bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of Nonlinear Optical Scattering by Gold Nanoparticles through Aggregation‐Induced Plasmon Coupling in the Near‐Infrared
Authors: de Coene Yovan , Deschaume Olivier , Zhang Yuqing , Billen Arne , He Jing , Seré Stephanie , Knoppe Stefan , Van Cleuvenbergen Stijn , Verbiest Thierry , Clays Koen , Ye Jian , Bartic Carmen 
Published: April 2019

AbstractGold nanoparticles (AuNPs) are regarded as promising building blocks in functional nanomaterials for sensing, drug delivery and catalysis. One remarkable property of these particles is the localized surface plasmon resonance (LSPR), which gives rise to augmented optical properties through local field enhancement. LSPR also influences the nonlinear optical properties of metal NPs (MNPs) making them potentially interesting candidates for fast, high resolution nonlinear optical imaging. In this work we characterize and discuss the wavelength dependence of the hyper‐Rayleigh scattering (HRS) behavior of spherical gold nanoparticles (GNP) and gold nanorods (GNR) in solution, from 850 nm up to 1300 nm, covering the near‐infrared (NIR) window relevant for deep tissue imaging. The high‐resolution spectral data allows discriminating between HRS and two photon photoluminescence contributions. Upon particle aggregation, we measured very large enhancements (ca. 104) of the HRS intensity in the NIR, which is explained by considering aggregation‐induced plasmon coupling effects and local field enhancement. These results indicate that purposely designed coupled nanostructures could prove advantageous for nonlinear optical imaging and biosensing applications.
New Boron(III) Blue Emitters for All‐Solution Processed OLEDs: Molecular Design Assisted by Theoretical Modeling
Authors: Salla Cristian A. M. , Teixeira dos Santos Jéssica , Farias Giliandro , Bortoluzi Adailton J. , Curcio Sergio F. , Cazati Thiago , Izsák Róbert , Neese Frank , de Souza Bernardo , Bechtold Ivan H. 
Published: April 2019

AbstractInvited for the cover of this issue is Ivan Bechtold from Universidade Federal de Santa Catarina, Florianópolis, Brazil. The cover image shows the ideal cycle of prediction‐testing‐update that is demonstrated in this work, focusing on the most efficient blue‐emitting boron complex synthesized and the OLED made from it.
Collagen‐alginate‐nano‐silica microspheres improved the osteogenic potential of human osteoblast‐like MG‐63 cells
Authors: Khatami Neda , Khoshfetrat Ali Baradar , Khaksar Majid , Zamani Arezoo Rezaie Nezhad , Rahbarghazi Reza 
Published: April 2019

AbstractModular bone tissue engineering is touted as an alternative approach to replace the damaged bone tissue. Hydrogel microcapsules could promote therapeutic properties by providing 3D condition and an increased cell‐to‐cell interaction. We investigated the osteogenic properties of alginate‐nano‐silica hydrogels enriched with collagen and gelatin on human osteoblast‐like MG‐63 cells. For encapsulation, cells were divided into three groups; control (alginate+ nano‐silica), collagen (alginate + collagen + nano‐silica), and gelatin (alginate + gelatin + nano‐silica) and expanded for 28 days. Cell survival was determined by trypan blue staining and 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) assay. To confirm the osteogenic potential, we measured the alkaline phosphatase activity. Alizarin red S staining was used to reveal the existence of hydroxyapatite and transcription BMP‐2, osteocalcin and osteonectin evaluated by the real‐time polymerase chain reaction. Collagen substrate caused a reduced swelling ratio compared with the control and gelatin groups (P < 0.05). Compared with other groups, collagen had potential to improve mechanical strength and generate porous membrane structure. The addition of collagen (4‐fold) and gelatin (1.5‐fold) increased cell proliferation rate compared with the control (P < 0.05). Biochemical analysis and Alizarin red S staining showed that collagen‐induced osteogenesis by induction of alkaline phosphatase and matrix mineralization. The expression of osteocalcin and BMP‐2 was increased in cells from the collagen group. As a result, the combination of natural polymers collagen and gelatin with alginate + nano‐silica can increase the osteogenic potential of human osteoblasts.
LY411575, a potent γ‐secretase inhibitor, suppresses osteoclastogenesis in vitro and LPS‐induced calvarial osteolysis in vivo
Authors: Chen Xinwei , Chen Xuzhuo , Zhou Zhihang , Qin An , Wang Yexin , Fan Baoting , Xu Weifeng , Zhang Shanyong 
Published: April 2019

AbstractA series of osteolytic bone diseases are usually related to excessive bone resorption and osteoclast formation. Thus, agents or drugs which can target osteoclast development and attenuate bone loss are potentially considerable in preventing and treating of bone lytic diseases. In recent years, many studies have reported that Notch signaling has substantial impacts on the process of osteoclast differentiation, maturation, and bone destruction. In the present study, we showed that LY411575, a γ‐secretase inhibitor, could potently suppress osteoclast differentiation, osteoclast‐specific gene expression, and bone resorption via suppressing Notch/HES1/MAPK (ERK and p38)/Akt‐mediated NFATc1 induction in vitro. Consistent with in vitro results, LY411575 exhibited protective effects in lipopolysaccharides‐induced calvarial bone destruction in vivo. Collectively, these results indicate that LY411575 may have therapeutic potential in the treatment of osteoclast‐mediated osteolytic bone diseases.
miR‐192/215‐5p act as tumor suppressors and link Crohn's disease and colorectal cancer by targeting common metabolic pathways: An integrated informatics analysis and experimental study
Authors: Zhao Hu , Chen Junqiu , Chen Jin , Kong Xuhui , Zhu Hehuan , Zhang Yongping , Dong Huiyue , Wang Jie , Ren Qun , Wang Qinghua , Chen Shushang , Deng Zhen , Chen Zhan , Cui Qiang , Zheng Junqiong , Lu Jun , Wang Shuiliang , Tan Jianming 
Published: April 2019

AbstractMicroRNAs have emerged as key regulators involved in a variety of biological processes. Previous studies have demonstrated that miR‐192/215 participated in progression of Crohn's disease and colorectal cancer. However, their concrete relationships and regulation networks in diseases remain unclear. Here, we used bioinformatics methods to expound miR‐192/215‐5p macrocontrol regulatory networks shared by two diseases. For data mining and figure generation, several miRNA prediction tools, Human miRNA tissue atlas, FunRich, miRcancer, MalaCards, STRING, GEPIA, cBioPortal, GEO databases, Pathvisio, Graphpad Prism 6 software, etc
. are extensively applied. miR‐192/215‐5p were specially distributed in colon tissues and enriched biological pathways were closely associated with human cancers. Emerging role of miR‐192/215‐5p and their common pathways in Crohn's disease and colorectal cancer was also analyzed. Based on results derived from multiple approaches, we identified the biological functions of miR‐192/215‐5p as a tumor suppressor and link Crohn's disease and colorectal cancer by targeting triglyceride synthesis and extracellular matrix remodeling pathways.
The climatology and interannual variability of cyclone tracks in the National Center for Environmental Prediction's climate forecast system model for the Southern Hemisphere
Authors: Eichler Timothy P. , Market Patrick 
Published: April 2019

AbstractEvaluating cyclone tracks in climate models represents an excellent way to evaluate their ability to simulate synoptic‐scale phenomena. Cyclone tracks were generated from two free‐runs from the National Centers for Environmental Prediction Climate Forecast System (CFSv1) model for the Southern Hemisphere (SH), and compared with cyclone tracks generated from CFS reanalysis and ERA Interim data from 1979 to 2016. It is demonstrated that CFSv1 is capable of simulating realistic SH cyclone track climatology for both intensity and frequency. The CFSv1's ability to capture interannual variability is also highlighted. Specifically, the impacts of the Antarctic Oscillation (AAO), El Niño/Southern Oscillation (ENSO), and the Indian Ocean Dipole (IOD) on cyclone track frequency and intensity were assessed. The CFSv1 exhibits an annular structure in frequency and intensity in response to the AAO. For the reanalysis data, AAO cyclone frequency is less annular in the South Pacific especially during Austral Summer, possibly due to a positive trend in the AAO in recent decades. To test this, a reconstruction of cyclone tracks for ERA40 data from 1958 to 2001 produces a more annular structure. The response of cyclone tracks due to ENSO is fairly robust, with the reanalysis datasets and one member of the CFSv1 producing a pattern of cyclone variability consistent with the Pacific South American teleconnection pattern. In contrast, the cyclone frequency and intensity response to the IOD shows little agreement between reanalysis and CFSv1. An examination of 200‐hPa stream function supports the CFS model producing a teleconnection response to ENSO but not the IOD, possibly due to anomalous heating generated from the IOD being too small. Our results suggest that assessing interannual variability of cyclone tracks in current state‐of‐the‐art models be done with large‐number ensembles when possible, especially when considering sensitivity to initial conditions and the magnitude of external forcing.
Antecedents and Consequences of Creativity in Teams: When and How Leader Humility Promotes Performance via Team Creativity
Authors: Wang Xing , Li Hongli , Yin Hongbiao 
Published: April 2019

AbstractThe antecedents of team creativity and their effects on team task performance are explored in this study, with a particular focus on how leader humility promotes team creativity and when team creativity can be converted into performance. Hypotheses were tested via a multiple‐source and time‐lagged study with 341 employees and 104 teams from five different organizations in China. The results showed that leader humility promotes team creativity through team creative efficacy, and leader conscientiousness moderates this indirect effect. Furthermore, team creativity is more positively related to team task performance when teams are more future oriented. The theoretical contributions and management significance of these findings are discussed, followed by a discussion of limitations and directions for future research.
Under drought conditions NaCl improves the nutritional status of the xerophyte Zygophyllum xanthoxylum but not of the glycophyte Arabidopsis thaliana
Authors: Wang Wen-Ying , Chai Wei-Wei , Zhao Chang-Yu , Rowland Owen , Wang Bao-Shan , Song Xin , Liu Ya-Qi , Ma Qing , Wang Suo-Min 
Published: April 2019

AbstractZygophyllum xanthoxylum is a salt‐accumulating xerophytic species with excellent adaptability to adverse environments. Previous studies demonstrated that Z. xanthoxylum absorbs a great quantity of Na+ as an osmoregulatory substance under arid conditions. To investigate the nutritional status of Z. xanthoxylum in comparison with a typical glycophyte, Arabidopsis thaliana, seedlings were exposed to NaCl (50 mM for Z. xanthoxylum and 5 mM for A. thaliana), osmotic stress (–0.5 MPa), and osmotic stress combined with the NaCl treatment. Compared to the control, NaCl treatment or osmotic stress significantly increased Na+ concentration in leaves and roots of Z. xanthoxylum, but not of A. thaliana. Under osmotic stress, the addition of NaCl significantly increased Na+ concentration in leaves and roots of Z. xanthoxylum, resulting in improved biomass and tissue water content. However, such changes were not observed in A. thaliana. Compared to the control, K+ concentrations in leaves and roots remained unchanged in Z. xanthoxylum when exposed to osmotic stress, with or without additional 50 mM NaCl. In contrast, significant reductions in shoot K+ concentrations of A. thaliana were observed under osmotic stress alone or when combined with 5 mM NaCl. Moreover, NaCl alone or when combined with osmotic stress enhanced the accumulation of N, P, Fe, Si, Ca2+, and Mg2+ in Z. xanthoxylum, but did not cause such nutritional changes in A. thaliana. Compared to the glycophyte A. thaliana, Z. xanthoxylum could accumulate Na+ and maintain the stability of nutritional status at a relatively constant level to cope with drought stress.
Minimizing blind men effect in strategic group research: Visualizing complex turbulent markets
Authors: Rebière Philippe , Mavoori Hareesh 
Published: April 2019

AbstractIncreasing complexity and turbulence of modern markets calls for nonstatic multitheoretical/empirical approaches with intrinsic triangulation and intuitive strategic cluster visualization to minimize the “blind men effect” to offer unbiased insights for various stakeholders: corporate strategic managers, policy researchers, and market legislators. This study presents a refined framework for multi‐time‐point dynamic analysis that integrates and superposes multiple dimensions of strategic flexibility, agility, and orientation for cross‐validated insights. It also addresses long‐standing critical debates on strategic group theory via the metaphor of the blind men and the elephant justifying the need for an in‐depth, multiperspective approach. Our approach reveals the evolution of the market structure (strategic and competitive dynamics) of the French pharmaceutical market over time by mapping and interpreting strategic movements over a turbulent time period.
Rapid in‐field failures following adjuvant radiation for buccal squamous cell carcinoma
Authors: Factor Oren , Su William , Lazarev Stanislav , Miles Brett , Genden Eric , Sharma Sonam , Gupta Vishal , Misiukiewicz Krzysztof , Bakst Richard L. 
Published: April 2019

Objectives/HypothesisSquamous cell carcinoma originating in the buccal mucosa and retromolar trigone (RMT) have historically poor outcomes. Difficulties in discriminating tumor origin often result in these subsites being combined in surgical and pathological reports. We aimed to determine if making this anatomical distinction has implications for treatment design and clinical outcomes.Study DesignRetrospective case series.MethodsWe identified 27 tumors from either the buccal mucosa patients or RMT patients who underwent surgery followed by radiation. For patients who developed a local failure, we fused the pretreatment imaging, simulation computed tomography, and follow‐up imaging to determine the location of failures relative to the radiation field. We calculated the 2‐year locoregional control and 2‐year disease‐free survival.ResultsThe median time from surgery to radiation was 50 days (range, 32–133 days). The 2‐year locoregional control for buccal mucosa versus RMT, respectively, were 35.9% versus 68.4% (P = .252). The 2‐year disease‐free survival rates were 32.7% versus 68.4%, respectively (P = .196). The median times to failure were 12.00 months (range, 4.9–115.0 months) versus 18.5 months (range, 4.5–61.0 months), respectively. All buccal mucosa failures occurred within the high‐dose planning target volume, with a median dose of 60 Gy within the failure region. Following locoregional failure, 10 of the 12 patients have died, with a median time from local failure to death of 3.6 months (range, 1–17.6 months).ConclusionsSquamous cell carcinomas of the buccal mucosa appear to have a poor prognosis characterized by rapid in‐field failure. Therefore, differentiating tumor origin may be important for prognostication and treatment.Level of Evidence3 Laryngoscope, 130:413–417, 2020
Chronic renal dysfunction, proteinuria, and risk of Parkinson's disease in the elderly
Authors: Nam Ga Eun , Kim Nan Hee , Han Kyungdo , Choi Kyung Mook , Chung Hye Soo , Kim Jin Wook , Han Byoungduck , Cho Sung Jung , Jung Seung Jin , Yu Ji Hee , Park Yong Gyu , Kim Seon Mee 
Published: April 2019

AbstractBackgroundThe roles of chronic kidney disease and proteinuria in the development of Parkinson's disease have not been widely studied. The objective of this study was to examine the associations of chronic renal dysfunction and proteinuria with the risk of PD in older adults using cohort data of the whole South Korean population.MethodsWe included 3,580,435 individuals aged ≥65 years who had undergone health checkups provided by the National Health Insurance Service of South Korea between 2009 and 2012 and were followed until 2015. Multivariable Cox proportional hazards regression models were performed.ResultsDuring a mean follow‐up of 5.2 ± 1.3 years, 30,813 individuals (0.86% of the total population) developed PD. Lower estimated glomerular filtration rate and a higher degree of proteinuria on a dipstick test were associated with higher incidence probability of PD (log‐rank P < 0.001). In Cox regression models, chronic renal dysfunction graded by estimated glomerular filtration rate (mL/min/1.73 m2) was associated with increased risk of PD after adjusting for potential confounding variables; hazard ratio (95% confidence interval) was 1.13 (1.10–1.17) for estimated glomerular filtration rate 60–90, 1.36 (1.31–1.42) for estimated glomerular filtration rate 30–60, and 1.47 (1.32–1.63) for estimated glomerular filtration rate <30 (P for trend <0.001). Proteinuria ≥1+ was also associated with increased risk of PD development (hazard ratio, 1.12; 95% confidence interval, 1.06–1.18). Coexistence of chronic kidney disease and proteinuria showed an increased hazard ratio of 1.33 (95% confidence interval, 1.23–1.45) for PD occurrence.ConclusionsOur findings suggest that chronic renal dysfunction and dipstick‐positive proteinuria may be independent risk factors for the development of PD in older adults. © 2019 International Parkinson and Movement Disorder Society
Whole genome sequencing reveals novel IGHMBP2 variant leading to unique cryptic splice‐site and Charcot‐Marie‐Tooth phenotype with early onset symptoms
Authors: Cassini Thomas A. , Duncan Laura , Rives Lynette C. , Newman John H. , Phillips John A. , Koziura Mary E. , Brault Jennifer , Hamid Rizwan , Cogan Joy ,   Undiagnosed Diseases Network
Published: April 2019

AbstractBackgroundRare variants (RV) in immunoglobulin mu‐binding protein 2 (IGHMBP2) [OMIM 600502] can cause an autosomal recessive type of Charcot‐Marie‐Tooth (CMT) disease [OMIM 616155], an inherited peripheral neuropathy. Over 40 different genes are associated with CMT, with different possible inheritance patterns.Methods and ResultsAn 11‐year‐old female with motor delays was found to have distal atrophy, weakness, and areflexia without bulbar or sensory findings. Her clinical evaluation was unrevealing. Whole exome sequencing (WES) revealed a maternally inherited IGHMBP2 RV (c.1730T>C) predicted to be pathogenic, but no variant on the other allele was identified. Deletion and duplication analysis was negative. She was referred to the Undiagnosed Disease Network (UDN) for further evaluation.Whole genome sequencing (WGS) confirmed the previously identified IGHMBP2 RV and identified a paternally inherited non‐coding IGHMBP2 RV. This was predicted to activate a cryptic splice site perturbing IGHMBP2 splicing. Reverse transcriptase polymerase chain reaction (RT‐PCR) analysis was consistent with activation of the cryptic splice site. The abnormal transcript was shown to undergo nonsense‐mediated decay (NMD), resulting in halpoinsufficiency.ConclusionThis case demonstrates the deficiencies of WES and traditional molecular analyses and highlights the advantages of utilization of WGS and functional studies.
The behaviour of near‐surface soils through ultrasonic near‐surface inundation testing
Authors: Taylor Oliver‐Denzil S. , Cunningham Amy L. , Walker Robert E. , McKenna Mihan H. , Martin Kathryn E. , Kinnebrew Pamela G. 
Published: April 2019

ABSTRACTSeismometers installed within the upper metre of the subsurface can experience significant variability in signal propagation and attenuation properties of observed arrivals due to meteorological events. For example, during rain events, both the time and frequency representations of observed seismic waveforms can be significantly altered, complicating potential automatic signal processing efforts. Historically, a lack of laboratory equipment to explicitly investigate the effects of active inundation on seismic wave properties in the near surface prevented recreation of the observed phenomena in a controlled environment. Presented herein is a new flow chamber designed specifically for near‐surface seismic wave/fluid flow interaction phenomenology research, the ultrasonic near‐surface inundation testing device and newvp‐saturation andvs‐saturation relationships due to the effects of matric suction on the soil fabric.
Colonial and modern fisheries in the Indian River Lagoon, Florida, USA
Authors: Fradkin Arlene 
Published: April 2019

AbstractThe Indian River Lagoon is a narrow estuary extending 251 km (156 mi) along the Atlantic coast of Florida. One of the most biodiverse waterways in North America, this aquatic ecosystem is currently home to more than 4,000 plant and animal species, including approximately 700 fish species. According to archaeological faunal evidence from a mid‐18th‐century colonial settlement in the northern Indian River Lagoon region, this estuary also provided an abundance of wild animal resources in the past. The colonists relied heavily upon the lagoon as indicated by the predominance of ray‐finned fishes in the examined faunal samples. A comparison between particular fish species represented in the archaeological colonial record and those currently found in the lagoon today demonstrates that these fishes were comparable in relative frequency and size.
The contagion of optimism: The relationship between patient optimism and palliative care clinician overestimation of survival among hospitalized patients with advanced cancer
Authors: Ingersoll Luke T , Alexander Stewart C. , Ladwig Susan , Anderson Wendy , Norton Sally A. , Gramling Robert 
Published: April 2019

AbstractObjectiveClinicians frequently overestimate survival time among seriously ill patients, and this can result in medical treatment at end of life that does not reflect the patient's preferences. Little is known, however, about the sources of clinicians' optimistic bias in survival estimation. Related work in social networks and experimental psychology demonstrates that psychological states—such as optimism—can transfer from one person to another.MethodsWe directly observed and audio recorded 189 initial inpatient palliative care consultations among hospitalized patients with advanced cancer. Patients self‐reported their level of trait optimism and expectations for survival prognosis prior to the palliative care consultation, and the palliative care clinicians rated their expectations for the patient's survival time following the initial conversation with the patient. We followed patient mortality for 6 months.ResultsPatient optimism was associated with clinician overestimation of their survival in a dose–response relationship. Clinicians were approximately three times as likely to overestimate the survival of patients endorsing both high trait optimism and optimistic ratings of their survival time compared with neither (OR: 2.95; 95% CI: 1.24‐7.02). This association was not attenuated by adjustment for age, gender, race, ethnicity, education, income, cancer type, functional status, quality of life, or white blood cell count (ORadj: 3.45; 95% CI: 1.24‐9.66).ConclusionPatients' optimism may have some influence over their clinicians' prognostic judgments.