bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pursuing foreign investment for nationalist goals: Venezuela's hybrid resource nationalism
Authors: Rosales Antulio 
Published: May 2018

AbstractScholarship in international political economy (IPE) has noted the rise of resource nationalism in since the early 2000s. Despite the increased presence of state regulation in the resource sector, resource nationalism has not been incompatible with foreign investment. This article contributes to better understand resource nationalist policies that emerged in recent years and offers new theoretical insights to explain state-IOC relations by integrating obsolescing bargaining theories and constructivist approaches. Drawing on the case of Venezuela, this article explains how the Chávez regime pursued a hybrid model of control and welcoming of investments in the oil sector. The article argues that both bargaining insights and ideational considerations are important in explaining this model. In the context of high oil prices and sunk investments, it is unsurprising that a leftist government would seek to renegotiate contracts to seek better deals from extractive companies. Yet, focusing exclusively on those incentives misses important ideational drivers for the government to keep investors in the country. For Chávez's government, effecting changes in the oil policy was possible after waging an intense battle with its NOC, PDVSA, over control. Association with foreign investment became crucial to build its socialist model and to control its own company.
The earliest Elcanidae (Insecta, Orthoptera) from the Upper Triassic of North America
Authors: Fang Yan , Muscente A.D. , Heads Sam W. , Wang Bo , Xiao Shuhai 
Published: May 2018

AbstractA new genus and species of the Elcanidae (Orthoptera, Elcanoidea), Cascadelcana virginiana n. gen. n. sp., is described based on a forewing specimen from the Upper Triassic (Norian) Cow Branch Formation in the Solite Quarry Lagerstätte near the North Carolina-Virginia boundary, USA. It is distinguished from other elcanid species by its RP+MA1 with six branches, M with two branches before stem MA1 fused with RP, and short CuA almost vertical against the posterior margin. This fossil represents the earliest definitive record of the family Elcanidae and the first orthopteran described from the Triassic of North America. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) analyses show that the veins and a pterostigma-like structure on the wing of C. virginiana n. gen. n. sp. are preserved as carbonaceous compressions. The presence of a pterostigma-like structure in elcanids indicates that they may have evolved a particular flight mechanism distinct from those of other orthopterans.UUID: http://zoobank.org/49526c99-5da4-48e3-ba6e-7018b8f9b1ae
r-Process Nucleosynthesis in the Early Universe Through Fast Mergers of Compact Binaries in Triple Systems
Authors: Bonetti Matteo , Perego Albino , Capelo Pedro R. , Dotti Massimo , Miller M. Coleman 
Published: May 2018

AbstractSurface abundance observations of halo stars hint at the occurrence of r-process nucleosynthesis at low metallicity ([Fe/H] < -3), possibly within the first 108 yr after the formation of the first stars. Possible loci of early-Universe r-process nucleosynthesis are the ejecta of either black hole–neutron star or neutron star–neutron star binary mergers. Here, we study the effect of the inclination–eccentricity oscillations raised by a tertiary (e.g. a star) on the coalescence time-scale of the inner compact object binaries. Our results are highly sensitive to the assumed initial distribution of the inner binary semi-major axes. Distributions with mostly wide compact object binaries are most affected by the third object, resulting in a strong increase (by more than a factor of 2) in the fraction of fast coalescences. If instead the distribution preferentially populates very close compact binaries, general relativistic precession prevents the third body from increasing the inner binary eccentricity to very high values. In this last case, the fraction of coalescing binaries is increased much less by tertiaries, but the fraction of binaries that would coalesce within 108 yr even without a third object is already high. Our results provide additional support to the compact-binary merger scenario for r-process nucleosynthesis.
Radiocarbon and Stable Carbon Isotopes of Labile and Inert Organic Carbon in the Critical Zone Observatory in Illinois, USA
Authors: Wang Hong , Stumpf Andrew J. , Kumar Praveen 
Published: May 2018

ABSTRACTWe applied the high temperature pyrolysis-combustion technique to partition the total soil organic carbon (SOC) into labile and inert carbon pools for accelerator mass spectrometry radiocarbon (AMS 14C) dating and stable carbon isotope (δ13C), SOC, and carbonate carbon (CC) content analyses to examine SOC variability at a Critical Zone Observatory site in Illinois, USA. The AMS 14C dates of labile and inert carbon in the top 1.55 m overlap except in the Bt horizon. Below 1.55 m the labile carbon is younger by 8000–14,800 years. The SOC content decreases from 3.61% to 0.12% and CC content increases from 0% to 19.16% at this depth. Results indicate that SOC production exceeds its loss in the weathering zone causing a continuous turnover of both SOC pools. A small amount of modern SOC infiltrates into deeper sediment below 1.55 m, making the labile carbon pool much younger. Their difference of AMS 14C contents, ΔF14C, reveals 3−5% more modern carbon in the labile SOC pools except in the Bt horizon, further quantifying that <3−5% modern carbon with potential pollutants is translocated into the unweathered sediments. The δ13C reveals the sources for SOC cycling dynamics in both carbon pools at this site.
FERTILISER APPLICATION PRACTICES AND NUTRIENT DEFICIENCIES IN SMALLHOLDER OIL PALM PLANTATIONS IN INDONESIA
Authors: WOITTIEZ LOTTE S. , TURHINA SRI , DECCY DESNAWATY , SLINGERLAND MAJA , VAN NOORDWIJK MEINE , GILLER KEN E. 
Published: May 2018

SUMMARYOil palm has become an important source of revenue for smallholders in Indonesia, but productivity of smallholder plantations is generally poor. Nutrient limitations have been suggested as an important agronomic constraint to yield. Our research aimed to quantify fertiliser use, soil and tissue nutrient status, and palm growth and yield in a sample of independent smallholder plantations. We selected 49 plantations in Indonesia in two provinces with contrasting soils. For all plantations, we obtained self-reported fertiliser use and yield data, collected soil and tissue samples, and analysed vegetative growth. More than 170 kg N ha−1year−1was applied in one site, and P was applied in excess of recommended quantities in both sites, but on average farmers applied less than 100 kg K ha−1year−1. Soils in the palm circle were poor in N, P and K in 29, 40 and 82% of the plantations, and deficiencies were measured in 57, 61 and 80% of the leaflet samples, respectively. We found statistically significant correlations between tissue nutrient concentrations and vegetative growth, but a large part of the variation in the data remained unaccounted for. Single leaf area was reduced in &gt;80% of the plantations. Average yields were estimated to be 50‒70% of the water-limited potential. Our results demonstrate that widespread nutrient imbalances and deficiencies, especially potassium and phosphorus, occur in smallholder oil palm plantations, due to inadequate and unbalanced fertiliser application practices. These deficiencies may be an important underlying cause of the overall poor productivity, which threatens the economic and environmental sustainability of the smallholder sector.
LAS SUBVENCIONES ADICIONALES EN LA COMPAÑÍA FERROVIARIA MZA
Authors: Narbón David Carlos Castellvi , Gil Rafael Barquín 
Published: May 2018

AbstractThe construction of the rail network in Spain was supported by public aid. A part of them were “subvenciones adicionales”, which came from the exemption of the payment of customs duties on the imports of railway equipment. The exact amount of these grants is only known after 1870 when they were rather small. In this paper, we quantified them for the period 1857-1886 in the company MZA, by then the largest in the country. Moreover, we estimate the costs of the construction of the railway lines of that company until 1869 and how much did each of the sources of funding, public and private contributed. The main conclusion is that in MZA the State’s grants were higher than the shareholders’ investment.
Sociodemographic and geographical inequalities in under- and overnutrition among children and mothers in Bangladesh: a spatial modelling approach to a nationally representative survey
Authors: Mia Mohammad Nahid , Rahman M Shafiqur , Roy Paritosh K 
Published: May 2018

AbstractObjectiveTo investigate the sociodemographic and geographical variation in under- and overnutrition prevalence among children and mothers.DesignData from the 2014 Bangladesh Demographic and Health Survey were analysed. Stunting and wasting for children and BMI<18·5 kg/m2for mothers were considered as undernutrition; overweight was considered as overnutrition for both children and mothers. We estimated the prevalence and performed simple logistic regression analyses to assess the associations between outcome variables and predictors. Bayesian spatial models were applied to estimate region-level prevalence to identify the regions (districts) prone to under- and overnutrition.Settings/SubjectsChildren aged<5 years and their mothers aged 15–49 years in Bangladesh.ResultsA significant difference (P<0·001) was observed in both under- and overnutrition prevalence between poor and rich. A notable regional variation was also observed in under- and overnutrition prevalence. Stunting prevalence ranged from 20·3 % in Jessore to 56·2 % in Sunamgonj, wasting from 10·6 % in Dhaka to 19·2 % in Bhola, and overweight from 0·8 % in Shariatpur to 2·6 % in Dhaka. Of the sixty-four districts, twelve had prevalence of stunting and thirty-two districts had prevalence of wasting higher than the WHO critical threshold levels. Similarly, fifty-three districts had prevalence of maternal underweight higher than the national level. In contrast, the prevalence of overweight was comparatively high in the industrially equipped metropolitan districts.ConclusionsObserved sociodemographic and geographical inequalities imply slow progress in the overall improvement of both under- and overnutrition. Therefore, effective intervention programmes and policies need to be designed urgently targeting the grass-roots level of such regions.
Measuring the results of a workshop on installing anaerobic digesters on smaller livestock farms
Authors: Welsh Rick , Webb Michaele E. , Grimberg Stefan , Rogers Shane 
Published: May 2018

AbstractIt is accepted generally that anaerobic digesters (AD) are efficacious technologies for reducing greenhouse gas emissions from livestock operations (Pronto and Gooch, 2009). In addition, AD technology has a number of other potential benefits including: energy production for use on the farm and for sale, separation of manure solids for ease of use or export off-farm, pathogen reduction leading to healthier labor and herd outcomes and odor control. It is also clear that in the USA, research and extension efforts, including public financing of AD technology installations, have disproportionally been focused on larger farms- e.g., dairy farms with at least 500 milking cows. The latter has begun to change as more resources are being invested in AD technology for smaller livestock farms. We present the results of a pre and post survey implemented at four workshops on small-scale AD technology for livestock farmers in northeastern New York State. Results indicate that information presented shifted farmers’ attitudes such that they viewed AD technology as not overly complex; and, they became less interested in selling generated surplus power off-farm.
Initial Expansion of C4 Vegetation in Australia During the Late Pliocene
Authors: Andrae J. W. , McInerney F. A. , Polissar P. J. , Sniderman J. M. K. , Howard S. , Hall P. A. , Phelps S. R. 
Published: May 2018

AbstractSince the late Miocene, plants using the C4 photosynthetic pathway have increased to become major components of many tropical and subtropical ecosystems. However, the drivers for this expansion remain under debate, in part because of the varied histories of C4 vegetation on different continents. Australia hosts the highest dominance of C4 vegetation of all continents, but little is known about the history of C4 vegetation there. Carbon isotope ratios of plant waxes from scientific ocean drilling sediments off north‐western Australia reveal the onset of Australian C4 expansion at ~3.5 Ma, later than in many other regions. Pollen analysis from the same sediments reveals increasingly open C3‐dominated biomes preceding the shift to open C4‐dominated biomes by several million years. We hypothesize that the development of a summer monsoon climate beginning in the late Pliocene promoted a highly seasonal precipitation regime favorable to the expansion of C4 vegetation.
Grainyhead-like 2 (GRHL2) knockout abolishes oral cancer development through reciprocal regulation of the MAP kinase and TGF-β signaling pathways
Authors: Chen Wei , Kang Kyung L. , Alshaikh Abdullah , Varma Saaket , Lin Yi-Ling , Shin Ki-Hyuk , Kim Reuben , Wang Cun-Yu , Park No-Hee , Walentin Katharina , Schmidt-Ott Kai M. , Kang Mo K. 
Published: May 2018

AbstractGrainyhead-Like 2 (GRHL2) is an epithelial-specific transcription factor that regulates epithelial morphogenesis and differentiation. Prior studies suggested inverse regulation between GRHL2 and TGF-β in epithelial plasticity and potential carcinogenesis. Here, we report the role of GRHL2 in oral carcinogenesis in vivo using a novelGrhl2knockout (KO) mouse model and the underlying mechanism involving its functional interaction with TGF-β signaling. We developed epithelial-specificGrhl2conditional KO mice by crossingGrhl2floxed mice with those expressing CreER driven by the K14 promoter. After induction ofGrhl2KO, we confirmed the loss of GRHL2 and its target proteins, whileGrhl2KO strongly induced TGF-β signaling molecules. When exposed to 4-nitroquinoline 1-oxide (4-NQO), a strong chemical carcinogen,Grhl2wild-type (WT) mice developed rampant oral tongue tumors, whileGrhl2KO mice completely abolished tumor development. In cultured oral squamous cell carcinoma (OSCC) cell lines, TGF-β signaling was notably induced by GRHL2 knockdown while being suppressed by GRHL2 overexpression. GRHL2 knockdown or KO in vitro and in vivo, respectively, led to loss of active p-Erk1/2 and p-JNK MAP kinase levels; moreover, ectopic overexpression of GRHL2 strongly induced the MAP kinase activation. Furthermore, the suppressive effect of GRHL2 on TGF-β signaling was diminished in cells exposed to Erk and JNK inhibitors. These data indicate that GRHL2 activates the Erk and JNK MAP kinases, which in turn suppresses the TGF -β signaling. This novel signaling represents an alternative pathway by which GRHL2 regulates carcinogenesis, and is distinct from the direct transcriptional regulation by GRHL2 binding at its target gene promoters, e.g., E-cadherin, hTERT, p63, and miR-200 family genes. Taken together, the current study provides the first genetic evidence to support the role of GRHL2 in carcinogenesis and the underlying novel mechanism that involves the functional interaction between GRHL2 and TGF-β signaling through the MAPK pathways.
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells
Authors: Uenishi Gene I. , Jung Ho Sun , Kumar Akhilesh , Park Mi Ae , Hadland Brandon K. , McLeod Ethan , Raymond Matthew , Moskvin Oleg , Zimmerman Catherine E. , Theisen Derek J. , Swanson Scott , J. Tamplin Owen , Zon Leonard I. , Thomson James A. , Bernstein Irwin D. , Slukvin Igor I. 
Published: May 2018

AbstractNOTCH signaling is required for the arterial specification and formation of hematopoietic stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad-mesonephros region and extraembryonic vasculature from a distinct lineage of vascular endothelial cells with hemogenic potential. However, the role of NOTCH signaling in hemogenic endothelium (HE) specification from human pluripotent stem cell (hPSC) has not been studied. Here, using a chemically defined hPSC differentiation system combined with the use of DLL1-Fc and DAPT to manipulate NOTCH, we discover that NOTCH activation in hPSC-derived immature HE progenitors leads to formation of CD144+CD43−CD73−DLL4+Runx1 + 23-GFP+ arterial-type HE, which requires NOTCH signaling to undergo endothelial-to-hematopoietic transition and produce definitive lympho-myeloid and erythroid cells. These findings demonstrate that NOTCH-mediated arterialization of HE is an essential prerequisite for establishing definitive lympho-myeloid program and suggest that exploring molecular pathways that lead to arterial specification may aid in vitro approaches to enhance definitive hematopoiesis from hPSCs.
In situ coherent diffractive imaging
Authors: Lo Yuan Hung , Zhao Lingrong , Gallagher-Jones Marcus , Rana Arjun , J. Lodico Jared , Xiao Weikun , Regan B. C. , Miao Jianwei 
Published: May 2018

AbstractCoherent diffractive imaging (CDI) has been widely applied in the physical and biological sciences using synchrotron radiation, X-ray free-electron laser, high harmonic generation, electrons, and optical lasers. One of CDI’s important applications is to probe dynamic phenomena with high spatiotemporal resolution. Here, we report the development of a general in situ CDI method for real-time imaging of dynamic processes in solution. By introducing a time-invariant overlapping region as real-space constraint, we simultaneously reconstructed a time series of complex exit wave of dynamic processes with robust and fast convergence. We validated this method using optical laser experiments and numerical simulations with coherent X-rays. Our numerical simulations further indicated that in situ CDI can potentially reduce radiation dose by more than an order of magnitude relative to conventional CDI. With further development, we envision in situ CDI could be applied to probe a range of dynamic phenomena in the future.
Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma
Authors: MacGregor T. P. , Carter R. , Gillies R. S. , Findlay J. M. , Kartsonaki C. , Castro-Giner F. , Sahgal N. , Wang L. M. , Chetty R. , Maynard N. D. , Cazier J. B. , Buffa F. , McHugh P. J. , Tomlinson I. , Middleton M. R. , Sharma R. A. 
Published: May 2018

AbstractOxaliplatin-based chemotherapy is used to treat patients with esophageal adenocarcinoma (EAC), but no biomarkers are currently available for patient selection. We performed a prospective, clinical trial to identify potential biomarkers associated with clinical outcomes. Tumor tissue was obtained from 38 patients with resectable EAC before and after 2 cycles of oxaliplatin-fluorouracil chemotherapy. Pre-treatment mRNA expression of 280 DNA repair (DNAR) genes was tested for association with histopathological regression at surgery, disease-free survival (DFS) and overall survival (OS). High expression of 13 DNA damage repair genes was associated with DFS less than one year (P < 0.05); expression of 11 DNAR genes were associated with worse OS (P < 0.05). From clinical associations with outcomes, two genes,ERCC1andEME1, were identified as candidate biomarkers. In cell linesin vitro, we showed the mechanism of action related to repair of oxaliplatin-induced DNA damage by depletion and knockout of protein binding partners of the candidate biomarkers, XPF and MUS81 respectively. In clinical samples from the clinical trial, pre-treatment XPF protein levels were associated with pathological response, and MUS81 protein was associated with 1-year DFS. XPF and MUS81 merit further validation in prospective clinical trials as biomarkers that may predict clinical response of EAC to oxaliplatin-based chemotherapy.
A Small-Angle Neutron Scattering Environment for In-Situ Observation of Chemical Processes
Authors: Hayward Dominic W. , Chiappisi Leonardo , Prévost Sylvain , Schweins Ralf , Gradzielski Michael 
Published: May 2018

AbstractA new sample environment for the observation of ongoing chemical reactions is introduced for small-angle neutron scattering (SANS) experiments which enables structural changes to be followed continuously across a wide Q-range in response to changes in the chemical environment. The approach is demonstrated and validated by performing single and multiple potentiometric titrations on an aqueous anionic surfactant solution (oligo-oxyethylene alkylether carboxylic acid in D2O) with addition times varying from 1 s to 2 h. It is shown that the continuous flow set-up offers considerable advantages over classical ‘static’ measurements with regards to sample throughput, compositional precision and the ability to observe fast structural transitions. Finally, the capabilities and ongoing optimisation of the sample environment are discussed with reference to potential applications in the fields of biology, colloidal systems and complex soft matter.
Time-to-death approach to reveal chronic and cumulative toxicity of a fungicide for honeybees not revealed with the standard ten-day test
Authors: Simon-Delso Noa , San Martin Gilles , Bruneau Etienne , Hautier Louis 
Published: May 2018

AbstractSynthetic fungicides are pesticides widely used in agriculture to control phytopathogenic fungi. The systemicity, persistency and intense application of some of these fungicides, such as boscalid, leads to long periods of exposure for honeybees via contaminated water, pollen and nectar. We exposed adult honeybees in the lab to food contaminated with boscalid for 33 days instead of the standard 10-day test. Most of the toxic effects were observed after 10 days. The median time to death (LT50) ranged from 24.9 days (lowest concentration) to 7.1 days (highest concentration) and was significantly shorter in all cases than with the control (32.0 days). The concentration and dietary doses of boscalid inducing 50% mortality (LC50 and LDD50, respectively) decreased strongly with the time of exposure: LC50 = 14,729 and 1,174 mg/l and LDD50 = 0.318 and 0.0301 mg bee−1 day−1 at days 8 and 25, respectively. We found evidence of reinforced toxicity when exposure is prolonged, but with an unusual pattern: no cumulative toxicity is observed until 17–18 days, when a point of inflexion appears that suggests a reduced capacity of bees to deal with the toxicant. Our results show the importance of time-to-death experiments rather than fixed-duration studies for evaluating chronic toxicity.
A Cluster-then-label Semi-supervised Learning Approach for Pathology Image Classification
Authors: Peikari Mohammad , Salama Sherine , Nofech-Mozes Sharon , Martel Anne L. 
Published: May 2018

AbstractCompletely labeled pathology datasets are often challenging and time-consuming to obtain. Semi-supervised learning (SSL) methods are able to learn from fewer labeled data points with the help of a large number of unlabeled data points. In this paper, we investigated the possibility of using clustering analysis to identify the underlying structure of the data space for SSL. A cluster-then-label method was proposed to identify high-density regions in the data space which were then used to help a supervised SVM in finding the decision boundary. We have compared our method with other supervised and semi-supervised state-of-the-art techniques using two different classification tasks applied to breast pathology datasets. We found that compared with other state-of-the-art supervised and semi-supervised methods, our SSL method is able to improve classification performance when a limited number of labeled data instances are made available. We also showed that it is important to examine the underlying distribution of the data space before applying SSL techniques to ensure semi-supervised learning assumptions are not violated by the data.