bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Cervico-Mandibular Manual Therapy in Patients with Temporomandibular Pain Disorders and Associated Somatic Tinnitus: A Randomized Clinical Trial
Authors: Delgado de la Serna Pablo , Plaza-Manzano Gustavo , Cleland Joshua , Fernández-de-las-Peñas César , Martín-Casas Patricia , Díaz-Arribas María José 
Published: October 2019

AbstractObjectiveThis randomized clinical trial investigated the effects of adding cervico-mandibular manual therapies into an exercise and educational program on clinical outcomes in individuals with tinnitus associated with temporomandibular disorders (TMDs).MethodsSixty-one patients with tinnitus attributed to TMD were randomized into the physiotherapy and manual therapy group or physiotherapy alone group. All patients received six sessions of physiotherapy treatment including cranio-cervical and temporomandibular joint (TMJ) exercises, self-massage, and patient education for a period of one month. Patients allocated to the manual therapy group also received cervico-mandibular manual therapies targeting the TMJ and cervical and masticatory muscles. Primary outcomes included TMD pain intensity and tinnitus severity. Secondary outcomes included tinnitus-related handicap (Tinnitus Handicap Inventory [THI]), TMD-related disability (Craniofacial Pain and Disability Inventory [CF-PDI]), self-rated quality of life (12-item Short Form Health Survey [SF-12]), depressive symptoms (Beck Depression Inventory [BDI-II]), pressure pain thresholds (PPTs), and mandibular range of motion. Patients were assessed at baseline, one week, three months, and six months after intervention by a blinded assessor.ResultsThe adjusted analyses showed better outcomes (all, P &lt; 0.001) in the exercise/education plus manual therapy group (large effect sizes) for TMD pain (η 2 P = 0.153), tinnitus severity (η 2 P = 0.233), THI (η 2 P = 0.501), CF-PDI (η 2 P = 0.395), BDI-II (η 2 P = 0.194), PPTs (0.363 &lt; η 2 P &lt; 0.415), and range of motion (η 2 P = 0.350), but similar changes for the SF-12 (P = 0.622, η 2 P = 0.01) as the exercise/education alone group.ConclusionsThis clinical trial found that application of cervico-mandibular manual therapies in combination with exercise and education resulted in better outcomes than application of exercise/education alone in individuals with tinnitus attributed to TMD.
Physical activity can attenuate, but not eliminate, the negative relationships of high TV viewing with some chronic diseases: findings from a cohort of 60 202 Brazilian adults
Authors: Werneck André O , Oyeyemi Adewale L , Collings Paul J , Cyrino Edilson S , Ronque Enio R V , Szwarcwald Célia L , Sardinha Luís B , Silva Danilo R P 
Published: October 2019

Abstract

Background
This study examined the joint associations of leisure time physical activity and television (TV) viewing time with the prevalence of chronic diseases among Brazilian adults.

Methods
Data from the Brazilian Health Survey, a nationally representative survey conducted in 2013 (n = 60 202; ≥18 years), were used. Time spent in TV viewing and leisure physical activity, physician diagnoses of diabetes, hypertension and heart disease and information on co-variables (chronological age, education, ethnicity, candies/sweets consumption, sodium intake and tobacco smoking) were collected via interview. Descriptive statistics (mean and 95% confidence interval) and logistic regression models were used for etiological analyses.

Results
Physical activity attenuated but did not eliminate the risk associated with high TV viewing for at least one chronic disease in the general population [odds ratio [OR]: 1.29 (1.11–1.50)] and among women [OR: 1.31 (1.09–1.60)], adults [OR: 1.24 (1.05–1.46)] and older adults [OR: 1.63 (1.05–2.53)]. On the other hand, physical activity eliminated the risk associated with high TV viewing for at least one chronic disease among men [OR: 1.24 (0.98–1.58)].

Conclusions
We conclude that physical activity can attenuate but not eliminate the negative effects of high TV viewing on chronic disease among subgroups of Brazilian adults.
Acute renal and splenic infarctions: a review
Authors: Weber E , Grangeon F , Reynaud Q , Hot A , Sève P , Jardel S , Tazarourte K , Fouque D , Juillard L , Salles G , Grange C , Durieu I , Rousset P , Lega J C 
Published: October 2019

Abstract

Background
Renal and splenic infarctions are close entities, with few data concerning their clinical, biological and radiological features.

Aim
The aim of this study was to compare the clinical presentations, etiologies and outcomes of acute renal infarctions (RI) and splenic infarctions (SI).

Design
A retrospective multicentric cohort study included patients of the 6 university hospitals in Lyon with RI, SI, or associated RI-SI infarctions was conducted.

Methods
All consecutive cases diagnosed by CT imaging, between January 2013 and October 2016, were included. The exclusion criteria were causes of infarction that did not require additional investigations.

Results
A total of 161 patients were selected for analysis: 34 patients with RI, 104 patients with SI and 23 patients with both RI-SI. Mean ± SD age of patients was 63.2 ± 16.6 years; 59.6% were male. Only 5/161 (3.1%) were healthy prior to the event. The main symptoms were diffuse abdominal pain (26.4%), followed by nausea/vomiting (18.3%) and fever (16.4%).The causes of RI or SI varied significantly within the three groups. Hypercoagulable state was associated with SI, and embolic disease and arterial injury were associated with RI. Extensive (i.e.>2/3 of organ volume) (OR 6.22, 95%CI 2.0119.22) and bilateral infarctions (OR 15.05, 95%CI 1.79–126.78) were significantly associated with hemodynamic shocks. The survival at 1 month follow-up did not significantly differ between the three groups.

Conclusion
Acute RI and SI are heterogenous entities in regards to their clinical presentation, etiology, associated venous or arterial thrombosis, but prognoses were not different at short term follow-up.
What do we measure with 28-joint DAS in elderly patients? An explorative analysis in the NOR-DMARD study
Authors: van Onna Marloes , Putrik Polina , Lie Elisabeth , Kvien Tore K , Boonen Annelies , Uhlig Till 
Published: October 2019

Abstract

Objective
Insight into the influence of ageing on disease outcomes is limited. The objective of this study was to examine the potential effect of age on disease activity using the 28-joint DAS (DAS28) and its components in patients with RA.

Methods
Baseline data of DMARD-naïve patients with RA from the Norwegian Register of DMARDs were used. Linear regression explored the strength of the association between age (&lt;45, 45–65 and &gt;65 years) and each DAS28 component while accounting for education and gender. Adjusted predicted scores for DAS28 components and total DAS28 score were calculated for each age category.

Results
Baseline data from 2037 patients [mean age 55.2 years (s.d. 14.0), 68% females] were available. Regression models had to be stratified for gender (P for interaction &lt;0.001); education was a significant covariate. Males &gt;65 years of age with an intermediate level of education have a 56% higher ESR and 25% higher 28-joint swollen joint count as compared with their younger counterparts (&lt;45 years). For females, corresponding differences were 51% and 27%, respectively. The age effect on the 28-joint tender joint count and patient global assessment was negligible. In patients with an intermediate education level, DAS28 was 5.0 vs 5.5 (10% increase) in the youngest vs oldest age groups, independent of gender.

Conclusion
The age-related increase in ESR and 28-joint swollen joint count scores without a relevant corresponding increase in 28-joint tender joint count and patient global assessment might imply that age-related processes (e.g. soft tissue changes, physiological ESR increase) contribute to a higher DAS28 in elderly patients.
COMPARISON OF DIFFERENT TECHNIQUES FOR EVALUATION OF DOSE DISTRIBUTIONS IN RADIOTHERAPY USING RADIOCHROMIC EBT3 FILMS
Authors: Dufek V , Horakova I , Koniarova I 
Published: October 2019

Abstract
In radiotherapy, radiochromic films can be used for verification of delivery of dose distributions calculated by treatment planning systems. The main objective of this work was to compare three different techniques for evaluation of dose distributions for prostate cancer treatment plans using radiochromic EBT3 films. These techniques are: red channel evaluation taking into account only a response of irradiated film (R), red channel evaluation taking into account a response of unirradiated and irradiated film (Rcor) and multichannel evaluation in FilmQA software (RGB). Also comparison between film and MatriXX measurement was performed. Comparison showed that gamma analysis passing rates strongly depend on evaluation technique and on a model of scanner for digitizing films. The highest gamma passing rates were obtained with red channel evaluation taking into account a response of unirradiated and irradiated film using Epson V750 scanner (Rcor) and multichannel evaluation in FilmQA using Epson 11000XL scanner.
Investment in innovation for European recovery: A public policy priority
Authors: Archibugi Daniele , Filippetti Andrea , Frenz Marion 
Published: October 2019

AbstractThe 2008 crisis had severe consequences in Europe at many levels. One of them is the significantly lower levels of public and private investments. This article explores to what extent a large plan of public innovation investment could contribute to the overall economic recovery and to opening a new stage of development in the European Union (EU). We argue that key scientific and technological opportunities, currently untapped, exist, which have the potential to accelerate economic growth and to pull in private investments. Decisive instruments, such as the Juncker investment plan and the proposed 2021–7 Framework Programme Horizon Europe, are important steps in that direction. The article concludes by reviving Lundvall’s call for a Council for Innovation and Competence Building that should have the same political weight as the EU Economic and Financial Affairs Council.
Cultivating China’s Cinchona: The Local Developmental State, Global Botanic Networks and Cinchona Cultivation in Yunnan, 1930s–1940s
Authors: Shen Yubin 
Published: October 2019

Summary
This article reconstructs the history of China’s first successful cinchona cultivation programme in Hekou, Yunnan province from the 1930s to 1940s during the Nationalist era (1928–49). I argue that the Hekou programme was initiated by the Yunnan ‘local developmental state’ to control endemic malaria and achieve quinine self-sufficiency. It was expanded during the Sino-Japanese War (1937–45) as part of the national defence project in order to develop Yunnan’s malaria-ridden southwest frontier to provide more resources for the war, as well as to solve broader wartime epidemic crises in southwest China. A closer examination also indicates that the development of the Hekou programme was closely intertwined with global networks of cinchona cultivation and international politics.
Infamy, infamy, I need an indemnity: the nature and enforcement of the trustee’s right of indemnity
Authors: Sherwin Timothy 
Published: October 2019

Abstract
In this article, I consider the nature and enforcement of the trustee’s right of indemnity. I set out the principles underlying the trustee’s right of indemnity; and I assess the recent decisions Meritus Trust Company Limited v Butterfield Trust (Bermuda) Limited (“Meritus v Butterfield”) and Rawlinson & Hunter Trustees SA v Chiddicks (the “Z Trusts” case), dealing with enforcement of the right of indemnity in light of those principles. Finally, I conclude, in line with the Court of Appeal in Z Trusts that the trustee’s right of indemnity is enforceable by way of a lien or charge, in which lien or charge is an equitable proprietary right that has priority over any subsequent transaction, including over a successor trustee’s rights of indemnity.
Measuring the multiple domains of medication nonadherence: findings from a Delphi survey of adherence experts
Authors: Kronish Ian M , Thorpe Carolyn T , Voils Corrine I 
Published: October 2019

Abstract
Consensus on a gold-standard measure of patient medication nonadherence has been elusive, in part because medication nonadherence involves multiple, distinct behaviors across three phases (initiation, implementation, and persistence). To assess these behaviors, multiple measurement approaches may be needed. The purpose of this study was to identify expert-recommended approaches to measuring nonadherence behaviors. Thirty medication nonadherence experts were e-mailed two consecutive surveys. In both, respondents rated their agreement with definitions of nonadherence behaviors and measurement approaches. In the second survey, respondents rated the suitability of each measurement approach for assessing each behavior and identified the optimal measurement approach for each behavior. Consensus was achieved for eight patient medication nonadherence behaviors: not filling initial prescription and not taking first dose (noninitiation); refilling prescription late, missing doses, taking extra doses, taking doses at wrong time, and improperly administering medication (incorrect implementation); and discontinuing medication early (nonpersistence). Consensus was achieved for seven measurement approaches: self-report, prescription fill data, pill count, drug levels, electronic drug monitoring (EDM), smart technology, and direct observation. Self-report questionnaires were most commonly rated “at least somewhat suitable” for measuring behaviors. EDM was rated as optimal for measuring missing doses, taking extra doses, and taking doses at the wrong time. Prescription fill data were rated as optimal for not filling initial prescription, refilling late, and discontinuing. Direct observation was rated as optimal for measuring improper administration. Suitable and optimal measurement approaches varied across nonadherence behaviors. Researchers should select the measurement approach best suited to assessing the behavior(s) targeted in their research.
A new automated stem CO2 efflux chamber based on industrial ultra-low-cost sensors
Authors: Brändle Johannes , Kunert Norbert 
Published: October 2019

Abstract
Tree autotrophic respiratory processes, especially stem respiration or stem CO2 efflux (Estem), are important components of the forest carbon budget. Despite the efforts to investigate the controlling processes of Estem in the last years a considerable lack in our knowledge remains on the abiotic and biotic drivers affecting Estem dynamics. It has been strongly advocated that long-term measurements would shed light into those processes. The expensive scientific instruments needed to measure gas exchange has prevented from applying Estem measurements on a larger temporal and spatial scale. Here, we present an automated closed dynamic chamber system based on inexpensive and industrially broadly applied CO2 sensors reducing the costs for the sensing system to a minimum. The CO2 sensor was cross-calibrated with a commonly used gas exchange system in the laboratory and in the field, and we found very good accordance of these sensors. We tested the system under harsh tropical climatic conditions, characterized by heavy tropical rainfall events, extreme humidity, and temperatures, in a moist lowland forest in Malaysia. We recorded Estem of three Dyera costulata trees with our prototype over various days. The variation of Estem was large among the three tree individuals and varied by 7.5-fold. However, clear diurnal changes in Estem were present in all three tree individuals. One tree showed high diurnal variation in Estem and the relationship between Estem and temperature was characterized by a strong hysteresis. The large variations found within one single tree species highlights the importance of continuous measurement to quantify ecosystem carbon fluxes.
Forest carbon allocation modelling under climate change
Authors: Merganičová Katarína , Merganič Ján , Lehtonen Aleksi , Vacchiano Giorgio , Sever Maša Zorana Ostrogović , Augustynczik Andrey L D , Grote Rüdiger , Kyselová Ina , Mäkelä Annikki , Yousefpour Rasoul , Krejza Jan , Collalti Alessio , Reyer Christopher P O 
Published: October 2019

AbstractCarbon allocation plays a key role in ecosystem dynamics and plant adaptation to changing environmental conditions. Hence, proper description of this process in vegetation models is crucial for the simulations of the impact of climate change on carbon cycling in forests. Here we review how carbon allocation modelling is currently implemented in 31 contrasting models to identify the main gaps compared with our theoretical and empirical understanding of carbon allocation. A hybrid approach based on combining several principles and/or types of carbon allocation modelling prevailed in the examined models, while physiologically more sophisticated approaches were used less often than empirical ones. The analysis revealed that, although the number of carbon allocation studies over the past 10 years has substantially increased, some background processes are still insufficiently understood and some issues in models are frequently poorly represented, oversimplified or even omitted. Hence, current challenges for carbon allocation modelling in forest ecosystems are (i) to overcome remaining limits in process understanding, particularly regarding the impact of disturbances on carbon allocation, accumulation and utilization of nonstructural carbohydrates, and carbon use by symbionts, and (ii) to implement existing knowledge of carbon allocation into defence, regeneration and improved resource uptake in order to better account for changing environmental conditions.
Where Cowboys and Indians Meet: A Southern Cheyenne Web of Kinship and the Transnational Cattle Industry, 1877–1885
Authors: Truden John 
Published: October 2019

Abstract
Between 1877 and 1885, a Southern Cheyenne chief named Stone Calf gathered a coalition of Southern Cheyenne women and men, cultural intermediaries, ranchers, missionaries, and U.S. soldiers together in northwestern Indian Territory. Bound by kinship, gendered labor, economic opportunity, and political necessity, this alliance negotiated the transnational cattle industry’s access to the environmental resources of the Southern Great Plains. Using these powerful ties, Stone Calf’s coalition successfully shaped both the cattle industry’s expansion and displaced the Office of Indian Affairs’ influence in the region. By recognizing Stone Calf’s coalition as a powerful transnational force, this article illuminates both the weight of kinship and Indigenous participation in a globally interconnected world.
Evidence-based interventions cause multifold increase of influenza immunization rates in a free clinic
Authors: Falcone Aimee L. , Vess Joy , Johnson Emily 
Published: October 2019

ABSTRACT

Background:
Every year in the United States, influenza-related infection causes thousands of deaths, the complications of which require millions of dollars in hospital-related care. The influenza vaccine is proven to effectively reduce incidence of infection and complications from influenza viruses.

Local problem:
A clinic in southeast Florida for the uninsured offered influenza immunization at no cost to its patients, yet the immunization rate was still low.

Methods:
A quality improvement project was conducted to determine whether the use of evidenced-based bundled interventions would increase the rate of the influenza vaccination at the clinic.

Interventions:
The bundled interventions included mass communication, leadership, improved work flow, and improved access.

Results:
Evidence-based interventions led to a 597% increase in the influenza uptake rate. Trends were analyzed by using data gathered from the electronic medical record regarding patient demographics, influenza immunization uptake rate, type of visit for the immunizations, and reason for declining. Overcoming the access barrier led to great improvements in this clinic. Initially more vaccines were given in nurse visits; as the season progressed, more vaccines were given by providers in the clinic. Common reasons for patient refusal of the vaccine were fear of side effects and fear of contracting the influenza virus. Streamlined documentation could promote continued staff compliance over time.

Conclusions:
To reduce influenza-related costs and improve health outcomes, it is imperative that nurse practitioners use evidence-based interventions in the practice setting to increase influenza uptake rates in the adult uninsured population.
Recovery of malnutrition in a patient with severe brain injury outcomes
Authors: Caliri Santina , Andaloro Adriana , Corallo Francesco , Donato Antonina , Marino Silvia , Mantarro Carmela , Terranova Aurelio , Bramanti Placido , Caminiti Fabrizia , Rifici Carmela 
Published: October 2019

AbstractRationale:Severe brain injury often induces a state of malnutrition due to insufficient caloric and protein input. If left untreated, it will have a negative impact on rehabilitation. Nutritional therapy provides caloric and the nutritional support necessary to cover the daily needs and help contrast hospital infections. Our hypothesis is that integration of natural foods in the daily diet can enhance the recovery of the state of malnutrition and increase rehabilitation outcomes.Patient concerns:We present the case of a young man with traumatic brain injury caused by a car accident. Who underwent tracheostomy and percutaneous endoscopic gastrostomy (PEG) procedures, had severe consciousness disorder, was severely malnourished and therefore underweight.Diagnosis:He was severely underweight, malnourished, with a severe consciousness disorder that necessitated the tracheostomy and the PEG.Interventions:Our approach included caloric implementation of artificial nutrition and the gradual introduction of semi-liquid natural foods administered through PEG.Outcomes:The patient was followed for a year during which the metabolic/nutritional pattern and the blood tests improved, normal weight restored, and consciousness regained.Conclusion:Nutritional intervention integrated with natural foods, has allowed a gradual increase in weight, a better recovery of the lean mass and the stabilization of the metabolic-nutritional framework.Nutritional approach used has contributed to the reduction of recovery times, making the therapeutic path more effective.
Hepatocellular carcinoma arising from left accessory liver lobe supplied by the branch of left hepatic artery
Authors: Wang Xiaolong , Zhang Qingqiao , Xu Kai 
Published: October 2019

Abstract

Introduction:
Accessory liver lobe (ALL) is a rare congenital anomaly. ALL combined with hepatocellular carcinoma (HCC) is even rarer. Most ALLs with HCC are often located in the right liver, and are not supplied by the left hepatic artery.

Patient concerns:
A 77-year-old man was referred to our hospital because of the level of serum alpha-fetoprotein (AFP) continually increased for 1 month. He had no history of chronic hepatitis, alcohol abuse, or cirrhosis of the liver.

Diagnoses:
Preoperative computed tomography (CT) scan revealed a 3.0 × 3.0 × 1.0 cm ovaloid-shaped solid mass in the left subphrenic area with isodensity. Magnetic resonance imaging (MRI) showed a mass with a heterogeneous signal on T1- and T2-weighted images. On contrast-enhanced CT and MRI, the mass showed a pattern of early enhancement and washout. Digital subtraction angiography (DSA) confirmed the mass was fed by the branch of left liver artery.

Interventions:
The mass was treated by transatheter arterial embolization (TAE) followed by surgical resection. Histopathologically showed HCC, consistent with a moderately differentiated.

Outcomes:
Follow-up of 3 months after surgery, the level of AFP returned to normal gradually.

Conclusions:
In this report, we describe a rare case of ALL with HCC, located in the left subphrenic area, especially which was supplied by the branch of left hepatic artery has rarely been described. The clinical presentation, radiological features are described in the literature.