bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of prognostic factors for the development of sialadenitis on the background of radioiodine therapy
Authors: Razumova A. Ya. , Kutukova S. I. , Yaremenko A. I. , Borodavina E. V. , Petrov N. L 
Published: November 2024

Introduction. Radioiodine therapy is a modern method of treating thyroid pathology. Its use is possible both in malignant tumors and in thyrotoxicosis. However, this technique has a complication in the form of impaired salivary gland function, which causes dryness in the oral cavity, its increase and pain syndrome.The aim of our study to identify risk factors for the development of functional disorders of the salivary glands in patients who underwent radioiodine therapy. Material and methods. A retro-prospective open-label, two-center, non-randomized study was conducted, which included 61 patients who received radiotherapy for thyroid diseases. In 33/61 patients, there were no signs of sialadenitis development on the background and after radioiodine therapy. Twenty-eight patients (28/61) who had a lesion of the salivary gland on the background of ongoing therapy. A statistical analysis of data on gender, age, the main clinical diagnosis, the stage of the underlying disease, the received dose of I131, the presence or absence of sialadenitis, the time from the start of radionuclide therapy to the development of sialadenitis was carried out. Results. When analyzing the data obtained, it was revealed that independent adverse factors that increase the risk of developing salivary gland lesions in patients who received at least one session of radioiodine therapy were: female (p = 0.0219; HR 10.38: 95% CI 1.40–76.84) and age 61 years and younger (p = 0.0004; HR 1.04: 95% CI 1.02–1.06). And the median of the total accumulated dose of the radiopharmaceutical did not show its significance in the multifactorial analysis. Conclusion. The development of chronic sialadenitis on the background of radioiodine therapy is a multifactorial pathology. This pathology requires dynamic monitoring and preventive measures, especially the risk group (female and age 61 years and younger).
Comparative analysis of the parameters of local immunity of oral fluid and the duration of the course in children with systemic lupus erythematosus, juvenile scleroderma, juvenile dermatomyositis, juvenile idiopathic arthritis and systemic vasculitis
Authors: Skakodub A. A. , Kozlitina Yu. A. , Admakin O. I. , Geppe N. A. , Osminina M. K. , Petukhova A. I. , Shevlakova A. V. 
Published: November 2024

Immunoglobulins are considered to be the main factor of specific antimicrobial protection of oral tissues.The study was conducted on the basis of the University Children’s Clinical Hospital of the I.M. Sechenov First Moscow State Medical University of the N.F. Filatov Clinical Institute of Child Health, in the Department of Rheumatology. The study involved 316 children, with diseases: systemic lupus erythematosus (SLE), juvenile dermatomyositis (YDM), juvenile limited scleroderma (YOSD), juvenile systemic scleroderma (YSSD), juvenile idiopathic arthritis (JIA), systemic vasculitis (SV) and Behcet’s disease (BB) and were divided into age groups according to the duration of the course of the underlying disease. The analysis of the results revealed a decrease in the content of IgG, IgA, sIgA in saliva in children with rheumatic diseases in all age groups compared with the control group (children without somatic diseases). With the duration of the course of the disease up to 2 years, the most pronounced decrease in the content of IgG, IgA, sIgA in saliva was revealed, more than 4–10 times (p<0.05), and with a duration of more than 2 years, a decrease of 2–3 times (p<0.01), compared with the control group. The deficiency of these immunoglobulins shows that in children with rheumatic diseases, regardless of the nosology, there is a violation of the local immunity of the oral cavity, especially at the onset of the underlying disease (in groups up to 2 years of the duration of the course of the underlying disease), with pronounced autoimmune inflammation of tissues and blood vessels, and this is also facilitated by the reception, during this period of shock doses of glucocorticosteroids, cytostatics, immunosuppressors, which leads to severe inflammatory processes of the oral mucosa, periodontal and hard tissues of the teeth.
Clinical experience of tooth replantation
Authors: Ivashchenko A. V. , Yablokova A. E. , Tlustenko V. P. 
Published: November 2024

Relevance.Modern dental practice strives, above all, to preserve teeth. A variety of operations aimed at this include dental replantation. Replantation is used in cases where there are difficulties with the root canals, such as their pathological bending or previous treatment with the resorcinol-formalin method, and also when root resection is impossible due to the risk of damage to surrounding structures, for example, the maxillary sinus or the inferior alveolar nerve.The purposeof this study was to study the osseointegration of a replanted tooth subjected to coronoradicular separation.Materials and methods.Thirty-one-year-old patient K. came to the dental clinic with the problem of pain in the projection of tooth 4.6, which occurs during chewing. A detailed examination revealed that the crown of tooth 4.6 had previously undergone restoration using a filling material that had defects. It was decided that tooth 4.6 should be removed and subsequently replanted. The tooth was extracted according to established procedures, while maximally preserving the surrounding periodontal and periosteal tissues. To preserve periodontal tissues, alveolar curettage was carefully performed. During the extraction of the tooth, it was longitudinally divided into two parts – the medial and distal roots. After this, the root canals were treated using extraoral therapy. The roots of tooth 4.6, treated with an antiseptic, were returned to their anatomical positions in the alveolus. The final stage was the creation of a control x-ray to verify the correctness of the replantation.Conclusions.After two years of observation of tooth 4.6, which was subjected to replantation, no pathological changes in root stability were detected. It was reported that the soft tissue surrounding the roots of the tooth formed a structure similar to the periodontal sulcus, which facilitated the use of retraction cord during tooth preparation.
Diagnostic significance of the method of computerized joint vibration analysis in studying the functional state of temporomandibular joints
Authors: Domenyuk D. A. , Boyko E. M. , Davydov B. N. , Kochkonyan T. S. , Domenyuk S. D. 
Published: November 2024

polyetiology, progressive course and high frequency of relapses is one of the urgent problems of modern dentistry. Different conceptual approaches to the analysis of etiological and pathogenetic aspects of the development of dysfunctional TMJ disorders predetermine the increased interest in the search for highly informative diagnostic methods, especially at the stage of preclinical manifestations.Goal. Evaluation of possibilities of computerized joint vibration analysis method in diagnostics of TMJ functional state.Materials and methods. The study involved 42 people of both sexes with physiologic types of bite, preserved tooth rows, no signs of functional disorders in TMJ and masticatory muscles. The patients underwent clinical dental examination, «Hamburg test», selective grinding of teeth, and measurement of mouth opening amplitude. Joint vibration analysis was performed on the hardware-software complex «BioPAK» with registration of TMJ noise oscillations according to the following indices: «Total Integral», «High Integral», «Low Integral», «Ratio». A flow chart (Ishigaki S. et al., 1993) was used to interpret the numerical values. The functional state of TMJ was de-termined according to the flowchart using numerical parameters in accordance with the classification of TMJ disorders (Wilkes С.Н., 1989).Results. In patients with physiologic occlusion, according to joint vibration analysis, Me «Total Integral» of the right TMJ was 11.7 PaHz, left TMJ – 12.6 PaHz, [Q-25; Q-75] – [9.3; 15.1] PaHz and [10.5; 18.3] PaHz respectively, Me «High Integral» of the right TMJ – 1.3 PaHz, left TMJ – 1.4 PaHz, [Q-25; Q-75] – [1.0; 1.8] PaHz and [1.2; 2.1] PaHz respectively, with no statistically significant (p≤0.05) differences in the studied parameters between the right and left TMJ.Conclusions. The diagnosis of «structurally intact» TMJ, corresponding to stage I of the American classification of TMJ disorders (Wilkes S.N., 1989) in people with physiologic types of bite, is confirmed by the numerical values [Q-25; Q-75] of «Total Integral», «High Integral» (block diagram of S. Ishigaki et al., 1993), the degree of maximum mouth opening [43; 50] mm in the absence of pronounced signs of facial asymmetry.
The comorbid pathology in patients with chronic apical periodontitis
Authors: Bagryantseva N. V. 
Published: November 2024

The purpose of this study was to study the relationship between teeth after endodontic treatment and/or with apical periodontitis, in patients with a number of systemic diseases and smokers among the adult population of Yaroslavl.Materials and methods of research. Medical history data were collected, including age, gender, presence of cardiovascular diseases, diabetes mellitus, allergies, smoking habits and data on endodontic dental treatment of 421 patients (10,540 teeth). The prevalence of depulpated teeth and the periodontal condition were assessed by orthopantomograms. The periapical status was classified according to the periapical Index PAI (PAI), chronic apical periodontitis was defined as PAI-score ≥3. The statistical analysis was carried out using the Stata/MP v. program.17.0 (StataCorp LLC, Texas 77845-4512, USA) using chi-square tests, odds ratio and confidence intervals (95%).The results and their discussion. The overall prevalence of chronic apical periodontitis and the prevalence of teeth after endodontic treatment was 2.2 and 4.2%, respectively. The high prevalence of depulpated teeth increased the likelihood of chronic apical periodontitis (p<0.0001). In the group of men, there was a higher percentage of teeth with chronic apical periodontitis (p<0.0001), a lower percentage of teeth after endodontic treatment (p=0.05) and a greater number of residual roots (with complete destruction of the crown of the tooth) (2.3%). Smokers were more likely to have teeth with chronic apical periodontitis (p=0.002) and the prevalence of teeth after endodontic treatment (p=0.045). A positive correlation was observed between the prevalence of teeth after endodontic treatment and diabetes mellitus (p=0.040).Conclusion. A higher prevalence of chronic apical periodontitis and/or teeth after endodontic treatment in smokers and patients with diabetes mellitus may indicate a relationship between the condition of the oral cavity and a number of systemic diseases.
Photodynamic therapy – modern views and innovations in dentistry
Authors: Risovannaya O. N. , Andreasyan T. Sh. 
Published: November 2024

Photodynamic therapy (PDT) consists of three elements: a photosensitizer, light and oxygen. The photosensitizer has the property of selective accumulation in target tissues without harming healthy cells. This innovative therapeutic method has already been successfully adapted in many areas of medicine, such as dermatology, gynecology, urology and oncology. PDT is also beginning to be introduced in dentistry. The antibacterial and fungicidal properties of the photosensitizer are used to achieve better results in the medical and surgical treatment of patients. Objective. To analyze current scientifi data on the application of photodynamic therapy (PDT) in various fi of dentistry, evaluate its effectiveness, and assess prospects for development. Materials and methods. A review of recent scientifi literature was conducted, including original studies, systematic reviews, and meta-analyses focused on PDT application in dentistry. Data on mechanisms of action, clinical efficacy, and new developments in PDT were analyzed. Results. High effi of PDT was established in the treatment of periodontal diseases, peri-implantitis, endodontic infections, and oral oncological diseases. Advantages of combined application of PDT with other treatment methods were noted. Promising directions for PDT development were identifi including the creation of new photosensitizers and technological innovations in equipment. Conclusions. PDT is a promising treatment method in dentistry, demonstrating high efficacyand safety. Further research is aimed at optimizing treatment protocols, developing personalized approaches, and integrating PDT with other modern technologies.
Optimizing the treatment of patients with intrinsic temporomandibular joint disorders
Authors: Kazarian G. G. , Bekreev V. V. , Kladnichkin I. D. , Salekh K. M. , Degtyarev N. E. 
Published: November 2024

Temporomandibular joint (TMJ) dysfunctions are conditions in which there is a disruption in the anatomical and functional relationship between the various structures of the joint, including the articular disc, intra-articular ligaments, mandibular head and capsule. These disorders have a negative impact on the patient’s quality of life, resulting in limitations in masticatory function and articulation. The multifactorial nature of this pathology emphasizes the need for an individualized and comprehensive approach to the treatment of each patient. In most cases, treatment includes both surgical and orthopedic methods. Currently, combined treatment approaches aimed at synergistic effects are being actively developed to maximize therapeutic Results.The purpose of this study. To evaluate the efficacy of the combination of treatment with a repositioning mouthguard and the use of the hydraulic articular disk repositioning method in patients with internal TMJ disorders combined with dental row end defects.Materials and methods. The study included 6 patients with TMJ dysfunction and end defects of the dentition. The study was conducted between September 2023 and May 2024. As part of the study, each patient underwent cone beam computed tomography (CBCT) to evaluate the bony structures of the TMJ and ultrasound (US) to evaluate the soft tissue structures of this joint.Results. The CBCT data showed that the mean posterior temporomandibular joint displacement before treatment was 1.67, while this value increased to 3.02 after treatment. The US results showed a significant decrease in the mean value of mandibular head displacement after treatment ranging from 0.21 to 0.03, indicating a positive effect of treatment. In addition, there was a decrease in the difference in the size of the anterior and posterior parts of the articular disc, confirming the elimination of its displacement.Conclusion. The treatment combination of using a repositioning mouth guard with the hydraulic repositioning method brought about a synergistic effect on the restoration of TMJ function.
Association between delayed invasive blood pressure monitoring and all-cause mortality in intensive care unit patients with sepsis: a retrospective cohort study
Authors: Xiao Li , Shen Pu , Han Xue , Yu Yi 
Published: November 2024

PurposeHaemodynamic management is essential in sepsis management. Invasive blood pressure (IBP) monitoring is the gold standard for blood pressure (BP) assessment. Here, we identified the most advantageous time frame for IBP monitoring to mitigate adverse outcomes in patients with sepsis.MethodsWe included data on patients with sepsis from the Medical Information Mart for Intensive Care IV database. The primary endpoints comprised 28-and 90-day mortality rates, whereas secondary endpoints were acute kidney injury (AKI) rates and continuous renal replacement therapy (CRRT) requirement. To confirm our findings’ robustness, we performed multivariable Cox regression and logistic regression models, augmented by propensity score matching (PSM).ResultsOf 18,326 patients hospitalised for sepsis, 9,056 (49.42%) and 9,270 (50.58%) were included in the early and delayed IBP-monitoring groups, respectively. Our multivariable Cox regression models revealed 20 and 21% significant increases in 28-and 90-day mortality in the delayed IBP monitoring group, respectively [hazard ratios (95% confidence intervals) = 1.20 (1.11–1.31) and 1.21 (1.12–1.31), respectively; both p &lt; 0.001]. Moreover, significant increases were noted in AKI, CRRT and mechanical ventilation requirement risks in the delayed IBP monitoring group [odds ratios (95% confidence intervals) = 1.44 (1.34–1.56), 1.50 (1.26–1.78) and 1.79 (1.67–1.92), respectively; both p &lt; 0.001]. PSM further confirmed the validity of our findings. Delayed IBP monitoring prolonged intensive care unit (ICU) stay without extending vasopressor use duration.ConclusionProlonged delay in IBP monitoring (≥3 h) may increase mortality risks in ICU patients with sepsis. Nevertheless, early IBP monitoring may reduce AKI, CRRT and mechanical ventilation requirement risks and shorten ICU stay. However, these results warrant further validation through randomised controlled trials.
Students Perception on Soft Skills in Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia
Authors: Sulistiyana Catur Setiya , Fauzan Zamzam Ahmad , Permatasari Tissa Octavira , Khasanah Uswatun 
Published: November 2024

Background: Soft skills is important attributes of professionalism in the practice of medicine. Soft skills to be known as person's ability beyond knowledge, intelligence, or competence. Faculty of Medicine in Universitas Swadaya Gunung Jati, Cirebon, Indonesia, has used various learning methods to support students' skills, allowing students to have different perspectives in understanding soft skills.
Aims: To identify the perception of medical students at Faculty of Medicine, Swadaya Gunung Jati University, in the pre-clinical stage towards soft skills.
Methods: This was an observational descriptive study. Respondents were selected using Stratified Random Sampling techniques, sample size was 262 respondents were obtained from semester 2, 4, 6 and 8. This study used primary data with 42 statement items with univariate analysis.
Results: From 262 respondents, of 93.1% students (244) have a good perception of the definition of soft skills. As many as 50.4% (123) of 262 respondents have a good perception of time management. As many as 81.3% (213) of 262 respondents have a good perception of critical thinking. 73.7% (193) of 262 respondents have a good perception of teamwork. As many as 87.4% (229) of 262 respondents have a good perception of public speaking.
Conclusion: This study showed medical student perception of soft skills regarding definition, time management skills, critical thinking, teamwork, and public speaking had a good perception. In the future, Faculty needs to provide space for students to develop these soft skills through training or interprofessional education and other programs.

Received: 10 September 2024 | Reviewed: 16 October 2024 |
Revised: 23 October 2024 | Accepted: 31 October 2024.
Ride-Hailing Drivers’ Preference for Fairwork Principles of Trustworthy Labour-Platform Management and Greater Worker-Autonomy and Willingness to Form and Join Worker-Platform Co-Operatives in Kenya
Authors: Matabi Jared Mark Ochieno , Gicheru Esther Njoki , Kiganane Lucy Maina 
Published: November 2024

Ride-hailing worker-platform co-operatives had emerged as part of and for at least fairwork principles. Moreover, studies on e-drivers have recommended the formation of worker-platform co-operatives in Kenya. The actual worker-platform co-operatives by e-drivers are yet to be established. It was against this backdrop that a study was conducted to determine the extent of ride-hailing drivers’ preference for fairwork principles of trustworthy labour-platform management, greater worker-autonomy and willingness to form and join worker-platform co-operatives. The study was grounded in the social exchange theory, affective theory of social exchange, and utility theory. The researcher applied critical-realism research philosophy and multimethod research designs of discrete choice experiments and sequential explanatory mixed method research designs. Using the Yamane sampling formula, the study used quantitative data from 497 respondents from sampled 600 of the 20,000 e-drivers in the Nairobi Metropolitan Region. The quantitative data was analysed using multinominal logistic regression. Moreover, the study used qualitative data from 11 participants, analysed using thematic analysis. Results indicated that the two fairwork principles were statistically significant to e-drivers’ willingness to form and join worker-platform co-operatives. The trustworthy platform management (TPM) principle, in particular, was a highly preferred fairwork principle in terms of e-drivers’ willingness to form and join worker-platform co-operative model (Coeff=2.62; SE = 0.400, Z = 6.54, p< .001), compared to the greater worker-autonomy contract (GAC) principle (Coeff=1.565, SE = 0.202, Z = 7.74, p< .001). This study brings practical and theoretical contributions to improve the e-drivers’ benefits from the ride-hailing sector. Policymakers, promoters, and platform workers like e-drivers could understand how best to promote worker-platform co-operatives to succeed in the country’s societal context.