bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dawnside Wedge Current System Formed During Intense Geomagnetic Storms
Authors: Ohtani S. , Gjerloev J. W. , Anderson B. J. , Kataoka R. , Troshichev O. , Watari S. 
Published: September 2018

AbstractWe investigate the formation and development of a large‐scale current system in the dawn sector during intense geomagnetic storms. Four events are selected based on the historical ranking of the westward deflections of the morningside midlatitude magnetic field. For each event the polar distribution of equivalent currents indicates a significant intensification of the westward electrojet (WEJ), which initially takes place at postmidnight and then extends eastward covering the entire dawn sector. The longitudinal confinement of the enhanced WEJ suggests that it closes with downward and upward field‐aligned currents (FACs) at its eastern and western ends, respectively, and therefore, the entire system may be envisioned as a wedge current. It is noted, however, that the primary closure of FACs is meridional, and those upward and downward FACs are considered to be unbalanced parts of the R1 and R2 currents. In one event dipolarization was observed in the dawnside plasma sheet near the magnetic conjugate point of the enhanced WEJ, and in another event a major auroral expansion was observed in the entire dawn sector. It is therefore suggested that the formation of the wedge current system and the subsequent expansion toward dayside is an ionospheric projection of the tail current reduction extending toward the dawnside flank. This wedge current system is similar to the substorm wedge current system except that it is centered at dawn. The recurrent formation of this dawnside current wedge in intense storms suggests that this is another distinct constituent of the storm time current system.
Decadal Variability of Eddy Characteristics and Energetics in the Kuroshio Extension: Unstable Versus Stable States
Authors: Yang Haiyuan , Qiu Bo , Chang Ping , Wu Lixin , Wang Shengpeng , Chen Zhaohui , Yang Yun 
Published: September 2018

AbstractUsing the Estimating Circulation and Climate of the Ocean Phase II product, this study investigates the eddy characteristics and energetics in two dynamical regimes within the Kuroshio Extension (KE) region. Based on the empirical orthogonal function analysis, it is found that the decadal evolution of eddy kinetic energy in the KE region is characterized by a delayed negative correlation between the upstream and downstream. Besides the out‐of‐phase change in eddy activity levels, eddy characteristics and energetics in the upstream KE are also different from those in the downstream. In the upstream region, eddies are stretched in the zonal direction and the unstable state is characterized by strong eddy‐shedding processes. During these processes, cyclonic eddies are found to be formed in the first quasi‐stationary meander and finally pinched off from the KE jet. Energy budget illustrates that the eddy shedding processes are triggered by baroclinic instability, while barotropic instability becomes the dominated energy source after the meander is fully developed. Accompanied by the generation of cyclonic eddies, significant inverse energy cascade is detected. When the upstream KE is stable, the eddy activity is dominated by baroclinic instability and the inverse energy cascade occurs similarly. Distinct from the upstream, eddies in the downstream KE tend to be stretched in the meridional direction and the decadal variability of eddy kinetic energy in this region is mainly regulated by the upstream through lateral advection.
Organization and Oscillations in Simulated Shallow Convective Clouds
Authors: Dagan Guy , Koren Ilan , Kostinski Alex , Altaratz Orit 
Published: September 2018

AbstractPhysical insights into processes governing temporal organization and evolution of cloud fields are of great importance for climate research. Here using large eddy simulations with a bin microphysics scheme, we show that warm convective cloud fields exhibit oscillations with two distinct periods (~10 and ~90 min, for the case studied here). The shorter period dominates the nonprecipitating phase, and the longer period is related to the precipitating phase. We show that rain processes affect the domain's thermodynamics, hence forcing the field into a low‐frequency recharge‐discharge cycle of developing cloudiness followed by precipitation‐driven depletion. The end result of precipitation is stabilization of the lower atmosphere by warming of the cloudy layer (due to latent heat release) and cooling of the subcloud layer (by rain evaporation, creating cold pools). As the thermodynamic instability weakens, so does the cloudiness, and the rain ceases. During the nonprecipitating phase of the cycle, surface fluxes destabilize the boundary layer until the next precipitation cycle. Under conditions that do not allow development of precipitation (e.g., high aerosol loading), high‐frequency oscillations dominate the cloud field. Clouds penetrating the stable inversion layer trigger gravity waves with a typical period of ~10 min. In return, the gravity waves modulate the clouds in the field by modifying the vertical velocity, temperature, and humidity fields. Subsequently, as the polluted nonprecipitating simulations evolve, the thermodynamic instability increases and the cloudy layer deepens until precipitation forms, shifting the oscillations from high to low frequency. The organization of cold pools and the spatial scale related to these oscillations are explored.
Predicting Effective Diffusion Coefficients in Mudrocks Using a Fractal Model and Small‐Angle Neutron Scattering Measurements
Authors: Busch A. , Kampman N. , Bertier P. , Pipich V. , Feoktystov A. , Rother G. , Harrington J. , Leu L. , Aertens M. , Jacops E. 
Published: September 2018

AbstractThe determination of effective diffusion coefficients of gases or solutes in the water‐saturated pore space of mudrocks is time consuming and technically challenging. Yet reliable values of effective diffusion coefficients are important to predict migration of hydrocarbon gases in unconventional reservoirs, dissipation of (explosive) gases through clay barriers in radioactive waste repositories, mineral alteration of seals to geological CO2 storage reservoirs, and contaminant migration through aquitards. In this study, small‐angle and very small angle neutron scattering techniques have been utilized to determine a range of transport properties in mudrocks, including porosity, pore size distributions, and surface and volume fractal dimensions of pores and grains, from which diffusive transport parameters can be estimated. Using a fractal model derived from Archie's law, we calculate effective diffusion coefficients from these parameters and compare them to laboratory‐derived effective diffusion coefficients for CO2, H2, CH4, and HTO on either the same or related mudrock samples. The samples include Opalinus Shale from the underground laboratory in Mont Terri, Switzerland, Boom Clay from a core drilled in Mol, Belgium, and a marine claystone cored in Utah, USA. The predicted values were compared to laboratory diffusion measurements. The measured and modeled diffusion coefficients show good agreement, differing generally by less than factor 5. Neutron or X‐ray scattering analysis is therefore proposed as a novel method for fast, accurate estimation of effective diffusion coefficients in mudrocks, together with simultaneous measurement of multiple transport parameters including porosity, pore size distributions, and surface areas, important for (reactive) transport modeling.
Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component
Authors: Wang Jialing , Yuan Shuai , Zhu Dongjie , Tang Hao , Wang Nan , Chen Wenyuan , Gao Qiang , Li Yuhua , Wang Junzhi , Liu Hongrong , Zhang Xinzheng , Rao Zihe , Wang Xiangxi 
Published: September 2018

AbstractHerpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the α-herpesvirinae subfamily that together with the β- and γ-herpesvirinae subfamilies forms the Herpesviridae family. Here, we report the cryo-electron microscopy structure of the HSV-2 C-capsid with capsid-vertex-specific component (CVSC) that was determined at 3.75 Å using a block-based reconstruction strategy. We present atomic models of multiple conformers for the capsid proteins (VP5, VP23, VP19C, and VP26) and CVSC. Comparison of the HSV-2 homologs yields information about structural similarities and differences between the three herpesviruses sub-families and we identify α-herpesvirus-specific structural features. The hetero-pentameric CVSC, consisting of a UL17 monomer, a UL25 dimer and a UL36 dimer, is bound tightly by a five-helix bundle that forms extensive networks of subunit contacts with surrounding capsid proteins, which reinforce capsid stability.
A fully protected hydrogenase/polymer-based bioanode for high-performance hydrogen/glucose biofuel cells
Authors: Ruff Adrian , Szczesny Julian , Marković Nikola , Conzuelo Felipe , Zacarias Sónia , Pereira Inês A. C. , Lubitz Wolfgang , Schuhmann Wolfgang 
Published: September 2018

AbstractHydrogenases with Ni- and/or Fe-based active sites are highly active hydrogen oxidation catalysts with activities similar to those of noble metal catalysts. However, the activity is connected to a sensitivity towards high-potential deactivation and oxygen damage. Here we report a fully protected polymer multilayer/hydrogenase-based bioanode in which the sensitive hydrogen oxidation catalyst is protected from high-potential deactivation and from oxygen damage by using a polymer multilayer architecture. The active catalyst is embedded in a low-potential polymer (protection from high-potential deactivation) and covered with a polymer-supported bienzymatic oxygen removal system. In contrast to previously reported polymer-based protection systems, the proposed strategy fully decouples the hydrogenase reaction form the protection process. Incorporation of the bioanode into a hydrogen/glucose biofuel cell provides a benchmark open circuit voltage of 1.15 V and power densities of up to 530 µW cm−2 at 0.85 V.
A PECTIN METHYLESTERASE gene at the maize Ga1 locus confers male function in unilateral cross-incompatibility
Authors: Zhang Zhaogui , Zhang Baocai , Chen Zhibin , Zhang Dongmei , Zhang Huairen , Wang Hang , Zhang Yu’e , Cai Darun , Liu Juan , Xiao Senlin , Huo Yanqing , Liu Jie , Zhang Lanjun , Wang Mingming , Liu Xu , Xue Yongbiao , Zhao Li , Zhou Yihua , Chen Huabang 
Published: September 2018

AbstractUnilateral cross-incompatibility (UCI) is a unidirectional inter/intra-population reproductive barrier when both parents are self-compatible. MaizeGametophyte factor1(Ga1) is an intraspecific UCI system and has been utilized in breeding. However, the mechanism underlying maize UCI specificity has remained mysterious for decades. Here, we report the cloning ofZmGa1P, a pollen-expressedPECTIN METHYLESTERASE(PME) gene at theGa1locus that can confer the male function in the maize UCI system. Homozygous transgenic plants expressingZmGa1Pin aga1background can fertilizeGa1-Splants and can be fertilized by pollen ofga1plants. ZmGa1P protein is predominantly localized to the apex of growing pollen tubes and may interact with another pollen-specific PME protein, ZmPME10-1, to maintain the state of pectin methylesterification required for pollen tube growth inGa1-Ssilks. Our study discloses a PME-mediated UCI mechanism and provides a tool to manipulate hybrid breeding.
Real-world retrospective cohort study ARCTIC shows burden of comorbidities in Swedish COPD versus non-COPD patients
Authors: Ställberg Björn , Janson Christer , Larsson Kjell , Johansson Gunnar , Kostikas Konstantinos , Gruenberger Jean-Bernard , Gutzwiller Florian S. , Jorgensen Leif , Uhde Milica , Lisspers Karin 
Published: September 2018

AbstractThis study aimed to generate real-world evidence to assess the burden of comorbidities in COPD patients, to effectively manage these patients and optimize the associated healthcare resource allocation. ARCTIC is a large, real-world, retrospective cohort study conducted in Swedish COPD patients using electronic medical record data collected between 2000 and 2014. These patients were studied for prevalence of various comorbidities and for association of these comorbidities with exacerbations, mortality, and healthcare costs compared with an age-, sex-, and comorbidities-matched non-COPD reference population. A total of 17,479 patients with COPD were compared with 84,514 non-COPD reference population. A significantly higher prevalence of various comorbidities was observed in COPD patients 2 years post-diagnosis vs. reference population, with the highest percentage increase observed for cardiovascular diseases (81.8% vs. 30.7%). Among the selected comorbidities, lung cancer was relatively more prevalent in COPD patients vs. reference population (relative risk, RR = 5.97, p < 0.0001). Ischemic heart disease, hypertension, depression, anxiety, sleep disorders, osteoporosis, osteoarthritis, and asthma caused increased mortality rates in COPD patients. Comorbidities that were observed to be significantly associated with increased number of severe exacerbations in COPD patients included heart failure, ischemic heart disease, depression/anxiety, sleep disorders, osteoporosis, lung cancer, and stroke. The cumulative healthcare costs associated with comorbidities over 2 years after the index date were observed to be significantly higher in COPD patients (€27,692) vs. reference population (€5141) (p < 0.0001). The data support the need for patient-centered treatment strategies and targeted healthcare resource allocation to reduce the humanistic and economic burden associated with COPD comorbidities.
Comparative study of the toxicity between three non-steroidal anti-inflammatory drugs and their UV/Na2S2O8 degradation products on Cyprinus carpio
Authors: Gao Xingsheng , Geng Jinju , Du Yourong , Li Shaoli , Wu Gang , Fu Yingying , Ren Hongqiang 
Published: September 2018

AbstractThe efficiency of advanced oxidation processes (AOPs) for disposing of non-steroidal anti-inflammatory drugs (NSAIDs) has been widely studied, but the environmental fates and effects of the NSAIDs and their degradation products (DPs) are poorly understood. In this study, the efficiency of ultraviolet light/Na2S2O8 (UV/PS) in degrading three NSAIDs—diclofenac, naproxen, and ibuprofen—and the toxicity of their DPs on Cyprinus carpio (C. carpio) was investigated. Results showed that the three NSAIDs can be completely removed (removal rate > 99.9%) by UV/PS, while the mineralization rate of the NSAIDs was only 28%. When C. carpio were exposed to 0.1 μM NSAIDs, 10 μM persulfate (PS), and 0.1 μM DPs of the NSAIDs for 96 h, respectively, the toxicity effects are as the NSAID DPs > PS > NSAIDs. Research results into the time-dependent effect of NSAID DPs on C. carpio demonstrated that obvious toxicity effects were observed in the first 48 hours, and the toxicity effects strengthened over time. NSAID DPs may have more severe toxicity effects than NSAIDs on C. carpio; therefore, the operating conditions of UV/PS must be optimized to eliminate the ecotoxicity of DPs.
A Remember/Know Examination of Free-recall Reveals Dissociative Roles of Item- and Context-Information over Time
Authors: Sadeh Talya , Moran Rani , Stern Yonatan , Goshen-Gottstein Yonatan 
Published: September 2018

AbstractIt is well-established that the ability to freely recall information is driven by the extent to which the context at encoding is reinstated at retrieval. Still, when asked to judge the subjective quality of one’s memories giving Remember/Know (R/K) judgments, people tend to classify a substantial proportion of recalls as being devoid of context. We suggest that R- and K-recalls differ with regard to their reliance on context- and item-information, with R-recalls driven primarily by contextual-information (e.g., associations evoked by the study-items) and K-recalls driven primarily by information pertaining to the items (e.g., semantic information). Memory was tested both immediately after study and in a final free-recall test conducted ~20 minutes after encoding—a timescale which is akin to real-life events. In line with our predictions, as compared to K-recalls, R-recalls show stronger contextual effects, but similarly strong item-related effects over these timescales. Furthermore, drawing on theories regarding the forgetting of item- and contextual information, we hypothesized and found that R- and K-recalls are differentially affected by the passage of time. Our findings provide several converging pieces of evidence for differential roles of item and contextual information in driving recall and thus highlight the need to extend longstanding theories of free-recall to account for cases in which recall relies less on context.
Auxin sensing is a property of an unstructured domain in the Auxin Response Factor ETTIN of Arabidopsis thaliana
Authors: Simonini Sara , Mas Philippe J. , Mas Caroline M. V. S. , Østergaard Lars , Hart Darren J. 
Published: September 2018

AbstractThe plant hormone auxin regulates numerous aspects of the plant life cycle. Auxin signalling is mediated by auxin response factors (ARFs) that dimerise with modulating Aux/IAA repressors. ARF3 (ETTIN or ETT) is atypical as it does not interact with Aux/IAA repressors. It is proposed to be a non-canonical auxin sensor, regulating diverse functions essential for development. This sensing ability relies on a unique C-terminal ETT specific domain (ES domain). Alignments of ETT orthologues across the angiosperm phylum revealed that the length and sequence identities of ES domains are poorly conserved. Computational predictors suggested the ES domains to be intrinsically disordered, explaining their tolerance of insertions, deletions and mutations during evolution. Nevertheless, five highly conserved short linear motifs were identified suggesting functional significance. High-throughput library screening identified an almost full-length soluble ES domain that did not bind auxin directly, but exhibited a dose-dependent response in a yeast two-hybrid system against the Arabidopsis INDEHISCENT (IND) transcription factor. Circular dichroism confirmed the domain was disordered. The identification and purification of this domain opens the way to the future characterisation of the ETT auxin-sensing mechanism in planta and an improved understanding of auxin-mediated regulation.
Low-Temperature Continuous Flow Synthesis of Metal Ammonium Phosphates
Authors: Holdsworth Alistair F. , Eccles Harry , Halman Alice M. , Mao Runjie , Bond Gary 
Published: September 2018

AbstractThe synthesis of the high performance inorganic materials essential to the quality of modern day life is hindered by traditionalist attitudes and reliance on outdated methods such as batch syntheses. While continuous flow methods have been extensively adopted in pharmaceutical circles, they remain largely unexplored for the preparation of inorganic compounds, despite higher efficiency, safety and versatility. In this publication, we demonstrate a step-change for the synthesis of metal ammonium phosphates through conversion of the extant batch process to a low-temperature continuous regime, exhibiting a tenfold increase in throughput combined with a significant decrease in particle size.
A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye
Authors: Sarkar Ankita , Gogia Neha , Glenn Neil , Singh Aditi , Jones Gillian , Powers Nathan , Srivastava Ajay , Kango-Singh Madhuri , Singh Amit 
Published: September 2018

AbstractAlzheimer’s disease (AD), a fatal progressive neurodegenerative disorder, also results from accumulation of amyloid-beta 42 (Aβ42) plaques. These Aβ42 plaques trigger oxidative stress, abnormal signaling, which results in neuronal death by unknown mechanism(s). We misexpress high levels of human Aβ42 in the differentiating retinal neurons of the Drosophila eye, which results in the Alzheimer’s like neuropathology. Using our transgenic model, we tested a soy-derived protein Lunasin (Lun) for a possible role in rescuing neurodegeneration in retinal neurons. Lunasin is known to have anti-cancer effect and reduces stress and inflammation. We show that misexpression of Lunasin by transgenic approach can rescue Aβ42 mediated neurodegeneration by blocking cell death in retinal neurons, and results in restoration of axonal targeting from retina to brain. Misexpression of Lunasin downregulates the highly conserved cJun-N-terminal Kinase (JNK) signaling pathway. Activation of JNK signaling can prevent neuroprotective role of Lunasin in Aβ42 mediated neurodegeneration. This neuroprotective function of Lunasin is not dependent on retinal determination gene cascade in the Drosophila eye, and is independent of Wingless (Wg) and Decapentaplegic (Dpp) signaling pathways. Furthermore, Lunasin can significantly reduce mortality rate caused by misexpression of human Aβ42 in flies. Our studies identified the novel neuroprotective role of Lunasin peptide, a potential therapeutic agent that can ameliorate Aβ42 mediated neurodegeneration by downregulating JNK signaling.
Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma
Authors: Wong Kwan Yeung , Yao Qiumei , Yuan Ling-Qing , Li Zhenhai , Ma Edmond Shiu Kwan , Chim Chor Sang 
Published: September 2018

AbstractRAS mutations are frequent in relapsed/refractory multiple myeloma (RRMM) but functional study in primary samples is scanty. Herein, in primary myeloma plasma cells of 17 suspected RRMM, functional activation of RAS signalling was studied by Western blot of phosphorylated ERK1/2 (phospho-ERK1/2). Moreover, activating mutations in KRAS, NRAS, BRAF, and ALK were studied by PCR and bidirectional direct sequencing. Furthermore, methylation of negative RAS signalling regulator genes, RASSF1A and RASD1, were analyzed by methylation-specific PCR. As evidenced by phospho-ERK1/2 over-expression, functional RAS activation was detected in 12 (75.0%) RRMM. Of patients with functional RAS activation, sequencing data showed only seven (58.3%) patients with one each had NRAS Q61H, NRAS Q61K, KRAS G12D, KRAS G12V, KRAS G13D, KRAS Q61P, or BRAF V600E mutation, whereas five (41.7%) patients had no RAS/RAF mutation. Conversely, patients without functional RAS activation had no RAS/RAF mutation. Moreover, none of the patients with functional RAS activation had ALK mutations, or methylation of RASSF1A and RASD1. Collectively, functional activation of RAS signalling was present in majority of RRMM but only about half (58.3%) accountable by RAS/RAF mutations. If verified in larger studies, clinical investigations of MEK inhibitors are warranted regardless of RAS/RAF mutations.