bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐Related Quality of Life and Experiences of Minor Children With Parental Cancer—A Family‐Based Multilevel Analysis of Determinants
Authors: Heuser Christian , Ernstmann Nicole , Heier Lina , Nakata Hannah , Geiser Franziska , Karger André , Icks Andrea , Brüne Manuela , Haastert Burkhard , Horbach‐Bremen Rebecca , Brümmendorf Tim , Petermann‐Meyer Andrea 
Published: November 2024

ABSTRACTObjectiveChildren in families with parental cancer may experience emotional, social or physical problems. The aims are to analyze child, parent and family‐based determinants of children's health‐related quality of life (HRQoL) and their experiences of parental cancer.MethodsAs part of a mixed‐methods, multicenter, prospective, interventional non‐randomized study “Family‐SCOUT,” a family‐centered intervention in the form of care and case management was developed. Children's HRQoL (KIDSCREEN‐10) was assessed at baseline (study inclusion). Descriptive analyses and family cluster‐adjusted linear mixed models were performed. Qualitative coding of children's experiences reported in an open‐ended text field of the questionnaire was performed.ResultsFour hundred and seventy‐two families with 472 parents with cancer and 649 children were included in the study of which N = 346 were analyzed. The average age of the children was 12.8 years. 48% of the children were female. Family cluster‐adjusted mixed linear model showed significant associations between children's HRQoL (dependent variable) and children's age (−0.44, p = 0.023, 95%‐CI = −0.82 to −0.06) and between families (ICCnull model = 0.377, Pseudo‐R2 = 0.443). Children experienced changes in the family situation, such as daily routines and communication among all family members, death of a parent, COVID‐19‐related difficulties, and supportive social relationships.ConclusionsChild, parent and family‐based factors appear to be related to children's HRQoL. Research on children's HRQoL and experiences in the context of parental cancer underscores the need for a multidimensional and family‐based approach to support these children.
Psychological Risk Factors on Hematopoietic Stem Cell Transplantation Patients: Insights From National Readmission Database Analysis
Authors: Zhang Qi , Yu Qiuyan , Chen Qian , Dong Hongjing , Fang Min , Liu Na , Li Wen , Wang Hui , Zhao Nan , Zhu Xunxun , Zhang Kui , Zhou Chi 
Published: November 2024

ABSTRACTBackgroundPsychosocial risk factors (PSRFs) have emerged as important nontraditional risk factors for poor medical outcomes but have not been well‐studied in the field of hematopoietic stem cell transplantation (HSCT).ObjectivesIn this study, we retrospectively examined in‐hospital and short‐term outcomes in patients with PSRFs who underwent HSCT.MethodsWe used the National Readmission Database (NRD) to identify patients who underwent HSCT between 2011 and 2020. Patients were stratified based on the presence of either 0 or ≥ 1 PSRFs, which included factors such as mental illness, substance abuse, cognitive problems, a low income level, and an uninsured status. Patients were also classified into allogeneic‐HSCT (allo‐HSCT) and autologous‐HSCT (auto‐HSCT) groups. Our primary endpoints were in‐hospital and short‐term outcomes.ResultsIn this nationally representative cohort, 90,747 patients underwent auto‐HSCT, while 26,600 patients underwent allo‐HSCT. In the auto‐HSCT group, individuals with PSRFs exhibited notably higher in‐hospital mortality (2.4% vs. 2.8%; p < 0.001) and 30‐day all‐cause readmission rates (14.4% vs. 17.8%; p < 0.001) compared to those without PSRFs. Similarly, within the allo‐HSCT group, patients with PSRFs had significantly higher in‐hospital mortality (5.4% vs. 6.4%; p < 0.001) and 30‐day all‐cause readmission rates (27.3% vs. 31.2%; p < 0.001) compared to those without PSRFs. After adjusting for risk factors, the presence of PSRFs emerged as a substantial predictor for heightened 30‐day readmission in allo‐HSCT and auto‐HSCT.ConclusionThe presence of PSRFs is correlated with poorer in‐hospital and short‐term outcomes after both allo‐HSCT and auto‐HSCT, with a more pronounced effect observed in allo‐HSCT. This research underscores the significance of pinpointing high‐risk patients and implies support for merging PSRFs after HSCT is beneficial.
Membrane tension‐dependent conformational change of Isoleucine 106 of loop B diminishes water permeability in FaPIP2;1
Authors: Caviglia Agustín , Espinoza‐Muñoz Nicolás , Alvear‐Arias Juan José , Galizia Luciano , Guastaferri Florencia , Zimmermann Rosario , Sigaut Lorena , Amodeo Gabriela , González Carlos , Ozu Marcelo , Garate José Antonio 
Published: November 2024

AbstractAquaporins (AQPs) are membrane proteins specialized in facilitating water transport across membranes. Mechanical stress is one of the various stimuli that regulate AQPs. Briefly, there are several studies that report a decrease in permeability upon an increase in membrane tension. However, the molecular details of this mechanosensitive (MS) response are still a matter of debate. Our work attempts to close that gap in knowledge by providing evidence of a conformational change that occurs inside the pore of the strawberry aquaporin FaPIP2;1. Via osmotic shock experiments and molecular dynamics (MD) simulations, we found that a residue of loop B, I106, is key to the blocking of the permeation pathway and such a change is almost exclusively found under membrane tensile stress. In detail, osmotic shock experiments exhibited a nonlinear increment in water fluxes for increasing osmolarities, evidencing a decrease in the FaPIP2;1 permeability. MD simulations under membrane tension showed the same trend, with a significant increase in states with a low water permeability. The latter was correlated with a conformational change in I106 that generates a permeation barrier of around 18 kJ mol−1, effectively closing the pore. This work constitutes the first report of a PIP type aquaporin reacting to tensile stress in the membrane. Our findings could pave the way to test whether this conformational change is also responsible for mechanical gating in the other MS aquaporins, both those already reported and those still waiting to be found.
Kunitz‐type trypsin inhibitor from durian (Durio zibethinus) employs a distinct loop for trypsin inhibition
Authors: Deetanya Peerapon , Limsardsanakij Kakanang , Sabat Grzegorz , Pattaradilokrat Sittiporn , Chaisuekul Chatchawan , Wangkanont Kittikhun 
Published: November 2024

AbstractKunitz‐type trypsin inhibitors are ubiquitous in plants. They have been proposed to be a part of a defense mechanism against herbivores. Trypsin inhibitors also have potential applications in the biotechnology industry, such as in mammalian cell culture. We discovered that durian (Durio zibethinus) seed contains Kunitz‐type trypsin inhibitors as identified by N‐terminal sequencing and mass spectrometry. Eleven new trypsin inhibitors were cloned. The D. zibethinus trypsin inhibitors (DzTIs) that are likely expressed in the seed were produced as recombinant proteins and tested for trypsin inhibitory activity. Their inhibitory activity and crystal structures are similar to the soybean trypsin inhibitor. Surprisingly, a crystal structure of the complex between DzTI‐4, the DzTI with the lowest inhibitory constant, and bovine trypsin revealed that DzTI‐4 utilized a novel tryptophan‐containing β1‐β2 loop to bind trypsin. Site‐direct mutagenesis confirmed the inhibitory role of this loop. DzTI‐4 was not toxic to the HEK293 cells and could be used in place of the soybean trypsin inhibitor for culturing the cells under serum‐free conditions. DzTI‐4 was not toxic to mealworms. However, a mixture of DzTIs extracted from durian seed prevented weight gain in mealworms, suggesting that multiple trypsin inhibitors are required to achieve the antinutritional effect. This study highlights the biochemical diversity of the inhibitory mechanism of Kunitz‐type trypsin inhibitors and provides clues for further application of these inhibitors.
Villagers' Resistance to Gentrification‐Led Displacement in the Guanxi Society: Lessons From Rural Guangzhou, China
Authors: Huang Shizhen , Liu Yuting , Chen Qingyi , Zhang Yuanlin 
Published: November 2024

ABSTRACTThe antigentrification campaign has gained global attention because it is crucial for realising social justice, particularly against displacement. Numerous literature has focused on government management, however, there is a dearth of research on the resistance undertaken by the potential displacees. Therefore, this paper explores villagers' survivability when facing displacement threats within China's guanxi society. The guanxi provides a fresh lens on Chinese social development, distiling intergroup relationships into four states that reveal power dynamics within gentrification and enable a nuanced analysis of displacement and resistance. The case of Xiaozhou Village is examined, tracing villagers' living dynamics over the past three decades. The study reveals that villagers have effectively resisted sociocultural displacement pressure and exclusionary displacement by maintaining or preserving their fields. Guanxi provides a perspective for examining how villagers legally possess capital, engage in habitus‐driven competition against gentrifiers, and ultimately support their community cohesion. This paper contributes to a deeper understanding of the uneven micro‐geopolitics of gentrification and offers insights into the effective mitigation of displacement.
A Control Chart for the Joint Monitoring of Mean and Variance With Klein's Supplementary Rule
Authors: Quinino Víctor Brito , Costa Marcelo Azevedo , Trindade Anderson Laécio Galindo 
Published: November 2024

ABSTRACTSupplementary run rules have been employed since the 1950s to enhance the performance of control charts, such as the control chart, which aims to control the process mean, or control chart, which aims to control the process variance. One simple, effective, and popular suggestion is Klein's 2‐of‐2, which signals an out‐of‐control process only when two sequential sample averages are observed above the upper control limit or below the lower control limit. We propose to implement Klein's 2‐of‐2 for a more complex control chart, the joint control chart, which aims to simultaneously monitor the mean and the variance of a process. Compared with the traditional control chart, using this rule for the control chart reduces the average run length (ARL) and standard deviation of the run length (SDRL) for detecting small process shifts while maintaining high applicability owing to the ease of use in employing the 2‐of‐2 rule in practical environments. Klein's run rule was implemented in the control chart through a 15‐state Markov chain, and its performance was compared with the basic control chart as well as the exponentially weighted moving average (EWMA) chart, known to have excellent capabilities in detecting small process average shifts at the cost of a more complex control scheme. The newly proposed Klein control chart demonstrated superior performance compared to the traditional control chart and competitive performance even against the more complex joint EWMA control chart.
Ultralarge Hyperpolarizability, Novel Ladder‐Type Heteroarenes Electro‐Optic Chromophores: Influence of Fused Heterocyclic π‐System and Push–Pull Effect on Nonlinear Optical Properties
Authors: Sun Hejing 
Published: November 2024

ABSTRACTA new series of ladder‐type heteroarenes electro‐optic (EO) chromophores based on unique fused oligothiophene, oligofuran, and oligopyrrole bridge with a strong push–pull effect were designed, and their distinctive electric structure and nonlinear optical (NLO) properties were investigated by multiple methods, including DOS analysis, CPKS method, SOS model, TSM model, and hyperpolarizability density analysis. Interestingly, it is found that the introduction of different strengths of donor and acceptor moieties, the nature of ladder‐type heteroarenes bridge, and the medium polarity play critical roles in achieving ultra‐large hyperpolarizabilities. Encouragingly, the DN1‐6Fu‐AS1 and DN1‐6Py‐AS1 both exhibit ultra‐large βprj values (up to 12965.5 × 10−30 esu) and βtot value (up to 13238.2 × 10−30 esu), owing to their exceptionally low transitions energy and large variation of dipole moment. The DO2‐6Fu‐AO2, DO2‐6Th‐AO2, DO2‐6Fu‐AS1, and DO2‐6Th‐AS1, exhibit very deep HOMO levels, which are expected to have superior air stability and effectively prevent large leakage currents. Hirshfeld surface analysis and interaction region indicator analysis were employed to explore the noncovalent interactions in the dimer. The DO2‐6Fu‐AS1 and DO2‐6Py‐AS1 show the outstanding electro‐optical Pockels effect, and DN1‐6Fu‐AO2 exhibit large SHG responses. These unique and brand‐new push‐pull ladder‐type heteroarenes chromophores are promising candidates for chip‐scale EO modulators, and electronic and photonic devices in emerging communication, energy, analog, and digital technologies.
Identification of the chemical constituents in the leaves and twigs of Nerium oleander by ultrahigh‐performance liquid chromatography coupled to quadrupole Orbitrap high‐resolution mass spectrometry
Authors: Ling Yun , Yu Jingmou , Huang Yi , Chen Mengmo , Zhang Qing 
Published: November 2024

RationaleNerium oleander L. (Apocynaceae) is a medium‐sized evergreen flowering tree and is distributed widely in China. Various parts of N. oleander have been used medicinally and are reported to possess a wide range of biological activities, including cardiotonic, cytotoxic, and central nervous system depressant activities. However, there is a lack of in‐depth understanding of the chemical constituents in various parts of N. oleander.MethodsAn ultrahigh‐performance liquid chromatography coupled to quadrupole Orbitrap high‐resolution mass spectrometry (UHPLC‐Q‐Orbitrap HRMS) method was developed for the qualitative analysis of the chemical constituents in the leaves and twigs of N. oleander.ResultsAs a result, 50 compounds, including phenolic derivatives, flavonoids, cardenolides, and triterpenoids, were identified in N. oleander. Among them, 50 compounds were identified in the leaves of N. oleander, whereas 25 compounds were identified in the twigs of N. oleander. It is noteworthy that 16 phenolic derivatives and 4 flavonoids were first detected in this plant and 10 cardenolides were deduced as potential new compounds.ConclusionsThis study provided an effective method for comprehensively analyzing the complex system of medicinal plants and enriched the chemical compositions in N. oleander.
Lead‐Free All Inorganic Rubidium Copper Halide Rb2CuX3 (X = Cl, Br) for UVC Photodetector with Fast Response
Authors: Kumar Ankit , Kumar Praveen , Saini Ankush , Bag Monojit , Kar Prasenjit 
Published: November 2024

AbstractRecently, lead halide perovskites have shown great potential in the photodetection field. Unfortunately, the existence of toxic lead elements restricts their practical application. Herein, high‐quality 1D lead‐free crystals Rb2CuX3 (X = Cl, Br) are successfully synthesized in an acidic medium. Rb2CuCl3 and Rb2CuBr3 display violet photoluminescence emission peaks at 401 and 388 nm with a high exciton lifetime of 12.78 and 59.67 µs, respectively, which is due to self‐trapped excitons (STE). Furthermore, a photodetector is fabricated to detect harmful UVC radiation with Rb2CuBr3 as a light absorber. The proposed photodetector has a responsivity of 0.92 mA W−1 and a specific detectivity of 1.57 × 109 Jones with a fast response speed of 2.67/2.70 µs for rise/fall time, respectively. In addition, both the samples show good stability against open air, and continuous ultraviolet light (254 nm), as well as good thermal stability which is necessary for device fabrication. Thus, the present study suggests that stable, non‐toxic, and environment‐friendly Rb2CuX3 (X = Cl, Br) can be a promising candidate for future UVC optoelectronic devices.
Mechanistic Insights into Gas Adsorption on 2D Materials
Authors: Joshi Manisha , Ren Xiaojun , Lin Tongxi , Joshi Rakesh 
Published: November 2024

AbstractOwing to their exceptional characteristics, such as one‐atom thickness, high specific surface area, and tunability of surfaces, 2D materials are excellent templates to study the surface‐dependent gas adsorption phenomenon. Moreover, the properties of 2D materials like morphology, bandgap, structure, and carrier mobility can be modulated easily by modification methods such as functionalization, defect and doping engineering. These modifications create and activate unconventional inert and active sites, leading to the selective adsorption of gases via mechanisms such as charge transfer kinetics, Schottky‐barrier modification, and surface interactions. These methods enhance the adsorption sites by adding covalent and non‐covalent moieties to the 2D surface and play a critical role in developing ultrafast gas sensing with high sensitivity, selectivity, fast response/recovery rates, and low detection limits. Here, this perspective is presented on the mechanism of the adsorption process of gases on modified 2D surfaces based on recent studies related to adsorption‐dependent applications of 2D materials.
A Novel kgd‐Topological Covalent Organic Framework with Optimum Pore Size for Efficient Benzene/Cyclohexane Separation
Authors: Cai Borui , Wu Wenhao , Miao Xiaozeng , Yang Xi , Duan Limin , Lin Daohui , Yang Kun 
Published: November 2024

AbstractSeparation of benzene and cyclohexane is essential for obtaining high‐purity cyclohexane in the chemical industry and for resource recovery from exhaust gas, but is one of the most challenging separation processes due to their highly similar boiling points and kinetic diameters. Herein, based on the isoreticular contraction strategy, a novel covalent organic framework (i.e., HFPB‐TAB‐COF) with kgd topological structure and average pore size of 5.70 Å, between the kinetic diameters of benzene (5.60 Å) and cyclohexane (6.10 Å), is synthesized for benzene/cyclohexane separation by pore confinement effect. HFPB‐TAB‐COF has the highest ideal adsorbed solution theory (IAST) selectivity of 36.0 for benzene/cyclohexane separation, and can produce 0.48 mmol g−1 cyclohexane with purity of +99% from 50:50 (v:v) benzene/cyclohexane mixture under dynamic condition, higher than reported separation materials. Optimizing the pore size of COFs by isoreticular contraction strategy can trigger the pore confinement effect for better meeting the separation challenge in industry.
Atomically Precise Metal–Metal Oxide Interface in Polyoxometalate‐Noble Metal Hybrid Clusters
Authors: Wang Hai‐Ning , Meng Xing , Cao Yitao , Li Shun‐Li , Lan Ya‐Qian 
Published: November 2024

AbstractMetal‐metal oxide hybrid materials, typically composed of metal nanoparticles anchored on metal oxides matrix, are devoted enormous attentions as famous heterogeneous catalysts. The interactions between noble metals and metal oxides as well as their interfaces have been proven to be the origin of their excellent catalytic performance. Deep understandings on the interactions between noble metals and metal oxides at atomic precision, thus to precisely assess their contributions to catalysis, can serve as basic principles for catalyst design. In recent years, polyoxometalates (POMs), which in principle can be regarded as atomically precise metal oxide clusters, have been shown to have strong affinity to noble metals, thus forming diverse kinds of POM‐noble metal hybrid clusters. Their well‐resolved atomically precise structures and hybrid nature promise them as ideal platforms to understand the interfaces and interactions between noble metals and metal oxides. In this review, metal‐metal oxide interface is classified into different categories based on the different configurations of hybrid clusters, and aims to understand the interface structures and electronic correlations between POMs and noble metals at the atomic precision. Based on these basic understandings, the study provides the perspectives on the challenges and research efforts to be paid in the future.
Long‐term outcomes following the resection of screen‐detected right‐sided colon cancer
Authors: Lucocq James , Trinder Thomas , Symeonidou Elli , Homyer Katy , Baig Hassan , Patil Pradeep , Muthukumarasamy Girivasan 
Published: November 2024

AbstractBackgroundThe relative outcomes following the resection of screen‐detected right‐sided colon cancer compared to symptomatic cases are unknown. In this study, short and long‐term outcomes after right‐sided colectomy in screen‐detected colon cancer are compared with symptomatic cases, both emergency and elective.MethodsA prospective observational cohort study of patients, including both screen‐detected and symptomatic patients (elective and emergency resections), undergoing right‐sided colectomy for colon cancer (2010–2020) in a tertiary care unit was conducted. Each patient was followed up for long‐term recurrence and survival.ResultsA total of 909 patients (median age, 70; IQR, 58–82; male, 52%) were included (151 patients (16.6%) screen‐detected; 598 (65.8%) elective and 160 (17.6%) emergency). Screen‐detected patients were more likely to have T1 or T2 lesions compared to elective and emergency groups (T1: 14.6% vs. 3.8% vs. 0.6% p < 0.001; T2: 16.6% vs. 8.9% vs. 3.1% p < 0.001), but were less likely to have T3 or T4 lesions (p < 0.001), respectively. Rates of N0 were higher in the screen‐detected group (68.9% vs. 63.5% vs. 41.9%, respectively; p < 0.001). 98% of the screen‐detected group achieved R0 resection compared to 93.3% of elective and 79.4% of emergency patients (p < 0.001). At 5‐years following resection, overall survival for the screen‐detected, elective, and emergency groups were 85.4%, 75.4%, and 53.1%, respectively (p < 0.001). Recurrence at 5‐year post‐resection were 8%, 15.1%, and 22.5% for the screen‐detected, elective, and emergency groups, respectively (p < 0.001).DiscussionWhen considering right‐sided colon cancer alone, screen‐detected cancers have a lower long‐term recurrence rate, lower rates of postoperative complication, and superior survival compared to symptomatic groups following resection.