bluuebunny/crossref_metadata_2025_split huggingface dataset:
Most effective pain‐control procedure for open liver surgery: a network meta‐analysis
Authors: Zhou Ling , Huang Jian , Chen Changwang 
Published: March 2018

BackgroundTo determine the most effective pain‐control procedure for open liver surgery through a network meta‐analysis and provide a best developing direction in this field.MethodsPubMed, Embase and Cochrane Library database were searched for randomized controlled trials up to 1 July 2016. We extracted data on post‐operative pain score at the 4th–8th hour and 24th hour from studies that compared various pain‐control strategies. Network meta‐analysis was conducted in Aggregate Data Drug Information System software by evaluating the parametric pain score at rest and on movement. Cumulative probability value was utilized to rank the procedures under examination. The inconsistency would also be tested by node‐splitting models.ResultsTwelve articles containing 661 patients were included. Intrathecal analgesia plus intravenous analgesia played the most effective role in pain controlling at post‐operative 4–8 h (both at rest and on movement, P = 0.49 and P = 0.62, respectively) and at post‐operative 24 h (both at rest and on movement, P = 0.46 and P = 0.29, respectively). Node‐splitting models test revealed that no significant inconsistency existed in this research.ConclusionsIntrathecal analgesia plus intravenous analgesia revealed the most effective clinical pain‐control value for open liver surgery. More importantly, we believed that creating a better comprehensive and systematic combined pain‐control procedure should be considered as the developing direction in this field.
Clinical significance of serum transthyretin level in patients with hepatocellular carcinoma
Authors: Shimura Tatsuo , Shibata Masahiko , Kofunato Yasuhide , Okada Ryo , Ishigame Teruhide , Kimura Takashi , Kenjo Akira , Marubashi Shigeru 
Published: March 2018

BackgroundAlthough serum albumin has been reported to be useful as a prognostic biomarker for various malignancies, it is not suitable for prognosis of patients with hepatocellular carcinoma (HCC) due to impaired liver function. We aimed to determine whether serum transthyretin (TTR) level can be used as a novel prognostic biomarker.MethodsSerum levels of TTR, as well as other nutritional and inflammatory parameters including angiogenic factors, were examined in 25 patients with HCC.ResultsThe serum TTR levels exhibited a statistically significant inverse correlation with interleukin‐6 (r = −0.412, P = 0.041), and showed statistically significant correlations with retinol‐binding protein (r = 0.919, P < 0.001) and albumin (r = 0.442, P = 0.027). The patients with TTR <11.4 mg/dL (P = 0.012), those with ≥T2 (P = 0.011) and those with a retention rate of indocyanine green after 15 min ≥15.5 (P = 0.037) showed poorer prognoses than the counterparts of each parameter. The TTR level <11.4 mg/dL (hazard ratio: 4.837, 95% confidence interval: 1.118–20.926, P = 0.035) and ≥T2 (hazard ratio: 5.011, 95% confidence interval: 1.243–20.203, P = 0.023) were independent prognostic factors of HCC patients.ConclusionSerum TTR measurement can be useful for predicting the prognosis of patients with HCC.
Formation of Blood Foam in the Air Trap During Hemodialysis Due to Insufficient Automatic Priming of Dialyzers
Authors: Jonsson Per , Lindmark Lorentz , Axelsson Jan , Karlsson Lars , Lundberg Lennart , Stegmayr Bernd 
Published: March 2018

AbstractWe were encouraged to investigate the reasons for large amounts of foam observed in bloodlines during hemodialysis (HD). Foam was visible in the venous air trap within the Artis Gambro dialysis device. Estimates of the extent of foam were graded (0—no foam, 10—extensive foam) by two persons that were blind to the type of dialyzer used. Thirty‐seven patients were involved in the dialysis procedures. Consecutive dialyses were graded using dialyzers from Fresenius Medical Care (CorDiax dialyzers that were used for high flux HD—FX80 and FX100, and for hemodiafiltration—FX1000). The extracorporeal circuit was primed automatically by dialysate using Gambro Artis software 8.15 006 (Gambro, Dasco, Medolla Italy, Baxter, Chicago, IL, USA). The priming volume recommended by the manufacturer was 1100 mL, whereas our center uses 1500 mL. Extensive amounts of blood foam were visual in the air traps. Although the manufacturer recommended extension of priming volume up to 3000 mL, this did not eliminate the foam. Microbubble measurement during HD revealed the air to derive from the dialyzers. When changing to PF210H dialyzers (Baxter) and using a priming volume of 1500 mL, the foam was significantly less (P < 0.01). The extent of foam correlated with the size of the FX‐dialyzer surface (P = 0.002). The auto‐priming program was updated to version 8.21 by the manufacturer and the extent of foam in the air trap using FX dialyzers was now reduced and there was no longer a difference between FX and PF dialyzers, although less foam was still visible in the venous air trap during several dialyses. In conclusion, this study urgently calls attention to blood foam development in the venous air trap when using Artis devices and priming software 8.15 in combination with Fresenius dialyzers. Updated auto‐priming software (version 8.21) of Artis should be requested to reduce the extent of foam for the Fresenius dialyzers. Other interactions may also be present. We recommend further studies to clarify these problems. Meanwhile caution is warranted for the combined use of dialysis devices and dialyzers with incompatible automatic priming.
Cosmetic results of enucleation and/or external beam radiation therapy in 195 retinoblastoma survivors
Authors: Mourits Daphne L. , Hartong Dyonne T. , Lissenberg‐Witte Birgit I. , Bosscha Machteld I. , Tan H. Stevie , Moll Annette C. 
Published: March 2018

AbstractPurposeTo report the cosmetic outcome and late effects of enucleation and/or irradiation for retinoblastoma and to evaluate the role of orbital implants.MethodsPatients (age >4 years) enucleated and/or irradiated for retinoblastoma, visiting the hospital for routine follow‐up (April 2013 to May 2015), were included in our cross‐sectional study. Data were obtained via clinical records, questionnaires, physical measurements and standardized photographs. Two independent observers scored the cosmetic features: upper eyelid position, lower eyelid position, volume deficiency, and prosthesis motility and overall cosmetic appearance.ResultsA total of 195 patients participated. Ptosis was seen in 45 (28.3%) patients, lower lid sagging in 45 (28.3%). Both complications were associated with the orbital implant; ptosis being more common with increasing implant size (5.6% without implant, 16.7% with small implant, 37.1% with medium implant and 76.9% with large implant) and lower lid sagging being more common in patients without implant (20% with implant versus 37.5% without). Volume loss of the superior sulcus was seen in 107 sockets (66.9%), most frequent in additionally irradiated patients (χ2(2) = 42.7, p < 0.001) and in patients without implant (χ2(2) = 11.92, p = 0.003). Prosthesis motility was better in patients with orbital implant, regardless of the size.ConclusionMinor late and potentially treatable effects were seen in patients with implant. Larger sized implants were associated with a higher incidence of ptosis; implant size did not affect subjective outcome with respect to volume or prosthetic motility. Treatment with EBRT had a less favourable outcome.
Utility of preoperative 3‐D simulation of laparoscopic lateral pelvic lymph node dissection for advanced rectal cancer: Surgical outcomes of 10 initial cases
Authors: Horie Hisanaga , Koinuma Koji , Ito Homare , Sadatomo Ai , Naoi Daishi , Kono Yoshihiko , Inoue Yoshiyuki , Morimoto Mitsuaki , Tahara Makiko , Lefor Alan K , Sata Naohiro , Sasaki Takahiro , Sugimoto Hideharu 
Published: March 2018

AbstractIntroductionLaparoscopic lateral pelvic lymph node dissection (LPLD) is technically challenging because of the complicated anatomy of the pelvic wall. To overcome this difficulty, we introduced preoperative 3‐D simulation. The aim of the study is to investigate the usefulness of preoperative 3‐D simulation for the safe conduct of laparoscopic LPLD for rectal cancer.MethodsAfter undergoing colonoscopy, patients were brought to the radiology suite where multi‐detector row CT was performed. Three‐dimensional images were constructed at a workstation and showed branches of the iliac artery and vein, ureter, urinary bladder, and enlarged lymph nodes. All members of the surgical team participated in preoperative simulation using the 3‐D images.ResultsA total of 10 patients with advanced lower rectal cancer and enlarged lateral pelvic lymph nodes underwent laparoscopic unilateral LPLD after total mesorectal excision, tumor‐specific mesorectal excision, or total proctocolectomy. Four of the 10 patients (40%) had variations in pelvic vascular anatomy. The median operative time for unilateral LPLD was 91 min (range, 66–142 min) and gradually declined, suggesting a good learning curve. The median number of lateral pelvic lymph nodes harvested was nine (range, 3–16). The median estimated blood loss was 13 mL (range, 10–160 mL). No conversion to open surgery or intraoperative complications occurred. No patient had major postoperative complications.ConclusionPreoperative 3‐D simulation may be useful for the safe conduct of laparoscopic LPLD, especially for surgeons with limited prior experience.
Preservice teachers' conceptions of teaching using mobile devices and the quality of technology integration in lesson plans
Authors: Tsai Pei‐Shan , Tsai Chin‐Chung 
Published: March 2018

AbstractThis study explored the relationships among preservice teachers' conceptions of teaching using mobile devices and the quality of technology integration in lesson plans. A total of 47 preservice teachers in Taiwan who had experienced designing their own lesson plans and teaching materials (ie, eBooks and applications) for teaching using mobile devices (ie, smart phones and tablet PCs) participated in this study. The results showed that four qualitatively different conceptions of teaching using mobile devices were identified, namely “technology support,” “knowledge transmission,” “learning facilitation,” and “supporting students to learn.” This study also found that the teachers who had more constructivist perceptions of teaching using mobile devices, such as facilitating students' understanding in a convenient way or supporting student learning in a more active way, appeared to attain better quality technology integration in their lesson plans than those teachers with traditional conceptions.
Impact of novel therapies for mantle cell lymphoma in the real world setting: a report from the UK's Haematological Malignancy Research Network (HMRN)
Authors: Smith Alexandra , Roman Eve , Appleton Simon , Howell Debra , Johnson Rod , Burton Cathy , Patmore Russell 
Published: March 2018

SummaryThe treatment landscape for mantle cell lymphoma (MCL) has changed dramatically in recent years, with findings from clinical trials reporting improvements in survival. Data on the general patient population are, however, sparse; and it is unclear whether the effects observed in clinical trials have translated into the real‐world setting. To investigate this, we examined first‐line and relapsed/refractory (RR) disease management in 335 MCL patients diagnosed between 2004 and 2015 in an established population‐based patient cohort, along with data on demographic, diagnostic and prognostic factors. Marked treatment and survival changes were observed; first‐line rituximab immunotherapy, for example, increased from 32% to 86% over the 11‐year period, and median survival increased from 2·0 years among those first treated in 2004–2011 to 3·5 years among those treated in 2012–2015. Outcomes for RR disease also improved, from 8 months in 2004–2011 to 16·8 months in 2012–2015, coinciding with the introduction of agents, such as bendamustine and ibrutinib. Encouragingly, improvements were seen across all ages; 1‐year overall survival among patients over 70 years treated for RR disease almost doubled. Our analyses underscore the importance of monitoring the impact of treatment changes in the real‐world setting.
Antibiotic susceptibility of intestinal Escherichia coli in men undergoing transrectal prostate biopsies: a prospective, registered, multicentre study
Authors: Knaapila Juha , Kallio Heini , Hakanen Antti J , Syvänen Kari , Ettala Otto , Kähkönen Esa , Lamminen Tarja , Seppänen Marjo , Jambor Ivan , Rannikko Antti , Riikonen Jarno , Munukka Eveliina , Eerola Erkki , Gunell Marianne , Boström Peter J. 
Published: March 2018

ObjectivesTo determine, in a prospective, multicentre setting, the prevalence of fluoroquinolone‐resistant (FQ‐R) and extended‐spectrum β‐lactamase (ESBL)‐producing Escherichia coli (E. coli) strains in men undergoing transrectal ultrasonography‐guided prostate biopsy (TRUS‐Bx) in Finland; and to survey the associated risk factors for having the previously mentioned strains.Patients and MethodsThis is a substudy of the trial investigating the role of magnetic resonance imaging (MRI) in prostate cancer diagnosis (Improved Prostate Cancer Diagnosis – Combination of Magnetic Resonance Imaging Targeted Biopsies and Biomarkers Multi‐institutional Study [multi‐IMPROD], NCT02241122). In all, 359 patients from four study centres were recruited to this prospective study. After having signed the informed consent form, these men with suspicion of prostate cancer completed a detailed questionnaire on their medical, smoking, and travelling history, as well as their recent use of antibiotics. After the bi‐parametric MRI scan, TRUS‐Bx was taken and a rectal swab sample was collected and cultured for determining the antimicrobial susceptibility profile of E. coli strains. The potential risk factors for having FQ‐R or third‐generation cephalosporin‐resistant (3GC‐R) E. coli strains were analysed using univariate and multivariate logistic regression analysis.ResultsThe percentage of FQ‐R and 3GC‐R E. coli strains amongst the study population was 13% and 8%, respectively. Amongst patients having E. coli strains, the rate of FQ‐R and 3GC‐R strains was 14% and 8%, respectively. Of the 3GC‐R E. coli strains, 62% proved to be ESBL‐producers and 88% were also FQ‐R. In multivariate analysis, international travel during the preceding year significantly increased the risk of having a FQ‐R E. coli strain (odds ratio [OR] 3.592, P = 0.001) and, unexpectedly, use of antibiotics during the previous year significantly decreased this risk (OR 0.442, P = 0.035). No significant risk factors for having 3GC‐R E. coli were identified.ConclusionThe occurrence of intestinal FQ‐R and/or 3GC‐R (potentially ESBL‐producing) E. coli strains in men undergoing TRUS‐Bx in Finland is notable. The finding is consistent with the global increase in antimicrobial resistance. International travel appears to be an indisputable risk factor for having intestinal FQ‐R E. coli strains. The contemporary antimicrobial resistance situation should be taken into account in the care of post‐TRUS‐Bx infections.
Expression of tumour progression‐associated genes in circulating tumour cells of patients at different stages of prostate cancer
Authors: Russo Giorgio I. , Bier Simone , Hennenlotter Jörg , Beger Gunthild , Pavlenco Lucretia , van de Flierdt Jens , Hauch Siegfried , Maas Moritz , Walz Simon , Rausch Steffen , Bedke Jens , Morgia Giuseppe , Stenzl Arnulf , Todenhöfer Tilman 
Published: March 2018

ObjectiveTo evaluate the presence of circulating tumour cells (CTCs) at different stages of prostate cancer using the AdnaTest® ProstateCancerDetect kit (Qiagen). Moreover, we aimed to assess the expression of transcripts that are specific for cancer stem cells (AdnaTest StemCell) and epithelial–mesenchymal transition (EMT) in CTCs (AdnaTest EMT), as well as additional genes that are known to promote prostate cancer progression.Patients and MethodsIn this prospective study, we included 81 patients who underwent treatment for prostate cancer between 07/2014 and 02/2015, including: Group A, 18 patients (22.2%) with low‐risk clinically localised prostate cancer; Group B, 25 patients (30.9%) with high‐risk clinically localised prostate cancer; Group C, 11 patients (13.6%) with metastatic castration‐sensitive prostate cancer (mCSPC); and Group D, 27 patients (33.3%) with metastatic castration‐resistant prostate cancer (mCRPC). AdnaTest ProstateCancer and AdnaTest StemCell/EMT were performed in all cases. In addition, expression of the androgen receptor (AR), c‐met, c‐kit and thymidylate synthase (TYMS) in CTCs was assessed using specific polymerase chain reaction assays.ResultsA positive AdnaTest ProstateCancer was present in three (16.7%), two (8.0%), six (54.5%) and 19 (70.5%) patients in groups A, B, C and D, respectively (P < 0.01, chi‐squared test). The AdnaTest EMT and AdnaTest StemCell were positive in zero (0.0%), zero (0.0%), one (9.1%), and two (7.4%); and in five (27.8%), four (16.0%), three (27.3%), and 11 (40.7%) patients in groups A, B, C and D, respectively, with no significant differences noted between groups. CTCs expressing TYMS (44.4% and 50.0% vs 13.9%) or AR (18.2% and 25.9% vs 0.0%) were seen more commonly in patients in groups C and D vs patients with non‐metastatic disease (all P < 0.05). Expression of c‐kit and c‐met were rare events, with only two patients positive for either marker.ConclusionsAdnaTest ProstateCancerDetect exhibits positive results mainly in patients with metastatic disease. Expression of AR and TYMS are frequent events in CTCs of patients with advanced disease, whereas c‐met and c‐kit gene expression is seen in only a small proportion of patients. The implications of these results for the use of CTC analysis as a decision factor for personalised treatment strategies in advanced prostate cancer remain to be determined.
Rational design of isonicotinic acid hydrazide derivatives with antitubercular activity: Machine learning, molecular docking, synthesis and biological testing
Authors: Kovalishyn Vasyl , Grouleff Julie , Semenyuta Ivan , Sinenko Vitaliy O. , Slivchuk Sergiy R. , Hodyna Diana , Brovarets Volodymyr , Blagodatny Volodymyr , Poda Gennady , Tetko Igor V. , Metelytsia Larysa 
Published: March 2018

The problem of designing new antitubercular drugs against multiple drug‐resistant tuberculosis (MDR‐TB) was addressed using advanced machine learning methods. As there are only few published measurements against MDR‐TB, we collected a large literature data set and developed models against the non‐resistant H37Rv strain. The predictive accuracy of these models had a coefficient of determination q2 = .7–.8 (regression models) and balanced accuracies of about 80% (classification models) with cross‐validation and independent test sets. The models were applied to screen a virtual chemical library, which was designed to have MDR‐TB activity. The seven most promising compounds were identified, synthesized and tested. All of them showed activity against the H37Rv strain, and three molecules demonstrated activity against the MDR‐TB strain. The docking analysis indicated that the discovered molecules could bind enoyl reductase, InhA, which is required in mycobacterial cell wall development. The models are freely available online (http://ochem.eu/article/103868) and can be used to predict potential anti‐TB activity of new chemicals.
2S protein Ara h 7.0201 has unique epitopes compared to other Ara h 7 isoforms and is comparable to 2S proteins Ara h 2 and 6 in basophil degranulation capacity
Authors: Hayen S. M. , Ehlers A. M. , den Hartog Jager C. F. , Garssen J. , Knol E. F. , Knulst A. C. , Suer W. , Willemsen L. E. M. , Otten H. G. 
Published: March 2018

SummaryBackgroundScreening for specific IgE against 2S albumin proteins Ara h 2 and 6 has good positive predictive value in diagnosing peanut allergy. From the third 2S member Ara h 7, 3 isoforms have been identified. Their allergenicity has not been elucidated.ObjectiveThis study investigated the allergenicity of Ara h 7 isoforms compared to Ara h 2 and 6.MethodsSensitization of 15 DBPCFC‐confirmed peanut‐allergic patients to recombinant Ara h 2.0201, Ara h 6.01 and isoforms of recombinant Ara h 7 was determined by IgE immunoblotting strips. A basophil activation test (BAT) was performed in 9 patients to determine IgE‐cross‐linking capacities of the allergens. Sensitivity to the allergens was tested in 5 patients who were sensitized to at least 1 Ara h 7 isoform, by a concentration range in the BAT. 3D prediction models and sequence alignments were used to visualize differences between isoforms and to predict allergenic epitope regions.ResultsSensitization to Ara h 7.0201 was most frequent (80%) and showed to be equally potent as Ara h 2.0201 and 6.01 in inducing basophil degranulation. Sensitization to Ara h 7.0201 together with Ara h 2.0201 and/or 6.01 was observed, indicating the presence of unique epitopes compared to the other 2 isoforms. Differences between the 3 Ara h 7 isoforms were observed in C‐terminal cysteine residues, pepsin and trypsin cleavage sites and 3 single amino acid substitutions.Conclusion & clinical relevanceThe majority of peanut‐allergic patients are sensitized to isoform Ara h 7.0201, which is functionally as active as Ara h 2.0201 and 6.01. Unique epitopes are most likely located in the C‐terminus or an allergenic loop region which is a known allergenic epitope region for Ara h 2.0201 and 6.01. Due to its unique epitopes and allergenicity, it is an interesting candidate to improve the diagnostic accuracy for peanut allergy.
Social workers' emotional labour with families in poverty: Neoliberal fatigue?
Authors: Lavee Einat , Strier Roni 
Published: March 2018

AbstractThis study examines the emotional labour of social workers serving families living in poverty. Based on in‐depth interviews and focus groups, the study concentrates on frontline social workers' emotions when faced with increasing levels of poverty, growing caseloads, and neoliberal social policies in Israel. Findings highlight 3 interrelated aspects of the emotional labour of social workers involved with impoverished families: (a) the emotional flooding social workers experience in their professional routines, (b) the various practices of emotional labour they use to cope with the emotional backlash of their encounters with these families including emotional numbness, emotional Othering, and emotional splitting, and (c) confirmation of the harmful influence of institutional policies on their emotional well‐being and ability to respond effectively to the increasing demands of their clients. Based on Hochschild's theory of emotional labour, we maintain that social workers' emotions should be studied in the context of a specific social, institutional, and political background.
Multiplex PCR in noninvasive prenatal diagnosis for FGFR3‐related disorders
Authors: Terasawa Sumire , Kato Asuka , Nishizawa Haruki , Kato Takema , Yoshizawa Hikari , Noda Yoshiteru , Miyazaki Jun , Ito Mayuko , Sekiya Takao , Fujii Takuma , Kurahashi Hiroki 
Published: March 2018

ABSTRACTThanatophoric dysplasia and achondroplasia are allelic disorders caused by a constitutively active mutation in the FGFR3 gene. Because thanatophoric dysplasia is a lethal disorder and achondroplasia is non‐lethal, they need to be distinguished after ultrasound identification of fetal growth retardation with short limbs. Accordingly, we have developed a noninvasive prenatal test using cell‐free fetal DNA in the maternal circulation to distinguish thanatophoric dysplasia and achondroplasia. A multiplex PCR system encompassing five mutation hotspots in the FGFR3 gene allowed us to efficiently identify the responsible mutation in cell‐free DNA in all examined pregnancies with a suspected thanatophoric dysplasia or achondroplasia fetus. This system will be helpful in the differential diagnosis of thanatophoric dysplasia and achondroplasia in early gestation and in couples concerned about the recurrence of thanatophoric dysplasia due to germinal mosaicism.