bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pentoxifylline improves the quality of life in type-2 diabetes foot syndrome
Authors: Al-Nimer Marwan S , Ratha Rawa A , Mahwi Taha O 
Published: August 2019

Objectives: To evaluate the effect of pentoxifylline on the quality of life (QoL) in diabetic foot syndrome (DFS) by using Short Form-36 questionnaire, and in reference to the revised neuropathy disability score (RNDS) and grading of diabetic foot.
Methods: This randomized placebo-controlled study was carried in the Department of Pharmacology at University of the Sulaimani through 2018. A total number of 80 T2D patients were recruited from outpatients Department attended the Center of Diabetes and the Shar Teaching Hospital in the University of Sulaimani, Sulaimani-Iraq. Group I (non-DFS, n=40) were subgrouped into Group-IA treated with placebo (n=20), and Group-IB treated with 400 mg pentoxifylline thrice daily for 8 weeks. Group II (DFS, n=40) sub grouped into Group-IIA treated with placebo (n=20), and Group-IIB treated with pentoxifylline. The primary outcome measures including the data of SF-36, RNDS, and grading of diabetic foot.
Results: Pentoxifylline therapy significantly reduced the RNDS, improved the clinical evidence of diabetic foot, improved the QoL particularly the domains that related to emotional problems and physical health. Pentoxifylline offered a better effect in DFS compared with non-DFS patients
Conclusion: Pentoxifylline treatment improves the quality of life in diabetic foot syndrome and its effect is related to the scoring of revised neuropathy disability and grading of diabetic foot.
doi: https://doi.org/10.12669/pjms.35.5.11
How to cite this:Al-Nimer M, Ratha R, Mahwi T. Pentoxifylline improves the quality of life in type-2 diabetes foot syndrome. Pak J Med Sci. 2019;35(5):1370-1375. doi: https://doi.org/10.12669/pjms.35.5.11
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Autoimmune cytopenias in chronic lymphocytic leukemia
Authors: Haider Mohammad Shabih , Khan Saleem Ahmed , Khattak Nasiruddin , Shahid Samra 
Published: August 2019

Objective: To determine the frequency of autoimmune cytopenias in chronic lymphocytic leukemia.
Methods: This cross sectional study was carried out at Department of Hematology, Army Medical College Rawalpindi, in collaboration with Military Hospital Rawalpindi and Armed Forces institute of Pathology Rawalpindi from 1st January 2018 to 1st October 2018. Sample size of 64 was calculated using WHO calculator. Age and gender of patients was noted. Frequency of autoimmune hemolytic anaemia, immune thrombocytopenic purpura, pure red cell aplasia and autoimmune agranulocytosis were determined in diagnosed patients of chronic lymphocytic leukemia by various laboratory tests in our study population.
Results: A total of 64 patients were included in the study, 53 (82.8%) were males and 11(17.2%) were females. Mean age of patients was 65 years. Autoimmune hemolytic anaemia was observed in 5/64 (7.8%) of patients. Immune thrombocytopenic purpura was seen in 2/64 (3.1%) patients. Autoimmune granuloytopenia and pure red cell aplasia were not seen in any patient.
Conclusion: Autoimmune hemolytic anaemia and immune thrombocytopenic purpura are the most common causes of immune cytopenias in patients of CLL. Immune cytopenias should always be identified by laboratory tests as their management differs from other cytopenias which occur due to various other causes.
doi: https://doi.org/10.12669/pjms.35.5.369
How to cite this:Haider MS, Khan SA, Nasiruddin, Shahid S. Autoimmune cytopenias in chronic lymphocytic leukemia. Pak J Med Sci. 2019;35(5):1334-1338. doi: https://doi.org/10.12669/pjms.35.5.369
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Harlequin fetus born from Consanguinity: A deleterious case report
Authors: Devnani Joti , Kumari Ujalla , Rubab Zil-e- 
Published: August 2019

Harlequin Ichthyosis (HI) is a dreadful skin disorder with steady rise of cases with prolonged survival. Harlequin fetus follows an autosomal recessive pattern with the incidence of 1in 300,000 live births. In the succeeding case report, a male child was born with keratinized and kaleidoscopic diamond pattern of skin suggestive of HI. He was born at 36th week of gestation from consanguineous marriage. The newborn remained under extensive intensive care in a tertiary care unit where he breathed his last on 11th day after birth. Prenatal diagnosis and genetic counseling is of vital importance due to the association of ABCA12 mutation with HI.
doi: https://doi.org/10.12669/pjms.35.5.916
How to cite this:Devnani J, Kumari U, Zil-e-Rubab. Harlequin fetus born from Consanguinity: A deleterious case report. Pak J Med Sci. 2019;35(5):1472-1474. doi: https://doi.org/10.12669/pjms.35.5.916
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Validity and test-retest reliability of a patient-reported outcome measure for an outpatient cardiac rehabilitation programme
Authors: Cowie Aynsley , Hair Mario , Kerr Emma , McKay Janet , Allan Lesley , Thomson Patricia 
Published: August 2019

Background/Aims This article details how a patient-reported outcome measure (PROM), termed PROM-CR1, was tested for acceptability, validity and test-retest reliability at the end of an outpatient cardiac rehabilitation programme. Methods PROM-CR1 was completed by 138 service users (mean age 66.95 years, range 42–94 years; 115 males, 23 females; with a range of cardiac diagnoses), who used the tool at home twice: once at the end of the outpatient cardiac rehabilitation programme and 1 week later. Results PROM-CR1 demonstrated good acceptability, construct and concurrent validity, and test-retest reliability. The construct validity analysis highlighted that one item required removal from the PROM-CR1. Conclusions A finalised 30-item version of the tool will now be widely disseminated and further evaluated within cardiac rehabilitation clinical practice.
Should the primary percutaneous coronary intervention pathway be redesigned?
Authors: Dean Sue 
Published: August 2019

Background/Aims The primary percutaneous coronary intervention pathway for patients experiencing an ST segment elevation acute coronary syndrome excludes patients with aVR ST elevation. These patients are treated on the non-ST segment elevation acute coronary syndrome pathway, which means that they have a coronary angiogram +/− intervention during their inpatient stay. Patients with non-ST segment elevation acute coronary syndrome have worse outcomes nationally. As such, research is required to demonstrate areas for improvement. This article examines the association between aVR ST segment elevation on the electrocardiogram and significant left main stem, proximal left anterior descending, or 3-vessel coronary artery stenosis in acute coronary syndrome to establish whether the primary percutaneous coronary intervention pathway should be redesigned. Methods Existing literature was searched, and relevant studies were considered and evaluated. Data were collected within local NHS Trusts on patients who had aVR ST segment elevation on the electrocardiogram. The data were analysed, and the findings were compared and synthesised with the literature. Results The study demonstrated a relationship between aVR ST segment elevation and significant disease. However, because of the numbers involved, analysis to demonstrate statistical significance was not possible, with the exception of aVR ST segment elevation and left main stem coronary artery, left anterior descending coronary artery and triple vessel disease, where p<0.05 in the population with left main stem coronary artery occlusion +/− other disease. The study demonstrated that aVR ST segment elevation should be treated as an ST segment elevation acute coronary syndrome equivalent, as it is a high-risk finding. These patients should go immediately to the cardiac catheter laboratory for a primary percutaneous coronary intervention. Conclusion The need for a change in the primary percutaneous coronary intervention pathway was established.
Avaliação da Atenção Primária à Saúde em uma estratégia saúde da família no interior do Pará: Utilização do PCATool-versão Brasil
Authors: De Souza Brenda Ramos , Tavares Jonatas Bezerra , Pinto Girard Cláudia Cristina , Ferreira Ilma Pastana 
Published: August 2019

Motivação:
A motivação para o estudo surgiu do questionamento de como era o desempenho da ESF como parte integrante da APS no município, gerando a primeira hipótese de bom desempenho da ESF e a segunda hipótese de uma ESF com escores não qualificadores.

Método:
Trata-se de um estudo quantitativo, descritivo e transversal, realizado de janeiro a novembro de 2017 com 329 usuários de uma ESF no município de Tucuruí, no estado do Pará, onde foi aplicado um questionário adaptado chamado “Instrumento de Avaliação da Atenção Primária” (PCATool versão Brasil) para a coleta de dados. Os resultados foram analisados a partir do cálculo dos escores de cada atributo, sendo que as médias gerais acima de 6,6 foram consideradas de alto escore e as menores de baixo escore de acordo com a conversão para a escala de Likert.

Resultados:
Os resultados apontaram que a ESF apresentou os seguintes escores qualificadores: 8,44 para o atributo acesso de primeiro contato-utilização e 7,66 para coordenação de sistemas de informação. Seguidos pelos baixos escore de: 5,84 para longitudinalidade, 5,31 para integralidade-serviços disponíveis, 3,93 para o acesso de primeiro contato-acessibilidade, 3,31 para coordenação-integração de cuidados, 2,68 para integralidade dos serviços prestados. Os atributos derivados de APS também foram considerados de baixo escore, cuja orientação familiar obteve escores de 4,66 e orientação comunitária de 4,11. Ao final, o escore geral foi de 5,69 e essencial de 5,31, considerados não qualificadores de APS.

Conclusões:
O baixo escore geral e essencial revelaram a necessidade de mais planejamento dos serviços da ESF com base nos atributos qualificadores da APS, uma vez que são essenciais para um bom desempenho e a busca de maior satisfação dos usuários, fazendo-se necessário o esforço conjunto dos gestores, equipe e comunidade para implementação de novas práticas e mudanças voltadas a qualificação da APS pautadas em iniciativas avaliativas.
A gestão do cuidado e seus desafios no Estado de Goiás: registro do território e integração entre os níveis assistenciais, 2013-2014
Authors: Duarte Lígia Vanessa Silva Cruz , De Souza Marta Rovery , Rosso Claci Fátima Weirich 
Published: August 2019

Motivação:
Estudos enfatizam que ações de gestão do cuidado possibilitam melhorias na continuidade do cuidado, na medida em que reduzem barreiras. O presente estudo teve como objetivo avaliar a gestão do cuidado na APS utilizando os parâmetros avaliados pelo PMAQ - AB no Estado de Goiás.

Método:
Estudo transversal que avaliou os resultados do PMAQ-AB, em 2013-2014. Foram utilizados dados secundários extraídos do banco de dados da Avaliação Externa do PMAQ-AB.

Resultados:
Os resultados desse estudo permitem afirmar que existe fragilidade no que se refere a um registro consistente do território, padronizações para condutas, programação da agenda, oferta de consultas, a classificação de risco e a definição de fluxos bem definidos do usuário dentro do sistema, nas unidades de saúde na Atenção Básica do estado de Goiás.

Conclusões:
Os resultados encontrados poderão subsidiar a reflexão dos gestores quanto à identificação de problemas na coordenação, fluxo e continuidade da atenção.
Interaction of Cortical and Amygdalar Synaptic Input Modulates the Window of Opportunity for Information Processing in the Rhinal Cortices
Authors: Willems Janske G. P. , Wadman Wytse J. , Cappaert Natalie L. M. 
Published: August 2019

AbstractThe perirhinal (PER) and lateral entorhinal (LEC) cortex function as a gateway for information transmission between (sub)cortical areas and the hippocampus. It is hypothesized that the amygdala, a key structure in emotion processing, can modulate PER-LEC neuronal activity before information enters the hippocampal memory pathway. This study determined the integration of synaptic activity evoked by simultaneous neocortical and amygdala electrical stimulation in PER-LEC deep layer principal neurons and parvalbumin (PV) interneurons in mouse brain slices. The data revealed that both deep layer PER-LEC principal neurons and PV interneurons receive synaptic input from the neocortical agranular insular cortex (AiP) and the lateral amygdala (LA). Furthermore, simultaneous stimulation of the AiP and LA never reached the firing threshold in principal neurons of the PER-LEC deep layers. PV interneurons however, mainly showed linear summation of simultaneous AiP and LA inputs and reached their firing threshold earlier. This early PV firing was reflected in the forward shift of the evoked inhibitory conductance in principal neurons, thereby creating a more precise temporal window for coincidence detection, which likely plays a crucial role in information processing.
Common fixed points for alpha-psi-phi-contractions in generalized metric spaces
Authors: La Rosa Vincenzo , Vetro Pasquale 
Published: August 2019

We establish some common fixed point theorems for mappings satisfying an α-ψ-ϕ-contractive condition in generalized metric spaces. Presented theorems extend and generalize manyexisting results in the literature.
Erratum to “Common fixed points for α-ψ-φ-contractions in generalized metric spaces”
In Example 1 of our paper [V. La Rosa, P. Vetro, Common fixed points for α-ψ-ϕ-contractions in generalized metric spaces, Nonlinear Anal. Model. Control, 19(1):43–54, 2014] a generalized metric has been assumed. Nevertheless some mistakes have appeared in the statement. The aim of this note is to correct this situation.
Comparison of spatial classification rules with different conditional distributions of class label
Authors: Stabingis Giedrius , Dučinskas Kęstutis , Stabingienė Lijana 
Published: August 2019

In this paper spatial classification rules based on Bayes discriminant functions are considered. The novelty of this work is that the statistical supervised classification method is improved by extending the influence of spatial correlation between observation to be classified and training sample. Such methods are used for data containing spatially correlated noise. Method accuracy is tested experimentally on artificially corrupted images. This classification rule with distance based conditional distribution for class label shows advantage against other classification rule ignoring such influence and against other commonly used supervised classification methods.
Analysis of a duopoly game with heterogeneous players participating in carbon emission trading
Authors: Zhao Lingrui , Zhang Jixiang 
Published: August 2019

In this paper, a price competition model with two heterogeneous players participating in carbon emission trading is formulated. The stable conditions of the equilibrium points of this system are discussed. Numerical simulations are used to show bifurcation diagrams, strange attractors, and sensitive dependence on initial conditions. We observe that the speed of adjustment of bounded rational player may change the stability of the Nash equilibrium and cause the system to behave chaotically. In addition, we find that the price of emission permits plays an important role in the duopoly game. The chaotic behavior of the system has been stabilized on the Nash equilibrium point by applying delay feedback control method.
Output feedback control of nonlinear systems with uncertain ISS/iISS supply rates and noises
Authors: Yu Xin , Liu Guohai 
Published: August 2019

This paper considers the problem of global output feedback control for a class of nonlinear systems with inverse dynamics. The main contribution of paper is that: For the inverse dynamics with uncertain ISS/iISS supply rates, and the systems being disturbed by L2 noises, we construct a reduced-order observer-based output feedback controller, which drives the output of system to zero and maintain other closed-loop signals bounded. Finally, a simulation example shows the effectiveness of the control scheme.
Robust optimal H-infinity control for irregular buildings with AMD via LMI approach
Authors: Li Zhijun , Wang Sheliang 
Published: August 2019

In view of the numerous uncertainties of seismic disturbances and structural parameters, the irregular building structure is uncertain. In this paper, a new robust optimal H∞ controller for irregular buildings is designed to guarantee the robust stability and performance of the closed-loop system in the presence of parameter uncertainties. Such a control method can provide a convenient design procedure for active controllers to facilitate practical implementations of control systems through the use of a quadratic performance index and an efficient solution procedure based on linear matrix inequality (LMI). To verify the effectiveness of the control method, a MDOF (multipledegree-of-freedom) eccentric building structure with two active mass damper (AMD) systems on the orthogonal direction of the top storey subjected to bi-directional ground motions is analyzed. In the simulation, the active control forces of the AMD systems are designed by the robust optimal H∞ control algorithm, and the structural system uncertainties are assumed in the system and input matrices. The simulation results obtained from the proposed control method are compared with those obtained from traditional H∞ control method, which shows preliminarily that the performance of robust optimal H∞ controllers is remarkable and robust. Therefore, the robust optimal H∞ control method is quite promising for practical implementations of active control systems on seismically excited irregular buildings.
Why do not polyphenols of red wine protect against the harmful effects of alcohol in alcoholism?
Authors: Blázovics A. , Fébel H. , Bekő G. , Kleiner D. , Szentmihályi K. , Sárdi É. 
Published: August 2019

The effect of polyphenolic bioactive substances, especially resveratrol (12.03 mg l−1), of an often consumed Hungarian red wine was investigated in a short term rat experiment. Male young Wistar albino rats were treated with high volumes of red wine (matching one bottle of wine/day for a 85 kg man) (N=5) and another alcoholic drink of the same alcohol concentration (N=5), corresponding to the circumstances of alcoholism, and 5 rats were in the control group. A total of 7 routine laboratory parameters were measured from the sera by kits.
The changes of redox homeostasis (H-donor activity, induced chemiluminescence, diene-conjugates, GSHPx) were studied in blood plasma and/or in liver homogenates by spectrophotometric and luminometric methods. Transmethylation property of the liver was measured by overpressured layer chromatography (OPLC) technique. It was proven with in vitro OPLC analytical study that resveratrol reacted with methyl groups, and resveratrol was demonstrated to influence transmethylation processes as well as redox homeostasis. Red wine compounds do not protect from the harmful effects of alcohol, and even by high doses of resveratrol, the liver further deteriorates and the negative effect of alcohol increases. It has been confirmed that high doses of resveratrol do not provide protection against liver damage in those suffering from alcoholism.
POLICY IMPLICATION OF SINGLE CANDIDATES IN REGIONAL HEAD ELECTION ON VOTER PARTICIPATION IN TASIKMALAYA DISTRICT
Authors: Engkus Engkus , Suparman Nanang , Trisakti Fadjar , Lestari Firda 
Published: August 2019

The main problem in this study is that voter participation in the election to the regions in Tasikmalaya Regency declined. This is possible because of the absence of candidates who have great potential to compete with the single candidate, the existence of a legal vacuum (Rechtvacum) with weak regulations regarding regional elections followed by single candidates which have implications for planned delays in the election, political. This study uses a quantitative approach with Associative method. The calculation results obtained by calculating the dimensions of size and purpose, resources, character of the implementing agent, disposition, communication, and environment of the Single Candidate Determination Policy in the Election of Regional Heads on Voter Participation in Tasikmalaya District have a significant influence. Thus it is concluded that there are still not optimal indicators from the dimensions of policy implementation such as the character of the implementing agency that directly affects participation of the community, then in communication and the way the implementer gives an attitude in accepting the results of implementation that are not in accordance with what the community feels