bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparative Study on Mathematical Culture of My Country’s New Version of High School Mathematical Textbooks—Take the Content of Functions in the Compulsory Textbooks of the People’s Education a and Hunan Education Editions as Examples
Authors: Wang Peipei , Wen Jianhong 
Published: November 2024

AbstractThe research takes the function topics in the compulsory textbooks of the People's Education Edition A and the Hunan Education Edition as examples, and compares and analyzes the column distribution, cultural type, application level and cultural function of their mathematics culture. Through the conclusion, it puts forward suggestions to improve the setting of mathematics culture in Chinese textbooks.
Math Textbooks Use: Explicit and Implicit Influence for Teachers and Students
Authors: Wang Yihan , Liu Xiaomei , Yang Junna 
Published: November 2024

AbstractAs an important teaching resource in curriculum implementation, textbooks are one of the main mediums for teachers to teach and students to learn. Based on Rezat’s tetrahedron model of the activity “textbook use” and the theme of this study, this paper selects “student—teacher—textbook”, “teacher—textbook—mathematical knowledge” and “student—teacher—mathematical knowledge” as the three dimensions of the study. A questionnaire was compiled by conducting a survey and an interview of the junior high school teachers who use the mathematics textbooks of Beijing Normal University in more than a dozen provinces and cities in China. The paper analyzes the explicit influence of textbooks on teachers’ teaching design and selection of teaching methods in the teaching process, the implicit influence of textbook writing concepts on enriching teachers’ pedagogical knowledge. Based on the research results, relevant suggestions have been put forward from the aspects of textbook compilation concept, compilation content and teaching resources development which give full play to the explicit and implicit influence of textbooks in mathematics teaching.
A Comparative Analysis of the Linear Equation Unit in Secondary Mathematics Textbooks in Chinese-English Bilingual Schools
Authors: Xu Xiaoyu , Zhang Qiaoping 
Published: November 2024

AbstractChinese–English bilingual programs in China advocate using both English and Chinese in instruction. Mathematics teachers in these schools need to use English as the medium of instruction to achieve the learning objectives of the school mathematics curriculum and also meet the English proficiency goals. Mathematics textbooks play a crucial role in teaching and learning within such a learning environment. This study presents a comparative study aiming to examine how linear equation unit is arranged in secondary school mathematics textbooks (i.e., IB, IGCSE, and Chinese textbooks) in Chinese-English bilingual schools. It explores the similarities and differences in these three series of textbooks. Four aspects of linear equations in different textbooks are compared: the number of examples, the distribution of contents, the learning activities, chapter review exercises. The results show that the three textbooks have different approaches and priorities that emphasize the positions and weights of the linear equation unit. The textbooks in China contain the highest percentage of linear equation contents and pay the most attention to explaining and analyzing how to set the unknown variable and using the concept of the linear equation to solve real-life problems. The findings can enrich teachers’ and researchers’ knowledge of mathematics textbooks in international schools in China and put forward some suggestions to improve the effectiveness of using textbooks in such schools.
A Comparative Study on the Difficulty of the Exercises in the Textbooks of the Distributive Law of Multiplication
Authors: Zhao Shaotang , Liu Sa 
Published: November 2024

AbstractFour levels of the difficulty of the distributive law of multiplication are established (including the operational memory level, the conceptual memory level, the explanatory understanding level and the exploratory understanding level). Based on this, this paper makes a comparative analysis of the exercises of the distributive law of multiplication in the six editions of the textbooks. The conclusions are as follows: The total amount of exercises in different textbooks varies greatly, the amount and proportion of exercises at the same level vary greatly. And in light of that, it is necessary to establish difficulty classification standards for exercises research and carefully consider the total quantity and the number of exercises of different levels. Meanwhile, teachers should add and subtract exercises of different levels according to the learning conditions.
A Study on the Primary School Mathematics Teachers’ Attention Regarding the Adoption of NCM Textbooks
Authors: Feng Pingting , Liu Jian 
Published: November 2024

AbstractTextbook is one of the most important resources for teachers to implement teaching, teacher’s attention to the textbooks profoundly effects their teaching practice. Based on the Concern-based Adoption Model, according to the theme of teachers’ attention of NCM textbook, a six-stage model is established, including the attention stages of information acquisition, personal competence, management and control, student results, collaborative study and reflection evaluation. Revised stage of attention questionnaire was used to investigate the current situation of primary school mathematics teachers’ NCM textbooks attention, and explore whether and how different teachers care of the textbooks. Then through the investigation of typical teachers, we found ways to improve the teachers’ attention of NCM textbooks, so as to lay the foundation for teachers to use textbooks better and implement the concept of curriculum reform thoroughly.
Racial and ethnic disparities in the uptake of SGLT2is and GLP-1RAs among Medicare beneficiaries with type 2 diabetes and heart failure, atherosclerotic cardiovascular disease and chronic kidney disease, 2013–2019
Authors: Wang Eric , Patorno Elisabetta , Khosrow-Khavar Farzin , Crystal Stephen , Dave Chintan V. 
Published: November 2024

Abstract
Aims/hypothesis
The aim of this study was to investigate racial and ethnic disparities in the use of sodium–glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor antagonists (GLP-1RAs) among older adults with type 2 diabetes and cardiorenal conditions.

Methods
Using Medicare fee-for-service data (2013–2019), this retrospective cohort study identified older adults (≥65 years) with type 2 diabetes initiating second-line therapies (SGLT2is, GLP1-RAs, dipeptidyl peptidase-4 inhibitors [DPP4is] and sulfonylureas [SUs]) with (1) heart failure (HF), (2) atherosclerotic cardiovascular disease (ASCVD), (3) chronic kidney disease (CKD) and (4) no recorded cardiorenal conditions. Participants were classified as non-Hispanic White, non-Hispanic Black and Hispanic. Multinomial regressions, adjusting for sociodemographic, clinical and county-level characteristics, were used to model the odds of initiating SGLT2is or GLP-1RAs within each cohort.

Results
Black participants with HF, ASCVD, CKD or no recorded cardiorenal conditions had 35% (adjusted OR 0.65 [95% CI 0.61, 0.68]), 33% (0.67 [0.64, 0.69]), 32% (0.68 [0.64, 0.72]) and 24% (0.76 [0.74, 0.79]) lower odds of initiating SGLT2is, respectively, than White participants. Disparities ameliorated from 50–60% lower odds in 2013 to 17–18% in 2019. Similar patterns were observed for GLP-1RA uptake among Black participants. By contrast, Hispanic participants had similar odds of SGLT2i initiation in the HF and CKD cohorts as White participants, but 6% (0.94 [0.91, 0.98]) lower odds in the ASCVD cohort. Notable disparities for Hispanic participants compared with White participants were observed for GLP-1RA uptake in the HF, ASCVD, CKD and no cardiorenal conditions cohorts: 11% (0.89 [0.84, 0.94]), 16% (0.84 [0.81, 0.87]), 16% (0.84 [0.80, 0.89]) and 25% (0.75 [0.72, 0.78]) lower odds, respectively. Participants had greater odds than White participants of initiating DPP4is, which confer no cardiorenal benefits, across all cohorts (HF 1.25 [1.19, 1.31]; ASCVD 1.36 [1.32, 1.40]; CKD 1.32 [1.26, 1.38). Adjustment for social determinants of health did not meaningfully change the study findings.

Conclusions/interpretation
Compared with White participants, disparities in the uptake of SGLT2is were evident for Black participants, and in the uptake of GLP-1RAs for both Black and Hispanic participants. This study highlights how type 2 diabetes management is evolving, while underscoring historical imbalances that have shown signs of abatement.

Graphical Abstract
From inbreeding to social behaviour: exploring female-biased sex allocation in the silk wasp Microstigmus rosae
Authors: Bonifacii Rosa Leena , Field Jeremy 
Published: November 2024

AbstractIn the Hymenoptera, female-biased sex ratios are often attributed to Local Mate Competition (LMC), which occurs when related males compete for access to the same mates, reducing fitness returns for male offspring relative to females. In social species, advantageous interactions between cooperating females can also promote female bias via Local Resource Enhancement (LRE). Despite recent theory suggesting potential interactions between these phenomena, studies of LMC in social species remain scarce. This study investigates female-biased sex ratio adjustment in the silk wasp Microstigmus rosae, a species exhibiting both incipient sociality and likely localised mating. Our analyses reveal several genetic indicators of local mating, including heterozygote deficiency and high inbreeding coefficients. Moreover, pairwise relatedness values between mothers and their inferred mates indicate that 35% of mating pairs were siblings or parent-offspring. In further support of the role of LMC, we find that our observed sex investment ratio of 0.35 is statistically equivalent to the theoretically expected evolutionary stable sex ratio, as predicted by partial LMC. We also find a clearly defined male-first sequential sex allocation strategy (M-F-F), a pattern typically attributed to extreme LMC. In contrast, we find no perceivable effect of cooperative behaviour (LRE) on the brood sex ratio. This rare demonstration of inbreeding and LMC in a social aculeate hymenopteran highlights the potential role of these factors in driving the evolution of social group formation in this species.
Individual representation in approval-based committee voting
Authors: Brill Markus , Israel Jonas , Micha Evi , Peters Jannik 
Published: November 2024

Abstract
When selecting multiple candidates based on approval preferences of voters, the proportional representation of voters’ opinions is an important and well-studied desideratum. Existing criteria for evaluating the representativeness of outcomes focus on groups of voters and demand that sufficiently large and cohesive groups are “represented” in the sense that candidates approved by some group members are selected. Crucially, these criteria say nothing about the representation of individual voters, even if these voters are members of groups that deserve representation. In this paper, we formalize the concept of individual representation (IR) and explore to which extent, and under which circumstances, it can be achieved. We show that checking whether an IR outcome exists is computationally intractable, and we verify that all common approval-based voting rules may fail to provide IR even in cases where this is possible. We then focus on domain restrictions and establish an interesting contrast between “voter interval” and “candidate interval” preferences. This contrast can also be observed in our experimental results, where we analyze the attainability of IR for realistic preference profiles.
Bioinformatic and experimental data pertaining to the role of the NLRP3 inflammasome in ovarian cancer
Authors: Ashmore Ayisha A. , Balasubramanian Brinda , Phillips Andrew , Asher Viren , Bali Anish , Ordóñez-Morán Paloma , Khan Raheela 
Published: November 2024

AbstractThe Nod-Like Receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome plays a role in regulating inflammatory signaling and is a well-established contributor to pyroptotic cell death. It has been investigated extensively in cancer but there remains limited evidence of its role within ovarian cancer (OC). Bioinformatic investigation of gene expression data has highlighted that higher expression of NLRP3 and genes associated with the NLRP3 complex appear to be positively correlated with OC and may also have prognostic significance. However, heterogeneity exists within the results and experimental data is limited and contradictory. If the NLRP3 inflammasome is to be exploited as a therapeutic target, further laboratory-based investigation is required to determine its role in cancer. Furthermore, its relationship with clinically important characteristics such as histopathological subtype may be of key significance in developing targeted therapies towards specific cohorts of patients.
Pollen season variations among anemophilous species in an Atlantic-influenced mediterranean environment: a long term study (1993–2022)
Authors: Montiel Nuria , Hidalgo Pablo J. , Adame José Antonio , González-Minero Francisco 
Published: November 2024

AbstractNumerous studies have shown that climate change is impacting the airborne pollen concentration of various anemophilous plant species, both herbaceous and woody. The aim of this study was to determine whether this trend, highly marked in Europe, is also occurring in the city of Huelva (south-western Spain), an area with a milder Mediterranean climate. The factors influencing the main pollen season were studied for all local taxa accounting for more than 1% of the total pollen collected, over the period 1993–2022, using a volumetric Hirst type trap to determine concentration. The study included a trend analysis of meteorological variables susceptible to climate change, specifically maximum, minimum and average temperature, precipitation and the number of hours of insolation per day. Although some of the variables analysed do not show significant trends for most taxa, such as start date or peak date, the overall results indicate a trend in the airborne pollen dynamics for herbaceous and woody taxa. Six of the eight woody taxa studied showed a significant trend towards increased pollen concentration, some of which are associated with temperature in previous seasons. In contrast, three of the five herbaceous taxa, which are more sensitive to short term meteorological variables, show a significant acceleration in the end date of the main pollen season, correlated negatively with temperature and insolation. In conclusion, some incipient changes are occurring, which may be indicative of future consequences on biodiversity in the Mediterranean area influenced by the Atlantic Ocean.
Exploring the relationships between ground observations and remotely sensed hazelnut spring phenology
Authors: Bajocco Sofia , Di Giulio Mara , Sallah Abdoul Hamid Mohamed , Bregaglio Simone 
Published: November 2024

Abstract
Crop phenology is very important in regular crop monitoring. Generally, phenology is monitored through field observation surveys or satellite data. The relationships between ground observations and remotely sensed derived phenological data can enable near-real-time monitoring over large areas, which has never been attempted on hazelnuts. In this study, we extracted phenological metrics derived from MODIS Enhanced Vegetation Index (EVI) in hazelnut production regions and compared them with the spring ground phenological data (BBCH scale) from orchards located in the same area of Turkey over the period from 2019 to 2022. We observed a specific temporal dynamic between remote sensing phenometrics and ground observations. The metrics Greenup, Upturning Date, and Threshold 20% metrics corresponded to the early of EVI growth and were synchronous with the female flowering of hazelnut and ending before bud break. The metrics Threshold 50% and Start of season were associated with the steepest portion of the EVI curve, i.e., canopy greening and thickening, and occurred between ovaries enlargement and leaves unfolding. The metrics Peak of Season, Stabilization Date, and Maturity corresponded to the end of spring vegetative growth. The main outcomes are that (i) female flowering occurred before 20% of vegetation development (BBCH 64P occurred about one month before Threshold 20%), (ii) phenometrics from satellite remote sensing (i.e., Upturning Date and Threshold 20%) well-reflected leaf emergence (rs = 0.30 and rs = 0.32, respectively; p < 0.05) and unfolding (rs = 0.35 and rs = 0.39, respectively; p < 0.05), and (iii) cluster appearance temporally aligned with the peak of the EVI curve (Stabilization Date and BBCH 71P differed by around 4 days). Our method is transferable to operational phenology monitoring, and future applications will consider the senescence season and the effect of environmental variability on the comprehension of vegetation dynamics.
Systematic assessment of early brain injury severity at admission with aneurysmal subarachnoid hemorrhage
Authors: Tuzi Sheri , Kranawetter Beate , Mielke Dorothee , Rohde Veit , Malinova Vesna 
Published: November 2024

AbstractEarly brain injury (EBI) after aneurysmal subarachnoid hemorrhage (aSAH) has been increasingly recognized as a risk factor for delayed cerebral ischemia (DCI). While several clinical and radiological EBI biomarkers have been identified, no tool for systematic assessment of EBI severity has been established so far. This study aimed to develop an EBI grading system based on clinical signs and neuroimaging for estimation of EBI severity at admission. This is a retrospective observational study assessing imaging parameters (intracranial blood amount, global cerebral edema (GCE)), and clinical signs (persistent loss of consciousness [LOC]) representative for EBI. The intracranial blood amount was semi-quantitatively assessed. One point was added for GCE and LOC, respectively. All points were summed up resulting in an EBI grading ranging from 1 to 5. The estimated EBI severity was correlated with progressive GCE requiring decompressive hemicraniectomy (DHC), DCI-associated infarction, and outcome according to the modified Rankin scale (mRS) at 3-month-follow up. A consecutive cohort including 324 aSAH-patients with a mean age of 55.9 years, was analyzed. The probability of developing progressive GCE was 9% for EBI grade 1, 28% for EBI grade 2, 43% for EBI grade 3, 61% for EBI grade 4, and 89% for EBI grade 5. The EBI grading correlated significantly with the need for DHC (r = 0.25, p < 0.0001), delayed infarction (r = 0.30, p < 0.0001), and outcome (r = 0.31, p < 0.0001). An EBI grading based on clinical and imaging parameters allowed an early systematic estimation of EBI severity with a higher EBI grade associated not only with a progressive GCE but also with DCI and poor outcome.
Communicating health risk in chronic kidney disease: a scoping review
Authors: Caton Emma , Aird Ros , Da Silva-Gane Maria , Sridharan Sivakumar , Wellsted David , Sharma Shivani , Farrington Ken 
Published: November 2024

Abstract
Background
Communicating risk is a key component of shared decision-making and is vital for the management of advanced chronic kidney disease (CKD). Despite this, there is little evidence to suggest how best to communicate health risk information to people living with CKD. The aim of this review was to identify and understand the nature of evidence-based risk communication strategies for people living with CKD.

Methods
We searched MEDLINE, CINAHL and Scopus databases for articles which described or evaluated the use of risk communication strategies within the renal population. Similar risk communication strategies were collated and summarised narratively.

Results
A total of 3700 sources were retrieved from the search, of which 19 were included in the review. Eleven studies reported primary research, and eight reported either narrative or systematic reviews. Seven main risk communication strategies were identified: framing, absolute versus relative risk, natural frequencies versus percentages, personalised risk estimates, qualitative risk communication, best-case/worst-case framework and use of graphs and graphics. There was a paucity of risk communication strategies specific to the CKD population.

Conclusion
Evidence-based strategies to improve health risk communication for patients living with CKD are lacking. There is a need to establish the informational and communication preferences for patients living with CKD to better understand how to best communicate health risk information to individuals in this population.

Graphical abstract
Cost effectiveness of difelikefalin for the treatment of patients with chronic kidney disease-associated pruritus undergoing hemodialysis in Italy
Authors: Manenti Lucio , Marcellusi Andrea , Di Brino Eugenio , Aiello Andrea , Barugolo Asia , Berto Patrizia , Soro Marco 
Published: November 2024

Abstract
Background
Chronic kidney disease (CKD)-associated pruritus is a condition that strongly impacts CKD patients and is associated with increased morbidity/mortality, and worse health-related quality of life (HRQoL). Difelikefalin is currently the only drug approved in Europe specifically for treating moderate to severe CKD-associated pruritus in patients undergoing hemodialysis. The KALM-1 and KALM-2 trials showed better efficacy of difelikefalin vs placebo and best supportive care. The aim of this study was to investigate the cost-effectiveness of difelikefalin according to the Italian National Health Service (NHS) perspective.

Methods
A cohort model represented by four health states (No, Mild, Moderate, and Severe pruritus) was adapted to the Italian setting. The model used data from the KALM-1 and -2 trials for efficacy, integrated with other publications for HRQoL estimations. To assess the cost of disease management, a recent Italian publication on CKD-associated pruritus was used and a price of €27 per difelikefalin vial was assumed. The base case analysis over a 15-year time horizon, and an additional 10-year scenario analysis, were established. Additionally, both deterministic univariate analysis and probabilistic multivariate sensitivity analyses were developed. Discount rates of 3% were applied. An acceptability threshold of 40,000 €/quality-adjusted life-year (QALY) was considered.

Results
The results show that difelikefalin plus best supportive care is cost-effective vs best supportive care alone, with an incremental cost-effectiveness ratio, in the base case, of €35,823/QALY. Both the scenario and sensitivity analyses confirmed the strength of the results.

Conclusions
Difelikefalin was found to be a cost-effective treatment for the Italian NHS. These results support its reimbursement and its inclusion in routine clinical practice.

Graphical abstract