bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and synthesis of anticancer 1-hydroxynaphthalene-2-carboxanilides with a p53 independent mechanism of action
Authors: Spaczyńska Ewelina , Mrozek-Wilczkiewicz Anna , Malarz Katarzyna , Kos Jiri , Gonec Tomas , Oravec Michal , Gawecki Robert , Bak Andrzej , Dohanosova Jana , Kapustikova Iva , Liptaj Tibor , Jampilek Josef , Musiol Robert 
Published: April 2019

AbstractA series of 116 small-molecule 1-hydroxynaphthalene-2-carboxanilides was designed based on the fragment-based approach and was synthesized according to the microwave-assisted protocol. The biological activity of all of the compounds was tested on human colon carcinoma cell lines including a deleted TP53 tumor suppressor gene. The mechanism of activity was studied according to the p53 status in the cell. Several compounds revealed a good to excellent activity that was similar to or better than the standard anticancer drugs. Some of these appeared to be more active against the p53 null cells than their wild-type counterparts. Intercalating the properties of these compounds could be responsible for their mechanism of action.
Impact and mitigation of angular uncertainties in Bragg coherent x-ray diffraction imaging
Authors: Calvo-Almazán I. , Allain M. , Maddali S. , Chamard V. , Hruszkewycz S. O. 
Published: April 2019

AbstractBragg coherent diffraction imaging (BCDI) is a powerful technique to explore the local strain state and morphology of microscale crystals. The method can potentially reach nanometer-scale spatial resolution thanks to the advances in synchrotron design that dramatically increase coherent flux. However, there are experimental bottlenecks that may limit the image reconstruction quality from future high signal-to-noise ratio measurements. In this work we show that angular uncertainty of the sample orientation with respect to a fixed incoming beam is one example of such a factor, and we present a method to mitigate the resulting artifacts. On the basis of an alternative formulation of the forward problem, we design a phase retrieval algorithm which enables the simultaneous reconstruction of the object and determination of the exact angular position corresponding to each diffraction pattern in the data set. We have tested the algorithm performance on simulated data for different degrees of angular uncertainty and signal-to-noise ratio.
Status of Hypertension in Tehran: Potential impact of the ACC/AHA 2017 and JNC7 Guidelines, 2012–2015
Authors: Asgari Samaneh , Khaloo Pegah , Khalili Davood , Azizi Fereidoun , Hadaegh Farzad 
Published: April 2019

AbstractThis study aimed to determine the prevalence of hypertension, the recommended anti-hypertensive therapy and the percentage of hypertensive patients who had achieved the blood pressure (BP) target according to 2017 American College of Cardiology/American Heart Association (ACC/AHA) versus JNC7 and 8 guidelines, among Iranian population. Data of participants aged ≥20 years from the fifth phase (2012–2015) of the Tehran lipid and glucose study (N = 10,576) were analyzed, using survey analysis. The weighted prevalence of hypertension among those not on anti-hypertensive medications was 42.7 and 12.6%, applying the ACC/AHA and JNC7 guideline definitions, respectively; the corresponding values with including BP-lowering medication in definition of hypertension were 47.1% and 20.4%, respectively. However, 90% of these hypertensive people were found to have a 10-year cardiovascular disease risk of <10%. Applying the ACC/AHA guideline, anti-hypertensive medication was recommended for 21.9% of Tehranians, compared to 19.3 and 12.2% according to the JNC7 and 8 guidelines, respectively. Among Tehranians taking anti-hypertensive medication, 20% achieved the BP goal according to the ACC/AHA guideline, compared to the 42.1 and 53.6%, using JNC7 and 8 guidelines, respectively. Despite the tremendous increase in the prevalence of hypertension, most of the newly identified cases did not belong to the high-risk group.
Anterior-Only Approach for Posttraumatic Subaxial Cervical Spine Spondyloptosis: A Case Report and Review of Literature
Authors: Kumar Raj , Singh Suyash , Das Kuntal , Kumar Arushi 
Published: April 2019

AbstractSubaxial posttraumatic spondyloptosis is a rare entity with management dilemma in the literature. Various approaches have been discussed, but few reports focused on management plan and rationale. The authors reviewed the literature and reported a case of a 30-year-old woman presented with posttraumatic spastic quadriparesis. The patient had C6–7 spondyloptosis and was operated by anterior-only approach. There was improvement in both motor and sensory neurologic status. Surgical goals include vertebral realignment and stabilization. The authors conclude that anterior approach may be good enough if performed properly even if all three columns are involved.
Outcomes of the Adams–Berger Ligament Reconstruction for the Distal Radioulnar Joint Instability in 95 Consecutive Cases
Authors: Gillis Joshua A. , Soreide Endre , Khouri Joseph S. , Kadar Assaf , Berger Richard A. , Moran Steven L. 
Published: April 2019

Objective The objective of this article is to evaluate the outcomes and complication rate for Adams–Berger anatomic reconstruction of the distal radioulnar joint (DRUJ), in addition, to determine the role of sigmoid notch anatomy on failure.
Methods We conducted a retrospective chart review to evaluate adult patients that had undergone reconstruction of the DRUJ for instability with the Adams–Berger procedure between 1998 and 2015 within our institution with > 24 months follow-up. Charts were reviewed for patient demographics, mechanism of injury, outcome, and complications.
Results Ninety-five wrists in 93 patients were included. Mean age at surgery was 37.3 years with 65.2 months follow-up. At the last follow-up, 90.8% had a stable DRUJ, 5.3% did not, and 3.4% had some laxity. Postoperatively, 75.9% described either no pain or mild pain. Grip strength increased while pronosupination decreased. Procedure success was 86.3%, as 12 patients underwent revision at 13.3 months postoperatively. Reconstructive failure was more common in females when an interference screw was utilized for tendon fixation. Age, timing of surgery, type of graft, sigmoid notch anatomy, and previous surgery did not affect revision or failure rate.
Conclusion Our findings demonstrate that Adams–Berger reconstruction of the DRUJ provides reliable long-term results with an overall success of 86% at > 5 years follow-up.
Level of evidence/Type of study This is a Level IV, therapeutic study.
Low-Profile Neuroform Atlas Stent-Assisted Coiling of Intracranial Aneurysms: Single-Center Initial Experience
Authors: Pan Somnath , Kannath Santhosh Kumar , Rajan Jayadevan Enakshy 
Published: April 2019

Abstract
Background Neuroform Atlas stent is a relatively new device used for stent-assisted coiling (SAC) of wide-necked intracranial aneurysms.
Purpose To elaborate the initial experience in a single center to assess the efficacy and initial results of Neuroform Atlas for SAC of intracranial aneurysms.
Methods Between February 2017 and September 2018, eight patients (five females, three males; mean age 56 years) underwent SAC with Neuroform Atlas.
Results Five unruptured and three ruptured wide-necked aneurysms were treated with Neuroform Atlas SAC. Immediate complete occlusion modified Roy-Raymond class 1 (MRRC 1) or mild neck residue class 2 (MRRC 2) was achieved in three patients and five other patients had minimal residual interstitial filling of the aneurysm (MRRC 3b). One patient with ruptured intracranial aneurysm succumbed to the illness in the first postoperative day due to massive rebleed. Other seven patients remained clinically asymptomatic in the follow-up period. Patent stent was noted at three to seven months follow-up magnetic resonance angiography (MRA) in five patients. Complete occlusion of the aneurysm was noted in three patients, and minimal residual aneurysm was seen in two patients.
Conclusion Neuroform Atlas stent is safe and effective in achieving good angiographic outcome in complex intracranial aneurysms.
Factors Influencing Motor Outcome of Hippotherapy in Children with Cerebral Palsy
Authors: Seung Mi Yeo , Ji Young Lee , Hye Yeon Shin , Yun Sik Seo , Jeong Yi Kwon 
Published: April 2019

Objective This study was aimed to identify individual factors influencing the gross motor outcome of hippotherapy in children with cerebral palsy (CP).
Methods One hundred and forty-six children with CP (mean age: 5.78 ± 1.72 years, male: 56.2%) presenting variable function (gross motor function classification system [GMFCS], levels I–IV) participated in this study. Participants received 30 minutes of hippotherapy twice a week for 8 weeks. Clinical information including GMFCS level, age, sex, CP distribution, CP type, gross motor function measure-88 (GMFM-88), GMFM-66, and pediatric balance scale (PBS) score were collected retrospectively. We regarded the children with GMFM-66 score increased by 2.0 points as good responders to hippotherapy. Further we analyzed factors affecting good responders.
Results GMFCS level I and II compared with IV (odds ratio [OR] = 6.83) and III compared with IV (OR = 4.45) were significantly associated with a good response to hippotherapy. Higher baseline GMFM E (OR = 1.05) and lower baseline GMFM B (OR = 0.93) were also significantly associated with a good response to hippotherapy. Sex, age, CP type, and distribution were not factors influencing gross motor outcome of hippotherapy.
Conclusions The children with CP, GMFCS level I–III, with relatively poor postural control in sitting might have a greater chance to improve their GMFM-66 scores through hippotherapy. This supports the hypothesis that hippotherapy is a context-focused therapy to improve postural control in sitting.
Helmet Use among Two Wheeler Female Riders
Authors: Khan Rizwan , Krishnan Nadia , Dhandapani Manju , Dhandapani Sivashanmugam 
Published: April 2019

Abstract
Introduction The frequency of traffic collisions in India is among the highest in the world with more than 135,000 traffic collision-related deaths occurring every year. The “Global Status Report on Road Safety” listed by the World Health Organization identified the major causes of injury as driving over the speed limit, driving under the influence, and not using helmets and seat belts. Women face unique challenges after traumatic brain injury, due to differential laws and their enforcement.
Objectives To assess the use of helmet among female hospital workers (nurses, hospital attendants, sanitary attendants, and security guards) and their attitude toward helmet wearing.
Methods Purposive sampling was done among female two-wheeler-riding hospital workers. A questionnaire was developed to study the use of helmet and an attitude Likert scale for assessing attitude toward wearing helmet. Data were collected, coded, and analyzed using SPSS software version 21.
Results Of the total 89 women enrolled, 46.4% were mostly pillion riders, and 33% were mostly drivers. Only 19% were using helmet consistently, despite 93% owning it. Eighty-eight percent of the regular users were younger than 25 years, while 80% of the non-users were above 25 years. Even among regular drivers, 40% never wore helmet. Eighty-two percent of the non-users were merely casual despite knowing about its advantages.
Conclusion Helmet use is very poor among women (both drivers and pillion riders), despite working in hospital environment and owning helmet. Stricter enforcement of helmet law is needed, as education and knowledge per-se may not instil helmet use.
A CRACker of an adaptor connects dynein-mediated transport to calcium signaling
Authors: Sharma Mahak , Dwivedi Devashish 
Published: April 2019

Many different adaptor proteins activate the processivity of dynein–dynactin complexes and determine the specific cargo for retrograde transport by binding cargo receptors such as Rab GTP-binding (G) proteins. In this issue, Wang et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806097) identify two GTPases that can function directly as dynein adaptors during endocytosis and are regulated by calcium.
Anger Inhibition and Pain Modulation
Authors: Toledo Tyler A , Hellman Natalie , Lannon Edward W , Sturycz Cassandra A , Kuhn Bethany L , Payne Michael F , Palit Shreela , Güereca Yvette M , Shadlow Joanna O , Rhudy Jamie L 
Published: April 2019

AbstractBackgroundThe tendency to inhibit anger (anger-in) is associated with increased pain. This relationship may be explained by the negative affectivity hypothesis (anger-in increases negative affect that increases pain). Alternatively, it may be explained by the cognitive resource hypothesis (inhibiting anger limits attentional resources for pain modulation).MethodsA well-validated picture-viewing paradigm was used in 98 healthy, pain-free individuals who were low or high on anger-in to study the effects of anger-in on emotional modulation of pain and attentional modulation of pain. Painful electrocutaneous stimulations were delivered during and in between pictures to evoke pain and the nociceptive flexion reflex (NFR; a physiological correlate of spinal nociception). Subjective and physiological measures of valence (ratings, facial/corrugator electromyogram) and arousal (ratings, skin conductance) were used to assess reactivity to pictures and emotional inhibition in the high anger-in group.ResultsThe high anger-in group reported less unpleasantness, showed less facial displays of negative affect in response to unpleasant pictures, and reported greater arousal to the pleasant pictures. Despite this, both groups experienced similar emotional modulation of pain/NFR. By contrast, the high anger-in group did not show attentional modulation of pain.ConclusionsThese findings support the cognitive resource hypothesis and suggest that overuse of emotional inhibition in high anger-in individuals could contribute to cognitive resource deficits that in turn contribute to pain risk. Moreover, anger-in likely influenced pain processing predominantly via supraspinal (e.g., cortico-cortical) mechanisms because only pain, but not NFR, was associated with anger-in.
Asynchronous leaf and cambial phenology in a tree species of the Congo Basin requires space–time conversion of wood traits
Authors: De Mil Tom , Hubau Wannes , Angoboy Ilondea Bhély , Rocha Vargas Mirvia Angela , Boeckx Pascal , Steppe Kathy , Van Acker Joris , Beeckman Hans , Van den Bulcke Jan 
Published: April 2019

AbstractBackground and AimsWood traits are increasingly being used to document tree performance. In the Congo Basin, however, weaker seasonality causes asynchrony of wood traits between trees. Here, we monitor growth and phenology data to date the formation of traits.MethodsFor two seasons, leaf and cambial phenology were monitored on four Terminalia superba trees (Mayombe) using cameras, cambial pinning and dendrometers. Subsequently, vessel lumen and parenchyma fractions as well as high-resolution isotopes (δ13C/δ18O) were quantified on the formed rings. All traits were dated and related to weather data.Key ResultsWe observed between-tree differences in green-up of 45 d, with trees flushing before and after the rainy season. The lag between green-up and onset of xylem formation was 59 ± 21 d. The xylem growing season lasted 159 ± 17 d with between-tree differences of up to 53 d. Synchronized vessel, parenchyma and δ13C profiles were related to each other. Only parenchyma fraction and δ13C were correlated to weather variables, whereas the δ18O pattern showed no trend.ConclusionsAsynchrony of leaf and cambial phenology complicates correct interpretation of environmental information recorded in wood. An integrated approach including high-resolution measurements of growth, stable isotopes and anatomical features allows exact dating of the formation of traits. This methodology offers a means to explore the asynchrony of growth in a rainforest and contribute to understanding this aspect of forest resilience.
Evolutionary relationships among life-history traits in Caninae (Mammalia: Carnivora)
Authors: Porto Lucas Marafina Vieira , Maestri Renan , Duarte Leandro Da Silva 
Published: April 2019

AbstractOver the last few years, a debate about the relative roles of distinct factors on the evolution of lineages has gained prominence. The family Canidae is an excellent group for exploring this idea, owing to its rich fossil history. One of the most intriguing traits in canids is social organization, which varies from highly social to solitary species. However, we do not have a complete understanding of how sociality evolved in this clade. Here, we use a combination of phylogenetic analyses, ancestral character reconstructions and comparative methods on the only extant subfamily, Caninae, to understand how traits expressing ecological features evolved over the last 12.6 Myr. Our findings suggest that the evolution of low, medium and high sociality forms was abrupt and highly correlated with the evolution of hypo-, meso- and hypercarnivorous forms, respectively. In addition, our results suggest that the evolution of phenotypic traits in Caninae occurred through a sequential cause–effect relationship, where changes in habitat use and body size probably triggered changes in social behaviour, which in turn drove the evolution of diet.
Activator of G protein signaling 3 modulates prostate tumor development and progression
Authors: Adekoya Timothy O , Smith Nikia , Aladeniyi Temilade , Blumer Joe B , Chen Xiaoxin L , Richardson Ricardo M 
Published: April 2019

AbstractProstate cancer (PCa) is a leading cause of cancer death among men, with greater prevalence of the disease among the African American population in the USA. Activator of G-protein signaling 3 (AGS3/G-protein signaling modulator 1) was shown to be overexpressed in prostate adenocarcinoma relative to the prostate gland. In this study, we investigated the correlation between AGS3 overexpression and PCa malignancy. Immunoblotting analysis and real-time quantitative-PCR showed increase in AGS3 expression in the metastatic cell lines LNCaP (~3-fold), MDA PCa 2b (~2-fold), DU 145 (~2-fold) and TRAMP-C1 (~20-fold) but not in PC3 (~1-fold), relative to control RWPE-1. Overexpression of AGS3 in PC3, LNCaP and MDA PCa 2b enhanced tumor growth. AGS3 contains seven tetratricopeptide repeats (TPR) and four G-protein regulatory (GPR) motifs. Overexpression of the TPR or the GPR motifs in PC3 cells had no effect in tumor growth. Depletion of AGS3 in the TRAMP-C1 cells (TRAMP-C1-AGS3-/-) decreased cell proliferation and delayed wound healing and tumor growth in both C57BL/6 (~3-fold) and nude mice xenografts, relative to control TRAMP-C1 cells. TRAMP-C1-AGS3-/- tumors also exhibited a marked increase (~5-fold) in both extracellular signal-regulated kinase (ERK) 1/2 and P38 mitogen-activated protein kinase (MAPK) activation, which correlated with a significant increase (~3-fold) in androgen receptor (AR) expression, relative to TRAMP-C1 xenografts. Interestingly, overexpression of AGS3 in TRAMP-C1-AGS3-/- cells inhibited ERK activation and AR overexpression as compared with control TRAMP-C1 cells. Taken together, the data indicate that the effect of AGS3 in prostate cancer development and progression is probably mediated via a MAPK/AR-dependent pathway.
Adalimumab or Infliximab for the Prevention of Early Postoperative Recurrence of Crohn Disease: Results From the ENEIDA Registry
Authors: Cañete Fiorella , Mañosa Míriam , Casanova María José , González-Sueyro Ramiro C , Barrio Jesús , Bermejo Fernando , Nos Pilar , Iglesias-Flores Eva , García-Planella Esther , Pérez-Calle José Lázaro , Vicente Raquel , Vera Maribel , Ramos Laura , Rivero Montserrat , De Francisco Ruth , Montserrat Antonia , Benítez Olga , Navarro Pablo , Taxonera Carlos , Hinojosa Esther , Márquez-Mosquera Lucía , Navarro-Llavat Mercé , Ramírez-de la Piscina Patricia , Gomollón Fernando , Rodríguez-Alonso Lorena , Núñez-Alonso Alejandro , Fernández-Salazar Luis , Almela Pedro , Ríos León Raquel , De Castro Luisa , Gisbert Javier P , Ricart Elena , Cabré Eduard , Domènech Eugeni ,   ENEIDA registry by GETECCU
Published: April 2019

Abstract

Background
Anti–tumor necrosis factor agents (anti-TNFs) are efficacious at preventing the postoperative recurrence (POR) of Crohn disease, as demonstrated in 2 randomized controlled trials. However, real-life data for infliximab or adalimumab in this setting are scarce. Our aim was to assess both the efficiency of anti-TNFs at preventing early POR of Crohn disease in clinical practice and the associated risk factors for POR.

Methods
Patients in whom anti-TNFs were prescribed for the prevention of POR within 3 months after ileocolonic resection and who had an endoscopic assessment within 18 months were identified from the ENEIDA registry. Clinical and endoscopic features were collected within 18 months after surgery.

Results
In total, 152 patients were included (55 treated with infliximab, 97 with adalimumab, and 39% with concomitant immunosuppressants). Anti-TNF treatment was started after a median time of 29 days (IQR 13–44) after surgery. Eighty-two percent of patients had at least one risk factor for POR, and 82% had been exposed to anti-TNFs before the index surgery. Overall, 34% had endoscopic POR (as defined using a Rutgeerts endoscopic score > i1); 14% had advanced endoscopic POR (>i2); and 20% had clinical POR, with no differences between infliximab and adalimumab. In the multivariate analysis, only perianal disease (odds ratio 2.73, 95% confidence interval [CI] 1.26–5.91) and rectal involvement (odds ratio 2.79, 95% CI 1.09–7.14) were independent predictors of endoscopic POR.

Conclusions
In clinical practice, anti-TNFs for the prevention of POR of Crohn disease are frequently used in patients experienced with anti-TNFs and with concomitant immunosuppressants. The efficacy of infliximab and adalimumab for POR prevention is similar and in accordance with the results obtained in randomized controlled trials.
Impact of Simulated Corn Earworm (Lepidoptera: Noctuidae) Kernel Feeding on Field Corn Yield
Authors: Olivi B M , Gore J , Musser F M , Catchot A L , Cook D R 
Published: April 2019

Abstract
Corn earworm, Helicoverpa zea (Boddie) Lepidoptera: Noctuidae, has not been considered an economic pest of field corn. Historical losses estimates ranged from 1.5 to 2.5%, and a large number of foliar insecticide applications would be needed to minimize infestations. In recent years, Bt, Bacillus thuringiensis (Berliner) field corn, Zea mays (L.) Poales: Poaceae, technologies that exhibit activity against corn earworm have been introduced. However, it is unclear how much damage to corn ears (number of damaged kernels) is required to reduce yield. In this study manual damage methods were utilized to inflict defined levels of kernel damage and to impose damage at levels greater than observed with natural corn earworm infestations. Bt corn hybrids expressing the Agrisure Viptera (Vip 3A) trait were used to minimize injury from natural infestations of corn earworm. Manual kernel damage was imposed at R3 stage to mimic corn earworm feeding while avoiding interference with pollination. These methods were used in experiments where treatments were applied to individual ears and hand-harvested and in experiments where treatments were applied to all primary ears in the plot and machine-harvested. Damage of ≥60 kernels per ear was required to significantly reduce yield regardless of harvest method. Kernel damage from natural corn earworm infestations reported in other studies was much lower than 60 kernels per ear. Timely planting is a key component of all integrated pest management programs. Field corn planted during the recommended planting window for optimum yield is unlikely to experience corn earworm damage great enough to reduce yield.