bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of reducing frame rate from 7.5 to 4 frames per second on radiation exposure in transcatheter atrial septal defect closure
Authors: Boudjemline Younes 
Published: July 2018

AbstractObjectivesThe aim of this study was to evaluate the reduction of frame rate from 7.5 to 4 frames per second on radiation exposure and to provide new standards of radiation exposure.BackgroundFrame rate is a large contributor to radiation exposure. The use of 4 frames per second for closure of atrial septal defects has been reported not to affect the level of radiation exposure.MethodsWe retrospectively reviewed radiation data from all patients referred to our catheterisation laboratory for closure of an atrial septal defect between January, 2015 and June, 2017. Fluoroscopic time, dose area product (μGy.m2), and total air kerma (mGy) were collected. These values were compared according to the frame rate used for closure of atrial septal defects.ResultsA total of 49 atrial septal defects were closed using 7.5 frames per second and 85 using 4 frames per second. Baseline characteristics were similar in both groups. Procedural success was similar in both groups (100 versus 98.8%). Median total air kerma and dose area product were statistically lower in the 4 frames per second group (4 versus 1.3 mGy [p=0.00012]), 43.7 versus 13.1 μGy.m2 [p<0.00001]). There was no increase in median procedure and fluoroscopic times (respectively, 10 and 1.1 min for 7.5 and 4 frames per second), or complications (4.1 versus 2.3%, p>0.05).ConclusionReduction of frame rate allows reducing significantly the radiation exposure while maintaining excellent clinical results in transcatheter closure of atrial septal defects. We recommend implementing this little change in every laboratory in order to achieve drastic reduction of radiation exposure to the patients and laboratory personnel.
Transcatheter closure of ventricular septal defect with two different devices
Authors: Atik Sezen U. , Saltik Levent 
Published: July 2018

AbstractTranscatheter closure of a multi-hole perimembranous ventricular septal defect with an aneurysm is challenging. Specific ventricular septal defect closure devices have been developed, but some occluders are reportedly used in an off-label manner. This report describes a child who had a multi-hole perimembranous ventricular septal defect with an aneurysm and underwent successful transcatheter closure using two different occluders: the Occlutech Duct Occluder (Occlutech, Helsingborg, Sweden) and the Amplatzer Duct Occluder II (St. Jude Medical, Saint Paul, Minnesota, United States of America). Transcatheter closure of a multi-hole perimembranous ventricular septal defect with an aneurysm using these two different devices can be performed safely by an experienced interventionist in selected patients.
Political Turbulence and Stalemate in Contemporary Malaysia: Oligarchic Reconstitutions and Insecurities
Authors: Khoo Boo Teik 
Published: July 2018

AbstractMalaysian politics has been turbulent over the past two decades, as seen in the damaged tradition of leadership transition, non-violent revolts against successive regimes, and unstable realignments of opposing forces. Two startling symptoms point to disorder. One is the heavy electoral losses and loss of legitimacy suffered by the post-Mahathir regimes. The other is the political re-entry of Anwar Ibrahim and Mahathir Mohamad. The persisting turbulence raises certain questions. Why has the ruling party, the United Malays National Organization, been susceptible to internal fighting, being at once a source of hegemonic stability and systemic instability? Why has the apex of the United Malays National Organization repeatedly jeopardised its traditions of leadership succession? Why has one leader, Mahathir Mohamad, been involved in all the disputes? How did the crisis of the party, not just the regime, become intimately tied to economic crisis? Conventional paradigmatic explanations of Malaysian politics – inter-ethnic rivalry in a plural society, elite solidarity, and regime type (semi-democratic, hybrid, or competitive authoritarian) – are of little help even if ethnicity, elite conduct, and authoritarian rule are relevant. Instead, this essay suggests that the turbulence is part of a long trajectory of oligarchic reconstitution bound to a peculiar nexus of state, ethnicity, and class. The paper does not construct a theory of Malaysian politics. It offers a historically informed exploration of a leitmotif of an unfinished project that runs through much of the past 20 years of political conflict and struggle.
Injury Criteria Associated with Soybean Exposure to Dicamba
Authors: Foster Matthew R. , Griffin James L. 
Published: July 2018

AbstractResearch conducted in the field identified 14 injury criteria associated with dicamba (Clarity® diglycolamine salt) applied at 0.6 to 280 g ae ha–1(1/1,000 to 1/2 of 560 g ha–1use rate) to indeterminate soybean at V3/V4 or R1/R2. For each criterion, injury was rated using a scale of 0=no injury, 1=slight, 2=slight to moderate, 3=moderate, 4=moderate to severe, and 5=severe. Greatest crop injury 15 d after treatment (DAT) was observed for dicamba rates of 0.6 to 4.4 g ha–1for upper canopy pale leaf margins (3.8 to 4.2) at V3/V4 and for terminal leaf cupping (4.1 to 5.0) at R1/R2, and for rates of 0.6 to 8.8 g ha–1for upper canopy leaf cupping (3.8 to 4.8) and upper canopy leaf surface crinkling (3.4 to 4.4) at V3/V4. Injury 15 DAT was equivalent to the nontreated control for dicamba rates as high as 4.4 g ha–1for lower stem base swelling at V3/V4 and for upper canopy leaf rollover/inversion and terminal leaf necrosis at R1/R2; for rates as high as 8.8 g ha–1for leaf petiole base swelling and stem epinasty at R1/R2, and lower stem base lesions/cracking (V3/V4 and R1/R2 average); and for rates as high as 17.5 g ha–1for lower leaf soil contact at V3/V4 and leaf petiole droop at R1/R2. The response to increasing dicamba rate observed for the injury criteria was in contrast to the steady increase in visual injury and plant height reduction rated as 0 to 100%. The moderate to severe upper canopy leaf cupping, pale leaf margins, and leaf surface crinkling, and terminal leaf cupping 15 DAT with dicamba at 0.6 to 4.4 g ha–1corresponded to soybean yield loss of 1% to 9% for application at V3/V4 and 2% to 17% at R1/R2.
A New Method of Three‐Dimensional Location for Low‐Frequency Electric Field Detection Array
Authors: Fan X. P. , Zhang Y. J. , Zheng D. , Zhang Y. , Lyu W. T. , Liu H. Y. , Xu L. T. 
Published: July 2018

AbstractWe introduce the empirical mode decomposition algorithm and applied low‐frequency filtering and high‐frequency noise reduction to the waveform of the electric field changes recorded in 1‐ms segments. This algorithm greatly improved the accuracy of the peak time extraction and the number of pulses in the low and very low frequency band, which enhanced the accuracy in positioning the pulse of the electric field change. Compared with the previous algorithm, the algorithm can significantly reduce the time error, giving a better positioning result. With a time error estimate of 100 ns and a limit of goodness of fit less than 5, the number of pulse locations is increased by nearly 7 times. The goodness‐of‐fit distribution of the pulse location results had a normal distribution, and the 95% confidence interval of goodness of fit was 0–4; the corresponding positioning space error was <60 m. The continuity of the lightning channel was significantly improved, and the development characteristics and fine structure of the lightning channel were clearly distinguished. The low‐frequency electric field detection array system gave detailed positioning results for a bolt from the blue lightning strike. By comparing the results from the low‐frequency electric field detection array with the actual lightning strike point, we objectively demonstrated the positioning performance of the new algorithm. The system gave positioning results for the lightning for all seven return strokes. The maximum horizontal distance between the locating point and the real lightning strike point was 57 m, the minimum horizontal distance between them was 3 m, and the mean distance was 27 m.
Dynamic anticrack propagation in snow
Authors: Gaume J. , Gast T. , Teran J. , van Herwijnen A. , Jiang C. 
Published: July 2018

AbstractContinuum numerical modeling of dynamic crack propagation has been a great challenge over the past decade. This is particularly the case for anticracks in porous materials, as reported in sedimentary rocks, deep earthquakes, landslides, and snow avalanches, as material inter-penetration further complicates the problem. Here, on the basis of a new elastoplasticity model for porous cohesive materials and a large strain hybrid Eulerian–Lagrangian numerical method, we accurately reproduced the onset and propagation dynamics of anticracks observed in snow fracture experiments. The key ingredient consists of a modified strain-softening plastic flow rule that captures the complexity of porous materials under mixed-mode loading accounting for the interplay between cohesion loss and volumetric collapse. Our unified model represents a significant step forward as it simulates solid-fluid phase transitions in geomaterials which is of paramount importance to mitigate and forecast gravitational hazards.
A Zika virus vaccine expressing premembrane-envelope-NS1 polyprotein
Authors: Li Anzhong , Yu Jingyou , Lu Mijia , Ma Yuanmei , Attia Zayed , Shan Chao , Xue Miaoge , Liang Xueya , Craig Kelsey , Makadiya Nirajkumar , He Jennifer J. , Jennings Ryan , Shi Pei-Yong , Peeples Mark E. , Liu Shan-Lu , Boyaka Prosper N. , Li Jianrong 
Published: July 2018

AbstractCurrent efforts to develop Zika virus (ZIKV) subunit vaccines have been focused on pre-membrane (prM) and envelope (E) proteins, but the role of NS1 in ZIKV-specific immune response and protection is poorly understood. Here, we develop an attenuated recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing ZIKV prM-E-NS1 as a polyprotein. This vectored vaccine candidate is attenuated in mice, where a single immunization induces ZIKV-specific antibody and T cell immune responses that provide protection against ZIKV challenge. Co-expression of prM, E, and NS1 induces significantly higher levels of Th2 and Th17 cytokine responses than prM-E. In addition, NS1 alone is capable of conferring partial protection against ZIKV infection in mice even though it does not induce neutralizing antibodies. These results demonstrate that attenuated rVSV co-expressing prM, E, and NS1 is a promising vaccine candidate for protection against ZIKV infection and highlights an important role for NS1 in ZIKV-specific cellular immune responses.
Genomic instability in mutant p53 cancer cells upon entotic engulfment
Authors: Mackay Hannah L. , Moore David , Hall Callum , Birkbak Nicolai J. , Jamal-Hanjani Mariam , Karim Saadia A. , Phatak Vinaya M. , Piñon Lucia , Morton Jennifer P. , Swanton Charles , Le Quesne John , Muller Patricia A. J. 
Published: July 2018

AbstractCell-in-cell (CIC) structures are commonly seen in tumours. Their biological significance remains unclear, although they have been associated with more aggressive tumours. Here we report that mutant p53 promotes CIC via live cell engulfment. Engulfed cells physically interfere in cell divisions of host cells and for cells without p53 this leads to host cell death. In contrast, mutant p53 host cells survive, display aberrant divisions, multinucleation and tripolar mitoses. In xenograft studies, CIC-rich p53 mutant/null co-cultures show enhanced tumour growth. Furthermore, our results show that CIC is common within lung adenocarcinomas, is an independent predictor of poor outcome and disease recurrence, is associated with mutant p53 expression and correlated to measures of heterogeneity and genomic instability. These findings suggest that pro-tumorigenic entotic engulfment activity is associated with mutant p53 expression, and the two combined are a key factor in genomic instability.
Locomotor recovery following contusive spinal cord injury does not require oligodendrocyte remyelination
Authors: Duncan Greg J. , Manesh Sohrab B. , Hilton Brett J. , Assinck Peggy , Liu Jie , Moulson Aaron , Plemel Jason R. , Tetzlaff Wolfram 
Published: July 2018

AbstractRemyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor cells (OPCs) in mice prior to SCI. While OPC proliferation and density are not altered by Myrf inducible knockout after SCI, the accumulation of new oligodendrocytes is largely prevented. This greatly inhibits myelin regeneration, resulting in a 44% reduction in myelinated axons at the lesion epicenter. However, spontaneous locomotor recovery after SCI is not altered by remyelination failure. In controls with functional MYRF, locomotor recovery precedes the onset of most oligodendrocyte myelin regeneration. Collectively, these data demonstrate that MYRF expression in PDGFRα-positive cell derived oligodendrocytes is indispensable for myelin regeneration following contusive SCI but that oligodendrocyte remyelination is not required for spontaneous recovery of stepping.
Highly sensitive switching of solid-state luminescence by controlling intersystem crossing
Authors: Zhao Weijun , He Zikai , Peng Qian , Lam Jacky W. Y. , Ma Huili , Qiu Zijie , Chen Yuncong , Zhao Zheng , Shuai Zhigang , Dong Yongqiang , Tang Ben Zhong 
Published: July 2018

AbstractThe development of intelligent materials, in particular those showing the highly sensitive mechanoresponsive luminescence (MRL), is desirable but challenging. Here we report a design strategy for constructing high performance On–Off MRL materials by introducing nitrophenyl groups to molecules with aggregation-induced emission (AIE) characteristic. The on–off methodology employed is based on the control of the intersystem crossing (ISC) process. Experimental and theoretical investigations reveal that the nitrophenyl group effectively opens the nonradiative ISC channel to impart the high sensitivity and contrast On–Off behavior. On the other hand, the twisted AIE luminogen core endows enhanced reversibility and reduces the pressure required for the luminescence switching. Thin films can be readily fabricated from the designed materials to allow versatile applications in optical information recording and haptic sensing. The proposed design strategy thus provides a big step to expand the scope of the unique On–Off MRL family.
Generating high-order optical and spin harmonics from ferromagnetic monolayers
Authors: Zhang G. P. , Si M. S. , Murakami M. , Bai Y. H. , George Thomas F. 
Published: July 2018

AbstractHigh-order harmonic generation (HHG) in solids has entered a new phase of intensive research, with envisioned band-structure mapping on an ultrashort time scale. This partly benefits from a flurry of new HHG materials discovered, but so far has missed an important group. HHG in magnetic materials should have profound impact on future magnetic storage technology advances. Here we introduce and demonstrate HHG in ferromagnetic monolayers. We find that HHG carries spin information and sensitively depends on the relativistic spin–orbit coupling; and if they are dispersed into the crystal momentum k space, harmonics originating from real transitions can be k-resolved and carry the band structure information. Geometrically, the HHG signal is sensitive to spatial orientations of monolayers. Different from the optical counterpart, the spin HHG, though probably weak, only appears at even orders, a consequence of SU(2) symmetry. Our findings open an unexplored frontier—magneto-high-order harmonic generation.
Ultra-subwavelength thickness for dual/triple-band metamaterial absorber at very low frequency
Authors: Khuyen Bui Xuan , Tung Bui Son , Kim Young Ju , Hwang Ji Sub , Kim Ki Won , Rhee Joo Yull , Lam Vu Dinh , Kim Yong Hwan , Lee YoungPak 
Published: July 2018

AbstractAn integrated model utilizing external parasitic capacitors for a dual-band metamaterial perfect absorber (DMPA) is proposed and demonstrated in the UHF radio band. By adjusting the lumped capacitors on a simple meta-surface, the thickness of absorber is reduced to be only 1/378 and 1/320 with respect to the operating wavelength at 305 and 360.5 MHz, respectively. The simulations and the experiments confirm that the DMPA can maintain an absorption over 91% in a wide range of incident angle (up to 55°) and independent of the polarization of incident radiation. Additionally, we examine the integrated model for smaller dual-band absorber and absorption performance at higher frequencies (LTE band). Finally, we consolidate our approach by fabricating an ultrathin triple-band perfect absorber miniaturized to be only 1/591 of the longest operating wavelength. Our work is expected to contribute to the actualization of metamaterial-based devices working at radio frequency.
Mitochondrial genomes reveal an east to west cline of steppe ancestry in Corded Ware populations
Authors: Juras Anna , Chyleński Maciej , Ehler Edvard , Malmström Helena , Żurkiewicz Danuta , Włodarczak Piotr , Wilk Stanisław , Peška Jaroslav , Fojtík Pavel , Králík Miroslav , Libera Jerzy , Bagińska Jolanta , Tunia Krzysztof , Klochko Viktor I. , Dabert Miroslawa , Jakobsson Mattias , Kośko Aleksander 
Published: July 2018

AbstractFrom around 4,000 to 2,000 BC the forest-steppe north-western Pontic region was occupied by people who shared a nomadic lifestyle, pastoral economy and barrow burial rituals. It has been shown that these groups, especially those associated with the Yamnaya culture, played an important role in shaping the gene pool of Bronze Age Europeans, which extends into present-day patterns of genetic variation in Europe. Although the genetic impact of these migrations from the forest-steppe Pontic region into central Europe have previously been addressed in several studies, the contribution of mitochondrial lineages to the people associated with the Corded Ware culture in the eastern part of the North European Plain remains contentious. In this study, we present mitochondrial genomes from 23 Late Eneolithic and Bronze Age individuals, including representatives of the north-western Pontic region and the Corded Ware culture from the eastern part of the North European Plain. We identified, for the first time in ancient populations, the rare mitochondrial haplogroup X4 in two Bronze Age Catacomb culture-associated individuals. Genetic similarity analyses show close maternal genetic affinities between populations associated with both eastern and Baltic Corded Ware culture, and the Yamnaya horizon, in contrast to larger genetic differentiation between populations associated with western Corded Ware culture and the Yamnaya horizon. This indicates that females with steppe ancestry contributed to the formation of populations associated with the eastern Corded Ware culture while more local people, likely of Neolithic farmer ancestry, contributed to the formation of populations associated with western Corded Ware culture.
Olfactory-cued navigation in shearwaters: linking movement patterns to mechanisms
Authors: Abolaffio Milo , Reynolds Andy M. , Cecere Jacopo G. , Paiva Vitor H. , Focardi Stefano 
Published: July 2018

AbstractAfter foraging in the open ocean pelagic birds can pinpoint their breeding colonies, located on remote islands in visually featureless seascapes. This remarkable ability to navigate over vast distances has been attributed to the birds being able to learn an olfactory map on the basis of wind-borne odors. Odor-cued navigation has been linked mechanistically to displacements with exponentially-truncated power-law distributions. Such distributions were previously identified in three species of Atlantic and Mediterranean shearwaters but crucially it has not been demonstrated that these distributions are wind-speed dependent, as expected if navigation was olfactory-cued. Here we show that the distributions are wind-speed dependent, in accordance with theoretical expectations. We thereby link movement patterns to underlying generative mechanisms. Our novel analysis is consistent with the results of more traditional, non-mathematical, invasive methods and thereby provides independent evidence for olfactory-cued navigation in wild birds. Our non-invasive diagnostic tool can be applied across taxa, potentially allowing for the assessment of its pervasiveness.
Stability of graph theoretical measures in structural brain networks in Alzheimer’s disease
Authors: Mårtensson Gustav , Pereira Joana B. , Mecocci Patrizia , Vellas Bruno , Tsolaki Magda , Kłoszewska Iwona , Soininen Hilkka , Lovestone Simon , Simmons Andrew , Volpe Giovanni , Westman Eric 
Published: July 2018

AbstractGraph analysis has become a popular approach to study structural brain networks in neurodegenerative disorders such as Alzheimer’s disease (AD). However, reported results across similar studies are often not consistent. In this paper we investigated the stability of the graph analysis measures clustering, path length, global efficiency and transitivity in a cohort of AD (N = 293) and control subjects (N = 293). More specifically, we studied the effect that group size and composition, choice of neuroanatomical atlas, and choice of cortical measure (thickness or volume) have on binary and weighted network properties and relate them to the magnitude of the differences between groups of AD and control subjects. Our results showed that specific group composition heavily influenced the network properties, particularly for groups with less than 150 subjects. Weighted measures generally required fewer subjects to stabilize and all assessed measures showed robust significant differences, consistent across atlases and cortical measures. However, all these measures were driven by the average correlation strength, which implies a limitation of capturing more complex features in weighted networks. In binary graphs, significant differences were only found in the global efficiency and transitivity measures when using cortical thickness measures to define edges. The findings were consistent across the two atlases, but no differences were found when using cortical volumes. Our findings merits future investigations of weighted brain networks and suggest that cortical thickness measures should be preferred in future AD studies if using binary networks. Further, studying cortical networks in small cohorts should be complemented by analyzing smaller, subsampled groups to reduce the risk that findings are spurious.