bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safe Handling of Hazardous Drugs: ASCO Standards
Authors: Celano Paul , Fausel Christopher A. , Kennedy Erin B. , Miller Tim M. , Oliver Thomas K. , Page Ray , Ward Jeffery C. , Zon Robin T. 
Published: January 2019

PURPOSE To provide 2019 ASCO standards on the safe handling of hazardous drugs. METHODS An Expert Panel was formed, and a systematic review of the literature on closed system transfer devices was performed to May 2017 using PubMed. The Cochrane Database of Systematic Reviews, PubMed, and Google Scholar were used to search for studies of medical surveillance and external ventilation/health effects of exposure to vapors to November 2017. Available standards were considered for endorsement. Public comments were solicited and considered in preparation of the final manuscript. RESULTS The search for primary research found no studies that addressed health outcomes as they relate to the identified interventions of interest. The ASCO Expert Panel endorses the best practices for safe handling of hazardous drugs as issued by the Occupational Safety and Health Administration, US Pharmacopeia Chapter 800, and Oncology Nursing Society with clarifications in four key areas: medical surveillance, closed system transfer devices, external ventilation of containment secondary engineering controls or containment segregated compounding areas, and alternative duties. CONCLUSION The ASCO standards address the need for clear standards concerning safe handling of hazardous oncology drugs. More research is needed in several key areas to quantify the level of risk associated with handling hazardous drugs in current workplace settings where the hierarchy of controls is consistently applied. Additional information is available at www.asco.org/safe-handling-standards .
Exact Approaches for Network Design Problems with Relays
Authors: Leitner Markus , Ljubić Ivana , Riedler Martin , Ruthmair Mario 
Published: January 2019

In this article we consider the network design problem with relays (NDPR), which gives answers to some important strategic design questions in telecommunication network design. Given a family of origin-destination pairs and a set of existing links these questions are as follows: (1) What are the optimal locations for signal regeneration devices (relays) and how many of them are needed? (2) Could the available infrastructure be enhanced by installing additional links in order to reduce the travel distance and therefore reduce the number of necessary relays?In contrast to previous work on the NDPR, which mainly focused on heuristic approaches, we discuss exact methods based on different mixed-integer linear programming formulations for the problem. We develop branch-and-price and branch-price-and-cut algorithms that build upon models with an exponential number of variables (and constraints). In an extensive computational study, we analyze the performance of these approaches for instances that reflect different real-world settings. Finally, we also point out the relevance of the NDPR in the context of electric mobility.
Increasing the use of simulation in training
Authors: Higginson Helen 
Published: January 2019

The focus of this paper is to explore the role and development of simulated learning within the apprenticeship assistant practitioner foundation degree programme. It will also discuss the challenge of influencing a change in practice within a competency-based learning programme. In order to shape and develop a supportive, effective and indeed inclusive teaching strategy, the use of the simulated learning environment will be incorporated across a number of mandatory non-clinical modules, such as communication, group dynamics and principles of care, among others. The key aims and philosophy behind simulated teaching and learning are to improve competence, communication and confidence and ultimately patient safety within all healthcare environments ( Forrest et al, 2013 ). The aim of this article is: To provide a wider understanding of the simulated learning environment To give an overview of how simulated learning can be incorporated into non-clinical teaching modules To demonstrate how the concept of simulation can widen participation and allow students to experience and flourish in a non-traditional environment.
Lack of care? Women's experiences of maternity bladder management
Authors: Gutiérrez Verónica Blanco , Fader Mandy , Monga Ash , Kitson-Reynolds Ellen 
Published: January 2019

Background A healthy urinary system is vital to every woman's life, and the relationship between childbirth and bladder dysfunction has been well documented in the medical literature. Aims To explore women's bladder care experiences during the antepartum, intrapartum, and postpartum periods. Methods An exploratory, descriptive research study with nine in-depth semi-structured interviews. Findings Thematic analysis showed three themes: ‘muddling through to earn “a badge of honour”’, ‘caring for a baby, but who cares for me?’ and ‘do you speak bladder language?’ with an overarching theme of ‘lack of bladder care’. Women's experiences reflected a lack of understanding, information, and promotion regarding bladder care, aggravated by the use of ambiguous language when professionals communicated with women about bladder health. Conclusions Bladder care was very limited for women during the antepartum, intrapartum and postpartum period although reports of urinary incontinence were frequent. Bladder care could therefore be characterised as ‘lack of bladder care’. Clinicians should become more proactive in delivering information and promoting bladder health during these periods but that attention needs to be paid to communication methods.
Semiotyka dziwactwa
Authors: Hendrykowski Marek 
Published: January 2019

The author assumes that the curiosity is a type of human expression. It can manifest in various languages and people’s behaviors, e.g.: verbal, mimic, gestural, costume and also by props, hairstyles, makeup etc. Regardless of differences between particular manifestations of the curiosity it is always semiotic. Freaks, eccentrics and weirdos disturb human community’s order and call into question established norms. They do that by their specific behaviors, appearances and individualism. They rectify, transform and change the social reality. The artistic curiosity not infrequently turn out to be the metaphor of an individual lifestyle (e.g. Witkacy, Dali). Freaks in the world of culture are not either savages or barbarians. They express themselves as well as they express their distance from the cultural system. In connection to this thesis, the author assumes that the curiosity is culture-producing.
Enhancing the anticoagulant profile of meizothrombin
Authors: Stojanovski Bosko M. , Pelc Leslie A. , Zuo Xiaobing , Pozzi Nicola , Cera Enrico Di 
Published: January 2019

AbstractMeizothrombin is an active intermediate generated during the proteolytic activation of prothrombin to thrombin in the penultimate step of the coagulation cascade. Structurally, meizothrombin differs from thrombin because it retains the auxiliary Gla domain and two kringles. Functionally, meizothrombin shares with thrombin the ability to cleave procoagulant (fibrinogen), prothrombotic (PAR1) and anticoagulant (protein C) substrates, although its specificity toward fibrinogen and PAR1 is less pronounced. In this study we report information on the structural architecture of meizothrombin resolved by SAXS and single molecule FRET as an elongated arrangement of its individual domains. In addition, we show the properties of a meizothrombin construct analogous to the anticoagulant thrombin mutant W215A/E217A currently in Phase I for the treatment of thrombotic complications and stroke. The findings reveal new structural and functional aspects of meizothrombin that advance our understanding of a key intermediate of the prothrombin activation pathway.
Inferential Processes in English and the Question whether English has Modal Particles
Authors: Fischer Kerstin , Heide Maiken 
Published: January 2019

AbstractIn this paper, we ask whether English pragmatic markers may evoke similar inferential processes in discourse as German modal particles, studying alright/all right, already and then in more detail. Moreover, we investigate whether specific formal features are associated with these uses and thus whether there is any evidence for a productive modal particle category that can serve as a guideline for the creation and interpretation of modal particle uses of English pragmatic markers. Our analysis shows that even though evidence for a schematic modal particle construction is not conclusive, modal particle uses of pragmatic markers may be potentially widespread in English, and the inferential processes involved may be similar across languages.
Temperoammonic Stimulation Depotentiates Schaffer Collateral LTP via p38 MAPK Downstream of Adenosine A1 Receptors
Authors: Izumi Yukitoshi , Zorumski Charles F. 
Published: January 2019

We previously found that low-frequency stimulation of direct temperoammonic (TA) inputs to hippocampal area CA1 depotentiates previously established long-term potentiation in the Schaffer collateral (SC) pathway through complex signaling involving dopamine, endocannabinoids, neuregulin-1, GABA, and adenosine, with adenosine being the most distal modulator identified to date. In the present studies, we examined mechanisms contributing to the effects of adenosine in hippocampal slices from male albino rats. We found that extracellular conversion of ATP to adenosine via an ectonucleotidase contributes significantly to TA-mediated SC depotentiation and the depotentiation resulting from block of adenosine transport. Adenosine-mediated SC depotentiation does not involve activation of c-Jun N-terminal protein kinase, serine phosphatases, or nitric oxide synthase, unlike homosynaptic SC depotentiation. Rather, adenosine-induced depotentiation is inhibited by specific antagonists of p38 MAPK, but not by a structural analog that does not inhibit p38. Additionally, using antagonists with relative selectivity for p38 subtypes, it appears that TA-induced SC depotentiation most likely involves p38 MAPK β. These findings have implications for understanding the role of adenosine and other extrahippocampal and intrahippocampal modulators in regulating SC synaptic function and the contributions of these modulators to the cognitive dysfunction associated with neuropsychiatric illnesses.SIGNIFICANCE STATEMENTLow-frequency stimulation of temperoammonic (TA) inputs to stratum lacunosum moleculare of hippocampal area CA1 heterosynaptically depotentiates long-term potentiation of Schaffer collateral (SC) synapses. TA-induced SC depotentiation involves complex signaling including dopamine, endocannabinoids, GABA, and adenosine, with adenosine serving as the most downstream messenger in the cascade identified to date. The present results indicate that TA-induced depotentiation requires intact inputs from entorhinal cortex and that adenosine ultimately drives depotentiation via activation of p38 MAPK. These studies have implications for understanding the cognitive dysfunction of psychiatric illnesses and certain abused drugs.
PKMζ Inhibition Disrupts Reconsolidation and Erases Object Recognition Memory
Authors: Rossato Janine I. , Gonzalez Maria Carolina , Radiske Andressa , Apolinário Gênedy , Conde-Ocazionez Sergio , Bevilaqua Lia R. , Cammarota Martín 
Published: January 2019

Object recognition memory (ORM) confers the ability to discriminate the familiarity of previously encountered items. Reconsolidation is the process by which reactivated memories become labile and susceptible to modifications. The hippocampus is specifically engaged in reconsolidation to integrate new information into the original ORM through a mechanism involving activation of brain-derived neurotrophic factor (BDNF) signaling and induction of LTP. It is known that BDNF can control LTP maintenance through protein kinase Mζ (PKMζ), an atypical protein kinase C isoform that is thought to sustain memory storage by modulating glutamatergic neurotransmission. However, the potential involvement of PKMζ in ORM reconsolidation has never been studied. Using a novel ORM task combined with pharmacological, biochemical, and electrophysiological tools, we found that hippocampal PKMζ is essential to update ORM through reconsolidation, but not to maintain the inactive recognition memory trace stored over time, in adult male Wistar rats. Our results also indicate that hippocampal PKMζ acts downstream of BDNF and controls AMPAR synaptic insertion to elicit reconsolidation and suggest that blocking PKMζ activity during this process deletes active ORM.SIGNIFICANCE STATEMENTObject recognition memory (ORM) is essential to remember facts and events. Reconsolidation integrates new information into ORM through changes in hippocampal plasticity and brain-derived neurotrophic factor (BDNF) signaling. In turn, BDNF enhances synaptic efficacy through protein kinase Mζ (PKMζ), which might preserve memory. Here, we present evidence that hippocampal PKMζ acts downstream of BDNF to regulate AMPAR recycling during ORM reconsolidation and show that this kinase is essential to update the reactivated recognition memory trace, but not to consolidate or maintain an inactive ORM. We also demonstrate that the amnesia provoked by disrupting ORM reconsolidation through PKMζ inhibition is due to memory erasure and not to retrieval failure.
Rethinking Homeless People’s Punishments
Authors: Skolnik Terry 
Published: January 2019

This article argues that we should rethink homeless people’s punishments for violating quality-of-life ordinances. Those ordinances prohibit acts that are deemed to constitute urban nuisances—urban camping, public urination, and sleeping on sidewalks among them. Violating quality-of-life ordinances can result in expensive fines, administrative fees, and civil consequences for unpaid fines. In line with other scholars’ work, this article demonstrates how our current punishment scheme entrenches individuals in homelessness and operates like a self-fulfilling prophecy. Lacking a private property right and stuck in a cycle of homelessness, homeless people will continue to alleviate their needs on public property and be subject to further coercion and punishment. Homeless people’s punishments for violating quality-of-life offenses are also objectionable because they violate three types of proportionality constraints: the gravity of the prohibited conduct, the homeless person’s moral blameworthiness, and their personal situation.
This article proposes an alternate punishment scheme that minimizes the prospect of entrenchment in homelessness and remedies those three proportionality concerns. It argues that the state should adopt a day-fine model for financial penalties, implement criminal justice debt absolution frameworks, and rethink the civil and criminal consequences associated with unpaid fines. A more proportional punishment scheme is neither a solution to the reality of homelessness nor a substitute for the state’s responsibility to ensure better access to housing. However, this article’s proposals can mitigate the gravest consequences associated with homeless people’s punishments, prevent entrenchment in homelessness, and ensure homeless people are treated with greater respect.
Karol Wojtyła ou «Le gothique de l’âme et la renaissance du corps». Un nouvel humanisme venu de Pologne
Authors: Kasprzak Artur Antoni 
Published: January 2019

Few years ago, a poem by Karol Wojtyła, entitled „Przełom”, that is „The Turning Point”, was discovered. Written between 1942 and 1945, the reflection of young seminarian Karol begins with questions, and a personal and very significant answer: „It is thus that the Gothic of the soul and the Renaissance of the body fight in me”. The Gothic aspect indicates the sensitivity to the spiritual world of the future Pope. The Renaissance of the body is linked to its sporting nature and the desire to open to the true relationship with every man, the friendship. This study focuses its research around these two aspects of the internal integration of Karol Wojtyła, showing their development in pastoral and scientific research in the context of its Polish origins.
The Crisis of Social Ties as a Challenge for the Christian Vision of Social Life
Authors: Głąbiński Janusz 
Published: January 2019

The author of this article analyses the crisis of social ties as a huge challenge for the Christian vision of social life. Firstly, he refers to the moral and religious crisis of the post-modern era, and the depreciation of the social status of the human. Then, he presents the uniqueness of human being as well as potentiality. According to the Christian integral anthropology, presented by personalism, man remains a spiritual and material coexistence. In the last part, the author underlines the Christian idea that a society should acknowledge the dignity of each of its members, as well as guarantee the optimal functioning of human communities. Consequently, social procedures and institutions should be preceded by a consensus assuring the ethical minimum. If a society does not accept the fundamental values like: the dignity of every human being, the protection of their life, justice, equality, solidarity, it cannot function, at least not as a community of persons.
Left ventricular untwist in healthy children and adolescents born full-term
Authors: Pavlyukova E. N. , Kolosova M. V. , Unasheva A. I. , Karpov R. S. 
Published: January 2019

The aimof the study is to assess the left ventricle (LV) untwist in healthy children and adolescents born fullterm.Materials and methods.The analysis was carried out in 108 healthy children aged 2 months to 18 years, born full-term. LV untwist is assessed using Speckle Tracking Imaging at the basal and apical level.Results.Four types of LV untwist were identified in children and adolescents. We did not find relation between LV untwist and age, nor with LV index spherical in systole and diastole, LV myocardial mass. The relationship between LV untwisting and LV rotation in systole at basal and apical segments was revealed.Conclusion.The described features of LV loosening are apparently associated with processes of postnatal growth and maturation of heart tissues in children and adolescents.
FACTOR	ANAYSIS	THE	CAUSE	OF	DELAYED	INTERVENTION	WITH	LENGTH	OF STAY	PATIENTS	ADMISSION	IN	EMERGENCY	DEPARTMENT	OF PROF.	DR.	W.Z.	JOHANNES	GENERAL	HOSPITAL	KUPANG
Authors: Fouk Maria Fatimah , Wihastuti Titin Andri , Ningsih Dewi Kartikawati 
Published: January 2019

Overcrowding patients is a crisisÂ problem in hospital and plays a significant role as a front line in hospital which performing good and bad quality of care. Length of Stay (LOS) patients admission measurement indicator toward service process and patients density marker. Length of stay has important essence in reviewing process because helping to identify the cause of action delay and elongated LOS. EDLOS is influenced by input and trough put factor. Input factor: age, coming time, main complaint and co-morbidity. Trough put factor: triage level, door to doctor, the quickness in laboratory check, the quickness in specialist consultation and patients transfer to nursing room, staffing. This study is aimed to analyze the correlation of causing factor on action delay with LOS patients admissionÂ in Prof. Dr. W. Z. Johannes Public Hospital Kupang. This study uses cross sectional approach and quota sampling by the number of 200 patients and nurses also doctors. Data was collected by observation sheet. Result of this study shows that there are significant correlation between co-morbidity with LOS patients admission (p value = 0,001 and r = - 0,227), between the quickness of specialist consultation with LOS patients admission (p value = 0,001 and r = 0,238) and between patients transfer to nursing room LOS patients admission (p value = 0,000 and r = 0,699). Based on the result of linear regression test, it is concluded that factor that has very close correlation with LOS patients admission patients transfer to nursing room (p value < 0,001, regression coefficient 0,015 and correlation coefficient 0,774). Conclusion: co-morbidity, specialist consultation and patients transfer to nursing room is LOS patients admission predictor. Developing centralized bed control dan transporter is mandatory for decrease overcrowding and LOS patients admission in emergency department.
Hellenistic Rural Settlement and the City of Thurii. The survey evidence (Sibaritide, southern Italy)
Authors: Oome N. , Attema P.A.J. 
Published: January 2019

This paper examines the nature and chronology of Hellenistic rural settlement in the foothills of the Sibaritide in northern Calabria (southern Italy) on the basis of selected archaeological sites of this period recorded in field surveys by the Groningen Institute of Archaeology (GIA) between 1995 and 2008. The collected material of this subset is suitable for answering questions about the chronology and nature of Hellenistic rural settlement in the foothills, and about how the identified pattern relates to the founding and development of the Hellenistic city of Thurii in the plain of Sybaris in the mid 5th c. BC. After an overview of previous field research, the authors discuss the archaeological evidence in detail and evaluate it in the context of current knowledge regarding Hellenistic settlement patterns in the Sibaritide, and in southern Italian landscapes more generally. The paper concludes by placing the data in the socio-economic and geopolitical context in which the Greek city state of Thurii functioned.