bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoarchitectonics of Biofunctionalized Metal–Organic Frameworks with Biological Macromolecules and Living Cells
Authors: Dutta Saikat , Kim Jeonghun , Hsieh Pin‐Hsun , Hsu Yu‐Shen , Kaneti Yusuf Valentino , Shieh Fa‐Kuen , Yamauchi Yusuke , Wu Kevin C.‐W. 
Published: July 2019

AbstractThe formation of biofunctionalized metal–organic frameworks (MOFs) by growing them on a variety of macromolecular biological species, particularly on enzymes and living cells, offers exciting opportunities for a wide range of applications, including biocatalysis, biosensing, and diagnoses. MOFs are commonly subjected to biofunctionalization and biomimetic mineralization, owing to their good chemical and thermal stabilities and easy preparation in aqueous medium under ambient conditions. The functionalization of MOFs with biological substances, such as enzymes, nonenzymatic proteins, and living cells promotes the formation of MOF‐based biocomposites which retain the biological functions of the embedded biological substances. The most common method to construct these biofunctionalized MOFs is either by directly growing the MOF on the biological moiety or by postsynthetic modification of the exterior surface of the MOF with the desired biological species. In particular, hierarchically porous MOFs (containing both mesopores and micropores) are ideal candidates for hosting enzymes and for the translocation of nonenzymatic proteins. This review covers various advanced strategies for developing MOF‐based biocomposites for a wide range of bioapplications, such as biomedical storage, tumor cell targeting, and drug delivery. The influence of MOFs on the biological activity of living cells and future prospects for developing novel MOF‐based biorefinery are discussed.
Rotation capacity of composite joints for slim‐floor beams
Authors: Duarte da Costa Job , Obiala Renata , Odenbreit Christoph 
Published: July 2019

AbstractThe analysis of a composite beam‐to‐column structure requires knowledge about, on the one hand, the behaviour of beams and columns and, on the other, the joints between such elements. For beam‐to‐column joints, for example, the lack of appropriate design rules forces structural engineers to model joints as pinned, despite the fact that a certain joint rigidity and bending resistance is available because of the upper reinforced concrete slab.
In this context, a research programme with experimental and numerical investigations was initiated at the University of Luxembourg [1]. This aim of this research was to identify the influence of two major joint components – the reinforced concrete slab and the steelwork connection – on the behaviour of composite joints under a hogging bending moment. Eight experimental tests were performed on beam‐to‐column joints. These tests were used to validate an FE model developed with the ABAQUS software, which allowed the simulation of further joint configurations without the need for additional laboratory tests.This article presents the results of experimental and numerical analyses. Good agreement was achieved between experimental tests and numerical simulations. The influence of the reinforcement and the steelwork connection on the structural properties of composite joints is derived and a new analytical method is proposed to determine the stiffnesses and rotation capacities of composite joints.
Experimentelle Untersuchungen an Slim‐Floor‐Trägern
Authors: Kuhlmann Ulrike , Lam Dennis , Zandonini Riccardo , Schorr Johannes , Sheehan Therese , Baldassino Nadia 
Published: July 2019

AbstractIn dem europäischen Forschungsprojekt SlimAPP „Slim‐Floor Beams – Preparation of application rules in view of improved safety, functionality and LCA” wurde ein umfassendes Versuchsprogramm zu Slim‐Floor‐Trägern durchgeführt, um ein tieferes Verständnis in das besondere Tragverhalten von Slim‐Floor‐Systemen zu bekommen. Das Versuchsprogramm umfasste Push‐out‐Versuche, Schubträgerversuche mit 4 m Länge, Biegeträgerversuche mit 6 m Länge und Biegeträgerversuche zur Bestimmung des Einflusses von Langzeiteffekten wie Kriechen und Schwinden. Durch die Wahl eines Basisquerschnitts und die Ausführung der verschiedenen Versuchsserien mit den gleichen Parametern und die Verwendung möglichst vergleichbarer Materialeigenschaften wurde eine Übertragbarkeit der Ergebnisse zwischen den Versuchskonfigurationen gewährleistet. Es werden die verschiedenen Versuchsserien, ihre Parameter und Ergebnisse im Einzelnen vorgestellt. Die Ergebnisse erlauben auch Schlussfolgerungen zum Tragverhalten von besonderen Verbunddübeln (CoSFB) und geben Erkenntnisse zum Trag‐ und Verformungsverhalten von Slim‐Floor‐Trägern gerade im Zusammenhang mit der Verdübelung. Ein solches Verständnis zum Tragverhalten von Slim‐Floor‐Trägern ist für eine gezielte effiziente und ökonomische Bemessung wichtig.
Entwicklung der Slim‐Floor‐Bauweise in Europa
Authors: Schäfer Markus , Braun Matthias 
Published: July 2019

AbstractFlachdecken in Verbundbauweise, auch Slim‐Floor‐ oder Shallow‐Floor‐Bauweise genannt, stellen innovative Deckensysteme für den Geschossbau dar. Dabei handelt es sich um gewalzte oder geschweißte Stahlprofile, die vollständig oder nahezu vollständig in die Decke integriert werden. Diese Bauweise repräsentiert eine der jüngsten Entwicklungen im Stahl‐Verbundbau und hat in den letzten beiden Jahrzehnten immer größere Bedeutung gewonnen. In diesem Beitrag werden die Bauweise und ihre Entwicklung vorgestellt.
Dreischeibenhaus Düsseldorf: der Stahlskelettbau ist eine Ikone der Moderne
Authors: Hauke Bernhard 
Published: July 2019

AbstractWer sich ein bisschen für Bauen und Architektur interessiert, kennt das Dreischeibenhaus in Düsseldorf als eine der stählernen Ikonen der Moderne. Aber über die architektonische Bedeutung hinaus hat das Hochhaus auch statisch‐konstruktiv einiges zu bieten. Die aufgehende Konstruktion einschließlich des Kerns ist ein nahezu reines Stahlskelett. Die Rohrstützen waren dem Bauherrn Phoenix‐Rheinrohr geschuldet. Die Deckenkonstruktion mit leichten Verbundträgern und 8 cm dünnen Betonplatten trägt maßgeblich zur herausragenden Leichtigkeit der Gesamtkonstruktion bei. Inzwischen ist das Dreischeibenhaus liebevoll modernisiert. Interessantester Punkt ist hierbei die Fassade, welche das historische Erscheinungsbild bewahrt, aber technisch auf der Höhe der Zeit ist.
Tunneling nanotubes mediate the expression of senescence markers in mesenchymal stem/stromal cell spheroids
Authors: Whitehead Jacklyn , Zhang Jiali , Harvestine Jenna N. , Kothambawala Alefia , Liu Gang-yu , Leach J. Kent 
Published: July 2019

Abstract
The therapeutic potential of mesenchymal stem/stromal cells (MSCs) is limited by acquired senescence following prolonged culture expansion and high-passage numbers. However, the degree of cell senescence is dynamic, and cell-cell communication is critical to promote cell survival. MSC spheroids exhibit improved viability compared with monodispersed cells, and actin-rich tunneling nanotubes (TNTs) may mediate cell survival and other functions through the exchange of cytoplasmic components. Building upon our previous demonstration of TNTs bridging MSCs within these cell aggregates, we hypothesized that TNTs would influence the expression of senescence markers in MSC spheroids. We confirmed the existence of functional TNTs in MSC spheroids formed from low-passage, high-passage, and mixtures of low- and high-passage cells using scanning electron microscopy, confocal microscopy, and flow cytometry. The contribution of TNTs toward the expression of senescence markers was investigated by blocking TNT formation with cytochalasin D (CytoD), an inhibitor of actin polymerization. CytoD-treated spheroids exhibited decreases in cytosol transfer. Compared with spheroids formed solely of high-passage MSCs, the addition of low-passage MSCs reduced p16 expression, a known genetic marker of senescence. We observed a significant increase in p16 expression in high-passage cells when TNT formation was inhibited, establishing the importance of TNTs in MSC spheroids. These data confirm the restorative role of TNTs within MSC spheroids formed with low- and high-passage cells and represent an exciting approach to use higher-passage cells in cell-based therapies.
DNA‐Templated Copper Nanoprobes: Overview, Feature, Application, and Current Development in Detection Technologies
Authors: Chen Chung‐An , Chen Shih‐Chia , Shiddiky Muhammad J. A. , Chen Chien‐Fu , Wu Kevin C.‐W. 
Published: July 2019

AbstractMetal nanoprobes have recently attracted board research interestinr their application in establishing sensing systems due to their unique optical, electrical, physical, and chemical properties. In comparison to gold and silver nanoprobes, analytical platform based on copper nanoprobes (Cu‐NPs) is still in the early stages of development. In this review, we focus on single‐stranded, and double‐stranded DNA capped Cu‐NPs sensing systems which have been designed for various analytes, including metal ions, anions, small molecules, biomolecules (DNA, RNA, and protein, etc.). In addition, the application of Cu‐NPs in biological labeling or bio‐imaging platforms has also been introduced and summarized.
Progesterone affects sex differentiation and alters transcriptional of genes along circadian rhythm signaling and hypothalamic‐pituitary‐gonadal axes in juvenile Yellow River Carp (Cyprinus carpio var.)
Authors: Xia Xiaohua , Wang Peijin , Wan Ruyan , Chang Zhongjie , Du Qiyan 
Published: July 2019

AbstractProgesterone (P4) is a biologically active steroid hormone that is involved in the regulation of oocyte growth and maturation, as well as development of the endometrium and implantation in the uterus of humans. It can also stimulate oocyte maturation in female fish, as well as spermatogenesis and sperm motility in male fish. Thus, P4 has been extensively used in human and animal husbandry as a typical progestin. However, P4 remaining in the water environment will pose a potential hazard to aquatic organisms. For example, it can interfere with sex differentiation and reproduction in aquatic vertebrates such as fish. Therefore, we investigated the effects of prolonged progesterone exposure on the expression of genes related to circadian rhythm signaling and the hypothalamic‐pituitary‐gonadal (HPG) axes in Yellow River Carp, which may have a potential impact on their sex differentiation. Our results suggested that P4 exposure altered the expression of genes related to circadian rhythm signaling, which can lead to disorders in the endocrine system and regulate the HPG axes‐related activities. Furthermore, the expression of genes related to the HPG axes was also altered, which might affect gonadal development and the reproductive systems of Yellow River Carp. In addition, these changes may provide a plausible mechanism for the observed shifts in their sex ratio toward females.
Work engagement and task performance within a global Dutch ICT-consulting firm: The mediating role of innovative work behaviors
Authors: van Zyl Llewellyn Ellardus , van Oort Amber , Rispens Sonja , Olckers Chantal 
Published: July 2019

AbstractThe information and communication technology (ICT) sector within the Netherlands is a major driver of globalization, the country’s economic growth and innovation. The Dutch ICT sector’s performance is increasingly becoming dependent upon employee driven innovations in order to address the needs of the sectors they service. In other words, the ICT sector within the Netherlands is largely dependent upon the performance and innovative capacity of its employees; both of which are functions of employee engagement. Given the high demand, and low supply of talent within this sector, ICT organizations need to develop innovative ways to enhance the performance capacities of its people. Developing an engaged and highly innovative workforce seems to be an efficient way to activate employees’ performance. As such, the aim of this paper was to investigate the mediating function of employee driven innovative work behaviors in the relationship between work engagement and task performance within the a Dutch ICT consulting firm. A cross-sectional survey-based research design, employing a census-based sampling method, was employed to obtain data from a global ICT consulting firm within the Netherlands (n = 232). The Utrecht Work Engagement Scale, the Innovative Work Behavior Scale and the Task Performance Scale was used to assess the associative subjective experiences of ICT employees. The results showed that work engagement is a significant driver for innovative work behaviors, which in turn affects the task performance of employees. Further, innovative work behaviors are therefore important to translate the engaging energies of employees into performance. This paper discusses the theoretical and practical implications of these findings.
Parental licensing: an Australian perspective
Authors: Ainsworth Frank 
Published: July 2019

AbstractParental licensing is the idea that parenting competence should be demonstrated prior to adults achieving full parental rights. It is a long-standing idea that is alive among a host of academic philosophers, political scientists and others interested in children’s rights. The question is – is the notion of parental licensing a good idea or is it an extreme authoritarian response to the social problem of child abuse and neglect? The next question is – if parental licensing was in place, who would decide on parental competence, what are the boundaries of competence and how would competence be measured? And what about those adults who are deemed as incompetent? It is worth considering the proposition that, by endorsing the concept of the “best interests of the child” and passing legislation that gives standing to the removal of a child from parental care, by default this constitutes a system of parental licensing.
Decaying turbulence in a stratified fluid of high Prandtl number
Authors: Okino Shinya , Hanazaki Hideshi 
Published: July 2019

Decaying turbulence in a density-stratified fluid with a Prandtl number up to $Pr=70$ is investigated by direct numerical simulation. In turbulent flow with a Prandtl number larger than unity, it is well known that the passive scalar fluctuations cascade to scales smaller than the Kolmogorov scale, and show the $k^{-1}$ spectrum in the viscous–convective range, down to the Batchelor scale. In decaying stratified turbulence, the same phenomenon is initially observed for the buoyant scalar of high $Pr~(=70)$, until the Ozmidov scale becomes small and the buoyancy becomes effective even at the Kolmogorov scale. After that moment, however, the velocity components near the Kolmogorov scale begin to show strong anisotropy dominated by the vertically sheared horizontal flow, which reduces the vertical scale of density fluctuations. An analysis similar to that of Batchelor (J. Fluid Mech., vol. 5, 1959, pp. 113–133) indeed shows that the vertically sheared horizontal flow reduces the vertical scale of density fluctuations, without changing the horizontal scale.
Swimming mediated by ciliary beating: comparison with a squirmer model
Authors: Ito Hiroaki , Omori Toshihiro , Ishikawa Takuji 
Published: July 2019

The squirmer model of Lighthill and Blake has been widely used to analyse swimming ciliates. However, real ciliates are covered by hair-like organelles, called cilia; the differences between the squirmer model and real ciliates remain unclear. Here, we developed a ciliate model incorporating the distinct ciliary apparatus, and analysed motion using a boundary element–slender-body coupling method. This methodology allows us to accurately calculate hydrodynamic interactions between cilia and the cell body under free-swimming conditions. Results showed that an antiplectic metachronal wave was optimal in the swimming speed with various cell-body aspect ratios, which is consistent with former theoretical studies. Exploiting oblique wave propagation, we reproduced a helical trajectory, likeParamecium, although the cell body was spherical. We confirmed that the swimming velocity of model ciliates was well represented by the squirmer model. However, squirmer modelling outside the envelope failed to estimate the energy costs of swimming; over 90 % of energy was dissipated inside the ciliary envelope. The optimal swimming efficiency was given by the antiplectic wave; the value was 6.7 times larger than in-phase beating. Our findings provide a fundamental basis for modelling swimming micro-organisms.
Preservation of the mean residual life order for coherent and mixed systems
Authors: Lindqvist Bo H. , Samaniego Francisco J. , Wang Nana 
Published: July 2019

AbstractThe signature of a coherent system has been studied extensively in the recent literature. Signatures are particularly useful in the comparison of coherent or mixed systems under a variety of stochastic orderings. Also, certain signature-based closure and preservation theorems have been established. For example, it is now well known that certain stochastic orderings are preserved from signatures to system lifetimes when components have independent and identical distributions. This applies to the likelihood ratio order, the hazard rate order, and the stochastic order. The point of departure of the present paper is the question of whether or not a similar preservation result will hold for the mean residual life order. A counterexample is provided which shows that the answer is negative. Classes of distributions for the component lifetimes for which the latter implication holds are then derived. Connections to the theory of order statistics are also considered.
Central limit theorem for mean and variogram estimators in Lévy–based models
Authors: Rønn-Nielsen Anders , Vedel Jensen Eva B. 
Published: July 2019

AbstractWe consider an infinitely divisible random field in ℝd given as an integral of a kernel function with respect to a Lévy basis. Under mild regularity conditions, we derive central limit theorems for the moment estimators of the mean and the variogram of the field.
Cramér type moderate deviations for random fields
Authors: Beknazaryan Aleksandr , Sang Hailin , Xiao Yimin 
Published: July 2019

AbstractWe study the Cramér type moderate deviation for partial sums of random fields by applying the conjugate method. The results are applicable to the partial sums of linear random fields with short or long memory and to nonparametric regression with random field errors.
On the multifractal analysis of the covering number on the Galton–Watson tree
Authors: Attia Najmeddine 
Published: July 2019

AbstractWe consider, for t in the boundary of a Galton–Watson tree $(\partial \textsf{T})$, the covering number $(\textsf{N}_n(t))$ by the generation-n cylinder. For a suitable set I and sequence (sn), we almost surely establish the Hausdorff dimension of the set $\{ t \in \partial {\textsf{T}}:{{\textsf{N}}_n}(t) - nb \ {\sim} \ {s_n}\} $ for b ∈ I.
A spatio-temporal point process model for particle growth
Authors: Hössjer Ola 
Published: July 2019

AbstractA spatio-temporal model of particle or star growth is defined, whereby new unit masses arrive sequentially in discrete time. These unit masses are referred to as candidate stars, which tend to arrive in mass-dense regions and then either form a new star or are absorbed by some neighbouring star of high mass. We analyse the system as time increases, and derive the asymptotic growth rate of the number of stars as well as the size of a randomly chosen star. We also prove that the size-biased mass distribution converges to a Poisson–Dirichlet distribution. This is achieved by embedding our model into a continuous-time Markov process, so that new stars arrive according to a marked Poisson process, with locations as marks, whereas existing stars grow as independent Yule processes. Our approach can be interpreted as a Hoppe-type urn scheme with a spatial structure. We discuss its relevance for and connection to models of population genetics, particle aggregation, image segmentation, epidemic spread, and random graphs with preferential attachment.
Random affine simplexes
Authors: Götze Friedrich , Gusakova Anna , Zaporozhets Dmitry 
Published: July 2019

AbstractFor a fixed k ∈ {1, …, d}, consider arbitrary random vectors X0, …, Xk ∈ ℝd such that the (k + 1)-tuples (UX0, …, UXk) have the same distribution for any rotation U. Let A be any nonsingular d × d matrix. We show that the k-dimensional volume of the convex hull of affinely transformed Xi satisfies \[|{\rm{conv}}(A{X_{\rm{0}}} \ldots ,A{X_k}){\rm{|}}\mathop {\rm{ = }}\limits^{\rm{D}} (|{P_\xi }\varepsilon |/{\kappa _k})|{\rm{conv}}\left( {{X_0}, \ldots ,{X_k}} \right)\]
, where ɛ:= {x ∈ ℝd : x┬ (A┬ A)−1x ≤ 1} is an ellipsoid, Pξ denotes the orthogonal projection to a uniformly chosen random k-dimensional linear subspace ξ independent of X0, …, Xk, and κk is the volume of the unit k-dimensional ball. As an application, we derive the following integral geometry formula for ellipsoids: ck,d,p ∫Ad,k |ɛ ∩ E|p+d+1 μd,k(dE) = |ɛ|k+1 ∫Gd,k |PLɛ|pνd,k(dL), where $c_{k,d,p} = \big({\kappa_{d}^{k+1}}/{\kappa_k^{d+1}}\big) ({\kappa_{k(d+p)+k}}/{\kappa_{k(d+p)+d}})$
. Here p &gt; −1 and Ad,k and Gd,k are the affine and the linear Grassmannians equipped with their respective Haar measures. The p = 0 case reduces to an affine version of the integral formula of Furstenberg and Tzkoni (1971).
Exact simulation of generalised Vervaat perpetuities
Authors: Dassios Angelos , Qu Yan , Lim Jia Wei 
Published: July 2019

AbstractWe consider a generalised Vervaat perpetuity of the form X = Y1W1 +Y2W1W2 + · · ·, where $W_i \sim {\cal U}^{1/t}$ and (Yi)i≥0 is an independent and identically distributed sequence of random variables independent from (Wi)i≥0. Based on a distributional decomposition technique, we propose a novel method for exactly simulating the generalised Vervaat perpetuity. The general framework relies on the exact simulation of the truncated gamma process, which we develop using a marked renewal representation for its paths. Furthermore, a special case arises when Yi = 1, and X has the generalised Dickman distribution, for which we present an exact simulation algorithm using the marked renewal approach. In particular, this new algorithm is much faster than existing algorithms illustrated in Chi (2012), Cloud and Huber (2017), Devroye and Fawzi (2010), and Fill and Huber (2010), as well as being applicable to the general payments case. Examples and numerical analysis are provided to demonstrate the accuracy and effectiveness of our method.
Absolute regularity of semi-contractive GARCH-type processes
Authors: Doukhan Paul , Neumann Michael H. 
Published: July 2019

AbstractWe prove existence and uniqueness of a stationary distribution and absolute regularity for nonlinear GARCH and INGARCH models of order (p, q). In contrast to previous work we impose, besides a geometric drift condition, only a semi-contractive condition which allows us to include models which would be ruled out by a fully contractive condition. This results in a subgeometric rather than the more usual geometric decay rate of the mixing coefficients. The proofs are heavily based on a coupling of two versions of the processes.