bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing patient satisfaction after adult scoliosis and spinal deformity surgery
Authors: Hayashi Kazunori , Boissière Louis , Guevara-Villazón Fernando , Larrieu Daniel , Núñez-Pereira Susana , Bourghli Anouar , Gille Olivier , Vital Jean-Marc , Pellisé Ferran , Sánchez Pérez-Grueso Francisco Javier , Kleinstück Frank , Acaroğlu Emre , Alanay Ahmet , Obeid Ibrahim 
Published: May 2019

OBJECTIVEAchieving high patient satisfaction with management is often one of the goals after adult spinal deformity (ASD) surgery. However, literature on associated factors and their correlations with patient satisfaction is limited. The aim of this study was to determine the clinical and radiographic factors independently correlated with patient satisfaction in terms of management at 2 years after surgery.METHODSA multicenter prospective database of ASD surgery was retrospectively reviewed. The demographics, complications, health-related quality of life (HRQOL) subdomains, and radiographic parameters were examined to determine their correlation coefficients with the Scoliosis Research Society-22 questionnaire (SRS-22R) satisfaction scores at 2 years (Sat-2y score). Subsequently, factors determined to be independently associated with low satisfaction (Sat-2y score ≤ 4.0) were used to construct 2 types of multivariate models: one with 2-year data and the other with improvement (score at 2 years − score at baseline) data.RESULTSA total of 422 patients who underwent ASD surgery (mean age 53.1 years) were enrolled. All HRQOL subdomains and several coronal and sagittal radiographic parameters had significantly improved 2 years after surgery. The Sat-2y score was strongly correlated with the SRS-22R self-image (SI)/appearance subdomain (r = 0.64), followed by moderate correlation with subdomains related to standing (r = 0.53), body pain (r = 0.49–0.55), and function (r = 0.41–0.55) at 2 years. Conversely, the correlation between radiographic or demographic parameters with Sat-2y score was weak (r < 0.4). Multivariate analysis to eliminate confounding factors revealed that a worse Oswestry Disability Index (ODI) score for standing (≥ 2 points; OR 4.48) and pain intensity (≥ 2 points; OR 2.07), SRS-22R SI/appearance subdomain (< 3 points; OR 2.70) at 2 years, and a greater sagittal vertical axis (SVA) (> 5 cm; OR 2.68) at 2 years were independent related factors for low satisfaction. According to the other model, a lower improvement in ODI for standing (< 30%; OR 2.68), SRS-22R pain (< 50%; OR 3.25) and SI/appearance (< 50%; OR 2.18) subdomains, and an inadequate restoration of the SVA from baseline (< 2 cm; OR 3.16) were associated with low satisfaction.CONCLUSIONSSelf-image, pain, standing difficulty, and sagittal alignment restoration may be useful goals in improving patient satisfaction with management at 2 years after ASD surgery. Surgeons and other medical providers have to take care of these factors to prevent low satisfaction.
Collusion attacks and fair time-locked deposits for fast-payment transactions in Bitcoin
Authors: Yu Xingjie , Thang Michael Shiwen , Li Yingjiu , Deng Robert Huijie 
Published: May 2019

In Bitcoin network, the distributed storage of multiple copies of the block chain opens up possibilities for double-spending, i.e., a payer issues two separate transactions to two different payees transferring the same coins. While Bitcoin has inherent security mechanism to prevent double-spending attacks, it requires a certain amount of time to detect the double-spending attacks after the transaction has been initiated. Therefore, it is impractical to protect the payees from suffering in double-spending attacks in fast payment scenarios where the time between the exchange of currency and goods or services is shorten to few seconds. Although we cannot prevent double-spending attacks immediately for fast payments, decentralized non-equivocation contracts have been proposed to penalize the malicious payer after the attacks have been detected. The basic idea of these contracts is that the payer locks some coins in a deposit when he initiates a transaction with the payee. If the payer double-spends, a cryptographic primitive called accountable assertions can be used to reveal his Bitcoin credentials for the deposit. Thus, the malicious payer could be penalized by the loss of deposit coins. However, such decentralized non-equivocation contracts are subjected to collusion attacks where the payer colludes with the beneficiary of the depoist and transfers the Bitcoin deposit back to himself when he double-spends, resulting in no penalties. On the other hand, even if the beneficiary behaves honestly, the victim payee cannot get any compensation directly from the deposit in the original design. To prevent such collusion attacks, we design fair time-locked deposits for Bitcoin transactions to defend against double-spending. The fair deposits ensure that the payer will be penalized by the loss of his deposit coins if he double-spends and the victim payee’s loss will be compensated within a locked time period. We start with the protocols of making a deposit for one transaction. In particular, for the transaction with single input and output and the transaction with multiple inputs and outputs, we provide different designs of the deposits. We analyze the performance of deposits made for one transaction and show how the fair deposits work efficiently in Bitcoin. We also provide protocols of making a deposit for multiple transactions, which can reduce the burdens of a honest payer. In the end, we extend the fair deposits to non-equivocation contracts for other distributed systems.
miR-22 Regulates Invasion, Gene Expression and Predicts Overall Survival in Patients with Clear Cell Renal Cell Carcinoma
Authors: Gong Xue , Zhao Hongjuan , Saar Matthias , Peehl Donna M. , Brooks James D. 
Published: May 2019

Background: Clear cell renal cell carcinoma (ccRCC) is molecularly diverse and distinct molecular subtypes show different clinical outcomes. MicroRNAs (miRNAs) are essential components of gene regulatory networks and play a crucial role in progression of many cancer types including ccRCC. Objective: Identify prognostic miRNAs and determine the role of miR-22 in ccRCC. Methods: Hierarchical clustering was done in R using gene expression profiles of over 450 ccRCC cases in The Cancer Genome Atlas (TCGA). Kaplan-Meier analysis was performed to identify prognostic miRNAs in the TCGA dataset. RNA-Seq was performed to identify miR-22 target genes in primary ccRCC cells and Matrigel invasion assay was performed to assess the effects of miR-22 overexpression on cell invasion. Results: Hierarchical clustering analysis using 2,621 prognostic genes previously identified by our group demonstrated that ccRCC patients with longer overall survival expressed lower levels of genes promoting proliferation or immune responses, while better maintaining gene expression associated with cortical differentiation and cell adhesion. Targets of 26 miRNAs were significantly enriched in the 2,621 prognostic genes and these miRNAs were prognostic by themselves. MiR-22 was associated with poor overall survival in the TCGA dataset. Overexpression of miR-22 promoted invasion of primary ccRCC cells in vitro and modulated transcriptional programs implicated in cancer progression including DNA repair, cell proliferation and invasion. Conclusions: Our results suggest that ccRCCs with differential clinical outcomes have distinct transcriptomes for which miRNAs could serve as master regulators. MiR-22, as a master regulator, promotes ccRCC progression at least in part by enhancing cell invasion.
EPIDEMIOLOGIC APPROACH TO QUALITY OF LIFE IN DIABETIC PATIENTS: A SYSTEMATIC REVIEW STUDY
Authors: Feyzi Rezvan , Madmoli Mostafa 
Published: May 2019

Introduction: Diabetes is a common disease with multiple complications that has an increasing trend and affects all aspects of the life of the patients, especially their quality of life. Therefore, considering the chronicity of diabetes and its complications, it causes a lot of material burden on the patient and a decrease in the quality of life in them. Considering that planning to increase the level of health of these patients requires studying on the barriers of their quality of life, this systematic review was conducted with the aim of determining the epidemiological approach to quality of life in diabetic patients.
Materials and Methods: In this systematic review study, in order to achieve the goal of the study and to improve the accuracy of its study and its comprehension, this integrated overview study was conducted based on the Broome method. The purpose of this method was to achieve the purpose of the study and to enhance the study's thoroughness and comprehension. The method is based on three steps in the search of texts, data evaluation and data analysis. In the search phase of the texts, the studies after the retrieval were examined in terms of the criteria for entering the study in four stages. After obtaining the terms of entry into the study, the content of the study is evaluated and at the end the analysis of the data was done.
Results: Several studies have been done on the quality of life of diabetic patients. One study that was conducted in this study was a study that showed a positive and significant correlation between patient's ability with all aspects of their quality of life. Also, there was a significant negative correlation between empowerment and patients age. There was a significant difference in the level of ability of patients according to gender, marital status, type of life, education and income.
Conclusion: According to the results of some studies, it can be said that the level of quality of life in the majority of diabetic elderly people is moderate, and the results of this study show a high need for care in the elderly and emphasize the role of care in improving the health of diabetic elderly. It is also necessary for these patients to be covered in order to receive educational, counseling, care and support services aimed at improving quality of life.
Keywords: Diabetes, quality of life, diabetic patients, epidemiologic approach
MANAGEMENT OF MENOPAUSAL PROBLEMS THROUGH YOGIC PRACTICE
Authors: Naragatti Mr. Siddappa 
Published: May 2019

Menopause involves both physiological and psychological manifestations that result from hormonal changes Basically health is understood as the perfect equilibrium of body, mind, intellect and soul. The person who enjoys lightness of body, slowness of breathing, calmness of mind, control over emotions, action in relaxation and blissful awareness is said to be healthy. Women’s health is bound up with social, cultural and economic factor that influence all aspect of their lives and consequences are born by women themselves. Yoga is a physical and mental practice that involves the body, mind and spirit. The practice, which originated in India, is designed to enhance awareness, create a mind-body-spirit balance, cleanse, heal and strengthen the body, liberate the true self and, as practiced today, improve fitness.
Keywords: Menopausal problem Management Yoga Therapy
La gestión de Marketing de servicios basada en una estrategia de Marketing relacional y su incidencia en el crecimiento empresarial del sector odontológico de la ciudad de Tulcán
Authors: Portilla Bustos Pablo Alejandro 
Published: May 2019

La presente investigación tiene como principal objetivo proponer un esquema sobre la gestión de Marketing, enfocándose en estrategias de Marketing relacional para el consultorio odontológico "Solución Sonrisas" de la ciudad de Tulcán .Se describe la situación actual que atraviesan los consultorios odontológicos de la ciudad de Tulcán, en cuanto a temas de Marketing se refiere, además se justifica el por qué es importante la investigación desarrollada, y se determina los objetivos general y específicos que se plantearon antes de iniciar con la investigación.Mediante fichas de observación se puedo identificar a 36 consultorios odontológicos en la ciudad de Tulcán, utilizando la operacionalización de variables se procedió al diseño de un formulario de la encuesta enfocada hacia los propietarios de los consultorios odontológicos de la ciudad de Tulcán, se continuo con la recolección de esta información y por ultimo al respectivo análisis de la información obtenida.Finalmente incluyo las conclusiones y recomendaciones de los resultados de la investigación realizada.
Análisis de la gestión de recursos humanos por competencias y su incidencia en el Desempeño del personal administrativo de la Universidad Politécnica Estatal del Carchi
Authors: Enríquez Revelo Leidy Soledad 
Published: May 2019

La presente investigación titulada: Análisis de la Gestión de Recursos Humanos por competencias y su incidencia en el Desempeño del Personal Administrativo de la Universidad Politécnica Estatal del Carchi, es un aporte para que el personal administrativo asistencial aumente sus niveles de eficiencia y así pueda contribuir a la consecución de los objetivos institucionales proyectándose a mejorar continuamente. Em primer lugar , se definió las bases teóricas y científicas para determinar la insidencia que existe entre las variables: gestióndel recurso humano y desempeño del personal, a través de la síntesis de la variada bibliografía existente, tanto en las bibliotecas como en internet.
The Effect of Complete Dentures on The Body Mass Index of Elderly Patients
Authors: Asegaff Andi Alifianti Puteri , Adrian Nova 
Published: May 2019

Introduction: As people age, physical changes, such as complete tooth loss, can occur. The therapy for complete tooth loss is to wear complete dentures (CDs). However, this can affect patients’ body mass index (BMI) and overall health, especially in patients who are elderly. BMI is an indicator that is often used to determine a person’s nutritional status.
Objective: The aim of this study was to analyze the effect of wearing a new set of full upper and lower dentures affects the BMI of elderly patients, one month after insertion at Dental Hospital of Dentistry Faculty, Trisakti University.
Method: This was an observational analytic study with a cross-sectional design. The subjects of this study were 31 elderly patients (according to the World Health Organization [WHO] age classification).
Result: Of the 31 elderly patients studied, 7 had an unstable or fluctuating BMI, 12 had a stable BMI from the beginning of CD insertion, 4 showed a consistent increase in BMI, and 2 showed a consistent decrease in BMI but remained in the normal BMI range. Using Spearman’s rank correlation coefficient, the result was shown to be significant (p=0.00), which means there was a strong correlation between CD use and change in BMI (0.76–0.99).
Conclusion: It can be concluded that elderly patients at Dental Hospital of Dentistry Faculty, Trisakti University who are wearing CDs encounter a significant change in BMI. Most of the subjects reached a normal BMI by one month after CD insertion, caused by an increased ability to masticate effectively.
The Effect of Presto Cooker as an Alternative Sterilizer Device for Standard Dental Equipment
Authors: Djais Ariadna Adisattya , Theodorea Citra Fragrantia 
Published: May 2019

Introduction: In the suburb area of Indonesia, autoclaves as a sterilizer could not been used optimally due to inadequate electrical capacity. An alternative sterilizer such as a pressure cooker (presto) have been choosen because it has same principle as an autoclave, but it doesn’t required the electrical supply. Nevertheless, the procedure of presto in dentistry remain unclear.

Objective: To obtain a standard procedure by using presto for dental instrument.

Methods: The effect of presto was observed on aerobic (S. aureus ATCC 25923T), facultative anaerobes (S. mutans ATCC 25175T), anaerobes (P. gingivalis ATCC 33277T) and yeasts (C. albicans ATCC 10231T) which are exposed to the dental mirror. Each dental mirror (triplo) was dipped for 3 minutes on media containing bacteria (106 bacteria/ mL). Furthermore, the dental mirrors were cooked at presto (MAXIM, 7 L, Indonesia) which contained 500 mL of water, for 15, 30 and 45 minutes. Bacterial growth analysis were observed visually and microscopically after Gram staining.

Results: In the S. aureus ATCC 25923T and C. albicans ATCC 10231T groups, up to 30 minutes the color of the media showed cloudy but remained clear when sterilized for 45 minutes. Likewise, these groups showed appereance of bacterial growth for 15-30 minutes but didn’t appear to grow in 45 minutes. While in the S. mutans ATCC 25175T and P. gingivalis ATCC 33277T groups, up to 15 minutes the color of the media showed cloudy but remained clear after being sterilized for 30 minutes. In addition, these groups showed appereance of bacterial growth for 15 minutes but absence in 30-45 minutes.

Conclusion: Presto can be used as one of alternative equipment to sterilize dental instrument, effectively. The optimal killing time of bacteria and yeast was 45 minutes.
Tradition vs. Pop Culture: Attracting Tourists with the Cool Japan Campaign
Authors: Close Natalie 
Published: May 2019

In 2008 the Japanese government set a goal of attracting 20 million foreign tourists by the Olympics in 2020. The country managed to achieve that goal by last year and has since revised their goal to 40 million tourists by 2020. A big part of the drive to increase tourist numbers has been the government led Cool Japan campaign. Attracting foreign tourists remains one of the mainstays of the Cool Japan campaign, as can be seen in the tourist-focused events and advertising witnessed overseas. One of the key aspects of the Cool Japan campaign has been to promote creative cultural industries, in particular businesses associated with anime, manga and gaming. This can be seen in such promotional activities as the closing ceremony for the Rio Olympics and the appointment of anime characters such as Doraemon, Atom Boy and Sailor Moon as ambassadors for Japan.

However, the campaign has been accused of lacking focus as it tries to simultaneously promote aspects of both traditional and modern Japanese culture. This can be seen in the Japan National Tourism Organisation’s promotional campaigns featuring more traditional aspects of Japanese culture such as temples and festivals. In addition, there have been accusations that the Cool Japan campaign has done little to understand what foreign visitors are actually interested in and how best to promote the country. This paper investigates the success of the Cool Japan campaign and looks at the extent to which this fractured focus is actually attracting tourists. The research draws on data collected in Japan with those experiencing Japan as part of their vacation and interviews with tourists. The focus of this paper is on how the Cool Japan campaign influences potential tourists, and how effective the use of anime characters to promote Japan actually is.
Antibiogram and pathogen isolation from vaginal discharge in dairy cows with metritis
Authors: KURT Serdal , SALAR Seçkin , ÖZDAL SALAR Merve 
Published: May 2019

The fertility success of dairy cows is greatly associated with their uterine health status in
the postpartum period. However, the functioning of the uterus in cows is frequently put at risk due to
contamination of the uterine lumen by pathogenic bacteria. The most common
bacterial species causing uterine infections are Escherichia (E) coli, Trueperella (T) pyogenes, Streptococcus
spp, Fusobacterium (F)
necrophorum, Bacteroides and Prevotella.
One of the most prevalent postpartum uterus diseases is defined as metritis. The
objective of this study was to evaluate the bacterial insolation and antibacterial susceptibility resulting from vaginal discharges
in dairy cows with metritis. The study was carried out on 15 multiparous
(between 3 to 6 ages) Holstein dairy cows with metritis. Metritis was
characterized by fever (&gt;39.5°C),
fetid watery red-brown vaginal discharge and systemic signs of diseases in the
first 21 days postpartum. The vaginal swabs for microbiological analysis
and the antimicrobial susceptibility test were taken under aseptic conditions from the cows. As a result, four different types of bacteria were
isolated including E. coli (35.29%), T. pyogenes (29.41%), Streptococcus spp (17.65%) and Staphylococcus (S) aureus (17.65%). Then, 13 antimicrobial agents were used in the
antibiogram test. It was found that the most effective antimicrobial agents
were florfenicol, seftiofur,
oxytetracycline, linkomycin
and penicillin. Also, it was determined that some bacteria species have resistance against antimicrobial
agents. In conclusion, it was concluded that the effects of antimicrobial
agents and metritis agents changed from cow to cow. So, it was thought that
uterine infections causing infertility can be restricted by the isolation of pathogen and the choice of appropriate
antimicrobial agents.
MEDİNE KADISI AHMED RÂŞİD’İN YAYIMLANMAMIŞ ŞİİRLERİ
Authors: KAYAOKAY İlyas 
Published: May 2019

Ahmed Râşid (1844-1934 sonrası),
1901-1903 yılları arasında Medine’de kadılık yapmış bir müellif ve devlet
adamıdır. Farsçadan ve Arapçadan yaptığı tercüme mahiyetindeki dinî-ahlâkî
eserlerle ön plana çıkan Ahmed Râşid hayatı hakkındaki bilgilere, sadece Son Asır Türk Şairleri adlı eserde
rastlanılmaktadır. Bu çalışmada Ahmed Râşid’e ait daha evvel yayımlanmamış dört
manzumenin tanıtımı ve Arap harflerinden Latin alfabesine aktarımı
yapılacaktır.

Bu
manzumelerden ilki, 16 beyitlik bir kıt’a-ı kebiredir. İkincisi, çiçek ve bitki
adlarıyla oluşturulan 35 beyitlik bir bahâriyyedir. Üçüncüsü, mesnevi nazım
şekliyle yazılmış bir leylek ile güvercin arasındaki münazarayı ihtiva eden 26
beyitlik bir manzum fabldır. Son şiir ise 7 beyitlik “it” redifli bir gazeldir.
Ahmed Râşid’in tercüme eserleri gibi bu şiirleri de ağırlıklı olarak hikmetli
sözlerden oluşmaktadır. Bu çalışmayla şairin Pend-nâme-i Lokmân Hekîm Terceme-i Manzûmesi adlı eserinin sonunda
yer alan dört şiiri gün yüzüne çıkarılmıştır.
Meaning and Role of Prototyping in Entropic and Extreme Business Environment in Georgia
Authors: Kldiashvili M. , Paresashvili D. 
Published: May 2019

For a couple of years, the term entropy is gaining popularity as a term to cover the various dimensions of fast and rapidly developing, ‘uncontrollable’ business environment. The more complex and volatile an industry is – the higher is the level of entropy, that means - the harder to predict and therefore more uncertain will be process of new project or product implementation. In simple words, entropy as a measure of uncertainty or randomness, is permanently growing in nowadays business environment.
In common use, A prototype is an early sample, model, or release of a product built to test a concept or process or to act as a thing to be replicated or learned from. Technique of prototyping becomes more efficient if analyzing of prototype occurs together with the potential consumer. Based on received feedback, or analyzing customer experience, lessons learned, company makes decision how to develop the product on the next phase.
In Georgia, use of prototypes started with development of projects related to Information Systems. But later it was successfully applied to product development and Business model development, especially for startups and small entrepreneurs.
Implementing corporate social responsibility as a dynamic capability in recent modern agri-business SMES’ concerns
Authors: Takalandze L. , Mohammad R.N. 
Published: May 2019

The globalizing market economy is not a homogeneous structure. It seeks the emergence of a decentralized regulation of markets coupled with a cosmopolitan and liberal democracy provided by transnational institutions. During this process agricultural sector cannot be hidden and should choose the best practical strategies but in the area of globalized agricultural economy, how should corporate social responsibility (CSR), of agriculture should be managed?
This paper investigates the global economy and corporate social responsibility in the context of agricultural sector.