bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penser la surdité. L’histoire du sourd de Chartres et l’empirisme des Lumières
Authors: Chottin Marion 
Published: September 2018

En 1703, dans l’ Histoire de l’Académie royale des sciences , Fontenelle rapporte un petit récit concernant un jeune homme sourd de la ville de Chartres qui aurait soudainement recouvré l’audition : sorte d’analogue de l’adolescent aveugle auquel Cheselden rendit la vue en 1728, le « sourd et muet de Chartres », qui, sans langage, menait une « vie purement animale », viendrait prouver, selon Fontenelle, que « le plus grand fonds des idées des hommes est dans leur commerce réciproque ». Indissociable des enjeux théologiques et métaphysiques qu’elle charrie, cette histoire eut pour effet de hisser la surdité au rang d’objet philosophique. C’est pourquoi nous l’aborderons non pas comme un (simple) moyen susceptible de trancher le problème des rapports langage/pensée, mais comme un prisme révélateur des philosophies de la surdité du siècle des Lumières. Plus précisément, nous voudrions établir la thèse suivante : l’histoire du sourd de Chartres a été l’occasion, pour les philosophes empiristes, de produire le concept de surdité qui seul pouvait conduire à la généralisation de l’instruction des sourds, à savoir celui d’une privation purement circonstancielle et contingente de la raison.
Analyser les musiques actuelles : jalons pour une proposition de méthodologie
Authors: Gonin Philippe 
Published: September 2018

Il existe aujourd’hui encore une tendance très forte intégrant l’analyse des musiques actuelles, et en particulier des musiques rock, dans le carcan d’une analyse « traditionnelle », héritière de l’analyse tonale appliquée aux musiques savantes voire au jazz. Pourtant, celle-ci s’avère impuissante à décrire l’ensemble du phénomène sonore constituant une œuvre musicale « rock ». Par ailleurs, des études réalisées par des acousticiens révèlent des phénomènes sonores liés à la production, au mixage, mais font la plupart du temps abstraction de « l’écriture » musicale. Si l’on convient généralement que le « texte premier » ( primary text ) permettant d’analyser les musiques rock est l’enregistrement, que sa transmission est essentiellement phonographique, alors il nous faut chercher des pistes permettant de définir les contours d’une analyse intimement liée à l’enregistrement. Cette spécificité nous conduit à envisager une définition nouvelle et plus large des musiques rock comme œuvre distinguant une structure simple et ses diverses représentations que l’on peut appeler structures complexes. La présente contribution propose de poser quelques jalons visant à définir des propositions méthodologiques spécifiquement adaptées aux musique rock comme objet d’analyse.
Une organisation d’entreprise au service de la sûreté à l’international pour ses collaborateurs : le cas de Danone
Authors: Rimlinger Annick 
Published: September 2018

Après un parcours au sein de l’Aéronavale, Bernard Galéa rejoint un service spécialisé de la Défense où il alternera durant plus de 17 années des postes en administration centrale et à l’étranger. En 2008, il décide de rejoindre le privé : FM Logistic puis Danone en 2015 en tant que vice-président, directeur de la sûreté et de l’intelligence économique.	Diplômé d’un master en Gestion globale des risques et des crises (Paris 1, Panthéon-Sorbonne), 10 è promotion de l’IERSE-INHESJ Paris, il dispose également de deux executives certificates en General management (Wharton School, université de Pennsyvanie) et en Operation and supply chain management (Massachusetts Institute of Technology).	Bernard Galéa est membre du conseil d’administration du CDSE, VP de l’ASIS International pour le chapitre France et membre du board européen où il représente le CSO Roundtable. Il est Officier de la Légion d’Honneur et Conseiller du Commerce extérieur de la France.
The impairment of the Growth Hormone/Insulin-like growth factor 1 (IGF-1) axis in heart failure: A possible target for future therapy
Authors: Piccioli Lucrezia , Arcopinto Michele , Salzano Andrea , D'Assante Roberta , Schiavo Alessandra , Stagnaro Francesca M. , Lombardi Anna , Panicara Veronica , Valente Pietro , Vitale Giuseppe , Sarullo Filippo M. , Giallauria Francesco , Marra Alberto M. 
Published: September 2018

Hormonal abnormalities are quite common in chronic heart failure (CHF). The most studied hormonal axis in CHF is the impairment of Growth Hormone (GH)/Insulin Growth Factor-1(IGF-1), which in turn is defined either by a blunted response to GH stimulation test or low serum IGF-1 values. Â Several independent groups reported that the presence of an abnormal GH/IGF-1 status in CHF is associated with a more severe disease, impaired functional capacity and reduced Survival rates. After the first encouraging results, double -blind controlled trials showed a neutral effect of the GH administration in patients. However, further studies reported positive results, when a GH-therapy is implemented only in those patients presenting a GH deficiency (replacement therapy).
Bridging the Gap: Interdepartmental Quality Improvement and Patient Safety Curriculum Created by Hospital Leaders, Faculty, and Trainees
Authors: Miller Megan E. , Patel Ajanta , Schindler Nancy , Hirsch Kristen , Ming Mei , Weber Stephen , Turner Phyllis , Howell Michael D. , Arora Vineet M. , Oyler Julie L. 
Published: September 2018

ABSTRACT

Background
The Accreditation Council for Graduate Medical Education Clinical Learning Environment Review recommends that quality improvement/patient safety (QI/PS) experts, program faculty, and trainees collectively develop QI/PS education.

Objective
Faculty, hospital leaders, and resident and fellow champions at the University of Chicago designed an interdepartmental curriculum to train postgraduate year 1 (PGY-1) residents on core QI/PS principles, measuring outcomes of knowledge, attitudes, and event reporting.

Methods
The curriculum consisted of 3 sessions: PS, quality assessment, and QI. Faculty and resident and fellow leaders taught foundational knowledge, and hospital leaders discussed institutional priorities. PGY-1 residents attended during protected conference times, and they completed in-class activities. Knowledge and attitudes were assessed using pretests and posttests; graduating residents (PGY-3–PGY-8) were controls. Event reporting was compared to a concurrent control group of nonparticipating PGY-1 residents.

Results
From 2015 to 2017, 140 interns in internal medicine (49%), pediatrics (33%), and surgery (13%) enrolled, with 112 (80%) participating and completing pretests and posttests. Overall, knowledge scores improved (44% versus 57%, P &lt; .001), and 72% of residents demonstrated increased knowledge. Confidence comprehending quality dashboards increased (13% versus 49%, P &lt; .001). PGY-1 posttest responses were similar to those of 252 graduate controls for accessibility of hospital leaders, filing event reports, and quality dashboards. PGY-1 residents in the QI/PS curriculum reported more patient safety events than PGY-1 residents not exposed to the curriculum (0.39 events per trainee versus 0.10, P &lt; .001).

Conclusions
An interdepartmental curriculum was acceptable to residents and feasible across 3 specialties, and it was associated with increased event reporting by participating PGY-1 residents.
Levantamento Arbóreo Da Caatinga No Campus IV Da UEPB Em Catolé Do Rocha, PB
Authors: Guimarães Luciana Menino , LINHARES Anne Carolline Maia , SILVA Sonaria de Sousa , Da SILVA Damião Pedro , COSTA Fabiana Xavier 
Published: September 2018

RESUMO: O bioma Caatinga, é o maior e mais importante da Região Nordeste do Brasil. objetivou-se com esse trabalho quantificar as espécies arbóreas da UEPB Campus IV nos setores de Oleaginosas e do açude. O presente estudo foi realizado no Campus IV da Universidade Estadual da Paraíba no Município de Catolé do Rocha, a pesquisa se deu nos setores de Oleaginosas e setor do Açude. O total de árvores encontradas durante a presente pesquisa no setor de Oleaginosas foram de 1.645 indivíduos sendo 14 famílias, onde a família da Rosaceae (marmeleiro) apresenta-se em maior quantidade seguida da fabáceae (Feijão bravo) e Leguminosae (jurema preta e jurema branca). O total de árvores encontradas durante a presente pesquisa no setor do Açude foram de 51 indivíduos sendo 7 famílias, onde a família das Bignoniaceae (Pau d'arco) apresenta-se em maior quantidade seguida da Caesalpiniaceae (Mororó) e Leguminosae (jurema preta e jurema branca). As espécies estudadas apresentam as mesmas características fenológicas vistas para outras áreas de florestas da caatinga.
De afnemende rol van de rechtspraak: is vervanging van de rechter mogelijk en wenselijk?
Authors: Malsch Marijke 
Published: September 2018

The diminishing role of the Judiciary: is replacement of the judge possible and desirable?
The last decades have shown a tendency in which tasks are transferred from the judge to other authorities, such as the police and public prosecutor, administrative bodies, administrative procedures, or private parties. The central question in this article is whether these authorities can really replace the court. A comparison is made between legal proceedings and procedures for other authorities on the following aspects: truth finding, openness and legal protection of the (vulnerable) citizen. The author also discusses a recent legislative proposal for an own budget for the Judiciary, which aims to strengthen the independence of the judge towards the two other state powers. It is argued that the courts should be also accessible in the case of relatively small offenses and for vulnerable citizens.
Het zwaard van Damocles: burgemeesters wil is wet
Authors: Schaap Maartje 
Published: September 2018

Damocles law: On the punitive nature of an administrative measure in the Netherlands
Under Article 13b (1) of the Dutch Opium Act, the mayor is authorized to impose an order under administrative coercion when drugs are sold, delivered, supplied or present in houses or premises This much-discussed article, also cited as the ‘Damocles Law’, gives the mayor the power to close drug shelters even before the suspect’s guilt has been established in legal proceedings. It is not necessary to show that the interests of public policy are at stake. Moreover, the means of defense against the closure are very limited. The author argues that the current application of Article 13b is exclusively punitive in nature, whereby in case of criminal prosecution, there is also a violation of the ne bis in idem principle.
Tirkkonen: besluiteloosheid wordt beloond?
Authors: Nijhof B. 
Published: September 2018

Tirkkonen: besluiteloosheid wordt beloond?
Het Hof van Justitie oordeelt dat Aanbestedingsrichtlijn 2004/18/EG geen toepassing vindt bij een systeem waar potentiële opdrachtnemers slechts hoeven te voldoen aan toelatingseisen, zonder dat de aanbestedende dienst uiteindelijk een keuze maakt voor specifieke opdrachtnemers op basis van onderscheidende criteria. Daarbij is het irrelevant dat dat systeem niet ‘open house’ is.HvJ 1 maart 2018, zaak C-9/17, Maria Tirkkonen/Maaseutuvirasto, ECLI:EU:C:2018:142
Terugvordering van staatssteun vindt zijn plek in de Nederlandse wetgeving
Authors: van Haersolte J.C. 
Published: September 2018

Terugvordering van staatssteun vindt zijn plek in de Nederlandse wetgeving
Per 1 juli 2018 heeft het staatssteunrecht zijn plek gevonden in de Nederlandse regelgeving. Althans, de terugvordering van onrechtmatige staatssteun. Wat regelt de Wet terugvordering staatssteun?Wet Terugvordering staatssteun (in werking getreden op 1 juli 2018), Stb. 2018, 99
Donald J. Trump: un análisis crítico del discurso
Authors: Mena García Tomás 
Published: September 2018

Donal J. Trump resulta ser un Presidente fuera de lo común que genera polémicos titulares en todo el mundo. ¿Por qué provoca tanta atracción y polémica? ¿Qué novedades aporta? Este estudio pretende responder a estas cuestiones desde una perspectiva del análisis crítico del discurso. El ensayo está dividido en tres capítulos. En el primero se exponen los aspectos más característicos de su estilo discursivo. El segundo se dedica a estudiar la influencia de los modelos de familia en Trump analizados por el lingüista cognitivo George Lakoff, centrándose en los siguientes tipos: el Padre estricto y el Progenitor nutriente. El tercero y último capítulo se consagra a estudiar el modo en que “el otro” es representado por Trump. Se aborda en este trabajo el tratamiento de temas como el racismo, la inmigración o su visión de “la clase dirigente”. Donald J. Trump is an “off the spectrum” President who creates controversial headlines of the media around the world. Where does his appeal come from? What is new about him? This paper tries to answer these questions from a Critical Discourse Analysis perspective. The essay is divided into three chapters. The first one gives a general overview of Trump’s discourse styles. The second one deals with the family model developed by George Lakoff in terms of metaphors and more specifically with the representation of the strict father pattern in Trump’s discourse. The third and final chapter is dedicated to the portrayal of “the other” in Trump. Strategies to depict “otherness” are analysed from an ideological discourse viewpoint. Racism, immigration and Trump’s depiction of “the establishment” are not neglected.
Protocolo y Relaciones Institucionales
Authors: Merchán Rodriguez M.ª de los Ángeles 
Published: September 2018

La consecución de objetivos se produce tras un proceso de desarrollo y potenciación de las competencias. Ahora bien, ¿y si existiese una metodología que nos permitiese conectar con nuestro propio liderazgo, desarrollar nuestras potencialidades y manifestar la excelencia? ¿Y si esta metodología fuese aplicada de forma específica por y para los profesionales del Protocolo? ¿Y, además, tuviese un beneficio directo sobre la actividad de Relaciones Públicas de la organización? El objetivo de esta comunicación es aportar a los protocolistas distintas herramientas y una metodología específica que les faculte para el desarrollo de un nuevo liderazgo para el s.XXI. En la realización de este proceso obtendrán un beneficio personal que reportará directamente sobre las organizaciones para las que trabajan.________________________________The achievement of objectives happens after a process of development and empowerment of competencies. Now, what if there were a methodology that allowed us to connect with our own leadership, develop our potential and manifest excellence? What if this methodology were applied specifically by and for the professionals of Protocol? And, besides, had a direct benefit on the activity of Public Relations of the organization? The objective of this communication is to provide the protocolists with different tools and a specific methodology that enables them to develop a new leadership for the XXI century. Carrying out this process, you will obtain a personal benefit that will directly report to the organizations for which you work.
Genetics of Modern Human Origins and Diversity
Authors: Relethford John H. 
Published: September 2018

The fossil record, genetic data from present‐day human populations, and ancient DNA all support a model of human evolution where modern humans arose in Africa 200,000 years ago, and began dispersing throughout the world in the past 100,000 to 50,000 years, along with some interbreeding with earlier human populations, such as the Neanderthals. Patterns of genetic diversity within and between present‐day human populations reflect this history, including higher levels of genetic diversity in sub‐Saharan African populations, a decrease in genetic diversity with increasing distance from East Africa, and a strong correlation of genetic differences with the geographic distance between populations.
Rapid Soft Tissue Approximation and Repair Using Laser‐Activated Silk Nanosealants
Authors: Urie Russell , Guo Chengchen , Ghosh Deepanjan , Thelakkaden Mitzi , Wong Valerie , Lee Jung Keun , Kilbourne Jacquelyn , Yarger Jeffery , Rege Kaushal 
Published: September 2018

AbstractTissue approximation and repair are conventionally performed with sutures and staples, but these means are inherently traumatic. Tissue approximation using laser‐responsive nanomaterials can lead to rapid tissue sealing and repair, and is an attractive alternative to existing clinical methods. Here, the use of laser‐activated nanosealants (LANS) with gold nanorods (GNRs) embedded in silk fibroin polypeptide matrices is demonstrated. The adaptability of LANS for sealing soft tissues is demonstrated using two different modalities: insoluble thin films for internal, intestinal tissue repair, and semisoluble pastes for external repair, shown by skin repair in live mice. Laser repaired intestinal tissue held over seven times more fluid pressure than sutured intestine and also prevented bacterial leakage. Skin incisions in mice closed using LANS' showed indication of increased mechanical strength and faster repair compared to suturing. Laser‐activated silk‐GNR nanosealants rapidly seal soft‐tissue tears and show high promise for tissue approximation and repair in trauma and routine surgery.
Architectural Design of Self‐Assembled Hollow Superstructures
Authors: Xue Zhenjie , Wang Peilong , Peng Aidong , Wang Tie 
Published: September 2018

AbstractColloidal nanoparticle assemblies are widely designed and fabricated via various building blocks to enhance their intrinsic properties and potential applications. Self‐assembled hollow superstructures have been a focal point in nanotechnology for several decades and are likely to remain so for the foreseeable future. The novel properties of self‐assembled hollow superstructures stem from their effective spatial utilization. As such, a comprehensive appreciation of the interactive forces at play among individual building blocks is a prerequisite for designing and managing the self‐assembly process, toward the fabrication of optimal hollow nanoproducts. Herein, the emerging approaches to the fabrication of self‐assembled hollow superstructures, including hard‐templated, soft‐templated, self‐templated, and template‐free methods, are classified and discussed. The corresponding reinforcement mechanisms, such as strong ligand interaction strategies and extra‐capping strategies, are discussed in detail. Finally, possible future directions for the construction of multifunctional hollow superstructures with highly efficient catalytic reaction systems and an integration platform for bioapplications are discussed.
Enhanced Thermal Boundary Conductance in Few‐Layer Ti3C2 MXene with Encapsulation
Authors: Yasaei Poya , Hemmat Zahra , Foss Cameron J. , Li Shixuan Justin , Hong Liang , Behranginia Amirhossein , Majidi Leily , Klie Robert F. , Barsoum Michel W. , Aksamija Zlatan , Salehi‐Khojin Amin 
Published: September 2018

AbstractVan der Waals interactions in 2D materials have enabled the realization of nanoelectronics with high‐density vertical integration. Yet, poor energy transport through such 2D–2D and 2D–3D interfaces can limit a device's performance due to overheating. One long‐standing question in the field is how different encapsulating layers (e.g., contact metals or gate oxides) contribute to the thermal transport at the interface of 2D materials with their 3D substrates. Here, a novel self‐heating/self‐sensing electrical thermometry platform is developed based on atomically thin, metallic Ti3C2 MXene sheets, which enables experimental investigation of the thermal transport at a Ti3C2/SiO2 interface, with and without an aluminum oxide (AlOx) encapsulating layer. It is found that at room temperature, the thermal boundary conductance (TBC) increases from 10.8 to 19.5 MW m−2 K−1 upon AlOx encapsulation. Boltzmann transport modeling reveals that the TBC can be understood as a series combination of an external resistance between the MXene and the substrate, due to the coupling of low‐frequency flexural acoustic (ZA) phonons to substrate modes, and an internal resistance between ZA and in‐plane phonon modes. It is revealed that internal resistance is a bottle‐neck to heat removal and that encapsulation speeds up the heat transfer into low‐frequency ZA modes and reduces their depopulation, thus increasing the effective TBC.
Super‐resolution Geometric Barcoding for Multiplexed miRNA Profiling
Authors: Xu Weidong , Yin Peng , Dai Mingjie 
Published: September 2018

AbstractMicroRNA (miRNA) expression profiles hold promise as biomarkers for diagnostics and prognosis of complex diseases. Herein, we report a super‐resolution fluorescence imaging‐based digital profiling method for specific, sensitive, and multiplexed detection of miRNAs. In particular, we applied the DNA‐PAINT (point accumulation for imaging in nanoscale topography) method to implement a super‐resolution geometric barcoding scheme for multiplexed single‐molecule miRNA capture and digital counting. Using synthetic DNA nanostructures as a programmable miRNA capture nano‐array, we demonstrated high‐specificity (single nucleotide mismatch discrimination), multiplexed (8‐plex, 2 panels), and sensitive measurements on synthetic miRNA samples, as well as applied one 8‐plex panel to measure endogenous miRNAs levels in total RNA extract from HeLa cells.
Bottom‐Up Construction of an Adaptive Enzymatic Reaction Network
Authors: Helwig Britta , van Sluijs Bob , Pogodaev Aleksandr A. , Postma Sjoerd G. J. , Huck Wilhelm T. S. 
Published: September 2018

AbstractThe reproduction of emergent behaviors in nature using reaction networks is an important objective in synthetic biology and systems chemistry. Herein, the first experimental realization of an enzymatic reaction network capable of an adaptive response is reported. The design is based on the dual activity of trypsin, which activates chymotrypsin while at the same time generating a fluorescent output from a fluorogenic substrate. Once activated, chymotrypsin counteracts the trypsin output by competing for the fluorogenic substrate and producing a non‐fluorescent output. It is demonstrated that this network produces a transient fluorescent output under out‐of‐equilibrium conditions while the input signal persists. Importantly, in agreement with mathematical simulations, we show that optimization of the pulse‐like response is an inherent trade‐off between maximum amplitude and lowest residual fluorescence.
Local and Global Dynamics in Intrinsically Disordered Synuclein
Authors: Rezaei‐Ghaleh Nasrollah , Parigi Giacomo , Soranno Andrea , Holla Andrea , Becker Stefan , Schuler Benjamin , Luchinat Claudio , Zweckstetter Markus 
Published: September 2018

AbstractIntrinsically disordered proteins (IDPs) experience a diverse spectrum of motions that are difficult to characterize with a single experimental technique. Herein we combine high‐ and low‐field nuclear spin relaxation, nanosecond fluorescence correlation spectroscopy (nsFCS), and long molecular dynamics simulations of alpha‐synuclein, an IDP involved in Parkinson disease, to obtain a comprehensive picture of its conformational dynamics. The combined analysis shows that fast motions below 2 ns caused by local dihedral angle fluctuations and conformational sampling within and between Ramachandran substates decorrelate most of the backbone N−H orientational memory. However, slow motions with correlation times of up to ca. 13 ns from segmental dynamics are present throughout the alpha‐synuclein chain, in particular in its C‐terminal domain, and global chain reconfiguration occurs on a timescale of ca. 60 ns. Our study demonstrates a powerful strategy to determine residue‐specific protein dynamics in IDPs at different time and length scales.