bluuebunny/crossref_metadata_2025_split huggingface dataset:
The “Fiat 500L” commercial: A journey into Italian style
Authors: Paris Orlando 
Published: May 2019

Abstract
This essay will analyze a single script, the television commercial that advertises the Fiat 500L in the United States, released in 2013. This commercial has stimulated wide debate both in Italy and the United States. It was generally well received by the press, even if it did attract some criticism on the part of those who simply read it as the latest version of a series of stereotypes of Italian mores. Without neglecting the functional dynamic of advertising (narratological structure and underlying rhetorical devices), this analysis will focus in particular on the decisive role played by Italianness and the Italian language.
“May I tell you something?”: When questions do not anticipate responses
Authors: Alvanoudi Angeliki 
Published: May 2019

AbstractThis conversation analytic paper reports on the interactional functions of the Greek subjunctive polar interrogative clausena (su) po (káti)?‘may I tell you something?’ in informal Greek conversation (Corpus of Spoken Greek). It is shown that the clause is a practice for securing a multi-unit turn and prefacing big packages in interaction, such as arguments and tellings. It is argued that the interrogative clause is used as a discourse marker when it occupies the initial slot of an extended turn. By employing an interactional approach to grammar, this study brings sequential context, social action and practice into the analysis of the clausena (su) po (káti)?, and sheds light on the vehicular structure of social action and the emergence of linguistic devices that project multi-unit turns.
The "Double-edged Sword" of Institutional Power: COSATU, Neo-liberalisation and the Right to Strike
Authors: Runciman Carin 
Published: June 2019

On 1 January 2019 amendments to the Labour Relations Act came into force that significantly altered and curtailed the right to protected strike action in South Africa. Internationally, the right to strike has been eroded in recent years with many countries adopting legal provisions that violate the International Labour Organization’s principles. Comparatively, the rights of South African workers to go on protected strikes remain better than many other places in the world, a reflection of the militant history of the South African labour movement. But the erosion of these rights, with the active support of the Congress of South African Trade Unions, should be a cause for concern for activists and labour scholars in South Africa and beyond. This article develops the Power Resources Approach to consider how union institutional power has entrenched neo-liberalism in South Africa. Grounding the analysis of institutional power within the analytical framework of corporatism allows this article to develop an analysis of institutional power that is attentive to class forces. This provides an avenue for understanding the “double-edged sword” of institutional power in the South African context in order to comprehend when and under what circumstances trade unions advance and defend the interests of the working class and when they defend those of capital.
KEY WORDS: labour; neo-liberalism; institutional power; corporatism; South Africa
First-positive surveillance screening in an asymptomatic SDHA germline mutation carrier
Authors: White Gemma , Tufton Nicola , Akker Scott A 
Published: May 2019

Summary
At least 40% of phaeochromocytomas and paraganglioma’s (PPGLs) are associated with an underlying genetic mutation. The understanding of the genetic landscape of these tumours has rapidly evolved, with 18 associated genes now identified. Among these, mutations in the subunits of succinate dehydrogenase complex (SDH) are the most common, causing around half of familial PPGL cases. Occurrence of PPGLs in carriers of SDHB, SDHC and SDHD subunit mutations has been long reported, but it is only recently that variants in the SDHA subunit have been linked to PPGL formation. Previously documented cases have, to our knowledge, only been found in isolated cases where pathogenic SDHA variants were identified retrospectively. We report the case of an asymptomatic suspected carotid body tumour found during surveillance screening in a 72-year-old female who is a known carrier of a germline SDHA pathogenic variant. To our knowledge, this is the first screen that detected PPGL found in a previously identified SDHA pathogenic variant carrier, during surveillance imaging. This finding supports the use of cascade genetic testing and surveillance screening in all carriers of a pathogenic SDHA variant.

Learning points:

SDH mutations are important causes of PPGL disease.

SDHA is much rarer compared to SDHB and SDHD mutations.

Pathogenicity and penetrance are yet to be fully determined in cases of SDHA-related PPGL.

Surveillance screening should be used for SDHA PPGL cases to identify recurrence, metastasis or metachronous disease.

Surveillance screening for SDH-related disease should be performed in identified carriers of a pathogenic SDHA variant.
Parental Refusal of Standard-of-Care Prophylactic Newborn Practices: In One Center’s Experience, Many Refuse One but Few Refuse All
Authors: Danziger Phoebe , Skoczylas Maria , Laventhal Naomi 
Published: May 2019

OBJECTIVES:
Several interventions to reduce neonatal morbidity and mortality are universally recommended: intramuscular (IM) vitamin K (VK), erythromycin ophthalmic prophylaxis, and hepatitis B vaccine for newborns, and maternal pertussis vaccine. Despite robust efficacy and safety evidence, parental refusal of these practices is increasing. We sought to define the current declination rate and characterize the association between declination of 1 intervention and declination of the others.

METHODS:
A retrospective cohort study was performed of all inborn singletons admitted to the well newborn nursery over a 12-month period (November 15, 2015 through November 15, 2016) at a large quaternary center.

RESULTS:
In total, 3758 infants met inclusion criteria. 25% (n = 921) did not receive at least 1 of the 4 interventions. 13.6% (n = 511) did not receive the hepatitis B vaccine, 2.3% (n = 85) did not receive IM VK, 5.9% (n = 223) did not receive erythromycin, and 7.2% (n = 271) of mothers did not receive the prenatal tetanus, diphtheria, pertussis vaccine. Odds of refusal of IM VK were 6.2 times greater for infants delivered by a certified nurse midwife versus physician (95% confidence interval 3.3–11.6). Pattern of declination was variable; of 921 mother-infant dyads who did not receive at least 1 intervention, only 2 dyads received none of the interventions.

CONCLUSIONS:
Our study is one of the first in which patterns of refusal of standard-of-care perinatal practices are characterized. Alarmingly, one-fourth of our cohort did not receive at least 1 core infant health intervention. Our finding of only modest overlap in declination of each intervention carries implications for the development of targeted interventions.
Impact of 21-Gene Breast Cancer Assay on Treatment Decision for Patients with T1–T3, N0–N1, Estrogen Receptor-Positive/Human Epidermal Growth Receptor 2-Negative Breast Cancer: Final Results of the Prospective Multicenter ROXANE Study
Authors: Dieci Maria Vittoria , Guarneri Valentina , Zustovich Fable , Mion Marta , Morandi Paolo , Bria Emilio , Merlini Laura , Bullian Pierluigi , Oliani Cristina , Gori Stefania , Giarratano Tommaso , Orvieto Enrico , Griguolo Gaia , Michieletto Silvia , Saibene Tania , Del Bianco Paola , De Salvo Gian Luca , Conte PierFranco ,   on behalf of the Veneto Oncology Network
Published: May 2019

Abstract

Background
The ROXANE Italian prospective study evaluated the impact of the 21-gene Recurrence Score (RS) results on adjuvant treatment decision for patients with early breast cancer.

Materials and Methods
Nine centers participated. Physicians used the RS test whenever unsure about adjuvant treatment recommendation for patients with estrogen receptor-positive/human epidermal growth receptor 2-negative, T1–T3, N0–N1 early breast cancer. Pre-RS and post-RS treatment recommendations were collected.

Results
A total of 251 patients were included. N0 patients (61%) showed higher grade (p &lt; .001) and higher Ki67 (p = .001) and were more frequently progesterone receptor negative (p = .012) as compared with N1 patients. RS results were as follows: &lt;11, n = 63 (25.1%); 11–25, n = 143 (57%); and ≥26, n = 45 (17.9%). Higher RS was found in N0 vs. N1 patients (p = .001) and in cases of G3 (p &lt; .001) and higher Ki67 (p &lt; .001). The rate of change in treatment decision was 30% (n = 75), mostly from chemotherapy (CT) plus hormone therapy (CT + HT) to hormone therapy (HT; 76%, n = 57/75). The proportion of patients recommended to CT + HT was significantly reduced from pre-RS to post-RS (52% to 36%, p &lt; .0001). CT use reduction was more evident for N1 patients (55% to 27%) than for N0 patients (50% to 42%) and was observed only in cases of RS ≤17.

Conclusion
Physicians predominantly used the 21-gene assay in N0 patients with a more aggressive biology or in N1 patients showing more indolent biology. In this selected patient population, the use of RS testing led to a 30% rate of change in treatment decision. In the N1 patient subgroup, the use of RS testing contributed to reduce CT use by more than half.

Implications for Practice
This study shows that, even in a context in which physicians recommend a high proportion of patients to endocrine treatment alone before knowing the results of the Recurrence Score (RS) assay, the use of the RS test, whenever uncertainty regarding adjuvant treatment recommendation is present, significantly contributes in further reducing the use of chemotherapy, especially for N1 patients.
Safety and Success of Repeat Lung Needle Biopsies in Patients with Epidermal Growth Factor Receptor-Mutant Lung Cancer
Authors: Fintelmann Florian J. , Troschel Fabian M. , Kuklinski Martin W. , McDermott Shaunagh , Petranovic Milena , Digumarthy Subba R. , Sharma Amita , Troschel Amelie S. , Price Melissa C. , Hariri Lida P. , Gilman Matthew D. , Shepard Joanne O. , Sequist Lecia V. , Piotrowska Zofia 
Published: May 2019

Abstract

Background
Postprogression repeat biopsies are critical in caring for patients with lung cancer with epidermal growth factor receptor (EGFR) mutations. However, hesitation about invasive procedures persists. We assessed safety and tissue adequacy for molecular profiling among repeat postprogression percutaneous transthoracic needle aspirations and biopsies (rebiopsies).

Materials and Methods
All lung biopsies performed at our hospital from 2009 to 2017 were reviewed. Complications were classified by Society of Interventional Radiology criteria. Complication rates between rebiopsies in EGFR-mutants and all other lung biopsies (controls) were compared using Fisher's exact test. Success of molecular profiling was recorded.

Results
During the study period, nine thoracic radiologists performed 107 rebiopsies in 75 EGFR-mutant patients and 2,635 lung biopsies in 2,347 patients for other indications. All biopsies were performed with computed tomography guidance, coaxial technique, and rapid on-site pathologic evaluation (ROSE). The default procedure was to take 22-gauge fine-needle aspirates (FNA) followed by 20-gauge tissue cores. Minor complications occurred in 9 (8.4%) rebiopsies and 503 (19.1%; p = .004) controls, including pneumothoraces not requiring chest tube placement (4 [3.7%] vs. 426 [16.2%] in rebiopsies and controls, respectively; p &lt; .001). The only major complication was pneumothorax requiring chest tube placement, occurring in zero rebiopsies and 38 (1.4%; p = .4) controls. Molecular profiling was requested in 96 (90%) rebiopsies and successful in 92/96 (96%).

Conclusion
At our center, repeat lung biopsies for postprogression molecular profiling of EGFR-mutant lung cancers result in fewer complications than typical lung biopsies. Coaxial technique, FNA, ROSE, and multiple 20-gauge tissue cores result in excellent specimen adequacy.

Implications for Practice
Repeat percutaneous transthoracic needle aspirations and biopsies for postprogression molecular profiling of epidermal growth factor receptor (EGFR)-mutant lung cancer are safe in everday clinical practice. Coaxial technique, fine-needle aspirates, rapid on-site pathologic evaluation, and multiple 20-gauge tissue cores result in excellent specimen adequacy. Although liquid biopsies are increasingly used, their sensitivity for analysis of resistant EGFR-mutant lung cancers remains limited. Tissue biopsies remain important in this context, especially because osimertinib is now in the frontline setting and T790M is no longer the major finding of interest on molecular profiling.
Navigating Challenging Conversations About Nonmedical Opioid Use in the Context of Oncology
Authors: Sager Zachary , Childers Julie 
Published: May 2019

Abstract

Opioids are commonly used in the context of oncology to treat cancer-related pain. In the context of increased awareness of nonmedical use of opioids, including misuse and opioid use disorder among individuals with cancer, oncologists may find themselves having difficult conversations with patients regarding the use of opioids. We offer a review of pertinent literature and a conversation framework for providers to use, as well as key communication strategies for clinicians. Building on the therapeutic alliance between provider and patient, emphasizing the importance of nonabandonment, and using a benefit-to-harm framework, we hope clinicians find they are more able to navigate these challenging but important conversations with patients.

Implications for Practice
Providers may find it difficult and uncomfortable to discuss nonmedical use of opioids with patients. To the authors’ knowledge, no previous articles discuss ways to communicate about nonmedical use of opioids in the oncology setting. This work borrows from other specialties and offers a communication framework and key communication strategies to help clinications communicate more effectively with patients who may have an opioid use disorder or may be using their prescribed opioids for reasons other than their pain.
El delito como castigo: las cárceles colombianas
Authors: Moreno Torres Aurora Inés 
Published: June 2019

El objetivo de este estudio es analizar hasta qué punto la cárcel se convierte en un lugar de nuevos aprendizajes delincuenciales, donde la lucha por la supervivencia es un desafío diario y la falta de dinero deja al reo en estado de vulnerabilidad frente a los grupos u organizaciones delictivas que operan dentro del penal. La resocialización a través de una ocupación, el aprendizaje de un oficio y el estudio profesional son modalidades que deben existir en toda cárcel para evitar la reincidencia, para que el castigo resulte una oportunidad para aprender un nuevo oficio y para persuadir contra el delito. Contrario a esto, existe un alto índice de reincidencia y hacinamiento, que impide que el delincuente se aparte del delito. En este artículo se hace un análisis dentro de dos cárceles en Colombia.

Abstract
This article aims to analyze the extent to which the prison becomes a place of new delinquent learning, where the struggle for survival is a daily challenge and the lack of money leaves the prisoner in a vulnerable state in front of groups or criminal organizations who operate inside the prison. The re-socialization through an occupation, learning a trade and professional study are modalities that must exist in every prison to avoid recidivism, for the punishment to become an opportunity to learn a new trade and to persuade against crime. On the contrary, there is a high rate of recidivism and overcrowding, which prevents the offender from separating from the crime. This article presents an analysis inside two prisons in Colombia.
Crimen y castigo. Una reflexión desde América Latina
Authors: Coimbra Luiz Octavio , Briones Álvaro 
Published: June 2019

Este artículo presenta el debate entre dos visiones relativas a la forma de enfrentar el fenómeno criminal. De una parte, aquella que establece que existe en los seres humanos la capacidad de decidir de forma racional su comportamiento y elegir libremente frente a los valores contrastados del delito y su castigo. De otra, la que plantea que el fenómeno delictivo puede tener raíces en situaciones sociales y económicas frente a las cuales es posible actuar corrigiendo anomalías sociales y previniendo el delito antes de que este se cometa. Para la primera de estas visiones, la sanción penal, la cárcel, representa exclusivamente el castigo; para la segunda, es el camino de la rehabilitación y la reinserción social. El artículo muestra que, entre estas dos alternativas, en la mayoría de los países latinoamericanos se ha optado durante las últimas décadas por la primera. En consecuencia, han adoptado políticas públicas de “mano dura”, que enfatizan el castigo por sobre la prevención y la rehabilitación. El artículo busca demostrar que ese camino no ha dado resultados, en relación con el objetivo de disuadir de la conducta delictual. En consecuencia, esa política debe ser modificada.
Abstract
This article presents the debate between two visions regarding ways to confront the criminality. On the one hand, the vision that human beings rationally decide their behavior and choose their options freely when facing the contrasted values ??of crime and punishment. On the other hand, the idea that criminality may have roots in social and economic situations in which it is possible to act by correcting social anomalies and preventing crime. For the first of these visions, the penal sanction, the prison, represents exclusively the punishment; for the second, it is the path of rehabilitation and social reintegration. The article shows that, between these two alternatives, most Latin American countries have opted for the first during the last decades. Consequently, they have adopted “iron-fist” public policies, which emphasize the punishment instead of prevention and rehabilitation. The article seeks to demonstrate that this path has not yielded results in relation to the objective of dissuading delinquent behavior. Consequently, that policy must be modified.
Vecinos en alerta: un rol difícil de institucionalizar. Estudio en la Ciudad de Buenos Aires
Authors: Dikenstein Violeta 
Published: June 2019

En este artículo nos proponemos analizar la actividad de un conjunto de actores, residentes de un barrio del sur de la ciudad de Buenos Aires, que hacen de la inseguridad su ámbito de intervención, de ejercicio y de “trabajo”, a quienes denominamos –provisoriamente– vecinos en alerta. Desde una perspectiva cualitativa basada en la realización de entrevistas en profundidad con los actores implicados en el proceso estudiado y observación participante en los múltiples escenarios por donde circulan, reconstruimos los perfiles de los vecinos en alerta, el repertorio de actividades que llevan adelante, las relaciones que establecen entre sí y con otros actores, los lazos de coordinación y conflicto que entablan en este transcurso, así como las situaciones de interacción en las que este rol entra en juego. Hallamos que hay un repertorio compartido de actividades que desempeñan estos actores, variado dentro de ciertos límites. También, que el rol de vecino en alerta está sujeto a una constante negociación y redefinición, en las instancias de encuentro con diversas autoridades institucionales encargadas de la seguridad.
Abstract
In this article we propose to analyze the activity of a group of people, residents of a neighborhood in the south of the city of Buenos Aires, who make insecurity their area of intervention, exercise and "work", whom we call alert neighbors. From a qualitative perspective based on in-depth interviews with those involved in the process studied, and participatory observation in the scenarios where they circulate, we describe the profiles of the alert neighbors, the repertoire of activities that they carry out, the relationships they establish among themselves and with other actors, the bonds of coordination and conflict that they establish in this course, as well as the situations of interaction in which this role comes into play. We find that there is a shared repertoire of activities performed by these actors, varied within certain limits. Also, that the role of alert neighbor is subject to constant negotiation and redefinition, in the instances of meeting with various institutional authorities in charge of security.
Modelo de gestión de inventario para reducir los costos logísticos de materia prima en la empresa ARY Servicios Generales S. A. C.; 2017
Authors: Ventura Rodriguez Josselin Del Pilar , Benites Aliaga Alex Antenor , Benites Aliaga Ricardo Steiman 
Published: June 2019

La presente tesis buscó desarrollar un modelo de gestión de inventarios para reducir los costos logísticos dentro de la empresa ARY Servicios Generales S.A.C de la ciudad de Trujillo a través de la aplicación del modelo de inventario de revisión periódica puesto que hoy en día lo que toda empresa busca satisfacer al cliente, pero cuidando sus costos internos. El estudio se aplicó al inventario de materia prima conformado por 40 materiales para producir 10 productos del segmento A. Realizándose un estudio de diseño pre experimental trabajando de manera retrospectiva con la demanda histórica obteniendo con el modelo propuesto una reducción de los costos logísticos de S/. 6,341.61 soles anuales (2.39%). Resultados que fueron analizados estadísticamente con la prueba de wilcoxon con un valor P menor a 0.05 al presentar la diferencia de los costos logísticos un comportamiento no normal. Con lo cual se concluye que el desarrollo de un modelo de gestión de inventario como en este caso el modelo de revisión periódica permitió disminuir los costos logísticos en un porcentaje significativo, lo cual es óptimo para la empresa en estudio.
Palabras Clave: Gestión de inventarios de revisión periódica, Costo de almacenamiento.
ISLAMIC MODERATION (WASATIYYAH) MANIFESTATION OF PRACTICES: AN ELABORATION OF ITS DEGREE OF EFFECTIVENESS
Authors: Hj. Yaakub Muhamadul Bakir , Othman Khatijah , Nik Nazli Nik Nadian 
Published: June 2019

Purpose: The study is an attempt to elaborate on students' development explicitly, understanding and practices of Islamic Moderation Personality (IMP) in Malaysian Higher Learning Institution (MHLI). The measurement of the development of their understanding, especially in term of its representation of IMP is underlined. Based on this measurement, personal conceptual beliefs, understanding principles in life and the manifestation of IMP able to make a person different compared to others. In this article, the cause of differences is measured by comparing the intensity of IM practices and the manifestation types and patterns.
Methodology: The method used in this study is a quantitative methodology, and by using the questionnaires, the survey has been conducted to 508 respondents in six MHLIs. The data analysis was performed using Structural Equation Modelling (SEM) method with the help of AMOS software version 23.
Results: The survey administered to the students of MHLI showed a higher level of IMP manifestation expressed by their self-conceptual understanding and attitudinal paradigm through attitude to Allah SWT, attitude to own-self, and attitude to others. These strongly contributed to self-satisfaction personality in achieving awareness, perfection, and reasonable state of balanced and robust willingness. Simultaneously, item practices acted as a mediator between Islamic moderation conceptual paradigm and its manifestation practices.
Implications: The finding provides a foundation for further research in IMP manifestation, both as a general principle in life and specific domains such as religion, education, and socialization practices.Hence, IM as a complete balanced system in life should be adopted and practiced accurately and precisely according to the revelation sources.