bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coleoptera genome and transcriptome sequences reveal numerous differences in neuropeptide signaling between species
Authors: Veenstra Jan A. 
Published: June 2019

Background
Insect neuropeptides are interesting for the potential their receptors hold as plausible targets for a novel generation of pesticides. Neuropeptide genes have been identified in a number of different species belonging to a variety of insects. Results suggest significant neuropeptide variation between different orders, but much less is known of neuropeptidome variability within an insect order. I therefore compared the neuropeptidomes of a number of Coleoptera.

Methodology
Publicly available genome sequences, transcriptomes and the original sequence data in the form of short sequence read archives were analyzed for the presence or absence of genes coding neuropeptides as well as some neuropeptide receptors in seventeen beetle species.

Results
Significant differences exist between the Coleoptera analyzed here, while many neuropeptides that were previously characterized from Tribolium castaneum appear very similar in all species, some are not and others are lacking in one or more species. On the other hand, leucokinin, which was presumed to be universally absent from Coleoptera, is still present in non-Polyphaga beetles.

Conclusion
The variability in neuropeptidome composition between species from the same insect order may be as large as the one that exists between species from different orders.
Mid-term Safety and Efficacy of Transcatheter Closure of Ostium Secundum Atrial Septal Defect under Transthoracic Echocardiographic Guidance in Children Weighing Less than 15 Kg
Authors: Arora Harmeet Singh , Bharadwaj Prashant , Chadha Davinder Singh , Malani Susheel , Ghosh Arijit Kumar , Pathak Kamal , Shukla Deepak , Shouche Sachin , Mishra Satish Kumar , Singh Jaswinder , S. Sethi Brijindera 
Published: June 2019

Background: Transcatheter device closure of ostium secundum atrial septal defect is a safe & effective intervention in older children, & is usually done under transesophageal echocardiography guidance. However, the procedure under transthoracic echocardiography guidance, especially in smaller children, is done only at few centers, the data of which is scarce.
Methods: A prospective study was undertaken to assess the mid-term efficacy and outcome of transcatheter device closure of ostium secundum atrial septal defect under transthoracic echocardiographic guidance, in children <15 Kg.
Results: Eighty three children with ostium secundum atrial septal defect were included in the study. Median age of the study population was 3.5 years (1.9-5.6 years), and median weight of 11.6 Kg (7.6 - 14.9 Kg). The primary and secondary procedural success rates were 94% and 96.4% respectively. Post procedure patients were followed up for 12-30 months. Device related major complications were encountered in 4 (4.8%) cases. The total occlusion rates of the defect at 24 hours, 1 month and 3 months post procedure were 94%, 98.8% and 100% respectively.
Conclusion: The transcatheter device closure of ostium secundum atrial septal defect under transthoracic echocardiography guidance, in children <15 Kg, has a high short and mid-term safety and efficacy.
Effect of Nitrogen Fertilization on the Growth and Quality of Tamarind Seedlings Irrigated with Saline Water
Authors: Fatima Reynaldo Teodoro de , Lourdes Gomes da Silva Maria de , Nobrega Jackson Silva , Nobre Reginaldo Gomes , Montenegro Agra Pollyanna Freire , Andrade Figueiredo Francisco Romário , Andrade Ferreira Jean Telvio , Paloma da Silva Leal Márcia , Bezerra Fabiano Simplicio 
Published: June 2019

Aims: The objective of this work was to evaluate the effect of nitrogen fertilization on the production of Tamarindus indica L. seedlings irrigated with saline water.
Study Design: A randomized complete block design was used in a 4 x 4 factorial scheme, whose factors were the electrical conductivity levels of the irrigation water.
Place and Duration of Study: The work was conducted under protected environment conditions (greenhouse) at the Federal University of Campina Grande, Center for Agro-Food Sciences and Technology, Campus of Pombal-PB, Brazil, in the period from January and March 2017.
Methodology: Effects of doses of 0, 100, 200 and 300 mg of nitrogen (N) dm-3 and electrical conductivity levels of the irrigation water (ECw) (0.3, 2.1, 3.7 and 5.2 dS m-1) on growth of Tamarindus indica L. have been studied.
Results: The growth of the seedlings was reduced by the increase of the electrical conductivity of the irrigation water, however, irrigation with ECw water of 2.15 dS m-1, promotes acceptable reductions of 10% in the morphology of the tamarind tree.
Conclusion: The use of nitrogen fertilization with urea did not attenuate the deleterious effects of irrigation water salinity or promoted improvements of the quality of the tamarind seedlings.
ANALISA QUANTITY TAKE-OFF DENGAN MENGGUNAKAN AUTODESK REVIT
Authors: Laorent Danny , Nugraha Paulus , Budiman Januar 
Published: June 2019

Quantity Take-Off merupakan salah satu upaya dari kontraktor dengan melakukan perhitungan volume, yang nantinya akan digunakan sebagai bahan untuk menyusun BQ dalam tender dan nantinya juga dijadikan bahan untuk melakukan procurement. Oleh sebab kontraktor yang dapat melakukan quantity take-off dengan akurat akan mendapatkan beberapa keuntungan seperti pengefisiensian material yang datang karena sesuai dengan aktual. Autodesk Revit merupakan sebuah tools atau aplikasi yang berbasis Building Information Modeling (BIM) yang mampu melakukan quantity take-off. Dalam penelitian ini akan dibahas bagaimana kelebihan dan kelemahan dari Autodek Revit dalam melakukan quantity take-off pada volume beton, bila dibandingkan dengan metode yang selama ini dipakai, yaitu menghitung volume dengan menggunakan gambar dari Autocad dan dengan bantuan Microsoft Excel. Hasil dari penelitian ini menunjukkan bahwa Autodesk Revit dapat melakukan quantity take-off dengan baik dan memiliki beberapa kelebihan seperti, memiliki efisiensi terhadap waktu karena dapat menghitung volume dengan lebih cepat dibandingkan dengan metode sebelumnya, apalagi bila terdapat perubahan desain. Akan tetapi dalam membuat permodelan pada Revit membutuhkan waktu yang cukup lama dan harus teliti agar memperoleh hasil yang akurat.

Quantity Take-Off is one of the efforts of contractors to make calculations volume, which will be used as the object for making Bill of Quantity in the tender and will also be made to make procurement. Therefore contractors who can do quantity take-off accurately will get some advantages such as efficiency material that came as it was in accordance with the actual. Autodesk Revit is a tools or application based on Building Information Modeling (BIM) which is capable of performing quantity take-off. In this research will be discussed how advantages and deficiency of Autodek Revit in quantity take-off to calculate concrete volume, when compared with the method that have been used, it is calculating volume using image from Autocad and help with Microsoft Excel. Result of this research showed that Autodesk Revit can do quantity take-off with good and has a number of advantages such as, have efficiency to the time because they can calculate volume with more rapidly than method before, especially if there is a redesign. But in making modeling in Revit takes a lot of time for a long time to have a careful and is to be accurate results.
Bioactive Nanoparticle‐Embedded Micro/Nanofibrous Dressing with Improved Angiogenesis and Immunoregulation for Facilitating Burn Wound Healing
Authors: Yang Lerong , Wu Yiyang , Yang Bangqi , Huang Hongjun , He Haoqiang , Liu Siyi , Huang Chanting , Qin Zainen , Zheng Li , Shen Chong , Zhao Jinmin 
Published: December 2024

AbstractIn the context of severe burn injuries, the presence of excessive reactive oxygen species (ROS), prolonged microbial infection, and compromised angiogenesis can contribute to the metabolic reprogramming of macrophages, resulting in a dysregulated inflammatory response that hinders the healing process. In this study, cerium oxide nanoparticles (CeNPs) are encapsulated within a silk fibroin‐poly(e‐caprolactone) polymer to create an electrospun PSF/CeNPs nanofiber membrane (PSF/membrane). This membrane is further modified through the addition of an angiopoietin‐1 mimetic peptide, QHREDGS, resulting in the formation of QPSF/CeNPs (QHREDGS modified PSF/CeNPs membrane). In vitro assessments revealed that the QPSF/CeNPs displayed the intended ability to regulate ROS levels, favorable biocompatibility with cells, promoted endothelial cell attachment and growth, exhibited anti‐inflammatory properties through the modulation of macrophage phenotypes from M1 to M2, as well as pro‐angiogenetic and antibacterial effects. In vivo, the membrane dressing demonstrated an acceleration of burn wound healing, promotion of angiogenesis, downregulation of inflammatory factors, and enhancement of collagen deposition. This bioactive membrane dressing shows potential as a clinical therapy for promoting the regeneration of both acute and chronically damaged skin tissue.
Nanoformula Design for Inducing Non‐Apoptotic Cell Death Regulation: A Powerful Booster for Cancer Immunotherapy
Authors: Hu Yi , Yu Qing , Li Xia , Wang Juan , Guo Lanping , Huang Luqi , Gao Wenyuan 
Published: December 2024

AbstractCancer treatment has witnessed revolutionary advancements marked by the emergence of immunotherapy, specifically immune checkpoint blockade (ICB). However, the inherent low immunogenicity of tumor cells and the intricate immunosuppressive network within the tumor microenvironment (TME) pose significant challenges to the further development of immunotherapy. Nanotechnology has ushered in unprecedented opportunities and vast prospects for tumor immunotherapy. Nevertheless, traditional nano‐formulations often rely on inducing apoptosis to kill cancer cells, which encounters the issue of immune silencing, hindering effective tumor immune activation.The non‐apoptotic modes of regulated cell death (RCD), including pyroptosis, ferroptosis, autophagy, necroptosis, and cuproptosis, have gradually garnered attention. These non‐apoptotic cell death pathways can induce effective immunogenic cell death (ICD), enhancing cancer immunotherapy. This review comprehensively explores advanced nano‐formulation design strategies and their applications in enhancing cancer immunotherapy by promoting non‐apoptotic RCD in recent years. It also discusses the potential advantages of these strategies in inducing tumor‐specific non‐apoptotic RCD. By deeply understanding the significance of non‐apoptotic RCD in synergistic cancer immunotherapy, this article provides valuable insights for developing more advanced nano‐delivery systems that can robustly induce highly immunogenic non‐apoptotic modes, offering novel research and development avenues to address the clinical challenges encountered by immunotherapy represented by ICB.
Wearable Single‐Electrode Capacitive Sensor with Large Penetration Depth for Intelligent Deep Tissue and Hemorrhage Monitoring
Authors: Cheng Yu‐Jen , Kim Shawn , White Nathan , Wang Xu , Ringgold Kristyn , Neidig Lauren , Kwon Younghoon , Chung Jae‐Hyun 
Published: December 2024

AbstractMonitoring deep tissue biometrics is crucial in various clinical settings, including internal hemorrhage. Although optical and impedance tomography techniques offer real‐time monitoring with minimal medical infrastructure, they still face challenges in accurately assessing deeper tissues in wearable formats. This study introduces a novel single‐electrode capacitive sensor designed to measure deep tissue capacitance changes caused by variations in dielectric constant and pressure. The sensor features a carbon nanotube‐paper composite (CPC) electrode integrated with a multi‐walled carbon nanotube (MWCNT)‐embedded foam. The CPC electrode, with its large surface area and high‐aspect‐ratio fibers, generates a high electric field for deeper tissue penetration, improving deep tissue monitoring performance. Penetration depth is characterized using surrogate tissue, heart, and lung models. Additionally, the integration of pressure‐sensitive MWCNT foam significantly enhances the sensitivity, enabling precise detection of regional blood volume and tissue displacement. The novel sensing mechanism is applied to detect internal hemorrhage in a porcine model. By employing a machine learning algorithm, the sensor accurately estimates the severity of internal hemorrhage, offering a noninvasive alternative to catheter‐based systems. This advancement lays the foundation for a real‐time wearable system that monitors deep tissue health metrics, such as blood volume, blood pressure, as well as heart and lung functions.
Metal‐Organic Frameworks: A Solution for Greener Polymeric Materials with Low Fire Hazards
Authors: Sun Xiuhong , Miao Weijia , Pan Ye‐Tang , Song Pingan , Gaan Sabyasachi , Ibarra Laia Haurie , Yang Rongjie 
Published: December 2024

AbstractThe non‐degradability of polymeric materials and the flammability of their products have resulted in significant environmental pollution. Metal‐organic frameworks (MOFs) serve as innovative flame retardants, featuring a high specific surface area, ample pore volume, and customizable structure. By leveraging the structural adjustability of MOFs, biological modifiers containing flame retardant elements can be integrated into MOFs, thereby ensuring flame retardation while imparting biodegradable properties. Moreover, the issue of material pollution can be effectively addressed by utilizing MOFs as flame retardants within renewable polymer matrices. Recently, an increasing number of researchers have concentrated on developing green flame‐retardant polymer materials using MOFs. However, as far as is known, no comprehensive review on green polymers with minimal fire risk produced using MOFs currently exists. Consequently, this study reviews the recent advancements in the development of green flame‐retardant polymer materials utilizing MOFs, covering the preparation and utilization of bio‐based and recyclable MOFs. Additionally, a flame‐retardant renewable matrix based on MOFs is also synthesized. Furthermore, this review anticipates discussing the benefits and drawbacks associated with using MOFs to manufacture green flame‐retardant polymer products. This work aims to assist researchers in rapidly comprehending the most recent advancements in this field and guiding efficient design.
Stable Biotherapeutic Penetration Screening in Critically Small Colorectal Metastatic Cancer Biopsies Allows for Oncolytic Virus‐Delivered Chemotherapeutic Response Assessment through 3D Bioprinted Organoid Expansion
Authors: McGuckin Colin , Forraz Nico , Milet Clément , Lacroix Mathieu , Sbirkov Yordan , Sarafian Victoria , Ebel Caroline , Spindler Anita , Koerper Véronique , Quéméneur Eric , Balloul Jean‐Marc , Erbs Philippe 
Published: December 2024

AbstractOncolytic viral‐delivered chemotherapeutics have exciting potential for metastatic cancer therapies, including colorectal cancer, but require advanced screening systems for better patient prediction. We optimized primary metastatic colorectal tumor processing and 3D (3‐dimensional) bioprinted tumors to prove efficacy as long‐term screening systems. Normally, this time period would use animals, but we show it is possible to gain useful data in vitro before preclinical stages, to reduce animal modeling and give better clinical trial predictions. Liver tumors were collected from 12 colorectal cancer patients, evaluated for expansion, 3D bioprinted, and tested for ability to create long‐term organoid models with screening of oncolytic viral‐loaded FCU1 enzyme conversion of 5‐fluorocytosine (5‐FC) into the highly toxic 5‐fluorouracil (5‐FU). Donated tumor size was the limiting factor. 75% of patients could be used for screening of viral delivery. Response between patients was overall positive, with good secondary tumor development, outer active cellular content and inner necrotic core. Oncolytic challenge shows good screening potential and cellular targeting, demonstrating an added bystander effect, optimizing the low‐dose. Stable long‐term metastatic organoid models were made, lasting many months, with potential for retesting rather than one‐off analysis. Oncolytic virus‐delivered chemotherapy is promising and warrants further investigation for metastatic colorectal cancers.
Comprehensive Review on Slot‐Die‐Based Perovskite Photovoltaics: Mechanisms, Materials, Methods, and Marketability
Authors: Shin Thant Ko Ko , Seriwattanachai Chaowaphat , Jittham Thantham , Thamangraksat Naruedej , Sakata Patawee , Kanjanaboos Pongsakorn 
Published: December 2024

AbstractAs the world edges closer to perovskite solar cell (PSC) commercialization, state‐of‐the‐art materials and processes become publicized to a much lesser degree. From current insights into perovskite industry standards, slot‐die coating is the number one method for fabricating the perovskite layer. Other significant layers can be done using varying techniques. Hence, in this review article, all 115 existing slot‐die‐based PSC publications to date together with related literature are crystallized to set stages for future scalable perovskite research. Through investigation of the effects of materials, processes, and structures on performance, stability, and cost of slot‐die coating is presented. In the end, power output x operating lifetime per cost is the most influential factor for market consideration. The roll‐to‐roll compatibility of the slot‐die coating together with low‐cost materials and lean processes present a cost‐effective strategy for successful commercialization.
The Elastic Covalent Polycysteine Crosslinked Binary Hollow FeS2 Nanospheres for Highly Reversible Sodium Storage
Authors: Li Yue , Zhao Ruiyang , Liu Fusheng , Qin Guohui , He Xiangming 
Published: December 2024

AbstractThe high irreversibility to FeS2‐based anode thwarts its applicability in sodium ion batteries (SIBs), originally stem from the sluggish Na+ insertion/extraction kinetics, confined by the high desolvation barrier, the thick electric double layer (EDL) and the long transport routine inside FeS2. Herein, the covalent polypeptide oligomers (Pcy) based on cysteine (Cy) with β‐sheet configuration grafted binary hollow carbon coupled FeS2@Fe2O3 heterostructure, i.e., FeS2/Fe2O3@C@Pcy, are designed to achieve low desolvation barrier, the contracted EDL via weakened coulombic interaction stems from the zwitterionic feature and enhanced Na+ transport capacity inside FeS2. The semi‐interpenetrating oligomers possessing a weak coordination environment, massively accelerate the desolvation kinetics, additionally, the orderly and dense vertical occupation within the inner Helmholtz plane (IHP) also enormously reduces thickness of EDL. The binary hollow structure complex possessing typical ion looping routine considerably expedites the Na+ transport kinetics inside anode. Both experimental and theoretical trials demonstrate such FeS2 composite manifests a high reversibility in Na+ storage in virtue of exceptional structure stability, rapid ion transport kinetics, and swift reaction kinetics.
SURF1 Deficiency: Expanding on Disease Phenotype and Assessing Disease Burden by Describing Clinical and Biochemical Phenotype
Authors: Kayani Saima , Daescu Victor , Dahshi Hamza , Messahel Souad , Woleban Kasey , Minassian Berge A. , Ling Qinglan , Gray Steven J. 
Published: December 2024

ABSTRACTLeigh syndrome, a severe neurological disorder is commonly caused by homozygous or bi‐allelic pathogenic variants in the SURF1 gene. SURF1 deficiency leads to dysfunction of Cytochrome C Oxidase (COX) activity, which is crucial for mitochondrial oxidative phosphorylation. Understanding COX activity's correlation with disease severity is essential for developing SURF1 Leigh Syndrome biomarkers. This study assesses the disease burden in SURF1 Leigh Syndrome and evaluates COX activity as a treatment biomarker. We reviewed records and questionnaires from 17 individuals, classifying them into phenotypic and genotypic groups. We compared COX activity assays in patient fibroblasts to age‐matched controls, clinical data, and neuroimaging findings. Patient COX activity was at most 50% of controls, averaging 32% (p < 0.001). Common clinical features included brainstem abnormalities (93.3%), motor regression (92.3%), bi‐allelic heterozygous SURF1 variants (88.2%), and delayed growth/development (35.7%). Homozygous and heterozygous nonsense/frameshift variants showed more severe phenotypes (p = 0.008) and more MRI abnormalities (p = 0.005). Significant COX activity reduction is linked to SURF1 Leigh Syndrome, with genotype influencing disease severity. Clinical and neuroimaging correlations show potential for prognostic indicators. This study lays the groundwork for future research and clinical application of COX activity as a SURF1 Leigh Syndrome biomarker.
Alkylated Quinolines through Benzylic sp3 C−H Functionalization: Sequential Synthesis and Photophysical Studies
Authors: Suresh Sundararajan , Keerthana Pari , Nawaz Khan Fazlurrahman 
Published: December 2024

AbstractAn efficient method has been developed for the green synthesis of alkylated quinolines via Cu‐TEMPO catalyzed dehydrogenation, and DEP/DES‐assisted benzylic C−H functionalization followed by cross Rauhut‐Currier type reaction. The reaction mechanism is elucidated through control experiments and 1H NMR reaction monitoring. This transformation offers several advantages, including moderate to good yields of the desired products, mild reaction conditions, use of a cost‐effective metal catalyst, good functional group tolerance, and applicability to gram‐scale synthesis. Additionally, the synthetic utility and the photophysical properties of the synthesized alkylated quinoline derivatives were investigated.
Diphenylperylene Isomers as Novel Emissive Organic Semiconductors
Authors: Chen Liangliang , Wang Ying , Liu Zitong 
Published: December 2024

AbstractEmissive organic semiconductors are crucial for integrated optoelectronic devices, yet only a limited number of materials exhibit high mobility and high photoluminescence quantum yield because of the contradictory requirements for molecular stacking. In this study, two diphenylperylene isomers, 39P‐Ph and 310P‐Ph, were successfully synthesized through a one‐step process by varying the positions of the substituent phenyl groups on the perylene core. Both compounds were comprehensively characterized and demonstrated excellent hole transport capabilities and moderate photoluminescence quantum yield (PLQY), along with long‐wavelength emission, establishing them as effective emissive organic semiconductors. 39P‐Ph emits orange‐yellow fluorescence in crystalline powder with an absolute PLQY of 15.4 % and 310P‐Ph shows orange‐red emission with an emissive wavelength of up to 612 nm in 17.5 % PLQY. Moreover, the carrier mobilities of 39P‐Ph and 310P‐Ph are up to 3.05 cm2 V−1 s−1 and 1.36 cm2 V−1 s−1, respectively, based on the single‐crystal devices. These results reveal that 39P‐Ph and 310P‐Ph are promising candidates as emissive semiconductors, offering a balance between efficient charge transport and light emission for integrated optoelectronic applications.