bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Strangers from a Different Shore”
Authors: Chen (陈宇晶) Jeannie 
Published: May 2019

Abstract
This exploratory research examines archival representations of Chinese in America in collections dating from before and during the Chinese Exclusion Era (1860–1943), both in mainstream institutional archives/special collections repositories and in smaller community-based archives. Using critical race theory as a methodological framework and an interpretivist case study approach, this research shows a continued lack for transparency surrounding archival description and archival representations within such collections and an uneven distribution of resources across institutions that collect and preserve materials on early Chinese in America. The report identifies the difficulties of balancing evolving terminologies and changing archival descriptive standards/technology and the need for collaboration among bibliographers, catalogers, archivists, historians and activists in creating archival descriptions in collections about the Chinese in America.
The Narrow Protection of Cultural Properties and Historical Monuments in The Rome Statute: Filling the Gap
Authors: Fernández Arribas Gloria 
Published: May 2019

Abstract
In the Al Mahdi case before the International Criminal Court (ICC), the Court raised the possibility of charging the accused with the crime of destroying or seizing the property included in 8(2)(e)(xii) of the ICC statute. A first look would suggest that this crime has different characteristics, or an alternative character, from the crime of attacking protected buildings included in article 8(2)(e)(iv) of which Al Mahdi was finally charged. But upon closer examination, it is also possible to conclude that the crime concerning the destruction or seizure of enemy’s property is supplementary to the criminalisation of the destruction of cultural property. Therefore, a wide and joint interpretation of the crimes could enhance the protection of human cultural legacy through criminal prosecution.
15 Priorities for Wind-Waves Research: An Australian Perspective
Authors: Greenslade Diana , Hemer Mark , Babanin Alex , Lowe Ryan , Turner Ian , Power Hannah , Young Ian , Ierodiaconou Daniel , Hibbert Greg , Williams Greg , Aijaz Saima , Albuquerque João , Allen Stewart , Banner Michael , Branson Paul , Buchan Steve , Burton Andrew , Bye John , Cartwright Nick , Chabchoub Amin , Colberg Frank , Contardo Stephanie , Dufois Francois , Earl-Spurr Craig , Farr David , Goodwin Ian , Gunson Jim , Hansen Jeff , Hanslow David , Harley Mitchell , Hetzel Yasha , Hoeke Ron , Jones Nicole , Kinsela Michael , Liu Qingxiang , Makarynskyy Oleg , Marcollo Hayden , Mazaheri Said , McConochie Jason , Millar Grant , Moltmann Tim , Moodie Neal , Morim Joao , Morison Russel , Orszaghova Jana , Pattiaratchi Charitha , Pomeroy Andrew , Proctor Roger , Provis David , Reef Ruth , Rijnsdorp Dirk , Rutherford Martin , Schulz Eric , Shayer Jake , Splinter Kristen , Steinberg Craig , Strauss Darrell , Stuart Greg , Symonds Graham , Tarbath Karina , Taylor Daniel , Taylor James , Thotagamuwage Darshani , Toffoli Alessandro , Valizadeh Alireza , van Hazel Jonathan , Vieira da Silva Guilherme , Wandres Moritz , Whittaker Colin , Williams David , Winter Gundula , Xu Jiangtao , Zhong Aihong , Zieger Stefan 
Published: May 2019

AbstractThe Australian marine research, industry, and stakeholder community has recently undertaken an extensive collaborative process to identify the highest national priorities for wind-waves research. This was undertaken under the auspices of the Forum for Operational Oceanography Surface Waves Working Group. The main steps in the process were first, soliciting possible research questions from the community via an online survey; second, reviewing the questions at a face-to-face workshop; and third, online ranking of the research questions by individuals. This process resulted in 15 identified priorities, covering research activities and the development of infrastructure. The top five priorities are 1) enhanced and updated nearshore and coastal bathymetry; 2) improved understanding of extreme sea states; 3) maintain and enhance the in situ buoy network; 4) improved data access and sharing; and 5) ensemble and probabilistic wave modeling and forecasting. In this paper, each of the 15 priorities is discussed in detail, providing insight into why each priority is important, and the current state of the art, both nationally and internationally, where relevant. While this process has been driven by Australian needs, it is likely that the results will be relevant to other marine-focused nations.
Dose-dependent neurotoxicity caused by the addition of perineural dexmedetomidine to ropivacaine for continuous femoral nerve block in rabbits
Authors: Wang Hai-Li , Zhang Guang-Ying , Dai Wei-Xin , Shu Li-Pei , Wei Qiu-Feng , Zheng Ruo-Fang , Lin Cheng-Xin 
Published: May 2019

Objective This study was designed to evaluate the neurotoxicity of dexmedetomidine combined with ropivacaine for continuous femoral nerve block in rabbits. Methods Thirty New Zealand rabbits were randomly divided into 5 groups of 6 rabbits each and received a continuous femoral nerve block with saline; 0.25% ropivacaine; or 1, 2, or 3 µg/mL of dexmedetomidine added to 0.25% ropivacaine (Groups A–E, respectively). Sensory and motor function was assessed after the nerve block. The rabbits were anesthetized and killed after 48 hours of a continuous femoral nerve block, and the femoral nerves were removed for light and electron microscopy analyses. Results The behavior scores were highest in Group A at 2 and 6 hours after injection. The scores were higher in Groups B and C than in Groups D and E at these same time points. All groups showed normal pathological tissues in the femoral nerves under optical microscopy. Under electron microscopy, histological abnormalities were observed only in Group E; none of the other groups exhibited pathological abnormalities. Quantitative analysis of the myelin sheath area revealed no significant difference in the axonal area, total area of the myelin sheath, or ratio of the total axonal area to the total area of the myelin sheath in all groups. Conclusion The lowest doses of dexmedetomidine (1 and 2 µg/mL) combined with 0.25% ropivacaine for continuous femoral nerve block resulted in no neurotoxic lesions, but the higher dose (3 µg/mL) resulted in neurotoxic lesions in this rabbit experimental model.
Risk Factors for Myocardial Infarction and Stroke Among Sepsis Survivors: A Competing Risks Analysis
Authors: Hsieh Yueh-Che , Tsou Po-Yang , Wang Yu-Hsun , Chao Christin Chih-Ting , Lee Wan-Chien , Lee Meng-tse Gabriel , Wu Jiunn-Yih , Chang Shy-Shin , Chen Po-Yen , Lee Chien-Chang 
Published: May 2019

Objectives: Predictors for post-sepsis myocardial infarction (MI) and stroke are yet to be identified due to the competing risk of death. Methods: This study included all hospitalized patients with sepsis from National Health Insurance Research Database of Taiwan between 2000 and 2011. The primary outcome was the first occurrence of MI and stroke requiring hospitalization within 180 days following hospital discharge from the index sepsis episode. The association between predictors and post-sepsis MI and stroke were analyzed using cumulative incidence competing risk model that controlled for the competing risk of death. Results: Among 42 316 patients with sepsis, 1012 (2.4%) patients developed MI and stroke within 180 days of hospital discharge. The leading 5 predictors for post-sepsis MI and stroke are prior cerebrovascular diseases (hazard ratio [HR]: 2.02, 95% confidence interval [CI]: 1.74-2.32), intra-abdominal infection (HR: 1.94, 95% CI: 1.71-2.20), previous MI (HR: 1.81, 95% CI: 1.53-2.15), lower respiratory tract infection (HR: 1.62, 95% CI: 1.43-1.85), and septic encephalopathy (HR: 1.61, 95% CI: 1.26-2.06). Conclusions: Baseline comorbidities and sources of infection were associated with an increased risk of post-sepsis MI and stroke. The identified risk factors may help physicians select a group of patients with sepsis who may benefit from preventive measures, antiplatelet treatment, and other preventive measures for post-sepsis MI and stroke.
Amphetamine-type-substance-related presentations to the Emergency Department Mental Health Team of a local health district in Australia
Authors: Chivaurah Bernard M , Lienert David , Coates Dominiek 
Published: May 2019

Objectives: To identify the prevalence and profile of amphetamine-type-substance-related presentations to the Emergency Department Mental Health Team of a local health district in Australia. Methods: Data was collected from medical records of all amphetamine-type-substance presentations to the Emergency Department Mental Health Team over a 1-year period, between 1 January 2015 and 31 December 2015. Results: Of all presentations referred to the Emergency Department Mental Health Team, 0.15% ( N = 189) were amphetamine-type-substance related. Of these, the majority were male, the average age was 32, 19.0% engaged in intravenous drug use, some were aggressive and 15.9% required tranquilisation. The most common presenting issues were psychosis and suicidal threats, intent and behaviour (including intentional overdose). Multiple comorbid conditions were identified. On discharge, 34.4% were admitted into a psychiatric hospital and 32.8% were referred to Community Mental health teams. Conclusions: Amphetamine-type-substance users suffer from multiple comorbidities and pose a significant burden on emergency services.
Mindfulness-based intervention to reduce burnout and psychological distress, and improve wellbeing in psychiatry trainees: a pilot study
Authors: Kang Matthew , Selzer Rob , Gibbs Harry , Bourke Katie , Hudaib Abdul-Rahman , Gibbs Jo 
Published: May 2019

Background: Healthcare professionals including psychiatry trainees experience high amounts of occupational stress. This pilot study aims to assess the impacts and feasibility of a mindfulness-based intervention program as an occupational intervention in a metropolitan hospital. Method: Psychiatry trainees participated in an mindfulness-based intervention training program consisting of 1-h weekly sessions over 8 weeks. Levels of psychological distress and mindfulness were measured pre and post-intervention. Qualitative data through an open-ended feedback survey were also collected. Results There was an improved level of mindfulness and a decreased level of burnout among trainees post-intervention. Advantages of the program included having a compassionate facilitator and the program being tailored to healthcare staff. Limiting factors included time restraints and clinical responsibilities. Conclusion: Psychiatry trainees can benefit from an occupational MBI program. This can positively impact their health as well as improve their work performance. A number of factors important for implementation of a mindfulness-based intervention program were also identified.
Evaluation of the role of pharmacy technicians in reviewing the eligibility for Oncotype DX genomic test and the impact of the test on treatment plans in breast cancer patients
Authors: Cheng Vian , Markarian Adeline , de Lemos Mario L , Schaff Kimberly 
Published: May 2019

Purpose/Objectives The Oncotype DX genomic test is a treatment decision-making tool. Test results are presented as recurrence scores which are used to help decide between adjuvant hormonal therapy (low recurrence score) or chemotherapy (high recurrence score). Since 2014, the Oncotype DX test has been funded at the cancer treatment centres in our province for patients with early breast cancer. Eligibility criteria for funding include patient and tumour characteristics. Pharmacy technicians were assigned to review and approve requests based on the eligibility criteria and with access to consultation to an oncology pharmacist and a medical oncologist. We assessed the clinical role of pharmacy technicians in this review process and the impact of recurrence score on treatment decisions. Methods This was a retrospective, multi-centre study to evaluate the Oncotype DX test eligibility review process from June 2014 to May 2015. The main objectives were to assess (1) the discrepancy rate of approval by the pharmacy technicians in this review process and (2) the concordance rate between the recurrence score from the Oncotype DX test and the adjuvant treatment given. Results Four hundred and forty requests for Oncotype DX test were received during the study period. A total of 90.8% of requests were approved and 9.2% were denied. The discrepancy rate of approval by pharmacy technicians was 1.1%. The average review time was 13.8 min, with the reviewing pharmacist and oncologist consulted in 5.5 and 15.2% of the requests, respectively. The concordance rate between the recurrence score and given treatment was 96%. Discussion The discrepancy rate of our pharmacy technicians appears to be similar to that reported with other expanded technician roles in literature, suggesting that the current task and other similar clinical tasks can be reliably delegated to technicians. The concordance rate of the recurrence score and given treatment in our study was higher than what has been reported in literature, suggesting that most of our patients were treated in accordance to recurrence score-based recommendations. Conclusion Pharmacy technicians were able to expand their clinical role by accurately reviewing the Oncotype DX test requests with a low discrepancy rate. The Oncotype DX test results appeared to successfully guide the adjuvant treatment given to patients in accordance to recurrence score-based recommendations.
Antibody response to feline herpesvirus-1 vaccination in healthy adult cats
Authors: Bergmann Michèle , Speck Stephanie , Rieger Anna , Truyen Uwe , Hartmann Katrin 
Published: May 2019

Objectives Vaccination against feline herpesvirus-1 (FHV-1) is recommended for all cats. However, it is unknown how adult healthy cats with different pre-vaccination antibodies respond to FHV-1 vaccination in the field. The aim of the study was to determine the prevalence of neutralising antibodies against FHV-1 in healthy adult cats and the response to FHV-1 vaccination within 28 days of vaccination. Methods One hundred and ten cats (⩾1 year of age) that had not received a vaccination within the past 12 months were vaccinated with a combined FHV-1 vaccine. Antibodies against FHV-1 were determined before vaccination (day 0), on day 7 and day 28 by serum neutralisation test. Uni- and multivariate statistical analyses were used to determine factors associated with the presence of pre-vaccination antibodies and response to vaccination. Results Pre-vaccination neutralising antibody titres (⩾10) were present in 40.9% of cats (45/110; 95% confidence interval [CI] 32.2–50.3); titres were generally low (range 10–640). Antibody response to vaccination (⩾four-fold titre increase) was observed in 8.3% (9/109; 95% CI 4.2–15.1). Cats ⩾2 years of age were more likely to have pre-vaccination neutralising antibodies than cats aged between 1 and 2 years (odds ratio [OR] 24.619; P = 0.005). Cats from breeders were more likely to have pre-vaccination neutralising antibodies than privately owned cats (OR 7.070; P = 0.007). Domestic shorthair cats were more likely to have an at least four-fold titre increase vs purebred cats (OR 11.22; P = 0.027). Conclusions and relevance Many cats have no detectable neutralising antibodies against FHV-1 despite previous vaccinations and fail to develop a ⩾four-fold titre increase after vaccination. This is likely because older cats and cats with a higher FHV-1 exposure risk are more likely to get infected with FHV-1 and thus to have FHV-1 neutralizing antibodies. Purebred cats more often fail to develop a ⩾four-fold titre increase after vaccination.
Tuberculosis due to Mycobacterium bovis in pet cats associated with feeding a commercial raw food diet
Authors: O’Halloran Conor , Ioannidi Olympia , Reed Nicki , Murtagh Kevin , Dettemering Eili , Van Poucke Stefaan , Gale John , Vickers Julie , Burr Paul , Gascoyne-Binzi Deborah , Howe Raymond , Dobromylskyj Melanie , Mitchell Jordan , Hope Jayne , Gunn-Moore Danièlle 
Published: May 2019

Objectives Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex, can infect cats and has proven zoonotic risks for owners. Infected cats typically present with a history of outdoor lifestyle and hunting behaviour, and cutaneous granulomas are most commonly observed. The aim of this study is to describe an outbreak of tuberculous disease commencing with six young cats, living exclusively indoors in five different households across England, being presented to separate veterinarians across the UK with a variety of clinical signs. Methods Investigations into the pyogranulomatous lesions, lymphadenopathy and/or pulmonary disease of these cases consistently identified infection with M bovis. Infection was confirmed by PCR, where possible, or was indicated with a positive interferon-gamma release assay (IGRA), where material for PCR was unavailable. In-contact, cohabiting cats were screened by IGRA and follow-up testing was undertaken/advised where results were positive. A lifestyle investigation was undertaken to identify the source of infection. Results Six clinically sick cats and seven in-contact cats were identified with evidence of M bovis infection. Five clinical cases were either too sick to treat or deteriorated despite therapy, giving a mortality rate of 83%. Lifestyle investigations revealed the common factors between clusters to be that affected cats had mycobacterial infections speciated to M bovis, were exclusively indoor cats and were fed a commercially available raw food product produced by a single manufacturer. The Food Standards Agency, Animal & Plant Health Agency, Public Health England and the food manufacturer concerned have been notified/informed. Other possible sources of exposure for these cats to M bovis were explored and were excluded, including wildlife contact, access to raw milk, the presence of rodent populations inside the buildings in which the cats lived and exposure to known infectious humans. Conclusions and relevance Upon investigations, our results provide compelling, if circumstantial, evidence of an association between the commercial raw diet of these cats and their M bovis infections.
‘Social work is not just a job’: The qualities of social workers from the perspective of service users
Authors: Kam Ping Kwong 
Published: May 2019

Summary The social work profession emphasises the development of the personal qualities of social workers in addition to requiring them to possess the necessary professional values, knowledge, theories and practice skills. Until now, we have tended to rely on the perspective of social work professional bodies, educators and employers to assess the personal qualities of social workers. We have seldom inquired about the views of service users on the qualities of social workers, thus disregarding their perspective. This article focuses on identifying the important qualities of social workers from the perspective of service users. Findings This paper reports on qualitative research on the personal qualities of social workers that service users value in Hong Kong. It draws on a diverse range of service users with direct experiences of the services provided by social workers. A total of 47 service users from 7 core social welfare service settings and 32 service units participated in an in-depth qualitative interview. Six significant personal qualities of social workers from the service users’ perspective are identified and discussed. Applications The findings have several implications for examining directions for development of the social work profession, the relationship between service users and social workers, effective ways to develop the personal qualities of students in social work education and ways to resolve the dilemma between service users’ expectations and the existing mode of social work service delivery. Issues of particular relevance to Hong Kong are highlighted in discussing these implications.
Efficacy of ertugliflozin in monotherapy or combination therapy in patients with type 2 diabetes: A pooled analysis of placebo-controlled studies
Authors: Liu Jie , Tarasenko Lisa , Terra Steven G , Huyck Susan , Wu Larry , Pong Annpey , Calle Roberto A , Gallo Silvina , Darekar Amanda , Mancuso James P 
Published: May 2019

Background: This pooled analysis assessed the efficacy of ertugliflozin versus placebo as monotherapy or with other antihyperglycaemic agents across patient subgroups defined by demographic and disease characteristics. Methods: Data from three phase III randomised, placebo-controlled, double-blind studies (NCT01958671, NCT02033889 and NCT02036515) with similar designs and populations were pooled ( N = 1544). Results: At Week 26, placebo-adjusted least squares mean changes from baseline in glycated haemoglobin with ertugliflozin 5 and 15 mg were −0.8% (95% confidence interval: −0.9, −0.7) and −0.9% (–1.0, −0.8), respectively. Reductions were consistent across subgroups. Placebo-adjusted least squares mean changes in body weight were −1.8 kg (−2.2, −1.4) for both ertugliflozin doses; for systolic blood pressure, these were −3.4 mmHg (−4.8, −2.0) and −3.5 mmHg (−4.9, −2.0) for ertugliflozin 5 and 15 mg, respectively. Higher proportions of patients receiving ertugliflozin had glycated haemoglobin <7.0%, weight loss ⩾5% and systolic blood pressure <130 mmHg versus placebo. Ertugliflozin and placebo safety profiles were similar, including incidences of hypoglycaemia, urinary tract infection and hypovolaemia. Genital mycotic infection and adverse events related to osmotic diuresis were more common with ertugliflozin. Conclusion: Ertugliflozin demonstrated efficacy as monotherapy or with other antihyperglycaemic agents in patients with different demographic and disease characteristics and was generally well tolerated.
FAM84B promotes prostate tumorigenesis through a network alteration
Authors: Jiang Yanzhi , Lin Xiaozeng , Kapoor Anil , He Lizhi , Wei Fengxiang , Gu Yan , Mei Wenjuan , Zhao Kuncheng , Yang Huixiang , Tang Damu 
Published: May 2019

Background: The aim of this study was to investigate the contributions of FAM84B in prostate tumorigenesis and progression. Methods: A FAM84B mutant with deletion of its HRASLS domain (ΔHRASLS) was constructed. DU145 prostate cancer (PC) cells stably expressing an empty vector (EV), FAM84B, or FAM84B (ΔHRASLS) were produced. These lines were examined for proliferation, invasion, and growth in soft agar in vitro. DU145 EV and FAM84B cells were investigated for tumor growth and lung metastasis in NOD/SCID mice. The transcriptome of DU145 EV xenografts ( n = 2) and DU145 FAM84B tumors ( n = 2) was determined using RNA sequencing, and analyzed for pathway alterations. The FAM84B-affected network was evaluated for an association with PC recurrence. Results: FAM84B but not FAM84B (ΔHRASLS) increased DU145 cell invasion and growth in soft agar. Co-immunoprecipitation and co-localization analyses revealed an interaction between FAM84B and FAM84B (ΔHRASLS), suggesting an intramolecular association among FAM84B molecules. FAM84B significantly enhanced DU145 cell-derived xenografts and lung metastasis. In comparison with DU145 EV cell-produced tumors, those generated by DU145 FAM84B cells showed a large number of differentially expressed genes (DEGs; n = 4976). A total of 51 pathways were enriched in these DEGs, which function in the Golgi-to-endoplasmic reticulum processes, cell cycle checkpoints, mitochondrial events, and protein translation. A novel 27-gene signature (SigFAM) was derived from these DEGs; SigFAM robustly stratifies PC recurrence in two large PC populations ( n = 490, p = 0; n = 140, p = 4e−11), and remains an independent risk factor of PC recurrence after adjusting for age at diagnosis, Gleason scores, surgical margin, and tumor stages. Conclusions: FAM84B promotes prostate tumorigenesis through a complex network that predicts PC recurrence.