bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of microRNA in Houttuynia cordata Thunb and prediction of cross kingdom functions
Authors: He Jiajian , Chen Ting , Xi Qingyun , Sun Jiajie , Luo Junyi , Li Meng , Zhang Haojie , Zeng Bin , Wu Jiahan , Zhang Yongliang 
Published: September 2019

Abstract
Houttuynia cordata Thunb (Family: Saururaceae) is well known as a traditional medicine plant and widely spread in China, Japan and India. It had been reported to have potential functions such as anti-bacterial, anti-cancer, and anti-inflammatory in human. Recently, it has been reported that the plant-derived microRNA(miRNA) possibly transported from one species to another and exerted a cross kingdom regulation, and miRNA has been considered as medicinal ingredents in herbs. However, knowledge is still rare about miRNAs in H. cordata. In this study we identified 163 conserved miRNAs and 30 novel miRNAs by high-throughput sequencing, and then randomly selected miRNA’s expression trend was identified by q-PCR, which was consistent with the sequencing result. Further bioinformatics analyses showed that the targets of H. cordata miRNAs were enriched in endocrine and other factor-regulated calcium reabsorption pathways, melanogenesis, insulin signaling pathway, and aldosterone -regulated sodium reabsorption pathways. These results will be helpful to understand new active components in H. cordata as food and traditional Chinese medicine. This study is the first report of miRNAs in H. cordata, and provides valuable data for further understanding the cross kingdom function of active components in H.cordata.
Prognostic Significance of MYC Rearrangement and Translocation Partner in Diffuse Large B-Cell Lymphoma: A Study by the Lunenburg Lymphoma Biomarker Consortium
Authors: Rosenwald Andreas , Bens Susanne , Advani Ranjana , Barrans Sharon , Copie-Bergman Christiane , Elsensohn Mad-Helenie , Natkunam Yaso , Calaminici Maria , Sander Birgitta , Baia Maryse , Smith Alexandra , Painter Daniel , Pham Luu , Zhao Shuchun , Ziepert Marita , Jordanova Ekaterina S. , Molina Thierry J. , Kersten Marie José , Kimby Eva , Klapper Wolfram , Raemaekers John , Schmitz Norbert , Jardin Fabrice , Stevens Wendy B.C. , Hoster Eva , Hagenbeek Anton , Gribben John G. , Siebert Reiner , Gascoyne Randy D. , Scott David W. , Gaulard Philippe , Salles Gilles , Burton Catherine , de Jong Daphne , Sehn Laurie H. , Maucort-Boulch Delphine 
Published: September 2019

PURPOSE MYC rearrangement ( MYC-R) occurs in approximately 10% of diffuse large B-cell lymphomas (DLBCLs) and has been associated with poor prognosis in many studies. The impact of MYC-R on prognosis may be influenced by the MYC partner gene (immunoglobulin [IG] or a non-IG gene). We evaluated a large cohort of patients through the Lunenburg Lymphoma Biomarker Consortium to validate the prognostic significance of MYC-R (single-, double-, and triple-hit status) in DLBCL within the context of the MYC partner gene. METHODS The study cohort included patients with histologically confirmed DLBCL morphology derived from large prospective trials and patient registries in Europe and North America who were uniformly treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone therapy or the like. Fluorescence in situ hybridization for the MYC, BCL2, BCL6, and IG heavy and light chain loci was used, and results were correlated with clinical outcomes. RESULTS A total of 5,117 patients were identified of whom 2,383 (47%) had biopsy material available to assess for MYC-R. MYC-R was present in 264 (11%) of 2,383 patients and was associated with a significantly shorter progression-free and overall survival, with a strong time-dependent effect within the first 24 months after diagnosis. The adverse prognostic impact of MYC-R was only evident in patients with a concurrent rearrangement of BCL2 and/or BCL6 and an IG partner (hazard ratio, 2.4; 95% CI, 1.6 to 3.6; P < .001). CONCLUSION The negative prognostic impact of MYC-R in DLBCL is largely observed in patients with MYC double hit/triple-hit disease in which MYC is translocated to an IG partner, and this effect is restricted to the first 2 years after diagnosis. Our results suggest that diagnostic strategies should be adopted to identify this high-risk cohort, and risk-adjusted therapeutic approaches should be refined further.
Εξ αποστάσεως Επιμόρφωση Δασκάλων. Εφαρμογή, Στατιστική Ανάλυση και Αποτίμηση.
Authors: Στρίγκας Κωνσταντίνος Πέτρος , Τσιμπίρης Αλκιβιάδης 
Published: September 2019

Σκοπός της εργασίας είναι η διερεύνηση της επίδρασης της εξ αποστάσεως εκπαίδευσης στη διαδικασία επιμόρφωσης των δασκάλων. Έγινε καταγραφή των απόψεων των 89 εκπαιδευτικών Πρωτοβάθμιας Εκπαίδευσης, μετά από τη συμμετοχή τους σε προγράμματα εξ αποστάσεως επιμόρφωσης. Πραγματοποιήθηκαν δύο προγράμματα εξ αποστάσεως επιμόρφωσης από δύο Σχολικούς Συμβούλους της 1ης και 2ης Εκπαιδευτικής Περιφέρειας Σερρών, με χρήση της πλατφόρμας ασύγχρονης εκπαίδευσης OpeneClass και της πλατφόρμας σύγχρονης εκπαίδευσης BigBlueButton. Το πρώτο πρόγραμμα είχε ως θέμα «Στρατηγικές-Μέθοδοι-Τεχνικές Διδασκαλίας» και το δεύτερο «Θετική ψυχολογία και Συναισθήματα στην εκπαίδευση». Η συμμετοχή στο δεύτερο πρόγραμμα παρουσιάστηκε διπλάσια σχετικά με το πρώτο. Με την ολοκλήρωση σε καθένα από τα προγράμματα υλοποιήθηκε έρευνα με ερωτηματολόγια ερωτήσεων κλειστού τύπου μέσω της πλατφόρμας, ώστε να καταγραφούν οι στάσεις και οι απόψεις των δασκάλων για την εμπειρία τους κατά την διάρκεια της τηλεπιμόρφωσης καθώς και τα συμπεράσματα τους για την υλοποίηση εξ αποστάσεως επιμορφώσεων γενικότερα. Στα αποτελέσματα, μεγάλο ενδιαφέρον παρουσιάζει η επιθυμία και η εμπιστοσύνη του μεγαλύτερου μέρους των συμμετεχόντων στις εξ αποστάσεως επιμορφώσεις, καθώς και οι θετικές σκέψεις των εκπαιδευτικών για περεταίρω χρήση διαδικτυακών χώρων υποστήριξης εξ αποστάσεως εκπαίδευσης.
Drunk Without Drinking: A Case of Auto-Brewery Syndrome
Authors: Akhavan Bobak J. , Ostrosky-Zeichner Luis , Thomas Eric J. 
Published: September 2019

ABSTRACT
Information on auto-brewery syndrome is limited in the medical literature. This rare syndrome occurs when yeast overgrowth leads to ethanol fermentation in the gut. We present a patient presenting with symptoms of alcohol intoxication with objective laboratory data of elevated blood ethanol levels without a history of alcohol consumption. We reviewed the literature and have discussed the current diagnostic and therapeutic options.
Metabolically Healthy Obesity and the Risk of Erosive Esophagitis: A Cohort Study
Authors: Kim Tae Jun , Lee Hyuk , Baek Sun-Young , Kim Kyunga , Min Yang Won , Min Byung-Hoon , Lee Jun Haeng , Son Hee Jung , Rhee Poong-Lyul , Kim Jae J. 
Published: September 2019

OBJECTIVES:
Obesity is an established risk factor of erosive esophagitis, and metabolic unhealthiness has been implicated in the pathogenesis of erosive esophagitis. Yet, the risk of erosive esophagitis among obese individuals without obesity-related metabolic unhealthiness, a condition referred to as “metabolically healthy obese (MHO)”, remains unclear. We examined the association between body mass index (BMI) categories and the development of erosive esophagitis in a cohort of metabolically healthy individuals.

METHODS:
We conducted a cohort study of 14,725 asymptomatic adults free of erosive esophagitis and metabolic abnormalities, who underwent repeated health checkups including screening endoscopy. A metabolically healthy state was defined as having no metabolic syndrome components and a homeostasis model assessment of insulin resistance <2.5. The presence of erosive esophagitis was determined using endoscopy.

RESULTS:
During 81,385.2 person-years of follow-up, 1,865 participants developed erosive esophagitis (incidence rate, 22.9 per 1,000 person-years). The multivariable adjusted hazard ratios (95% confidence intervals) for incident erosive esophagitis comparing overweight (BMI 23.0–24.9) and obese (≥25) with normal-weight participants (18.5–22.9) were 1.12 (1.00–1.25) and 1.29 (1.14–1.47), respectively. In dose-response analyses, increasing BMI also showed positive association with overall and LA-B grade or higher. The association persisted in MHO individuals without central obesity. The association between waist circumference categories and the development of erosive esophagitis was also evident.

DISCUSSION:
In a large cohort of strictly defined metabolically healthy men and women, the MHO phenotype was associated with an increased incidence of erosive esophagitis, providing evidence that the MHO phenotype is not protective from gastroesophageal reflux disease.
Countermovement Jump and Drop Jump Performances Are Related to Grand Jeté Leap Performance in Dancers With Different Skill Levels
Authors: Blanco Penelope , Nimphius Sophia , Seitz Laurent B. , Spiteri Tania , Haff G. Gregory 
Published: September 2019

Abstract
Blanco, P, Nimphius, S, Seitz, LB, Spiteri, T, and Haff, GG. Countermovement jump and drop jump performances are related to grand jeté leap performance in dancers with different skill levels. J Strength Cond Res 35(12): 3386–3393, 2021—Thirty-five classical ballet dancers were chosen to investigate relationships between the grand jeté leap, countermovement jump (CMJ), and drop jump (DJ) and establish whether the magnitude of the relationship between these tests differed across 3 skill levels. Subjects (male: n = 11 and female: n = 24) were divided into 3 groups: novice (n = 12; age: 16.6 ± 1.5 years; height: 1.7 ± 0.1 m; body mass: 58.0 ± 13.0 kg), semiprofessional (n = 13; age: 20.0 ± 1.6 years; height: 1.7 ± 0.1 m; body mass: 64.1 ± 10.5 kg), and professional (n = 10; age: 23.8 ± 3.5 years; height: 1.8 ± 1.2 m; body mass: 63.3 ± 14.7 kg). Grand jeté leap height, followed by CMJ and DJ vertical displacement, was assessed. Significant relationships were found between the grand jeté, CMJ (r = 0.77, p = 0.001) and DJ (r = 0.76, p = 0.001). After a Fisher's r-z transformation, professional dancers and novice dancers showed greater r-value differences in CMJ (r
2 − r
1 = 0.27) compared with novice (r
2 − r
1 = 0.17) and semiprofessional dancers (r
2 − r
1 = 0.11), indicating larger strength of CMJ to grand jeté relationship in professionals. The grand jeté leap showed large to very large correlations with CMJ and DJ within groups. These common performance tests were determined to be practical and efficient methods for assessing the jumping ability of dancers. As dance skill increased, larger correlations were observed, suggesting that dancers with superior ballet skills may be more likely to use their underpinning physical capacities to jump higher within the context of ballet-specific jumping.
Foraging plasticity of Atta cephalotes (Hymenoptera: Formicidae) in response to temperature differences between forest and pasture
Authors: Bustamante Santiago , Amarillo-Suárez Angela 
Published: September 2019

Introduction: Changes in microclimatic conditions due to land cover transformations influence variations in population life histories and the developmental patterns of organisms. These variations can have either a genetic basis, an environmental basis, or both. Objective: To determine the differences between habitats in the foraging activity of Atta cephalotes in response to changes in temperature and the extent to which any such differences are due to phenotypic plasticity, genetic variability, or both. Methods: We performed foraging experiments; each colony (4 colonies sourced from pasture and 3 colonies sourced from forest) underwent eight temperature treatments from 10 to 45 ºC (± 1 ºC) at 5 ºC intervals, using common garden and reciprocal transplant experiments. Results: We found high plasticity in the foraging activity of Atta cephalotes in response to temperature, with the foraging activity gradually increasing from 15 ºC to 35 ºC. Additionally, we found no significant differences in the foraging activity between the colonies sourced from the pasture and forest. Conclusions: The foraging activity of A. cephalotes was directly proportional to temperature, with ants exhibiting thermophilic behaviors and high plasticity, and there were no differences in the foraging activity between colonies sourced from both habitats.
Inadekvát, aránytalan sinuscsomó-tachycardia. Egy régi szívritmuszavar új megvilágításban
Authors: Borbola József , Földesi Csaba , Kardos Attila , Som Zoltán 
Published: September 2019

Abstract: Introduction: The inadequate, inappropriate sinus-node tachycardia is not a rare clinical syndrome, defined as a non-paroxysmal, increased sinus-rate at rest, and/or inadequate response to physical and/or emotional stress, and palpitations. Aim: The aim of this study was to describe our experiences with the investigations of our inappropriate sinus-node tachycardia patients. Method: In the last years, 104 patients (92 women, 12 men, mean age: 31 ± 10 years) were treated with this cardiac arrhythmia entity. All patients underwent 12 leads ECG, chest X-ray, echocardiography, Holter-monitoring and transtelephonic ECG observations. The quality of life score was estimated by using the European Heart Rhythm Association scale. Results: Patients had no structural heart disease (physical examination ECG, chest X-ray, echocardiography were normal), the laboratory values (TSH, blood count) were within normal limits, but the resting heart rates were repeatedly high (102 ± 8/min). The results of Holter recording (expressed as minimal-maximal [average] heart rate/min) without drug therapy showed high heart rate values (59 ± 8, 160 ± 14 [94 ± 6]/min). The standard bicycle ergometry showed an average loading capacity of 124 ± 23 watt (heart rate: control: 99 ± 12/min, top: 167 ± 13/min) with early, inadequate sinus tachycardia. To disclose the episodes of paroxysmal supraventricular tachycardia, beside the Holter-monitoring transtelephonic ECG system was used. This diagnostic modality was very useful for the exclusion of paroxysmal supraventricular tachycardia episodes during the palpitation symptoms. Out of 104 patients, 4 patients (3.8%) showed familiar occurrence, another 16 patients (15.2%) had previous slow-pathway radiofrequency ablation due to atrioventricular nodal reentry tachycardia. Conclusions: Based on our clinical observations, it can be pointed out that inappropriate sinus-node tachycardia syndrome (1) occurs mainly in young women, mostly in students, inducing decreased quality of life scores (EHRA score: 2.3 ± 0.4); (2) the prevalence in our outpatient clinic was 0.7%; (3) the patient population is not homogeneous: familiar or postablation occurrence is possible in some patients; (4) transtelephonic ECG has been proved to be very useful to disclose episodes of paroxysmal supraventricular tachycardia in these patients. Orv Hetil. 2019; 160(37): 1464–1470.
A dystrophia myotonica 1-es típusának sokszervi megjelenése
Authors: Varga Dávid , Pál Endre 
Published: September 2019

Abstract: Myotonic dystrophy is one of the most common, autosomal dominantly inherited adult-onset muscle disorders. Two types of the disease are known: type 1 is characterized by distal weakness and myotonia, but type 2 is associated with proximal weakness and milder clinical course. It is also called as Steinert Disease, which affects the heart conduction system, the internal secretional glands, the ocular lens as well as carbohydrate-, fat metabolism and gonadal functions. These systemic symptoms have high impact on the quality of life and might impact on patients’ survival. Here we would like to emphasize these clinical conditions and the diagnostic possibilities. We hope our recommendations can help neurologists and general practitioners to achieve an optimal and individual care for patients suffering from this muscle disease. Orv Hetil. 2019; 160(37): 1447–1454.
Movimientos juveniles y políticas públicas de juventud en México: una aproximación conceptual
Authors: González García Robert , Belmonte Juan Antonio Taguenca 
Published: September 2019

En los últimos años emergen en México nuevas formas de participación política juvenil. Sin embargo las políticas públicas de juventud siguen abordando la atención a las problemáticas juveniles sin su participación y de forma deficitaria. El objetivo del artículo es trazar un marco conceptual y empírico que permita pensar unas políticas públicas de juventud desde y para los mismos jóvenes mexicanos. La metodología es el análisis documental y la hermenéutica de los procesos sociales que protagonizan los jóvenes mexicanos en los ámbitos de la participación política en los últimos años, entrecruzándolo con el análisis de la respuesta de las administraciones en forma de políticas de juventud. Los resultados son la emergencia de una juventud más participativa, que sin embargo aún no muestra grandes cambios en su cultura política a nivel agregado y que convive con la persistencia de políticas públicas juveniles propias de periodos anteriores. La conclusión es que caminar hacia unas políticas públicas juveniles participativas es un objetivo importante para la democratización y mayor eficiencia de la atención a los jóvenes.
Clinical and laboratory evaluation of patients afflicted with allergic asthma under immunotherapy
Authors: Hade Falah Hasasn 
Published: September 2019

<p align="justify"><strong>Background</strong>: Allergy may be defined as a constellation of signs and symptoms in which the altered immunologic reaction between foreign substance (allergens) and antibodies resulting in pathologic reactions referred as allergic reactions.</p><p align="justify">Allergic asthma is well known type 1- allergic reaction Up to 30% of general population suffers from various form of this malady during normal life span .</p><p align="justify"><strong>Objective:</strong> To evaluate the effects of immunotherapy on groups of Iraqi people afflicted with allergic asthma through some clinical and laboratories tests</p><p align="justify"><strong>Methods: </strong>A cross sectional study was carried out on Iraqi patients ( males and famales) in AL-Zahraa Consultant Center for Allergy and Asthma in Baghdad - Karkh, between Nov. 2013 - Apr. 2014 .The study included 60 asthmatic patients ( 6 - 45 years old) whom had allergy to house mites antigens " through skin test ",in addition to 20 apparently healthy persons as control group.A subcutaneous immunotherapy was given for 3 months, starting from diluted doses which were increased gradually. Clinical assessment was done depending on scoring of signs and symptoms, in addition to the medical history , clinical investigation, skin test, and pulmonary function test .<strong></strong></p><p align="justify"><strong>Results:</strong> Study showed that asthma still affected all age group but tend to be higher in age group 31-45 years with male to female ratio 2:1. Family history to allergic disease play a major role 60% with increase prevalence of reactivity for indoor allergy (House Mites and Moulds).</p><p align="justify">66.7% had positive skin reaction to House Mites which includes D1 ,D2 and D1+D2. The dust found to be one of main aggravating factors. Medical condition had shown significant improvement after three months of giving immunotherapy.<strong></strong></p><p align="justify"><strong>Conclusion:</strong> Immunotherapy need to be considered as one of alternative treatment of allergic asthma decreasing the side effects and cost of different drugs used by these patients when given regularly to them, also detection of prevalent allergens in our local atmosphere and their concentration with detection of their seasonal distribution in different parts of our country is required.</p>
The Use of Single-Subject Design in Rehabilitation Counseling Research
Authors: Gerald Michael , Estrada-Hernández Noel , Wadsworth John 
Published: September 2019

BackgroundThe utility of single-subject designs as a practical methodology for rehabilitation professionals working in the field and one that allows researchers the flexibility to identify or change treatments in the event their participant or client is not responding has been established for nearly a century (Dixon, 2002). However, a content analysis of the presence of single-subject research in rehabilitation research has been absent from the rehabilitation literature.PurposeThe purpose of this article is to describe the usability of single study designs as a research tool that contributes to the identification of Evidence-Based Practices (EBPs) in rehabilitation counseling.MethodsThrough manual and electronic searches of the literature, the authors identified journals and subsequently articles that clearly stated the use of single-subject design as their method of data collection and analysis.ResultsBetween 2001 to 2016, there have been a total of eight articles published that have either utilized single-subject experimental designs or provided an overview of the methods.ConclusionsA critical review of the rehabilitation literature indicated that single-subject methodologies have been recognized as contributing to the identification of EBPs, yet studies utilizing a single-subject methodology continue to be rare. The paucity of single-subject design may be the result of a lack of training opportunities, lack of models in the rehabilitation literature, and assumptions that single-subject design utility is limited to behavioral research.
Comparative Analysis of Learning Outcomes for On-Campus and Distance Learning Courses in a Rehabilitation and Mental Health Counselor Education Program
Authors: Holmes Courtney , Reid Christine 
Published: September 2019

BackgroundDespite the increasing reliance in counselor education on online teaching and learning, the efficacy is not well documented.ObjectiveTo investigate learning outcomes for master's-level rehabilitation and mental health counseling students.MethodsThis study compared on-campus and online learning course delivery methods with pre-and post-tests using 41 participants across four courses.FindingsSignificant differences were found within both groups between the pre- and post-test, indicating significant gains in knowledge acquisition. No significant differences were found between group modalities in the magnitude of improvement in test scores.ConclusionsFindings suggest that no differences exist in these learning outcomes when online and on-campus teaching modalities are compared and that both modalities produce positive learning outcomes. Continued research is needed to address additional questions in this area.
Delayed Radial Nerve Injury from a Brachial Artery Pseudoaneurysm Following a Four-Part Proximal Humerus Fracture
Authors: Sungelo M.J. , Sears B.W. 
Published: September 2019

Case:
Following a 4-part proximal humerus fracture at the level of the surgical neck, an 84-year-old woman presented with delayed radial nerve deficits secondary to a brachial artery pseudoaneurysm. She underwent emergent repair of the vessel and reverse total shoulder arthroplasty. The deficit remained present at 1-year follow-up and is unlikely to improve.

Conclusions:
Brachial artery pseudoaneurysms can occur following humeral fractures. Fractures at this location can lead to the unique complication of a proximal pseudoaneurysm that compresses the radial nerve. It should be considered a possible limb-threatening complication in fractures managed conservatively as well as surgical candidates.