bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of small noncoding RNAS in the pathogenesis of coronary arteries atherosclerosis
Authors: Polyakova E. A. , Zaraiskii M. I. , Berkovich O. A. , Baranova E. I. , Shlyakhto E. V. 
Published: October 2018

Background.Cardiovascular disease, including coronary artery disease (CAD), remains a leading cause of mortality. The results of recent studies demonstrate that microRNA engages in pathogenesis of different pathological states, including coronary atherosclerosis and its clinical manifestation — CAD.Objective.To evaluate microRNA-27а, microRNA-133а and microRNA-203 expression in cardiomyocytes and blood serum of CAD patients with different degrees of coronary artery lesion.Design and methods. 100 patients were included in the study, they formed 3 groups: 40 patients with CAD and significant atherosclerosis of 1-2 coronary arteries; 40 patients with multi arterial coronary disease and 20 persons without CAD and significant comorbidity. The microRNA-27a, microRNA-133а and microRNA-203 expression was determined in cardiomyocytes and blood serum of these patients by real-time polymerase chain reaction.Results.Level of microRNA-27a, microRNA-133а and microRNA-203 expression in left atrium cardiomyocytes of CAD patients with significant stenosis of 3 or more coronary arteries was higher, then their expression in the patients with 1-2-vessel and in group without coronary atherosclerosis. Examination of the microRNA expression level in blood serum and in left atrium cardiomyocytes revealed a significant difference. The expression of microRNA-27a and microRNA-133а in cardiomyocytes is above than in blood serum, while the expression of microRNA-203 in the myocardium is lower, than in the blood serum. Level of microRNA-27a, microRNA-133а and microRNA-203 expression in blood serum in CAD patients with significant stenosis of 3 or more coronary arteries was significantly higher, than in patients with 1-2 stenosis of coronary arteries. Furthermore, classification tree method established that risk of atherosclerotic heart disease increases five-fold if microRNA-203 expression in blood serum is more than 100 REU.Conclusion.MicroRNA-27а and microRNA-133а expression in cardiomyocytes of left atrium is higher than in blood serum in CAD patients. MicroRNA-203 expression level in blood serum may be a new predictive marker of coronary artery degree atherosclerotic stenosis in CAD patients.
Decolonizing Reflexive Practice Through Photo Essay Aisinai’pi Storying Place
Authors: Walsh Christine A. , St-Denis Natalie , Eagle Bear Anita 
Published: October 2018

In response to the Truth and Reconciliation Commission’s Calls to Action, universities across Canada are currently exploring ways to decolonize and indigenize their institutions and curriculum. The profession of social work has had an historical and ongoing role in the oppression of Indigenous Peoples, and now has the responsibility to advance and integrate Indigenous worldviews for reconciliation and healing. Storytelling has been described as an embodiment of Indigenous knowledges and validates the experiences of Indigenous Peoples. Although traditional stories have been most often shared orally, visual methods of storytelling have gained popularity among oppressed communities as a way to share their realities. This photo essay project was developed as a tool to guide social work educators and students to decolonize their reflexive practice by reflecting on their personal and professional identities in relationship to place.The photo essay presents a series of images evoking stories of original peoples and settlers on this land and fuels important questions about identity and belongingness. Keywords: Decolonization, reflexive practice, photography, storytelling
An Implementation Model for Collaborative Applications
Authors: Cortes Mauricio , Mishra Prateek 
Published: October 2018

A major challenge in building groupware systems is to provide support for control and coordina-
tion of users actions on shared resources. This support includes the maintenance of the current state of the collaborative multi-user environment such as control of group interaction rules and coordination of users actions or tasks.
We propose an extension of the visual presentation/underlying data model currently followed when developing interactive single user applications. We claim that groupware systems require two additional components: user-related data and group interaction rules. The former component maintains information about active users, their roles, and privileges. While the latter keeps the state of the current collaborative environment to control and coordinate user actions. Furthermore, our approach allows developers build each system component separately, promoting the decom- position of the application’s computational objects and its collaborative environment specifica- tion.
A Systematic Review on Anti-diabetic Properties of Chalcones
Authors: Rocha Sonia , Ribeiro Daniela , Fernandes Eduarda , Freitas Marisa 
Published: October 2018

:
The use of anti-diabetic drugs has been increasing worldwide and the evolution of
therapeutics has been enormous. Still, the currently available anti-diabetic drugs do not present
the desired efficacy and are generally associated with serious adverse effects. Thus, entirely
new interventions, addressing the underlying etiopathogenesis of type 2 diabetes mellitus,
are required. Chalcones, secondary metabolites of terrestrial plants and precursors of the
flavonoids biosynthesis, have been used for a long time in traditional medicine due to their
wide-range of biological activities, from which the anti-diabetic activity stands out.

:
This review systematizes the information found in literature about the anti-diabetic properties
of chalcones, in vitro and in vivo. Chalcones are able to exert these properties by acting in
different therapeutic targets: Dipeptidyl Peptidase 4 (DPP-4); Glucose Transporter Type 4
(GLUT4), Sodium Glucose Cotransporter 2 (SGLT2), α-amylase, α-glucosidase, Aldose Reductase
(ALR), Protein Tyrosine Phosphatase 1B (PTP1B), Peroxisome Proliferator-activated
Receptor-gamma (PPARγ) and Adenosine Monophosphate (AMP)-activated Protein Kinase
(AMPK). Chalcones are, undoubtedly, promising anti-diabetic agents, and some crucial
structural features have already been established. From the Structure-Activity Relationships
analysis, it can generally be stated that the presence of hydroxyl, prenyl and geranyl groups
in their skeleton improves their activity for the evaluated anti-diabetic targets.
Autologous Blood for Conjunctival Autograft Fixation in Primary Pterygium Surgery: A Systematic Review and Meta-analysis
Authors: Zein Hossam , Ismail Ammar , Abdelmongy Mohamed , Elsherif Sherif , Hassanen Ahmad , Muhammad Basma , Assaf Fathy , Elsehili Ahmed , Negida Ahmed , Yamane Shin , Abdel-Daim Mohamed M. , Kadonosono Kazuaki 
Published: October 2018

Objective: The study aimed to perform a systematic review and meta-analysis of randomized controlled
trials comparing the efficacy and complications of autologous blood versus using fibrin glue and surgical
sutures for conjunctival autograft fixation in primary pterygium surgery.

Design:
Systematic review with quantitative meta-analysis.

Methods:
Four authentic databases have been searched using relevant keywords. Eligible studies were obtained,
and their data were extracted into an online form. Analysis was done using Review Manager for windows. Dichotomous
outcomes were reported as risk ratio, while continuous data were reported as mean difference.

Results:
Seven studies were included in the analysis. Most of the included studies were of moderate quality according
to Cochrane Risk of Bias assessment tool. There was no difference between the three techniques in recurrence
rates (Risk Ratio (RR) 0.80, 95% CI [0.45 to 1.44], p= 0.46). Graft retraction and displacement were more
profound in the autologous blood group vs fibrin glue and suture groups (RR 3.22, 95% CI [1.48 to7.02], p=
0.003) and (RR 5.27, 95% CI [2.24 to 12.38], p> 0.001) respectively. In terms of operative time, fibrin glue took
shorter while suturing took longer time compared to blood coagulum (Mean Difference (MD) =1.57, 95% CI
[0.90, 2.25], p> 0.00001) and (MD -20.47, 95% CI [-38.05 to -2.88], p =0.02).

Conclusion:
Autologous blood for conjunctival autograft fixation in primary pterygium surgery was associated
with lower graft stability than fibrin glue or sutures. However, it did not account for higher recurrence rates than
the fibrin glue or sutures. Patient satisfaction and postoperative symptoms are relatively better in the blood coagulum
group than the other techniques. The overall quality of evidence is low. Further well designed randomized
controlled trials are still needed.
Alzheimer’s Disease: Physical Activities as an Effective Intervention Tool - A Mini-Review
Authors: Klimova Blanka , Maresova Petra , Kuca Kamil 
Published: October 2018

Background:
There are a few risk factors which definitely have an impact on the development
of Alzheimer’s disease (AD). Those include genetics, gender, age, diabetes, head injuries, and lifestyle.
Physical activity together with a healthy diet is part of people’s lifestyle. At present, there exist
several research studies showing that the physical activities can be a good intervention tool in the delay
of cognitive decline in AD.

Objective:
The aim of this study is to discuss a relationship between the physical activities and the delay
and/or maintenance of cognitive decline in AD and the types of physical activities which are especially
suitable for this delay.

Methods:
The method of this review study consists of a method of literature review analysing the data
contained in the world’s prestigious scientific databases: PubMed, Springer, Web of Science and Scopus
in the period of 2010 - 2015. In addition, a method of comparison of different research studies discussing
various aspects and factors of the correlation of physical activities and AD is used.

Results:
The findings of this review confirm that in most cases, physical activities have a positive effect
on the improvement of cognitive decline in AD.

Conclusion:
Although physical activities seem to be beneficial for people with AD, more convincing
results, particularly in the area of specific types of exercises and their impact on slowing down the cognitive
decline, respectively AD, are needed.
Design, Synthesis and Antileishmanial Activity of Naphthotriazolyl-4- Oxoquinolines
Authors: Oliveira Vanessa G. , dos Santos Faiões Viviane , Gonçalves Gabrieli B.R. , Lima Miriam F.O. , Boechat Fernanda C.S. , Cunha Anna C. , de Andrade-Neto Valter V. , de C. da Silva Fernando , Torres-Santos Eduardo C. , de Souza Maria Cecília B.V. 
Published: October 2018

Background:
Leishmaniasis is a neglected public health problem caused by several protozoanspecies
of the genus Leishmania. The therapeutic arsenal for treating leishmaniasis is quite limited,
raising concerns about the occurrence of resistant strains. Furthermore, most of these drugs were developed
more than 70 years ago and suffer from poor efficacy and safety and are not well adapted to the
needs of patients. Therefore, research on novel natural or synthetic compounds with antiparasitic activity
is urgently needed. In this paper, we evaluated the effect and the mechanism of action of
naphthotriazolyl-4-oxoquinolines on promastigotes and intracellular amastigotes of Leishmania amazonensis.

Materials and Methods:
The naphthotriazolyl-4-oxoquinoline derivatives were obtained in good to
moderate yields via the [3+2] cycloaddition reaction between 1,4-naphtoquinone and azido-4-
oxoquinoline derivatives. HMPA at 100°C was established as the best solvent and temperature condition
for this reaction. The structures of the compounds were confirmed by spectral analyses (infrared spectroscopy,
one- and two-dimensional ¹H and ¹³C NMR spectroscopy, and high-resolution mass spectrometry).
The compounds exhibited promising activities with IC50 values ranging from 0.7 to 2.0 µM
against intracellular amastigotes of Leishmania amazonensis. The most selective compound was the Npentyl-
substituted derivative, which showed a Selectivity Index (SI) of 8.6, making it less toxic than
pentamidine (SI 4.5).

Results:
Our results demonstrated that all compounds, except the N-propyl-substituted derivative, induce
ROS production by parasites early in the culture. As a proof of concept, we demonstrated that the
most selective compound was able to interfere with sterol biosynthesis in L. amazonensis.

Conclusion:
The naphthotriazolyl-4-oxoquinoline derivatives were obtained in good to moderate yields.
These conjugates have potent in vitro antileishmanial activity involving at least two different mechanisms
of action, making them promising lead compounds for the development of new therapeutic alternatives
for leishmaniasis.
Beyond PD-1/PD-L1 Axis Blockade: New Combination Strategies in Metastatic Melanoma Treatment
Authors: Giunta Emilio Francesco , Argenziano Giuseppe , Brancaccio Gabriella , Martinelli Erika , Ciardiello Fortunato , Troiani Teresa 
Published: October 2018

:
Metastatic melanoma treatment has dramatically changed in the last few years, having a
breakthrough with the introduction of targeted agents and immunotherapy. PD-1/PD-L1 pathway
is one of the physiologic mechanisms of peripheral immune tolerance, but it also represents a
mechanism of tumor immune escape. PD-1/PD-L1 inhibitors represent new immune-checkpoint
drugs currently used in metastatic melanoma treatment.

:
Resistance to PD-1/PD-L1 axis blockade, which is the main cause of therapeutic failure during
therapeutic use of these drugs, could be linked to several mechanism of immune escape. In fact,
other inhibitory receptor such as CTLA-4, LAG-3, TIM-3 and TIGIT might be co-expressed on T
cells, deleting the effect of anti-PD-1/PD-L1; overexpression of the enzyme IDO could cause immunosuppression
through the depletion of tryptophan in the tumor microenvironment; defective c
ostimulation (through reduced activity of 4-1BB and OX40 receptors) could result in T-cell
energy.

:
Combination of anti-PD-1/PD-L1 with drugs targeting inhibitory or costimulatory receptors, intracellular
pathways, enzymes or neoangiogenesis could be a possible strategy to overcome resistance
to single PD-1/PD-L1 blockade. Clinical trials evaluating combination therapies have already
showed interesting results, although most of them are still on going.
The Predictive Role of Abdominal Fat Parameters and Stone Density on SWL Outcomes
Authors: Kaya Coskun , Kaynak Yurdaer , Karabag Aral , Aykaç Aykut 
Published: October 2018

Background:
Our aim was to detect the role of radiological abdominal fat parameters by
tomography and stone density by plain X-ray on extracorporeal Shock Wave Lithotripsy (SWL)
stone-free rate.

Methods:
The patients who had undergone SWL for a single opaque renal stone < 2 cm in diameter
and proximal ureteric stone < 1 cm in diameter were collected retrospectively. The characteristics
of patients and stones were recorded. The stone attitude, HU, abdominal fat parameters, paraperirenal
fat area, perirenal infiltration and severity of hydronephrosis with pre-treatment Non-
Contrast Computed Tomography (NCCT) and stone density with radiography were evaluated by a
radiologist. Four weeks after the last SWL; all patients were evaluated by plain X-ray and categorized
as Stone Free (SF) and Residual Fragment (RF) group.

Results:
51 patients with renal stones and 88 patients with proximal ureteral stones were included
in the study. 24 (47%) and 63 (71%) patients were classified as SFfor renal and ureteral stones respectively.
Only stone size was an independent predictor for stone-free rates after SWL for renal
and proximal ureteral stones on multivariate analysis. The Receiver Operating Characteristic
(ROC) curves for renal calculi revealed that creatinine level, stone size, stone attitude, Houns-Field
Unit (HU) and Skin-to-Stone Distance (SSD) were the predictive factors for the SWL outcome (p<
0.05). The ROC curve for ureteral calculi demonstrated that HU, stone size and attitude were the
predictive factors (p< 0.05).

Conclusion:
All abdominal fat parameters and the stone density were not related to SWL failure. A
large follow-up with more patients is essential to confirm the role of radiological parameters on the
outcome of SWL.
State-of-the-art MR Imaging of Uncommon Hepatocellular Tumours: Fibrolamellar Hepatocellular Carcinoma and Combined Hepatocellularcholangiocarcinoma
Authors: Anysz-Grodzicka Agnieszka , Podgorska Joanna , Cieszanowski Andrzej 
Published: October 2018

Background:
Fibrolamellar Carcinoma (FLC) and Combined Hepatocellular-
Cholangiocarcinoma (CHC) are rare primary liver tumours, which are related to different clinical
settings. In both tumours, correlation with clinical data and laboratory tests are extremely
important.
</P><P>
Discussion: Typically, FLC is diagnosed in young patients without any chronic disease and with
normal biochemical tests, whereas CHC arises in cirrhotic patients with elevated tumour markers:
AFP and/or CA 19-9.
</P><P>
The review describes epidemiology, aetiology, pathogenesis, radiological features and treatment of
these tumours.
</P><P>
Imaging features typical for FLC are: The presence of central scar, calcifications, the large size,
heterogeneous and early contrast-enhancement.

Conclusion:
The diagnosis of CHC may be suggested in case of elevation of both AFP and CA 19-
9 or inconsistency between elevated tumour markers and imaging findings (i.e., elevated CA 19-9
and radiological features of HCC, or elevated AFP with imaging findings characteristic of ICC).
Spectroscopic and In Silico DNA Binding Studies on the Interaction of Some New N-Substituted Rhodanines with Calf-thymus DNA: In Vitro Anticancer Activities
Authors: Ali Imran , Lone Mohammad N. , Alothman Zeid A. , Badjah Ahmad Y. , Alanazi Abdullah G. 
Published: October 2018

Background:In this era of science, cancer is a black dot on the face of humankind. Consequently, the search of promising anticancer agents continues.Aims:Here we designed and synthesized new N-substituted rhodanines (RD1-7), evaluated their multispectroscopic interaction with calf thymus DNA, in silico and anticancer studies against MDA-MB-231cancer cell line.Methods:By MTT assay rhodanine RD1 was found to be the most potent with IC50 value of 72.61 μM. In addition, DNA binding studies (UV-vis and fluorescence) revealed strong binding affinity of RD1-7 with DNA (Kb in the range of 1.5-7.4 × 105 M-1). Moreover, molecular docking study, experimental DNA binding and anticancer studies are all well agreed to each other.Results:It was observed that H-bonding and hydrophobic attractions were responsible for stability of DNAcompound adducts. Besides, the reported rhodanines (RD1-7) were found as minor groove binders of DNA. Concisely, RD1-7 indicated promising pharmacological properties and hence, shows auspicious future for the development of novel anticancer agents.Conclusion:The reported rhodanines showed excellent anticancer properties. Therefore, the described rhodanines may be used as potential anticancer agents in the future.
Novel Compound from Flowers of Moringa oleifera Active Against Multi- Drug Resistant Gram-negative Bacilli
Authors: Mandal Santi M. , Chakraborty Subhanil , Sahoo Santanu , Pyne Smritikona , Ghosh Samaresh , Chakraborty Ranadhir 
Published: October 2018

Background:
The need for suitable antibacterial agents effective against Multi-drug
resistant Gram-negative bacteria is acknowledged globally. The present study was designed to
evaluate the possible antibacterial potential of an extracted compound from edible flowers of
Moringa oleifera.

Methods:
Five different solvents were used for preparing dried flower extracts. The most effective
extract was subjected to fractionation and further isolation of the active compound with the
highest antibacterial effect was obtained using TLC, Column Chromatography and reverse phase-
HPLC. Approaches were made for characterization of the isolated compound using FTIR, NMR
and Mass spectrometry. Antibacterial activity was evaluated according to the CLSI guidelines.

Results:
One fraction of aqueous acetic acid extract of M. oleifera flower was found highly
effective and more potent than conventional antibiotics of different classes against Multi-drug resistant
Gram-negative bacilli (MDR-GNB) when compared. The phytochemical analysis of the
isolated compound revealed the presence of hydrogen-bonded amine and hydroxyl groups
attributable to unsaturated amides.

Conclusion:
The present study provided data indicating a potential for use of the flowers extract
of M. oleifera in the fight against infections caused by lethal MDR-GNB.

Recommendations:
Aqueous acetic acid flower extract of M. oleifera is effective, in-vitro, against
Gram-negative bacilli. This finding may open a scope in pharmaceutics for the development of
new classes of antibiotics.
Finite Element Simulation, Analysis and Research on the Influence of 3D Printing Parameters on Forming Precision
Authors: Baoqing Zhang , Farid Mohammad Imran , Shuo Yu , Cong Cao , Zhang Shaoze 
Published: October 2018

Background:
3D printing technology is an emerging technology based on additive ideas.
Desktop-level 3D printers molded by Fused Deposition Modeling (FDM) are widely used. However,
their printing accuracy is relatively low accompanied by severe warpage, which limits its application
scope and fields. Therefore, analysis of the cause of warpage in the printing process and optimization,
has important practical significance for promoting the application of FDM printers.

Methods:
The goal of this work is to improve the forming precision of 3D prints, through the finite
element analysis software ANSYS, utilizing the life and death component innovation and coupling
the temperature field and stress field of printing speed, one of the key factors affecting the forming
precision. After the calculation and analysis, the following conclusions can be drawn: In testing with
other conditions unchanged, when the printing speed is gradually increased, the accuracy of the print
is improved first and then decreased. This method provides a new way to analyze the influence of
other factors on the forming accuracy and also provides a new way to get the best print parameters
under the combined action of many factors. We reviewed several patents related to 3D printing, its
optimization, formulations, precision and accuracy in respective field.

Results:
So, to achieve the best results, layer thickness has great influence on the molding precision.
Finally, the results were obtained by finite element analysis, finding the best printing accuracy of the
print parameters and verifying them by conducting actual printing.

Conclusion:
The research shows that the thickness of the layer has the greatest influence on the
printing accuracy in the process parameters studied.