bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship of perivascular adipose tissue and atherosclerosis in the aorta and carotid arteries, determined by magnetic resonance imaging
Authors: Alkhalil Mohammad , Edmond Evan , Edgar Laurienne , Digby Janet E , Omar Omar , Robson Matthew D , Choudhury Robin P 
Published: February 2018

Background and aims: Imaging studies have relied on the ‘overall’ volumetric quantification of perivascular adipose tissue. We sought to assess the relationship of circumferential distribution between perivascular adipose tissue and adjacent wall thickness of carotid and aortic arteries using dedicated magnetic resonance imaging sequences. Methods: Vessel wall and perivascular adipose tissue were acquired using magnetic resonance imaging (1.5 T). Co-registered images were segmented separately, and measurements of both perivascular adipose tissue and vessel wall were obtained along radii of the vessel spaced at angles of 5° each. Results: In total, 29 patients were recruited. Perivascular adipose tissue thickness of the aorta was 3.34 ± 0.79 mm with specific pattern of ‘double peaks’ distribution, while carotid perivascular adipose tissue had no identifiable pattern with thickness of 0.8 ± 0.91 mm. Although statistically significant, the correlation between perivascular adipose tissue thickness and wall thickness in carotid arteries with normal (r = 0.040, p = 0.001) or with abnormal wall thickness (r = –0.039, p = 0.015) was merely nominal. Similarly, perivascular adipose tissue of the aorta had very weak correlation with normal aortic wall thickness (r = 0.010, p = 0.008) but not with the abnormal ones (r = −0.05, p = 0.29). Conclusion: Dissociation between the spatial distribution of perivascular adipose tissue and arterial wall thickening in the aorta and carotid arteries does not support that perivascular adipose tissue has a causal role in promoting atherosclerotic plaque via a paracrine route. Yet, perivascular adipose tissue functional properties were not examined in this study.
When Feelings Matter: Affect as a Mediator Between Motivational Regulation and Work Intentions
Authors: Lion Robert W. , Burch Tyler 
Published: February 2018

The Problem. Human resource development (HRD) scholars and practitioners alike are faced with the challenging task of accounting for the variables that influence the efficacy of the person in the workplace. Without a better understanding of the nature of the relationships between cognition and affect within the work domain, practitioners continue to struggle with accurately understanding how an individual’s motivational regulation impacts work intentions and organizational performance. The Solution. This study aims to provide new information on the mediating role state-specific affect plays in workplace-specific motivational outlooks to aid scholars and practitioners in more effectively diagnosing performance deficiencies, as well as influencing the selection and design of more-appropriate and sustainable performance improving interventions. The Stakeholders. Professionals in positions of power and influence are tasked with leading their people to meet organizational goals and outcomes. Without consideration of the various factors that may influence employee behaviors, such as motivational outlooks and state affect, leaders risk misappropriating valuable resources, such as time and energy.
Rapid increases in nitrogen oxides are associated with acute myocardial infarction: A case-crossover study
Authors: Rasche Marius , Walther Mario , Schiffner Rene , Kroegel Nasim , Rupprecht Sven , Schlattmann Peter , Schulze P Christian , Franzke Peter , Witte Otto W , Schwab Matthias , Rakers Florian 
Published: February 2018

Aims High concentrations of air pollutants are associated with increased risk for myocardial infarction. The European Union has defined statutory limits for air pollutants based on upper absolute concentrations. We evaluated the association between rapid changes in air pollutants and the risk of myocardial infarction independently of absolute concentrations. Methods and results Using a hospital-based case-crossover study, effects of 24h changes of nitrogen oxides (NOX/2), particulate matter (PM10), and ozone on the risk of myocardial infarction was assessed in 693 patients. In the overall population, increases of NOX of more than 20 µg/m3 within 24 h were associated with an increase in the risk of myocardial infarction by up to 121% (odds ratio (OR) 2.21, 95% confidence interval (CI) 1.19–4.08). Comparably, rapid increases of NO2 of more than 8 µg/m3 tended to increase myocardial infarction risk by 73% (OR 1.73, 95% CI 0.91–3.28) while myocardial infarction risk decreased by 60% after a decrease of NO2 concentration of more than 8 µg/m3 (OR 0.4, 95% CI 0.21–0.77), suggesting a close-to-linear association. While results for ozone concentrations were ambiguous, rapid change in PM10 was not associated with myocardial infarction risk. Conclusion Dynamics and extent of increase in nitrogen oxide concentrations may be an independent risk factor for myocardial infarction. As there are currently no European Union statutory limits reflecting this dynamic variation of air pollutants on a daily basis, the results urgently call for confirming studies in different geographical regions to verify the observations.
Primary Combined Pars Plana Vitrectomy and Phacoemulsification With Anterior Segment Removal of Posterior Segment Intraocular Foreign Bodies: A 30-Month Longitudinal Study
Authors: Coussa Razek Georges , Antaki Fares , Dirani Ali , Cordahi Thomas , Ajlan Radwan , Cordahi Ghassan 
Published: February 2018

Purpose: To describe a surgical technique and report visual and anatomical outcomes after primary combined pars plana vitrectomy (PPV) and phacoemulsification in patients with posterior segment intraocular foreign bodies (IOFBs) removed via the anterior chamber without enlarging preexisting sclerotomies. Posterior IOFBs are generally managed in a stepwise surgery consisting of phacoemulsification/lensectomy for traumatic cataract removal then PPV and removal of IOFB through enlarged sclerotomies. Enlarged sclerotomies may carry a significant risk of hypotony, vitreous hemorrhage, vitreous and retinal incarceration, and rhegmatogenous retinal detachment with proliferative vitreoretinopathy. Limited studies exist on long-term results of primary anterior segment removal of posterior IOFB combined with primary phacoemulsification. Methods: Medical records of consecutive patients who had ocular lacerations and posterior segment IOFB between October 2003 and June 2017 in a university hospital were reviewed. Patients who received a combined primary IOFB removal and phacoemulsification were included in the study. The postoperative evolution including visual acuity and complications were all recorded. Results: Thirteen patients (13 eyes) were included in the study. All patients were men, and the average age at presentation was 38 years. All IOFB were metallic, and their size ranged from 2 to 7 mm. All patients were operated within 24 hours of presentation. Six (46%) of the 13 lacerations were corneal, and 7 (54%) were scleral. Overall, 9 of 13 (69%) had a final postoperative best-corrected visual acuity equal to or better than 20 of 25. There were 3 (23%) postoperative complications of recurrent rhegmatogenous retinal detachment that occurred within the first postoperative year. Conclusion: Primary combined PPV and phacoemulsification with the removal of IOFB via the anterior segment is a safe and promising approach for repairing open globe injuries. Our results demonstrate the favorable prognostic benefit of this technique, which is recommended in cases with small corneal laceration and posterior segment pathology resulting from IOFB.
Immune evasion via PD-1/PD-L1 on NK cells and monocyte/macrophages is more prominent in Hodgkin lymphoma than DLBCL
Authors: Vari Frank , Arpon David , Keane Colm , Hertzberg Mark S. , Talaulikar Dipti , Jain Sanjiv , Cui Qingyan , Han Erica , Tobin Josh , Bird Robert , Cross Donna , Hernandez Annette , Gould Clare , Birch Simone , Gandhi Maher K. 
Published: February 2018

Key Points
Expansion of PD-1+ CD3−CD56hiCD16-ve NK cells and PD-L1+ monocytes/macrophages is more prominent in cHL than DLBCL. PD-1 blockade reverses the immune evasion mediated by the interaction of PD-1+ NK cells and PD-L1+ monocytes/macrophages.
Role of Bruton’s tyrosine kinase in B cells and malignancies
Authors: Pal Singh Simar , Dammeijer Floris , Hendriks Rudi W. 
Published: February 2018

AbstractBruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was initially shown to be defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) and is essential both for B cell development and function of mature B cells. Shortly after its discovery, BTK was placed in the signal transduction pathway downstream of the B cell antigen receptor (BCR). More recently, small-molecule inhibitors of this kinase have shown excellent anti-tumor activity, first in animal models and subsequently in clinical studies. In particular, the orally administered irreversible BTK inhibitor ibrutinib is associated with high response rates in patients with relapsed/refractory chronic lymphocytic leukemia (CLL) and mantle-cell lymphoma (MCL), including patients with high-risk genetic lesions. Because ibrutinib is generally well tolerated and shows durable single-agent efficacy, it was rapidly approved for first-line treatment of patients with CLL in 2016. To date, evidence is accumulating for efficacy of ibrutinib in various other B cell malignancies. BTK inhibition has molecular effects beyond its classic role in BCR signaling. These involve B cell-intrinsic signaling pathways central to cellular survival, proliferation or retention in supportive lymphoid niches. Moreover, BTK functions in several myeloid cell populations representing important components of the tumor microenvironment. As a result, there is currently a considerable interest in BTK inhibition as an anti-cancer therapy, not only in B cell malignancies but also in solid tumors. Efficacy of BTK inhibition as a single agent therapy is strong, but resistance may develop, fueling the development of combination therapies that improve clinical responses. In this review, we discuss the role of BTK in B cell differentiation and B cell malignancies and highlight the importance of BTK inhibition in cancer therapy.
Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity
Authors: Lee Ho Jin , Pham Phuong Chi , Hyun Seung Yeob , Baek Byungyeob , Kim Byungjin , Kim Yunha , Min Hye-Young , Lee Jeeyeon , Lee Ho-Young 
Published: February 2018

Abstract
Background
Both the type I insulin-like growth factor receptor (IGF1R) and Src pathways are associated with the development and progression of numerous types of human cancer, and Src activation confers resistance to anti-IGF1R therapies. Hence, targeting both IGF1R and Src concurrently is one of the main challenges in combating resistance to the currently available anti-IGF1R-based anticancer therapies. However, the enhanced toxicity from this combinatorial treatment could be one of the main hurdles for this strategy, suggesting the necessity of developing a novel strategy for co-targeting IGF1R and Src to meet an urgent clinical need.

Methods
We synthesized a series of 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitors, selected LL28 as an active compound and evaluated its potential antitumor effects in vitro and in vivo using the MTT assay, colony formation assays, flow cytometric analysis, a tumor xenograft model, and the Kras
G12D/+
-driven spontaneous lung tumorigenesis model.

Results
LL28 markedly suppressed the activation of IGF1R and Src and significantly inhibited the viability of several NSCLC cell lines in vitro by inducing apoptosis. Administration of mice with LL28 significantly suppressed the growth of H1299 NSCLC xenograft tumors without overt toxicity and substantially reduced the multiplicity, volume, and load of lung tumors in the Kras
G12D/+
-driven lung tumorigenesis model.

Conclusions
The present results suggest the potential of LL28 as a novel anticancer drug candidate targeting both IGF1R and Src, providing a new avenue to efficient anticancer therapies. Further investigation is warranted in advanced preclinical and clinical settings.
Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration
Authors: Missinato Maria A. , Saydmohammed Manush , Zuppo Daniel A. , Rao Krithika S. , Opie Graham W. , Kühn Bernhard , Tsang Michael 
Published: February 2018

ABSTRACT
Zebrafish regenerate cardiac tissue through proliferation of pre-existing cardiomyocytes and neovascularization. Secreted growth factors such as FGFs, IGF, PDGFs and Neuregulin play essential roles in stimulating cardiomyocyte proliferation. These factors activate the Ras/MAPK pathway, which is tightly controlled by the feedback attenuator Dual specificity phosphatase 6 (Dusp6), an ERK phosphatase. Here, we show that suppressing Dusp6 function enhances cardiac regeneration. Inactivation of Dusp6 by small molecules or by gene inactivation increased cardiomyocyte proliferation, coronary angiogenesis, and reduced fibrosis after ventricular resection. Inhibition of Erbb or PDGF receptor signaling suppressed cardiac regeneration in wild-type zebrafish, but had a milder effect on regeneration in dusp6 mutants. Moreover, in rat primary cardiomyocytes, NRG1-stimulated proliferation can be enhanced upon chemical inhibition of Dusp6 with BCI. Our results suggest that Dusp6 attenuates Ras/MAPK signaling during regeneration and that suppressing Dusp6 can enhance cardiac repair.
GAC: Gene Associations with Clinical, a web based application
Authors: Zhang Xinyan , Rupji Manali , Kowalski Jeanne 
Published: February 2018

We present GAC, a shiny R based tool for interactive visualization of clinical associations based on high-dimensional data. The tool provides a web-based suite to perform supervised principal component analysis (SuperPC), an approach that uses both high-dimensional data, such as gene expression, combined with clinical data to infer clinical associations. We extended the approach to address binary outcomes, in addition to continuous and time-to-event data in our package, thereby increasing the use and flexibility of SuperPC. Additionally, the tool provides an interactive visualization for summarizing results based on a forest plot for both binary and time-to-event data. In summary, the GAC suite of tools provide a one stop shop for conducting statistical analysis to identify and visualize the association between a clinical outcome of interest and high-dimensional data types, such as genomic data. Our GAC package has been implemented in R and is available via http://shinygispa.winship.emory.edu/GAC/. The developmental repository is available at https://github.com/manalirupji/GAC.
Faithful Strategies: How Religion Shapes Nonprofit Management
Authors: Filistrucchi Lapo , Prüfer Jens 
Published: February 2018

This paper studies the strategies employed by Catholic and Protestant nonprofit hospitals in Germany and traces them back to the theological foundations of those religions. Using a unique data set, we find that Catholic nonprofit hospitals follow a strategy of horizontal diversification and maximization of the number of patients treated. By contrast, Protestant hospitals pursue a strategy of horizontal specialization and focus on vertical differentiation, putting in more sophisticated inputs and producing more complex services. These effects increase if the environment of a hospital gets more competitive. We present a model that rationalizes the strategic differences as a result of the difference between Catholic and Protestant values identified in the literature. We then test alternative explanations to the observed empirical differences and show that none of them is supported by the data. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2945 . This paper was accepted by Olav Sorenson, organizations.
A Low-Cost Spot Laser and Camera System for Fluorescent Dye Detection of Agricultural Aircraft Pattern Collection Strings
Authors: Price Randy R. 
Published: February 2018

Abstract. A low-cost dye detection system was developed for pattern testing agricultural aircraft. The system uses a green laser pointer, a USB web camera outfitted with a standard rhodamine filter, and software to threshold the images. When arranged in a 90° illumination chamber, the system was able to detect spray patterns on strings that matched patterns derived from a standard WRK fluorometer system with a numerical comparison of 85% and a coefficient of variation of 17%. Visual assessment indicated an 86% match and all major peaks, valleys, and patterns were correctly indicated. A field test with the system indicated that correct airplane adjustments were possible with the system and advantages include that it is easy-to-build, composed of low-cost components, and the operator can see the string fluorescence during analysis. This system may provide an alternate dye detection system for pattern testing strings from agricultural aircraft. Keywords: Aerial application, Collectors, Fluorescence, Lasers, Spray Deposition.
QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model
Authors: Firdayani Firdayani , Kusumaningrum Susi , Utomo Doddy Irawan Setyo , Wibowo Agung Eru , Chaidir Chaidir 
Published: February 2018

Rocaglamide derivatives are the compounds which have featuring cyclopenta[b]tetra-hydrobenzofuran skeleton. Until now it includes more than 50 naturally occurring derivatives. They were chosen to be interesting candidates for possible therapeutic agents primarily in the field of cancer chemotherapy due to their cytotoxic activities data against various cancer cells. A quantitative structure activity relationship (QSAR) studies were done to investigate physicochemical properties of molecule which contribute to their activities. Series of rocaglamide derivatives have been used and analyzed using linear free energy regression Hansch model for their cytotoxic activities against MONO-MAC-6 leukemia cells, RAJI lymphoma cells and MEL-JUSO melanoma cells. Results showed that the best QSAR equations were revealed involving C Log P and CMR parameters with nonlinear regression relationships in cytotoxic activities of rocaglamide derivatives against cancer cells above. Keywords: QSAR, Rocaglamide, LFER Hansch
Apoptosis and Antioxidant Activities of Catharanthus rosues [L] G.Don Extract on Breast Cancer Cell Line
Authors: Widowati Wahyu , Mozef Tjandrawati , Risdian Chandra , Ratnawati Hana , Tjahyani Susi , Sandra Ferry 
Published: February 2018

Tapak dara or Madagascar Periwinkle (Catharanthus roseus [L] G.Don), a natural plant, is empirically reported to have promising anticancer activity. To elucidate its mechanism, a research was conducted to investigate the possible ethanol extract of C. roseus in inducing apoptosis on breast cancer cell line (T47D). Antioxidant activity of C. roseus was investigated as well. Sub-G1 flowcytometric apoptotic analysis result showed that extract of C. roseus at 6.25 μg/mL induced apoptosis for 26.365%. Increasing extract concentration resulted an increasing apoptotic level as well, extract at concentration of 12.5 μg/mL induced apoptosis for 22.235%. Meanwhile doxorubicin at concentration of 10 μg/mL induced apoptosis for 36.055%. The antioxidant activity was determined by using in vitro assay: inhibition of 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Antioxidant activity of C. roseus extract were compared to quercetin and butylated hydroxyanisol (BHA), as positive controls. The results showed that DPPH IC50 of C. roseus extract, quercetin and BHA were 358.411 μg/mL, 19.200 μg/mL and 94.178 μg/mL, respectively. We suggest that C. roseus extract had a potential anticancer activity by inducing apoptosis.Key words : antioxidant, DPPH, Catharanthus roseus, apoptosis, breast cancer, T47D
Determination of The Active Asiaticoside Content in Centella asiatica as Anti-Cellulite Agent
Authors: Sondari Dewi , Harmami Sri Budi , Ghozali M. , Randy Ahmad , S. Athanasia Amanda , Irawan Yan 
Published: February 2018

Centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins, collectively known as centelloids. These terpenoids include asiaticoside, centelloside, madecassoside, brahmoside, brahminoside, thankuniside, sceffoleoside, centellose, asiatic-, brahmic-, centellic- and madecassic acids. Preparations of C. asiatica are used in traditional and alternative medicine due to the wide spectrum of pharmacological activities associated with these secondary metabolites, such as anticellulite agent. Asiaticoside was found in Centella asiatica. In this present study, the asiaticoside was extracted using methanolic and ethanolic solvent. Determination of the asiaticoside content in the extract was conducted with High Performance Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), and Fourier Transform Infra Red (FTIR). Samples of C. asiatica used in this study came from three different plantation areas, Bogor, Lembang and Solo. Asiaticoside content in the methanolic extract from Bogor, Lembang, and Solo samples were 2.82%; 2.68%; and 2.8% respectively. Asiaticoside in ethanolic extract from Bogor, Lembang, and Solo samples were 2.79%; 2.75%; and 2.91% respectively. Two way ANOVA study showed that there was significant difference between types of solvent used in extraction and the asiaticoside content in the obtained extract, significant difference between varied plantation area and obtained asiaticoside content, and significant difference between interactions of different solvent with different plantation area. Keywords: Centella asiatica, asiaticoside, anticellulite, medicine, metabolites
Combination of Curcuma (Curcuma xanthorriza Roxb) Rhizome Ethanolic Extract and Awar-Awar (Ficus septica Burm.F) Leaves Ethanolic Extract Increases Cisplatin Cytotoxicity on T47D Breast Cancer Cells through Cell Cycle Modulation
Authors: Hidayati Devi Nisa , Jenie Riris Istighfari , Meiyanto Edy 
Published: February 2018

Curcuma (Curcuma xanthorriza Roxb.) and Awar-awar ((Ficus septica Burm.f.) are well known to have anticancer potential especially for breast cancer with low toxicity. This study aims to examine the potential effect of the combination of Curcuma ethanolic extracts (CEE) and awar-awar leaves ethanolic extract (AEE) to increase the efficacy of cisplatin toward T47D breast cancer cells. The combination activity was done using 3 series of concentration, 1/3; 1/6 and 1/12 of IC50, to determine the combination index (CI) of cisplatin, CEE and AEE under MTT assay. The result showed that the combination of 2.5 µM, 5 µg/ml, 1 µg/ml concentrations of cisplatin, CEE and AEE respectively result in synergistic effect with CI values less than 1. The treatment exhibited the cell accumulation in S phase (27.7%) against T47D breast cancer cells confirmed through cell cycle examination by flow cytometry. These results provided the evidence that the CEE and the AEE can be developed as co-chemotherapeutic agents combined with cisplatin to improve the effectiveness of breast cancer treatment.Keywords : Curcuma xanthorriza Roxb., Ficus septica Burm.f., cisplatin, cell cycle