bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotective Methodologies of Co-Enzyme Q10 Mediated Brain Hemorrhagic Treatment: Clinical and Pre-Clinical Findings
Authors: Rajdev Kajal , Mehan Sidharth 
Published: June 2019

:Cerebral brain hemorrhage is associated with the highest mortality and morbidity despite only constituting approximately 10-15% of all strokes classified into intracerebral and intraventricular hemorrhage where most of the patients suffer from impairment in memory, weakness or paralysis in arms or legs, headache, fatigue, gait abnormality and cognitive dysfunctions. Understanding molecular pathology and finding the worsening cause of hemorrhage will lead to explore the therapeutic interventions that could prevent and cure the disease. Mitochondrial ETC-complexes dysfunction has been found to increase neuroinflammatory cytokines, oxidative free radicals, excitotoxicity, neurotransmitter and energy imbalance that are the key neuropathological hallmarks of cerebral hemorrhage. Coenzyme Q10 (CoQ10), as a part of the mitochondrial respiratory chain can effectively restore these neuronal dysfunctions by preventing the opening of mitochondrial membrane transition pore, thereby counteracting cell death events as well as exerts an anti-inflammatory effect by influencing the expression of NF-kB1 dependent genes thus preventing the neuroinflammation and energy restoration. Due to behavior and biochemical heterogeneity in post cerebral brain hemorrhagic pattern different preclinical autologous blood injection models are required to precisely investigate the forthcoming therapeutic strategies. Despite emerging pre-clinical research and resultant large clinical trials for promising symptomatic treatments, there are very less pharmacological interventions demonstrated to improve post operative condition of patients where intensive care is required. Therefore, in current review, we explore the disease pattern, clinical and pre-clinical interventions under investigation and neuroprotective methodologies of CoQ10 precursors to ameliorate post brain hemorrhagic conditions.
Link Stability Based Approach for Route Discovery in MANET Using DSR
Authors: Wadhwani Ganesh K. , Khatri Sunil K. , Muttoo Sunil K. 
Published: June 2019

Background:
Mobile Ad-hoc network is a set of devices which are capable of communicating
with each other without the help of any central entity or fixed infrastructure. The absence of fixed access
points makes MANET flexible and deployable at the extreme geographical territories. Each device has
routing capabilities to facilitate communication among nodes in the network.

Objectives:
1) To selects the stable path which has lowest hop count.

2) To use backup path in case of link break up to minimize delay incurred in finding out the alternate path.

Methods:
Dynamic source routing is modified to choose the most stable path and a backup path is cached
to save the route discovery time in case of link failure.

Results:
The modified-DSR based on Link stability and hop count is performing better as compared to
DSR most of the time.

Conclusion:
A modified-DSR is proposed that selects the path using hop count and link stability as parameters.
The advantage of modified-DSR is that if a link breaks in between data communication then
back up path can be used for carrying out the data transfer. Analysis is done by varying the node density
and counting number of packets received .Modified-DSR gives better results for light to moderate network
and DSR performs better if the number of nodes increases beyond a certain limit.
Prediction of Tetralogy of Fallot using Fuzzy Clustering
Authors: Devi K.R. Kosala , Deepa V. 
Published: June 2019

Background:
Congenital Heart Disease is one of the abnormalities in your heart's structure.
To predict the tetralogy of fallot in a heart is a difficult task. Cluster is the collection of data objects,
which are similar to one another within the same group and are different from the objects in the other
clusters. To detect the edges, the clustering mechanism improve its accuracy by using segmentation,
Colour space conversion of an image implemented in Fuzzy c-Means with Edge and Local Information.

Objective:
To predict the tetralogy of fallot in a heart, the clustering mechanism is used. Fuzzy c-Means
with Edge and Local Information gives an accuracy to detect the edges of a fallot to identify the congential
heart disease in an efficient way.

Methods:
One of the finest image clustering methods, called as Fuzzy c-Means with Edge and Local Information
which will introduce the weights for a pixel value to increase the edge detection accuracy value.
It will identify the pixel value within its local neighbor windows to improve the exactness. For evaluation
, the Adjusted rand index metrics used to achieve the accurate measurement.

Results:
The cluster metrics Adjusted rand index and jaccard index are used to evaluate the Fuzzy c-
Means with Edge and Local Information. It gives an accurate results to identify the edges. By evaluating
the clustering technique, the Adjusted Rand index, jaccard index gives the accurate values of 0.2,
0.6363, and 0.8333 compared to other clustering methods.

Conclusion:
Tetralogy of fallot accurately identified and gives the better performance to detect the edges.
And also it will be useful to identify more defects in various heart diseases in a accurate manner.
Fuzzy c-Means with Edge and Local Information and Gray level Co-occurrence matrix are more promising
than other Clustering Techniques.
A Method for Webpage Classification Based on URL Using Clustering
Authors: Sunita  , Singh Gurvinder , Rana Vijay 
Published: June 2019

Background:
Pattern mining is the mechanism of extracting useful information from a
large dataset of information. A sub-field of web mining is sequential Noisy data extraction from user
query, which is considered along with redundancy handling. This redundancy handling mechanism employed
in the existing literature is known as ambiguity handling. The clustering mechanism employed in the
existing system includes k means, semantic search and incremental growth of the internet.

Aims:
The proposed works comprise an analysis of techniques used to extract useful URLs to replace
noisy data.

Methods:
We consider noisy data extraction from user query considered along with the redundancy
handling. This redundancy handling mechanism employed in the existing literature is known as ambiguity
handling. The clustering mechanism used in the existing system includes k means and semantic
search. These mechanisms are static, causing performance degradation in terms of execution
time. It suggests the performance improvement mechanism in this literature.

Results:
The methods MPV (Most-Probable-Values) clustering and N-gram techniques for improvement
considered in existing literature can further be improved using the research methodology
specified through this literature.

Conclusion:
In the proposed system, results are based on MPV clustering with N-grams techniques.
N-gram analyzes the instances of a word or phrase across all query data. The parameters fetch the
results in terms of execution time and the number of URLs retrieves for web page classification.
In the Back Drop of Overuse of Synthetic Drugs, can Botanicals be One of the Answers: A Pilot Study on the Medicinal Use of Chlorophytum and Curcuma by Tribals of Central India
Authors: Miraj Shaima S.A. , Parveen Naima , Chaudhari Sangita A. 
Published: June 2019

Background:
In several recent surveys, it has been found that more people suffer
because of over and indiscriminate use of synthetic drugs, chemicals and antibiotics, particularly
with regard to issues like drug sensitivity, resistance, immune disturbances, and economic
burdens, ultimately leading to a weak prognosis of a large number of diseases, eventually
defeating the purpose of medicinal efficacy. We propose the old age use of scientifically
validated natural compounds of plants and their products for a strong immune system
along with a successful treatment regimen which can be effective as well as safe without side
effects.

Objective:
The aim of the present work is to evaluate the various medicinal uses and applicability
of Chlorophytum borivilianum, Chlorophytum tuberosum and Curcuma longa as
natural plant-based ingredients by tribal communities.

Methods:
A survey was carried on the rural folks who used natural botanicals for alleviating
their several common disorders successfully. Chlorophytum species of Liliaceae and Curcuma
of Zingiberaceae are traditional rare Indian medicinal herbs widely used in the indigenous
system of medicine since ancient time. A total number of 196 individuals were interviewed
which included both men and women, in which the main objective was to explore the
different forms of these medicinal plant species used with water or with milk by tribal folk
for their wide range of common ailments such as pain in joints, loss of appetite, cold, sore
throat, fever and general weakness.

Results:
The tribal people were found to use these plants for many of their problems such as
physical weakness, natal and postnatal problems, lactation problems, cold and fever, sore
throat, inflammation, joint pain, etc. Many of them (60-80%) were able to overcome their
varied health problems to a great extent such as inflammation (69.4%), joint pain and arthritis
(66.6%), sore throat and cold (87.5%), physical weakness (66%), natal and postnatal
problems (75%).

Conclusion:
The findings strongly support the use of natural compounds for a safe and effective
means of treating loss of appetite, general weakness, pain of the joints, inflammation
and other related ailments by the people of tribal areas of Border States of MP and Maharashtra,
having little access to modern health care facilities.
Social Media Coverage of Scientific Articles Immediately After Publication Predicts Subsequent Citations - #SoME_Impact Score: Observational Analysis
Authors: Sathianathen Niranjan Jude , Lane III Robert , Murphy Declan G , Loeb Stacy , Bakker Caitlin , Lamb Alastair D , Weight Christopher J 
Published: June 2019

Background
Social media coverage is increasingly used to spread the message of scientific publications. Traditionally, the scientific impact of an article is measured by the number of citations. At a journal level, this conventionally matures over a 2-year period, and it is challenging to gauge impact around the time of publication.

Objective
We, therefore, aimed to assess whether Web-based attention is associated with citations and to develop a predictive model that assigns relative importance to different elements of social media coverage: the #SoME_Impact score.

Methods
We included all original articles published in 2015 in a selection of the highest impact journals: The New England Journal of Medicine, The Lancet, the Journal of the American Medical Association, Nature, Cell, and Science. We first characterized the change in Altmetric score over time by taking a single month’s sample of recently published articles from the same journals and gathered Altmetric data daily from the time of publication to create a mixed effects spline model. We then obtained the overall weighted Altmetric score for all articles from 2015, the unweighted data for each Altmetric component, and the 2-year citation count from Scopus for each of these articles from 2016 to 2017. We created a stepwise multivariable linear regression model to develop a #SoME_Score that was predictive of 2-year citations. The score was validated using a dataset of articles from the same journals published in 2016.

Results
In our unselected sample of 145 recently published articles, social media coverage appeared to plateau approximately 14 days after publication. A total of 3150 articles with a median citation count of 16 (IQR 5-33) and Altmetric score of 72 (IQR 28-169) were included for analysis. On multivariable regression, compared with articles in the lowest quantile of #SoME_Score, articles in the second, third, and upper quantiles had 0.81, 15.20, and 87.67 more citations, respectively. On the validation dataset, #SoME_Score model outperformed the Altmetric score (adjusted R2 0.19 vs 0.09; P<.001). Articles in the upper quantile of #SoME_Score were more than 5 times more likely to be among the upper quantile of those cites (odds ratio 5.61, 95% CI 4.70-6.73).

Conclusions
Social media attention predicts citations and could be used as an early surrogate measure of scientific impact. Owing to the cross-sectional study design, we cannot determine whether correlation relates to causation.
Promoting Smoke-Free Homes Through Biomarker Feedback Documenting Child Exposure to Tobacco Toxins: Protocol for a Randomized Clinical Trial
Authors: Thomas Janet Leigh , Schreier Meredith , Luo Xianghua , Lowry Sue , Hennrikus Deborah , An Lawrence , Wetter David W , Ahluwalia Jasjit S 
Published: June 2019

BackgroundExposure to secondhand smoke (SHS) early in life increases the risk of sudden infant death syndrome (SIDS), asthma, and respiratory illnesses. Since children’s primary exposure to SHS occurs in the home, these most vulnerable members of our society are not fully protected by recent increases in the adoption of smoking bans in public spaces. Although exposure to SHS is a quickly reversible cause of excess morbidity, few low-income homes strictly enforce smoking restrictions.ObjectiveThis study aims to test a novel approach to motivate the adoption of home smoking restrictions and to eliminate child SHS exposure by providing parents with objective data documenting home SHS exposure and “biomarker feedback” of child ingestion of tobacco toxins, that is, objective, laboratory-based results of assays performed on child urine, documenting levels of nicotine; cotinine; and NNAL (4-[methylnitrosamino]-1-[3-pyridyl]-1-butanol), which is a metabolite of the known tobacco carcinogen NNK (4-[methylnitro-samino]-1-[3-pyridyl]-1-butanone).MethodsFrom 2011 to 2013, 195 low-income, female smokers with children aged ≤10 years residing in their homes were recruited into a two-arm randomized clinical trial. Participants were assigned to one of two groups: biomarker feedback (n=98) and health education (n=97). In-home assessments were administered at baseline, week 16, and week 26. Children’s home SHS exposure and nicotine, cotinine, and NNAL levels from urine samples, measured through a passive nicotine dosimeter and a surface sample of residual tobacco smoke (ie, thirdhand smoke), were collected at all three time points. Primary outcome was dosimeter-verified, self-reported complete home smoking restrictions at 6 months after randomization. Secondary outcomes included parental self-report of smoking behavior change and child urine tobacco toxin (biomarker) change.ResultsData collection and analyses are complete, and the results are being interpreted.ConclusionsThe study protocol describes the development of a novel community-based controlled trial designed to examine the efficacy of biomarker feedback documenting home and child exposure to SHS on parental smoking behavior change.International Registered Report Identifier (IRRID)RR1-10.2196/12654
The Presence of Physical Symptoms in Patients With Tinnitus: International Web-Based Survey
Authors: Michiels Sarah , Harrison Stephen , Vesala Markku , Schlee Winfried 
Published: June 2019

Background
Tinnitus, or ringing in the ears, is a phantom perception of sound in the absence of overt acoustic stimulation. Many patients indicate that the perception of their tinnitus is not constant and can vary from moment to moment. This tinnitus fluctuation is one of the diagnostic criteria for somatosensory tinnitus (ST), a tinnitus subtype that is influenced by cervical spine or temporomandibular dysfunctions, although various factors have been reported to cause fluctuations in tinnitus, such as stress, anxiety, and physical activity.

Objective
The aim of this study was twofold: (1) to investigate the presence of physical symptoms in a large group of participants with tinnitus and (2) to investigate if these physical symptoms are more frequently present in a subgroup of participants with ST.

Methods
A Web-based survey, questioning the presence of physical symptoms in a convenience sample of participants with tinnitus, was launched on the online forum, Tinnitus Talk, managed by Tinnitus Hub. After a general analysis of the physical symptoms present in our survey population, we further analyzed the group of participants who were diagnosed by a physician (n=1262). This subgroup was divided into 2 groups, one group diagnosed with ST and another group diagnosed with other types of tinnitus.

Results
In total, 6115 participants with a mean age of 54.08 years (SD 13.8) completed the survey. Physical symptoms were frequently present in our sample of participants with tinnitus: 4221 participants (69.02%) reported some form of neck pain, 429 (7.01%) were diagnosed with temporomandibular disorders, 2730 (44.64%) indicated they have bruxism, and between 858 and 1419 (14.03%-23.20%) participants were able to modulate their tinnitus by voluntary movements. ST was diagnosed in 154 out of 1262 (12.20%) participants whose tinnitus cause was diagnosed by a physician. Symptoms referring to the known diagnostic criteria were evidently more present in the ST group than in the non-ST group. Additionally, participants with ST more often indicated a negative effect of a bad night’s sleep (P=.01) and light intensity exercise (P=.01).

Conclusions
Physical activity and movement (disorders) frequently affect tinnitus severity. Head-neck related symptoms are more frequently reported in the ST group, as is the ability to modulate the tinnitus by head or jaw movements. Additionally, participants with ST more often report fluctuations of their tinnitus and reaction to sleeping difficulties and low intensity exercise.
Arquitetura estratigráfica dos depósitos fluviais albianos da base da Formação São Mateus no norte da Bacia do Espírito Santo
Authors: ALVARENGA Renata Dos Santos , SCHERER Claiton Marlon dos Santos , KUCHLE Juliano , DE ROS Luis Fernando 
Published: June 2019

Os depósitos aluviais da Formação São Mateus (Albiano da Bacia do Espírito Santo, Brasil) consistem em importantes reservatórios. Entretanto, existem poucos trabalhos detalhando a estratigrafia deste intervalo estratigráfico. Em decorrência disso, este trabalho teve por objetivo estabelecer um fatiamento estratigráfico de alta resolução da seção basal desta unidade, a qual é constituída por depósitos fluviais. Diante das dificuldades apresentadas para a correlação estratigráfica desses depósitos, a estratégia de correlação utilizada foi a subdivisão da sucessão aluvial em ciclos estratigráficos. Este método se baseia na variação na razão entre as taxas de criação de acomodação e suprimento sedimentar (A:S) que diretamente controla o grau de amalgamação dos corpos arenosos de canais fluviais. Com isso, foram definidos seis ciclos compostos internamente por tratos de sistemas de alta e baixa acomodação. Esses ciclos refletem a estruturação do arranjo da amalgamação dos canais fluviais com os depósitos externos aos canais através da razão entre a taxa de acomodação (A) e a taxa de influxo sedimentar (S) formando ciclos.
The practices of mathematics education doctoral students
Authors: Monaghan John 
Published: June 2019

This paper looks at the practices (or praxeologies) of mathematics education doctoral students and their supervisors from the perspectives of activity theory and the anthropological theory of the didactic. The paper examines three ways to view mathematics education research before discussing : research methods and methodologies ; the debate on qualitative and quantitative research ; and implications for the supervision of doctoral students.
Economía, ecología y normatividad en la teoría antropológica de lo didáctico
Authors: Gascón Josep , Nicolás Pedro 
Published: June 2019

. Si bien nadie afirmaría que ciencias tales como la física o la biología puedan emitir juicios valorativos y normativos, la cuestión es más problemática en el caso de las denominadas ciencias sociales. En efecto, al principio del siglo XX tuvo lugar una importante controversia, en la que Max Weber desempeñó un papel destacado, sobre si las ciencias sociales como la sociología y la economía podían, e incluso debían, emitir juicios de valor, y no parece que actualmente la controversia esté completamente zanjada. En este trabajo plantearemos abiertamente la cuestión del tipo de aseveraciones que la didáctica puede emitir y propondremos una respuesta desde la teoría antropológica de lo didáctico (TAD) como punto de partida de un diálogo con otros enfoques teóricos en didáctica.
Des liens entre l’organisation de savoir et l’organisation de l’étude dans l’analyse praxéologique
Authors: Artuad Michèle 
Published: June 2019

. L’élaboration d’un modèle praxéologique demande de distinguer entre les éléments de l’organisation de savoir enjeu de l’étude, d’une part, et, d’autre part, certains ingrédients de l’organisation de l’étude qui permet l’émergence de cette organisation de savoir. Que peut-on mettre dans le modèle d’une praxéologie et que ne peut-on y intégrer ? Quels sont les aspects d’une organisation de l’étude qui peuvent venir s’intégrer dans une organisation de savoir et comment peuvent-ils le faire ? Quels problèmes cela pose-t-il ? Ce sont principalement ces questions que nous examinons à partir d’exemples pris dans l’étude des mathématiques, et leur examen nous permet de mettre en évidence une manifestation de la contrainte du refoulement du didactique au cœur même travail des didacticiens.
The Ontogenetic Development Prerequisites of Physical Activities in the Aquatic Environment in Early Childhood
Authors: Nováková Tereza , Čechovská Irena 
Published: June 2019

Summary
The text deals with neurophysiological and kinesiological developmental principles associated with the early development of young children as the fundamental prerequisites for physical education in the aquatic environment. Swimming in infancy and early childhood using the developmental principles and understanding of individual variability represent enormous potential to create a positive attitude of the child to exercise in aquatic environments. We believe that the experience with these basic tasks can play a key role in future exercise habits and swimming literacy of the individual. Parents attending infant swimming courses led by an instructor acquire practical skills and deeper insight into principles of their child's motor learning. All activities in the aquatic environment at an early age should allow transfer of child’s experiences to preswimming education and result in full swimming literacy.
Developing Expertise in Sport Coaching Through Engagement with Disability Programmes
Authors: Crisp Philippe 
Published: June 2019

Summary
Numerous academic and practitioner research has examined the role of Higher Education Institutions (HEI) in the development of sport coaches in the UK (e.g. Crisp 2018; Stoszkowski and Collins 2018). However, whilst most fields related to coach development have significant bodies of work underpinning them, there is a dearth of information related to best practice within the context of disability sport coaching. Given that both coach learning in the HEI context and disability sports coaching are significant areas worthy of further exploration, this work investigates how learning can be developed through disability sport coaching in the HEI context. The aims of this study were to gather the perceptions, thoughts, and experiences of ten student-coaches enrolled on an HEI coaching programme who were completing a year long placement module that included sessions for participants with disabilities. Data were collected through two focus group meetings with the student-coaches and the submission of learning journals. Inductive analysis showed that coaching disability groups facilitated learning through generating knowledge from practice through a process of reflection, higher order thinking, and meta-cognition. This suggests that using disability coaching can be a useful tool for HEIs to use in terms of challenging student-coach practice and education.