bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontline Treatment for Older Patients with Mantle Cell Lymphoma
Authors: Ye Haige , Desai Aakash , Zeng Dongfeng , Romaguera Jorge , Wang Michael L. 
Published: June 2018

AbstractThe natural history of mantle cell lymphoma (MCL) undergoing chemotherapy is a cyclical pattern of remission followed by recurrence of disease due to acquired chemotherapy resistance. The median age of the occurrence of MCL is 65 years, so half of the newly diagnosed MCL patients are considered “elderly.” The tolerance to long-term chemotherapy in elderly patients is decreased; hence, the response to frontline therapy used is of paramount importance. We hope that our review may guide clinicians in treating such populations in a more personalized and evidence-based manner.In the older patients with risk variables, frontline treatment is determined according to different body status of fit, unfit or compromised, and frail. In the fit patients, the pursuit of remission and prolongation of survival might currently justify the use of more intense and toxic therapies. For unfit or compromised older patients, disease control needs to be prioritized, maintaining a balance between the benefits and toxicities of the treatment. For frail patients, tolerance of treatment and minimizing myelotoxicity should be the primary focus. “Chemotherapy-free” regimens are likely to be considered as the first-line strategy for this population. On the other hand, in the older MCL population without risk variables, observation or “watch and wait” can prevent overtreatment. Furthermore, more clinical trials and research studies on novel agents and targeted therapies need to be translated into the general population to provide optimal treatment and to guide personalized treatment.Implications for PracticeThis review emphasizes the importance of frontline therapies for older MCL patients. MCL patients commonly experience a cyclical pattern of remission followed by recurrence of disease due to acquired chemotherapy resistance. As a special population, elderly patients have various comorbidities and decreased organ function, which may reduce the chances of undergoing treatment for recurrent disease. Thus, this older population of patients with MCL should be treated separately and exceptionally. So far, systematic reviews with regard to frontline treatment for older patients with MCL have not been encountered, but the hope is that this review may guide clinicians in treating such populations in a more personalized and evidence-based manner.
Bola que balança a rede humana [poesia/áudio]
Authors: Moreira Wagner 
Published: June 2018

Este poema foi gravado em estúdio pelo próprio autor e sonorizado por Fabiano Fonseca, num encontro primoroso, que o elevou ao patamar que merecia: um dos mais bem acabados de nossa literatura a dialogar com o futebol, tanto pela forma quanto pelo conteúdo. Áudio: https://soundcloud.com/user-530005952/wagner-moreira-bola-que-balanca-a-rede-humana.
O legado da Copa 2014 foi o riso [imagem]
Authors: Junior Alexandre 
Published: June 2018

Reprodução de 8 imagens do artista visual Alexandre Junior que se referem, de maneira bem-humorada (e irônica), à Copa do Mundo de 2014 no Brasil.Tamanho original dos desenhos: A2, 42cm (largura) por 59,4cm (altura).Material: Nankin, guache, acrílica, grafite, aquarela e marcadores. Alexandre Junior é um artista mineiro formado em Artes Visuais pela EBA-UFMG. Trabalha nas linguagens do Desenho, da Ilustração e dos Quadrinhos. Entre as suas principais exposições, destacam-se: Apenas mais um parabéns para você nesta data querida (2012), Nó (2012), Reis do Ringue (2013, 2014), Vigiar (2016), FLAC (2017) e Momento que passa, desenho que fica (2018).Em 2015, Alexandre lançou, no FIQ, Os Abestados, seu primeiro álbum solo de quadrinhos. Em 2016, foi convidado a participar do livro Sketchers do Brasil, uma coletânea de 51 artistas nacionais participantes do movimento "Urban Sketchers". Publicou os zines Anatomia de corpos que estudam e Movie Quotes Sketchbook, que fazem parte de um projeto de desenhar seus filmes preferidos.Os trabalhos de Alexandre são em sua maioria focados em pessoas. O artista já compôs séries sobre aniversários, lutas e, em um recorte mais intimista, sobre seu irmão no leito hospitalar. Seus desenhos são realizados em diferentes formatos e tamanhos, além de contarem com técnicas mistas.Site: https://www.alexandrejunior.net/
Functional Approach to Development of Hybrid Technology of Cutting Diamond Carbides
Authors: Salenko А.F. , Shchetinin V.Т. , Gabuzian G.V. , Nikitin V.А. , Klymenko S.А. , Potapov А.М. , Tanovic Lj. 
Published: June 2018

Background: Modern composite materials have a number of advantages in comparison with the traditionally used ones and allow implementing new methods of processing, which makes the finished product cheaper and makes its use more efficient.Objective: In order to improving the surface quality and productivity taken by A functional approach. Method: A functional approach to the development of cutting technologies for Carbide and Super Hard Multilayered Composites is considered. It allows, by alternating the effects of different nature, to obtain qualitative edges, to lower the residual stresses in the surface layers, and to achieve a high surface quality. The essence of the approach is that the method of impact is determined on the basis of a morphological search of options for the execution of individual surface elements, each of which, combined into a set, uniquely forms the function of the finished product. The cutting is determined by a rational sequence of execution of technological transitions, provided that each harmful intermediate function at the finish stage turns into neutral or complements the required useful function.Results: Examples of figured cutting of plates from polycrystalline diamond-containing materials are given, the results of obtaining qualitative edges are shown.Conclusion: Thanks to the proposed technology based on the use of a functionally oriented approach, the functions of the tool for cutting are divided between the tool itself and the product part. As a result, the processing speed increases more than 3 times, and a high cut quality is achieved.
Transition zone in Bearing Capacity Problem from Plasticity Method, Discrete Element Method and Laboratory tests
Authors: Cheng Yungming 
Published: June 2018

<p>In this paper, the classical bearing capacity problem and the logspiral transition zone are re-considered from a continuum plasticity approach as well as discrete element approach. In the discrete element approach, the bearing capacity problem is considered from the elastic stage, plastic stage to the final rupture stage. It is found that there are noticeable differences in the failure mechanism between the continuum and discontinuum analyses, and the well-known logspiral transition zone is also not apparent in both the discrete element approach, plasticity approach as well as the laboratory tests. With the increase in the friction angle of soil, the transition zone is becoming more like a wedge zone than a logspiral zone as found from the present study. </p>
Determination of Optimum Zn content in Cd1-xZnxS Nanoparticles
Authors: HOROZ Sabit , EKINCI Arzu , SAHIN Omer 
Published: June 2018

<p>CdZnS quantum dots (QDs) QDs containing concentrations of 0.25, 0.5, 1, 3 and 5% Zn were synthesized at room temperature by chemical precipitation method and then incident photons to current efficiency (IPCE) measurements were performed to determine optimum Zn concentration in CdZnS QDs. Moreover, Zn<sub>2</sub>SnO<sub>4</sub>, a ternary compound semiconductor, was used instead of TiO<sub>2</sub> as counter electrode for the first time. As a last part of the study, the structural and optical properties of CdZnS QDs containing optimum Zn content were investigated, respectively. Consequently, it appears that CdZnS QDs have a higher efficiency than CdS and that Zn doping plays an important role in this increase.</p>
Enhancing photoresponse by synergy of electric double layer gate and illumination in single CuTCNQ NW field effect transistors
Authors: Basori Rabaya 
Published: June 2018

<p class="BodyText1"><span lang="EN-IN">We report that photoresponse of </span><span lang="EN-US">a single metal-organic charge transfer complex Cu:TCNQ nanowire (NW)</span><span lang="EN-IN"> can be enhanced simultaneously by illumination as well as applying a gate bias in an Electric Double Layer Field Effect Transistor (EDL-FET) configuration fabricated on </span><span lang="EN-US">Cu:TCNQ </span><span lang="EN-IN">as a channel.</span><span lang="EN-IN">It is observed that applying a bias using an EDL gate to a n-channel Cu:TCNQ single NW FET, one can enhance the photoresponse of the Cu:TCNQ substantially over that which arise from the photoconductive response alone. </span><span lang="EN-US">Electron-hole pairs that generate in the NW under illuminated of wavelength 400nm gives rise photo current. Also, electric double layer induce negative charges in the NW channel which effectively increases the carrier concentration, contributing to better response in conduction. </span><span lang="EN-IN">The effect reported here has a generic nature that gives rise to a class of gated photodetectors of different photoresponsive materials.</span></p>
Implementing Relationship Banking Strategies and Techniques and Improving Customer Value
Authors: Guo Yongsheng 
Published: June 2018

<p>This paper identifies strategic concepts and practical techniques in relationship-banking andexploreshow customer value was improved and how relationship-bankingperformancewas measured and linked to relationship managers’ compensation. Grounded theory was adopted to collect and analyse data. 25 interviews have been conducted with relationship managers and corporate banking directors in 11 case banks and case banks’ quantitative data was used to support the propositions. It was found that customer relationship was seen as a valuable asset. Relationship Orientation and Customer Focus were evaluated by undertaking internal surveys and relationship management objectives were formulated and actions were proposed to improve Customer Value to the case banks. In the case banks Customer Information was collected through multiple customer touch points and integrated and analyzed.Customer Knowledge wasaccumulated and sustainable Competitive Advantages were built.Customer Perception and Customer Loyalty were measured externally.Customer Value and Risk Adjusted Return on Asset (RAROA) wereemployed to measure relationship banking performance and reward relationship managers accordingly. The interviewees perceived that relationship-banking performance could be improved in this dynamic learning process. </p>
The Influence Factors and International Comparison of Currency Crises under Abnormal Flow of Capital
Authors: He Yan 
Published: June 2018

<p class="16" align="justify"><span>The paper</span><span> </span><span>focused on improving</span><span> </span><span>the measurement methods about the scale of international capital flow and </span><span>put</span><span>ting</span><span> forward the </span><span>C</span><em><span>omprehensive </span></em><em><span>M</span></em><em><span>easuring </span></em><em><span>M</span></em><em><span>ethod</span></em><span> </span><span>by which to</span><span> </span><span>analyze</span><span> </span><span>and compare the </span><span>abnormal flow</span><span>s</span><span> of international capital of 11 countries in which currency crises occurred</span><span> by</span><span> the empirical test</span><span>s. In addition, t</span><span>he </span><span>author</span><span> </span><span>studied the influence factors and ways of abnormal flow of capital from three aspects, and tried to provide scientific early-warning tool and countermeasures for preventing currency crises.</span></p>
Research On The Integration And Development Of "Internet Plus" And Logistics
Authors: Zhao Yanhong 
Published: June 2018

<p>The logistics industry plays an important role as a pillar industry in the national economy. As a new communication technology, "Internet +" and the integration of the logistics industry will create a good foundation for the transformation and upgrading of the logistics industry with its advanced development concepts and models, the logistics industry is booming. Therefore, the country should attach great importance to promote the progress of China's logistics industry. Based on the idea of "Internet Plus" and the integration of the logistics industry, this article elaborates the countermeasures for promoting the development of the integration of the "Internet +" and the logistics industry for reference</p>
Fixation Options Following Greater Trochanteric Osteotomies and Fractures in Total Hip Arthroplasty
Authors: Mei Xin Y. , Gong Ying Jia , Safir Oleg A. , Gross Allan E. , Kuzyk Paul R. 
Published: June 2018

Background:
The optimal system for greater trochanteric fixation following osteotomy or fracture remains unknown. This systematic review aims to synthesize the available English-language literature on 5 commonly reported trochanteric fixation methods to quantify and compare rates of complications and reoperation.

Methods:
A comprehensive search of MEDLINE and Embase databases from January 1946 to June 2017 was performed for articles in English describing fixation of trochanteric osteotomies and fractures using wires, cables, cable-plate devices, claw or locking plates, and trochanteric bolts. Pooled mean rates of complications and reoperation with 95% confidence intervals (CIs) were analyzed using a random-effects model.

Results:
Fifty-seven studies involving 10,956 hips were eligible for inclusion. Five studies had Level-III evidence and 52 had Level-IV evidence. The pooled mean rate of nonunion was 4.17% (95% CI, 3.21% to 5.13%; I2 = 79%) for wires, 5.07% (95% CI, 0.37% to 9.77%; I2 = 74%) for cables, 16.11% (95% CI, 10.85% to 21.37%; I2 = 89%) for cable-plate systems, 9.60% (95% CI, 2.23% to 16.97%; I2 = 59%) for claw or locking plates, and 12.42% (95% CI, 3.41% to 21.43%; I2 = 75%) for trochanteric bolts. Substantial heterogeneity in the data precluded formal statistical comparison of outcomes and complications between implants.

Conclusions:
Available literature on the various trochanteric fixation implants is heterogeneous and consists primarily of retrospective case series. Based on the current literature, it is difficult to support the use of one implant over another. Despite superior mechanical properties, rates of complication and reoperation following cable-plate fixation remains suboptimal, especially in complex revision scenarios. Additional rigorous prospective randomized and cohort studies are needed to make definitive recommendations regarding the most reliable method of trochanteric fixation.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Competitive Advantages of Small Medium Industry on the Islands in Indonesian Context
Authors: Kurniawan Muslim El Hakim , Yudoko Gatot , Basri Mursyid Hasan 
Published: June 2018

Indonesian Law No.3/2014 regarding Industry requires both Central and Local Governments to realize the competitiveness of small and medium industries. However, the fact that the condition of each region is not similar becomes a main problem. It is because Indonesia is an archipelagic country. The competitiveness index of Asia Competitiveness Institute 2015 indicates that islands provinces, such as Kepulauan Bangka Belitung, Nusa Tenggara Barat, Nusa Tenggara Timur, Sulawesi Utara, Maluku, Maluku Utara, Sulawesi Tenggara, need specific development strategies. They cannot be equated with the mainlands, such as Java and Sumatera, because their competitiveness rank is very low. A review of literature on the competitiveness of islands entrepreneurs shows that from the 4 (four) schools of thought in competitive advantage, only few researchers have pertained on the knowledge based on the schools of thought. Therefore, this could be a future research opportunity.
Development of platinum supported on single-walled carbon nanotubes by deposition-precipitation for microbial fuel cells
Authors: Pusomjit P. , Chailapakul O. , Ng H. Y. , Thepsuparungsikul N. 
Published: June 2018

Abstract
Microbial fuel cells (MFCs) are an ecologically friendly technology that can recover electricity and simultaneously treat wastewater. Among all the influential factors, cathode material and catalyst play a crucial role in electricity production and oxygen reduction. In this study, Pt nanocatalysts deposited on single-walled carbon nanotubes (Pt/SWCNTs) were synthesized by the deposition-precipitation (DP) method under optimal conditions. The results show that DP might be a promising method for the preparation of Pt/SWCNTs due to its simple, cost-effective and time-saving procedure, in addition to being highly efficient at creating small Pt particles (0.9 nm) that were very uniformly distributed. The synthesized Pt/SWCNTs suspension was spray-coated on to carbon cloth and then used as a cathode for MFCs. The electricity generation of MFCs equipped with a Pt/SWCNTs cathode was evaluated in terms of open circuit voltage (0.6954 V), internal resistance (63.3 Ω•m2) and maximum power density (2,022 mW/m2). The chemical oxygen demand removal, biological oxygen demand removal, total dissolved solids removal, total suspended solids removal and silver recovery was satisfactory at 84.5%, 74.0%, 45.7%, 60.0% and 99.0%, respectively. Therefore, Pt/SWCNTs from the DP method was identified as a potential candidate to replace commercial Pt-carbon cloth for MFC cathodes.
A Pilot Study of Plasma Antipsychotic Drugs Concentrations of First Episode Patients with Psychosis From Epirus - Greece
Authors: Boumba Vassiliki A. , Petrikis Petros , Patteet Lisbeth , Baou Maria , Rallis Georgios , Metsios Apostolos , Karampas Andreas , Maudens Kristof , Mavreas Venetsanos 
Published: June 2018

Background:
This contribution is a study on plasma antipsychotics concentrations
of first episode outpatients with psychosis (FEPs), under antipsychotic treatment; it aims to
attract attention to the importance of the drug-driven management of psychiatric patients for
improving adherence and clinical efficacy.

Methods:
The plasma antipsychotic concentrations were determined retrospectively (after the
completion of selection of all samples) and therefore, they were not used to monitor patients’
response to pharmacotherapy. A total of 120 plasma samples from 35 psychiatric patients
were collected and tested for antipsychotics. The concentrations of eight antipsychotic drugs
(amisulpride, aripiprazole, clozapine, haloperidol, olanzapine, quetiapine, risperidone and
paliperidone) and seven of their metabolites were determined.

Results:
Overall, 74% of the samples had therapeutic antipsychotic levels, 19% had subtherapeutic
concentrations, while supra-therapeutic concentrations were measured for clozapine
(7%). Therapeutic drug concentrations were recorded in 54% of plasma samples from patients
being under olanzapine medication and in all patients under long-acting injectables.
Sub-therapeutic levels were either attributed to non-adherence, or they reflected residual levels
due to medication changes. Supra-therapeutic levels were recorded for clozapine and were
not followed by adverse effects.

Conclusion:
This is the first study on antipsychotic plasma levels conducted in Greece. Our
results show the importance of performing measurement of plasma antipsychotics levels, at
appropriate time intervals, for improving adherence, clinical decision making and thus clinical
efficacy. Especially for FEPs, such approach could contribute to early detection of treatment
limitations and improve outcome.
Health Care Spending on Diabetes in the U.S., 1996–2013
Authors: Squires Ellen , Duber Herbert , Campbell Madeline , Cao Jackie , Chapin Abigail , Horst Cody , Li Zhiyin , Matyasz Taylor , Reynolds Alex , Hirsch Irl B. , Dieleman Joseph L. 
Published: June 2018

OBJECTIVE
Health care spending on diabetes in the U.S. has increased dramatically over the past several decades. This research describes health care spending on diabetes to quantify how that spending has changed from 1996 to 2013 and to determine what drivers are increasing spending.

RESEARCH DESIGN AND METHODS
Spending estimates were extracted from the Institute for Health Metrics and Evaluation’s Disease Expenditure 2013 database. Estimates were produced for each year from 1996 to 2013 for each of 38 age and sex groups and six types of care. Data on disease burden were extracted from the Global Burden of Disease 2016 study. We analyzed the drivers of spending by measuring the impact of population growth and aging and changes in diabetes prevalence, service utilization, and spending per encounter.

RESULTS
Spending on diabetes in the U.S. increased from $37 billion (95% uncertainty interval $32–$42 billion) in 1996 to $101 billion ($97–$107 billion) in 2013. The greatest amount of health care spending on diabetes in 2013 occurred in prescribed retail pharmaceuticals (57.6% [53.8–62.1%] of spending growth) followed by ambulatory care (23.5% [21.7–25.7%]). Between 1996 and 2013, pharmaceutical spending increased by 327.0% (222.9–456.6%). This increase can be attributed to changes in demography, increased disease prevalence, increased service utilization, and, especially, increases in spending per encounter, which increased pharmaceutical spending by 144.0% (87.3–197.3%) between 1996 and 2013.

CONCLUSIONS
Health care spending on diabetes in the U.S. has increased, and spending per encounter has been the biggest driver. This information can help policy makers who are attempting to control future spending on diabetes.
Looking through the Corners
Authors: Almeida Tiago Santos 
Published: June 2018

This paper presents the role of Althusser and two of his students in the 1960s, Pierre Macherey and Dominique Lecourt, in the diffusion of the work of Georges Canguilhem in Brazil. We begin by a brief review of Macherey’s and Lecourt’s analysis on the work of Canguilhem taken from two texts that served as postface and preface to the Brazilian and the Argentine translations of Le normal et le pathologique. Next, we present the works ofBrazilian authors Sérgio Arouca, Cecilia Donnangelo and Ricardo Bruno Mendes-Gonçalves to show some aspects of the reception of Canguilhem’s ideas and concepts in the field of Collective Health.