bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-modality molecular imaging characteristics of dementia with Lewy bodies
Authors: Gao Zhong-Bao , Wang Wei , Zhao Xing-Li , Chen Tong , Fu Li-Ping , Xu Bai-Xuan , Wang Zhen-Fu 
Published: April 2018

Objective Dementia with Lewy bodies (DLB) is a common type of neurodegenerative dementia. Molecular neuroimaging using dopamine transporter (DaT), Pittsburgh compound B (PIB), and fluorodeoxyglucose (FDG) positron emission tomography (PET) has advantages in detecting dopaminergic neuron loss, abnormal amyloid β-protein deposition, and glucose metabolism changes in patients with neurodegenerative disorders. However, the multi-modality molecular imaging features of patients with DLB have rarely been reported. Methods Five patients with a probable diagnosis of DLB were enrolled. PET/magnetic resonance imaging was performed with three tracers: 11C-β-CFT, 11C-PIB, and 18F-FDG. Clinical and imaging characteristics were analyzed. Results All patients with DLB showed reduced uptake in the bilateral putamen on DaT PET, increased uptake throughout the cerebral cortex on PIB PET, and intact metabolism of the posterior cingulate gyrus on FDG PET. Conclusion Multimodal molecular imaging is helpful for early diagnosis of DLB. Studies with larger sample sizes are needed to confirm the molecular imaging differences between DLB and Alzheimer’s disease and Parkinson’s disease dementia.
Clinical outcomes with a diffractive trifocal intraocular lens
Authors: Alió Jorge L , Plaza-Puche Ana B , Alió del Barrio Jorge L , Amat-Peral Pedro , Ortuño Vicente , Yébana Pilar , Al-Shymali Olena , Vega-Estrada Alfredo 
Published: April 2018

Purpose: To evaluate clinical and visual outcomes, quality of near vision, and intraocular optical quality of patients bilaterally implanted with a trifocal PanOptix intraocular lens. Methods: In this prospective consecutive case-series study, 52 eyes of 26 bilateral patients (mean age, 60.2 ± 7.4 years) were implanted with the AcrySof IQ Panoptix intraocular lens. Visual acuity, defocus curve, contrast sensitivity (Pelli-Robson test), near activity visual questionnaire, and internal aberrations with Osiris were evaluated. A prototype light-distortion analyzer was used to quantify the postoperative light-distortion indices. The follow-up was 6 months after surgery. Results: Uncorrected, corrected distance, and uncorrected near visual acuities improved with the surgery (p ≤ 0.02). Distance corrected near visual acuity was 0.13 ± 0.10, 0.13 ± 0.13, and 0.13 ± 0.08 at 1, 3, and 6 months after surgery, respectively (p = 0.82). Distance corrected intermediate visual acuities were 0.09 ± 0.13, 0.13 ± 0.15, and 0.12 ± 0.12 at 1, 3, and 6 months, postoperatively. Binocular contrast sensitivity was 1.86 ± 0.15 Log Units. Defocus curve provided a visual acuity equal or better to 0.30 LogMAR between defocus levels of +0.50 to −3.00 D. The near activity visual questionnaire scores improved significantly with the surgery (p < 0.01). Conclusion: The AcrySof IQ Panoptix intraocular lens is able to restore visual function with an acceptable intermediate and near vision after cataract surgery with good contrast sensitivity and an improvement in the near activity visual questionnaire.
Scanning electron microscopic characteristics of manually loaded and preloaded foldable acrylic intraocular lenses
Authors: Rateb Mahmoud Fathy , Eldaly Zeiad Hasan , Ibrahim Walid Saad Eldein , Eldoghaimy Ahmed Hasan 
Published: April 2018

Purpose: To compare surface alterations between preloaded and manually loaded intraocular lens. Methods: Scanning electron microscope was utilized to evaluate surface alteration and deposits in four different types of intraocular lenses: preloaded hydrophobic acrylic, preloaded hydrophilic acrylic, manually loaded hydrophobic acrylic, and manually loaded hydrophilic acrylic. Six lenses with different powers (+6 D, +22 D, and +29 D) were used from each category, to represent different thickness categories of the intraocular lenses. Results: In total, 30 intraocular lenses have been evaluated in this study: 4 from the control group (2 hydrophobic and 2 hydrophilic lenses) and 12 from the preloaded intraocular lens and manually loaded groups (6 hydrophilic and 6 hydrophobic lenses with different powers). Surface deposits were found in eight hydrophobic intraocular lenses compared to a single intraocular lens with scattered deposits on the optical surface of a hydrophilic intraocular lens. In manually loaded intraocular lens group, five hydrophobic and one hydrophilic intraocular lenses showed identifiable marks on the optical surface. In the preloaded intraocular lens group, three hydrophobic intraocular lenses showed identifiable marks on the optical surface and three hydrophobic intraocular lenses showed surface wrinkling. All hydrophilic intraocular lenses revealed no identifiable marks. Conclusion: Surface alterations and deposits are a common finding in both preloaded and manually loaded intraocular lenses. Water content of acrylic intraocular lenses is an important factor predisposing to these changes, and hydrophobic intraocular lenses are more vulnerable than hydrophilic lenses. The impact on the final visual outcome needs further studies.
Spiritual Formation and St. Paul as Spiritual Director: Determining the Primary Aims
Authors: Copan Victor 
Published: April 2018

Dallas Willard makes the claim that spiritual formation “refers to the Spirit-driven process of forming the inner world of the human self in such a way that it becomes like the inner being of Christ himself.”1 Can this claim be substantiated and stand up to close scrutiny, or is Dallas Willard selecting an idea of his own fancy and making this the cornerstone of his understanding of spiritual formation? How can this claim be tested and anchored? In this article we will seek to answer these questions by looking at the Apostle Paul in his function as spiritual director. Although it is patently anachronistic to speak of Paul as spiritual director, can we legitimately understand him in this role? We will propose a generative understanding of spiritual direction and then proceed to examine the Apostle Paul and his aims based on that generative understanding. We will also argue that at the core of Paul's functioning as a spiritual director lies a strong appeal to examine and imitate his life and character and to follow his ways. This appeal by Paul for others to imitate him is anchored in Paul's own imitation of Christ himself. Paul's call to imitation thus provides a window into discovering how Paul understood his role as spiritual director and also provides us the means to discern his goals in spiritual direction.
Outcomes and Return to Sport After Revision Anterior Cruciate Ligament Reconstruction in Adolescent Athletes
Authors: Saper Michael , Pearce Stephanie , Shung Joseph , Zondervan Robert , Ostrander Roger , Andrews James R. 
Published: April 2018

Background: The number of adolescent anterior cruciate ligament (ACL) injuries is rising with increased participation in higher level athletics at earlier ages. With an increasing number of primary ACL reconstructions (ACLRs) comes a rise in the incidence of revision ACLRs. Purpose: To evaluate the clinical results of revision ACLR across a group of high-level adolescent athletes with at least 2-year follow-up. Study Design: Case series; Level of evidence, 4. Methods: A retrospective review of 21 adolescent athletes (age range, 10-19 years) who underwent revision ACLR with at least 2-year follow-up was conducted. Patient-reported outcome measures (PROMs) included the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Lysholm knee scoring scale, Tegner activity level scale, and modified Cincinnati Knee Rating System. Return to sport (RTS) and overall patient satisfaction were also assessed. Results: The mean age at the time of surgery was 16.5 years (range, 14-19 years), and the mean follow-up was 46.4 months (range, 24-97 months); 42.9% of patients were female, and 52.4% of patients participated in collision sports. The mean time to failure after primary ACLR was 13.1 ± 8.0 months, and the most common mechanism of failure was noncontact in at least 66.7% of cases. The revision graft type included bone–patellar tendon–bone (BPTB) in 71.4% of cases; 26.7% of BPTB grafts were from the contralateral extremity. Concomitant procedures were performed for intra-articular lesions in 71.4% of patients. The mean patient satisfaction rate was 95.3%. There were 3 cases of a graft reinjury at a mean of 25 months postoperatively. The mean PROM scores were as follows: IKDC, 87.5 ± 12.7; Tegner, 7.2 ± 2.0; Lysholm, 93.7 ± 9.8; and Cincinnati, 93.4 ± 10.0. Of those attempting to RTS, 68.4% of patients successfully returned at the same level of competition. Patients with a lateral compartment chondral injury were less likely to RTS ( P < .05). Independent variables shown to have no significant relationship to PROMs or RTS included age, follow-up, sport classification, associated meniscal tears, revision graft size/type, and concomitant procedures. Conclusion: Revision ACLR can be an effective surgical option in adolescents participating in collision and contact sports, with good to excellent subjective outcome scores. At a minimum 2-year follow-up, a graft rupture after revision ACLR occurred in 14% of cases. Of the athletes attempting to RTS, 68.4% returned to their preinjury level of competition.
Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia
Authors: Wang Fan , Demir Salih , Gehringer Franziska , Osswald Clarissa D. , Seyfried Felix , Enzenmüller Stefanie , Eckhoff Sarah M. , Maier Thomas , Holzmann Karlheinz , Debatin Klaus-Michael , Wirth Thomas , Meyer Lüder H. , Ushmorov Alexey 
Published: April 2018

Key Points
FOXO1 activity is essential for growth and maintenance of BCP-ALL. Inhibition of FOXO1 reduces leukemia load and prolongs survival in a preclinical model of BCP-ALL.
A OMC no raio X
Authors: Costa Ligia Maura 
Published: April 2018

Com as transações mercantis crescendo em volume e complexidade, aumentam as exigências para que os setores públicoe privado entendam o funcionamento cada vez mais sofisticado dos mecanismos de controle da Organização Mundial do Comércio (OMC). Como são estabelecidas suas normas e resolvidas as disputas internacionais? Como se preparar para as negociações? Quais as melhores estratégias e táticas? A sobrevivência de empresas e setores inteiros depende, em grande medida, do conhecimento das respostas para essas perguntas.
Woody Allen e o mercado
Authors: Vieira Marcelo Milano Falcão , Lengler Jorge Francisco Bertinetti , Fachin Roberto C. 
Published: April 2018

Instrumento fundamental do marketing e conceito indispensável para a tomada de decisões, a segmentação de mercado pode guardar aspectos insuspeitados – e muito pouco nobres. Inspirado por um filme de Woody Allen, este artigo propõe-se a desconstruir o conceito e mostra que, apesar do recente discurso de reconhecimento e respeito às diferenças, ele mascara e reproduz práticas históricas de discriminação e dominação.
A hora da mudança
Authors: Rego Arménio , Cunha Miguel Pina e 
Published: April 2018

O que fazer quando sua empresa precisa passar por uma mudança, de grande ou de pequeno porte? Quais são os caminhos a serem tomados e quais os obstáculos a serem enfrentados? Este artigo sugere um modelo para a gestão de mudanças planejadas, o V.I.A.R.M.A., que se baseia na tese de que o processo transformacional pode ser realizado de cima para baixo, sustentando-se em dois pilares distintos: liderança e gestão. Somente a conjugação dessas duas dimensões de ação pode garantir o êxito da mudança planejada.
Canal aberto
Authors: Loureiro Sonia 
Published: April 2018

A gestão empresarial está se tornando cada vez mais complexa. Além de competitividade e capacidade de inovação, o contexto de negócios exige das organizações um posicionamento claro acerca de temas como diversidade, direitos humanos, impactos ambientais, saúde e bem-estar dos colaboradores e da comunidade. Algumas questões-chave devem ser respondidas. Como conciliar valores universais com os processos empresariais? Como desenvolver lideranças e profissionais focados na sustentabilidade econômica, social e ambiental? Um caso ocorrido na Natura mostra como, a partir da ação de uma consumidora, a empresa equacionou essas questões e incorporou o conceito de responsabilidade social a seu dia-a-dia.
Ética, ambição e crescimento
Authors: Castro Júnior Paulo G. de 
Published: April 2018

A ética deixou de se limitar ao terreno religioso e filosófico para se tornar também um assunto empresarial. O futuro da sociedade e das empresas nunca esteve tão entrelaçado, e mesmo a ambição – sempre um desafio para o comportamento ético – pode ser transformada em força competitiva. Na ponta desse processo, estão as empresas visionárias: mais humanas, elas abrem horizontes para os negócios e contribuem para aprimorar a ética e a moralidade de todo o corpo social.
Há múltis que precisam aprender a se comportar
Authors: Basile Sidnei 
Published: April 2018

Uma das mais fortes características da globalização é o intercâmbio de informações em tempo real. Mas será que toda essa massa de informações está sendo adequadamente interpretada e utilizada? A atuação de diversas multinacionais no Brasil, em parte instaladas aqui na esteira do processo de privatização, mostra que não. Munidas de informações equivocadas sobre o país, sem compreender a realidade local, elas chegam a agir de maneira desastrada. Investem na melhoria da imagem, mas, paradoxalmente, podem estar prejudicando a própria reputação.
Cláudia Costin
Authors: Goldbaum Sérgio 
Published: April 2018

A atual Secretária Estadual de Cultura, Cláudia Costin, ex-GV, exerceu importantes funções na administração pública federal: na segunda metade da década de 1990, foi Ministra da Administração e da Reforma do Estado e Secretária de Estado da Administração e do Patrimônio. Em dezembro de 1999, assumiu a Gerência do Setor Público do Banco Mundial, em Washington e, depois de rápida incursão pela iniciativa privada, voltou à cena pública. À RAE-executivo, Cláudia fala sobre mudança organizacionale sobre os desafios da gestão pública.
Armadilhas da abertura financeira
Authors: Belluzzo Luiz Gonzaga 
Published: April 2018

Nos últimos 20 anos, a onda de desregulamentação tem atingido os mercados centrais. As palavras de ordem passaram a ser abertura comercial, liberalização das contas de capital, descompressão dos sistemas financeiros domésticos, reforma do Estado, abandono das políticas intervencionistas e câmbio flutuante. Todos os países, incluindo o Brasil, foram afetados por essas novas obrigações econômicas. Este artigo analisa o impacto da liberalização do mercado sobre o crescimento econômico brasileiro.
Made in Brazil
Authors: Santos Rubens da Costa 
Published: April 2018

O marketing de produtos não é um tema restrito a empresas e empresários, nem uma questão baseada apenas no valor intrínseco do produto. Envolve iniciativas bem mais amplas. A Certificação de Origem de produtos é uma delas. Esse “selo” funciona como um certificado de originalidade e diferenciação e permite uma ampliação do valor embutido. Assim, ganha status de segunda marca e pode levar os consumidores a pagarem preços premium por produtos que o exibem.
O fetiche da mudança
Authors: Bendassolli Pedro Fernando 
Published: April 2018

Tome-se qualquer artigo ou livro de gestão e haverá grande chance de encontrar o mesmo argumento, repetido à exaustão: “vivemos em uma época de mudanças”... “para sobreviver, as empresas têm de mudar continuamente, inovando, destruindo velhas estruturas e recriando outras”... “ninguém pode ficar parado ou se tornará obsoleto”. O discurso da mudança foi transformado em uma verdade universal que pode ser menos verdadeira e menos universal do que pensam os mais crédulos.
A prática da estratégia [entrevistado por Marcelo Binder]
Authors: Whittington Richard 
Published: April 2018

As concepções tradicionais atribuem a formulação estratégica a um grupo de elite dentro da organização. Richard Whittington, professor da Said Business School, da Universidade de Oxford, tem um ponto de vista diferente. Durante a Terceira Conferência Internacional da Iberoamerican Academy of Management, ocorrida em São Paulo, o pesquisador concedeu esta entrevista à RAEexecutivo, na qual defende que a estratégia se relaciona às práticas do dia-a-dia e deve envolver todos os gestores.
Democracia digital
Authors: Kujawski Guilherme 
Published: April 2018

O movimento do software livre vem ganhando adeptos no mundo corporativo e entre consumidores domésticos. A principal bandeira do movimento é a oferta de programas de computadores isentos de licenças pagas, dando total liberdade para que os usuários finais os alterem ou adaptem de acordo com suas próprias necessidades. Este artigo mostra a origem e a evolução desse movimento, e os seus impactos sobre indivíduos, empresas e governos.
Luzes nórdicas [entrevistado por Charles Kirschbaum]
Authors: Sevón Guje 
Published: April 2018

Guje Sevón é professora de Psicologia Organizacional da Stockholm University. Per-Olof Berg é presidente da Stockholm School of Entrepreneurship. Durante a Terceira Conferência Internacional da Iberoamerican Academy of Management, ocorrida em São Paulo, os pesquisadores concederam esta entrevista à RAE-executivo, na qual tratam de temas como empreendedorismo, perfil executivo, importação de idéias em gestão e o uso de “performances teatrais” na vida corporativa.
Oportunidades e riscos da diversidade
Authors: Mendes Rodrigo Hübner 
Published: April 2018

Premidas pela necessidade de operar em diferentes nichos de mercado, com distintos perfis de consumidores, muitas empresas vêm procurando refletirinternamente a diversidade externa. Com isso, adotam práticas “politicamente corretas” e procuram atrair para a organização profissionais com perfis variados em termos de sexo, etnia, formação e base cultural. Porém, administrar quadros com grande diversidade apresenta grandes desafios e pode colocar em risco o modelo de gestão e a própria identidadeorganizacional.
The neural determinants of age-related changes in fluid intelligence: a pre-registered, longitudinal analysis in UK Biobank
Authors: Kievit Rogier A. , Fuhrmann Delia , Borgeest Gesa Sophia , Simpson-Kent Ivan L. , Henson Richard N. A. 
Published: April 2018

Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function independently. To support healthy aging, the mechanisms underlying these declines need to be better understood. Methods: In this pre-registered analysis, we applied latent growth curve modelling to investigate the neural determinants of longitudinal changes in fluid intelligence across three time points in 185,317 individuals (N=9,719 two waves, N=870 three waves) from the UK Biobank (age range: 39-73 years). Results: We found a weak but significant effect of cross-sectional age on the mean fluid intelligence score, such that older individuals scored slightly lower. However, the mean longitudinal slope was positive, rather than negative, suggesting improvement across testing occasions. Despite the considerable sample size, the slope variance was non-significant, suggesting no reliable individual differences in change over time. This null-result is likely due to the nature of the cognitive test used. In a subset of individuals, we found that white matter microstructure (N=8839, as indexed by fractional anisotropy) and grey-matter volume (N=9931) in pre-defined regions-of-interest accounted for complementary and unique variance in mean fluid intelligence scores. The strongest effects were such that higher grey matter volume in the frontal pole and greater white matter microstructure in the posterior thalamic radiations were associated with higher fluid intelligence scores. Conclusions: In a large preregistered analysis, we demonstrate a weak but significant negative association between age and fluid intelligence. However, we did not observe plausible longitudinal patterns, instead observing a weak increase across testing occasions, and no significant individual differences in rates of change, likely due to the suboptimal task design. Finally, we find support for our preregistered expectation that white- and grey matter make separate contributions to individual differences in fluid intelligence beyond age.
A NOVEL TREATMENT OF DYE WASTEWATER OF BATIK INDUSTRY BY A COMBINATION OF ALUMINIUM SULFATE AND NATURAL IRON COATED-SAND
Authors: Machdar Izarul 
Published: April 2018

This paper presents the results of dye wastewater treatment of a batik industry in a batch experiment. Theexperiment was carried out by adding a mixture of aluminium sulfate as coagulant and natural iron oxide-coated sand (NICS) into the wastewater. Sedimentation rate of the formed flock was enhanced by a magnet. Initial COD concentration of the dye wastewater of 1060 mg/L was used in the experiment. Results of this research showed that the efficiency of the dye removal and settling time were affected by iron sandentrapped in the formed flocks. The highest efficiency of COD removal was 95%, or similar to the finalCOD concentration of 45 mg/L at settling time of 10 minutes. It could be concluded that the combination ofaluminium sulfate and NICS could effectively be used in the treatment of the dye wastewater from batikindustry.
DAMPAK PERTUMBUHAN PENDUDUK TERHADAP BEBAN SUMBER PENCEMAR DI DANAU SENTANI DENGAN MODEL SISTEM DINAMIK BERWAWASAN LINGKUNGAN
Authors: Walukow Auldry F. 
Published: April 2018

Penelitian ini bertujuan untuk menganalisis erosi di daerah pengaliran sungai (DPS) Sentani dan mengaplikasi model sistem dinamik untuk menganalisis pengaruh pertumbuhan penduduk terhadap beban sumber pencemar Danau Sentani. Metode yang digunakan adalah Universal Soil Loss Equation (USLE) untuk memprediksi erosi dari bidang tanah dan model sistem dinamik dengan menggunakan tool powersim 2.5d untuk memperoleh model pengelolaan Danau Sentani yang berkelanjutan. Hasil penelitian menunjukkan bahwa pendekatan model dinamik untuk pengelolaan dan perencanaan wilayah permukiman dan pertanian di sekitar Danau Sentani dapat membantu untuk mengetahui perkembangan sumber-sumber pencemar, erosi, dan batas waktu habisnya luas hutan, sehingga kebijakan strategis berkaitan dengan degradasi DPS Sentani dapat diantisipasi secara lebih dini. Selain itu, pertambahan penduduk merupakan faktor pengungkit (leverage factor) terhadap peningkatan sumber pencemar, keterbatasan lahan hutan, erosi lahan permukiman, dan erosi lahan pertanian. Namun perlu juga dilakukan intervensi struktural terhadap luas lahan permukiman dan luas lahan pertanian. Model dinamik sumber pencemar merupakan bentuk Archetype Shifting the Burden.