bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of non‐IgA vasculitis: Demographic, clinical, and treatment‐related features in a retrospective analysis of 28 biopsy‐confirmed cases from a German university hospital
Authors: Hansen‐Abeck Inga , Rünger Alessandra , Piepke Lisa , Kött Julian , Giordano‐Rosenbaum Anna , Menz Anne , Abeck Finn , Schneider Stefan W. 
Published: November 2024

AbstractNon‐IgA vasculitis is a rare disease that belongs to the group of small‐vessel vasculitides. Due to nomenclature and classification changes introduced in 2018, there are few published data under this name. The aim of this study is to characterize non‐IgA vasculitis as an independent vasculitis entity in terms of demographic, clinical, and treatment‐related features. A retrospective data analysis of patients with biopsy‐confirmed non‐IgA vasculitis treated at the Department of Dermatology at the University Medical Center Hamburg‐Eppendorf between January 1, 2018, and December 31, 2022, was performed. A total of 28 patients with non‐IgA vasculitis were included; 53.6% (15/28) were women and 42.9% (12/28) were older than 71 years. Previous infection as a possible triggering factor was found in 42.6% (12/28) of the cases. Palpable purpura was the most common skin finding (78.6%, 22/28) and 28.6% patients (8/28) had skin lesions above the waist. On direct immunofluorescence, C3 (89.3%, 25/28) was the most frequent deposition, followed by fibrinogen (71.4%, 20/28) and IgM (53.6%, 15/28). Hospitalization was required in 85.7% (24/28), with a mean hospital stay of 9.4 ± 4.1 days. No fatal courses were reported. This study is the first characterization of non‐IgA vasculitis based on patient cases from Germany and contributes to a better understanding of non‐IgA vasculitis as an independent entity. Non‐IgA vasculitis primarily affects older patients of both sexes, with most cases having an identifiable trigger. Our results indicate that cutaneous manifestations often extend beyond the lower legs. Treatment is usually required in the inpatient setting and requires a longer stay than other dermatological conditions. With proper treatment, the disease is not expected to be fatal.
Differential effects of pollen nutritional quality on male and female reproductive success within a diverse co‐flowering community
Authors: Russo Laura , Carneiro Liedson Tavares , Williams Jessica N. , Barker Daniel A. , Murray Anne , Arceo‐Gómez Gerardo 
Published: November 2024

Abstract

Pollen protein content has been demonstrated to be an essential nutritional component for bees and thus important in mediating plant–pollinator interactions. However, little is known on the drivers and consequences of among‐species variation in pollen protein content and how this can impact male and female reproductive success across plant species. Among‐species variation in resources allocated to pollen nutrition could further be constrained by life‐history strategies (e.g. survival‐reproduction trade‐offs) or evolutionary history.

Here, we surveyed pollen protein content for 29 species within a diverse co‐flowering community and evaluated the effect of pollen protein on male and female reproductive success. We also tested the role of life history (annuals vs. perennials) and phylogeny in mediating differences in resource allocation to pollen nutrition.

We found that pollen protein content influences components of male (bee visitor abundance and pollen dispersal) but not female (conspecific pollen deposition and pollen tube growth) reproductive success, suggesting this trait affects plants only via male function. This sex‐specific effect further suggests the potential for sexual conflicts driven by differential investment on this trait. We found no phylogenetic signal on pollen protein content. However, pollen protein content was higher in annual compared to perennial species suggesting survival versus reproduction trade‐offs also contribute to variation in pollen protein at the community level.

Our study underscores the importance of understanding the ecological and evolutionary drivers of pollen protein content across plant species. Our results further suggest the existence of sexual conflicts and ecological trade‐offs mediated by differential investment in pollen nutritional quality, with important implications for community assembly and the structure of plant–pollinator interactions.

Read the free Plain Language Summary for this article on the Journal blog.
A novel Fourier domain scheme for three‐dimensional magnetotelluric modelling in anisotropic media
Authors: Dai Shikun , Chen Qingrui , Li Kun , Ling Jiaxuan , Zhao Dongdong 
Published: November 2024

SUMMARYThis study presents a novel algorithm that combines the Lorenz gauge equations with the Fourier domain technique to simulate magnetotelluric responses in three‐dimensional conductivity structures with general anisotropy. The method initially converts the Helmholtz equations governing vector potentials into one‐dimensional differential equations in the wave number domain via the horizontal two‐dimensional Fourier transform. Subsequently, a one‐dimensional finite element method employing quadratic interpolation is applied to obtain three five‐diagonal linear equation systems. Upon solving these equations, the spatial domain fields are obtained via the inverse Fourier transform. This process guarantees the computational efficiency, memory efficiency and high parallelization of the algorithm. Moreover, an anisotropic medium iteration operator guarantees stable convergence of the method. The correctness, competence and applicability of the algorithm are verified using some synthetic models. The results demonstrate that the new method is efficient and performs well in anisotropic undulating terrain and complex structures. Compared to other Fourier domain methods and the latest edge‐based finite element algorithm, the proposed method exhibits superior computing performance. Finally, the impact of the Euler angles on the magnetotelluric responses is analysed.
Between epistemic injustice and therapeutic jurisprudence: Coronial processes involving families of autistic people, people with learning disabilities and/or mental ill health
Authors: Ryan Sara , Ribenfors Francesca , Mikulak Magdalena , Coles Deborah 
Published: November 2024

AbstractUnderstanding how and why someone dies unexpectedly is key to bereaved family members. The coronial process in England investigates instances where the cause of death is unknown, violent or unnatural and/or occurred in state detention. Families are held to be at the centre of this process and the coroner's role has extended to concern about therapeutic jurisprudence, that is, how legal processes can minimise negative consequences for participants without jeopardising due process. Therapeutic jurisprudence involves unresolved tensions, however, and an epistemic power imbalance. Within the inquest, knowledge is produced, evaluated and contested, and epistemic privilege may be unevenly distributed. The inquest is also a process that, as we demonstrate, requires epistemic courage and resistance on the part of families. Families with relatives who are autistic, have learning disabilities and/or mental ill health can experience epistemic and structural injustice before an unexpected death which makes the distinctiveness of their experiences important to understand. Here, we report on a qualitative interview project which focused on how bereaved families experience the coronial process after their relative died in receipt of health and/or social care support.
Adherence to Healthy Prepregnancy Lifestyle and Risk of Adverse Pregnancy Outcomes: A Prospective Cohort Study
Authors: Okubo Hitomi , Nakayama Shoji F. , Mito Asako , Arata Naoko , Ohya Yukihiro ,   the Japan Environment and Children's Study Group
Published: November 2024

ABSTRACTObjectiveTo quantify the association between a combination of modifiable prepregnancy lifestyle factors and the risk of adverse pregnancy outcomes (APOs).DesignProspective cohort study.SettingThe Japan Environment and Children's Study.PopulationA total of 79 703 pregnant Japanese women without chronic disease.MethodsMaternal lifestyle before pregnancy was assessed using a self‐administered questionnaire. A healthy lifestyle score (HLS, 0–5 points) was calculated based on adherence to five prepregnancy healthy lifestyle factors: healthy weight, high‐quality diet, regular physical activity, not smoking, and not drinking alcohol. Relative risks (RRs) and 95% credible intervals (CrIs) were estimated using a Bayesian log‐binomial regression model.Main Outcome MeasuresComposite APOs, defined as the development of any APO, including gestational diabetes, hypertensive disorders of pregnancy, preterm birth, low birth weight, and small‐for‐gestational‐age, transcribed from medical records.ResultsA total of 13 894 women (17.4%) experienced one or more APOs. HLS was inversely associated with the risk of APOs in a dose–response manner. Women with an HLS of 5 points had a 33% (RR 0.67; 95% CrI, 0.61–0.74) lower risk of APOs than those with the lowest HLS (0–1 points). The population attributable fraction of five healthy lifestyle factors was 10.3%. A 1‐point increase of HLS could have reduced APO cases by 6.6%.ConclusionsA higher HLS was associated with a lower risk of APOs, suggesting that adopting a healthy lifestyle before pregnancy may reduce the risk of APOs, which can increase the risk of future chronic diseases in both mother and child.
A Bayesian approach to Suchey‐Brooks age estimation from the pubic symphysis using modern American samples
Authors: Godde K. , Hens Samantha M. 
Published: November 2024

AbstractA critical component of the biological profile involves accurate estimation of the age‐at‐death of the decedent(s). While bias, inaccuracy, and population specificity have plagued age estimation methods, these issues are minimized by Bayesian statistics. Our primary analysis generated ages of transition from the published Suchey‐Brooks pubic symphysis dataset and coupled them with informative priors derived from two modern American forensic samples (Forensic Data Bank [FDB] and Forensic Anthropology Database for Assessing Methods Accuracy [FADAMA]) to test the accuracy of Bayesian analysis against the original method. Exact binomial tests assessed the accuracy of the generated age ranges; realized accuracies and bias are reported for final age ranges at various coverages. In a second analysis, the Bayesian Suchey‐Brooks parameters and original, non‐Bayesian age ranges were also applied to FADAMA. In the primary analyses, the Bayesian approach improved age estimates over traditional ranges, especially for females. Highest posterior density ranges at 95% provided realized accuracies on a holdout sample between 93% and 96% with extremely low bias for most phases. We provide lookup tables with Bayesian age ranges for various coverages. In the second analysis, realized accuracies were slightly higher in the non‐Bayesian approach for both sexes (86%–92% vs. 83%–91%), due to lower precision and likely practitioner bias in aging forensic cases. The popularity of the Suchey‐Brooks pubic symphysis aging method in modern forensic casework necessitates the use of the Bayesian approach and we encourage practitioners to utilize the lookup tables for forensic casework in the United States.
Impact of illustrated backgrounds on the automatic assessment of fingermark quality
Authors: Bonnaz Bérénice , Bécue Andy 
Published: November 2024

AbstractIn the fingermark detection field, background illustrations may negatively impact the visibility of the marks in presence. They can indeed locally reduce the contrast or mask ridge details. When conducting a research project, the choice for plain or illustrated substrates is mostly driven by the research objectives as well as the development level of the investigated technique (e.g., new reagent, comparison between two techniques, semi‐operational test). Also, it is not clear how the human assessors in charge of grading the quality of the detected fingermarks actually cope with fingermarks standing astride background prints. In recent publications, latent quality metrics (LQM) and improved latent fingerprint quality metrics (ILFQM) algorithms have been identified as potential alternatives to traditional human assessment. The authors of the present study were therefore interested in assessing the performance of these algorithms with regards to illustrated backgrounds. To reach that goal, 480 fingermarks were deposited on porous (240) and non‐porous (240) items presenting various kinds of illustrations (e.g., colored areas, writings, geometric shapes, lines). Several detection techniques were then applied in sequence: 1,2‐indanedione/zinc + ninhydrin + physical developer for porous items, and superglue fuming followed by dye‐staining or black magnetic powder for non‐porous items. A total of 884 pictures were obtained and their quality assessed by LQM and ILFQM. The results were then analyzed to determine if background prints may influence the metrics provided both algorithms, and if yes, to which extent.
Effect and mechanism of different exogenous biomolecules on the thermal‐induced gel properties of surimi: A review
Authors: Zhao Xiaoyun , Mei Ting , Cui Bing 
Published: November 2024

AbstractSurimi products are favored by domestic and foreign consumers due to their distinctive gelatinous texture, rich nutrition, and convenient consumption. Gel properties are key evaluation indicators for the quality of surimi products, which was mainly determined by the gel‐forming ability of the myofibrillar protein (MP). In recent years, the surimi processing industry has faced challenges in product quality that limits the further development, and how to effectively improve the gel properties of surimi products has become one of the key scientific problems to be solved in surimi processing industry. A viable strategy for improving the product quality involves combining surimi with exogenous additives, such as proteins, polysaccharides, and lipids, to enhance the gel‐forming ability of MP. At present, there is limited literature review to systematically investigate the role of these exogenous additives in interacting with MPs in surimi gel system and their effect on the gel properties of heat‐induced surimi. Therefore, in this review, we systematically discussed the formation mechanism and influencing factors of surimi gel, the interactions of exogenous biomolecules (proteins, polysaccharides, and lipids) with surimi protein, as well as their effects on the gel properties of surimi product. The aim of this review was to help us with a better understanding for the intrinsic action mechanisms of complex surimi system and provide some theoretical guidance for the improvement of gel quality and development of surimi products.
Plant‐based mince texture: A review of the sensory literature with view to informing new product development
Authors: Konrad Theresia , Ha Minh , Ronquest‐Ross Lisa , Smyth Heather E. , Moura Nadolny Jaqueline 
Published: November 2024

AbstractThe texture of plant‐based meat alternatives is a sensory attribute that holds a central value in consumer acceptability. The texture dimensions and drivers of liking for plant‐based mince, a popular product within plant‐based meats, are not yet fully established and literature in this area is limited. Consequently, the successful development and positioning of such products in the market next to traditional proteins is compromised, and improved product development guidelines are needed for the industry. This review aims to inform product development of what is currently known about plant‐based mince texture and where the research gaps are, particularly with respect to sensory dimensions and drivers of liking, by reviewing the present landscape of relevant sensory literature. Potential texture sensory dimensions for plant‐based mince, based on limited studies and seemingly aligning with conventional mince, are posited as juiciness, tenderness, firmness, and/or softness with a key driver of liking being juiciness, but this requires further validation utilizing robust sensory studies. A significant need exists to expand on the currently known texture dimensions and drivers alongside new ways that texture can be improved upon to more closely align to, or exceed, consumer expectations. Once this has been achieved, a robust sensory framework for developing plant‐based mince products can be used to better position plant‐based mince to effectively compete with traditional mince, and not merely cannibalize upon other brands, in the current market.
Preparation of functional supplement powder using nanoliposome‐containing marine bioactive compounds
Authors: Amiri Hadis , Shabanpour Bahare , Pourashouri Parastoo , kashiri Mahboobeh 
Published: November 2024

AbstractThe demand for marine bioactive compounds as therapeutic agents in supplements or functional foods has increased. However, their instability, bitter taste, and potential degradation during digestion have hindered their widespread use. To overcome these problems, a functional supplement powder was produced using the encapsulation technique of nanoliposomes containing shrimp lipid extract, fish oil (FO), and fish protein hydrolysate. Chitosan and whey protein concentrate (WPC) were used to coat the nanoliposomes in mono/bilayer and composite forms, followed by freeze‐drying for 72 h. The physicochemical characteristics, nutritional, in vitro release, and sensory evaluation were investigated. The WPC‐monolayer treatment exhibited the highest solubility (28.83 mg/100 g), encapsulation efficiency (97.67%), and polyunsaturated fatty acids (PUFAs). Although the mono/bilayer treatments of whey protein showed lower docosahexaenoic acid and eicosapentaenoic acid than FO, they presented a favorable amino acid profile. Compared to acidic stomach conditions, the release in the intestine was higher. Incorporating 1.5 g of the supplement powder per 100 g of milk can meet an individual's daily nutritional needs for essential amino acids and PUFAs. Therefore, encapsulating marine bioactive compounds in liposomal carriers could be a beneficial approach to their direct use as a nutritious powder.
Neural correlates associated with a family history of alcohol use disorder: A narrative review of recent findings
Authors: Cservenka Anita , Azma Sheeva 
Published: November 2024

AbstractA family history of alcohol use disorder (AUD) is associated with a significantly increased risk of developing AUD in one's lifetime. The previously reviewed literature suggests there are structural and functional neurobiological markers associated with familial AUD, but to our knowledge, no recent review has synthesized the latest findings across neuroimaging studies in this at‐risk population. For this narrative review, we conducted keyword searches in electronic databases to find cross‐sectional and longitudinal studies (2015‐present) that used magnetic resonance imaging (MRI), diffusion tensor imaging, task‐based functional MRI (fMRI), and/or resting state functional connectivity MRI. These studies were used to identify gray matter, white matter, and brain activity markers of risk and resilience in family history positive (FHP) individuals with a family history of AUD. FHP individuals have greater early adolescent thinning of executive functioning (frontal lobe) regions; however, some studies have reported null effects or greater gray matter volume and thickness relative to family history negative (FHN) peers without familial AUD. FHP individuals also have white matter microstructure alterations, such as reduced integrity of fronto‐striatal pathways. Recent fMRI studies have found greater inhibitory control activity in FHP individuals, while reward‐related findings are mixed. A growing interest in identifying intrinsic connectivity differences between FHP and FHN individuals has emerged in recent years. Familial AUD is related to both structural and functional brain alterations. Research should continue to focus on (1) longitudinal analyses with larger samples, (2) assessment of personal substance use and prenatal exposure to alcohol, (3) the effects of comorbid familial psychopathology, (4) examination of sex‐specific markers of risk and resilience, (5) neural predictors of alcohol use initiation, and (6) brain–behavior relationships. These efforts would aid the design of neurobiologically informed prevention and intervention efforts focused on this at‐risk population.
Corporate governance, blockholders, and financial distress: Global evidence
Authors: Celiktas Mehmet , Ugurlu Mine , Yilmaz Neslihan 
Published: November 2024

AbstractThis study examines the impact of corporate governance mechanisms and ownership structure on financial distress for 23 developed and 27 emerging countries across different markets and legal systems and during the crisis period. In developed markets, CEO duality increases distress, which can be mitigated through independent boards and majority blockholders. Independent boards, specifically in common‐law countries, alleviate distress, yet, may escalate the adverse impact of blockholders as independent boards may not be effective monitors. In emerging markets (EM), independent boards increase distress, potentially reflecting political appointments. Institutional blockholders hurt firm financial health, though, strategic blockholders may substitute for board monitoring in weak governance environments. During the crisis period, a larger and independent board has the potential to decrease financial distress.
N‐acetylcysteine as a treatment for substance use cravings: A meta‐analysis
Authors: Winterlind Emma L. , Malone Samantha G. , Setzer Michael R. , Murphy Mikela A. , Saunders David , Gray Joshua C. 
Published: November 2024

AbstractN‐acetylcysteine (NAC) may serve as a novel pharmacotherapy for substance use and substance craving in individuals with substance use disorders (SUDs), possibly through its potential to regulate glutamate. Though prior meta‐analyses generally support NAC's efficacy in reducing symptoms of craving, individual trials have found mixed results. The aims of this updated meta‐analysis were to (1) examine the efficacy of NAC in treating symptoms of craving in individuals with SUD and (2) explore subgroup differences, risk of bias and publication bias across trials. Database searches of PubMed, Cochrane Library and ClinicalTrials.gov were conducted in June and July of 2023 to identify relevant randomized control trials (RCTs). The meta‐analysis consisted of 9 trials which analysed data from a total of 623 participants. The most targeted substance in the clinical trials was alcohol (3/9; 33.3%), followed by tobacco (2/9; 22.2%) and multiple substances (2/9; 22.2%). Meta‐analysis, subgroup analyses and leave‐one‐out analyses were conducted to examine the treatment effect on craving symptoms and adverse events (AEs). Risk of bias assessments, Egger's tests and funnel plot tests were conducted to examine the risk of bias and publication bias. NAC did not significantly outperform placebo in reducing symptoms of craving in the meta‐analysis (SMD = 0.189, 95% CI = −0.015–0.393). Heterogeneity was very high in the meta‐analysis (99.26%), indicating that findings may have been influenced by clinical or methodological differences in the study protocols. Additionally, results indicate that there may be publication bias present. Overall, our findings are contrary to those of prior meta‐analyses, suggesting a limited impact of NAC on substance craving. However, the high heterogeneity and presence of publication bias identified warrants cautious interpretation of the meta‐analytic outcomes.