.. iii. Explicación de la espiritualidad como dimensión fundamental de la reparación, aunado al hecho que las prácticas sociales y religiosas desempeñan un papel determinante en el manejo del duelo y del perdón como elemento liberador y restaurador de la víctima. Finalmente, se retoma lo analizado, para determinar la importancia de la dimensión espiritual en materia de reparación integral dentro del conflicto interno armado en Colombia.
The Good, the Bad and the Picky: Consumer Heterogeneity and the Reversal of Product Ratings
Authors: Bondi Tommaso , Rossi Michelangelo , Stevens Ryan L. 
Published: December 2024

We study the impact of consumer heterogeneity on online ratings. Consumers differ in their experience, which can affect both their choices and ratings. Thus, biases in average ratings can arise when the opinions of experienced and novice users are aggregated. We first build a two-period model to characterize the biases’ drivers and consequences. We test our theory combining data from IMDb and MovieLens, two well-known movie ratings platforms. We proxy users’ experience with the total number of ratings posted on the platforms. First, using external measures of quality, such as the Academy awards and nominations, we show that, on both platforms, experienced users, on average, rate movies of higher quality compared with novices. Moreover, they post more stringent ratings than novices for more than 98% of movies. Combined, these imply a compression in aggregate ratings, and thus a bias against high quality movies. We then propose a simple, fixed-point algorithm to debias ratings. Our debiased ratings demonstrate the presence of ranking reversals for more than 8% of comparisons in our sample. As a result, our debiased ratings better correlate with external measures of quality. This paper was accepted by Eric Anderson, marketing. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2022.03281 .
Use of a bioactive matrix glove in the treatment of paediatric hand burns: a case series
Authors: Julian Olivia , Agafonoff Slava , Glat Paul M 
Published: December 2024

Objective: Burns to the hand are a common injury in paediatrics and can be traumatic to children, both physically and psychologically. Timely conservative or operative management is critical to maximise healing and minimise long-term complications in these young patients. Here, we present the cases of patients treated with a novel skin substitute formed into a prefabricated glove. The glove (PermeaDerm, Inc., US) is a bioactive matrix composed of a silicone composite membrane embedded with collagen and aloe extract with variable porosity that allows moisture to pass to a secondary dressing. To our knowledge, our group was the first to treat a small set of paediatric patients with hand burns with the glove. Method: A chart review was conducted to analyse hospital course, treatment length, complications and outcomes for each patient. Results: The age range of the five patients included in this case series was seven months to three years. All five patients had scald burns to the hand. Overall, healing with the glove was successful, with little scarring or altered skin pigmentation, and a full range of motion at the affected joints. Conclusion: Hand burns in paediatric patients are traumatic and cumbersome to the patient and their families. This bioactive matrix glove allows for a one-time application, decreases operating room time and need, and reduces the demand for multiple dressing changes. In our set of five patients, the glove showed promising results as a safe and effective noninvasive treatment option for hand burns in paediatric patients.
More-than-human conservation, models from the pluriverse: the example of biocultural diversity conservation from knowledge systems of the Maya Ixil in the Maya Ixil Territory
Authors: D’Alesandro Gina 
Published: December 2024

Central to the more-than-human form of biocultural diversity conservation linked to Maya Ixil practising and living tiichajil and its txaa norms is a more-than-human identity that animates agency beyond the human. Drawing these terms and concepts together, the biodiversity conservation models that they create in their application to the land is an everyday performance and interaction of caretaking with and of diversities of life. This article explores the biocultural, spiritual and cosmological relationships of caretaking in the milpa according to one Indigenous knowledge system that manages the land from embodied, multispecies, networks of reciprocity, that are practised in a peopled, bottom-up model, built in equality, for biocultural diversity’s transmission to next generations.
Emphasised in the analysis of data collected from multispecies ethnography with the Maya Ixil, I argue that expression of these embodied and more-than-human Maya Ixil knowledge systems not only ‘decolonises’ the Ixil from historical and globalised systems of oppression, thereby addressing historical inequalities, but that the other-than-human agencies implicit within them demonstrate a model of relationality articulated through local languages and transgenerational and multispecies biocultural expression in the very real local expressions of the global buen vivir, decolonial and rematriation movement. The Maya Ixil demonstrate not only the theoretical plausibility of forms of community beyond globalised anthropocentric society rooted in colonial structures of inequality, but that the living networks that tiichajil speaks to and txaa guides the human right relation within, provide an alternative model for human behaviour to preserve biodiversity from food systems generating food sovereignties.