bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Expression Pattern of SEMA3F Depending on Endometrial Cancer Grade - Pilot Study
Authors: Dziobek Konrad , Opławski Marcin , Grabarek Beniamin , Zmarzły Nikola , Kiełbasiński Robert , Leśniak Ewa , Januszyk Piotr , Januszyk Krzysztof , Adwent Iwona , Dąbruś Dariusz , Kieszkowski Przemysław , Kiełbasiński Kamil , Kuś-Kierach Agnieszka , Boroń Dariusz 
Published: June 2019

Background:
In the course of neoplastic diseases, a reduction in SEMA3F expression is observed,
which translates into an increase in the proliferative and proangiogenic potential of cells forming
the tumor and the surrounding microenvironment.

Objective:
The aim of this study was to determine the changes in SEMA3F level in endometrial cancer
depending on its grade.

Methods:
The study material consisted of tissue samples: 15 without neoplastic changes (control
group) and 45 with endometrial cancer (G1, 17; G2, 15; G3, 13; study group). SEMA3F expression
was assessed using the immune-histochemical method.

Results:
The expression of SEMA3F was observed in the control group (Me = 159.38) and in the study
group (G1, Me = 121.32; G2, Me = 0; G3, Me = 130.37). Differences between each grade and control
and between individual grades were statistically significant. There were no significant correlations between
SEMA3F expression and weight and Body Mass Index (BMI). The reduced SEMA3F expression
in tumor tissue compared to healthy tissue indicates that this protein plays key roles in proliferation
and angiogenesis.

Conclusion:
We found that depending on the severity of the disease, cancer adopts different survival
strategies, where SEMA3F plays an important role. As a molecular marker, SEMA3F is not sensitive
to weight and BMI.
Flavonoid-derived Privileged Scaffolds in anti-Trypanosoma brucei Drug Discovery
Authors: Boniface Pone Kamdem , Elizabeth Ferreira Igne 
Published: June 2019

Objective:
Human African Trypanosomiasis (HAT), also known as sleeping sickness is
one of the 20 neglected tropical diseases listed by the World Health Organization, which lead to death
if left untreated. This disease is caused by Trypanosoma brucei gambiense, which is the chronic form
of the disease present in western and central Africa, and by T. brucei rhodesiense, which is the
acute form of the disease located in eastern and southern Africa. Many reports have highlighted the
effectiveness of flavonoid-based compounds against T. brucei.

Methods:
A literature search was conducted for naturally occurring and synthetic anti-T brucei flavonoids
by referencing textbooks and scientific databases (SciFinder, PubMed, Science Direct,
Wiley, ACS, SciELO, Google Scholar, Springer, among others) from their inception until February
2019.

Results:
The present review summarizes the current standings and perspectives for the use of flavonoids
as lead compounds for the potential treatment of HAT.

Conclusion:
Flavonoids isolated from different parts of plants and species were reported to exhibit moderate
to high in vitro antitrypanosomal activity against T. brucei. In addition, synthetic flavonoids revealed
anti-T. brucei activity. Molecular interactions of bioactive flavonoids with T. brucei protein
targets showed promising results.
PI3K/ Akt/ mTOR Pathway as a Therapeutic Target for Colorectal Cancer: A Review of Preclinical and Clinical Evidence
Authors: Narayanankutty Arunaksharan 
Published: June 2019

Background:
Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival. Overexpression of
the PI3K/Akt/mTOR signalling has been reported in various forms of cancers, especially in colorectal
cancers (CRC). Due to their significant roles in the initiation and progression events of colorectal cancer,
they are recognized as a striking therapeutic target.

Objective:
The present review is aimed to provide a detailed outline on the role of PI3K/Akt/mTOR
pathway in the initiation and progression events of colorectal cancers as well as its function in drug
resistance. Further, the role of PI3K/Akt/mTOR inhibitors alone and in combination with other chemotherapeutic
drugs, in alleviating colorectal cancer is also discussed. The review contains preclinical
and clinical evidence as well as patent literature of the pathway inhibitors which are natural
and synthetic in origin.

Methods:
The data were obtained from PubMed/Medline databases, Scopus and Google patent literature.

Results:
PI3K/Akt/mTOR signalling is an important event in colorectal carcinogenesis. In addition, it
plays significant roles in acquiring drug resistance as well as metastatic initiation events of CRCs.
Several small molecules of natural and synthetic origin have been found to be potent inhibitors of
CRCs by effectively downregulating the pathway. Data from various clinical studies also support
these pathway inhibitors and several among them are patented.

Conclusion:
Inhibitors of the PI3K/mTOR pathway have been successful for the treatment of primary
and metastatic colorectal cancers, rendering the pathway as a promising clinical cancer therapeutic target.
Self-microemulsifying Drug Delivery System for Problematic Molecules: An Update
Authors: Singh Dilpreet , Tiwary Ashok K. , Bedi Neena 
Published: June 2019

Background:
The poor bioavailability of a problematic molecule is predominantly due to its
high lipophilicity, low solubility in gastric fluids and/or high fist pass metabolism. Self microemulsifying
drug delivery system (SMEDDS), a lipidic type IV nano-formulation has been of interest in the
field of pharmaceutical research due to its potential for tailoring the physicochemical properties of
pharmaceutical molecules.

Methods:
This review provides insights on various recent innovations and reports from the past seven
years (2012-2019) of self-emulsifying formulations for the delivery of various types of poorly soluble
drugs, phytoconstituents and high molecular peptides and gives exhaustive details of the outcome of
the endeavors in this field.

Results:
Various types of innovative formulations have been molded from SMEDDS like selfemulsifying
powders, granules, tablets, pellets, eutectic and cationic formulations. Till date, many research
reports and patents have been filed on self-emulsifying dosage forms and many formulations
have gained US-FDA approvals which are summarized in the review article.

Conclusion:
This review content highlighted the increasing scope of SMEDDS in augmenting the
physiochemical properties of an API, the variegated formulation types and the attributes of API that
can be improved by SMEDD based formulations.
Trauma and Black Male Adolescents: A Critical Link
Authors: Singletary Gilbert 
Published: June 2019

Background:By the year 2020, children of color will become the majority of those 18 years of age and under in United States. There is a dearth of research that investigates the developmental trajectories of children of color, especially those who live in communities where they are exposed to traumatic events. African American males reared in poverty and/or living in violent communities are an especially vulnerable group.Methods:This paper examines the unique experiences of Black male adolescents and their emotional, psychological, and neurobiological responses to trauma.Discussion:Trauma has multifaceted effects on the lives of Black males. Behavioral disturbances can result in exclusion from school, leading to further traumatization and deprivation. Much of what appears to be antisocial behavior is in fact adaptive response to living in violent communities. It is important to consider the role of this complex interweaving of circumstances in understanding the development of this vulnerable group.
Gender Differences in the Suicide Attempts of Adolescents in Emergency Departments: Focusing on Individuals with Autism Spectrum Disorder
Authors: Mikami Katsunaka , Inomata Seiji , Onishi Yuichi , Orihashi Yasushi , Yamamoto Kenji , Matsumoto Hideo 
Published: June 2019

Background:
Few studies on gender-based diagnostic characteristics of adolescent
suicide attempters in emergency departments (EDs) have included individuals with
autism spectrum disorder (ASD).

Objective:
This study aimed to examine the clinical features of adolescent suicide attempts in
EDs, focusing on gender differences and considering individuals with ASD.

Method:
Ninety-four adolescent patients, aged less than 20 years, who had attempted suicide
and had been hospitalized in an emergency department, participated in this study. Psychiatric
diagnoses according to DSM-IV criteria and clinical features were compared between
male and female patients.

Results:
The number (%) of males was 15 (16.0), and that of females was 79 (84.0). The mean
age (SD) of males was 17.1 (1.5), and that of females was 16.9 (1.6). The attempt methods
were more serious, length of stay in the emergency room longer, and rate of outpatient treatment
lower in males. In addition, suicide attempters with ASD were significantly more frequent
in male. Adjusting for age and gender, adjustment disorder was significantly associated with
the presence of suicide attempters with ASD using a multivariable logistic regression.

Conclusion:
Males were less likely to visit psychiatric service previous to attempting suicides,
and may be likely to complete suicides. In addition, suicide attempters with ASD are
characteristic in male, and likely to have comorbid adjustment disorder. ED visits offer a
window of opportunity to provide suicide prevention interventions for adolescents, and
therefore, psychiatrists in EDs have a crucial role as gatekeepers of preventing suicide reattempts,
especially in adolescent males including individuals with ASD having adjustment
disorder.
Green Synthesis, Characterization and Antimicrobial Activity of Silver Nanoparticles Using Dudoa (Hydnocarpus alcalae C.DC.) Leaf Extract As a Reducing and Stabilizing Agent
Authors: Bragais Edward K.B. , Labaclado Lynne M. 
Published: June 2019

Background and Objective:
In this study, dudoa (Hydnocarpus alcalae C.DC.) leaf extract
was used as a reducing and stabilizing agent in a novel one-step green synthesis of silver nanoparticles.
Dudoa is an endemic plant in the province of Legazpi, Philippines and its seed oil was used as an
anti-leprotic drug.

Method:
Therefore, the dudoa leaf extract was used to synthesize silver nanoparticles. Moreover, optimization
of various parameters greatly affected the size and morphology of the synthesized AgNPs
as indicated by the Ultraviolet-visible (UV-vis) spectrophotometry. The synthesized AgNPs were further
characterized using spectral analyses such as XRD, EDX, SEM, FT-IR, TGA and DLS. The antimicrobial
activity of synthesized AgNPs was also demonstrated.

Results and Discussions:
The synthesized AgNPs exhibited a diffraction pattern and a particle size
ranging from 22-48 nm. The AgNPs also showed complete inhibitory and mild reactivity against representative
pathogenic gram-positive (S.aureus) and gram-negative (E.coli) bacteria.

Conclusion:
Silver nanoparticles were successfully synthesized using H. alcalae leaf extract. Furthermore,
this green synthesis approach appeared to be cost-effective, non-toxic, and eco-friendly
which is a best alternative to the conventional chemical methods.
Predictors of Walking App Users With Comparison of Current Users, Previous Users, and Informed Nonusers in a Sample of Dutch Adults: Questionnaire Study
Authors: De Bruijn Gert-Jan , Dallinga Joan Martine , Deutekom Marije 
Published: June 2019

Background
The last decade has seen a substantial increase in the use of mobile health apps and research into the effects of those apps on health and health behaviors. In parallel, research has aimed at identifying population subgroups that are more likely to use those health apps. Current evidence is limited by two issues. First, research has focused on broad health apps, and little is known about app usage for a specific health behavior. Second, research has focused on comparing current users and current nonusers, without considering subgroups of nonusers.

Objective
We aimed to provide profile distributions of current users, previous users, and informed nonusers, and to identify predictor variables relevant for profile classification.

Methods
Data were available from 1683 people who participated in a Dutch walking event in Amsterdam that was held in September 2017. They provided information on demographics, self-reported walking behavior, and walking app usage, as well as items from User Acceptance of Information Technology, in an online survey. Data were analyzed using discriminant function analysis and multinomial logistic regression analysis.

Results
Most participants were current walking app users (899/1683, 53.4%), while fewer participants were informed nonusers (663/1683, 39.4%) and very few were previous walking app users (121/1683, 7.2%). Current walking app users were more likely to report walking at least 5 days per week and for at least 30 minutes per bout (odds ratio [OR] 1.44, 95% CI 1.11-1.85; P=.005) and more likely to be overweight (OR 1.72, 95% CI 1.24-2.37; P=.001) or obese (OR 1.49, 95% CI 1.08-2.08; P=.005) as compared with informed nonusers. Further, current walking app users perceived their walking apps to be less boring, easy to use and retrieve information, and more helpful to achieve their goals. Effect sizes ranged from 0.10 (95% CI 0.08-0.30) to 1.58 (95% CI 1.47-1.70).

Conclusions
The distributions for walking app usage appeared different from the distributions for more general health app usage. Further, the inclusion of two specific subgroups of nonusers (previous users and informed nonusers) provides important information for health practitioners and app developers to stimulate continued walking app usage, including making information in those apps easy to understand and making it easy to obtain information from the apps, as well as preventing apps from becoming boring and difficult to use for goal attainment.
Mapping the Access of Future Doctors to Health Information Technologies Training in the European Union: Cross-Sectional Descriptive Study
Authors: Giunti Guido , Guisado-Fernandez Estefania , Belani Hrvoje , Lacalle-Remigio Juan R 
Published: June 2019

Background
Health information technologies (HITs) such as electronic health records (EHR) and telemedicine services are currently used to assist clinicians provide care to patients. There are many barriers to HIT adoption, including mismatches between investments and benefits, disruptions in the workflow, and concerns about privacy and confidentiality. The lack of HIT training of health professionals as a workforce is an increasingly recognized and understudied barrier.

Objective
The purpose of this study is to describe what courses on HIT topics are available at the graduate level for future health professionals in the European Union (EU) and to explore possible determining factors for their exposure to these courses.

Methods
A cross-sectional descriptive study of EU medical schools was performed to explore the prevalence of HIT courses. The curricula of all identified higher learning institutions that offer a medical degree were manually explored to identify graduate-level courses that offer specific training on HIT topics. HIT topics were defined as courses or subjects that provided knowledge on the design, development, use, and implementation of HIT. Associations among potential factors such as population, yearly medical graduates, total number of physicians, EHR presence, and gross domestic product (GDP) were explored.

Results
A total of 302 medical schools from the 28 member states of the EU were explored. Only about one-third (90/302, 29.80%) of all medical degree curricula offered any kind of HIT course at the graduate level; in the medical schools that offered HIT courses, the courses were often mandatory (58/90, 64.44%). In most EU countries, HIT courses are offered in less than half of the medical schools, regardless of the country’s GDP per capita. Countries with the highest percentages of HIT course presence have the lowest GDP per capita. There seems to be a weak inverse correlation (–0.49) between the two variables (GDP per capita and HIT course presence). There is a trend between the availability of medical human resources and an increase in the presence of HIT courses, with Romania, Croatia, and Greece as outliers in this respect.

Conclusions
The current state of medical training in the EU leaves much room for improvement. Further studies are required for in-depth analysis of the content and manner of instruction that would fit present and future needs of HIT.
Pioneerityötä rajakarjalaisen onomastiikan alalla
Authors: Sarhimaa Anneli 
Published: June 2019

Arvioitu teos:
Outi Patronen: Rajakarjalaisen sukunimistön kehittyminen osana Suomen karjalankielisen ortodoksivähemmistön suomalaistumista 1818–1920. Helsingin yliopisto 2017. 519 s. isbn 978-951-51-3641-1.
NATIONAL SUBSCRIPTION AND LIBRARY ACQUISITION. PART TWO. THE PRINT AND ELECTRONIC BOOK ACQUISITION IN RUSSIA. STRUCTURE OF RUSSIAN MARKETS OF SCHOLARLY INFORMATION
Authors: Razumova I. K. 
Published: June 2019

Introduction. The national-level subscription to the global citation indexes Web of Science Core Collection and Scopus and the Freedom Collection of Elsevier released 70% of the electronic acquisition expenditures in the Russian libraries. The article aims at the analysis of the changes in the scope and structure of the book and electronic/print book acquisition budgets in the Russian libraries upon the state-funded national subscription. The article studies changes in the structure of the Russian markets of scholarly information broken in different reference groups.Materials and Methods. The article employs statistical analysis of the survey results. Materials comprise results of the data processing of the Russian surveys on the acquisition budgets in 2016–2018 and published results of the international surveys. We analyze three main reference groups and four sub-groups of the Russian institutions. Results obtained in Russia are compared with the results for American academics.Results. Our findings show that the acquisition budgets of Russian institutions demonstrate a shift towards the book and print book acquisition. Both trends differ from the international ones and the 2022 forecasts of the American libraries. The markets of electronic scholarly information show continuous concentration to the segment of universities. In 2018, relative shares of the university segment of the markets of electronic resources and electronic books made correspondingly 94% and 99%. In the electronic book market, the share of the reference group of the universities of the 5/100 project increased from 24% to 32%, whereas the share of two national universities shrank from 24% to 14%.Discussion and Conclusions. The results obtained probably indicate the effect of the national subscription on the library acquisition. The loss in the market positions of the group of Russian national universities can change leaders in the field of research output.
PENINGKATAN HASIL BELAJAR DENGAN MODEL PROBLEM BASED LEARNING PADA MATERI FLUIDA STATIS
Authors: Manik Erwin , Tampubolon Togi 
Published: June 2019

Penelitian ini bertujuan untuk mengetahui pengaruh model problem based learning (PBL) terhadap hasil belajar siswa pada materi pokok Fluida Statis di kelas XI semester II SMA Swasta Raksana Medan T.P. 2017/2018. Jenis penelitian ini adalah quasi exsperiment. Desain penelitian yang digunakan adalah two group pretest-posttest. Populasi dalam penelitian adalah seluruh siswa kelas XI yang terdiri dari 3 kelas yang dipilih dengan cara teknik random sampling. Kelas XI IPA 1 sebagai kelas eksperimen yang berjumlah 35 orang dan XI IPA 2 sebagai kelas kontrol yang berjumlah 31 orang. Instrumen yang digunakan essai dengan jumlah 8 soal yang telah dilakukan uji persyaratan tes untuk mengukur hasil belajar. Hasil penelitian menunjukkan bahwa nilai rata-rata pretest kelas eksperimen sebesar 11,18 dan kelas kontrol sebesar 11,29. Uji t menunjukkan bahwa kemampuan awal siswa kedua sampel. Nilai rata-rata postes kelas eksperimen sebesar 77,39 dan kelas kontrol sebesar 68,71. Uji t menunjukkan ada pengaruh yang signifikan akibat penerapan model problem based learning (PBL) terhadap hasil belajar siswa pada materi pokok Fluida Statis.Kata kunci : Problem based learning (PBL), hasil belajar, Fluida Statis
EFEKTIVITAS MODEL LEARNING CYCLE 7E BERBANTUAN E-MODUL UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS PESERTA DIDIK SMP
Authors: Desty Sugiharti Sapta , Supriadi Nanang , Andriani Siska 
Published: June 2019

This research aimed to findout the effectiveness of learning cycle 7e assisted e-modul to improve critical thinking skill of Junior High School of students. This research used the quasy experimental design with three classed as sample, VII A as first experiment class, VII B as second experiment class, andVII C as control class. The data were used in this research are the result of pretest and n-gain scores. Data were analyzed by one way Anova and Scheffe test. Based on the result of the Scheffe test, it is knownthe models learning is togive the impact of a diffirent order to enhance the ability of the critical thinking skill. The mean of N-Gain at first experiment class was 0,829, at second experiment class was 0,693, and control class was 0,571. Based on the mean of N-Gain, it can be concluded that learning cycle 7e assisted e-modul was the most effective model to improve critical thinking skill of Junior High School students.
Populus erratica Sachse, nom. nov. – not really new, but a stratigraphically informative species from the late Oligocene and early Miocene of Central Europe
Authors: Sachse Markus 
Published: June 2019

Abstract
A critical review of reports from European localities reveals that the herein newly described Populus erratica Sachse, nom. nov. was previously treated under a variety of names. Due to its stratigraphical range from the late Oligocene to early Miocene, it might be a useful tool for age determinations in the terrestrial record. So far it is known only from warm-temperate floodplain forests in Central Europe – possibly even restricted to the alpine area. The taxonomic relationships to some morphologically similar species from other localities cannot be entirely clarified here.
Potential methane production and oxidation along the soil chronosequence of the Rotmoos glacier forefield
Authors: Prem Eva Maria , Praeg Nadine , Hofmann Katrin , Wagner Andreas Otto , Illmer Paul 
Published: June 2019

Summary
Five differently developed soils aged 6, 35, 80, 150, and >5000 years with the same bedrock and the same (current) climate conditions were chosen to assess abiotic and enzymatic properties as well as methanogenic and methanotrophic activities. Most abiotic properties (dry weight, pH, soil organic matter, and ammonium content), enzyme activities (dehydrogenase [DH] activity, ammonification [AM] rate, dimethylsulfoxide reduction), and potential methane oxidation (PoMO) per gram of dry weight (DW) increased with soil age. In contrast, potential methane production (PoMP) as well as the nitrate content per gram of DW and most enzymatic properties per gram of soil organic matter (SOM) did not increase with soil age but reached its maximum in the middle-aged soils (80–150 years). Our results show that (i) microbial activity does not consequently increase with SOM content/soil age; (ii) methane production can be measured in undeveloped soils, whereas methane oxidation is more restricted to fully developed soils; and (iii) certain soil modifications (change in water content, ammonium addition) could influence potential methane production/oxidation. When considering the concurrent release of raw soil because of the melting of perpetual ice, these data could help to better understand and assess the consequences of global change.