bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of restless legs syndrome plasmatic biomarkers by proteomic analysis
Authors: Bellei Elisa , Monari Emanuela , Ozben Serkan , Koseoglu Bitnel Mesrure , Topaloglu Tuac Selma , Tomasi Aldo , Bergamini Stefania 
Published: September 2018

AbstractObjectivesRestless legs syndrome (RLS) can lead to severe clinical consequences, thus negatively impacts on patients’ overall health and quality of life. Nevertheless, the pathophysiology of RLS is still unclear, resulting in underestimate, incorrect, or ignored diagnosis and in limited management and treatment. The aim of this study was to compare the plasma proteome of RLS patients and healthy controls, in the search of diagnostic biomarkers related to the disease severity.Materials and MethodsTwo‐dimensional gel electrophoresis coupled with liquid chromatography‐mass spectrometry was employed to analyze plasma samples of 34 patients with primary RLS, divided into two subgroups according to the disease severity: MMS group (mild‐moderate symptoms) and HS group (severe and very severe symptoms), and 17 age‐ and sex‐matched control subjects. Sleep quality, daytime sleepiness, and the level of depression were also evaluated.ResultsWe identified eight upregulated spots, corresponding to five unique proteins, in both RLS group vs. controls (alpha‐1B‐glycoprotein, alpha‐1‐acid glycoprotein 1, haptoglobin, complement C4‐A, and immunoglobulin kappa constant); five increased spots, consistent with three unique proteins, only in HS‐RLS (kininogen‐1, immunoglobulin heavy constant alpha 1, and immunoglobulin lambda constant 2); one downregulated spot in both patient's groups (complement C3) and another one only in HS‐RLS (alpha‐1‐antitrypsin).ConclusionsThe significantly different plasma proteins detected in RLS were mainly associated with inflammation, immune response, and cardiovascular disorders. Particularly, the gradual increasing in immunoglobulins could be indicative of the disease severity and evolution. Accordingly, these proteins may represent a valid set of useful biomarkers for RLS diagnosis, progression and treatment.
Can business‐oriented managers be effective leaders for corporate sustainability? A study of integrative and instrumental logics
Authors: Joseph Jay , Orlitzky Marc , Gurd Bruce , Borland Helen , Lindgreen Adam 
Published: September 2018

AbstractThis qualitative study investigates whether the views of managers need to be congruent with the corporate sustainability (CS) logics—either integrative or instrumental—of their employing organization. We assessed the CS performance of 25 organizations within the Australian forestry and wood products industry and analyzed the CS orientations of 32 senior managers within these companies to explore whether their individual CS views were consistent with organizational CS logics. The findings indicate that, in general, better performing organizations are led by managers that hold the integrative view, whereas poorer performing organizations are more likely to have managers with an instrumental view of CS. Nonetheless, there were noteworthy exceptions to this conclusion. The findings indicate that, under certain industry conditions, managers who hold an instrumental view may be able to generate ecological and social organizational outcomes that are at least equal to those produced by integrative managers.
Coronary bifurcation bench test using multimodality imaging: Impact of stent strut link location on stent deformity and jailed side‐branch orifices during re‐proximal optimizing technique
Authors: Kume Teruyoshi , Yamada Ryotaro , Koyama Terumasa , Tamada Tomoko , Imai Koichiro , Fukuhara Kenzo , Goryo Yutaka , Kawamura Ai , Okamoto Hiroshi , Neishi Yoji , Uemura Shiro 
Published: September 2018

AbstractObjectivesThe purpose of this study was to compare the stent deformation, obstruction of stent struts at a jailed side branch (SB) ostium, and stent strut malapposition after a repetitive proximal optimizing technique (re‐POT) sequence between bifurcation lesions with and without stent links at SB ostia in ex vivo experimental setting.MethodsA flexible urethane coronary bifurcation bench model was used, and crossover single stent implantation was performed from main branch (MB) with re‐POT sequence. Under videoscope observation, presence (link group, n = 12) or absence (no‐link group, n = 12) of stent link at distal semicircle of SB ostium was intentionally set, and rewiring was performed through distal cell in four different stent platforms.ResultsThere were no significant differences in the rate of malapposed struts and in SB jailing ratio after the re‐POT sequence between the link and no‐link groups. SB jailing ratio increased significantly from 8.0% to 9.6% during the second POT procedure (P < 0.001). SB jailing ratio after the second POT procedure differed among stent platforms.ConclusionsThe presence of a stent link at an SB ostium was not associated with a rate of malapposed struts and SB jailing ratio after the re‐POT sequence. SB jailing ratio was significantly increased after second POT procedure, but was different among stent platforms. The Xience stent might minimize the change of SB jailing ratio and be suitable for coronary bifurcation stenting using re‐POT sequence.
Twelve‐month outcomes of patients unsuitable for prolonged DAPT presenting with an acute coronary syndrome and treated with polymer‐free biolimus A9 drug‐coated stents
Authors: Kinnaird Tim , Abdul Fairoz , Hailan Ahmed , Sheikh Azeem , Hinton Jonathan , Yazji Khaled , Elangovan Senthil , Yousef Adnan , Gallagher Sean , Choudhury Anirban , Anderson Richard , O'Kane Peter , Smith David 
Published: September 2018

AbstractIntroductionProlonged dual anti‐platelet therapy (DAPT) is undesirable in certain patients. The biolimus‐A9 drug‐coated stent (BA9‐DCS) has a rapid drug‐elution profile allowing shortened DAPT.MethodsThe demographics, procedural data, and clinical outcomes for 505 patients presenting with an ACS to three UK centres and treated with a BA9‐DCS stent (PCI‐DCS) were collected, and compared to a consecutive ACS cohort of unselected patients treated in the same period with drug‐eluting stents (PCI‐DES).ResultsPCI‐DCS patients were older, more often female with hypertension, chronic kidney disease, severe LV dysfunction, and peripheral vascular disease more frequent than the PCI‐DES cohort. PCI‐DCS patients had a much higher Mehran bleed risk score (21.5 ± 7.7 vs. 15.9 ± 7.7, P < 0.0001). Baseline disease burden was greater in the PCI‐DCS cohort with more left main and three vessel disease. During PCI, more stents (1.91 ± 1.1 vs. 1.57 ± 0.94, P < 0.0001), total stent length (38.2 ± 20.8 vs. 31.4 ± 20.3, P < 0.0001) and longer stents (38.2 ± 20.8 vs. 31.4 ± 20.3 mm, P < 0.0001) were used in the PCI‐DCS cohort with rotational atherectomy also used more frequently. Physician‐recommended DAPT duration was 2.9 ± 3.9 months for PCI‐DCS patients and 11.3 ± 2.4 months for PCI‐DES patients (P < 0.0001). At 12‐month follow‐up, definite stent thrombosis (0.6% vs. 1.1%) and TLR (3.2% vs. 2.7%) rates were similar between the two groups. After adjustment for baseline differences, there were no statistically significant differences in death and combined MACE rates at 12 months.ConclusionsThe outcomes of patients treated with polymer‐free BA9 drug‐coated stent who present with an ACS and who were deemed unsuitable for prolonged DAPT are encouraging. Further studies are warranted.
Fracture in drug‐eluting stents increases focal intimal hyperplasia in the atherosclerosed rabbit iliac artery
Authors: Conway Claire , Desany Gerard J. , Bailey Lynn R. , Keating John H. , Baker Brian L. , Edelman Elazer R. 
Published: September 2018

AbstractObjectivesDrug‐eluting stent (DES) strut fracture (SF) is associated with higher incidence of In‐stent restenosis (ISR)—return of blockage in a diseased artery post stenting—than seen with bare metal stents (BMS). We hypothesize that concomitance of drug and SF leads to greater neointimal response.BackgroundControlled release of therapeutic agents, such as sirolimus and its analogs, or paclitaxel from has reduced tissue based DES failure modes compared to BMS. ISR is dramatically reduced and yet the implications of mechanical device failure is magnified.MethodsBilateral Xience Everolimus‐eluting stents (EES) were implanted in 20 New Zealand White rabbits on normal (n = 7) or high fat (HF)/high cholesterol (HC) (n = 13) diets. Implanted stents were intact or mechanically fractured. Everolimus concentration was as packaged or pre‐eluted. After 21 days, stented vessels were explanted, resin embedded, MicroCT scanned, and analyzed histomorphometrically.ResultsFractured EES were associated with significant (P < 0.05) increases in arterial stenosis and neointimal formation and lower lumen‐to‐artery area ratios compared to intact EES. Hyperlipidemic animals receiving pre‐eluted EES revealed no significant difference between intact and fracture groups.ConclusionsSF increases intimal hyperplasia, post EES implant, and worse with more advanced disease. Pre‐eluted groups, reflective of BMS, did not show significant differences, suggesting a synergistic effect of everolimus and mechanical injury, potentially explaining the lack of SF reports for BMS. Here, we report that ISR has a higher incidence with SF in EES, the clinical implication is that patients with SF after DES implantation merit careful follow‐up.
Autologous blood reinfusion during iatrogenic acute hemorrhagic cardiac tamponade: Safety and feasibility in a cohort of 30 patients
Authors: Fiocca Luigi , Cereda Alberto F. , Bernelli Chiara , Canova Paolo A. , Serino Federica , Niglio Tullio , Musumeci Giuseppe , Guagliumi Giulio , Vassileva Angelina , Senni Michele , Valsecchi Orazio 
Published: September 2018

AbstractBackgroundIatrogenic hemorrhagic pericardial tamponade (IHPT) represents a life‐threating condition requiring emergency pericardiocentesis. In this clinical context, reinfusion of pericardial blood can stabilize the patient and sustain hemodynamic conditions.Aims and MethodsWe reviewed all cases of IHPT occurred at our hospital over a 10 years span. In all patient autologous blood reinfusion through a femoral vein was performed.ResultsIn our clinical experience of 30 consecutive patients with hemorrhagic cardiac tamponade, this technique was successful to limit blood transfusions, to prevent further clinical worsening and bridge patients with intractable bleeding, to cardiac surgery. No major adverse reactions were directly related to blood autotransfusion.ConclusionIn the complex clinical scenario of acute tamponade occurring during catheter‐based cardiac procedures, autotransfusion of pericardial blood through a femoral vein is safe and effective. It can be a useful trick up the sleeve of the interventional cardiologist.
Open sesame technique in percutaneous coronary intervention for ST‐elevation myocardial infarction
Authors: Kimura Toshio , Nishibori Yoshiharu , Miki Kojiro , Maruyama Takao 
Published: September 2018

AbstractIn patients with ST‐elevation myocardial infarction (STEMI), delays in reperfusion attenuate the benefit of primary percutaneous coronary intervention (PCI) and associate with higher mortality rates. Although PCI operators are making their best effort in time saving for reperfusion, it is sometimes challenging and takes time to pass the guide wire across the target lesions. A totally occluded lesion in which a side branch was bifurcating at the proximal end of the occluded segment is one of the most technically challenging anatomies of the target lesion because it is difficult to identify the entry point of the occluded segment. A side branch technique, termed “Open Sesame Technique” (OST), has been previously introduced for chronic total occlusion (CTO) lesion in which a side branch was bifurcating at the proximal end of the occluded segment. We herein present two cases applying this technique in STEMI with totally occluded lesions at bifurcation as a culprit lesion, in which the entry point was not identified on the initial angiography. PCI were performed successfully using the OST in both cases, which resulted in saving procedural time and contrast volume without any complications. This technique can be effective not only in PCI for CTO lesions but also in primary PCI for STEMI cases with occluded bifurcation lesions.
Acute and long‐term outcomes after polytetrafluoroethylene or pericardium covered stenting for grade 3 coronary artery perforations: Insights from G3‐CAP registry
Authors: Pavani Marco , Cerrato Enrico , Latib Azeem , Ryan Nicola , Calcagno Simone , Rolfo Cristina , Ugo Fabrizio , Ielasi Alfonso , Escaned Javier , Tespili Maurizio , Conrotto Federico , Mancone Massimo , Colombo Antonio , Varbella Ferdinando 
Published: September 2018

AbstractBackgroundCovered stent (CS) implantation is considered a useful device in the setting of Grade III Coronary Perforation (G3CP), one of the most harmful PCI complication. However, data regarding efficacy of this device and clinical outcomes are still limited.Methods and resultsFrom 1993 to 2015, among 97,779 patients from 9 European centres undergoing PCI, 224 patients had G3CP (0.23%), and 102 patients were managed with CS implantation (96 with PTFE, 6 with pericardium). Device oriented composite endpoint (DOCE), a composite of cardiac death, target lesion revascularization, and stent thrombosis (ST) in‐hospital and at long term follow‐up were evaluated. G3‐CP perforations were successfully sealed with CS in 88 patients (86.3%) with need of intraprocedural pericardiocentesis in one‐third of cases. Protamine as heparin reversal agent was administered in 36 (35%) of cases. The cumulative incidence of in‐hospital DOCE were 16.6% (17/102): death 14.7%, TLR 2.9%, ST 3.9%. At long‐term follow‐up (mean 42 ± 38 months), DOCE rates occurred in 19.7%: death 7.4%, TLR 11%, and ST 6.2%. Indication to Dual Antiplatelet Therapy (DAPT) was lifelong in 20% of cases, 1 to 6 months in 22.5% and 12‐months in 57.5% without differences in long‐term DOCE before and after DAPT interruption (8.0 vs. 6.6%, respectively, P = 0.20).ConclusionsUse of CS was successful in sealing grade 3 coronary artery perforations in the majority of cases. Beside the high rate of clinical events at short and long‐term, ST remains the leading cause of device failure.
Day‐case percutaneous left atrial appendage occlusion—Safety and efficacy
Authors: Williams Timothy , Alsanjari Osama , Parker Jessica , Gannaway Alex , Thomson Catherine , Gomes Arionilson , Hildick‐Smith David 
Published: September 2018

AbstractObjectivesWe evaluated the safety and efficacy of percutaneous left atrial appendage (LAA) occlusion performed as a day case procedure.BackgroundLAA occlusion has been shown to be safe and effective for stroke prevention in patients with atrial fibrillation. It has not been shown if the procedure can safely be performed on a day‐case basis.MethodsRetrospective analysis was made of 117 LAA occlusion procedures in a single large teaching hospital in the UK. Procedural success, procedural complications, length of stay, and readmission data were examined.ResultsSuccessful deployment of a device was possible in all but one patient (whose appendage was too large). Major in‐hospital complications occurred in 1.7% of patients (both femoral vascular). Same‐day discharge was made in 66% of patients overall. Since January 2016, only 3 of 59 patients (5%) have remained in hospital overnight following LAAO. Echocardiography 2–4 hr postprocedure was undertaken prior to discharge. One patient was readmitted within 7 days but this readmission would not have been prevented by overnight stay.ConclusionsLAA occlusion can be safely performed as a day case procedure with acceptable complication rates and no increment of complications related to the lack of routine overnight stay.
Left atrial hemodynamics and left ventricular remodeling –predictors of outcomes after Transcatheter mitral valve repair with the MitraClip device
Authors: Lazkani Mohamad , Sawant Abhishek C. , Taase Alicia , Khan Sahoor , Fang Kenith , Iyer Vijay , Pershad Ashish 
Published: September 2018

AbstractBackgroundIncreased afterload and reduced left ventricular (LV) performance are sequela of mitral valve repair. However, hemodynamic left atrial and ventricular parameters that can predict outcome following mitral valve repair remain elusive.MethodsOne hundred and two consecutive patients undergoing MitraClip procedure from 2014 to 2017 at Banner University Medical Center were enrolled in this study. All patients underwent pre‐procedure echocardiograms and intra‐procedure invasive left atrial (LA) pressure monitoring. Clinical, laboratory, and procedural parameters were collected. The primary end‐point was the composite outcome of all‐cause mortality and repeat hospitalization within 90 days.ResultsThe mean age was 77 ±10 years, the majority were Caucasians (93, 91.2%) and 47 (46.1%) were males. Thirty‐two patients (31.4%) had diabetes, 39 (38.2%) had renal insufficiency, and 38 (37.3%) had a history of congestive heart failure. The median society of thoracic surgeons score was 6.7% (Interquartile range [IQR]: 3.9, 10.2). Immediately post‐procedure there was a significant reduction in the LA pressure (Mean 12.0 vs. 18.6 mmHg, P < 0.001) and pulmonary artery systolic pressure (43.5 vs. 53.2 mmHg, P = 0.001) compared to baseline. LA pressure was an independent predictor of the composite outcome in an unadjusted (OR = 1.07, 95% CI: 1.00–1.13, P = 0.03) and adjusted (OR = 1.07, 95% CI: 1.00–1.14, P = 0.03) analysis respectively.ConclusionLA pressure drop is an independent predictor of outcome after the MitraClip procedure. This finding has implications for early identification of patients at risk of poor outcomes and instituting aggressive medical therapy and close follow‐up for avoiding hospitalizations for heart failure decompensation.
Glycoprotein IIb/IIIa inhibitor use in patients with acute myocardial infarction undergoing PCI: Insights from the TRANSLATE ACS study
Authors: Ibrahim Homam , Kaltenbach Lisa A. , Hess Connie N. , Recchia Tammy , Effron Mark B. , Stone Gregg W. , Wang Tracy Y. 
Published: September 2018

AbstractIntroductionConcomitant use of glycoprotein IIb/IIIa inhibitors (GPI) and P2Y12 inhibitors increases bleeding risk. How GPIs are being used with faster onset, higher potency P2Y12 inhibitors are unclear.Methods and resultsWe studied 11,781 myocardial infarction (MI) patients treated with percutaneous coronary intervention (PCI) at 233 hospitals in the TRANSLATE ACS study (2010–2012). We used propensity matching to compare 6‐week major adverse cardiac events (MACE: death, recurrent MI, stroke, or unplanned revascularization) and BARC 2+ bleeding events between patients who did and did not receive planned GPI.Planned and bailout GPI were used in 4,983 (42.2%) and 229 (4.4%) MI patients undergoing PCI, respectively. Patients receiving planned GPI were younger (58 vs. 61 years), more likely to present with STEMI (62.6% vs. 45.4%) or have stent thrombosis (4.2% vs. 2.1%, all P < 0.001) than those without planned GPI use. Planned GPI was used less often with prasugrel/ticagrelor versus clopidogrel (37.1% vs. 43.3%), or when any P2Y12 inhibitor was given >6 hr prior to PCI versus earlier (27.8% vs. 44.4%, both P < 0.01). After propensity matching, planned GPI use was not associated with any difference in MACE (6.4% vs. 5.5% OR 1.18; 95% CI: 0.99–1.57), however, the risk of BARC 2+ bleeding was higher in patients who received planned GPI (11.3% vs. 8.7%; OR 1.34; 95% CI: 1.13–1.59).ConclusionPlanned GPI use as reported by practicing physicians was prevalent between 2010 and 2012 and was associated with increased risk of bleeding but not lower MACE.
Impact of left atrial compliance improvement on functional status after percutaneous mitral valvuloplasty
Authors: Athayde Guilherme Rafael Sant'Anna , Nascimento Bruno Ramos , Elmariah Sammy , Lodi‐Junqueira Lucas , Soares Juliana Rodrigues , Saad Gabriel Prado , da Silva Jose Luiz Padilha , Tan Timothy C. , Hung Judy , Palacios Igor F. , Levine Robert A. , Nunes Maria Carmo Pereira 
Published: September 2018

BackgroundConventional hemodynamic parameters may not accurately predict symptomatic improvement after percutaneous mitral valvuloplasty (PMV). Changes in left heart chamber compliance following adequate relief o0066 mitral stenosis (MS) may be useful in determining functional capacity after PMV. This study aims to determine the acute effects of PMV on compliance of the left heart and whether its changes relate to the patient's functional capacity.MethodsOne‐hundred thirty‐seven patients with severe MS undergoing PMV were enrolled. Left atrial (Ca) and left ventricular (Cv) compliance were invasively estimated and net atrioventricular compliance (Cav) was calculated before and immediately after the procedure. B‐type natriuretic peptide (BNP) levels were obtained before and 24 hr after the procedure. The primary endpoint was functional status at 6‐month follow‐up, and the secondary endpoint was a composite of death, mitral valve (MV) replacement, repeat PMV, new onset of atrial fibrillation, or stroke in patients in whom PMV was successful.ResultsThe mean age was 43 ± 12 years, and 119 patients were female (87%). After PMV, Ca and Cav improved significantly from 5.3 [IQR 3.2–8.2] mL/mmHg to 8.7 [5.3–19.2] mL/mmHg (P < 0.001) and 2.2 [1.6–3.4] to 2.8 [2.1–4.1] mL/mmHg (P < 0.001), respectively, whereas Cv did not change (4.6 [3.2–6.8] to 4.4 [3.1–5.6]; P = 0.637). Plasma BNP levels significantly decreased after PMV, with no correlation between its variation and changes in left chamber compliance. At 6‐month follow‐up, NYHA functional class remained unchanged in 32 patients (23%). By multivariable analyses, changes in Ca immediately after PMV (adjusted OR 1.42; 95% CI 95% 1.02 to 1.97; P = 0.037) and younger age (adjusted OR 0.95; CI 95% 0.92–0.98; P = 0.004), predicted improvement in functional capacity at 6‐month follow‐up, independent of postprocedural data. The secondary endpoint were predicted by post‐PMV mean gradient (adjusted HR 1.363; 95% CI 95% 1.027–1.809; P = 0.032), and lack of functional improvement at 6‐month follow‐up (adjusted HR 4.959; 95% 1.708–14.403; P = 0.003).Conclusions
Ca and Cav increase significantly after PMV with no change in Cv. The improvement of Ca is an important predictor of functional status at 6‐month follow up, independently of other hemodynamic data. Postprocedural mean gradient and lack of short‐term symptomatic improvement were predictors of adverse outcome.
Valvuloplasty balloon entrapment in a self‐expanding aortic valve stent frame after inadvertent wire passage through the outflow struts
Authors: Piayda Kerstin , Hellhammer Katharina , Veulemans Verena , Zeus Tobias 
Published: September 2018

AbstractTranscatheter aortic valve replacement (TAVR) is a leading‐edge therapy option for patients with severe aortic stenosis (AS) and high surgical risk. However, this minimally invasive procedure is associated with specific complications that may be life‐threatening. Valvuloplasty balloon entrapment during postdilatation in transcatheter self‐expanding aortic valve stent frames has not yet been a focus of interest in this context. Although it is a rare event, it may critically influence outcome, and different management strategies can be considered. Hereafter, we present the case of a 67‐year‐old male who underwent transfemoral TAVR and subsequent postdilatation. The valvuloplasty balloon was entrapped in the self‐expanding aortic valve stent frame after inadvertent wire passage through the outflow struts. Since surgical risk was high, we preferred a percutaneous approach and extracted the entrapped balloon with high traction force under rapid pacing after valve stabilization with another balloon, which was placed in the annular position.