bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis of randomised controlled trials testing behavioural interventions to promote household action on climate change
Authors: Nisa Claudia F. , Bélanger Jocelyn J. , Schumpe Birga M. , Faller Daiane G. 
Published: October 2019

AbstractNo consensus exists regarding which are the most effective mechanisms to promote household action on climate change. We present a meta-analysis of randomised controlled trials comprising 3,092,678 observations, which estimates the effects of behavioural interventions holding other factors constant. Here we show that behavioural interventions promote climate change mitigation to a very small degree while the intervention lasts (d = −0.093 95% CI −0.160, −0.055), with no evidence of sustained positive effects once the intervention ends. With the exception of recycling, most household mitigation behaviours show a low behavioural plasticity. The intervention with the highest average effect size is choice architecture (nudges) but this strategy has been tested in a limited number of behaviours. Our results do not imply behavioural interventions are less effective than alternative strategies such as financial incentives or regulations, nor exclude the possibility that behavioural interventions could have stronger effects when used in combination with alternative strategies.
Temperature affected guided wave propagation in a composite plate complementing the Open Guided Waves Platform
Authors: Moll Jochen , Kexel Christian , Pötzsch Serena , Rennoch Marcel , Herrmann Axel S. 
Published: October 2019

AbstractThe influence of temperature is regarded as particularly important for a structural health monitoring system based on ultrasonic guided waves. Since the temperature effect causes stronger signal changes than a typical defect, the former must be addressed and compensated for reliable damage assessment. Development of new temperature compensation techniques as well as the comparison of existing algorithms require high-quality benchmark measurements. This paper investigates a carbon fiber reinforced plastic (CFRP) plate that was fully characterized in previous research in terms of stiffness tensor and guided wave propagation. The same CFRP plate is used here for the analysis of the temperature effect for a wide range of ultrasound frequencies and temperatures. The measurement data are a contribution to the Open Guided Waves (OGW) platform: http://www.open-guided-waves.de. The technical validation includes initial results on the analysis of phase velocity variations with temperature and exemplary damage detection results using state-of-the-art signal processing methods that aim to suppress the temperature effect.
Synthetic Gauge Structures in Real Space in a Ring lattice
Authors: Das Kunal K. , Gajdacz Miroslav 
Published: October 2019

AbstractEmergence of fundamental forces from gauge symmetry is among our most profound insights about the physical universe. In nature, such symmetries remain hidden in the space of internal degrees of freedom of subatomic particles. Here we propose a way to realize and study gauge structures in real space, manifest in external degrees of freedom of quantum states. We present a model based on a ring-shaped lattice potential, which allows for both Abelian and non-Abelian constructs. Non trivial Wilson loops are shown possible via physical motion of the system. The underlying physics is based on the close analogy of geometric phase with gauge potentials that has been utilized to create synthetic gauge fields with internal states of ultracold atoms. By scaling up to an array with spatially varying parameters, a discrete gauge field can be realized in position space, and its dynamics mapped over macroscopic size and time scales.
Alkaline Phosphatase Treatment of Acute Kidney Injury in an Infant Piglet Model of Cardiopulmonary Bypass with Deep Hypothermic Circulatory Arrest
Authors: Davidson Jesse A. , Khailova Ludmila , Treece Amy , Robison Justin , Soranno Danielle E. , Jaggers James , Ing Richard J. , Lawson Scott , Lujan Suzanne Osorio 
Published: October 2019

AbstractAcute kidney injury (AKI) is associated with prolonged hospitalization and mortality following infant cardiac surgery, but therapeutic options are limited. Alkaline phosphatase (AP) infusion reduced AKI in phase 2 sepsis trials but has not been evaluated for cardiac surgery-induced AKI. We developed a porcine model of infant cardiopulmonary bypass (CPB) with deep hypothermic circulatory arrest (DHCA) to investigate post-CPB/DHCA AKI, measure serum/renal tissue AP activity with escalating doses of AP infusion, and provide preliminary assessment of AP infusion for prevention of AKI. Infant pigs underwent CPB with DHCA followed by survival for 4 h. Groups were treated with escalating doses of bovine intestinal AP (1, 5, or 25U/kg/hr). Anesthesia controls were mechanically ventilated for 7 h without CPB. CPB/DHCA animals demonstrated histologic and biomarker evidence of AKI as well as decreased serum and renal tissue AP compared to anesthesia controls. Only high dose AP infusion significantly increased serum or renal tissue AP activity. Preliminary efficacy evaluation demonstrated a trend towards decreased AKI in the high dose AP group. The results of this dose-finding study indicate that AP infusion at the dose of 25U/kg/hr corrects serum and tissue AP deficiency and may prevent AKI in this piglet model of infant CPB/DHCA.
Characterization of CYP71AX36 from Sunflower (Helianthus annuus L., Asteraceae)
Authors: Frey Maximilian , Klaiber Iris , Conrad Jürgen , Bersch Aylin , Pateraki Irini , Ro Dae-Kyun , Spring Otmar 
Published: October 2019

AbstractSesquiterpene lactones (STL) are a subclass of isoprenoids with many known bioactivities frequently found in the Asteraceae family. In recent years, remarkable progress has been made regarding the biochemistry of STL, and today the biosynthetic pathway of the core backbones of many STLs has been elucidated. Consequently, the focus has shifted to the discovery of the decorating enzymes that can modify the core skeleton with functional hydroxy groups. Using in vivo pathway reconstruction assays in heterologous organisms such as Saccharomyces cerevisiae and Nicotiana benthamiana, we have analyzed several cytochrome P450 enzyme genes of the CYP71AX subfamily from Helianthus annuus clustered in close proximity to one another on the sunflower genome. We show that one member of this subfamily, CYP71AX36, can catalyze the conversion of costunolide to 14-hydroxycostunolide. The catalytic activity of CYP71AX36 may be of use for the chemoenzymatic production of antileukemic 14-hydroxycostunolide derivatives and other STLs of pharmaceutical interest. We also describe the full 2D-NMR assignment of 14-hydroxycostunolide and provide all 13C chemical shifts of the carbon skeleton for the first time.
Expression Of Intracellular Components of the NF-κB Alternative Pathway (NF-κB2, RelB, NIK and Bcl3) is Associated With Clinical Outcome of NSCLC Patients
Authors: Dimitrakopoulos Foteinos-Ioannis D. , Antonacopoulou Anna G. , Kottorou Anastasia E. , Panagopoulos Nikolaos , Kalofonou Fotini , Sampsonas Fotios , Scopa Chrisoula , Kalofonou Melpomeni , Koutras Angelos , Makatsoris Thomas , Dougenis Dimitrios , Papadaki Helen , Brock Malcolm , Kalofonos Haralabos P. 
Published: October 2019

AbstractA growing number of studies has shed light on the role of the NF-κΒ in non-small-cell lung cancer (NSCLC). To address the significance of major effectors of the NF-κΒ alternative pathway, we investigated the relationship between NF-κΒ2, RelB, NIK and Bcl3 expression (mRNA and protein) and the clinical outcome of NSCLC patients. NF-κΒ2, RelB, NIK and Bcl3 protein expression levels were assessed by immunohistochemistry in tissue samples from 151 NSCLC patients who had curative resection. mRNA levels were also evaluated in 69 patients using quantitative real-time PCR. Although all studied proteins were overexpressed in NSCLC (P < 0.001 for all), only RelB mRNA levels were strongly increased in cancerous specimens compared to tumor-adjacent non-neoplastic tissues (P = 0.009). Moreover, NF-κB2, RelB and Bcl3 expression was associated with overall survival (OS). In particular, cytoplasmic and mRNA expression of RelB was related to 5-year OS (P = 0.014 and P = 0.006, respectively). Multivariate analysis also showed that Bcl3 expression (nuclear and cytoplasmic) was associated with increased 5-year OS (P = 0.002 and P = 0.036, respectively). In addition, higher Bcl3 mRNA levels were associated with inferior OS in stages I & II and improved OS in stages III and IV after 5-year follow-up (P = 0.004 and P = 0.001, respectively). Furthermore, stage I patients with lower NF-κB2 mRNA levels had better 5-year survival in univariate and multivariate analysis (P = 0.031 and P = 0.028, respectively). Interestingly, RelB expression (cytoplasmic and mRNA) was inversely associated with relapse rates (P = 0.027 and P = 0.015, respectively), while low NIK cytoplasmic expression was associated with lower relapse rates (P = 0.019). Cytoplasmic NIK expression as well as NF-κB2/ Bcl3 detection was associated with lymph node infiltration (P = 0.039 and P = 0.014, respectively). The present study confirms the deregulation of the NF-κB alternative pathway in NSCLC and also demonstrates the importance of this pathway in prognosis, recurrence and infiltration of regional lymph nodes.
Stability of selected reference genes in Sf9 cells treated with extrinsic apoptotic agents
Authors: Shu Benshui , Zhang Jingjing , Zeng Jie , Cui Gaofeng , Zhong Guohua 
Published: October 2019

AbstractAs a tightly controlled cell death process, apoptosis eliminates unwanted cells and plays a vital role in multicellular organisms. Previous study have demonstrated that apoptosis occurred in Spodoptera frugiperda cultured Sf9 cells, which triggered by diverse apoptotic stimuli, including azadirachtin, camptothecin and ultraviolet. Due to its simplicity, high sensitivity and reliable specificity, RT-qPCR has been used widespread for analyzing expression levels of target genes. However, the selection of reference genes influences the accuracy of results profoundly. In this study, eight genes were selected for analyses of their suitability as references for normalizing RT-PCR data in Sf9 cells treated with apoptotic agents. Five algorithms, including NormFinder, BestKeeper, Delta Ct method, geNorm, and RefFinder, were used for stability ranking. Based on comprehensively analysis, the expression stability of selected genes varied in cells with different apoptotic stimuli. The best choices for cells under different apoptosis conditions were listed: EF2 and EF1α for cells treated with azadirachtin; RPL13 and RPL3 for cells treated with camptothecin; EF1α and β-1-TUB for cells irradiated under ultraviolet; and EF1α and EF2 for combinational analyses of samples. Our results not only facilitate a more accurate normalization for RT-qPCR data, but also provide the reliable assurance for further studies of apoptotic mechanisms under different stimulus in Sf9 cells.
Temperature dependences of surface tension, density and viscosity study of Sn-Ag-Cu with Bi additions using theoretical models
Authors: M’chaar Rachida , Sabbar Abdelaziz , El Moudane Mouloud 
Published: October 2019

AbstractIn this work, the kohler, Muggianu,Toop and Hillert geometric models were used to calculate the surface tension, molar volume and density of the liquid Sn-Ag-Cu-Bi quaternary alloys along three selected sections xSn:xAg:xCu = 1:1:1, 1:1:2 and 1:2:1 in the temperature range of 923 K–1423 K. The choice of this temperature range was made on the basis of the calculation results of the liquidus line of the alloys belonging to the three sections. The same properties have been estimated for five selected Sn2.7Ag0.86Cu3.86Bi, Sn3.13Ag0.48Cu4.02Bi, Sn2.95Ag0.53Cu6.81Bi, Sn2.68Ag1.01Cu6.62Bi and Sn3.24Ag0.75Cu1.76Bi quaternary alloys between 623 K and 1123 K for comparison with the available experimental data. Moreover, the surface tension and density of these five alloys have also been calculated on the basis of Guggenheim and theoretical equation, respectively. In addition, the Seetharaman-sichen and Kaptay equations were extended to estimate the viscosity of SAC + Bi alloys. We also discussed the influence of Bismuth addition in liquid Sn-Ag-Cu-Bi. Estimated values show that Bi increases molar volume and density but decreases the surface tension and viscosity. On the other hand, the surface tensions diminish with the temperature for the all studied models, with the exception of some concentration of Bismuth; an inverse tendency is observed (dσ/dT) > 0. While, the density diminishes with increasing temperature for all alloys (dσ/dT) < 0. These models have been shown to be a great alternative for calculating the thermo-physical properties of quaternary systems.
Efficient production of large-size optical Schrödinger cat states
Authors: Mikheev Evgeny V. , Pugin Alexander S. , Kuts Dmitry A. , Podoshvedov Sergey A. , An Nguyen Ba 
Published: October 2019

AbstractWe present novel theory of effective realization of large-size optical Schrödinger cat states, which play an important role for quantum communication and quantum computation in the optical domain using laser sources. The treatment is based on the α-representation in infinite Hilbert space which is the decomposition of an arbitrary quantum state in terms of displaced number states characterized by the displacement amplitude α. We find analytical form of the α-representation for both even and odd Schrödinger cat states which is essential for their generation schemes. Two schemes are proposed for generating even/odd Schrödinger cat states of large size |β| (|β| ≥ 2) with high fidelity F (F ≈ 0.99). One scheme relies on an initially offline prepared two-mode entangled state with a fixed total photon number, while the other scheme uses separable photon Fock states as the input. In both schemes, generation of the desired states is heralded by the corresponding measurement outcomes. Conditions for obtaining states useful for quantum information processing are established and success probabilities for their generation are evaluated.
Mice deficient in the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) display a complex retinal phenotype
Authors: Atiskova Yevgeniya , Bartsch Susanne , Danyukova Tatyana , Becker Elke , Hagel Christian , Storch Stephan , Bartsch Udo 
Published: October 2019

AbstractNeuronal ceroid lipofuscinosis (NCL) type 1 (CLN1) is a neurodegenerative storage disorder caused by mutations in the gene encoding the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1). CLN1 patients suffer from brain atrophy, mental and motor retardation, seizures, and retinal degeneration ultimately resulting in blindness. Here, we performed an in-depth analysis of the retinal phenotype of a PPT1-deficient mouse, an animal model of this condition. Reactive astrogliosis and microgliosis were evident in mutant retinas prior to the onset of retinal cell loss. Progressive accumulation of storage material, a pronounced dysregulation of various lysosomal proteins, and accumulation of sequestosome/p62-positive aggregates in the inner nuclear layer also preceded retinal degeneration. At advanced stages of the disease, the mutant retina was characterized by a significant loss of ganglion cells, rod and cone photoreceptor cells, and rod and cone bipolar cells. Results demonstrate that PPT1 dysfunction results in early-onset pathological alterations in the mutant retina, followed by a progressive degeneration of various retinal cell types at relatively late stages of the disease. Data will serve as a reference for future work aimed at developing therapeutic strategies for the treatment of retinal degeneration in CLN1 disease.
Radio-enhancement effects by radiolabeled nanoparticles
Authors: Gholami Yaser Hadi , Maschmeyer Richard , Kuncic Zdenka 
Published: October 2019

AbstractIn cancer radiation therapy, dose enhancement by nanoparticles has to date been investigated only for external beam radiotherapy (EBRT). Here, we report on an in silico study of nanoparticle-enhanced radiation damage in the context of internal radionuclide therapy. We demonstrate the proof-of-principle that clinically relevant radiotherapeutic isotopes (i.e. 213Bi, 223Ra, 90Y, 177Lu, 67Cu, 64Cu and 89Zr) labeled to clinically relevant superparamagnetic iron oxide nanoparticles results in enhanced radiation damage effects localized to sub-micron scales. We find that radiation dose can be enhanced by up to 20%, vastly outperforming nanoparticle dose enhancement in conventional EBRT. Our results demonstrate that in addition to the favorable spectral characteristics of the isotopes and their proximity to the nanoparticles, clustering of the nanoparticles results in a nonlinear collective effect that amplifies nanoscale radiation damage effects by electron-mediated inter-nanoparticle interactions. In this way, optimal radio-enhancement is achieved when the inter-nanoparticle distance is less than the mean range of the secondary electrons. For the radioisotopes studied here, this corresponds to inter-nanoparticle distances <50 nm, with the strongest effects within 20 nm. The results of this study suggest that radiolabeled nanoparticles offer a novel and potentially highly effective platform for developing next-generation theranostic strategies for cancer medicine.
Female reproductive factors and risk of external causes of death among women: The Japan Public Health Center-based Prospective Study (JPHC Study)
Authors: Tanaka Shiori , Abe Sarah K. , Sawada Norie , Yamaji Taiki , Shimazu Taichi , Goto Atsushi , Iwasaki Motoki , Iso Hiroyasu , Mizoue Tetsuya , Inoue Manami , Tsugane Shoichiro 
Published: October 2019

AbstractAlthough empirical data suggest a possible link between female reproductive events and risk of nonfatal accidents and suicidal behaviors, evidence to determine these effects on mortality is scarce. This study investigated the association between female reproductive factors and the risk of external causes of death among middle-aged Japanese women. We used a population-based cohort study consisting of 71 698 women residing in 11 public health center areas across Japan between 1990 and 1994. Multivariable-adjusted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) of the risk of all external causes, suicide, and accidents according to female reproductive factors at the baseline survey. During 1 028 583 person-years of follow-up for 49 279 eligible subjects (average 20.9 years), we identified 328 deaths by all injuries. Among parous women, ever versus never breastfeeding [0.67 (95% CI: 0.49–0.92)] was associated with a decreased risk of all injuries. Risk of suicide was inversely associated with ever versus never parity [0.53 (95% CI: 0.32–0.88)]. A lower risk of death by accidents was seen in ever breastfeeding [0.63 (95% CI: 0.40–0.97)] compared to never breastfeeding. This study suggests that parity and breastfeeding are associated with reduced risk of death by all external causes, suicide and/or accidents among Japanese women.
Stellar populations of galaxies in the ALHAMBRA survey up to z ∼ 1
Authors: Díaz-García L. A. , Cenarro A. J. , López-Sanjuan C. , Peralta de Arriba L. , Ferreras I. , Cerviño M. , Márquez I. , Masegosa J. , del Olmo A. , Perea J. 
Published: October 2019

Aims. We perform a comprehensive study of the stellar population properties (formation epoch, age, metallicity, and extinction) of quiescent galaxies as a function of size and stellar mass to constrain the physical mechanism governing the stellar mass assembly and the likely evolutive scenarios that explain their growth in size.
Methods. After selecting all the quiescent galaxies from the ALHAMBRA survey by the dust-corrected stellar mass–colour diagram, we built a shared sample of ∼850 quiescent galaxies with reliable measurements of sizes from the HST. This sample is complete in stellar mass and luminosity, I ≤ 23. The stellar population properties were retrieved using the fitting code for spectral energy distributions called MUlti-Filter FITting for stellar population diagnostics (MUFFIT) with various sets of composite stellar population models. Age, formation epoch, metallicity, and extinction were studied on the stellar mass–size plane as function of size through a Monte Carlo approach. This accounted for uncertainties and degeneracy effects amongst stellar population properties.
Results. The stellar population properties of quiescent galaxies and their stellar mass and size since z ∼ 1 are correlated. At fixed stellar mass, the more compact the quiescent galaxy, the older and richer in metals it is (1 Gyr and 0.1 dex, respectively). In addition, more compact galaxies may present slight lower extinctions than their more extended counterparts at the same stellar mass (< 0.1 mag). By means of studying constant regions of stellar population properties across the stellar mass–size plane, we obtained empirical relations to constrain the physical mechanism that governs the stellar mass assembly of the form M⋆ ∝ rcα, where α amounts to 0.50–0.55 ± 0.09. There are indications that support the idea that the velocity dispersion is tightly correlated with the stellar content of galaxies. The mechanisms driving the evolution of stellar populations can therefore be partly linked to the dynamical properties of galaxies, along with their gravitational potential.
A cosmic collider: Was the IceCube neutrino generated in a precessing jet-jet interaction in TXS 0506+056?
Authors: Britzen S. , Fendt C. , Böttcher M. , Zajaček M. , Jaron F. , Pashchenko I. N. , Araudo A. , Karas V. , Kurtanidze O. 
Published: October 2019

Context. The neutrino event IceCube−170922A appears to originate from the BL Lac object TXS 0506+056. To understand the neutrino creation process and to localize the emission site, we studied the radio images of the jet at 15 GHz.Aims. Other BL Lac objects show properties similar to those of TXS 0506+056, such as multiwavelength variability or a curved jet. However, to date only TXS 0506+056 has been identified as neutrino emitter. The aim of this paper is to determine what makes the parsec-scale jet of TXS 0506+056 specific in this respect.Methods. We reanalyzed and remodeled 16 VLBA 15 GHz observations between 2009 and 2018. We thoroughly examined the jet kinematics and flux-density evolution of individual jet components during the time of enhanced neutrino activity between September 2014 and March 2015, and in particular before and after the neutrino event.Results. Our results suggest that the jet is very strongly curved and most likely observable under a special viewing angle of close to zero. We may observe the interaction between jet features that cross each other’s paths. We find subsequent flux-density flaring of six components passing the likely collision site. In addition, we find a strong indication for precession of the inner jet, and model a precession period of about 10 yr via the Lense-Thirring effect. We discuss an alternative scenario, which is the interpretation of observing the signature of two jets within TXS 0506+056, again hinting toward a collision of jetted material. We essentially suggest that the neutrino emission may result from the interaction of jetted material in combination with a special viewing angle and jet precession.Conclusions. We propose that the enhanced neutrino activity during the neutrino flare in 2014–2015 and the single EHE neutrino IceCube-170922A could have been generated by a cosmic collision within TXS 0506+056. Our findings seem capable of explaining the neutrino generation at the time of a low gamma-ray flux and also indicate that TXS 0506+056 might be an atypical blazar. It seems to be the first time that a potential collision of two jets on parsec scales has been reported and that the detection of a cosmic neutrino might be traced back to a cosmic jet-collision.