bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of Paracetamol exposure on hepatic and renal tissues during statin usage
Authors: Aksun Saliha , Gökcimen Alpaslan , Kahyaoglu Fadime , Demirci Buket 
Published: February 2019

Abstract

Objective
Statins and Paracetamol have widespread use in clinic and both drugs possess similar side effects; therefore, we investigated if drug-interaction occurs when the combination of these two drugs is used during therapy.

Materials and methods
A total of 32 (12–15 months old) grown-up male rats were divided into four groups: Control group, RSV group (10 mg/kg Rosuvastatin/daily), APAP group (50 mg/kg Paracetamol/5 days/weekly), RSV+APAP (10 mg/kg Rosuvastatin/daily+50 mg/kg Paracetamol/5 days/weekly). At the end of 8 weeks of chronic treatment, the blood and tissue samples were taken under the Ketamine and Xylasine anesthesia (50 mg/kg and 5 mg/kg, respectively).

Results
In the liver, sinusoidal dilatations, pyknotic nuclei and hemorrhagic foci are more frequently seen in the group receiving combination therapy; although serum liver functions among groups were not significantly different. Kidney histopathologic alterations in APAP and RSV+APAP groups were found more distinct than in RSV alone group. Inducible nitric oxide synthase activity was highly increased with combination therapy in liver and kidney tissues.

Conclusion
RSV-Paracetamol interaction may occur as an important drug interaction histopathologically even before it is manifested biochemically in the clinic.
An Accelerated Test Method to Evaluate Cementitious Mixtures Subjected to Chemical Sulfate Attack
Authors: Aguayo Federico M. , Drimalas Thano , Folliard Kevin J. 
Published: February 2019

Abstract
External sulfate attack continues to be a major threat to the long-term durability of concrete structures. Soil or water containing sufficient levels of sulfates can penetrate and chemically react with the hydrated cement compounds, leading to volumetric expansion, and in severe cases, softening of the hardened cementitious paste. While ASTM C1012, Standard Test Method for Length Change of Hydraulic-Cement Mortars Exposed to a Sulfate Solution, is the most widely accepted performance test method used to access the sulfate resistance of cementitious binders, the test requires at least six months and often up to twelve months to perform. This article presents a new accelerated method that places mortar bar specimens under high-vacuum while immersed in sulfate solution to accelerate the penetration and diffusion of sulfates in the specimens and therefore, the degradation and measured linear expansion of the specimens. Expansion, mass change, and visual degradation were assessed over time on mortar specimens immersed in a 5 % and 0.89 % sodium sulfate solution (Na2SO4) and subjected to the vacuum saturation procedure. Expansion results are compared with companion mortar bars that followed the ASTM C1012 method without vacuum saturation. When compared with the current ASTM method, the new test method showed a significant acceleration in the rate of expansion with severe visual deterioration observed two to three times quicker. Visual degradation and measured expansion occurred more rapidly for specimens subjected to the accelerated method and immersed in 5 % Na2SO4; however, mixtures subjected to the accelerated method and immersed in 0.89 % Na2SO4 still showed much faster expansion than companion specimens tested according to ASTM C1012 in 5 % Na2SO4.
Hepatoblastoma and Wilms’ tumour in an infant with Beckwith–Wiedemann syndrome and diazoxide resistant congenital hyperinsulinism
Authors: Uppal Saurabh , Blackburn James , Didi Mohammed , Shukla Rajeev , Hayden James , Senniappan Senthil 
Published: February 2019

Summary
Beckwith–Wiedemann syndrome (BWS) can be associated with embryonal tumours and congenital hyperinsulinism (CHI). We present an infant with BWS who developed congenital hepatoblastoma and Wilms’ tumour during infancy. The infant presented with recurrent hypoglycaemia requiring high intravenous glucose infusion and was biochemically confirmed to have CHI. He was resistant to diazoxide but responded well to octreotide and was switched to Lanreotide at 1 year of age. Genetic analysis for mutations of ABCC8 and KCNJ11 were negative. He had clinical features suggestive of BWS. Methylation-sensitive multiplex ligation-dependent probe amplification revealed hypomethylation at KCNQ1OT1:TSS-DMR and hypermethylation at H19
/IGF2:IG-DMR consistent with mosaic UPD(11p15). Hepatoblastoma was detected on day 4 of life, which was resistant to chemotherapy, requiring surgical resection. He developed Wilms’ tumour at 3 months of age, which also showed poor response to induction chemotherapy with vincristine and actinomycin D. Surgical resection of Wilms’ tumour was followed by post-operative chemotherapy intensified with cycles containing cyclophosphamide, doxorubicin, carboplatin and etoposide, in addition to receiving flank radiotherapy. We report, for the first time, an uncommon association of hepatoblastoma and Wilms’ tumour in BWS in early infancy. Early onset tumours may show resistance to chemotherapy. UPD(11p15) is likely associated with persistent CHI in BWS.

Learning points:

Long-acting somatostatin analogues are effective in managing persistent CHI in BWS.

UPD(11)pat genotype may be a pointer to persistent and severe CHI.

Hepatoblastoma and Wilms’ tumour may have an onset within early infancy and early tumour surveillance is essential.

Tumours associated with earlier onset may be resistant to recognised first-line chemotherapy.
Determining Which Prosthetic to Use During Aortic Valve Replacement in Patients Aged Younger than 70 Years: A Systematic Review of the Literature
Authors: Borger Philip , Charles Eric J , Smith Eric D , Mehaffey J Hunter , Hawkins Robert B , Kron Irving L , Ailawadi Gorav , Teman Nicholas 
Published: February 2019

Background: The choice of bioprosthesis versus mechanical prosthesis in patients aged less than 70 years undergoing aortic valve replacement (AVR) remains controversial, with guidelines disparate in their recommendations. The objective of this study was to explore outcomes after AVR for various age ranges based on type of prosthesis.
Methods: A systematic review was undertaken according to the Preferred Reporting Instructions for Systematic Reviews and Meta-Analyses (PRISMA) guidelines by using Medline (PubMed), Cochrane, Web of Science, Embase, and Scopus databases. Rates of long-term survival (primary outcome), reoperation, major bleeding, thromboembolism, stroke, structural valve deterioration, and endocarditis were compared between subjects receiving biologic and mechanical prostheses. Findings were grouped into patients aged <60 years, aged ≤65 years, and finally aged <70 years.
Results: A total of 19 studies met inclusion criteria. Seven evaluated patients aged <60 years, 4 of which found mechanical prosthesis patients to have higher long-term survival, whereas the remaining studies found no difference. Eight additional studies included patients aged 65 years or younger, and 9 studies included patients aged <70 years. The former found no difference in survival between prosthesis groups, whereas the latter favored mechanical prostheses in 3 studies. Bleeding, thromboembolism, and stroke were more prevalent in patients with a mechanical prosthesis, whereas reoperation was more common in those receiving a bioprosthesis.
Conclusions: Published literature does not preclude the use of bioprostheses for AVR in younger patients. As new valves are developed, the use of bioprosthetic aortic valves in younger patients will likely continue to expand. Clinical trials are needed to provide surgeons with more accurate guidelines.
Negative Pressure versus Conventional Sternal Wound Dressing in Coronary Surgery Using Bilateral Internal Mammary Artery Grafts
Authors: Ruggieri Vito Giovanni , Olivier Maud-Emmanuelle , Aludaat Chaudi , Rosato Stefano , Marticho Paul , Saade Yves Assad , Lefebvre Annick , Poncet Anne , Rubin Sylvain , Biancari Fausto 
Published: February 2019

Background: Sternal wound infection (SWI) is a major complication occurring often after coronary artery bypass grafting (CABG) using bilateral internal mammary artery (BIMA) grafts. The aim of this study is to assess whether such a risk may be reduced by using incision negative pressure wound therapy (INPWT).
Methods: Data on patients undergoing isolated CABG using BIMA grafts at the Reims University Hospital, France, from 2013 to 2016 without or with INPWT was prospectively collected.
Results: INPWT was used in 161 patients and conventional sterile wound dressing was used in 266 patients. Propensity score matching resulted in 128 pairs with similar characteristics. SWIs were similarly distributed between the conventional sterile wound dressing (10.9%) and the INPWT cohorts (10.2%) (P = 1.00). Patients treated with INPWT had a lower rate of deep SWI/mediastinitis than patients who had conventional sterile dressing (5.5% versus 10.2%, P = .210), but the difference did not reach statistical significance. Tests for interaction confirmed these findings in different patient subgroups.
Conclusion: The routine use of INPWT may not significantly reduce the risk of SWI in patients undergoing BIMA grafting. In view of previous reports showing a benefit with the use of this method, a large randomized study is justified to assess the efficacy of INPWT in patients undergoing cardiac surgery.
A New Perspective in Comparing Injuries Caused by Short-Duration External and Internal Forces in Saphenous Vein
Authors: Denli Yalvac Emine Seyma , Cumbul Alev , Uslu Unal , Soztutar Erdem , Bilisli Edibe , Balak Naci 
Published: February 2019

Background: Great saphenous vein (GSV) graft failure is one of the major reasons for repeat bypass grafting. A comparison of the effects of simultaneous, short-duration, externally squeezing and internally distending forces on the same segment of ex-vivo human GSV has not yet been published, although similar studies have compared the experimental injury of different ex-vivo human veins.
Methods: Approximately 8-cm-long segments of GSV were harvested from each of the 15 patients. For each specimen, one end of the vein piece was occluded at a distance of 1 cm with an external cross-clamp for 5 min and the other end was similarly occluded at a distance of 1 cm by an endoluminal balloon. The middle sections of the veins, which were not occluded by any means, were taken as the control group. Two histologists, who were blinded to the groups, graded the hematoxylin and eosin (H&E) and Weigert-Van Gieson (WVG) stained sections semi-quantitatively and performed the histomorphometric measurements.
Results: The result of the histopathological evaluation of the intima layer showed that the microscopic scoring of lesions in the balloon group was significantly higher than that in the clamp and control groups (5.16 ± 1.32, 3.83 ± 0.75, and 1.00 ± 1.09, respectively, P < .001). In the adventitia layer, this level of scoring increased more in the clamp group than in the balloon and control groups (5.16 ± 1.16, 3.00 ± 0.89, and 0.16 ± 0.40, respectively, P < .001).
Conclusion: Both the endoluminal balloon and external clamp techniques have harmful effects on the vein wall. Studying different kind of forces on different veins cannot provide us with reliable comparisons.
Ongoing Phase I Studies of Immune Checkpoint Inhibitors in China
Authors: Fang Wenfeng , Zhao Shen , Zhang Yaxiong , Ma Yuxiang , Zhao Hongyun , Zhang Li 
Published: February 2019

Abstract

Background
Cancer immunotherapy targeting immune checkpoint inhibitors (ICIs) has been shown to be a promising strategy in the treatment of various malignancies. Despite the proven efficacy and tolerability of ICIs based on 113 clinical trials globally, data regarding the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of ICIs in the Chinese population are lacking. As of June 1, 2018, not a single ICI has been approved by the China Food and Drug Administration.

Materials and Methods
Currently, there are 26 ongoing phase I studies actively investigating the safety, antitumor activity, and PK/PD profiles of six multinational corporation (MNC)-developed ICIs and eight domestic-developed ICIs in the Chinese population. Data regarding study designs, treatment interventions, targeted populations, and the current states of these studies were collected and summarized.

Results
We outlined 8 phase I studies assessing MNC-developed ICIs and 18 phase I studies assessing domestic-developed ICIs in the Chinese population in this article, in order to provide researchers with a clear picture of the status quo of ICI research and developments in China.

Conclusion
Immuno-oncology in China remains at a preliminary stage. Despite the substantial amount of phase I studies of ICIs, early-phase studies with designs incorporating characteristics of Chinese patients are still lacking.
SENIOR TOURISM PERSP ECTIVES IN THE CONTEXT OF THE PENSION REFORM IN RUSSIA
Authors: Ilkevich S. V. 
Published: February 2019

The pension reform in Russia, launched in 2018, will have pronounced and multifaceted impacts on many industries in terms of production, consumption, marketing and employment. The development of segments of senior people's tourism, the features and specificity of economic psychology, motivation and consumption of tourist products by people of the third age, the increasing inclusion of elderly workers in the labor force in the tourism and hospitality industry as a new productive resource and other strategic considerations are becoming even more relevant to scientific and practical examinations. The article presents an attempt to summarize the specific risks and problems that the tourism sector will have to face in connection with the increases in the retirement age. Along with this, the opportunities and prospects that are opened up to the industry as a whole and the development of particular types of tourism and tourism sub-sectors are identified and analyzed under the condition that the increases in the retirement age are indeed accompanied, as it is planned, by overall improvements in the socioeconomic activity, productivity and paying capacity of senior citizens. Accordingly, pensioners and pre-pensioners will provide greater demand in the market of tourist services. By attracting elderly people to work positions in the tourism and hospitality industry, the threats of mass unemployment and precariousization of employment of pre-retirees would be partially partly mitigated. The paper also presents examples of international experiences and practices in the development of tourism of the older generation and its employment in tourism, which will become more relevant along with the implementation of the pension reform taking into account socio-economic and cultural specifics, formal and informal institutions of the Russian society in general and the regions in particular.
Densitometric density of urinary stones as a predictive factor demonstrating their efficiency of disintegration in treatment of urolithiasis
Authors: Shevyrin Aleksej A. , Strelnikov Aleksandr I. 
Published: February 2019

Urolithiasis is one of the most common urological diseases, occurring in at least 3% of the human population and 34.2% of the Russian population. Data from the Ministry of Health of the Russian Federation show that in the past 4 years, the incidence of urolithiasis has increased from 405.2 to 460.3 patients per 100,000 population. The purpose of this study was to assess the significance of determining the density of urinary stones via computed tomography, as well as the chemical composition of urinary stones, in order to choose an optimal treatment strategy for patients with urolithiasis. The results of treatment of 108 patients with stones of different localization and sizes were investigated. The patients were subjected to laboratory examination to determine the urinary salt environment; moreover, the levels of electrolytes were examined in blood samples from the patients, and computed tomography densitometry was performed to determine the density of the detected stones. The qualitative chemical compositions of urinary stones in patients with urolithiasis were determined. The density of urinary stones was evaluated by computed tomography densitometry in these patients. The relationship was determined between the chemical compositions of stones and their corresponding densitometric densities. The densitometric density of urinary stones, as determined by computed tomography, can serve as a predictor of the effectiveness of stone disintegration, because it allows selection of the best method to destroy stones for treatment of urolithiasis.
ALAT KONTROL AKSES PINTU RUMAH DENGAN TEKNOLOGI SIDIK JARI DI LINGKUNGAN RUMAH PINTAR DENGAN DATA YANG DI ENKRIPSI
Authors: Siswanto Apri , Efendi Akmar , Yulianti Ana 
Published: February 2019

<p>Penggunaan konsep rumah cerdas dalam bidang sekuriti meningkat cukup signifikan akhir-akhir ini. Salah satu bidang yang menjadi perhatian adalah penggunaan teknologi biometric sidik jari untuk system otentikasi, misalnya otentikasi untuk masuk kedalam rumah. Paper ini bertujuan untuk menjelaskan sebuat prototype baru untuk otomasi dan keamanan pintu rumah yang mengkombinasikan teknologi biometric sidik jari dan arduino. Diharapkan sistem ini membantu meningkatkan keamanan dan kenyaman para penghuni rumah dengan instalasi yang mudah dan biaya yang murah. Sistem ini secara otomatis mengontrol (buka atau tutup) pintu berdasarkan sidik jari pengguna yang telah didaftarkan dalam basis data di mikrokontroler Arduino. Sistem utamanya terdiri dari mikrokontroler arduino, sensor sidik jari dan doorlock system. </p>
ANALISIS KINERJA PEGAWAI PUSBINDIKLAT PENELITI LIPI BERDASARKAN POLA PEMANFAATAN INTERNET MELALUI PENDEKATAN WEB USAGE MINING
Authors: Sukoco Sutrisno Heru , Sitanggang Imas Sukaesih , Sukoco Heru 
Published: February 2019

<em><span>Pengukuran kinerja pegawai dalam penggunaan layanan internet dapat dilakukan sebagai bagian dari penilaian kinerja. Pendekatan web usage mining melalui pengamatan rekam jejak akses internet yang tersimpan pada proxy server merupakan salah satu cara yang dapat diterapkan untuk memahami perilaku pengguna. Penelitian ini bertujuan untuk mendapatkan gambaran perilaku pegawai Pusbindiklat Peneliti LIPI dalam memanfaatkan layanan internet, mengukur level produktivitas pegawai berdasarkan lama waktu akses terhadap situs yang tidak mendukung pekerjaan dan memetakan kategori situs yang diakses apakah medukung tugas fungsi jabatannya. Penerapan algoritme </span></em><span>clustering<em> K-Means digunakan untuk memudahkan memahami pola akses pengguna. Data yang digunakan adalah log proxy server dan nilai prilaku pegawai Pusbindiklat Peneliti LIPI periode Agustus-Desember 2016. Hasil penelitian menunjukkan pola pemanfaatan internet oleh pegawai Pusbindiklat Peneliti LIPI belum sepenuhnya mendukung tugas fungsi jabatannya. Sekitar 83% pegawai menggunakan internet untuk mengakses situs yang tidak mendukung pekerjaan berada pada level rendah (0-4 jam per minggu). Berdasarkan hasil tersebut dapat disimpulkan bahwa prilaku penggunaan internet yang dilakukan pegawai Pusbindiklat Peneliti LIPI tidak mempengaruhi produktivitas secara signifikan.</em></span><div><span><em><br /></em></span></div><div><p class="JGI-KeteranganPenulis" align="center"><strong><em>Abstract</em></strong><em></em></p><p class="JGI-AbstractIsi">Measurement of employee performance in the use of internet services can be conducted as part of employee’s performance target. Web usage mining approach through observation of internet access records stored in the proxy server can be applied in understanding user behavior. This study aims to obtain an overview of employee behavior in utilizing internet services in Pusbindiklat Peneliti LIPI, measure the level of employee productivity based on the length of time access to sites that do not support the work and map the category of sites accessed to the task dutyof employee. K-Means clustering algorithm is used to group user access patterns. The data used are proxy server logs and employee’s performance target in Pusbindiklat Peneliti LIPI in period of August-December 2016. The results shows that the pattern of Internet use by employees Pusbindiklat Peneliti LIPI do not fully support the job function. About 83% of employees use the internet to access sites do not support jobs at low level access (ranging from 0-4 hours per week). Based on these results, it can be concluded that the behavior of internet use by employees of Pusbindiklat Peneliti LIPI does not affect their productivity significantly.</p><p class="JGI-AbstractIsi"> </p><span><em><strong>Keywords</strong>: clustering, K-Means, log proxy server, performance of employees, web usage mining<br /></em></span></div>
THE RELATIONSHIP BETWEEN PROFESSIONAL AND UNIVERSAL ETHICS OF ENGINEERS
Authors: Mat Zawiah , Sulaiman Nooraini , Arif Sazelin , Sidek Safiah , Ismail Norain , Arni Basir Siti 
Published: February 2019

Purpose: The aim of this study is to identify the relationship between professional and universal ethics of engineers.
Methodology:This study used quantitative methods to distribute the questionnaire by using random sampling to get data from 248 respondents of engineers from government and private sectors in Melaka. Respondents were required to valuate agreement to statement about work ethics that used a five-point Likert scale. Meanwhile, the scales used for measuring correlation were given as 0.000-0.2000 “negligible”, 0.201-0.400 “low”, 0.401-0.600, “moderate”, 0.601-0.800 “high”, and 0.801-1.000 “very high”. The Pearson correlation analysis was used to obtain these correlation results. In this research, we analysed the data collected using SPSS Ver.22 to identify the relationship between professional and universal ethics of engineers in Melaka.
Main Findings:The findings showed that all variables of professional of engineers correlated significantly with universal ethics. The significant level (p-value) was found to be less than 0.05, the study findings indicate a significant relationship between independent variables and dependent variable. Results obtained in this study confirmed that there were significant positive relationships between all variables that could influence professional and universal ethics.
Implications:This study contributes towards the improvement of Board of Engineers Malaysia (BEM’S) existing policy. Based on the study’s findings, the policy implication of this study includes: responsible bodies such as the governing institutions of engineers need to ensure that ethical practices are made as the main core in their profession by increasing knowledge and awareness about ethical practices in the engineering profession.
Originality:This study only focus on the relationship between professional and universal ethics of engineers and the results will be useful towards the improvement of Board of Engineers Malaysia (BEM’S) existing policy.
Fracture of the Sesamoid Bone of the Thumb
Authors: van der Naald Mira , van der Naald Niels , van der Velde Detlef , Schuurman Arnold H. 
Published: February 2019

Case:
Fracture of a sesamoid bone of the thumb is rare. We report a case of such a fracture after hyperextension of the thumb in a 26-year-old woman. After a volar plate injury was excluded, she was treated nonoperatively with 5 weeks of immobilization followed by physical therapy.

Conclusion:
After reviewing the current literature describing sesamoid fractures of the thumb, we recommend that fracture of the sesamoid of the metacarpophalangeal (MCP) joint should be regarded as an avulsion fracture. The role of surgical intervention should be limited to patients with a painful nonunion.