bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arqueologia e educação patrimonial: a experiência do MAE-USP
Authors: Vasconcellos Camilo De Mello 
Published: September 2019

O presente artigo tem a intenção de refletir a respeito do tema da educação patrimonial, levando-se em conta a realidade de atuação do Museu de Arqueologia e Etnologia da Universidade de São Paulo (MAE-USP). Para tal intento, o artigo apresenta algumas questões teórico-metodológicas sobre a relação entre educação patrimonial, a arqueologia e a museologia para, finalmente, na última parte, refletir a respeito de um projeto recém-aprovado de nossa instituição que inclui a utilização dos princípios da educação patrimonial a partir de maquetes táteis de sítios arqueológicos brasileiros.
Monumento Nacional Ruínas Engenho São Jorge dos Erasmos: educação patrimonial e ambiental como chave da preservação
Authors: Ferlini Vera Lucia Amaral , Christofoletti Rodrigo , Jordão Beatriz Pacheco , De Mello André Müller 
Published: September 2019

O uso qualificado de bens culturais e a sua consequente preservação constituem-se em grandes desafios para governos e comunidades neste início de século. As estratégias culturais de salvaguarda dos patrimôniosforam cada vez mais desafiadas pelo jogo plural de uma nova perspectiva histórica. Em nossos dias a reconstituição sistemática de modos de vida de uma época anterior, através de espaços e trocas sociais converte o campo da memória em teatro preferencial de uma busca objetiva de conhecimento. As ruínas do antigo Engenho São Jorge dos Erasmos, monumento nacional dos mais relevantes, atualmente categorizado como museu universitário a céu aberto, constitui complexo arquitetônico único em território brasileiro.Além disso, transformou-se na última década em patrimônio diferenciado, abarcando múltiplos campos de conhecimento. O remanescente do antigo engenho encontra-se em lugar privilegiado, como bem tombado nas instâncias federal (1963), estadual (1974) e municipal (1990). Este texto discute as ações educativas realizadas ao longo dos últimos 15 anos neste espaço e sinaliza os projetos que ajudaram a consolidar sua vocação pedagógica.
Educação e patrimônio na Casa de Dona Yayá: experiências do Centro de Preservação Cultural da USP
Authors: Fernandes Gabriel De Andrade 
Published: September 2019

Este artigo apresenta um panorama da ação educativa desenvolvida pelo Centro de Preservação Cultural (CPC) em sua sede na Casa de Dona Yayá, imóvel tombado em níveis estadual e municipal, localizado no centro do município de São Paulo, na região conhecida como Bixiga. Órgão de cultura e extensão universitária com foco na ação e reflexão sobre o patrimônio cultural da Universidade de São Paulo, o CPC ocupa desde 2004 o imóvel conhecido como “Casa de Dona Yayá”, lugar de memória de questões degênero e saúde mental em função da reclusão vivida por sua mais célebre habitante (Sebastiana Mello Freire, a “Dona Yayá”) durante um período de quatro décadas, bem como testemunho material do processo de urbanização da região em que se encontra. A fim de refletir sobre as possibilidades educativas, dialógicas e de ação cultural próprias tanto de uma instituição voltada à extensão no campo do patrimônio como de um bem patrimonializado marcado pelo acúmulo de diversas camadas de significado e de memória, é apresentado um itinerário crítico das atividades educativas promovidas ao longo de cerca de 15 anos nesse contexto. Discutem-se, tendo por base tais atividades, as potencialidades, limites, desafios e contradições da ação educativa no contexto patrimonial.
Educação patrimonial no Iphan: análise de uma trajetória
Authors: Oliveira Cléo Alves Pinto de 
Published: September 2019

Desde a sua criação, o Iphan manifestou em documentos e publicações a importância da educação patrimonial para a preservação do patrimônio cultural. Contudo, a educação patrimonial foi historicamente tratada como uma atividade complementar às outras realizadas pelo órgão, tendo sido, de modo geral, realizadas atividades pontuais, desvinculadas das ações finalísticas do Iphan. Assim, verifica-se um descompasso entre a importância da educação patrimonial enunciada e as ações realizadas nesse sentido. Frente a esse quadro, este artigo tem como objetivo analisar a trajetória da educação patrimonial no Iphan, contrapondo a enunciação à ação. Espera-se com este trabalho contribuir para a sistematização dessa trajetória, assim como discutir aspectos técnicos e políticos relacionados ao tema, para que as açõesfuturas de educação patrimonial sejam mais efetivas para a preservação do patrimônio cultural.
Política de educação patrimonial no Iphan: diretrizes conceituais e ações estratégicas
Authors: Florêncio Sônia Rampim 
Published: September 2019

Este artigo aborda a construção dos princípios conceituais e diretrizes que pautam a área de educação patrimonial na atuação do Instituto do Patrimônio Histórico e Artístico Nacional (Iphan). Apresenta, também, um panorama histórico com as principais estratégias de ação implementadas nos últimos anos em consonância com essas abordagens. Para tanto, firma a importância de se implementar ações educativas para a preservação do patrimônio que se embasem na construção coletiva do conhecimento e na educação dialógica, nos moldes freireanos. Por fim, apresenta alguns desafios para a contínua construção desse campo de conhecimento e atuação institucional.
Reflexões para ações educativas em conjuntos urbanos tombados: Ouro Preto
Authors: Fernandes Simone Monteiro Silvestre 
Published: September 2019

Este artigo apresenta parte das considerações levantadas pela autora no desenvolvimento de sua dissertação de mestrado no Programa de Mestrado Profissional em Preservação do Patrimônio Cultural do Instituto do Patrimônio Histórico e Artísitico Nacional (Iphan), cujo estudo teve como foco suas inquietações e observações como historiadora, atuando na área educativa do Escritório Técnico de Ouro Preto, do Iphan. Ouro Preto se transformou num lugar repleto de significados, onde a imagem da “cidade colonial” ficou consolidada. A escolha de apenas parte da cidade reflete numa imagem incompleta, dificultando o reconhecimento e o sentimento de pertencimento por parte dos cidadãos, que percebem uma porção de suacidade sendo tratada como monumento e a outra porção sendo esquecida, desconhecida. As informações levantadas sobre as ações desenvolvidas na década de 1980, em Ouro Preto, se refletem nas ações hoje desenvolvidas pela Casa do Patrimônio de Ouro Preto e serão o foco das questões e reflexões levantadas nesse trabalho, pois acreditamos que as cidades podem ser vividas como um bem cultural centrando nossas atenções nas relações sociais e afetivas criadas em torno delas.
Changes in Cardiac Morphology and Function in Individuals With Diabetes Mellitus
Authors: Jensen Magnus T. , Fung Kenneth , Aung Nay , Sanghvi Mihir M. , Chadalavada Sucharitha , Paiva Jose M. , Khanji Mohammed Y. , de Knegt Martina C. , Lukaschuk Elena , Lee Aaron M. , Barutcu Ahmet , Maclean Edd , Carapella Valentina , Cooper Jackie , Young Alistair , Piechnik Stefan K. , Neubauer Stefan , Petersen Steffen E. 
Published: September 2019

Background:
Diabetes mellitus (DM) is associated with increased risk of cardiovascular disease. Detection of early cardiac changes before manifest disease develops is important. We investigated early alterations in cardiac structure and function associated with DM using cardiovascular magnetic resonance imaging.

Methods:
Participants from the UK Biobank Cardiovascular Magnetic Resonance Substudy, a community cohort study, without known cardiovascular disease and left ventricular ejection fraction ≥50% were included. Multivariable linear regression models were performed. The investigators were blinded to DM status.

Results:

A total of 3984 individuals, 45% men, (mean [SD]) age 61.3 (7.5) years, hereof 143 individuals (3.6%) with DM. There was no difference in left ventricular (LV) ejection fraction (DM versus no DM; coefficient [95% CI]: −0.86% [−1.8 to 0.5];
P
=0.065), LV mass (−0.13 g/m
2
[−1.6 to 1.3],
P
=0.86), or right ventricular ejection fraction (−0.23% [−1.2 to 0.8],
P
=0.65). However, both LV and right ventricular volumes were significantly smaller in DM, (LV end-diastolic volume/m
2
: −3.46 mL/m
2
[−5.8 to −1.2],
P
=0.003, right ventricular end-diastolic volume/m
2
: −4.2 mL/m
2
[−6.8 to −1.7],
P
=0.001, LV stroke volume/m
2
: −3.0 mL/m
2
[−4.5 to −1.5],
P
<0.001; right ventricular stroke volume/m
2
: −3.8 mL/m
2
[−6.5 to −1.1],
P
=0.005), LV mass/volume: 0.026 (0.01 to 0.04) g/mL,
P
=0.006. Both left atrial and right atrial emptying fraction were lower in DM (right atrial emptying fraction: −6.2% [−10.2 to −2.1],
P
=0.003; left atrial emptying fraction:−3.5% [−6.9 to −0.1],
P
=0.043). LV global circumferential strain was impaired in DM (coefficient [95% CI]: 0.38% [0.01 to 0.7],
P
=0.045).

Conclusions:
In a low-risk general population without known cardiovascular disease and with preserved LV ejection fraction, DM is associated with early changes in all 4 cardiac chambers. These findings suggest that diabetic cardiomyopathy is not a regional condition of the LV but affects the heart globally.
Leading with a Fist: A History of the Salafi Beard in the 20th-Century Middle East
Authors: Rock-Singer Aaron 
Published: September 2019

Abstract
Salafism is a global religious movement whose male participants often distinguish themselves from their co-religionists by a particular style of facial hair. Historians have focused largely on this movement’s engagement with questions of theology and politics, while anthropologists have assumed that Salafi practice reflects a longer Islamic tradition. In this article, I move beyond both approaches by tracing the gradual formation of a distinctly Salafi beard in the 20th century Middle East. Drawing on Salafi scholarly compendia, leading journals, popular pamphlets, and daily newspapers produced primarily in Egypt and Saudi Arabia, I argue that Salafi elites revived a longer Islamic legal tradition in order to distinguish their flock from secular nationalist projects of communal identity and Islamic activists alike. In doing so, I cast light on Salafism’s interpretative approach, the dynamics that define its development as a social movement, and the broader significance of visual markers in modern projects of Islamic piety.
Longitudinal analysis of brain atrophy in Alzheimer’s disease and frontotemporal dementia
Authors: Marino Silvia , Bonanno Lilla , Lo Buono Viviana , Ciurleo Rosella , Corallo Francesco , Morabito Rosa , Chirico Gaetano , Marra Angela , Bramanti Placido 
Published: September 2019

Objectives Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are among the leading causes of early-onset dementia. This study aimed to assess the rate of whole brain atrophy by comparing bvFTD and AD. Methods Two patients (one man with AD, and one woman with bvFTD) had neuropsychological and neuroimaging assessment by using automated techniques for cross-sectional and longitudinal atrophy measurements. Results In the patient with AD, magnetic resonance imaging (MRI) showed decreased bilateral hippocampal and mesial-temporal volume. However, conventional images showed no difference between baseline (T0) and after 1 year (T1). In the patient with bvFTD, MRI showed bilateral frontotemporal lobe atrophy and a moderate increase in atrophy between T0 and T1, particularly in the temporal lobes. A cross-sectional cerebral volume examination showed a considerable reduction in brain volume in the patient with bvFDT and a moderate reduction in the patient with AD. A longitudinal cerebral volume examination showed a lower percentage brain volume change in the patient with bvFTS compared with the patient with AD. Conclusions Our results suggest that bvFTD has more neurodegenerative progression. MRI findings should be considered as a reliable marker of disease progression in the brain. Our findings offer potential for monitoring treatment outcomes.
Cerebrospinal fluid biomarkers and cognitive status in differential diagnosis of frontotemporal dementia and Alzheimer’s disease
Authors: Casoli Tiziana , Paolini Susy , Fabbietti Paolo , Fattoretti Patrizia , Paciaroni Lucia , Fabi Katia , Gobbi Beatrice , Galeazzi Roberta , Rossi Roberto , Lattanzio Fabrizia , Pelliccioni Giuseppe 
Published: September 2019

Objective This study aimed to determine the most appropriate cognitive and cerebrospinal fluid (CSF) biomarker setting to distinguish frontotemporal dementia (FTD) from Alzheimer’s disease (AD). Method Patients with FTD, those with AD, and those without dementia were enrolled in this study. CSF amyloid-ß 42 (Aß42), total (t)-tau, and phosphorylated (p)-tau concentrations were determined by enzyme-linked immunosorbent assays. Cognition was evaluated by the Mini-Mental State Examination (MMSE) and its domain scores. The associations of CSF biomarkers with cognitive measures were examined using regression models and the diagnostic value of CSF biomarkers was determined by receiver operating characteristics curves. Results CSF Aß42 levels were lower, whereas t-tau/Aß42 and p-tau/Aß42 ratios were higher in patients with AD compared with those with FTD. Some MMSE domain scores were different in FTD and AD, but they did not improve the ability to distinguish between the two pathologies. Poor temporal orientation scores were associated with low Aß42 levels only in patients with FTD. The p-tau/Aß42 ratio reached sufficient levels of sensitivity and specificity to discriminate FTD with primary progressive aphasia from AD. Conclusions The ratio of CSF p-tau/Aß42 is a sensitive and specific biomarker for discriminating patients with primary progressive aphasia from those with AD.
Monitoring chronic headache and medication-overuse headache prevalence in Denmark
Authors: Westergaard Maria Lurenda , Lau Cathrine Juel , Allesøe Karen , Gjendal Signe Thorup , Jensen Rigmor Højland 
Published: September 2019

Objectives To study chronic headache and medication-overuse headache (MOH) prevalence; to identify groups with high prevalence of these conditions; and to identify the most frequently used pain medications among respondents with chronic headache. Background Chronic headache and MOH prevalence in Denmark were last estimated in 2010. Methods In this cross-sectional study, 104,950 individuals aged ≥16 years were randomly sampled for the 2017 Danish Capital Region Health Survey. Responses to questions about headache and use of acute pain medications were linked to demographic registries. MOH was defined as headache ≥15 days/month plus self-report of use of pain medications ≥10 or 15 days/month, in the last three months. Weighted prevalence proportions were calculated. Results Among 55,185 respondents, chronic headache prevalence was 3.0% (95% CI: 2.3–3.2) and MOH prevalence was 2.0% (95% CI: 1.8–2.1). Both conditions were more common among females and the middle-aged. Respondents on social welfare or receiving early retirement pensions had the highest prevalences. Among those with chronic headache, 44.7% overused over-the-counter analgesics for headache; paracetamol 41.5%; a combination of different pain relievers 25.3%; ibuprofen 21.9%; opioids 17.0%; combination preparations 14.3%; and triptans 9.1%. Conclusions The highest prevalence of chronic headache and MOH was seen among people with low socioeconomic position. Overuse of paracetamol was most common. Reported opioid use was higher than expected. Groups with high prevalence of MOH should be the focus of public health interventions on rational use of OTC and prescription pain medications.
Evaluation of Congenital Maxillary Growth Using Computed Tomography in Patients With Bilateral Cleft Lip and Palate
Authors: Kobayashi Shinji , Yasumura Kazunori , Hirakawa Takashi , Fukawa Toshihiko , Maegawa Jiro 
Published: September 2019

Objective: To analyze congenital lateral maxillary growth for patients with bilateral cleft lip and palate (BCLP). Design: A retrospective study. Setting: Kanagawa Children’s Medical Center. Materials: Images from computed tomography (CT) of patients with BCLP and control patients that were previously used for treatment. Main Outcome Measures: The following landmarks were used: A, the posterior most point of the piriform aperture; B, the superior most point of the acoustic meatus; C, the point at which line A-B intersects the line drawn perpendicular from line A-B to the maxillary tuberosity; and D, the apical most point of the nasal bone. The following distances were then measured using these landmarks: (1) A-B distance; (2) A-C distance; (3) A-C/A-B; (4) the angle between lines A-B and A-D (∠BAD); and (5) B-D distance. Result: Mean A-B and A-C distances and A-C/A-B were significantly smaller in the BCLP group than in the control group ( P < .01 each). Mean ∠BAD was significantly larger in the BCLP group than in the control group ( P < .01). Mean B-D distance did not differ significantly between groups. Conclusions: Our results indicated that the lateral maxillary segments of patients with BCLP were more posterior than those of the control group, and segment length was shorter compared to the control group on 3D-CT analysis. The lateral maxillary segments of patients with BCLP were basically suggested to originally be underdeveloped.
Prognostic Value of mRNA Expression of MAP4K Family in Acute Myeloid Leukemia
Authors: Bai Zhenjie , Yao Qingmei , Sun Zhongyi , Xu Fang , Zhou Jicheng 
Published: September 2019

Background: Despite diverse functions in diseases, the prognostic potential of the family of mitogen-activated protein kinase kinase kinase kinase genes in acute myeloid leukemia remains unknown. Methods: The messenger RNA expression of the MAP4K family members in 151 patients with acute myeloid leukemia was extracted from the OncoLnc database. Data for gender, age, cytogenetic, leukocyte count, CD34, FAB classification, RUNX1, and TP53 were provided by the University of California–Santa Cruz Xena platform. Kaplan-Meier analysis and Cox regression model provided an estimate of the hazard ratio with 95% confidence intervals for overall survival. Results: Analysis demonstrated favorable overall survival in patients with acute myeloid leukemia attributing to high expression of MAP4K3, MAP4K4, and MAP4K5 and low expression of MAP4K1 (adjusted P = .005, P = .022, P = .002, and P = .024; adjusted hazard ratio = 0.490, 95% confidence interval = 0.297-0.809, hazard ratio = 0.598, 95% confidence interval = 0.385-0.928, hazard ratio = 0.490, 95% confidence interval = 0.310-0.776, and hazard ratio = 0.615, 95% confidence interval = 0.403-0.938, respectively). Combining the high-expressing MAP4K3, MAP4K4, and MAP4K5 with the low-expressing MAP4K1 in a joint effect analysis predicted a favorable prognosis of overall survival in acute myeloid leukemia. Conclusion: High expression of MAP4K3, MAP4K4, and MAP4K5 combined with low expression of MAP4K1 can serve as a sensitive tool to predict favorable overall survival in patients with acute myeloid leukemia.
Genetic characterization of B-cell prolymphocytic leukemia: a prognostic model involving MYC and TP53
Authors: Chapiro Elise , Pramil Elodie , Diop M'boyba , Roos-Weil Damien , Dillard Clémentine , Gabillaud Clémentine , Maloum Karim , Settegrana Catherine , Baseggio Lucile , Lesesve Jean-François , Yon Mélanie , Jondreville Ludovic , Lesty Claude , Davi Frederic B , Le Garff-Tavernier Magali , Droin Nathalie M , DESSEN Philippe , Algrin Caroline , Leblond Veronique , Gabarre Jean , Bouzy Simon , eclache virginie , Gaillard Baptiste , Callet-Bauchu Evelyne , Muller Marc , LEFEBVRE Christine , NADAL Nathalie , Ittel Antoine , Struski Stephanie , Collonge-Rame Marie-Agnès , QUILICHINI BENOIT , Fert-Ferrer Sandra , Auger Nathalie , Radford-Weiss Isabelle , Wagner Lena , Scheinost Sebastian , Zenz Thorsten , Susin Santos A. , Bernard Olivier A , Nguyen-Khac Florence 
Published: September 2019

Key Points
B-PLL is tightly linked to MYC aberrations (translocation or gain) and 17p (TP53) deletion. Cases of B-PLL with MYC aberration and 17p (TP53) deletion have the worst prognosis.
Protoporphyrin IX-loaded laminarin nanoparticles for anticancer treatment, their cellular behavior, ROS detection, and animal studies
Authors: Yu Yueming , Wang Bingjie , Guo Chunjing , Zhao Feng , Chen Daquan 
Published: September 2019

Abstract
Laminarin conjugate-based nano-scaled particles were in this study proposed as a delivery system for protoporphyrin IX (Pp IX) in photodynamic therapy (PDT) of human breast cancer cells (MCF-7). Hematin-Laminarin-Dithiodipropionic Acid-MGK, named as HLDM, was an amphiphilic carrier material with dual pH/redox sensitive that could be used to load hydrophobic drug to improve their solubility and enhance biocompatibility. Therefore, we combined photosensitizer (Pp IX) with HLDM to fabricate a novel nano-micelles, herein called Pp IX-loaded HLDM micelles. The Pp IX-loaded HLDM micelles were 149.3 ± 35 nm sized in neutral water. Phototoxicity, in vitro PDT effect, and dual sensibility to pH and redox microenvironment of Pp IX-loaded HLDM micelles were examined at different concentrations by using MCF-7 human breast cancer cells. The experiments on phototoxicity and reactive oxygen species (ROS) production proved that the micelles could produce PDT to kill the cancer cells with a certain wavelength light. The apoptosis experiment indicated that the micelles could cause nuclear damage. In vivo PDT effect of the micelles was studied by constructing the tumor-bearing nude mouse model of MCF-7 cells. In vivo studies showed that the Pp IX-loaded HLDM micelles could induce remarkable anti-tumor effect. A promising laminarin-based nanomedicine platform acts as a new drug delivery system to enhance the uptake, accumulation, and PDT efficacy of Pp IX in vitro and in vivo.
Impact of age on the seasonal prevalence of hypernatremia in the emergency department: a single-center study
Authors: Imai Naohiko , Sumi Hirofumi , Shibagaki Yugo 
Published: September 2019

Abstract

Background
Hypernatremia is one of the most commonly encountered electrolyte disorders in the emergency department (ED). Few studies have reported the seasonal fluctuations of the prevalence of hypernatremia with conflicting results. We investigated the seasonal prevalence of hypernatremia in an emergency department in Japan.

Methods
A total of 12,598 patients presented to the ED between January 2015 and December 2017 were reviewed. The adult group aged between 18 and 64 years old consisted of 5427 patients and the elderly group aged over 65 years consisted of 7171 patients. Information collected included age, sex, serum sodium, and serum creatinine. Hypernatremia was defined as a serum sodium leve1 > 145 mEq/L, and moderate to severe hypernatremia was defined as a serum sodium level ≥ 150 mEq/L.

Results
The prevalence of hypernatremia was significantly higher in the elderly group than in the adult group (2.6% vs. 0.7%; p < 0.001). Similarly, the prevalence of moderate to severe hypernatremia was significantly higher in the elderly group than in the adult group (1.0% vs. 0.1%; p < 0.001). The prevalence of hypernatremia and moderate to severe hypernatremia was significantly higher in the elderly group than in the adult group in all seasons. In the elderly group, the seasonal prevalence of moderate to severe hypernatremia was significantly higher during the winter. Also, there was a correlation between weather temperature and the prevalence of moderate to severe hypernatremia in the elderly group (r = − 0.34, p = 0.04).

Conclusions
Hypernatremia is prevalent in the elderly and the prevalence is highest during the winter. Special attention should be paid in the elderly patients to prevent hypernatremia especially in the winter.