bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the generalizability of a National Burn Database to the United States pediatric burn injury population
Authors: Dalal Sujata , Miles M. Victoria Purvis , Solis‐Beach Kyra Jeanine , Thakur Bhaskar , Suman‐Vejas Oscar E. , Ryan Colleen M. , Stewart Barclay T. , Carrougher Gretchen J. , Orton Caitlin , Kowalske Karen 
Published: November 2024

AbstractBackgroundA national database is used to evaluate pediatric burn survivor outcomes, but the generalizability to the United States pediatric burn injury population is unclear, as only 60% of enrollees are U.S. residents. An increased understanding of population similarities and differences between residents of the United States and residents of Mexico treated in the United States within this database will help determine its ability to extrapolate.ObjectiveAssess the generalizability of a national burn database to the U.S. pediatric burn injury population.DesignThis retrospective cohort study analyzed pediatric enrollees in a burn database. Data were stratified into children who were residents of the United States or Mexico at time of injury and grouped by age into <5 years, 5–10 years, and >10 years.SettingNot applicable.ParticipantsA total of 2043 children enrolled in the database from 1998 to 2020.InterventionsNot applicable.Main Outcomes MeasuredDetermination of similarities and differences between gender, injury etiology, total body surface area injured, length of stay, and place of injury between the two groups.ResultsBoth groups showed an increased incidence of burn injury among males as they aged. In U.S. residents, the most frequent etiology in patients <5 years was scald (292 [53.6%]), followed by fire/flame (157 [28.8%]). In residents of Mexico, fire/flame burns were more frequent in all ages and electric burns were more common among children >5 years. In both groups, outdoor injuries became more common as children aged. Children from Mexico had larger burns and longer lengths of hospital stay than children from the United States across all ages.ConclusionDifferences between U.S. and Mexico groups were likely attributable to children with more severe burns being transferred to the United States for care, whereas those with low‐severity burns were treated locally. This suggests that children from Mexico in the database were not representative of the pediatric burn injury population of the United States or Mexico more broadly and caution should be used before generalizations are made using this database.
Ferrocenyl‐Containing Fe(II)‐Bipyridinedicarboxamide Polysiloxane Complexes With Multiredox Activity
Authors: Deriabin Kontantin V. , Gorodnyaya Elena V. , Kocheva Anastasia N. , Volkov Alexey I. , Levin Oleg V. , Islamova Regina M. 
Published: November 2024

ABSTRACTFerrocenyl‐containing Fe(II)‐bipyridinedicarboxamide polysiloxane complexes with two redox metal centers were obtained by anionic ring‐opening polymerization, polycondensation, and complexation reactions utilizing various FeII:Bipy molar ratios of 1:(3–12). The polymer ligand was characterized by liquid‐state NMR, FTIR, and gel permeation chromatography (M

n
= 8800). The structure of the polymer‐metal complexes (PMCs), that is, the presence of ferrocenyl groups and [FeII(Bipy)3] coordination cross‐links with FeII–NBipy bond formation, was confirmed by solid‐state NMR, FTIR, UV–vis, and EDX. The PMCs exhibit multiredox activity showing three redox waves at E

1/2
≈ −1.3, 0.2, and 1.0 V related to Fc/Fc+ couple, [Fe(Bipy)2]+/[FeII(Bipy)3]2+, and [Fe(Bipy)3]2+/[Fe(Bipy)3]3+ transformations. The PMCs possess electrochromic properties resulting from the reduction–oxidation of ferrocenyl (Fc/Fc+) and [FeII(Bipy)3] fragments and leading to changes in intensity of bands at 628, 542, and 380 nm in the UV–vis spectra (coloring efficiency reaches 13.4 cm2·C−1). The PMCs are flexible, stretchable, and mechanically strong silicone materials with elongation at break, tensile strength, and Young's modulus reaching 110%, 3.5 MPa, and 21.8 MPa, respectively, with self‐healing ability at 100°C. The described properties expand applications of PMCs as multiredox materials in polymer engineering for fabrication of (opto)electronic devices and protective coatings with a long service life compared to previously reported multiredox polymers.
Respiratory Morbidity Among Children Undergoing Surgical Resection for a Congenital Lung Malformation
Authors: Halbert‐Elliott Kyra M. , Sescleifer Anne M. , Mogayzel Peter J. , Kunisaki Shaun M. 
Published: November 2024

ABSTRACTBackgroundCongenital lung malformations (CLMs) are the most common condition requiring lung surgery in children. Although surgical resection is generally well tolerated in the immediate postoperative period, long‐term outcomes are not well studied. In this paper, we sought to define the risk of childhood respiratory morbidity, specifically asthma and pneumonia, in patients who underwent CLM resection.MethodsAfter IRB approval, a retrospective study was conducted on all pediatric CLM resections performed at a single tertiary care children's hospital between January 2013 and December 2022. The primary outcome measures were the diagnosis of asthma and/or pneumonia more than 30 days after resection. Clinical and demographic characteristics were evaluated in univariate analysis and multivariable logistic regression as appropriate (p < 0.05).ResultsOf the 54 patients who underwent CLM resection, 36 (67%) met inclusion criteria. The median age at resection was 6.2 months (IQR: 4.3–9.0), and the median follow‐up period was 3.7 years (IQR: 1.7–5.7). Twelve were subsequently diagnosed with asthma at a median age of 3.3 years (IQR: 2.1–4.5). These observed asthma rates were significantly higher than expected when compared to nonlung surgery controls (33% vs. 6%, p < 0.01). Seven (21%) children were diagnosed with pneumonia, but this was not significantly different.ConclusionThese data suggest that children undergoing lung resection for a CLM may be at an increased risk for the development of early childhood asthma. Given the potential implications for preoperative counseling and postoperative follow‐up, multicenter studies to validate these findings are warranted.
Internal Temperature of Neonatal Endotracheal Tube Predicted by Infrared Thermography: A Neonatal Bench Study
Authors: Hamada Keisuke , Hirakawa Eiji , Tanabe Takashi , Mine Takashi , Ichikawa Tatsuki , Nagata Yasuhiro 
Published: November 2024

ABSTRACTIntroductionNeonatal ventilators are managed by monitoring the inspiratory gas temperature with a probe placed outside the incubator, although the temperature decreases as the gases passe through the ventilator circuit extension tube and endotracheal tube (ETT). There are no established methods for measuring the internal temperature of the ETT. This bench study aimed to investigate the feasibility of using infrared thermography (IRT) to predict the internal temperature of the ETT.MethodsA new method for predicting the internal ETT temperature using an IRT camera was established, and its accuracy and reliability were evaluated under various conditions. The external surface temperature of the ETT was measured with IRT, and the internal temperature was measured with thin thermocouples, which has minimal effect on ventilation and served as a true value. Temperature measurements were taken at two points, distal and proximal, respectively, to capture temperature changes during passage of gases through the ETT.ResultsThis method allowed prediction of the internal ETT temperature with high accuracy (R2Adj = 0.946 and 0.974 at the proximal and distal ends, respectively). The internal and external temperatures of the ETT were related to the incubator temperature and ventilator mode. The effects of the size of the ETT, the set temperature of the constant‐temperature tank, and the heated humidifier temperature were limited.ConclusionThis non‐contact method of internal temperature prediction allows continuous monitoring without interfering with ventilation, and will help airway management in the neonatal intensive care unit.
In vitro screening of UGT2B10 in silico prioritized putative ligands from drugs used in the pediatric hematopoietic stem cell transplantation setting
Authors: Bennani Yahia , Ben Hassine Khalil , Gencaslan Muhammed , Boudal‐Khoshbeen Mary , Samer Caroline , Ansari Marc , Daali Youssef , Satyanarayana Uppugunduri Chakradhara Rao 
Published: November 2024

AbstractUGT2B10 is a phase II drug metabolizing enzyme with limited information on its role in the metabolism of drugs, especially in the pediatric hematopoietic stem cell transplantation setting. Previously, we investigated UGT2B10's role through in silico analyses and prioritized acetaminophen (APAP), lorazepam (LOR), mycophenolic acid (MPA), and voriconazole N‐oxide (VCZ N‐oxide) for in vitro investigations. In this report, we present in vitro screening of these candidates and of voriconazole (VCZ) to assess their potential to be substrates and/or inhibitors of UGT2B10. Enzyme kinetics experiments included recombinant UGT2B10 and analytical methods based on ultra high‐performance liquid chromatography coupled to mass spectrometry (UHPLC–MS). To determine potential substrates, candidates were incubated at various therapeutically observed concentrations with recombinant UGT2B10 to identify the corresponding glucuronide metabolite. Inhibition capacity was tested using the selective probe cotinine for its glucuronidation to cotinine N‐ß‐d‐glucuronide. IC50 was determined for compounds exhibiting inhibition. Among the tested compounds, LOR (IC50 = 0.01 μM, R2 = 0.9257) and MPA (IC50 = 0.38 mM, R2 = 0.9212) exhibited inhibition potential for UGT2B10. None of the other tested compounds featured inhibition potential and none of the compounds tested exhibited metabolism through UGT2B10. Further exploration on the clinical relevance of this inhibition using modeling strategies, overlapping nature with other UGT isoforms, and screening other molecules for their inhibition potential on UGT2B10 is warranted.
Uptake and translocation of pesticides in pepper and tomato plants
Authors: Rein Arno , Trapp Stefan , Fantke Peter , Yalçın Melis , Turgut Nalan , Ahat Cansu , Camcı Elif , Turgut Cafer 
Published: November 2024

AbstractBACKGROUNDIn this study, field and greenhouse experiments were done with spray application of the insecticides acetamiprid, indoxacarb, deltamethrin, λ‐cyhalothrin, spinosad, chlorantraniliprole on pepper and tomato plants. Results were interpreted with numerical modeling.RESULTSObserved fruit concentration dynamics could be described overall well by modeling. After application, concentrations decreased in pepper and (slower) in tomato fruits (lower degradation and dissipation for tomato). Chemical input to individual above‐ground compartments (fruit, leaf, stem, soil), arising from spray, was among the unknowns and hence estimated. Input to fruits was estimated 1–13% and 1–17% of the total applied amount; input to stem, leaf and/or soil 0–13% and 0–26% (pepper and tomato). Input showed high variation across compounds, with considerable uncertainty due to a partly low sensitivity of stem/leaf/soil input to fruit concentrations. The pathway stem‐fruit was relevant for all compounds except λ‐cyhalothrin (pepper, tomato) and deltamethrin (tomato). The pathways soil‐root‐stem‐fruit and leaf‐stem‐fruit (phloem) were only sensitive for acetamiprid and chlorantraniliprole.CONCLUSIONThe dynamic model approach, implementing the appearance and growth of individual fruits, was after calibration successful in describing insecticide fate in pepper and tomato plants. Special consideration was given to dynamic modelling of plant growth and connected xylem and phloem flow. The dynamic approach was superior to assuming constant plant mass and transpiration, where growth dilution is described by rate constants. Information on the time‐window of experiments within the vegetation period and on the number and appearance of individual fruits is important for adequately describing growth and thus chemical fate within plants. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Bdyof is a Y‐chromosome‐specific gene required for male development in Bactrocera dorsalis
Authors: Zhang Qiuyuan , Chen Hao , Li Ziniu , Qiao Jiao , Liu Peipei , Zheng Chenjun , Deng Zhurong , Li Xiaoxue , Zhang Hongyu 
Published: November 2024

AbstractBACKGROUNDIn many organisms, the Y chromosome contains important genes associated with sex determination and male reproductive development. However, there have been few studies of Y‐chromosome‐specific genes in non‐model species due to the incomplete information of Y chromosome genome and difficulty in sequencing. Here, we screened 90 candidate Y‐specific sequences in a constructed transcriptome assembly library by using the chromosome quotient method, among which 11 were unreported sequences associated with male reproductive development, including Bactrocera dorsalis Y‐specific Oligozoospermia factor (Bdyof) with the highest expression in the testis.RESULTSCRISPR/Cas9‐mediated knockout of Bdyof resulted in abnormal testis development, significantly reduced sperm count, and obviously lower egg hatching rate in homozygous mutant flies. In addition, Bdyof knockout decreased the expression of dsx‐M.CONCLUSIONThis results provides new insights into the biological processes related to male reproductive development controlled by the Y‐chromosome‐specific gene Bdyof, thus providing a promising molecular target for the study of agricultural pests. © 2024 Society of Chemical Industry.
Theaflavins Applications to Ameliorate Implant Failure and Eradicate Microbial Infections and Foodborne Pathogens: A Comprehensive Review
Authors: Alavi Mehran , Pedro Sónia N. , Freire Mara G. , Ashengroph Morahem , Khan Haroon 
Published: November 2024

ABSTRACTTheaflavins, powerful antioxidants found in black tea (
Camellia sinensis
), have garnered increasing interest for their promising therapeutic potential. Experimental studies have contributed to enlightening about the advantages of theaflavins, including their antioxidant, anti‐inflammatory, anticancer, antiosteoporosis, and antimicrobial properties. Theaflavin and its derivatives, particularly theaflavin‐3,3′‐digallate, have been particularly noted for their enhanced action in different areas. These compounds have found an important role as alternatives or adjuvants in the pharmaceutical sector, food industry, and in the improvement of health conditions. This review focuses on the antioxidant and anti‐inflammatory aspects of theaflavins, particularly their potential in addressing peri‐implant osteolysis. We explore mechanisms and pathways involved in this therapeutic action. Furthermore, we cover some of the relevant studies on the antimicrobial action of theaflavins in both the health and food sectors. Specifically, we explore the use of theaflavins for the treatment of dental infections, where these compounds have shown particular efficacy against several bacterial strains and their antimicrobial application in food matrices. Given the low solubility and stability of theaflavins in physiological conditions, we emphasize the benefits of the development of biocompatible and biodegradable nanoformulations to enhance the stability, bioavailability, and efficacy of these polyphenols, to promote their broader research and application. Given the potential demonstrated so far by in vitro and in vivo studies, the application of theaflavins stands as a promising alternative to enhance the existing strategies and fight prosthetic failure and antimicrobial resistance in the health and food sectors.
Automated Non‐Supervised Eye Disorder Screening System Using Virtual Reality
Authors: Chen Lijing , Miao Yinan , Nam Hyeonwoo , Heo Hwan , Park Sang Woo , Park Gyuhae 
Published: November 2024

ABSTRACTBackgroundNeglecting eye disorders can lead to visual impairment or even vision loss, making early diagnosis and medical treatment crucial. This paper presents the development of an automated non‐supervised eye disorder screening system that utilises Virtual Reality (VR) to provide a preliminary screening for common eye disorders.MethodsThe system integrates advanced pupil‐tracking techniques, image‐processing methods, and eye disorder screening algorithms into one package for comprehensive eye disorder monitoring, including a strabismus test, a pupil test, and a contrast sensitivity test. Patients can wear a VR headset and use a joystick to interact with the VR scenario.ResultsThe system is validated through experiments conducted on both healthy subjects and patients in hospitals, demonstrating an agreement rate exceeding 90% when compared to diagnoses by doctors.ConclusionsThe test results highlight its potential for real‐world applications, ultimately improving the accessibility of early screening for eye disorders and remote healthcare.
Sarcoidosis and COVID‐19 Vaccines: A Systematic Review of Case Reports and Case Series
Authors: Al‐omoush Omar , Khalil Leen , Ramadan Alaa , Tarakhan Husam , Alzoubi Ahmad , Nabil Abdallah , Hajali Momen , Abdelazeem Basel , Saleh Othman 
Published: November 2024

ABSTRACTCOVID‐19 vaccines play a crucial role in preventing complications and alleviating the impact of SARS‐CoV‐2. Nevertheless, these vaccines have been associated with side effects like pain, fatigue, fever, and, in rare instances, the development of sarcoidosis. This review seeks to provide an overview of research on sarcoidosis occurring after COVID‐19 vaccination and attempt to identify potential factors that may contribute to this uncommon yet concerning complication. Our review protocol was registered on PROSPERO with ID: (CRD42023463854). We comprehensively searched five electronic databases (PubMed, Scopus, Web of Science, EMBASE, Cochrane) from August, 22 2023 until September, 1st 2023. We finally had 12 studies after the first and second scans. We used SPSS to analyse the extracted data. We included 31 participants who experienced lung sarcoidosis following COVID‐19 vaccination, with 61.3% female, and 38.7% male. The study showed that most events were observed in individuals who got Pfizer‐BioNTech or Moderna vaccines, particularly after the second dosage. Pain, local erythema, ulceration or swelling at the injection site, fever, urticaria, pityriasiform rash, and erythema multiforme were some of the most common presenting symptoms. A biopsy was the major diagnostic method. Other modalities were used, including a complete blood count, CT scans, and X‐rays. Sarcoidosis has been shown in a limited number of individuals who got the COVID‐19 vaccination; however, it is unclear if the vaccine is directly responsible for this condition. However, the COVID‐19 vaccines are both safe and effective in preventing the disease, and the advantages of immunisation outweigh any potential risks.
Enhanced Safety‐Critical Control of Hypersonic Vehicles With Multiple Constraints
Authors: Lu Qingli , Sun Ruisheng , Lu Yu , Zhao Ri 
Published: November 2024

ABSTRACTThis paper proposes an enhanced safety‐critical control scheme for hypersonic vehicles (HSVs) with multiple constraints, where both safety constraints (e.g., actuator saturations and time‐varying angle‐of‐attack [AOA] limitation) and transient performance constraints are considered. In this scheme, the extended exponential control barrier function (EECBF) is constructed by incorporating extended states and robust terms to deal with time‐varying constraint boundaries and uncertainties simultaneously. An adaptive programming for optimal transient performance envelopes is conducted to make a trade‐off between safety and transient performance constraints. It is shown that the proposed scheme for HSVs can confine AOA to time‐varying safety boundaries in the presence of uncertainties while the velocity and height tracking errors can always maintain within the desired transient performance envelopes. Simulations and comparisons are provided to verify the effectiveness of our scheme.
How Do I Want to be Read? Embodied Autobiographical and Discoursal Selves in Preservice English Teachers' Feedback to High School Writers
Authors: Olinger Andrea R. , Heron‐Hruby Alison , Chisholm James S. , Dungan Braydon L. , Conn Hannah M. , Nitishin Julia P. 
Published: November 2024

AbstractResearch on writing pedagogy highlights effective feedback as dialogic and student‐centered. However, few studies have examined how preservice English teachers (PSETs) craft their feedback based on how they want their students to read them. Drawing on sociocultural approaches to writing, we examine the co‐construction of these “discoursal selves” by studying PSETs' talk and embodied actions during focus‐group conversations about their feedback to student writers. Data included videorecorded focus groups, transcripts, and written feedback. By navigating their life histories (“autobiographical selves”) and the identities they sought to convey in their feedback (“discoursal selves”), PSETs struggled to contend with their internalized grammarians while projecting a peer identity that was encouraging even when they offered critique. We argue that reflection with PSETs on how they want to be read can empower them to make intentional instructional choices.
The Structural Relations of Component Reading Comprehension Skills in Kiswahili: The Influence of Socio‐Economic Status and Home Literacy Environment
Authors: Wawire Brenda Aromu , Wawire Gorrety Nafula , Kiroro Francis 
Published: November 2024

AbstractThis research explores structural relations among the component skills of reading comprehension in Kiswahili. Furthermore, the study examines the relationship between socio‐economic status, home and school language use, and home literacy environment with Kiswahili reading outcomes. The study utilized secondary data from the baseline Tusome Literacy activity implemented in Kenya at scale from 2015 to 2022 by USAID, Research Triangle Institute in collaboration with the Ministry of Education Kenya and other partners. A three‐stage stratified sampling procedure was used to randomly select the schools and students from a sample frame compiled from multiple education databases of public formal and non‐formal schools in Kenya. The final sample comprised 4886 grade 1 and 2 learners who completed a battery of early grade literacy assessment in Kiswahili and a survey of the socio‐economic status (SES), home literacy environment (HLE), and school and home language use. We conducted a regression analysis to examine structural relations among the component skills of reading comprehension and the relationships between the SES, HLE, and early literacy skills. The findings indicate that the component skills are interconnected with the sub‐lexical skills, serving as the building block for the higher‐order skills. Letter sound knowledge, text reading fluency, and listening comprehension predict reading comprehension. Reading stories at home, reading aloud, and silent reading practice at school significantly influences reading outcomes. The mismatch between home and school language and low SES negatively impacts reading outcomes. These findings indicate that systematic and explicit instruction is critical in acquiring literacy skills, particularly for learners from disadvantaged backgrounds.