bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multifaceted framework for adoption of cloud computing in Malaysian SMEs
Authors: Asiaei Arash , Ab. Rahim Nor Zairah 
Published: August 2019

PurposeThe purpose of this study is to develop a model to understand the relationships among technology, organizational and environmental (TOE) contexts, intention to adopt cloud computing (IACC) and actual usage of cloud computing (AUCC) in small and medium enterprises (SMEs) in Malaysia as a developing country. More specifically, this paper seeks to explore the mediation effect of IACC on the relationship between TOE context and AUCC.Design/methodology/approachA positivist research approach was selected for this study. Drawing largely upon the TOE framework, this study uses survey data from 209 Malaysian SMEs. Structural equation modelling (SEM) based on partial least squares (PLS) was used to assess the structural relations of the research model.FindingsThe results of the structural model show that data security, technology readiness, top management support, competitive pressure and innovativeness are the most significant factors in predicting the adoption of cloud computing in Malaysian SMEs. Further, the results indicate that intention to adopt cloud computing can play a mediating role between TOE factors and the actual usage of cloud computing.Research limitations/implicationsThe focus upon Malaysian SMEs may diminish the generalizability of the findings. This study provides profound insight into the management and foundation of cloud computing, different types of cloud services and deployment models that could facilitate the management of enterprise strategic resources and contribute to the performance improvement. This study also provides another important implication for practitioners regarding the absolute necessity of value drivers’ identification within enterprise and understand the causal relationships, which are vital in driving those values.Practical implicationsThis study provides several practical guidance for practitioners in deploying cloud services which are most suitable option for their specific technology requirement in their enterprise to enjoy the full benefits of their intangible assets. Another significant implication of this study lies in the fact that it may require a different emphasis on nature and adoption design when there is a higher level of stress on technology-related and cloud computing resources.Originality/valueThis study contributes to the extant literature by developing an integrative model to identify how a wide set of contextual factors can determine the intention to adopt cloud computing and, in turn, influence the actual usage of cloud computing in SMEs in Malaysia as a developing country.
Sustainability disclosures of hybrid organizations: Swedish state-owned enterprises
Authors: Argento Daniela , Grossi Giuseppe , Persson Kamilla , Vingren Theres 
Published: August 2019

PurposeThe purpose of this paper is to explore the content of the sustainability reports of state-owned enterprises (SOEs) and the factors influencing the sustainability information they disclose.Design/methodology/approachDrawing upon the literature on sustainability disclosure, institutional logics and hybrid organizations, several hypotheses were deduced. By means of a quantitative content analysis, the sustainability disclosure index of 45 Swedish SOEs was calculated. Statistical analyses were conducted to test which variables affected the sustainability disclosures of the selected SOEs.FindingsThe findings reveal that only state ownership and corporate size significantly affect SOEs’ sustainability disclosures. Fully state-owned SOEs disclose less sustainability information than partially state-owned SOEs. Large SOEs disclose more sustainability information than small SOEs. However, there are weak indications that having a public policy assignment (PPA) (activity) negatively influences environmental sustainability disclosures, and that having a majority of female directors on the board decreases the total sustainability information disclosed. In addition, the statistical analyses show that having state representatives on the board and being profitable may positively affect the disclosures.Originality/valueAccountability is particularly important in SOEs, and their complex hybrid nature has an impact on sustainability disclosures in a surprising way. State ownership and control do not necessarily imply an increased amount of sustainability disclosure.
Internal environment of footwear is a risk factor for tinea pedis
Authors: Sasagawa Yukio 
Published: August 2019

AbstractThe relation between tinea pedis and the internal environment of footwear has not been scientifically proven. This study aimed to determine whether the internal environment of footwear affects the incidence of tinea pedis and tinea unguium. This cross‐sectional, observatory study involved 420 outpatients who were categorized into non‐tinea, tinea pedis or tinea unguium groups based on mycological analysis. External climatic conditions, and temperature, humidity and dew points inside the patients’ footwear were recorded. Univariate and multivariate analyses were used to determine independent risk factors for tinea pedis and tinea unguium. A significant correlation was found between high temperature/high humidity and dew point of the internal environment of the footwear and the season. Furthermore, those who wore footwear with internal environments characterized by high temperature, high humidity, high‐temperature/high‐humidity and high dew point values had a significantly higher incidence of tinea pedis. The internal dew point correlated with the incidence of tinea pedis, whereas the external temperature correlated with the incidence of tinea unguium. The internal humidity and dew point of footwear as well as the frequency with which footwear with a high‐temperature/high‐humidity internal environment were worn was significantly higher in men than in women. In conclusion, the internal environment of footwear is a risk factor for tinea pedis, and this environment is affected by the season. Moreover, the frequency of tinea pedis among men is related to the internal environment of footwear. The dew point is an appropriate index for evaluating temperature and humidity in relation to tinea pedis.
The microbiome of theMelitaea cinxiabutterfly shows marked variation but is only little explained by the traits of the butterfly or its host plant
Authors: Minard Guillaume , Tikhonov Gleb , Ovaskainen Otso , Saastamoinen Marjo 
Published: August 2019

SummaryUnderstanding of the ecological factors that shape intraspecific variation of insect microbiota in natural populations is relatively poor. In Lepidopteran caterpillars, microbiota is assumed to be mainly composed of transient bacterial symbionts acquired from the host plant. We sampled Glanville fritillary (Melitaea cinxia) caterpillars from natural populations to describe their gut microbiome and to identify potential ecological factors that determine its structure. Our results demonstrate high variability of microbiota composition even among caterpillars that shared the same host plant individual and most likely the same genetic background. We observed that the caterpillars harboured microbial classes that varied among individuals and alternated between two distinct communities (one composed of mainly Enterobacteriaceae and another with more variable microbiota community). Even though the general structure of the microbiota was not attributed to the measured ecological factors, we found that phylogenetically similar microbiota showed corresponding responses to the sex and the parasitoid infection of the caterpillar and to those of the host plant's microbial and chemical composition. Our results indicate high among‐individual variability in the microbiota of theM.cinxiacaterpillar and contradict previous findings that the host plant is the major driver of the microbiota communities of insect herbivores.
Geographic information system‐based edge effect correction for Ripley'sK‐function under irregular boundaries
Authors: Ge Ying , Sun Mengdi , Pu Yingxia 
Published: August 2019

AbstractRipley'sK‐function is a test to detect geographically distributed patterns occurring across spatial scales. Initially, it assumed infinitely continuous planar space, but in reality, any geographic distribution occurs in a bounded region. Hence, the edge problem must be solved in the application of Ripley'sK‐function. Traditionally, three basic edge correction methods were designed for regular study plots because of simplified geometric computation: the Ripley circumference, buffer zone, and toroidal methods. For an irregular‐shaped study region, a geographic information system (GIS) is needed to support geometric calculation of complex shapes. The Ripley circumference method was originally implemented by Haase and has been modified into a Python program in a GIS environment via Monte Carlo simulation (hereafter, the Ripley–Haase and Ripley–GIS methods). The results show that in terms of the statistical powers of clustering detection for irregular boundaries, the Ripley–GIS method is the most stable, followed by the buffer zone, toroidal, and Ripley–Haase methods. After edge effects of irregular boundaries have been eliminated, Ripley'sK‐function is used to estimate the degree of spatial clustering of cities in a given territory, and in this paper, we demonstrate that by reference to the relationship between urban spatial structure and economic growth in China.
Risk factors for shivering during caesarean section under spinal anaesthesia. A prospective observational study
Authors: Wódarski Bartłomiej , Chutkowski Radosław , Banasiewicz Jolanta , Moorthi Katarzyna , Wójtowicz Stanisław , Malec‐Milewska Małgorzata , Iohom Gabriella 
Published: August 2019

BackgroundShivering during caesarean section (CS) under spinal anaesthesia is a common phenomenon. It could not only alter patient's physiology by increasing oxygen consumption but also affect the parturient's experience of childbirth. Shivering is thought to be associated with intraoperative hypothermia, but the risk factors and exact mechanism remain unclear.MethodsWe conducted a prospective, observational study to examine the potential risk factors for intraoperative shivering, including anxiety levels. Two hundred patients undergoing elective CS under spinal anaesthesia were recruited. Parturient anxiety levels were evaluated using the State‐Trait Anxiety Inventory (STAI) questionnaire. Age, weight, height, BMI, anxiety level, number of previous deliveries, sensory block level, level of education, temperature difference during surgery and American Society of Anesthesiologists score were investigated as potential risk factors. Stepwise logistic regression was used to assess the predictors for shivering.ResultsData from 155 parturients were analysed. Shivering incidence was 21.9% (34 parturients). The statistical model predicted 8.5% of a shivering incidence variability (R‐square Nagelkerke = 0.085). Out of all measured variables, only the number of previous deliveries [(W) = 4.295 Exp(B) = 0.562 P < .05] and STAI‐X1 [(W) = 4.127 Exp(B) = 1.052 P < .05] were significant. In our model, the risk of shivering decreased by 44% with every previous delivery and increased by 5.2% with each 1‐point increase in STAI‐X1.ConclusionWe failed to prove a strong correlation between the measured variables and shivering. Our findings, however, support the hypothesis, that to a limited extent, anxiety promotes shivering during CS.
Stenting as a bridge to surgery for obstructed stage IV colorectal cancers – long‐term outcomes of a 10‐year study
Authors: Chok Aik Yong , Lim Hui Jun , Lye Weng Kit , Samarakoon Lasitha B , Guo Jiwei , Tang Choong Leong , Mathew Ronnie 
Published: August 2019

AbstractIntroductionSuccessful stenting of an obstructing colorectal tumor can avert upfront emergency surgery in malnourished obstructed patients with metastatic disease and poor physiological condition. This study aims to evaluate the outcomes of stenting followed by primary colorectal tumor resection among patients with obstructed stage IV colorectal cancer at presentation, over a 10‐year period.MethodsFrom 2007 to 2016, a cohort comprising 25 consecutive patients were retrospectively reviewed from a prospectively collected database. The durability of palliation of bowel obstruction, oncological outcomes and factors influencing overall survival were analyzed.ResultsNo re‐interventions were required for bowel obstruction during the study period. The overall perioperative morbidity rate was 16%, with no postoperative 90‐day mortality. Laparoscopic resection rate was 52% and stoma formation rate was 8%. The median overall survival was 24 months for the entire cohort, and the 1‐, 3‐ and 5‐year survival rates were 80%, 35% and 23.33% respectively. More than one site of distant metastases, peritoneal involvement, and elevated carcinoembryonic antigen levels were significantly associated with poorer survival outcomes. Patients with peritoneal‐only metastasis had worse outcomes, with a median survival of 7 months and no patients surviving beyond 18 months.ConclusionStenting followed by resection of the primary obstructing colorectal cancer provides durable palliation among patients with stage IV disease, with low perioperative morbidity and stoma formation rates. Superior survival was observed among patients with single‐site, non‐peritoneal distant metastases.
Prediction and validation of potent peptides against herpes simplex virus type 1 via immunoinformatic and systems biology approach
Authors: Mehmood Aamir , Kaushik Aman Chandra , Wei Dong‐Qing 
Published: August 2019

AbstractThe human herpes simplex virus type 1 (HSV‐1) is an extremely rampant human pathogen, and its infection could cause life‐long diseases, including the central nervous system disorders. The glycoproteins of HSV‐1 such as glycoprotein B, glycoprotein C, glycoprotein D, glycoprotein H, and glycoprotein L are highly involved in mediating the viral attachment and infection of the host cell. Therefore, immunoinformatic approaches followed by molecular dynamics simulation and systems biology has been used to analyze these glycoproteins in order to propose effective peptide‐based vaccine candidates against the HSV‐1 infection. The ElliPro and NetCTL.1.2 online tools were employed to forecast the B‐ and T‐lymphocyte (CTL) epitopes for gB, gC, gD, gH, and gL. The 3D coordinates of these epitopes were modeled and docked against the human major histocompatibility complex molecule‐1. The outcomes obtained from postdocking analysis along with TAP (Transporter associated with antigen processing), MHC binding, and C‐terminal cleavage score assisted in the selection of potential epitopes. These epitopes were further subjected to molecular dynamics simulation and systems biology approach which showed significant results. On the basis of these substantial outcomes, peptides are proposed that could be used to provoke immunity against the HSV‐1 infection.
Discovery of potential Toxoplasma gondii CDPK1 inhibitors with new scaffolds based on the combination of QSAR and scaffold‐hopping method with in vitro validation
Authors: Zhang Pengyi , Jia Lipei , Tian Yafei , Xi Lili , Duan Ruizhi , Chen Ximing , Xiao Jianxi , Yao Xiaojun , Lan Jingfeng , Li Shuyan 
Published: August 2019

AbstractTo discover drugs for toxoplasmosis with less side‐effects and less probability to get drug resistance is eagerly appealed for pregnant women, infant or immunocompromised patients. In this work, using TgCDPK1 as drug target, we design a method to discover new inhibitors for CDPK1 as potential drug lead for toxoplasmosis with novel scaffolds based on the combination of 2D/3D‐QSAR and scaffold‐hopping methods. All the binding sites of the potential inhibitors were checked by docking method, and only the ones that docked to the most conserved sites of TgCDPK1, which make them have less probability to get drug resistance, were remained. As a result, 10 potential inhibitors within two new scaffolds were discovered for TgCDPK1 with experimentally verified inhibitory activities in micromole level. The discovery of these inhibitors may contribute to the drug development for toxoplasmosis. Besides, the pipeline which is composed in this work as the combination of QSAR and scaffold‐hopping is simple, easy to repeat for researchers without need of in‐depth knowledge of pharmacology to get inhibitors with novel scaffolds, which will accelerate the procedure of drug discovery and contribute to the drug repurposing study.
A novel technique with double catheter suctioning for clearing away the left lung atelectases: Selective left bronchial aspiration (SeLBA)
Authors: Ozturk Zeynelabidin , Bayrakci Benan 
Published: August 2019

AbstractIntroductionAtelectasis is a common problem in intensive care units. It usually occurs due to airway obstruction caused by pulmonary secretions. As the left main bronchus angulates from carina more sharply, suctioning of the secretions from left side is less effective, causing failure in treatment of left lung atelectases. If chest physiotherapy and medical treatment fail, bronchoscopy should be considered; but it requires experience, time, effort and a higher cost.ObjectivesTo evaluate the success of a novel method “selective left bronchial aspiration (SeLBA)” in the treatment of left lung atelectases.MethodsThe study consisted of 10 patients who suffered left lung atelectasis and treated with double catheter suctioning technique, SeLBA in Pediatric Intensive Care Unit of Hacettepe University Ihsan Dogramaci Children's Hospital between June 2017 and February 2019. The outcomes were evaluated by comparing the chest X‐rays before and after the procedure.ResultsAll of the patients' atelectases resolved successfully by SeLBA procedure.ConclusionWe introduce this novel technique of reopening the atelectased left lung as a rapid, safe and practical alternative for bronchoscopic clear away.
Extra‐respiratory symptoms in patients hospitalized for a COPD exacerbation: Prevalence, clinical burden and their impact on functional status
Authors: Antoniu Sabina Antonela , Apostol Anca , Boiculese Lucian Vasile 
Published: August 2019

AbstractIntroductionIn COPD management, the improvement of the health status by alleviating respiratory symptoms is among the main aims. However, little is known on the prevalence and burden of extra‐respiratory symptoms which can also be distressing especially during a COPD exacerbation.ObjectivesTo evaluate the prevalence of extra‐respiratory symptoms and their impact on health and functional statuses in patients hospitalized for a COPD exacerbation.MethodsHealth status was evaluated with the COPD Assessment Test (CAT), functional status with Karnofsky index, and presence and severity of respiratory symptoms were evaluated with Edmonton Symptom Assessment Scale (ESAS).ResultsIn a sample of 47 patients, fatigue was found to be the most prevalent 95.7% followed by pain 74.5%, lack of appetite 72.3%, depression and anxiety (each in 63.8%), drowsiness 59.6% and nausea 31.9%. The concomitant presence of an increasing number of symptoms (three, four, five, six or seven) was individually associated with worse health status or of functional status (eg, CAT score in patients with three most prevalent symptoms, fatigue, pain and lack of appetite 29.6 vs 25.1, P = .006 in patients without them; Karnofsky index scores in patients with the four most prevalent symptoms 52 vs 65.6, P = .001). Linear regressions confirmed that the increase in the number of concomitant extra‐respiratory symptoms significantly correlated with the worsening of health/functional status. In conclusion, the burden of extra‐respiratory symptoms in patients with hospitalized for a COPD exacerbation is significant and impact significantly on health/functional status.
Acquired cutis laxa secondary to Sweet syndrome in a child (Marshall syndrome): A rare case report
Authors: Jagati Ashish , Shrivastava Shivank , Baghela Bhavna , Agarwal Pooja , Saikia Siddhartha 
Published: August 2019

AbstractSweet syndrome is rare in the pediatric population and usually responds well to treatment, resolving without sequelae. Marshall syndrome is a rare pediatric skin disease characterized by loss of elastic tissue (cutis laxa) secondary to acquired, localized neutrophilic dermatitis without any internal organ involvement. Only few cases of Marshall syndrome (acquired cutis laxa type II) have been reported. Systemic steroids and dapsone show excellent results in Sweet syndrome. Although there is no satisfactory treatment for cutis laxa, dapsone can be used in the acute phase for control of swelling.
Are beavers a solution to the freshwater biodiversity crisis?
Authors: Law Alan , Levanoni Oded , Foster Garth , Ecke Frauke , Willby Nigel J. 
Published: August 2019

AbstractAimTo determine whether reintroduced beavers, as an example of native herbivorous megafauna, can increase freshwater biodiversity at the landscape scale and to compare effects on two contrasting taxonomic groups.LocationSouth‐central Sweden.MethodsWe collected data on plant and water beetle composition and supporting environmental variables from 20 closely located wetlands, half created from the damming of streams by beavers—beaver ponds (BP), and half by other, mainly natural (e.g. topographic, river migration) means—other wetlands (OW). Differences in species composition and plant growth strategy (i.e. competitor, stress tolerator or ruderal) between wetland types were assessed using multivariate analyses.ResultsThe species pool of both taxonomic groups was higher in BP than OW (plants + 17%; beetles + 15%). For both groups, the number of species unique to BP was 50% higher than those unique to OW. Plant and beetle compositions differed significantly between wetlands, most strongly for plants, while rarity scores showed no difference, and the incidence of invasive species was negligible. Plant composition was mostly influenced by open water, bare ground and woody debris in BP, and plant cover, height and leaf litter in OW. This was consistent with the characterization of BP vegetation by ruderal plants and OW by competitors and stress tolerators. A significant residual effect of wetland type on plant, but not beetle composition, suggests that beavers exert important direct effects on some biota (e.g. via herbivory) independent of the indirect effects they exert via environmental change.Main conclusionsBeaver‐created ponds support novel biodiversity that is not merely a subset of that found elsewhere in the same landscape. As such, re‐establishing beaver populations where they are native should benefit freshwater biodiversity, but effects may be context and taxon specific. Beavers alone cannot solve the freshwater biodiversity crisis, but recognizing the widespread importance of herbivorous megafauna in maintaining heterogeneity and creating novel habitat will be a positive step.