bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of inversion of distorted magnetotelluric sounding curves (numerical experiment)
Authors: Plotkin V.V. 
Published: March 2018

Abstract
The paper presents the results of a joint inversion of magnetotelluric sounding (MTS) curves taken at several stations without preliminary selection and normalization and distorted by the presence of lateral electrical-conductivity inhomogeneities in the medium. In the calculations, we used synthetic MTS data for a three-dimensional model. Preparation and interpretation of data are carried out by the Trefftz method using a numerical model of the field and MTS curve distortions. To solve the inverse problem and optimize the subsurface model, we used a nonlinear least-squares method and an iterative process with calculation of the sensitivity matrix and its singular decomposition. The target functional is determined by the discrepancies between the model and synthetic experimental apparent-resistivity curves corresponding to the elements of the impedance tensors on the lateral diagonal. The reliability of the reconstructed subsurface model is characterized by the dispersion of the deviations of its parameters from the parameters of the known model used for the preparation of synthetic experimental data. The joint consideration of distorted apparent-resistivity curves at several stations increases the reliability of interpretation results. The obtained solution to the inverse problem is approximate and can be used as a starting model for more complex algorithms and programs.
The probability of unusually large components in the near-critical Erdős–Rényi graph
Authors: Roberts Matthew I. 
Published: March 2018

Abstract

The largest components of the critical Erdős–Rényi graph, G(n, p) with p = 1 / n, have size of order n
2/3 with high probability. We give detailed asymptotics for the probability that there is an unusually large component, i.e. of size an
2/3 for large a. Our results, which extend the work of Pittel (2001), allow a to depend upon n and also hold for a range of values of p around 1 / n. We also provide asymptotics for the distribution of the size of the component containing a particular vertex.
An optimal consumption and investment problem with partial information
Authors: Hata Hiroaki , Sheu Shuenn-Jyi 
Published: March 2018

AbstractWe consider a finite-time optimal consumption problem where an investor wants to maximize the expected hyperbolic absolute risk aversion utility of consumption and terminal wealth. We treat a stochastic factor model in which the mean returns of risky assets depend linearly on underlying economic factors formulated as the solutions of linear stochastic differential equations. We discuss the partial information case in which the investor cannot observe the factor process and uses only past information of risky assets. Then our problem is formulated as a stochastic control problem with partial information. We derive the Hamilton–Jacobi–Bellman equation. We solve this equation to obtain an explicit form of the value function and the optimal strategy for this problem. Moreover, we also introduce the results obtained by the martingale method.
NEW HORIZONS IN BRAZILIAN CONTEMPORARY MUSIC: GRUPO NOVO HORIZONTE DE SÃO PAULO, 1988–99
Authors: Dromey Christopher 
Published: March 2018

AbstractBrazil's foremost ensemble of the late twentieth century, Grupo Novo Horizonte de São Paulo, transformed Brazilian contemporary music by cultivating a new mixed-chamber repertory and giving sustained support to a generation of emerging composers. That this cosmopolitan group took, then outgrew, the Pierrot ensemble as its cornerstone signals the medium it forged: a localized, evolving spectacle with a richly internationalist heritage. This article offers a panoramic view of the musical, intercultural and historical contexts that underpin Grupo Novo Horizonte's practices and legacy. Analysing landmark works by Sílvio Ferraz, Harry Crowl and others allows us to draw further connections between the group, the Brazilianness of late twentieth-century compositional aesthetic, and the realities of contemporary classical music-making in Brazil.
Practitioners’ experiences of working collaboratively with interpreters to provide CBT and guided self-help (GSH) in IAPT; a thematic analysis
Authors: Tutani Lumka , Eldred Clare , Sykes Catherine 
Published: March 2018

AbstractWithin IAPT (Improving Access to Psychological Therapies), cognitive behavioural therapy (CBT) is offered to all clients regardless of gender, religion, culture and language. Hence, the demand for working with interpreters to facilitate communication during therapy in IAPT has increased. This study explored the experience of therapists working with interpreters to facilitate communication in psychological therapies with clients with mild to moderate anxiety and depression including those with co-morbid physical health problems. Thirteen participants, including six CBT therapists and seven Psychological Wellbeing Practitioners (PWPs) working in an NHS IAPT service, were interviewed. A qualitative approach, using semi-structured interviews and thematic analysis (Braun and Clarke, 2006), was implemented. The following four major themes were identified from the participants’ accounts: negotiating a three-way communication, difficulties in expressing empathy, a lack of shared understanding and working creatively with interpreters. During this collaborative working new understandings of engaging emerged leading participants to view this work as possible.
A suite of global, cross-scale topographic variables for environmental and biodiversity modeling
Authors: Amatulli Giuseppe , Domisch Sami , Tuanmu Mao-Ning , Parmentier Benoit , Ranipeta Ajay , Malczyk Jeremy , Jetz Walter 
Published: March 2018

AbstractTopographic variation underpins a myriad of patterns and processes in hydrology, climatology, geography and ecology and is key to understanding the variation of life on the planet. A fully standardized and global multivariate product of different terrain features has the potential to support many large-scale research applications, however to date, such datasets are unavailable. Here we used the digital elevation model products of global 250 m GMTED2010 and near-global 90 m SRTM4.1dev to derive a suite of topographic variables: elevation, slope, aspect, eastness, northness, roughness, terrain roughness index, topographic position index, vector ruggedness measure, profile/tangential curvature, first/second order partial derivative, and 10 geomorphological landform classes. We aggregated each variable to 1, 5, 10, 50 and 100 km spatial grains using several aggregation approaches. While a cross-correlation underlines the high similarity of many variables, a more detailed view in four mountain regions reveals local differences, as well as scale variations in the aggregated variables at different spatial grains. All newly-developed variables are available for download at Data Citation 1 and for download and visualization at http://www.earthenv.org/topography.
U-Index, a dataset and an impact metric for informatics tools and databases
Authors: Callahan Alison , Winnenburg Rainer , Shah Nigam H 
Published: March 2018

AbstractMeasuring the usage of informatics resources such as software tools and databases is essential to quantifying their impact, value and return on investment. We have developed a publicly available dataset of informatics resource publications and their citation network, along with an associated metric (u-Index) to measure informatics resources’ impact over time. Our dataset differentiates the context in which citations occur to distinguish between ‘awareness’ and ‘usage’, and uses a citing universe of open access publications to derive citation counts for quantifying impact. Resources with a high ratio of usage citations to awareness citations are likely to be widely used by others and have a high u-Index score. We have pre-calculated the u-Index for nearly 100,000 informatics resources. We demonstrate how the u-Index can be used to track informatics resource impact over time. The method of calculating the u-Index metric, the pre-computed u-Index values, and the dataset we compiled to calculate the u-Index are publicly available.
Analysis on the magnetic shunt structure of large power transformer
Authors: Yang Huina , Zhang Yongshuai 
Published: March 2018

Installing magnetic shunts on the surfaces of tank and clamps of power transformer is able to reduce the eddy current losses and decrease the temperature rise effectively. Here, the three‐dimensional transient finite element method and the magnetic thermal coupling method are used to calculate and analyse the effect of magnetic shunts with different structures. The non‐linear magnetic property of both the transformer structural parts and the magnetic shunts are considered in the analysis. The lamination structure of the shunt is also considered, which is simulated by a thick plate with anisotropic magnetic property. A 334 MVA single‐phase transformer is taken as an example in the analysis. The optimisation shunt structure is obtained. By comparing the L‐shaped, the inverted L‐shaped, and the U‐shaped magnetic shunts for the clamps, it is proved that the U‐shaped shunt is more effective in reducing the eddy current loss and temperature rise.
Field spheroid-dominated galaxies in a Λ-CDM Universe
Authors: Rosito M. S. , Pedrosa S. E. , Tissera P. B. , Avila-Reese V. , Lacerna I. , Bignone L. A. , Ibarra-Medel H. J. , Varela S. 
Published: March 2018

Context. Understanding the formation and evolution of early-type, spheroid-dominated galaxies is an open question within the context of the hierarchical clustering scenario, particularly in low-density environments.
Aims. Our goal is to study the main structural, dynamical, and stellar population properties and assembly histories of field spheroid-dominated galaxies formed in a Λ-cold dark matter (Λ-CDM) scenario to assess to what extent they are consistent with observations.
Methods. We selected spheroid-dominated systems from a Λ-CDM simulation that includes star formation (SF), chemical evolution, and supernova feedback. The sample is made up of 18 field systems with MStar ≲ 6 × 1010M⊙ that are dominated by the spheroid component. For this sample we estimated the fundamental relations of ellipticals and compared them with current observations.
Results. The simulated spheroid galaxies have sizes that are in good agreement with observations. The bulges follow a Sersic law with Sersic indexes that correlate with the bulge-to-total mass ratios. The structural-dynamical properties of the simulated galaxies are consistent with observed Faber–Jackson, fundamental plane, and Tully–Fisher relations. However, the simulated galaxies are bluer and with higher star formation rates (SFRs) than the observed isolated early-type galaxies. The archaeological mass growth histories show a slightly delayed formation and more prominent inside-out growth mode than observational inferences based on the fossil record method.
Conclusions. The main structural and dynamical properties of the simulated spheroid-dominated galaxies are consistent with observations. This is remarkable since our simulation has not been calibrated to match them. However, the simulated galaxies are blue and star-forming, and with later stellar mass growth histories compared to observational inferences. This is mainly due to the persistence of extended discs in the simulations. The need for more efficient quenching mechanisms able to avoid further disc growth and SF is required in order to reproduce current observational trends.
Factor XII-dependent Contact Activation on Endothelial Cells and Binding Proteins gC1qR and Cytokeratin 1
Authors: Joseph Kusumam , Shibayama Yoji , Ghebrehiwet Berhane , Kaplan Allen 
Published: March 2018

SummaryAlthough proteins of the kinin-forming pathway are bound along the surface of endothelial cells, the mechanism of activation of this proteolytic cascade is unclear. Endothelial cell surface proteins, gC1qR and cytokeratin 1, are capable of binding Factor XII and high molecular weight kininogen (HK) in a zinc-dependent reaction thus we considered the possibility that these proteins might catalyze initiation of the cascade. Incubation of Factor XII, prekallikrein, and HK with gC1qR or cytokeratin 1 leads to a zinc-dependent and Factor XII-dependent conversion of prekallikrein to kallikrein. We also demonstrate that normal plasma is capable of activating upon interaction with the cells whereas plasma deficient in Factor XII, prekallikrein and HK do not activate. Normal plasma activation was inhibitable by antibody to gC1qR and cytokeratin 1. Thus, gC1qR and cytokeratin 1, represent potential initiating surfaces for activation of the plasma kinin-forming cascade and may do so as a result of their expression along cell surfaces.
Expression of Translation Initiation Factors eIF-4E and eIF-2α and a Potential Physiologic Role of Continuous Protein Synthesis in Human Platelets
Authors: Han Anping , Lu Linrong , Pihan German , Woda Bruce , Chen Jane-Jane , Szymanski Irma , Rosenwald Igor , Pechet Liberto 
Published: March 2018

SummaryIt is generally believed that platelets do not have a functionally significant protein synthetic machinery. However, our analysis demonstrated that normal bone marrow megakaryocytes express high levels of translation initiation factors eIF-4E and eIF-2α and the expression of these protein synthesis initiation factors is continued in platelets (as determined by immunohistochemistry and Western blot analysis). Both eIF-4E and eIF-2α are key regulators of protein synthesis. The eIF-4E is a rate-limiting part of a multisubunit complex, eIF-4F, that binds to the 5’ cap structure present in virtually all eukaryotic mRNAs, and carries out transfer of mRNAs to ribosomes for translation. Translation initiation factor eIF-2α is also a rate-limiting protein which associates with two other proteins to form an eIF-2 initiation factor complex responsible for the transfer of initiator methionyl-tRNA to the 40S ribosomal subunit. We confirm that expression of eIF-4E and eIF-2α is biologically relevant in that platelets continue protein synthesis, albeit at a 16 times lower rate than WBC (as determined by 35S-labeled amino acid incorporation, SDS-PAGE and scintillation counting). Finally, we determined that protein synthesis inhibitors (puromycin and emetine) attenuate the platelet aggregation response to a combination of ADP and epinephrine, but potentiate the response to collagen. Our data are consistent with the existence of different signal transducing pathways mediating the response to ADP/epinephrine and collagen. We suggest that the ADP/epinephrine response is positively affected by continuously synthesized proteins, while the response to collagen is modulated by continuously produced inhibitory proteins. Taken together, our results suggest that continuous protein synthesis is important for platelet function and its role in platelet physiology and pathophysiology deserves further study.
Exogenous Inhibitors of Platelet Aggregation from Animal Sources
Authors: Chow Geraldine , Kini R. Manjunatha 
Published: March 2018

SummaryThis updated inventory includes all inhibitors of platelet aggregation from animal sources until mid-1999. They are proteins or glycoproteins with Mr from 5000 to tens of thousands, and inhibit platelet aggregation by different mechanisms. Most lack enzymatic activity, but some exhibit enzymatic activities, such as phospholipase A2 (PLA2), proteinase and nucleotidase.
The Utility of activated Partial Thromboplastin Time (aPTT) Clot Waveform Analysis in the Investigation of Hemophilia A Patients with very Low Levels of Factor VIII Activity (FVIII:C)
Authors: Matsumoto Tomoko , Fukuda Kazuyoshi , Kubota Youko , Tanaka Ichiro , Nishiya Katumi , Giles Alan , Yoshioka Akira , Shima Midori 
Published: March 2018

SummaryThe lower detection limit of the conventional one-stage aPTT based clotting assay for determining FVIII:C levels is generally 1.0-2.0 IU/dl. Consequently, it has been impossible to study the clinical significance of levels of FVIII:C less than 1.0 IU/dl. Using a photo-optical automated coagulation analyzer, the Organon Teknika MDA II®, we have performed qualitative and quantitative aPTT waveform analysis and measured FVIII:C levels by automated one-stage aPTT clotting assay in 36 severely affected Hemophilia A patients. Qualitative waveform analysis showed clear evidence of individual differences in the waveform profile suggesting differing coagulant activity from patient to patient. The FVIII:C level was less than 0.2 IU/dl in 23 cases and levels of FVIII:C between 0.2 and 1.0 IU/dl could be discriminated in 13 patients. The FVIII:C level in these patients was closely correlated with the minimum value of the second derivative of the aPTT waveform (Min2). This is a measure of the acceleration of change in optical transmission at the initiation of coagulation. Furthermore, the correlation of the aPTT (time and Min2) and the FVIII:C level, determined by a one-stage clotting assay on the same system, was high in plasmas with a range of levels of FVIII:C artificially prepared by the addition of various concentrations of rFVIII:C to FVIII deficient plasma. These data suggest that it is possible to segregate different levels of clotting activity in patients previously assigned to a single grouping, i.e. less than 1.0 IU/dl, by conventional one-stage assay. Thus clot waveform analysis may be useful for the investigation of the clinical phenotype of individual patients and their response to therapy.
A Comparative Multi-laboratory Assessment of Three Factor VIII/von Willebrand Factor Concentrates
Authors: Bukuya Melinda , Martinelli Teresa , Tzouroutis Joanne , Duncan Elizabeth , Welldon Katie , Collecutt Margaret , Aumann Heather , Thom Jim , Gilmore Grace , Favaloro Emmanuel 
Published: March 2018

SummaryFive expert laboratories have participated in a cross-laboratory study to co-evaluate and compare three commercial Factor VIII/von Willebrand factor (VWF) concentrates. A total of nine factor concentrate lots were evaluated, comprising AHF (High Purity) (AHF HP; X3), Biostate® (X3) and Humate/Haemate (X3). All laboratories blind tested for FVIII:C, VWF:Ag and VWF:CB, four tested for VWF:RCo, and one performed VWF:Multimers. The study yielded inter-laboratory CVs for VWF:Ag and FVIII:C around 10–15%, and for VWF:CB and VWF:RCo around 20%, significantly lower than those of previous multi-laboratory surveys. All three lots of AHF HP contained in the vicinity of 25 U/ml FVIII:C, around 60–75 U/ml of VWF:Ag, but only 30–45 U/ml of VWF:CB and 40–50 U/ml of VWF:RCo (thus, CB/Ag ratio around 0.5–0.6 and RCo/Ag ratio around 0.6–0.7). Study determined that FVIII:C and VWF:RCo levels were similar to manufacturer assigned levels. Some loss of the high molecular weight (HMW) multimers was observed, together with an intense low molecular weight (LMW) VWF band consistent with some reduction or proteolysis of HMW VWF. All three lots of Humate/Haemate contained in the vicinity of 23–32 U/ml of FVIII:C, 70–105 U/ml of VWF:Ag, 50–90 U/ml of VWF:CB and VWF:RCo (i. e. CB/Ag ratio around 0.6–0.9 and RCo/Ag ratio around 0.6–1.1). Study-determined FVIII:C and VWF:RCo levels were similar to manufacturer-assigned levels. The LMW multimer band seen with AHF HP was also observed with Humate/Haemate. All three lots of Biostate contained in the vicinity of 40–55 U/ml of FVIII:C, 105–170 U/ml of VWF:Ag, 90–150 U/ml of VWF:CB, and 90–135 U/ml of VWF:RCo (i. e. CB/Ag and RCo/Ag ratios around 0.7–1.0). Study-determined FVIII:C levels were similar to manufacturer-assigned levels. The LMW multimer band seen with AHF HP was not observed with Biostate. The defined pattern of increasing CB/ Ag from AHF HP to Humate/Haemate and Biostate was consistently observed in study data from each of the five laboratories. In conclusion, study findings indicate some differences in the retention of functional/ HMW VWF between factor concentrates, and this is expected to have significant implications in terms of clinical efficacy for therapy in VWD.
Local proCPU (TAFI) Activation during Thrombolytic Treatment in a Dog Model of Coronary Artery Thrombosis can be Inhibited with a Direct, Small Molecule Thrombin Inhibitor (Melagatran)
Authors: Björkman J. A. , Abrahamsson T. , Nerme V. , Schatteman K. , Leurs J. , Scharpé S. , Hendriks D. , Mattsson C. 
Published: March 2018

SummaryTo test the hypothesis that the direct thrombin inhibitor, melagatran is able to inhibit local pro-carboxypeptidase U (proCPU) activation that occurs during thrombolytic treatment, t-PA alone, or in combination with melagatran, was given to dogs with a coronary artery thrombosis. Blood samples from the great cardiac vein and aorta were collected at baseline, during thrombus formation, throughout the t-PA±melagatran infusion and during the patency period, for analysis of CPU activity using a novel assay. A higher CPU activity in venous compared to arterial blood (V-A difference) indicates CPU activation in coronary vessels.Efficacy was assessed by determination of time to lysis, duration of patency and blood flow during patency. Dogs (n = 26) were randomized to receive either 1) t-PA, 1 mg/kg as an intravenous 20-min infusion; 2) t-PA as in group 1,+ melagatran bolus, 0.3 mg/kg, followed by a 3-h infusion (0.15 mg/kg per h); 3) sham-operated but no coronary thrombus, and administered t-PA as for Group 1. All groups had similar baseline characteristics. Significant increases in CPU activity were observed in Groups 1 and 2 during thrombus formation, with V-A differences of 5.5 and 4.5 U/L, respectively. No significant V-A difference was observed in the sham-operated group. CPU activity increased in Group 1 during the t-PA infusion (V-A difference 15.9 U/L), whereas the V-A difference in Group 2 decreased to 2.6 U/L following melagatran treatment. These results demonstrate that melagatran attenuates generation of CPU in the coronary circulation. The mechanism is probably indirect, via inhibition of thrombin-mediated activation of proCPU.