bluuebunny/crossref_metadata_2025_split huggingface dataset:
Condutas de enfermagem diante das vítimas de ferimentos por armas de fogo em serviço de atendimento móvel de urgência
Authors: Alves Jobson Henrique Silveira , Barreto Marcelo Alves , Bezerra Wilma Kátia Trigueiro , Bezerra Anne Milane Formiga , Nobre Auricélia de Sousa 
Published: October 2018

O atendimento pré-hospitalar é fundamental para pacientes vítimas de ferimento por arma de fogo, pois é essencial na redução das sequelas decorrentes da mesma, assim como para melhores condições de sobrevida das vítimas. As lesões provenientes por disparos de arma de fogo são uma das mais incidentes formas de violência atualmente, representando um problema de saúde pública pela frequência com que ocorre; devido a fatores como este, vê-se a importância da assistência de enfermagem qualificada ainda na cena da ocorrência. O estudo objetiva descrever as condutas do enfermeiro atuante no Serviço de Atendimento Móvel de Urgência (SAMU) frente às ocorrências com vítimas Ferimentos por Armas de Fogo (FAF). O estudo é do tipo descritivo, exploratório, com abordagem quantiqualitativa, com participação de nove enfermeiras mediante assinatura do Termo de Consentimento Livre e Esclarecido, através de um questionário contendo perguntas objetivas e subjetivas. Os resultados mostram 56% dos entrevistados revelam não enfrentar dificuldades na assistência as vítimas de FAF, porém os relatados foram em relação a segurança da equipe e a falta de auxílio para conter os cidadãos que acompanham o atendimento com curiosidade; 100% da amostra participaram de cursos de treinamento. Em relato todas as enfermeiras entrevistadas já prestaram conduta a vítima de FAF e a consideram a assistência de enfermagem prestada no atendimento pré-hospitalar (APH) como resolutiva. Nursing conducts front of victims injured by firearms in emergency mobile care serviceAbstract: The prehospital care is critical to patient injury victims by firearms, it is essential to reduce the consequences resulting from it, as well as better conditions of survival of the victims. Injuries from firearm shots are one of the incidents forms of violence currently representing a public health problem by the frequency with which it occurs; due to factors like this, we see the importance of skilled nursing care still at the scene of the occurrence. The study aims to describe the behavior of nurses who work in the Mobile Emergency Service (SAMU) compared to occurrences with victims injuries by firearms (FAF). The study is a descriptive, exploratory, with quantitative and qualitative approach, with participation of nine nurses by signing the Informed Consent and Informed through a questionnaire with objective and subjective questions. The results show 56% of respondents reveal not face difficulties in assisting the victims of FAF, but were reported with respect to safety of staff and the lack of assistance to contain the citizens accompanying the service with curiosity; 100% of the sample participated in training courses. In reporting all nurses surveyed already conduct provided the victim of FAF and consider nursing care in pre-hospital care (APH) as termination.
SEARCH OF THE STRESS INDUSED VENTRICULAR TACHICARDIA REASONS — THE METABOLIC THERAPY OPPORTUNITIES
Authors: Treshkur T. V. , Tatarinova A. A. , Ryngach E. A. 
Published: October 2018

A clinical case of a 56-year-old man is presented in which only ventricular tachycardia without clinical and ECG criteria of myocardial ischemia is recorded on the exercise test. The ventricular tachycardia was the only reason for stopping the test. This clinical case demonstrates all the difficulties in determining the genesis of ventricular arrhythmias induced by exercise. The purpose of the work was to show all the difficulties in determining the genesis of exercise-induced ventricular arrhythmia. The literature references related to the exercise-induced ventricular arrhythmia differentiation is rather poor. It is only known that if a patient develops and progresses ventricular arrhythmia, a tredmill test is considered questionable. Exerciseinduced ventricular arrhythmias especially ventricular tachycardia, are the most dangerous. Therefore, additional diagnostic methods were used to reveal the main disease as the background of ventricular tachycardia. Results of pharmacological test with nitroglycerine were the indication of the ischemic origin of ventricular tachycardia. Coronary angiography did not reveal coronary artery stenoses. Positron emission tomography revealed coronary microcirculation disturbance after which a decision about metabolic therapy with Mexicor was made. The correct choice of the drug (Mеxisor) was confirmed by the results of control studies — improvement of metabolism and antiarrhythmic effect. The article concludes that the choice of the treatment exercise-induced ventricular arrhythmia in patients with stable coronary artery disease should be individual and pathogenetic.
Manejo nutricional de la esclerosis lateral amiotrófica: resumen de recomendaciones
Authors: Del Olmo García M.ª Dolores , Virgili Casas Nuria , Cantón Blanco Ana , Lozano Fuster Francisca Margarita , Wanden-Berghe Carmina , Avilés Victoria , Ashbaugh Enguídanos Rosana , Ferrero López Isabel , Molina Soria Juan Bautista , Montejo González Juan Carlos , Bretón Lesmes Irene , Álvarez Hernández Julia , Moreno Villares José Manuel , SENPE Grupo de Trabajo de Ética de la Socieda 
Published: October 2018

Como Coordinadora del Grupo de Ética de la Sociedad Española de Nutrición Clínica y Metabolismo (SENPE), me complace remitirle el documento elaborado por nuestro grupo de trabajo, del que nos sentimos especialmente satisfechos, en relación al tratamiento nutricional en la esclerosis lateral amiotrófica (ELA): MANEJO NUTRICIONAL DE LA ESCLEROSIS LATERAL AMIOTRÓFICA: RESUMEN DE RECOMENDACIONES. Agradeceríamos fuese valorado para publicación en el órgano de expresión de nuestra Sociedad, la revista Nutrición Hospitalaria, como documento de Grupos de Trabajo. Esperamos que dicho texto sea útil y sirva como guía terapéutica orientativa a los profesionales que tratan pacientes con dicha patología, en el ámbito de la Nutrición, y redunde en la mejoría de la atención a nuestros pacientes con ELA.
El servicio económico-político como culto antifetichista. Aproximación a la «obra temprana» de Enrique Dussel desde la perspectiva de la «ética arqueológica»
Authors: Zielinski Juan Matías 
Published: October 2018

En este artículo se realizará un análisis pormenorizado dela relación que presenta Enrique Dussel en su «obra temprana»filosófica entre el servicio económico-político y el culto antifetichista. En el primer apartado, se analizará sistemáticamente la categoríade «fetichismo», la que permite comprender los procesos de«fetichización ontológica» de los sistemas históricos. En principio,se presentará la religión como «ideología supraestructural fetichista»y el proceso de fetichización como sacralización o divinización decualquier sistema histórico («totalización totalitaria»). En ello, sedescribirá la relación analógica entre el fetiche moderno (capital) y lafigura bíblica del «ídolo» (como Moloch o Mammón). En el segundoapartado, se explicará de qué manera la arqueológica liberadora seposiciona como una instancia atea de negación del dios-del-sistema.Luego se explicará el modo mediante el cual el ateísmo puede sercomprendido como una instancia propedéutica para la afirmación deun Absoluto alterativo (Dios-Otro), a partir de la dialéctica profeta-rey(«ateísmo por afirmación»). En el tercer apartado, se presentará lanoción hebrea ‘avodáh en referencia al trabajo-servicio económicopolíticocomo culto. Allí, a partir de una meta-física materialista yde la contingencia, analizaré las categorías fundamentales para eldesarrollo cúltico-profético de la praxis de liberación.
Anterior Mandibular Segmental Distraction Osteogenesis: A Case Report
Authors: Starch-Jensen Thomas , Kjellerup Annette Dalgaard 
Published: October 2018

Introduction:
Skeletal Angle Class I patients with a severe dental Class II malocclusion are characterized by an unfavourable anterior-posterior relationship between the anterior dentoalveolar area and the skeletal base. Orthodontic alignment posing various treatment difficulties and surgical correction with bilateral sagittal split osteotomy may result in a compromised facial profile. Hence, anterior mandibular segmental distraction osteogenesis has been proposed as an alternative treatment modality for solving facial esthetics, anterior tooth crowding and an unfavourable relationship between the anterior dentoalveolar area and the skeletal base in skeletal Angle Class I patients with a severe dental Class II malocclusion. Limited skeletal relapse with predictable soft tissue changes have been documented in long-term studies. Thus, anterior mandibular segmental distraction osteogenesis seems to be a valuable and predictable surgical method for correction of selected cases of skeletal Class I patients with a severe dental Class II malocclusion.

Case report:
The purpose of this case report is to present the treatment of a 57-year-old female with a skeletal Angle Class I relation and a severe dental Class II malocclusion. Anterior mandibular segmental distraction osteogenesis as well as discussing the current knowledge about this treatment modality.

Conclusion:
The present case report illustrates that establishment of a harmonious relationship between the maxillary and mandibular arch in patients with a skeletal Angle Class I relation and a severe dental Class II malocclusion using anterior mandibular segmental distraction osteogenesis seems to be a predictable and applicable surgical method for selected cases and General Dental Practitioners, orthodontics and maxillofacial surgeons must have knowledge of this treatment modality.
To Evaluate the Severity, Distribution of Occlusal Tooth Wear and its Correlation with Bite Force in Young North Indian Adults
Authors: Kumar Mandeep , Verma Rashmi , Bansal Mohit , Singh Sunint , Rehan Sharique , Kumar Virender , Simran Dr. 
Published: October 2018

Aim:
To determine the severity and distribution of occlusal tooth wear among young North Indian adults and to evaluate the correlation of occlusal tooth wear with bite force.

Materials and Methods:
A total of 164 subjects were enrolled in the present study. Inclusion criteria included subjects with age range of 25-40 years having a full complement of natural dentition (excluding third molars), with no history of orthodontic treatment, FPD and trauma. Maxillary and mandibular casts of each subject were taken. Tooth wear score of anterior and posterior teeth of both the arches was calculated using a five-point (0 to 4) ordinal scoring system. The calculated tooth wear scores were then compared with data concerning age, sex, number of daily meals, vegetarian/non-vegetarian diet, Group function/Canine guided occlusion and bite force. Nonparametric (Mann-Whitney) test was used to determine the relationship between various factors and occlusal tooth wear. Spearman’s correlation coefficient was used to determine the correlation between tooth wear and bite force.

Results:
After applying statistical analysis to the data collected, total tooth wear score of the whole sample was 30.07 ± 6.39. Anterior teeth had significantly higher wear score than posteriors (P < 0.01). Males showed significantly higher (P < 0.001) tooth wear in both arches factors such as bite force and age showed significant correlation with tooth wear (P=0.000), however, the number of meals taken per day did not show any significant correlation. Higher tooth wear loss was seen in non vegetarian dietary pattern but it was statistically insignificant. It was also found that Group function occlusion showed significantly higher mean tooth wear loss 45.76 ± 9.19 as compared to Canine guided occlusion 26.37 ± 10.68 (P=0.000).
Minimal Increase in Total Hip Arthroplasty Surgical Procedural Time with the Use of a Novel Surgical Navigation Tool
Authors: Christ Alexander , Ponzio Danielle , Pitta Michael , Carroll Kaitlin , Muir Jeffrey M. , Sculco Peter K. 
Published: October 2018

Background:
Computer-assisted navigation has proven effective at improving the accuracy of component placement during Total Hip Arthroplasty (THA); however, the material costs, line-of-site issues and potential for significant time increases have limited their widespread use.

Objective:
The purpose of this study was to investigate the impact of an imageless navigation device on surgical time, when compared with standard mechanical guides.

Methods:
We retrospectively reviewed prospectively collected data from 61 consecutive primary unilateral THA cases (posterior approach) performed by a single surgeon. Procedural time (incision to closure) for THA performed with (intervention) or without (control) a computer-assisted navigation system was compared. In the intervention group, the additional time associated with the use of the device was recorded. Mean times were compared using independent samples t-tests with statistical significance set a priori at p<0.05.

Results:
There was no statistically significant difference between procedural time in the intervention and control groups (102.3±28.3 mins vs. 99.1±14.7 mins, p=0.60). The installation and use of the navigation device accounted for an average of 2.9 mins (SD: 1.6) per procedure, of which device-related setup performed prior to skin incision accounted for 1.1 mins (SD: 1.1) and intra-operative tasks accounted for 1.6 mins (SD: 1.2).

Conclusion:
In this series of 61 consecutive THAs performed by a single surgeon, the set-up and hands-on utilization of a novel surgical navigation tool required an additional 2.9 minutes per case. We suggest that the intraoperative benefits of this novel computer-assisted navigation platform outweigh the minimal operative time spent using this technology.
Exosome Biogenesis and Biological Function in Response to Viral Infections
Authors: Crenshaw Brennetta J. , Gu Linlin , Sims Brian , Matthews Qiana L. 
Published: October 2018

Introduction:Exosomes are extracellular vesicles that originate as intraluminal vesicles during the process of multivescular body formation. Exosomes mediate intercellular transfer of functional proteins, lipids, and RNAs. The investigation into the formation and role of exosomes in viral infections is still being elucidated. Exosomes and several viruses share similar structural and molecular characteristics.Explanation:It has been documented that viral hijacking exploits the exosomal pathway and mimics cellular protein trafficking. Exosomes released from virus-infected cells contain a variety of viral and host cellular factors that are able to modify recipient host cell responses. Recent studies have demonstrated that exosomes are crucial components in the pathogenesis of virus infection. Exosomes also allow the host to produce effective immunity against pathogens by activating antiviral mechanisms and transporting antiviral factors between adjacent cells.Conclusion:Given the ever-growing roles and importance of exosomes in both host and pathogen response, this review will address the impact role of exosome biogenesis and composition after DNA, RNA virus, on Retrovirus infections. This review also will also address how exosomes can be used as therapeutic agents as well as a vaccine vehicles.
Computational Studies on Imidazo[1,2-a] Pyridine-3-Carboxamide Analogues as Antimycobacterial Agents: Common Pharmacophore Generation, Atom-based 3D-QSAR, Molecular dynamics Simulation, QikProp, Molecular Docking and Prime MMGBSA Approaches
Authors: Mali Suraj N. , Chaudhari Hemchandra K. 
Published: October 2018

Background:
IMB-1402, Q203 and ND09759 analogs were found to have strong efficiency against Multi-drug-resistant tuberculosis (MDR-TB)/Extensively drug-resistant tuberculosis (XDR-TB) strains.

Objectives:
To know the structural necessities for imidazo[1,2-a]pyridine-3-carboxamide analogues, we intended to develop the ligand-based pharmacophore, Quantitative structure–activity relationship models(3D-QSAR model). We also performed Molecular docking, molecular simulation and Prime/Molecular Mechanics Generalized Born Surface Area (Prime/MM-GBSA) studies.

Methods:
All the studies like Common pharmacophore hypothesis generation, Atom based 3D-QSAR study, Prime MMGBSA, Docking, Qikprop, and Molecular dynamics simulation were processed using various modules incorporated within the maestro software interface from Schrodinger, LLC, New York USA (release 2017).

Results:
The common pharmacophore hypothesis(CPH) generation resulted in a five-featured hypothesis HHPRR, containing 1 positive, 2 hydrophobic and 2 aromatic rings. An Atom-based 3D-QSAR model was predicted for twenty seven training sets (a correlation coefficient i.e.R2= 0.9181,Standard deviation i.e.SD =0.3305, variance ratio i.e. F = 85.9) and eleven test sets (cross-validation correlation coefficient i.e.Q2 =0.6745, Root Mean Square Error i.e. RMSE = 0.65, Pearson R = 0.8427, P=1.21E-12) compounds employing alignment based on CPH. The dataset of thirty-eight molecules was allowed for docking into the active site of pantothenate synthetase (PDBID-3IVX) that shows H-bonding (Hydrogen bonding) interactions with residues Gly158, Met195, Pro38 and additionally shows further Pi-cation interactions with a residue like Hie47. We also obtained good simulation results for1.2ns study.

Conclusion:
From the results, the generated 3D-QSAR model may be applicable for additional designing of various novel potent derivatives in the future.
Pharmacokinetics, Pharmacodynamics, and Modulation of Hepatic Glucose Production With Insulin Glargine U300 and Glargine U100 at Steady State With Individualized Clinical Doses in Type 1 Diabetes
Authors: Porcellati Francesca , Lucidi Paola , Candeloro Paola , Cioli Patrizia , Marinelli Andreoli Anna , Curti Gianluca , Bolli Geremia B. , Fanelli Carmine G. 
Published: October 2018

OBJECTIVE
This study characterized the pharmacokinetics (PK), pharmacodynamics (PD), and endogenous (hepatic) glucose production (EGP) of clinical doses of glargine U300 (Gla-300) and glargine U100 (Gla-100) under steady-state (SS) conditions in type 1 diabetes mellitus (T1DM).

RESEARCH DESIGN AND METHODS
T1DM subjects (N = 18, age 40 ± 12 years, T1DM duration 26 ± 12 years, BMI 23.4 ± 2 kg/m2, A1C 7.19 ± 0.52% [55 ± 5.7 mmol · mol−1−1]) were studied after 3 months of Gla-300 or Gla-100 (evening dosing) titrated to fasting euglycemia (random, crossover) with the euglycemic clamp using individualized doses (Gla-300 0.35 ± 0.08, Gla-100 0.28 ± 0.07 units · kg−1).

RESULTS
Plasma free insulin concentrations (free immunoreactive insulin area under the curve) were equivalent over 24 h with Gla-300 versus Gla-100 (point estimate 1.11 [90% CI 1.03; 1.20]) but were reduced in the first 6 h (0.91 [90% CI 0.86; 0.97]) and higher in the last 12 h postdosing (1.38 [90% CI 1.21; 1.56]). Gla-300 and Gla-100 both maintained 24 h euglycemia (0.99 [90% CI 0.98; 1.0]). The glucose infusion rate was equivalent over 24 h (1.03 [90% CI 0.88; 1.21]) but was lower in first (0.77 [90% CI 0.62; 0.95]) and higher (1.53 [90% CI 1.23; 1.92]) in the second 12 h with Gla-300 versus Gla-100. EGP was less suppressed during 0–6 h but more during 18–24 h with Gla-300. PK and PD within-day variability (fluctuation) was 50% and 17% lower with Gla-300.

CONCLUSIONS
Individualized, clinical doses of Gla-300 and Gla-100 resulted in a similar euglycemic potential under SS conditions. However, Gla-300 exhibited a more stable profile, with lower variability and more physiological modulation of EGP compared with Gla-100.
Buy One, Get One Free: How Framing Sales Promotions Affects the Whole Shopping Basket
Authors:   MIR Editors
Published: October 2018

Abstract
According to this study, sales promotions not only affect the sales of promoted items, but also of unpromoted brands and, therefore, the whole shopping basket. The authors demonstrated, in a series of experiments, that the framing of promotions matters. Specific promotions motivate consumers to add more items to their baskets if they are well aligned with the shoppers´ dominant shopping orientation as well as different types of brands. Well-known brands, which represent safe choices, worked well with a savings orientation and with coupons framed as “Save $x” and “Buy one, get one free”. Less familiar brands, which represent a need for variety, were consistent with a promotion focus and with coupons framed as “Get $x off”. Well-known brands were also more compatible with immediately expiring coupons, whereas less familiar brands were compatible with coupons that have longer time horizons.
For retailers, it seems advisable to have a closer look at consumer shopping orientations. Among the design variables for promotions, the framing of the savings message and the expiration date restriction are important variables. Depending on the individual shopping orientation, the right cues positively influence whole shopping baskets and hence sales. Further, consistency is beneficial between the positioning strategies used to differentiate themselves from other retailers (e.g., everyday low-price strategies as opposed to value oriented positions) and their price promotional strategies.
The Effect Of Phototherapy (24 Hours) Towards Jaundice Degrees Of The Newborn In Hospital NICU West Nusa Tenggara Province
Authors: Selung Rosalia , Wasliah Indah , Pratiwi Eka Adithya 
Published: October 2018

Background: Aximately 60% of normal birth infant become jaundiced in the first week of birth. The incidence of jaundice in the West Nusa Tenggara hospital in 3 years later (2012-2014) there were 1166 cases. Phototherapy of total serum bilirubin (TSB) increased. Clinical trials have validated the efficacy phototherapy in reducing excessive unconjugated hyperbilirubinemia, and its implementation has been drastically confine the use of exchange transfusion (Bhutani, 2011). Objective:The purpose of this study was to determine the degree of jaundice before and after phototherapy, as well as analyze the influence phototherapy before and after the degree of jaundice in the newborn. Method:This type of research is pre-experimental research design using the approach one group pre-test and post-test design. The study population was all jaundice infants who were treated at Hospital NICU room in West Nusa Tenggara Provence in May 2016. The sample was 15 respondents with acsidental sampling techniques. The method of data analysis with descriptive percentage univariate and bivariate analysis with test of rank correlation test (spearman) obtained significance value p = 0.000 < 0.05 and spearman correlation coefficients obtained by value p = 0.025 which means there is a strong correlation between the influence of phototherapy (24 hours) the degree of jaundice in the newborn. Result: The results were obtained degree of jaundice before phototherapy is as many as 9 degree 4 respondents (60%) and as many as 6 degrees five respondents (40%). After 24 hours phototherapy all respondents decreased the degree of jaundice and most have some degreen of jaundice 3 of 10 respondents (66,7%) by 5 respondents (33,3%). Discussion:Recommendations can be given is a gift phototherapy to decrease the degree of jaundice.