bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemoradiation therapy induces in vivo changes in gene promoter methylation & gene transcript expression in patients with invasive cervical cancer
Authors: Sood Swati , Patel Firuza D. , Srinivasan Radhika , Dhaliwal Lakhbir K. 
Published: May 2018

Background & objectives:
Invasive cervical cancer patients are primarily treated with chemoradiation therapy. The overall and disease-free survival in these patients is variable and depends on the tumoral response apart from the tumour stage. This study was undertaken to assess whether in vivo changes in gene promoter methylation and transcript expression in invasive cervical cancer were induced by chemoradiation. Hence, paired pre- and post-treatment biopsy samples were evaluated for in vivo changes in promoter methylation and transcript expression of 10 genes (ESR1, BRCA1, RASSF1A, MYOD1, MLH1, hTERT, MGMT, DAPK1, BAX and BCL2L1) in response to chemoradiation therapy.

Methods:
In patients with locally advanced invasive cervical cancer, paired pre- and post-treatment biopsies after 10 Gy chemoradiation were obtained. DNA/RNA was extracted and gene promoter methylation status was evaluated by custom-synthesized methylation PCR arrays, and the corresponding gene transcript expression was determined by absolute quantification method using quantitative reverse transcription PCR.

Results:
Changes in the gene promoter methylation as well as gene expression following chemoradiation therapy were observed. BAX promoter methylation showed a significant increase (P< 0.01) following treatment. There was a significant increase in the gene transcript expression of BRCA1 (P< 0.01), DAPK1 and ESR1 (P< 0.05), whereas MYOD1 and MLH1 gene transcript expression was significantly decreased (P< 0.05) following treatment.

Interpretation & conclusions:
The findings of our study show that chemoradiation therapy can induce epigenetic alterations as well as affect gene expression in tissues of invasive cervical cancer which may have implications in determining radiation response.
Assessment of potential biomarkers of atherosclerosis in Indian patients with type 2 diabetes mellitus
Authors: Kulkarni Namrata Bindurao , Ganu Meghana Ulhas , Godbole Sanjay Ganpati , Deo Sudha S. 
Published: May 2018

Background & objectives:
Various biological markers of subclinical atherosclerosis have been proposed to predict cardiovascular events in patients with diabetes mellitus (DM). However, there are only a few clinical studies assessing the role of invasive biomarkers [CD-36, peroxisome proliferator-activated receptor gamma (PPAR-γ) and YKL-40] in Indian patients with type 2 DM (T2DM). Hence, the present study was conducted to assess protein levels and gene expression of CD-36, PPAR-γ and YKL-40 in patients with T2DM and compare that with hypertensive and healthy controls.

Methods:
All the participants were subjected to medical history, anthropometric measurements and biochemical and biomarker (ELISA and real-time polymerase chain reaction) estimations. The study groups consisted of patients with T2DM (>5 yr) with hypertension (n=55), patients with T2DM (<2 yr) without hypertension (n=28), hypertensive controls (n=31) and healthy controls (n=30).

Results:
Gene expressions of YKL-40 and CD36 were significantly higher in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P=0.006). In addition, a significant increase in serum levels of sCD36, PPAR-γ and YKL-40 was observed in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P< 0.05). Serum levels as well as gene expression of CD36 showed significant correlation with serum levels as well as gene expression of PPAR-γ (ρ=0.45 and ρ=0.51; P< 0.001), respectively.

Interpretation & conclusions:
CD36 and YKL-40 may be potential inflammatory biomarkers for early onset of atherosclerosis in patients with T2DM.
A CR Analogue of Yau’s Conjecture on Pseudoharmonic Functions of Polynomial Growth
Authors: Chang Der-Chen , Chang Shu-Cheng , Han Yingbo , Tie Jingzhi 
Published: May 2018

AbstractIn this paper, we first derive the CR volume doubling property, CR Sobolev inequality, and the mean value inequality. We then apply them to prove the CR analogue of Yau’s conjecture on the space consisting of all pseudoharmonic functions of polynomial growth of degree at most$d$in a complete noncompact pseudohermitian$(2n+1)$-manifold. As a by-product, we obtain the CR analogue of the volume growth estimate and the Gromov precompactness theorem.
Barclay Fowell Buxton, Japanese Christians, and the Japan Evangelistic Band
Authors: Bundy David D. , Fujii Masaya 
Published: May 2018

ABSTRACT
Barclay Fowell Buxton, a missionary in Japan from 1890 to 1903, was appointed by the Church Missionary Society by special arrangement as an independent missionary. When Alphaeus Paget Wilkes joined him in Japan (1897), they organized (1903) the Japan Evangelistic Band (日本伝道隊, Nihon Dendōtai). Buxton attracted young Japanese people wanting to learn his spirituality, theology, and approach to evangelism. This network made important contributions to Japanese Christianities, as his friends and disciples adapted and promoted these understandings. Building on the work of Miyakoda, Kudō Hiroo, Mullins, Bebbington, Randall, and Bundy, this essay examines the religious orientation of Buxton in the British Radical Holiness movements, as well of his Japanese disciples and colleagues. It argues that the locus of the significant continuities between Buxton and his Japanese colleagues was in the Radical Holiness movements in the United Kingdom.
PERFIL DE GESTANTES CARDIOPATAS: ALTO RISCO
Authors: FELCZAK Cláudia , Ravelli Ana Paula Xavier , Skupien Suellen Vienscoski , Ricken Maria Helena , Dalazoana Bayer Laryssa De Col , Almeida Eva Aparecida de 
Published: May 2018

Objetivo: caracterizar as gestantes cardiopatas com alto risco gestacional atendidas no setor secundário pela 3ª regional de saúde do Paraná. Método: pesquisa quantitativa, documental eretrospectiva,realizada entre julho e agosto de 2016. O estudo apropriou-se de dados secundários, de indicadores de saúde advindos do Ambulatório de Alto Risco Gestacional dos Campos Gerais. O banco de dados compreendeu outubro de 2013 a junho de 2016, sendo analisados 60 prontuários de gestantes cardiopatas, utilizando para tal as variáveis: diagnóstico cardíaco, e fatores sociodemográficos e antecedentes obstétricos. Resultados: predominou-se a arritmia cardíaca como diagnóstico encontrado nos prontuários, a Hipertensão Arterial Sistêmica como fator de risco cardiovascular, pacientes procedentesda cidade de Castro, com idade média de 26,4 anos, casadas,com ensino fundamental completo e multigestas. Conclusão: conclui-se que estas gestantes apresentaram a arritmia cardíaca como principal diagnóstico. Issoeleva os índices de cesariana, sendo primordial a atuação do enfermeiro no pré-natal para minimizar possíveis complicações.
O design centrado no usuário: os projetos web para micro e pequenas empresas da América do Sul
Authors: Aranda Miguel Angel Delgado , Pinto José Simão de Paula 
Published: May 2018

Introdução: as técnicas e metodologias de desenvolvimento web mudam e evoluem com o percorrer do tempo, desde conceitos dinâmicos até colaborativos formam parte da variedade das novas tendências web; setores empresariais de pequeno porte devem-se adequar às novas tecnologias da informação para uma melhoria e apoio das suas estratégias. Objetivos: o objetivo deste trabalho é delinear o método do design centrado no usuário nos projetos web orientados a micro e pequenas empresas incidindo nos conceitos de usabilidade e arquitetura da informação, sem esquecer as características próprias das empresas de pequeno porte e a sua situação na America do Sul.Metodologia: a metodologia utilizada para o desenvolvimento deste trabalho esta baseada numa revisão bibliográfica e documentalResultados: o design centrado no usuário pode ser adotado no desenvolvimento web para apoio estratégico nas micro e pequenas empresas da America do Sul.Conclusões: as novas tecnologias da informação têm muitas deficiências de aplicação nas empresas da America do Sul, que vem acompanhadas por políticas publicas pouco objetivas com serias deficiências estruturais nos países sob desenvolvidos dessa região, pelo que técnicas as técnicas de desenvolvimento web não são bem utilizadas nem aproveitadas pelas pessoas e pelas micro e pequenas empresas.
A fotografia como documento: com a palavra Otlet e Briet
Authors: Tonello Izângela Maria Sansoni , Madio Telma Campanha de Carvalho 
Published: May 2018

Introdução: A quantidade e variedade de informações que veiculam em diferentes suportes e meios incitam uma preocupação, em especial, em relação aos documentos fotográficos, já que se constituem atualmente foco de interesse da área da Ciência da Informação. Nesse contexto, destacam-se as fotografias como fontes de informações geradoras de conhecimento e também como importante subsídio para pesquisa nas diferentes áreas. Objetivo: Consistiu em pesquisar os conceitos e definições que embasam a fotografia como documento em unidades de informação. Metodologia: Realizou-se uma pesquisa bibliográfica na literatura nacional e internacional, principalmente com base em Paul Otlet e Suzanne Briet. Resultados e conclusões: Pode-se afirmar mediante os significados acerca do termo documento, discorridas na literatura pelos autores acima, que a fotografia corresponde aos pressupostos necessários para consubstanciar documento e fotografia em documento fotográfico.
O “Madre Benícia” nas memórias de uma professora: o álbum de recordações de Cléris Becker
Authors: Souza José Edimar 
Published: May 2018

A pesquisa aborda aspectos da história do atual Instituto Estadual Madre Benícia, situada no bairro rural Lomba Grande, município gaúcho de Novo Hamburgo. A região é conhecida por ter acolhido, desde o início do século XIX os primeiros imigrantes alemães que chegaram ao Rio Grande do Sul. Nesse sentido, o culto evangélico desses imigrantes contribuiu para instalação da Igreja/escola neste lugar. E este aspecto contribuiu para as práticas de escolarização desenvolvidas na localidade. Sob a ótica da história cultural e valendo-se de documentos e a metodologia da história oral, especialmente aquelas produzidas a partir da entrevista com a professora Cléris Allgayer Becker o objetivo deste trabalho foi conhecer e compreender elementos da constituição desta instituição, sobretudo evidenciando o processo de instalação do Grupo Escolar neste lugar. Destaca-se a temporalidade de 1940, ocasião em que é implantado o Grupo Escolar de Lomba Grande e 1969 por ocasião da inaugurado do prédio próprio. Os registros no álbum evidenciam o modo como produzimos memórias diante da realidade na qual os sujeitos estão inseridos e envolvidos com suas trajetórias de vida e profissional. Além disso, a organização e mobilização dos professores e dos moradores do lugar demonstram que a escolarização fora um dos aspectos que sempre esteve entre as prioridades dessa comunidade.
A responsabilidade social do ensino de História
Authors: Angelotti Carmo Maria Andréa 
Published: May 2018

Resenha da obra: MAIA, Tatyana de Amaral; ALVES, Luís Alberto Marques; HERMETO, Miriam; RIBEIRO, Cláudia Sofia Pinto (ORG). (Re)Construindo o passado: o papel insubstituível do ensino da História. Porto Alegre: EdiPUCRS; Porto: CITCEM, 2016, 286p.
Enkele beschouwingen naar aanleiding van diverse recente Europese en Nederlandse uitspraken in het internationaal arbeidsrecht (Koelzsch, Voogsgeerd, Vicoplus, Nuon-rechtspraak en zaak FNV/De Mooij). Welke (nieuwe) argumentatiemogelijkheden voor werknemers tot opeisen van (meer) arbeidsrechtelijke bescherming in internationale situaties?
Authors: Van Den Eeckhout Veerle 
Published: May 2018

Analysis of recent European and Dutch case-law, dealing with issues of applicable law of international labour contracts
Recent hebben zowel het Hof van Justitie als meerdere Nederlandse rechters zich in enkele opmerkelijke zaken uitgesproken over het op een internationale arbeidsovereenkomst toepasselijke arbeidsrecht. In de zaken Koelzsch en Voogsgeerd heeft het Hof van Justitie voor het eerst artikel 6 EVO-verdrag uitgelegd. Door Nederlandse rechters zijn ophefmakende uitspraken gedaan, zowel inzake toepasselijkheid van artikel 6 Buitengewoon Besluit Arbeidsverhoudingen als inzake toepasselijkheid van een Nederlandse CAO op naar Nederland uitgezonden werknemers.Bovendien heeft het Hof van Justitie zich in de zaak Vicoplus uitgesproken over een zaak die zich afspeelde in een context van internationale detachering en die mogelijk consequenties inhoudt voor het internationaal arbeidsrecht. In deze bijdrage worden deze onderscheiden uitspraken geanalyseerd vanuit de volgende invalshoek: welke argumentatiemogelijkheden kunnen deze uitspraken bieden aan werknemers die pogen (meer) arbeidsbescherming op te eisen indien hun rechtsverhouding zich in internationale context afspeelt? In deze analyse wordt ook aandacht gegeven aan de mate waarin de uitspraken kunnen worden begrepen als zouden zij iets hebben veranderd aan de vermeende “status quo” van het internationaal arbeidsrecht na de ophefmakende zaken Viking, Laval, Rüffert en C./Luxemburg.
Personhood and legal status: reflections on the democratic rights of corporations
Authors: Beckman Ludvig 
Published: May 2018

Personhood and legal status: reflections on the democratic rights of corporations
Corporations can have rights but whether they should also have democratic rights depends among other things on whether they are the kind of entities to which the democratic ideal applies. This paper distinguishes four different conceptions of “the person” that can have democratic rights. According to one view, the only necessary condition is legal personality, whereas according to the other three views, democratic inclusion is conditioned also by personhood in the natural sense of the term. Though it is uncontroversial that corporations can be legal persons, it is plausible to ascribe personhood in the natural sense to corporations only if personhood is conceptualized exclusively in terms of moral agency. The conclusion of the paper is that corporations can meet the necessary conditions for democratic inclusion but that it is not yet clear in democratic theory exactly what these conditions are.
Les limites de l’évaluation économique de la biodiversité
Authors: Maris Virginie , Revéret Jean-Pierre 
Published: May 2018

Devant le constat du déclin toujours plus rapide de la diversité biologique et les limites des ressources disponibles pour l’enrayer, il est nécessaire de déterminer quels moyens devraient être engagés dans sa protection. Pour ce faire, une méthode efficace serait d’évaluer les bénéfices tirés de la biodiversité afin d’estimer rationnellement les coûts légitimes de sa protection. L’évaluation économique, qui se présente d’emblée sur un mode quantitatif, serait alors un outil précieux. Dans ce texte, nous présentons différentes méthodes d’évaluation économique de la biodiversité ainsi que certaines de leurs limites méthodologiques. Par la suite, nous montrons qu’en dépit de ses avantages pratiques, l’évaluation économique échoue à représenter l’ensemble des valeurs en jeu dans la protection de la biodiversité. Nous décrivons alors trois types de valeurs incommensurables avec des bénéfices économiques : la valeur de legs, qui renvoie aux obligations de transmission du patrimoine naturel dont nous avons hérité ; la valeur d’existence, qui renvoie à la considération morale d’intérêts autres que ceux des êtres humains ; la valeur de transformation, qui renvoie à la capacité d’examiner et de critiquer nos préférences et inclinaisons afin d’inclure celles-ci dans une vision du monde rationnelle et cohérente. Pour conclure, nous plaidons en faveur de l’élaboration de méthodes de concertation et d’évaluation participatives et pluralistes permettant de rendre compte de la diversité et de l’hétérogénéité des valeurs de la biodiversité.
Développement durable : quelques points litigieux
Authors: Larrère Catherine 
Published: May 2018

Le développement durable a pour objectif de concilier des exigences diverses, sinon antagoniques : l’économique, le social, l’environnemental. On peut donc se demander s’il répond vraiment aux intuitions qui sont au point de départ de la conscience écologique. Nous en dégageons trois, dans trois domaines : l’exigence de protection de la nature, la conviction que la solution à la crise environnementale ne peut pas être purement technique, et l’insistance sur la dimension sociale, et pas seulement naturelle, de la crise environnementale. Chacune de ces exigences donne lieu à des débats conflictuels : préservation contre conservation, souci éthique contre optimisme technologique, exigence sociale et politique contre traitement scientiste des questions environnementales. De l’examen de ces litiges, il ressort que l’avenir du développement durable passe par une reformulation du concept de nature.
A survey on sleep assessment methods
Authors: Ibáñez Vanessa , Silva Josep , Cauli Omar 
Published: May 2018

PurposeA literature review is presented that aims to summarize and compare current methods to evaluate sleep.MethodsCurrent sleep assessment methods have been classified according to different criteria; e.g., objective (polysomnography, actigraphy…) vs. subjective (sleep questionnaires, diaries…), contact vs. contactless devices, and need for medical assistance vs. self-assessment. A comparison of validation studies is carried out for each method, identifying their sensitivity and specificity reported in the literature. Finally, the state of the market has also been reviewed with respect to customers’ opinions about current sleep apps.ResultsA taxonomy that classifies the sleep detection methods. A description of each method that includes the tendencies of their underlying technologies analyzed in accordance with the literature. A comparison in terms of precision of existing validation studies and reports.DiscussionIn order of accuracy, sleep detection methods may be arranged as follows:Questionnaire < Sleep diary < Contactless devices < Contact devices < PolysomnographyA literature review suggests that current subjective methods present a sensitivity between 73% and 97.7%, while their specificity ranges in the interval 50%–96%. Objective methods such as actigraphy present a sensibility higher than 90%. However, their specificity is low compared to their sensitivity, being one of the limitations of such technology. Moreover, there are other factors, such as the patient’s perception of her or his sleep, that can be provided only by subjective methods. Therefore, sleep detection methods should be combined to produce a synergy between objective and subjective methods. The review of the market indicates the most valued sleep apps, but it also identifies problems and gaps, e.g., many hardware devices have not been validated and (especially software apps) should be studied before their clinical use.
APLICAÇÃO DA TÉCNICA DE ELETROCOAGULAÇÃO PARA A REMOÇÃO DA CORANTE TÊXTIL
Authors: Algeri Alessandra , Vaghetti Luchese Augusto , Mendes Morini Pamella , Sehn Elizandra 
Published: May 2018

O objetivo deste trabalho consistiu em determinar o tempo operacional e a densidade de corrente elétrica que otimizassem a remoção da cor de um efluente sintético à base de corante vermelho reativo, por Delineamento Composto Central Rotacional (DCCR). A partir das condições otimizadas foi realizada uma análise de custos operacionais em função da energia gasta e também do consumo de eletrodo. As condições ótimas e os custos operacionais foram determinados para os comprimentos de onda de 515 e 543 nm. A região ótima de remoção, para os dois comprimentos de onda, ficou entre 47 e 51,1 minutos e 360-440 A m-2, com valores teóricos de remoção estimados entre 70 e 80%. O consumo de eletrodos e de energia nos tempos e densidade de correntes otimizados encontrados ficou em 1,71 g L-1 e 0,0077 Wh m-3para o comprimento de onda de 515 nm e 1,73 g L-1 e 0,0073 Wh m-3 para o de 543 nm, resultando nas equações: , para o comprimento de 515 nm e para o 543 nm, nos quais a corresponde ao custo de energia (em R$.kWh-1) e b ao custo mássico da placa (em R$.kg eletrodo-1).
Command governor‐based adaptive control for dynamical systems with matched and unmatched uncertainties
Authors: Yayla Metehan , Arabi Ehsan , Kutay Ali Turker , Yucelen Tansel 
Published: May 2018

SummaryIn this paper, we propose a command governor‐based adaptive control architecture for stabilizing uncertain dynamical systems with not only matched but also unmatched uncertainties and achieving the desired command following performance of a user‐defined subset of the accessible states. In our proposed solution, online least‐squares solutions for the matched and unmatched parameters are obtained through integration method and they are employed in the adaptive control framework. Specifically, the matched uncertainty is identified and its effect upon the system behavior is entirely attenuated. Moreover, using the unmatched uncertainty approximation obtained through radial basis function neural networks, the command governor signal is designed to achieve the desired command following performance of the user‐defined subset of the accessible states. With this command governor‐based model reference adaptive control architecture, the tracking error of the selected states can be made arbitrarily small by judiciously tuning the design parameters. In addition to the analysis of the closed‐loop system stability using methods from the Lyapunov theory, our findings are also illustrated through numerical examples.
Flexible All‐Solid‐State Supercapacitors of High Areal Capacitance Enabled by Porous Graphite Foams with Diverging Microtubes
Authors: Li Weigu , Tekell Marshall C. , Liu Chang , Hethcock Jacob A. , Fan Donglei 
Published: May 2018

AbstractThe practical applications of wearable electronics rely on the successful development of flexible and integrable energy devices with small footprints. This work reports a completely new type of graphite foam made of strategically created superstructures with covalently attached diverging microtubes, and their applications as electrode supports for binder‐free and additive‐free flexible supercapacitors. Because of the enhanced volumetric surface areas compared to conventional graphite foams, a high loading of pseudocapacitive materials (Mn3O4, 3.91 mg cm−2, 78 wt%) is achieved. The supercapacitors provide areal capacitances as high as 820 mF cm−2 at 1 mV s−1, while still maintaining high rate capability and 88% retention of capacitance after 3000 continuous charging and discharging cycles. When assembled as all‐solid‐state flexible symmetric supercapacitors, they offer one of the highest full‐cell capacitances (191 mF cm−2) among similar manganese oxide/graphene foams, and retain 80% capacitance after 1000 mechanical cycles. The potential of such flexible supercapacitors is also manifested by directly powering electric nanomotors that can trace along letters “U” and T,” which is the first demonstration of flexible supercapacitors for wireless/portable nanomanipulation systems. This work could inspire a new paradigm in designing and creating 3D porous micro/nanosuperstructures for an array of self‐powered electronic and nanomechanical applications.