bluuebunny/crossref_metadata_2025_split huggingface dataset:
The risk of developing major depression among individuals with subthreshold depression: a systematic review and meta-analysis of longitudinal cohort studies
Authors: Lee Y. Y. , Stockings E. A. , Harris M. G. , Doi S. A. R. , Page I. S. , Davidson S. K. , Barendregt J. J. 
Published: March 2018

AbstractBackgroundStudies have consistently shown that subthreshold depression is associated with an increased risk of developing major depression. However, no study has yet calculated a pooled estimate that quantifies the magnitude of this risk across multiple studies.MethodsWe conducted a systematic review to identify longitudinal cohort studies containing data on the association between subthreshold depression and future major depression. A baseline meta-analysis was conducted using the inverse variance heterogeneity method to calculate the incidence rate ratio (IRR) of major depression among people with subthreshold depression relative to non-depressed controls. Subgroup analyses were conducted to investigate whether IRR estimates differed between studies categorised by age group or sample type. Sensitivity analyses were also conducted to test the robustness of baseline results to several sources of study heterogeneity, such as the case definition for subthreshold depression.ResultsData from 16 studies (n= 67 318) revealed that people with subthreshold depression had an increased risk of developing major depression (IRR = 1.95, 95% confidence interval 1.28–2.97). Subgroup analyses estimated similar IRRs for different age groups (youth, adults and the elderly) and sample types (community-based and primary care). Sensitivity analyses demonstrated that baseline results were robust to different sources of study heterogeneity.ConclusionThe results of this study support the scaling up of effective indicated prevention interventions for people with subthreshold depression, regardless of age group or setting.
Mobilising alternative futures: generational accounting and the fiscal politics of ageing in Australia
Authors: SPIES-BUTCHER BEN , STEBBING ADAM 
Published: March 2018

ABSTRACTEconomists typically argue population ageing generates fiscal pressures by restricting the tax base while increasing demands for social spending. Alongside other economic pressures associated with neoliberalism, this dynamic contributes to a politics of ‘enduring austerity’ that limits governments’ fiscal discretion. The politics of population ageing reflects modelling techniques, such as generational accounting (GA), which, anticipating future deficits, create demands for policy action today to address projected intergenerational inequalities. Taking Australia as a case study, this paper explores the politics of GA in public budgetary processes. While existing critiques reject GA by arguing it relies on ‘apocalyptic’ or unreliable demography, we focus on a different kind of contestation, which applies the techniques and even the categories of GA to frame different problems and promote different solutions. We identify three sites of partisan contest that refocus fiscal modelling: including the tax side of the budget equation; comparing the cost of public provision to public subsidies for private programmes; and including the costs of environmental damage. At each site, the future-orientated logic of GA is mobilised to contest the policy implications of austerity. This complicates analysis that financialisation and neoliberalism necessarily ‘de-politicise’ policy by removing state discretion. Instead, we identify an increasingly important, if technocratic, form of political contestation that offers the possibility to promote more egalitarian responses to population ageing.
Evaluation of measles and rubella integrated surveillance system in Apulia region, Italy, 3 years after its introduction
Authors: Turiac I. A. , Fortunato F. , Cappelli M. G. , Morea A. , Chironna M. , Prato Rosa , Martinelli D. 
Published: March 2018

AbstractThis study aimed at evaluating the integrated measles and rubella surveillance system (IMRSS) in Apulia region, Italy, from its introduction in 2013 to 30 June 2016. Measles and rubella case reports were extracted from IMRSS. We estimated system sensitivity at the level of case reporting, using the capture–recapture method for three data sources. Data quality was described as the completeness of variables and timeliness of notification as the median-time interval from symptoms onset to initial alert. The proportion of suspected cases with laboratory investigation, the rate of discarded cases and the origin of infection were also computed. A total of 127 measles and four rubella suspected cases were reported to IMRSS and 82 were laboratory confirmed. Focusing our analysis on measles, IMRSS sensitivity was 82% (95% CI: 75–87). Completeness was >98% for mandatory variables and 57% for ‘genotyping’. The median-time interval from symptoms onset to initial alert was 4.5 days, with a timeliness of notification of 33% (41 cases reported ⩽48 h). The proportion of laboratory investigation was 87%. The rate of discarded cases was 0.1 per 100 000 inhabitants per year. The origin of infection was identified for 85% of cases. It is concluded that IMRSS provides good quality data and has good sensitivity; still efforts should be made to improve the completeness of laboratory-related variables, timeliness and to increase the rate of discarded cases.
Foundations of dependent interoperability
Authors: DAGAND PIERRE-ÉVARISTE , TABAREAU NICOLAS , TANTER ÉRIC 
Published: March 2018

AbstractFull-spectrum dependent types promise to enable the development of correct-by-construction software. However, even certified software needs to interact with simply-typed or untyped programs, be it to perform system calls, or to use legacy libraries. Trading static guarantees for runtime checks, thedependent interoperabilityframework provides a mechanism by which simply-typed values can safely be coerced to dependent types and, conversely, dependently-typed programs can defensively be exported to a simply-typed application. In this article, we give a semantic account of dependent interoperability. Our presentation relies on and is guided by a pervading notion of type equivalence, whose importance has been emphasized in recent work on homotopy type theory. Specifically, we develop the notions oftype-theoretic partial Galois connectionsas a key foundation for dependent interoperability, which accounts for the partiality of the coercions between types. We explore the applicability of both type-theoretic Galois connections and anticonnections in the setting of dependent interoperability. A partial Galois connection enforces a translation of dependent types to runtime checks that are both sound and complete with respect to the invariants encoded by dependent types. Conversely, picking an anticonnection instead lets us induce weaker, sound conditions that can amount to more efficient runtime checks.Our framework is developed in Coq; it is thus constructive and verified in the strictest sense of the terms. Using our library, users can specify domain-specific partial connections between data structures. Our library then takes care of the (sometimes, heavy) lifting that leads to interoperable programs. It thus becomes possible, as we shall illustrate, to internalize and hand-tune the extraction of dependently-typed programs to interoperable OCaml programs within Coq itself.
A Descriptive Analysis of Care Provided by Law Enforcement Prior to EMS Arrival in the United States
Authors: Klassen Aaron B. , Core S. Brent , Lohse Christine M. , Sztajnkrycer Matthew D. 
Published: March 2018

AbstractStudy ObjectivesLaw enforcement is increasingly viewed as a key component in the out-of-hospital chain of survival, with expanded roles in cardiac arrest, narcotic overdose, and traumatic bleeding. Little is known about the nature of care provided by law enforcement prior to the arrival of Emergency Medical Services (EMS) assets. The purpose of the current study was to perform a descriptive analysis of events reported to a national EMS database.MethodsThis study was a descriptive analysis of the 2014 National Emergency Medical Services Information System (NEMSIS) public release research data set, containing EMS emergency response data from 41 states. Code E09_02 1200 specifically identifies care provided by law enforcement prior to EMS arrival.ResultsA total of 25,835,729 unique events were reported. Of events in which pre-arrival care was documented, 2.0% received prior aid by law enforcement. Patients receiving law enforcement care prior to EMS arrival were more likely to be younger (52.8 [SD=23.3] years versus 58.7 [SD=23.3] years), male (54.8% versus 46.7%), and white (80.3% versus 77.5%). Basic Life Support (BLS) EMS response was twice as likely in patients receiving prior aid by law enforcement. Multiple-casualty incidents were five times more likely with prior aid by law enforcement. Compared with prior aid by other services, law enforcement pre-arrival care was more likely with motor vehicle accidents, firearm assaults, knife assaults, blunt assaults, and drug overdoses, and less likely at falls and childbirths. Cardiac arrest was significantly more common in patients receiving prior aid by law enforcement (16.5% versus 2.6%). Tourniquet application and naloxone administration were more common in the law enforcement prior aid group.ConclusionWhere noted, law enforcement pre-arrival care occurs in 2.0% of EMS patient encounters. The majority of cases involve cardiac arrest, motor vehicle accidents, and assaults. Better understanding of the nature of law enforcement care is required in order to identify potential barriers to care and to develop appropriate training and policy recommendations.KlassenAB, CoreSB, LohseCM, SztajnkrycerMD. A descriptive analysis of care provided by law enforcement prior to EMS arrival in the United States. Prehosp Disaster Med. 2018;33(2):165–170.
Genetic differences in macro-element mineral concentrations among 52 historically important tomato varieties
Authors: Labate Joanne A. , Breksa Andrew P. , Robertson Larry D. , King Benjamin A. , King Darwin E. 
Published: March 2018

AbstractTomato (Solanum lycopersicum) fruit quality and yield are highly dependent on adequate uptake of nutrients. Potassium, magnesium and calcium are essential elements that influence fruit quality traits such as colour, uniformity of ripening, hollow fruit, fruit shape, firmness and acidity. Sodium is not an essential element for tomato and can detrimentally compete with the absorption of potassium and calcium. Daily intakes of potassium, magnesium and calcium in human diets are typically below healthful levels, while sodium intake is often excessive. The objective of this study was to compare 52 diverse commercially important varieties of tomato for concentrations of potassium, magnesium, calcium and sodium in fruits. The tomatoes were produced in replicated plots in Geneva, NY in 2010 and 2011. Multiple fruits per plot were harvested vine-ripe, homogenized and assayed for cations. Analysis of variance showed significant differences among the 52 varieties for all four traits, i.e. cation concentrations (df = 51, P < 0.0001–0.0034) and no significant differences between years for any trait (df = 1, P = 0.3432–0.6770). Factor analysis showed a strong interrelationship between potassium and magnesium that was independent of calcium and sodium. Potassium and magnesium were highly significantly correlated with each other (r = 0.64, P < 0.0001). No other correlations between pairs of traits were observed. Results supported a genetic basis for potassium, magnesium, calcium and sodium concentrations that was consistent across environments (i.e. years). Results can contribute to the development of cultivars with favourable cation profiles in terms of human health and fruit quality.
Institutions, rule-following and conditional reasoning
Authors: HÉDOIN CYRIL 
Published: March 2018

AbstractThis paper is a contribution to the advancement of a naturalistic social ontology. Individuals participate in an institutionalized practice by following rules. In this perspective, I show that the nature, the stability, and the dynamics of any institution depend on how people reason about states of affairs that do not occur. That means that counterfactual reasoning is essential in the working of institutions. I present arguments for the importance of counterfactuals as well as a game-theoretic framework to account for them. Since the role of counterfactuals does not directly transpire in people's behavior, the whole discussion can be seen as a broad argument against behaviorism in philosophy and the social sciences.
Predator-secreted sulfolipids induce defensive responses in C. elegans
Authors: Liu Zheng , Kariya Maro J. , Chute Christopher D. , Pribadi Amy K. , Leinwand Sarah G. , Tong Ada , Curran Kevin P. , Bose Neelanjan , Schroeder Frank C. , Srinivasan Jagan , Chalasani Sreekanth H. 
Published: March 2018

AbstractAnimals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show that neuronal perception by C. elegans of a predator-specific molecular signature induces instantaneous escape behavior and a prolonged reduction in oviposition. Chemical analysis revealed this predator-specific signature to consist of a class of sulfolipids, produced by a biochemical pathway required for developing predacious behavior and specifically induced by starvation. These sulfolipids are detected by four pairs of C. elegans amphid sensory neurons that act redundantly and recruit cyclic nucleotide-gated (CNG) or transient receptor potential (TRP) channels to drive both escape and reduced oviposition. Functional homology of the delineated signaling pathways and abolishment of predator-evoked C. elegans responses by the anti-anxiety drug sertraline suggests a likely conserved or convergent strategy for managing predator threats.
Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
Authors: Huels D. J. , Bruens L. , Hodder M. C. , Cammareri P. , Campbell A. D. , Ridgway R. A. , Gay D. M. , Solar-Abboud M. , Faller W. J. , Nixon C. , Zeiger L. B. , McLaughlin M. E. , Morrissey E. , Winton D. J. , Snippert H. J. , van Rheenen J. , Sansom O. J. 
Published: March 2018

AbstractMany epithelial stem cell populations follow a pattern of stochastic stem cell divisions called 'neutral drift'. It is hypothesised that neutral competition between stem cells protects against the acquisition of deleterious mutations. Here we use a Porcupine inhibitor to reduce Wnt secretion at a dose where intestinal homoeostasis is maintained despite a reduction of Lgr5+ stem cells. Functionally, there is a marked acceleration in monoclonal conversion, so that crypts become rapidly derived from a single stem cell. Stem cells located further from the base are lost and the pool of competing stem cells is reduced. We tested whether this loss of stem cell competition would modify tumorigenesis. Reduction of Wnt ligand secretion accelerates fixation of Apc-deficient cells within the crypt leading to accelerated tumorigenesis. Therefore, ligand-based Wnt signalling influences the number of stem cells, fixation speed of Apc mutations and the speed and likelihood of adenoma formation.
Pre-Columbian earth-builders settled along the entire southern rim of the Amazon
Authors: de Souza Jonas Gregorio , Schaan Denise Pahl , Robinson Mark , Barbosa Antonia Damasceno , Aragão Luiz E. O. C. , Marimon Ben Hur , Marimon Beatriz Schwantes , da Silva Izaias Brasil , Khan Salman Saeed , Nakahara Francisco Ruji , Iriarte José 
Published: March 2018

AbstractThe discovery of large geometrical earthworks in interfluvial settings of southern Amazonia has challenged the idea that Pre-Columbian populations were concentrated along the major floodplains. However, a spatial gap in the archaeological record of the Amazon has limited the assessment of the territorial extent of earth-builders. Here, we report the discovery of Pre-Columbian ditched enclosures in the Tapajós headwaters. The results show that an 1800 km stretch of southern Amazonia was occupied by earth-building cultures living in fortified villages ~Cal AD 1250–1500. We model earthwork distribution in this broad region using recorded sites, with environmental and terrain variables as predictors, estimating that earthworks will be found over ~400,000 km2of southern Amazonia. We conclude that the interfluves and minor tributaries of southern Amazonia sustained high population densities, calling for a re-evaluation of the role of this region for Pre-Columbian cultural developments and environmental impact.
Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
Authors: Liu Junli , Huang Xinfang , Hao Shumeng , Wang Yan , Liu Manman , Xu Jing , Zhang Xingli , Yu Tao , Gan Shucheng , Dai Dongfang , Luo Xuan , Lu Qingyan , Mao Chaoming , Zhang Yanyun , Shen Nan , Li Bin , Huang Mingzhu , Zhu Xiaodong , Jin Jin , Cheng Xuhong , Sun Shao-Cong , Xiao Yichuan 
Published: March 2018

AbstractSystemic lupus erythematosus (SLE) is characterized by uncontrolled secretion of autoantibodies by plasma cells. Although the functional importance of plasma cells and autoantibodies in SLE has been well established, the underlying molecular mechanisms of controlling autoantibody production remain poorly understood. Here we show that Peli1 has a B cell-intrinsic function to protect against lupus-like autoimmunity in mice. Peli1 deficiency in B cells induces autoantibody production via noncanonical NF-κB signaling. Mechanically, Peli1 functions as an E3 ligase to associate with NF-κB inducing kinase (NIK) and mediates NIK Lys48 ubiquitination and degradation. Overexpression of Peli1 inhibits noncanonical NF-κB activation and alleviates lupus-like disease. In humans, PELI1 levels negatively correlate with disease severity in SLE patients. Our findings establish Peli1 as a negative regulator of the noncanonical NF-κB pathway in the context of restraining the pathogenesis of lupus-like disease.
Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment
Authors: Einfalt T. , Witzigmann D. , Edlinger C. , Sieber S. , Goers R. , Najer A. , Spulber M. , Onaca-Fischer O. , Huwyler J. , Palivan C. G. 
Published: March 2018

AbstractDespite tremendous efforts to develop stimuli-responsive enzyme delivery systems, their efficacy has been mostly limited to in vitro applications. Here we introduce, by using an approach of combining biomolecules with artificial compartments, a biomimetic strategy to create artificial organelles (AOs) as cellular implants, with endogenous stimuli-triggered enzymatic activity. AOs are produced by inserting protein gates in the membrane of polymersomes containing horseradish peroxidase enzymes selected as a model for natures own enzymes involved in the redox homoeostasis. The inserted protein gates are engineered by attaching molecular caps to genetically modified channel porins in order to induce redox-responsive control of the molecular flow through the membrane. AOs preserve their structure and are activated by intracellular glutathione levels in vitro. Importantly, our biomimetic AOs are functional in vivo in zebrafish embryos, which demonstrates the feasibility of using AOs as cellular implants in living organisms. This opens new perspectives for patient-oriented protein therapy.
Chromate replacement: what does the future hold?
Authors: Gharbi Oumaïma , Thomas Sebastian , Smith Craig , Birbilis Nick 
Published: March 2018

AbstractThe ubiquitous use of chromium and its derivatives as corrosion preventative compounds accelerated rapidly after the second industrial revolution, with such compounds now integral to modern society. However, the detrimental impact of chromium compounds on the environment and human health has prompted the need to revisit the majority of current industrial corrosion protection measures. This review retraces the origins of chromium replacement motivations, introducing the various legislative actions aimed at diminishing the use of chromium compounds, and critically reviews alternative corrosion preventative technologies developed in the recent decades to now. The review, herein, is intended for a broad audience in order to provide a concise update to an increasingly timely issue.
Altered DNA methylation associated with a translocation linked to major mental illness
Authors: McCartney Daniel L. , Walker Rosie M. , Morris Stewart W. , Anderson Susan M. , Duff Barbara J. , Marioni Riccardo E. , Millar J. Kirsty , McCarthy Shane E. , Ryan Niamh M. , Lawrie Stephen M. , Watson Andrew R. , Blackwood Douglas H. R. , Thomson Pippa A. , McIntosh Andrew M. , McCombie W. Richard , Porteous David J. , Evans Kathryn L. 
Published: March 2018

AbstractRecent work has highlighted a possible role for altered epigenetic modifications, including differential DNA methylation, in susceptibility to psychiatric illness. Here, we investigate blood-based DNA methylation in a large family where a balanced translocation between chromosomes 1 and 11 shows genome-wide significant linkage to psychiatric illness. Genome-wide DNA methylation was profiled in whole-blood-derived DNA from 41 individuals using the Infinium HumanMethylation450 BeadChip (Illumina Inc., San Diego, CA). We found significant differences in DNA methylation when translocation carriers (n = 17) were compared to related non-carriers (n = 24) at 13 loci. All but one of the 13 significant differentially methylated positions (DMPs) mapped to the regions surrounding the translocation breakpoints. Methylation levels of five DMPs were associated with genotype at SNPs in linkage disequilibrium with the translocation. Two of the five genes harbouring significant DMPs,DISC1andDUSP10, have been previously shown to be differentially methylated in schizophrenia. Gene Ontology analysis revealed enrichment for terms relating to neuronal function and neurodevelopment among the genes harbouring the most significant DMPs. Differentially methylated region (DMR) analysis highlighted a number of genes from the MHC region, which has been implicated in psychiatric illness previously through genetic studies. We show that inheritance of a translocation linked to major mental illness is associated with differential DNA methylation at loci implicated in neuronal development/function and in psychiatric illness. As genomic rearrangements are over-represented in individuals with psychiatric illness, such analyses may be valuable more widely in the study of these conditions.