bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulfation Roasting Mechanism for Spent Lithium-Ion Battery Metal Oxides Under SO2-O2-Ar Atmosphere
Authors: Shi Junjie , Peng Chao , Chen Min , Li Yun , Eric Hurman , Klemettinen Lassi , Lundström Mari , Taskinen Pekka , Jokilaakso Ari 
Published: September 2019

Abstract
Sulfation roasting followed by water leaching has been proposed as an alternative route for recycling valuable metals from spent lithium-ion batteries (LIBs). In the present work, the reaction mechanism of the sulfation roasting of synthetic LiCoO2 was investigated by both thermodynamic calculations and roasting experiments under flowing 10% SO2-1% O2-89% Ar gas atmosphere at 700°C. The products and microstructural evolution processes were characterized by x-ray diffraction, scanning electron microscope and energy dispersive x-ray spectrometer, and atomic absorption spectroscopy. It was confirmed that Co3O4 was formed as an intermedia product, and the final roasted products were composed by Li2SO4, Li2Co(SO4)2, and CoO. The leaching results indicated that 99.5% Li and 17.4% Co could be recovered into water after 120 min of roasting. The present results will provide the basis and solid guidelines for recycling of Li and Co from spent LIBs.
The use of lighting simulation in the evidence-based design process: A case study approach using visual comfort analysis in offices
Authors: Davoodi Anahita , Johansson Peter , Aries Myriam 
Published: September 2019

Abstract
The EBD-SIM (evidence-based design, simulation) framework is a conceptual framework developed to integrate the use of lighting simulation in the EBD process to provide a holistic performance evaluation method. A real-time case study, executed in a fully operational office building, is used to demonstrate the framework’s performance. The case study focused on visual comfort analysis. The objective is to demonstrate the applicability of the developed EBD-SIM framework using correlations between current visual comfort metrics and actual human perception as evaluation criteria. The data were collected via simulation for visual comfort analysis and via questionnaires for instantaneous and annual visual comfort perception. The study showed that for user perception, the most crucial factor for visual comfort is the amount of light on a task area, and simple metrics such as Eh-room and Eh-task had a higher correlation with perceived visual comfort than complex performance metrics such as Daylight Autonomy (DA). To improve the design process, the study suggests that, among other things, post-occupancy evaluations (POEs) should be conducted more frequently to obtain better insight into user perception of daylight and subsequently use new evidence to further improve the design of the EBD-SIM model.
Interaction between hydraulic fractures and natural fractures: current status and prospective directions
Authors: Kolawole Oladoyin , Ispas Ion 
Published: September 2019

AbstractHydraulic fracturing treatment is one of the most efficient conventional matrix stimulation techniques currently utilized in the petroleum industry. However, due to the spatiotemporal complex nature of fracture propagation in a naturally- and often times systematically fractured media, the influence of natural fractures (NF) and in situ stresses on hydraulic fracture (HF) initiation and propagation within a reservoir during the hydrofracturing process remains an important issue. Over the past 50 years of advances in the understanding of HF–NF interactions, no comprehensive revision of the state of the knowledge exists. Here, we reviewed over 140 scientific articles on investigations of HF–NF interactions, published over the past 50 years. We highlight the most commonly observed HF–NF interactions and their implications for unconventional oil and gas production. Using observational and quantitative analyses, we find that numerical modeling and simulation is the most prominent method of approach, whereas there are less publications on the experimental approach, and analytical method is the least utilized approach. Further, we suggest how HF–NF interactions can be monitored in real time on the field during a pre-frac test. Lastly, based on the results of our literature review, we recommend promising areas of investigation that may provide more profound insights into HF–NF interactions in such a way that can be directly applied to the optimization of fracture-stimulation field operations.
Refractory psycho-existential distress and continuous deep sedation until death in palliative care: The French perspective
Authors: Reich Michel , Bondenet Xavier , Rambaud Laurence , Ait-Kaci Fazya , Sedda Anne-Laure , Da Silva Arlette , Villet Stéphanie , Gamblin Vincent 
Published: September 2019

AbstractObjectiveSince February 2016, French Claeys-Leonetti law has recognized patients' right to confront incurable diseases with short-term prognosis and refractory physical or psychological or existential symptoms by requesting continuous deep sedation until death (CDSUD). Determining when psychological or existential distress is refractory and unbearable remains complex and controversial.This review provides a comprehensive thought on CDSUD for advanced incurable patients with refractory psychological and/or existential distress in palliative care settings. It offers guidance on psychiatric or psychological diagnosis for explaining patients' requests for CDSUD.MethodA narrative literature review (2000–2019) was conducted on the MedLine search about the use of palliative sedation in cases of refractory psychological and/or existential distress.Results(1) Definitions of “refractory symptom,” “refractory psychological distress,” and “refractory existential distress” are inconsistent; (2) alternative diagnoses might obscure or be obscured by psycho-existential distress; and (3) criteria on meanings, reasons for requests, decision-making processes, and functions are evolving in practice.Significance of resultsBefore implementing CDSUD, palliative healthcare professionals should seek input from psycho-oncologists in palliative care. Mental health professionals should analyze and assess the reasons for psychological and/or existential distress, consider the intentionality processes of requests, and explore alternative diagnoses, such as depressive or adjustment disorders, demoralization syndrome, desire to hasten death, and desire for euthanasia. Therapeutic responses (e.g., pharmacological and psychotherapeutic) should be implemented before deciding that psycho-existential distress is refractory.
Biologically encoded magnonics
Authors: Zingsem Benjamin W. , Feggeler Thomas , Terwey Alexandra , Ghaisari Sara , Spoddig Detlef , Faivre Damien , Meckenstock Ralf , Farle Michael , Winklhofer Michael 
Published: September 2019

AbstractSpin wave logic circuits using quantum oscillations of spins (magnons) as carriers of information have been proposed for next generation computing with reduced energy demands and the benefit of easy parallelization. Current realizations of magnonic devices have micrometer sized patterns. Here we demonstrate the feasibility of biogenic nanoparticle chains as the first step to truly nanoscale magnonics at room temperature. Our measurements on magnetosome chains (ca 12 magnetite crystals with 35 nm particle size each), combined with micromagnetic simulations, show that the topology of the magnon bands, namely anisotropy, band deformation, and band gaps are determined by local arrangement and orientation of particles, which in turn depends on the genotype of the bacteria. Our biomagnonic approach offers the exciting prospect of genetically engineering magnonic quantum states in nanoconfined geometries. By connecting mutants of magnetotactic bacteria with different arrangements of magnetite crystals, novel architectures for magnonic computing may be (self-) assembled.
3/2 fractional quantum Hall plateau in confined two-dimensional electron gas
Authors: Fu Hailong , Wu Yijia , Zhang Ruoxi , Sun Jian , Shan Pujia , Wang Pengjie , Zhu Zheyi , Pfeiffer L. N. , West K. W. , Liu Haiwen , Xie X. C. , Lin Xi 
Published: September 2019

AbstractEven-denominator fractional quantum Hall (FQH) states, such as 5/2 and 7/2, have been well known in a two-dimensional electron gas (2DEG) for decades and are still investigated as candidates of non-Abelian statistics. In this paper, we present the observation of a 3/2 FQH plateau in a single-layer 2DEG with lateral confinement at a bulk filling factor of 5/3. The 3/2 FQH plateau is quantized at $$\left( {\frac{h}{{e^2}}} \right)/\left( {\frac{3}{2}} \right)$$

h

e

2

∕

3

2

within 0.02%, and can survive up to 300 mK. This even-denominator FQH plateau may imply intriguing edge structure and excitation in FQH system with lateral confinement. The observations in this work demonstrate that understanding the effect of the lateral confinement on the many-body system is critical in the pursuit of important theoretical proposals involving edge physics, such as the demonstration of non-Abelian statistics and the realization of braiding for fault-tolerant quantum computation.
The role of marine sediment diagenesis in the modern oceanic magnesium cycle
Authors: Berg Richard D. , Solomon Evan A. , Teng Fang-Zhen 
Published: September 2019

AbstractThe oceanic magnesium cycle is largely controlled by continental weathering and marine authigenic mineral formation, which are intimately linked to long-term climate. Uncertainties in the magnesium cycle propagate into other chemical budgets, and into interpretations of paleo-oceanographic reconstructions of seawater δ26Mg and Mg/Ca ratios. Here, we produce a detailed global map of the flux of dissolved magnesium from the ocean into deeper marine sediments (greater than ∼1 meter below seafloor), and quantify the global flux and associated isotopic fractionation. We find that this flux accounts for 15–20% of the output of magnesium from the ocean, with a flux-weighted fractionation factor of ∼0.9994 acting to increase the magnesium isotopic ratio in the ocean. Our analysis provides the best constraints to date on the sources and sinks that define the oceanic magnesium cycle, including new constraints on the output flux of magnesium and isotopic fractionation during low-temperature ridge flank hydrothermal circulation.
Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production
Authors: Salazar-León Jonathan , Valdez-Hernández Ana Laura , García-Jiménez Sara , Román-Domínguez Luis , Huanosta-Murillo Enrique , Bonifaz Laura C. , Pérez-Martínez Leonor , Pedraza-Alva Gustavo 
Published: September 2019

AbstractObesity-induced inflammation, triggered by lipid-mediated activation of the Nlrp3 inflammasome, results in glucose metabolism alterations and type 2 diabetes. This knowledge has been generated using animals deficient for any of the different components of this inflammasome (Caspase-1, Asc or Nlrp3) in the C57BL/6 background. Unlike C57BL/6 mice, which carry allele 2 of the Nlrp1b gene (Nlrp1b2), Balb/c mice that carry allele 1 (Nlrp1b1) are less prone to develop alterations in the glucose metabolism when fed with a high fat diet. However, the molecular bases for these metabolic differences are unknown. Here we show that the Nlrp1b1 allele down regulates the adipose tissue inflammatory response attenuating glucose intolerance and insulin resistance in obese C57BL/mice. Our results indicate that the positive effects of the Nlrp1b1 inflammasome on glucose tolerance and insulin sensitivity involve IL-18-mediated effects on lipolysis, pointing out that differential expression of allelic variants of genes coding for inflammasome components might control susceptibility or resistance to develop diabetes in obese individuals.
Mining MYB transcription factors from the genomes of orchids (Phalaenopsis and Dendrobium) and characterization of an orchid R2R3-MYB gene involved in water-soluble polysaccharide biosynthesis
Authors: He Chunmei , Teixeira da Silva Jaime A. , Wang Haobin , Si Can , Zhang Mingze , Zhang Xiaoming , Li Mingzhi , Tan Jianwen , Duan Jun 
Published: September 2019

AbstractMembers of the MYB superfamily act as regulators in a wide range of biological processes in plants. Despite this, the MYB superfamily from the Orchidaceae has not been identified, and MYB genes related to bioactive water-soluble polysaccharide (WSP) biosynthesis are relatively unknown. In this study, we identified 159 and 165 MYB genes from two orchids, Phalaenopsis equestris and Dendrobium officinale, respectively. The MYB proteins were classified into four MYB classes in both orchids: MYB-related (MYBR), R2R3-MYB, 3R-MYB and atypical MYB proteins. The MYBR proteins in both orchids were classified into five subfamilies and 12 genes were strongly up-regulated in response to cold stress in D. officinale. The R2R3-MYB proteins were both divided into 31 clades in P. equestris and D. officinale. Among these clades, nine contained MYB TFs related to secondary cell wall biosynthesis or testa mucilage biosynthesis in Arabidopsis thaliana. In D. officinale, 10 candidate genes showed an expression pattern corresponding to changes in the WSP content. Overexpression of one of these candidate genes (DoMYB75) in A. thaliana increased seed WSP content by about 14%. This study provides information about MYB genes in two orchids that will further help to understand the transcriptional regulation of WSP biosynthesis in these orchids as well as other plant species.
Echo State Networks with Self-Normalizing Activations on the Hyper-Sphere
Authors: Verzelli Pietro , Alippi Cesare , Livi Lorenzo 
Published: September 2019

AbstractAmong the various architectures of Recurrent Neural Networks, Echo State Networks (ESNs) emerged due to their simplified and inexpensive training procedure. These networks are known to be sensitive to the setting of hyper-parameters, which critically affect their behavior. Results show that their performance is usually maximized in a narrow region of hyper-parameter space called edge of criticality. Finding such a region requires searching in hyper-parameter space in a sensible way: hyper-parameter configurations marginally outside such a region might yield networks exhibiting fully developed chaos, hence producing unreliable computations. The performance gain due to optimizing hyper-parameters can be studied by considering the memory–nonlinearity trade-off, i.e., the fact that increasing the nonlinear behavior of the network degrades its ability to remember past inputs, and vice-versa. In this paper, we propose a model of ESNs that eliminates critical dependence on hyper-parameters, resulting in networks that provably cannot enter a chaotic regime and, at the same time, denotes nonlinear behavior in phase space characterized by a large memory of past inputs, comparable to the one of linear networks. Our contribution is supported by experiments corroborating our theoretical findings, showing that the proposed model displays dynamics that are rich-enough to approximate many common nonlinear systems used for benchmarking.
Cisplatin bioconjugated enzymatic GNPs amplify the effect of cisplatin with acquiescence
Authors: Iram Sana , Zahera Manaal , Wahid Iram , Baker Abu , Raish Mohammad , Khan Altaf , Ali Naushad , Ahmad Saheem , Khan Mohd Sajid 
Published: September 2019

AbstractEnzymatic gold nanoparticles (B-GNPs) have been synthesized using a natural anticancer agent bromelain (a cysteine protease) and these nanoparticles were used to bioconjugate Cisplatin (highly effective against osteosarcoma and lung cancer). Cisplatin bioconjugated bromelain encapsulated gold nanoparticles (B-C-GNPs) were found profoundly potent against same cancers at much lower concentration with minimum side effects due to the synergistic effect of bromelain. The B-C-GNPs have been observed to inhibit the proliferation of osteosarcoma cell lines Saos-2 and MG-63 with IC50estimation of 4.51 µg/ml and 3.21 µg/ml, respectively, and against small lung cancer cell line A-549 with IC502.5 µg/ml which is lower than IC50of cisplatin against same cell lines. The B-GNPs/B-C-GNPs were characterized by TEM, UV-Visible spectroscopy, Zeta potential and DLS to confirm the production, purity, crystalline nature, stability of nanoemulsion, size and shape distribution. The change in 2D and 3D conformation of bromelain after encapsulation was studied by Circular Dichroism and Fluorometry, respectively. It was found that after encapsulation, a 19.4% loss in secondary structure was observed, but tertiary structure was not altered significantly and this loss improved the anticancer activity. The confirmation of bioconjugation of cisplatin with B-GNPs was done by UV-Visible spectroscopy, TEM, FTIR, 2D1H NMR DOSY and ICP-MS. Further, it was found that almost ~4 cisplatin molecules bound with each B-GNPs nanoparticle.
L-type voltage-gated calcium channel regulation of in vitro human cortical neuronal networks
Authors: Plumbly William , Brandon Nick , Deeb Tarek Z. , Hall Jeremy , Harwood Adrian J. 
Published: September 2019

AbstractThe combination of in vitro multi-electrode arrays (MEAs) and the neuronal differentiation of stem cells offers the capability to study human neuronal networks from patient or engineered human cell lines. Here, we use MEA-based assays to probe synaptic function and network interactions of hiPSC-derived neurons. Neuronal network behaviour first emerges at approximately 30 days of culture and is driven by glutamate neurotransmission. Over a further 30 days, inhibitory GABAergic signalling shapes network behaviour into a synchronous regular pattern of burst firing activity and low activity periods. Gene mutations in L-type voltage gated calcium channel subunit genes are strongly implicated as genetic risk factors for the development of schizophrenia and bipolar disorder. We find that, although basal neuronal firing rate is unaffected, there is a dose-dependent effect of L-type voltage gated calcium channel inhibitors on synchronous firing patterns of our hiPSC-derived neural networks. This demonstrates that MEA assays have sufficient sensitivity to detect changes in patterns of neuronal interaction that may arise from hypo-function of psychiatric risk genes. Our study highlights the utility of in vitro MEA based platforms for the study of hiPSC neural network activity and their potential use in novel compound screening.
Nonlinear heart rate variability biomarkers for gastric cancer severity: A pilot study
Authors: Shi Bo , Wang Lili , Yan Chang , Chen Deli , Liu Mulin , Li Peng 
Published: September 2019

AbstractIdentifying prognostic factors by affordable tools is crucial for guiding gastric cancer (GC) treatments especially at earlier stages for timing interventions. The autonomic function that is clinically assessed by heart rate variability (HRV) is involved in tumorigenesis. This pilot study was aimed to examine whether nonlinear indices of HRV can be biomarkers of GC severity. Sixty-one newly-diagnosed GC patients were enrolled. Presurgical serum fibrinogen (FIB), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA199) were examined. Resting electrocardiogram (ECG) of 5-min was collected prior to surgical treatments to enable the HRV analysis. Twelve nonlinear HRV indices covering the irregularity, complexity, asymmetry, and temporal correlation of heartbeat fluctuations were obtained. Increased short-range temporal correlations, decreased asymmetry, and increased irregularity of heartbeat fluctuations were associated with higher FIB level. Increased irregularity and decreased complexity were also associated with higher CEA level. These associations were independent of age, sex, BMI, alcohol consumption, history of diabetes, left ventricular ejection fraction, and anemia. The results support the hypothesis that perturbations in nonlinear dynamical patterns of HRV predict increased GC severity. Replication in larger samples as well as the examination of longitudinal associations of HRV nonlinear features with cancer prognosis/survival are warranted.
Circulating Sphingosine-1-Phosphate as A Non-Invasive Biomarker of Heart Transplant Rejection
Authors: Tarazón Estefanía , Gil-Cayuela Carolina , Manzanares María García , Roca Marta , Lago Francisca , González-Juanatey José Ramón , Sánchez-Lacuesta Elena , Martínez-Dolz Luis , Portolés Manuel , Roselló-Lletí Esther 
Published: September 2019

AbstractAccumulating evidence has confirmed that the expression of sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) is downregulated in heart failure and cardiac allograft rejection. Although many SERCA2a-related genes and proteins involved in the regulation of myocardial Ca2+fluxes have been explored, its related metabolites remain poorly studied. Our main objective was to identify circulating SERCA2a-related metabolites altered in cardiac allograft rejection and to determine whether these could serve as non-invasive biomarkers. Sixty plasma samples from adult heart transplant were included in a metabolomic analysis. Sphingosine-1 phosphate (S1P), metabolite closely related with SERCA, were increased in patients with cardiac rejection (p < 0.0001). S1P discriminated between patients with and without rejection: normal grafts vs. all rejecting grafts (AUC = 0.911, p < 0.0001), normal grafts vs. Grade 1 R (AUC = 0.819, p < 0.01), Grade 2 R (AUC = 0.911, p < 0.0001), Grade 3 R (AUC = 0.996, p < 0.0001). In addition, we found changes in key enzymes and receptors of S1P pathway analysed on explanted hearts from heart failure patients. This preliminary study reveals that circulating S1P determination could be a novel approach to detect cardiac rejection, showing a robust capability for detection that improves gradually with the severity of rejection. These alterations could be relevant to better understand the involvement of calcium regulation on the pathophysiology of rejection.
Extra-axonal restricted diffusion as an in-vivo marker of reactive microglia
Authors: Taquet Maxime , Jankovski Aleksandar , Rensonnet Gaëtan , Jacobs Damien , des Rieux Anne , Macq Benoît , Warfield Simon K. , Scherrer Benoît 
Published: September 2019

AbstractReactive microgliosis is an important pathological component of neuroinflammation and has been implicated in a wide range of brain diseases including brain tumors, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, and schizophrenia. Mapping reactive microglia in-vivo is often performed with PET scanning whose resolution, cost, and availability prevent its widespread use. The advent of diffusion compartment imaging (DCI) to probe tissue microstructure in vivo holds promise to map reactive microglia using MRI scanners. But this potential has never been demonstrated. In this paper, we performed longitudinal DCI in rats that underwent dorsal root axotomy triggering Wallerian degeneration of axons—a pathological process which reliably activates microglia. After the last DCI at 51 days, rats were sacrificed and histology with Iba-1 immunostaining for microglia was performed. The fraction of extra-axonal restricted diffusion from DCI was found to follow the expected temporal dynamics of reactive microgliosis. Furthermore, a strong and significant correlation between this parameter and histological measurement of microglial density was observed. These findings strongly suggest that extra-axonal restricted diffusion is an in-vivo marker of reactive microglia. They pave the way for MRI-based microglial mapping which may be important to characterize the pathogenesis of neurological and psychiatric diseases.