bluuebunny/crossref_metadata_2025_split huggingface dataset:
XH3 (X=P or N) Adsorption on Pristine, Pt-Doped and Vacancy-Defective (8,8) Boron Nitride Nanotubes: DFT Calculations
Authors: Rakhshi Mahdi , Mohsennia Mohsen , Rasa Hossein 
Published: May 2018

Abstract
The adsorption energies (E
ad), interaction distances, changes of geometric and electronic structures of XH3 (X=P or N) gas molecule adsorption on pristine, platinum (Pt) doped and vacancy-defected single-walled (8,8) boron nitride nanotubes (BNNTs) have been calculated using the density functional theory (DFT). The effect of the Pt doping on B and N sites (PtB,N-doped) and the B and N vacancy defects (VB,N-defected BNNT) on the sensing behavior of pristine (8,8) BNNTs toward PH3 and NH3 gases have been examined. According to the obtained results, PH3 and NH3 molecules were more likely to be absorbed on the PtB,N-doped and VN-defected BNNT with relatively higher E
ad compared with the pristine and VB-defected BNNTs. Therefore the order of the obtained E
ad were PtB-doped BNNT/NH3>PtB-doped BNNT/PH3>PtN-doped BNNT/NH3>PtN-doped BNNT/PH3 for the PtB,N-doped BNNTs, and VN-defected BNNT/NH3>VN-defected BNNT/PH3>VB-defected BNNT/NH3>VB-defected BNNT/PH3 for the VB
,
N-defected BNNTs systems. The partial density of states (PDOS) of the adsorption systems indicated the strong interaction between the adsorbed PH3 and NH3 molecules and the substrates, i.e. PtB,N-doped BNNT and VN-defected BNNT. Therefore, it can concluded that the PtB,N-doped and VN-defected BNNTs have potential applicability in the gas-sensing detection of PH3 and NH3 with good sensitivity.
Starting at the Ground Up: Range of Motion Requirements and Assessment Procedures for Weightlifting Movements
Authors: Bousquet Brett A. , Olson Thomas 
Published: May 2018

ABSTRACT
NOT ALL WHO PERFORM OR COACH WEIGHTLIFTING MOVEMENTS (WMs) SUCH AS THE CLEAN AND JERK AND SNATCH ARE AWARE OF THE MOBILITY REQUIREMENTS NEEDED TO PERFORM THE MOVEMENTS CORRECTLY. CURRENTLY, NO SUCCINCT ASSESSMENT EXISTS DESIGNED TO EVALUATE ALL THE RANGE OF MOTION REQUIREMENTS NEEDED TO PERFORM THESE WMs. THE PURPOSE OF THIS ARTICLE IS TO DISCUSS THE JOINT AND BIOMECHANICAL FORCES EXPERIENCED DURING WM AND TO PROPOSE ASSESSMENT MEASURES THAT ATTEMPT TO OBJECTIVELY PAIR THE MOTION REQUIREMENTS OF WMs WITH RESEARCH-SUPPORTED VALUES AND TESTS TO DETERMINE WHETHER AN ATHLETE HAS THE REQUISITE MOTION AVAILABLE TO PERFORM A TECHNIQUE BEFORE ADDING EXTERNAL LOAD. FOR A VIDEO ABSTRACT OF THIS ARTICLE, SEE SUPPLEMENTAL DIGITAL CONTENT 1 (SEE VIDEO, HTTP://LINKS.LWW.COM/SCJ/A242).
Bayesian Networks Predict Neuronal Transdifferentiation
Authors: Ainsworth Richard I , Ai Rizi , Ding Bo , Li Nan , Zhang Kai , Wang Wei 
Published: May 2018

Abstract
We employ the language of Bayesian networks to systematically construct gene-regulation topologies from deep-sequencing single-nucleus RNA-Seq data for human neurons. From the perspective of the cell-state potential landscape, we identify attractors that correspond closely to different neuron subtypes. Attractors are also recovered for cell states from an independent data set confirming our models accurate description of global genetic regulations across differing cell types of the neocortex (not included in the training data). Our model recovers experimentally confirmed genetic regulations and community analysis reveals genetic associations in common pathways. Via a comprehensive scan of all theoretical three-gene perturbations of gene knockout and overexpression, we discover novel neuronal trans-differrentiation recipes (including perturbations of SATB2, GAD1, POU6F2 and ADARB2) for excitatory projection neuron and inhibitory interneuron subtypes.
Heritable Epigenomic Changes to the Maize Methylome Resulting from Tissue Culture
Authors: Han Zhaoxue , Crisp Peter A , Stelpflug Scott , Kaeppler Shawn M , Li Qing , Springer Nathan M 
Published: May 2018

Abstract
DNA methylation can contribute to the maintenance of genome integrity and regulation of gene expression. In most situations, DNA methylation patterns are inherited quite stably. However, changes in DNA methylation can occur at some loci as a result of tissue culture resulting in somaclonal variation. To investigate heritable epigenetic changes as a consequence of tissue culture, a sequence-capture bisulfite sequencing approach was implemented to monitor context-specific DNA methylation patterns in ∼15 Mb of the maize genome for a population of plants that had been regenerated from tissue culture. Plants that have been regenerated from tissue culture exhibit gains and losses of DNA methylation at a subset of genomic regions. There was evidence for a high rate of homozygous changes to DNA methylation levels that occur consistently in multiple independent tissue culture lines, suggesting that some loci are either targeted or hotspots for epigenetic variation. The consistent changes inherited following tissue culture include both gains and losses of DNA methylation and can affect CG, CHG, or both contexts within a region. Only a subset of the tissue culture changes observed in callus plants are observed in the primary regenerants, but the majority of DNA methylation changes present in primary regenerants are passed onto offspring. This study provides insights into the susceptibility of some loci and potential mechanisms that could contribute to altered DNA methylation and epigenetic state that occur during tissue culture in plant species.
Human-Mediated Introgression of Haplotypes in a Modern Dairy Cattle Breed
Authors: Zhang Qianqian , Calus Mario P L , Bosse Mirte , Sahana Goutam , Lund Mogens Sandø , Guldbrandtsen Bernt 
Published: May 2018

AbstractDomestic animals provide a robust model system to understand complex evolutionary processes and their genomic consequences. Zhang et al. use full re-sequenced genomes of modern dairy cattle to identify haplotypes in the genomes of an admixed....Domestic animals can serve as model systems of adaptive introgression and their genomic signatures. In part, their usefulness as model systems is due to their well-known histories. Different breeding strategies such as introgression and artificial selection have generated numerous desirable phenotypes and superior performance in domestic animals. The modern Danish Red Dairy Cattle is studied as an example of an introgressed population. It originates from crossing the traditional Danish Red Dairy Cattle with the Holstein and Brown Swiss breeds, both known for high milk production. This crossing happened, among other things due to changes in the production system, to raise milk production and overall performance. The genomes of modern Danish Red Dairy Cattle are heavily influenced by regions introgressed from the Holstein and Brown Swiss breeds and under subsequent selection in the admixed population. The introgressed proportion of the genome was found to be highly variable across the genome. Haplotypes introgressed from Holstein and Brown Swiss contained or overlapped known genes affecting milk production, as well as protein and fat content (CD14, ZNF215, BCL2L12, and THRSP for Holstein origin and ITPR2, BCAT1, LAP3, and MED28 for Brown Swiss origin). Genomic regions with high introgression signals also contained genes and enriched QTL associated with calving traits, body confirmation, feed efficiency, carcass, and fertility traits. These introgressed signals with relative identity-by-descent scores larger than the median showing Holstein or Brown Swiss introgression are mostly significantly correlated with the corresponding test statistics from signatures of selection analyses in modern Danish Red Dairy Cattle. Meanwhile, the putative significant introgressed signals have a significant dependency with the putative significant signals from signatures of selection analyses. Artificial selection has played an important role in the genomic footprints of introgression in the genome of modern Danish Red Dairy Cattle. Our study on a modern cattle breed contributes to an understanding of genomic consequences of selective introgression by demonstrating the extent to which adaptive effects contribute to shape the specific genomic consequences of introgression.
Strategy to Improve Firm Performance Through Operational Efficiency Commitment to Environmental Friendliness: Evidence From Indonesia
Authors: Utomo Mohamad Nur , Wahyudi Sugen , Muharam Harjum , Taolin Maximus Leonardo 
Published: May 2018

The objective of this study is to examine the effect of controlling shareholders’ monitoring on firm performance through the implementation of operational efficiency commitment to environmental friendliness. Non-financial firms listed on the Indonesia Stock Exchange and joining the Environmental Performance Assessment Program (PROPER) are determined as the sample. Results indicate that controlling shareholders have a positive impact on operational efficiency commitment to environmental friendliness and also on firm performance. In addition, other key findings indicate that the controlling shareholders can improve firm performance through the implementation of operational efficiency commitment to environmental friendliness. The results of this study support the position of the agency theory, the stakeholder theory, and the legitimacy theory. Operational efficiency commitment to environmental friendliness is then suggested to be a meaningful strategy for the firms to obtain sustainable performance.
Motives to use Facebook and problematic Facebook use in adolescents
Authors: Marino Claudia , Mazzieri Elena , Caselli Gabriele , Vieno Alessio , Spada Marcantonio M. 
Published: May 2018

Background and aims
There is a growing body of evidence suggesting that problematic Facebook use (PFU) is an emerging problem, particularly among adolescents. Although a number of motivations explaining why people engage in frequent Facebook use have been identified, less is known about the specific psychological needs underlying PFU. The aim of this study is to test a model designed to assess the unique contribution of psychological motives for using Facebook to the different PFU dimensions in a sample of adolescents.

Methods
A total of 864 Italian adolescents participated in the study. Multivariate multiple regression was run to test whether the four motives were differently associated with problematic dimensions.

Results
The results showed that the two motives with negative valence (coping and conformity) were significantly linked to the five dimensions of PFU, whereas the two motives with positive valence (enhancement and social) appeared to be weaker predictors for three out of these five dimensions.

Discussion and conclusion
In conclusion, psychological motives for using Facebook appeared to significantly contribute to explaining PFU among adolescents, and should be considered by researchers and educational practitioners.
Clinical application of calcium hydroxide in dental pathology and endodontics
Authors: Lačević Amela , Vranić Edina , Zulić Irfan 
Published: May 2018

Calcium hydroxide has a hard tissue inducing effect. It is a powder, that can be mixed with a physiological saline to a paste. The paste is highly alkaline with a pH 12.5 and its application to the pulp results in necrosis of the part of coronal pulp tissue shows no or only a milled inflammatory reaction. Analyzing the pH and the concentration of calcium ions in the periapical area, it is obvious that at least 2 weeks are necessary for calcium hydroxide bactericide activity. Calcium hydroxide retains its anti-bacterial properties for about two months when placed under a restoration, after which it degrades to calcium oxide and other less effective calcium salts. All calcium hydroxide preparations have a limited shelf life as they eventually turn into calciumoxide. Calcium hydroxide can be used as linings, for indirect and direct pulp cupping, root dressing, root canal sealant, apical closure. The vehicles play a supportive role, giving pastes chemical characteristics such as dissociation and diffusion as well as favoring the correct filling of the root canal which are decisive factors for antimicrobial potential and tissue healing. The mechanism of action of calcium hydroxide on tissues, inducing the deposition of mineralized tissue, is an extremely important aspect for the indication of calcium hydroxide, because it demonstrates biological compatibility of calcium hydroxide.
QSAR and QSPR study of derivatives 4-arylaminocoumarin
Authors: Završnik Davorka , Muratović Samija , Špirtović Selma 
Published: May 2018

Coumarin and its derivatives are reactive compounds, suitable for many syntheses. They are used as anticoagulants, antibacterial, animistic compounds. The interest in coumarins has increased because it was found that they reduce the HIV virus activity. The synthesis of 4-arylaminocoumarin derivatives from 4-hydroxycoumarin, has been carried out, and their antimycotic effects were tested. In the QSAR (quantitative structure-activity relationship) QSPR (quantitativestructure-property-activity relationship) study we have used physicochemical properties and topological indices (Balaban index J(G), Wiener index W(G), information-theoretical index I(G), and valence connectivity index (G), to predict bioactivity of the newly synthesized coumarin compounds. By using methods of molecular modelling, the relationships between structure, properties and activity of coumarin compounds have been investigated. The best QSPR models were obtained using valence connectivity index or combination indices. According Rekker's method the best correlation of calculated values log P, has been obtained with the model based on the inhibition zone (I) 4-arylaminocoumarin derivatives expressed in mm. The results obtained in this study enable further synthesis of new coumarin derivatives and predict their biological activity and properties.
Type IV collagen immunoreactivity of basement membrane in inflammatory-regenerative and dysplastic lesions of the flat colonic mucosa
Authors: Radović Svjetlana , Selak Ivan , Babić Mirsad , Knežević Željka , Vukobrat-Bijedić Zora 
Published: May 2018

The aim of this research is to establish by immunohistochemistry if there is a change in the expression of collagen type IV, as a substitute of basement membrane, in development of epithelial dysplasia in chronically inflamed colon mucosa.Methods. Biopsy specimens from 270 patients were examined: 74 were classified as inflammatory-regenerative and 196 as dysplastic lesions. There were 108 cases of mild dysplasia, 58 cases of moderate and 30 cases severe dysplasia, respectively. Visualisation of collagen IV and its way of expression within basement membrane of glandular crypts was performed by immunohistochemistry and then compared with findings in normal colon mucosa and colon adenocarcinoma tissue.Results. Changes in the expression of collagen IV comprised of its focal irregularities, diffuse thinning and/or thickening, focal interruptions or its complete absence. Significant changes in the expression of collagen IV in relation to normal mucosa already occur in inflammatory-regenerative mucosa. In mild dysplasia, these changes are more intensive in relation to those in inflammatory altered mucosa as well as at severe dysplasia in relation to moderate dysplasia. Changes in the expression of collagen IV in severe dysplasia are significantly more serious than in moderate dysplasia but are identical to those in colon adenocarcinoma tissue.Conclusion. These findings suggest that change in the expression of collagen IV is in correlation to a degree of epithelial dysplasia that developed in flat chronically inflamed colon mucosa.
Pathohistological changes in diffuse coronary atherosclerosis and chronic infection caused by Chlamydia pneumonia.
Authors: Legan Mateja , Vraspir-Porenta Olga , Kese Darja , Zorc-Plesković Ruda , Zorc Marjeta 
Published: May 2018

BACKGROUND AND PURPOSE: To investigate the histopathologic characteristics of atherosclerotic lessions in diffuse coronary artery disease and to evaluate the possible inflammatory role of chronic infection with Chlamydia pneumoniae (CP).MATERIALS AND METHODS: For 10 patients (males, mean age 61 years) who were surgically treated for grave diffuse coronary artery disease, histomorphological analyses of endarterectomized segments of the coronary arteries were performed. Serological analyses for the detection of CP antibodies in peripheral blood were done, preoperatively.RESULTS AND CONCLUSIONS: Diffuse and concentric atherosclerotic changes from VI to VIII stage according to the Stary classification were found. Immunohistochemical methods revealed infiltrates of T-lymphocytes (80% of cases), B-lymphocytes (40% of cases) and macrophages (80%). Using the nuclear marker for proliferation activity MIB-1, single MIB-1 positive cells were found in 40% of cases. Features of arteriologenesis and vasculitis of newly formed arterioles (as well as thickening of the wall of newly formed arterioles) were found in the vessel wall of 8 patients, 7 of them had chronic infection with CP (preoperative micro-immunofluorescent test results: 1:32<IgG ≥1:512 and IgA≥32), one had passed CP infection (1:32 ≤IgG<1:512, IgA negative). These features were absent in 2 patients, both recovered from CP infection and had not the chronic CP infection at the time of surgery. DNA of Chlamydia pneumoniae was detected using the polymerase chain reaction (PCR) method in the vessel wall of 3 patients who were chosen randomly for this method. This study suggests an inflammatory and proatherogenic role of CP in a high grade atherosclerotic coronary artery wall in diffuse coronary artery disease.
Protective effect of neonatal BCG vaccines against tuberculous meningitis
Authors: Puvacić Sandra , Dizdarević Jadranka , Santić Z. , Mulaomerović M. 
Published: May 2018

Neonatal BCG vaccination reduces the risk of tuberculosis and provides protection higher than 80% against the development of meningeal and miliary tuberculosis in newborns. Tuberculosis meningitis remains a major problem and also an important cause of death in some countries. In countries with high and moderate incidence of tuberculosis, prevention from the most severe complications of tuberculosis can be achieved only with a high coverage of the universal BCG neonatal immunization, being higher than 98% in the cohort of newborns. The decrease in BCG immunization coverage within immunization program during the year 2003 in Bosnia and Herzegovina influenced the increase in tuberculous meningitis. During 2002, when coverage with BCG vaccination in cohort of newborns was 90%, the incidence rate of tuberculous meningitis was 19. 04%oo. With the 68% decrease in BCG immunization coverage in the cohort of newborns in Bosnia and Herzegovina during the year 2003, the incidence of tuberculous meningitis raised to 33 33%oo. It has been proven that the 22% decrease of the neonatal BCGimmunization coverage in the cohort of newborns /vaccination program of children/ caused 175 times higher number of the tuberculous meningitis cases. Newborns affected by the tuberculous meningitis were not BCG vaccinated. BCG vaccineprovided effective protection against tuberculous meningitis, as well against the death of newborns caused by tuberculosis.
Cytogenetics findings at Turner Syndrome and their correlation with clinical findings
Authors: Ćatović Amra , Kendić Sulejman 
Published: May 2018

Turner Syndrome is a genetic condition in females that results from an abnormal chromosome. One of the X chromosomes is missing or misshapen in the most cells of the body. Three classics clinical symptoms of the syndrome are: incomplete sexual maturation, short stature and pterygium colli. Turner Syndrome is diagnosed by karyotyping. In the retrospective study for a twelve years period (1991-2002) correlation between clinical and cytogenetics findings was established in our Center among 47 examinees from all parts of Federation of Bosnia and Herzegovina, who had suspect clinical diagnosis of Turner Syndrome. The syndrome was demonstrated by cytogeneticsexaminations in 30(63,8%) examinees and excluded in 17 (36,2%) examinees. The most frequent karyotype is monosomy of X chromosome (45,X) found at 63,3%, than isochromosome of Xq (46,XisoXq) found at 16,7%, mosaic form (46,XX/45,X) and deletion of Xp (46,XdelXp) both at 6,7%, than deletion of Xq (46,XdelXq) and ring of Xp (46,XX/46,XringXp) both at 3,3%. Our results suggest that promptly and exactly diagnosis of Turner syndrome is very important due to introducing growth hormone therapy and estrogen therapy at a very young age.
Nitric Oxide in Gentamicin-induced Acute Tubular Necrosis in Rats
Authors: Nakaš-Ićindić Emina , Avdagić Nesina , Mijanović Mirjana , Prašović Senad , Začiragić Asija , Začiragić Asija , Tahirović Gordan 
Published: May 2018

Gentamicin is still widely used in clinical practice in spite of its renal toxicity. The role of nitric oxide (NO) in that process is not completely elucidated. The aim of this study was to investigate the relationship between plasma level of NO and the histopathological changes of kidney in acute tubular necrosis (ATN) induced by gentamicin in rats. Study was carried out in Albino-Wistar rats, both sexes (n=16), average body weight 200-250 g. divided in two equal groups: control and gentamicin group. The control group was injected with 0.9% NaCl i.p. and gentamicin group was injected with gentamicin in the dose of 80 mg/kg/day i.p. in a period of 5 consecutive days. NO plasma level was determined by the production of nitrates and nitrites using classical colorimetrical Griess reaction. Kidney specimens were stained with hematoxylin-eosin (H-E) and Periodic acid-Schiff (PAS) stain. Semiquantitative histological analysis was used for the evaluation of the level of kidney damage. Both, the plasma NO level and the level of kidney damage were statistically higher in rats with gentamicin-induced ATN in comparison to the control group. In spite of that the correlation between plasma NO level and the level of kidney damage was not found. The rise of plasma level NO in gentamicin induced ATN in rats could possibly indicate on the role of NO in renal damage caused by gentamicin.
Correlation of the HER-2 protein expression and other clinicopathological features of ductal infiltrative breast cancer
Authors: Radović Svjetlana , Babić Mirsad , Dorić Mirsad , Balta Edina , Kapetanović Erol , Šečić Senad 
Published: May 2018

The aim of the study was to investigate the relationship between the expression of the HER-2 membrane protein and other clinical-pathological parameters such as: histological size of the tumor, degree of the tumor's differentiation, presence of vascular invasion and presence of metastases in regional lymph nodes, in cases of ductal infiltrative breast cancer. We have investigated 56 cases of ductalinfiltrative breast cancer. In all patients a mastectomy with a dissection of axillary lymph nodes has been performed. All tissue samples, taken by biopsy, were embedded in the paraffin, stained by hematoxylin-eosin technique and screened, and evaluation was performed by using a semiquantitative method of the immunohistochemical expression of the HER-2 protein. A decrease of the protein HER-2 expression was noticed in cases of an increase of the tumor's diameter above 50 mm. Increased expression of the HER-2 protein was noticed in cases of moderate (grade II) and poor (grade III) differentiation of carcinoma, as well as in cases where there was no metastases in the regional lymph nodes. No relationship has been observed between the expression of HER-2 and occurrence of vascular invasion. In cases of ductalinfiltrative breast cancer the expression of HER-2 protein is in correlation with the size and degree of tumor's differentiation, as well as with the presence of metastases in regional lymph nodes.