bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stakeholder trust in a state wildlife agency
Authors: Riley Shawn J. , Ford J. Kevin , Triezenberg Heather A. , Lederle Patrick E. 
Published: June 2018

ABSTRACTTrust in science and government regulatory agencies (e.g., state wildlife agencies) is a growing issue among wildlife managers and administrators who are attempting to engage stakeholders and develop effective, public wildlife conservation. However, a paucity of research has investigated attributes affecting stakeholder trust in wildlife agencies. We proposed a theoretical model of 2 key factors that can affect levels of trust: procedural fairness and technical competency. We used structured equation modeling to examine the influence of these factors on trust in a state wildlife agency by a prominent wildlife stakeholder, licensed hunters ≥18 years old. We tested the model with results from a mail‐back questionnaire (n = 2,708 respondents, 39.6% response rate) about trust in the Michigan Department of Natural Resources’ Wildlife Division. The respondent population closely reflected Michigan's population of hunting license‐holders regarding demographic and geographic composition. The modified measurement model fit the data well, supporting the uniqueness of the procedural fairness, technical competency, and trust measures. The test of the structural model indicted that stakeholder perceptions of procedural fairness and technical competence exhibited by agency personnel positively influenced trust; however, the coefficient for procedural fairness was nearly 4 times greater than that of perceived technical competence of personnel. Perceived congruency of values between stakeholders and the agency was the most important modifier of the relationship of fairness and competency on trust. Our findings identify influential pathways wildlife professionals generally and state wildlife agencies specifically can take to strengthen stakeholders’ trust and confidence in their agencies. The complexity of public wildlife management ensures that there always will be factors affecting trust in state wildlife agencies for which agencies can do little about. Yet, development of decisions processes perceived by stakeholders to be fair and transparent and investment in agency personnel with skills in stakeholder engagement likely will be effective ways to foster trust and confidence in state wildlife agencies. © 2018 The Wildlife Society.
Photocaged PNIPAM: A Light Tunable Thermal Responsive Polymer
Authors: He Lirong , Vibhagool Soravis , Zhao Hui , Hoven Voravee , Theato Patrick 
Published: June 2018

AbstractPhotocaged poly(N‐isopropyl acrylamide) (PNIPAM)s, copolymers consisting of N‐isopropyl acrylamide (NIPAM) and N‐isopropyl‐N‐(2‐nitrobenzyl) acrylamide, are prepared by free radical polymerization. Upon UV irradiation, the hydrophobic o‐nitrobenzyl group is cleaved, which subsequently releases the caged NH group and generates more hydrogen bonds with water. As a result, the lower critical solution temperature of caged PNIPAM can be obtained as a function of the photolysis degree of o‐nitrobenenzyl caged amides.
Self‐Healing Latex Containing Polyelectrolyte Multilayers
Authors: Cui Xiaoyu , Zhang Chi , Camilo Rendon P. , Zhang Huan , Cobaj Anisa , Soucek Mark D. , Zacharia Nicole S. 
Published: June 2018

AbstractSelf‐healing paints would have the potential benefit of protecting the underlying substrate and extending the coating's service life. As a step toward those types of coatings, this work examines layer‐by‐layer films of branched poly(ethylene imine)/poly(acrylic acid) with the inclusion of various types of latex particles with different Tg and different compositions. Due to high mobility of the polyelectrolyte chains when plasticized with water, water enabled self‐healing of these films is demonstrated, as well as steam enabled self‐healing. The films with various latex particles show different swelling ratios, surface hydrophilicity, as well as varying ability to self‐heal scratches. This self‐healing property is studied as a function of temperature. Also, the mechanical properties such as hardness and modulus of the films are measured.
Strong, Healable, and Recyclable Composite Paper Made from a Codispersion of Carbon Nanotube and Sulfonated Graphenal Polymer
Authors: Liang Linjie , Zhang Xiaohua , Zhang Xin , Zhao Jingna , Wu Jian , Liang Liyuan , Zhang Wei , Men Chuanling , Li Qingwen 
Published: June 2018

AbstractThe large surface area and rich functional groups of a 2D nanostructure, sulfonated graphenal polymer (SGP), provide a new strategy to assist the dispersion of carbon nanotubes (CNTs), far better than the dispersing ability of graphene oxide and sodium dodecyl benzene sulfonate. The efficient codispersion of CNTs and SGP facilitate the fabrication of composite buckypapers with wide‐range tunable fractions of CNT, SGP, and polymer, like poly(vinyl alcohol) (PVA), making it possible to search out the most optimal structure in the fraction space of the constituents. The globally strongest buckypaper is obtained at a CNT:SGP:PVA mass ratio of 7:3:10. Owing to the super hydrophilicity of SGP, and the hydrophilic characteristics of PVA as well, the composite structure can be reassembled with the aid of water, resulting in easy removal of creases and efficient cut heal/repair to broken papers. The healed papers can exhibit about 80% recovery of the tensile strength. Furthermore, just by mechanical stirring, the composite buckypaper can be redissolved in water for a totally green recycling reuse.
Silica‐Coated Magnetite Nanoparticles Carrying a High‐Density Polymer Brush Shell of Hydrophilic Polymer
Authors: Cai Yingying , Peng Wentao , Demeshko Serhiy , Tian Jia , Vana Philipp 
Published: June 2018

AbstractIntegrating the properties of magnetite nanoparticles (MNPs) and high‐density polymer brushes in one structure requires sophisticated synthetic designs and effective chemical approaches. A simple and versatile strategy for the fabrication of hydrophilic‐polymer‐capped magnetite‐core‐silica‐shell nanohybrids with well‐defined structure employing reverse microemulsion technique and reversible addition–fragmentation chain transfer (RAFT) polymerization is presented. The high‐density polymer brush allows precise patterning of the magnetic nanohybrids with a tunable interparticle distance ranging from 20 nm to 80 nm by controlling the polymer size. The high structural precision provides a near stand‐alone state of the MNPs in the nanohybrids with effectively inhibited magnetic interaction, as shown by superconducting quantum interference device (SQUID) measurements.
New strategies in achieving antiangiogenic effect: Multiplex inhibitors suppressing compensatory activations of RTKs
Authors: Shan Yuanyuan , Wang Binghe , Zhang Jie 
Published: June 2018

AbstractPathological angiogenesis plays a crucial role in malignant neoplasia. Vascular normalization has been confirmed as a promising strategy to promote chemotherapy efficacy. However, compensatory activation of alternative angiogenic receptor tyrosine kinases (RTKs) reduces vascular normalization and induces resistance. Moreover, complexity and heterogeneity of angiogenesis make it difficult to treat with single‐target agents. Accordingly, it has been proposed that multiplex inhibition of RTKs could enhance treatment efficacy and overcome resistance on the basis of the vascular normalization concept. Meanwhile, it is feasible to develop multiplex inhibitors against VEGFR‐2/Tie‐2/EphB4 because of their highly conserved ATP‐binding pockets. These inhibitors possess the properties of not only stabilizing the vascular normalization “time window” but also preventing the occurrence of resistance. This novel strategy has yielded promising results in the discovery of antiangiogenic agents. This review highlights the recent progress on the development of such angiogenesis inhibitors.
Mathematical Modeling of the Molecular Weight Distribution in Low Density Polyethylene. I. Steady‐State Operation of Multizone Autoclave Reactors
Authors: López‐Carpy Bruno , Saldívar‐Guerra Enrique , Zapata‐González Iván , García‐Franco César 
Published: June 2018

AbstractA comprehensive mathematical model and an efficient strategy for its solution are presented to describe the complete molecular weight distribution (MWD) in the free‐radical polymerization for the production of low density polyethylene (LDPE) in continuous stirred tank reactors at steady state. The kinetic scheme includes all the relevant reactions that affect the MWD. The solution for the complete MWD is given as explicit algebraic expressions that are solved sequentially taking advantage of the algebraic structure of the equations; the strategy can simulate LDPE multizone autoclave reactors in a simple and straightforward manner. No approximation for the moment's closure is used. Model simulations reasonably match average molecular weight data from an industrial plant, as well as results from the POLYRED software. A parameter sensitivity study for key kinetic constants shows that the MWD polydispersity is predominantly affected by the transfer to polymer rate constant. The solution is applied to linear, topological and mechanical chain‐scission mechanisms.
The iron chelator deferasirox synergises with chemotherapy to treat triple‐negative breast cancers
Authors: Tury Sandrine , Assayag Franck , Bonin Florian , Chateau‐Joubert Sophie , Servely Jean‐Luc , Vacher Sophie , Becette Véronique , Caly Martial , Rapinat Audrey , Gentien David , de la Grange Pierre , Schnitzler Anne , Lallemand François , Marangoni Elisabetta , Bièche Ivan , Callens Céline 
Published: June 2018

AbstractTo ensure their high proliferation rate, tumor cells have an iron metabolic disorder causing them to have increased iron needs, making them more susceptible to iron deprivation. This vulnerability could be a therapeutic target. In breast cancers, the development of new therapeutic approaches is urgently needed for patients with triple‐negative tumors, which frequently relapse after chemotherapy and suffer from a lack of targeted therapies. In this study, we demonstrated that deferasirox (DFX) synergises with standard chemotherapeutic agents such as doxorubicin, cisplatin and carboplatin to inhibit cell proliferation and induce apoptosis and autophagy in triple‐negative breast cancer (TNBC) cells. Moreover, the combination of DFX with doxorubicin and cyclophosphamide delayed recurrences in breast cancer patient‐derived xenografts without increasing the side‐effects of chemotherapies alone or altering the global iron storage of mice. Antitumor synergy of DFX and doxorubicin seems to involve downregulation of the phosphoinositide 3‐kinase and nuclear factor‐κB pathways. Iron deprivation in combination with chemotherapy could thus help to improve the effectiveness of chemotherapy in TNBC patients without increasing toxicity. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
BRCA1‐associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling
Authors: van de Ven Marieke , Liu Xiaoling , van der Burg Eline , Klarenbeek Sjoerd , Alexi Xanthippi , Zwart Wilbert , Dijcks Fred , Bouwman Peter , Jonkers Jos 
Published: June 2018

AbstractHereditary breast cancers in BRCA1 mutation carriers are mostly estrogen receptor α (ERα)‐negative and progesterone receptor (PR)‐negative; however, hormone depletion via bilateral oophorectomy does result in a marked reduction in breast cancer risk, suggesting that BRCA1‐associated breast tumorigenesis is dependent on hormone signaling. We used geneticaly engineered mouse models to determine the individual influences of ERα and PR signaling on the development of BRCA1‐deficient breast cancer. In line with the human data, BRCA1‐deficient mouse mammary tumors are ERα‐negative, and bilateral ovariectomy leads to abrogation of mammary tumor development. Hormonal replacement experiments in ovariectomized mice showed that BRCA1‐deficient mammary tumor formation is promoted by estrogen but not by progesterone. In line with these data, mammary tumorigenesis was significantly delayed by the selective ERα downregulator fulvestrant, but not by the selective PR antagonist Org33628. Together, our results illustrate that BRCA1‐associated tumorigenesis is dependent on estrogen signaling rather than on progesterone signaling, and call into question the utility of PR antagonists as a tumor prevention strategy for BRCA1 mutation carriers. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Cyclophilin B induces chemoresistance by degrading wild‐type p53 via interaction with MDM2 in colorectal cancer
Authors: Choi Tae Gyu , Nguyen Minh Nam , Kim Jieun , Jo Yong Hwa , Jang Miran , Nguyen Ngoc Ngo Yen , Yun Hyeong Rok , Choe Wonchae , Kang Insug , Ha Joohun , Tang Dean G , Kim Sung Soo 
Published: June 2018

AbstractColorectal cancer (CRC) is one of the leading causes of cancer‐related deaths worldwide. Chemoresistance is a major problem for effective therapy in CRC. Here, we investigated the mechanism by which peptidylprolyl isomerase B (PPIB; cyclophilin B, CypB) regulates chemoresistance in CRC. We found that CypB is a novel wild‐type p53 (p53WT)‐inducible gene but a negative regulator of p53WT in response to oxaliplatin treatment. Overexpression of CypB shortens the half‐life of p53WT and inhibits oxaliplatin‐induced apoptosis in CRC cells, whereas knockdown of CypB lengthens the half‐life of p53WT and stimulates p53WT‐dependent apoptosis. CypB interacts directly with MDM2, and enhances MDM2‐dependent p53WT ubiquitination and degradation. Furthermore, we firmly validated, using bioinformatics analyses, that overexpression of CypB is associated with poor prognosis in CRC progression and chemoresistance. Hence, we suggest a novel mechanism of chemoresistance caused by overexpressed CypB, which may help to develop new anti‐cancer drugs. We also propose that CypB may be utilized as a predictive biomarker in CRC patients. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Study of the partial wetting morphology in polylactide/poly[(butylene adipate)‐co‐terephthalate]/polyamide ternary blends: case of composite droplets
Authors: Fu Yang , Fodorean Gabriel , Navard Patrick , Peuvrel‐Disdier Edith 
Published: June 2018

AbstractThe prediction of the morphology of ternary polymer blends requires a good knowledge of the values of the three interfacial tensions. We selected three polymers, either biobased or biodegradable, polyamide (PA), poly[(butylene adipate)‐co‐terephthalate] (PBAT) and polylactide (PLA), and we accurately measured their interfacial tensions using the retraction method, varying the molar mass or inverting the phases. The following values of interfacial tension were obtained: γPBAT/PLA = 3.3 ± 0.7 mN m−1, γPA/PLA = 5.6 ± 0.3 mN m−1 and γPBAT/PA = 3.0 ± 0.4 mN m−1. These values were used to calculate the spreading coefficients giving rise to two negative coefficients and one coefficient close to zero. Ternary blends with various compositions, two different levels of viscosity for PBAT and different processing conditions were prepared. There was a very good agreement between the predictions of the spreading theory, when using the values of interfacial tension of the right order of magnitude, and the observed morphologies, whatever the polymer serving as a matrix. When PLA or PBAT was chosen as the matrix, the ternary blend morphology was composed of composite droplets, presenting a partial wetting morphology, dispersed in the polymer matrix. This morphology was observed whatever the composition, the viscosity of the PBAT phase and the processing conditions. A further calculation of the free energy confirmed this morphology. The formation process of this semi‐encapsulated morphology was observed during blending. © 2018 Society of Chemical Industry
Revealing the beneficial role of K in grain interiors, grain boundaries, and at the buffer interface for highly efficient CuInSe2 solar cells
Authors: Muzzillo Christopher P. , Poplawsky Jonathan D. , Tong Ho Ming , Guo Wei , Anderson Tim 
Published: June 2018

AbstractK incorporation within grain boundaries, grain interiors, and interfaces has been studied within CuInSe2 solar cells to better understand the beneficial or detrimental role of K distribution among these regions in chalcopyrite‐based solar cells. Solar cells have been fabricated with intentional K introduction into specific regions of the device including the CuInSe2/CdS interface (CuInSe2/KInSe2/CdS) and the grain interiors (Cu0.93K0.07InSe2/CdS). A control CuInSe2/CdS device was also studied to separate effects of K originating from the soda‐lime glass substrate from those of intentionally introduced K. The experiment was designed to understand K effects in Cu(In,Ga)Se2 solar cells while mitigating complications from multiple elements in the 3+ site. The distribution of all elements within these samples has been directly observed with sub‐nm resolution via atom probe tomography. In addition, electron beam–induced current measurements have been performed to correlate the atom probe tomography compositional profiles to the nanoscale carrier collection properties. The experiments show that a large decrease in the Cu/In ratio at the CdS interface can be achieved by forming KInSe2 at the absorber surface, which drastically improves the device efficiency. The results presented here show a direct link between K concentration, Cu depletion, and In accumulation, such that the Cu/In ratio significantly reduces with K incorporation. The findings help clarify the mechanism behind K‐induced efficiency enhancement.
Chitosan Nanocapsules for pH‐Triggered Dual Release Based on Corrosion Inhibitors as Model Study
Authors: Pitakchatwong Chutamart , Schlegel Isabel , Landfester Katharina , Crespy Daniel , Chirachanchai Suwabun 
Published: June 2018

AbstractChitosan (CS) is known for its uniqueness in terms of containing reactive functional groups, i.e., amino and hydroxyl groups, along the chain which offer the noncovalent bonds and chemical modifications. At pH 3 in emulsion system, the CS chains are under charge‐charge repulsive force, leading the polysaccharide chains to align as the hollow nanospheres and at that time, the crosslink leads to the nanocapsules. The CS nanocapsules allow the model cargos, i.e., corrosion inhibitors, entrapment not only via the noncovalent bond based on the weak interaction in the core for 2‐mercaptobenzothiazole (MBT) cargo but also via the chemical bonds based on the amino group remaining on CS structure to result in either amide or Schiff base linkage in case of 3‐nitrosalicylic acid (3NiSA) cargo. The release studies indicate that CS nanocapsules can release two cargoes upon pH change due to the acidic/basic‐triggered cleavage of bonds between cargoes and nanocapsules. Once corrosion occurs, resulting in variation of the local pH value, the CS nanocapsules release MBT in fast and 3NiSA in a slow, sustained manner. The efficiency of the approach is demonstrated using the nanocapsules for hindering the corrosion of copper as measured by electrochemical quartz crystal microbalance.
Coadministration of ginger extract–Lactobacillus acidophilus (cobiotic) reduces gut inflammation and oxidative stress via downregulation of COX‐2, i‐NOS, and c‐Myc
Authors: Deol Parneet Kaur , Khare Pragyanshu , Bishnoi Mahendra , Kondepudi Kanthi Kiran , Kaur Indu Pal 
Published: June 2018

Aim of the study was to evaluate a combination of ginger extract (GE; antioxidant, anti‐inflammatory) and Lactobacillus acidophilus (LAB; probiotic), in DMH‐DSS‐induced inflammation‐driven colon cancer, in Wistar rats. Effect of varying GE concentration on growth of LAB was assessed in vitro. Colonic histology and permeability, oxidative stress, serum proinflammatory cytokines, expression of selected genes, gut bacteria, and SCFA determination of gut content was monitored after treatment with agents alone or in combination, postdisease induction. Significant increase in LAB CFU was observed following 48 and 96 hr of incubation with GE; 0.4% w/v GE showed the best results and was used in the cobiotic. Cobiotic administration significantly reversed the DMH‐DSS‐induced colonic histological alterations. Significant (p < .05) reduction in lipid peroxidation and increase in antioxidant levels (catalase and SOD) was observed in cobiotic group, whereas individual agents did not show any effect. Restoration of colonic permeability, decrease in serum inflammatory burden, and downregulation of COX‐2, iNOS, and c‐Myc expression on treatment with cobiotic was significantly (p < .05) better than individual agents. Neither LAB nor cobiotic administration produced any change in gut bacteria nor SCFA levels, probably due to loss of LAB viability under adverse gut conditions. Study concludes that presented cobiotic has a promising therapeutic potential, which can be improved by a smartly designed formulation.
Preliminary studies on potential remediation of acid mine drainage‐impacted soils by amendment with drinking‐water treatment residuals
Authors: RoyChowdhury Abhishek , Sarkar Dibyendu , Datta Rupali 
Published: June 2018

AbstractMining operations result in a wide range of environmental impacts: acid mine drainage (AMD) and acid sulfate soils being among the most common. Due to their acidic pH and high soluble metal concentrations, both AMD and acid sulfate soils can severely damage the local ecosystems. Proper post‐mining management practices are necessary to control AMD‐related environmental issues. Current AMD‐impacted soil treatment technologies are rather expensive and typically not environmentally sustainable. We conducted a 60‐day bench‐scale study to evaluate the potential of a cost‐effective and environment‐friendly technology in treating AMD‐impacted soils. The metal binding and acid‐neutralizing capacity of an industrial by‐product, drinking water treatment residuals (WTRs) were used for AMD remediation. Two types of locally generated WTRs, an aluminum‐based WTR (Al‐WTR) and a lime‐based WTR (Ca‐WTR) were used. Highly acidic AMD‐impacted soil containing very high concentrations of metals and metalloids, such as iron, nickel, and arsenic, was collected from the Tab‐Simco coal mine in Carbondale, Illinois. Soil amendment using a 1:1 Al‐ and Ca‐WTR mix, applied at 5 and 10 percent rates significantly lowered the soluble and exchangeable fractions of metals in the AMD‐impacted soil, thus lowering potential metal toxicity. Soil pH increased from an extremely acidic 2.69 to a near‐neutral 6.86 standard units over the 60‐day study period. Results from this preliminary study suggest the possibility of a successful scale‐up of this innovative, cost‐effective, and environmentally sustainable technology for remediating AMD‐impacted acid sulfate soils.