bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anemia and iron deficiency among chronic kidney disease Stages 3–5ND patients in the Chronic Kidney Disease Outcomes and Practice Patterns Study: often unmeasured, variably treated
Authors: Wong Michelle M Y , Tu Charlotte , Li Yun , Perlman Rachel L , Pecoits-Filho Roberto , Lopes Antonio A , Narita Ichiei , Reichel Helmut , Port Friedrich K , Sukul Nidhi , Stengel Benedicte , Robinson Bruce M , Massy Ziad A , Pisoni Ronald L ,   the CKDopps Investigators, Combe Christian , Jacquelinet Christian , Ayav Carole , Briançon Serge , Fouque Denis , Frimat Luc , Laville Maurice , Pascal Christophe , Herpe Yves-Edouard , Lange Céline , Legrans Karine , Liabeuf Sophie , Metzger Marie , Speyer Elodie , Combe Christian , Jacquelinet Christian , Ayav Carole , Briançon Serge , Fouque Denis , Frimat Luc , Laville Maurice , Pascal Christophe , Herpe Yves-Edouard , Lange Céline , Legrans Karine , Liabeuf Sophie , Metzger Marie , Speyer Elodie 
Published: July 2019

Abstract

Background
International variation in anemia assessment and management practices in chronic kidney disease (CKD) is poorly understood.

Methods
We performed a cross-sectional analysis of anemia laboratory monitoring, prevalence and management in the prospective Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps). A total of 6766 participants with CKD Stages 3a–5ND from nephrology clinics in Brazil, France, Germany and the USA were included.

Results
Among patients with anemia (hemoglobin &lt;12 g/dL), 36–58% in Brazil, the USA and Germany had repeat hemoglobin measured and 40–61% had iron indices measured within 3 months of the index hemoglobin measurement. Anemia was more common in the USA and Brazil than in France and Germany across CKD stages. Higher ferritin and lower iron saturation (TSAT) levels were observed with lower hemoglobin levels, and higher ferritin with more advanced CKD. The proportion of anemic patients with ferritin &lt;100 ng/mL or TSAT &lt;20% ranged from 42% in Brazil to 53% in France and Germany, and of these patients, over 40% in Brazil, Germany and the USA, compared with 27% in France, were treated with oral or intravenous iron within 3 months after hemoglobin measurement. The proportion of patients with hemoglobin &lt;10 g/dL treated with erythropoiesis-stimulating agents ranged from 28% in the USA to 57% in Germany.

Conclusions
Hemoglobin and iron stores are measured less frequently than per guidelines. Among all regions, there was a substantial proportion of anemic patients with iron deficiency who were not treated with iron, highlighting an area for practice improvement in CKD care.
Podocyte and tubular involvement in AngioJet-induced kidney injury
Authors: Esteras Raquel , Cannata-Ortiz Pablo , Palacio-Tamarit Marta del , Guerrero-Hue Melania , García-Caballero Cristina , Egido Jesús , Gimeno Javier , Ortiz Alberto , Gracia-Iguacel Carolina , Moreno Juan Antonio 
Published: July 2019

Abstract
The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygenase-1, suggestive of an adaptive response to oxidative stress. This confirms that Hb is involved in kidney cell injury and supports the existence of several different kidney cellular targets.
The age of randomized clinical trials: three important aspects of randomized clinical trials in cardiovascular pharmacotherapy with examples from lipid and diabetes trials
Authors: Drexel Heinz , Rosano Giuseppe M C , Lewis Basil S , Huber Kurt , Vonbank Alexander , Dopheide Jörn F , Mader Arthur , Niessner Alexander , Savarese Gianluigi , Wassmann Sven , Agewall Stefan 
Published: July 2019

Abstract
Randomized clinical trials (RCTs) are important and the Gold Standard for drugs in modern cardiovascular (CV) therapy. The cornerstone of RCTs is the recording of hard clinical endpoints instead of surrogates. It is important to select an appropriate endpoint. Efficacy endpoints must be clinically relevant and can be hierarchically divided. A very interesting innovation in endpoint acquisition is the total event paradigm.
Autism and psychosis as diametrical disorders of embodiment
Authors: Crespi Bernard , Dinsdale Natalie 
Published: July 2019

Abstract
Humans have evolved an elaborate system of self-consciousness, self-identity, self-agency, and self-embodiment that is grounded in specific neurological structures including an expanded insula. Instantiation of the bodily self has been most-extensively studied via the ‘rubber hand illusion’, whereby parallel stimulation of a hidden true hand, and a viewed false hand, leads to the felt belief that the false hand is one’s own. Autism and schizophrenia have both long been regarded as conditions centrally involving altered development of the self, but they have yet to be compared directly with regard to the self and embodiment. Here we synthesize the embodied cognition literature for these and related conditions, and describe evidence that these two sets of disorders exhibit opposite susceptibilities from typical individuals to the rubber hand illusion: reduced on the autism spectrum and increased in schizophrenia and other psychotic-affective conditions. Moreover, the opposite illusion effects are mediated by a consilient set of associated phenomena, including empathy, interoception, anorexia risk and phenotypes, and patterns of genetic correlation. Taken together, these findings: (1) support the diametric model of autism and psychotic-affective disorders, (2) implicate the adaptive human system of self-embodiment, and its neural bases, in neurodevelopmental disorders, and suggest new therapies, and (3) experimentally-ground bayesian predictive coding models with regard to autism compared to psychosis.
Microbial communities in a dynamic in vitro model for the human ileum resemble the human ileal microbiota
Authors: Stolaki Maria , Minekus Mans , Venema Koen , Lahti Leo , Smid Eddy J , Kleerebezem Michiel , Zoetendal Erwin G 
Published: July 2019

ABSTRACTThe important role for the human small intestinal microbiota in health and disease has been widely acknowledged. However, the difficulties encountered in accessing the small intestine in a non-invasive way in healthy subjects have limited the possibilities to study its microbiota. In this study, a dynamic in vitro model that simulates the human ileum was developed, including its microbiota. Ileostomy effluent and fecal inocula were employed to cultivate microbial communities within the in vitro model. Microbial stability was repetitively achieved after 10 days of model operation with bacterial concentrations reaching on average 107 to 108 16S rRNA copy numbers/ml. High diversities similar to those observed in in vivo ileum samples were achieved at steady state using both fecal and ileostomy effluent inocula. Functional stability based on Short Chain Fatty Acid concentrations was reached after 10 days of operation using fecal inocula, but was not reached with ileostomy effluent as inoculum. Principal Components and cluster analysis of the phylogenetic profiles revealed that in vitro samples at steady state clustered closest to two samples obtained from the terminal ileum of healthy individuals, independent of the inoculum used, demonstrating that the in vitro microbiota at steady state resembles that of the human ileum.
The Power of Mantis Shrimp Strikes: Interdisciplinary Impacts of an Extreme Cascade of Energy Release
Authors: Patek S N 
Published: July 2019

AbstractIn the course of a single raptorial strike by a mantis shrimp (Stomatopoda), the stages of energy release span six to seven orders of magnitude of duration. To achieve their mechanical feats of striking at the outer limits of speeds, accelerations, and impacts among organisms, they use a mechanism that exemplifies a cascade of energy release—beginning with a slow and forceful, spring-loading muscle contraction that lasts for hundreds of milliseconds and ending with implosions of cavitation bubbles that occur in nanoseconds. Mantis shrimp use an elastic mechanism built of exoskeleton and controlled with a latching mechanism. Inspired by both their mechanical capabilities and evolutionary diversity, research on mantis shrimp strikes has provided interdisciplinary and fundamental insights to the fields of elastic mechanisms, fluid dynamics, evolutionary dynamics, contest dynamics, the physics of fast, small systems, and the rapidly-expanding field of bioinspired materials science. Even with these myriad connections, numerous discoveries await, especially in the arena of energy flow through materials actuating and controlling fast, impact fracture resistant systems.
Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight
Authors: Hwang Liang-Dar , Lawlor Deborah A , Freathy Rachel M , Evans David M , Warrington Nicole M 
Published: July 2019

AbstractBackgroundThe intrauterine environment is critical for fetal growth and development. However, observational associations between maternal gestational lipid concentrations and offspring birth weight (BW) have been inconsistent and ascertaining causality is challenging.MethodsWe used a novel two-sample Mendelian randomization (MR) approach to estimate the causal effect of maternal gestational high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglyceride concentrations on offspring BW. Single nucleotide polymorphisms (SNPs) associated with serum HDL-C, LDL-C and triglyceride concentrations identified in the Global Lipids Genetics Consortium genome-wide association study meta-analysis (n = 188 577 European-ancestry individuals; sample 1) were selected as instrumental variables. The effects of these SNPs on offspring BW were estimated using a structural equation model in the UK Biobank and Early Growth Genetics consortium (n = 230 069 European-ancestry individuals; sample 2) that enabled partitioning of the genetic associations into maternal- (intrauterine) and fetal-specific effects.ResultsWe found no evidence for a causal effect of maternal gestational HDL-C, LDL-C or triglyceride concentrations on offspring BW [standard deviation change in BW per standard deviation higher in HDL-C = −0.005 (95% confidence interval: −0.039, 0.029), LDL-C = 0.014 (−0.017, 0.045), and triglycerides = 0.014 (−0.025, 0.052)].ConclusionsOur findings suggest that maternal gestational HDL-C, LDL-C and triglyceride concentrations play a limited role in determining offspring BW. However, we cannot comment on the impact of these and other lipid fractions on fetal development more generally. Our study illustrates the power and flexibility of two-sample MR in assessing the causal effect of maternal environmental exposures on offspring outcomes.
Effects of Bacillus subtilis C-3102 on sow and progeny performance, fecal consistency, and fecal microbes during gestation, lactation, and nursery periods1,2
Authors: Menegat Mariana B , DeRouchey Joel M , Woodworth Jason C , Dritz Steve S , Tokach Mike D , Goodband Robert D 
Published: July 2019

AbstractThis study evaluated the effects of providing a dietary probiotic, Bacillus subtilis C-3102, to sows during gestation and lactation and to progeny after weaning on performance, fecal consistency, and fecal microbes. For the sow portion of the study, 29 sows and litters were used from day 30 of gestation until weaning. Sow treatments consisted of control diet or probiotic diet with B. subtilis C-3102 at 500,000 cfu/g of gestation feed and 1,000,000 cfu/g of lactation feed. For the nursery portion of the study, 358 weaned pigs, progeny of sows on study, were used in a 42-d nursery study. Nursery treatments consisted of control diet or probiotic diet with B. subtilis C-3102 and prebiotics at 500,000 cfu/g of nursery feed. Treatments were arranged in a split-plot design with sow treatment (control or probiotic diet) as main plot and nursery treatment (control or probiotic diet) as subplot. Performance, fecal consistency by fecal score method, and fecal microbes by isolation and enumeration method were assessed. In lactation, probiotic-fed sows tended (P = 0.057) to have increased feed intake, but it did not improve (P > 0.05) sow or litter performance in lactation. In the nursery, there were no (P > 0.10) interactions or main effects of sow or nursery treatments on overall growth performance. However, pigs born from control-fed sows had greater (P < 0.05) average daily gain, average daily feed intake, and body weight in late nursery than pigs born from probiotic-fed sows. Fecal score evaluation of nursing and nursery pigs indicated no influence (P > 0.05) of sow or nursery treatments on fecal consistency. Fecal microbial analysis revealed a modest modification in fecal microbial population by increasing (P < 0.05) the number of total Bacillus sp. in probiotic-fed sows and nursery pigs. Nursing piglets born from probiotic-fed sows carried over (P < 0.05) this modification in fecal microbial population preweaning. In conclusion, providing a probiotic based on B. subtilis C-3102 to sows during gestation and lactation and to progeny after weaning did not elicit noteworthy improvements in performance or fecal consistency, but there was a benefit on sow lactation feed intake. Fecal microbial analysis indicated a maternal-progeny intestinal microbiota relationship with pigs born from probiotic-fed sows displaying similar fecal microbial population as sows. However, pigs born from probiotic-fed sows demonstrated reduced growth rate and feed consumption in late nursery.
Impact of dietary zinc:copper ratio on the postprandial net portal appearance of these minerals in pigs1
Authors: Dalto Danyel Bueno , Audet Isabelle , Matte J Jacques 
Published: July 2019

AbstractThe present study compared the net intestinal absorption of zinc (Zn) and copper (Cu) after meals containing different dietary ratios among these trace elements. Ten 46-kg pigs were used in a cross-over design to assess the 10-h net portal-drained viscera (PDV) flux of serum Cu and Zn after ingestion of boluses containing ZnSO4 and CuSO4 in different Zn:Cu ratios (mg:mg): 120:20; 200:20; 120:8; and 200:8. Arterial Zn concentrations peaked within the first hour post-meal and responses were greater with 200 (0.9 to 1.8 mg/L) than with 120 mg (0.9 to 1.6 mg/L) of dietary Zn (dietary Zn × time, P = 0.05). Net PDV flux of Zn was greater (P = 0.02) with 200 than with 120 mg of dietary Zn and tended to be greater (P = 0.10) with 20 than with 8 mg of dietary Cu. The cumulative PDV appearance of Zn (% of dietary intake) was greater with 120 than 200 mg of dietary Zn from 8 h post-meal (P ≤ 0.04) and with 20 than 8 mg of dietary Cu from 7 h post-meal (P ≤ 0.05). At the end of the postprandial period (10 h), estimated PDV appearance of Zn was 16.0%, 18.4%, 12.0%, and 15.3% of Zn intake for 120:8, 120:20, 200:8, and 200:20 ratios, respectively. For Cu, irrespective of treatment, arterial values varied (P < 0.01) by less than 5% across postmeal times. Net PDV flux was not affected by treatments (P ≥ 0.12), but the value for ratio 120:20 was different from zero (P = 0.03). There was an interaction dietary Zn × dietary Cu on cumulative PDV appearance of Cu (% of dietary intake) at 30 min post-meal (P = 0.04) and thereafter at 3 h post-meal (P = 0.04). For the whole postprandial period (10 h), estimated PDV appearance of Cu was 61.9%, 42.1%, −17.1%, and 23.6% of Cu intake for 120:8, 120:20, 200:8, and 200:20 ratios, respectively. In conclusion, the present dietary amounts and ratios of Zn and Cu can affect the metabolic availability of both trace minerals for pigs. Ratios with 120 mg of dietary Zn maximized the postintestinal availability of both Zn and Cu.
The Influence of Obesity on Treatment and Outcome of Severely Burned Patients
Authors: Tapking Christian , Houschyar Khosrow S , Rontoyanni Victoria G , Hundeshagen Gabriel , Kowalewski Karl-Friedrich , Hirche Christoph , Popp Daniel , Wolf Steven E , Herndon David N , Branski Ludwik K 
Published: July 2019

AbstractObesity and the related medical, social, and economic impacts are relevant multifactorial and chronic conditions that also have a meaningful impact on outcomes following a severe injury, including burns. In addition to burn-specific difficulties, such as adequate hypermetabolic response, fluid resuscitation, and early wound coverage, obese patients also present with common comorbidities, such as arterial hypertension, diabetes mellitus, or nonalcoholic fatty liver disease. In addition, the pathophysiologic response to severe burns can be enhanced. Besides the increased morbidity and mortality compared to burn patients with normal weight, obese patients present a challenge in fluid resuscitation, perioperative management, and difficulties in wound healing. The present work is an in-depth review of the current understanding of the influence of obesity on the management and outcome of severe burns.
On-animal acoustic monitoring provides insight to ungulate foraging behavior
Authors: Northrup Joseph M , Avrin Alexandra , Anderson Charles R , Brown Emma , Wittemyer George 
Published: July 2019

Abstract
Foraging behavior underpins many ecological processes; however, robust assessments of this behavior for free-ranging animals are rare due to limitations to direct observations. We leveraged acoustic monitoring and GPS tracking to assess the factors influencing foraging behavior of mule deer (Odocoileus hemionus). We deployed custom-built acoustic collars with GPS radiocollars on mule deer to measure location-specific foraging. We quantified individual bites and steps taken by deer, and quantified two metrics of foraging behavior: the number of bites taken per step and the number of bites taken per unit time, which relate to foraging intensity and efficiency. We fit statistical models to these metrics to examine the individual, environmental, and anthropogenic factors influencing foraging. Deer in poorer body condition took more bites per step and per minute and foraged for longer irrespective of landscape properties. Other patterns varied seasonally with major changes in deer condition. In December, when deer were in better condition, they took fewer bites per step and more bites per minute. Deer also foraged more intensely and efficiently in areas of greater forage availability and greater movement costs. During March, when deer were in poorer condition, foraging was not influenced by landscape features. Anthropogenic factors weakly structured foraging behavior in December with no relationship in March. Most research on animal foraging is interpreted under the framework of optimal foraging theory. Departures from predictions developed under this framework provide insight to unrecognized factors influencing the evolution of foraging. Our results only conformed to our predictions when deer were in better condition and ecological conditions were declining, suggesting foraging strategies were state-dependent. These results advance our understanding of foraging patterns in wild animals and highlight novel observational approaches for studying animal behavior.
Arrested development? Investigating the role of bamboo in Araucaria Forest succession in Southern Brazil
Authors: Kellermann Betina , Lacerda André Eduardo Biscaia 
Published: July 2019

Abstract

Aims
Assessing the role of a dominant native bamboo species on tree species diversity and structure in the medium term.

Methods
Over a 7-year period, we studied the natural regeneration of two dominant forest types in Southern Brazil (Araucaria Forest or AF; Bamboo Forest or BF) after a bamboo (Merostachys skvortzovii Send.) die-off between 2004 and 2006. The study was carried out in the Embrapa Research Station in Caçador, Santa Catarina State, Brazil.

Important Findings
The die-off provided ideal conditions for the establishment of several species and it kickstarted forest succession dynamics, which in turn affected regeneration diversity. Tree species richness was relatively stable with a transitory increase between 2007 and 2014 in both AF and BF. However, species richness rose in BF because of a relative increase in abundance of some species (especially late and secondary species) while a plunge in some pioneer species drove an increase in diversity. Overall, we found that BF has a lower diversity of recruits and that density declined over time, while AF is more diverse, with a more stable density. In BF, the bamboo die-off created optimal conditions for initial regeneration development (mainly fast-growing pioneer trees), which quickly transited to higher size classes. Yet, after this initial stage of pioneer recruitment, the number of recruits dropped followed by a virtual absence of growth regardless of the species group as a result of a quick bamboo reestablishment. As bamboo recreated a dense understory it reduced species diversity to original levels, suggesting a self-maintaining cycle that halts forest succession. On the other hand, the bamboo die-off had little impact on AF where a slow recruitment process typical of old-growth forests was observed. The results indicate that the die-off event had a temporary effect on species diversity i.e. restricted to forests where bamboos are dominant in a similar process described in other southern South American forests. As the first study to observe the medium-term forest dynamics related to bamboo die-off, we can conclude that when being dominant, native bamboos can hinder forest regeneration, maintaining lower levels of diversity and arresting forest succession that lasts well beyond the short-term, post-die-off effects. Many forest fragments in the region are dominated by bamboos, thus their potential for conservation is at risk and requires appropriate management.
Evidence of a fast bar in the weakly-interacting galaxy NGC 4264 with MUSE
Authors: Cuomo V , Corsini E M , Aguerri J A L , Debattista V P , Coccato L , Costantin L , Dalla Bontà E , Iodice E , Méndez-Abreu J , Morelli L , Pagotto I , Pizzella A 
Published: July 2019

ABSTRACT
We present surface photometry and stellar kinematics of NGC 4264, a barred lenticular galaxy in the region of the Virgo Cluster undergoing a tidal interaction with one of its neighbours, NGC 4261. We measured the bar radius (abar = 3.2 ± 0.5 kpc) and strength (Sbar = 0.31 ± 0.04) of NGC 4264 from Sloan Digital Sky Survey imaging and its bar pattern speed (Ωbar = 71 ± 4 km s−1 kpc−1) using the Tremaine–Weinberg method with stellar-absorption integral-field spectroscopy performed with the Multi Unit Spectroscopic Explorer at the Very Large Telescope. We derived the circular velocity (Vcirc = 189 ± 10 km s−1) by correcting the stellar streaming velocity for asymmetric drift and calculated the corotation radius (Rcor = 2.8 ± 0.2 kpc) from the bar pattern speed. Finally, we estimated the bar rotation rate (Rcor/abar = 0.88 ± 0.23). We find that NGC 4264 hosts a strong and large bar extending out to the corotation radius. This means that the bar is rotating as fast as it can like nearly all the other bars measured so far even when the systematic error due to the uncertainty on the disc position angle is taken into account. The accurate measurement of the bar rotation rate allows us to infer that the formation of the bar of NGC 4264 was due to self-generated internal processes and not triggered by the ongoing interaction.