bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plerixafor for patients who fail cytokine-or chemotherapy-based stem cell mobilization: Results of a prospective study by the Polish Lymphoma Research Group (PLRG)
Authors: Giebel Sebastian , Oborska Sylwia , Romejko-Jarosinska Joanna , Dybko Jarosław , Mańko Joanna , Sawczuk-Chabin Joanna , Szymańska Agata , Legieć Wojciech , Czyż Anna , Maruszak Magdalena , Saduś-Wojciechowska Maria , Drozd-Sokołowska Joanna , Steckiewicz Paweł , Ejduk Anna , Paszkiewicz-Kozik Ewa , Ogórka Tomasz , Osowiecki Michał , Targoński Łukasz , Taszner Michał 
Published: April 2019

AbstractAutologous hematopoietic stem cell transplantation (autoHSCT) requires collection of sufficient number of hematopoietic stem cells. The goal of this study was to evaluate efficacy of plerixafor used in patients with lymphoid malignancies failing conventional stem cell mobilization.This was a prospective, non-interventional study. All consecutive patients (n = 109) treated with plerixafor in 11 centers were reported. The drug was used either in case of previous mobilization failure (n = 67) or interventionally, in case of insufficient CD34+ cell output during current mobilization (n = 42). Successful mobilization was defined as resulting in collection of ≥ 2 × 106 CD34+ cells/kg for single autoHSCT or ≥ 4 × 106 CD34+ cells/kg for double procedure.The overall rate of successful mobilization was 55% (55% for single and 56% for double autoHSCT). The median total number of collected CD34+ cells/kg was 2.4 (range, 0-11.5) for patients intended for a single transplantation while 4.0 (0.6-16.9) for double procedure. The number of circulating CD34+ cells increased after the use of plerixafor regardless of baseline values. The median fold increase was 3.3 (0.3-155). Data from this observational study confirm high efficacy of plerixafor used in routine clinical practice as salvage for patients with lymphoid malignancies failing conventional stem cell mobilization.
Progress of research on the immune tolerance of chronic HBV infection
Authors: Li Xuemei , Li Xiaoxia 
Published: April 2019

Abstract
Immune tolerance is a specific lack or negative response of T and B lymphocytes to antigen. According to different formation periods, immune tolerance can be divided into central and peripheral tolerances. The immune tolerance of the body to hepatitis B virus (HBV) after infection is the main cause of chronic HBV infection. In this paper, the functional defects of hepatitis B virus e antigen and dendritic cells, hyporesponsiveness of cytotoxic T lymphocyte, variation of helper T lymphocytes and cytokines, HBV genotype and genome, and the role of host gene polymorphism in the formation of immune tolerance in chronic HBV infection and its related research progress are introduced briefly.
Pengaruh Financial Leverage, Likuiditas, Pertumbuhan Asset, dan Ukuran Perusahaan terhadap Beta Saham Pada Perusahaan Manufaktur Yang Terdaftar di Bursa Efek Indonesia
Authors: Handayani Desi Wury 
Published: April 2019

The purpose of this study is to investigate the influence of financial leverage, liquidity, asset growth, size on the beta stock in manufacturing companies in Indonesia Stock Exchange. The sample in this study is manufacturing companies listed in Indonesia Stock Exchange during the 5 periods (2008-2012). Total samples are 58 companies. The sample selection is done by using the method of stratified random sampling. The multiple linear regression analysis was used to test the hypothesis.This research found that asset growth has significant effect on systematic risk, while variable financial leverage, liquidity, sizedid not have significant effect on systematic risk. The purpose of this study is to investigate the influence of financial leverage, liquidity, asset growth, sizeon the beta stock in manufacturing companies in Indonesia Stock Exchange. The sample in this study is manufacturing companies listed in Indonesia Stock Exchange during the 5 periods (2008-2012). Total samples are 58 companies. The sample selection is done by using the method of stratified random sampling. The multiple linear regression analysis was used to test the hypothesis.This research found that asset growth has significant effect on systematic risk, while variable financial leverage, liquidity, sizedid not have significant effect on systematic risk.
INSTITUTIONAL INVESTORS, LEVERAGE, DAN PROFIBILITAS TERHADAP FLEKSIBILITAS AKUNTANSI PERUSAHAAN
Authors: Islahuddin Islahuddin , Akramadina Akramadina 
Published: April 2019

Abstract The purpose of this study is to examine and analyze the influence of institutional investors, leverage, and profitability for firms accounting flexibility. The population of this study is manufacturing companies listed in the Indonesia Stock Exchange between 2009 and 2011. This study is a hypothesis testing research that involve 51 firms. The data is obtained from audited financial reporting period between 2009 and 2011. This study found that institutional investors, leverage and profitability simultaneously have influence for firm accounting flexibility, institutional investors has positive influence for firm accounting flexibility, leverage has negative influence for firm accounting flexibility and profitability has negative influence for firms accounting flexibility. Keywords: Institutional investors, leverage, profitability, and firms accounting flexibility
THE ASSESMENT EFFECTIVENESS OF ANTIARRHYTHMIC THERAPY WITH AMIODARONE OF ATRIAL FIBRILLATION PAROXYSMS AT THE PREHOSPITAL STAGE IN DIFFERENT PATIENTS AGE GROUPS
Authors: Truhanova I. G. , Zinatullina D. S. , Polyakov I. A. , Sadreeva S. H. 
Published: April 2019

A retrospective content analysis of 210 emergency medical call cards with paroxysms of atrial fibrillation up to 48 hours was carried out in order to analyze and improve the algorithm of prehospital therapy of emergency arrhythmias based on the study of the peculiarities of amiodarone action in elderly and young patients in emergency care.
FEATURES AND ORIENTATIONS OF TRANSPORT OF OXYGEN AT PATIENTS WITH HEMORRHAGIC SHOCK
Authors: Girsh A. O. , Stukanov M. M. , Macsimishin S. V. , Malyuk A. I. , Stepanov S. S. , Korzuk M. S. 
Published: April 2019

In work are presented results of the research executed at 285 patients with traumatic shock of varying severity at which defined development of the acute respiratory distress syndrome (ARDS). It is taped that at patients with traumatic shock of the I degree ARDS phenomena don’t become perceptible. At patients with traumatic shock of the II degree emergence of ARDS in 17,8%. At patients with traumatic shock of the III degree emergence of ARDS in 100%.
The role of the transnational ultra-processed food industry in the pandemic of obesity and its associated diseases: problems and solutions
Authors: Monteiro Carlos A. , Cannon Geoffrey John 
Published: April 2019

Policies to control and prevent the pandemic of obesity and related conditions and diseases have failed. This is because the efficient causes of the pandemic have not yet been agreed. We state here that its outstanding immediate cause is the increased and rapidly increasing consumption of ultra-processed foods, which displace unprocessed or minimally processed foods and freshly prepared dishes and meals, most conspicuously now in middle- and lower-income countries.

The underlying cause of this is the phenomenal rise since the 1980s of the transnational corporations whose huge profits depend on the use of cheap ingredients and arrays of additives made into ultra-processed food. The scale and power of the transnationals, which tend towards oligopoly, and their penetration of middle and lower-income countries, have been accelerated by global political and economic agreements that have deregulated trade and allowed capital flow that opens countries to penetration by foreign businesses.

Food is essential for life and health, but there is no need to consume ultra-processed foods. In this sense, they are similar to tobacco products. The same statutory policies and programmes that are applied to smoking should be adapted to limit and reduce consumption of ultra-processed foods. Revenue from taxation should be used to protect local food producers and retailers, to promote healthy and sustainable diets, and to ensure food security for vulnerable populations. Overall, a Framework Convention on Food Systems, promulgated by the relevant United Nations agencies as agreed by UN member states, supported by professional and civil society organisations and social movements, is needed. This will be designed to create healthy food systems and supplies and thus healthy diets that also are beneficial socially, culturally, economically and environmentally.
Morphosyntaxe et sémantique de quelques locutions contenant le mot « tête » dans les canadianismes
Authors: Gauthier Valérie , Hien Amélie , Reguigi Ali 
Published: April 2019

Bien qu’une intercompréhension entre les locuteurs du français à travers le monde soit possible grâce aux nombreuses conventions prescrites, l’efficacité de leur communication peut toutefois être compromise à cause de la présence de mots et d’expressions propres à un pays ou à une région. En effet, le français est susceptible de variations synchroniques et diachroniques, étant donné les variations culturelles, sociales, économiques et politiques à l’intérieur d’un même pays et entre les pays ou les régions partageant cette langue. Ces mots et locutions, qui peuvent faire partie du vocabulaire de certains locuteurs, réfèrent alors à des réalités spécifiques de leurs pays ou de leurs régions. En outre, ces expressions ont souvent une telle opacité sémantique que les locuteurs étrangers à celles-ci risquent d’être déroutés et ne seront pas en mesure d’en comprendre le sens (Klett, 2013, p. 60). À titre d’exemple, dans une situation où un locuteur francophone de la Belgique communique avec un locuteur francophone du Canada, il est possible qu’il y ait une incompréhension des expressions utilisées de part et d’autre.
De même, cette incompréhension peut s’instaurer entre locuteurs d’un même pays. Cela suggère que le vocabulaire de ces locuteurs diffère par des facteurs individuels, c’està-dire des facteurs sociolinguistiques, qui ont un effet sur leur usage et leur compréhension des expressions. C’est sur cette incompréhension que nous nous penchons dans cette étude.
Étant donné la panoplie d’expressions existantes, nous avons restreint notre champ de recherche en ne nous intéressant qu’à quelques locutions anatomiques1 contenant le mot « tête » dans les canadianismes, telles que « être une tête carrée » et « avoir des yeux tout le tour de la tête ».
ELEŞTİRİ, SEKÜLERİZM VE KÜLTÜR
Authors: KAYINTU Ahmet 
Published: April 2019

Bu çalışmada sekülerizm
konusu bağlamında sekülerizm ile kültür eleştirisi, edebiyat ve din ilişkisi
çok disiplinli bir yaklaşım içinde sorgulanmaktadır. Seküler eleştiri, kapsamlı
bir örnek oluşturması açısından Edward Said'in görüşleri esas alınarak
tartışılmıştır. Said’e göre sekülerizmin anlamı, dinî dayanışma, ulusal
hareketler, profesyonellik ve “organik” ya da sınıfsal entellektüellik
uygulamalarına karşı olan muhalif bir eleştirel pratiktir. Onun ifadelerini ve genel yaklaşımlarını
ifade etmek gerekirse, metinlerin dünyevi olduğu, bir dereceye kadar olaylardan
oluştuğu, inkâr ettikleri zaman bile, yine de sosyal dünyanın, insan hayatının
ve elbette içinde bulundukları tarihi anların bir parçası olduklarını ve
yorumlandıklarını ifade etmektedir. Günümüzde,
sekülerizmin dinden tamamen ayrı olmadığı ve dinin zıddı olmadığı düşüncesi gittikçe
daha fazla yayılıyor. Buna göre tarih, her ne kadar insanların eseri ise de, Tanrıya
bağlı, ona inanan, onu seven ve ondan korkan insanların eseridir. İnsanların
maddi eserlerinin ardındaki motivasyonun kaynağı olan din göz ardı edilerek bir
sonuca varmak olası değildir. Ayrıca kültür ve edebiyatın seküler ve dini
boyutları da makalede ele alınan konular arasındadır. Aynı şekilde, sekülerizmin
salt bir dini ve dünyevi ayrımından ibaret olmadığı, sekülerizmin normatif bir
karakterde olduğu tartışmasına yer verilmektedir.
The Relation between the Eruption of the Deciduous Teeth and the Development and Growth of the Child
Authors: Banoosh Sulafa Khair Al-Deen 
Published: April 2019

This article aimed to find any relation between the eruption of the deciduous teeth and the development and growth of the child. This study included 77 children, aged between (1-2) years old all examined orally for any deciduous teeth eruption and record any delayed case, the parents of child answered 30 questions about the children's development.
The results of this study shown that there were no significant differences (P<0.05) between the teething (eruption of teeth) and the five developmental domains. Delayed teething was seen more among those with normal gross motor, and among those with delayed fine motor (statistically significant at 0.5 level). No relation between the eruption of the teeth and the development of the child and the teething time might be affected by local causes more than the systemic cause; these results need more researches and studies to prove these facts.
Effect of Addition of Different Levels of Commercial Baker's Yeast to Concentrate Diet of Multiparous Mid-Lactation Holstein Friesian Cows on Rumen Fermentation Characteristics
Authors: Mohammed Waleed Ahmed , Saeed Ali Ameen 
Published: April 2019

This study was conducted in Grand station of Diwania/ Taj Al-Nahrain company- Al-Qadisiya Province for 84 days to investigate the effect of level of addition of commercial baker's yeast Saccharomyces cerevisiae,0, 15 and 30 g/cow/day to concentrate diet on rumen fermentation characteristics in German Holstein Friesian lactating cows. Nine multiparous Holstein cows in their mid-lactation were used. Daily feeding program applied in that station included offering 1 kg of concentrate diet per 3-4 kg milk produced divided into morning and evening meals, 10 kg of green forage, 10 kg whole plant corn silage and free choice of rice straw. Silage was characterized with accepted quality and fermentation parameters, values of pH, concentrations of ammonia nitrogen (NH3-N) and total volatile fatty acids (TVFA) were, 3.5, 0.98% of total nitrogen and 2.55 mM/DM respectively. Results revealed that addition of yeast at level of 15 and 30 g/cow/day reduced (P<0.01) concentration of NH3-N from 18.14 to 13.92 and 14.21 mg/100 ml respectively. Significant (P<0.01) increase in concentration of TVFA from 7.32 to 9.39 mM /100 ml was also observed due to addition of yeast at level of 15 g/cow/day. However, ruminal pH values were not affected by addition of yeast
GLOMERULAR DISEASES IN MADINA REGION;
Authors: Manzoor Adil , Bhatt Imtiaz , Javed Rehan 
Published: April 2019

Objectives: The study is designed to get useful information and epidemiological data for clinical practice and investigations regarding glomerular disease frequencies in Madina region. Study Design & Setting: Single-center retrospective study at King Fahd Hospital Madina. Period: 01 year (March 2016- March 2017). Methods: All native renal biopsies were studied for the period of 1 year (March 2016- March 2017). Only glomerular disease patterns were analyzed. The diagnosis of each case was based on histological, immunopathological and clinical features. Results: A total of 44 biopsies were Included. Primary glomerular diseases in 52.27% of all biopsies studied. The most common primary disease was Membranous Nephropathy which accounts for 20.45%. Focal and Segmental Glomerulosclerosis (FSGS) (9%), Minimal change disease (4.54%), C3 glomerulopathy (4.54%), IGA Nephropathy (4.54%), Non-IgA Mesangial Proliferative GN(2.27%), Crescentic Glomerulonephritis (GN) (2.27%), Post lnfectlous GN(2.27%), Thin Basement Membrane Nephropathy(2.27%) as primary GN. Secondary glomerular diseases in 47.73%. Lupus Nephritis corresponded to 34.09% of the entire series. Conclusions: FSGS has been the most frequent type of glomerulopathy in Saudi Arabian population according to previously available data from local studies but in our study the cases of Membranous Nephropathy were high .Lupus Nephritis remain above the list as a cause of secondary glomerular disease. The reasons for these findings are unclear but this information is an important contribution towards understanding the prevalence of renal diseases In Saudi Arabia.
METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;
Authors: Khawaja Aneela , Arshad Faiqa , Jamil Rabiya 
Published: April 2019

Introduction: The versatility of Staphylococcus aureus has been transformed as “Methicillin resistant Staphylococcus aureus”. The most challenging are the disastrous virulence patterns being expressed due to the selection pressure of antibiotics. For assessing the prevalence of methicillin resistant Staphylococcus aureus; screening by cefoxitin disc (30µg) diffusion method is still a realistic approach among conventional phenotypic methods, being applied in most of the laboratories. This reliable and feasible technique contributes significantly for MRSA detection. This study has been designed to evaluate the prevalence and identify the sensitivity pattern of methicillin resistant Staphylococcus aureus isolates from different clinical specimens in a tertiary care hospital. Study Design: Descriptive study. Setting: Pathology Department, Microbiology Laboratory, PGMI. Period: January 2015 to December 2015. Materials & Methods: A total 713 clinical isolates of Staphylococcus aureus were processed. Identification and confirmation of Staphylococcus aureus was done by colony morphology on blood agar, gram stain, catalase, coagulase and DNA-ase tests. Screening for methicillin resistance was done using cefoxitin disc (30mg, OXOID); while different antibiotic discs were used to assess the sensitivity profile by Modified Kirby-Bauer Disc Diffusion method according to CLSI guidelines (2016). Results: Out of 713 Staphylococcus aureus isolates, 92 (12.90%) isolates were labelled as methicillin resistant by cefoxitin disc diffusion test. Out of 92 MRSA isolates, 57 (14.65%) were recovered from male patients and 35 (10.80%) from female patients. While, 60 (65.22%) MRSA isolates showed hemolysis on blood agar. Among 92 MRSA isolates, 41 (44.57%) were recovered from pus specimen. Resistance to trimethoprim/sulfamethoxazole was highest (65.22%) after penicillin (100%); while all the MRSA isolates were 100% sensitive to both vancomycin and linezolid. Conclusion: The prevalence of MRSA in hospital care settings is of great clinical concern. To combat this public health threat effectively, continuous surveillance of health-care associated infections, along with local antibiotic sensitivity pattern of MRSA; as well as formulation of a definite antibiotic policy is required.
FACTORS ASSOCIATED WITH HIGH FERTILITY IN”BHAKKAR GABOOL GOTH”: CASE STUDY
Authors: Khattak Sanam wagma 
Published: April 2019

Pakistan is holding only 0.67 percent of the whole world’s area but has 2 percent of world population. In 1951 it ranked at 14th position in the world’s populous countries. In 2015-16 its population jumped to 195.4 million approximately five times higher. With this high population it has become the 6th most high populated country in the world. Human fertility is not a personal decision but it is a mixture of factors, and the factors differ among places, according to specific conditions of particular areas & cultures. The aim of current research is to determine major factors that encourage high child ever born in urban slum area of Karachi” Bhakkar Gabool Goth” questionnaire was filled up from 100 ever married house hold women through simple sampling method based on formation on socio economic determinants like respondent’s age and their husband’s income/education level/place of childhood residence, etc etc. The analysis were based on descriptive analysis through percentages and number distribution of respondents .The median or average number of kids were greater than 5 and out of 23 variables discussed in questionnaire , only 14 variables show significant relation with fertility level which were respondent current age, education status of respondent/ her husband, work status of respondent and her husband, types of work, age at first marriage/first birth, infant/child mortality, contraception, sex preferences and willingness of respondent/ her husband to have more kids. more and more family health clinics should be established particularly in slum areas, female education should be increased to encourage delayed marriages and contraception use should also be enhanced through media or health visitors.
FOTO PREWEDDING DALAM PRESPEKTIF SANTRI PONDOK PESANTREN AL-ISHLAH BANDAR KIDUL MOJOROTO KOTA KEDIRI
Authors: Hermawan Andik , Ropingi Ropingi 
Published: April 2019

Fotografi menjadi sebuah ladang bisnis baik bagi fotografer pemula maupun fotografer profesional. Sekarang ini foto prewedding sudah menjadi budaya baru di tengah-tengah masyarakat modern, yakni foto yang dilakukan sebelum pernikahan. Tidak terkecuali umat muslim juga melaksanakan foto prewedding yang mana hukum dari foto prewedding tersebut adalah haram. Penelitian ini bertujuan untuk mengetahui bagaimana pemaknaan santri Pondok Pesantren Al-Ishlah Bandar Kidul Mojoroto Kota Kediri terkait tentang foto prewedding tersebut. Mulai dari tahap eksternalisasi di mana santri beradaptasi dengan budaya baru ini. Kemudian tahap objektivasi, memahami bagaimana dan seperti apa foto pre wedding. Yang terakhir tahap internalisasi, yakni santri memberi pemaknaan atau penafsiran terhadap foto pre wedding.
Dalam penelitian ini penulis menggunakan pendekatan kualitatif dengan menggunakan tiga metode pengumpulan data yaitu observasi, yang mana penulis menjadi observasi partisipan, wawancara mendalam (indept interview), informan dari penelitian ini adalah santri Pondok Pesantren Al-Ishlah yang berjumlah 20 orang, dan selanjutnya dokumentasi. Untuk menganalisis data penulis menggunakan teknik Analisis Interaktif Miles dan Huberman dengan membuat gambaran yang sistematis, faktual dan analisisnya dilakukan melalui tiga jalur reduksi data, penyajian data (data display), dan penarikan kesimpulan.
Penelitian ini mendapatkan hasil bahwa santri Pondok Pesantren Al-Ishlah Bandarkidul, Mojoroto, Kota Kediri memberi penafsiran atau pemaknaan terhadap foto prewedding dengan beberapa tahap seperti yang dikemukakan oleh Peter L. Berger. Pertama tahap eksternalisasi di mana santri membuka diri dan beradaptasi dengan budaya baru yang ada di masyarakat yakni foto pre wedding. Kemudian tahap objektivasi, santri berusaha memahami bagaimana dan seperti apa foto pre wedding tersebut. Yang terakhir tahap internalisasi, yakni santri memberi pemaknaan atau penafsiran terkait foto pre wedding yang menjamur di masyarakat. Bahwa hukum foto pre wedding menurut santri adalah haram, apabila dalam pembuatan dan hasil foto terdapat adegan atau pose yang melanggar syariat. Dan boleh melakukan foto pre wedding, apabila dalam pembuatan dan hasil foto pre wedding tidak menyalahi syariat dan norma agama.

Kata kunci: Konstruksi, Santri, Foto Prewedding.
НАДАННЯ ПІДВИЩЕНОЇ ЗНОСОСТІЙКОСТІ ТКАНИНАМ ДЛЯ ЗАХИСНОГО ОДЯГУ
Authors: Кулікова І. О. , Міщенко Г. В. , Міщенко О. В. , Венгер О. О. , Попович Т. А. 
Published: April 2019

The purpose of the work is to increase the wear resistance of textile materials by forming composite polymer films on their surfaces. Methodology. The problem was solved by the use of a mixture of polymers and due to their ability to formulate composite polymer systems that combine the properties of individual polymers and exhibit new ones. One of them was used in the form of aqueous dispersion of the finished polymer of urethane type, and the second one was synthesized from pre-condensates of thermosetting resins (PTSR) in the process of finishing, namely, at the stage of heat treatment of the fabric after impregnation and drying, by providing conditions for the course of the condensation reaction.