bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide profiling of microRNAs and prediction of mRNA targets in 17 bovine tissues
Authors: Wang Min , Chamberlain Amanda J , Prowse-Wilkins Claire P , Vander Jagt Christy J , Hancock Timothy P , Pryce Jennie E , Cocks Benjamin G , Goddard Mike E , Hayes Benjamin J 
Published: March 2019

AbstractMicroRNAs regulate many eukaryotic biological processes in a temporal- and spatial-specific manner. Yet in cattle it is not fully known which microRNAs are expressed in each tissue, which genes they regulate, or which sites a given microRNA bind to within messenger RNAs. An improved annotation of tissue-specific microRNA network may in the future assist with the identification of causal variants affecting complex traits. Here, we report findings from analysing short RNA sequence from 17 tissues from a single lactating dairy cow. Using miRDeep2, we identified 699 expressed mature microRNA sequences. Using TargetScan, known (60%) and novel (40%) microRNAs were predicted to interact with 780,481 sites in bovine messenger RNAs homologous with human. Putative interactions between microRNA families and targets were significantly enriched for interactions from previous experimental and computational identification. Characterizing features of microRNAs and targets, we showed that (1) mature microRNAs derived from different arms of the same precursor targeted different genes in different tissues; (2) miRNA target sites preferentially occurred within gene regions marked with active histone modification; (3) variants within microRNAs and targets had lower allele frequencies than variants across the genome, as identified from 65 million whole genome sequence variants; (4) no significant correlation was found between the abundance of microRNAs and messenger RNAs differentially expressed in the same tissue; (5) microRNAs and target sites weren’t significantly associated with allelic imbalance of gene targets. This study contributes to the goals of Functional Annotation of Animal Genomes consortium to improve the annotation of genomes of domestic animals.
Is microbial activity in tropical forests limited by phosphorus availability? Evidence from a tropical forest in China
Authors: Mori Taiki , Lu Xiankai , Wang Cong , Mao Qinggong , Wang Senhao , Zhang Wei , Mo Jiangming 
Published: March 2019

AbstractThe prevailing paradigm for soil microbial activity in tropical forests is that microbial activity is limited by phosphorus (P) availability. Thus, exogenous P addition should increase rates of organic matter decomposition. Studies have also confirmed that soil respiration is accelerated when P is added experimentally. However, we hypothesize that the increased rates of soil microbial respiration could be due to the release of organic material from the surface of soil minerals when P is added, because P is more successful at binding to soil particles than organic compounds. In this study, we demonstrate that P addition to soil is associated with significantly higher dissolved organic carbon (DOC) content in a tropical evergreen forest in southern China. Our results indicate that P fertilization stimulated soil respiration but suppressed litter decomposition. Results from a second sorption experiment revealed that the recovery ratio of added DOC in the soil of a plot fertilized with P for 9 years was larger than the ratio in the soil of a non-fertilized plot, although the difference was small. We also conducted a literature review on the effects of P fertilization on the decomposition rates of litter and soil organic matter at our study site. Previous studies have consistently reported that P addition led to higher response ratios of soil microbial respiration than litter decomposition. Therefore, experiments based on P addition cannot be used to test whether microbial activity is P-limited in tropical forest soils, because organic carbon desorption occurs when P is added. Our findings suggest that the prevailing paradigm on the relationship between P and microbial activity in tropical forest soils should be re-evaluated.
Establishment of an orthodontic retention mouse model and the effect of anti-c-Fms antibody on orthodontic relapse
Authors: Qi Jiawei , Kitaura Hideki , Shen Wei-Ren , Kishikawa Akiko , Ogawa Saika , Ohori Fumitoshi , Noguchi Takahiro , Marahleh Aseel , Nara Yasuhiko , Mizoguchi Itaru 
Published: March 2019

AbstractOrthodontic relapse after orthodontic treatment is a major clinical issue in the dental field. However, the biological mechanism of orthodontic relapse is still unclear. This study aimed to establish a mouse model of orthodontic retention to examine how retention affects the rate and the amount of orthodontic relapse. We also sought to examine the role of osteoclastogenesis in relapse using an antibody to block the activity of M-CSF, an essential factor of osteoclast formation. Mice were treated with a nickel-titanium closed-coil spring that was fixed between the upper incisors and the upper-left first molar to move the first molar in a mesial direction over 12 days. Mice were randomly divided into three groups: group 1, no retention (G1); group 2, retention for 2 weeks (G2); and group 3, retention for 4 weeks (G3). In G2 and G3, a light-cured resin was placed in the space between the first and second molars as a model of retention. Orthodontic relapse was assessed by measuring changes in the dimensions of the gap created between the first and second molars. To assess the activity and role of osteoclasts, mice in G3 were injected with anti-c-Fms antibody or PBS, and assessed for changes in relapse distance and rate. Overall, we found that a longer retention period was associated with a slower rate of relapse and a shorter overall amount of relapse. In addition, inhibiting osteoclast formation using the anti-c-Fms antibody also reduced orthodontic relapse. These results suggest that M-CSF and/or its receptor could be potential therapeutic targets in the prevention and treatment of orthodontic relapse.
Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: a cross-sectional study
Authors: Sánchez-Rodríguez Martha A. , Zacarías-Flores Mariano , Arronte-Rosales Alicia , Mendoza-Núñez Víctor Manuel 
Published: March 2019

AbstractObjectiveTo assess the association between hot flashes (HFs) severity and oxidative stress (OS) in Mexican postmenopausal women.MethodsA cross-sectional study was carried out with perimenopausal women aged 40-59 years community-dwelling from Mexico City, Mexico. They participated in Menopause and Oxidative Stress Project. The baseline sample consisted of 476 women recruited to participate; 161 women were excluded due to different reasons. Hence, 315 women were selected to establish two groups, a) 145 premenopausal women (yet with menstrual bleeding), and b) 170 postmenopausal women (without menses). All women were free of cardiovascular, kidney, hepatic or cancer disease, and without antioxidant supplement intake for at least six months prior to the beginning of the study; none had previously received hormone therapy. As OS markers, we measured plasma malondialdehyde using the TBARS assay, erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx), uric acid, and total antioxidant status; also, we calculated SOD/GPx ratio, antioxidant gap and an oxidative stress score ranging from 0 to 7. The HFs were evaluated using the Menopause Rating Scale. The women completed Spanish version of the Athens Insomnia Scale, Zung Self-Rating Anxiety Scale and Zung Self-Rating Depression Scale and a questionnaire of pro-oxidant factors.ResultsStress score increased with HFs severity (mild 2.9±0.23, moderate 3.1±0.21 and severe 3.8±0.18, p<0.01) in postmenopausal women. We observed a positive correlation between HFs severity and stress score, r=0.247 (p=0.001) in postmenopausal women; other test scores were not correlated. Severe HFs were a risk factor for OS (OR=3.37, 95%CI: 1.20-9.51, p<0.05) in an adjusted multivariate analysis by different postmenopausal symptoms and pro-oxidant factors; we did not see any association in premenopausal women.ConclusionOur findings suggest an association between HFs severity and OS in Mexican postmenopausal women.
An approach to generating the sequence of part variant design based on information transfer utility
Authors: Xu Xinsheng , Lin Jing , Xiao Ying , Yu Jianzhe , Liu Qing , Geng Jie 
Published: March 2019

Purpose
Product variant design can only be achieved after all its constituent parts have been implemented by variant design. It is necessary to plan the sequence of part variant design reasonably. The product variant design process involves a large amount of information transfer events at the dimensional level. A reasonable product variant design process needs to make full use of the information transfer characters of parts to decrease the uncertainty of product variant design process. The existing methods of researching the product variant design process mainly focus on resource constraint and activity logic. They are deficient, however, in information transfer resolution and uncertainty management. This paper aims to address these issues.

Design/methodology/approach
This paper identifies the number of dimension transfer paths and the position of dimension locating within a transfer path as being the key factors affecting the information transfer role of dimension. Information transfer utility is proposed to measure the information transfer capability of dimensions and parts. Based on these, a two-stage approach of generating the sequence of part variant design based on information transfer utility is proposed.

Findings
The uncertainty of dimension constraint network is minimal during the product variant design process when parts are implemented by variant design under the sequence generated through a two-stage method based on the information transfer utilities of parts, as does the times of parameter transferring and iteration in dimension constraint network.

Originality/value
Part variant design under the sequence of descending information transferring utilities can decrease the difficulty of implementing product variant design validly and also increase the efficiency. This suggests an innovative method to planning the product variant design process reasonably from the perspective of informatics.
Robust task-space tracking for free-floating space manipulators by cerebellar model articulation controller
Authors: Li Liang , Chen Ziyu , Wang Yaobing , Zhang Xiaodong , Wang Ningfei 
Published: March 2019

Purpose
The purpose of this paper is to solve the tracking problem for free-floating space manipulators (FFSMs) in task space with parameter uncertainties and external disturbance.

Design/methodology/approach
In this paper, the novel cerebellar model articulation controller (CMAC) is designed with the feedback controller. More precisely, the parameter uncertainties in the FFSM are considered for achieving the robustness.

Findings
By using the dynamically equivalent model, the CMAC can be designed and trained with the desired performance, such that the prescribed trajectory can be followed accordingly. The simulation results are presented for illustrating the validity of the derived results.

Originality/value
Based on the designed CMAC, the tracking error would be approaching zero by choosing appropriate quantization level in CMAC and the corresponding learning rules can be tuned online.
Impact of training in Autism on inclusive practices
Authors: Nolan Amy Dympna , Hannah Elizabeth Fraser Selkirk 
Published: March 2019

Purpose
The purpose of this paper is to evaluate the impact of training on educational staff attitudes, sentiments, concerns and efficacy in providing support for children with Autism in mainstream settings.

Design/methodology/approach
The investigation adopted a pre-test/post-test, quasi-experimental, within-subject research design. In total, 35 early years educators, teachers and pupil support assistants from one Scottish Local Authority (LA) undertook training delivered by the LA’s Communication and Language Outreach Service. Measures included the Sentiments, Attitudes, and Concerns about Inclusive Education Revised (SACIE-R) scale and the teacher efficacy for inclusive practices (TEIP) scale pre and post-training. Post-training participants completed a questionnaire employing open and closed questions to assess perceived usefulness of training, application of knowledge and effectiveness of the teaching strategies.

Findings
Combining data from the three sectors there was a significant change in staff efficacy for inclusive practices (z=−3.406, p=0.001, p<0.05, with a medium effect size r=0.41) although there were differences between the sectors. There was a significant change in SACIE-R total scores (z=−3.945, p=0.000, p<0.05; with a medium effect size r=0.47), sentiments (z=−2.763, p=0.006, p<0.05; with a medium effect size r=0.33) and concerns (z=−3.685, p=0.000, p<0.05; with a medium effect size of r=0.44) subscale scores for the combined sector data. There was no significant change in the attitudes subscale scores for the combined sector data (z=−1.106, p=2.69, p>0.05; with a small effect size r=0.13) although there were differences between the sectors.

Research limitations/implications
Limitations include: small sample size, minor differences in the training in different sectors, purposeful sampling, use of questionnaire post-training, variability of completion of SCAIE-R and TEIP post-training.

Originality/value
There appears to be limited research into inclusive practices for children with Autism in the UK context, which this study aims to address.
A theory of enterprise risk management
Authors: Jankensgård Håkan 
Published: March 2019

Purpose
The purpose of this paper is to develop a theory of enterprise risk management (ERM).

Design/methodology/approach
The method is to develop a theory for ERM based on identifying the general risk management problems that it is supposed to solve and to apply the principle of deduction based on these premises.

Findings
ERM consists of risk governance, which is a set of mechanisms that deals with the agency problem of risk management and risk aggregation, which is a set of mechanisms that deals with the information problem of risk management.

Research limitations/implications
The theory, by identifying the central role of the Board of Directors, encourages further research into the capabilities and incentives of directors as determinants of ERM adoption. It also encourages research into how ERM adoption depends on proxies for agency problems of risk management, such as a decentralized company structure.

Practical implications
The theory encourages Boards of Directors to focus on understanding where the under and over management of risk are likely to be greatest, as opposed to the current practice of mapping a large number of risk factors.

Originality/value
The theory complements existing theory on corporate risk management, which revolves around the role of external frictions, by focusing on internal frictions in the firm that prevent effective risk management. It is the first work to delineate ERM vis-a-vis existing risk theory.
Influence strategies and work outcomes: effects of attributions
Authors: Chong Melody P.M. , Zhu Xiji , Fu Pingping , Wong Ling Ying Sarinna 
Published: March 2019

Purpose
Previous research on influence strategies has almost exclusively indicated negative relationships between assertive influence and employee work outcomes; the purpose of this study is to argue that an assertive influence strategy can also lead to both positive and negative work outcomes, when subordinates hold different attributions towards the leaders’ motive of using assertive influence (hereafter “the cause”).

Design/methodology/approach
The empirical study was based on data collected from 930 employees in China. The authors developed hypotheses to test the mediating effects of three types of perception in the relationship between an assertive influence strategy and five outcomes, and additional analyses on persuasive and relational influence strategies are also conducted.

Findings
Results show that when subordinates attribute the cause to their ability (internal attribution), an assertive influence has indirect positive effect on felt obligation, organizational commitment, job performance and organizational citizenship behavior; when subordinates attribute the cause to the poor relationship with their superiors (relational attribution), an assertive influence has indirect negative impact on most outcomes except for job performance; when subordinates perceive that the cause is to the superiors, such as authoritarian leadership (external attribution), an assertive influence has indirect positive effect on job performance.

Practical implications
The study highlights the importance of subordinates’ perceptions during the leadership influence processes.

Originality/value
This study was the first to examine the mediation relationship between three types of influence strategies and five organizational outcomes based on a large sample of front-line staff in China. The findings of the study also enrich the literature of leadership and attribution theories.
Job crafting and well-being in the elderly care sector: the effect of over-commitment
Authors: Romeo Marina , Yepes-Baldó Montserrat , Piñeiro Miguel Ángel , Westerberg Kristina , Nordin Maria 
Published: March 2019

Purpose
The purpose of this paper is to analyze the moderation effect of over-commitment in the job crafting–well-being relationship, in the elderly care sector in Spain.

Design/methodology/approach
A cross-sectional design was implemented and a final sample of 353 participants were assessed using the Job Crafting Questionnaire, an adaptation of the Over-commitment Scale from the Effort-Reward Imbalance Questionnaire, and the General Health Questionnaire (GHQ-12).

Findings
A positive interaction between relational and task crafting and over-commitment is observed in the prediction of well-being levels. Specifically, the effect of over-commitment in the task crafting–well-being relationship proved to be statistically significant when opposed to low, medium and high levels of over-commitment. Additionally, the effect of over-commitment in the relational crafting–well-being relationship proved to be statistically significant only when opposed to medium and high levels of over-commitment. Finally, a direct and simple effect was observed between cognitive crafting and well-being, not moderated by over-commitment.

Research limitations/implications
Implementation of non-behavioral measurements, and a non-longitudinal design are suggested. The development of behavioral measures for job crafting is encouraged, along with the implementation of longitudinal designs sensitive to changes in over-commitment. Possible over-commitment results are biased by an economically contracted environment.

Practical implications
Job crafting training, over-commitment early detection and further research on job crafting strategies’ preferences are suggested.

Originality/value
The moderating role of over-commitment in the job crafting–well-being relationship in the elderly care sector represents one of these attempts to better understand evidences of how work-related efforts modify a worker’s psychological functioning and adaptation, which is the reason why, specially in contexts of uncertainty, its study becomes relevant.
Women’s leadership and gendered experiences in tech cities
Authors: Hardey Mariann 
Published: March 2019

Purpose
The purpose of this paper is to examine the findings from longitudinal study conducted with women leaders in tech cities to understand the cultural and discursive burden affecting their professional experiences and the dominant cultural boundaries they regularly have to cross to legitimise their knowledge and expertise.

Design/methodology/approach
The paper draws on research from the Gender in Tech City project that included serial interviews with 50 senior women leaders over three years at three different tech city sites.

Findings
The paper illustrates the differing spatialities that women continue to face within tech culture and how terms such as “women in tech” are problematic.

Research limitations/implications
This study adds to the conceptualisation of tech culture and gendered constructions within a spatial context; there is a need to strengthen this path of investigation beyond gender as a lone issue.

Originality/value
The study contributes to the literature on spatial context, examining a new micro-context within tech culture that amplifies hidden biases and restricts the movement of women professionals.
Orchestration of dynamic capabilities for competitive advantage
Authors: Brink Tove 
Published: March 2019

Purpose
This paper aims to shed light on how offshore wind park business networks can orchestrate dynamic capabilities to enable innovation for the competitive advantage of renewable offshore wind energy.

Design/methodology/approach
The research is based on a qualitative multiple-case study of operation and maintenance activities in offshore wind parks, starting in June 2014 with a pilot qualitative case study and the main qualitative multiple-case research conducted via in-depth interviews with 20 enterprises. The preliminary findings were presented for the qualitative triangulation of comments in a seminar in May 2015.

Findings
The findings explain the need for collaboration across the business network through the use of an open innovation platform for orchestrating dynamic signature capabilities in combination with ordinary capabilities. Both locally distributed leadership and central leadership in knowledge creation are necessary ingredients. The model developed from the research findings shows the need to change the competitive advantage criteria within business networks to VRIS (valuable, rare, imitable, substitutable) in contrast to the traditional criteria for individual enterprises of VRIN (valuable, rare, imperfectly imitable, non-substitutable).

Research limitations/implications
The research is focused on offshore wind park business networks, and therefore, the generalizability of this qualitative case study to other contexts can be limited. Further research is thus needed to verify the findings.

Originality/value
A three-fold contribution is made to the understanding of the integrated combination of orchestrating dynamic capabilities in the offshore wind energy sector. Business networks, academia and policy bodies are given a model for enacting the competitive advantage of renewable offshore wind energy for the benefit of society.