bluuebunny/crossref_metadata_2025_split huggingface dataset:
lncRNA CASC11 promotes cancer cell proliferation in bladder cancer through miRNA‐150
Authors: Luo Huarong , Xu Chengdang , Le Wei , Ge Bujun , Wang Tianru 
Published: March 2019

AbstractLong noncoding RNAs (lncRNAs) CASC11 is an oncogenic lncRNA in gastric cancer and colorectal cancer. Our study aimed to investigate the role of lncRNA CASC11 in bladder cancer. In this study we showed that plasma lncRNA CASC11 was upregulated, while plasma miRNA‐150 was downregulated in patients with early‐stage bladder cancer than in healthy controls. Altered expression of plasma lncRNA CASC11 and miRNA‐150 separated patients with bladder cancer from healthy controls. lncRNA CASC11 expression was inversely correlated with miRNA‐150 expression in patients with bladder cance but not in healthy controls. Overexpression of lncRNA CASC11 mediated the inhibition of miRNA‐150 expression in cancer cells, while miRNA‐150 overexpression did not significantly alter lncRNA CASC11 expression. lncRNA CASC11 overexpression promoted, while miRNA‐150 overexpression inhibited cancer cell proliferation. miRNA‐150 also attenuated the enhancing effects of lncRNA CASC11 overexpression on cancer cell proliferation. However, overexpression of lncRNA CASC11 showed no significant effects on cancer cell migration and invasion. Therefore, lncRNA CASC11 may promote cancer cell proliferation in bladder cancer, and the actions of lncRNA CASC11 are likely through miRNA‐150.
DNA methylation‐based diagnostic and prognostic biomarkers of nonsmoking lung adenocarcinoma patients
Authors: Zhang Xiaoming , Gao Chundi , Liu Lijuan , Zhou Chao , Liu Cun , Li Jia , Zhuang Jing , Sun Changgang 
Published: March 2019

AbstractCurrently, there are few studies on patients with nonsmoking lung adenocarcinoma, and the pathogenesis is still unclear. The role of DNA methylation in the pathogenesis of cancer is gradually being recognized. The purpose of this study was to determine the abnormal methylation genes and pathways involved in nonsmoking lung adenocarcinoma patients. Gene expression microarray data (GSE10072, GSE43458) and gene methylation microarray data (GSE62948) were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes were obtained through GEO2R. Next, we analyzed the function and enrichment of the selected genes using Database for Annotation, Visualization, and Integrated Discovery. The protein‐protein interaction (PPI) networks were constructed using the Search Tool for the Retrieval of Interacting Genes database and visualized in Cytoscape. Finally, we performed module analysis of the PPI network using Molecular Complex Detection. And we obtained 10 hub genes by Cytoscape Centiscape. We analyzed the independent prognostic value of each hub gene in nonsmoking nonsmall cell lung cancer patients through Kaplan‐Meier plotter. Seven hub genes (CXCL12, CDH1, CASP3, CREB1, COL1A1, ERBB2, and ENO2) were closely related to the overall survival time. This study provides an effective bioinformatics basis for further understanding the pathogenesis and prognosis of nonsmoking lung adenocarcinoma patients. Hub genes with prognostic value could be selected as effective biomarkers for timely diagnosis and prognostic of nonsmoking lung adenocarcinoma patients.
Identification of potential key genes associated with osteosarcoma based on integrated bioinformatics analyses
Authors: Hu Guangbing , Cheng Zhian , Wu Zizhuo , Wang Hanyu 
Published: March 2019

AbstractDue to high rates of metastasis and poor clinical outcomes for patients, it is important to study the pathomechanisms of osteosarcoma. However, due to the fact that osteosarcoma shows significant interindividual variation and high heterogeneity, the identification of differentially expressed genes (DEGs) at the population level cannot answer many important questions related to osteosarcoma tumorigenesis. Therefore, a new strategy to identify dysregulated genes in osteosarcoma samples is required. The aim of this study was to improve our understanding of osteosarcoma pathogenesis by identifying genes with universal aberrant expression in osteosarcoma samples. Because the relative expression ordering of genes is stable in normal bone tissues but is disrupted in osteosarcoma tissues, we used the RankComp algorithm to identify DEGs in normal and osteosarcoma tissue samples. We then calculated the dysregulation frequency for each gene. Genes with deregulation frequencies above 80% were deemed to be universal DEGs. Next, coexpression, pathway enrichment, and protein‐protein interaction network analyses were performed to characterize the functions of these genes. From 188 samples of osteosarcoma obtained from four datasets measured on different platforms, 51 universal DEGs were identified, including 4 universally upregulated genes and 47 universally downregulated genes. Genes that were differentially coexpressed with these universal DEGs were found to be enriched in 46 cancer‐related pathways. In addition, functional and network analyses showed that genes with high dysregulation frequencies were involved in cancer‐related functions. Thus, the commonly aberrant genes identified in osteosarcoma tissues may be important targets for osteosarcoma diagnosis and therapy.
Microstructure and material properties of hind wings of a bamboo weevil Cyrtotrachelus buqueti (Coleoptera: Curculionidae)
Authors: Li Xin , Guo Ce 
Published: March 2019

AbstractWings of flying insects, as representative biomaterials, are composed of a flexible membrane and a stiff vein structure that are prone to bending and deformation under aerodynamic forces. Therefore, we must investigate the application value of insect wings in the field of engineering design from the perspective of bionics, which is a new challenge. In this study, we measured the mechanical properties of the hind wings of Cyrtotrachelus buqueti including “dried” and “fresh” samples. The wing membrane samples were prepared by carefully cutting the hind wings into 2.0 mm by 8.0 mm rectangular segments using a gauge. As the major wing veins are the main loading units under aerodynamic forces, we also separated them from the wings as a kind of investigative specimen. The wing membranes were adhered to a specially designed paper fixture and the mechanical properties of the wing veins and membranes were evaluated using a tensile testing machine. We observed the microstructure of the samples using a scanning electron microscope and accurately measured the thicknesses of desired the wing membranes and veins. The results show that there is a difference in the mechanical properties of the two samples. The elastic modulus and Poisson's ratios vary over the region in hind wing, so we can conclude that the wing membrane is an anisotropic and non‐uniform material.
Effect of gluten‐free diet and compliance on quality of life in pediatric celiac disease patients
Authors: Chellan Deepak , Muktesh Gaurav , Vaiphei Kim , Berry Neha , Dhaka Narendra , Sinha Saroj Kant , Thapa Babu Ram , Kochhar Rakesh 
Published: March 2019

BackgroundQuality of life (QOL) in children with celiac disease (CD) has been sparsely studied.AimsWe aimed to study QOL in pediatric CD and the effect of a gluten‐free diet (GFD) in a North Indian population.MethodsQOL was assessed at baseline and 6 months after GFD using a pediatric symptom checklist (PSC) score. The effect of GFD was assessed using a CD‐specific questionnaire on domains such as dietary compliance, parental behavior and perceptions, children's feeling, and difficulty identifying gluten‐free foods.ResultsA total of 60 CD children (age 6.03 ± 0. 42 years, range: 2–12 years, M:F 2:1) were prospectively enrolled. The median PSC score at baseline was 11.5 (2–35), which showed a statistically significant improvement after GFD to 2.5 (0–34) (P < 0.001). Significant concerns regarding specific domains emerged: difficulty in maintaining GFD 26.2%, at school 14.3%, at parties 43.2%, poor taste 11.4%, special diet a burden 28.5%, felt left out at school or friend's home 40.9%, felt different from other kids 40.9%, felt embarrassed to bring GFD to parties 54.6%, felt angry about following a special diet 56.8%, felt not invited out for meals because of CD 13.6%, and difficulty determining if food available was gluten free in 75%.ConclusionGFD has a significant impact on emotional, behavioral, and psychosocial domains in children with CD. Proper labeling of commercially available food items, counseling, and patient support groups are the need of the hour.
Characterization of Sub‐1 cm Breast Lesions Using Radiomics Analysis
Authors: Gibbs Peter , Onishi Natsuko , Sadinski Meredith , Gallagher Katherine M. , Hughes Mary , Martinez Danny F. , Morris Elizabeth A. , Sutton Elizabeth J. 
Published: March 2019

BackgroundSmall breast lesions are difficult to visually categorize due to the inherent lack of morphological and kinetic detail.PurposeTo assess the efficacy of radiomics analysis in discriminating small benign and malignant lesions utilizing model free parameter maps.Study TypeRetrospective, single center.PopulationIn all, 149 patients, with a total of 165 lesions scored as BI‐RADS 4 or 5 on MRI, with an enhancing volume of <0.52 cm3.Field Strength/SequenceHigher spatial resolution T1‐weighted dynamic contrast‐enhanced imaging with a temporal resolution of ~90 seconds performed at 3.0T.AssessmentParameter maps reflecting initial enhancement, overall enhancement, area under the enhancement curve, and washout were generated. Heterogeneity measures based on first‐order statistics, gray level co‐occurrence matrices, run length matrices, size zone matrices, and neighborhood gray tone difference matrices were calculated. Data were split into a training dataset (~75% of cases) and a test dataset (~25% of cases).Statistical TestsComparison of medians was assessed using the nonparametric Mann–Whitney U‐test. The Spearman rank correlation coefficient was utilized to determine significant correlations between individual features. Finally, a support vector machine was employed to build multiparametric predictive models.ResultsUnivariate analysis revealed significant differences between benign and malignant lesions for 58/133 calculated features (P < 0.05). Support vector machine analysis resulted in areas under the curve (AUCs) ranging from 0.75–0.81. High negative (>89%) and positive predictive values (>83%) were found for all models.Data ConclusionRadiomics analysis of small contrast‐enhancing breast lesions is of value. Texture features calculated from later timepoints on the enhancement curve appear to offer limited additional value when compared with features determined from initial enhancement for this patient cohort.Level of Evidence: 4Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2019;50:1468–1477.
Reliable noise modeling of GaN HEMTs for designing low‐noise amplifiers
Authors: Jarndal Anwar , Hussein Ahmed , Crupi Giovanni , Caddemi Alina 
Published: March 2019

AbstractA reliable modeling procedure is developed for extracting an equivalent circuit able to reproduce the small‐signal and noise performance of the gallium nitride (GaN) high‐electron mobility transistor (HEMT) technology. The main advantages of this model are its simplicity and straightforward extraction based on only pinch‐off scattering (S‐) parameter measurements. The validity of the achieved model is verified by the good agreement between high‐frequency experiments and simulations for three devices with different sizes. The model reliability is further confirmed by the observed good scaling of the extracted parameters. The same model is demonstrated by designing and simulating a broadband low‐noise amplifier (LNA) for 5G applications.
Tachycardia cycle length alternans caused by alternate conduction velocity on the slow conduction zone in a postoperative scar‐related atrial tachycardia
Authors: Su Chen , Liu Menghui , Ma Yuedong , Wang Lichun 
Published: March 2019

AbstractThe underlying mechanism for stable beat‐to‐beat cycle length variability (CL alternans) in scar‐related atrial tachycardia (AT) had not been elucidated clearly. We described a case with postoperative dual‐loop reentrant AT in right atrium. When the loop depended on cavo‐tricuspid isthmus was blocked by ablation, the AT transformed into a CL alternate tachycardia. High density and resolution mapping revealed that the CL alternans was caused by the alternate conduction velocities at the slow conduct region. A further ablation line was created from the slow conduction zone to the inferior vena cave, and afterward no AT was inducible.
Backward and forward drift trajectories of sea ice in the northwestern Arctic Ocean in response to changing atmospheric circulation
Authors: Lei Ruibo , Gui Dawei , Hutchings Jennifer K. , Wang Jia , Pang Xiaoping 
Published: March 2019

AbstractTo track sea ice motion, four ice‐tethered buoys were deployed at 84.6°N and 144.3°W, 87.3°N and 172.3°W, 81.1°N and 157.4°W, and 82.8°N and 166.5°W in summers of 2008, 2010, 2014, and 2016, respectively. In addition, the remote sensed ice motion product provided by National Snow and Ice Data Center was used to reconstruct backward and forward ice drifting trajectories from the buoy deployment sites during 1979–2016. Sea ice in the central Arctic Ocean in late summer is trending to have travelled from lower latitudes, and to be advected to the region more involved in the Transpolar Drift Stream (TDS) during 1979–2016. The strengthened TDS has played a crucial role in Arctic sea ice loss from a dynamic perspective. The trajectory of ice is found to be significantly related to atmosphere circulation indices. The Central Arctic Index (CAI), defined as the difference in sea level pressure between 84°N, 90°W and 84°N, 90°E, can explain 34–40% of the meridional displacement along the backward trajectories, and it can explain 27–40% of the zonal displacement along the forward trajectories. The winter Beaufort High (BH) anomaly can explain 18–27% of the zonal displacement. Under high positive CAI values or high negative winter BH anomalies, floes from the central Arctic tended to be advected out of the Arctic Ocean through Fram Strait or other marginal gateways. Conversely, under high negative CAI values or high positive winter BH anomalies, ice tended to become trapped within a region close to the North Pole or it drifted into the Beaufort Gyre region. The long‐term trend and spatial change in Arctic surface air temperature were more remarkable during the freezing season than the melt season because most energy from the lower troposphere is used to melt sea ice and warm the upper ocean during summer.
Aligning content rendering resolution and feature size with display capability in near‐eye display systems
Authors: Hoffman David M. , McKenzie Chris , Koprowski Brion , Iqbal Asif , Balram Nikhil 
Published: March 2019

AbstractIn order to create a satisfying experience with near‐eye displays, the content must be adapted to be legible on the display used. New displays are using subpixel arrangements that can limit the minimum resolvable feature size to something greater than with the conventional RGB stripe arrangement. We conducted an experiment to measure the minimum and preferred size of text in two virtual reality (VR) displays systems and find that the text size is display limited. We then measure several displays with different pixel arrangements to determine whether the subpixel arrangement could impact legibility. We propose several Fourier metrics that can be computed from the measured data to categorize the capability of the display and describe a framework for selecting the appropriate content from a set of discrete tiers.
A nomogram for predicting recurrence after complete resection for thymic epithelial tumors based on the TNM classification: A multi‐institutional retrospective analysis
Authors: Yun Jae Kwang , Lee Geun Dong , Kim Hyeong Ryul , Kim Dong Kwan , Zo Jae Il , Shim Young Mog , Kang Chang Hyun , Kim Young Tae , Paik Hyo Chae , Chung Kyoung Young ,   other members of the Korean Association for Research on the Thymus (KART).
Published: March 2019

AbstractObjectivesThis study aimed to compare the predictive ability between the Masaoka‐Koga (M‐K) staging system and the 8th TNM staging system for the recurrence of thymic epithelial tumors (TETs). In addition, a nomogram was developed on the basis of the proposed TNM classification to predict individual recurrence rate.MethodsA retrospective study was performed on 445 patients who underwent complete resection (R0) of TETs between January 2000 and February 2013. Concordance index (C‐index) was used as a statistical indicator to quantify the prediction power of the prediction models.ResultsIn multivariate analysis, tumor stage and WHO classification were independent recurrence factors in a predictive model on the basis of M‐K and TNM stage. The TNM model showed higher C‐index than the M‐K model (0.837 vs 0.817). The nomogram, on the basis of the TNM model, revealed a highly predictive performance, with a bootstrap‐corrected C‐index of 0.85 (95% CI, 0.76 to 0.93).ConclusionsA predictive model based on the 8th TNM stage was slightly better than that based on M‐K stage with respect to recurrence after R0 of TETs. The proposed nomogram could be applied to estimate the individual recurrence rate and make decisions for proper surveillance.
Multi‐scale Gaussian/Haar wavelet strategies coupled with sub‐window factor analysis for an accurate alignment in nontargeted metabolic profiling to enhance herbal origin discrimination capability
Authors: He Min , Hong Liang , Zhou Yu 
Published: March 2019

AbstractMetabolic dataset can provide an overview of different herbal origin, which is conducted by some statistical procedures. Such results often deviate to a certain degree, due to peaks shifts in chromatographic signals. In order to solve this problem, an improved algorithm of combining sub‐window factor analysis with the mass spectrum information is proposed. The algorithm uses a peak detection approach derived either from multi‐scale Gaussian function or Haar wavelet to locate the peaks with different application scope; the candidate drift points at each peak are estimated by Fast Fourier transform cross correlation; Specifically, the best drift points at each candidate peaks are confirmed by sub‐window factor analysis and mass spectrum information in nontargeted metabolic profiling. Finally, the peak regions were aligned against a reference chromatogram, and the non‐peak regions were used linear interpolation. The chromatographic signals of 30 Bupleurum samples were aligned as an illustration of this algorithm, and they could be well distinguished using some statistical procedures. The result demonstrates that the presented method is stronger than other mass‐spectra based algorithms, when facing the alignment of some co‐eluted peaks.
Sol‐gel technique for the preparation of β‐cyclodextrin gold nanoparticles as chiral stationary phase in open‐tubular capillary electrochromatography
Authors: Jiang Zhen , Qu Jialin , Tian Xiangge , Huo Xiaokui , Zhang Jianbin , Guo Xingjie , Fang Linlin 
Published: March 2019

AbstractA novel open‐tubular capillary electrochromatography column coated with β‐cyclodextrin was prepared using the sol‐gel technique. In the sol‐gel approach, owing to the three‐dimensional network of sol‐gel and the strong chemical bond between the stationary phase and the surface of capillary columns, good chromatographic characteristics and unique selectivity in separating enantiomers were shown. The influences of capillary inner diameter, coating time, organic modifier, buffer pH, and buffer concentration on separation were investigated. The sol‐gel‐coated β‐cyclodextrin column has shown improved enantioseparation efficiency of chlorphenamine, brompheniramine, pheniramine, zopiclone in comparison with the sol‐gel matrix capillary column. The migration time relative standard deviation of the separation of the enantiomers was less than 0.89% over five runs and 2.9% from column to column. This work confirmed that gold nanoparticles are promising electrochromatographic support to enhance the phase ratio of open‐tubular capillary electrochromatography column in capillary electrochromatography.
Examination of Treatment Effects on Hazardous Drinking Among Service Members With Posttraumatic Stress Disorder
Authors: Dondanville Katherine A. , Wachen Jennifer Schuster , Hale Willie J. , Mintz Jim , Roache John D. , Carson Cody , Litz Brett T. , Yarvis Jeffrey S. , Young‐McCaughan Stacey , Peterson Alan L. , Resick Patricia A. ,   for the STRONG STAR Consortium
Published: March 2019

AbstractPosttraumatic stress disorder (PTSD) and alcohol use disorder are frequently comorbid and present significant treatment challenges. Unfortunately, since the September 11, 2001, terrorist attacks in the United States, the rates of PTSD and hazardous drinking among active duty service members have increased significantly. Previous research on PTSD has typically excluded participants with current substance abuse. However, there is some research examining independent treatments for PTSD and substance abuse provided consecutively, concurrently, or as enhancements to other treatment. The current study examined the association between current hazardous drinking and PTSD treatment among 108 active duty service members with PTSD in a randomized controlled trial of group cognitive processing therapy and group present‐centered therapy. Total scores above 8 on the Alcohol Use Disorders Identification Test defined hazardous alcohol use. At baseline, 25.0% of the sample was categorized as hazardous drinkers, and the hazardous and nonhazardous drinking groups did not differ in PTSD symptom severity, F(1, 106) = 0.08, p = .777, d = 0.06. Over the course of treatment, the two groups also did not differ significantly in PTSD symptom severity change on the PTSD Checklist, F(1, 106) = 1.20, p = .280, d = 0.33. Treatment for PTSD did not exacerbate hazardous drinking, and the hazardous drinking group showed significant reductions in drinking following PTSD treatment. Limitations and implications for treatment considerations are discussed.
Kinetics of nonisothermal reduction and carburization of WO3─NiO nano‐composite powders by CO─CO2
Authors: Mohammadzadeh Hurieh , Rezaie HamidReza , Barati Mansoor , Yu Dawei , Samim Hamid Reza 
Published: March 2019

AbstractThe kinetics of simultaneous reduction and carburization of WO3─NiO nanocomposite powders by CO/CO2 was studied using a nonisothermal thermogravimetric analysis. The experiments were carried out at heating rates between 5 and 15°C/min, showing that the thermochemical processes can be divided into four steps, each dominated by a reaction, as following: NiO → Ni, WO3 → WO2, WO2 → W, and W → WC. The apparent activation energy for each step was obtained based on the Flynn‐Wall‐Ozawa isoconversional method for the individual steps, and the kinetic model was assessed by fitting master plots of various kinetic models for these steps at different heating rates. The Avrami‐Erofeev kinetic model was found to fit to the third and fourth steps and main part of the first, and the geometric contracting model fitted the best for the second step. Changing the heating rate did not affect the master plots of the third step. However, for the first step, increasing the heating rate made the Avrami‐Erofeev model the best‐fitting correlation and also for the second step the matching model changed at the highest heating rate (15°C/min) from a two‐dimensional contracting model (cylindrical particles) to a three‐dimensional contracting model (spherical particles).