bluuebunny/crossref_metadata_2025_split huggingface dataset:
Loss of function of Colgalt1 disrupts collagen post-translational modification and causes musculoskeletal defects
Authors: Geister Krista A. , Lopez-Jimenez Alberto Jose , Houghtaling Scott , Ho Tzu-Hua , Vanacore Roberto , Beier David R. 
Published: May 2019

ABSTRACT
In a screen for organogenesis defects in N-ethyl-N-nitrosourea (ENU)-induced mutant mice, we discovered a line carrying a mutation in Colgalt1 [collagen beta(1-O)galactosyltransferase type 1], which is required for proper galactosylation of hydroxylysine residues in a number of collagens. Colgalt1 mutant embryos have not been previously characterized; here, we show that they exhibit skeletal and muscular defects. Analysis of mutant-derived embryonic fibroblasts reveals that COLGALT1 acts on collagen IV and VI, and, while collagen VI appears stable and its secretion is not affected, collagen IV accumulates inside of cells and within the extracellular matrix, possibly due to instability and increased degradation. We also generated mutant zebrafish that do not express the duplicated orthologs of mammalian Colgalt1. The double-homozygote mutants have muscle defects; they are viable through the larvae stage but do not survive to 10 days post-fertilization. We hypothesize that the Colgalt1 mutant could serve as a model of a human connective tissue disorder and/or congenital muscular dystrophy or myopathy.
Selective inhibition of N-linked glycosylation impairs receptor tyrosine kinase processing
Authors: Klaver Elsenoor , Zhao Peng , May Melanie , Flanagan-Steet Heather , Freeze Hudson H. , Gilmore Reid , Wells Lance , Contessa Joseph , Steet Richard 
Published: May 2019

ABSTRACT
Global inhibition of N-linked glycosylation broadly reduces glycan occupancy on glycoproteins, but identifying how this inhibition functionally impacts specific glycoproteins is challenging. This limits our understanding of pathogenesis in the congenital disorders of glycosylation (CDG). We used selective exo-enzymatic labeling of cells deficient in the two catalytic subunits of oligosaccharyltransferase – STT3A and STT3B – to monitor the presence and glycosylation status of cell surface glycoproteins. We show reduced abundance of two canonical tyrosine receptor kinases – the insulin receptor and insulin-like growth factor 1 receptor (IGF-1R) – at the cell surface in STT3A-null cells, due to decreased N-linked glycan site occupancy and proteolytic processing in combination with increased endoplasmic reticulum localization. Providing cDNA for Golgi-resident proprotein convertase subtilisin/kexin type 5a (PCSK5a) and furin cDNA to wild-type and mutant cells produced under-glycosylated forms of PCSK5a, but not furin, in cells lacking STT3A. Reduced glycosylation of PCSK5a in STT3A-null cells or cells treated with the oligosaccharyltransferase inhibitor NGI-1 corresponded with failure to rescue receptor processing, implying that alterations in the glycosylation of this convertase have functional consequences. Collectively, our findings show that STT3A-dependent inhibition of N-linked glycosylation on receptor tyrosine kinases and their convertases combines to impair receptor processing and surface localization. These results provide new insight into CDG pathogenesis and highlight how the surface abundance of some glycoproteins can be dually impacted by abnormal glycosylation.
A Theoretical Basis for the Enhancement of Seebeck Coefficients in Supramolecular Thermocells
Authors: Liang Yimin , Zhou Hongyao , Yamada Teppei , Kimizuka Nobuo 
Published: May 2019

Abstract
Seebeck coefficients (Se) of supramolecular thermocells harnessing four kinds of cyclodextrins as host molecules were investigated. Theoretical analysis revealed that association enthalpy between the hosts and triiodide has a major influence on the Seebeck coefficients of the thermocells. Thermodynamic parameters of host–guest associations were evaluated by isothermal titration calorimetry, which is in good agreement with the theoretically estimated values from thermocell measurements. This result provides a guideline to estimate Seebeck coefficient of supramolecular thermocells and to determine the thermodynamic parameters.
Patterns of emergency department visits during Hajj period: Towards healthcare optimization in view of Saudi Arabia’s vision 2030
Authors: Mirza Ahmad A. , Alsakkaf Mohammed A. , Mohammed Amrallah A. , Mirza Abdulrahim A. , Elmorsy Soha A. 
Published: May 2019

Objective: This study aimed to examine the pattern of emergency department (ED) visits by Hajj patients and determine the urgency of emergency visits at an advanced healthcare center.
Methods: A retrospective review of medical records of Hajj patients visiting the ED at King Abdullah Medical City Makkah from September 1 to October 5, 2015 was conducted.
Results: We considered 233 visits by 199 Hajj patients. Most diseases were cardiovascular related. Approximately half of the ED visits led to hospital admission, which were largely during the evening and nighttime. Potentially avoidable visits were significantly encountered during the daytime. Average bed occupation time in the ED was similar for both cases: those admitted to inpatient care and discharged from ED. Results from the Canadian Triage and Acuity Scale revealed that most patients were triaged with a score of III (48.4%) followed by a clinically better score of IV (32%); however, scores did not change significantly throughout the Hajj day.
Conclusions: During Hajj, a significant proportion of patients who visited the ED at the ultimate healthcare facility were discharged within 24 hours, with a higher rate in the morning-afternoon period. Both admitted and discharged cases required equal levels of care. Therefore, an extension in working days at primary care centers and optimization of advanced healthcare facilities during Hajj is currently warranted.
doi: https://doi.org/10.12669/pjms.35.3.611
How to cite this:Mirza AA, Alsakkaf MA, Mohammed AA, Mirza AA, Elmorsy SA. Patterns of emergency department visits during Hajj period: Towards healthcare optimization in view of Saudi Arabia’s vision 2030. Pak J Med Sci. 2019;35(3):647-652. doi: https://doi.org/10.12669/pjms.35.3.611
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Pricing Risks Across Currency Denominations
Authors: Maurer Thomas A. , Tô Thuy-Duong , Tran Ngoc-Khanh 
Published: May 2019

We use principal component analysis on 55 bilateral exchange rates of 11 developed currencies to identify two important global risk sources in foreign exchange (FX) markets. The risk sources are related to Carry and Dollar but are not spanned by these factors. We estimate the market prices associated with the two risk sources in the cross-section of FX market returns and construct FX market-implied country-specific stochastic discount factors (SDFs). The SDF volatilities are related to interest rates and expected carry trade returns in the cross-section. The SDFs price international stock returns and are related to important financial stress indicators and macroeconomic fundamentals. The first principal risk is associated with the Treasury-EuroDollar (TED) spread, quantities measuring volatility, tail and contagion risks, and future economic growth. It earns a relatively small implied Sharpe ratio. The second principal risk is associated with the default and term spreads and quantities capturing volatility and illiquidity risks. It further correlates with future changes in the long-term interest rate and earns a large implied Sharpe ratio. This paper was accepted by Lauren Cohen, finance.
A qualitative study exploring school nurses' experiences of safeguarding adolescents
Authors: Littler Nadine 
Published: May 2019

Background: An integral aspect of the school nurse's role is in safeguarding; therefore, they are uniquely placed to identify and assess adolescent's health and wellbeing. Aims: The aim of this study is to explore school nurses' experiences of safeguarding adolescence. Methods: A qualitative phenomenological study was undertaken with participants recruited from five NHS trusts across England, involving semi-structured telephone interviews, which were analysed and managed with the ATLASti software using a grounded theory approach. Findings: Four categories were identified in the study, one was related to education, and three were related to the school nursing role. These include targeted interventions, encountering increased numbers of safeguarding risks (such as child sexual exploitation and mental health in practice), and identifying safeguarding supervision and teamwork as key factors of support within their role. Conclusions: This study has provided an insight into the school nurses' role in safeguarding adolescents; however, further research still needs to be undertaken on this multifaceted area of practice.
Implications for school nurses using simulator dolls to manage unplanned teen pregnancy
Authors: Hussain Humaira , Jomeen Julie , Hayter Mark , Tweheyo Ritah 
Published: May 2019

Background: School nurses are key professionals in the promotion of sexual and reproductive health. Aim: The aim of this study is to explore teenagers' perceptions of their practical parenting skills and their attitudes toward experiential learning through the use of high fidelity baby simulators. Methods: Virtual baby simulator dolls were used as part of sex and relationship education with school students (aged 15–16 years) to look after over a weekend. Students were recruited from a UK academy and completed a diary of their experiences while parenting, received quantitative feedback simulator reports and completed a post-study evaluation questionnaire. Findings: Students saw the virtual baby project as beneficial and important in schools and perceived an improvement in their understanding of practical parenting skills, sexual health and contraception. Conclusion: The implications of this paper are toward involving school nurses more actively in sexual health education in schools via the use of high-fidelity simulators as creative pedagogy in PSHE.
Juvenile osteochondritis dissecans (JOCD) of the knee: current concepts review
Authors: Masquijo Javier , Kothari Alpesh 
Published: May 2019

Juvenile osteochondritis dissecans (JOCD) is a joint disorder of the subchondral bone and articular cartilage that affects skeletally immature patients. The aetiology of JOCD is unknown and the natural history is poorly characterized in part due to inconsistent and largely retrospective literature. Most OCD in children and adolescents presents as a stable lesion amenable to non-operative treatment or minimally invasive drilling. However, unstable forms can require a more aggressive approach. This article reviews the most recent literature available and focuses on the pathophysiology, diagnosis and treatment of JOCD of the knee. Cite this article: EFORT Open Rev 2019;4:201-212. DOI: 10.1302/2058-5241.4.180079
Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis
Authors: Levy Alexander N. , Ackerman Rachel , Yilmaz Osman , Jouhourian Caroline , Tandon Manish , Winter Michael W. 
Published: May 2019

ABSTRACT
Hepatoid adenocarcinoma (HA) is a rare malignant tumor of extrahepatic origin that morphologically and immunophenotypically resembles hepatocellular carcinoma. We report a case of rectal HA with hepatic metastasis arising in a 38-year-old male with a history of ulcerative colitis. Despite elevated alpha-fetoprotein, contrast enhancement of the hepatic mass was not consistent with hepatocellular carcinoma. Immunohistochemistry revealed the diagnosis, and the patient was started on palliative chemotherapy. Colorectal HA should be considered when evaluating malignant lesions in the setting of inflammatory bowel disease and can be distinguished from other tumors based on alpha-fetoprotein, imaging, and immunostaining.
The (near) absence of English in Flemish dinner table conversations
Authors: Zenner Eline , Van De Mieroop Dorien 
Published: May 2019

AbstractThis paper studies the low frequency of English insertions in child-directed speech in eight Flemish families, which is striking considering the strong position of English in other domains in Flanders. Crossing usage-based approaches to language acquisition and language socialization research, we scrutinize our corpus of dinner table conversations that consist of over 25,000 utterances, complemented by sociolinguistic interviews with the caregivers of each family. After mining our corpus for English insertions, we present a quantitative exploration that reveals how less than 1% of the utterances per family contain English insertions. Assessing whether this result can be interpreted as parents’ attempts to socialize their children towards Dutch, and what this reveals about their language regards, we analyze selected fragments through multimodal discourse analysis. After discussing possible implications of these findings for the position of English in Flanders, we additionally discuss them against the theoretical background of developmental sociolinguistics, and against the methodological background of working with small samples and negative evidence in a usage-based approach (see e.g. negative entrenchment.
What do doctors advise patients in jokes and why?
Authors: Chłopicki Władysław 
Published: May 2019

AbstractDoctor jokes are one of the most popular kind of jokes because they deal with the very sensitive subject of human state of health which draws upon the very basic life-death dichotomy, listed by Raskin in his influential study (Raskin, Victor. 1985.Semantic mechanisms of humor. Dordrecht: Reidel.) among the dichotomies most common in jokes. At the same time, doctor jokes are culture-specific as they reflect the relations between doctors and patients which are typical of a culture in terms of its power distance relations, especially in institutional encounters. Such differences are emphasized by the linguistic categories, such as official and familiar forms of address or culture-specific lexical items. But the reason certain jokes do not “travel” across language boundary is often not only the language itself, but also the cultural assumptions and relations – this concerns, for instance, the references to drinking or doctors’ ineffectiveness/incompetence in Polish jokes. This study focuses on doctor jokes as a category of jokes popular both in Poland and English-speaking countries, but the broad category of doctor jokes is here restricted to those which express the doctor’s advice: this aims at specifying and comparing the jocular advice scripts, central to the doctor-patient relation in both cultures, setting them against the serious advice script.
Word of Mouth, Viral Marketing and Open Data: A Large-Scale Simulation for Predicting Opinion Diffusion on Ethical Food Consumption
Authors: Bruzzone Agostino G. , Agresta Matteo , Hsien Hsu Jen 
Published: May 2019

Abstract
This paper presents the first results of a large-scale-Agent-Based Simulation devoted to simulate individual behaviour inside a medium sized city (600,000 inhabitants). Humans are simulated as Intelligent Individual entities characterized by several attributes created from the Open Data available by means of a multi-layer approach. The work presented is divided into two main parts: the first part aims to describe the multi-layer approach adopted with the inclusion of the social network layer devoted to capture how social networks can be correlated with human activities and how an “Individual Opinion” can changes based on social interactions. The second part is devoted to present a preliminary case study for simulating the propagation dynamics of the individual opinion in the form of an ethical value function. The basic idea is to capture the changes in the individual opinion based on the social interactions predicted by the simulation. Finally, a food choice model for predicting individual choices based on the individual opinion function is presented; the model is based on three parameters: accessibility of ethical shops, price difference with standard products, and ethical value propagation.
Weighted Variable Exponent Sobolev spaces on metric measure spaces
Authors: Hassib Moulay Cherif , Akdim Youssef 
Published: May 2019

AbstractIn this article we define the weighted variable exponent-Sobolev spaces on arbitrary metric spaces, with finite diameter and equipped with finite, positive Borel regular outer measure. We employ a Hajlasz definition, which uses a point wise maximal inequality. We prove that these spaces are Banach, that the Poincaré inequality holds and that lipschitz functions are dense. We develop a capacity theory based on these spaces. We study basic properties of capacity and several convergence results. As an application, we prove that each weighted variable exponent-Sobolev function has a quasi-continuous representative, we study different definitions of the first order weighted variable exponent-Sobolev spaces with zero boundary values, we define the Dirichlet energy and we prove that it has a minimizer in the weighted variable exponent -Sobolev spaces case.
Harmonic numbers, harmonic series and zeta function
Authors: Sebbar Ahmed 
Published: May 2019

AbstractThis paper reviews, from different points of view, results on Bernoulli numbers and polynomials, the distribution of prime numbers in connexion with the Riemann hypothesis. We give an account on the theorem of G. Robin, as formulated by J. Lagarias. The other parts are devoted to the series𝒨is(z)=∑n=1∞μ(n)nszn$\mathcal{M}{i_s}(z) = \sum\limits_{n = 1}^\infty {{{\mu (n)} \over {{n^s}}}{z^n}} $. A significant result is that the real partfof∑μ(n)ne2inπθ$$\sum {{{\mu (n)} \over n}{e^{2in\pi \theta }}}$$is an example of a non-trivial real-valued continuous functionfon the real line which is 1-periodic, is not odd and has the property∑h=1nf(h/k)=0$\sum\nolimits_{h = 1}^n {f(h/k) = 0}$for every positive integerk.
A few results on some nonlinear parabolic problems in Orlicz-Sobolev spaces
Authors: Redwane Hicham 
Published: May 2019

Abstract
In this paper, we present our results (see our papers), which concern the existence of the renormalized solutions for equations of the type:

∂
b
(
x
,
u
)

∂
t

-
div

(

a
(
x
,
t
,
u
,
∇
u
)

)

-
div

(

Φ

(

x
,
t
,
u

)

)

=
f

in

Q
=
Ω
×
(
0
,
T
)
,

$${{\partial b(x,u)} \over {\partial t}} - {\rm{div}}\left( {a(x,t,u,\nabla u)} \right) - {\rm{div}}\left( {\Phi \left( {x,t,u} \right)} \right) = f\,\,\,{\rm{in}}\,Q = \Omega \times (0,T),$$

where b(x, ·) is a strictly increasing C
1-function for any x ∈ Δ, a(x, t, s, ξ) and Φ(x, t, s) are a Carathéodory functions. The function f is in L
1(Q).
Existence of Solutions for Some Nonlinear Elliptic Anisotropic Unilateral Problems with Lower Order Terms
Authors: Akdim Youssef , Allalou Chakir , Salmani Abdelhafid 
Published: May 2019

AbstractIn this paper, we prove the existence of entropy solutions for anisotropic elliptic unilateral problem associated to the equations of the form-∑i=1N∂iai(x,u,∇u)-∑i=1N∂iφi(u)=f,$$ - \sum\limits_{i = 1}^N {{\partial _i}{a_i}(x,u,\nabla u) - } \sum\limits_{i = 1}^N {{\partial _i}{\phi _i}(u) = f,} $$where the right hand sidefbelongs toL1(Ω). The operator-∑i=1N∂iai(x,u,∇u)$- \sum\nolimits_{i = 1}^N {{\partial _i}{a_i}\left( {x,u,\nabla u} \right)} $is a Leray-Lions anisotropic operator andϕi∈C0(ℝ,ℝ).
Plasmon-enhanced solar vapor generation
Authors: Liang Jie , Liu Haizhou , Yu Jianyu , Zhou Lin , Zhu Jia 
Published: May 2019

Abstract
Plasmonic nanostructures with strong light-matter interactions have been intensively explored in the past decades. The plasmonic photothermal effect has garnered significant research interest and triggered plenty of applications, such as photothermal therapy, photothermal imaging, and photocatalysis. Recently, plasmonic nanostructures are emerging as one of the most exciting candidates for solar vapor generation, inspiring the revival of solar-thermal-based water purification technologies. Here we present a review of state-of-the-art plasmonic-enhanced solar evaporation, including the theoretical background, various designs of plasmonic materials and structures, and their potential applications. The current challenges and future perspective are outlined as well.
Crystal structure of 1-nonylpyridazin-1-ium iodide, C13H23N2I
Authors: Said Musa A. , Hughes David L. , Almutairi Saud M. , Aouad Mohamed Reda , Messali Mouslim 
Published: May 2019

Abstract
C13H23N2I, triclinic, P1̄ (no. 2), a = 5.6693(3) Å, b = 8.9457(4) Å, c = 16.2919(7) Å, α = 83.341(4)°, β = 89.534(4)°, γ = 82.491(4)°, V = 813.63(7) Å3, Z = 2, R
gt(F) = 0.0446, wR
ref(F
2) = 0.0873, T = 295(2) K.
Representation of the soundscape quality in urban areas through colours
Authors: Puyana-Romero Virginia , Ciaburro Giuseppe , Brambilla Giovanni , Garzón Christiam , Maffei Luigi 
Published: May 2019

AbstractNoise mapping is a useful and widespread method to visualise various items like the exposure to noise pollution, statistics of affected population, different noise source contribution analysis, and it is also a useful tool in designing noise-control plans. Some researches have moved a step further, proposing maps to represent the people perception of the acoustic environment. Most of these maps use colours as mere tools to display the spatial variability of acoustic parameters. In this paper the colours associated by interviewed people to different urban soundscapes have been analysed, and the possibility of using meaningful colours to represent the soundscape quality in noise mapping has been examined. For this purpose, correspondence analysiswas applied on the data collected fromon-site interviews, performed in the water front of Naples and its surroundings. The outcomes show that in the pedestrian areas nearby the sea, the blue colour was often associated with the soundscape rating, whereas in the areas nearby the sea but open to road traffic the interviewees selected mainly the blue and grey colours. In the areas away from the sea, a wider selection of colours was observed: red and greywere predominantly selected in the areas open to road traffic and green, yellow and red in the green areas.
The Absconditive revealed: Attention alignment in the grammar of Coastal Marind
Authors: Olsson Bruno 
Published: May 2019

AbstractSpeakers of Coastal Marind, a Papuan language of the Anim family, use a special inflectional form of the verb to signal that the state of affairs that the verb describes is outside the addressee’s current focus of attention. A central claim of the paper is that speakers use this verb form, which I call theAbsconditive, to signal that the addressee should realign their attention to achieve shared access to the state of affairs. The paper describes the function of this attentional-epistemic grammatical category and provides examples of its use, mostly drawn from video recordings of face-to-face interaction. I also contrast the Absconditive with constructions with related functions, such as the use of morphology expressing information-structural notions (narrow focus), and a verb form that appears to express shared access to a referent.