bluuebunny/crossref_metadata_2025_split huggingface dataset:
India Research Management Initiative (IRMI) – an initiative for building research capacity in India
Authors: Ayyar Savita , Jameel Shahid 
Published: January 2019

Research and innovation are growing in India with significant investments being made towards institutions, researchers and research infrastructure. Although still under 1% of GDP, funding for science and technology in India has increased each year for over two decades. There is also increasing realization that public funding for research should be supplemented with that from industry and philanthropy. Like their counterparts worldwide, Indian researchers require access to professional research management support at their institutions to fully leverage emerging scientific opportunities and collaborations. However, there are currently significant gaps in the research management support available to these researchers and this has implications for research in India. The India Research Management Initiative (IRMI) was launched by the Wellcome Trust/DBT (Department of Biotechnology, Government of India) India Alliance (hereafter India Alliance) in February 2018 to narrow these gaps. A 12-month pilot phase has enabled conversations across multiple stakeholders. In this Open Letter, we share some insights from the IRMI pilot phase, which could aid systemic development and scaling up of research management as a professional support service across India. We anticipate these will stimulate dialogue and guide future policy and interventions towards building robust research and innovation ecosystems in India.
O OUTRO LADO DA MOEDA NA NOVA RELACAO ENTRE FISCO E CONTRIBUINTES – A OBRIGACAO DE REVELAR PLANEJAMENTOS FISCAIS AGRESSIVOS / THE OTHER SIDE OF THE COIN IN THE NEW RELATIONSHIP BETWEEN TAX AUTHORITIES AND TAX PAYERS – MANDATORY DISCLOSURE RULES ON AGGRESSIVE TAX PLANNING
Authors: Parada Marcio Henrique Sales 
Published: January 2019

A tributação, enquanto elemento primordial na atividade estatal, é sempre um campo fértil para discussões acadêmicas, frequentemente de caráter multidisciplinar. A relação entre Fisco e contribuintes, especialmente no que diz respeito a transparência e confiança, vem sendo desenvolvida, há anos, em vários países que decidiram migrar de um modelo baseado nas auditorias e aplicação de punições para um modelo fundado na autorregularização, muitas vezes com supervisão ou acompanhamento da administração tributária. Este artigo, partindo das propostas de uma nova dimensão nessa relação, no caminho que finalmente a Administração Tributária brasileira encontra no sentido de fortalecer o cumprimento voluntário de obrigações fiscais, dispõe-se a analisar a possibilidade da introdução, no sistema tributário, de ações com o escopo de determinar a revelação de planejamentos tributários agressivos, assim entendidos aqueles que produzam vantagens fiscais, conforme proposto pela Organização para a Cooperação e o Desenvolvimento Econômico. O trabalho reconhece que tal modelo contém nuances ainda não exploradas. A análise descritiva realiza uma comparação entre sistemas em vigor e propostas recentes nesse sentido, em países europeus, focando no tempo da informação e nos sujeitos da obrigação, para concluir que conjuntos de regras que determinam a revelação de planejamento tributário agressivo devem estar ligadas a dois outros tipos de programas: a troca de informação entre as administrações tributárias e programas de compliance cooperativo. Além disso, analisando uma experiência frustrada brasileira, o artigo reflete sobre possíveis questões envolvendo princípios constitucionais que precisam ser considerados na aplicação desse tipo de sistema e endereça para futuros estudos no tocante a sigilo profissional, privacidade e intimidade.
What does the NHS Long Term Plan mean for diabetes care?
Authors: Phillips Anne 
Published: January 2019

The NHS Long Term Plan, launched in January 2019, outlined several targets and schemes to improve patient care. However, practice nurses need to be aware of what these changes might mean for their practice, particularly in diabetes care This is an exciting time of transformation and engagement in diabetes care for general practice. The King's Fund (2018) reported ‘a shared responsibility for health’ which echoes this vision for transformation in terms of diabetes care and supporting more avenues to enable people to gain the skills and knowledge to live well with their condition. Furthermore, the new NHS Long Term Plan ( NHS, 2019 ) announced several initiatives for people living with diabetes, which are detailed in this article.
Double-level fixator-assisted nailing (DL-FAN)
Authors: Chaudhary M. M. , Lakhani P. H. 
Published: January 2019

Aims Double-level lengthening, bone transport, and bifocal compression-distraction are commonly undertaken using Ilizarov or other fixators. We performed double-level fixator-assisted nailing, mainly for the correction of deformity and lengthening in the same segment, using a straight intramedullary nail to reduce the time in a fixator. Patients and Methods A total of 23 patients underwent this surgery, involving 27 segments (23 femora and four tibiae), over a period of ten years. The most common indication was polio in ten segments and rickets in eight; 20 nails were inserted retrograde and seven antegrade. A total of 15 lengthenings were performed in 11 femora and four tibiae, and 12 double-level corrections of deformity without lengthening were performed in the femur. The mean follow-up was 4.9 years (1.1 to 11.4). Four patients with polio had tibial lengthening with arthrodesis of the ankle. We compared the length of time in a fixator and the external fixation index (EFI) with a control group of 27 patients (27 segments) who had double-level procedures with external fixation. The groups were matched for the gain in length, age, and level of difficulty score. Results The mean gain in length was statistically similar in the two groups: 3.9 cm (1.5 to 9.0) in the study group and 4.2 cm (3.4 to 5.0) in the control group (p = 0.350). The mean time in a fixator was significantly less in the study group compared with the control group: 8.6 weeks (2.0 to 22.8) versus 30.2 weeks (25.0 to 35.4; p < 0.001). The mean EFI was significantly lower in the study group compared with the control group: 17.7 days/cm (10.6 to 35.6) versus 73.4 days/cm (44.5 to 102.3; p < 0.001). The ASAMI (Association for the Study and Application of the Method of Ilizarov) bone score was excellent in 22, good in four, and fair in one. The ASAMI functional score was excellent in 20 and good in seven. There were no infections, superficial or deep. Conclusion Double-level osteotomies or two procedures using a custom-made straight nail and external fixation can be used to correct deformities or to treat nonunion or malunion and may be combined with arthrodesis of the ankle with lengthening. It is a reasonably safe procedure that allows accurate and cost-effective treatment with a relatively short time in a fixator.
Transfemoral amputation following total knee arthroplasty
Authors: Ryan S. P. , DiLallo M. , Klement M. R. , Luzzi A. J. , Chen A. F. , Seyler T. M. 
Published: January 2019

AimsThe aim of this study was to characterize the factors leading to transfemoral amputation after total knee arthroplasty (TKA), as well as the rates of mortality and functional independence after this procedure in these patients.Patients and MethodsThis was a multicentre retrospective review with a prospective telephone survey for the assessment of function. All patients with a TKA who subsequently required transfemoral amputation between January 2001 and December 2015 were included. Demographic information, medical comorbidities, and postoperative mortality data were collected. A 19-item survey was used for the assessment of function in surviving patients.ResultsA total of 111 patients were included. Their mean age was 61.0 years (42.0 to 88.0) at the time of TKA, with a subsequent mean of 3.7 operations (0 to 15) over a mean period of 6.1 years (0.05 to 30.1) before amputation. The indication for amputation was chronic infection in 97 patients (87.4%). The rate of five-year survival was 51.7%, and advanced age (p = 0.001) and renal failure (p = 0.045) were associated with an increased risk of mortality. Of the 62 surviving patients, 34 completed the survey; 32 (94.1%) owned a prosthesis but only 19 (55.9%) used it; 19 (55.9%) primarily used a wheelchair for mobility; 27 (79.5%) had phantom pain; and 16 (47.1%) required chronic pain medication. Only 18 patients (52.9%) were satisfied with the quality of life.ConclusionPatients with complications after TKA, in whom transfemoral amputation is considered, should be made aware of the high rate of mortality and the poor functional outcome in the survivors. Alternative forms of treatment including arthrodesis of the knee should be investigated.
Neoadjuvant denosumab
Authors: Puri A. , Gulia A. , Hegde P. , Verma V. , Rekhi B. 
Published: January 2019

Aims The aims of this study were to evaluate the efficacy of preoperative denosumab in achieving prospectively decided intention of therapy in operable giant cell tumour of bone (GCTB) patients, and to document local recurrence-free survival (LRFS). Patients and Methods A total of 44 patients received preoperative denosumab: 22 to facilitate curettage, 16 to facilitate resection, and six with intent of converting resection to curettage. There were 26 male and 18 female patients. The mean age was 27 years (13 to 47). Results The mean number of denosumab treatments was five (2 to 7) per patient. In 42 of 44 patients (95%), denosumab helped to achieve prospectively decided intention. A total of 41 patients were available for follow-up at a mean follow-up of 34 months (24 to 48). There were 12 local recurrences (29%), in 11 patients (11/25, 44%) who had curettage and in one patient (1/16, 6%) who had resection. The mean time to local recurrence was 16 months (8 to 25). The LRFS was 76% at two years: 94% for cases with resection and 64% for cases with curettage (p = 0.013). Conclusion Although local control rates are unlikely to improve with use of preoperative denosumab, a short preoperative course of denosumab can facilitate surgery in certain cases of operable GCTB, with a high risk of local recurrence making curettage or resection technically easier. It may also help in converting a lesion requiring resection to a lesion that could possibly be treated with curettage.
The influence of developmental spinal stenosis on the risk of re-operation on an adjacent segment after decompression-only surgery for lumbar spinal stenosis
Authors: Cheung P. W. H. , Fong H. K. , Wong C. S. , Cheung J. P. Y. 
Published: January 2019

AimsThe aim of this study was to determine the influence of developmental spinal stenosis (DSS) on the risk of re-operation at an adjacent level.Patients and MethodsThis was a retrospective study of 235 consecutive patients who had undergone decompression-only surgery for lumbar spinal stenosis and had a minimum five-year follow-up. There were 106 female patients (45.1%) and 129 male patients (54.9%), with a mean age at surgery of 66.8 years (sd 11.3). We excluded those with adult deformity and spondylolisthesis. Presenting symptoms, levels operated on initially and at re-operation were studied. MRI measurements included the anteroposterior diameter of the bony spinal canal, the degree of disc degeneration, and the thickness of the ligamentum flavum. DSS was defined by comparative measurements of the bony spinal canal. Risk factors for re-operation at the adjacent level were determined and included in a multivariate stepwise logistic regression for prediction modelling. Odds ratios (ORs) with 95% confidence intervals were calculated.ResultsOf the 235 patients, 21.7% required re-operation at an adjacent segment. Re-operation at an adjacent segment was associated with DSS (p = 0.026), the number of levels decompressed (p = 0.008), and age at surgery (p = 0.013). Multivariate regression model (p < 0.001) controlled for other confounders showed that DSS was a significant predictor of re-operation at an adjacent segment, with an adjusted OR of 3.93.ConclusionPatients with DSS who have undergone lumbar spinal decompression are 3.9 times more likely to undergo future surgery at an adjacent level. This is a poor prognostic indicator that can be identified prior to index decompression surgery.
Plasma MicroRNA Signature Validation for Early Detection of Colorectal Cancer
Authors: Herreros-Villanueva Marta , Duran-Sanchon Saray , Martín Ana Carmen , Pérez-Palacios Rosa , Vila-Navarro Elena , Marcuello María , Diaz-Centeno Mireia , Cubiella Joaquín , Diez Maria Soledad , Bujanda Luis , Lanas Angel , Jover Rodrigo , Hernández Vicent , Quintero Enrique , José Lozano Juan , García-Cougil Marta , Martínez-Arranz Ibon , Castells Antoni , Gironella Meritxell , Arroyo Rocio 
Published: January 2019

OBJECTIVES:
Specific microRNA (miRNA) signatures in biological fluids can facilitate earlier detection of the tumors being then minimally invasive diagnostic biomarkers. Circulating miRNAs have also emerged as promising diagnostic biomarkers for colorectal cancer (CRC) screening. In this study, we investigated the performance of a specific signature of miRNA in plasma samples to design a robust predictive model that can distinguish healthy individuals from those with CRC or advanced adenomas (AA) diseases.

METHODS:
Case control study of 297 patients from 8 Spanish centers including 100 healthy individuals, 101 diagnosed with AA, and 96 CRC cases. Quantitative real-time reverse transcription was used to quantify a signature of miRNA (miRNA19a, miRNA19b, miRNA15b, miRNA29a, miRNA335, and miRNA18a) in plasma samples. Binary classifiers (Support Vector Machine [SVM] linear, SVM radial, and SVM polynomial) were built for the best predictive model.

RESULTS:
Area under receiving operating characteristic curve of 0.92 (95% confidence interval 0.871–0.962) was obtained retrieving a model with a sensitivity of 0.85 and specificity of 0.90, positive predictive value of 0.94, and negative predictive value of 0.76 when advanced neoplasms (CRC and AA) were compared with healthy individuals.

CONCLUSIONS:
We identified and validated a signature of 6 miRNAs (miRNA19a, miRNA19b, miRNA15b, miRNA29a, miRNA335, and miRNA18a) as predictors that can differentiate significantly patients with CRC and AA from those who are healthy. However, large-scale validation studies in asymptomatic screening participants should be conducted.
Music, Dance and the Sama-Bajau ‘Diaspora’: Understanding Aspects of Links among Communities through Ethnochoreomusicological Perspectives
Authors: Santamaria Matthew Constancio Maglana 
Published: January 2019

Rituals in establishing the cultural as well as links among Sama-Bajau communities across Nusantaraor the region that we know as maritime Southeast Asia. Ritual, however, cannot be fully understood unless it is broken into component parts of tangible (material) and intangible (non-material) properties. In this paper, I argue that an ethnochoreo-musicological approach, particularly through the examination of specific music pieces and dance forms or styles, can help scholars understand how the seemingly disparate and widely-spread Sama-Bajau communities in Nusantaraare related to each other. Three cases are presented revolving around ritual, music, and dance. The first case is about the magpai-bahauor ritual of the new rice which is shared by most Sama-Bajau communities in the Sulu-Sulawesi region. Rice from one community is passed on to another, constituting a virtual chain link that reaffirms the bonds between two groups of people. Corollary to this shared ritual practice is the shared repertoire of music(s) and dance(s). The second case concerns the musical model of Titik Tabawan, a kulintangan(aka tagunggo’an) graduated bossed-gong ensemble music piece composed of a distinct combination of melodic and rhythmic patterns that is observed as a ‘universally-shared’ intangible property in the central region of Nusantara. Although known by different names across communities, this music piece, which is used for accompanying secular forms belonging to the Sama-Bajau igalor pansak(aka pamansak) dance traditions, retains its distinct qualities of rhythmic patterns and remains discernible as a musical model to both practitioners and scholars alike. Finally, the third case illustrates how variants of Igal Tarirai, a percussive dance using bamboo clappers called bola’-bola,’ may be used to glean relative distance or proximity in terms of dance performance practice.
System identification of a robot arm with extended Kalman filter and artificial neural networks
Authors: Horvath Sabine , Neuner Hans 
Published: January 2019

Abstract
The development of an algorithm to describe a dynamic system and to predict its future behaviour in further consequence is the aim of the present study. Non parametric models provide a general description of object dynamics and artificial neural networks (ANN), which are a very flexible and universal learning method, belong to it. However, the standard estimation procedures for ANN like Levenberg-Marquardt (LM) do not consider that data is observed and consequently is uncertain. The combination with the extended Kalman filter (EKF) enables the consideration of the uncertainty in the estimation process. The analogies between EKF and LM are discussed and thereon the advantages of the EKF are outlined.
The integration of ANN into EKF will be evaluated on an industrial robot arm. At first, a simplified model is determined; the ANN describes the robot position deviations as a function of the joint encoder values. The robot reference positions are measured by a laser tracker. In order to compare it with the robot outputs, the observations need to be transformed to the robot frame and the offset between the end-effector and the robot flange has to be determined. A method to estimate both parameters simultaneously is developed and the results are verified on basis of simulated data.
This paper comprises two novel approaches. First, uncertainty is considered in the ANN estimation on basis of the combination with the EKF. Considering the full covariance matrix of the robot deviations leads to a better prediction of the robot’s behaviour. Second, an integrated transformation and lever arm determination is introduced and the robot’s repeatability presents the limiting factor of the achievable parameter uncertainty.
Performance Enhancement in Colorless WDM–PON Using SSB-SC
Authors: Bharti Manisha 
Published: January 2019

Abstract
In this manuscript, an attempt has been made to enhance the performance of colorless wavelength division multiplexed-passive optical network (WDM–PON) system using a combination of dual-drive Mach–Zehnder modulator and single sideband-suppressed carrier (SSB-SC) technique along with splicing. The proposed design makes use of SSB-SC technique for optical line terminal (OLT) as well as for optical network unit (ONU) that is generated by using dual-drive modulator which in turn reduces the expense for complete communication process. Suppressed RF signals with four channels at a bit rate of 10 Gbps for each channel are multiplexed before injecting into fiber span of 25 km at OLT side. Half of the downlink power is consumed for re-modulating the data signal at ONU side. The performance is further improved by using signal splicing method. Due to suppression in the carrier in this technique, there is no carrier Rayleigh scattering problem. The proposed model is compared with the existing one for error-free transmission of signal. The results revealed that the proposed model possess less value of bit error rate with the same value of received optical power as well as channel.
Contrasting variations in the diet of the Andean fox Lycalopex culpaeus Molina, 1782 on geographical and environmental scales in the Atacama Desert
Authors: Carevic Felipe S. , Carmona Erico R. , Cartes Francisco , Taucare Felipe 
Published: January 2019

Abstract
We determined the seasonal diet of the Andean fox Lycalopex culpaeus in three habitats in the Atacama Desert, northern Chile, by analyzing their scat contents. We estimated the biomass and the number of individuals of each prey species consumed and compared our results with those of other studies on Lycalopex foxes in Chile and South America. In general, the L. culpaeus diet was characterized by a generalist behavior and higher dietary breadth than those in other ecosystems. In contrast with the other biomes of southern Chile and South America, insects represented the most frequent prey species in the present study and the main food item, comprising more than 50% of all prey at the three study sites; however, in terms of biomass, rodent and reptile prey showed the highest percentage from summer to winter. Significant differences were found between the biomass consumed among sites. Likewise, we found a relationship between the niche breadth of the diet and the primary productivity of the sites. Statistically significant differences in prey items consumed were noted across seasons and sites located at different altitudes, which reflected an opportunistic response to the availability of prey. Our report contributes to current data about the natural history of L. culpaeus in hyper-arid habitats.
Univariate approximating schemes and their non-tensor product generalization
Authors: Mustafa Ghulam , Bashir Robina 
Published: January 2019

AbstractThis article deals with univariate binary approximating subdivision schemes and their generalization to non-tensor product bivariate subdivision schemes. The two algorithms are presented with one tension and two integer parameters which generate families of univariate and bivariate schemes. The tension parameter controls the shape of the limit curve and surface while integer parameters identify the members of the family. It is demonstrated that the proposed schemes preserve monotonicity of initial data. Moreover, continuity, polynomial reproduction and generation of the schemes are also discussed. Comparison with existing schemes is also given.
Crystal structure of dichlorido-([2,2′:6′,2′′-terpyridine]-4′-carboxylic acid-κ3
N,N′,N′′)copper(II) monohydrate, C16H13Cl2CuN3O3
Authors: Feng Xuan , Yang Zhannan , Li Xin-Hua 
Published: January 2019

Abstract
C16H13Cl2CuN3O3, monoclinic, P21/c (no. 14), a = 11.2656(9) Å, b = 17.1737(14) Å, c = 8.7774(7) Å, β = 98.1940(10)°, V = 1680.8(2) Å3, Z = 4, R
gt(F) = 0.0270, wR
ref(F
2) = 0.0852, T = 298(2) K.
Effects of temperature on white water treatment by the dominant bacteria
Authors: Lan Hui-xia , Yang Da , Zhang Hao , Qiao Hong-jian , Guo Chun-qian , Lv Ya-xu , Zhang Heng 
Published: January 2019

Abstract
Three dominant bacteria including Virgibacillus pantothenticus, Bacillus cereus, and Bacillus subtilis were screened from an activated sludge domesticated via white water in the laboratory. The treatment effects of chemical oxygen demand (COD), electrical conductivity and cationic demand (CD) of the white water by three dominant bacteria were studied in different temperatures. The results showed that the optimum metabolic temperature of the three dominant bacteria was 30 °C with the tested range of 20 °C to 60 °C. The best treatment effect was tended to be stable at a hydraulic retention time of 14 h, COD removal rate was 67.69 %, 77 % and 75.38 %, the electrical conductivity decreased by 0.86 mS/cm, 0.86 mS/cm and 0.62 mS/cm and the CD decreased by 45.61 %, 73.68 % and 50 % for V. pantothenticus, B. cereus, and B. subtilis, respectively.