bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production, Characterization, and Application of Hydrophobin‐Based IR780 Nanoparticles for Targeted Photothermal Cancer Therapy and Advanced Near‐Infrared Imaging
Authors: Yang Jiyuan , Wang Wenjun , Huang Siyuan , Guo Dingyi , Yu Long , Qiao Wanjin , Zhang Xu , Han Zhiqiang , Song Bo , Xu Xiaoting , Wu Zhenzhou , Dordick Jonathan S. , Zhang Fuming , Xu Haijin , Qiao Mingqiang 
Published: November 2024

AbstractAs a promising approach for breast cancer treatment, photothermal therapy (PTT) features high spatial selectivity, noninvasiveness, and minimal drug resistance. IR780 (a near‐infrared fluorescent dye) serves as an effective photosensitizer in PTT cancer therapy. However, the clinical application of IR780 in PTT has been hindered by its poor water solubility and unstable photostability. In this study, a genetically engineered dual‐functional fusion protein tLyP‐1‐MGF6 is successfully constructed and expressed, which presents a novel use of hydrophobin MGF6 for its amphiphilicity combined with the tumor‐penetrating peptide tLyP‐1 to create an innovative carrier for IR780. These results show this fusion protein serving as a biodegradable and biocompatible carrier, significantly improves the water solubility of IR780 when formulated into nanoparticles. These studies demonstrate that the IR780@tLyP‐1‐MGF6 nanoparticles significantly enhance tumor targeting and photothermal therapeutic efficacy in comparison with control in vitro and in vivo. These advancements highlight the potential of the unique combination hydrophobin‐based IR780 delivery system as a multifunctional nanoplatform for integrated imaging and targeted photothermal treatment of breast cancer.
Fe/Cu Bimetallic Nanozyme Co‐Assembled with 177Lu and Tanshinone for Quadruple‐Synergistic Tumor‐Specific Therapy
Authors: Zhu Xianyu , Zheng Lingling , Zhao Pengfei , Gao Lingli , Wang Liang , Liu Jun , Yang Xu , Wei Hanrui , Zhang Mingyu , Yan Liang , Lv Han , Gong Jianhua , Yang Ji gang , Wang Zhenchang 
Published: November 2024

AbstractThe co‐loading of radionuclides and small‐molecule chemotherapeutic drugs as nanotheranostic platforms using nanozymes holds tremendous potential for imaging‐guided synergistic therapy. This study presents such nanotheranostic platform (177Lu‐MFeCu@Tan) via co‐assembling 177Lu radionuclide and tanshinone (Tan) into Fe/Cu dual‐metal nanozyme (MFeCu). This platform simultaneously enables single‐photon emission computed tomography (SPECT) imaging and a quadruple‐synergistic tumor therapy approach, including internal radioisotope therapy (RIT), catalysis therapy, chemotherapy, and MFeCu‐mediated ferroptosis and cuproptosis therapy. In this platform, the MFeCu can catalyze excessive intracellular hydrogen peroxide (H2O2) to generate radical oxygen species (ROS) and deplete glutathione (GSH). The excess of H2O2 and GSH are main factors for radioresistance and chemoresistance, reducing them can enhance chemotherapy and RIT. The generated ROS and depleted GSH further induce mitochondrial dysfunction and promote the aggregation of lipoylated dihydrolipoamide S‐acetyltransferase and lipid peroxidation, causing the enhance of ferroptosis and cuproptosis. The in vitro and in vivo results demonstrate that this quadruple‐synergistic approach shows significant therapeutic efficacy to complete tumor eradication and reduced recurrence in vivo. In conclusion, this work presents a promising strategy for designing SPECT imaging‐guided quadruple‐synergistic therapy and highlights the feasibility of developing a self‐assembled radionuclide and small molecule chemotherapy drugs nanotherapeutic platform for combined treatment of cancer.
A Polymeric Hole Transporter with Dual‐Interfacial Interactions Enables 25%‐Efficiency Blade‐Coated Perovskite Solar Cells
Authors: Wang Feifei , Liu Tianxiao , Liu Yangyang , Zhou Yuhan , Dong Xiaorui , Zhang Yaoyao , Shi Xiaoyu , Dou Yunjie , Ren Zhijun , Wang Lingyuan , Zhao Yu , Luo Siwei , Hu Xiaodong , Peng Xiaoxiao , Bao Chunxiong , Wang Wei , Wang Jingyang , Hu Wenbing , Chen Shangshang 
Published: November 2024

AbstractSelf‐assembly monolayer (SAM) hole transporters, consisting of anchoring, spacer, and terminal groups, have played a significant role in the development of inverted perovskite solar cells (PSCs). However, the weak interaction between perovskite and hydrophobic terminal group of SAMs limits surface wettability and interface stability. To address this issue, two novel hole transporters (named DBPP and Poly‐DBPP) with centrosymmetric biphosphonic acid groups are developed. Unlike conventional SAM hole transporters, the biphosphonic acid groups in DBPP and Poly‐DBPP can anchor to the underlying conductive substrate and interact with the perovskite layer simultaneously, improving surface wettability and suppressing interface recombination. Furthermore, compared to the small‐molecular DBPP, Poly‐DBPP exhibits higher conductance and excellent uniformity. This translates to a remarkable power conversion efficiency of 25.1% for blade‐coated PSCs and 22.0% for large‐area modules, respectively. Additionally, the PSCs based on Poly‐DBPP demonstrate impressive operational stability, retaining 92% of their initial PCE after 1,600 h of light soaking. This work presents a promising strategy for designing multifunctional hole transporters, paving the way for highly efficient and stable PSCs.
Low‐Spin Fe3+ Evoked by Multiple Defects with Optimal Intermediate Adsorption Attaining Unparalleled Performance in Water Oxidation
Authors: Wang Yihao , Li Shanqing , Hou Xu , Cui Tingting , Zhuang Zechao , Zhao Yunhe , Wang Haozhi , Wei Wei , Xu Ming , Fu Qiang , Chen Chunxia , Wang Dingsheng 
Published: November 2024

AbstractElectrocatalytic water splitting is long constrained by the sluggish kinetics of anodic oxygen evolution reaction (OER), and rational spin‐state manipulation holds great promise to break through this bottleneck. Low‐spin Fe3+ (LS, t2g5eg0) species are identified as highly active sites for OER in theory, whereas it is still a formidable challenge to construct experimentally. Herein, a new strategy is demonstrated for the effective construction of LS Fe3+ in NiFe‐layered double hydroxide (NiFe‐LDH) by introducing multiple defects, which induce coordination unsaturation over Fe sites and thus enlarge their d orbital splitting energy. The as‐obtained catalyst exhibits extraordinary OER performance with an ultra‐low overpotential of 244 mV at the industrially required current density of 500 mA cm−2, which is 110 mV lower than that of the conventional NiFe‐LDH with high‐spin Fe3+ (HS, t2g3eg2) and superior to most previously reported NiFe‐based catalysts. Comprehensive experimental and theoretical studies reveal that LS Fe3+ configuration effectively reduces the adsorption strength of the O* intermediate compared with that of the HS case, thereby altering the rate‐determining step from (O* → OOH*) to (OH* → O*) of OER and lowering its reaction energy barrier. This work paves a new avenue for developing efficient spin‐dependent electrocatalysts for OER and beyond.
Gradient Distribution of Zincophilic Sites for Stable Aqueous Zinc‐Based Flow Batteries with High Capacity
Authors: Wei Zhiquan , Qu Guangmeng , Huang Zhaodong , Wang Yiqiao , Li Dedi , Yang Xinru , Zhang Shaoce , Chen Ao , Wang Yanbo , Hong Hu , Li Qing , Zhi Chunyi 
Published: November 2024

AbstractCurrent collectors, as reaction sites, play a crucial role in influencing various electrochemical performances in emerging cost‐effective zinc‐based flow batteries (Zn‐based FBs). 3D carbon felts (CF) are commonly used but lack effectiveness in improving Zn metal plating/stripping. Here, a current collector with gravity‐induced gradient copper nanoparticles (CF‐G‐Cu NPs) is developed, integrating gradient conductivity and zincophilicity to regulate Zn deposition and suppress side reactions. The CF‐G‐Cu NPs electrode modulates Zn nucleation and growth via the zincophilic Cu/CuZn5 alloy has been confirmed by density functional theory (DFT) calculations. Finite element simulation demonstrates the gradient internal structure effectively optimizes the local electric/current field distribution to regulate the Zn2+ flux, improving bottom‐up plating behavior for Zn metal and mitigating top‐surface dendrite growth. As a result, Zn‐based asymmetrical FBs with CF‐G‐Cu NPs electrodes achieve an areal capacity of 30 mAh cm−2 over 640 h with Coulombic efficiency of 99.5% at 40 mA cm−2. The integrated Zn‐Iodide FBs exhibit a competitive long‐term lifespan of 2910 h (5800 cycles) with low energy efficiency decay of 0.062% per cycle and high cumulative capacity of 112800 mAh cm−2 at a high current density of 100 mA cm−2. This gradient distribution strategy offers a simple mode for developing Zn‐based FB systems.
Asymmetric and Ultrasensitive Structural Color Response in Nanochain‐Embedded Photonic Composites
Authors: Lyu Quanqian , Lin Zhuoyuan , Wang Peng , Zhang Lianbin , Zhu Jintao 
Published: November 2024

AbstractMechanochromic photonic crystals, capable of altering structural colors in response to external forces, are emerging intelligent materials in various fields, such as visual sensors and anti‐counterfeiting technologies. However, conventional mechanical responses of photonic crystals mainly rely on stretching or compression, resulting in symmetric and limited mechanochromic effects due to restricted changes in lattice spacing, particularly limiting the recognition of the direction of force. Here, asymmetric and ultrasensitive structural color responses are reported in colloidal photonic composites featuring embedded one‐dimensional (1D) photonic nanochains of colloidal particles based on shear‐induced lattice orientation change. It is shown that shearing deformation tilts the photonic nanochains within the polymer matrix, leading to a remarkable and asymmetric color shift depending on shear force and observing directions. The asymmetric response encourages to develop ultrasensitive twist sensors capable of detecting subtle twisting movements as low as 0.2° and twist direction. Furthermore, by integrating magnetic and deformation orientation control, dynamic optical anti‐counterfeiting labels capable of displaying highly intricate patterns are devised. This unique shear‐induced color‐shifting mechanism expands the responsiveness of mechanochromic materials, with broad implications in many other areas, including structural health monitoring, soft robotics, and artificial skin.
Modulating RuO2 Electrocatalysis via Introducing Lanthanides for Enhanced Acidic Oxygen Evolution
Authors: Ding Qi , Xie Linfeng , Lin Zijie , Qin Zhuhuang , Li Yunan , Li Qing 
Published: November 2024

AbstractThe low activity of ruthenium dioxide (RuO2) and the rapid dissolution of the ruthenium (Ru) site during acid oxygen evolution reaction (OER) at high current density restricts its application in proton exchange membrane (PEM) electrolyzers. In this work, a series of rare‐earth (RE) elements doped RuO2 nanorods is developed as high‐performance OER electrocatalysts. X‐ray absorption spectroscopy suggests that RE doping regulates the local coordination environment around Ru sites, lowers the valance of Ru, and shortens the Ru─O─Ru(M) bond length, which enhances structural stability. Among the RE‐RuO2 samples, Sm‐RuO2 exhibits remarkable performance with a low overpotential of 283 mV to reach 100 mA cm−2 and maintained stability for over 140 h at 10 mA cm−2. Moreover, the PEM electrolyzer using Sm‐RuO2 as the anode can be stably operated at 500 mA cm−2 for 15 h. Electrochemical analysis, X‐ray photoelectron spectroscopy, and in situ Raman spectroscopy show that Sm doping lowers the d‐band center, reduces the adsorption energy of O intermediates to enhance the OER activity, and restrains excessive oxidation of Ru sites while stabilizing lattice oxygen during the OER process, thereby enhancing OER stability. This work offers valuable insights into improving the stability of metal oxide catalysts in acidic electrolytes.
Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration
Authors: Shariati Kaavian , Bedar Meiwand , Huang Kelly X. , Moghadam Shahrzad , Mirzaie Sarah , LaGuardia Jonnby S. , Chen Wei , Kang Youngnam , Ren Xiaoyan , Lee Justine C. 
Published: November 2024

AbstractTissue regeneration involves dynamic dialogue between and among different cells and their surrounding matrices. Bone regeneration is specifically governed by reciprocity between osteoblasts and osteoclasts within the bone microenvironment. Osteoclast‐directed resorption and osteoblast‐directed formation of bone are essential to bone remodeling, and the crosstalk between these cells is vital to curating a sequence of events that culminate in the creation of bone tissue. Among bone biomaterial strategies, many have investigated the use of different material cues to direct the development and activity of osteoblasts. However, less attention has been given to exploring features that similarly target osteoclast formation and activity, with even fewer strategies demonstrating or integrating biomaterial‐directed modulation of osteoblast‐osteoclast coupling. This review aims to describe various biomaterial cues demonstrated to influence osteoclastogenesis and osteoclast function, emphasizing those that enhance a material construct's ability to achieve bone healing and regeneration. Additionally discussed are approaches that influence the communication between osteoclasts and osteoblasts, particularly in a manner that takes advantage of their coupling. Deepening the understanding of how biomaterial cues may dictate osteoclast differentiation, function, and influence on the microenvironment may enable the realization of bone‐replacement interventions with enhanced integrative and regenerative capacities.
Pnictogen Atom Substitution to Modify the Electronic and Magnetic Properties of SiS2${\rm SiS}_{2}$ Monolayer: A DFT Study
Authors: Han Nguyen Thi , Guerrero‐Sanchez J. , Hoat D. M. 
Published: November 2024

AbstractThe density functional theory (DFT) is employed to study the modulation of electronic and magnetic properties of monolayer through doping with pnictogen (P and As) atoms. monolayer is intrinsically non‐magnetic, exhibiting the semiconductor nature with indirect bandgap of 1.39(2.26) eV provided by standard(hybrid) functional. This 2D material is metallized under effects of single Si vacancy, single S vacancy, and pair Si─S vacancies. In the latter case, significant magnetism with a total magnetic moment of 1.55 is produced mainly by S atoms around the vacancy sites. The monolayer metallization takes place also when doping with P and As atoms at Si sublattice, preserving the nonmagnetic nature. Meanwhile, P and As substitution leads to the emergence of magnetism with total magnetic moments of 0.93 and 0.99 , respectively. Herein, magnetic properties are produced mainly by the outermost orbital of pnictogen impurities. Interestingly, the results assert the emergence of the half‐metallicity, which gives evidence of new highly spin‐polarized 2D materials. Further, doping with pair P/P, As/As, and P/As atoms are also considered with different doping configurations. It is found that the nonmagnetic semiconductor nature is preserved upon doping with pair pnictogen atoms, however, the indirect‐to‐direct gap transition is induced. Moreover, the energy gap exhibits large reduction between 51.80% and 77.70%. The findings in this work may suggest the formation of prospective optoelectronic and spintronic 2D materials by doping monolayer with pnictogen atoms.
Manganese‐Based Composite‐Structure Cathode Materials for Sustainable Batteries
Authors: Liu Shiqi , Wang Yulong , Du Haozhe , Li Yuming , Wang Yinzhong , Wang Guoqing , Wang Jian , Liao Qianyong , Guo Xianwei , Yu Haijun 
Published: November 2024

AbstractManganese‐based cathode materials have garnered extensive interest because of their high capacity, superior energy density, and tunable crystal structures. Despite their cost‐effectiveness, challenges like Mn dissolution and gas evolution originating from the irreversible structural degradation pose risks to stability and prolonged electrochemical behaviors, ultimately constraining their practical applications and market prospects. While the material characteristics and redox mechanisms of Mn‐based cathodes are extensively investigated, a systematic iterative approach to material design that balances performance and application demands remains both necessary and urgent. Recent strategies for enhancing cathode performances emphasize the innovative introduction and customization of composite structures in Mn‐based cathode materials to address the challenges above. This review aims to provide a comprehensive understanding of composite‐structure construction methodologies and offers practical guidelines for effectively designing high‐stability Mn‐based composite‐structure cathode materials. This encompasses the classifications of composite scales, the discussions for the extent of composite‐structure construction inside and outside of the cathode grains, and an exploration of the development potential of these materials, especially for grid‐scale applications.
Comparison of short‐term outcomes and perioperative costs in laparoscopic versus robotic surgery for rectal cancers: A real‐world cohort study using Japanese nationwide inpatient database
Authors: Hamamoto Hiroki , Ota Masato , Shima Takafumi , Kuramoto Toru , Kitada Kazuya , Taniguchi Kohei , Asakuma Mitsuhiro , Oura Yasuhiro , Ito Yuri , Lee Sang‐Woong 
Published: November 2024

AbstractAimMany studies have revealed the benefits of robotic surgery for rectal cancer; however, real‐world data are insufficient. This study aimed to compare the short‐term outcomes and perioperative costs of laparoscopic and robotic surgery for rectal cancer using a real‐world database.MethodsThe data of patients who underwent laparoscopic or robotic surgery for rectal cancer between January 2018 and January 2021 from a nationwide Japanese inpatient database provided by Medical Data Vision Co., Ltd. were analyzed. We performed propensity score matching (PSM) analysis to compare the in‐hospital mortality, morbidity, readmission rate, reoperation rate, length of postoperative stay, and medical costs between the two groups.ResultsWe performed PSM analysis on 18 952 eligible patients. After PSM, 1396 patients in the laparoscopic group and 1396 in the robotic group were compared. The robotic group had a lower surgical site infection rate (2.9% vs. 1.5%, p = 0.010), lower respiratory failure rate (1.3% vs. 0.6%, p = 0.049), and higher operative medical costs (1 291 371 vs. 1 312 462 JPY, p = 0.013). The total medical costs of the two groups were comparable (1 862 439 vs. 1 895 822 JPY, p = 0.051).ConclusionsPSM analysis revealed that robotic surgery was associated with better outcomes than laparoscopic surgery in terms of surgical site infection and respiratory failure rates. The operative medical costs of robotic surgery were significantly higher than those of laparoscopic surgery. However, there was no significant difference in the total medical costs between robotic and laparoscopic surgery for rectal cancer.
Optimizing supramolecular interactions within metal–organic frameworks for ultra‐high purity propylene purification
Authors: Li Tong , Zhang Lu , Wang Yong , Jia Xiaoxia , Chen Hui , Li Yongjian , Shi Qi , Sun Lin‐Bing , Li Jinping , Chen Banglin , Li Libo 
Published: November 2024

AbstractPurifying ultra‐high purity propylene (>99.995%) with an energy‐efficient adsorptive separation method is a promising yet challenging technology that remains unfulfilled. Instead of solely considering the effect of adsorbents on guest molecules, we propose a synergistic adsorption mechanism for the deep removal of propane and propyne, utilizing supramolecular interactions in both “host‐guest” and “guest‐guest” systems. Through modulation of the pore environment, Ni‐DMOF‐DM exhibits exceptionally high adsorption capacities for propane and propyne (171 and 197 cm3/g at ambient temperature and pressure, respectively), and unprecedented propane/propylene separation selectivity (2.74). Theoretical calculations confirm the geometric interactions of C‐H···π bonds and C‐H···O hydrogen bonds resulting from host‐guest interactions, alongside C‐H···H guest‐guest interactions within the confined pore space. Breakthrough experiments demonstrated that ultra‐high purity propylene (propane < 0.005% and propyne < 1.0 ppm) can be directly collected from ternary mixtures on Ni‐DMOF‐DM, achieving a productivity of up to 152.14 L/kg.
A case of penetrating neck injury in zone II treated with combined endovascular and surgical management
Authors: Nakamura Youhei , Nakao Shunichiro , Nishida Takeshi , Ito Hiroshi , Ozaki Tomohiko , Oda Jun 
Published: November 2024

AbstractBackgroundWe report a case of zone II penetrating neck trauma with active bleeding in which endovascular treatment was performed prior to neck exploration to identify and control the bleeding point.Case PresentationA man in his 50s presented to our emergency department in hemorrhagic shock stemming from a penetrating knife wound injury to the right side of his neck. He was bleeding massively from the right neck wound and oral cavity. Cervical angiography showed bleeding from the right external carotid artery and intimal injury to the right internal carotid artery. Balloon occlusion at the common carotid artery origin and distal to the injured internal carotid artery controlled active bleeding. During vascular balloon occlusion, definitive hemostatic treatment was achieved through ligation of the proximal external carotid artery.ConclusionNeck exploration combined with endovascular treatment may be one option as a treatment strategy for patients with zone II penetrating neck injury.
Global Profiling Lysine Reactivity and Ligandability with Oxidant‐Triggered Bioconjugation Chemistry
Authors: Zhou Mengya , Li Shengrong , Tan Yi , Huang Weizhen , Li Yifang , Yuan Xia , Li Zhengqiu 
Published: November 2024

AbstractDue to the high abundance and diverse functions of lysine residues, both in the interior and on the surface of proteins, the development of new methods to characterize their reactivity and ligandability could significantly expand the pool of druggable targets. To date, only a limited number of aminophilic electrophiles have been assessed for interactions with the lysine proteome, resulting in a substantial fraction remaining inaccessible to current probes. Here, to the best of our knowledge, we report the first oxidant‐triggered bioconjugation platform for in‐depth profiling of lysines. We quantified over 7000 covalently modifiable lysine residues, which significantly expands the coverage of ligandable lysines in the whole proteome. Chemical proteomics enabled the mapping of more than 100 endogenous kinases, thus providing a comprehensive landscape of ligandable catalytic lysines within the kinome. Moreover, we identified a suite of new ligandable lysines such as K60 of ENO1 and K31 of PPIA, offering insights for exploring new functional and targetable residues. These findings could provide valuable clues for the development of targeted covalent inhibitors (TCIs).