bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sociopragmatic factors and melodic patterns: Spanish vocatives and imperatives compared
Authors: Robles-Puente Sergio 
Published: February 2019

AbstractDue to their addressing nature, vocatives and imperatives have been said in multiple occasions to have the same function and similar phonological characteristics. The aim of this paper is to examine the intonational link between these two kinds of sentences in Peninsular Spanish considering sociopragmatic and situational factors like the level of formality and the degree of insistence. In order to do so, twenty-eight native speakers of Peninsular Spanish produced isolated names and verbs in formal and informal settings followed by insistent productions. The phonetic and phonological analyses of 1232 one-word productions indicate that both speech acts share multiple contours; namely L* H%, L + H* HL%, L + H* !H%, L + H* L%, L + H* H%, L + H* LH%. Nevertheless, L + H* L% was the most used contour for both speech acts regardless of the sociopragmatic and situational factors. Interestingly, speakers modified the phonetic properties of intensity and F0 depending on the situation since informal and insistent productions had a higher F0, wider pitch excursions and more intensity than their formal and non-insistent counterparts. As alternatives, L* L% contours were attested in formal imperatives while L + H* LH% and L + H* HL% were more common in informal ones. After L + H* L% contours, L + H* HL% and L* H% were the preferred options in formal vocatives but the latter was hardly attested in informal ones.
Augmented Powell-Based Krill Herd Optimization for Roadside Unit Deployment in Vehicular Ad Hoc Networks
Authors: Saravanan D. , Janakiraman S. , Chandraprabha K. , Kalaipriyan T. , Raghav R. S. , Venkatesan S. 
Published: February 2019

Abstract
This article focuses on roadside unit (RSU) deployment based on the analysis of aggregation delay causes between the accident-occurring location and the nearby RSU. Information aggregation in vehicular ad hoc networks using RSU is one of the phenomenal concepts that look ahead in today’s recent advancements, since the consistency in aggregation and dissemination of data in a volatile network is high when compared with vehicle to vehicle communications. Deploying the RSU as appropriate in rural areas is cost-sensitive since the collection of information is not up to the mark when compared with urban regions. A mathematical model called Powell’s Method and a bioinspired algorithm, namely krill herd algorithm, have been hybridized and proposed in this research article for effective RSU deployment. The proposed algorithm has been tested under three different road maps, and the consistency of the algorithm has been evaluated under appropriate performance measures.
Modeling Heterogeneity in the Genetic Architecture of Ethnically Diverse Groups Using Random Effect Interaction Models
Authors: Veturi Yogasudha , de los Campos Gustavo , Yi Nengjun , Huang Wen , Vazquez Ana I , Kühnel Brigitte 
Published: February 2019

Abstract
In humans, most genome-wide association studies have been conducted using data from Caucasians and many of the reported findings have not replicated in other populations. This lack of replication may be due to statistical issues (small sample sizes or confounding) or perhaps more fundamentally to differences in the genetic architecture of traits between ethnically diverse subpopulations. What aspects of the genetic architecture of traits vary between subpopulations and how can this be quantified? We consider studying effect heterogeneity using Bayesian random effect interaction models. The proposed methodology can be applied using shrinkage and variable selection methods, and produces useful information about effect heterogeneity in the form of whole-genome summaries (e.g., the proportions of variance of a complex trait explained by a set of SNPs and the average correlation of effects) as well as SNP-specific attributes. Using simulations, we show that the proposed methodology yields (nearly) unbiased estimates when the sample size is not too small relative to the number of SNPs used. Subsequently, we used the methodology for the analyses of four complex human traits (standing height, high-density lipoprotein, low-density lipoprotein, and serum urate levels) in European-Americans (EAs) and African-Americans (AAs). The estimated correlations of effects between the two subpopulations were well below unity for all the traits, ranging from 0.73 to 0.50. The extent of effect heterogeneity varied between traits and SNP sets. Height showed less differences in SNP effects between AAs and EAs whereas HDL, a trait highly influenced by lifestyle, exhibited a greater extent of effect heterogeneity. For all the traits, we observed substantial variability in effect heterogeneity across SNPs, suggesting that effect heterogeneity varies between regions of the genome.
Effect of immunoadjuvants on the disease course in patients with operable breast cancer
Authors: Vasilyeva M. M. , Moshurov I. P. , Grivtsova L. Yu. , Tupitsyn N. N. , Kozlov N. A. , Vasilyev M. B. 
Published: February 2019

Background. A new strategy of breast cancer management is required for effective disease prevention and control. Immunotherapy is one of promising options.Objective: to evaluate the effect of immunoadjuvant polyoxidonium on pathmorphological changes in breast tumors.Materials and methods. The study was performed in 75 patients with breast cancer: 50 patients received polyoxidonium in a neoadjuvant regimen (main group), 25 patients did not receive polyoxidonium (control group). Polyoxidonium at a dose of 12 mg was administered intramuscularly 1 time per day on the days 1, 2, 3, 5 and 7 before surgery; on the day 8, radical mastectomy was performed in patients of both groups, followed by histological examination and determination of the grade of therapeutic pathomorphosis of the tumor.Results. The proportion of cases with grade I therapeutic pathomorphosis was 58 %, grade II therapeutic pathomorphosis – 6 %. Pathomorphosis in metastatic lymph nodes was observed in 22.7 % of cases.Conclusion. The anti-tumor effect of polyoxidonium was confirmed on the basis of the induction of pathomorphosis of the tumor tissue of breast cancer.
Efficacy of dose-intensive platinum-containing neoadjuvant chemotherapy in the combination treatment for locally advanced cervical cancer
Authors: Smirnova O. A. , Bondarev N. E. , Ulrikh E. A. , Mikaya N. A. , Petrova A. S. , Abramova A. V. , Ivantsov A. O. , Gorodnova T. V. , Nekrasova E. A. , Lavrinovich O. E. , Sidoruk A. A. , Urmancheeva A. F. , Berlev I. V. 
Published: February 2019

Objective:to assess the efficacy of dose-intensive platinum-containing neoadjuvant chemotherapy in patients with FIGO stage IB2–IIB locally advanced cervical cancer.Materials and methods.We evaluated the efficacy and toxicity of 3 cycles of intravenous dose-intensive neoadjuvant chemotherapy with either AP regimen (cisplatin 75 mg/m2 and doxorubicin 35 mg/m2) or TP regimen (cisplatin 60 mg/m2 and paclitaxel 60 mg/m2).Results.The study included 105 patients (75 in the AP group and 30 in the TP group) aged between 27 and 63 years (mean age 44 years) with primary verified cervical cancer (T1–2B0–2Nx–0M0). Surgery was performed in 66 patients (88 %) from the AP group and 24 patients (80 %) from the TP group. Six patients (8 %) receiving AP regimen and 1 patient (3.3 %) receiving TP regimen developed disease progression. Four women (2.8 %) from the AP group developed relapses, whereas none of the patients from the TP group had relapses. Dose-intensive chemotherapy did not cause any significant complications at both chemotherapeutic and surgical stages. Our findings suggest that dose-intensive neoadjuvant chemotherapy is an effective method with an objective response rate of 84 % (63 cases) and 56.7 % (17 cases) in groups AP and TP respectively. Fifty-nine patients (78.7 %) receiving AP regimen had pathological response; of them, 7 participants (9.4 %) demonstrated pathological complete response (ypCR). In the TP group, 19 patients (63.3 %) had pathological response and 4 patients (13.4 %) had pathological complete response. Median follow-up time was 16.7 months (range: 3–29 months) in the AP group and 9.1 months (range: 2.8–12.7 months) in the TP group.Conclusion.Dose-intensive neoadjuvant chemotherapy can be considered as an alternative to standard treatment of locally advanced cervical cancer; however, further studies are needed due to the small sample size in this study.
İlköğretimde Mesleki Çalışma (Seminer) Dönemi Uygulamaları
Authors: GÜLTEKİN Mehmet , GÜVEY AKTAY Emel , GÜLTEKİN İşıl 
Published: February 2019

Bu
araştırmanın amacı, ilköğretim kurumlarında görev yapan öğretmenlerin seminer
dönemi mesleki çalışmalara yönelik görüşlerini belirlemektir. Nitel yaklaşımla
gerçekleştirilen araştırmaya Eskişehir ilinin Tepebaşı ilçesindeki ilkokul ve
ortaokullarda görev yapan 75 öğretmen katılmıştır. Araştırma verileri açık uçlu
anket yoluyla toplanmış ve betimsel analiz tekniği ile çözümlenmiştir.
Araştırma bulguları bakış açısı, yapılan etkinlikler, beklentiler, eğitim
konuları ve istekler başlığı altında toplanmıştır. Araştırma sonucunda
öğretmenlerin, hizmet içi eğitimleri yararlı bulmadıkları, buna karşın eğitim
sistemindeki değişiklikleri duyurma açısından yararlı buldukları
belirlenmiştir. Öğretmenler mesleki çalışmalar sırasında, akademik yıla ilişkin
hazırlıkların paylaşıldığını, araştırma incelemeye yönelik etkinliklerin
yapıldığını, seminer sürelerinin kısaltılması gerektiğini ve mesleki
çalışmaların branşlara yönelik ve uzmanlar eşliğinde uygulamalı olarak
yapılması gerektiğini görüşlerinde belirtmişlerdir. Bunun yanı sıra
öğretmenlerin mesleki çalışmalarda öğrencilere ve öğretime yönelik, öğretmenin
özlük haklarına ve öğretmenlikle ilgili gelişmelere yönelik konuların yer
alması gerektiği görüşünde oldukları ve bu çalışmaların kolay ulaşılabilir,
öğretmenin bulunduğu ilde ya da sosyal tesislerde yapılmasını istedikleri
ortaya çıkmıştır.
Survey of mobile ad hoc networks (manets)
Authors: Kasem Mohammed Abdulghani Saif , Hamid Bilal Khalid 
Published: February 2019

Mobile Ad Hoc Network (MANET) is the one of the type of ad hoc network, the MANET is a collection of two or more devices or nodes or terminals with wireless communications and networking capability that communicate with each other without the aid of any centralized administrator also the wireless nodes that can dynamically form a network to exchange information without using any existing fixed network infrastructure. And it's an autonomous system in which mobile hosts connected by wireless links are free to be dynamically and sometime act as routers at the same time, In MANET, the mobile nodes require to forward packets for each other to enable communication among nodes outside of transmission range. The nodes in the network are free to move independently in any direction, leave and join the network arbitrarily. Thus a node experiences changes in its link states regularly with other devices. Eventually, the mobility in the ad hoc network, change of link states and other properties of wireless transmission such as attenuation, multipath propagation, interference etc. This paper discuses study of Mobile ad-hoc Networks (MANET): classification, characteristics, structure of MANET and challenges that are imposed by Mobile ad-hoc Networks.
Development of Predictive Antioxidant Models for 1,3,4-Oxadiazoles by Quantitative Structure Activity Relationship
Authors: Alisi Ikechukwu , Uzairu Adamu , Abechi Stephen Eyije , Idris Suleiman Ola 
Published: February 2019

The
free radical scavenging properties of 1,3,4-oxadiazoles have been explored by
the application of quantitative structure activity relationship (QSAR) studies.
The entire data set of the oxadiazole derivatives were minimized and
subsequently optimized at the density functional theory (DFT) level in combination
with the Becke's three-parameter Lee-Yang-Parr hybrid functional (B3LYP) hybrid
functional and 6-311G* basis set. Kennard
Stone algorithm was employed in data division into training and test
sets. The training set were employed in QSAR model development by genetic
function algorithm (GFA), while the test set were used to validate the
developed models. The applicability domain of the developed model was accessed
by the leverage approach. The varation inflation factor, degree of contribution
and mean effect of each descriptor were calculated. Quantum chemical and molecular descriptors
were generated for each molecule in the data set. Five predictive models that
met all the requirements for acceptability with good validation results were
developed. The best of the five models gave the following validation results:

,

,

and c

, rmsep

. The QSAR analysis revealed that the sum of
e-state descriptors of strength for potential hydrogen bonds of path length 9 (SHBint9)
and topological radius (topoRadius) are the most crucial descriptors that influence
the free radical scavenging activities of
1,3,4-oxadiazole derivatives.
IMMUNOLOGICAL CHANGES IN THE INVASION OF HELICOBACTER PYLORI: PROSPECTS FOR CREATING VACCINES
Authors: Uspenskiy Yu. P. , Gorbacheva I. A. , Suvorov A. N. , Galagudza M. M. , Baryshnikova N. V. , Bogdanova S. A. 
Published: February 2019

In this article we wrote about main immunologic disorders in Helicobacter pylori infected patients (changes of local, cell and humoral immunity). We have our own data about changes of interleukins 1β, 4 and 8 level in cagA(+) and cagA(−) Helicobacter pylori strains infected patients: we saw that level of proinflammatory interleukin-1β and unterleukin-8 are higher and level of anti-inflammatory interleukin-4 are lower in patients infected cagA(+) strains of Helicobacter pylori. We demonstrated results of different studies about efficacy of anti-Helicobacter pylori vaccines as immunologic prophylaxis of this microorganism invasion: usage of mucosal adjuvants and usage of immunostimulating probiotics during vaccination have promising results.
Pain Assessment in Intensive Care Nursing and Nursing Management
Authors: ŞAPULU ALAKAN Yeliz , ÜNAL Edibe 
Published: February 2019

Some evidence suggests that nonverbal patients experience
stressful, unpleasant, and potentially negative experiences during their time
in intensive care units. These include pain, fear, sleep deprivation,
nightmares, inability to speak, and feelings of isolation and loneliness. Among
these negative experiences, pain has emerged as a leading stressor for
intensive care units patients. The
patient self report is the most reliable source of pain assesment, intensive
care unit&nbsp; patients are unable to self
report because of intubation and sedation. For this reason, there must be
scales which include verbal and non-verbal parameters, behavioral responses to
pain in intensive care units. Critical care nurses play the most important role
in evaluation and relief of pain in intensive care patients since they are the
staff who spend time most with the patients and follow them closely.
Otizm Spektrum Bozukluğunda Endokrin Bozucuların Rolü Var mıdır?
Authors: İLHAN Azad , AYAZ Aylin 
Published: February 2019

İnsan sağlığı ve neslinin devamı metabolizma, büyüme-gelişme,
zihinsel işlevler, bağışıklık sistemi ve üreme için yaşamsal rolü bulunan
hormon ve benzeri sinyal taşıyıcı maddelerin kusursuz çalışmasına bağlıdır. Bebekler ve küçük çocuklar yetişkinlere oranla besinlerdeki kirleticilere daha duyarlıdır. Bebeklik ve erken çocukluk döneminde endokrin bozuculara maruz kalmak, çocukluk çağı hastalıklarının gelişimi açısından önemlidir. Prenatal dönemde bebekler plasenta yoluyla kirleticilere maruz kalabilirler. Bu maruziyet
sonucunda, vücudun endokrin sistemi
etkilenip, nörolojik, üreme, kardiyovasküler, metabolik ve bağışıklık sistemi
üzerine olumsuz etkiler ortaya çıkmaktadır. Endokrin
bozucular östrojen, androjenler ve tiroid hormonlarının etkisini değiştirerek
etki gösterebilir. Otizm spektrum bozukluğu (OSB) yaşam boyu devam eden ve
genellikle tahrip edici etkisi olan, hem bu hastalığa sahip bireyi hem de tüm
ailesini önemli düzeyde etkileyen bir durumdur. OSB’ye neden olan faktörler
kesin olarak bilinmemekle birlikte genetik temelli olduğu bildirilmiştir.
Çevresel faktörlerin de OSB’ye neden olabileceği düşünülmektedir. Hem genetik
faktörlerin hem de çevresel faktörlerin etkileri üzerine çok sayıda araştırma
yapılmaktadır. Son dönemde yapılan çalışmalarda, gebe kadınların vücut
sıvılarının (idrar, serum) endokrin bozucu madde içerikleri ile ölçülen
kimyasalların prenatal vücut yüküne ve bunların çocuklara olan etkisi ve OSB
ile ilişkisine bakılmaktadır. Endokrin bozucuların OSB ile ilişkisi üzerine
çalışmalar olmasına rağmen bu konuda daha fazla çalışmaya gerek duyulmaktadır. Bu derleme yazıda OSB ve endokrin bozucular arasındaki olası ilişkinin güncel çalışma sonuçlarına göre değerlendirilmesi amaçlanmıştır.
Fear and disgust: case report of two uncommon emotional disturbances evoked by visual disperceptions after a right temporal-insular stroke
Authors: Cantone Mariagiovanna , Lanza Giuseppe , Bella Rita , Pennisi Giovanni , Santalucia Paola , Pennisi Manuela 
Published: February 2019

Abstract
Background: emotional processes and responses are underestimated in stroke patients because these symptoms are often hidden by the massive clinical picture of large hemispheric strokes. We report on a patient with peculiar unpleasant emotional responses after temporal stroke.
Case presentation: we describe a 62-years old man with significant unpleasant emotional responses that occurred after an acute episode of confusional state, disorientation, agitation, vertigo, postural instability, vomiting, and photophobia. Since then, he complained that vision of pictures containing curved/multicolored lines or tangles was associated with an uncomfortable feeling of fear and disgust, so that he avoided to look at them. Notably, he also showed an abnormal facial expression of disgust and fear, together with neurovegetative reaction and horripilation, at the presentation of pictures of objects or animals containing curved, multicolored, or tangled lines. A post-acute infarction of the right temporal-insular region, together with mild periventricular white matter changes, were evident at the brain magnetic resonance imaging.
Conclusions: the anterior insula is crucial in transforming unpleasant sensory input into visceromotor reactions and the accompanying feeling of disgust. It is also known that temporal pole modulates visceral emotional functions in response to emotionally evocative perceptual stimuli. In the present case, the ischemic lesion of anterior part of the insula and temporal pole may have caused a decoupling of emotional and visceral response to complex visual stimuli. Further reports will provide a significant contribution to the taxonomy of these complex and relatively uncommon non-motor post-stroke symptoms that negatively impact quality of life.
A comparative study in aquifer parameter estimation using MFree point collocation method with evolutionary algorithms
Authors: Thomas Alice , Eldho T. I. , Rastogi A. K. , Majumder Partha 
Published: February 2019

Abstract
In this study, we present a comparative assessment of simulation-optimization (S-O) models to estimate aquifer parameters such as transmissivity, longitudinal dispersivity, and transverse dispersivity. The groundwater flow and contaminant transport processes are simulated using the mesh-free radial basis point collocation method (RPCM). Four different S-O models are developed by combining the RPCM model separately with genetic algorithm (GA), differential evolution (DE), cat swarm optimization (CSO), and particle swarm optimization (PSO). The objective of the S-O model is to minimize a composite objective function with transmissivity, longitudinal dispersivity, and transverse dispersivity as decision variables. Hydraulic head and contaminant concentration at observation points are the state variables. The S-O models are used to estimate aquifer parameters of a confined aquifer with nine zones. It is found that RPCM-based DE, CSO, and PSO models are more accurate in estimating aquifer parameters than RPCM-GA. However, for noisy observed data, the RPCM-CSO model outperforms other models. The efficiency of the RPCM-CSO model over other models is further established by performing reliability analysis to the noisy observed data set. The comparative study reflects the efficacy of CSO over GA, DE, and PSO.
Evaluation of biocidal efficacy of Chloramine T trihydrate on planktonic and sessile bacteria in a model cooling tower water system
Authors: Sanli Nazmiye Ozlem 
Published: February 2019

Abstract
A model cooling tower system was experimentally seeded with Legionella pneumophila and real industrial cooling tower (CT) water has been run at the closest to full-scale system operating conditions. The water/biofilm samples were taken from the model system monthly, and the effectiveness of the different concentrations of Chloramine T trihydrate biocide was evaluated in terms of its ability to control both planktonic/sessile microbial populations. Although Chloramine T is a recommended commercial formulation for disinfecting CTs, there is a lack of published data on the efficacy of this compound against both planktonic and sessile populations in the cooling tower. Biocide response in both sessile/planktonic bacteria counts varied according to months. Tested biocide concentrations provided the clean tower conditions by reducing the concentration of heterotrophic plate count (HPC) below &lt;104 cfu mL−1, L. pneumophila &lt;10 cfu mL−1 and of adenosine triphosphate (ATP) values &lt;300 relative light units (RLU), after 1, 3 and 24 h of exposure, during a 6-month period. There were no statistically significant differences in efficacy between concentrations in terms of reduction in the number of bacteria, decrease in ATP value and viability. The results revealed that Chloramine T can effectively control biofouling in cooling systems according to the limit values of the successful control program.
Raça, Gênero e Saberes dos Povos da África na Difusão do Arroz Oryza glaberrima
Authors: Vital André Vasques 
Published: February 2019

Resenha do Livro
Carney JA 2018. Arroz negro: as origens africanas do cultivo do arroz nas Américas. Instituto da Biodiversidade e das Áreas Protegidas, Bissau, 359 pp.
A Facile, Efficient and Selective Deprotection of P - Methoxy Benzyl Ethers Using Zinc (II) Trifluoromethanesulfonate
Authors: Sireesha Reddymasu , Sreenivasulu Reddymasu , Chandrasekhar Choragudi , Rao Mannam Subba 
Published: February 2019

:
Deprotection is significant and conducted over mild reaction conditions, in order to restrict
any more side reactions with sensitive functional groups as well as racemization or epimerization of
stereo center because the protective groups are often cleaved at last stage in the synthesis. P - Methoxy
benzyl (PMB) ether appears unique due to its easy introduction and removal than the other benzyl ether
protecting groups. A facile, efficient and highly selective cleavage of P - methoxy benzyl ethers was
reported by using 20 mole% Zinc (II) Trifluoromethanesulfonate at room temperature in acetonitrile
solvent over 15-120 min. time period. To study the generality of this methodology, several PMB ethers
were prepared from a variety of substrates having different protecting groups and subjected to deprotection
of PMB ethers using Zn(OTf)2 in acetonitrile. In this methodology, zinc triflate cleaves only
PMB ethers without affecting acid sensitivity, base sensitivity and also chiral epoxide groups.