bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water percolation in a thick unsaturated loess layer considering the ground‐atmosphere interaction
Authors: Hou Xiaokun , Li Tonglu , Vanapalli Sai K. , Xi Yu 
Published: December 2018

AbstractThe key objective of this paper is to advance our present understanding of how surface water infiltrates in thick unsaturated loess, which is found in arid and semiarid regions of the world, considering the ground‐atmosphere interaction. In situ data for a period of 1 year in thick loess layer at a site in the Loess Plateau of China that has groundwater table at 97.5 m depth were collected for achieving this objective. Climate factors, mainly rainfall and actual evaporation, were measured. In addition, variations of soil temperature and water content at different depths in the unsaturated zone were also measured. The data were used to interpret the water percolation characteristics by dividing the thick unsaturated zone into three zones; namely, (i) surface zone, which constitutes the top 1.0 m, (ii) unsteady zone, which is from 1.0 to 7.0 m, and (iii) steady zone, which is below 7.0 m. In the surface zone, soil temperature and water content are sensitive to climate factors. There is a variation of water content associated with the cumulative influence of infiltration and evaporation in the precipitation and nonprecipitation periods, respectively. In the unsteady zone, the water content is relatively constant; however, temperature varies in different seasons. Water percolation in this zone is both in liquid and vapour phases. In the steady zone, both soil temperature and water content are constant during the entire investigation period. The percolation velocity in this zone is approximately 1.23 × 10−8 m/s or 0.39 m/year, which suggests that it will take approximately 230.8 years for surface water to pass through the thick unsaturated zone and recharge the groundwater.
Retracted: MicroRNA‐217 relieved neuropathic pain through targeting toll‐like receptor 5 expression
Authors: Jiang Wanwei , Wang Qinghui , Yu Xuemei , Lu Tong , Zhang Pengbo 
Published: December 2018

AbstractNeuropathic pain is the most common chronic pain that is caused by nerve injury or disease that influences the nervous system. Increasing evidence suggested that microRNAs (miRNAs) play a crucial role in neuropathic pain and neuroinflammation development. However, the functional role of miR‐217 in the development of neuropathic pain remains unknown. In this study, we used rats to establish a neuropathic pain model and showed that the miR‐217 expression level was upregulated in the spinal dorsal horn of bilateral sciatic nerve chronic constriction injury (bCCI). However, the expression of miR‐217 was not changed in the anterior cingulated cortex (ACC), hippocampus, and dorsal root ganglion (DRG) of bCCI rats. Ectopic expression of miR‐217 attenuated neuropathic pain and suppressed neuroinflammation expression in vivo. We identified toll‐like receptor 5 (TLR5) as a direct target gene of miR‐217 in the PC12 cell. In addition, we demonstrated that the expression level of TLR5 was upregulated in bCCI rats. Moreover, restoration of TLR5 rescued the inhibitory roles induced by miR‐217 overexpression on neuropathic pain and neuroinflammation development. These data suggested that miR‐217 played a pivotal role in the development of neuropathic pain partly through regulating TLR5 expression.
LINC01133 aggravates the progression of hepatocellular carcinoma by activating the PI3K/AKT pathway
Authors: Zheng Yong‐Fa , Zhang Xiao‐Yu , Bu Yan‐Zhi 
Published: December 2018

AbstractLncRNAs exhibit crucial roles in various pathological diseases, including hepatocellular carcinoma (HCC). Therefore, it is significant to recognize the dysregulated lncRNAs in HCC progression. Recently, LINC01133 has been identified in several tumors. However, the biological role of LINC01133 in HCC remains poorly understood. Currently, we focused on the function of LINC01133 in HCC development. We observed that LINC01133 was significantly increased in HCC cells including HepG2, Hep3B, MHCC‐97L, SK‐Hep‐1, and MHCC‐97H cells compared with the normal human liver cell line HL‐7702. In addition, PI3K/AKT signaling was highly activated in HCC cells. Knockdown of LINC01133 was able to inhibit HCC cell proliferation, cell colony formation, cell apoptosis, and blocked cell cycle arrest in the G1 phase. For another, downregulation of LINC01133 repressed HCC cell migration and invasion. Subsequently, the PI3K/AKT signaling pathway was strongly suppressed by silence of LINC01133 in Hep3B and HepG2 cells. Then, in vivo tumor xenografts models were established using Hep3B cells to explore the function of LINC01133 in HCC progression. Consistently, our study indicated that knockdown of LINC01133 dramatically repressed HCC tumor progression through targeting the PI3K/AKT pathway in vivo. Taken these together, we revealed that LINC01133 contributed to HCC progression by activating the PI3K/AKT pathway.
Identification of 4‐lncRNA prognostic signature in head and neck squamous cell carcinoma
Authors: Diao Pengfei , Song Yue , Ge Han , Wu Yaping , Li Jin , Zhang Wei , Wang Yanling , Cheng Jie 
Published: December 2018

AbstractDeregulated long noncoding RNAs (lncRNA) have been critically implicated in tumorigenesis and serve as novel diagnostic and prognostic biomarkers. Here we sought to develop a prognostic lncRNA signature in patients with head and neck squamous cell carcinoma (HNSCC). Original RNA‐seq data of 499 HNSCC samples were retrieved from The Cancer Genome Atlas database, which was randomly divided into training and testing set. Univariate Cox regression survival analysis, robust likelihood‐based survival model and random sampling iterations were applied to identify prognostic lncRNA candidates in the training cohort. A prognostic risk score was developed based on the Cox coefficient of four individual lncRNA imputed as follows: (0.14546 × expression level of RP11‐366H4.1) + (0.27106 × expression level of LINC01123) + (0.54316 × expression level of RP11‐110I1.14) + (−0.48794 × expression level of CTD‐2506J14.1). Kaplan‐Meier analysis revealed that patients with high‐risk score had significantly reduced overall survival as compared with those with low‐risk score when patients in training, testing, and validation cohorts were stratified into high‐ or low‐risk subgroups. Multivariate survival analysis further revealed that this 4‐lncRNA signature was a novel and important prognostic factor independent of multiple clinicopathological parameters. Importantly, ROC analyses indicated that predictive accuracy and sensitivity of this 4‐lncRNA signature outperformed those previously well‐established prognostic factors. Noticeably, prognostic score based on quantification of these 4‐lncRNA via qRT‐PCR in another independent HNSCC cohort robustly stratified patients into subgroups with high or low survival. Taken together, we developed a robust 4‐lncRNA prognostic signature for HNSCC that might provide a novel powerful prognostic biomarker for precision oncology.
R1 resection of colorectal liver metastasis – What is the cost of marginal resection?
Authors: Pencovich Niv , Houli Rotem , Lubezky Nir , Goykhman Yaacov , Nakache Richard , Klausner Joseph M. , Nachmany Ido 
Published: December 2018

Background and objectivesThe impact of resection margins on the outcome of patients with colorectal liver metastasis (CRLM) remains controversial. We evaluated the short and long‐term results of R1 resection.MethodsBetween 2006 and 2016, 202 patients underwent liver resection for CRLM. R1 resection was defined as a distance of less than 1 mm between tumor cells and the transection plain. Patient and tumor characteristics, perioperative, and long‐term outcomes were assessed.ResultsIn 161 (79.7%) and 41 (20.3%) patients, an R0 and R1 resections were achieved, respectively. Patients that underwent an R1 resection had higher rates of disease progression while on chemotherapy (12.1% vs 5.5%, P = 0.001), need for second‐line chemotherapy (17% vs 6.2%, P < 0.001), increased use of preoperative volume manipulation (14.6% vs 5.5%, P = 0.001), and inferior vena‐cava involvement (21.9% vs 8.7%, P < 0.001). These patients had higher rates of major postoperative complications (19.5% vs 6.8%, P < 0.001) and reoperations (7.3% vs 2.4%, P < 0.001). Multivariate analysis demonstrated that R1 resections were not associated with decreased recurrence‐free survival or overall survival.ConclusionsAlthough R1 resection is associated with worse disease behavior and postoperative complications, the long‐term outcome of patients following an R1 resection is non‐inferior to those who underwent an R0 resection.
Torsion‐dependent spectral response of long‐period fiber grating based on electric arc technique with axial rotation of the fiber
Authors: Delgado Felipe , Bessa Alexandre 
Published: December 2018

AbstractWe present a novel technique for manufacturing a long‐period fiber grating (LPFG) with enhanced torsion sensitivity based on electric arc technique. The proposed method rotates the fiber around its axis of rotation at each electric arc discharge. We experimentally investigated the torsion‐dependent spectral response of the produced grating and the results showed that an enhanced linear torsion sensitivity up to 0.197 nm/(rad/m) was achieved, which is higher than that of the conventional arc‐induced LPFGs.
Determining success rates of the current pharmacokinetically guided dosing approach of topotecan in pediatric oncology patients
Authors: Mitchell Anna Birg , Vasilyeva Aksana , Gajjar Amar , Santana Victor M. , Stewart Clinton F. 
Published: December 2018

AbstractBackgroundTopotecan is a chemotherapeutic agent that is active against many pediatric tumors. Although its effect is related to systemic exposure, the interpatient variability in systemic clearance makes it challenging to achieve desired topotecan targets. This study aims to evaluate the success of the pharmacokinetically (PK) guided dosing process, which was used to achieve a target topotecan area under the concentration‐time curve (AUC).MethodsPatients received an empiric topotecan dosage on the first day; the topotecan lactone AUC was determined, and based upon these values the topotecan dosage was adjusted. The success rates of both the empiric and PK‐guided strategies were calculated. Patient‐specific covariates were collected to explain variability observed in the empiric and PK‐guided results. A simulation study was performed to assess the differences in cumulative topotecan dosage and systemic exposure between a PK‐guided and standard dosing approach.ResultsData were collected from nine clinical trials open from 1996 to 2016 (n = 232 patients). The empiric dosing success rate was 35.5%, while the PK‐guided rate was 64.4%. A difference in mean serum creatinine was observed between successful empiric studies and those above the AUC target. Compared to a standard dosing approach, the PK‐guided group had a higher average cumulative dosage and systemic exposure.ConclusionThe low empiric dosing success rate indicates that additional studies are needed to refine the initial topotecan dosage. The role of renal function, measured as serum creatinine, remains to be elucidated. However, the PK‐guided targeting success rate highlighted the need to account for variable topotecan systemic clearance.
Contemporary Management of Direct Oral Anticoagulants During Cardioversion and Ablation for Nonvalvular Atrial Fibrillation
Authors: Trujillo Toby C. , Dobesh Paul P. , Crossley George H. , Finks Shannon W. 
Published: December 2018

As overall prevalence of atrial fibrillation (AF) continues to rise, the number of patients who undergo ablation, or electrical/chemical cardioversion, to restore normal sinus rhythm continues to increase as well. As direct oral anticoagulants (DOACs) have continued to be incorporated into clinical practice for long‐term anticoagulation for AF, experience with how best to manage use of DOACs during electrophysiologic procedures is evolving. This review is intended to provide health care providers with a summary of current evidence regarding the use of DOACs during cardioversion and catheter ablation and provide key considerations for their use during such electrophysiologic procedures. PubMed and MEDLINE were searched from inception through June 2018 for studies in humans comparing DOACs alone or against vitamin K antagonists (VKAs) in adult patients (> 18 yrs) who underwent cardioversion or AF catheter ablation using the following key words: “rivaroxaban,” “dabigatran,” “apixaban,” “edoxaban,” “non–vitamin K antagonists,” “direct or new oral anticoagulants,” “warfarin,” “vitamin K antagonists,” “cardioversion,” “ablation of atrial fibrillation,” “uninterrupted,” and “catheter ablation.” Four retrospective studies and three prospective trials comparing DOACs with VKA in patients undergoing cardioversion and three prospective studies in patients undergoing catheter ablation for AF were identified. Observational data and meta‐analyses were also critically reviewed. Prospective trials to date suggest similar efficacy and safety with using DOACs in the setting of cardioversion and AF ablation compared to traditional therapy with VKA, with or without bridging. Injectable anticoagulant overlap can be avoided in patients receiving DOACs in the setting of cardioversion for AF. Minimal interruption in anticoagulation may be only necessary for AF ablation in those with highest bleeding risk, such as in renal dysfunction and where drug‐drug interactions may increase risk for anticoagulant accumulation. Periprocedural advantages of DOACs include convenience, rapid and predictable onset of effect, improved patient satisfaction, and potential for reduced costs.
African biogeographical ancestry, atopic and non‐atopic asthma and atopy: A study in Latin American children
Authors: da Silva Thiago M. , Fiaccone Rosemeire L. , Kehdy Fernanda S. G. , Tarazona‐Santos Eduardo , Rodrigues Laura C. , Costa Gustavo N. O. , Figueiredo Camila A. , dos Santos Darci N. , Feitosa Caroline A. , Fattore Gisel L. , Santos Leticia M. , Alcantara‐Neves Neuza M. , Cruz Álvaro A. , Barreto Maurício L. 
Published: December 2018

AbstractBackgroundGenetic variants underlying African ancestry have been suggested be implicated in the ethnic‐racial inequalities reported for asthma and allergies.ObjectivesTo investigate the association between individual African ancestry and asthma symptoms, atopic and non‐atopic asthma, and atopy in children.MethodsA cross‐sectional study encompassing 1190 individuals was conducted. African biogeographic ancestry was estimated using 370 539 genome‐wide SNPs. Serum levels of specific IgE were measured, and skin prick test (SPT) performed for the most common local aeroallergens. Information on asthma symptoms was obtained by applying the International Study of Allergy and Asthma in Childhood questionnaire. The associations between the proportion of individual African ancestry and the outcomes investigated were analyzed through multivariate models adjusted for socio‐environmental variables, infections markers, and psychosocial factors.ResultsEach 20% increase in the proportion of African ancestry was negatively associated with SPT reactivity (OR: 0.79, 95%CI: 0.66‐0.96) and positively associated with asthma symptoms in non‐atopic individuals (OR: 1.40, 95%CI: 1.03‐1.89). We estimated that socioeconomic status and number of infections mediated 28.4% of the effect of African ancestry on SPT reactivity, while 20.2% of the effect on non‐atopic asthma was explained by socioeconomic status and behavioral problems in children.ConclusionsThe negative association observed between African ancestry and atopy is most probably explained by unobserved environmental or social factors that covariate with ancestry. For non‐atopic asthma, in turn, putative genetic variants of risk underlying African ancestry may play some role.
Exploring the first‐shell and second‐shell structures arising in the microsolvation of Li+ by rare gases
Authors: Jesus Wanderson S. , Marques Jorge M. C. , Prudente Frederico V. , Pereira Francisco B. 
Published: December 2018

AbstractAn evolutionary algorithm was used to search for the low‐energy structures of Li+Arn and Li+Krn (n = 1 − 14). Two functions were used to describe the interaction potential at the CCSD(T)/aug‐cc‐pVQZ level of theory: one is based on a sum of all pair potentials, whereas the other includes three‐body interactions. In general, the global minimum structures are similar for both Li+Arn and Li+Krn. Modifications in the octahedral structure of the first solvation shell lead to a high‐energy penalty. Conversely, the second solvation shell shows a panoply of minima with similar energies that are likely to be interconverted. Post‐optimization at the MP2 level confirmed that, for n = 2 and 3, one has to include three‐body terms in the potential to reproduce the low‐energy structures. Additionally, MP2 calculations indicate that energy reorder of the global minimum structure observed for Li+Kr8 is related to the Kr3 Axilrod‐Teller‐Muto term included in the potential.
Bound anionic states of DNA and RNA nucleobases: An EOM‐CCSD investigation
Authors: Tripathi Divya , Dutta Achintya Kumar 
Published: December 2018

AbstractIn this article, we have studied the bound anionic states of DNA and RNA nucleobases using the newly developed bt‐PNO‐EOM‐CCSD method and extended basis sets. All of the five nucleobases have a single bound anionic state, which is dipole bound in nature. The electron affinity corresponding to the dipole‐bound state is found to be extremely sensitive to the used basis set, and a proper agreement with the available experimental data requires a large basis set with a sufficient number of diffuse functions. Electron correlation plays a major role in stabilizing the bound anionic states of nucleobases. No valence‐bound anionic states are observed for any of the nucleobases.
Front delineation and tracking with multiple underwater vehicles
Authors: Branch Andrew , Flexas Mar M. , Claus Brian , Thompson Andrew F. , Zhang Yanwu , Clark Evan B. , Chien Steve , Fratantoni David M. , Kinsey James C. , Hobson Brett , Kieft Brian , Chavez Francisco P. 
Published: December 2018

AbstractThis study describes a method for detecting and tracking ocean fronts using multiple autonomous underwater vehicles (AUVs). Multiple vehicles, equally spaced along the expected frontal boundary, complete near parallel transects orthogonal to the front. Two different techniques are used to determine the location of the front crossing from each individual vehicle transect. The first technique uses lateral gradients to detect when a change in the observed water property occurs. The second technique uses a measure of the vertical temperature structure over a single dive to detect when the vehicle is in upwelling water. Adaptive control of the vehicles ensure they remain perpendicular to the estimated front boundary as it evolves over time. This method was demonstrated in several experiment periods totaling weeks, in and around Monterey Bay, CA, in May and June of 2017. We compare the two front detection methods, a lateral gradient front detector and an upwelling front detector using the Vertical Temperature Homogeneity Index. We introduce two metrics to evaluate the adaptive control techniques presented. We show the capability of this method for repeated sampling across a dynamic ocean front using a fleet of three types of platforms: short‐range Iver AUVs, Tethys‐class long‐range AUVs, and Seagliders. This method extends to tracking gradients of different properties using a variety of vehicles.
Geometry of large Boltzmann outerplanar maps
Authors: Stefánsson Sigurdur Örn , Stufler Benedikt 
Published: December 2018

We study the phase diagram of random outerplanar maps sampled according to nonnegative Boltzmann weights that are assigned to each face of a map. We prove that for certain choices of weights the map looks like a rescaled version of its boundary when its number of vertices tends to infinity. The Boltzmann outerplanar maps are then shown to converge in the Gromov‐Hausdorff sense towards the α‐stable looptree introduced by Curien and Kortchemski (2014), with the parameter α depending on the specific weight‐sequence. This allows us to describe the transition of the asymptotic geometric shape from a deterministic circle to the Brownian tree.
Recent Advances in 3D Graphene Architectures and Their Composites for Energy Storage Applications
Authors: Wang Zhijie , Gao Hong , Zhang Qing , Liu Yuqing , Chen Jun , Guo Zaiping 
Published: December 2018

AbstractGraphene is widely applied as an electrode material in energy storage fields. However, the strong π–π interaction between graphene layers and the stacking issues lead to a great loss of electrochemically active surface area, damaging the performance of graphene electrodes. Developing 3D graphene architectures that are constructed of graphene sheet subunits is an effective strategy to solve this problem. The graphene architectures can be directly utilized as binder‐free electrodes for energy storage devices. Furthermore, they can be used as a matrix to support active materials and further improve their electrochemical performance. Here, recent advances in synthesizing 3D graphene architectures and their composites as well as their application in different energy storage devices, including various battery systems and supercapacitors are reviewed. In addition, their challenges for application at the current stage are discussed and future development prospects are indicated.
A Freestanding Stretchable and Multifunctional Transistor with Intrinsic Self‐Healing Properties of all Device Components
Authors: Khatib Muhammad , Huynh Tan‐Phat , Deng Yunfeng , Horev Yehu David , Saliba Walaa , Wu Weiwei , Haick Hossam 
Published: December 2018

AbstractA flexible and stretchable field‐effect transistor (FET) is an essential element in a number of modern electronics. To realize the potential of this device in harsh real‐world conditions and to extend its application spectrum, new functionalities are needed to be introduced into the device. Here, solution‐processable elements based on carbon nanotubes that empower flexible and stretchable FET with high hole‐mobility (µh ≈ 10 cm2 V−1 s−1) and relatively low operating voltages (<8 V) and that retain self‐healing properties of all FET components are reported. The device has repeatable intrinsic and autonomic self‐healing ability, namely without use of any external trigger, enabling the restoration of its electrical and mechanical properties, both after microscale damage or complete cut of the device—for example by a scissor. The device can be repeatedly stretched for >200 cycles of up to 50% strain without a significant loss in its electrical properties. The device is applicable in the form of a ≈3 µm thick freestanding skin tattoo and has multifunctional sensing properties, such as detection of temperature and humidity. With this unprecedented biomimetic transistor, highly sustainable and reliable soft electronic applications can be introduced.