bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine Structure and Biochemical Mechanisms Underlying Nigrostriatal Inclusions and Cell Death after Proteasome Inhibition
Authors: Fornai Francesco , Lenzi Paola , Gesi Marco , Ferrucci Michela , Lazzeri Gloria , Busceti Carla L. , Ruffoli Riccardo , Soldani Paola , Ruggieri Stefano , Alessandrì Maria G. , Paparelli Antonio 
Published: April 2018

Mutation of genes encoding for various components of a metabolic pathway named the ubiquitin-proteasome system (UP) leads to inherited forms of Parkinson's disease (PD), whereas various components of the UP are constantly present within neuronal inclusions, Lewy bodies, that characterize most genetic and sporadic forms of PD. It has been hypothesized that impairment of this metabolic pathway might be a common mechanism for the onset of PD, and a recent study demonstrated a dysfunction of the UP system within the substantia nigra of patients affected by sporadic PD. In search for the mechanisms underlying the selective toxicity for nigral neurons after inhibition of the UP system, we explored the selective effects after striatal microinfusions of lactacystin or epoxomycin and potential retrograde changes within the ipsilateral substantia nigra. We found that neurotoxicity was selective for striatal dopamine (DA) components and led to retrograde apoptosis within nigral DA cells, which developed neuronal inclusions staining for antigens of the UP system. We found the same ultrastructural features characterizing inclusions obtainedin vivoandin vitroafter UP inhibition.In vivo, lactacystin-epoxomycin-induced toxicity was suppressed by inhibiting DA synthesis. Similarly,in vitroinclusions and apoptosis were prevented by reducing endogenous DA. On the other hand, toxicity of proteasome inhibition was enhanced by drugs augmenting DA availability:l-3,4-dihydroxyphenylalanine, monoamine oxidase blockers, and DA β-hydroxylase blockers.These findings demonstrate that impairment of the UP system produces cell death and neuronal inclusions selectively for DA-containing neurons that depend on the occurrence of endogenous DA.
Next-Generation Sequencing of the Complete Mitochondrial Genome of the Endangered Species Black Lion Tamarin Leontopithecus chrysopygus (Primates) and Mitogenomic Phylogeny Focusing on the Callitrichidae Family
Authors: de Freitas Patrícia Domingues , Mendez Fernando Luis , Chávez-Congrains Karla , Galetti Pedro Manoel , Coutinho Luiz Lehmann , Pissinatti Alcides , Bustamante Carlos Daniel 
Published: April 2018

Abstract
We describe the complete mitochondrial genome sequence of the Black Lion Tamarin, an endangered primate species endemic to the Atlantic Rainforest of Brazil. We assembled the Leontopithecus chrysopygus mitogenome, through analysis of 523M base pairs (bp) of short reads produced by next-generation sequencing (NGS) on the Illumina Platform, and investigated the presence of nuclear mitochondrial pseudogenes and heteroplasmic sites. Additionally, we conducted phylogenetic analyses using all complete mitogenomes available for primates until June 2017. The single circular mitogenome of BLT showed organization and arrangement that are typical for other vertebrate species, with a total of 16618 bp, containing 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes, and 1 non-coding region (D-loop region). Our full phylogenetic tree is based on the most comprehensive mitogenomic dataset for Callitrichidae species to date, adding new data for the Leontopithecus genus, and discussing previous studies performed on primates. Moreover, the mitochondrial genome reported here consists of a robust mitogenome with 3000X coverage, which certainly will be useful for further phylogenetic and evolutionary analyses of Callitrichidae and higher taxa.
The draft provisions on antitrust fines in the Commission’s ECN+ Proposal
Authors: Thomas Stefan , Dueñas Manuel 
Published: April 2018

Abstract
On 22 March 2017, the Commission released its Proposal for a directive to empower the competition authorities of the Member States to be more effective enforcers (COM(2017) 142 final). With this effort to harmonise national public enforcement regimes, the Commission enters uncharted territory. Effectiveness is deemed to be fostered by the introduction of the economic entity doctrine as a unitary sanctioning concept throughout the Member States. As a complementing measure, the Proposal prescribes a more coherent standard for leniency in the European Competition Network. The present article ventures to evaluate these remedies. A preliminary hypothesis is that the Commission’s conviction of the economic entity doctrine to become the gold standard for antitrust enforcement is possibly based on tenuous ideas of effectiveness. Moreover, the introduction of a 10 % fine cap for any National Competition Authority irrespective of the size of the Member State can lead to highly disparate relative fining powers throughout the internal market. As to the leniency aspect, the present article will attempt to assess whether the Proposal taps the full potential for enhancement. As an alternative to the Commission’s suggestions the article elaborates on a one-stop-shop leniency principle. Such would go beyond the current Proposal in that it would render multiple leniency filings obsolete within the EU.
DETERMINATION OF CONCRETE VAULT THICKNESS OF NEAR SURFACE DISPOSAL FOR RADIOACTIVE WASTE AT SERPONG NUCLEAR AREA
Authors: Sucipta Sucipta , Suhartono Suhartono 
Published: April 2018

In order to support and complement the radioactive waste management facilities in Indonesia, BATAN will build a demonstration disposal facility in Serpong Nuclear Area (SNA). Demonstration disposal that will be built is Near Surface Disposal (NSD) type. Engineered vault for NSD is reinforced concrete. The calculations for determining the thickness of NSD concrete vault is based on the conceptual design as the result of the placement optimization of demonstration disposal that takes into account the inventory of radioactive waste and environmental geology conditions of the site at Serpong Nuclear Area. The thickness of the vault in this paper is focused on its ability to withstand radiation from stored waste so that workers or people who are around the disposal facility is safe with maximum radiation dose limit rate of 0.3 μSv / h. The calculation is performed with the aid of MicroShield 7:02 and Rad Pro Calculator Version 3:26 software. From the calculation so that the dose rate at the outer surface of the vault to be 0.3 μSv / h, required walls made of concrete with a density of 2:35 g / cm3 is 62.8 cm thickness.
Patent duktus arteriozuslu bebeklerde konservatif tedavinin sonuçları
Authors: KARPUZ Derya , ÇELİK Yalçın , BOZLU Gülçin , KARA Baki , GİRAY Dilek , HALLIOĞLU Olgu 
Published: April 2018

Amaç: Bu çalışmada hastanemizde izlenen prematürelerde gebelik haftasına göre patent duktus arteriosus (PDA) sıklığının, kendiliğinden kapanma oranlarının ve kapanmayanlarda oral tedavi etkinliğinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Yenidoğan yoğun bakım ünitemizde 2013-2016 yılları arasında PDA tanısıyla izlenen hastalar retrospektif olarak tarandı. Kardiyak incelemede yalnızca PDA tanısı konulan 231 hasta, gebelik haftasına göre gruplara ayrılarak ekokardiyografik ölçümleri karşılaştırıldı. Ekokardiyografik değerlendirme doğumdan sonra ortalama 4.6±15 günlük iken uygulandı. Hastaların demografik verilerin yanı sıra PDA boyutu, sol atrium/aorta oranı, PDA gradienti, sol ventrikül fonksiyonları değerlendirildi. Bulgular: Yenidoğan yoğun bakım ünitemize izlenen hastalar arasında PDA sıklığı %10,8 (231/2127 hasta) idi. Hastaların 41’inde (%17.7) anlamlı PDA vardı, bu hastalarda duktus çapı ortalamaları 2.5±0.5 ve sol atrium/aorta oranı 1.37±0.15 bulundu. Kapanma olmayan ve hemodinamik olarak anlamlı PDA’sı olan 8 (%19.5) hastaya oral ibuprofen verildi. Kapatma verilen hastaların tümünün gestasyonel yaşı &lt;32 hafta ve &lt;1500gr idi. Yalnızca bir hastada cerrahi kapatma gerekti. Sonuç: Günümüzde preterm bebeklerde hangi bebeğe ve ne zaman PDA kapatma tedavisi verilmesi gerektiği önemli bir tartışma konusudur. Yenidoğan yoğun bakım ünitesinde PDA’sı olan prematüre bebeklere konservatif yaklaşım uygulanmaktadır ve sonuçlarımıza bakıldığında konservatif yaklaşımla sadece bir hastada cerrahi gereksinim olmuştur. Buna göre PDA’sı olan prematüre bebeklerde tedavi kararı verirken acele edilmemesi ve yakın izlemin yapılmasını önerebiliriz.
Koroner arter bypass cerrahisi sonrası erken kardiyak komplikasyonların tanı ve tedavisinde ekokardiyografinin rolü
Authors: Ovalı Cengiz , Şahin Aykut 
Published: April 2018

Amaç: Koroner arter hastalığı tüm dünyada ve ülkemizde ölümün en önemli sebebidir. Koroner arter by-pass cerrahisi uygulanan hastaların risk düzeyi arttıkça postoperatif komplikasyonlarda artmaktadır. Bu çalışmanın amacı; koroner arter by-pass cerrahisi uygulanan hastalarda postoperatif erken dönemde oluşan kardiyak komplikasyonların tanı ve tedavisinde ekokardiyografinin rolünü araştırmaktır. Gereç ve Yöntem: Bu amaçla Haziran 2016 – Haziran 2017 tarihleri arasında kliniğimizde koroner arter by-pass cerrahisi uygulanan 53 hasta postoperatif dönemde 1 (bir) hafta boyunca günlük ekokardiyografik değerlendirme ile takip edildi.Bulgular: Hastalarda en az drenaj 300 cc iken en fazla 1200 cc (ortalama 460 cc) oldu. Perikardiyal efüzyon 1.günde 28 hastada, 2.günde 6 hastada, 3. günde ise sadece 1 hastada tespit edildi. İki hastada postop 0. gün kalbin ön yüzünde ciddi bası oluşturan ve hemodinamiyi etkileyen perikardiyal tamponat vardı. Bu hastalar yeniden operasyona alınarak hemodinamisi stabil hale getirildi.Sonuç: Koroner bypass yapılan hastaların Yoğun Bakım ünitelerindeki takibinde Ekokardiografinin rutin olarak kullanılmasının hastanede kalış süresini, morbiditeyi ve mortaliteyi önemli ölçüde azaltabileceği kanaatindeyiz.
The Feasibility of a Cloud-Based Low-Cost Environmental Monitoring System Via Open Source Hardware in Greenhouses
Authors: ÇAYLI Ali , AKYÜZ Adil , BAYTORUN A. Nafi , ÜSTÜN Sait , MERCANLI Ali Selçuk 
Published: April 2018

One of
the most critical parameters in agricultural production is environmental
conditions. It is of vital importance to ensure and monitor suitable climatic
conditions for various controlled agricultural structures and production
systems such as greenhouses. To this aim, most data monitoring systems cannot
be efficiently used due to high cost and insufficient technical knowledge. It
is possible to design low-cost and scalable monitoring, control and data
acquisition systems via open source hardware in order to monitor climatic data
for agricultural practices in small enterprises and rural areas. In this study,
a low-cost system designed via open source hardware was tested under real
conditions. Temperature and relative humidity were measured via the sensors in
the system and sent to a data server through a wireless network. In addition,
collected data was compared to reference devices for statistical analysis. The
results suggest that these low-cost systems, which are designed via open source
hardware, can be used as a data collection and decision support system by
agricultural enterprises.
Sosyal Medyanın Üniversite Öğrencilerinin Satın Alma Davranışlarına Etkisi Üzerine Kavramsal Bir Bakış
Authors: YILDIRIM Seda , KALENDER Mert 
Published: April 2018

Sosyal
medya kullanımının gittikçe yaygınlaşması ve özellikle genç kitleler tarafından
daha çok tercih edilmesi, bu alanda yapılan çalışmaların önemini arttırmıştır.
Ülkemizde de sosyal medya gençler tarafından sıklıkla kullanılmakta olup,
işletmelerin ve markaların dikkatleri sosyal medya araçlarına yönelmiştir. Bu
noktada, çalışmanın amacı sosyal medyanın üniversite öğrencilerinin satın alma
davranışlarına etkisini kavramsal bir çerçevede incelemek ve araştırmaktır.
Amaç doğrultusunda, Türkiye’de yapılan son araştırmalardan, raporlardan ve
çeşitli akademik çalışmalardan yararlanılmış, bazı temel bulgular ve sonuçlara
elde edilerek, yorumlanmıştır. Bu
çalışmanın en önemli kısıtı, tarama modelinin kullanılması ve sadece Türk
literatüründen yararlanılmasıdır.
Evaluation of Placement and Protection Programs of Indonesian Migrant Worker
Authors: Wahab Abdul , Tunas Billy , Ludin Muchlis R. 
Published: April 2018

The purpose of this study is to evaluate the placement and protection programs of Indonesian migrant worker that they run by the Ministry of Manpower and The National Agency of Placement and Protection of Indonesian Migrant Worker. This research is done by observation, interview and documentation with Discrepancy Evaluation Model method. The method is to evaluate design, installation, process and the Implementation of the Placement and Protection programs of Indonesian migrant worker against the Employment Placement Private Company to provide Indonesian Migrant Workers services licensed by the Ministry of Manpower and placement permits from The National Agency for Placement and Protection of Indonesian Migran Workers, the role of local government on one-stop integrated service, the role of labor attaches in Indonesian embassy from the Ministry of Manpower and supervision of The Nasional Agency for Placement and Protection of Indonesian Migrant Worker. The conclusion of this study indicates that there is a gap in discrepancy at 16.01% from the target to be achieved.
Neurological findings in autosomal dominant polycystic kidney disease
Authors: YILDIZ Demet , YILDIZ Abdülmecit 
Published: April 2018

Objective: Autosomal dominant polycystic kidney disease (ADPKD)
mainly affects the kidneys, but other abnormalities like intracranial aneurysms
(ICAs) are not uncommon. In this study, we aimed to investigate retrospectively
frequency of ICA and other neurological abnormalities in ADPKD patients. Methods: One hundred and forty patients with ADPKD who did not receive replacement
therapy and followed-up at outpatient clinic were evaluated. Results: The mean age of the patients was 43.4 ± 13 years and mean glomerular filtration
rate was 87 ± 15 ml/min. ICA was detected in four (2.8%) patients. Three patients were from the same family. Thirteen (9.3%)
patients had magnetic resonance angiography due to their family stories, but
aneurysm was not seen in them. Conclusion: Individuals with ADPKD who
have a history of aneurysm or hemorrhage in their family should be screened for
aneurysm due to mortality and risk of recurrent rupture.
Local resection for placenta accreta spectrum: a conservative uterus sparing technique for anterior placenta accreta
Authors: UYSAL Gülsüm , TANRIDAN OKÇU Nefise , ESKİMEZ Eda , SAYGILI YILMAZ Esra 
Published: April 2018

Objective: To evaluate and describe a surgical approach for
uterine preservation and management of postpartum hemorrhage in placenta
accreta spectrum (PAS). Methods: We analyzed the data of
patients who were diagnosed with placenta previa companied with PAS prenatally
and subsequently performed cesarean section with local resection technique to
manage postpartum hemorrhage and uterine preservation at our tertiary care
center between January 2016 and August 2017. The technique includes the local
resection of placental invasion site and suturing the new uterine edges without
internal iliac artery ligation. Results: The diagnosis of placenta
accreta spectrum anterior in all 11 cases was confirmed intraoperatively. Only
1 case underwent hysterectomy in a second operation. Two of cases had bladder
injury. The mean operative time was 99 ± 30 minutes. The mean received packed red
blood cells was 2.3 ± 1.0 units. The mean length of postoperative hospital stay
was 4.5 ± 1.4 days. There was no late complications regarding coagulopathy and infection.
No maternal mortality was observed. Conclusion: Local resection is an
effective, safe and fertility preserving approach in selected patients with
PAS.
Jahe mengurangi jumlah koloni uropathogenic Escherichia coli pada wanita menopause dengan infeksi saluran kemih asimtomatis
Authors: Rosmana Dony , Hardianto Gatut , Debora MS Kartuti 
Published: April 2018

Objective: To prove the effect of ginger in the UropathogenicEscerichia coli Colonies in menopausal women.Materials and Methods: A pra-experimental study with onegroup pre test-post test design. Ginger with a similar variety andage is turned into a powder capsule. The subject of the research ispatient in the geriatric and menopause outpatient clinicDr.Soetomo Central Hospital-Surabaya. Each subject taken gingerpowder for five days in row. Midstream clean catch urine wasperformed before and after the treatment in order to identify andcount the colony of Uropathogenic Escerichia coli.Results: 12 out of 52 participants had a positive UropathogenicEscerichia coli result from the culture before treatment. 5 subjectshad colony count 105cfu/ml and 7 subjects <10cfu/ml. 11subject shows a negative result and 1 subject still had a positiveresult although a number of colony is decrease cfu/mlbecome 2x103cfu/ml Tujuan: Membuktikan pengaruh jahe terhadap jumlah koloniuropathogenic Escerichia coli pada kultur urin dari wanitamenopause dengan infeksi saluran kemih asimtomatis.Bahan dan Metode: Penelitian pra-eksperimental one grouppretest-posttest design. Jahe dengan jenis dan usia panen samadiolah menjadi kapsul serbuk jahe. Subyek penelitian diperoleh dipoli Geriatri dan Menopause RSUD.Dr.Soetomo Surabaya. Setiapsubyek diberikan kapsul serbuk jahe selam 5 hari. Dilakukankultur urin tampung porsi tengah untuk identifikasi dan hitungjumlah koloni sebelum dan sesudah perlakuan.Hasil: Dari 52 partisipan, didapatkan 12 subyek dengan hasilidentifikasi dan hitung koloni kultur sebelum perlakuan yangpositif uropathogenic Escerichia coli, 5 subyek dengan hitungkoloni ≥ 105cfu/ml dan 7 subyek <105cfu/ml. Didapatkan 11subyek dengan hasil hitung koloni kultur ulangan steril dan 1subyek dengan hasil hitung koloni kultur ulangan tetap positifdengan jumlah koloni menurun 4cfu/ml menjadi 2x10cfu/ml3
Penurunan progesterone-induced blocking factor (PIBF) sebagai penanda preeklampsia
Authors: Salman Achmad , Wicaksono Budi , Dachlan Erry Gumilar , Widjiati Widjiati 
Published: April 2018

Background: Pathogenesis of preeclampsia still a controversial research objects. Progesterone induced blocking factor has protective effects in pregnancy.Objectives: To compare PIBF serum level and placental weight and investigate correlation between both in preeclampsia.Methods: This experimental study used 16 Mus musculus with normal pregnancy and 16 Mus musculus that were injected with anti Qa-2 to create a preeclampsia model. Terminations of were performed in day 16th, followed by ELISA examination for PIBF serum level and placental weight measurement.Result: PIBF serum level significantly reduced on preeclampsia model compared with control (33,21±29,36 ng/ml vs 105,76±59,69 ng/ml; p<0,05). There was no different of placental weight in preeclampsia model compared with control (97,75±50,74 mg vs 116,09±44,45 mg; p>0,05). There was no significant correlation between PIBF serum level and placental weight.Conclusion: Decreased of PIBF serum level could be used as a marker of preeclampsia. Decreased of PIBF serum level may be correlate with placental pathology in preeclampsia.
Keikutsertaan Kelas Ibu Hamil Berpengaruh terhadap Pengetahuan dan Sikap Ibu dalam Praktik Inisiasi Menyusu Dini
Authors: Rahmawati Elsa Budi Sihsilya , Kuntoro R , Trijanto Bambang 
Published: April 2018

Strategi Pemerintah dalam menurunkan AKI dan AKB salah satunya kelas ibu hamil. Tujuan penelitian ini mengetahui pengaruh keikutsertaan ibu di kelas ibu hamil terhadap praktik IMD pada ibu bayi usia 6-8 bulan di wilayah kerja Puskesmas Sisir Kota Batu. Penelitian ini merupakan penelitian analitik dengan desain cohort retrospektif. Populasi terbagi menjadi dua, populasi terpapar yang mengikuti kelas ibu hamil saat hamil anak terakhir dan populasi tidak terpapar ibu yang tidak mengikuti kelas ibu hamil. Besar sampel 32 responden. Analisis data dengan uji chi square. Hasil analisis bivariat usia (p value = 0,229), pendidikan (p value = 0,1790, paritas (p value = 0,011), pengetahuan (p value = 0,047), sikap (p value = 0,893), riwayat persalinan (p value = 0,021), informasi (p value = 0,472), penolong persalinan (p value = 0,017), tempat persalinan (p value = 0,003), keikutsertaan kelas ibu hamil (p value = 0,27), pengambil keputusan (p value = 0,137), penyuluhan saat hamil (0,16) Hasil analisis menunjukkan variabel yang signifikan adalah paritas (p=0,011), pengetahuan (p=0,047), penolong persalinan (p=0,017), tempat persalinan (0,003), riwayat persalinan (p=0,021), penyuluhan saat hamil (p=0,010). Kesimpulan penelitian ini tidak ada pengaruh keikutsertaan ibu di kelas ibu hamil terhadap praktik IMD, akan tetapi kelas ibu hamil berpengaruh terhadap pengetahuan dan sikap ibu. Pengetahuan berpengaruh terhadap praktik IMD.
Three years survival rate of epithelial ovarian cancer patients in Dr. Kariadi Hospital, Semarang, Central Java
Authors: Damayanti Indah Nur , Yulianti Indra , Kusumastuti Etty Hary 
Published: April 2018

Objectives: to determine the association between prognostic factors of ovarian cancer with a 3-years survival rate of epithelial ovarian cancer patients.Material and Method: Retrospective cohort study was conducted in 90 patients (during 2012) at Dr.Kariadi General Hospital. Kaplan meier, Log rank and Cox regression were used to analyse survival rate and prognostic factors that influence the disease.Result: Overall 3-years survival rate of epithelial ovarian cancer patients were 58.5% (Kaplan meier). Three-years survival rates were 89.3%, 44,4%, and 35.1% for patients in stage I, stage II, and stage III, respectively, and no patient survive up to 3 years in stage IV. Prognostic factors that associated with 3-years survival rate were stage of the disease, ascites, residual tumor, and type of histopathology {p<0,001; p=0,001; p=0,004; p=0,041, respectively (Log rank test)}, whereas age and size of tumor were not associated. After using multivariate analysis (Cox regression) only stage of the disease was associated with 3-years survival rate of epithelial ovarian cancer patients.Conclusion: There were an association between stage of the disease, ascites, residual tumor, type of histopathology, and 3-years survival rate of epithelial ovarian cancer patients. Stage of the disease was a prognostic factor that most influence 3-years survival rate of epithelial ovarian cancer patiens in this study.