bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le SK-8, comme symptôme d’un adolescent : regard psychanalytique et perspectives en EPS
Authors: Montagne Yves-Félix 
Published: August 2019

Ce travail se propose de montrer en quoi le SK8 (sk-eight = skate board) est la solution choisie par un sujet pour affronter le nouveau inquiétant qui peut surgir chez l’être humain à l’adolescence. Le champ conceptuel et méthodologique de la psychanalyse permettra une construction de cas. L’analyse interprétative des dires d’Eddie, un adolescent de 14 ans, permettra de poser en quoi le SK8 est sa réponse dans le Réel aux questions essentielles que l’être humain se pose à cette période de sa vie : « Qui suis-je ? », « Qu’est-ce que la mort ? », « Qu’est-ce que le sexe ? » Fort de ces éclairages, des perspectives d’education physique et sportive intégrant cet usage signifiant d’une activité physique sportive et artistique seront présentées.
Des expert·e·s respectables ? Esthétique vestimentaire et production de la confiance
Authors: Boni-Le Goff Isabel 
Published: August 2019

Considéré comme « intellectuel », le conseil en management est rarement envisagé sous l’angle des médiations corporelles, ni du travail d’incarnation qu’il implique. Dès l’entrée dans le métier, les consultant·e·s débutant·e·s apprennent pourtant à tenir compte d’un ensemble d’attentes historiquement et socialement construites, à produire une façade personnelle convaincante et à réaliser un passing expert. La production contrôlée de cette figure d’expert met en jeu de façon centrale le vêtement. L’article souligne combien les normes vestimentaires contemporaines de la profession sont marquées par les figures professionnelles construites historiquement et témoignent de la persistance d’une esthétique genrée, en dépit de l’entrée importante de femmes dans cet ancien bastion masculin. Puis il analyse les expériences vestimentaires complexes des femmes consultantes : la vigilance permanente portée par celles-ci au risque de fausse note vestimentaire, la peur très partagée de commettre une erreur esthétique et symbolique. En s’intéressant aux situations vestimentaires problématiques, l’article offre un éclairage heuristique sur les fonctions sociales et symboliques du vêtement professionnel, sur la violence symbolique ainsi que les rapports de pouvoir dont il peut être le support.
Les chaînes de référence dans les textes encyclopédiques du 12 e au 21 e siècle : étude longitudinale
Authors: Oberlé Bruno , Schnedecker Catherine , Baumer Emmanuel , Capin Daniéla , Glikman Julie , Guo Chang , Revol Thierry , Todirascu Amalia , Tushkova Julia 
Published: August 2019

Cette étude originale vise à dégager l’évolution diachronique dans la composition des chaînes de référence sur une diachronie très large, couvrant des textes à caractère encyclopédique allant du 12 e au 21 e siècle et portant sur des référents de même type (des animaux). L’objectif est de faire ressortir l’impact des facteurs censés influencer les chaînes de référence : leur genre discursif d’occurrence et l’époque de leur composition. L’étude s’appuie sur un corpus annoté en références et coréférences de 13 623 mots (4 418 expressions référentielles), dont tous les référents ont été annotés.
BST2 promotes growth and induces gefitinib resistance in oral squamous cell carcinoma via regulating the EGFR pathway
Authors: Jin Huang , Zhang Lianping , Wang Shufang , Qian Lei 
Published: August 2019

IntroductionGefitinib, well known as a new antitumor agent, has been applied in various cancers such as oral squamous cell carcinoma (OSCC). However, most patients eventually acquire resistance to gefitinib, and the molecular mechanism of gefitinib resistance is not well described. Bone marrow stromal cell antigen 2 (BST2) has been reported to promote tumor cell growth and confer chemotherapy resistance in various cancers. However, the roles of BST2 in OSCC still need to be fully understood.Material and methodsWe determined the expression of BST2 in OSCC tissues using qRT-PCR, immunohistochemistry and western blot. Next, we used MTT assay, flow cytometry and western blot to determine the roles of BST2 in OSCC cell proliferation, cycle progression and apoptosis, respectively. Furthermore, we evaluated the effect of BST2 on gefitinib resistance in OSCC cells and explored the related molecular mechanism.ResultsBST2 expression was up-regulated in OSCC tissues compared with the adjacent normal tissues. BST2 overexpression significantly enhanced OSCC cell proliferation, mediated the cell cycle progression and inhibited cell apoptosis. Additionally, the results showed that BST2 overexpression effectively induced gefitinib resistance in OSCC cells. Subsequent analysis revealed that the underlying mechanism was associated with activation of the EGFR pathway.ConclusionsOur study indicated that BST2 promoted growth and induced gefitinib resistance in OSCC cells, at least partially, through regulating the EGFR pathway. Thus, BST2 could be used as a therapeutic target for gefitinib resistance in OSCC.
Hypothermia enhances heme oxygenase 1-expressing mesenchymal stem cell-induced repair of cerebral hypoxia-ischemia
Authors: Yan Xuetao , Cheng Xiao-Li , He Xiang-Hu , Zheng Wen-Zhong , Yuan Xiao-Fang , Chen Hu 
Published: August 2019

IntroductionMesenchymal stem cells (MSC) are known to exhibit potency for the repair of cerebral hypoxia-ischemia (HI). Heme oxygenase 1 (HO-1) is capable of inducing repair and can boost stem cell-based therapeutic effects. Hypothermia is known to have strong cytoprotective effects.Material and methodsHO-1 secreting lentiviral vector was constructed and transfected into MSC. HO-1 secretion from HO-1/MSC was verified using Western blot, real-time PCR and ELISA tests. The proliferation and anti-oxidative abilities of HO-1/MSC were detected by CCK-8 assay and biochemical kits. The therapeutic efficacy of HO-1/MSC in a rat cerebral HI model under normothermia or hypothermia was then tested. The cells were transplanted into HI animal models and the rats were kept at 37°C or 25°C. The histological pathology, apoptosis and behavior were analyzed with Nissl stain, TUNEL analysis, and rotarod and cylinder tests respectively. MSC survival and differentiation in vivo were also analyzed by immunofluorescence.ResultsHO-1 secretions promoted the proliferation and anti-oxidative abilities of MSC. The HO-1/MSC significantly improved the apoptosis, injury, behavior and enhanced MSC survival and differentiation into mature neurons and oligodendrocytes. Moreover, HO-1/MSC significantly enhanced repair of HI under hypothermia.ConclusionsThese results suggest that HO-1-secreting MSC under hypothermia is an effective therapeutic approach for the treatment of HI.
Prevalence of sexual dysfunctions and associated risk factors in Poland
Authors: Lew-Starowicz Zbigniew , Czajkowska Kamila 
Published: August 2019

IntroductionMany biological, psychological and sociocultural factors influence the prevalence of sexual dysfunctions and sexual behavior. The purpose of the study was to evaluate the prevalence of sexual dysfunctions and sexual behaviors.Material and methodsThe study was the third edition of a general population-based, cross sectional survey, evaluating sexual attitude, sexual behaviors within and outside relationships and type of sexual dysfunctions present in the Polish population. The survey consisted of 82 questions, grouped into five blocks that contained open- and closed-ended general questions, inquiries about early sexual contacts, sex life, relationships, sexual behaviors and preferences. A standard questionnaire was used to obtain data on age, education, marital status, religious beliefs, medical history, disabilities and other illnesses. A total of 1054 responders aged from 18 to over 70 years participated in the study. Risk factors and other causes contributing to certain sexual dysfunctions defined in the DSM-5 and in the available literature were analyzed.ResultsIn this research, 40% of women and 36.5% of men had at least one sexual dysfunction. Analysis of the total population showed that decreased sexual desire (29.0%), occasional climaxing (28.5%) and anorgasmia (21.0%) were the dysfunctions most frequently reported by women. In men, premature ejaculation (23%) and excessive sexual needs (16.3%) were most prevalent. Both men and women with arousal problems reported significantly more comorbid sexual dysfunctions (p < 0.001).ConclusionsSexual dysfunctions are highly prevalent in the Polish population. Of note, it is alarming that only very few patients seek professional help when sexual problems occur.
The direct effect of lipopolysaccharide on an isolated heart is different from the effect on cardiac myocytes in vitro
Authors: Kuo Feng Yu , Lee Shu Ping , Cheng Juei-Tang , Wu Ming Chang 
Published: August 2019

IntroductionLipopolysaccharide (LPS) is widely used to induce experimental animals. However, its effects on cardiac contraction is controversial. Although LPS probably induces its influence in vivo both directly and indirectly, we focused on the direct effects of LPS in this report.Material and methodsIsolated ventricular myocytes mounted on a Langendorff apparatus were perfused with LPS. The changes in cultured H9c2 cells incubated with LPS over a 3-h exposure were compared with the changes after a 24-h incubation. Apoptosis was identified using flow cytometry and Western blotting. The mRNA levels were also determined.ResultsLPS directly stimulated cardiac contractility at low doses, although it produced inhibition at higher doses. The TLR4-coupled JAK2/STAT3 pathway was identified in H9c2 cells after LPS treatment, with an increase in intracellular calcium levels. LPS dose-dependently activated hypertrophic signals in H9c2 cells and induced apoptosis at the high dose. However, apoptosis was observed in H9c2 cells after a 24-h exposure to LPS, even at low doses. This observation appears to be associated with the level of paracrine cytokines. Changes in H9c2 cells by LPS were diminished by NPS2390, an inhibitor of the calcium-sensing receptor (CaSR). LPS also promoted CaSR mRNA expression in H9c2 cells, which may be unrelated to the changes in cytokine expression influenced by an inflammasome inhibitor.ConclusionsIn contrast to the isolated hearts, LPS activated hypertrophic signals prior to apoptotic signals in cardiac cells. Thus, LPS injury appears to be associated with CaSR, which was not markedly influenced by an inflammasome inhibitor.
Long non-coding RNA OIP5-AS1 promotes cell proliferation and aerobic glycolysis in gastric cancer through sponging miR-186
Authors: Huang Jiaobao , Hou Shuangshuang , Xu Jian , Wu Ju , Yin Jiajun 
Published: August 2019

IntroductionLong non-coding RNAs (lncRNAs) play vital roles in tumour initiation and progression. LncRNA OIP5-AS1 is a potential oncogene in many types of human malignancies, but its biological functions in gastric cancer (GC) remain to be further elucidated.Material and methodsThe expression levels of OIP5-AS1 and miR-186 in GC tissues and cell lines were detected by RT-qPCR analysis. CCK-8 assay and colony formation assay were performed to investigate the proliferation of GC cells in vitro, and a nude mouse tumour model was established to validate the role of OIP5-AS1 in GC tumorigenesis in vivo. The glucose consumption and lactate production of GC cells were detected by ELISA assay. Interaction between OIP5-AS1 and miR-186 was determined using dual luciferase reporter assay.ResultsThe results demonstrated that OIP5-AS1 was upregulated in GC tissues and cell lines and that its high expression was notably correlated with aggressive clinicopathological features of GC patients. Functionally, knockdown of OIP5-AS1 inhibited GC cell proliferation and enhanced cell apoptosis in vitro, and inhibited GC xenograft growth in vivo. In addition, knockdown of OIP5-AS1 reduced the glucose consumption and lactate production in GC cells. In particular, OIP5-AS1 may function as a ceRNA for miR-186, and inhibition of miR-186 blocks the effects of OIP5-AS1 knockdown on aerobic glycolysis in GC cells.ConclusionsAccordingly, our findings suggested that the OIP5-AS1/miR-186 axis might be considered as a potential therapeutic target for GC patients.
Runx1 promotes the development of glioma cells
by regulating JAK-STAT signalling pathway
Authors: Zhang Yong , Xia Qiming , Lin Jun 
Published: August 2019

IntroductionHuman glioma is known as the most frequent and primary malignant tumour of the central nervous system with high aggression and poor prognosis. Runx1 is essential for haematopoiesis and is associated with tumour progression in several types of cancers. Therefore, this study aimed to investigate the effect and the possible regulatory mechanisms of Runx1 in glioma.Material and methodsThe expression of Runx1 in human glioma tissues was determined by qRT-PCR and immunohistochemistry (IHC). Subsequently, the effect of Runx1 on the glioma cell viability, migration, invasion and the protein level of p21, cyclin D1, MMP2, and MMP4 were detected by MTT, wound healing, transwell assays, and western blot, respectively, in U-138MG and U-251MG cell lines. We then explored the role of Runx1 in vivo by establishing a tumour-bearing mouse model.ResultsThe expression of Runx1 was significantly up-regulated in human glioma tissues and closely associated with tumour grade. Glioma patients with high Runx1 expression had decreased survival rate compared to those with low Runx1 level. Runx1 knockdown inhibited glioma cell viability, migration, invasion, and clone formation, while STAT3 suppressed these inhibitions. Moreover, Runx1 inhibited the activation of SOCS3/SOCS4 promoter, which in turn activated JAK/STAT3 signalling pathway. The tumour volume and weight of the siRunx1 group were lower than in the control group and the tumour mass grow more slowly as well.ConclusionsRunx1 promotes the development of glioma cells via JAK/STAT signalling pathway by inhibiting the activation of SOCS3/SOCS4 promoter.
If something looks like an apple, is it necessarily an apple?
Some considerations about so-called “statin-induced polymyalgia rheumatica”
Authors: Manzo Ciro 
Published: August 2019

The existence of polymyalgia rheumatica (PMR) induced by statins has been hypothesised by some investigators. This review article highlights the fact that there is no evidence it is real. On the contrary, PMR and statin-associated muscle symptoms (SAMS) are two totally different conditions. Shoulder and hip ultrasound (US) examinations can make an important contribution in distinguishing a true case of PMR from a PMR-like illness induced by statins. The possibility that SAMS may worsen the clinical manifestations of a PMR patient should be taken into account in clinical practice, and drug discontinuation should be proposed when deterioration or relapse is not otherwise justifiable.
Mixed-etiology leg ulcers in a patient on long-term glucocorticoid therapy
Authors: Sławiński Piotr , Radkowski Marcin , Lewandowicz Andrzej , Targowski Tomasz 
Published: August 2019

Chronic leg ulceration is a frequent condition in elderly patients. Chronic wounds that are nonresponsive to 3-month therapy affect approximately 6.5 million people in the United States with a prevalence of 1% and costs estimated at 25 billion dollars per year. Although the main causes are venous insufficiency, lower extremity arterial disease and diabetes, in many cases the etiology is multi-factorial. Approximately 20–23% of non-healing wounds that are refractory to vascular intervention have other etiologies including vasculitis, rheumatoid arthritis and Sjögren syndrome. Adverse drug interactions are the least commonly considered, especially those which involve disease-modifying anti-rheumatic drugs.<br />
The authors present a report on a female patient with reported Sjögren syndrome, multiple morbidities and non-healing lower limb ulceration that developed during treatment with methotrexate, and no significant improvement after discontinuation of the drug and after vascular surgery. Microvascular deterioration caused by beta-blockers was considered decisive. Calcium-blocker replacement brought complete healing in the follow-up.
On the resolutions of ocean altimetry maps
Authors: Ballarotta Maxime , Ubelmann Clément , Pujol Marie-Isabelle , Taburet Guillaume , Fournier Florent , Legeais Jean-François , Faugère Yannice , Delepoulle Antoine , Chelton Dudley , Dibarboure Gérald , Picot Nicolas 
Published: August 2019

Abstract. The Data Unification and Altimeter Combination System (DUACS) produces sea level global and regional
maps that serve oceanographic applications, climate forecasting centers,
and geophysics and biology communities. These maps are generated using an
optimal interpolation method applied to altimeter observations. They are
provided on a global 1∕4∘ × 1∕4∘ (longitude × latitude) and daily grid resolution framework
(1∕8∘ × 1∕8∘ longitude × latitude grid for the regional products) through the Copernicus Marine Environment Monitoring Service (CMEMS). Yet, the dynamical content of these maps does not have full 1∕4∘ spatial and 1 d temporal resolutions due to the
filtering properties of the optimal interpolation. In the present study, we
estimate the effective spatial and temporal resolutions of the newly
reprocessed delayed-time DUACS maps (a.k.a. DUACS-DT2018). Our approach is
based on the ratio between the spectral content of the mapping error and the
spectral content of independent true signals (along-track and tide gauge
observations), also known as the noise-to-signal ratio. We found that the
spatial resolution of the DUACS-DT2018 global maps based on sampling by
three altimeters simultaneously ranges from ∼100 km wavelength
at high latitude to ∼800 km wavelength in the equatorial band
and the mean temporal resolution is ∼34 d. The mean
effective spatial resolution at midlatitude is estimated to be ∼200 km. The mean effective spatial resolution is ∼130 km for
the regional Mediterranean Sea and for the regional Black Sea products. An
intercomparison with previous DUACS reprocessing systems (a.k.a., DUACS-DT2010
and DUACS-DT2014) highlights the progress of the system over the past 8 years, in particular a gain of resolution in highly turbulent regions. The same diagnostic applied to maps constructed with two altimeters and maps with three altimeters confirms a modest increase in resolving capabilities and accuracies in the DUACS maps with the number of missions.
Análisis del desarrollo humanista en San Sebastián de Yalí, con énfasis en el caso de los cortadores de café 2018.
Authors: Martínez Rodríguez Yeimi Yunieth 
Published: August 2019

El tema y objetivo principal se centran en el análisis del desarrollo humanista en San Sebastián de Yalí, con énfasis en el caso de los cortadores de café. La metodología desarrollada tiene un enfoque meramente cualitativo, se hizo uso de dos métodos de recopilación de la información, el método etnográfico, fundamental en investigaciones de carácter antropológico, y el método de revisión bibliográfica, las técnicas que sirvieron de apoyo a los métodos fueron observación directa y entrevista semiestructurada, para el primero mencionado, y, arqueo bibliográfico para el segundo, en el procesamiento de datos se aplicó la técnica de análisis de datos. San Sebastián de Yalí basa su principal actividad económica en el modelo agro exportador, el sistema imperante que ha estado vigente desde décadas atrás, ha sumergido el país en una dependencia económica, que generó una agudización en las desigualdades, resultando contradictorio que este municipio a pesar de aportar a la generación de divisas, se encuentra entre los quinces municipios más pobres; en la última década con el cambio de gobierno y la implementación de programas que apuntan a una nueva lógica de desarrollo, se han logrado avances significativos en materia de educación y salud, sin embargo, no es de negar que en materia económica, producto a un sistema económico heredado que para un cambio profundo amerita cambios estructurales, el desarrollo humano integral se ha visto limitado. En conclusión el desarrollo económico propuesto por el sistema capitalista a pesar de mostrarse como una receta de solución a los problemas, ha tenido un efecto contrario frente a las problemáticas sociales, por tanto se puede considerar como un sistema anti-humanista el cual profundiza la brecha en desigualdad social, empujando a la continuidad de patrones culturales.
Det digitale bibliotek. Vilkår og visioner
Authors: Von Hjelmcrone Harald 
Published: August 2019

Forskningsbibliotekernes fremtid over de næste 20 år sammenlignes med udviklingen på tv-området: Til trods for et ønske om pluralitet har vi fået et stadig mere ensartet udbud af udsendelser. Dette skyldes organiseringen af markedet for fjernsynsprogrammer. En lignende organisationsform er ved at vinde indpas på markedet for biblioteksrelevante materialer. Giver bibliotekerne sig tilfreds med det, vil der ikke være behov for andet end en stor bevilling til licenser, et godt bogholderi og et edb-kontor, der kan administrere adgangsforholdene – ligesom kabelselskaberne nu gør det på radio- tv-området. Den retlige regulering af området, herunder især ophavsretten og persondataretten, vil gøre det vanskeligt for bibliotekerne at gå på tværs af markedet og fortsat stille et alsidigt og kvalitetspræget udbud af information til rådighed for brugerne. Skal tendenserne til ensretning modvirkes, kræver det en aktiv indsats, og den forudsætter at bibliotekernes personale har faglige kompetencer i de fag, biblioteket skal formidle, samt viden om medie- og informationsret. Denne artikel blev oprindelig holdt som oplæg til temadag om ”Visioner for forskningsbibliotekernes fremtid” på Danmarks Biblioteksskole den 2. april 2009.
Informationskompetence : Set ud fra to forskellige praksisteorier
Authors: Schreiber Trine 
Published: August 2019

I de senere år er praksisteorier blevet anvendt indenfor undersøgelser og analyser af informationskompetence. Teorierne er dog indbyrdes forskellige og vil derfor have forskellige implikationer for analyser af informationskompetence. Det er artiklens formål at sammenligne to praksisteorier, nemlig Theodore Schatzki ́s og Etienne Wenger ́s teorier med hensyn til hvad de indebærer for et emne som informationskompetence. De to tilgange har en del fælles træk men har også mange forskelle. Artiklen konkluderer at Schatzki ́s tilgang indebærer at man kan tale om såvel en informationspraksis som en informationskompetencepraksis. Kompetence og dermed informationskompetence kan ikke betragtes isoleret, men skal ses i sammenhæng med øvrige elementer i definitionen af en social praksis. Denne praksis indgår samtidig i et net af mange praksisser. Et centralt tema inden for emnet informationskompetence kan derfor være hvordan en informationspraksis kan opretholdes eller transformeres gennem netop dens sammenkædning med andre praksisser. Wenger ́s tilgang betyder derimod at man kan tale om et praksisfællesskabs kompetencesystem. På baggrund af en meningsforhandling udvikler praksisfællesskabet sitkompetencesystem og herunder dets informationskompetencesystem. Dette kan dog i f.eks. en organisation udfordres af andre værdier og dermed få vanskeligt ved at blive anerkendt som kompetencer.Et centralt tema inden for emnet informationskompetence kan derfor være den forskellighed og eventuelle konflikt, der kan være mellem praksisfællesskabets læreprocesser og kompetencesystem og de kravsom f.eks. den omkringliggende organisation opstiller. Artiklen konkluderer at det for begge teorier er vanskeligt at planlægge en ændring i en informationspraksis eller i et informationskompetencesystem. Forandringer er nemlig konstitueret af enten netværket af praksisser eller af praksisfællesskabets meningsforhandlinger.