bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethical dilemmas experienced by spouses of a partner with brain tumour
Authors: Francis Sara R , Hall Elisabeth OC , Delmar Charlotte 
Published: July 2019

Background: Caring for a partner with primary malignant brain tumour can be a dramatic life-changing event. Primary malignant brain tumour is known to give poor life expectancy and severe neurological and cognitive symptoms, such as changed behaviour and personality, which demand greater caring responsibilities from spouses. Aim: The aim of the study is to explore ethical dilemmas spouses experience in the everyday care of a partner in treatment for primary malignant brain tumour. Research design, participants and research context: A phenomenological and hermeneutic qualitative descriptive design was adopted as a method for collecting and analysing data. Ten spouses were interviewed twice using an in-depth, semi-structured interview guide. The interviews took place at the spouses’ homes or at the hospital. Ethical consideration: Ethical matters were considered throughout the research process. Permission from The National Committee on Health Research Ethics and the Danish Data Protection Agency was obtained. Findings: The analysis showed that the spouses perceived daily ethical dilemmas in caring for a partner with primary malignant brain tumour. Their life as well as their partner’s life had changed considerably. The main theme that emerged therefore was ‘oscillating in a changing relationship’. This theme was further elaborated in three subthemes that in more detail demonstrated the dilemmas: ‘doing the right thing in unpredictable daily situations’; ‘torn between patience and guilt’; and ‘living in a time of uncertainty, hope and despair’. Conclusion: Caring for a partner with changed behaviour and personality due to primary malignant brain tumour may involve exhausting ethical caring dilemmas. Spouses’ married life may change to a semi-professional asymmetrical relationship, which is challenged by the oscillation between acting responsibly for their partners’ well-being and caring dilemmas with no answer for what the right thing to do is. Mixed feelings of right and wrong, patience and guilt, hope and despair seem to be spousal companions through their partners’ progressing illness.
What Is the Optimal Management of Patients With Prior Septic Arthritis of the Ankle Who Are Undergoing Total Ankle Arthroplasty (TAA)?
Authors: Winters Brian , Da Rin de Lorenzo Ferdinando , O’Neil Jake 
Published: July 2019

Recommendation: There is a paucity of data regarding total ankle arthroplasty (TAA) in patients with prior infection involving the ankle, whether it be septic arthritis, osteomyelitis, or infection of the surrounding soft tissues. We recommend that patients with prior infections in the affected ankle be worked up for infection, including a thorough history and physical examination, as well as ordering serologic tests and possible aspiration of the joint. During ankle arthroplasty in patients with prior infection, antibiotics should be added to the cement (if used), and the joint should be thoroughly cleansed. Intraoperative cultures of bone and soft tissue should also be obtained. Level of Evidence: Consensus. Delegate Vote: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)
What Is the Diagnostic “Algorithm” for Infected Total Ankle Arthroplasty (TAA)?
Authors: Heidari Nima , Oh Irvin , Malagelada Francesc 
Published: July 2019

Recommendation: Patients who present with clinical symptoms and signs of periprosthetic ankle infection (pain, erythema, warmth, sinus tract, abscess around the wound) and sinus tracts communicating with the ankle/subtalar joint are likely to have total ankle arthroplasty (TAA) infection. In the absence of a sinus tract, elevated inflammatory markers (erythrocyte sedimentation rate [ESR] and C-reactive protein [CRP]) should prompt ankle joint aspiration for cell count, differential, and culture. The joint aspiration is to be repeated. If the same organism is identified in at least 2 cultures of synovial fluid, the patient is diagnosed to have an infection. If the repeat aspiration is negative, further investigation is warranted. In patients not requiring operative intervention for other reasons, nuclear imaging should be considered for diagnosis. If an operation is indicated, histologic examination (>5 neutrophils/high-power field) or synovial fluid analysis is conducted to confirm infection. Level of Evidence: Limited. Delegate Vote: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)
What Is the Best Technique for Performing Aspiration of Patients With Total Ankle Arthroplasty (TAA)?
Authors: Shakked Rachel 
Published: July 2019

Recommendation: In the absence of evidence, we recommend that ankle joint aspiration to evaluate for periprosthetic joint infection (PJI) be performed under sterile conditions via the anteromedial approach. Ultrasound guidance may be used if available but is not necessary to obtain an acceptable synovial fluid sample. Level of Evidence: Consensus. Delegate Vote: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus)
What Is the Treatment “Algorithm” for an Infected Total Ankle Arthroplasty (TAA)?
Authors: Raikin Steven , Parekh Selene , McDonald Elizabeth 
Published: July 2019

Recommendation: The treatment of an infected total ankle arthroplasty (TAA) is largely dictated by the acuity of the infection. The following treatment algorithm modified for TAA is recommended.19 Level of Evidence: Limited. Delegate Vote: Agree: 100%, Disagree: 0%, Abstain: 0% (Unanimous, Strongest Consensus).
Gene expressions of de novo hepatic lipogenesis in feline hepatic lipidosis
Authors: Valtolina Chiara , Robben Joris H , van Wolferen Monique E , Kruitwagen Hedwig S , Corbee Ronald J , Favier Robert P , Penning Louis C 
Published: July 2019

Objectives The aim of this study was to evaluate if de novo hepatic lipid synthesis contributes to fatty acid overload in the liver of cats with feline hepatic lipidosis (FHL). Methods Lipogenic gene expression of peroxisome proliferator-activated receptor-alpha ( PPAR-α), peroxisome proliferator-activated receptor-gamma ( PPAR-γ), fatty acid synthase ( FASN) and sterol regulatory element-binding factor ( SREBF1) were evaluated using quantitative RT-PCR in liver tissue of six cats with FHL and compared with the liver tissue of eight healthy cats. Results In liver tissue, PPAR-α, PPAR-γ and FASN mRNA expression levels were not significantly different ( P >0.12, P >0.89 and P >0.5, respectively) in the FHL group compared with the control group. SREBF1 gene expression was downregulated around 10-fold in the FHL group vs the control group ( P = 0.039). Conclusions and relevance The downregulation of SREBF1 in the liver tissue of cats with FHL does not support the hypothesis that de novo lipogenesis in the liver is an important pathway of fatty acid accumulation in FHL.
Management of cervical spine epidural abscess: a systematic review
Authors: Turner Anastasia , Zhao Linlu , Gauthier Paul , Chen Suzan , Roffey Darren M. , Wai Eugene K. 
Published: July 2019

Background: Cervical spinal epidural abscess (CSEA) is a localized infection between the thecal sac and cervical spinal column which may result in neurological deficit and death if inadequately treated. Two treatment options exist: medical management and surgical intervention. Our objective was to analyze CSEA patient outcomes in order to determine the optimal method of treatment. Methods: An electronic literature search for relevant case series and retrospective reviews was conducted through June 2016. Data abstraction and study quality assessment were performed by two independent reviewers. A lack of available data led to a post hoc decision not to perform meta-analysis of the results; study findings were synthesized qualitatively. Results: 927 studies were identified, of which 11 were included. Four studies were ranked as good quality, and seven ranked as fair quality. In total, data from 173 patients were included. Mean age was 55 years; 61.3% were male. Intravenous drug use was the most common risk factor for CSEA development. Staphylococcus aureus was the most commonly cultured pathogen. 140 patients underwent initial surgery, an additional 18 patients were surgically treated upon failure of medical management, and 15 patients were treated with antibiotics alone. Conclusion: The rates of medical management failure described in our review were much higher than those reported in the literature for thoracolumbar spinal epidural abscess patients, suggesting that CSEA patients may be at a greater risk for poor outcomes following nonoperative treatment. Thus, early surgery appears most viable for optimizing CSEA patient outcomes. Further research is needed in order to corroborate these recommendations.
IgA levels at diagnosis predict for infections, time to treatment, and survival in chronic lymphocytic leukemia
Authors: Ishdorj Ganchimeg , Streu Erin , Lambert Pascal , Dhaliwal Harbhajan S. , Mahmud Salaheddin M. , Gibson Spencer B. , Banerji Versha , Marshall Aaron J. , Johnston James B. 
Published: July 2019

Abstract
To better understand the relationship between baseline immunoglobulin measurements and subsequent clinical outcomes in chronic lymphocytic leukemia (CLL), we performed a retrospective analysis on 660 patients with CLL (72%), monoclonal B-cell lymphocytosis (MBL) (13%), and small lymphocytic lymphoma (SLL) (14%), diagnosed between 2005 and 2014 at CancerCare Manitoba. Of 511 patients who had their first immunoglobulin level determined within 3 months of diagnosis, abnormal (either increased or decreased) immunoglobulin M (IgM), IgG, and IgA values were observed in 58% of patients with CLL, 27% of patients with MBL, and 20% of patients with SLL. Immunoglobulin deviances were similar for MBL and CLL Rai stage 0 and for SLL and Rai stages I and II; for CLL, IgG and IgA abnormalities occurred with increasing frequency with advancing Rai stage. In contrast, the frequency of IgM abnormalities was similar in all patient groups. IgA abnormalities significantly correlated with high β2-microglobulin (B2M) expression, whereas abnormal IgG and IgA levels were associated with the use of IGHV1-69, 3-21, and 3-49 subtypes. Increases in IgG or IgM were commonly associated with the presence of a CLL-type M-band, whereas oligoclonal bands were frequently observed with increased IgA levels. Although abnormal levels of IgG and IgA at diagnosis were independent predictors for future immunoglobulin replacement, only abnormal IgA levels were associated with shorter time to first treatment and overall survival. These findings indicate that both reduced and elevated levels of IgG and IgA at diagnosis are important and independent prognostic markers for infection in CLL, with IgA being more relevant as a marker of disease progression and survival.
Pelvic side wall recurrence in locally advanced cervical carcinoma treated with definitive chemoradiation—clinical impact of pelvic wall dose
Authors: Gangopadhyay Aparna , Saha Subrata 
Published: July 2019

Objective:
Pelvic side wall dose in locally advanced cervical carcinoma treated with definitive chemoradiation has been debated. The present study investigated relationship of disease recurrence with dose for the pelvic side wall. It also attempted to identify minimal dose that significantly reduced recurrence.

Methods:
Pelvic side wall recurrence at median 24 months was assessed clinically and radiologically across three groups of patients receiving variable pelvic wall doses using no parametrial boost, external beam or interstitial boost, or dose escalated combined external beam with interstitial boost.

Results:
At 24 months, recurrence occurred in 3/155 boost vs 40/130 no boost patients. (p &lt; 0.0001). Receiver operating characteristic curve analysis demonstrated cut-off pelvic wall dose to be 58.9 Gy (p &lt; 0.0001). Dose escalated combined boost showed no significant benefit compared to single modality parametrial boost (p = 0. 0.553).

Conclusion:
Mean pelvic wall dose of at least 58.9 Gy offers clinically significant benefit in pelvic wall control. Doses recommended by guidelines should be adhered to in the patients’ best interests.

Advances in knowledge:
This preliminary study determined a relationship between recurrence rates and dose to the pelvic side wall and also a cut-off dose that significantly improved pelvic wall control in locally advanced cervical cancer.
PENGGUNAAN TEKNIK PERMAINAN “PETI MENULIS” UNTUK MENINGKATKAN KEMAMPUAN MENULIS MUFRODAT DI KELAS VII C MTs. NEGERI DONOMULYO
Authors: Solihah Barokatus 
Published: July 2019

This research aims at improving the student's learning achievement in Arabic teaching and learning by implementing “Peti Menulis Game” to improve students’ writing of vocabulary The subjects of this research are the students of class VII C that consists of 24 students of Madrasah Tsanawiyah Negeri (MTsN) Donomulyo Nanggulan Kulon Progo in academic year of 2013/2014. The product of this research is to control “mufrodat”( vocabularies) for the students of class VII C The implementing of this game shows that there is the increased on students vocabularies. On the first cycle students’ activities are categorized enough on 55,05 %, the second cycle goes better on 70,72% and the third cycle is categorited good on 81,81%.
Diferensiasi Organizational Citizenship Behavior (OCB): Studi Empiris Faktor Demografis pada Dosen Jurusan Tarbiyah STAIN Gajah Putih
Authors: Fauzi Farid , Hariyanto Surbakti Andika 
Published: July 2019

Demographic is one of the essential factors that may trigger the formation of organizational citizenship behaviour (OCB). This study investigates the level of differentiation of lecturers’ OCB profile at State Islamic College Gajah Putih based on demographic factors. The response is taken from 79 people as research sample. The data was analysed using technical analysis of Non Parametric Statistical Analysis through the Mann Whitney Test and Kruskal Wallis to determine the level of significance of the difference based on independent samples. The results of this study showed that there is a significant differentiation of OCB from several demographic predictors such as gender, employment status, years of service with a significance value of 0.001, 0.008 and 0.034 respectively. While the factors of the degree of education, career position status, and marriage do not have a significant differensiation with the value of 0.147, 0.395 and 0.358 respectively. It can be concluded that there are several predictors of demographic factors that have different and significant levels of OCB, namely gender, employment status and years of service, while predictors of education level, career position status and marital status do not have significant differences.
Leadership Pesantren: Urgensi Pendidikan dalam Menyiapkan Pemimpin Bangsa Berkualitas dan Bermoral
Authors: Rodliyah Siti 
Published: July 2019

People views on the role of education in pesantren has shifted over years. Previously, people thought that pesantren education was the second class. However, the profile of pesantren alumni and their contribution in various aspects of leadership in societies has proven that pesantren education contribute to nation development. People believe that pesantren is not an alternative education institution, but the major education provider to graduate well qualified human resources with leadership skill, as well as mastering both emotional and spiritual intelligent (ESQ). Besides essential to improve human development index of a country, ESQ is a pivotal element for a leader. This is in line with the argument of this paper that pesantren education even in this globalized era is able to produce the prospective leaders rich with relevant skills and intellectuality as well as deep understanding of kitab kuning (yellow book) as the classical Islamic intellectual literature and tailor it with modern science and technology. In turn, pesantren is able to groom well qualified, dignified, and have strong morality of prospective leaders in the globalized era.
miRNA-199a-5p functions as a tumor suppressor in prolactinomas
Authors: Jichao Wang , Jing Guo , Fei Wang , Lei Cao , Qian Liu , Jie Feng , Hongyun Wang , Hua Gao , Yazhuo Zhang 
Published: July 2019

AbstractProlactinomas are the most frequently observed pituitary adenomas (PAs), and 5%–18% tumors were resistant to the dopamine agonists (DAs). MicroRNAs (miRNAs) dysfunction play a key role in tumorigenesis. Agilent miRNA and an expression chip were used for six prolactinomas and three normal pituitary specimens. Differentially expressed genes were confirmed by RT-qPCR. The level of DDR1 and SAT1 was determined with tissue micro-array (TMA) and western blot. A MMQ cell line was used for functional experiments. We have identified 5-miRNA and 12 target gene signatures of prolactinomas through gene ontology analysis. miRNA-199a-5p was selected for experiments that integrated the results from prolactinomas specimens and a rat prolactinoma model induced by 17-b-estradiol. Tumors with low miRNA-199a-5p had a significantly invasive behavior and a higher tumor volume (p<0.05). DDR1 and SAT1, target genes of miRNA-199a-5p, had higher H-scores in the invasive group than those of the non-invasive group through TMA. An overexpression of miRNA-119a-5p suppressed the PRL secretion and the cell viability through upregulated the apoptosis level in MMQ cells (p<0.01). Furthermore, we found the target genes expression of DDR1 and SAT1 were affected by miRNA-199a-5p regardless of mRNA levels or protein levels. This study provided evidence that downregulation of miRNA-199a-5p may contribute to prolactinoma tumorigenesis.
Evaluation of the hypoglycemic effect of seven wild folkloric edible plants from Palestine
Authors: Hawash Mohammed , Jaradat Nidal , Elaraj Josephean , Hamdan Aseel , Lebdeh Saja Abu , Halawa Tamara 
Published: July 2019

Abstract
Alfa-amylase inhibitors are used to reduce glucose absorption by suppressing carbohydrate digestion. The current study aimed to evaluate seven wild edible Palestinian plants’ hydrophilic and lipophilic fractions against porcine pancreatic α-amylase enzyme. The lipophilic fractions of Arum palaestinum, Malva sylvestris, Plantago major, Centaurea iberica, Cichorium endivia, Bituminaria bituminosa, Sisymbrium irio leaves were sequentially separated with a nonpolar solvent hexane, while the hydrophilic fractions of the studied plants were separated with polar solvents ethanol and water. The activity of α-amylase inhibition was carried out by using α-amylase porcine pancreatic enzyme and 3,5-dinitrosalicylic acid (DNSA) method as well as by using Acarbose as a positive control. Among the studied plant’s hydrophilic fractions, C. iberica and C. endivia have the highest porcine pancreatic α-amylase inhibitory effect with an IC50 value of 12.33 µg/mL and 9.96 µg/mL, respectively. In addition, among the studied plant’s lipophilic fractions, S. irio and A. palaestinum have the highest porcine pancreatic α-amylase inhibitory effect with an IC50 value of 7.72 µg/mL and 25.3 µg/mL, respectively. In fact, these revealed results were near the values of Acarbose. The hydrophilic fractions of M. sylvestris and the lipophilic fractions of P. major plants exhibit remarkable α-amylase inhibitory activity. Hence, these leaves have a potential for use as regular supplements also; further investigations are required to isolate pure pharmacological molecules and to design suitable pharmaceutical dosage forms with anti-diabetic activity.
Optimization method in material bodies cloaking with respect to static physical fields
Authors: Alekseev Gennady V. , Tereshko Dmitry A. 
Published: July 2019

Abstract
Inverse problems associated with designing cylindrical DC electrical cloaking shells are studied.
Using the optimization method, these inverse problems are reduced to corresponding control problems in which electrical conductivities play the role of passive controls.
Admissibility of the optimization method for solving inverse design problems is justified.
A numerical algorithm based on the particle swarm optimization is proposed, and the results of numerical experiments are discussed.
Optimization analysis shows that high cloaking efficiency of the shell can be achieved either using a highly anisotropic single-layer shell or using a multilayer shell with isotropic layers.
In the latter case, the resulting cloaking shell admits simple technological realization using natural materials.
Analytical evaluation of a new Microdisk™ technology-based multiplex HPV genotyping system – the QPLEX™ HPV genotyping kit
Authors: Lim Yong Kwan , Kweon Oh Joo , Choi Jee-Hye , Park Seungman , Jung Keumsim , Kim Jiyeong , Park Ae Ja 
Published: July 2019

Abstract

Background
Recently, the QPLEX™ human papillomavirus (HPV) genotyping kit (QuantaMatrix, Seoul, Korea), a Microdisk™ technology-based multiplex system, was developed to detect 32 HPV genotypes. We evaluated the analytical performance of this kit by conducting a comparison study, precision evaluation and interference testing.

Methods
A total of 1594 cervical swab specimens were used to compare the QPLEX™ HPV genotyping kit with other commercially available kits (GeneFinder HPV Liquid Bead MicroArray Genotype polymerase chain reaction [PCR] kit, Infopia, Seoul, Korea; PANArray™ HPV Genotyping Chip, PANAGENE, Daejeon, Korea). For the determination of precision, we evaluated four types of precision profiles: repeatability, lot-to-lot variability, operator-to-operator variability and site-to-site variability. In addition, interference tests were performed with various interferents.

Results
The results of the QPLEX™ HPV genotyping kit showed almost perfect agreement with the other commercially available HPV genotyping assays. The combined precision was acceptable. In addition, there was no tested interferent that affected the results of the QPLEX™ HPV genotyping kit.

Conclusions
The QPLEX™ HPV genotyping kit showed acceptable analytical performance in our study. This assay could be a suitable option for HPV genotyping in routine and follow-up tests.