bluuebunny/crossref_metadata_2025_split huggingface dataset:
A positively selected, common, missense variant in FBN1 confers a 2.2 centimeter reduction of height in the Peruvian population
Authors: Asgari Samira , Luo Yang , Belbin Gillian M. , Bartell Eric , Calderon Roger , Slowikowski Kamil , Contreras Carmen , Yataco Rosa , Galea Jerome T. , Jimenez Judith , Coit Julia M. , Farroñay Chandel , Nazarian Rosalynn M. , O’Connor Timothy D. , Dietz Harry C. , Hirschhorn Joel , Guio Heinner , Lecca Leonid , Kenny Eimear E. , Freeman Esther , Murray Megan B. , Raychaudhuri Soumya 
Published: February 2019

AbstractPeruvians are among the shortest people in the world. To understand the genetic basis of short stature in Peru, we examined an ethnically diverse group of Peruvians and identified a novel, population-specific, missense variant in FBN1 (E1297G) that is significantly associated with lower height in the Peruvian population. Each copy of the minor allele (frequency = 4.7%) reduces height by 2.2 cm (4.4 cm in homozygous individuals). This is the largest effect size known for a common height-associated variant. This variant shows strong evidence of positive selection within the Peruvian population and is significantly more frequent in Native American populations from coastal regions of Peru compared to populations from the Andes or the Amazon, suggesting that short stature in Peruvians is the result of adaptation to the coastal environment.One Sentence SummaryA mutation found in Peruvians has the largest known effect on height for a common variant. This variant is specific to Native American ancestry.
Triple Arginines as Molecular Determinants for Pentameric Assembly of the Intracellular Domain of 5-HT3A Receptors
Authors: Pandhare Akash , Pirayesh Elham , Stuebler Antonia G. , Jansen Michaela 
Published: February 2019

ABSTRACTSerotonin type 3A receptors (5-HT3ARs) are cation-conducting homo-pentameric ligand-gated ion channels (pLGICs) also known as the Cys-loop superfamily in eukaryotes. 5-HT3Rs are found in the peripheral and central nervous system, and they are targets for drugs used to treat anxiety, drug dependence, schizophrenia, as well as chemotherapy-induced and post-operative nausea and emesis. Decades of research of Cys-loop receptors have identified motifs in both the extracellular and transmembrane domains that mediate pentameric assembly. Those efforts have largely ignored the most diverse domain of these channels, the intracellular domain (ICD). Here we identify molecular determinants inside the ICD for pentameric assembly by first identifying the segments contributing to pentamerization using deletion constructs, and remarkably by making a small number of defined amino acid substitutions. Our work provides direct experimental evidence for the contribution of three arginines, previously implicated in governing the low conductance of 5-HT3ARs, in structural features such as pentameric assembly.
Flv1-4 proteins function in versatile combinations in O2 photoreduction in cyanobacteria
Authors: Santana-Sánchez Anita , Solymosi Daniel , Mustila Henna , Bersanini Luca , Aro Eva-Mari , Allahverdiyeva Yagut 
Published: February 2019

AbstractFlavodiiron proteins (FDPs) constitute a group of modular enzymes widespread in all life Domains. Synechocystis sp. PCC 6803 has four FDPs (Flv1-4) essential for photoprotection of photosynthesis. A direct comparison of the Mehler-like reaction (O2 photoreduction) in high Ci (3% CO2, HC) and low Ci (air level CO2, LC) acclimated cells demonstrated that the Flv1/Flv3 heterodimer is responsible for an efficient steady-state O2 photoreduction under HC, with flv2 and flv4 expression strongly down-regulated. Conversely, under LC conditions Flv1/Flv3 acts only as a transient electron sink due to competing withdrawal of electrons by the highly induced NDH-1 complex. Further, in vivo evidence is provided indicating that Flv2/Flv4 contributes to the Mehler-like reaction when naturally expressed under LC conditions, or when artificially overexpressed under HC. The O2 photoreduction driven by Flv2/Flv4 occurs down-stream of PSI in a coordinated manner with Flv1/Flv3 and supports slow and steady-state O2 photoreduction.
Quantitative proteomic profiling of tumor-associated vascular endothelial cells in colorectal cancer
Authors: Wang Guoqiang , Yang Qiongzhi , Li Maoyu , Zhang Ye , Cai Yu-xiang , Liang Xujun , Fu Ying , Xiao Zhefeng , Zhou Minze , Xie Zhongpeng , Huang Huichao , Huang Yahui , Chen Yongheng , He Qiongqiong , Peng Fang , Chen Zhuchu 
Published: February 2019

SummeryTo investigate the global proteomic profiles of vascular endothelial cells (VECs) in the tumor microenvironment and antiangiogenic therapy for colorectal cancer (CRC), matched pairs of normal (NVECs) and tumor-associated VECs (TVECs) were purified from CRC tissues by laser capture microdissection and subjected to iTRAQ based quantitative proteomics analysis. Here, 216 differentially expressed proteins (DEPs) were identified and performed bioinformatics analysis. Interestingly, these proteins were implicated in epithelial mesenchymal transition (EMT), ECM-receptor interaction, focal adhesion, PI3K-Akt signaling pathway, angiogenesis and HIF-1 signaling pathway, which may play important roles in CRC angiogenesis. Among these DEPs, Tenascin-C (TNC) was found to upregulated in the TVECs of CRC and be correlate with CRC multistage carcinogenesis and metastasis. Furthermore, the reduction of tumor-derived TNC could attenuate human umbilical vein endothelial cell (HUVEC) proliferation, migration and tube formation through ITGB3/FAK/Akt signaling pathway. Based on the present work, we provided a large-scale proteomic profiling of VECs in CRC with quantitative information, a certain number of potential antiangiogenic targets and a novel vision in the angiogenesis bio-mechanism of CRC.Summery statementWe provided large-scale proteomic profiling of vascular endothelial cells in colorectal cancer with quantitative information, a number of potential antiangiogenic targets and a novel vision in the angiogenesis bio-mechanism of CRC.
Detecting space-time clusters of dengue fever in Panama after adjusting for vector surveillance data
Authors: Whiteman Ari , Desjardins Michael R. , Eskildsen Gilberto A. , Loaiza Jose R. 
Published: February 2019

AbstractLong term surveillance of vectors and arboviruses is an integral aspect of disease prevention and control systems in countries affected by increasing risk. Yet, little effort has been made to adjust space-time risk estimation by integrating disease case counts with vector surveillance data, which may result in inaccurate risk projection when several vector species are present, and little is known about their likely role in local transmission. Here, we integrate 13 years of dengue case surveillance and associatedAedesoccurrence data across 462 localities in 63 districts to estimate the risk of infection in the Republic of Panama. Our space-time modelling approach detected the presence of five clusters, which varied by duration, relative risk, and spatial extent after incorporating vector species as covariates. Dengue prevalence (n = 49,910) was predicted by the presence of residentAedes aegyptialone, while all other covariates exhibited insignificant statistical relationships with it, including the presence and absence of invasiveAedes albopictus. Furthermore, theAe. aegyptimodel contained the highest number of districts with more dengue cases than would be expected given baseline population levels. This implies that arbovirus case surveillance coupled with entomological surveillance can affect cluster detection and risk estimation, improving efforts to understand outbreak dynamics at national scales.Author SummaryDengue cases have increased in tropical regions worldwide owing to climate change, urbanization, and globalization facilitating the spread ofAedesmosquito vectors. National surveillance programs monitor trends in dengue fever and inform the public about epidemiological scenarios where outbreak preventive actions are most needed. Yet, most estimations of dengue risk so far derive only from disease case data, ignoringAedesoccurrence as a key aspect of dengue transmission dynamic. Here we illustrate how incorporating vector presence and absence as a model covariate can considerably alter the characteristics of space-time cluster estimations of dengue cases. We further show thatAe. aegyptihas likely been a greater driver of dengue infection in high risk districts of Panama thanAe. albopictus, and provide a discussion of possible public health implications of both spatial and non-spatial model outcomes.
Measuring the innovation capability of micro enterprises in India
Authors: Raghuvanshi Juhi , Agrawal Rajat , Ghosh Prakriti Kumar 
Published: February 2019

PurposeThe development of innovation capability (IC) is a central issue for both practitioners and academicians. However, studies that investigate the dimension of IC in the context of micro-enterprises are absent. Based on capability-based view, the purpose of this paper is to identify important dimensions to build a scale to measure IC in micro-enterprises.Design/methodology/approachThe study is based on focus group discussions for item generation and questionnaire survey on a sample of 379 micro-enterprises in India. The scale is developed with the help of exploratory factor analysis and confirmatory factor analysis. Statistical tests demonstrate that the scale presents composite reliability as well as discriminant and convergent validity.FindingsThe findings show that four dimensions form IC in micro-enterprises: resources, networking, risk taking and involvement.Originality/valueThis study develops a new scale, which is a measure of IC of micro-enterprises. The implications have been recommended, which focus upon entrepreneurs, academicians and policymakers interested in developing the IC of micro-enterprises in India.
Transmedia storytelling: a potentially vital resource for CSR communication
Authors: Coombs Timothy 
Published: February 2019

Purpose
The focus of this paper is on developing a rationale for the use of transmedia storytelling in corporate social responsibility (CSR) communication. Transmedia storytelling involves telling stories across multiple platforms by multiple people that are still united by a central theme. The purpose of this paper is to develop a rationale for the application of transmedia storytelling for CSR communication and illustrate how Procter & Gamble’s “Thank You Mom” campaign demonstrates how transmedia storytelling can be found in the current CSR communication.

Design/methodology/approach
The first part of the story is theoretical development. The idea of transmedia storytelling is developed then translated into how it can be used in CSR communication. The key ideas are that the engagement with messages created by transmedia storytelling is the idea for capturing emotions in CSR messages and avoiding the backlash created by some CSR messages, such as advertising. Transmedia storytelling provides a lens for understanding and guiding the use of various social media channels in the distribution of CSR communication. A case study is they conducted to illustrate how P&G used transmedia storytelling in its “Thank You Mom” campaign. Qualitative content analysis is used to identify the plot lines in the stories and the overall storyworld that is being developed thereby illustrating how the concepts for transmedia storytelling can be applied to the case.

Findings
The results illustrate how transmedia storytelling can be applied to CSR communication and the potential benefits of this application. The primary yields are theory development for CSR communication and the insights from the case study.

Originality/value
The extant literature on strategic communication in general and CSR communication specially have shown only a passing interest in transmedia storytelling. This paper provides a very detailed rationale for applying transmedia storytelling to CSR communication and illustrates the utility of this approach with a case study. A detailed application of transmedia storytelling to CSR communication is new and can help advance both theory and practice.
Quantitative assessment of risks on construction projects using fault tree analysis with hybrid uncertainties
Authors: Shoar Shahab , Nasirzadeh Farnad , Zarandi Hamid Reza 
Published: February 2019

Purpose
The purpose of this paper is to present a fault tree (FT)-based approach for quantitative risk analysis in the construction industry that can take into account both objective and subjective uncertainties.

Design/methodology/approach
In this research, the identified basic events (BEs) are first categorized based on the availability of historical data into probabilistic and possibilistic. The probabilistic and possibilistic events are represented by probability distributions and fuzzy numbers, respectively. Hybrid uncertainty analysis is then performed through a combination of Monte Carlo simulation and fuzzy set theory. The probability of occurrence of the top event is finally calculated using the proposed FT-based hybrid uncertainty analysis method.

Findings
The efficiency of the proposed method is demonstrated by implementing in a real steel structure project. A quantitative risk assessment is performed for weld cracks, taking into account of both types of uncertainties. An importance analysis is finally performed to evaluate the contribution of each BE to the probability of occurrence of weld cracks and adopt appropriate response strategies.

Research limitations/implications
In this research, the impact of objective (aleatory) dependence between the occurrences of different BEs and subjective (epistemic) dependence between estimates of the epistemically uncertain probabilities of some BEs are not considered. Moreover, there exist limitations to the application of fuzzy set rules, which were used for aggregating experts’ opinions and ranking purposes of the BEs in the FT model. These limitations can be investigated through further research.

Originality/value
It is believed that the proposed hybrid uncertainty analysis method presents a robust and powerful tool for quantitative risk analysis, as both types of uncertainties are taken into account appropriately.
Interactive theater: an effective tool to reduce gender bias in faculty searches
Authors: Shea Christine M. , Malone Mary Fran Fran T. , Young Justin R. , Graham Karen J. 
Published: February 2019

Purpose
The purpose of this paper is to describe the development, implementation and impact evaluation of an interactive theater-based workshop by the ADVANCE program at the University of New Hampshire (UNH). The workshop is part of a larger institutional transformation program funded by the National Science Foundation.

Design/methodology/approach
This institutional transformation program relied upon a systems approach to diagnose potential causes for the underrepresentation of women faculty in certain disciplines. This revealed that increasing awareness of, and reducing, implicit gender bias among members of faculty search committees could, in time, contribute to increasing the representation of women faculty at UNH. A committee charged with developing a faculty workshop to achieve this change identified interactive theater as an effective faculty training approach. The committee oversaw the development of customized scripts, and the hiring of professional actors and a facilitator to implement the workshop.

Findings
The workshop’s effectiveness in fulfilling its goals was assessed using faculty hiring and composition data, program evaluations, participant interviews and questions in an annual faculty climate survey. Findings indicate that the representation of women faculty increased significantly at UNH since the implementation of the interactive theater workshop. Analysis of the multiple sources of data provides corroborating evidence that a significant portion of the increase is directly attributable to the workshop.

Originality/value
This paper demonstrates the effectiveness of interactive theater-based workshops in an academic environment and of the systems approach in diagnosing and solving organizational problems.
Does diversity management matter in a traditionally homogeneous culture?
Authors: Mehng Si Ahn , Sung Sang Hyeon , Leslie Lisa M. 
Published: February 2019

PurposeThe purpose of this paper is to investigate diversity management in an under-researched country by merging theoretical insights developed in the Western literature with cultural aspects of a traditionally homogeneous country, South Korea.Design/methodology/approachThis study integrates theory and research on why diversity can have either a positive (i.e. the information/decision-making paradigm) or a negative (i.e. the social categorization paradigm) effect on performance with different diversity perspectives (i.e. integration-and-learning, access-and-legitimacy, and discrimination-and-fairness). This study develops a model of when and how gender diversity affects organization performance and test the model with a sample of 177 South Korean organizations.FindingsThis study finds that gender diversity is negatively related to organization performance in South Korea. This study also finds that the effect of gender diversity is contingent on organizational diversity perspectives. Organizations with high gender diversity perform better to the extent that they have a discrimination-fairness perspective, but not a business-oriented perspective. On the other hand, a discrimination-fairness perspective is unrelated to performance for organizations that are low in gender diversity.Originality/valueAlthough gender diversity in the South Korean workplace continues to increase, the relationship between gender diversity and organization performance has rarely been studied in the aspect of Korea’s traditionally homogeneous culture. This study highlights the importance of cultural-contingencies in understanding the consequences of diversity.
How do Islamic equities respond to monetary actions?
Authors: Anwer Zaheer , Azmi Wajahat , Ramadili Mohd Shamsher Mohamad 
Published: February 2019

Purpose
The purpose of this paper is to appraise the effectiveness of monetary policy actions in variant market conditions for Islamic stocks. These stocks offer ground for a natural experiment as they have restrictions on the line of business and their distinguished capital structure does not allow them to combat the liquidity crisis through the use of leverage.

Design/methodology/approach
The paper uses the quantile regression approach for a multi-country sample of Islamic stock indices to assess the impact of domestic as well as US expansionary monetary policy on stock returns of Islamic indices at various locations of distribution of returns.

Findings
It is found that, at lower return levels, an expansionary monetary policy has a negative effect on the returns. In other cases, there is no significant impact of policy rate change on index returns.

Research limitations/implications
It is more appropriate to use firm level data of Islamic stocks instead of stock indices. However, the information regarding index constituents is not publicly available.

Practical implications
The paper offers useful information to investors and policy makers. It shows that central banks should improve their credibility for monetary policy to be effective and their policies must be designed keeping in view the strong impact of US rate on global monetary environment.

Originality/value
This paper provides first empirical evidence of the impact of discount rates on the returns of Islamic stocks in different market conditions.
Small winery-restaurant relationship building: challenges and opportunities
Authors: Velikova Natalia , Canziani Bonnie , Williams Helena 
Published: February 2019

Purpose
Wine is an important profit center for restaurants. The purpose of this paper is to address some of the challenges and opportunities at the nexus of wine and hospitality, with an eye on relationship building between smaller wineries and dining establishments.

Design/methodology/approach
The paper is essay style with acknowledgments made to extant literature, as well as US industry-based intelligence.

Findings
Primary challenges facing small wineries trying to enter the restaurant market revolve around constraints imposed by the traditional distribution system mindset, as well as pricing issues affecting procurement and markup of wine for restaurant use, limited abilities to provide sufficient inventory and the lack of time and people resources. Counterpoint discussion reveals opportunities related to increased focus on experience-based wine sales in restaurants, the importance of the story and the value of co-branding.

Practical implications
Partnerships with restaurants can be a delicate yet desirable part of a small winery’s strategy. The key is to develop a mutually beneficial relationship, while fulfilling the objectives and missions of both winery and restaurant. When wineries and restaurants carve out the time and invest the people resources to successfully and purposefully co-brand, optimum symmetry is formed which leads to mutually valued dining and special gastronomic experiences for the winery/restaurant partners and their customers.

Originality/value
In a viewpoint format, the paper outlines and discusses the key elements of relationship building between small wineries and restaurants.
Perceptions of culturally responsive pedagogy in teaching SEL
Authors: Barnes Tia Navelene , McCallops Kathleen 
Published: February 2019

Purpose
The purpose of this paper is to examine educators’ beliefs, perceptions and use of culturally responsive practices in implementing a social-emotional learning (SEL) intervention.

Design/methodology/approach
Focus groups with school personnel in a school with a diverse student population that had sustained success with an SEL intervention were conducted. Grounded theory was used to analyze data.

Findings
The analyses produced 11 interrelated themes.

Practical implications
School personnel noted that instruction in culturally responsive practices was foundational and should occur before SEL intervention implementation commences to ensure the use of culturally responsive practices as part of SEL implementation. Moreover, they noted the importance of school community buy-in (administrator, faculty, staff, parent and student) in supporting school-based SEL intervention sustainability.

Social implications
Within the USA, continued diversification of the student population is predicted, while the teaching force is projected to remain primarily White, middle class and female. Consequently, educators often differ in cultural background from their students, which has implications for SEL instruction. Incorporating the use of culturally responsive pedagogy in teaching SEL skills is one approach to addressing this cultural mismatch.

Originality/value
There are currently few studies that explore educator perceptions of SEL and no studies that examine the use of culturally responsive pedagogy in teaching SEL.