bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary cementless stems in septic hip revision: Indications and results
Authors: Cavagnaro Luca , Chiarlone Francesco , Divano Stefano , Capello Andrea Giorgio , Felli Lamberto , Burastero Giorgio 
Published: June 2019

Purpose: The aim of our work is to evaluate results obtained from a cohort of patients affected by periprosthetic joint infection and treated with a primary cementless stem in a two-stage technique framework. Methods: Eighty-four patients were evaluated at a mean follow-up of 37.4 months. The main demographic, surgical, clinical, and radiographic data were recorded. A femoral window for stem removal was performed in 33 patients. Results: Statistically significant improvement was noted for both the Harris Hip score and the Oxford Hip score. Postsurgical complications included thigh pain in three patients, subsidence (>2 mm) in one patient, implant dislocation in two patients, cup revision in one patient, implant revision for septic failure in two patients, and stem revision for varus position in one patient. The stem survivorship rate was 96.3%. There were no significant differences between the groups in which a cortical window was created or not. Conclusion: Femoral stem revision with primary cementless stems is a viable option in selected patients undergoing two-stage hip revision surgery. Correct indication is a cornerstone of good outcome. The use of a cortical window does not affect the final outcome or implant survivorship rate.
BM is preferred over PBSCs in transplantation from an HLA-matched related female donor to a male recipient
Authors: Nakasone Hideki , Kawamura Koji , Yakushijin Kimikazu , Shinohara Akihito , Tanaka Masatsugu , Ohashi Kazuteru , Ota Shuichi , Uchida Naoyuki , Fukuda Takahiro , Nakamae Hirohisa , Matsuoka Ken-ichi , Kanda Junya , Ichinohe Tatsuo , Atsuta Yoshiko , Inamoto Yoshihiro , Seo Sachiko , Kimura Fumihiko , Ogata Masao 
Published: June 2019

Abstract
The use of granulocyte colony-stimulating factor–mobilized peripheral blood stem cells (PBSCs) and sex-mismatched hematopoietic cell transplantation (HCT), especially with female donors and male recipients (FtoM), is known to be associated with an increased risk of chronic graft-versus-host disease (GVHD) compared with transplantation with bone marrow (BM). This raises the question of whether the use of PBSCs in FtoM HCT might affect allogeneic responses, resulting in fatal complications. Using a Japanese transplantation registry database, we analyzed 1132 patients (FtoM, n = 315; MtoF, n = 260; sex-matched, n = 557) with standard-risk diseases who underwent HCT with an HLA-matched related donor without in vivo T-cell depletion between 2013 and 2016. The impact of PBSC vs BM on transplantation outcomes was separately assessed in FtoM, MtoF, and sex-matched HCT. Overall survival (OS) and nonrelapse mortality (NRM) at 2 years post-HCT were significantly worse in patients with PBSCs vs those with BM in FtoM HCT (2-year OS, 76% vs 62%; P = .0084; 2-year NRM, 10% vs 21%; P = .0078); no differences were observed for MtoF or sex-matched HCT. Multivariate analyses confirmed the adverse impact of PBSCs in FtoM HCT (hazard ratio [HR] for OS, 1.91; P = .025; HR for NRM, 3.70; P = .0065). In FtoM HCT, patients with PBSCs frequently experienced fatal GVHD and organ failure. In conclusion, the use of PBSCs in FtoM HCT was associated with an increased risk of NRM in the early phase, resulting in inferior survival. This suggests that, when we use female-related donors for male patients in HCT, BM may result in better outcomes than PBSCs.
Outcome-based providing and commissioning: pathways and standards
Authors: Kingdon David 
Published: June 2019

Aims and methodImplementation of evidence-based psychosocial interventions in accordance with National Institute of Health and Care Excellence guidelines and quality standards has been incomplete. This project involved allocation of adults under mental health services to six guideline categories, completion of a clinician- and patient-rated outcome measure, and individual assessment against clinical standards.ResultsIn the first 3 months of the project, 5048 patients were allocated to a pathway and 3734 (73%) were assessed against at least one of the relevant standards. All were assessed using the Health of the Nation Outcome Scales (91–93% of scales completed) and 1866 (36%) completed the patient-rated outcome measure, DIALOG.Clinical implicationsClinicians will allocate patients to pathways, complete outcome measures and assess against standards, providing data to guide practice, service design and costing of mental health systems with supporting technology to assist data entry and presentation. This has the potential to provide much improved and readily accessible information about individual outcomes and standards for people with mental health problems and those working with them. It could also provide a method for payment for services which directly support good clinical practice.
Advanced Lipoprotein Analysis Shows Atherogenic Lipid Profile That Improves After Metreleptin in Patients with Lipodystrophy
Authors: Kinzer Alexandra B , Shamburek Robert D , Lightbourne Marissa , Muniyappa Ranganath , Brown Rebecca J 
Published: June 2019

AbstractContextPatients with lipodystrophy have dyslipidemia and insulin resistance. Leptin treatment with metreleptin in lipodystrophy decreases insulin resistance and lowers triglycerides without changing high-density lipoprotein. Detailed measurement of lipoprotein particles with nuclear magnetic resonance (NMR) spectroscopy can offer insights into cardiovascular disease (CVD) risk and lipid metabolism beyond a standard lipid panel. We hypothesized that patients with lipodystrophy would have a more atherogenic lipid profile than controls at baseline, which would be ameliorated with metreleptin treatment.ObjectiveTo characterize the lipoprotein profile in patients with lipodystrophy compared with controls and to evaluate effects of metreleptin treatment.Design, Setting, Patients, and InterventionPatients with lipodystrophy (N = 17) were studied before and after metreleptin for 2 weeks and 6 months and compared with 51 insulin-sensitive sex-matched controls.Main Outcome MeasuresLipoprotein profiles were measured by NMR with the LP4 deconvolution algorithm, which reports triglyceride-rich lipoprotein particles (TRLPs), high-density lipoprotein particles (HDLPs), and low-density lipoprotein particles (LDLPs).ResultsPatients with lipodystrophy had elevated large TRLPs and smaller HDLPs and LDLPs compared with controls. Five patients with lipodystrophy had chylomicrons, compared with zero controls. Metreleptin decreased the size and concentration of TRLPs, eliminated chylomicrons in all but one patient, decreased LDLPs, and increased LDLP size. Metreleptin treatment did not have major effects on HDLPs.ConclusionsPatients with lipodystrophy had an atherogenic lipoprotein profile at baseline consistent with elevated CVD risk, which improved after metreleptin treatment. The presence of fasting chylomicrons in a subset of patients with lipodystrophy suggests saturation of chylomicron clearance by lipoprotein lipase.
Ostatnie miesiące życia, proces i ścięcie Karola I Stuarta w opinii prasy angielskiej
Authors: Nortowska Paulina 
Published: June 2019

The Last Months , Trial and Execution of Charles I in the Opinion of the English Press
The aim of this article is to compare different points of view on phenomenon of the trial, conviction and execution of the English (and Scottish) monarch, Charles I. The newsbooks A Perfect diurnall of the passages in Parliament (paper published by Parliament) and Mercurius Pragmaticus, Communicating intelligence from all parts, touching all affaires, designes, humours, and conditions, throughout the kingdome, especially from Westminster and the head‑quartes (newspaper of supporters of King Charles I of England) were analysed and compared. The comparison was made for the years 1647–1649 with a focus on the Second English Civil War. In the case of A Perfect diurnall, the articles published between 3.06.1647 and 7.02.1649 — from the extradition of King Charles I of England to Commissioners to the King’s funeral. The other newsbook, Mercurius Pragmaticus, was published from 14.09.1947 to 1.05.1649. The main focus of this analysis is to show the differences between the two publications in their presentation of the imprisonment, trial and execution of King Charles I.
Rozczarowania i animozje polskich kombatantów w latach 30. XX wieku
Authors: Kasprzycki Remigiusz 
Published: June 2019

Disappointment and Animosities among Polish Combatants in the 1930s
The Polish combatant environment was extremely divided in the 1930s, even among members of the same organisations. This is confirmed by a 1935 report by the Ministry of the Interior. The strongest accusations and assaults were directed against Polish and Jewish legionnaires by the national press — including in the papers Polska Narodowa, Falanga and books like Kazimierz Dołega’s Żydzi w czasie walk o niepodległość Polski. War veterans were supposed to be idols and models for society, particularly youths. The divided combatants were hardly able to live up to those ideals.
The Human Coping Process in the Context of Organizational Change
Authors: Silva Andre Luis , Sachuk Maria Iolanda 
Published: June 2019

This article systematizes an innovative empirical framework that shows how the transformative process of human coping strategies offers an alternative way to understand the contemporary relations established between individuals and contexts of organizational change. Based on the positive psychology movement, this empirical-qualitative study uses in-depth interviews to professionals, who worked for companies acquired by an international financial institution, for which they worked in the Brazilian market. Through a content analysis, researchers interpreted all data. As a result of this research, the article shows how individual employees transform their protection factors (coping and buffer) through defense mechanisms in managing organizational change imposed in the workplace. This study contributes to the fields of organizational psychology and health psychology, as it delves into the processes through which individual and contextual elements can protect workers under organizationally adverse conditions that can affect them negatively.Keywords: Coping strategies, defense mechanisms, organizational change, qualitative research, positive psychology.
MIRADA DE LOS DOCENTES ANTE LAS PROBLEMÁTICAS ESTUDIANTILES EN EL CICLO BÁSICO DE LA CARRERA MEDICINA VETERINARIA
Authors: Fascendini Paola Yanina , Gramaglia Carina , Cignetti Luciana , Galván Stella 
Published: June 2019

Resumen
El objetivo del presente trabajo es socializar la mirada docente en torno a las problemáticas detectadas en la población estudiantil del ciclo básico de la carrera Medicina Veterinaria, a partir del análisis de los factores que desde su perspectiva inciden en el recorrido académico de los estudiantes. La instrumentación de una encuesta diseñada para docentes permitió acercarnos a las interpretaciones que realizan de lo que acontece en este tramo de la carrera, con el fin de tomar conciencia de aquellos factores que tienden a repercutir significativamente en el desempeño de los jóvenes. Los resultados obtenidos nos indican que los docentes observan dificultades vinculadas a la interpretación de las consignas, las cuales son atribuidas principalmente a la escasa preparación que han obtenido en el nivel secundario, así como también a factores emocionales que tienden a impactar en la continuidad de los estudios. A su vez, expresan que la desorientación vocacional resulta ser un signo importante que repercute en la motivación por la carrera elegida. Otros indicadores importantes refieren a la falta de métodos de estudios propios, y a dificultades para la expresión oral y escrita. Además, señalan que las propuestas pedagógicas ofrecidas no siempre satisfacen las necesidades de los estudiantes actuales.
¿Qué pretenden las neurociencias de la educación? Reflexiones sobre posibilidades o separaciones.
Authors: Corvalán Facundo Juan Manuel 
Published: June 2019

Este artículo plantea una discusión conceptual y metodológica entre las Neurociencias y la Educación considerando en el debate el aporte de la perspectiva Histórica-Cultural. Primeramente se define al campo teórico entendido como Neurociencias, seguido a esto se articulan diferentes enfoques en relación a debates educativos. Se reflexiona sobre el papel que se le da al cerebro en los procesos de enseñanza y aprendizaje en posturas que oscilan entre distintos reduccionismos.
El desafío metodológico en las Ciencias de la Educación supone integrar intencionalidades científicas. La explicación y la interpretación aparecen como opciones para lograr una perspectiva que dé cuenta de la naturaleza de las problemáticas complejas. Investigaciones actuales permiten analizar estas alternativas epistemológicas y técnicas.
Son varios los temas que abordan las Neurociencias que plantean vínculos con la Educación, el modo de articulación y las intervenciones posibles dependerá de como se asuman las lógicas implicadas en los conocimientos y en las prácticas. Algunas contradicciones en estas ofertas de ideas demandan un análisis coherente desde los actores del campo de la educación.
ENSEÑANZA DE LAS CIENCIAS MORFOLÓGICAS MEDIADA POR TECNOLOGÍAS EMERGENTES.
Authors: Fabro Ana Patricia 
Published: June 2019

En el marco de la realidad educativa actual, atravesada por la incorporación de tecnologías a las aulas, es necesario reflexionar acerca de los aportes que generan las diferentes propuestas de enseñanza mediadas por estos dispositivos y en torno a los modelos educativos que las sustentan.
Mediante una metodología de investigación combinada, se indagó acerca de la contribución de un ecosistema tecnológico a la enseñanza de las Ciencias Morfológicas. A partir de los resultados obtenidos, se aprecia que su utilización no se limita a la mera innovación de los soportes tecnológicos, sino a una verdadera transformación de la enseñanza.

Palabras clave: Enseñanza-Ciencias Morfológicas-tecnologías emergentes.
“HILANDO HISTORIAS: CONSTRUCCIÓN COLECTIVA DE UN DISPOSITIVO DIDÁCTICO SOBRE EDUCACIÓN ALIMENTARIA NUTRICIONAL”.
Authors: Ravelli Sandra , Oliva Mariana , Oliva Mariana , Rossa Vanesa , Schonborn Adalgisa , Schonborn Adalgisa 
Published: June 2019

La Educación Alimentaria Nutricional resulta una herramienta valiosa y efectiva, para conseguir cambios voluntarios en los hábitos y estilos de vida. Realizarla en edades tempranas es clave para promover hábitos de alimentación saludables que perduren a lo largo de la vida.
Transmitir mensajes en el nivel inicial es un desafío, ya que el aprendizaje debe ser realizado mediante el juego, y con recursos didácticos apropiados. Al respecto, uno de los objetivos de este equipo extensionista fue construir e implementar interdisciplinariamente un dispositivo didáctico, con contenidos de Educación Alimentaria Nutricional para dos Jardines de la ciudad de Santa Fe, Argentina; el Jardín Municipal Coronel Dorrego y el Jardín Nº 68 “Dr. Camilo Corti”.
Este trabajo, de enfoque cualitativo descriptivo, se enmarcó en un Proyecto de Extensión e interés social de la Licenciatura en Nutrición de la Facultad de Bioquímica y Ciencias Biológicas. Se realizó en cuatro etapas; recolección de datos y diagnóstico del caso situado; construcción interdisciplinaria del dispositivo, validación con profesionales idóneos e implementación en las salas entre 0 y 5 años, a través de talleres desarrollados con los niños de los jardines. Los instrumentos utilizados fueron entrevistas, observación, registro de informes y trabajo en equipo, maximizando los cruces interdisciplinares.
La particularidad del enfoque interdisciplinario enriqueció el material construido. La implementación del libro-objeto, resultó una herramienta innovadora para realizar EAN en el nivel inicial, despertando la imaginación y promoviendo el aprendizaje en las primeras etapas de la vida, para contribuir así al desarrollo de hábitos y estilos de vida beneficiosos para la salud.
Ryanodine Receptor 2 Contributes to Impaired Protein Localization in Cyclic Nucleotide-Gated Channel Deficiency
Authors: Ma Hongwei , Yang Fan , Butler Michael R. , Rapp Jacob , Le Yun-Zheng , Ding Xi-Qin 
Published: June 2019

AbstractThe photoreceptor cyclic nucleotide-gated (CNG) channel plays a pivotal role in phototransduction and cellular calcium homeostasis. Mutations in the cone photoreceptor CNG channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophies. CNG channel deficiency leads to endoplasmic reticulum (ER) stress-associated cone apoptosis, protein mislocalization, and ER calcium dysregulation. This work investigated the potential mechanisms of protein mislocalization associated with ER calcium dysregulation usingCnga3-/-mice lacking ER Ca2+channel ryanodine receptor 2 (RyR2) specifically in cones. Deletion ofRyr2improved outer segment (OS) localization of the cone proteins M-opsin, S-opsin, and cone phosphodiesterase subunit α′ (PDE6C) and decreased inner segment localization. One-month-oldCnga3-/-mice showed ∼30% of M-opsin, 55% of S-opsin, and 50% of PDE6C localized to the OS.Cnga3-/-mice withRyr2deletion at the same age showed almost 60% of M-opsin, 70% of S-opsin, and 70% of PDE6C localized to the OS. Deletion ofRyr2nearly completely reversed elevations of the ER stress markers phospho-IRE1α and phospho-eIF2α and suppressed cone apoptosis. Consistent with the improved cone protein localization and reduced ER stress/cone apoptosis, cone survival was improved by deletion ofRyr2. The number of cones was increased by ∼28% in 2- to 4-month-oldCnga3-/-mice withRyr2deletion compared with age-matchedCnga3-/-mice. This work demonstrates a role of RyR2/ER calcium dysregulation in protein mislocalization, ER stress, and cone death. The findings provide novel insights into the mechanisms of photoreceptor degeneration and support strategies targeting ER calcium regulation to manage retinal degeneration.
Razonamiento clínico en terapia ocupacional. Una revisión narrativa
Authors: Moruno-Miralles Pedro , Talavera-Valverde Miguel Ángel , Reyes-Torres Adriana 
Published: June 2019

Introducción. El razonamiento clínico ordena el procesamiento de la información obtenida durante la evaluación, facilitando tomar decisiones para implementar planes de tratamiento. Esta área es cada vez más relevante para la formación de estudiantes y profesionales de terapia ocupacional. Objetivo. Analizar la literatura sobre razonamiento clínico en terapia ocupacional publicada entre 2009 y 2018. Materiales y métodos. Se realizó una revisión de la literatura en bases de datos, repositorios institucionales, monografías y literatura gris de alcance. Se establecieron criterios de selección para la obtención de documentos que luego se analizaron estableciendo un conjunto de variables que permitieron el análisis de la literatura. Resultados. La literatura sobre razonamiento clínico en el período estudiado fue de 99 publicaciones, más de la mitad que en los 33 años anteriores. El razonamiento clínico en el ámbito docente es el de mayor impacto (41.4%); 52.5% son publicaciones que mejoran la práctica con sus aportes al reforzar el desarrollo de destrezas profesionales y la calidad de las intervenciones. Conclusión. El aumento de la investigación sobre razonamiento clínico en terapia ocupacional dota a esta área de conocimiento y rigor, mejorando así la eficacia de los terapeutas ocupacionales.
Perspectivas teóricas para el abordaje de los movimientos sociales y su incorporación en el campo de la investigación en turismo
Authors: Cruz Gonzalo Matías 
Published: June 2019

El presente trabajo explora la literatura producida en el campo de la investigación en turismo que incorpora perspectivas teóricas utilizadas para el abordaje de los movimientos sociales. Esta tarea permite exponer las posibilidades de desarrollo del área en cuestión y presentar instrumentos analíticos novedosos. A partir de una revisión bibliográfica exhaustive se analizan las publicaciones existentes, teniendo en cuenta objetivos, casos de estudio, unidades de análisis, resultados y, especialmente, marcos teóricos y metodológicos adoptados. Se advierte que, a pesar de la diversidad de propuestas de abordaje, se trata de un ámbito de estudio aún incipiente, cuyo desarrollo exige el examen de nuevos casos a partir de una visión que contemple las especificidades de cada problemática y las oportunidades que las distintas Corrientes de pensamiento ofrecen.
Visibilidad en línea: análisis de los hoteles de Tunja (Colombia)
Authors: Arévalo Lizarazo Guillermo Alejandro , Álvarez Burgos María Inés 
Published: June 2019

El turismo es un sector intensivo en información que se ha beneficiado de los avances tecnológicos basados en internet, desde mejoras en la gestión interna hasta la ampliación de los canales de distribución y promoción. La presente investigación tiene como objetivo medir el uso de las tecnologías de información y comunicación por parte de los 75 hoteles legalmente establecidos en la ciudad de Tunja (Colombia), a partir del concepto denominado findability o “visibilidad en internet”. La hipótesis central del estudio es que menos de un 50 % de estas empresas de alojamiento son visibles en redes sociales, agencias de viajes en internet, aplicaciones de mapas, directorio empresarial y blogs más populares. La investigación concluye que el uso de medios digitales por parte del sector hotelero con el fin de lograr visibilidad es bajo para una ciudad que planea posicionarse como destino turístico importante en Colombia, pero da cuenta de la existencia de oportunidades desde la política pública y el sector privado para satisfacer esta necesidad.
Mitigating the Mindless Mouthful Through Moderation, Manipulation, and Mindfulness
Authors: Endicott Lexi , 2018 Class of 
Published: June 2019

The prevalence of global obesity is increasing at an unprecedented rate. Conventional weight loss programs, though logical in theory, usually prove to be ineffective in practice. There is an increased need and urgency for healthcare professionals to develop innovative methods to combat this pernicious health condition. Embracing the concept of mindful eating is one way that individuals can improve the quality of their health and well-being. This paper highlights the definition of mindful eating, describes the consequences of mindless eating, discusses the Japanese concept of hara hachi bu, and finally offers realistic practices that individuals can adopt in order to improve their connection with food and with others.
Eden Zoological Garden
Authors: Wong Brooke , 2018 Class of 
Published: June 2019

Brooke Wong’s project involved the marketing and branding of Eden Zoological Garden. Eden Zoological Garden is a zoo and research center that hosts animals threatened by extinction and assists in repopulating them. This was accomplished through extensive research of zoos, animal extinction, and the correct branding to appeal to a wide age range. In addition, imagery of animals in art throughout history was studied extensively in order to best pay homage to the rich foundations of animal art. The final result included branding, stationery, tickets, collateral, advertising, a website, application, map, infographic, interior design, exhibit design, and way finding.