bluuebunny/crossref_metadata_2025_split huggingface dataset:
PARTISIPASI SUAMI MELAKUKAN VASEKTOMI
Authors: Latifa Siti , Syafei Ermi Suhasti 
Published: May 2019

Family Planning Program is handled by the National Population and Family Planning Board (BKKBN), is a form of human endeavor in order to address the population problem by controlling the population with the goal of achieving a prosperous and happy families. In Indonesia, a vasectomy is a contraceptive in the national family planning program, and considered the only way of the family planning for men who are the most secure, reliable and does not cost a lot to swallow. Vasectomy is a method of family planning for men through a small operation with a knife or surgery without a knife to cut and tie the two lines so that the sperm at the time of intercourse, sperm can not fertilize an egg out the wife so that is not the case of pregnancy. It is clear that a vasectomy is different from other birth control methods, which are usually temporary, can be terminated at any time, here vasectomy is more permanent. This article examines participation of husbands in family planning in the perspective of Islamic.[Program Keluarga Berencana yang ditangani oleh Badan Kependudukan dan Keluarga Berencana Nasional (BKKBN) merupakan bentuk usaha manusia dalam rangka mengatasi masalah kependudukan melalui pengendalian penduduk dengan tujuan mewujudkan keluarga yang sejahtera dan bahagia. Di Indonesia, vasektomi merupakan salah satu kontrasepsi dalam program KB Nasional, dianggap satu-satunya cara ber-KB bagi pria yang paling aman, dapat dipercaya dan tidak menelan banyak biaya. Vasektomi merupakan cara ber-KB bagi pria melalui operasi kecil dengan menggunakan pisau operasi atau tanpa pisau untuk memotong dan mengikat kedua saluran sel mani sehingga pada waktu senggama, sperma tidak dapat keluar membuahi sel telur istri sehingga tidak terjadi kehamilan. Jelaslah bahwa vasektomi berbeda dengan metode-metode kontrasepsi lainnya, yang pada umumnya bersifat sementara, sewaktu-waktu dapat dihentikan, di sini vasektomi lebih bersifat permanen. Tulisan ini mengkaji peran serta suami melakukan vasektomi ditinjau dari hukum Islam.]
Global Components of Positive Bounded Variation Solutions of a One-Dimensional Indefinite Quasilinear Neumann Problem
Authors: López-Gómez Julian , Omari Pierpaolo 
Published: May 2019

AbstractThis paper investigates the topological structure of the set of the positive solutions of the one-dimensional quasilinear indefinite Neumann problem{-(u′1+u′2)′=λ⁢a⁢(x)⁢f⁢(u) in ⁢(0,1),u′⁢(0)=0,u′⁢(1)=0,\begin{dcases}-\Bigg{(}\frac{u^{\prime}}{\sqrt{1+{u^{\prime}}^{2}}}\Bigg{)}^{% \prime}=\lambda a(x)f(u)\quad\text{in }(0,1),\\ u^{\prime}(0)=0,\quad u^{\prime}(1)=0,\end{dcases}whereλ∈ℝ{\lambda\in\mathbb{R}}is a parameter,a∈L∞⁢(0,1){a\in L^{\infty}(0,1)}changes sign, andf∈C1⁢(ℝ){f\in C^{1}(\mathbb{R})}is positive in(0,+∞){(0,+\infty)}. The attention is focused on the casef⁢(0)=0{f(0)=0}andf′⁢(0)=1{f^{\prime}(0)=1}, where we can prove, likely for the first time in the literature, a bifurcation result for this problem in the space of bounded variation functions. Namely, the existence of global connected components of the set of the positive solutions, emanating from the line of the trivial solutions at the two principal eigenvalues of the linearized problem around 0, is established. The solutions in these components are regular, as long as they are small, while they may develop jump singularities at the nodes of the weight functiona, as they become larger, thus showing the possible coexistence along the same component of regular and singular solutions.
Inequalities for nonuniform wavelet frames
Authors: Shah Firdous A. 
Published: May 2019

Abstract
Gabardo and Nashed studied nonuniform wavelets by using the theory of spectral pairs for which the translation set

Λ
=

{
0
,

r
/
N

}

+

2
⁢
ℤ

{\Lambda=\{0,r/N\}+2\mathbb{Z}}

is no longer a discrete subgroup of

ℝ

{\mathbb{R}}

but a spectrum associated with a certain one-dimensional spectral pair.
In this paper, we establish three sufficient conditions for the nonuniform wavelet system

{

ψ

j
,
λ

⁢

(
x
)

=

(

2
⁢
N

)

j
/
2

⁢
ψ
⁢

(

(

2
⁢
N

)

j

⁢
x

-
λ

)

,

j
∈
ℤ

,

λ
∈
Λ

}

{\{\psi_{j,\lambda}(x)=(2N)^{j/2}\psi((2N)^{j}x-\lambda),\,j\in\mathbb{Z},\,%
\lambda\in\Lambda\}}

to be a frame for

L
2

⁢

(
ℝ
)

{L^{2}(\mathbb{R})}

.
The proposed inequalities are stated in terms of Fourier transforms and hold without any decay assumptions on the generator of such a system.
Characterizing realcompact locales via remainders
Authors: Dube Themba 
Published: May 2019

Abstract
We prove that a completely regular locale L is realcompact if and only if the “remainder”

β
⁢
L

∖
L

{\beta L\smallsetminus L}

is the join of the zero-sublocales of

β
⁢
L

{\beta L}

that miss L. This extends a result of Mrówka which characterizes realcompact spaces in terms of their remainders in Stone–Čech compactifications. We prove that

β
⁢
L

∖
L

{\beta L\smallsetminus L}

is Lindelöf if and only if L is of countable type, where the latter is defined for locales exactly as for spaces, subject to replacing subspaces with sublocales.
Influence of radiation-crosslinking on the elongation behaviour of glass-fibre-filled sheets in the thermoforming process
Authors: Wittmann Lisa-Maria , Wolf Michael , Kurth Katharina , Drummer Dietmar 
Published: May 2019

Abstract
Thermoforming is one of the most important processes in polymer processing. In the packaging industry, thermoformed parts such as blister packs are manufactured from amorphous plastics such as polystyrene (PS) or polyvinyl chloride (PVC). In the field of semi-crystalline thermoplastics, mainly standard thermoplastics, such as, for example, polypropylene (PP), polyethylene (PE), or polyethylene terephthalate (PET), are used. There is limited literature dealing with the thermoforming of thin filled systems. Filler bonding, in particular, represents a major challenge in strain rheology. Electron irradiation is a way to generate improved filler-matrix bonding. In this study, the influence of fillers and radiation-crosslinking on the elongation behaviour and on the wall thickness distribution was investigated. At higher areal draw ratios, an enormous benefit of radiation-crosslinking of thin filled sheets is shown. While non-crosslinked specimens could not be formed, it was possible to thermoform radiation-crosslinked sheets filled with 10 vol.% glass fibres. Furthermore, with the higher areal draw ratio, the influence of the filler orientation on the stretching behaviour became more apparent.
Enteroprotective effect of Tsukamurella inchonensis on streptozotocin induced type 1 diabetic rats
Authors: Mesgari-Abbasi Mehran , Ghaderi Solin , Khordadmehr Monire , Nofouzi Katayoon , Tayefi-Nasrabadi Hossein , McIntyre Graham 
Published: May 2019

Abstract

Objectives
Enteropathy is one of the most important complications of diabetes mellitus. The present study determined the possible effects of Tsukamurella inchonensis (Ti) on diabetes enteropathy on rat small intestine.

Materials and methods
A total of 40 rats were divided into four groups of 10. Diabetes was induced by streptozotocin. Oral administration of Ti at dose of 105 and 107 CFU/rat was performed in two groups continuously for 14 days. The third and fourth groups received normal saline as the diabetic and negative control groups, respectively. The blood and intestine tissue samples were taken on 21st day post treatment for biochemical and pathological evaluations.

Results
Significant differences were found in serum glucose, cholesterol and triglycerides values together with in CAT and SOD activities, MDA level and IL-6 concentration in both Ti treated groups in comparison with the diabetic rats. Moreover, there were severe pathological changes including degeneration of intestinal mucosa, mononuclear cell infiltration, decreasing number of goblet cells and villous length associated with increasing in villous thickness on the diabetic rats which markedly attenuated in both Ti recipient groups.

Conclusion
In conclusion, it seems that oral administration of Ti may improve intestinal damage in diabetic patients by modulation of intestinal antioxidant defense system.
Characterization of Sandstone for Application in Blast Analysis of Tunnel
Authors: Mishra Sunita , Chakraborty Tanusree , Basu Dipanjan , Lam Nelson 
Published: May 2019

Abstract
The present work aims to gain an understanding of the stress-strain response of sandstone, a sedimentary rock, under high loading rate and further determine the appropriate specimen dimension of sandstone for dynamic testing. The high strain rate characterization of sandstone is done for two different diameters and five different slenderness ratios of sandstone specimens using a 76-mm–diameter split Hopkinson pressure bar (SHPB) device. The stress-strain response of sandstone is studied by systematically varying the length of the striker bars and gas gun pressure of the SHPB device. The petrological and static characterizations of the sandstone rock are also carried out. Finally, the appropriate specimen size of sandstone for SHPB testing is proposed by checking the strength gain of the rock and amount of energy absorbed during the tests. Further, finite element (FE) analysis of the SHPB test on sandstone is performed using the strain rate–dependent Johnson-Holmquist (JH-2) model available in the FE software, LS-DYNA. The simulation results are compared with the experimental data in order to determine the parameters of the JH-2 model for sandstone. A parameter database is thus prepared for sandstone. The determined parameters are then used in the blast analysis of tunnels for a 20-kg trinitrotoluene (TNT) explosion and the tunnel response is studied.
Optimization of A-TIG Welding Process Parameters for P92 (9Cr-0.5Mo-1.8W-VNb) Steel by Using Response Surface Methodology
Authors: Maduraimuthu V. , Vasantharaja P. , Vasudevan M. , Panigrahi B. S. 
Published: May 2019

Abstract
Response surface methodology (RSM) is a mathematical and statistical technique useful for the modeling and optimization of processes in which a response of significance is influenced by a number of process parameters called input variables. The major concern faced by fabrication engineers during activated tungsten inert gas (A-TIG) welding is the selection of the optimum combination of input variables for achieving the desired weld bead geometry. In this research work, the optimization of A-TIG welding process parameters for P92 (9Cr-0.5Mo-1.8W-VNb) steel have been carried out using RSM. The design matrix for conducting experiments was generated using the central composite design of RSM. The four input process variables, such as welding current, torch speed, arc gap, and electrode tip angles, are varied at five levels. A-TIG bead-on-plate welds were made on a 10 mm-thick P92 steel plate as per the combination of input parameters given by the design matrix. Weld bead geometry, such as the depth of penetration, bead width, and width of the heat-affected zone, were measured and recorded as responses. Second-order response surface models were developed for predicting the response for the set of given input process parameters. Moreover, the response optimization was carried out for obtaining the maximum depth of penetration, minimum bead width, and target heat-affected zone width using the desirability approach. The validation experiments were carried out on the determined optimized process parameters, and it was found that there was good agreement between the predicted weld bead dimensions and actual values obtained during the experiments.
Exceptional diazoxide sensitivity in hyperinsulinaemic hypoglycaemia due to a novel HNF4A mutation
Authors: Arya Ved Bhushan , Kalitsi Jennifer , Hickey Ann , Flanagan Sarah E , Kapoor Ritika R 
Published: May 2019

Summary
Diazoxide is the first-line treatment for patients with hyperinsulinaemic hypoglycaemia (HH). Approximately 50% of patients with HH are diazoxide resistant. However, marked diazoxide sensitivity resulting in severe hyperglycaemia is extremely uncommon and not reported previously in the context of HH due to HNF4A mutation. We report a novel observation of exceptional diazoxide sensitivity in a patient with HH due to HNF4A mutation. A female infant presented with severe persistent neonatal hypoglycaemia and was diagnosed with HH. Standard doses of diazoxide (5 mg/kg/day) resulted in marked hyperglycaemia (maximum blood glucose 21.6 mmol/L) necessitating discontinuation of diazoxide. Lower dose of diazoxide (1.5 mg/kg/day) successfully controlled HH in the proband, which was subsequently confirmed to be due to a novel HNF4A mutation. At 3 years of age, the patient maintains age appropriate fasting tolerance on low dose diazoxide (1.8 mg/kg/day) and has normal development. Diagnosis in proband’s mother and maternal aunt, both of whom carried HNF4A mutation and had been diagnosed with presumed type 1 and type 2 diabetes mellitus, respectively, was revised to maturity-onset diabetes of young (MODY). Proband’s 5-year-old maternal cousin, also carrier of HNF4A mutation, had transient neonatal hypoglycaemia. To conclude, patients with HH due to HNF4A mutation may require lower diazoxide than other group of patients with HH. Educating the families about the risk of marked hyperglycaemia with diazoxide is essential. The clinical phenotype of HNF4A mutation can be extremely variable.

Learning points:

Awareness of risk of severe hyperglycaemia with diazoxide is important and patients/families should be accordingly educated.

Some patients with HH due to HNF4A mutations may require lower than standard doses of diazoxide.

The clinical phenotype of HNF4A mutation can be extremely variable.
Testing Pleiotropy vs. Separate QTL in Multiparental Populations
Authors: Boehm Frederick J , Chesler Elissa J , Yandell Brian S , Broman Karl W 
Published: May 2019

Abstract
The high mapping resolution of multiparental populations, combined with technology to measure tens of thousands of phenotypes, presents a need for quantitative methods to enhance understanding of the genetic architecture of complex traits. When multiple traits map to a common genomic region, knowledge of the number of distinct loci provides important insight into the underlying mechanism and can assist planning for subsequent experiments. We extend the method of Jiang and Zeng (1995), for testing pleiotropy with a pair of traits, to the case of more than two alleles. We also incorporate polygenic random effects to account for population structure. We use a parametric bootstrap to determine statistical significance. We apply our methods to a behavioral genetics data set from Diversity Outbred mice. Our methods have been incorporated into the R package qtl2pleio.
A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast Cryptococcus neoformans
Authors: Burke Jordan E , Longhurst Adam D , Natarajan Prashanthi , Rao Beiduo , Liu John , Sales-Lee Jade , Mortensen Yasaman , Moresco James J , Diedrich Jolene K , Yates John R , Madhani Hiten D 
Published: May 2019

Abstract
The human pathogenic yeast Cryptococcus neoformans silences transposable elements using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA-dependent RNA polymerase, Rdp1, and two partially redundant Dicer enzymes, Dcr1 and Dcr2, but is independent of histone H3 lysine 9 methylation. We describe here an insertional mutagenesis screen for factors required to suppress the mobilization of the C. neoformans HARBINGER family DNA transposon HAR1. Validation experiments uncovered five novel genes (RDE1-5) required for HAR1 suppression and global production of suppressive endo-siRNAs. The RDE genes do not impact transcript levels, suggesting the endo-siRNAs do not act by impacting target transcript synthesis or turnover. RDE3 encodes a non-Dicer RNase III related to S. cerevisiaeRnt1, RDE4 encodes a predicted terminal nucleotidyltransferase, while RDE5 has no strongly predicted encoded domains. Affinity purification-mass spectrometry studies suggest that Rde3 and Rde5 are physically associated. RDE1 encodes a G-patch protein homologous to the S. cerevisiaeSqs1/Pfa1, a nucleolar protein that directly activates the essential helicase Prp43 during rRNA biogenesis. Rde1 copurifies Rde2, another novel protein obtained in the screen, as well as Ago1, a homolog of Prp43, and numerous predicted nucleolar proteins. We also describe the isolation of conditional alleles of PRP43, which are defective in RNAi. This work reveals unanticipated requirements for a non-Dicer RNase III and presumptive nucleolar factors for endo-siRNA biogenesis and transposon mobilization suppression in C. neoformans.
Frequency of Malignancy in Multinodular Goiter in a Tertiary Level Hospital in Bangladesh.
Authors: Rashid Md Shazibur , Akter Najnin , Majumder Jahangir Alam , Delwar AHM , Mustafa Md Golam 
Published: May 2019

Objectives: To determine the frequency of thyroid malignancy in clinically or zoographically multinodular goiter in patients undergoing thyroidectomy in Cumilla Medical College Hospital, Bangladesh.
Methods: A cross sectional study was carried out at the department of Otolaryngology and Head Neck Surgery of Cumilla Medical College Hospital during the period from January 2016 to January 2019. This study includes all patients admitted and undergoing surgery with multinodular goiter.
Results: Out of 146 patients 118 patients were female and 28 patients were male with female male ratio is 4.2:1. Out of 146 patients 13 patients were found histologically thyroid malignancy. Among them 8 patients were male and 5 patients were female. Papillary carcinoma was found in all cases.
El tópico de “los orígenes ideológicos” de las revoluciones de independencia como problema. Una relectura a partir de Tradición política española e ideología revolucionaria de Mayo, de Tulio Halperin Donghi
Authors: Palti Elías 
Published: May 2019

Uno de los temas centrales en la historia de ideas en América Latina es el de los orígenes ideológicos de las revoluciones de independencia. La cuestión ha dado lugar a largas disputas en cuanto a la filiación de las ideas que permitieron la emergencia del discurso revolucionario. Según se intenta mostrar en este ensayo a partir de una relectura de Tradición política española e ideología revolucionaria de Mayo, de Tulio Halperin Donghi, ese afán por determinar cuáles fueron las ideas precursoras del discurso revolucionario resulta inconducente, dado que no hay forma de establecer cuál es el origen preciso de una idea particular. Y aun en caso de poder hacerlo, resulta irrelevante para comprender la naturaleza de ese discurso. De lo que se trata, en cambio, es de entender cómo esas ideas, sea cual fuere su origen, se rearticularon en función de problemáticas ya completamente diversas de aquellas a partir de las cuales surgieron. En el presente trabajo se hace un esbozo de la serie de torsiones que fueron experimentando los conceptos clave del pensamiento tradicional hispano y de cómo ésas terminarían abriendo las puertas a la emergencia de un tipo de discurso que escaparía ya de sus marcos.
Nephrin Signaling Results in Integrin β1 Activation
Authors: Dlugos Christopher Philipp , Picciotto Cara , Lepa Carolin , Krakow Malte , Stöber Antje , Eddy Mee-Ling , Weide Thomas , Jeibmann Astrid , P. Krahn Michael , Van Marck Veerle , Klingauf Jürgen , Ricker Andrea , Wedlich-Söldner Roland , Pavenstädt Hermann , Klämbt Christian , George Britta 
Published: May 2019

Significance Statement
The slit diaphragm protein Nephrin, which is essential for an intact glomerular filter, signals from the podocyte slit diaphragm to the Actin cytoskeleton and induces lamellipodia formation. The authors present evidence that Nephrin activation results in activation of Integrin β1 in a cultured human podocyte model, and that C3G, a guanine nucleotide exchange factor of the small GTPase Rap1, is involved in Nephrin signaling to Integrin β1. In vivo, in Drosophila nephrocytes, the Nephrin ortholog Sticks and stones is necessary for correct targeting of Integrin β1. These findings indicate that Nephrin can mediate a signaling pathway that results in activation of Integrin β1 at focal adhesions, which may affect podocyte attachment to the extracellular matrix.

Background
Patients with certain mutations in the gene encoding the slit diaphragm protein Nephrin fail to develop functional slit diaphragms and display severe proteinuria. Many adult-onset glomerulopathies also feature alterations in Nephrin expression and function. Nephrin signals from the podocyte slit diaphragm to the Actin cytoskeleton by recruiting proteins that can interact with C3G, a guanine nucleotide exchange factor of the small GTPase Rap1. Because Rap activity affects formation of focal adhesions, we hypothesized that Nephrin transmits signals to the Integrin receptor complex, which mediates podocyte adhesion to the extracellular matrix.

Methods
To investigate Nephrin’s role in transmitting signals to the Integrin receptor complex, we conducted genetic studies in Drosophila nephrocytes and validated findings from Drosophila in a cultured human podocyte model.

Results
Drosophila nephrocytes form a slit diaphragm–like filtration barrier and express the Nephrin ortholog Sticks and stones (Sns). A genetic screen identified c3g as necessary for nephrocyte function. In vivo, nephrocyte-specific gene silencing of sns or c3g compromised nephrocyte filtration and caused nephrocyte diaphragm defects. Nephrocytes with impaired Sns or C3G expression displayed an altered localization of Integrin and the Integrin-associated protein Talin. Furthermore, gene silencing of c3g partly rescued nephrocyte diaphragm defects of an sns overexpression phenotype, pointing to genetic interaction of sns and c3g in nephrocytes. We also found that activated Nephrin recruited phosphorylated C3G and resulted in activation of Integrin β1 in cultured podocytes.

Conclusions
Our findings suggest that Nephrin can mediate a signaling pathway that results in activation of Integrin β1 at focal adhesions, which may affect podocyte attachment to the extracellular matrix.
Бродвей в разрезе
Authors: Павлюк Семен Геннадьевич , Никогосян Каринэ Сергеевна 
Published: May 2019

Бродвей — самая известная улица Нью-Йорка — проходит через весь остров Манхэттен и многие его вернакулярные районы. Полевое исследование функциональной, социально-экономической, архитектурной и ментальной дифференциации улицы от Боулинг-Грин на юге Манхэттена до 142-й стрит в Испанском Гарлеме позволило отработать методику профильного районирования территории, а также выявить 16 уникальных районов на выбранном отрезке. Районы получились функциональными по сути, однако их выделение базируется на границах внутригородских вернакулярных районов. Получается, что Бродвей как важная общественно-торговая магистраль формирует окрестный городской ландшафт, но роль и степень выраженности вернакулярных районов, по которым проходит улица, остается значительной, а зачастую — решающей1.
____________________________
1 Статья подготовлена при поддержке РФФИ (грант No 17-03-00848).