bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aquaporin Expression in Colonic Mucosal Biopsies From Irritable Bowel Syndrome With Diarrhea
Authors: Camilleri Michael , Carlson Paula , Chedid Victor , Vijayvargiya Priya , Burton Duane , Busciglio Irene 
Published: April 2019

INTRODUCTION:
Aquaporin (AQP) channels are involved in regulating fluid homeostasis in the colon. Several AQP channels were detected in human colon epithelial cells. In a previous study, rats fed 1% (wt/wt) sodium cholate had increased AQP3, 7, and 8 levels, suggesting AQP involvement in bile acid diarrhea (BAD). Our aim was to compare AQP expressions in rectosigmoid mucosal (RSM) biopsies from patients with irritable bowel syndrome–diarrhea (IBS-D) (divided into those with normal or high fecal BA excretion) and in patients with IBS-constipation (IBS-C) compared with healthy controls.

METHODS:
In RSM biopsies from 44 patients with IBS-D (with normal (<) or high (>2,337 μmol/48 hours (BAD)) fecal BA excretion), 10 patients with IBS-C, and 17 healthy controls, we measured expressions of AQP1, 3, 7, and 8, with RT-PCR (housekeeper gene GAPDH). We analyzed RNA for expression by RT2-PCR assays, with expression calculated using 2−ΔΔCT-based fold-change. Comparisons of IBS groups were corrected for false detection rate (Bonferroni correction for 12 comparisons; P < 0.0042). AQP protein measurements on biopsies from 3 healthy controls, 3 patients with IBS-D, and 3 patients with BAD were performed by western blots (GAPDH housekeeping protein).

RESULTS:
In RSM from patients with IBS-D (but not IBS-C), mRNA expression of AQP3 was decreased, and AQP7 and 8 were increased relative to controls. Fold differences were not different in IBS-D with or without BAD. Western blots confirmed increased expression of AQP7 and 8 and decreased AQP3 proteins in biopsies from patients with IBS-D compared with controls.

CONCLUSIONS:
Increased AQP7 and 8 and decreased AQP3 expressions in RSM suggest that further studies on AQPs' potential role in the pathophysiology of diarrhea in IBS-D are warranted.
The Politics of Property Rights: The Case of Akyem Abuakwa, Ghana (1912–1943)
Authors: Ofosu-Mensah Emmanuel Ababio 
Published: April 2019

Abstract
Some political historians, such as Rathbone and Firmin-Sellers, have argued that some traditional rulers under colonial rule introduced new property rights by reinventing tradition and enforcing them within their traditional states to satisfy their own parochial interest. This article employs archival, secondary, and oral sources to critically clarify the exceptional case of Nana Ofori Atta I’s to put forward a contrary view. It argues that Nana Ofori Atta I, with great political will where his predecessors failed, came up with some pragmatic, practical, and problem-solving measures in order to make the indigenous concept of land ownership beneficial for the larger community.
Kajian Numerik Efektifitas Film Cooling pada Sudu Turbin Gas
Authors: Jamaldi Agus , Effendy Marwan 
Published: April 2019

Penelitian ini bertujuan untuk mengevaluasi penggunaan model turbulensi Detached Eddy Simulation Spallart-Almaras (DES-SA) pada studi numerik tentang sistem pendinginan trailing edge (TE) pada sudu turbin gas. Sebuah desain TE cutback cooling dengan susunan staggered pin-fin dipilih sebagai spesimen pengujian berbasis simulasi. Tiga parameter penting seperti discharge coefficient (CD), adiabatic film cooling effectiveness (ηaw), dan shedding frequency (fs) menjadi fokus utama dalam penyelidikan kinerja sistem pendinginan TE sudu turbin gas. Penelitian dilakukan pada variasi tiga blowing ratios (M) yaitu 0,5; 0,8; dan 1,1. Hasil riset menunjukkan bahwa nilai CD yang diperoleh dari hasil simulasi memiliki kesesuaian trend jika dibandingkan dengan data peneliti terdahulu, dimana nilai CD sedikit meningkat seiring dengan M yang semakin besar. Penyelidikan terkait ηaw yang terjadi pada permukaan adiabatic wall menunjukkan bahwa nilainya konsisten dengan data penelitian yang terdahulu, baik secara eksperimen maupun simulasi. Frekuensi aliran vorteks (fs) berturut-turut 2043, 2323, dan 1976 Hz untuk masing-masing blowing ratios 0,5; 0,8; dan 1,1.
A proposed image-based detection of methamidophos pesticide using peroxyoxalate chemiluminescence system
Authors: Juachon Maria Janine , Regala Justine Grace , Marquez John Matthew , Bailon Mark Xavier 
Published: April 2019

AbstractPesticides pose a serious public health risk due to their toxicity, such as in the case of the widely distributed organophosphorus pesticide methamidophos. There is a strong need to develop a simple, rapid, and cost-effective method of detecting methamidophos residues; thus, this study proposes the TCPO-Rubrene-H2O2 chemiluminescence (CL) system as a means of pesticide detection via quenching effect. The results show that the methamidophos concentration is inversely proportional to the CL system's light output as confirmed through fluorescence spectroscopy and Batch Measure Macro (BMM) analysis. The light intensity differences were correlated with the methamidophos concentration with both methods showing linear trends. Both the digital camera and the smartphone camera BMM analyses displayed good sensitivity, with respective detection limits of 1.6 μg/mL and 1.0 μg/mL and respective quantitation limits of 5.0 μg/mL and 3.0 μg/mL. Both also showed good linearity within the 100-10000 μg/mL range, suggesting viability as alternatives to the fluorescence spectrometer; however, the light intensity difference values per pesticide concentration of both camera systems were significantly different from one another owing to differences in camera features.
Loneliness in the context of quality of life of nursing home residents
Authors: Trybusińska Dorota , Saracen Agnieszka 
Published: April 2019

Abstract

Background
Numbers of the elderly have been on a steady increase both in Poland and other countries of the world. As they age, their health declines and they need help with their housekeeping. This, coupled with the transformation of intergenerational into single-generation or nuclear family structures, causes a markedly rising demand for institutional care. Holistic care of an elderly nursing home resident requires a comprehensive approach and consideration for their feelings. Loneliness and solitude are increasingly common among these feelings, undoubtedly affecting quality of life.

Method
250 elderly residents of seven nursing home situated in Mazovia, Poland, have been examined using: De Jong Gierveld Loneliness Scale, WHOQOL-BREF Questionnaire, Basic Hope Scale (BHI-12), Satisfaction with Life Scale (SWLS), Acceptance of Illness Scale (AIS).

Results
Loneliness affects nearly 40% residents of the homes surveyed. Quality of their residents’ lives is reduced. Relations with their families and levels of motor efficiency imply a sense of loneliness. Degrees of illness acceptance, ability to adjust to change, and life satisfaction influence the level of loneliness felt.

Conclusion
40% of nursing home residents exhibit a sense of loneliness, while the greater loneliness and solitude, the lower the quality of life.
Discovery of N-methylpiperazinyl flavones as a novel class of compounds with therapeutic potential against Alzheimer’s disease: synthesis, binding affinity towards amyloid β oligomers (Aβo) and ability to disrupt Aβo-PrPC interactions
Authors: Matos Ana M. , Man Teresa , Idrissi Imane , Souza Cleide C. , Mead Emma , Dunbar Charlotte , Wolak Joanna , Oliveira Maria C. , Evans David , Grayson James , Partridge Benjamin , Garwood Claire , Ning Ke , Sharman Gary , Chen Beining , Rauter Amélia P. 
Published: April 2019

Abstract
With no currently available disease-modifying drugs, Alzheimer’s disease is the most common type of dementia affecting over 47 million people worldwide. In light of the most recent discoveries placing the cellular prion protein (PrPC) as a key player in amyloid β oligomer (Aβo)-induced neurodegeneration, we investigated whether the neuroprotective potential of nature-inspired flavonoids against Aβ-promoted toxicity would translate into the ability to disrupt PrPC-Aβo interactions. Hence, we synthesized a small library of flavones and studied their binding affinity towards Aβo by STD-NMR. C-glucosyl flavones exhibited improved binding affinity with morpholine, thiomorpholine or N-methylpiperazine rings attached to the flavone skeleton in ring B para position. Moreover, a N-methylpiperazinyl flavone displayed suitable physicochemical properties and optimal water solubility even without the sugar moiety, and a high interaction with Aβo involving the whole flavone core. Its C-glucosyl derivative, was, however, the best compound to inhibit PrPC-Aβo interactions in a dose-dependent manner, with 41 % of inhibition capacity at 10 μM. The potential of C-glucosyl flavones and their aglycones as protein-protein interaction inhibitors able to tackle PrPC-Aβo interactions is here presented for the first time, and supports this class of compounds as new prototypes for further development in the treatment of Alzheimer’s disease.
The research reactor TRIGA Mainz – a strong and versatile neutron source for science and education
Authors: Eberhardt Klaus , Geppert Christopher 
Published: April 2019

Abstract
The TRIGA Mark II-reactor at the Johannes Gutenberg University Mainz (JGU) is one of three research reactors in Germany. The TRIGA Mainz became first critical on August 3rd, 1965. It can be operated in the steady state mode with a maximum power of 100 kWth and in the pulse mode with a peak power of 250 MWth and a pulse length of 30 ms. The TRIGA Mainz is equipped with a central thimble, a rotary specimen rack, three pneumatic transfer systems, four beam tubes, and a graphite thermal column. The TRIGA Mainz is intensively used both for basic and applied research in nuclear chemistry and nuclear physics. Two sources for ultra-cold neutrons (UCN) are operational at two beam ports. At a third beam port a Penning-Trap for highly precise mass measurements of exotic nuclides is installed. Education and training is another main field of activity. Here, various courses in nuclear and radiochemistry, reactor operation and reactor physics are held for scientists, advanced students, engineers, and technicians utilizing the TRIGA Mainz reactor.
Educational interventions to improve medical students’ knowledge of acute pain management: a randomized study
Authors: Poulsenª Mette , Friesgaard Kristian Dahl , Seidenfaden Sophie , Paltved Charlotte , Nikolajsen Lone 
Published: April 2019

Abstract
It has been consistently documented that the treatment of acute pain is inadequate. Education of medical students is an obvious strategy to improve this. We therefore conducted a study in which 217 medical students were randomized into one of three groups: a control group (no intervention) and two intervention groups (education with e-learning alone or e-learning combined with simulation-based training). We hypothesized that the combined intervention would be superior to no intervention and e-learning alone. All students completed the same multiple choice questionnaire twice with an interval of approximately 1 week. During this 1-week interval, students in the two intervention groups completed either an 45-min interactive case-based e-learning program, or the e-learning program and a simulation-based training. We showed that the theoretical knowledge about treatment of acute pain increased in both intervention groups but students who received the combined intervention felt more confident in the future handling of patients.
Cognitive diagnosis of cultural and rural tourism convergence
Authors: Liu Yanjuan 
Published: April 2019

Abstract
Neural networks are widely used in the field of cognitive diagnosis. Cognitive diagnosis can diagnose the subjects’ knowledge of cognitive attributes according to their responses, so as to obtain the specific cognitive status of the subjects and provide remedial measures. The studies on the convergence of cultural industry and tourism industry are emerging, but the theoretical system needs to be improved. The research on the convergence mechanism between cultural industry and tourism industry can complement each other on the basis of independent theoretical system, which establishes relationship between the two theoretical systems. Based on the adaptive neural network algorithm and from the perspective of blockchain, this study takes cultural industry and rural tourism industry as examples to diagnose the industry convergence of rural cultural industry and rural tourism industry development, which will further consolidate the theoretical basis for the convergence and development of tourism industry and cultural industry, as well as contribute to promoting development of industry convergence.
Cognition of nurses in neurology department on rehabilitation nursing
Authors: Liu Qie , Xu Xin 
Published: April 2019

Abstract
Stroke has become a major disease seriously threating human health due to its high morbidity, mortality and disability. Rehabilitation nursing care for stroke patients has always been a key part of clinical care. The neurological nursing managers should pay high attention to the issue about how to more effectively improve the level of nurses’ rehabilitation nursing on stroke patients. Therefore, this paper investigates the current cognition of neurological nurses about stroke knowledge, attitude and behaviour, and then analyses the factors affecting the knowledge, attitude and behaviour of stroke in the nurses, in order to provide better nursing services for stroke patients, and improve their nursing quality. The findings show that the different cognitions of nurses about their role have different effects on the knowledge, attitudes and behavioural levels of the neurological nurses; the nurses with more types of roles have better knowledge and behavioural levels of stroke.
Influence of cognitive neuroscience on contemporary philosophy of science
Authors: Ren Fang 
Published: April 2019

Abstract
The study of contemporary philosophy of science based on cognitive neuroscience has strongly promoted the philosophy study of brain cognitive problems. It has pointed out the research direction for human to explore the relationship between the traditional mind and brain while systematically reflecting and investigating the theoretical basis and research method of cognitive neuroscience. Therefore, this study explores the influence and the significance of cognitive neuroscience on contemporary philosophy of science.
Socialinio atvirumo kilmė ir prasmė Bergsono ir Popperio mąstyme
Authors: Aleksandravičius Povilas 
Published: April 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Straipsnyje analizuojama socialinio atvirumo kilmė ir prasmė H. Bergsono ir K. R. Popperio mąstyme, siekiant atskleisti pamatinę atviros visuomenės sąvokos reikšmę jos kūrėjų darbuose. Pirmoji straipsnio dalis yra skirta H. Bergsono uždaros visuomenės formavimosi tyrimui, atspirties tašku pasirinkus žmogaus reakcijos į mirtį analizę. Antroji dalis atskleidžia H. Bergsono teigiamą socialinio atvirumo procesą, kurio antropologinis pamatas – instinkto konversija į intuiciją arba proto realizuojamas kontaktas su gyvybinio polėkio principu. Trečiojoje dalyje yra tiriamas K. R. Popperio uždaros ir atviros visuomenės konceptas H. Bergsono filosofijos kontekste.
Future, or On the Redemption of Nature after Schelling and Nietzsche
Authors: Corriero Emilio Carlo 
Published: April 2019

[full article, abstract in English; abstract in Lithuanian]
It is starting from the role recognized and attributed to nature by Schelling and Nietzsche that one understands the renewed relationship between being and time at the basis of the possibility for the new beginning of Western philosophy, prophesized by Heidegger in 1936. For both, the possibility of the very future passes by the necessary redemption of the past (that is an extreme liberation from its conceptual hypostatization) through a form of love for the All, which is possible to recognize only with a philosophy of nature that is able to show the “unprethinkable” ground of being and its eternal dynamics as potential potentiae. Only on the basis of this potentia potentiae of the “unprethinkable” past, the “coming event” of the future becomes possible, as well as that renewed relation between time and being, which permits a new beginning for Western philosophy.
A hirtelen halláscsökkenés javulásában szerepet játszó prognosztikai faktorok vizsgálata
Authors: Kovács Márton , Uzsaly János , Bodzai Gréta , Harmat Kinga , Németh Adrienne , Gerlinger Imre , Bakó Péter 
Published: April 2019

Abstract: Sudden sensorineural hearing loss is defined as a greater than 30 dB deterioration in at least 3 consecutive frequencies occurring within 72 hours. The disease is mostly idiopathic and needs an urgent treatment. Between 01. 01. 2015 and 31. 12. 2016, 149 patients with sudden hearing loss were admitted to the Department of Otorhinolaryngology, University of Pécs. The epidemiological data, the prognostic factors and the outcome of the treatment were retrospectively analyzed. Isolated high frequency (p = 0.012) and less severe hearing loss (p<0.001), older age (p = 0.005), comorbodities like cardiovascular disease (p = 0.009) and diabetes (p = 0.029) were found as negative prognostic factors. Time of introduction of the treatment, gender, and side of the affected ear did not influence the outcome. Our finding was mainly congruent to the literature. Orv Hetil. 2019; 160(18): 687–693.
Model Tabligh Salmanitb.com dalam Menyajikan Berita Islami
Authors: Hilman M. Ambang Fajar , Sumijati Sitty , Bahrudin Bahrudin 
Published: April 2019

This study describes the application model tabligh SalmanITB.com in presenting Islamic news. This research is a qualitative-descriptive research using case study method. The theory used is journalistic theory or news presentation consisting of coverage, writing, and dissemination of news with materials. After the research, it was found that the application of Tabligh SalmanITB.com in presenting Islamic news refers to three main processes (coverage, writing, and dissemination of news) as the theory of news presentation, evidenced by sampling news on the materials needed. Based on this finding, it can be concluded that SalmanITB.com's tabligh model in presenting Islamic news has been in accordance with the rules of the news presentation process.
Tulisan ini mendeskripsikan model penerapan tabligh SalmanITB.com dalam menyajikan berita-berita Islami. Penelitian ini merupakan penelitian kualitatif-deskriptif menggunakan metode studi kasus. Teori yang digunakan adalah teori jurnalistik atau penyajian berita yang terdiri dari peliputan, penulisan, dan penyebarluasan berita. Penerapan tabligh SalmanITB.com dalam menyajikan berita-berita islami mengacu pada tiga proses utama (peliputan, penulisan, dan penyebarluasan berita) sebagaimana teori penyajian berita, dibuktikan dengan pengambilan sampel berita pada materi-materi yang dibutuhkan. Berdasarkan penemuan ini dapat disimpulkan bahwa model tabligh SalmanITB.com dalam menyajikan berita islami telah sesuai dengan aturan proses penyajian berita.
Pola Tabligh Organisasi Jamiyah Nurul Iman Bandung
Authors: Permana Yoga Hadi , Abidin Zainal 
Published: April 2019

The purpose of this paper is to know the tabligh pattern applied by the Islamic Nurul Iman Bandung with elements contained in it’s religious activities. This research uses descriptive analysis method with qualitative approach. The data collected by observation and interview with related parties, such as chairman, secretary, preacher, and member in jamiyah organization Nurul Iman Bandung, and supported by literature review. The results showed that the pattern of tabligh in the organization Jamiyah Nurul Iman Bandung can be seen from the activities, material patterns, patterns of methods and communication patterns that occur in the activities tabligh Jamiyah Nurul Iman Bandung. Researchers found that communication in the activities of tabligh more invites and influences jama'ah to realize the messages of Islam submitted preachers through the actions of preachers and supported by activities tabligh within the organization Jamiyah Nurul Iman.
Tujuan tulisan ini untuk mengetahui pola tabligh yang diterapkan oleh organisasi jamiyah Nurul Iman Kota Bandung melalui unsur-unsur yang terkandung dalam kegiatan-kegiatan keagamaan. Penelitian ini menggunakan metode analisis deskriptif dengan pendekatan kualitatif, Data diperoleh melalui observasi dan wawancara dengan pihak terkait, seperti ketua, sekretaris, mubaligh, serta anggota dalam organisasi jamiyah Nurul Iman Kota Bandung, dan ditunjang oleh tinjauan pustaka. Hasil penelitian menunjukkan bahwa pola tabligh dalam organisasi Jamiyah Nurul Iman Bandung dapat dilihat dari kegiatan, pola materi, pola metode serta pola komunikasi yang terjadi dalam aktivitas tabligh organisasi jamiyah Nurul Iman Kota Bandung. Peneliti menemukan bahwa, komunikasi dalam kegiatan tabligh lebih banyak mengajak serta mempengaruhi jama’ah untuk merealisasikan pesan-pesan keislaman yang disampaikan mubaligh melalui tindakan-tindakan yang dilakukan mubaligh serta didukung oleh kegiatan-kegiatan tabligh dalam organisasi Jamiyah Nurul Iman.
Gülten Dayıoğlu’nun Gezi Kitapları Üzerine Bir Değerlendirme
Authors: TEKŞAN Keziban , AKKAYA Sultan Ecem , ÇİNPOLAT Enes 
Published: April 2019

Çocukluk, insan hayatının en önemli dönemlerinden
biridir. Çünkü kişiliğin temelleri bu evrede atılır. Bu gelişim sürecinde çocuk
edebiyatı ürünleri büyük önem taşır. Özellikle de disiplinler arası etkileşime
izin veren, gözleme ve deneyimlere dayanan gezi türüne büyük görev düşmektedir.
Bu çalışmada bilgilendirici/öğretici metin türleri arasında yer alan gezi
türünün çocuk gelişimine katkısı üzerinde durulmaktadır. Ayrıca yazarlık
hayatına başladığı günden bu yana hedef kitlesi yalnızca çocuklar olan Gülten
Dayıoğlu’nun gezi kitapları, taşıdığı nitelikler ve çocuklara sağlayacağı
katkılar yönünden incelenmiştir. Çalışma, nitel araştırma türlerinden temel
nitel araştırma (basic qualitative research) çalışmasıdır. Verilerin toplanmasında doküman
incelemesi yapılmıştır. Verilerin
analizinde betimsel analiz yönteminden faydalanılmıştır. Kitapların
incelenmesi Arıcı, Ungan ve Şimşek’in (2016) çocuklar için yazılan veya tavsiye
edilen gezi yazılarında aranılması gereken niteliklere göre yapılmıştır. Çalışmada
Gülten Dayıoğlu’nun “Kafdağı’na Yolculuk”, “Okyanuslar Ötesine Yolculuk”,
“Bambaşka Bir Dünya Amerika’ya Yolculuk”, “Efsaneler Ülkesi Çin’e Yolculuk”,
“Kangurular Ülkesi Avusturalya’ya Yolculuk”, “Kenya’ya Yolculuk”, “Mısır’a
Yolculuk” ve “Meksika’ya Yolculuk” adlı kitapları incelenmiştir.
Değerlendirmeler ışığında adı geçen kitapların öğrencilerin bilgilerini, düşüncelerini, gözlem becerilerini
geliştireceği ve onlara farklı kültürleri tanıtacağı düşünülmektedir.