bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of iodine-125 seed implantation efficacy in lung cancer using an enhanced CT-based nomogram model
Authors: Guibin Deng , Xiaolan Shen , Wei Zhang , Xiaoli Lan , Liu Dehui 
Published: November 2024

Background
Lung cancer, a leading cause of death, sees variable outcomes with iodine-125 seed implantation. Predictive tools are lacking, complicating clinical decisions. This study integrates radiomics and clinical features to develop a predictive model, advancing personalized treatment.

Objective
To construct a nomogram model combining enhanced CT image features and general clinical characteristics to evaluate the efficacy of radioactive iodine-125 seed implantation in lung cancer treatment.

Methods
Patients who underwent lung iodine-125 seed implantation at the Nuclear Medicine Department of Xiling Campus, Yichang Central People’s Hospital from January 1, 2018, to January 31, 2024, were randomly divided into a training set (73 cases) and a test set (31 cases). Radiomic features were extracted from the enhanced CT images, and optimal clinical factors were analyzed to construct clinical, radiomics, and combined models. The best model was selected and validated for its role in assessing the efficacy of iodine-125 seed implantation in lung cancer patients.

Results
Three clinical features and five significant radiomic features were successfully selected, and a combined nomogram model was constructed to evaluate the efficacy of iodine-125 seed implantation in lung cancer patients. The AUC values of the model in the training and test sets were 0.95 (95% CI: 0.91–0.99) and 0.83 (95% CI: 0.69–0.98), respectively. The calibration curve demonstrated good agreement between predicted and observed values, and the decision curve indicated that the combined model outperformed the clinical or radiomics model across the majority of threshold ranges.

Conclusion
A combined nomogram model was successfully developed to assess the efficacy of iodine-125 seed implantation in lung cancer patients, demonstrating good clinical predictive performance and high clinical value.
No association between genetically predicted vitamin D levels and Parkinson’s disease
Authors: Wang Zihao , Xia Huan , Ding Yunfa , Lu Ranran , Yang Xinling 
Published: November 2024

Background
Parkinson’s disease (PD) is a neurodegenerative disorder, primarily characterized by motor impairments. Vitamin D has several regulatory functions in nerve cell survival and gene expression via its receptors. Although research has shown that vitamin D deficiency is prevalent among PD patients, the causal link to PD risk remains unclear. This study aims to investigate the causal relationship between vitamin D and PD using a bidirectional two-sample Mendelian randomization (MR) analysis method.

Methods
This study applied a bidirectional two-sample MR analysis to explore the causal link between vitamin D and PD. We selected statistically significant single nucleotide polymorphisms (SNPs) related to 25-hydroxyvitamin D (25(OH)D) as instrumental variables (IVs), ensuring no association with known confounders. The analysis used GWAS data from over 1.2 million Europeans across four major published datasets, elucidating the genetic correlation between vitamin D levels and PD.

Results
We identified 148 instrumental SNPs associated with 25(OH)D. After adjustment for confounding-related SNPs, 131 SNPs remained in the analysis. Data from three PD cohorts revealed no significant correlation between 25(OH)D levels and PD risk using the IVW method (Pcohort1 = 0.365, Pcohort2 = 0.525, Pcohort3 = 0.117). The reverse MR analysis indicated insufficient evidence of PD causing decreased vitamin D levels (P = 0.776).

Conclusion
This is the first study to use bidirectional MR across three PD cohorts to investigate the causal relationship between vitamin D and PD. The results indicate that vitamin D levels are not significantly causally related to PD risk at the genetic level. Therefore, future studies should exercise caution when investigating the relationship between vitamin D levels and PD risk. While no direct causal link exists between vitamin D levels and PD, this does not preclude the potential of vitamin D levels as a biomarker for PD diagnosis. Furthermore, larger-scale longitudinal studies are necessary to evaluate the diagnostic and predictive value of vitamin D levels in PD.
Periampullary Diffuse Large B-Cell Lymphoma Presenting as Acute Pancreatitis
Authors: Abramowitz Binyamin R. , Ridout Nicholas , Attia Hagar , Li Zhonghua , Hammill Patrick J. , Grossman Evan B. 
Published: November 2024

ABSTRACT
Periampullary malignancies are uncommon and encompass a wide variety of tumors. Early and accurate biopsy-proven diagnosis is important because different malignancy subtypes warrant different management and treatment plans. We present a unique and rare case of periampullary lymphoma, initially presenting as acute pancreatitis.
Between Near East and Eurasian Nomads - Tables
Authors: Davtyan Ruben 
Published: November 2024

<p>The site of Lori Berd, located in northern Armenia, is home to an extraordinary necropolis that once housed the dead of the local elite during a period that spanned from 2200 to 400 BC. Influenced both by Urartian conquests from the south and by invasions from the Eurasian nomadic tribes from the north, the people of this region buried their dead with prestigious artefacts, complex customs, and a particular reverence shown towards horses during the later stages of the Early and Middle Iron Ages (1000–550 BC). This volume offers a detailed account of the archaeological significance of the site, providing detailed accounts of thirty-one tombs, the majority of which have never before been comprehensively published, and seeking to set Lori Berd in its broader historical and material context. Through this approach, the book offers a comprehensive exploration of the Iron Age in the South Caucasus, unravelling the interconnected themes of wealth, power, and cultural expressions.</p>
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<p>Tables to: Ruben Davtyan, ‘Between Near East and Eurasian Nomads. Representation of Local Elites in the Lori Berd Necropolis during the First Half of the First Millennium BC’, ARAXES, 4 (Turnhout: Brepols, 2024) </p>
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Allowable total error in CD34 cell analysis by flow cytometry based on state of the art using Spanish EQAS data
Authors: Fernández-Luis Sara , Comins-Boo Alejandra , Pérez-Pla Fernando , Irure-Ventura Juan , Insunza Gaminde Andrés , López-Hoyos Marcos , Blanco-Peris Lydia , Martín Alonso M. Carmen , San Segundo Arribas David 
Published: November 2024

Abstract

Objectives
CD34+ hematopoietic stem cell (HSC) enumeration, crucial for HSC transplantation, is performed by flow cytometry to guide clinical decisions. Variability in enumeration arises from biological factors, assay components, and technology. External quality assurance schemes (EQAS) train participants to minimize inter-laboratory variations. The goal is to estimate total error (TE) values for CD34 cell enumeration using state-of-the-art (SOTA) methods with EQA data and to define quality specifications by comparing TE using different cutoffs.

Methods
A total of 3,994 results from 40 laboratories were collected over 11 years (2011–2022) as part of the IC-2 Stem Cells Scheme of the GECLID Program that includes absolute numbers of CD34 cells. The data were analyzed in two periods: 2011–2016 and 2017–2022. The TE value achieved by at least 60 %, 70 %, 80 %, and 90  % of laboratories was calculated across the two different periods and at various levels of CD34 cell counts: above 25, 25 to 15, and under 15 cells/μL.

Results
A decrease in the SOTA-based TE for CD34 cell enumeration was observed in the most recent period in 2017–2021 compared with 2012–2016. A significant increase of P75 TE values in the low CD34 range (<15 cells/μL) levels was found (p<0.001).

Conclusions
Technical advancements contribute to the decrease TE over time. The TE of CD34 cell FC counts is measure-dependent, making it responsive to precision enhancement strategies. The TE measured by EQAS in this study may serve as a quality specification for implementing ISO 15189 standards in clinical laboratories for CD34 cell enumeration.
Evaluation of potential natural enemies of hibiscus mealybug, Nipaecoccus viridis (Hemiptera: Pseudococcidae) in Florida citrus
Authors: Middleton Eric G. , Demard Emilie P. , Diepenbrock Lauren M. 
Published: November 2024

Abstract
Hibiscus mealybug Nipaecoccus viridis (Newstead; Hemiptera: Pseudococcidae) is a newly established pest in Florida citrus. In its native range, hibiscus mealybug is controlled by a suite of natural enemies. However, the potential predator population for this pest in Florida is currently unknown. Identifying and promoting natural enemies that prey on hibiscus mealybug in the newly established region are key to achieving sustainable management of this pest. We evaluated commercially available predators and field-collected predators for the ability to consume juvenile life stages of hibiscus mealybug. Additionally, we evaluated an augmentative release of Cryptolaemus montrouzieri (Mulsant; Coleoptera: Coccinelidae) inside of a citrus under protective screen (CUPS) production system to control a hibiscus mealybug infestation. In no-choice assays, we found that the commercially available predator Cr. montrouzieri consumed all juvenile stages of hibiscus mealybug, and another, Chrysoperla carnea (Stephens; Neuroptera: Chrysopidae), was able to consume eggs but showed a clear preference for nymphs. Other commercially available predators did not consume any juvenile life stage of hibiscus mealybug. Two field-collected predators consumed both nymphs and ovisacs at high rates in no-choice tests: Euborellia annulipes Lucas (Dermapter: Anisolabididae) and Ceraeochrysa sp. (Neuroptera: Chrysopidae). Moreover, ten species of natural enemies were identified from mealybug clusters sampled from the fields among which two predators, Fragosa sp. (Diptera: Syrphidae) and Anatrachyntis badia (Hodges; Lepidoptera: Cosmopterigidae), and two parasitoids, Anagyrus dactylopii (Howard; Hymenoptera: Encyrtidae) and Aprostocetus sp. (Hymenoptera: Eulophidae) were found in high abundance. In the augmentative release, we found a reduction in pest population after the release of Cr. montrouzieri. However, without additional resources to maintain the predator, hibiscus mealybug population increased once the beetle population died. Our results indicate that Cr. montrouzieri is an effective commercially available predator of hibiscus mealybug and that several naturally occurring predators and parasitoids prey on hibiscus mealybug in Florida citrus.
Factors bridging medical graduate students’ training and future academic achievements of dermatologists in China
Authors: Shen Chen , Yin Kun , Zhang Peng , Zhang Qing-Xiang , Wang Bo , Tao Juan , Yang Jing 
Published: November 2024

Abstract

Objectives
Dermatology is highly competitive among medical students in China, yet, limited research has explored the factors influencing their career achievements during their studies. This study aims to examine how demographic and academic factors during training impact future career success in dermatology graduates.

Methods
A retrospective analysis of 61 dermatology graduates (2010–2020) from Wuhan Union Hospital was conducted. The correlation between demographic and academic data and career development indicators using Pearson’s chi-squared or Fisher’s exact test.

Results
The results revealed that pursuing a doctoral degree after completing master’s training, which entails a greater investment of time and effort, was closely associated with future career achievements. In contrast, the age of enrollment in graduate studies did not prove to be a determining factor. Additionally, in-depth training in research ability, demonstrated by the involvement in national research projects and the publication of high-quality science citation index (SCI) papers, exerted a positive influence on the future professional development. Besides, in terms of future promotions to administrative, teaching, and medical titles, male graduates exhibited a distinct advantage over their female counterparts.

Conclusions
These results suggest that in the medical field, the quality of education and training is more decisive for career development than other factors, such as the age of enrollment. On the other hand, the observed gender advantage in career promotions reflects potential structural inequalities within the medical profession, warranting further investigation and improvement.
Synthesis of motexafin gadolinium: A promising radiosensitizer and imaging agent for cancer therapy
Authors: Kalisha Vali Y. , Islam Imadul , Al Somaie Barrak , Al Sayyari Abdulrahman Abdullah , Gundla Rambabu , Tamboli Yasinalli 
Published: November 2024

Abstract
An improved, greener synthesis of motexafin gadolinium (MGd), a promising radiosensitizer and imaging agent that has the potential to treat or diagnose cancer, has been developed. Notably, this study addresses critical difficulties related to MGd synthesis and analysis of possible approaches, minimizing hazardous reagents/solvents, without column chromatography. The synthesis has been improved to enhance the overall yield and purity of MGd. The process changes outlined in this study are intended to lower production costs and time while maintaining the compound’s characteristics. This synthesis of MGd is an important step toward attaining its full potential in the diagnosis and treatment of cancer.
Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells
Authors: Chen Yijie , Sha Wenqi , Zhang Yifan , Kou Wanyi , Yang Liu , Guo Ruixin , Li Chenyang , Zhao Junjie , Wang Zhenghui 
Published: November 2024

Abstract

Objective
Dysregulation of chondrogenic differentiation is associated with osteoarthritis (OA). The myokine irisin is beneficial in OA treatment; yet, the underlying mechanism is not fully understood. Long noncoding RNAs (lncRNAs) act as important regulators of chondrocyte differentiation. This study was conducted to address the role of lncRNAs in mediating irisin-induced chondrocyte differentiation.

Methods
We investigated the irisin-regulated lncRNA profile change in human mesenchymal stem cells (MSCs) using published whole transcriptome sequencing data. We predicted their potential targets and competitive endogenous RNA (ceRNA) prediction and analyzed their molecular functions using functional enrichment analysis.

Results
More differentially expressed lncRNAs (DElncRNAs) were observed in irisin-treated samples. The top irisin-induced lncRNAs were associated with OA or chondrogenic differentiation, including XIST, PAX8-AS1, CASC15, LINC01618, and DLX6-AS1. The DEGs co-expressed with DElncRNAs were enriched in skeletal system development, extracellular matrix (ECM) organization, cell adhesion, and inflammation associated pathways. Several lncRNAs likely acted as ceRNAs to regulate downstream mRNAs including ROR2 and SORBS1 in in OA or chondrogenic differentiation.

Conclusions
We demonstrate the global regulation of lncRNAs by irisin during chondrogenic differentiation of human MSCs. Further study is required to characterize the key irisin-regulated lncRNAs in chondrogenic differentiation
Multi-scale finite element simulation of needle-punched quartz fiber reinforced composites
Authors: Niu Weijing , Yan Xiaopeng , Shi Haolin , Guo Zhangxin 
Published: November 2024

Abstract
To investigate the effects of different needling parameters on the mechanical properties of quartz needled felts and their composites, this paper proposes a multi-scale modeling approach to simulate and calculate the mechanical properties of needled quartz fiber-reinforced composites. Firstly, based on the characteristics of needle-punching technology, the morphology of needle-punched composites was analyzed at a microscopic scale, and the quartz fiber structure was divided into three typical representative regions. Then, a periodic single-cell model of needled composites was established. Meanwhile, this article also analyzes the influence of parameters such as needling density, needle type, and needling depth on the mechanical properties of needled composites.
25 años de operación del Programa de Rondas Interlaboratorios de Análisis de Alimentos (PRIDAA): Aportes a la evaluación del desempeño de laboratorios de análisis químico de alimentos de Latinoamérica
Authors: Lois-Martínez Mónica , López-Calvo Rebeca , Morales-Herrera Ileana 
Published: November 2024

El Programa de Rondas Interlaboratorios de Análisis de Alimentos (PRIDAA) fue diseñado y desarrollado entre los años 1998 y 2023 por el Centro Nacional de Ciencia y Tecnología de Alimentos - CITA, de la Universidad de Costa Rica, para ofrecer un programa accesible de ensayos de aptitud en química de alimentos a laboratorios de Latinoamérica. El programa operó en forma regular durante ese tiempo, con entre cuatro y cinco rondas por año correspondientes a cinco grupos de alimentos: cereales y derivados, frutas y derivados, lácteos, productos cárnicos o de pescado y café tostado, para evaluar los análisis de componentes nutricionales o parámetros de calidad. El diseño tomó como referencia la Guía ISO/IEC 43:1 y el “International Harmonized Protocol for Proficiency Testing of (Chemical) Analytical Laboratories” elaborado por IUPAC/ISO/AOAC, y adoptó luego la norma INTE/ISO/IEC 17043:2013, que fue la referencia para la acreditación del programa con el Ente Costarricense de Acreditación, obtenida en el año 2020. Durante los veinticinco años de operación se completaron 108 rondas donde participaron 91 laboratorios de dieciséis países de Latinoamérica. El perfil de participantes fue 54 % laboratorios institucionales, 24 % laboratorios privados de servicio y 22 % laboratorios de control de calidad de industrias de alimentos. Los países con mayor participación fueron Costa Rica, Guatemala y Ecuador, aportando el 56 % de los laboratorios. Los resultados obtenidos en estos años fueron principalmente retroalimentación para los participantes, para la mejora de su desempeño, pero también permitieron identificar los análisis en los que los laboratorios tienen mejor desempeño general y los ensayos más complejos para lograr resultados satisfactorios. El proceso de preparación para la acreditación llevó a mejoras en las metodologías de cálculo empleadas, lo que permitió realizar los cálculos estadísticos y la toma de decisiones con mayor facilidad, y asegurar resultados confiables para los laboratorios participantes.
Assessment of heavy metal contamination and health risk of lotus root in major producing areas of China
Authors: Zhou L.H. , Huang W.H. , Ma L.F. , Li J.C. , Jin Y.J. , Cao X.L. , Li M. , Wang W.H. , Guo S.L. , Xia X. 
Published: November 2024

AbstractLotus root is a popular vegetable known for its nutritional value and unique taste. However, it can be susceptible to heavy metal contamination, which has raised concerns about its safety for consumption. This study aimed to analyse the extent of heavy metal contamination in lotus roots and assess the potential health risks associated with their consumption. The results showed that all measured heavy metal concentrations were below the maximum allowable limits, with contamination indices for all metals across nine provinces remaining below 1.0, classifying the lotus roots as “safe” for consumption. Non-carcinogenic risk assessment using the THQ showed values below 1.0 for all heavy metals in both adults and children, indicating negligible health risks. The HI was calculated as 0.107 for adults and 0.126 for children, with arsenic contributing significantly to these values at 47.76% for adults and 39.55% for children. The carcinogenic risk assessment revealed Carcinogenic Risk (CR) values of 8.37 × 10−8 for Pb, 2.04 × 10−5 for Cr, and 2.30 × 10−5 for As in adults, and 9.86 × 10−8 for Pb, 2.40 × 10−5 for Cr, and 2.71 × 10−5 for As in children. All CR values were within the acceptable range, indicating no apparent carcinogenic effects from lotus root consumption at current intake levels. However, it was noted that increased consumption could elevate risks associated with As, with limits of 174 and 93 g for adults and children, respectively, to maintain safety.
Estimation of the world market and application of nanomaterials in the aerospace industry
Authors: Malyshev Viktor , Gab Angelina , Kovalenko Viktoriia , Lipskyi Yurii , Shakhnin Dmytro 
Published: November 2024

The object of the study is the global aerospace market status, segment analysis, dynamics, competition, and prospects. The methods of searching and analyzing literature data, summarizing, systematizing, and visualizing data with diagrams are used.
The aerospace industry is at the forefront of technological innovation and is constantly searching for new advanced materials to improve productivity, efficiency, and safety. The aerospace market encompassing the design, manufacture, and maintenance of aircrafts, space vehicles, and related systems. It includes the commercial and military sectors, as well as the space exploration field.
The world market of the aerospace industry was studied. Factors affecting the market positively and negatively were identified. According to the global aerospace market segmentation by vehicle types, the leading position in 2023 was occupied by the commercial aircrafts segment with a share of 63.4 %; by the vehicle size – by the narrow-body aircraft segment (72.4 %); by the end consumer – by the private sector segment (65.4 %); by operation – by manually operated aircrafts segment (79.4 %); and by geographic regions – by the North American segment (47.3 %). The main strategic trends and directions of the further aerospace market development are presented.
The world market of aerospace materials was studied. Factors affecting market dynamics are identified, and market challenges are highlighted. According to the world aerospace market segmentation by the materials types, the leading place in 2022 belonged to the composite materials segment with a share of 69 %; by the aircraft type – to the commercial aircrafts segment (51 %); and by geographical regions – to the European segment (35.0 %).
The trends of the sustainable aerospace industry development are summarized: modern aircraft design, use of sustainable aviation fuel, urban air mobility, modern traffic technology, and air transportation management optimization. For each trend, possible actions leading to changes in the aerospace industry are considered.
The question of the nanomaterials use in the space industry is considered. Some characteristics and possibilities of application of nanocomposite materials, nanocoatings, nanofluids, nanosensors, and carbon nanotubes, as well as examples of the nanomaterials application in aircraft components are given. The industry problems are identified, and their possible solutions are given.