bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the influence of advanced maternal age on adverse perinatal outcome in Southern Anhui province, China
Authors: Ge Dandan , Si Mingshu , Xia Yong 
Published: September 2019

Abstract
Background : Elderly parturient women may face many pregnancy risks, which have serious consequences for perinatal and maternal. The objective of this study is to explore the association between advanced maternal age and adverse perinatal outcomes. Methods : In this study, we used retrospective study to randomly selected 977 puerpera ( aged 35 years and older) as the research group and 977 puerpera (aged 20 to 34 years older) as the control group from Yijishan Hospital for the years 2017-2018. Univariate analysis was used to test the association between gestational age and adverse perinatal outcomes. Multiple logistic regression analysis was performed to examine the factors associated with adverse perinatal outcome. A nomogram was conducted to explore the risk probability between risk factors and adverse perinatal outcome. Results : the AMA group (23.2%)exhibited a higher incidence of adverse perinatal outcome than the Non-AMA group(17.8%). Multiple logistic regression analysis showed among those who experienced multiple pregnancy, premature, hypertension, diabetes were more likely to induce adverse perinatal outcome. In this study, the risk of adverse perinatal outcome occurred in women aged 35 to 45 years with multiple pregnancy and preterm birth all was 42%-48%. The risk of adverse perinatal outcome in women aged 35 to 45 years with other variables respectively were 18%-19% (diabetes), 16%-18% (hypertension).The risk of adverse perinatal outcomes among women with AMA combined with these variables were higher than the counterpart. Conclusions : AMA is the risk factor for adverse perinatal outcome among pregnancy women and the probability that these risk factors combined with age produced poor perinatal outcome were also found. Active intervention measures focusing on the complications and treatment in AMA should be taken to ensure the health of mother and baby.
A portable breast cancer detection system based on smartphone with infrared camera
Authors: Ma Jian , Shang Pengchao , Lu Chen , Meraghni Safa , Benaggoune Khaled , Zuluaga Juan , Zerhouni Noureddine , Devalland Christine , Al Masry Zeina 
Published: September 2019

The traditional detection methods have the disadvantages of radiation exposure, high cost, and shortage of medical resources, which restrict the popularity of early screening for breast cancer. An inexpensive, accessible, and friendly way to detect is urgently needed. Infrared thermography, an emerging means to breast cancer detection, is extremely sensitive to tissue abnormalities caused by inflammation and vascular proliferation. In this work, combined with the temperature and texture features, we designed a breast cancer detection system based on smart phone with infrared camera, achieving the accuracy of 99.21 % with the k-Nearest Neighbor classifier. We compared the diagnostic results of the low resolution, originated from the phone camera, with the high resolution of the conventional infrared camera. It was found that the accuracy and sensitivity decreased slightly, but both of them were over than 98 %. The proposed breast cancer detection system not only has excellent performance but also dramatically saves the detection cost, and its prospect will be fascinating.
Market Research of Bottled Drinking Water
Authors: Павлов Игорь , Pavlov Igor , Ревякина Елизавета , Revyakina Elizaveta , Елесина Виктория , Elesina Victoria 
Published: September 2019

Drinking water holds a valuable place in human ration. When choosing a water brand, the consumer is guided by a number of factors. Customers place various demands on a product. Thus, during the market launch the manufacturer needs to
know the consumer’s attitude to a given product. The determinant factors for product purchase include consumer’s knowledge of product trade names, information awareness, recognition of the product among other manufacturers, and advertising response. The marketing research was conducted in the city of Biysk (Altai Krai, Russia) and pursued the following goals: to determine public attitudes to bottled drinking water; to assess the factors that influence buying decisions; to evaluate the perspective presence of Altai Krai’s manufacturers at the bottled water market. The research was done through questionnaire survey and provided fairly complete information on consumers’ opinions, choices, and behavior. This survey covered different consumer categories, a total of 300 respondents of different age groups, income level, and social class. The survey results demonstrated that 56.6% of the respondents still use tap water. However, only 15.8% actually give their precedence to tap water value account; the remaining 84.2% can therefore be viewed as potential customers. The survey revealed that the major consumer’s criterion for water is the product price (42.8%). The second criterion in order of importance is the water quality, which constituted 16.7% of the total number of respondents. The paper contains data on consumers’ preferences by water manufacturers. The consumers were found to use water of manufacturers from other regions (51.6%). Only 42.4% gave their preference to local manufacturers, though Altai Krai is famous for its environmentally-clean drinking water sources. Price choices for drinking water were ascertained, and 53.6% of the respondents were found to be ready to pay 40 to 60 rubles per liter, which corresponds with the local manufacturers’ pricing policy. When asked if the quality of local water brands is trustworthy, the great majority of the consumers (86.4%) gave credit to the local manufacturers’ water quality. Based on the data on favourite brands, the most popular brands turned out to be the most promoted ones. The local manufacturers’ efforts in this direction require available persuasion means, such as ad placement in mass media and promotional events at sales places.
Entre a “Grande Mãe” e a “Musa”, a “Louca”: embate de gênero e estereótipos na campanha publicitária “snickers, você não é você quando está com fome”
Authors: Coelho Barros Dulce Elena , Pedroso Almeida Lorena Martins , Carrenho Cocato Sarah Mariana Longo 
Published: September 2019

Este artigo traz à memória dois dos mais expressivos estereótipos que acompanham a trajetória feminina junto à estrutura social, quais sejam, o da “grande mãe” e o da “musa”. O empreendimento histórico-discursivo será, aqui, rememorado a partir da campanha publicitária da barra de chocolate Snickers, que tem como slogan “Você não é você quando está com fome”. O enfoque se volta, mais vivamente, para duas das peças publicitárias videográficas, produzidas especificamente para serem veiculadas no Brasil, que se realizam com base numa perspectiva de embate de gênero masculino versus feminino. O anúncio publicitário “República” (2013) apresenta como protagonista a atriz Betty Faria e o anúncio publicitário “Vestiário” (2015) conta com a participação da atriz, não menos consagrada, Claudia Raia. Com base nessas duas materialidades eleitas enquanto corpus analítico, buscamos, em consonância com os pressupostos da Análise Crítica do Discurso (ACD) de Norman Fairclough, desvelar significados relativos ao cenário no qual entre a figura da “mãe” e da “musa” se interpõe a figura da “louca” que, aparentemente salvaguardada no simulacro da representação teatral, perpetua representações sociodiscursivas associadas ao pensamento patriarcal que identifica a mulher como naturalmente irritadiça, instável e psicologicamente patologizada.
PALAVRAS CHAVE: Análise Crítica do Discurso; Estereótipos de gênero; Identidade feminina.
Perspectivas metacognitivas e metalinguísticas para o ensino de leitura e escrita em língua materna
Authors: Botelho Patricia Ferreira , Neves Fabiana Esteves 
Published: September 2019

Com o propósito de contribuir no debate sobre o ensino de leitura e escrita em língua materna no Brasil, reunimos alguns estudos, de base cognitivo-ecológica e metacognitiva, em forma de uma proposta geral de abordagem desses conteúdos, vistos aqui como habilidades processuais. Neste sentido, nosso trabalho visa refletir sobre as dificuldades e as habilidades de leitura e escrita dos alunos para, então, propor alternativas de desenvolvimento dessas atividades para professores e estudantes. Primeiramente, apresentamos alguns pressupostos em cognição, metacognição e gerenciamento metalinguístico que fundamentam a abordagem da leitura e da escrita. Em seguida, problematizamos as concepções sobre ler e escrever ainda vigentes na escola e oferecemos alternativas que consideram leitura e escrita como processos. Por fim, destacamos como componentes centrais da proposta as estratégias metacognitivas e metalinguísticas, caminho de orientação sobre as formas como as pessoas podem pensar acerca das atividades que realizam. Em termos do ensino de leitura e de escrita, essas estratégias relacionam-se à importância de pôr em perspectiva a necessidade de negociação de informações focada no aprendizado.
miR-146a-5p Regulated Cell Proliferation and Apoptosis by Targeting SMAD3 and SMAD4
Authors: Qiu Meiyu , Li Tao , Wang Binhu , Gong Hongbin , Huang Tao 
Published: September 2019

Background:
microRNAs (miRNAs) are a small, endogenous non-coding RNAs that are
involved in post-transcriptional gene regulation of many biological processes, including embryo
implantation and placental development. In our previous study, miR-146a-5p was found expressed
higher in the serum exosomes of pregnant sows than non-pregnant. The research on miR-146a-5p
has been mainly related to human diseases, but there are few studies on its effects on the
reproduction of sows in early pregnancy.

Objective:
In this article, our motivation is to study the role of miR-146a-5p in the early pregnancy
of sows on the cell proliferetion and apoptosis by targeting SMAD3 and SMAD4.

Methods:
Bioinformatics software was used to identify the target genes of miR-146a-5p. The wildtype
and mutant-type recombinant plasmids of dual-luciferase reporter with 3'-UTR of Smad3 or 3'-
UTR of Smad4 were constructed, and co-transfected in porcine kidney cell (PK-15 cell) with miR-
146a-5p mimic, mimic-NC(M-NC), inhibitor and inhibitor-NC(IN-NC), then dual-luciferase
activity analysis, qRT-PCR and Western blot were performed to verify the target genes. After the
transfection of BeWo choriocarcinoma cell (BeWo cell) with miR-146a-5p mimic, M-NC, inhibitor
and IN-NC, the mRNA expression of Caspase-3, BAX and Bcl-2 was measured using qRT-PCR,
and the cell proliferation was measured using CCK-8 kit.

Results:
The luciferase, mRNA and protein expression of Smad3 in PK-15 cells treated by Smad3-
3'-UTR-W co-transfected with miR-146a-5p mimic were significantly lower than that with miR-
146a-5p M-NC, and the results of Smad4 were similar to Smad3, but the protein expression had a
trend to lower in mimic group. The expression level of Bcl-2 in the miR-146a-5p mimic group was
significantly lower than that in the miR-146a-5p M-NC group, but the expression pattern of
Caspase-3 was just opposite. The mimic of miR-146a-5p reduced the proliferation of BeWo cells,
however the inhibitor increased.

Conclusion:
Smad3 and Smad4 are the direct target genes of miR-146a-5p. The expression of
Smad3 and Smad4 were affected by the mimic and inhibitor of miR-146a-5p. miR-146a-5p affects
cell apoptosis and proliferation by regulating their target genes. This study provided new data to
understand the regulation mechanism of early pregnancy in sows.
Next-Generation Sequencing: An Emerging Tool for Drug Designing
Authors: Tripathi Pooja , Singh Jyotsna , Lal Jonathan A. , Tripathi Vijay 
Published: September 2019

Background:
With the outbreak of high throughput next-generation sequencing (NGS), the biological
research of drug discovery has been directed towards the oncology and infectious disease therapeutic areas, with
extensive use in biopharmaceutical development and vaccine production.

Method:
In this review, an effort was made to address the basic background of NGS technologies, potential applications
of NGS in drug designing. Our purpose is also to provide a brief introduction of various Nextgeneration
sequencing techniques.

Discussions:
The high-throughput methods execute Large-scale Unbiased Sequencing (LUS) which comprises of
Massively Parallel Sequencing (MPS) or NGS technologies. The Next geneinvolved necessarily executes Largescale
Unbiased Sequencing (LUS) which comprises of MPS or NGS technologies. These are related terms that
describe a DNA sequencing technology which has revolutionized genomic research. Using NGS, an entire human
genome can be sequenced within a single day.

Conclusion:
Analysis of NGS data unravels important clues in the quest for the treatment of various lifethreatening
diseases and other related scientific problems related to human welfare.
Recent Advances and Computational Approaches in Peptide Drug Discovery
Authors: Maurya Neha S. , Kushwaha Sandeep , Mani Ashutosh 
Published: September 2019

Background:Drug design and development is a vast field that requires huge investment along with a long duration for providing approval to suitable drug candidates. With the advancement in the field of genomics, the information about druggable targets is being updated at a fast rate which is helpful in finding a cure for various diseases.Methods:There are certain biochemicals as well as physiological advantages of using peptide-based therapeutics. Additionally, the limitations of peptide-based drugs can be overcome by modulating the properties of peptide molecules through various biomolecular engineering techniques. Recent advances in computational approaches have been helpful in studying the effect of peptide drugs on the biomolecular targets. Receptor – ligand-based molecular docking studies have made it easy to screen compatible inhibitors against a target.Furthermore, there are simulation tools available to evaluate stability of complexes at the molecular level. Machine learning methods have added a new edge by enabling accurate prediction of therapeutic peptides.Results:Peptide-based drugs are expected to take over many popular drugs in the near future due to their biosafety, lower off-target binding chances and multifunctional properties.Conclusion:This article summarises the latest developments in the field of peptide-based therapeutics related to their usage, tools, and databases.
Development of Secondary Osteoporosis in Teenage Girls with Menstrual Disorders
Authors: Popova-Petrosyan Elena V. , Kulanthaivel Shanmugaraj , Balasundaram Keerthanaa 
Published: September 2019

Introduction:
Nowadays, the most common problem in teenage girls is them facing
menstrual disorders that develop secondary osteoporosis in their adolescent period. The locomotor
system disorder is noticed more often in girls with adolescence hormone pathology, than in the
population. This has an enormous human and socio-economic impact. Osteoporosis is estimated to
affect 200 million women worldwide.

Objective:
The aim of this research is to determine the development of secondary osteoporosis in
girls during their adolescent period.

Materials and Methods:
An analysis of 173 girls aged from 13 to 17 were under our supervision in
the children’s clinic sanatorium “Zdravnisa”. Girls were divided into four groups according to their
menstrual disorders.

Results:
As per the correlation analysis data, the influence of steroid hormones level on bone content
has a cumulative effect on girls.

Conclusion:
For patients with oligomenorrhea, secondary amenorrhea, and polymenorrhea, there
were disordered correlations of gonadotropic hormones. Correlations between calcium, phosphorus,
and magnesium are disordered, which can be proof of mineralization processes disorder. As per the
correlation analysis data for the girls with adolescence pathology, there were revealed direct average
correlation connections between the concentration of steroid hormones and structural-functional
properties of bony tissue. Low concentration of progesterone in the blood of girls with adolescence
pathology is one of the main reasons for bone content deficit, development of osteoporosis, and
scoliosis progression.
Recent Patents on the Triboelectrostatic Separation of Fly Ash
Authors: Haisheng Li , Wenping Wang , Yinghua Chen , Xinxi Zhang , Chaoyong Li 
Published: September 2019

Background:
The fly ash produced by coal-fired power plants is an industrial waste. The
environmental pollution problems caused by fly ash have been widely of public environmental concern.
As a waste of recoverable resources, it can be used in the field of building materials, agricultural
fertilizers, environmental materials, new materials, etc. Unburned carbon content in fly ash has
an influence on the performance of resource reuse products. Therefore, it is the key to remove unburned
carbon from fly ash. As a physical method, triboelectrostatic separation technology has been
widely used because of obvious advantages, such as high-efficiency, simple process, high reliability,
without water resources consumption and secondary pollution.

Objective:
The related patents of fly ash triboelectrostatic separation had been reviewed. The structural
characteristics and working principle of these patents are analyzed in detail. The results can
provide some meaningful references for the improvement of separation efficiency and optimal design.

Methods:
Based on the comparative analysis for the latest patents related to fly ash triboelectrostatic
separation, the future development is presented.

Results:
The patents focused on the charging efficiency and separation efficiency. Studies show that
remarkable improvements have been achieved for the fly ash triboelectrostatic separation. Some
patents have been used in industrial production.

Conclusion:
According to the current technology status, the researches related to process optimization
and anti-interference ability will be beneficial to overcome the influence of operating conditions
and complex environment, and meet system security requirements. The intelligent control can not
only ensure the process continuity and stability, but also realize the efficient operation and management
automatically. Meanwhile, the researchers should pay more attention to the resource utilization
of fly ash processed by triboelectrostatic separation.
Structural Behavior of Geopolymer Concrete Thin Wall Panels Based on Metakaolin and Recycled Concrete Aggregate
Authors: Alsaraj Wissam Kadhim , Fadhi Shaimaa Hasan , Alserai Sahar Jabbar 
Published: September 2019

Introduction:
Due to the current popularity of Reinforced Concrete (RC) wall construction and the new published codes for concrete, RC walls have become just as important structural elements as beams, slabs and columns.

Methods:
This paper presents the structural behavior of geopolymer concrete thin wall panels based on metakaolin and recycled concrete aggregate subjected to axial eccentric uniformly distributed loading with varying Aspect Ratios (AR=H/L) and steel reinforcement ratios. The experimental program includes testing of five two-way thin geopolymer concrete wall panels; fixed at all sides and applying the load axially with eccentricity equal to the wall thickness/6.

Results and Conclusion:
The results indicate that the load-carrying capacity of the geopolymer concrete wall panels increased to about 63% with a decrease in AR (H/L) from 1.875 to 0.75. The lateral deflection decreased to about 50% with a decrease in AR (H/L) from 1.875 to 0.75. Also, the results show that the load-carrying capacity of the geopolymer concrete wall panels increased to nearly 48% with an increase in the steel reinforcement ratio from 2.32% to 3.38%. The lateral deflection also decreased by 20% with an increase in the steel reinforcement ratio to 3.38%. The results show that locally manufactured Metakaolin can be used for producing Geopolymer concrete.
Stroke Severity and Outcomes in Patients with and without Atrial Fibrillation
Authors: Ragelytė Augustė , Rudokaitė Gabrielė , Žaliaduonytė-Pekšienė Diana , Zabiela Vytautas 
Published: September 2019

Background
Atrial fibrillation (AF) is a major risk factor for ischemic stroke. It is important to verify the effect of AF on the outcomes of stroke.

Objective
To compare stroke severity and outcomes regarding stroke victims with and without AF.

Methods
Analysis of the medical data (including age, sex, stroke type, localization, treatment method, severity and outcomes of the stroke (according to the National Institutes of Health Stroke Scale (NIHSS) score, Barthel index score, death), antithrombotic treatment) of 200 stroke patients (100 with AF, 100 without AF).

Results
Patients with AF were older than non-AF patients (76.19 ± 9.4 vs. 66.99 ± 11.7, p<0.001), there were more women among them (63 vs. 39, p=0.01). 53 patients with AF had used anticoagulants (AC) before stroke (most of them were used ineffectively), 99 had had indications to use them. The distribution of the type of the stroke did not differ significantly between groups. AF patients had stroke in the area of the brain supplied by the carotid artery more often (95% vs. 78%, p<0.001). Initial stroke severity (p=0.006), NIHSS after thrombolysis (p=0.008), NIHSS 7 days after thrombolysis (p=0.01) was higher in AF patients; Barthel index score (p=0.194) and mortality (p=0.323) did not differ.

Conclusion
Patients with AF experienced more severe strokes and presented higher neurologic deficits than patients without this condition. Nevertheless, the mortality and patients' final functional status did not differ. AC usage in patients with AF did not alleviate neurologic deficits and stroke outcomes possibly due to their insufficient usage.
Improving Team-Based Decision Making Using Data Analytics and Informatics: Protocol for a Collaborative Decision Support Design
Authors: Roosan Don , Law Anandi V , Karim Mazharul , Roosan Moom 
Published: September 2019

BackgroundAccording to the September 2015 Institute of Medicine report, Improving Diagnosis in Health Care, each of us is likely to experience one diagnostic error in our lifetime, often with devastating consequences. Traditionally, diagnostic decision making has been the sole responsibility of an individual clinician. However, diagnosis involves an interaction among interprofessional team members with different training, skills, cultures, knowledge, and backgrounds. Moreover, diagnostic error is prevalent in the interruption-prone environment, such as the emergency department, where the loss of information may hinder a correct diagnosis.ObjectiveThe overall purpose of this protocol is to improve team-based diagnostic decision making by focusing on data analytics and informatics tools that improve collective information management.MethodsTo achieve this goal, we will identify the factors contributing to failures in team-based diagnostic decision making (aim 1), understand the barriers of using current health information technology tools for team collaboration (aim 2), and develop and evaluate a collaborative decision-making prototype that can improve team-based diagnostic decision making (aim 3).ResultsBetween 2019 to 2020, we are collecting data for this study. The results are anticipated to be published between 2020 and 2021.ConclusionsThe results from this study can shed light on improving diagnostic decision making by incorporating diagnostics rationale from team members. We believe a positive direction to move forward in solving diagnostic errors is by incorporating all team members, and using informatics.International Registered Report Identifier (IRRID)DERR1-10.2196/16047