bluuebunny/crossref_metadata_2025_split huggingface dataset:
iTRAQ-based comparative proteomics analysis reveals specific urinary biomarkers for various kidney diseases
Authors: Jin Juan , Gong Jianguang , Zhao Li , Li Yiwen , He Qiang 
Published: August 2019

Abstract
Background Urinary proteomics has been extensively applied to investigate renal diseases including acute kidney injury (AKI), chronic kidney disease (CKD), IgA nephropathy (IgAN) and diabetic CKD. However, differential urinary proteome studies have not been reported for multiple diseases. The present study was aimed to explore early clinical diagnosis biomarkers for patients with AKI, AKI+CKD, diabetic CKD, non-diabetic CKD with IgAN and non-diabetic CKD without IgAN. Methods Differentially expressed proteins (DEPs) were screened by iTRAQ labeling and 2-D LC-MS/MS. Bioinformatics analysis was performed by subsequent GO enrichment and KEGG pathway analysis. DEPs were authenticated by ELISA assay. Results 156, 156, 286, 187 and 184 differentially abundant proteins were identified in patients with AKI, AKI+CKD, diabetic CKD, and non-diabetic CKD with or without IgAN. Comparative analysis indicated that 34, 35 and 17 unique DEPs were found in AKI, AKI+CKD and CKD samples, respectively. 91 and 14 specific DEPs were screened out in diabetic CKD and non-diabetic CKD. In comparison with Non-diabetic CKD with IgAN (38 DEPs), 47 unique urinary proteins were found in Non-diabetic CKD without IgAN. Among these DEPs, urinary SAA1 and HGFAC were only unregulated in AKI and Non-diabetic CKD without IgAN implying that they might be employed as the potential indicators of the two diseases. C5, APOC1 and Reg3A upregulation was not exclusively expressed in each disease which suggested that they could not be used for biomarker to distinguish one disease from the other. Conclusion Collectively, this research contributes to the urinary biomarker discovery from multiple renal diseases.
Accuracy of Self-report for Cervical and Breast Cancer Screening: A Systematic Review and Meta-analysis
Authors: Anderson Johanna , Bourne Donald S. , Peterson Kim A. , Mackey Katherine M. 
Published: August 2019

Abstract
Background: Guideline-based breast and cervical cancer screenings are fundamental components of high-quality preventive women’s health care services. Accurate measurement of screening rates is vital to ensure all women are adequately screened. Our systematic review and meta-analysis aims to provide an updated synthesis of the evidence on the accuracy of self-reported measures of cervical and breast cancer screening compared to medical records.

Methods: To identify studies, we searched MEDLINE®, Cochrane Database of Systematic Reviews, and other sources up to July 2019. Two reviewers sequentially selected studies, abstracted data, and assessed internal validity and strength of the evidence. Adjusted summary numbers for sensitivity and specificity were calculated using a bivariate random-effects meta-analysis.

Results: Unscreened women tended to over-report screening among 39 included studies examining the accuracy of self-report for cervical and/or breast cancer screening. The specificity of self-report was 48% (95% CI 41 to 56) for cervical cancer screening and 61% (95% CI 53 to 69) for breast cancer screening while the sensitivity of self-report was much higher at 96% (95% CI 94 to 97) for cervical cancer screening and 96% (95% CI 95 to 98). We have moderate confidence in these findings, as they come from a large number of studies directly assessing the accuracy of self-report compared to medical records and are consistent with findings from a previous meta-analysis.

Conclusions: Unscreened women tend to over-report cervical and breast cancer screening, while screened women more accurately report their screening. Future research should focus on assessing the impact of over-reporting on clinical and system-level outcomes.
Ups and downs of drug rehab among women: a qualitative study
Authors: Boroumandfar Zahra , Kianpour Masoud , Afshari Maryam 
Published: August 2019

Abstract
Background: due to the increasing importance of addicted women and the need to pay particular attention to this vulnerable group, and more awareness of women-specific addiction prevention and rehab programs among authorities. Objectives: In this content analysis of qualitative study we explored experiences of the women’s experience of the ups and downs of drug rehab Methods: 30 participants (addicted women) were selected through purposive and theoretical sampling until data saturation. Data collection was conducted through semi structured interviews. Conventional content analysis was utilized to analyze the transcribed interviews. Results: Based on analysis of the obtained results, the experience of women from the ups and downs of leaving the drug abuse yielded two themes and nine sub-themes. The themes were “the need for emancipation” and “Sinking factors”. Conclusions: It is concluded that addiction rehab strategies can only lead the addicted women to a brighter life when, along with open-hearted assistance by the families, women-specific rehab centers are established to help them meet their specific needs.
The significance of resilience in mental health promotion of marriage immigrant women: A qualitative study of factors and processes
Authors: Jo Yeonjae 
Published: August 2019

Abstract
Background: This study explores a series of processes in which marriage immigrant women achieve positive mental health status after experiencing various marriage- and migrant-related difficulties through the framework of resilience theory. As marriage immigrant women face greater barriers to public health services than non-immigrant women, it is necessary to understand the related factors, process, and context to address these barriers and strengthen available assets. Methods: Using data from semi-structured interviews, the author applied theme analysis to identify factors that affect resilience and its development process. Results: Findings indicated that the process of resilience follows enduring difficulties, collapse of stability, access to professional help, satisfaction of desire, and experience of growth. A combination of the level of spousal support, children as a driving force for change, the need for economic activity, and satisfaction of desire were identified as factors affecting the difference in growth in marriage immigrant women’s resilience. Conclusions: Spouses, children, and economic activity play key roles in resilience in positive and negative ways. The existing information barrier should be addressed at a structural level to improve the mental health of marriage immigrant women, and the optimum time for intervention is suggested within two years post-migration. Efforts to build supportive relationships with Korean spouses and meet the needs of women’s desires may also help promote these women’s resilience.
Three-hour post-ERCP amylase level: a useful indicator for early prediction of PEP
Authors: Lv Ze-Hui , Kou Da-Qing , Guo Shi-Bin 
Published: August 2019

Abstract
Background : To evaluate the value of the 3-hour post-ERCP serum amylase level for early prediction of post-ERCP pancreatitis (PEP).
Method:
A study of 206 patients performed ERCP at a single centre was collected from 2011 to 2016. The serum amylase or lipase level was measured at 3 h after ERCP. The patients with PEP were recorded. ROC curves were used to statistically analyze the data: The enrolled patients were divided into two groups according to gender, then be analyzed respectively. We comprehensively evaluated the predictive value of PEP by serum amylase level 3-hour post-ERCP based on the results above.

Results : In the 206 patients, the 3-hour post-ERCP pancreatic amylase level was used as the test variable, and the PEP occurrence as the state variable to plot the ROC curve. The optimal cut-off value was 351U/L (sensitivity 76.19%, specificity 83.24%, positive likelihood ratio 4.55, negative likelihood ratio 0.29, Youden index 59.43%). There were 83 patients with both 3-hour post-ERCP amylase level and lipase level detected. The area under the ROC curve for the 3-hour post-ERCP serum amylase was 0.780, and the 95% confidence interval was 0.676-0.864. The optimal cut-off is 380U/L, and there was no statistically significant difference between the two for diagnostic accuracy. According to gender, there was no statistically significant difference in the diagnostic accuracy of the two groups. In the male group, 436 U/L serum amylase provided the greatest diagnostic accuracy with sensitivity(SE) of 70.5%, specificity(SP) of 89.2%, positive predictive value (PPV) 87.5%, and negative predictive value (NPV) 78.1%. Whereas, in the female group, 357U/L serum amylase provided the greatest diagnostic accuracy with sensitivity of 76.9%, specificity of 81.2%, positive predictive value of 80.4%, negative predictive value of 77.9%.

Conclusions: 1. The 3-hour post-ERCP serum amylase level is a useful measurement for predicting post-ERCP pancreatitis. 2. There was no significant difference between serum amylase and lipase 3-hour post-ERCP for predicting PEP. 3. There was no statistically significant difference between male and female using the 3-hour post-ERCP serum amylase level to prediction PEP . For female, the optimal cut-off value was 357 U/L, whereas male 436U/L .
Roles and Expectations of Male Partners from PMTCT services in Chiradzulu Malawi: A Qualitative Study
Authors: Kansinjiro Beatrice M'baya , Nyondo-Mipando Alinane Linda 
Published: August 2019

Abstract
Background: Prevention of mother to child transmission of HIV (PMTCT) is the main measure for curbing HIV infection in children. Male involvement (MI) greatly influences uptake and adherence to PMTCT services yet the level remain low in Sub Saharan Africa. Lack of well stipulated roles for men in PMTCT is one of the main barriers to MI. Studies on MI have focused on women and Health care workers (HCW), thereby making men silent partners. The main aim of the study was to explore the roles and expectations of male partners in PMTCT services in Malawi. Methods: This was a descriptive qualitative study that involved men whose partners were either pregnant or breastfeeding a child, health care workers working in PMTCT services for over six months and traditional leaders. We conducted 9 in-depth interviews and 12 key informant interviews from January to March 2018. All interviews were audio-recorded, transcribed and translated. Thematic analysis was employed to analyze data. Results: Male partners play supportive, HIV prevention behaviour change and decision-making roles in PMTCT services. Health assessment and health promotion activities are the male specific services required in PMTCT services and these should be delivered at both health facility and community levels. Conclusion : Male partners in PMTCT have expectations that need to be met at both health facility and community levels. There is need to have male-tailored package of health services that are directly provided to men along with PMTCT services at different levels in order to promote MI. The services should be provided in an atmosphere that allows and accepts male partners to exercise their roles in PMTCT services.
Efficiency of Iranian Hospitals before and after Health Sector Evolution Plan: A systematic Review and Meta-Analysis Study
Authors: Amini Saeed , Matin Behzad Karami , Anbari Zohreh , Nazari Javad , Salimi Yahya , Amiresmaili Mohammadreza , Karyani Ali Kazemi 
Published: August 2019

Abstract
Background Aging, chronic diseases, development of expensive and advanced technologies has increased hospitals costs which have necessitated their efficiency in utilization of resources. This systematic review and meta-analysis study has assessed the efficiency of Iran hospitals before and after 2011 Health Sector Evolution Plan (HSEP). Methods Internal and external databases were searched using specified keywords without considering time limitations. The retrieved articles were entered to EndNote considering inclusion and exclusion criteria and the final analysis was performed after removing duplicates. Heterogeneity between the studies was assessed using Q and I2 tests. Forest plot with 95% Confidence Interval (CI) used to calculate different types of efficiency. The data were analyzed using STATA 14. Results Random pooled estimation of hospitals technical, managerial and scale efficiencies were 0.84 (95%CI = 0.78, 0.52), 0.9 (95% CI= 0.85,0.94) and 0.88 (95%CI= 0.84, 0.91), respectively. Sub-group analysis on the basis of study year (before and after HSEP in 2011) indicated that random pool estimation of technical (0.86), managerial (0.91) and scale (0.90) efficiencies of Iran hospitals for 2011 and before were better than technical (0.78), managerial (0.86) and scale (0.74) efficiencies after 2011. Conclusion Type of hospitals’ ownership was effective on hospitals efficiency. However, HSEP has not improved hospitals efficiency, so that it is necessary to future national plans consider all aspects.
Serum Albumin and Activities of Daily Living in Chinese Centenarians: A Cross-Sectional Study
Authors: Han Ke , Wang Shengshu , Jia Wangping , Cao Wenzhe , Liu Miao , Yang Shanshan , Wang Jianhua , He Yao 
Published: August 2019

Abstract
Background Objective deterioration in activities of daily living (ADL) exists in older people, particularly grows with age. While as the criterion standard of positive aging and longevity, little information that focuses on centenarians is available. The objective of this study is to examine the relationship between serum albumin and activities of daily living among centenarians in long-lived areas.Methods design—population-based cross-sectional study; setting—a complete sample study in Hainan, the longest-lived areas of China; subjects—Chinese older adults aged 100 and above (N=1002); measurements—serum albumin, basic and instrumental activities of daily living (BADL and IADL).Results Of 1002 participants included in the analysis 287(28.64%) were BADL disability, and 648(64.67%) were IADL disability. The median serum albumin level was 38.5 g/L (interquartile range, 36.2-41.3). In multivariable analyses controlling for socio-demographic characteristics, lifestyle characteristics and other influential factors, low albumin in the bottom quartile were associated with BADL disability (OR=5.994;95% CI: 3.542-10.143) and IADL disability (OR=4.398; 95% CI, 2.661-7.269). Serum albumin concentration showed a significant inverse linear relationship with ADL disability (P for trend <0.001). In sex-stratified analyses, the association was more pronounced in women. And we found a nonlinear relationship between serum albumin and IADL disability in female centenarians (P=0.025) from restricted cubic splines.Conclusions Low levels of albumin were associated with the decline in ADL function in centenarians, and this association was gender-specific and more prominent in the female.
Immunosenescence profile and expression of the aging biomarker (p16INK4a) in testicular cancer survivors treated with chemotherapy.
Authors: Bourlon Maria Teresa , Velazquez Hugo E , Hinojosa Juan , Orozco Luis , Rios-Corzo Ricardo , Lima Guadalupe , Llorente Luis , Hernandez-Ramirez Diego F , Valentin-Cortez Francisco J , Medina-Rangel Irene , Atisha-Fregoso Yemil 
Published: August 2019

Abstract
Background Cytotoxic chemotherapy can cure advanced germ cell tumors. Nevertheless, cancer treatment may induce cellular senescence and accelerate molecular aging. The aging process implies an increase of cells expressing p16 INK4a and changes in lymphocyte subpopulations. Our aim was to study the potential induction of premature immunosenescence in testicular cancer survivors (TCS) exposed to chemotherapy. Patients and methods Case-control study of TCS treated with chemotherapy (≥3 BEP cycles, disease-free ≥3 months) compared with healthy controls. Peripheral blood mononuclear cells were isolated, and lymphocyte subpopulations were analyzed by flow cytometry. p16 INK4a expression in T cells was measured using qPCR. Percentage of lymphocyte subpopulations associated with immunosenescence and p16 INK4a expression in TCS compared to controls using the Wilcoxon signed-rank test. Results We included 16 cases and 16 controls. The median of age was 27 years (24-54) and median time on surveillance was 26.5 months (3-192). TCS had a lower percentage of total T cells and CD4+ T cells in total lymphocytes. Among the CD4+ T lymphocytes, TCS had a lower naïve CD4+ and an increased memory CD4+ cells. Within the CD8+ T lymphocytes, TCS exhibited a decrease in the percentage of naïve cells and an increase in CD8+CD45RA+CD57+ cells. TCS also exhibited a decreased memory CD19+ B cells compared to the controls. The relative expression of p16 INK4a in T cells was higher in TCS compared to the controls [1.33 (IQR 0.93-2.23): p=0.048). Conclusion TCS showed an increase in the expression of the aging biomarker p16 INK4a and a lymphocyte phenotype associated with immunosenescence; characterized by a decrease in naïve cells, and concomitant increment of memory cells. This phenomenon might contribute to the development of an immune risk profile, which is associated with an increased rate of infections and a diminished effect of vaccination in the elderly population. Further studies are warranted to define the clinical implications of this alteration in TCS.
The metastasis of the internal mammary lymph node-a neglected strategic high point of radiotherapy for breast cancer
Authors: Li Li , Zhang Hongyan , Wang Linwei , xie Conghua , Zhou Yunfeng , Zhong Yahua 
Published: August 2019

Abstract
Background : To investigate the metastatic rate of internal mammary lymph nodes (IMNs) and to provide recommendations on target volume delineation of IMNs for adjuvant radiotherapy of breast cancer patients. Methods : We retrospectively analyzed 114 breast cancer patients treated only by surgery without adjuvant radiotherapy who developed local and/or regional lymph node recurrence/metastasis in our institute from January 2015 to January 2019, and patients with widely lung or pleural metastases were excluded. We first analyzed the recurrence rate of the chest wall, the metastatic rate of internal mammary/anterior mediastinal, ipsilateral axillary and supraclavicular lymph nodes, and then investigated distribution of the IMNs. Results : Among all of these 114 patients, the recurrence rate of chest wall, the metastatic rate of IMNs, the IMNs/anterior mediastinal lymph nodes, the ipsilateral axillary lymph nodes, and the ipsilateral supraclavicular lymph nodes were 43%, 37.7%, 59.6%, 12.3% and 22.8%, respectively. The metastatic IMNs were mainly located from the first to the second intercostal space. However, metastatic lymph nodes could also be observed above the upper edge of the first rib. Conclusions : The metastatic rate is high in the IMNs and irradiation of the internal mammary lymphatic chain is indispensable. It is suggested that the upper bound of the internal mammary lymphatic chain should be up to the subclavian vein with 5 mm margin, thus connecting to the caudal border of supraclavicular CTV(Clinical Target Volume)in breast cancer patients with high risk of recurrence.
Predictive factors for the presence of invasive components in patients diagnosed with ductal carcinoma in situ based on preoperative biopsy
Authors: Lee Kwan Ho , Han Jung Woo , Kim Eun Young , Yun Ji Sup , Park Yong Lai , Park Chan Heun 
Published: August 2019

Abstract
Background

In patients diagnosed with ductal carcinoma in situ (DCIS) with needle biopsy before surgery, invasive component (IC) is often found in the postoperative tissue, which results in altered post-surgical care. However, there are no clinically available factors to predict IC, and few MRI studies are available for the detection of IC in DCIS patients.Methods

Patients with a DCIS diagnosis based on preoperative biopsy, who underwent breast surgery Kangbuk Samsung Hospital between Jan 2005 and June 2018, were retrospectively evaluated. Clinico-pathological and breast MRI factors were compared between DCIS and DCIS with IC in postsurgical specimens.Results

Of the 431 patients with a preoperative diagnosis of DCIS, 34 (7.9%) showed IC during the postoperative pathological investigations, and 217 (50.3%) underwent breast MRI. Among MRI-related factors, Mass-like enhancement on MRI was the sole but significant predictor of IC (HR=0.26, C.I.=0.07-0.93, p=0.038), while nipple-areolar complex invasion, enhancement peak and pattern were not statistically significant. Nuclear grade was the only significant predictor of IC in the analysis of other clinico-pathological factors (HR=2.39, C.I.=1.05-5.42, p=0.038 in univariate analysis, HR=2.86, C.I.=1.14-7.14, p=0.025 in multivariate analysis).Conclusions

Mass-like enhancement on MRI and high nuclear grade were associated with IC in patients with preoperative diagnosis of DCIS. Considering the high sensitivity of breast MRI for IC, further evaluation of the predictive value of MRI in preoperative DCIS patients is desirable.
PENGARUH PERBEDAAN AGAMA DAN ETNIS MASYARAKAT DALAM PELAKSANAAN PEKERJAAN SOSIAL
Authors: Syauqani Syauqani 
Published: August 2019

Religion has delivered multiple ways of life of different societies.Ethnically, religion develops distinguished identity that emerges fromsocial monopoly and internal tension of societies. Ethnic identity thancomes to the fore forming ethnic ways of life, thus every social behaviorreflects ethnic identity of a certain group. Thus, it is essential for socialworkers to develop social intervention within specific socialenvironment. Social workers begs to help individuals, social groups andsocieties to improve their social conditions and to create social conduciveenvironment for the society to empower themselves in order to reachtheir common goals.Keyword: Diversity, Religion, Ethnicity, Society and Social Work Masyarakat mempunyai kebutuhan â€“ kebutuhan tertentu untuk kelangsungan hidup, dan agama berfungsiÂ memenuhi sebagaian di anatara kebutuhan kebutuhan seperti interkasi sosial, kelas kehidupan, dan budaya. Setiap agama mengandung suatu ajaran moral yang menjadi pegangan bagi prilaku para penganutnya. Secara umum ajaran moral yang terkandung dalam suatu Agama dapat digolongkan menjadi kepentingnya menyangkut orang banyak yang bukan menyangkun seiman. Agama bisa dikatakan yang melahirkan berbagai macam entis atau cara kebiasaan masyarakat yang diidentikkan dengan kelompok â€“ kelompok memiliki corak krakteristik yang berbeda beda. identitas pembeda yang terjadi antara kelompok etnis yang dapat dilakukan melalui terpaan monopolitstik sosial dan internal kelompok etnis melalui keragaman bentuk etnis dari organisasi sosial. Untuk mempertegas tentang etnis dan relasi antaretnis yakni setiap tindakan sosial tidak luput dari tindakan yang bernuansa etnisitas. Pengertian etnis atau suku adalah suatu kesatuan sosial atau lingkungan masyarakat. pekerjaan sosial melakukan intervensi pada titik di mana orang berinteraksi dengan lingkungannya. pekerjaan sosial merupakan sebuah aktivitas profesional dalam menolong individu, kelompok, dan masyarakat dalam meningkatkan atau memperbaiki kapasitas mereka agar berfungsi sosial dan untuk menciptakan kondisi â€“ kondisi masyarakat yang kondusif dalam mencapai tujuan bersama. Kata kunci: Keberagaman, Agama, Etnis, Masyarakat, dan Pekerjaan Sosial