bluuebunny/crossref_metadata_2025_split huggingface dataset:
Service load balancing, scheduling, and logistics optimization in cloud manufacturing by using genetic algorithm
Authors: Jafarnejad Ghomi Einollah , Rahmani Amir Masood , Qader Nooruldeen Nasih 
Published: May 2019

SummaryRecent years have seen a great deal of attention in the aspects of cloud manufacturing. Generally, in cloud manufacturing, the capabilities and manufacturing resources that distributed in different geographical places are virtualized and encapsulated into manufacturing cloud services. The literature confirms that applying queuing theory to optimize service selection and scheduling load balancing (SOSL) while taking into account logistics is still scarce and an open issue for practical implementation of cloud manufacturing. This reason motivates our attempts to present a cloud manufacturing queuing system (CMfgQS) as well as a load balancing heuristic algorithm based on task process times (LBPT), simultaneously among the first studies in this research area. Hence, a novel optimization model as mixed‐integer linear programming is developed by implementing both CMfgQs and LBPT. Due to the natural complexity of the problem proposed, this study applies a genetic algorithm to solve the developed optimization model in large instances. Finally, the computational results ensure the effectiveness of the proposed model as well as the performance of the employed heuristic algorithm.
Sustainable Knowledge‐Driven Approaches in Transition‐Metal‐Catalyzed Transformations
Authors: Sanjosé‐Orduna Jesús , Mudarra Ángel L. , Martínez de Salinas Sara , Pérez‐Temprano Mónica H. 
Published: May 2019

AbstractThe sustainable synthesis of relevant scaffolds for their use in the pharmaceutical, agrochemical, and materials sectors constitutes one of the most urgent challenges that the chemical community needs to overcome. In this context, the development of innovative and more efficient catalytic processes based on a fundamental understanding of the underlying reaction mechanisms remains a largely unresolved challenge for academic and industrial chemists. Herein, selected examples of computational and experimental knowledge‐driven approaches for the rational design of transition‐metal‐catalyzed transformations are discussed.
Quantum chemistry computing for terahertz spectra of fatty acid ester
Authors: Kato Masamichi , Matsumoto Satoshi 
Published: May 2019

AbstractQuantum chemistry computing is applied to estimate the Terahertz spectra of Fatty Acid Ester, which has group vibrations caused by intermolecular interactions, three‐dimensional structure of substances, and so on. The conformation and distribution of the molecule are very important to predict terahertz absorption spectra. Since ester oil consists of various molecular structures, Boltzmann statics is proposed to estimate the group vibration spectra in the paper. Measured spectrum approximately coincides with the simulation results. This method will be widely applicable to estimate the terahertz absorption properties.
Malondialdehyde, 4‐Hydroxy‐2‐Hexenal, and 4‐Hydroxy‐2‐Nonenal in Vegetable Oils: Formation Kinetics and Application as Oxidation Indicators
Authors: Ma Lukai , Liu Guoqin , Liu Xinqi 
Published: May 2019

The formation of three toxic reactive aldehydes, malondialdehyde (MDA), 4‐hydroxy‐hexenal (HHE), and 4‐hydroxy‐2‐nonenal (HNE), is investigated in five commonly consumed vegetable oils using a method based on the Schaal oven test. HHE is only detected in linseed oil (LO) and rapeseed oil (RO), while MDA and HNE are found to be present in all tested oils. The formation potential of MDA, HHE, and HNE in the tested oils is closely related to the initial polyunsaturated fatty acid (PUFA) content in the oil. Correlation analyses reveal low correlation coefficients for MDA, determining its unsuitability to evaluate the oxidation of oils with low PUFA content, such as palm oil and camellia oil; in contrast, HHE and HNE show sufficient correlations with other oxidation indices in all tested oils. Furthermore, regression analysis indicates that HHE content can predict the oxidation of ω‐3 type oil, while HNE content can estimate oxidative deterioration of ω‐6 type oils. Particularly, HNE content can also evaluate the oxidation of ω‐9 type oils such as PO and CLO with relatively low PUFA level for the high correlations (>0.991, P < 0.01) toward the total oxidation value (TOTOX).Practical Applications: Edible oil consumption continues to increase worldwide. Therefore, it is very important to understand the conditions under which potentially health‐damaging compounds are formed in these oils and to develop methods to inhibit their formation or eliminate them from the oils. This study investigates the formation of three toxically reactive aldehydes, namely MDA, HHE, and HNE, through lipid oxidation, specifically PUFA peroxidation. The application of these aldehydes as oxidation indicators for different vegetable oils is also explored. This work could prove beneficial for the quality control of vegetable oils in the edible oil industry.The formation of three toxic aldehydes, MDA, HHE, and HNE in different types of vegetable oils is investigated. Considerable amounts of MDA, HHE, and HNE is found in all the tested oils. The results show the formation of these three aldehydes is competitive. Besides, MDA content is not appropriate to evaluate the oxidation of oils with low PUFA content, such as PO and CLO; while HHE and HNE can characteristically depict the oxidation of ω‐3 and ω‐6 type oil.
Forecasting and nowcasting emerging market GDP growth rates: The role of latent global economic policy uncertainty and macroeconomic data surprise factors
Authors: Cepni Oguzhan , Guney I. Ethem , Swanson Norman R. 
Published: May 2019

AbstractIn this paper, we assess the predictive content of latent economic policy uncertainty and data surprise factors for forecasting and nowcasting gross domestic product (GDP) using factor‐type econometric models. Our analysis focuses on five emerging market economies: Brazil, Indonesia, Mexico, South Africa, and Turkey; and we carry out a forecasting horse race in which predictions from various different models are compared. These models may (or may not) contain latent uncertainty and surprise factors constructed using both local and global economic datasets. The set of models that we examine in our experiments includes both simple benchmark linear econometric models as well as dynamic factor models that are estimated using a variety of frequentist and Bayesian data shrinkage methods based on the least absolute shrinkage operator (LASSO). We find that the inclusion of our new uncertainty and surprise factors leads to superior predictions of GDP growth, particularly when these latent factors are constructed using Bayesian variants of the LASSO. Overall, our findings point to the importance of spillover effects from global uncertainty and data surprises, when predicting GDP growth in emerging market economies.
Functional remodeling of an electrospun polydimethylsiloxane‐based polyether urethane external vein graft support device in an ovine model
Authors: El‐Kurdi Mohammed , Soletti Lorenzo , McGrath Jonathan , Linhares Stephen , Rousselle Serge , Greisler Howard , Edelman Elazer , Schoen Frederick J. 
Published: May 2019

AbstractSaphenous vein graft (SVG) failure rates are unacceptably high, and external mechanical support may improve patency. We studied the histologic remodeling of a conformal, electrospun, polydimethylsiloxane‐based polyether urethane external support device for SVGs and evaluated graft structural evolution in adult sheep to 2 years. All sheep (N = 19) survived to their intended timepoints, and angiography showed device‐treated SVG geometric stability over time (30, 90, 180, 365, or 730 days), with an aggregated graft patency rate of 92%. There was minimal inflammation associated with the device material at all timepoints. By 180 days, treated SVG remodeling was characterized by minimal/nonprogressive intimal hyperplasia; polymer fragmentation and integration; as well as the development of a neointima, and a confluent endothelium. By 1‐year, the graft developed a media‐like layer by remodeling the neointima, and elastic fibers formed well‐defined structures that subtended the neo‐medial layer of the remodeled SVG. Immunohistochemistry showed that this neo‐media was populated with smooth muscle cells, and the intima was lined with endothelial cells. These data suggest that treated SVGs were structurally remodeled by 180 days, and developed arterial‐like features by 1 year, which continued to mature to 2 years. Device‐treated SVGs remodeled into arterial‐like conduits with stable long‐term performance as arterial grafts in adult sheep.
Pyridine derivatives as anticancer lead compounds with Fatty Acid Synthase as the target: An in silico‐guided in vitro study
Authors: Amrutha Nisthul A. , Archana P. Retnakumari , Mohan Shankar G. , Anto Ruby John , Sadasivan C. 
Published: May 2019

AbstractFor the past few decades, structure‐based drug discovery (SBDD) has become an inevitable technique in the drug development process for screening hit compounds against therapeutic targets. Here, we have successfully used the SBDD approach viz. virtual high‐throughput screening to identify potential inhibitors against the Ketoacyl synthase (KS) domain of Fatty acid synthase (FASN). Overexpression of FASN, and subsequent enhancement of de novo lipogenesis is a key survival strategy of cancer cells. Hence, targeting lipid metabolism using FASN inhibitors has been considered as a promising method to induce metabolic stress, thereby posing a survival disadvantage to cancer cells. In the present study, we have successfully identified eight FASN inhibitors from Asinex Elite database by implementing in silico tools. Five of the hit compounds share a common ring structure, which enables characteristic binding interactions with FASN‐KS. Among them, in vitro validation showed that SFA 22637550 possesses significant FASN inhibitory activity and antiproliferative effect in human cancer cells of various origins. The maximum sensitivity was exhibited towards HepG2 hepatocellular carcinoma cells (IC50 = 28 µM). The mode of cell death was found to be apoptosis with a significant increase in SubG0 population without affecting any other phases of the cell cycle. The current study puts forward an excellent core structure for the development of potent FASN inhibitors for successfully targeting cancer cell metabolism, thereby causing selective cell death.
Fe3O4@SiO2@sulfated boric acid as superparamagnetic and recyclable nanocatalyst‐assisted, one‐pot,pseudofour‐component synthesis of 5‐amino‐2‐aryl‐3H‐chromeno[4,3,2‐de][1,6]naphthyridine‐4‐carbonitrile derivatives
Authors: Khosravi Zeynab , Mohammadi Hadi , Shaterian Hamid Reza 
Published: May 2019

AbstractThe catalytic performance of the superparamagnetic nanocatalyst Fe3O4@SiO2@Sulfated boric acid as a green, recyclable, and acidic solid catalyst in the synthesis of chromeno[4,3,2‐de][1,6]naphthyridine derivatives has been studied. Chromeno[4,3,2‐de][1,6]naphthyridine derivatives via apseudofour‐component reaction from aromatic aldehydes (1 mmol), malononitrile (2 mmol), and 2′‐hydroxyacetophenone in the presence of Fe3O4@SiO2@Sulfated boric acid (0.004 g) as a nanocatalyst in 3 mL of water as a green solvent at 80°C has been synthesized. The advantages of this method are higher product yields in shorter reaction times, easy recyclability and reusability of the catalyst, and easy work‐up procedures. The nanocatalyst was reused at least six times. The nanocatalyst retained its stability in the reaction, and after reusability, it was separated easily from the reaction by an external magnet.
BANOVA: Bayesian Analysis of Experiments in Consumer Psychology
Authors: Wedel Michel , Dong Chen 
Published: May 2019

This article introduces a Bayesian extension of ANOVA for the analysis of experimental data in consumer psychology. The approach, called BANOVA (Bayesian ANOVA), addresses some common challenges that consumer psychologists encounter in their experimental work, and is specifically suited for the analysis of repeated measures designs. There appears to be a recent surge in interest in those designs based on the recognition that they are sensitive to individual differences in response to experimental treatments and that they offer advantages for assessing causal mediating mechanisms, even at the individual level. BANOVA enables the analysis of repeated measures data derived from mixed within–between‐subjects experiments with Normal and nonNormal‐dependent variables and accommodates unobserved individual differences. It allows for the calculation of effect sizes, planned comparisons, simple effects, spotlight and floodlight analyses, and includes a wide range of mediation, moderation, and moderated mediation analyses. An R software package implements these analyses, and aims to provide a one‐stop shop for the analysis of experiments in consumer psychology. The package is illustrated through applications to a number of data sets from previously published studies.
Observing the Effects of Temperature and Surface Roughness on Cetyltrimethylammonium Bromide Adsorption Using a Quartz‐Crystal Microbalance with Dissipation Monitoring
Authors: Hamon Joshua J. , Striolo Alberto , Grady Brian P. 
Published: May 2019

AbstractThe effects of temperature and surface roughness on the mass and viscoelasticity of an adsorbed surfactant layer were monitored using a quartz crystal microbalance with dissipation monitoring (QCM‐D). Adsorption isotherms at 30, 40, 50, and 60 °C and at two different roughnesses on gold were measured for cetyltrimethylammonium bromide (CTAB). All isotherms displayed an increase in mass and dissipation as surfactant concentration was increased to its critical micelle concentration (CMC). Above the CMC, adsorption reached a peak followed by a slight decrease to a plateau at the equilibrium adsorption value. As the temperature was increased, the adsorbed mass above the CMC decreased. The adsorbed mass decreased further by increasing substrate roughness, while the dissipation remained unchanged within experimental uncertainty. Dynamic adsorption experiments were also conducted at various temperatures for select concentrations above and below the CMC, providing evidence for the importance of different adsorption mechanisms as a function of both surfactant concentration and surface roughness.
Does gender matter for hotel performance? Evidence from the Italian hospitality industry
Authors: Menicucci Elisa , Paolucci Guido , Paoloni Niccolò 
Published: May 2019

AbstractThe purpose of this paper is to explore the relationship between gender and profitability in the Italian hospitality industry during the period 2008–2017. The study examines whether female executive managers have any significant effect on the performance of hotel firms. Gender differences result in female underperformance when performance is measured by firm size. Within a bivariate model, findings show few differences when growth and profitability are compared by gender. When a regression model is designed to control other performance determinants (demographic, financial, and family variables), women‐managed hotels outperform those managed by men for hotel growth.
Trimethylamine N‐Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease
Authors: Tan Xuying , Liu Yan , Long Jingan , Chen Si , Liao Gongcheng , Wu Shangling , Li Chunlei , Wang Lijun , Ling Wenhua , Zhu Huilian 
Published: May 2019

ScopeTrimethylamine N‐oxide (TMAO), the metabolite of choline generated by gut microbiota, is associated with nonalcoholic fatty liver disease (NAFLD) and could influence bile acid (BA) metabolism. However, whether TMAO aggravates liver steatosis by modulating BA metabolism and the related mechanisms has not been investigated.Methods and resultsA case‐control study including biopsy‐proven NAFLD patients (n = 34) and controls (n = 14) is conducted to determine the correlation between TMAO and BA metabolism. Serum levels of total BA and the percentage of farnesoid X receptor (FXR)‐antagonistic BA species are markedly higher in NAFLD patients than in the controls. Serum levels of TMAO positively correlated with the serum levels of total BA and hepatic mRNA expression of cholesterol 7 alpha hydroxylase (CYP7A1). In a murine model, it is found that 18 weeks administration of TMAO impairs liver function and increases hepatic triglyceride accumulation and lipogenesis in mice fed with a high‐fat diet. TMAO increases BA synthesis and shifted hepatic BA composition toward FXR‐antagonistic activity. Knockdown of CYP7A1 via small interfering RNA or activation of FXR by GW4064 blocks the effect of TMAO‐induced lipogenesis in palmitic acid‐treated HepG2 cells.ConclusionTMAO aggravates liver steatosis by suppressing BA‐mediated hepatic FXR signaling.
A compact dual‐band implantable antenna for medical telemetry
Authors: Yeap Kimho , Voon Chowshen , Hiraguri Takefumi , Nisar Humaira 
Published: May 2019

AbstractWe present the design of a planar, low‐profile dual‐band implantable antenna which operates in the 402‐ to 405‐MHz Medical Implant Communication Service (MICS) and the 2.4‐ to 2.5‐GHz Industrial, Scientific, and Medical (ISM) bands. The designed antenna was experimentally validated by implanting it first into a synthetic human skin tissue phantom and then a minced pork model. The measurement results show that the antenna has 10‐dB impedance bandwidths of at least 120 MHz which covers the MICS band and at least 40 MHz which covers the ISM band. The proposed antenna is printed on an RO3210 substrate and it occupies a compact volume of 22 mm × 16 mm × 1.27 mm. The average SAR values at the center frequency of both bands, that is, 403.5 MHz and 2.45 GHz are, respectively, below 0.352 and 0.054 μW/kg. Both values are far below the limits stipulated by the IEEE C95.1‐1999 (ie, 1.6 W/kg) and IEEE C95.1‐2005 (ie, 2 W/kg) standards. The simulated and measured performance of the antenna confirms its good radiation characteristics.
Single‐cell RNA‐seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis
Authors: Zhou Qing , Wang Taifu , Leng Lizhi , Zheng Wei , Huang Jinrong , Fang Fang , Yang Ling , Chen Fang , Lin Ge , Wang Wen‐Jing , Kristiansen Karsten 
Published: May 2019

AbstractSeveral animal and human studies have demonstrated that sex affects kinetics and metabolism during early embryo development. However, the mechanism governing these differences at the molecular level before the expression of the sex‐determining gene SRY is unknown. We performed a systematic profiling of gene expression comparing male and female embryos using available single‐cell RNA‐sequencing data of 1607 individual cells from 99 human preimplantation embryos, covering development stages from 4‐cell to late blastocyst. We observed consistent chromosome‐wide transcription of autosomes, whereas expression from sex chromosomes exhibits significant differences after embryonic genome activation (EGA). Activation of the Y chromosome is initiated by expression of two genes, RPS4Y1 and DDX3Y, whereas the X chromosome is widely activated, with both copies in females being activated after EGA. In contrast to the stable activation of the Y chromosome, expression of X‐linked genes in females declines at the late blastocyst stage, especially in trophectoderm cells, revealing a rapid process of dosage compensation. This dynamic behavior results in a dosage imbalance between male and female embryos, which influences genes involved in cell cycle, protein translation and metabolism. Our results reveal the dynamics of sex chromosomes expression and silencing during early embryogenesis. Studying sex differences during human embryogenesis, as well as understanding the process of X chromosome inactivation and their effects on the sex bias development of in vitro fertilized embryos, will expand the capabilities of assisted reproductive technology and possibly improve the treatment of infertility and enhance reproductive health.
Ultrasound‐guided treatment of peripheral entrapment mononeuropathies
Authors: Norbury John W. , Nazarian Levon N. 
Published: May 2019

ABSTRACTThe advent of high‐resolution neuromuscular ultrasound (US) has provided a useful tool for conservative treatment of peripheral entrapment mononeuropathies. US‐guided interventions require careful coordination of transducer and needle movement along with a detailed understanding of sonoanatomy. Preprocedural planning and positioning can be helpful in performing these interventions. Corticosteroid injections, aspiration of ganglia, hydrodissection, and minimally invasive procedures can be useful nonsurgical treatments for mononeuropathies refractory to conservative care. Technical aspects as well as the current understanding of the indications and efficacy of these procedures for common entrapment mononeuropathies are reviewed in this study. Muscle Nerve, 2019
The moderating effect of perceived organizational support in the relationship between emotional labour and job attitudes: A study among health professionals
Authors: Lartey Joshua King Safo , Amponsah‐Tawiah Kwesi , Osafo Joseph 
Published: May 2019

AbstractAimThe present study was set out to establish the link between emotional labour (surface and deep acting) and job attitudes (job satisfaction organizational commitment) by introducing perceived organizational support as a moderating variable.DesignThe study made use of a cross‐sectional design by sampling three hundred and forty‐two (342) nurses and midwives from six health facilities in Ghana.MethodsThe study employed a quantitative approach to examine the relationships between the study variables.ResultsThe study disclosed that whereas surface acting related negatively with job satisfaction but not with organizational commitment, deep acting did not relate significantly with both job satisfaction and organizational commitment. Perceived organizational support as a moderating variable showed a significant moderating effect between surface acting and job attitudes. However, Perceived organizational support moderated the relationship between deep acting and organizational commitment but not job satisfaction. The findings pose much contextual relevance to health professionals where emotional regulations are core responsibilities of health care.
Synthesis of boronic acid‐functionalized poly(glycerol‐oligoγ‐butyrolactone): Nano‐networks for efficient electrochemical sensing of biosystems
Authors: Hatamvand Roshanak , Shams Azim , Mohammadifar Ehsan , Yari Abdollah , Adeli Mohsen 
Published: May 2019

ABSTRACTDespite the outstanding properties of hyperbranched polyglycerols such as biocompatibility and multifunctionality, enough attention has not been paid to the synthesis of their functional copolymers. This problem has limited the structural diversity of hyperbranched polyglycerols and hampers further developments and their practical usage. In this work, butyrolactone segments were incorporated into the backbone of polyglycerols by one‐pot ring‐opening copolymerization of a mixture of glycidol and γ‐butyrolactone in the presence of tin(II) 2‐ethylhexanoate. Poly(glycerol‐oligoγ‐butyrolactone)s were then crosslinked by 2,5‐thiophenediylbisboronic acid to obtain polymeric nanonetworks with 140 nm average size. Afterwards, the gold electrode was modified by the polymeric nano‐networks, and it was used for the determination of glucose, glycated hemoglobin, and Escherichia coli in phosphate buffer solution (pH = 9.0) through cyclic voltammetry and impedance spectroscopic. Taking advantage of the straightforward synthesis, cheap precursors and multifunctionality of poly(glycerol‐oligoγ‐butyrolactone)s, they could be used for real‐time sensing of a wide range of biosystems. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1430–1439