bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective randomized trial of genomic classifier impact on treatment decisions in patients at high risk of recurrence following radical prostatectomy (G-MINOR).
Authors: Morgan Todd Matthew , Miller David Christopher , Dunn Rodney , Susan Linsell , Okoth Linda , Johnson Anna , Feng Felix Y , Khurshid Ghani , Davicioni Elai , Du Plessis Marguerite , Montie James E. , Cher Michael L. 
Published: February 2018

TPS154 Background: Approximately 30% of patients will have ≥pT3 disease and/or positive surgical margins at radical prostatectomy (RP), indicating a high risk of local recurrence. While current guidelines recommend consideration of adjuvant radiotherapy (aRT) in this setting, < 10% undergo aRT. The Decipher assay is a novel, tissue-based genomic classifier (GC) developed and validated in the post-RP setting as a predictor of metastasis. Current retrospective evidence suggests that patients with a high GC score may benefit from aRT, while observation may be safe for those with a lower GC score. However, there are no randomized prospective data evaluating the clinical utility of biomarkers in men with adverse features after RP. Here we see to determine the impact of GC test results on adjuvant treatment decisions for high-risk post-RP patients vs. clinical factors alone. Methods: Genomics in Michigan ImpactiNg Observation or Radiation (G-MINOR) is a 4-year (12-month enrollment, 3-year follow-up) prospective, cluster-crossover, unblinded, study of 350 subjects from twelve Urology practices in the Michigan Urological Surgery Improvement Collaborative (MUSIC). MUSIC is a physician-led quality improvement consortium nearly all academic and community urology practices within the state of Michigan. Each clinical center participating in this trial will be randomly assigned to either a Genomic Classifier (GC)-based strategy or control arm for a period of 3 months. Patients in both arms will receive a predicted risk of recurrence based on a validated clinical nomogram, the CAPRA-S score, enabling a head-to-head comparison of the Decipher assay with a freely-available validated prognostic tool. Random assignments will be generated centrally by a study statistician and provided to centers immediately before commencing enrollment in each 3-month period. Each center will have two GC and two UC enrollment periods, maintaining study-wide balance and blinding of assignments in subsequent periods. Patients will be followed for receipt of adjuvant therapy as well as oncologic (recurrence, metastasis, and death) and patient-reported quality of life. Clinical trial information: NCT02783950.
Os movimentos contestatórios no Serviço Social iberoeuropeu e da América do Norte no período de 1960 a 1980
Authors: Eiras Alexandra Aparecida Leite Toffanetto Seabra , Yazbek Maria Carmelita , Santos Cláudia Mônica dos 
Published: February 2018

Resumo − Este artigo constitui-se como parte da pesquisa O Movimento de Reconceituação do Serviço Social na América Latina (Argentina, Brasil, Chile e Colômbia): determinantes históricos, interlocuções internacionais e memória. Nossa ênfase circunscreve-se a Portugal, Espanha, EUA e Canadá (1960-1980). Desse modo, pretendemos identificar as referências teórico-metodológicas do Serviço Social nesse período, em seus nexos com os “movimentos contestatórios” e com o “movimento de reconceituação latino-americano” (MRLA). Indagamos acerca da relação entre o MRLA e o Serviço Social crítico e/ou radical, considerando suas particularidades, antecedentes, expressões e desdobramentos. Apresentamos, assim, um panorama econômico, político, social e cultural da conjuntura desses países à época. Apresentamos, ainda, os movimentos do Serviço Social crítico e/ou radical e suas referências ético-políticas e teórico-metodológicas, as quais os distinguem do Serviço Social tradicional. Por fim, indicamos, quando pertinente, as interlocuções desses movimentos/produções com o MRLA. Palavras-Chave: Serviço Social; Movimento de Reconceituação latino-americano; movimentos contestatórios na Europa ibera e na América do Norte. Abstract − This article is part of the research “The Movement of Reconceptualization of Social Work in Latin America (Argentina, Brazil, Chile and Colombia): historical determinants, international interlocutions and memory.” Our emphasis is limited to Portugal, Spain, USA and Canada (1960-1980). In this research we intend to identify the theoretical-methodological references of social work in this period, in its links with the social contestation movements and with the Latin American reconceptualization movement (MRLA). We inquire about the relationship between the MRLA and the critical and radical social work, considering its particularities, antecedents, expressions and aftereffects. In this article, we present an economic, political, social and cultural panorama of the conjuncture of these countries at the time. We also present the movements of critical and radical social work and both their ethical-political and theoretical-methodological references, which distinguish them from traditional social work and indicate, when pertinent, the interlocutions of these movements and productions with the MRLA.Keywords: social work; Latin American reconceptualization movement; social contestation in Iberian Europe and North America.
Weather, Landscape, and Management Effects on Nitrate and Soluble Phosphorus Concentrations in Subsurface Drainage in the Western Lake Erie Basin
Authors: Pease Lindsay A. , Fausey Norman R. , Martin Jay F. , Brown Larry C. 
Published: February 2018

Abstract. Subsurface drainage, while an important and necessary agricultural production practice in the Midwest, contributes nitrate (NO3-N) and soluble phosphorus (P) to surface waters. Eutrophication (i.e., excessive enrichment of surface water by NO3-N and soluble P) supports harmful algal blooms in receiving waters. The magnitude of NO3-N and soluble P loss in subsurface drainage varies greatly by landscape, weather, and field management factors. This study evaluated both the relative and combined impacts of these factors on observed NO3-N and soluble P concentrations in subsurface drainage water in the Western Lake Erie Basin watershed. Water quality data from multiple drainage outlet sites in northwest Ohio provided evidence that the primary management factors affecting NO3-N and soluble P loss were the amount and time of fertilizer application. Results strongly support following Tri-State fertilizer recommendations and 4R nutrient stewardship principles to reduce the risk of NO3-N and soluble P loss. Results also provided evidence of NO3-N and soluble P transport to subsurface drains via different pathways. Due to differences in NO3-N and soluble P transport through the soil profile (via baseflow and preferential flow, respectively), management approaches taken to reduce one nutrient may exacerbate losses of the other. Further research is needed to address potential changes in field hydrology (and consequently the in-field transport of soluble nutrients) from different types of agricultural best management practices (BMPs) and to evaluate optimal stacking of BMPs to achieve reductions in both NO3-N and soluble P loss. Controlled drainage has a high potential for stacking with other BMPs because it is primarily a physical discharge and load reduction practice. Keywords: Agriculture, Eutrophication, Nutrient transport, Regression analysis, Water quality.
Is sarcopenia a useful predictor of outcome in patients after emergency laparotomy? A study using the NELA database
Authors: Trotter John , Johnston Judith , Ng Alvin , Gatt Marcel , MacFie John , McNaught Clare 
Published: February 2018

Introduction Studies have reported on the use of frailty as a prognostic indicator in patients undergoing elective surgery. Similar data do not exist for patients undergoing emergency surgery. The aim of this study was to evaluate the effect of preoperative sarcopenia measured by computed tomography (CT) on outcome following emergency laparotomy. Materials and methods Data from the National Emergency Laparotomy Audit database were retrieved for patients who had undergone an emergency laparotomy over 12 months at York NHS Foundation Trust. Sarcopenia was assessed by psoas density and area on preoperative CT. Mortality rates at 30 days and 1 year were recorded. Secondary outcomes included discharge rates to non-independent living. Results A total of 259 patients were included. Overall cohort 30-day and 1-year mortality was 13.9% (36/259) and 28.2% (73/259), respectively. Sarcopenia measured by psoas density was associated with increased mortality compared with patients who did not develop sarcopenia at 30 days (29.7%, 19/64, vs. 8.7%, 17/195; P < 0.001; odds ratio, OR, 4.42; 95% confidence interval, CI 2.13–9.26) and at 1 year (57.8%, 37/64, vs. 18.5%, (36/195; P < 0.001; OR 6.05; 95%CI 3.28–11.18). An increase in mortality was seen in patients with sarcopenia measured by psoas area at 30 days (21.3%, 13/61, vs. 9.1%, 17/187; OR 2.71; 95%CI 1.23–5.96, P = 0.013) and at 1 year (42.6%, 26/61, vs. 20.9%, 39/187; OR 2.82; 95% CI 1.52–5.23, P < 0.001). Conclusions Sarcopenia assessed by measurement of psoas density and area on CT is associated with increased mortality following emergency laparotomy. The use of sarcopenia as a predictive tool merits further attention and may be useful in patients undergoing emergency surgery.
The comparison of femoral component rotation in the total knee arthroplasty
Authors: Chmurny M , Krivanek S , Melisik M , Rovnak M , Necas L. 
Published: February 2018

AbstractIntroduction Background:Optimal femoral component rotation in total knee arthroplasty (TKA) is crucial to establish a balanced knee reconstruction. Unbalanced knees can lead to instability, patellofemoral problems, persistent pain, stiffness, and generally poorer outcomes including early failure. There are several methods to achieve the femoral component rotation such as balanced gap technique, measured resection technique, and bone landmarks such as transepicondylar line (TEA) and Whiteside line. The purpose of this study was to compare the balan ced gap technique with the TEA technique.Materials and Methods:This randomised prospective study compares the femoral component rotation obtained with the use of balanced gap technique and the TEA, as well as compares the differences due to preoperative knee desaxations. The study includes 50 knees, 19 with neutral alignment, 22 with varus, and 9 with valgus desaxation. The femoral component rotation was measured postoperatively on photodocumentation taken after determining the TEA and balanced gap technique line peroperatively. These lines were compared to the posterior femoral condyles obtaining the degree of rotation. In case of transepicondylar line it is condylar twist angle (CTA) and in case of ligament balancer rotation axis it is ligament balancer angle (LBA).Results:The statistically significant differences in femoral component rotation using the techniques mentioned above as well as differences in individual knee desaxations were observed. The average LBA was 3.42 degrees and average CTA 3.58 in neutral knees group, but in the varus knees the average CTA value was 2.27 degrees and LBA value was 1.05 degrees. The average CTA value in patients with valgus desaxation is 4.78 degrees and LBA value is 5.22 degrees. According to Tukey Post Hoc test a statistically significant difference in LBA value is between neutral and varus knees with a significance level of p = 0.000022 and the most significant difference between varus and valgus knees with a significance level of p = 0.000011.Conclusion:The statistically significant differences in femoral component rotation using the techniques mentioned above as well as differences in individual knee desaxations were observed.
The Notion of the Foreign in Hungarian and Bulgarian Phraseologisms
Authors: Lesnichkova Lilyana 
Published: February 2018

Abstract
The confrontation between the native and the foreign is a problem that focuses research efforts on a number of humanities, e.g. cultural studies, anthropology, linguistics, ethnography, etc. The following report analyses the notion of the foreign, the other, the different, reflected in the phraseological wealth of the Hungarian and Bulgarian languages. The reviewed phrasemes concentrate the shock upon collision with the different or evaluation of the experience gained in the continuous communication with the other. The foreign is usually individualized by outlining and exaggerating some of its characteristics using parallels, oppositions, and metaphors. The negative attitudes and judgments prevail over the others: the fear of the collective “I” losing its own identity creates a negative attitude towards the foreign, distorted, or wrong notion of the other and the different. Many of the idioms reflect interethnic relations from times long gone, and so they are no longer a significant part of the active vocabulary of Hungarians and Bulgarians. Their analysis, however, is of great interest as they preserve the collective memory of the Hungarian and Bulgarian cultural communities and reveal their traditional notions and knowledge.
Missing data in open-data era – a barrier to multiomics integration
Authors: Piwowar Monika , Jurkowski Wiktor 
Published: February 2018

Abstract
The exploration of complex interactions in biological systems is one of the main aims in nature science nowadays. Progress in this area is possible because of high-throughput omics technologies and the computational surge. The development of analytical methods “is trying to keep pace” with the development of molecular biology methods that provide increasingly large amounts of data – omics data. Specialized databases consist of ever-larger collections of experiments that are usually conducted by one next-generation sequencing technique (e.g. RNA-seq). Other databases integrate data by defining qualitative relationships between individual objects in the form of ontologies, interactions, and pathways (e.g. GO, KEGG, and String). However, there are no open-source complementary quantitative data sets for the biological processes studied, including information from many levels of the organism organization, which would allow the development of multidimensional data analysis methods (multiscale and insightful overviews of biological processes). In the paper, the lack of omics complementary quantitative data set, which would help integrate the defined qualitative biological relationships of individual biomolecules with statistical, computational methods, is discussed.
Going Along or Going Independent? A Dynamic Analysis of Nonprofit Alliances
Authors: Chen Jiawei , Sacks Michael 
Published: February 2018

Abstract
This paper investigates strategic alliances in the nonprofit sector in the form of franchising. Using a dynamic model of local public goods with endogenous affiliation and splitting, we show that local organizations may choose to affiliate with the national organization for faster capital accumulation. Temporary alliance occurs when a local organization strategically affiliates with the national organization only to break away after accumulating enough capital. Alliance is more likely to arise and persist when the local chapter is smaller, when the local chapter’s mission is closer to the national organization’s, when the national organization is more efficient in production, and when the local chapter is more patient. Moreover, regulation that requires the local chapter to be affiliated with the national organization would be welfare reducing when the local chapter is large, when the local and national missions differ substantially, and when production at the national organization is inefficient.
The Securitization of National Minorities in the Baltic States
Authors: Kuczyńska-Zonik Aleksandra 
Published: February 2018

Abstract
The occupation of Crimea and war in Eastern Ukraine brought minority issues to the top of the Baltic security agenda. Although experts estimate that a separatist scenario for Lithuania, Latvia and Estonia is not probable, the issue of national minorities has already been included into the security concept as a potential source of danger to stability and national identity. While there is need to analyze political risks in the Baltics, the concept of securitization will be applied to the topic of national minorities. This paper addresses the problem of national minorities’ political integration and loyalty to the state. For the empirical analysis, the paper will use secondary data of surveys conducted in 2014-2017, exposing opinions and beliefs of minorities in the Baltic States referring to their domestic and foreign policies, NATO, Ukrainian crisis and relations with Russia. As a result, the concluding suggestion is made that more attention should be paid to political cohesion and minority policy management: 1) to optimize the minority development; 2) to predict potential risks in the region, and 3) to prevent further threats from Russia.
Quality and Compliance in Short-Cycle Higher Education Programs in the Field of Real Estate Management
Authors: Lūce Intra 
Published: February 2018

Abstract
The article deals with the concept of quality and compliance in the context of the short-cycle professional higher education (SCHE) program in the field of real estate management. The article highlights the role of graduates and employers in assessing the quality and compliance and surveys of students as well. The surveys of students, graduates and employers and the analysis of legislation allow assessing the quality and compliance of SCHE study program in real estate management. Currently, in Latvia, the qualification of a house manager can be obtained at three accredited higher education institutions, studying in a short-cycle professional higher education program, which, in accordance with European Qualifications Framework (EQF), is the first-level professional higher education program. The article will mainly focus on the quality and compliance of the house managers’ professional qualification acquisition in short-cycle higher education programs in Latvia. Data analysis, synthesis and logical construction methods have been used in this article.
Diffuse pulmonary interstitial emphysema in a late preterm neonate without mechanical ventilation
Authors: Li Shuo , Still Gordon G. , Abdelbaki Ahmed , Hegde Rahul , Schwartz Dana 
Published: February 2018

Abstract
Pulmonary interstitial emphysema (PIE) is most commonly seen in the setting of preterm, low birth weight neonates with lung disease. It exists on a spectrum with pneumomediastinum and pneumothorax and is often a transient phenomenon. This condition has been rarely reported in neonates while only on nasal continuous positive airway pressure (CPAP) without mechanical ventilation, but only as a localized presentation. We present a case of a late preterm neonate with diffuse PIE complicated by bilateral pneumothoraces, requiring chest tubes, with congenital thyroid aplasia as well.
Upper estimate of a combinatorial sum
Authors: Roldugin Pavel V. 
Published: February 2018

Abstract
We give an upper estimate for the binomial sum

U

d

x

=

∑

r
≥
0

d
−
r
+
1

r

⋅

x

r

$\begin{array}{}
U_{d} \left(x\right)=\sum _{r\ge 0}\binom {d-r+1} r\cdot x^{r}
\end{array} $

with natural d and real nonnegative x. In particular, this estimate implies that

U

d

x

=
O

(

(
0.5
+

x
+
0.25

)

d

)

$\begin{array}{}
U_{d} \left(x\right)=O\bigl((0.5+\sqrt{x+0.25} )^{d} \bigr)
\end{array} $

with fixed x > 0 and d → ∞.
Between the School and Labour Market. Rural Areas and Rural Youth in Poland, Romania and Russia
Authors: Szafraniec Krystyna , Szymborski Paweł , Wasielewski Krzysztof 
Published: February 2018

Abstract
The article analyses the process of rural youth entering the labour market in selected post-communist countries (Poland, Romania and Russia). Based on different types of local (national) and international source data, similarities and differences are discussed between the analysed countries. The article focuses on transition from education to a satisfactory job, nowadays a very complex process that takes up nearly the entire third decade of young people’s life. Although this process is just an external manifestation of general changes occurring in labour markets around the world, the experience of young people from post-communist countries in this area seems to be more traumatic than that of their peers in developed Western countries. Despite significant investments in education, it is difficult to deal with new challenges, particularly for the youth from rural areas. In all the analysed countries, chaotic career paths are typical of this population, and they are often based on temporary jobs, informal forms of employment or self-employment.
Cost Effectiveness of Software Defect Prediction in an Industrial Project
Authors: Hryszko Jaroslaw , Madeyski Lech 
Published: February 2018

AbstractSoftware defect prediction is a promising approach aiming to increase software quality and, as a result, development pace. Unfortunately, the cost effectiveness of software defect prediction in industrial settings is not eagerly shared by the pioneering companies. In particular, this is the first attempt to investigate the cost effectiveness of using the DePress open source software measurement framework (jointly developed by Wroclaw University of Science and Technology, and Capgemini software development company) for defect prediction in commercial software projects. We explore whether defect prediction can positively impact an industrial software development project by generating profits. To meet this goal, we conducted a defect prediction and simulated potential quality assurance costs based on the best possible prediction results when using a default, non-tweaked DePress configuration, as well as the proposed Quality Assurance (QA) strategy. Results of our investigation are optimistic: we estimated that quality assurance costs can be reduced by almost 30% when the proposed approach will be used, while estimated DePress usage Return on Investment (ROI) is fully 73 (7300%), and Benefits Cost Ratio (BCR) is 74. Such promising results, being the outcome of the presented research, have caused the acceptance of continued usage of the DePress-based software defect prediction for actual industrial projects run by Volvo Group.
Wavelets method for solving nonlinear stochastic Itô–Volterra integral equations
Authors: Heydari Mohammad Hossein , Hooshmandasl Mohammad Reza , Cattani Carlo 
Published: February 2018

Abstract
In this paper, a new computational method based on the Chebyshev wavelets (CWs) is proposed for solving nonlinear stochastic Itô–Volterra integral equations. In this way, a new stochastic operational matrix (SOM) for the CWs is obtained. By using these basis functions and their SOM, such problems can be transformed into nonlinear systems of algebraic equations which can be simply solved. Moreover, a new technique for computation of nonlinear terms in such problems is presented. Further error analysis of the proposed method is also investigated and the efficiency of this method is shown on some concrete examples. The obtained results reveal that the proposed method is very accurate and efficient.