bluuebunny/crossref_metadata_2025_split huggingface dataset:
Musculoskeletal care pathways for adults with hip and knee pain referred for specialist opinion: a systematic review
Authors: Button Kate , Morgan Fiona , Weightman Alison Lesley , Jones Stephen 
Published: September 2019

ObjectiveMusculoskeletal care pathways are variable and inconsistent. The aim of this systematic review was to evaluate the evidence for the clinical and/or cost effectiveness of current care pathways for adults with hip and/or knee pain referred for specialist opinion.DesignSystematic review.Data sourcesElectronic database searches were carried out in MEDLINE, MEDLINE In-Process, Cumulative Index of Nursing and Allied Health Literature, Embase, PEDro, PubMed, Web of Science, Cochrane Central and Health Management Information Consortium without language restriction from 1990 onwards. Websites were reviewed for grey literature.Eligibility criteriaAll study designs and documents that considered care pathways for adults with musculoskeletal hip and/or knee pain referred for specialist opinion were screened by two reviewers. Risk of bias was assessed using The Critical Appraisal Skills Programme checklist for randomised controlled trials and the Joanna Briggs Institute checklists.Data extraction and synthesisData extraction and quality assessment were performed by one reviewer and checked by a second. Findings are reported narratively.ResultsThe titles and abstracts of 1248 articles were screened and 140 full-text articles retrieved. 19 papers reporting 17 studies met the study inclusion criteria. Quality was low due to study design and methodological flaws. Most of the outcomes relate to organisational process at the ‘meso’ level of a whole systems approach.ConclusionIt can be concluded that the pathway is not linear, containing variations and activity loops. The available evidence suggests that, from the point of referral for specialist opinion, a model is required that integrates the skills of all the different healthcare professionals and streamlining is required to ensure that individuals are seen by the healthcare professional that best meets their needs. There is very limited evidence of patient experience informing knee and hip care pathways.PROSPERO registration numberCRD42016035510.
Association between nut intake and non-alcoholic fatty liver disease risk: a retrospective case-control study in a sample of Chinese Han adults
Authors: Chen Bing bing , Han Ying , Pan Xinting , Yan Jianhui , Liu Wenjuan , Li Yangfan , Lin Xu , Xu Shanghua , Peng Xian-E 
Published: September 2019

ObjectivesNut consumption has been associated with a lower risk of type 2 diabetes, metabolic syndrome and insulin resistance. However, its effect on the risk of non-alcoholic fatty liver disease (NAFLD) is unknown. Therefore, we investigated the relationship between nut consumption and NAFLD risk.Setting and participantsWe conducted a retrospective case-control study including 534 patients diagnosed with NAFLD and 534 controls matched by sex and age (±5 years) from the Affiliated Nanping First Hospital of Fujian Medical University in China.Main outcome measuresInformation on dietary intake was collected using a semiquantitative food frequency questionnaire and nut consumption was calculated. Nut consumption was categorised using quartiles based on the distribution of daily nut intake of the controls. Binary logistic regression models were used to estimate ORs and the 95% CIs for the association between nut consumption and NAFLD risk.ResultsAfter adjusting for potential confounding variables, nut consumption was not associated with NAFLD risk in the overall sample. When the fully adjusted model was stratified by sex, a significant inverse association was found between high nut consumption and NAFLD only among the men in the highest quartile (OR=0.43; 95% CI 0.26 to 0.71;Ptrend =0.01). The inverse association of nut consumption with NAFLD risk in men remained significant after controlling for other known or suspected risk factors for NAFLD.ConclusionsDiets with a higher intake of nuts may be associated with a decreased risk of NAFLD, particularly in men.
Overall and work-related well-being of teachers in socially disadvantaged schools: a population-based study of French teachers
Authors: Temam Sofia , Billaudeau Nathalie , Vercambre Marie-Noel 
Published: September 2019

ObjectivesAs a human service profession, teaching presents specific risk factors that could be intensified in socially disadvantaged schools and, ultimately, impact the service quality. The aim of the present study was to evaluate the association between school socioeconomic status and teachers’ well-being.DesignPopulation-based postal survey ‘Teachers’ Quality of Life’ (MGEN Foundation for Public Health/French Ministry of Education; 2013). To categorise the school socioeconomic status, we used the ‘Education Priority Area (EPA)’ administrative classification, which is chiefly based on the proportion of underprivileged students and is available for primary and lower secondary state schools.ParticipantsIn-service French teachers randomly selected from among the teaching staff administrative list of the French Ministry of Education after stratification by sex, age and type of school.Outcome measuresIndicators of well-being at work included a question on job satisfaction, job difficulty evolution and the Maslach Burnout Inventory. The short version of the WHO Quality of Life questionnaire was used to evaluate overall well-being. Among primary and lower secondary school teachers, we evaluated cross-sectional associations between school EPA status and indicators of well-being, using logistic or linear regressions stratified by school level and adjusted for sociodemographic and work-related characteristics.ResultsIn the adjusted models, there was no significant difference in work-related well-being between teachers in EPA and non-EPA schools, both in primary school (n=154 vs n=788) and in lower secondary school (n=113 vs n=452). Regarding overall well-being, the only significant differences were seen among primary school teachers, with teachers in EPA schools reporting a worse perception of physical health and living environment than teachers in non-EPA schools.ConclusionUsing a representative sample of French teachers, we did not observe substantial differences in work-related well-being between teachers in EPA and non-EPA schools.
Open carpal tunnel release and diabetes: a retrospective study using PROMs and national quality registries
Authors: Zimmerman Malin , Eeg-Olofsson Katarina , Svensson Ann-Marie , Åström Mikael , Arner Marianne , Dahlin Lars 
Published: September 2019

ObjectivesTo study patient-reported outcome after open carpal tunnel release (OCTR) for carpal tunnel syndrome (CTS) in patients with or without diabetes using national healthcare quality registries.DesignRetrospective cohort study.SettingData from the Swedish National Quality Registry for Hand Surgery (HAKIR;www.hakir.se) were linked to data from the Swedish National Diabetes Register (NDR;www.ndr.nu).ParticipantsWe identified 9049 patients (10 770 hands) operated for CTS during the inclusion period (2010–2016).Primary outcome measuresPatient-reported outcome measures were analysed before surgery and at 3 and 12 months postoperatively using the QuickDASH as well as the HAKIR questionnaire with eight questions on hand symptoms and disability.ResultsPatients with diabetes (n=1508; 14%) scored higher in the QuickDASH both preoperatively and postoperatively than patients without diabetes, but the total score change between preoperative and postoperative QuickDASH was equal between patients with and without diabetes. The results did not differ between patients with type 1 or type 2 diabetes. Patients with diabetic retinopathy scored higher in QuickDASH at 3 months postoperatively than patients with diabetes without retinopathy. In the regression analysis, diabetes was associated with more residual symptoms at 3 and 12 months postoperatively.ConclusionsPatients with diabetes experience more symptoms both before and after OCTR, but can expect the same relative improvement from surgery as patients without diabetes . Patients with retinopathy, as a proxy for neuropathy, may need longer time for symptoms to resolve after OCTR. Smoking, older age, higher HbA1c levels and receiving a diabetes diagnosis after surgery were associated with more residual symptoms following OCTR.
Effectiveness of strategies for nutritional therapy for patients with type 2 diabetes and/or hypertension in primary care: protocol of a systematic review of randomised controlled trials
Authors: Simões Corrêa Galendi Julia , Leite Renata Giacomini Occhiuto Ferreira , Mendes Adriana Lúcia , Nunes-Nogueira Vania dos Santos 
Published: September 2019

IntroductionDespite the increasing number of drugs available and various guidelines on the management of type 2 diabetes mellitus (T2DM) and hypertension, an expressive number of patients continue with these diseases uncontrolled. Nutrition therapy (NT) plays a fundamental role in the prevention and management of these comorbidities, as well as in the prevention of complications related to them. The objective of this review is to evaluate the effectiveness of NT strategies in the management of patients with T2DM and/or hypertension in primary care. The selected strategies did not substitute pharmaceutical treatment but instead focused on preventing a sedentary lifestyle and stimulating healthy nutrition.Methods and analysisWe will perform a systematic review according to Cochrane methodology of randomised controlled trials, wherein patients with T2DM and/or hypertension were allocated into one of the two groups: NT strategy, which may be of dietary quality or energy restriction, and conventional treatment. The primary outcomes will be glycaemic and blood pressure (BP) control, measured by final glycosylated hemoglobin (HbA1c) (%) and BP (mm Hg), respectively. Four general and adaptive search strategies have been created for the Embase, Medline, Latin American and Caribbean Health Sciences Literature (LILACS) and Cochrane Central Register of Controlled Trials (CENTRAL) electronic databases. Two reviewers will independently select eligible studies, assess the risk of bias and extract data from the included studies. Similar outcomes measured in at least two trials will be plotted in the meta-analysis using Review Manager V.5.3. The quality of evidence of the effect estimate of the intervention will be generated according to the Grading of Recommendations Assessment, Development, and Evaluation Working Group.Ethics and disseminationAs no primary data collection will be undertaken, formal ethical assessment is not required. We plan to present the results of this systematic review in a peer-reviewed scientific journal, conferences and the popular press.PROSPERO registration numberOur systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 20 December 2018 (Registration number CRD42018118117).
Rapid cycle testing drives improved communication and satisfaction using in-person survey
Authors: Kuehnel Nicholas Anders , Morrison Andrea K , Ferguson Catherine C 
Published: September 2019

BackgroundGood communication with families improves safety and drives patient/family satisfaction. Rapid cycle improvement for the communication is difficult in our emergency department as current mailed surveys provide little and delayed data. We had two aims in this quality improvement study: (1) to increase proportion of families responding ‘always’ when asked if they received consistent communication from nurses and providers from 52% to 80% and (2) increase families reporting their visit as excellent, reflecting higher family satisfaction.MethodsKey drivers of the consistent communication were determined using the model for improvement. Interventions focused on interprovider communication and parental knowledge of communication processes. Eight Plan-Do-Study-Act ramps were conducted focusing on each of the key drivers, with 1–10 cycles per ramp. A five-question in-person survey was conducted at the time of disposition by the research assistants. Process and outcome measures were tracked on the statistical process control charts.ResultsMean percentage of families who reported always receiving consistent communication increased from 52% to 70% over 12 months. Additionally, families reporting their visit as ‘excellent’ increased from 62.5% to 75%. Using in-person surveys,weekly responses increased from 3 to 22.ConclusionsIterative processes to improve interprovider communication and inform families about their care led to improvement in families’ perceived communication consistency. Improved communication can lead to higher family satisfaction, most affecting those previously feeling neutral about their visit. In-person surveys can inform the real-time improvement efforts.
Does pellet size affect the ability of beef heifers to consume a pelleted supplement in a simulated grazing model?
Authors: Kelln L. , Newkirk R.W. , Smillie J. , Lardner H.A. , Penner G.B. 
Published: September 2019

The objective was to evaluate pellet consumption and refusals as affected by pellet size. Six ruminally cannulated heifers were used in a replicated 3 × 3 Latin square. Heifers were individually housed and fed a diet of grass hay (57.5%), mineral and vitamin supplement (8.0%), and canola meal (11.9%) in a feed bunk, and their respective wheat- and wheat-middling-based treatment pellet (22.7%) on artificial turf. The artificial turf had a mean staple length of 5 cm and a blade density of 45 blades cm−2. The pellets were small (SM; 4 mm diameter), medium (MED; 11 mm diameter), or large (LG; 50 mm diameter) in size. Heifers fed LG had greater pellet intake than SM (2.24 vs. 2.06 kg; P = 0.035), with MED being intermediate (2.12 kg). Heifers fed LG tended to have less pellet waste than SM (P = 0.074). Heifers fed MED pellets had greater concentration of ruminal short-chain fatty acids than SM and LG (91.3 vs. 84.7 and 89.0 mmol L−1; P = 0.009). The results indicate that feeding a LG pellet may increase intake and reduce waste compared with SM, and that pellet size may also affect ruminal fermentation.
Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes
Authors: Indorato Rose-Laure , Talapatra Sandeep K. , Lin Fangzhu , Haider Shozeb , Mackay Simon P. , Kozielski Frank , Skoufias Dimitrios A. 
Published: September 2019

Abstract
Arry-520 is an advanced drug candidate from the Eg5 inhibitor class undergoing clinical evaluation in patients with relapsed or refractory multiple myeloma. Here, we show by structural analysis that Arry-520 binds stoichiometrically to the motor domain of Eg5 in the conventional allosteric loop L5 pocket in a complex that suggests the same structural mechanism as other Eg5 inhibitors. We have previously shown that acquired resistance through mutations in the allosteric-binding site located at loop L5 in the Eg5 structure appears to be independent of the inhibitors' scaffold, which suggests that Arry-520 will ultimately have the same fate. When Arry-520 was assessed in two cell lines selected for the expression of either Eg5(D130A) or Eg5(L214A) STLC-resistant alleles, mutations previously shown to convey resistance to this class of inhibitors, it was inactive in both. Surprisingly, when the cells were challenged with ispinesib, another Eg5 inhibitor, the Eg5(D130A) cells were resistant, but those expressing Eg5(L214A) were strikingly sensitive. Molecular dynamics simulations suggest that subtle differences in ligand binding and flexibility in both compound and protein may alter allosteric transmission from the loop L5 site that do not necessarily result in reduced inhibitory activity in mutated Eg5 structures. Although we predict that cells challenged with Arry-520 in the clinical setting are likely to acquire resistance through point mutations in the Eg5-binding site, the data for ispinesib suggest that this resistance mechanism is not scaffold independent as previously thought, and new inhibitors can be designed that retain inhibitory activity in these resistant cells.
Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis
Authors: Eales James M. , Maan Akhlaq A. , Xu Xiaoguang , Michoel Tom , Hallast Pille , Batini Chiara , Zadik Daniel , Prestes Priscilla R. , Molina Elsa , Denniff Matthew , Schroeder Juliane , Bjorkegren Johan L.M. , Thompson John , Maffia Pasquale , Guzik Tomasz J. , Keavney Bernard , Jobling Mark A. , Samani Nilesh J. , Charchar Fadi J. , Tomaszewski Maciej 
Published: September 2019

Objective:
The male-specific region of the Y chromosome (MSY) remains one of the most unexplored regions of the genome. We sought to examine how the genetic variants of the MSY influence male susceptibility to coronary artery disease (CAD) and atherosclerosis.

Approach and Results:

Analysis of 129 133 men from UK Biobank revealed that only one of 7 common MSY haplogroups (haplogroup I1) was associated with CAD—carriers of haplogroup I1 had ≈11% increase in risk of CAD when compared with all other haplogroups combined (odds ratio, 1.11; 95% CI, 1.04–1.18;
P
=6.8×10
−4
). Targeted MSY sequencing uncovered 235 variants exclusive to this haplogroup. The haplogroup I1–specific variants showed 2.45- and 1.56-fold respective enrichment for promoter and enhancer chromatin states, in cells/tissues relevant to atherosclerosis, when compared with other MSY variants. Gene set enrichment analysis in CAD-relevant tissues showed that haplogroup I1 was associated with changes in pathways responsible for early and late stages of atherosclerosis development including defence against pathogens, immunity, oxidative phosphorylation, mitochondrial respiration, lipids, coagulation, and extracellular matrix remodeling.
UTY
was the only Y chromosome gene whose blood expression was associated with haplogroup I1. Experimental reduction of
UTY
expression in macrophages led to changes in expression of 59 pathways (28 of which overlapped with those associated with haplogroup I1) and a significant reduction in the immune costimulatory signal.

Conclusions:

Haplogroup I1 is enriched for regulatory chromatin variants in numerous cells of relevance to CAD and increases cardiovascular risk through proatherosclerotic reprogramming of the transcriptome, partly through
UTY
.
Antagonistic role of the microbiome from a Meloidogyne hapla-suppressive soil against species of plant-parasitic nematodes with different life strategies
Authors: Topalović Olivera , Heuer Holger , Reineke Annette , Zinkernagel Jana , Hallmann Johannes 
Published: September 2019

Summary
In certain soils populations of plant-parasitic nematodes (PPN) decline. Understanding this effect may open up environmentally friendly management options. We identified such a suppressive soil containing virtually no PPN. Inoculated Meloidogyne hapla declined in this soil more than in a control soil and reproduction on tomato was reduced. The extracted soil microbiome alone decreased root invasion of second-stage juveniles (J2) and progeny as well as the native soil. We tested the antagonistic potential against PPN that differ in life strategies. The microbiome was most suppressive against two populations of M. hapla and one population of Pratylenchus neglectus, and least suppressive against M. incognita and the ectoparasite Hemicycliophora conida. In a split-root system with M. hapla, plant-mediated but not direct effects of the microbiome significantly reduced root invasion of J2, while direct exposure of M. hapla to the microbiome significantly affected reproduction. Overall, both plant-mediated and direct effects of the microbiome were responsible for the soil suppressiveness against M. hapla.
The occurrence and structure of radial sieve tubes in the secondary xylem of Aquilaria and Gyrinops
Authors: Luo Bei , Imai Tomoya , Sugiyama Junji , Marsoem Sri Nugroho , Mulyaningsih Tri , Itoh Takao 
Published: September 2019

Abstract
New observations of radial sieve tubes in the secondary xylem of two genera and four species of agarwood — Aquilaria sinensis, A. crasna, A. malaccensis and Gyrinops versteeghii (Thymelaeaceae) — are presented in this study. The earliest radial sieve tubes in Gyrinops are formed in the secondary xylem adjacent to the pith. The radial sieve tubes originate from the vascular cambium and develop in both uniseriate and multiseriate ray tissue. In addition to sieve plates in lateral and end walls, scattered or clustered minute sieve pores are localized in the lateral wall of radial sieve tubes. There is a direct connection between radial sieve tubes in ray tissue and axial sieve tubes in interxylary phloem strands (IP), such as (i) connection by bending of radial sieve tube strands, (ii) connection of two IP strands by an oblique bridge, and (iii) connection of two IP strands at a right angle. The average number of radial sieve tubes and interxylary phloem was found to be 1.7 per mm3 and 9.1 per mm2 in the secondary xylem. Considering the higher frequency of radial sieve tubes with the increasing thickness of the secondary xylem, the direct connections between radial and axial sieve tubes could play a significant role in assisting the translocation of metabolites in Aquilaria and Gyrinops.
Mental Health among Canadian Postsecondary Students: A Mental Health Crisis?
Authors: Wiens Kathryn , Bhattarai Asmita , Dores Ashley , Pedram Pardis , Williams Jeanne V. A. , Bulloch Andrew G. M. , Patten Scott B. 
Published: September 2019

Objective: Recent reports express concerns about a mental health crisis among postsecondary students. These assertions, however, often arise from surveys conducted in postsecondary settings that lack the broader context of a referent group. The objectives of this study were (1) to assess the mental health status of postsecondary students 18 to 25 years old from 2011 to 2017 and (2) to compare the mental health status of postsecondary students to nonstudents. Methods: Prevalence was estimated for a set of mental health outcomes using seven annual iterations of the Canadian Community Health Survey (2011 to 2017). Logistic regression was used to derive odds ratio estimates comparing mental health status among postsecondary students and nonstudents, adjusting for age and sex. Random effects metaregression and meta-analyses techniques were used to evaluate trends in prevalence and odds ratio estimates over time. Results: Over the study period, the prevalence of perceived low mental health, diagnosed mood and anxiety disorders, and past-year mental health consultations increased among female students, whereas binge drinking decreased among male students. With the exception of perceived stress, the odds of experiencing each mental health outcome were lower among postsecondary students compared to nonstudents. Conclusions: These findings do not support the idea that postsecondary students have worse mental health than nonstudents of similar age. The perception of a crisis may arise from greater help-seeking behavior, diminishing stigma, or increasing mental health literacy. Regardless, the observance of these trends provide an opportunity to address a previously latent issue.