bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbamazepine-induced Stevens-Johnson Syndrome: A Case Report with Review of the Literature
Authors: Subramanian Arunkumar , Haitharali Rajamohamed , S Nirenjen , T Tamilanban , Dhansekaran Sivaraman , Gnanasekaran Sabariakilesh , Manavalan Mohankumar , Raja Sangeetha 
Published: November 2024

Background:
Stevens-Johnson Syndrome (SJS) is an infrequent yet severe mucocutaneous
reaction that involves less than 10% of the Body Surface Area (BSA). It is predominantly
induced by certain medications, including anticonvulsants (e.g., Lamotrigine, Carbamazepine,
Phenytoin, Phenobarbitone), Allopurinol at doses above 100 mg per day, and sulphonamides
(e.g., Cotrimoxazole, Sulfasalazine). Genetic predispositions, particularly the presence of the
HLA-B*1502 allele, significantly increase the risk of developing SJS. This case report discusses
a unique presentation of SJS in a young female patient, emphasizing the critical need for genetic
screening and careful monitoring when prescribing Carbamazepine, especially in populations at
higher genetic risk.

Case Presentation:
A 19-year-old female patient, who had been on Phenytoin and Sodium
Valproate for epilepsy management over the past year, was newly prescribed Carbamazepine.
Within a week of initiating Carbamazepine, the patient experienced a seizure, followed by the
sudden onset of fever, painful sores, and blisters covering the upper body, along with mucous
discharge from both eyes. These symptoms rapidly worsened. Based on clinical presentations
and the extent of epidermal detachment, the patient was diagnosed with SJS. The severity and
mortality risks were assessed using the SCORTEN score. Therapeutic interventions included intravenous
Ranitidine, Ondansetron, Paracetamol, Midazolam, Levetiracetam, and Dexamethasone,
along with oral Fluconazole, Chlorpheniramine tablets, and Ciprofloxacin eye drops.
The patient showed significant improvement and was discharged after fourteen days with followup
advice.

Conclusion:
This case underscores the critical importance of performing genetic testing for the
HLA-B*1502 allele and conducting baseline blood tests before initiating Carbamazepine therapy.
Such precautionary measures can significantly mitigate the risk of severe adverse reactions
like SJS. This report adds to the scientific literature by highlighting the potential dangers associated
with anticonvulsant therapies and the necessity for personalized medicine approaches in
preventing life-threatening conditions. The main takeaway is the pivotal role of genetic screening
and vigilant monitoring in the management of patients requiring anticonvulsant medications to
prevent serious adverse reactions.
Composition and Biological Activity of Flavonoid-containing Fractions of an Extract
from Gratiola officinalis L.
Authors: Shirokov Alexander , Grinev Vyacheslav , Kanevskiy Matvey , Fedonenko Yulia , Matora Larisa , Polukonova Natalya , Mudrak Dmitry , Mylnikov Artyom , Polukonova Anna , Bucharskaya Alla , Navolokin Nikita , Maslyakova Galina 
Published: November 2024

Introduction:
Gratiola officinalis L. (hedge hyssop), a medicinal plant of the Scrophulariaceae family,
has diuretic, purgative, and vermifuge properties. It is used as a herbal tea to treat chronic gastroenteritis, renal
colic, jaundice, and intestinal worms. Previously, we have found that an extract from G. officinalis is nontoxic
and has antitumor, antioxidant, antimicrobial, antiinflammatory, anticachexic, and other properties. Our aims in
this study were to separate the G. officinalis extract into individual fractions, to identify the most biologically
active fractions, and to examine the chemical composition of these fractions and their biological activity toward
A498 renal carcinoma cells.

Methods:
The G. officinalis extract was fractionated by reversed-phase high-performance liquid chromatography,
and each fraction was tested for antitumor activity. The active fractions were characterized by UV-visible electron
spectral analysis, circular dichroism analysis, Fourier transform infrared spectroscopy, high-performance
liquid chromatography, electrospray ionization tandem mass spectrometry, and nuclear magnetic resonance spectroscopy.

Results:
Two antitumor-active fractions of a flavonoid nature were isolated and chromatographically purified. On
the basis of the nuclear magnetic resonance data, the aglycone fragment of the main component of one fraction
was found to be structured as 2-(3,4-dimethoxyphenyl)-7-hydroxychroman-4-one, or 3',4'-dimethoxy-7-
hydroxyflavanone.

Conclusion:
The antitumor effect of the most active fraction containing 7-O-glucoside of apigenin, glycoside
7,3'-di-O-luteolin and trace amounts of eupatilin against renal carcinoma A498 cells was manifested in its cytotoxic,
cytostatic, apoptotic and autophagosomal activities. In addition, we found 3-(1-2)-glucoside of
soyaspogenol B, which is a pentacyclic triterpenoid in the structure.
Cardio-metabolic Disorders Affected by Genetic Polymorphisms Related to Premature Menopause
Authors: Mirinezhad Mohammad Reza , Bana Hamideh Safarian , Aghsizadeh Maliheh , Mohammadi Mohammad Amin , Ghazizadeh Hamideh , Dabagh Ali Ebrahimi , Mir Nourbakhsh Sayyedeh Helya , Shahvandi Hassan Kiani , Ghodsi Alireza , Aghsizadeh Mahdie , Taghipour Faezeh , Hasanzadeh Elahe , Andalibi Nazanin Sheikh , Khedmatgozar Hamed , Ferns Gordon A. , Hamzehloei Tayebeh , Pasdar Alireza , Ghayour-Mobarhan Majid 
Published: November 2024

Background:
Premature menopause (PM) is defined as the end of ovulation before the
age of 40 years, a condition commonly referred to as primary ovarian insufficiency. It has been
shown there is an association between early menopause and a high risk of cardiovascular disease.

Aim:
This study aimed to evaluate the effect of genetic polymorphisms related to premature menopause
on cardio-metabolic disorders

Objective:
We aimed to investigate the single nucleotide polymorphisms associated with PM and
the risk of cardio-metabolic disorders in the MASHAD cohort study.

Methods:
In this cross-sectional study, a total of 117 women with PM were recruited and compared
with 183 healthy women. All participants were assessed for anthropometric indices and
genotyped for eight selected polymorphisms within seven different genes.

Results:
A significant difference was observed in physical activity level (PAL) between the
groups. Individuals with rs4806660 CC genotype had a 3.63-fold increased risk of metabolic syndrome.
Moreover, individuals with a TT genotype of the rs2303369 polymorphism had a 3.11--
fold increased risk of obesity.

Conclusion:
Our findings showed that genetic variations are risk factors related to cardio-
metabolic disorders in women with premature menopause.

other:
Cardio-metabolic disorders affected by genetic polymorphisms related to premature menopause
Recent Advancement in Pyrazole Derivatives as Antimalarial Agents and their SAR Study
Authors: Paliwal Deepika , Thakur Aman , Sahu Rakesh , Shah Kamal , Rao GSN Koteswara 
Published: November 2024

Abstract:
Malaria is caused by protozoan parasites and is a significant contributor to global
mortality and morbidity. The main reasons for the resurgence of malaria are the emergence of
drug-resistant strains of the parasite and the ineffectiveness of current treatment. Pyrazole-based
drugs play a crucial role in medicinal chemistry due to their diverse pharmacological properties.
The pyrazole structure, a five-membered ring with two nitrogen atoms, is a key pharmacophore
in various therapeutic agents. Numerous derivatives of pyrazole scaffold exhibited a wide range
of pharmacological activity such as analgesics, antiinflammatory, antioxidant, antimicrobial, antidiabetic,
anticancer, antiviral, antifungal, and antithrombotic activities. These drugs provide
numerous opportunities for enhancing antimalarial agents by targeting various critical receptors.
Various pyrazole derivatives have been reported to inhibit enzymes, receptors, and other targets
to manage malaria. These derivatives inhibited parasite through various mechanisms such as
falcipain, dihydrofolate redcutase, dihydroorotate dehydrogenase, lactate dehydrogenase, protein
kinase, calcium dependent protein kinase, glycogen synthase kinase, and histo aspartic protease.
Currently, researchers are developing new pyrazole-based derivatives, often in combination
with other moieties, for improved malaria treatment. This review highlights the recent therapeutic
advancements of pyrazole, including its structure-activity relationship, molecular docking,
commercial drug availability, and a summary of recent research publications, all of which
collectively assist scientists in developing effective drugs with desired pharmacological activities.
Synthesis, Characterization, and Anticancer, Antidiabetic, and Antimicrobial Activities of Azo-Schiff Base Ligand with ONO Donor Atom and its Transition Metal Complexes
Authors: Sakhare Kuldeep Bhaskar , Sakhare Mahadeo Abarao , Sarwade Kirti Navnath , Bharate Yogesh Navnath 
Published: November 2024

Introduction:
Cancer, diabetes, and infection of bacteria and fungi are serious issues
in the world. Synthesis of the potential drugs against them is a major challenge to the researcher.
Hence, coordination chemistry has attracted researchers as it has various applications
in medicinal and biological fields.

Methods:
Synthesis and biological evolution of azo-Schiff base ligand and its Mn(II), Co(II),
Ni(II), Cu(II), Zn(II), and VO(II) metal complexes were carried out. These compounds were
characterized by Mass, 1H-NMR, FT-IR, Elemental analysis, Molar conductance, Magnetic
susceptibility, UV-Vis., P-XRD, TGA, etc., and were screened for biological activities.

Result:
Synthesised azo-Schiff base ligand and its metal complexes were evaluated for their
antimicrobial, antidiabetic as well as anticáncer activities against various bacteria and fungi
and MCF-7 breast cancer cell line, respectively.

Conclusion:
From the findings of various results, we can conclude that the synthesized metal
complexes exhibit higher biological activities than the azo-Schiff base ligand.
Research on the Warm Mixing Effect and Evaluation Method of WMA-DSBS Modified Asphalt
Authors: Shi Silin , Wu Di , Yang Jixu , Yan Xiang , Zhang Wengang , Cui Lilong 
Published: November 2024

Background:
Traditional SBS-modified asphalt consumes a large amount
of energy during the production process. WMA-DSBS-modified asphalt can reduce
the mixing temperature, which is crucial for reducing energy consumption.

Objectives:
The aim of this study was to reduce the mixing temperature as much as
possible without compromising the performance of the asphalt mixture while saving
energy consumption and protecting the environment. By evaluating the warm mixing
effects of different warm mixing types applied to direct-to-plant SBS (DSBS) modified
asphalt, as well as the changes in road performance after warm mixing DSBS
modified asphalt mixture, reference opinions are provided for the dosage of warm
mixing agents in engineering problems.

Method:
A comparison is made between DSBS-modified asphalt and warm mix
DSBS-modified asphalt in terms of technical performance parameters. On the basis of
the Brinell rotational viscosity test and the variable temperature compaction test, an
index system for evaluating the modification effect of warm-mixed asphalt was developed.

Result:
The research results indicated that three different warm mixing agents have
an enhancing effect on the temperature sensitivity, high-temperature performance,
and low-temperature plastic deformation ability of asphalt in some temperature ranges.
The viscosity of DSBS modified asphalt decreases with the increase of temperature
before and after the addition of the three warm mix agents. During the temperature
increase process, the viscosity reduction index K value changes from negative to
positive; The dosage of warm mixing agent is negatively correlated with the porosity
of WMA-DSBS modified asphalt mixture, and as the temperature increases, the porosity
of the mixture will decrease. The performance value T shows an upward trend,
improving its road performance.

Conclusion:
A reasonable dosage of warm mix agent can significantly reduce the
mixing temperature, therefore WMA-DSBS modified asphalt plays an important role
in reducing energy consumption.
PENGEMBANGAN GAME EDUKASI BERBASIS APLIKASI ANDROID UNTUK MELATIH LITERASI DIGITAL DAN KETERAMPILAN ARGUMENTASI ILMIAH SISWA KELAS X SMA PADA MATERI VIRUS DAN PERANANNYA
Authors: Putri Nada Oktavia , Akmalia Hafidha Asni , Tauhidah Dian 
Published: November 2024

Keterampilan abad 21 melalui pendidikan holistik menjadi suatu hal penting yang tidak dapat diabaikan, terutama seiring dengan perkembangan era digital yang mengubah paradigma pembelajaran di mana kebutuhan akan keterampilan seperti literasi digital, pemecahan masalah, kreativitas, dan kolaborasi semakin mendesak serta tidak hanya mengandalkan pengetahuan tetapi keterampilan ikut berperan dalam pembelajaran abad 21. Penelitian ini bertujuan untuk mengembangkan, menganalisis kelayakan, dan keterbacaan dari produk game edukasi berbasis aplikasi android untuk melatih literasi digital dan keterampilan argumentasi ilmiah siswa kelas X SMA pada materi virus dan peranannya. Jenis penelitian yang digunakan pada penelitian ini adalah penelitian pengembangan (Research and Development) dengan model pengembangan 4-D yang mencakup tahapan yaitu Define (Pendefinisian), Design (Perancangan), dan dibatasi pada Develop (Pengembangan). Hasil dari produk yang dikembangkan berupa game edukasi berbasis aplikasi android. Berdasarkan hasil uji validasi, diperoleh nilai kelayakan sebesar 77,03% dari ahli media, 89,5% dari ahli materi, 82,5% dari ahli literasi digital, 86,66% dari ahli argumentasi ilmiah, dan 87,93% dari respon guru Biologi. Uji keterbacaan dari respon siswa dengan uji skala kecil sebesar 83,46% dari hasil uji skala kecil. Berdasarkan perolehan hasil uji dapat disimpulkan bahwa, media game edukasi berbasis aplikasi android untuk melatih literasi digital dan keterampilan argumentasi ilmiah siswa kelas X SMA pada materi virus dan peranannya dikategorikan sangat layak dan valid untuk digunakan.
Exploring the Use of Activity Trackers to Support Physical Activity and Reduce Sedentary Behavior in Adults Diagnosed With Type 2 Diabetes: Qualitative Interview Study Using the RE-AIM Framework
Authors: Hodgson William , Kirk Alison , Lennon Marilyn , Janssen Xanne 
Published: November 2024

Abstract

Background
The prevalence of type 2 diabetes in adults worldwide is increasing. Low levels of physical activity and sedentary behavior are major risk factors for developing the disease. Physical activity interventions incorporating activity trackers can reduce blood glucose levels in adults diagnosed with type 2 diabetes. The My Diabetes My Way website is a support and educational platform for people diagnosed with diabetes and health care professionals. Users of the My Diabetes My Way website can upload their Fitbit (Google Inc) activity data into the system but this is not presently being analyzed and used routinely within clinical care. Developers of the My Diabetes My Way system are planning to allow different makes of activity trackers to be integrated with the platform.

Objective
This qualitative study aimed to explore (through the RE-AIM [reach, effectiveness, adoption, implementation, and maintenance] framework) views from adults diagnosed with type 2 diabetes and health care professionals on the integration of activity trackers into type 2 diabetes care.

Methods
Overall, 12 adults diagnosed with type 2 diabetes and 9 health care professionals (4 general practitioners, 1 consultant, 2 diabetes nurses, 1 practice nurse, and 1 physical activity advisor) were recruited through social media and professional contacts. Semistructured one-to-one interviews were conducted. Abductive thematic analysis was undertaken, and main themes and subthemes were identified. The RE-AIM framework was used to evaluate the themes with respect to the wider use of activity trackers and the My Diabetes My Way platform within type 2 diabetes clinical care.

Results
Overall, 6 main themes (awareness, access, cost, promotion, support, and technology and data) and 20 subthemes were identified. Evaluation using the 5 RE-AIM dimensions found that reach could be improved by raising awareness of the My Diabetes My Way platform and the ability to upload activity tracker data into the system. Effectiveness could be improved by implementing appropriate personalized measures of health benefits and providing appropriate support for patients and health care staff. Adoption could be improved by better promotion of the intervention among stakeholders and the development of joint procedures. Implementation could be improved through the development of an agreed protocol, staff training, and introducing measurements of costs. Maintenance could be improved by supporting all patients for long-term engagement and measuring improvements to patients’ health.

Conclusions
Through this study, we identified how the reach, effectiveness, adoption, implementation, and maintenance of integrating activity trackers into adult type 2 diabetes care could be improved.
Building a Human Digital Twin (HDTwin) Using Large Language Models for Cognitive Diagnosis: Algorithm Development and Validation
Authors: Sprint Gina , Schmitter-Edgecombe Maureen , Cook Diane 
Published: November 2024

Background
Human digital twins have the potential to change the practice of personalizing cognitive health diagnosis because these systems can integrate multiple sources of health information and influence into a unified model. Cognitive health is multifaceted, yet researchers and clinical professionals struggle to align diverse sources of information into a single model.

Objective
This study aims to introduce a method called HDTwin, for unifying heterogeneous data using large language models. HDTwin is designed to predict cognitive diagnoses and offer explanations for its inferences.

Methods
HDTwin integrates cognitive health data from multiple sources, including demographic, behavioral, ecological momentary assessment, n-back test, speech, and baseline experimenter testing session markers. Data are converted into text prompts for a large language model. The system then combines these inputs with relevant external knowledge from scientific literature to construct a predictive model. The model’s performance is validated using data from 3 studies involving 124 participants, comparing its diagnostic accuracy with baseline machine learning classifiers.

Results
HDTwin achieves a peak accuracy of 0.81 based on the automated selection of markers, significantly outperforming baseline classifiers. On average, HDTwin yielded accuracy=0.77, precision=0.88, recall=0.63, and Matthews correlation coefficient=0.57. In comparison, the baseline classifiers yielded average accuracy=0.65, precision=0.86, recall=0.35, and Matthews correlation coefficient=0.36. The experiments also reveal that HDTwin yields superior predictive accuracy when information sources are fused compared to single sources. HDTwin’s chatbot interface provides interactive dialogues, aiding in diagnosis interpretation and allowing further exploration of patient data.

Conclusions
HDTwin integrates diverse cognitive health data, enhancing the accuracy and explainability of cognitive diagnoses. This approach outperforms traditional models and provides an interface for navigating patient information. The approach shows promise for improving early detection and intervention strategies in cognitive health.
Research on the Academic Growth and Engineering Ability Cultivation of Students in Private Universities Based on the Concept of “CDIO-F”
Authors: Yang Yufan 
Published: November 2024

The CDIO concept is an advanced engineering education concept. Private universities are an important component of higher education in China, and academic growth and engineering ability are key indicators for cultivating engineering college students. However, in private universities, the academic growth and engineering ability cultivation of engineering students cannot fully meet the needs of society. Therefore, the cultivation of students’ academic growth and engineering ability has become an urgent issue to be solved. On the basis of the CDIO concept, the paper adds a feedback link and proposes a CDIO-F engineering education model. By demonstrating the compatibility of the CDIO-F concept with students’ academic growth and engineering ability cultivation, a CDIO-F based model for private university students’ academic growth and engineering ability cultivation is established. This provides new ideas for the cultivation of engineering majors in private universities.
Exploring the Fullness of Grace: Wesleyan Moves from Charity, Service, and Advocacy to Deep Solidarity
Authors: Rieger Joerg 
Published: November 2024

Abstract
This article deepens the Wesleyan understanding of works of mercy as means of grace, arguing that the fullness of a Wesleyan theology of grace can only be explored when we extend the church’s imagination beyond the current ecclesial practices of charity, service, and advocacy. More profound encounters of divine grace are emerging when works of mercy are interpreted in terms of what will be called “works of deep solidarity.” Engaging in deep solidarity with others and with God, in places where we least expect it and cannot yet fully envision it, has the potential of sparking the next revival.
Exploring the ESKAPE maze: Pneumonias, resistance and therapeutic perspectives
Authors: Stoian Ioana Adelina , Antal Andreea Zabară , Antohi Paula Vasilache , Țău Victoria , Pintilie Adriana Loredana , Trofor Antigona Carmen , Crișan-Dabija Radu Adrian 
Published: November 2024

Abstract
The article explores drug-resistant bacteria within the ESKAPE group, commonly associated with nosocomial infections, focusing on the resistance mechanisms of Acinetobacter baumannii and Klebsiella pneumoniae. The study delves into various β-lactamase enzymes and resistance mechanisms exhibited by ESKAPE bacteria, shedding light on the challenges posed by carbapenem-resistant infections. Notably, the article underscores the ongoing need for research to develop more effective treatments and address the persistent challenges associated with drug resistance in the context of nosocomial infections. The examination of this subset of bacteria aims to contribute to a comprehensive understanding of their resistance mechanisms and provides insights into the difficulties encountered in treating infections with carbapenem-resistant pathogens. The article serves as a valuable resource for clinicians, researchers and policymakers, offering a detailed perspective on the current state of drug resistance among nosocomial pathogens and advocating for continuous research to enhance treatment efficacy in the face of evolving challenges.