bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insulin Pump Therapy—Patient and Provider Perceptions
Authors: PEREZ-NIEVES MAGALY , GAREY COLLEEN , FAN LUDI , MCAULIFFE-FOGARTY ALICIA H. 
Published: June 2018

This study aimed to identify the benefits and challenges of insulin pump therapy from both the patient and provider perspective.
One hundred current multiple daily injection (MDI) users, including 31 former pump users, and 250 current pump users were recruited from myGlu.org, and 61 healthcare providers were recruited from T1D Exchange Clinic Network and American Association of Diabetes Educators to complete an online survey.
Reports of decreased HbA1Cs (A1C) after pump initiation differed significantly between patients and providers (p = .001); more former users reported their A1C increased compared to current users (p = .03). Significantly more current and MDI had recent A1Cs &lt; 7.0% than former users (p = .005).
The most common reason patients reported stopping pump therapy was an increase in blood glucose; however, providers reported that the most common reason for patients to stop pump therapy was cost. Over 90% of current users were satisfied with their pump and providers report that 92% of their patients were satisfied with their pump; however, only 29% of former pump users reported that they were satisfied with their pump.
HCP’s perceptions of the patients’ experience with pumps differs from patients’ experience, which highlights the importance of patient-centered communication to understand an individual patient’s preferences, and challenges in managing diabetes to select an insulin treatment plan that meets both patient and HCP goals.

Disclosure
M. Perez-Nieves: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company. C. Garey: None. L. Fan: Employee; Self; Eli Lilly and Company. A.H. McAuliffe-Fogarty: Advisory Panel; Self; Novo Nordisk Inc..
Achievement of Glycemic Targets when Switching from Basal-Bolus Therapy to V-Go for Insulin Delivery in Type 2 Diabetes
Authors: HUNDAL RIPU S. , KOWALYK STEPHAN , CASES JANE , AL-KARADSHEH AMER , WAKIM AMANDA P. , DOYLE MELISSA , SINK JOHN H. , SPENCE ADRIENNE , BREWER JAMIE L. , NIKKEL CARLA C. 
Published: June 2018

Achieving A1C targets is a fundamental component of quality measures such as HEDIS and Star ratings. A typical basal-bolus insulin regimen requires 4 insulin injections a day. Adherence decreases as the number of injections increases and non-adherence to therapy is a primary reason for failure to achieve glycemic control. Less invasive options for insulin delivery may improve patient adherence leading to positive clinical outcomes. This multi-state retrospective analysis evaluated the achievement of glycemic targets compared to prior therapy in 186 patients switched from a basal-bolus regimen to a 24-hour wearable insulin delivery device (V-Go). At baseline, mean A1C was 9.1%, weight 219 lbs and insulin total daily dose (TDD) was 84 u/day across a mean of 4.3 injections/day. Forty-five percent of patients were poorly controlled (A1C &gt; 9%) and less than 30% had achieved an A1C &lt; 8% despite basal-bolus therapy. After 7 months of V-Go use, changes from baseline in A1C and TDD were significant (P&lt;0.0001). Mean change (95% CI) in A1C was -1.02% (-1.24, -0.78) and TDD was reduced by 32% or 25 u/day (31, 19). Weight did not significantly change. Switching to V-Go, resulted in significant improvement to achievement of glycemic targets (90% increase in A1C values &lt; 8% and 50% decrease in A1C values &gt; 9%) compared to prior basal-bolus regimen, having positive implications on quality metrics.

Disclosure
R.S. Hundal: Speaker's Bureau; Self; Valeritas, Inc., Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., AstraZeneca, Novo Nordisk Inc., Amarin Corporation, Eli Lilly and Company, Merck & Co., Inc. S. Kowalyk: Speaker's Bureau; Self; Valeritas, Inc.. J. Cases: None. A. Al-Karadsheh: None. A.P. Wakim: Speaker's Bureau; Self; Versartis, Inc.. Research Support; Self; Valeritas, Inc.. M. Doyle: None. J.H. Sink: Other Relationship; Self; Janssen Pharmaceuticals, Inc., valeritas. Speaker's Bureau; Self; Novo Nordisk Inc.. Consultant; Self; Becton, Dickinson and Company. A. Spence: None. J.L. Brewer: Speaker's Bureau; Self; Valeritas, Inc., Janssen Pharmaceuticals, Inc. C.C. Nikkel: Employee; Self; Valeritas, Inc.. Stock/Shareholder; Self; Valeritas, Inc..
Supramolecular Biomaterials as a Biomimetic Platform for Investigating Immunopathological Processes of Human Type 1 Diabetes
Authors: BECKER MATTHEW , SEROSKI DILLON , STIMPSON SCOTT , MATHEWS CLAYTON E. , HUDALLA GREG , PHELPS EDWARD A. 
Published: June 2018

A major goal of type 1 diabetes (T1D) research is development of state-of-the-art devices that recreate the human islet microenvironment to help elucidate the molecular and cellular mechanisms of beta cell loss due to autoimmunity. We recently reported a novel synthetic biomaterial technology to form hydrogels from a pair of oppositely-charged peptides that co-assemble into a network of interpenetrating β-sheet nanofibers. Here, we explored the potential of this biomaterial, referred to as “CATCH” for Co-Assembly Tags based on Charge complementarity, to serve as a 3D microenvironment for studies of the islet—immune cell interface within the context of human T1D. Supramolecular CATCH hydrogels offer a number of key advantages for engineering islet biomimetic microenvironments: 1) they are fabricated via self-assembly at neutral pH and 37°C; 2) require no chemical reaction to form; and 3) are intrinsically capable of installing folded proteins or peptides via covalent fusion to one of the synthetic peptides sequences. In initial experiments, we established that CATCH hydrogels are cyto-compatible with human beta cells via encapsulation of BetaLox5 cells (βL5), an immortalized human beta cell line, by demonstrating strong viability (Calcein-AM/Ethidium homodimer-1 stain) of encapsulated βL5 at 3 and 24 hours after gelation similar to βL5 seeded on 2D surfaces. CATCH gels also showed promise as a viable platform for interrogating the engagement of autoreactive immune cells with human beta cells. Engineered CD8+ human T cell avatars expressing human T cell receptors for the islet antigen pre-proinsulin co-embedded into CATCH hydrogels with βL5 cells show strong beta cell killing in 3D by T cells over an 18-hour period (assessed via loss of TMRM staining of mitochondrial membrane potential). These initial successes are guiding our development of CATCH hydrogels for further detailed 3D studies of islet—immune cell interactions relevant to human T1D.

Disclosure
M. Becker: None. D. Seroski: None. S. Stimpson: None. C.E. Mathews: None. G. Hudalla: None. E.A. Phelps: None.
Closing the Loop with OpenAPS in People with Type 1 Diabetes—Experience from Italy
Authors: PROVENZANO VINCENZO , GUASTAMACCHIA EDOARDO , BRANCATO DAVIDE , CAPPIELLO GERARDO , MAIOLI ANTONIO , MANCINI RAFFAELE , CRISPINO GIUSEPPE , MONTE ARIELLA DE , TURCO SALVATORE , TONOLO GIANCARLO 
Published: June 2018

Background: Since 2017, people with type 1 diabetes (T1D) in Italy began to use spontaneously an Artificial Pancreas Systems (APS) with off-label use of existing insulin pumps, continuous glucose monitors (CGM), and open source software (known as OpenAPS). Aim of this study is to understand if closing the loop with OpenAPS is effective to improve the glucose control in T1D diabetes.
Methods: We studied 30 people (male/female = 19/11; age = 35.9 years ± 12.52 DS) with T1D who shared and self-reported their data and experiences from using this system. All the people included in the study used a CGM Dexcom G5 and insulin pump Dana Diabecare R; the implementation of OpenAPS realized a so called hybrid closed loop system. Main outcomes were A1c and % of time into hypoglycemia (glycemia &lt; 70 mg%, %TIHypo), before and 3 months after closing the loop. Secondary outcomes were % of time into hyperglycemia (glycemia &gt; 180 mg%, %TIHyper) and time into range (glycemia between 70 and 180 mg%, TIR).
Results: We observed a significant decrease of A1c (from 7.17% ± 0.49 DS to 6.61% ± 0.47 DS; p &lt; 0.05) and of %TIHypo (from 8.55% ± 5.81 DS to 2.48% ± 1.16 DS). We also observed a decrease of TIHyper and an increase of TIR, but the differences were not statistically significant. All patients were satisfied of OpenAPS use and only one patient dropped out, on advice of his diabetologist. No any serious adverse event was recorded (diabetic ketoacidosis, serious hypoglycemia).
Discussion and Conclusions: Closing the loop with OpenAPS in people with T1D is effective in decreasing A1c and %TIHypo, without any serious adverse event. Of note, these results were obtained with people who showed a good baseline metabolic control (A1c of 7.17%). However, we need to study OpenAPS implementation on a larger sample of people with T1D and with a more prolonged follow-up.

Disclosure
V. Provenzano: None. E. Guastamacchia: None. D. Brancato: None. G. Cappiello: None. A. Maioli: None. R. Mancini: None. G. Crispino: None. A. De Monte: None. S. Turco: None. G. Tonolo: None.
Real-World Data from the MiniMed™ 670G System Commercial Launch—The First 1,052 Patients Using the System for Three Months
Authors: AGRAWAL PRATIK , STONE MICHAEL , GOPALAKRISHNAN SHWETA , FOGEL CATHERINE , LEE SCOTT W. , KAUFMAN FRANCINE R. 
Published: June 2018

The Medtronic MiniMed™ 670G hybrid closed-loop system with SmartGuard™ technology was released for commercial use in the U.S. in March 2017. Sensor glucose (SG) and device utilization data from the initial open-loop Manual Mode and closed-loop Auto Mode periods were analyzed for the first 1052 patients and compared to those from the MiniMed™ 670G system pivotal trial1.
De-identified data voluntarily uploaded to CareLink™ Personal software, from 3/17/17 to 11/11/17, were evaluated monthly, for 3 months. Data for 12,758 patient-days in Manual Mode and 142,065 patient-days after Auto Mode start were compared to results of the MiniMed™ 670G pivotal trial (124 patients aged 14-75 years) conducted from 6/2/15 to 3/7/16.
The percentage of time in Auto Mode, after initiation, was &gt;85% over the 3 months for the entire commercial cohort. The SG values across glucose ranges were comparable to pivotal trial data (Table).
These findings indicate that outcomes data for the first 1052 patients using the commercial MiniMed™ 670G system mirrored the pivotal trial outcomes. Further, the increased time in target range and decreased hypoglycemia and hyperglycemia were sustained over 3 months.
Pivotal TrialCommercial LaunchManual ModeAuto ModeManual ModeAuto Mode Month 1Auto Mode Month 2Auto Mode Month 3Patients, N1241241052105210521052Auto Mode Use, %-87.20-88.6086.7885.96Mean SG, mg/dL150.2150.78157.02149.84150.30150.75Percentage of time in SG range, mg/dL&lt;500.850.520.380.300.320.33&lt;541.330.780.600.460.500.52&lt;705.472.952.652.072.212.2370-18067.1372.6167.3975.0074.3674.07&gt;18027.424.4529.9622.9323.4323.70&gt;2506.945.587.494.504.865.14
1. Garg SK, Weinzimer SA, Tamborlane WV, et al. Glucose outcomes with the in-home use of a hybrid closed-loop insulin delivery system in adolescents and adults with type 1 diabetes.
Diabetes Technol Ther. 2017;19:155-163.

Disclosure
P. Agrawal: None. M. Stone: None. S. Gopalakrishnan: Employee; Self; Medtronic. C. Fogel: Employee; Self; Medtronic. S.W. Lee: Employee; Self; Medtronic. F.R. Kaufman: Employee; Self; Medtronic.
Blasphemy, the Fate of Ahmadiyya in Lombok and a Critique of Religious Discourse
Authors: Masnun M.Ag. 
Published: June 2018

Abstract
Though Indonesia has claimed a principle of Bhinneka Tunggal Ika ("different but one"), in reality the country has faced fragmentation over the differences in its society, with its people blaspheming and killing each other. Ironically, the inter-religious conflict which has occurred is no longer between practitioners of different religions, but between practitioners of the same religions. This article is based on observational research conducted by the writer during his time in an area which has faced relatively intense violence: Lombok. Observations indicate that several types of violence are occurring in this area, namely cultural violence, social violence, gender violence, and violence in the name of religion. This last type of violence has been particularly dominant in Lombok, which is popularly known as “the island of a thousand mosques”. One form of violence in the name of religion is violence against the area’s Ahmadiyya population. One may ask, then, why is violence still used and considered a superior approach to problem solving than non-violence? Why are people trapped in the logic of difference and forget that different peoples have meeting points? How can these differences be dealt with so that they do not become self-destructive forces?
Metaphorical modelling in the case of cosmetic companies’ image development
Authors: Ivantsiv Oryslava 
Published: June 2018

AbstractThe article focuses on metaphorical modelling as a means of corporate image development. The research data includes an electronic corpus of 185 press releases issued by five international cosmetic companies. A methodology of analysing metaphorical models based on the consideration of the model’s frame-slot structure was applied. The study resulted in the singling out of two major metaphorical clusters within the corporate discourse of image-making – BUSINESS IS A HUMAN BEING and BUSINESS IS ART. Although these models do not embrace the whole range of sources of metaphorical expansion, they nevertheless essentially contribute to creating a relatively holistic image of a cosmetic company as a perfect organism that produces masterpieces to meet the needs and expectations of the target audience.
Validity of Clinical Small–Fiber Sensory Testing to Detect Small–Nerve Fiber Degeneration
Authors: Ridehalgh Colette , Sandy-Hindmarch Oliver P. , Schmid Annina B. 
Published: June 2018

Background Small–nerve fiber, or small-fiber, degeneration commonly occurs in patients with peripheral neuropathies, resulting in a deterioration of nerve function. Currently, the gold standard to identify small-fiber degeneration is through skin biopsy. Simple clinical tests aim to identify small-fiber degeneration, but their validity remains unknown. Objectives To examine the validity of clinical tests to assess small–nerve fiber degeneration, using carpal tunnel syndrome as a model neuropathy. Methods One hundred seven participants (22 healthy, 85 with carpal tunnel syndrome) in this prospective, cross-sectional diagnostic accuracy study underwent pinprick testing of the index finger and were assessed for cold detection threshold and warm detection threshold using quantitative sensory testing. In a subgroup of patients with carpal tunnel syndrome (n = 51), cold and warm sensations were also tested, using coins at room and body temperature, respectively. The validity of these clinical tests was established against intra-epidermal nerve fiber density measured in skin biopsies from the index finger. Results Optimal validity occurred with clusters of tests. Specifically, normal warm or cold sensation is highly sensitive to rule out small-fiber degeneration (sensitivity, 0.98; 95% confidence interval [CI]: 0.85, 0.99), but has a low specificity (0.20; 95% CI: 0.03, 0.52). By contrast, a reduction in pinprick is highly specific (0.88; 95% CI: 0.72, 0.95), and so can be used to rule in small-fiber degeneration. For quantitative sensory testing, the highest specificity (0.83) occurs for warm detection threshold and the highest sensitivity (0.84; 95% CI: 0.72, 0.91) for cold detection threshold or warm detection threshold. Conclusion Pinprick testing, followed by warm and cold tests if pinprick is normal, is a valid and cost-effective method to detect small-fiber degeneration. For quantitative sensory testing, warm detection threshold is useful for ruling in small-fiber degeneration. To rule out small-fiber degeneration, both cold detection threshold and warm detection threshold must be negative. Level of Evidence Diagnosis, level 2. J Orthop Sports Phys Ther 2018;48(10):767–774. Epub 22 Jun 2018. doi:10.2519/jospt.2018.8230
Perceptions of Rehabilitation and Return to Sport Among High School Athletes With Anterior Cruciate Ligament Reconstruction: A Qualitative Research Study
Authors: DiSanti Justin , Lisee Caroline , Erickson Karl , Bell David , Shingles Michael , Kuenze Christopher 
Published: June 2018

Background Adolescent athletes struggle to return to sport following anterior cruciate ligament reconstruction (ACLR) for physical and psychosocial reasons. The ability to integrate contextual evidence obtained directly from patients with the growing body of quantitative rehabilitation research may aid clinicians in taking an evidence-based approach to rehabilitation and return to sport within the adolescent population. Objectives To assess perceived barriers to return to sport, as well as positive and negative factors influencing recovery, among high school athletes with recent history of ACLR. Methods This phenomenographic cross-sectional study included a sample of 10 high school–aged individuals (7 female, 3 male; mean ± SD age, 16.8 ± 1.1 years; time since surgery, 5.5 ± 1.4 months) who underwent ACLR and had not returned to sports. Participants completed a semi-structured interview focused on attitudes related to return to sport, perceived physical or psychosocial barriers to physical activity and return to sport, and rehabilitation characteristics that may facilitate or hinder return to sport. Results Participants reported psychosocial barriers to return to sport with greater consistency than physical barriers. Consistently reported barriers included the feeling that sport-based activities were now associated with injury, a persistent sense of uncertainty regarding full recovery, and the sense that comparison to others with ACLR by parents or coaches hindered their ability to make progress in rehabilitation. Conclusion Early identification of athletes at risk for persistent psychosocial barriers, such as fear of reinjury and uncertainty regarding full recovery, and establishment of peer mentoring groups to facilitate psychosocial support throughout the rehabilitation process may be key components of a gradual, patient-centered approach to improving mental and physical readiness for return to sport. J Orthop Sports Phys Ther 2018;48(12):951–959. Epub 22 Jun 2018. doi:10.2519/jospt.2018.8277
Türk Edebiyatı Tarihine Bir Katkı Olarak Modern Türk Edebiyatı
Authors: Ceylan Sercan 
Published: June 2018

21. yüzyıla gelinceye değin Türk Edebiyatı
tarihiyle ilgili pek çok çalışma ortaya konmuş ve bunlar büyük oranda yazarlarının
yöntemsel, biçimsel ya da düşünsel tercihlerine bağlı kalarak didaktizmi /
öğreticiliği hedefliyor görünmüşlerdir. Bu çalışmalar edebiyat, dil ve kültür zincirini
ilerletmek, tanıtıcı ve açıklayıcı bilgileri okur için bir drajeye dönüştürmek
ve edebiyat eğitimi bakımından derli toplu bir kaynak olmak görevlerini
üstlenirler. Dil devrimi öncesinden, Abdülhalim Memduh’un Tarih-i Edebiyat-ı Osmaniye’sinden başlayarak özgül bir disipline
kavuşan edebiyat tarihçiliğinin genellikle 20. yüzyılda devinime kavuştuğunu
görüyoruz. Bu yazıda ise Türk edebiyatı tarihindeki yeri, nitelikleri, işleviyle Modern
Türk Edebiyatı mercek altına alınacaktır.
Lookup Table Algorithm for Error Correction in Color Images
Authors: Abdulsattar Ruaa Alaadeen , Hussein M. Ali Nada 
Published: June 2018

Error correction and error detection techniques are often used in wireless transmission systems. A color image of type BMP is considered as an application of developed lookup table algorithms to detect and correct errors in these images. Decimal Matrix Code (DMC) and Hamming code (HC) techniques were integrated to compose Hybrid Matrix Code (HMC) to maximize the error detection and correction. The results obtained from HMC still have some error not corrected because the redundant bits added by Hamming codes to the data are considered inadequate, and it is suitable when the error rate is low for detection and correction processes. Besides, a Hamming code could not detect large burst error period, in addition, the have same values sometimes which lead to not detect the error and consequently increase the error ratio. The proposed algorithm LUT_CORR is presented to detect and correct errors in color images over noisy channels, the proposed algorithm depends on the parallel Cyclic Redundancy Code (CRC) method that's based on two algorithms: Sarwate and slicing By N algorithms. The LUT-CORR and the aforementioned algorithms were merged to correct errors in color images, the output results correct the corrupted images with a 100 % ratio almost. The above high correction ratio due to some unique values that the LUT-CORR algorithm have. The HMC and the proposed algorithm applied to different BMP images, the obtained results from LUT-CORR are compared to HMC for both Mean Square Error (MSE) and correction ratio.Â The outcome from the proposed algorithm shows a good performance and has a high correction ratio to retrieve the source BMP image.
Patientâ€™s Cancer Categorization Based On Jaccard and Venn Techniques
Authors: Omar Nurul Aswa , Efendi Riswan , Wahid Norfaradilla , Mohd Yasin Afiq Luqman 
Published: June 2018

Under some circumstances, hospitals and clinics need to know the preliminary patientâ€™s disease categorization, such as H1N1, Dengue, HIV/AIDS and others. However, categorizing patients will be useful in the future if the hospitals Â properly recorded their patient criteria and crucial details such as patientâ€™s name, symptoms, temperature and others. There are many benefits by grouping the patients together such as the hospitals will know how to provide an appropriate medicine to the patient, which patient will get the highest priority and should be quarantined.Â It is very important to know how to group the patients by using their symptoms detected. This study will focus on patients with cancer problems using Jaccard index and Venn diagram techniques. Their data will be collected from a hospital and the patients are selected randomly. Patients with lungs, brain and breast cancer will be selected in this study.
Production and Circulation of Vernacular Italian Books Related to the Jesuit Mission in Japan in the Sixteenth Century
Authors: Favi Sonia 
Published: June 2018

The reports and histories compiled by the members of the Society of Jesus in the second half of the sixteenth century were among the earliest European sources to treat ‘Japan’ as a geographical and political reality. The peculiarity of the Jesuit approach, focused on research and adaptation, is reflected in the variety of their contents, encompassing descriptions of geography, politics, society, language, religion and art. The reports were also the earliest sources on Japan to reach a wider public in Europe. They were not only delivered to Coimbra, Rome and to the different Jesuit houses, but also distributed commercially, in the form of letter-books, throughout Europe. It can be presumed that the impact of the letter-books on European readership was enhanced by the growing popularity of periodical publications and by the expansion of the publishing market. This paper will use the reports published in vernacular Italian as a case study, and investigate the nature of such readership and how the reports fit into the Italian book market of the sixteenth century. It will analyse them in light of the cultural and economical processes that led to their production and circulation, focusing on publishing houses, editions and formats, in order to evaluate the editorial policies that led to their circulation.