bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms
Authors: Schischlik Fiorella , Jäger Roland , Rosebrock Felix , Hug Eva , Schuster Michael , Holly Raimund , Fuchs Elisabeth , Milosevic Feenstra Jelena D. , Bogner Edith , Gisslinger Bettina , Schalling Martin , Rumi Elisa , Pietra Daniela , Fischer Gottfried , Faé Ingrid , Vulliard Loan , Menche Jörg , Haferlach Torsten , Meggendorfer Manja , Stengel Anna , Bock Christoph , Cazzola Mario , Gisslinger Heinz , Kralovics Robert 
Published: May 2019

Abstract
Ph-negative myeloproliferative neoplasms (MPNs) are hematological cancers that can be subdivided into entities with distinct clinical features. Somatic mutations in JAK2, CALR, and MPL have been described as drivers of the disease, together with a variable landscape of nondriver mutations. Despite detailed knowledge of disease mechanisms, targeted therapies effective enough to eliminate MPN cells are still missing. In this study of 113 MPN patients, we aimed to comprehensively characterize the mutational landscape of the granulocyte transcriptome using RNA sequencing data and subsequently examine the applicability of immunotherapeutic strategies for MPN patients. Following implementation of customized workflows and data filtering, we identified a total of 13 (12/13 novel) gene fusions, 231 nonsynonymous single nucleotide variants, and 21 insertions and deletions in 106 of 113 patients. We found a high frequency of SF3B1-mutated primary myelofibrosis patients (14%) with distinct 3′ splicing patterns, many of these with a protein-altering potential. Finally, from all mutations detected, we generated a virtual peptide library and used NetMHC to predict 149 unique neoantigens in 62% of MPN patients. Peptides from CALR and MPL mutations provide a rich source of neoantigens as a result of their unique ability to bind many common MHC class I molecules. Finally, we propose that mutations derived from splicing defects present in SF3B1-mutated patients may offer an unexplored neoantigen repertoire in MPNs. We validated 35 predicted peptides to be strong MHC class I binders through direct binding of predicted peptides to MHC proteins in vitro. Our results may serve as a resource for personalized vaccine or adoptive cell–based therapy development.
Psychosocial factors at work, personality traits and depressive symptoms
Authors: Paterniti S. , Niedhammer I. , Lang T. , Consoli S. M. 
Published: May 2019

BackgroundAn association between stressful job conditions and depressive symptoms has been reported. This association could be explained by personality traits.AimsTo examine the relationship between psychosocial factors at work and changes in depressive symptoms, taking into account personality traits.MethodThe role of occupational characteristics, psychosocial stress and personality traits in predicting an increase of depressive symptoms was evaluated in 7729 men and 2790 women working at the French National Electricity and Gas Company, with a 3-year follow-up.ResultsIn men, high decision latitude was predictive of a decrease in the Centre for Epidemiologic Studies — Depression scale (CES-D) scores. In both genders, high job demands and low social support at work were predictive of increased scores, irrespective of personality traits and covariates.ConclusionsAdverse psychosocial work conditions are predictors of depressive symptom worsening, independent of personality traits.
The Travesti Critique of the Gender Identity Law in Argentina
Authors: De Mauro Rucovsky Martín , Russell Ian 
Published: May 2019

Abstract
This article reviews the immediate travesti critique of the Argentine Gender Identity Law (law 26,743) in May 2012. Based on what was developed by Marlene Wayar, as an example of sudaca criticism and internal blasphemy, the travesti critique points out that the law does not recognize the specificity of the transvestite identity or its patent inequality, and it reintroduces the binary man/woman categories because it is capable of sanctioning only on the basis of a general population and within a liberal framework of state recognition. In this article the travesti critique of the Gender Identity Law is taken up to indicate a terrain of interrogations and challenges where the law becomes an instance of politicization, that is, where it becomes a field of strategic action and agency, but also a social tool and an instance of resistance, rejoinder, and reply.
Giuseppe Campuzano's Afterlife
Authors: Machuca Rose Malú 
Published: May 2019

Abstract
The following hybrid essay contributes to, as well as complicates, the afterlife of Giuseppe Campuzano's work on travesti as methodology and offers questions raised from community organizing and collective care in order to claim a legacy of travesti as curandera (healer). This is made evident as the essay weaves through an affective history of AIDS-related struggles in life and death and the networks of care they invoke, including Campuzano's own, in order to move through questions of need, desire, collaboration, and urgency for gender and sexual dissidents in the Global South. These reflections result in a specific theorizing that challenges traditional forms knowledge production and creates possibilities through which to enact queer futures that enhance our commitment to one another's survival.
Live imaging of ERK signalling dynamics in differentiating mouse embryonic stem cells
Authors: Deathridge Julia , Antolović Vlatka , Parsons Maddy , Chubb Jonathan R. 
Published: May 2019

ABSTRACT
Stimulation of the ERK/MAPK pathway is required for the exit from pluripotency and onset of differentiation in mouse embryonic stem cells (ESCs). The dynamic behaviour of ERK activity in individual cells during this transition is unclear. Using a FRET-based biosensor, we monitored ERK signalling dynamics of single mouse ESCs during differentiation. ERK activity was highly heterogeneous, with considerable variability in ERK signalling between single cells within ESC colonies. Different triggers of differentiation induced distinct ERK activity profiles. Surprisingly, the dynamic features of ERK signalling were not strongly coupled to loss of pluripotency marker expression, regardless of the differentiation stimulus, suggesting the normal dynamic range of ERK signalling is not rate-limiting in single cells during differentiation. ERK signalling dynamics were sensitive to the degree of cell crowding and were similar in neighbouring cells. Sister cells from a mitotic division also showed more similar ERK activity, an effect that was apparent whether cells remained adjacent or moved apart after division. These data suggest a combination of cell lineage and niche contributes to the absolute level of ERK signalling in mouse ESCs.
Effects of subthalamic deep brain stimulation on striatal metabolic connectivity in a rat hemiparkinsonian model
Authors: Apetz Nadine , Kordys Elena , Simon Mascha , Mang Britta , Aswendt Markus , Wiedermann Dirk , Neumaier Bernd , Drzezga Alexander , Timmermann Lars , Endepols Heike 
Published: May 2019

ABSTRACT
Deep brain stimulation (DBS) in the subthalamic nucleus (STN) has been successfully used for the treatment of advanced Parkinson's disease, although the underlying mechanisms are complex and not well understood. There are conflicting results about the effects of STN-DBS on neuronal activity of the striatum, and its impact on functional striatal connectivity is entirely unknown. We therefore investigated how STN-DBS changes cerebral metabolic activity in general and striatal connectivity in particular. We used ipsilesional STN stimulation in a hemiparkinsonian rat model in combination with [18F]FDOPA-PET, [18F]FDG-PET and metabolic connectivity analysis. STN-DBS reversed ipsilesional hypometabolism and contralesional hypermetabolism in hemiparkinsonian rats by increasing metabolic activity in the ipsilesional ventrolateral striatum and by decreasing it in the contralesional hippocampus and brainstem. Other STN-DBS effects were subject to the magnitude of dopaminergic lesion severity measured with [18F]FDOPA-PET, e.g. activation of the infralimbic cortex was negatively correlated to lesion severity. Connectivity analysis revealed that, in healthy control animals, left and right striatum formed a bilateral functional unit connected by shared cortical afferents, which was less pronounced in hemiparkinsonian rats. The healthy striatum was metabolically connected to the ipsilesional substantia nigra in hemiparkinsonian rats only (OFF condition). STN-DBS (ON condition) established a new functional striatal network, in which interhemispheric striatal connectivity was strengthened, and both the dopamine-depleted and the healthy striatum were functionally connected to the healthy substantia nigra. We conclude that both unilateral dopamine depletion and STN-DBS affect the whole brain and alter complex interhemispheric networks.
Correlation between Body Mass Index and Lipid Profile in patients with Type 2 Diabetes attending a tertiary care hospital in Peshawar
Authors: Hussain Arshad , Ali Iftikhar , Kaleem Waqar Ahmad , Yasmeen Fatima 
Published: May 2019

Objective: To determine the correlation between body mass index (BMI) and lipid profile in patients with Type 2 Diabetes Mellitus (T2DM) attending a tertiary care hospital in Peshawar.
Methods: A total of 305 patients (men, 132; women, 173) with T2DM visiting an Outpatient department in Northwest General Hospital and Research Centre, Peshawar from January 2016 to July 2016 were included in this study. The whole blood and sera were analyzed for Glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TGs), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C).The correlation of BMI with lipid ratios and individual lipid indices were analysed.
Results: Mean of BMI was 29.29±5.23. Dyslipidemia; increased TC, increased LDL-C, increased triglyceride and decreased HDL-C were noted in 40.7%, 54.1%, 69.5% and 41% respectively. The mean difference of LDL-C (p=0.006) was significant between male and female. BMI, TC, TGs, and LDL-C showed no significant correlation where as a significant negative correlation between BMI and HDL-C was observed(r=-0.125, p=0.029, R2=0.016). The mean values of TC, TG, LDL-C, TC/ HDL-C and LDL-C/HDL-C ratios were greater in patients with normal BMI compared to overweight and obese; however, the differences were not significant. HDL-C differed significantly in BMI groups (p=0.040).
Conclusion: A significant negative correlation between BMI and HDL-C was observed, while the correlation between BMI and LDL-C was observed to be insignificant. HDL-C was found significantly higher in patients with normal BMI. These results are important to indicate that there is modest impact of BMI on lipid profile. Therefore, assessment and management for altered blood lipids should not be based on a patient’s body weight or BMI.
doi: https://doi.org/10.12669/pjms.35.3.7
How to cite this:Hussain A, Ali I, Kaleem WA, Yasmeen F. Correlation between Body Mass Index and Lipid Profile in patients with Type 2 Diabetes attending a tertiary care hospital in Peshawar. Pak J Med Sci. 2019;35(3):591-597. doi: https://doi.org/10.12669/pjms.35.3.7
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Dynamic stagnation: reasons for contraceptive non-use in context of fertility stall
Authors: Jadhav Apoorva , Short Fabic Madeleine 
Published: May 2019

Background: While most countries have experienced reductions in the total fertility rate (TFR), there are countries where the fertility transition has not begun and others where the fertility transition has stalled with TFR still well above replacement level. We use these contexts of “fertility stagnation” to explore reasons behind contraceptive non-use among women who desire to delay or avoid a future birth. Specifically, we explore whether women’s reasons for not using contraception are stagnant as the population-level indicator, TFR, suggests or are more dynamic. This nuanced understanding can inform programmatic direction for countries especially in need. Methods: Using Demographic and Health Survey (DHS) data from the two most recent surveys of ten study countries—five countries that have not yet experienced a fertility transition (“pre-transitional”) and five countries that began the fertility transition but stalled (“transitional”)—we explore trends in reasons for non-use. Results: We find that that reasons for non-use are changing. Specifically, in pre-transition study countries, women are increasingly citing attitudes opposing contraception as reasons for non-use. In transition countries, women are increasingly citing reasons related to service quality and method side effects. Perceived low fecundability is increasingly cited among both pre-transition and transition study countries. Geographical access and cost are not prominent frequently cited at either time point. Conclusions: These findings highlight the need for prioritized programmatic attention aimed at: reducing opposition to contraception in pre-transitional countries; improving service quality and addressing issues of side-effects, both experienced and perceived, in transitional countries; and addressing fecundability perceptions in both types of country contexts. We remind policy makers that even in contexts of fertility stagnation, underlying attitudes, norms, and barriers to contraceptive uptake are shifting. Lack of change at the population-level can mask important changes at the individual-level that must be accounted for in program development and implementation.
O que o olho não vê o coração também sente: como cuidar do invisível que nos salta aos olhos
Authors: Prestrelo Eleonôra Torres 
Published: May 2019

Este artigo nasce de inquietações e questionamentos disparados por ecos das falas de alunos da Graduação em Psicologia. Acreditando que as disfunções relacionais se estabelecem pelo abandono da confirmação do outro enquanto ser legitimo em sua alteridade, a autora apresenta um projeto de extensão como espaço de acolhimento e cuidado na universidade, tema que se transformará, posteriormente, em objeto e método de sua pesquisa de doutorado. Em seu trabalho, referencia-se no cuidado que se dá como exigência ontológica dos mundos relacionais, na busca de ampliação de entendimento de nossos modos de existência. Inspirada na noção de cuidado desenvolvida por Annemarie Mol, a autora propõe em sua prática, inclusive a de pesquisa, a mapear, contactar e narrar o que é colocado à margem, os desacertos, os não ditos na elaboração do conhecimento em nossas pesquisas e com eles, talvez, tornar visível as demandas, articulações, afetações presentes no cotidiano acadêmico. Afinada com a diretriz de pesquisa do Laboratório PesquisarCOM (UFF), a autora afirma a pesquisa como uma prática performativa que se faz com o outro e não sobre o outro.
Satisfação de crianças com a vida: as contribuições da família e da escola
Authors: Schütz Fabiane Friedrich , Bortolini Marcela , Sarriera Jorge Castellá 
Published: May 2019

O objetivo do estudo foi investigar a contribuição da satisfação com a família e com a escola para a predição da satisfação com a vida. Participaram 2105 crianças, com idades entre 10 e 12 anos matriculadas em escolas públicas e particulares do Rio Grande do Sul. Os instrumentos utilizados foram: âmbito satisfação com a escola do General Domain Satisfaction Index, cinco itens relativos à satisfação com aspectos dos relacionamentos familiares e a escala de item único Overal Life Satisfaction. Foram realizadas análises de variância por idade e sexo e análise de regressão múltipla. Os resultados indicam que existem diferenças estatisticamente significativas por idade e sexo. A análise de regressão múltipla verificou que os itens que mais predisseram a satisfação com a vida foram relativos a serem ouvidas pelos seus pais (β=0,158; p<0,01), estarem satisfeitas com a experiência na escola (β=0,156; p<0,01) e com os colegas (β=0,124; p<0,01). Ressalta-se que a satisfação com a família e com a escola explicam 21,8% da variância da satisfação com a vida. Destaca-se a importância do estímulo ao diálogo entre família e escola para promover o bem-estar da criança.
Universidade e mercado de trabalho: a trajetória social dos alunos cotistas egressos da Faculdade de Serviço Social da Uerj | University and the labor market: the social trajectory of quota graduate students from the College of Social Work at the State University of Rio de Janeiro
Authors: Barros Clarissa Fernandes do Rêgo 
Published: May 2019

Este artigo tem como objetivo apresentar os resultados da pesquisa qualitativa realizada no doutorado, relacionando educação, política de ação afirmativa na universidade e inserção no mercado de trabalho com 11 alunos cotistas egressos da Faculdade de Serviço Social da Uerj. Os dados apresentados resultam da análise da trajetória social dos estudantes cotistas ao longo da formação na Educação Básica, do ingresso e conclusão na universidade e da inserção no mercado de trabalho. Assim, buscou-se identificar as particularidades, dificuldades, conquistas e possíveis mudanças socioeconômicas alcançadas a partir das políticas de ação afirmativa, tendo como base os princípios normativos de igualdade substancial, justiça social e de eventual mobilidade social, derivadas da profissionalização e do alcance de melhores colocações no mercado de trabalho para este grupo étnico-social específico beneficiado pelas cotas na Uerj.Palavras-Chave: educação; trabalho; política de ação afirmativa; ensino superior. Abstract – This article aims to present the results of the qualitative research carried out in the doctorate’s research connecting education, affirmative action policy in the university, and the insertion in the job market with 11 students from the College of Social Work at the State University of Rio de Janeiro (Uerj). The data presented is based on the analysis of the social trajectory of the quota students along their formation in basic education, access to the university, graduation, and insertion in the labor market. In this way, it is sought to identify the peculiarities, difficulties, achievements, and possible socioeconomic changes achieved from the affirmative action policies, based on the normative principles of substantial equality, social justice, and possible social mobility, derived from the professionalization and the reach of better job market placements for this specific social ethnic group benefited by the quotas at Uerj.Keywords: education; labor; affirmative action policy; higher education.
Coretractable modules relative to a submodule
Authors: HAMZEKOLAEE Ali Reza Moniri , TALEBİ Yahya 
Published: May 2019

Let $R$ be a ring and $M$ a right $R$-module. Let $N$ be a proper submodule
of $M$. We say that $M$ is $N$-coretractable (or $M$ is coretractable relative to $N$)
provided that, for every proper submodule $K$ of $M$ containing $N$, there is
a nonzero homomorphism $f:M/K\rightarrow M$. We present some conditions
that a module $M$ is coretractable if and only if $M$ is coretractable relative to a submodule $N$.	We also provide some examples to illustrate special cases.
The Discrete Steklov–Poincaré Operator Using Algebraic Dual Polynomials
Authors: Zhang Yi , Jain Varun , Palha Artur , Gerritsma Marc 
Published: May 2019

Abstract
In this paper, we will use algebraic dual polynomials to set up a discrete Steklov–Poincaré operator for the mixed formulation of the Poisson problem. The method will be applied in curvilinear coordinates and to a test problem which contains a singularity. Exponential convergence of the trace variable in

H

1
/
2

{H^{1/2}}

-norm will be shown.
Cuspidal ℓ-modular representations of p-adic classical groups
Authors: Kurinczuk Robert , Stevens Shaun 
Published: May 2019

Abstract
For a classical group over a non-archimedean local
field of odd residual characteristic p, we construct all cuspidal representations over an arbitrary algebraically closed field of characteristic different from p, as representations induced from a cuspidal type. We also give a fundamental step towards the classification of cuspidal representations, identifying when certain cuspidal types induce to equivalent representations; this result is new even in the case of complex representations. Finally, we prove that the representations induced from more general types are quasi-projective, a crucial tool for extending the results here to arbitrary irreducible representations.
On sup-norm bounds part II: GL(2) Eisenstein series
Authors: Assing Edgar 
Published: May 2019

Abstract
In this paper we consider the sup-norm problem in the context of analytic Eisenstein series for

GL
2

{\mathrm{GL}_{2}}

over number fields. We prove a hybrid bound which is sharper than the corresponding bound for Maaß forms.
Our results generalize those of Huang and Xu where the case of Eisenstein series of square-free levels over the base field

ℚ

{\operatorname{\mathbb{Q}}}

had been considered.
On classification of typical representations for GL3(F)
Authors: Nadimpalli Santosh 
Published: May 2019

Abstract
Let F be any non-Archimedean local field with residue field of
cardinality

q
F

{q_{F}}

. In this article, we obtain a classification of
typical representations for the Bernstein components associated to
the inertial classes of the form

[

GL
n

⁡

(
F
)

×

F
×

,

σ
⊗
χ

]

{[\operatorname{GL}_{n}(F)\times F^{\times},\sigma\otimes\chi]}

with

q
F

>
2

{q_{F}>2}

, and for
the principal series components with

q
F

>
3

{q_{F}>3}

. With this we complete
the classification of typical representations for

GL
3

⁡

(
F
)

{\operatorname{GL}_{3}(F)}

, for

q
F

>
2

{q_{F}>2}

.
Effect of Aging on Characteristics of Bitumen Modified with Waste Lime Sludge
Authors: Kanoungo Abhishek , Kanwar Varinder S. , Shukla Sanjay Kumar 
Published: May 2019

Abstract
The design of pavement must be carried out to make it capable of evenly transferring the wheel load to the subgrade soil without exceeding its bearing capacity. However, failure occurs before the design life because of structural defects shown by pavements, such as low skid resistance, fatigue, and rutting. Because low-temperature cracking is more predominant in cold-temperature regions, this aspect of failure is considered within the future scope of study. To address this concern, waste lime sludge was added to improve the properties of bitumen in the present research work. In order to examine the effect of aging, the rolling thin-film oven test was conducted to replicate the short-term aging process, and pressure aging vessel test was used to resemble long-term aging. The viscosity test, softening point test, and penetration test were carried out to assess the physical properties, whereas the dynamic shear rheometer test was conducted to investigate the rheological properties of aged and unaged bitumen binders. It is observed that sludge acts as an aging inhibitor. The complex modulus was enhanced as a result of addition of sludge up to 20 %, which also lowered the values of phase angle, depicting high resistance to permanent deformation. The rutting and fatigue resistances of the binder improved, and soft grade bitumen was converted to hard grade bitumen.