bluuebunny/crossref_metadata_2025_split huggingface dataset:
NetPyNE: a tool for data-driven multiscale modeling of brain circuits
Authors: Dura-Bernal Salvador , Suter Benjamin A , Gleeson Padraig , Cantarelli Matteo , Quintana Adrian , Rodriguez Facundo , Kedziora David J , Chadderdon George L , Kerr Cliff C , Neymotin Samuel A , McDougal Robert , Hines Michael , Shepherd Gordon M G , Lytton William W 
Published: November 2018

AbstractBiophysical modeling of neuronal networks helps to integrate and interpret rapidly growing and disparate experimental datasets at multiple scales. The NetPyNE tool (www.netpyne.org) provides both programmatic and graphical interfaces to develop data-driven multiscale network models in NEURON. NetPyNE clearly separates model parameters from implementation code. Users provide specifications at a high level via a standardized declarative language, e.g., a connectivity rule, instead of tens of loops to create millions of cell-to-cell connections. Users can then generate the NEURON network, run efficiently parallelized simulations, optimize and explore network parameters through automated batch runs, and use built-in functions for visualization and analysis – connectivity matrices, voltage traces, raster plots, local field potentials, and information theoretic measures. NetPyNE also facilitates model sharing by exporting and importing using NeuroML and SONATA standardized formats. NetPyNE is already being used to teach computational neuroscience students and by modelers to investigate different brain regions and phenomena.
Nonsynonymous A-to-I RNA editing contributes to burden of deleterious missense variants in healthy individuals
Authors: Mai Te-Lun , Chuang Trees-Juen 
Published: November 2018

ABSTARCTAdenosine-to-inosine (A-to-I) RNA editing is a very common post-transcriptional modification that can lead to A-to-G changes at the RNA level and compensate for G-to-A genomic changes to a certain extent. It has been shown that each healthy individual can carry dozens of missense variants predicted to be severely deleterious. Why strongly detrimental variants are preserved in a population and not eliminated by negative natural selection remains mostly unclear. Here we ask if RNA editing correlates with the burden of deleterious A/G polymorphisms in a population. Integrating genome and transcriptome sequencing data from 447 human lymphoblastoid cell lines, we show that nonsynonymous editing activities (prevalence/level) are negatively correlated with the deleteriousness of A-to-G genomic changes and positively correlated with that of G-to-A genomic changes within the population. We find a significantly negative correlation between nonsynonymous editing activities and allele frequency of A within the population. This negative editing-allele frequency correlation is particularly strong when editing sites are located in highly important genes/loci. Examinations of deleterious missense variants from the 1000 genomes project further show a significantly higher mutational burden in G-to-A changes than in other types of changes. The level of the mutational burden in G-to-A changes increases with increasing deleterious effects of the changes. Moreover, the deleteriousness of G-to-A changes is significantly positively correlated with the percentage of binding motif of editing enzymes at the variants. Overall, we show that nonsynonymous editing contributes to the increased burden of G-to-A missense mutations in healthy individuals, expanding RNA editing in pathogenomics studies.
Amorphous Silicon with Extremely Low Absorption: Beating Thermal Noise in Gravitational Astronomy
Authors: Birney I. A. , Steinlechner J. , Tornasi Z. , MacFoy S. , Vine D. , Bell A. S. , Gibson D. , Hough J. , Rowan S. , Sortais P. , Sproules S. , Tait S. , Martin I. W. , Reid S. 
Published: November 2018

Amorphous silicon has ideal properties for many applications in fundamental research and industry. However, the optical absorption is often unacceptably high, particularly for gravitational-wave detection. We report a novel ion-beam deposition method for fabricating amorphous silicon with unprecedentedly low unpaired electron-spin density and optical absorption, the spin limit on absorption being surpassed for the first time. At low unpaired electron density, the absorption is no longer correlated with electron spins, but with the electronic mobility gap. Compared to standard ion-beam deposition, the absorption at 1550 nm is lower by a factor of ≈100. This breakthrough shows that amorphous silicon could be exploited as an extreme performance optical coating in near-infrared applications, and it represents an important proof of concept for future gravitational-wave detectors.

© 2018 American Physical Society
2018
American Physical Society
New hail impact simulation models on composite laminated wing leading edge
Authors: Kustron Kamila , Horak Vaclav , Doubrava Radek , Goraj Zdobyslaw Jan 
Published: November 2018

PurposeThe risk of hail-impact occurrence that can decrease local strength property must be taken into account in the design of primary airframe structures in aviation, energy and space industries. Because of the high-speed of hail impact in operation, it can affect the load carrying capacity. Testing all impact scenarios onto real structure is expensive and impractical. The purpose of this paper is to present a cost-effective hybrid testing regime including experimental tests and FEM-based simulations for airframe parts that are locally exposed to the impacting hail in flight.Design/methodology/approachTested samples (specimens) are flat panels of laminated and sandwich carbon/epoxy composites that are used in designing lightweight new airframes. The presented numerical simulations provide a cost effective and convenient tool for investigating the hail impact scenarios in the design process. The smoothed particle hydrodynamics (SPH) technique was selected for the simulation of projectiles. The most commonly used shape of projectiles in hail impact tests is the ice ball with a defined diameter. The proposed simulation technique was verified and validated in tests on flat composite panels (specimens).FindingsIntegration of the numerical analyses with high-speed impact tests of hail onto flat laminated and sandwich composite shells has been presented, and a developed simulation model for impact results assessment was obtained.Originality/valueThe tested coupons (specimens) are flat panels as representative of structural design deployed in real aircraft structures. These numerical simulations provide a cost effective and convenient tool for hail impact scenarios in the design process.
Patient’s reaction after health-care service failure: qualitative study
Authors: Bousnina Zeineb , Zaiem Imed 
Published: November 2018

Purpose
This paper aims to show the impact of service failure and to shed light on the vengeance of consumer in the health-care service.

Design/methodology/approach
A qualitative research through a retrospective study based on individual interviews was conducted. As this study is a sensitive topic, projective techniques were used to complement individual interviews, especially with care consumers who are reluctant subjects who prefer methods which preserve confidentiality. Practically, drawing interpretations method was used. The use of these drawings is to encourage reluctant interviewee to discuss on the study’s sensitive theme.

Findings
Empirical findings allowed first to approach care service failure in Tunisia that is an emerging post-revolutionary country-owned MENA. In this context, a comparison between the public and private sectors was proposed. Moreover, the results helped to understand service failure’s consequences related to patient’s reaction.

Practical implications
The Ministry of Health in collaboration with managers of public and private medical institutions will have to work on capitalization of knowledge, especially those learned from unsuccessful experiences.

Originality/value
Medical service failure can have multiple sources. The care consumer’s reaction to these failures can sometimes be extreme in form of revenge.
Music’s role in peacebuilding
Authors: Wu Haishang 
Published: November 2018

Purpose
The purpose of this paper is to promote communication by using music, and through mutual understanding and culture exchange to establish world peace.

Design/methodology/approach
The research explains why music promotes world peace and gives examples through empirical research and statistics.

Findings
Music (those genres with harmonious melodies, with peaceful purposes and without religious, political objectives) can break down the borders of nation states and bind humanity together. Quoting J.J. Keki’s words: “Peace will begin with simple people.” “We should use whatever we have to create peace. If you think you have the body, use the body to bring peace; if you have music, use your music.” Music contains huge potential of contribution to peacebuilding, such as removal of direct and indirect violence, igniting hope and will of life and help integrating peacefully among communities.

Originality/value
Peacebuilding should not remain as a theoretical idea, as it is argued that it is useful to implement within daily life. Music is a language of communication which can remove hostility. While potentially a good tool for constructing harmony, music can, however, also result in deleterious effects, if it is misused.
Financial flexibility, managerial efficiency and firm life cycle on firm performance
Authors: Chang Heng-Yu , Ma Chun-Ai 
Published: November 2018

Purpose
As the capital market in China is still developing, several constraints on a Chinese-listed firm’s financing strategy have a direct impact on its financial flexibility. The purpose of this paper is to reconstruct traditional financial flexibility index (FFI) derived from the western context, provide empirical evidence within eastern context by modified FFI and examine how the managerial efficiency of Chinese-listed firms is demonstrated with modified FFI to escort corporate life cycle hypothesis.

Design/methodology/approach
By tailored FFI to fit the contemporary operations of Chinese-listed firms, this study investigates how managerial efficiency varies across different life stages to demonstrate the moderating power in the firm performance of financially flexible firm.

Findings
It is found that financially flexible firms in the Chinese stock market generally experience good firm performance, yet the managerial efficiency could gradually be diminishing at their mature stage even firms’ financial flexibility remains consistent with the agency theory. This paper sheds light on the necessity to reexamine the components in financial flexibility based on the eastern context, and provides avenue to further understand the managerial behavior of Chinese listed firms when considering firm life cycles.

Research limitations/implications
Although it is difficult for this current study to offer the precise weights on each factor in calculating financial flexibility, the judgment matrix method is adopted to at least provide reliable estimates in accordance with Chinese business contexts with less than 10 percent errors in contrast to the actual weights.

Practical implications
This modified FFI is particularly suitable for Chinese-listed firms under certain unique financial reporting regulations by adjusting a number of weights and factors. This study may help practitioners understand the managerial conduct of publicly listed firms in China.

Originality/value
The paper constructs a modified FFI with Chinese stock market characteristics embedded, and provides insightful evidence to explain the new pecking order theory by considering the life cycle stage of Chinese-listed companies.
Crises through the consumer lens: the role of trust, blame and risk
Authors: Vassilikopoulou Aikaterini , Lepetsos Apostolos , Siomkos George 
Published: November 2018

Purpose
This paper aims to examine consumer reactions during product-harm crises by measuring the impact of perceived risk, blame and trust on consumer purchase intentions. Moreover, the role of perceived crisis severity is examined as affecting the three main endogenous variables of the conceptual framework.

Design/methodology/approach
The study uses the real-scenario approach for empirically testing the proposed conceptual framework. Participants were called to assess the story of a defective product (i.e. a soother that was recently recalled).

Findings
Results of the equation modeling demonstrate that perceived severity significantly influence trust and blame while it does not affect perceived risk. In addition, trust, blame and perceived risk notably affect purchase intentions.

Practical implications
Based on the study’s results, companies could implement appropriate strategies for reducing the negative consequences of a product-harm crisis.

Originality/value
The paper presents four key originality traits: Crisis management from the consumer perspective has received little attention. The relationship between trust, perceived risk and purchase intentions has not been explored in the crisis management field. Attribution of blame is a new variable added to the perceived risk-trust-purchase intention model. Perceived severity is examined as a moderator affecting the main endogenous variables of the conceptual framework.
Psychological empowerment and stress: role of personality and power distance
Authors: Tripathi Nachiketa , Bharadwaja Manaswita 
Published: November 2018

PurposeThe negative links between psychological empowerment (PE) and perceived stress may be arguable when evaluated in Indian work settings characterized by socio-cultural values like dependence proneness and high power distance. To explore this possibility, the present study aimed to examine the links between PE at work and perceived stress in the Indian milieu. Potential moderating effects of gender, personality (generalized self-efficacy and Big-5 traits) and power distance on this relationship were also investigated.Design/methodology/approachAn experiment with 2 (high PE/low PE) × 2 (male/female) between-subjects design was used on 120 employees from four commercialized banks. PE was manipulated by presenting a work scenario to each participant, where employees experience either high or low PE. Relevant scales were used to measure perceived stress, personality and power distance.FindingsPE has a significant negative relationship with perceived stress, thus validating the effectiveness of PE in Indian work settings. Emotional stability and agreeableness are established as significant moderators which enhanced the negative links between PE and perceived stress.Originality/valueThe current research has uniquely contributed to the limited literature regarding the role of personality in empowerment and its outcomes. Furthermore, it has captured the theoretical and practical underpinnings of the PE-perceived stress link in Indian work-context.
Business model innovation: a review and research agenda
Authors: Wahyono Wahyono 
Published: November 2018

Purpose
This paper aims to review and synthesise the recent advancements in the business model literature and explore how firms approach business model innovation.

Design/methodology/approach
A systematic review of business model innovation literature was carried out by analysing 219 papers published between 2010 and 2016.

Findings
Evidence reviewed suggests that rather than taking either an evolutionary process of continuous revision, adaptation and fine-tuning of the existing business model, or a revolutionary process of replacing the existing business model, firms can explore alternative business models through experimentation, open and disruptive innovations. It was also found that changing business models encompasses modifying a single element, altering multiple elements simultaneously, and/or changing the interactions between elements in four areas of innovation: value proposition, operational value, human capital and financial value.

Research limitations/implications
Although this review highlights the different avenues to business model innovation, the mechanisms by which firms can change their business models and the external factors associated with such change remain unexplored.

Practical implications
The business model innovation framework can be used by practitioners as a “navigation map” to determine where and how to change their business models.

Originality/value
Because conflicting approaches exist in the literature on how firms change their business models, this review synthesises these approaches and provide a clear guidance as to the ways through which business model innovation can be undertaken.
User-generated place brand identity: harnessing the power of content on social media platforms
Authors: Taecharungroj Viriya 
Published: November 2018

PurposeThe purpose of this paper is to use user-generated content (UGC) on social media platforms to infer the possible place brand identities of two famous metropolitan areas in Bangkok, Thailand, namely, Khaosan Road and Yaowarat (Bangkok’s Chinatown), both of which are famous for their street vendors and nightlife. These two places are interesting study sites because of recent identity conflicts among their stakeholders. The method developed in this research can help other places to better understand place brand identities and, as such, effectively plan for and manage those places.Design/methodology/approachThe author used content analysis to study 782 user-generated images on Flickr and 9,633 user-generated textual reviews of Khaosan Road and Yaowarat from TripAdvisor and Google Maps’ Local Guide. MAXQDA was used to code all the images. User-generated textual reviews were studied using Leximancer. The author also introduced a positivity of concept analysis to identify positive and negative components of place brand identity.FindingsThe author developed a place brand identity framework that includes three pillars, namely, place physics, place practices and place personality. Content analysis of the images generated 105 codes and a count of the frequency of the codes that represent place brand identity. Content analysis of textual reviews created the concepts in the three pillars and identified the positive and negative concepts for both places. The results of both image and text analyses showed that street food vending is one of the most salient components of place brand identity for both Khaosan Road and Yaowarat.Practical implicationsThe author suggested several place branding strategies for the Bangkok Metropolitan Administration such as turning Khaosan Road into a music scene for both visitors and locals, controlling excessive and aggressive commercialism, sponsoring the production of creative and authentic content, initiating a compelling online campaign that focusses on the items sold in Yaowarat, hosting a spotlight event such as a seafood festival and improving hygiene and walkability.Originality/valueBoth the advancement of digital technologies and the complexity of stakeholders create a need for empirical studies on place branding involving the participation of the widest possible range of stakeholders and studies on the influence of social media. This research is the first to use both image and text analyses to study place brand identity from UGC. The use of both analyses allows the two methods to complement one another while mitigating the weaknesses of each.
Board composition, sustainability committee and corporate social and environmental performance in Australia
Authors: Biswas Pallab Kumar , Mansi Mansi , Pandey Rakesh 
Published: November 2018

PurposeThe purpose of this study is to examine the impacts of board gender composition, board independence and the existence of a board sustainability committee on the corporate social and environmental performance of Australian firms.Design/methodology/approachThe dataset comprises 2,188 Australian Securities Exchange listed firm-year observations (407 individual firms) from 2004 to 2015. The ASSET4 environmental, social and governance database is used to measure corporate social and environmental performance and their sub-dimensions.FindingsOur results show that firms with higher board gender composition, greater board independence and sustainability committees tend to have better social and environmental performance. This paper also provides empirical evidence of the positive association of these variables on the sub-dimensions of social and environmental performance. The results are robust after controlling for self-selection and various forms of endogeneity.Originality/valueThis is the first study that examines the relationship between sustainability committees and corporate social and environmental performance in the context of Australia. This study also overcomes the relatively small sample size and shorter study period issues of similar studies in Australia that provide inconclusive evidence on the relationship between each of board gender composition, board independence and corporate social and environmental performance.
The evolution of social entrepreneurship research: a bibliometric analysis
Authors: Dionisio Marcelo 
Published: November 2018

Purpose
The purpose of this paper is to provide an overview of research on social entrepreneurship through a bibliometric study and the use of Gartner’s (1985) framework to determine the evolution of this academic field.

Design/methodology/approach
The study is based on all conceptual and research papers published in the Social Enterprise Journal, the first publication to exclusively explore the social entrepreneurship field, from 2005 to 2017 and is conducted with the use of the open-source software package R. The work proposes an overview of the field and a deeper investigation through a bibliometric analysis and the use of Gartner’s framework to categorize the field in four dimensions: individual, organization, process and environment.

Findings
This work studied the development of social entrepreneurship as an emergent field, identifying key authors, institutions and their geographic origins, research and data collection methods and the key topics analyzed in each category, according to Gartner’s framework.

Practical implications
This work offers an overview of the status of research in the field and the main topics studied in this emerging field, with the potential to orient researchers to find new topics and possible gaps that needs further investigating.

Originality/value
This paper provides valuable contributions through a bibliometric analysis that is not very explored in the literature. It presents a general structure of the field and details of the main topics studied in this discipline.