bluuebunny/crossref_metadata_2025_split huggingface dataset:
A role for onomatopoeia in early language: evidence from phonological development
Authors: LAING CATHERINE 
Published: January 2019

abstractOnomatopoeia appear in high quantities in many infants’ earliest words, yet there is minimal research in this area. Instead, findings from the wider iconicity literature are generalised to include onomatopoeia, leading to the assumption that their iconic status makes them inherently learnable, thereby prompting their early production. In this review we bring together the literature on onomatopoeia specifically and iconicity more generally to consider infants’ acquisition from three perspectives: perception, production, and interaction. We consider these findings in relation to Imai and Kita’s (2014) ‘sound symbolism bootstrapping hypothesis’ to determine whether their framework can account for onomatopoeia alongside other iconic forms.
The braid index of reduced alternating links
Authors: DIAO YUANAN , HETYEI GÁBOR , LIU PENGYU 
Published: January 2019

AbstractIt is well known that the minimum crossing number of an alternating link equals the number of crossings in any reduced alternating link diagram of the link. This remarkable result is an application of the Jones polynomial. In the case of the braid index of an alternating link, Yamada showed that the minimum number of Seifert circles over all regular projections of a link equals the braid index. Thus one may conjecture that the number of Seifert circles in a reduced alternating diagram of the link equals the braid index of the link, but this turns out to be false. In this paper we prove the next best thing that one could hope for: we characterise exactly those alternating links for which their braid indices equal the numbers of Seifert circles in their corresponding reduced alternating link diagrams. More specifically, we prove that if D is a reduced alternating link diagram of an alternating link L, then b(L), the braid index of L, equals the number of Seifert circles in D if and only if GS(D) contains no edges of weight one. Here GS(D), called the Seifert graph of D, is an edge weighted simple graph obtained from D by identifying each Seifert circle of D as a vertex of GS(D) such that two vertices in GS(D) are connected by an edge if and only if the two corresponding Seifert circles share crossings between them in D and that the weight of the edge is the number of crossings between the two Seifert circles. This result is partly based on the well-known MFW inequality, which states that the a-span of the HOMFLY polynomial of L is a lower bound of 2b(L)−2, as well as the result of Yamada relating the minimum number of Seifert circles over all link diagrams of L to b(L).
Linear bounds on characteristic polynomials of matroids
Authors: WANG SUIJIE , YEH YEONG–NAN , ZHOU FENGWEI 
Published: January 2019

AbstractLet χ(t) = a0tn – a1tn−1 + ⋯ + (−1)rartn−r be the chromatic polynomial of a graph, the characteristic polynomial of a matroid, or the characteristic polynomial of an arrangement of hyperplanes. For any integer k = 0, 1, …, r and real number x ⩾ k − r − 1, we obtain a linear bound of the coefficient sequence, that is
\begin{align*} {r+x\choose k}\leqslant \sum_{i=0}^{k}a_{i}{x\choose k-i}\leqslant {m+x\choose k}, \end{align*}
where m is the size of the graph, matroid, or hyperplane arrangement. It extends Whitney’s sign-alternating theorem, Meredith’s upper bound theorem, and Dowling and Wilson’s lower bound theorem on the coefficient sequence. In the end, we also propose a problem on the combinatorial interpretation of the above inequality.
Distinguishing differential susceptibility, diathesis-stress, and vantage sensitivity: Beyond the single gene and environment model
Authors: Jolicoeur-Martineau Alexia , Belsky Jay , Szekely Eszter , Widaman Keith F. , Pluess Michael , Greenwood Celia , Wazana Ashley 
Published: January 2019

AbstractCurrently, two main approaches exist to distinguish differential susceptibility from diathesis-stress and vantage sensitivity in Genotype × Environment interaction (G × E) research: regions of significance (RoS) and competitive-confirmatory approaches. Each is limited by its single-gene/single-environment foci given that most phenotypes are the product of multiple interacting genetic and environmental factors. We thus addressed these two concerns in a recently developed R package (LEGIT) for constructing G × E interaction models with latent genetic and environmental scores using alternating optimization. Herein we test, by means of computer simulation, diverse G × E models in the context of both single and multiple genes and environments. Results indicate that the RoS and competitive-confirmatory approaches were highly accurate when the sample size was large, whereas the latter performed better in small samples and for small effect sizes. The competitive-confirmatory approach generally had good accuracy (a) when effect size was moderate and N ≥ 500 and (b) when effect size was large and N ≥ 250, whereas RoS performed poorly. Computational tools to determine the type of G × E of multiple genes and environments are provided as extensions in our LEGIT R package.
Michelle Obama as a Political Symbol: Race, Gender, and Public Opinion toward the First Lady
Authors: Badas Alex , Stauffer Katelyn E. 
Published: January 2019

AbstractPopular commentary surrounding Michelle Obama focuses on the symbolic importance of her tenure as the nation's first African American first lady. Despite these assertions, relatively few studies have examined public opinion toward Michelle Obama and the extent to which race and gender influenced public evaluations of her. Even fewer studies have examined how the intersection of race and gender influenced political attitudes toward Michelle Obama and her ability to serve as a meaningful political symbol. Using public opinion polls from 2008 to 2017 and data from the Black Women in America survey, we examine public opinion toward Michelle Obama as a function of respondents’ race, gender, and the intersection between the two. We find that African Americans were generally more favorable toward Michelle Obama than white Americans, with minimal differences between men and women. Although white women were no more likely than white men to view Michelle Obama favorably, we find that they were more likely to have information on Michelle Obama's “Let's Move” initiative. Most importantly, we find that Michelle Obama served as a unique political symbol for African American women and that her presence in politics significantly increased black women's evaluation of their race-gender group.
Miniaturized open-ended dual-band band-pass filter with series stepped capacitance and shunt meandered line inductance for microwave frequency applications
Authors: Mishra Naveen , Choudhary Dilip Kumar , Chaudhary Raghvendra Kumar 
Published: January 2019

AbstractIn this paper, a miniaturized open-ended dual-band band-pass filter with stepped series capacitance and shunt meandered line inductance for microwave frequency applications has been designed and discussed. In order to offer ease of fabrication and uniplanar configuration, coplanar waveguide feeding arrangement has been used. Zeroth order resonance, a special phenomenon of composite right/left handed transmission line has been utilized to miniaturize the filter size. The designed filter structure offers miniaturization with overall footprint size of 0.26λg × 0.19λg, where λg is the guided wavelength at the center frequency of 1.46 GHz. It offers 58.90% (1.03–1.89 GHz) and 25.93% (2.55–3.31 GHz) measured −3 dB fractional bandwidth with respect to the center frequencies of 1.46 and 2.93 GHz, respectively. Dispersion plot has been utilized to discuss the metamaterial properties for the proposed dual-band band-pass filter. In addition to above, the proposed filter structure presents almost flat group delay curve within both passbands. The proposed filter structure can be suitably utilized for distinct wireless applications, for example global navigation satellite system (1.559–1.610 GHz), GSM1800 (1.7–1.8 GHz), Wi-MAX (2.5–2.7 GHz), and naval radar and air traffic control (2.7–2.9 GHz).
Design and implementation of 2.5D frequency-selective surface based on substrate-integrated waveguide technology
Authors: Varikuntla Krushna Kanth , Singaravelu Raghavan 
Published: January 2019

AbstractIn this paper, the patch-type frequency selective surfaces (FSS) based on substrate-integrated waveguide (SIW) technology is proposed to improve the bandwidth (BW) and angular performance. The proposed FSS configuration overcomes the limitations of both conventional 2D and 3D FSS structures. A closely coupled cascaded mechanism is employed to combine two identical FSS elements separated by thin dielectric substrate results in incorporation of SIW technology; hence, named as 2.5D FSS. A derived equivalent circuit model is used to estimate the basic performance of proposed FSS–SIW elements, and the response of analytical expressions has been validated and final design is obtained using full-wave simulations. Two basic FSS elements viz. single square loop and a Jerusalem cross have been investigated to prove the enhancement in their BW and angular stability. The proposed technique evidently improves the BW and angular stability of FSS structures than in its established form. Besides, various important parameters that influence the performance characteristics of reported 2.5D FSSs are also studied. The important observations made on the thickness, as the thickness increases the bandstop FSS, can change to bandpass FSS. Finally, the proposed FSS structure has been fabricated and measured using free space measurement setup, to show the effectiveness of theoretical results. The measured results show good agreement with simulated results at normal and oblique incidence angle.
The Influence of Competing Hydroclimate Processes on Stable Isotope Ratios in Tropical Rainfall
Authors: Konecky B. L. , Noone D. C. , Cobb K. M. 
Published: January 2019

AbstractIn tropical paleoclimate studies, paleo‐precipitation is often reconstructed from proxies via the “amount effect,” that is, the empirical inverse relationship between local precipitation amount (P) and the oxygen isotopic composition of precipitation (δ18OP). However, recent research has illustrated numerous microphysical and dynamical controls on δ18OP that do not necessarily covary with P, complicating the reconstruction of circulation features like the Intertropical Convergence Zone. Here we introduce a new conceptual and statistical model for δ18OP that better captures the physical foundations for δ18OP as a tracer of hydrological balance. We find that bulk precipitation microphysics and cloud type exert comparable influences on δ18OP. Moisture transport plays an important secondary role in regions of deep atmospheric convection such as the Intertropical Convergence Zone and Indo‐Pacific Warm Pool. Our findings help reconcile conflicting interpretations of Intertropical Convergence Zone excursions, and provide a firm physical grounding for more nuanced, accurate interpretations of past hydroclimate using water isotope proxies.
Methane Emissions from the Marcellus Shale in Southwestern Pennsylvania and Northern West Virginia Based on Airborne Measurements
Authors: Ren Xinrong , Hall Dolly L. , Vinciguerra Timothy , Benish Sarah E. , Stratton Philip R. , Ahn Doyeon , Hansford Jonathan R. , Cohen Mark D. , Sahu Sayantan , He Hao , Grimes Courtney , Fuentes Jose D. , Shepson Paul B. , Salawitch Ross J. , Ehrman Sheryl H. , Dickerson Russell R. 
Published: January 2019

AbstractNatural gas production in the United States has increased rapidly over the past decade, along with concerns about methane (CH4) fugitive emissions and its climate impacts. Quantification of CH4 emissions from oil and natural gas (O&NG) operations is important for establishing scientifically sound policies for mitigating greenhouse gases. We use the aircraft mass balance approach for three flight experiments in August and September 2015 to estimate CH4 emissions from O&NG operations over the southwestern Marcellus Shale. We estimate a mean CH4 emission rate as 21.2 kg/s with 28% coming from O&NG operations. The mean CH4 emission rate from O&NG operations was estimated to be 1.1% of total NG production. The individual best‐estimate emission rates from the three flight experiments ranged from 0.78 to 1.5%, with overall limits of 0% and 3.5%. These emission rates are at the low end of other top‐down studies, but consistent with the few observational studies in the Marcellus Shale region as well as the U.S. Environmental Protection Agency CH4 inventory. A substantial source of CH4 (~70% of observed CH4 emissions) was found to contain little ethane, possibly due to coalbed CH4 emitted either directly from coal mines or from wells drilled through coalbed layers in O&NG operations. Recent regulations requiring capture of gas from the completion‐venting step of hydraulic fracturing appear to have reduced the atmospheric release of CH4. Our study suggests that for a 20‐year time scale, energy derived from the combustion of natural gas extracted from this region likely exerts a net climate benefit compared to coal.
Quantifying the Sensitivity of Progressive Landslide Movements to Failure Geometry, Undercutting Processes and Hydrological Changes
Authors: Leshchinsky Ben , Olsen Michael J. , Mohney Curran , O'Banion Matt , Bunn Michael , Allan Jonathan , McClung Reilly 
Published: January 2019

AbstractMany landslides cause destruction through progressive, gradual movements that stem from precipitation and toe erosion caused by marine or riverine processes. The magnitude and timing of seasonal landslide movement may be influenced by changing slide mass geometry and pore pressure response. The rate of landslide advance and potential for sustained movement has previously been studied in the context of hydrological factors, such as dilative or contractive pore pressure response, but the sensitivity of realistic landslide geometry subject to toe erosion is not well quantified. The purpose of this study is to assess the sensitivity of landslide movements to seasonal pore pressure increases and erosive processes. This assessment is performed through the development of a limit equilibrium framework couples time‐dependent feedback between coulomb friction, pore pressure, and evolving landslide geometry. This enables quantification of the relative influence of time‐dependent changes in pore pressure and rates of toe undercutting on landslide advance. The proposed model shows good agreement with monitoring data from three landslides in coastal Oregon, USA. Sensitivity to erosion, pore pressure, and geometry are assessed. Although fluctuations in pore pressures are found to be the primary driver for landslide movements at the sites, there is significant, nonlinear sensitivity to plausible erosion rates. This sensitivity is particularly apparent for landslides that tend to be short in length as the removal of buttressing materials is proportionally more destabilizing. These findings are an important consideration, particularly as increasingly extreme storm events that will likely magnify landslide movements in coastal or fluvial environments.
Present and Past‐Millennial Eutrophication in the Gulf of Gdańsk (Southern Baltic Sea)
Authors: Szymczak‐Żyła M. , Krajewska M. , Witak M. , Ciesielski T. M. , Ardelan M. V. , Jenssen B. M. , Goslar T. , Winogradow A. , Filipkowska A. , Lubecki L. , Zamojska A. , Kowalewska G. 
Published: January 2019

AbstractEutrophication is manifested by increased primary production leading to oxygen depletion in near‐bottom water and toxic cyanobacteria blooms. This is an important contemporary problem of the Baltic Sea and many other coastal waters. The present eutrophication is mainly ascribed to anthropogenic activity. To compare the present trophic state with that during past millennia, two sediment cores (50 cm long and ~400 cm long covering ca. 5,500 years) were taken from the Gulf of Gdańsk (southern Baltic Sea). The core subsamples were analyzed for phytoplankton pigments (chlorophylls and their derivatives, and carotenoids). In addition, carbon (Ctot, Corg, and δ13C), 14C dating, grain size, diatoms, and selected metals in the cores were analyzed to determine conditions in the depositional environment. The results indicated that there were high primary production periods in the past, during the Littorina Sea and the Roman Climatic Optimum, accompanied by oxygen deficiency in the near‐bottom water, most probably caused by climate warming. The ratio of 132,173‐cyclopheophorbide‐a enol, a labile degradation product of chlorophyll‐a, to the sum of other chloropigments‐a (CPPB‐aE/ΣChlns‐a) is proposed as a new paleoredox proxy. Heterocystous cyanobacteria blooms of an intensity similar to or even greater than at present also occurred in past millennia and were connected with climate warming. Hence, eutrophication must have occurred in the past, which means that natural factors have a substantial influence on it.
Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D
Authors: Hu Peishan , Li Shanshan , Tian Ningyu , Wu Fan , Hu Yan , Li Dengke , Qi Yingjiao , Wei Zhizhong , Wei Qunfang , Li Yanchao , Yin Bin , Jiang Tao , Yuan Jiangang , Qiang Boqin , Han Wei , Peng Xiaozhong 
Published: January 2019

AbstractAcidosis is a significant feature of the tumor microenvironment in glioma, and it is closely related to multiple biological functions of cancer stem cells. Here, we found that the self-renewal ability, the mitochondrial activity and ATP production were elevated in stem cell-like glioma cells (SLCs) under acidic microenvironment, which promoted and maintained the stemness of SLCs. Under acidosis, 25-hydroxy vitamin D3-24-hydroxylase (CYP24A1) was upregulated and catalyzed the fast degradation of 1α,25(OH)2D3. We further revealed that the active form of vitamin D (1α,25(OH)2D3) could inhibit the expression of stemness markers, attenuate acidosis-induced increase of self-renewal ability and mitochondrial respiration in stem cell-like glioma cells. Our study indicates that the acidosis–CYP24A1–vitamin D pathway may be a key regulator of the cancer stem cell phenotype in malignant glioma and point out the potential value for the utilization of vitamin D to target cancer stem cells and to restrain the growth of malignant glioma in the future.
CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling via transactivation of GSK-3β and Axin2 expression
Authors: Yu Junhui , Liu Dong , Sun Xuejun , Yang Kui , Yao Jianfeng , Cheng Chen , Wang Chunbao , Zheng Jianbao 
Published: January 2019

AbstractCaudal-related homeobox transcription factor 2 (CDX2), an intestine-specific nuclear transcription factor, has been strongly implicated in the tumourigenesis of various human cancers. However, the functional role of CDX2 in the development and progression of colorectal cancer (CRC) is not well known. In this study, CDX2 knockdown in colon cancer cells promoted cell proliferation in vitro, accelerated tumor formation in vivo, and induced a cell cycle transition from G0/G1 to S phase, whereas CDX2 overexpression inhibited cell proliferation. TOP/FOP-Flash reporter assay showed that CDX2 knockdown or CDX2 overexpression significantly increased or decreased Wnt signaling activity. Western blot assay showed that downstream targets of Wnt signaling, including β-catenin, cyclin D1 and c-myc, were up-regulated or down-regulated in CDX2-knockdown or CDX2-overexpressing colon cancer cells. In addition, suppression of Wnt signaling by XAV-939 led to a marked suppression of the cell proliferation enhanced by CDX2 knockdown, whereas activation of this signaling by CHIR-99021 significantly enhanced the cell proliferation inhibited by CDX2 overexpression. Dual-luciferase reporter and quantitative chromatin immunoprecipitation (qChIP) assays further confirmed that CDX2 transcriptionally activates glycogen synthase kinase-3β (GSK-3β) and axis inhibition protein 2 (Axin2) expression by directly binding to the promoter of GSK-3β and the upstream enhancer of Axin2. In conclusion, these results indicated that CDX2 inhibits the proliferation and tumor formation of colon cancer cells by suppressing Wnt/β-catenin signaling.
Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency
Authors: Wang Pingping , Wei Wei , Ye Wei , Li Xiaodong , Zhao Wenfang , Yang Chengshuai , Li Chaojing , Yan Xing , Zhou Zhihua 
Published: January 2019

AbstractSynthetic biology approach has been frequently applied to produce plant rare bioactive compounds in microbial cell factories by fermentation. However, to reach an ideal manufactural efficiency, it is necessary to optimize the microbial cell factories systemically by boosting sufficient carbon flux to the precursor synthesis and tuning the expression level and efficiency of key bioparts related to the synthetic pathway. We previously developed a yeast cell factory to produce ginsenoside Rh2 from glucose. However, the ginsenoside Rh2 yield was too low for commercialization due to the low supply of the ginsenoside aglycone protopanaxadiol (PPD) and poor performance of the key UDP-glycosyltransferase (UGT) (biopart UGTPg45) in the final step of the biosynthetic pathway. In the present study, we constructed a PPD-producing chassis via modular engineering of the mevalonic acid pathway and optimization of P450 expression levels. The new yeast chassis could produce 529.0 mg/L of PPD in shake flasks and 11.02 g/L in 10 L fed-batch fermentation. Based on this high PPD-producing chassis, we established a series of cell factories to produce ginsenoside Rh2, which we optimized by improving the C3–OH glycosylation efficiency. We increased the copy number of UGTPg45, and engineered its promoter to increase expression levels. In addition, we screened for more efficient and compatible UGT bioparts from other plant species and mutants originating from the direct evolution of UGTPg45. Combining all engineered strategies, we built a yeast cell factory with the greatest ginsenoside Rh2 production reported to date, 179.3 mg/L in shake flasks and 2.25 g/L in 10 L fed-batch fermentation. The results set up a successful example for improving yeast cell factories to produce plant rare natural products, especially the glycosylated ones.
Nb/Ta systematics in arc magma differentiation and the role of arclogites in continent formation
Authors: Tang Ming , Lee Cin-Ty A. , Chen Kang , Erdman Monica , Costin Gelu , Jiang Hehe 
Published: January 2019

AbstractThe surfaces of rocky planets are mostly covered by basaltic crust, but Earth is unique in that it also has extensive regions of felsic crust, manifested in the form of continents. Exactly how felsic crust forms when basaltic magmas are the dominant products of melting the mantles of rocky planets is unclear. A fundamental part of the debate is centered on the low Nb/Ta of Earth’s continental crust (11–13) compared to basalts (15–16). Here, we show that during arc magma differentiation, the extent of Nb/Ta fractionation varies with crustal thickness with the lowest Nb/Ta seen in continental arc magmas. Deep arc cumulates (arclogites) are found to have high Nb/Ta (average ~19) due to the presence of high Nb/Ta magmatic rutiles. We show that the crustal thickness control of Nb/Ta can be explained by rutile saturation being favored at higher pressures. Deep-seated magmatic differentiation, such as in continental arcs and other magmatic orogens, is thus necessary for making continents.