bluuebunny/crossref_metadata_2025_split huggingface dataset:
TypeTE: a tool to genotype mobile element insertions from whole genome resequencing data
Authors: Goubert Clement , Thomas Jainy , Payer Lindsay M. , Kidd Jeffrey M. , Feusier Julie , Watkins W. Scott , Burns Kathleen H. , Jorde Lynn B. , Feschotte Cedric 
Published: October 2019

ABSTRACTAlu retrotransposons account for more than 10% of the human genome, and insertions of these elements create structural variants segregating in human populations. Such polymorphic Alu are powerful markers to understand population structure, and they represent variants that can greatly impact genome function, including gene expression. Accurate genotyping of Alu and other mobile elements has been challenging. Indeed, we found that Alu genotypes previously called for the 1000 Genomes Project are sometimes erroneous, which poses significant problems for phasing these insertions with other variants that comprise the haplotype. To ameliorate this issue, we introduce a new pipeline -- TypeTE -- which genotypes Alu insertions from whole-genome sequencing data. Starting from a list of polymorphic Alus, TypeTE identifies the hallmarks (poly-A tail and target site duplication) and orientation of Alu insertions using local re-assembly to reconstruct presence and absence alleles. Genotype likelihoods are then computed after re-mapping sequencing reads to the reconstructed alleles. Using a ‘gold standard’ set of PCR-based genotyping of >200 loci, we show that TypeTE improves genotype accuracy from 83% to 92% in the 1000 Genomes dataset. TypeTE can be readily adapted to other retrotransposon families and brings a valuable toolbox addition for population genomics.
Hypothalamic C2-domain protein involved in MC4R trafficking and control of energy balance
Authors: Gavini Chaitanya K , Cook Tyler M , Rademacher David J , Mansuy-Aubert Virginie 
Published: October 2019

ABSTRACTObjectiveRates of overweight and obesity epidemic have risen significantly in the past few decades, and 34% of adults and 15-20% of children and adolescents in the United States are now obese. Melanocortin receptor 4 (MC4R), contributes to appetite control in hypothalamic neurons and is a target for future anti-obesity treatments (such as setmelanotide) or novel drug development effort. Proper MC4R trafficking regulation in hypothalamic neurons is crucial for normal neural control of homeostasis and is altered in obesity and in presence of lipids. The mechanisms underlying altered MC4R trafficking in the context of obesity is still unclear. Here, we discovered that C2CD5 expressed in the hypothalamus is involved in the regulation of MC4R endocytosis. This study unmasked a novel trafficking protein nutritionally regulated in the hypothalamus providing a novel target for MC4R dependent pathways involved in bodyweight homeostasis and Obesity.MethodsTo evaluate the expression of C2cd5, we first used in situ hybridization and RNAscope technology in combination with electronic microscopy. For in vivo, we characterized the energy balance of wild type (WT) and C2CD5 whole-body knockout (C2CD5KO) mice fed normal chow (NC) and/or western-diet (high-fat/high-sucrose/cholesterol) (WD). To this end, we performed comprehensive longitudinal assessment of bodyweight, energy balance (food intake, energy expenditure, locomotor activity using TSE metabolic cages), and glucose homeostasis. In addition, we evaluated the consequence of loss of C2CD5 on feeding behavior changes normally induced by MC4R agonist (Melanotan, MTII) injection in the paraventricular hypothalamus (PVH). For in vitro approach, we tease out the role of C2CD5 and its calcium sensing domain C2 in MC4R trafficking. We focused on endocytosis of MC4R using an antibody feeding experiment (in a neuronal cell line - Neuro2A (N2A) stably expressing HA-MC4R-GFP; against HA-tag and analyzed by flux cytometry).ResultsWe found that 1) the expression of hypothalamic C2CD5 is decreased in diet-induced obesity models compared to controls, 2) mice lacking C2CD5 exhibit an increase in food intake compared to WT mice, 3) C2CD5 interacts with endocytosis machinery in hypothalamus, 4) loss of functional C2CD5 (lacking C2 domain) blunts MC4R endocytosis in vitro and increases MC4R at the surface that fails to respond to MC4R ligand, and, 5) C2CD5KO mice exhibit decreased acute responses to MTII injection into the PVH.ConclusionsBased on these, we conclude that hypothalamic C2CD5 is involved in MC4R endocytosis and regulate bodyweight homeostasis. These studies suggest that C2CD5 represents a new protein regulated by metabolic cues and involved in metabolic receptor endocytosis. C2CD5 represent a new target and pathway that could be targeted in Obesity.
Social value creation by multinational enterprises
Authors: Rygh Asmund 
Published: October 2019

PurposeThis study aims to discuss an argument that the social value creation of multinational enterprises (MNEs), beyond creating economic value for the shareholders, could be the next “big question” for international business (IB) research. The authors also provide examples of promising research topics associated with this research agenda.Design/methodology/approachThe paper is conceptual.FindingsAlthough a new paradigmatic question for IB in terms of social value creation would lead IB outside familiar territory in terms of the previous focus on financial performance, IB scholars are well equipped to take on this broader question. IB scholars arguably have their key strengths in understanding the inner workings of firms, as well as in understanding the role of context for business. Moreover, to the extent that this new agenda requires IB scholars to acquire new capabilities and form new partnerships with relevant disciplines, this could contribute to revitalising the IB field. As illustrated by the suggested topics, such an agenda could both increase the relevance of IB research and contribute to theory development.Originality/valueThe paper is amongst the first to explore the notion that a broader view of the outcome of MNE activities, beyond MNEs’ own financial outcomes, should be a key goal of future IB research.
A chaotic circuit under a new classification framework of inductorless Chua’s circuits
Authors: Zhu Lei , Pan Minghai , Qiao Xiaohua 
Published: October 2019

Purpose
This paper aims to classify the inductorless Chua’s circuits into two types from the topological structures and construct a chaotic circuit under this new classification framework.

Design/methodology/approach
In this paper, two types of inductorless Chua’s circuit models are presented from topological structure, among which the first type of inductorless Chua’s circuit (FTICC) model is much closer to the original Chua’s circuit. Under this classification framework, a new inductorless Chua’s circuit that belongs to the FTICC model is built by replacing LC parallel resonance of the original Chua’s circuit with a second order Sallen–Key band pass filter.

Findings
Compared with a paradigm of a reported inductorless Chua’s circuit that belongs to the second type of inductorless Chua’s circuit (STICC) model, the newly proposed circuit can present the attractors which are much more closely to the original Chua’s attractors. The dynamical behaviors of coexisting period-doubling bifurcation patterns and boundary crisis are discovered in the newly proposed circuit from both numerical simulations and experimental measurements. Moreover, a crisis scenario is observed that unmixed pairs of symmetric coexisting limit cycles with period-3 traverse through the entire parameter interval between coexisting single-scroll chaotic attractors and double-scroll chaotic attractor.

Originality/value
The newly constructed circuit enriches the family of inductorless Chua’s circuits, and its simple topology with small printed circuit board size facilitates the various types of engineering applications based on chaos.
Thermal and mechanical design of reverting microchannels for cooling disk-shaped electronic parts using constructal theory
Authors: Dadsetani Reza , Salimpour Mohammad Reza , Tavakoli Mohammad Reza , Goodarzi Marjan , Pedone Bandarra Filho Enio 
Published: October 2019

Purpose
The purpose of this study is to study the simultaneous effect of embedded reverting microchannels on the cooling performance and mechanical strength of the electronic pieces.

Design/methodology/approach
In this study, a new configuration of the microchannel heat sink was proposed based on the constructal theory to examine mechanical and thermal aspects. Initially, the thermal-mechanical behavior in the radial arrangement was analyzed, and then, by designing the first reverting channel, maximum temperature and maximum stress on the disk were decreased. After that, by creating second reverting channels, it has been shown that the piece is improved in terms of heat and mechanical strength.

Findings
Having placed the second reverting channel on the optimum location, the effect of creating the third reverting channel has been investigated. The study has shown that there is a close relationship between the maximum temperature and maximum stress in the disk as maximum temperature and maximum stress decrease in pieces with more uniform distribution channels.

Originality/value
The proposed structure has decreased the maximum temperature and maximum thermal stresses close to 35 and 50%, respectively, and also improved the mechanical strength, with and without thermal stresses, about 40 and 24%, respectively.
Housing practices and livelihood challenges in the hazard-prone contested spaces of rural Bangladesh
Authors: Kashem Shakil Bin 
Published: October 2019

Purpose
Disaster-resistant housing practices are widely promoted in developing countries as an integral component of climate adaptation efforts, particularly in rural hazard-prone areas. However, how the prevailing housing practices are intertwined with rural livelihoods and how the external initiatives to promote disaster-resistant housing practices materialize in a contested marginalized space are key questions with social vulnerability implications that seldom receive adequate attention. This paper aims to explore these questions through case studies of two hazard-prone rural areas in Bangladesh.

Design/methodology/approach
The two study areas were selected considering the variation of risk patterns: one located in cyclone hazard-prone southern District of Noakhali and the other located in a flood hazard-prone area of Rajbari District. Existing housing practices in these two communities, their adoption of disaster-resistant housing options and their overall livelihood challenges were explored through questionnaire surveys, focus group discussions and transect walks.

Findings
As this study shows, safe housing practices are tertiary concerns for people living in those contested spaces after meeting livelihood challenges. Further, in the absence of formal land tenure, adaptation efforts that introduce disaster-resistant housing practices may fail to be effective.

Practical implications
The findings of this study demonstrate the need for a reorientation in the present approaches of climate adaptation (particularly, in case of housing practice) to make them more responsive to the adaptation challenges of socially vulnerable populations.

Originality/value
Most of the prior studies on disaster and rural housing have focused on the post-disaster housing recovery, but there is yet to have enough study that looked at households’ current housing strategies and, in particular, how land tenure and livelihood challenges influence their choices. This study fills this research gap and also provides evidence in support of considering the risk priority of marginalized vulnerable population while responding to the broader concerns of climate change.
Conceptualizing the implementation of Lesson Study in Kazakhstan within a social theory framework
Authors: Wilson Elaine , Sharimova Assel 
Published: October 2019

Purpose
The purpose of this paper is to provide an analysis of processes in operation during the implementation of a reform programme in Kazakhstan culminating in the widespread adoption of Lesson Study (LS).

Design/methodology/approach
The study is positioned within a critical realist theoretical perspective, drawing on Archer’s social theory to focus on the social world of the school while changes to classroom practice are being made. This is a case study using process tracing methods to analyse how school actions and interactions are used during the change process resulting in widespread implementation of LS.

Findings
Three key mechanisms for implementing the structural changes are identified; increasing teacher’s pedagogical knowledge, collaborative working structures and active collective inquiry. The capacity to change practice is underpinned by reflection on classroom interactions and in having the necessary skills and available time to analyse the effect on pupils’ learning. Engaging in reflexive deliberation is dependent on having access to new knowledge, together with the opportunity to collaborate in supportive groups.

Originality/value
This study provides an insight into what changes were made and why these support the spread of LS in Kazakhstan, drawing on Archer’s social theory and using theory building process tracing methods to delve deeper into the empirical fingerprints left during the intervention. LS is an important structural factor which is still supporting change in Kazakhstani classrooms.
Gaming as a research method in humanitarian logistics
Authors: Lukosch Heide , Comes Tina 
Published: October 2019

Purpose
The purpose of this paper is to present a methodology for research through game design and discuss how simulation games can be used to bridge the gap between operational exercises and simulation or analytical modelling and to provide guidelines on how simulation games can be designed for different research purposes in the context of humanitarian logistics.

Design/methodology/approach
This paper combines a literature review on gaming as a research method with an analysis of requirements for humanitarian logistics research methods. Starting from this theoretical framework, the authors develop a design thinking approach that highlights how games can be used for different research purposes. To illustrate the approach, the authors develop two different game set-ups that are of increasing fidelity and complexity. Finally, the authors discuss the results of the evaluation of both approaches, reflect on the design choices and provide recommendations for research and practice.

Findings
Gaming is a suitable research method to explore and analyse behaviour and decisions in emergent settings that require team work and collaborative problem solving. Especially when safety and security concerns may hinder access and experimentation on site, gaming can offer a realistic and engaging quasi-experimental environment. The aspects of engagement and realism also make gaming a suitable tool to combine training and research.

Originality/value
Although the use of games has attracted some attention in commercial supply chain management and crisis response, there is no systematic overview of gaming as a research method in humanitarian logistics. This paper is set to make a headway in addressing this gap by proposing a concrete approach to design games for humanitarian logistics research.
Online/offline information search patterns and outcomes for services
Authors: Sa Vinhas Alberto , Bowman Douglas 
Published: October 2019

Purpose
This study aims to determine the antecedents and consequences of information source choice to support a purchase decision for services high in experience attributes.

Design/methodology/approach
The authors conduct two studies to test their propositions. Study 1 is a single-category application using data from a national survey of 974 consumers who recently made a hotel-stay purchase/reservation. Correspondence analysis was used to identify search patterns, and regression analysis was used to identify their antecedents and influence on search outcomes. Study 2 is a cross-category study using data from a survey of 422 MTurk respondents reporting on search processes across six different services contexts, including hotel reservations. In this study, the authors seek generalization of their results to other services categories.

Findings
The authors identify four dimensions that characterize what information sources consumers, on average, use together when purchasing services. It is found that loyalty program membership and consistency in service delivery across a brand’s outlets for the brands in a consumer’s evoked set are important determinants of search patterns. Search patterns partially mediate the impact of consumer characteristics, choice context and choice set characteristics on search effort and, ultimately, on price paid.

Practical implications
An understanding of the factors that are associated with consumers’ choices of information sources and whether these choices are systematically related to search outcomes has implications for market segmentation and for marketers’ initiatives with respect to what information content to emphasize across sources.

Originality/value
The contribution is an understanding of the antecedents and consequences of consumer search patterns – and what information sources consumers tend to use together, considering the diversity of both internet and non-internet sources. There are limited insights in the services literature regarding how the internet impacts information search processes.
Volunteer engagement: conceptual extensions and value-in-context outcomes
Authors: Conduit Jodie , Karpen Ingo Oswald , Tierney Kieran D. 
Published: October 2019

PurposeThe ability to attract and retain volunteers is crucial for not-for-profit organizations, and consequently, the need to understand and manage volunteers’ engagement is paramount. The purpose of this paper is to investigate the role of five volunteer engagement dimensions (cognitive, affective, behavioral, social and spiritual engagement) on perceived value-in-context, and its subsequent role for volunteer retention. Thus, providing for the first time an understanding of how unique types of value are determined through different facets of volunteer engagement.Design/methodology/approachTo establish the nature and consequences of volunteer engagement, the authors collaborated with an Australian not-for-profit service organization. Using a survey method, the authors studied the organization’s volunteer workforce resulting in 464 usable responses. To capture volunteers’ degree of spiritual engagement, this paper introduces a rigorously developed unidimensional measure.FindingsThe results demonstrate the importance of the five engagement dimensions on volunteers’ perceived value-in-context, while highlighting significant effect differences including some counterintuitive consequences. The authors also establish the role of spiritual engagement and demonstrate the impact of value-in-context for volunteer retention.Originality/valueThis research explores the volunteer engagement-retention chain, by empirically studying the role of value-in-context. The authors provide first evidence for the relationship between volunteer engagement and value-in-context, examining the independent yet relative effects of various facets of volunteer engagement. In doing so, the authors offer new insight into the dimensionality of the volunteer engagement construct, broadening its conceptualization to include spiritual engagement as a core constituent. The authors further demonstrate the impact of value-in-context on volunteer retention, helping organizations to better make sense of meaningful volunteer experiences with long-lasting impacts and mutual benefits.
Measuring causal relations and identifying critical drivers for corporate sustainability: the quadruple bottom line approach
Authors: Budsaratragoon Pornanong , Jitmaneeroj Boonlert 
Published: October 2019

PurposeThe purpose of this study is to investigate the causal interrelations among the four pillars of corporate sustainability, which indicate a firm’s contribution to environmental, social, governance and economic activities. Moreover, this study identifies the critical drivers of corporate sustainability by focusing on the levels of market developments and geographical regions.Design/methodology/approachBased on corporate sustainability data of 2,725 global companies in 2016, this study uses a combination of analytical techniques including cluster analysis, data mining, partial least square path modeling and importance performance map analysis.FindingsThis study finds that companies in European developed markets exhibit the highest-ranking of corporate sustainability. In line with the social impact hypothesis, environmental, social and governance performance positively affects economic performance. Moreover, there is strong evidence of causal relationships and synergistic effects among the four pillars of corporate sustainability. In accordance with the institutional theory, the patterns of causal directions and the critical pillars depend on levels of market developments and geographical regions. Overall, social and environmental pillars are among the most critical drivers of corporate sustainability.Research limitations/implicationsThe methodology does not aim to provide a new weighting scheme for calculating the corporate sustainability index.Practical implicationsCorporate managers should consider sustainability practices in all dimensions to benefit from synergistic effects among environmental, social, governance and economic activities. Furthermore, corporate sustainability strategies should not be generalized across countries with different levels of market developments and geographical regions.Originality/valueThis study prioritizes environmental, social, governance and economic pillars of corporate sustainability in emerging and developed markets across geographical regions.
A multi-theoretical approach on drivers of integrated reporting – uniting firm-level and country-level associations
Authors: Fuhrmann Stephan 
Published: October 2019

PurposeThis paper aims to unite firm- and country-level drivers of the disclosure of integrated reports. It creates a synopsis of voluntary disclosure, signaling, proprietary cost, legitimacy, stakeholder and institutional theory.Design/methodology/approachThe empirical analyses build on a logistic regression model examining the disclosure decisions for integrated reports published between 2012 and 2016 by the 2,000 largest listed companies worldwide.FindingsThe results indicate that the disclosure of integrated reports by large listed companies is explained in parallel by multiple theories, operationalized by the firm-level characteristics of lower profitability, a higher market-to-book value, lower leverage, lower level of industry concentration and higher social performance. Additionally, the country-level characteristics of civil law setting and lower investor protection, lower power distance and lower masculinity coincide with the disclosure of integrated reports.Originality/valueThe inferences emphasize that a single theoretical framework cannot explain the decision to disclose an integrated report. Rather, a set of economic firm characteristics may lead to different disclosure decisions in different socio-economic and institutional environments.