bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFFECTIVENESS OF MAINTENANCE THERAPY AFTER THE END OF THE FIRST LINE OF TREATMENT FOR PATIENTS WITH METASTATIC COLORECTAL CANCER – THE RESULTS OF A POPULATION-BASED STUDY
Authors: Fedyanin M. Yu. , Aliyeva Sh. A. , Vladimirova L. Y. , Ivanov A. N. , Katkov A. A. , Kuzmina E. S. , Kulik V. V. , Matyushina E. I. , Nikitina L. Yu. , Orlova R. V. , Povyshev A. Yu. , Pshevlotskiy E. M. , Ramazanova M. S. , Smirnova E. V. , Tkachuk A. D. , Ulanova N. V. , Shalofast O. V. , Erdniev S. P. , Tjulandin S. A. 
Published: November 2018

Aim.To evaluate the effectiveness of different regimens of maintenance chemotherapy after the first line of treatment for patients with metastatic colorectal cancer.Materials and methods.We performed retrospective analyses of the data from 432 patients from 17 clinics in 14 regions of the Russian Federation who started systemic therapy for metastatic cancer in 2013. The main inclusion criterion was objective response or stabilization after the first 16 weeks of first-line therapy. Four groups of patients were compared, depending on the nature of maintenance therapy: those receiving fluoropyrimidines, a combination of fluoropyrimidines with bevacizumab, monotherapy of bevacizumab and monotherapy of anti-EGFR antibodies. The main criteria for assesment of the effectiveness of treatment were progression-free survival and overall survival. The statistical analysis was performed with the SPSS 20.0 sof tware package.Results.Maintenance therapy after completion of the first 16 weeks of the 1st line of chemotherapy was administered in 126 patients, most of them were treated with fluoropyrimidines (53.1 %). The median overall survival in the maintenance group was 27 versus 21 months in the observation group, p=0.01, HR=0.78 (95 % CI 0.6–1.02) Median progression-free survival in the maintenance group was 11 vs 7 months in the observation group (p<0.001, HR=0.6, 95 % CI 0.5–0.8). The worst results of progression-free survival were observed in the group with monotherapy of bevacizumab – median was 10 months versus 12 months in the fluoropyrimidine monotherapy group, 10 months for the combination of fluoropyrimidine with bevacizumab and 14 months for monotherapy of the anti-EGFR (p=0,9, HR=1.0, 95 % CI 0.9–1.2).Conclusions.There were no statistical differences in survival with different regimens of maintenance therapy. Monotherapy of bevacizumab in maintenance treatment was associated with the worst sur vival rates.
1 NUMARALI TRABZON AHKÂM DEFTERİ’NDE KÜRTÜN NAHİYESİ İLE İLGİLİ KAYITLAR (1742-1759)
Authors: GÖKÇEK Mehmet Fatih 
Published: November 2018

Divan-ı hümayun, Osmanlı
Devleti'nin en üst idarî ve yargı birimiydi. Divan'da müzakere edilerek karara
bağlanan meseleler çeşitli defter serilerine yazılırdı. Bu defter serilerinden
biri de 1742'de ortaya çıkan Eyalet Ahkâm defterleridir. Eyalet Ahkâm
defterleri, merkeze intikal eden şikâyetleri ve mahallî mahkemelerde halledilemeyen
davalara ilişkin merkezî idarenin getirdiği çözümleri içerir. Bu bakımdan
Eyalet Ahkâm defterleri yerel tarih araştırmacıları için temel başvuru
kaynaklarındandır. Çalışmada 1742-1759 yılları arasındaki hükümleri ihtiva eden
1 Nolu Trabzon Ahkâm Defteri ele alınarak merkezden Kürtün'e
gönderilen hükümler değerlendirilmiş ve bu hükümlerden hareketle Kürtün'ün
idarî, sosyal ve ekonomik tarihine ilişkin bilgiler verilmiştir.
I. DÜNYA HARBİ'NDE "ARTVİN'İN NENE HATUN'U": ÇİÇEK NENE
Authors: GÜVEN Onur 
Published: November 2018

"40 yıllık kara
günler" olarak isimlendirilen Rus esareti döneminde (93 Harbi-I. Dünya
Harbi arası) Artvin halkı çeşitli sıkıntılara ve acılara katlanarak, büyük
fedakârlıklarda bulunmuştur. Büyük göçe maruz kalan halk yerini, yurdunu
kaybetmiştir. Artvin ve çevresinde Rus saldırılarının yoğun olduğu 1915
yılında, gönüllü birlikler tarafından savunulan Şavşat'ta büyük bir direniş
olmuştur.&nbsp; Rus kuvvetler ve milis güçler
arasında şiddetli çatışmalar sürerken Çiçek Nene'nin cesurca ve kahramanca
mücadelesi, önemli bir direniş figürü olarak karşımıza çıkar. Türk kadınının
yeri geldiğinde cephe arkasında, yeri geldiğinde cephede gösterdiği destansı
faaliyetler herkesin malumudur ve savaş esnasındaki mücadelesi paha
biçilemezdir. Bunun bir örneğini Çiçek Nene aracılığıyla Artvin'de görmek
mümkündür.
TRABZON İMPARATORLUĞU’NUN KURULUŞU (1204-1222)
Authors: KEÇİŞ Murat , HANAR Murat 
Published: November 2018

Bu
makalede; İstanbul’un IV. Haçlı Seferleri sırasında Latinler tarafından istila
edilmesi üzerine şehri terk eden hanedan ailelerinden Komnenosların 1204
yılında Trabzon’da kurdukları ve 1461 yılında Fatih Sultan Mehmet’in fethi ile
sona eren Trabzon Rum Devleti’nin kuruluş evresi anlatılmaktadır.
Interpolation Using Cubic Bѐzier Triangular Patches
Authors: Abdul Karim Samsul Ariffin , Saaban Azizan , Hasan Mohammad Khatim , Sulaiman Jumat , Hashim Ishak 
Published: November 2018

Spatial interpolation is a method that can be used to estimate the unknown value (or parameter) at certain time or location. Besides of that, shape preserving interpolation especially positivity preserving interpolation play an important role for data visualization where the resulting interpolating surface must be positive everywhere. In this study, we use a triangulation based method consists of positivity preserving cubic Bí©zier triangular patches to estimate the unknown value of rainfall amount at spatial localization. This scheme is useful for spatial data interpolation compared to the mesh free methods which are required the optimization technique in order to ensure the positivity of basis functions.The data is triangulated by using Delaunay’s triangulation algorithm and from there the triangular surfaces are constructed piecewisely comprising three local schemes that are blended together via convex combination to form a scattered interpolating surface. Sufficient conditions on Bí©zier ordinates are derived in order to preserve the positivity of the surface. Validation of the propose schemes are conducted by using well-known test function used in previous researches. Then, the best the scheme is selected to visualize a rainfall data distribution based on secondary data collected at various meteorology stations in Malaysia obtain from Malaysian Meteorology Department. Finally, we estimate the unknown rainfall amount at certain locations that lies inside the convex hull formed by all given stations. The finding shows that positivity preserving cubic triangular patches is able to preserve the positivity of rainfall distribution surface and has a significant application in estimating the rainfall amount at unallocated meteorology stations in Malaysia.
Feature selection from colon cancer dataset for cancer classification using Artificial Neural Network
Authors: Rahman Md. Akizur , Muniyandi Ravie Chandren 
Published: November 2018

In the fast-growing field of medicine and its dynamic demand in research, a study that proves significant improvement to healthcare seems imperative especially when it is on cancer research. This research paved way to such significant findings by the inclusion of feature selection as one of its major components. Feature selection has become a vital task to apply data mining algorithms effectively in the real-world problems for classification. Feature selection has been the focus of interest for quite some time and much completed work related to it. Although much research conducted on the field, a study that proved a nearly perfect accuracy seems limited; hence, more scientifically driven results should be produced. Using various research on feature selection as basis for the choices in this study, the method was product of careful selection and planning. Specifically, this study used feature selection for improving classification accuracy on cancerous dataset. This study proposed Artificial Neural Network (ANN) for cancer classification with feature selection on colon cancer dataset. The study used best first search method in weka tools for feature selection. Through the process, a promising result has been achieved. The result of the experiment achieved 98.4 % accuracy for cancer classification after feature selection by using proposed algorithm. The result displayed that feature selection improved the classification accuracy based on the experiment conducted on the colon cancer dataset. The result of this experiment was comparable with the other studies on colon cancer research. It showed another significant improvement and can be considered promising for more future applications.
Primary and Secondary School Students Perspective on Kolb-based STEM Module and Robotic Prototype
Authors: Zainal Noor Faridatul Ainun , Din Rosseni , Abd Majid Nazatul Aini , Nasrudin Mohammad Faidzul , Abd Rahman Abdul Hadi 
Published: November 2018

The aim of this paper is to assess students' perceptions of their competency and interests in Science, Technology, Engineering and Mathematics (STEM) throughout Malaysia. These perceptions are obtained during and after they were engaged in using a STEM module and building a robotic prototype that was in line with the STEM teachers' specification, and was conducted at the National Science Centre, Malaysia. This activity was undertaken because the target ratio for the number of students enrolling in STEM programs is not met. The developed STEM module is based on four stages of the learning cycle in Kolb's experiential learning theory. The stages are Concrete Experience, Reflective Observation, Abstract Conceptualization, and Active Experimentation. These stages have five key educational activities which are watching videos, reading modules, assembling robotic components, drag and drop using blockly software and lastly playing a robotic game. The key element of the activities is the utilisation of a robotic prototype as the main component in increasing the students’ interest in STEM via games. This module was evaluated in both qualitative and quantitative case studies of students to inform teachers’ perceptions of the developed modules and robotic prototypes. Data were collected through two training events at a science exhibition at the National Science Centre and taken from two distinct groups, namely primary and secondary school students in range 11 to 15 year old. The evaluation comprised of five areas which were interaction, engagement, challenge, competency and interest. The results show that developed module and robotic prototype based n teacher’s perception received positive response from the respondents. It can efficiently raise students’ interest in STEM that meets the Malaysia Education Blueprint 2013-2025.
Enhanced Buffer Management Policy and Packet Prioritization for Wireless Sensor Network
Authors: Rabileh Abdiwahab A , Abu Bakar Khairul Azmi , Mohamed Rajina R , Mohamad Mohamad A 
Published: November 2018

Limited storage of the sensor node is one of the main causes of packet drop in the Wireless sensor network (WSN). Frequent link disconnection is also another cause of packet drop. Due to lack of continues end-to-end connection; two nodes may not be able to communicate with one another. Thus, communication may be established with the help of store and forward approach between the source and destination node. In that case, the sensor node may not be capable of storing a chunk of data since the buffer is available in a small amount. In order to store the data packets in the buffer when the link is down, an effective buffer management scheme is highly needed to keep the data packets for a long time until the link is re-established. This paper proposes a new buffer management scheme called Packet Priority Heterogonous Queue (PPHQ), which based on prioritizing and classifying the packets into different categories to minimize the loss of important packets. Unlike the existing Multi-layer WSN, that treats the data packets differently; we considered the data packets such as; temperature, humidity, and pressure to be same. However, the classification of different packet types is based on the sensor’s information value. We completely divide the whole buffer into different queues, and thus the newly arrived packets are inserted in their corresponding queue. The buffer will then prioritize and schedule on which packet to be stored or transmit first when the buffer is overloaded. Our result exhibits that PPHQ scheme indeed provides minimum packet drop as well as maximum throughput compared to existing Multi-layer WSN buffer management schemes.
Image Enhancement Background for High Damage Malay Manuscripts using Adaptive Threshold Binarization
Authors: Yahya Sitti Rachmawati , Omar Khairuddin , Sheikh Abdullah Siti Norul Huda , Sophian Ali 
Published: November 2018

Jawi Manuscripts handwritten which are kept at Malaysia National Library (MNL), has aged over decades. Regardless of the intensive sustainable process conducted by MNL, these manuscripts are still not maintained in good quality, and neither can easily be read nor better view. Even thought, many states of the art methods have developed for image enhancement, none of them can solve extremely bad quality manuscripts. The quality of old Malay Manuscripts can be categorize into three types, namely: the background image is uneven, image effects and image effects expand patch. The aim of this paper is to discuss the methods used to value add the quality of the manuscript. Our propose methods consist of several main methods, such as: Local Adaptive Equalization, Image Intensity Values, Automatic Threshold PP, and Adaptive Threshold Filtering. This paper is intend to achieve a better view image that geared to ease reading. Error Bit Phase achievement (TKB) has a smaller error value for proposed method (Adaptive Threshold Filtering Process / PAM) namely 0.0316 compared with Otsu’s Threshold Method / MNAO, Binary Threshold Value Method / MNAP, and Automatic Local Threshold Value Method / MNATA. The precision achievement (namely on ink bleed images) is using a proposed method more than 95% is compared with the state of the art methods MNAO, MNAP, MNATA and their performances are 75.82%, 90.68%, and 91.2% subsequently. However, this paper’s achievement is using a proposed method / PAM, MNAO, MNAP, and MNATA for correspondingly the image of ink bleed case are 45.74%, 54.80%, 53.23% and 46.02%. Conclusion, the proposed method produces a better character shape in comparison to other methods.
Profiling of Wavelength Biomarkers of Pure Meat Samples from Different Species Based on Fourier Transform Infrared Spectroscopy (FTIR) and PCA Techniques
Authors: Saputra Irwan , Jaswir Irwandi , Akmeliawati Rini 
Published: November 2018

Infrared spectroscopy (IR) has been known as an analytical method suitable for authenticity studies. In particular, Fourier transform infrared (FTIR) spectroscopy can be used for qualitative and quantitative purposes. The main advantages of FTIR are high sensitivity, high energy throughput and excellent speed of spectral acquisition. Combined with computer and advanced chemometric software, FTIR can easily be used to manipulate spectral information. Biomarkers such as DNA/RNA, proteins, metabolites, or a combination of profiles of several of these molecules are indicators that may be used to rapidly and easily detect the status and phase of biological processes. Thus biomarkers provide information about the status and phase of biological processes and their underlying particular traits. This study aims to investigate pig wavelength biomarkers against other pure samples of different types of meat based on Fourier Transform Infrared Spectroscopy (FTIR) and PCA techniques. Fat from four different animal meats (pig,chicken,beef, and lamb) were processed under different extraction conditions prior to FTIR and PCA analysis. Palm oil was used as control. Sixteen wavelenghts in accordance to type of fat and processing method were identified as spectral markers to differentiate pig, beef, lamb, and chicken fats, and palm oil. The spectral biomarkers identifying pig and chicken fats were quite similar, complicating the identification of samples containing said fats. The biomarker wavelengths identified from the spectra of the four fats and palm oil at position 1236 and 3007 cm-1 separated the four animal fats and palm oil at notable distances, indicating that these wavelength could be used to identify non-halal samples.
Carotenoid and Chlorophyll Profiles in Five Species of Malaysian Seaweed as Potential Halal Active Pharmaceutical Ingredient (API)
Authors: R Othman , N.A Amin , M.S.A Sani , N.A Fadzillah , M. A Jamaludin 
Published: November 2018

Seaweed, also known as macroalgae, consist of various species that have been gaining the interest of researchers due to the presence of functional bioactive compounds that can be extracted from their biomass. This research aimed to study the chlorophyll and carotenoid content from five species of Malaysian seaweed as potential Active Pharmaceutical Ingredient (API). Three species of red macroalgae, (Eucheuma denticulatum, Gracilaria tikvahiae, and Kappaphycus striatum), green macroalgae (Caulerpa lentillifera ) and one brown macroalga (Padina pavonica) were selected and their chlorophyll and carotenoid contents were determined by using UV-Vis spectrophotometer and HPLC. Their antioxidant and antimicrobial activities were investigated using DPPH Radical Scavenging activity and Disc Diffusion methods, respectively. In terms of carotenoid content, P. pavonica contained the highest amount of carotenoid (100.9 ± 14.7 ug/g DW) and chlorophyll content (7.5 ±1.5 ug/g DW). Meanwhile, based on individual carotenoid content, K. striatum had the highest lutein content (38.6 ug/g DW). Zeaxanthin, beta-carotene, and violaxanthin were significantly higher in C. lentillifera at 21.3 ug/g DW, 10.7 ug/g DW, and 8.9 ug/g DW respectively. Besides that, the antioxidant test showed that P. pavonica presented the strongest DPPH activity with the percentage of inhibition (I %) of (61.0 % ± 0.9). Finally, for the antimicrobial test, strong antimicrobial activities were shown by all the seaweed samples toward E. coli and P. aerugenosa. Overall results of the antifungal test demonstrated moderate antifungal action by all seaweed samples towards M. gypseum and Fusarium sp.
Auto Halal Detection Products Based on Euclidian Distance and Cosine Similarity
Authors: Rakhmawati Nur Aini , Firmansyah Azmi Adi , Effendi Pradita Maulidya , Abdillah Rosyid , Cahyono Taufiq Agung 
Published: November 2018

Although Indonesia is the world the world's most populous Muslim-majority country, the number of halal-certified products in Indonesia is only 20% of the products on the Indonesian market. Halal certification is voluntary as such there are many food products which are halal but are not certified as halal. In principle, these food products may have similar halal ingredients with halal-certified products. In this study, we build a system that can compare products that have not been certified halal with halal certified products based on its ingredients. The food products are collected from Open Food Facts, Institute For Foods, Drugs, And Cosmetics Indonesian Council Of Ulama (LPPOM MUI) and our halal system. As of this paper writing, the halal-certified products are obtained from LPPOM MUI. The system uses the Euclidean Distance and Cosine Similarity that generate top-5 similar products. Those two similarity calculations are based on Term Frequency-Inverse Entity Frequency weighting function. The weighting function calculates the frequency of a term on a product name and ingredients. If a similarity value of a product with no halal certification and a halal-certified product is higher than 75%, then the former could be indicated as a halal product. In the end, the system can give a recommendation of unknown products from a related pool of halal-certified products based on similarity of product composition. Cosine similarity accuracy is higher than Euclidean Distance and MoreLikeThis accuracy. Cosine similarity gets the highest precision because the cosine similarity is based on the vector angle of the term in a product.
The Role of Powder Sub-bituminous Coal with Sodium Hydroxide (NaOH) to Improve Chemical Properties of Ultisols
Authors: Herviyanti Herviyanti , Prasetyo T.B. , Juniarti Juniarti , Prima S. , Wahyuni S. 
Published: November 2018

This research was conducted in soil chemical laboratory, Faculty of Agriculture, Andalas University, from December 2016 until May 2017. The purpose of this research are to determine the level of activeness of powder coal Sub-bituminouscoalwith Sodium Hydroxide (NaOH) and to determine the appropriate dosage of the mixture in improving the chemical properties of Ultisols. This research was conducted in 2 stages: first stage study with 10 treatments (1% to 10% (w/w) NaOH) and the second stage study on soil using 15 treatment combinations (3 doses of powder sub-bituminous coal with 5 doses of NaOH). The results of the first stage of research is the addition of NaOH in Sub-bituminous to increase the activity of powder Sub-bituminous coalwith parameters of pH, CEC, and increases the number of O-H, C=O, and CH3 groups.The results of stage II studies is the provision of a mixture of 20 ton(ha)-1powder Sub-bituminous coaland 10% of NaOH were able to increases the pH of H2O, CEC, organic-C, Available-P, and Total-N Ultisol each of 1.49 units, 28.08 me.100g-1, 1.63 % C, 2.37 ppm P, 0.06% N, and decreases Al-exch Ultisol by 1.17 me.100g-1and , SAR Ultisol by 0.03, and ESP Ultisols by 0.82 %compared to nature soil.
Contextualización del modelo de gestión de la Puerta del Sol (Madrid)
Authors: Cuenca Gonzaga Marlown 
Published: November 2018

Este trabajo de investigación recoge los resultados del estudio de patrones de observación de la Puerta del Sol en el mes de junio 2014, así como un análisis del uso y la gestión que se ejecuta en ella. También se analiza la ocupación física del 15-M como gestión alternativa del espacio público. Los resultados muestran que, de acuerdo a las relaciones obvias, físicas, medioambientales y de producción social, el espacio esta subutilizado. En el presente trabajo se aplica la interpretación del método utilizado por Matthew Carmona en “Public Space” para definir el carácter del espacio público, limitando la investigación hasta este punto. Los resultados evidencian la necesidad de una nueva gestión más incluyente y diversa, así como de usos que reclaman “el derecho a la ciudad”.
En los límites de la ciudad: El caso de la Cañada Real Galiana de Madrid
Authors: Morado Castresana Candela 
Published: November 2018

ResumenCon esta investigación pretendemos estudiar la formación de territorios fronterizos en tanto que límites físicos y simbólicos de las ciudades a través del análisis de un caso concreto: La Cañada Real Galiana, que ejemplifica el límite este-sur de la ciudad de Madrid, pero también el límite de lo urbano y lo civilizado con un espacio sin ley ni orden. Para ello, tomaremos en cuenta diferentes escalas, considerándolas como perspectivas de análisis: escala legal y morfo-tipológica, escala mediática y la escala del discurso encarnado. Analizar la articulación de estas tres dimensiones nos permitirá comprender cómo se conforman políticas públicas, planes urbanos o imaginarios colectivos, desvelando la Cañada Real como un objeto múltiple, complejo y controvertido.Palabras clave Ciudad informal, imaginarios colectivos, estigmatización territorial, desigualdad urbanaAbstractThe aim of this research is to explore the formation of city border areas in terms of physical and symbolic boundaries through the specific case study of La Cañada Real Galiana. This territory exemplifies both the south-east limit of the city of Madrid and the frontiers between civilised urbanisation and a space with no law and order. In order to do so, this research analyses three different fields: legal and morphotypological issues, media representation, and discourse. Analysing the articulation of these three aspects permit the evaluation of how public politics, urban designs and the collective imaginary are conformed. Through this process, La Cañada Real is revealed as a multiple, complex and controversial object.KeywordsInformal city, collective imaginary, territorial stigmatization, urban inequality