bluuebunny/crossref_metadata_2025_split huggingface dataset:
Von Generation zu Generation: Mechanismen der Risikoübertragung elterlicher psychischer Erkrankungen im frühen Kindesalter
Authors: Zietlow Anna-Lena , Krumpholtz Lea 
Published: November 2024

ZusammenfassungKinder, die mit einem psychisch kranken Elternteil aufwachsen, sind vielfältigen und weitreichenden Entwicklungsrisiken ausgesetzt. Die intergenerationale Übertragung elterlicher psychischer Störungen wird durch eine Vielzahl von Risiko- und Schutzfaktoren sowie vermittelnden Mechanismen beeinflusst, die sowohl aufseiten der Eltern und Kinder als auch im sozialen Umfeld liegen. Der Einfluss der elterlichen Psychopathologie ist in den ersten Lebensjahren besonders stark, beeinflusst aber auch die Entwicklung im Kindes- und Jugendalter und kann sich lebenslang negativ auf die psychische Gesundheit auswirken. Aufgrund der vielfältigen und langfristigen Auswirkungen auf die kindliche Entwicklung ist neben der Identifikation von Transmissionsfaktoren auch die Ableitung möglichst frühzeitiger Präventions- und Interventionsstrategien von hoher Relevanz, um die weitreichenden negativen Folgen für die Entwicklung der Heranwachsenden reduzieren zu können. Mögliche Ansatzpunkte hierfür bieten zum einen identifizierte Risiko- und Schutzfaktoren sowie vermittelnde Mechanismen zwischen elterlicher Psychopathologie und kindlicher Entwicklung. Diese Faktoren und ihre Auswirkungen auf die frühkindliche Entwicklung werden im vorliegenden narrativen Review auf der Basis des aktuellen Forschungsstandes dargestellt. Darüber hinaus werden Forschungslücken identifiziert und Implikationen für die Ableitung früher Interventionen diskutiert.
Infektion durch Ostseewasser erfordert großflächige Mesh-Haut-Transplantation am Universitätsklinikum Ulm
Authors: Kreß F. , Schenk P. , Gebhard F. , Schütze K. 
Published: November 2024

Zusammenfassung

Vibrio vulnificus (V. vulnificus) ist ein gramnegatives Bakterium, das schwere Infektionen verursachen kann, wenn es über offene Wunden oder den Verzehr von Schalentieren in den menschlichen Körper gelangt. Vermehrtes Auftreten der Bakterien ist bei Wassertemperaturen > 20 °C bekannt. Außerdem ist ein geringer Salzgehalt von 5–25 ‰ für das Vermehren von Vibrionen förderlich. In der Übersichtsarbeit von Fleischmann et al. wird der direkte Zusammenhang von niedrigem Salzgehalt und hoher Wassertemperatur mit dem vermehrten Auftreten von V. vulnificus an deutschen Ostseeküsten aufgezeigt [7]. Es kann zu einer fulminanten nekrotisierenden Fasziitis kommen, die einen septischen Schock, eine Amputation und den Tod zur Folge haben kann.
Dieser Fallbericht zeigt die erfolgreiche chirurgische Behandlung einer fulminanten Unterschenkelinfektion mit septischem Schock nach Kontakt mit Ostseewasser in Deutschland. Nach einem schnellen und großflächigen Débridement folgte die erfolgreiche Transplantation von Hautgewebe mittels Mesh-Graft.
A New Guiding Suturing Technique for Reshaping of the Antihelix in Patients with Prominent Ears
Authors: Altramsy Ayman , Dahy Asmaa Ali , Gad Amany Attalah , Abu-Elsoud Ahmed , Khattab Rania Fouad , Nafeh Ahmed Mamdouh , Azzam Rasheda , Elameen Ali Mohamed 
Published: November 2024

Abstract
Background
Prominent ears are the most common congenital anomaly of the head and neck. A complete understanding of the definition of prominent ears is necessary. The present retrospective study described guiding sutures to hold the antihelix in a temporary corrected position before placing the permanent Mustardé sutures.

Methods
This study was performed between January 2021 and February 2023. All patients with prominent ear deformities subjected to guiding sutures and Mustardé-based otoplasty were included. The surgical-related outcomes and surgeons’ satisfaction were evaluated. The patients’ satisfaction and health-related quality of life were reported.

Results
The current study included 60 patients with prominent ear deformities. There were 34 (56.66%) males and 26 (43.33%) females with a mean age of 12.2±7.8 years. The mean total operative time was 49±22 minutes. Five (8.33%) patients had suture extrusion, and no case of asymmetry, recurrence, or skin necrosis was documented. There were 55 (91.66%) patients satisfied with the final appearance of their ears, and five (8.33%) patients were not satisfied. The mean general health subscale was 57.1±6.9, and the mean physical health subscale was 8.7±1.5.

Conclusions
The guiding sutures allowed easy accessibility for reshaping the antihelix in patients with prominent ears. These sutures allowed a relatively shorter operative time, and stable reshaping of the antihelix allowed for a shorter recovery time. This was associated with a low complication rate with no asymmetry, recurrence, or revision surgery. Patients operated on under local anesthesia achieved shorter operative time and better pain control.

Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Application of artificial intelligence in laryngeal lesions: a systematic review and meta-analysis
Authors: Marrero-Gonzalez Alejandro R. , Diemer Tanner J. , Nguyen Shaun A. , Camilon Terence J. M. , Meenan Kirsten , O’Rourke Ashli 
Published: November 2024

Abstract
Objective
The objective of this systematic review and meta-analysis was to evaluate the diagnostic accuracy of AI-assisted technologies, including endoscopy, voice analysis, and histopathology, for detecting and classifying laryngeal lesions.

Methods
A systematic search was conducted in PubMed, Embase, etc. for studies utilizing voice analysis, histopathology for laryngeal lesions, or AI-assisted endoscopy. The results of diagnostic accuracy, sensitivity and specificity were synthesized by a meta-analysis.

Results
12 studies employing AI-assisted endoscopy, 2 studies for voice analysis, and 4 studies for histopathology were included in the meta-analysis. The combined sensitivity of AI-assisted endoscopy was 91% (95% CI 87–94%) for the classification of benign from malignant lesions and 91% (95% CI 90–93%) for lesion detection. The highest accuracy pooled in detecting lesions versus healthy tissue was the AI-aided endoscopy was 94% (95% CI 92–97%).

Conclusions
For laryngeal lesions, AI-assisted endoscopy shows excellent diagnosis accuracy. But more sizable prospective trials are needed to confirm the practical clinical value.
A comparison of cycloplegic effect of cyclopentolate 0.5% versus 1.0% eye drops with five different refraction measurement modalities in young adults
Authors: Kaiser Klemens Paul , Lwowski Christoph , Nazir Faisal , Kohnen Thomas , Wenner Yaroslava 
Published: November 2024

Abstract
Purpose
To compare the refraction before and after cycloplegia with 0.5% and 1.0% cyclopentolate eye drops using five different measurement modalities.

Methods
This prospective, clinical comparative study enrolled 96 eyes of 48 healthy patients with a mean age of 26.6 ± 4.21 years (range: 19–34). Subjective refraction, retinoscopy, and objective refraction were measured using three autorefractometers: Topcon KR-800 (TC), Retinomax K-plus 3 (RM + 3), and Retinomax K-plus Screeen (RM + S) under noncycloplegic and cycloplegic conditions. Cycloplegia was performed in the right eye using 0.5% and in the left eye with 1.0% cyclopentolate eye drops. Differences in refraction in noncycloplegia and cycloplegia, between cycloplegia with 0.5% and 1.0% cyclopentolate, and between the devices were investigated.

Results
Cycloplegic mean spherical equivalent was -1.77 ± 2.34 diopters (D) (-9.75 to + 1.625). All approaches showed a statistically significant hyperopic shift (p < 0.001, each) after induction of cycloplegia using both regimes. Lowest median (interquartile range) hyperopic shift was shown by TC (0.25 D (0.38)) and retinoscopy (0.25D (0.75)), and the highest by RM + 3 (0.75 (1.31)). No statistically significant differences between cycloplegia using 0.5% and 1.0% regimens were shown in all modalities (p > 0.05, each). In noncycloplegia, there were greater differences compared to cycloplegia. No influence of iris color on the refraction was found.

Conclusion
After induction of cycloplegia all devices showed a hyperopic shift and good comparability to retinoscopy. In all measurement modalities, no significant refraction differences between 0.5% and 1.0% cyclopentolate eye drops were seen. Therefore, 0.5% cyclopentolate was proven to have a sufficient effect with presumably better tolerability.

Key messages
What is known

Cycloplegic refraction is a key test in the evaluation of any patient with active accommodation.

The most frequently used clinical tests to determine the exact refraction are retinoscopy, subjective refraction, and objective refraction using autorefractometry.

What is new

No significant differences in the refraction between cycloplegia using 0.5% and 1.0% cyclopentolate eye drops were found.

In noncycloplegia, hand-held autorefractometers tend to measure higher myopia.

The evaluation of cycloplegic refraction showed good comparability between retinoscopy and subjective refraction as well as three different autorefractometers.
Predictive risk scores for visual prognosis after photodynamic therapy for central serous chorioretinopathy
Authors: Funatsu Ryoh , Terasaki Hiroto , Mihara Naohisa , Shiihara Hideki , Sonoda Shozo , Sakamoto Taiji 
Published: November 2024

Abstract
Purpose
To comprehensively evaluate baseline characteristics of patients with central serous chorioretinopathy (CSC) and develop predictive risk scores to identify visual prognosis.

Methods
This single-institute, retrospective cohort study included 144 eyes of 144 patients with CSC who underwent photodynamic therapy and achieved serous retinal detachment resolution. We developed and assessed the performance of several risk scores for best-corrected visual acuity (BCVA) outcomes six months post-treatment: i) BCVA improvement (≤-1.0 logMAR), and ii) BCVA deterioration (≥+ 1.0 logMAR).

Results
The BCVA improvement models used photoreceptor outer segment thickness, loss of photoreceptor outer segment, and neurosensory retinal thickness (NSRT), while the BCVA deterioration models included outer nuclear layer thickness and NSRT. The BCVA improvement models demonstrated a corrected area under the curve (AUC) of 0.786 (95% confidence interval [CI]: 0.699–0.864), with 80.4% sensitivity, and 71.2% specificity. The BCVA deterioration models achieved a corrected AUC of 0.864 (95% CI: 0.742–0.958), with 85.7% sensitivity, and 83.5% specificity.

Conclusion
The predictive models for CSC exhibited favorable performance in predicting individual visual prognoses. A thinner outer nuclear layer may be associated with BCVA deterioration, whereas preservation of the photoreceptor outer segment may be correlated with BCVA improvement.

Key Messages

What is known

Pre-treatment best-corrected visual acuity, thickness of each sensory retinal layer, time from onset to treatment, and macular atrophy were each found to be associated with visual prognosis for patients with central serous chorioretinopathy (CSC).

What is new

The current study comprehensively assessed potential prognostic factors and precisely identified individual likelihood of visual prognosis.

The study found that different regions of the sensory retina were associated with either worsening or improving visual acuity.

Accurately predicting visual outcomes after photodynamic therapy for CSC would help healthcare providers create personalized treatment plans and enable patients to make informed decisions about their treatment based on their expected visual results.
Skeletal muscle hypertrophy and enhanced mitochondrial bioenergetics following electrical stimulation exercises in spinal cord injury: a randomized clinical trial
Authors: Gorgey Ashraf S. , Khalil Refka E. , Carter William , Rivers Jeannie , Chen Qun , Lesnefsky Edward J. 
Published: November 2024

AbstractWe examined the combined effects of neuromuscular electrical stimulation-resistance training (NMES-RT) and functional electrical stimulation-lower extremity cycling (FES-LEC) compared to passive movement training (PMT) and FES-LEC on mitochondrial electron transport chain (ETC) complexes and citrate synthase (CS) in adults with SCI. Thirty-two participants with chronic SCI were randomized to 24 weeks of NMES-RT + FES [n = 16 (14 males and 2 females) with an age range of 20–54 years old] or PMT + FES [n = 16 (12 males and 4 females) with an age range of 21–61 years old]. The NMES-RT + FES group underwent 12 weeks of surface NMES-RT using ankle weights followed by an additional 12 weeks of FES-LEC. The PMT + FES performed 12 weeks of passive leg extension movements followed by an additional 12 weeks of FES-LEC. Using repeated measures design, muscle biopsies of the vastus lateralis were performed at baseline (BL), post-intervention 1 (P1) and post-intervention 2 (P2). Spectrophotometer was used to measure ETC complexes (I-III) and CS using aliquots of the homogenized muscle tissue. Magnetic resonance imaging was used to measure skeletal muscle CSAs. A time effect was noted on CS (P = 0.001) with an interaction between both groups (P = 0.01). 46% of the participants per group had zero activities of CI without any changes following both interventions. A time effect was noted in CII (P = 0.023) following both interventions. Finally, NMES-RT + FES increased CIII at P1 compared to BL (P = 0.023) without additional changes in P2 or following PMT + FES intervention. Skeletal muscle hypertrophy may potentially enhance mitochondrial bioenergetics after SCI. NMES-RT is likely to enhance the activities of complex III in sedentary persons with SCI. Clinical trials # NCT02660073.
Softwaregestütze Bemessung von Betonbewehrung aus Basaltfasern
Authors: Steckbauer Martin Alfred , Evangelatos Alexandros , Galler Robert 
Published: November 2024

ZusammenfassungHohe Treibhausgasemissionen und Sanierungskosten der Stahlbewehrungen in Betonkonstruktionen stellen ein Problem dar, nichtmetallische Bewehrungen aus Basalt wären eine mögliche Alternative. Im folgenden Beitrag wird diese anhand der im kontinuierlichen Tunnelbau verwendeten Tübbinge untersucht. Dafür wurden vorerst stahlbewehrte Dreipunktbiegeversuche im Labormaßstab aus der Literatur numerisch mit dem Programm Sofistik zur Parameterabstimmung an einfachen Geometrien validiert. Anhand dieser Erkenntnisse wurden anschließend zwei unterschiedliche Stahlbetontübbinge des Koralmtunnels modelliert und berechnet. Die unterschiedlichen Modellkörper mit aus Versuchen validierten Parametern konnten nun in der Sofistik-Simulation mit Basaltbewehrung neu bemessen werden. Die numerischen Analysen ermöglichen erste Darstellungen des Einsparungspotenzials von Treibhausgasen an basaltbewehrten Betonbauteilen wie Tübbingen.
Gestärkt aus den Krisen: Bewältigungs- und Anpassungsmaßnahmen von Gastronomiebetrieben in Niedersachsen
Authors: Völlers Philip , Franz Martin , Verfürth Philip , Neise Thomas 
Published: November 2024

ZusammenfassungGastronomiebetriebe leisten einen wichtigen Beitrag zur sozioökonomischen Entwicklung von Städten und Dörfern. Trotz ihrer soziokulturellen und wirtschaftlichen Funktionen wurde die Gastronomie in der Stadt- und Gemeindeplanung, der Kommunalpolitik und der Wirtschaftsförderung lange Zeit nicht ausreichend berücksichtigt. Seit 2020 sind Gastronomiebetriebe in besonderem Maße von den Auswirkungen multipler Krisen betroffen. Dieser Artikel hat zum Ziel, die Auswirkungen dieser Krisensituationen auf die Gastronomie zu erfassen und die betrieblichen Maßnahmen zur Bewältigung dieser Krisen zu identifizieren. Die Untersuchung basiert auf einer Kombination aus quantitativer Umfrage unter Gastronomiebetrieben und qualitativen Interviews mit Gastronom*innen sowie Vertreter*innen relevanter Organisationen. Es zeigt sich, dass die sich überlappenden Krisen erhebliche betriebliche Auswirkungen haben. Etwa 40 % der Betriebe sehen ihre Existenz bedroht. Allerdings geben rund 36 % der Betriebe an, dass sie gestärkt aus den Krisen hervorgehen. Dies ist auf die Bewältigungs- und Anpassungsmaßnahmen und die sich verändernde Wettbewerbssituation zurückzuführen. Abschließend werden aus den Untersuchungsergebnissen Handlungsempfehlungen für Gastronom*innen, unterstützende Organisationen und die Politik abgeleitet.
Interpretation of Pressuremeter Test in Fractured and Weathered Phyllite for Back-Analysis of Pipe Jacking Forces
Authors: Phangkawira F. , Ong D. E. L. , Choo C. S. 
Published: November 2024

Abstract
Characterisation of highly fractured and weathered rock masses within the young Tuang Formation in Sarawak, Malaysia is challenging, mainly due to the difficulties in extracting intact samples for conventional rock testing. Pressuremeter test was used as a viable alternative since it is performed in-situ, hence eliminating the need for sample extraction. A methodology was developed to interpret pressuremeter test results in highly fractured and weathered phyllite using an analytical approach, from which useful strength and stiffness parameters can be obtained. The interpretation method was based on the fundamental theory of cylindrical cavity expansion, which was originally established for soils. The results of the interpretation were in terms of commonly known Mohr–Coulomb strength parameters, which were subsequently used for assessment of frictional pipe jacking forces through back-analysis method. The results of the back-analysis showed the reliability of the developed methodology in analysing pressuremeter test results within highly fractured and weathered phyllite.
Effectiveness of optic nerve sheath fenestration in preserving vision in idiopathic intracranial hypertension: an updated meta-analysis and systematic review
Authors: Prokop Kacper , Opęchowska Aleksandra , Sieśkiewicz Andrzej , Lisowski Łukasz , Mariak Zenon , Łysoń Tomasz 
Published: November 2024

Abstract

Background
This study aims to evaluate the effectiveness of Optic Nerve Sheath Fenestration (ONSF) in improving visual outcomes in patients with Idiopathic Intracranial Hypertension (IIH).

Methods
A meta-analysis was conducted using data from 19 studies, totaling 1159 observations. The main assessed outcomes after ONSF surgery were: the improvement in visual acuity, the improvement in visual fields and reduction in papilledema. We performed separate analyses to distinguish between outcomes using different surgical approaches. Comprehensive literature searches were conducted in the Ovid MEDLINE(R) and SCOPUS databases, following PRISMA guidelines. Statistical analyses employed a Generalized Linear Mixed Model (GLMM) to integrate proportion data, with heterogeneity assessed via I-squared and H statistics. Publication bias was evaluated using funnel plots, Egger's test, and Peters' test.

Results
The analysis revealed that ONSF significantly improved visual acuity in 41.09% of patients, and visual fields in 76.34% of cases. The transconjunctival approach demonstrated higher success rates for visual field improvement. A high improvement rate of 97% was observed in reducing optic disc swelling. Significant heterogeneity was noted, particularly in visual acuity (I2 = 92.1%) and visual field improvements (I2 = 73.8%), reflecting variability in surgical techniques and patient demographics. Publication bias assessments indicated no significant bias for visual acuity and visual field outcomes, although potential bias was detected for papilledema reduction.

Conclusions
This meta-analysis confirms that ONSF is effective in improving visual outcomes for IIH patients, especially when using the transconjunctival approach. Early surgical intervention is crucial for optimal results, principally in preventing advanced ischemic damage. Despite high success rates, observed heterogeneity highlights the need for standardized surgical techniques and further investigation into patient-specific factors influencing outcomes. Addressing potential publication bias and conducting more rigorous studies will enhance the reliability of future meta-analyses. Upcoming research in ONSF efficacy is needed to refine surgical practices and optimize patient care.
Idiopathic normal pressure hydrocephalus: survey on current diagnostic and therapeutic procedures in clinical practice in Germany
Authors: Al-Tarawni Fadi , Abdulbaki Arif , Polemikos Manolis , Kaminsky Jan , Trost Hans A. , Woitzik Johannes , Krauss Joachim K. 
Published: November 2024

Abstract

Objective
Cerebrospinal fluid (CSF) shunting has become the standard treatment for idiopathic normal pressure hydrocephalus (NPH). Nevertheless, there is still disagreement on diagnostic criteria for selecting patients for surgery and optimal shunt management. The primary aim of the present study was to provide an update on the status of best practice, the use of different diagnostic algorithms and therapeutic management of idiopathic NPH in an European country.

Methods
A standardized questionnaire with sections on the assessment of clinical symptoms and signs of NPH, diagnostic work-up, therapeutic decision making, and operative techniques was sent to 135 neurosurgical clinics in Germany that regularly perform shunt surgeries.

Results
Overall, responses were received from 114/135 (84.4%) clinics. Most responders considered gait disturbance to be the hallmark clinical sign of idiopathic NPH (96%). A lumbar tap test was utilized always/ mostly by 97 centers (86%). In 43% of the centers, 30–40 ml CSF were removed with the spinal tap test. Spinal dynamic CSF studies were used by 12 centers only occasionally, and only by 1 center always for diagnostic purposes. Ventriculo-peritoneal shunting was the most frequent type of CSF diversion (> 90%). Pressure-controlled valves were used by the majority of units (95%) Overall 102 centers (93%) always/mostly used adjustable valves, and antisiphon devices were used always/ mostly in 50% of units.

Conclusion
The present survey demonstrates that there has been a remarkable change of practice and opinions on the diagnosis and treatment of idiopathic NPH over the past two decades in Germany. Remarkably, variabilities in practice among different centers are less common than previously and recommendations according to scientific publications and guidelines have been implemented more readily.