bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sichtbares Licht ermöglicht Ruthenium‐katalysierte meta‐C‐H‐Alkylierung bei Raumtemperatur
Authors: Gandeepan Parthasarathy , Koeller Julian , Korvorapun Korkit , Mohr Jens , Ackermann Lutz 
Published: May 2019

AbstractDie durch sichtbares Licht induzierte Rutheniumkatalyse ermöglicht meta‐selektive C‐H‐Alkylierungen mit hoher Regioselektivität unter milden Bedingungen bei Raumtemperatur. Die Metallaphotokatalyse erfolgt ohne zusätzlichen Photokatalysator und verfügt über eine große Anwendungsbreite. Die Robustheit der photoinduzierten meta‐C‐H‐Funktionalisierung spiegelt sich in einer hohen Toleranz für funktionelle Gruppen wider und legt die Grundlage für anspruchsvolle, sekundäre und tertiäre meta‐C‐H‐Alkylierungen mittels Rutheniumphotoredox‐Katalyse.
Reduced‐order sliding function design for a class of nonlinear systems
Authors: Khimani Deepti , Patil Machhindranath , Bandyopadhyay Bijnan , Behera Abhisek K. 
Published: May 2019

AbstractIn this paper, the design of first order sliding mode control (SMC) and twisting control based on the reduced order sliding function is proposed for the robust stabilization of an class of uncertain nonlinear single‐input system. This method greatly simplifies the control design as the sliding function is linear, which is based on reduced order state vector. The nonlinear system is represented as a cascade interconnection of two subsystems driving and driven subsystems. Sliding surface and SMC are designed for only the driving subsystem that guarantees the asymptotic stability of the entire system. To show the effectiveness of the proposed control schemes, the simulation results of translational oscillator with rotational actuator are illustrated.
Bisimulations of boolean control networks with impulsive effects and its application in controllability
Authors: Zhang Qiliang , Feng Jun‐e , Wang Biao , Meng Min 
Published: May 2019

AbstractThis paper addresses the bisimulations of Boolean control networks (BCNs) with impulsive effects. First, by analyzing the state transitions of BCNs with impulsive effects, a necessary and sufficient condition for bisimulations is obtained. Second, by virtue of bisimulations, a premise for propagating complete controllability is proposed. Then, the structure characteristics of BCNs with impulsive effects propagating complete controllability are presented. Finally, two illustrative examples are provided to demonstrate the validity of the obtained results.
Multifunctional peptide‐based fluorescent chemosensor for detection of Hg2+, Cu2+ and S2− ions
Authors: Pang Xuliang , Wang Lei , Gao Lei , Feng Huiyun , Kong Jinming , Li Lianzhi 
Published: May 2019

AbstractA novel multifunctional fluorescent peptide sensor based on pentapeptide dansyl‐Gly‐His‐Gly‐Gly‐Trp‐COOH (D‐P5) was designed and synthesized efficiently using Fmoc solid‐phase peptide synthesis (SPPS). This fluorescent peptide sensor shows selective and sensitive responses to Hg2+ and Cu2+ among 17 metal ions and six anions studied in N‐2‐hydroxyethylpiperazine‐N‐2‐ethane sulfonic acid (HEPES) buffer solution. The peptide probe differentiates Hg2+ and Cu2+ ions by a ‘turn‐on’ response to Hg2+ and a ‘turn‐off’ response to Cu2+. Upon addition of Hg2+ or Cu2+ ions, the sensor displayed an apparent color change that was visible under an ultraviolet lamp to the naked eye. The limits of detection (LOD) of DP‐5 were 25.0 nM for Hg2+ and 85.0 nM for Cu2+; the detection limits for Cu2+ were much lower than the drinking water maximum contaminant levels set out by the United States Environmental Protection Agency (USEPA). It is noteworthy that both D‐P5‐Hg and D‐P5‐Cu systems were also used to detect S2− successfully based on the formation of ternary complexes. The LODs of D‐P5‐Hg and D‐P5‐Cu systems for S2− were 217.0 nM and 380.0 nM, respectively. Furthermore, the binding stoichiometry, binding affinity and pH sensitivity of the probe for Hg2+ and Cu2+ were investigated. This study gives new possibilities for using a short fluorescent peptide sensor for multifunctional detection, especially for anions.
Racial and ethnic disparities in a state‐wide registry of patients with pancreatic cancer and an exploratory investigation of cancer cachexia as a contributor to observed inequities
Authors: Permuth Jennifer B. , Clark Daly Ashley , Jeong Daniel , Choi Jung W. , Cameron Miles E. , Chen Dung‐Tsa , Teer Jamie K. , Barnett Tracey E. , Li Jiannong , Powers Benjamin D. , Kumar Nagalakshmi B. , George Thomas J. , Ali Karla N. , Huynh Tri , Vyas Shraddha , Gwede Clement K. , Simmons Vani N. , Hodul Pamela J. , Carballido Estrella M. , Judge Andrew R. , Fleming Jason B. , Merchant Nipun , Trevino Jose G. 
Published: May 2019

AbstractPancreatic cancer (PC) is characterized by racial/ethnic disparities and the debilitating muscle‐wasting condition, cancer cachexia. Florida ranks second in the number of PC deaths and has a large and understudied minority population. We examined the primary hypothesis that PC incidence and mortality rates may be highest among Black Floridians and the secondary hypothesis that biological correlates of cancer cachexia may underlie disparities. PC incidence and mortality rates were estimated by race/ethnicity, gender, and county using publicly available state‐wide cancer registry data that included approximately 2700 Black, 25 200 Non‐Hispanic White (NHW), and 3300 Hispanic/Latino (H/L) Floridians diagnosed between 2004 and 2014. Blacks within Florida experienced a significantly (P < 0.05) higher incidence (12.5/100 000) and mortality (10.97/100 000) compared to NHW (incidence = 11.2/100 000; mortality = 10.3/100 000) and H/L (incidence = 9.6/100 000; mortality = 8.7/100 000), especially in rural counties. To investigate radiologic and blood‐based correlates of cachexia, we leveraged data from a subset of patients evaluated at two geographically distinct Florida Cancer Centers. In Blacks compared to NHW matched on stage, markers of PC‐induced cachexia were more frequent and included greater decreases in core musculature compared to corresponding healthy control patients (25.0% vs 10.1% lower), greater decreases in psoas musculature over time (10.5% vs 4.8% loss), lower baseline serum albumin levels (3.8 vs 4.0 gm/dL), and higher platelet counts (332.8 vs 268.7 k/UL). Together, these findings suggest for the first time that PC and cachexia may affect Blacks disproportionately. Given its nearly universal contribution to illness and PC‐related deaths, the early diagnosis and treatment of cachexia may represent an avenue to improve health equity, quality of life, and survival.
Lysozyme nephropathy in chronic myelomonocytic leukemia
Authors: Patel Ami B. , Miles Rodney R. , Deininger Michael W. 
Published: May 2019

AbstractLysozyme nephropathy is a frequently unrecognized cause of renal disease in chronic myelomonocytic leukemia and may serve as a novel indication for treatment in this patient population. We demonstrate that in newly diagnosed CMML patients, plasma lysozyme levels are positively correlated with both absolute monocyte count and serum creatinine.
Three New Niccolites: High‐Temperature Phase Transitions, Prominent Anisotropic Thermal Expansions, Dielectric Anomalies, and Magnetism
Authors: Zhao Yin‐Hua , Liu Shu , Wang Bing‐Wu , Wang Zhe‐Ming , Gao Song 
Published: May 2019

AbstractThree new iso‐structural ammonium metal formates of [dmpnH2][M2(HCOO)6], in which dmpnH22+=N,N′‐dimethyl‐1,3‐propylenediammoium and M=divalent Co, Zn and Mg ions, are reported. They possess niccolite metal formate frameworks with long‐shaped cavities for the accommodation of dmpnH22+ cations. The three materials display reversible phase transitions of similar mechanism from ordered, antipolar or antiferroelectric, low‐temperature phases in space group C2/c, to disordered, paraelectric, high‐temperature phases in space group P
1c, with quite high critical temperatures of 366, 370, and 334 K for Co, Zn, and Mg members, respectively. On warming, the dmpnH22+ cation experiences an ordered state with gradual increase of the local vibration motions of the central CH2 and terminal CH3 groups, a partially disordered state with gradually enhanced flipping motion between the major and minor orientations, and finally a twisting or rotating motion after the phase transition, accompanied by prominent anisotropic thermal expansions and dielectric anomalies/relaxations. The phase transition characters and relevant properties also exhibit a subtle metal‐dependence. The Co member shows spin‐canted antiferromagnetism below the Néel temperature of 16.1 K, with unusual large spontaneous magnetization and coercive field.
Social recommendation: A user profile clustering‐based approach
Authors: Ouaftouh Sara , Zellou Ahmed , Idri Ali 
Published: May 2019

SummaryThe recommendation in information systems is a specific form of information filtering that aims to present the relevant information interesting the user. This technique is used in different contexts such as social networking, e‐commerce and information retrieval. Generally, existing recommender system techniques implement collaborative filtering by deducing a part of user interests from the preferences of other users with similar profiles. Many techniques can be used to implement Collaborative Filtering such as Bayesian Networks, latent semantic, and clustering. We present in this work a novel clustering approach using a modified partitional algorithm. We propose a user model that integrates the relevant user information and a clustering algorithm that generates groups of similar user profiles by implementing a profile similarity function. The proposed approach is then evaluated based on a set of user profiles data corresponding to the context of an e‐commerce website.
Data analysis and mining of traffic features based on taxi GPS trajectories: A case study in Beijing
Authors: Liu Chun , Wang Shuangyan , Cuomo Salvatore , Mei Gang 
Published: May 2019

SummaryTaxi GPS trajectories can be mined and used to optimize urban traffic scheduling. The optimization of traffic scheduling is important, especially in megacities such as Beijing. In this paper, we analyze the traffic features in Beijing by mining taxi GPS trajectories. We define the Congestion Coefficient of each edge of the taxi trajectory as the consumed time of a taxi running over a unit of distance. By analyzing the distribution of congestion coefficients of all taxi trajectories, we can observe that, on working days, (1) the congestion coefficient is between 0 and 2 (average speed is greater than 0.5 m/s) and is acceptable to taxi drivers, (2) the morning rush hours are 7:00 ∼ 10:00, (3) the evening rush hours are 17:00 ∼ 20:00, and (4) the traffic congestion in the morning rush hours is worse than that in the evening rush hours; on the weekend, (1) the congestion coefficient is less than 0.2 (average speed is greater than 5 m/s) and is acceptable to taxi drivers; (2) compared with the traffic congestion on working days, there are no significant morning rush hours on the weekend; and (3) the period of the time between 13:00 and 15:00 could be considered the traffic rush hours on the weekend. These findings can be used to improve urban traffic management.
Hepatitis B virus reactivation with corticosteroid therapy in patients with adrenal insufficiency
Authors: Hatano Masako , Mimura Toshihide , Shimada Akira , Noda Mitsuhiko , Katayama Shigehiro 
Published: May 2019

AbstractObjectiveWhether or not reactivation of hepatitis B virus (HBV) might occur during corticosteroid therapy in hepatitis B surface antigen (HBsAg)‐negative patients with adrenal insufficiency was investigated.Patients and MethodsWe consecutively enrolled 66 patients with adrenal insufficiency undergoing physiological corticosteroid replacement therapy at Saitama Medical University Hospital between June 2013 and June 2014, and 220 patients with rheumatic disease receiving a pharmacologic dose of corticosteroids served as the positive control group. The latter group was separated into 101 patients treated only with corticosteroids, and 119 patients given corticosteroids plus immunosuppressants and/or disease‐modifying antirheumatic drugs (DMARDs). HBsAg and antibody (Ab) levels against HBs, and hepatitis B core (HBc) were determined in all the patients. In patients with positive HBsAb and/or HBcAb, real‐time PCR was performed for HBV‐DNA. The incidence rates of conversion to HBV‐DNA‐positive status were evaluated.ResultsHepatitis B virus reactivation occurred in six patients with rheumatic disease, three of whom were receiving a pharmacological dose of corticosteroids only, and three who were receiving corticosteroids with immunosuppressants and/or DMARDs. However, no reactivation occurred in patients receiving corticosteroid replacements for adrenal insufficiency. Maintenance and maximum corticosteroid doses administered to patients with rheumatic disease were significantly greater than those in patients with adrenal insufficiency.ConclusionThese results suggest that, although corticosteroid replacement therapy for adrenal insufficiency might be safe with respect to HBV reactivation, attention should be paid to HBV reactivation during corticosteroid therapy in rheumatic disease patients, since the dose of corticosteroids administered is usually large, and since other immunosuppressants are co‐administered.
Empirical observations and numerical modelling of tides, channel morphology, and vegetative effects on accretion in a restored tidal marsh
Authors: Fleri Jesse R. , Lera Sara , Gerevini Alessandro , Staver Lorie , Nardin William 
Published: May 2019

AbstractTidal marshes form at the confluence between estuarine and marine environments where tidal movement regulates their developmental processes. Here, we investigate how the interplay between tides, channel morphology, and vegetation affect sediment dynamics in a low energy tidal marsh at the Paul S. Sarbanes Ecosystem Restoration Project at Poplar Island. Poplar Island is an active restoration site where fine‐grained material dredged from navigation channels in the upper Chesapeake Bay are being used to restore remote tidal marsh habitat toward the middle bay (Maryland, USA). Tidal currents were measured over multiple tidal cycles in the inlets and tidal creeks of one marsh at Poplar Island, Cell 1B, using Acoustic Doppler Current Profilers (ADCP) to estimate water fluxes throughout the marsh complex. Sediment fluxes were estimated using acoustic backscatter recorded by ADCPs and validated against total suspended solid measurements taken on site. A high‐resolution geomorphic survey was conducted to capture channel cross sections and tidal marsh morphology. We integrated simple numerical models built in Delft3d with empirical observations to identify which eco‐geomorphological factors influence sediment distribution in various channel configurations with differing vegetative characteristics. Channel morphology influences flood‐ebb dominance in marshes, where deep, narrow channels promote high tidal velocities and incision, increasing sediment suspension and reducing resilience in marshes at Poplar Island. Our numerical models suggest that accurately modelling plant phenology is vital for estimating sediment accretion rates. In‐situ observations indicate that Poplar Island marshes are experiencing erosion typical for many Chesapeake Bay islands. Peak periods of sediment suspension frequently coincide with the largest outflows of water during ebb tides resulting in large sediment deficits. Ebb dominance (net sediment export) in tidal marshes is likely amplified by sea‐level rise and may lower marsh resilience. We couple field observations with numerical models to understand how tidal marsh morphodynamics contribute to marsh resilience. © 2019 John Wiley & Sons, Ltd.
Volatility index and the return–volatility relation: Intraday evidence from Chinese options market
Authors: Li Jupeng , Yu Xiaoli , Luo Xingguo 
Published: May 2019

AbstractWe use unique intraday data to investigate the validity of the Shanghai Stock Exchange's the revised Chinese implied volatility index (iVX). We find that iVX is an effective barometer for the underlying exchange‐traded fund (ETF) market and can be used as a valid “fear index” when there is anxiety over large drops. Furthermore, we use robust quantile regressions and document the asymmetric relation between returns and iVX changes. We also show that behavioral theories offer better explanations for this asymmetric relation than do fundamental theories. More important, we examine the role of iVX in selecting trading strategies.
Which factors stimulate industrial green total factor productivity growth rate in China? An industrial aspect
Authors: Cui Herui , Wang Haoran , Zhao Qiaozhi 
Published: May 2019

AbstractAs an important evaluation transformation index, exploring green total factor productivity (GTFP) trend and related key factors is significant for China's economy entering into high‐quality development and green transformation. In this study, stochastic frontier analysis (SFA) and kernel density function are used to evaluate GTFP growth trend for 36 China's industrial sectors during 2000–2016, and system generalized method of moment is used to explore their key driving factors. The results are as follows: First, SFA supplies efficient estimation for GTFP growth information. The 36 industrial sectors are classified into three emission types, that is, high‐, moderate‐, and low emission. Second, GTFP growth differs significantly in three types of sectors. With kernel density results for 36 sectors, the curve of GTFP growth has shifted upward and toward the left since 2010. For high‐emission type sectors, their kernel curve has also moved upward and toward the left. The curve of moderate‐emission type sectors significantly shifted toward the left, whereas the curve of low‐emission type moved upward. Third, based on regression estimation results, environmental regulatory policy, resource input structure, foreign direct investment, and energy‐type structure significantly influence GTFP growth. Technology innovation makes insignificant impact on GTFP for industrial sectors. In conclusion, sectorial heterogeneity should be paid more focus in order to improve their growth, especially for high‐emission type sectors. Green technology innovation is the most potential factor in the future to stimulate GTFP growth in China. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd.
Plasma soluble programmed death ligand 1 levels predict clinical response in peripheral T‐cell lymphomas
Authors: Zhang Xuhan , Liu Lu , Zhou Shiyong , Zhao Kuo , Song Zheng , Hu Ge , Zhang Tingting , Li Yang , Qiu Lihua , Li Lanfang , Qian Zhengzi , Meng Bin , Pan Yi , Ren Xiubao , Wang Xianhuo , Zhang Huilai , Fu Kai 
Published: May 2019

AbstractImmune checkpoints, including PD‐1/PD‐L1, play an important role in immunosuppression in various malignancies. Elevated levels of soluble programmed death ligand 1 (sPD‐L1) are associated with worse prognosis in multiple myeloma and diffuse large B cell lymphoma. Herein, the purpose of this study is to investigate the relationships between plasma sPD‐L1 levels and clinical response in peripheral T‐cell lymphoma (PTCL) patients.A total of 37 PTCL patients and 20 healthy volunteers were enrolled. Peripheral blood from patients was collected prior to systemic therapy. Plasma levels of sPD‐L1 and IFN‐γ were measured by enzyme‐linked immunosorbent assay (ELISA). PD‐L1 expression in tissues was detected by immunohistochemistry (IHC). Clinical response for patients was evaluated.ONCOMINE database analyses showed that PD‐L1 mRNA expression was significantly upregulated in PTCLs. The median sPD‐L1 level was 0.729 ng/mL for 20 healthy volunteers and 1.696 ng/mL for 37 PTCL patients which was significantly higher than that in healthy volunteers (0.000). The sPD‐L1 level was positively correlated with IFN‐γ level (0.000, r = 0.849) and was also positively associated with clinical staging (0.045), LDH level (0.003), and β2‐MG level (0.045). Patients with high sPD‐L1 level had lower overall response rate than those with low sPD‐L1 level (88.9% vs 50.0%, 0.022) and tended to have poorer PFS and OS. PD‐L1 expression in tissues matched very well with the sPD‐L1 level in PTCL patients. In conclusion, PTCL patients had higher sPD‐L1 level compared with healthy volunteers. High sPD‐L1 level was correlated with worse clinical response, suggesting that sPD‐L1 level was an underlying plasma biomarker to predict the prognosis for PTCL patients.
Reproductive health sequelae among women who survived Ebola virus disease in Liberia
Authors: Godwin Christine L. , Wohl David A. , Fischer 2nd William A. , Singh Kavita , Hawks Darrell A. , Devore Elizabeth E. , Brown Jerry 
Published: May 2019

AbstractObjectiveTo estimate the incidence of failed pregnancy and menstrual irregularities among Liberian women who had survived Ebola virus disease (EVD) and to identify host‐specific and disease‐specific factors associated with these outcomes.MethodsA cross‐sectional questionnaire‐based study was conducted between August 10, 2016, and February 7, 2017. The study population comprised 111 women aged 18–45 years who had survived EVD and were enrolled in the Longitudinal Liberian Ebola Survivor study based at the Eternal Love Winning Africa Hospital, Monrovia, Liberia. Self‐reported data on outcomes related to pregnancy and menstrual changes since recovery from EVD were collected.ResultsIn all, 29 (26.1%) of the participants had become pregnant since surviving EVD. Of the 23 women whose pregnancies continued to term, 10 (43.4%) reported live birth, 11 (47.8%) reported spontaneous abortion, and two (8.7%) reported stillbirth. Of the 105 women who reported having regular menstruation before EVD, 27 (29.0%) reported experiencing irregular menstruation for unknown reasons after EVD. In bivariate logistic models, no associations were found between failed pregnancy or irregular menstruation and any of the factors of interest.ConclusionsAdverse pregnancy outcomes and irregular menstruation were frequently reported among EVD survivors in Liberia.
Epidermal growth factor receptor genes are overexpressed within the periprosthetic soft‐tissue around percutaneous devices: A pilot study
Authors: Jeyapalina Sujee , Colombo John S. , Beck James P. , Agarwal Jayant P. , Schmidt Linda A. , Bachus Kent N. 
Published: May 2019

AbstractEpidermal downgrowth around percutaneous devices produce sinus tracts, which then accumulate bacteria becoming foci of infection. This mode to failure is epidermal‐centric, and is accelerated by changes in the chemokines and cytokines of the underlying periprosthetic granulation tissue (GT). In order to more fully comprehend the mechanism of downgrowth, in this 28‐day study, percutaneous devices were placed in 10 Zucker diabetic fatty rats; 5 animals were induced with diabetes mellitus II (DM II) prior to the surgery and 5 animals served as a healthy, nondiabetic cohort. At necropsy, periprosthetic tissues were harvested, and underwent histological and polymerase chain reaction (PCR) studies. After isolating GTs from the surrounding tissue and extracting ribonucleic acids, PCR array and quantitative‐PCR (qPCR) analyses were carried‐out. The PCR array for 84 key wound‐healing associated genes showed a five‐fold or greater change in 31 genes in the GTs of healthy animals compared to uninjured healthy typical skin tissues. Eighteen genes were overexpressed and these included epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR). Thirteen genes were underexpressed. When GTs of DM II animals were compared to healthy animals, there were 8 genes overexpressed and 25 genes underexpressed; under expressed genes included EGF and EGFR. The qPCR and immunohistochemistry data further validated these observations. Pathway analysis of genes up‐regulated 15‐fold or more indicated two, EGFR and interleukin‐10, centric clustering effects. It was concluded that EGFR could be a key player in exacerbating the epidermal downgrowth, and might be an effective target for preventing downgrowth.