bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coagulant Activity Deposited on the Kiil Haemodialysis Membranes
Authors: Lurie A , Denson K. W. E 
Published: June 2018

SummaryA deposit present on the dialysing membranes of Kiil renal dialysis machines after extracorporeal haemodialysis has been found to have coagulant activity with features similar to phospholipid and to the thromboplastic activity of platelets. The deposition of the coagulant material occurred in spite of anti-coagulation with heparin. It is postulated that this coagulant material may render the extracorporeal blood hypercoagulable, and that this may be of significance in the pathogenesis of thrombosis in the shunt vasculature.
Thrombozytenausbreitungstest im Elektronenmikroskop
Authors: Ruzicka F , Fierkens D 
Published: June 2018

ZusammenfassungMittels dem modifizierten Thrombozytenausbreitungstest nach Marx, Ibrom und Stanislawski wurden lichtmikroskopische Präparate von 20 gesunden Versuchspersonen untersucht. Bis auf die Gruppe der Spinnen- und der kleinen Ausbreitungs-formen stimmen unsere Resultate mit den in der Literatur angegebenen überein.Die ausgebreiteten Thrombozyten wurden nach Schrägbedampfung mittels zweier Methoden untersucht, wobei die eine die Oberflächenstrukturen, die andere die komplette Zelle erfaßte. Aufgrund der Ergebnisse wird für die elektronenoptische Auswertung eine neue Einteilung angegeben. Danach werden die Typen A1, A2 der vollständig ausgebreiteten, die Gruppe C der nicht ausgebreiteten Thrombozyten und die Gruppe D der Formen mit netzartiger Oberfläche unterschieden.
Large-Scale Production of Intermediate-Purity, Soluble Human Plasminogen
Authors: Bergström K , Tse Ann O. , Johnson A. J 
Published: June 2018

SummaryA method is described for laboratory, pilot or large-scale production of intermediatepurity human plasminogen soluble at neutral pH, with a specific proteolytic activity of approximately 12.5 CTA units/mg protein. Batches of 100-200 g can be readily produced from Fraction III paste from outdated or fresh-frozen plasma. Since this plasminogen is stable on long-term storage, and low in spontaneous plasmin activity, it is especially useful as an assay reagent (substrate) and as starting material for the preparation of high-purity plasminogen.
Inhibition of Tissue Activator by Urokinase Inhibitor
Authors: Kawano T , Uemura Y 
Published: June 2018

SummaryInhibition of tissue activator purified from human heart by urokinase inhibitor purified from human placenta was observed by both the fibrin plate method and fibrin clot lysis time method. It was shown to be of much less on extent in comparison with urokinase, that is, 20 Ploug units of urokinase were completely inhibited by approximately 100 or 200 u of urokinase inhibitor in the respective methods but 6 Ploug units of tissue activator were inhibited only 25% to 50% even though 1,000 u of urokinase inhibitor were used.
The Effect of Intravascular and Extravascular Coagulation on Serum Fibrin Degradation Products in Rats
Authors: Van Stone J. C , Khoury N. Y 
Published: June 2018

SummarySerum fibrin degradation products (FDP) were elevated following intravascular clotting in rats. The levels of these products were similar whether the blood clot remained localized in the inferior vena cava or embolized to the lung. The level of FDP increased with increasing amounts of blood clot formed. The intravascular injection of 100 u of thrombin induced high levels of FDP and resulted in death of the animals. Extravascular deposition of fibrin, either subcutaneously, intramuscularly or intraperitoneally had no effect on serum FDP.
Adenine Nucleotide Metabolism of Human Platelets
Authors: Murakami M , Odake K 
Published: June 2018

SummaryAfter platelet-rich plasma was incubated with radioactive adenine, radioactive adenine nucleotides in platelets were separated by two-dimensional thin-layer chromatography.Radioactive adenine was selectively incorporated into adenine nucleotides. Gradual decomposition of labelled nucleotides was observed after longer period of incubation. Radioactive ATP, ADP, AMP, IMP, and hypoxanthine were separated from PCA extract of platelets. On the other hand, radioactive adenine and hypoxanthine were separated from platelet-poor plasma.After thrombin treatment, radioactive ATP in platelets broke down rapidly, while radioactive ADP decreased more slowly. Radioactive AMP increased at first in the cellular and supernatant fractions, and then decreased gradually. The accumulation of radioactive hypoxanthine was observed in the supernatant fraction. Released radioactive ATP and ADP were 23% and 22% of the initial radioactive ATP and ADP in platelets, respectively.
Inhibition of Coagulation and Fibrinolysis by Aromatic Amidino Compounds
Authors: Geratz J.D 
Published: June 2018

Summary1. Aromatic diamidines which are potent inhibitors of trypsin possess a marked inhibitory effect on the clotting activity of human thrombin and on the prothrombin time and partial thromboplastin time of human plasma. They also block the contact activation phase of the coagulation process. The strongest inhibitor among the compounds tested was M & B 4596 which was followed in second place by pentamidine.2. Pentamidine was 10 times more active than ε-ACA in impeding streptokinase-induced lysis of human plasma clots. It was 100-200 times stronger than ε-ACA in inhibiting the activation of bovine plasminogen by activators formed from the interaction between streptokinase and either human plasmin(ogen) or human plasma.3. The prothrombin time and partial thromboplastin time of canine plasma were less susceptible to inhibition by pentamidine than the same tests on human plasma. Clot lysis in the canine system was inhibited by pentamidine to a similar degree as in the human system. After intravenous injection of pentamidine in the dog there occurred the expected prolongation of the partial thromboplastin time and of the clot lysis time.
Congenital Afibrinogenemia
Authors: Girolami A , Zacchello G , D’Elia R 
Published: June 2018

SummaryA case of congenital afibrinogenemia is reported.The patient is a 2 month old white female infant who presented bleeding from the umbilical stump a few days after birth. Subsequently other hemorrhagic manifestations were hematomas at the site of venipunctures.All routine plasmatic tests gave values greater than 1000 sec. The prothrombin time was corrected by the addition of equal parts of plasma of all known prothrombin complex factor deficiences. No fibrinogen was found in the patient’s plasma. The immunological assay of fibrinogen confirmed the lack of this protein in the proposita’s plasma thereby excluding a dysfibrinogenemia. The father and the mother of our proposita were found to have slightly reduced fibrinogen levels and were considered to be heterozygotes for the abnormality. Four other relatives were thougth to be heterozygotes for the abnormality.The hereditary trasmission of the disorder appears to be autosomal incompletely recessive.
Aggregation of Platelets Remaining in Circulation after Acute Thrombosis
Authors: Zbinden G , Grimm L , Muheim M 
Published: June 2018

SummaryI.v. injection of ADP and Na laurate in guinea pigs caused acute platelet sequestration and occasional formation of fresh platelet thrombi in the lungs. ADP-induced aggregation of platelets isolated after the injection was found to be consistently reduced. No difference in platelet response to ADP was found when PRP obtained before and after treatment with Evans blue was compared. It was concluded that ADP- and Na laurate-induced thrombosis eliminated preferentially the ADP-responsive platelet fraction whereas the effect of Evans blue was not dependent on the functional state of the platelets.
Simplifying Homeopathy
Authors: Vervarcke Anne 
Published: June 2018

AbstractAfter the initial enthusiasm in the homeopathic community about the exciting progress and expansion since the 1980s, the sobering fact seems to be that we evolved in the direction of such sophistication that our dear system becomes unmanageable. We did our inner work, try to balance things that were somehow off but still the plain fact is that we are still crushed under too much information. And there is no way to stop it! We are only at the beginning of exploring and including every single species on the planet and beyond in our Materia Medica. But we've already come to a point where even the fastest and most extensive software programs won't help us solve a case. In this article, I argue that we need to boil down the overwhelming bulk of data to clear, simple and reliable pointers to large groups and then smaller groups. The best way to do this is adding the ‘context’ in the analysis. Though often overlooked it turns out to be solid information. The first distinction in a case analysis could be between the Second Dimension (Rocks and Stones, Gems, Bacteria, Viruses, Sarcodes) and the Third Dimension groups (Plants, Animal and Fungi) and often the context will decide. Some information on these groups is given, in an attempt to make homeopathy manageable again without losing its refinement.
Successful Surgical Abdominal Aortic Debranching Preceding Stent Graft Implantation: A Case Report
Authors: Laux Magdalena , Erb Michael , Hoelschermann Frank , Albes Johannes 
Published: June 2018

Background Acute endovascular aneurysm repair with stent grafts (thoracic endovascular aortic repair [TEVAR]) is safe and feasible.
Case Description A 64-year-old female presented with a perforated aortic aneurysm of the thoracic descending aorta. Primary TEVAR resulted in good management of the perforation but a type Ib endoleakage remained postoperatively. To place another stent, abdominal debranching with saphenous vein bypass to the celiac trunk was required. In the same session, another endograft was inserted successfully.
Conclusion Abdominal debranching is a safe alternative to open aortic repair in acute thoracic and abdominal aneurysms, instead of waiting for a custom-made device.
Orthogeriatrie
Authors: Liener Ulrich , Peters Kerstin , Hartwig Erich , Hoffmann Reinhard , Bücking Benjamin 
Published: June 2018

ZusammenfassungDie Anzahl osteoporotischer Frakturen und multimorbider Patienten ist in den letzten Jahren angestiegen und wird weiter steigen. Aufgrund der substanziellen Morbidität und Mortalität von Fragilitätsfrakturen bei diesen Patienten hat inzwischen ein Paradigmenwechsel – weg von der Sichtweise einer unfallchirurgischen Monoverletzung, hin zu der Sichtweise eines orthogeriatrischen Syndroms – stattgefunden. Neben der Frakturversorgung beinhaltet dieses Konzept auch eine medikamentöse Therapie der Osteoporose.
See/Witnessand the ‘setting-subject construction’
Authors: Lacassain-Lagoin Christelle 
Published: June 2018

AbstractPerception verbs prototypically occur with a grammatical subject NP referring to a person. However,seeandwitnessalso license an inanimate grammatical subject, more precisely a spatial or temporal setting, in a “setting-subject construction” (Langacker 1991,2008). The present study addresses this kind of variation, and demonstrates how the two alternate constructions reveal shifts from an egocentric perspective to an anthropocentric perspective. It sets out to accomplish three main goals: first, to establish whether each construction aligns perfectly with one particular perspective; second, to identify the semantic and syntactic characteristics of setting-subject constructions and explain how an inanimate subject NP can be favored over a human subject NP; third, to determine what can motivate speakers’ choices between the two alternate constructions licensed byseeandwitness. To achieve this, a qualitative, corpus-based analysis is carried out, which helps to understand to what extent the grammatical coding embodies a specific way of viewing the scene. First, the cognitive theoretical concepts (e.g., the Extended Animacy Hierarchy (Croft, 2003), egocentric and canonical viewing arrangements, cognitive schemas and models) that are helpful for the proper characterization of the two structures are presented, as well as the methodology employed to collect data for the present study. I then focus on prototypical, human subject NP constructions which reveal either an egocentric or an anthropocentric point of view of the scene. Finally, setting-subject constructions are addressed: not only are the characteristics of such structures highlighted but also the parameters and factors that contribute to their occurrence are identified. The study shows that such constructions convey the conceptualizer’s assessment of a situation, as the viewing relationship is construed subjectively. A setting-subject construction thus reveals a perspective that indirectly turns out to be more anthropocentric than ‘setting-centric’, as the inanimate locative subject, ranking at the bottom of the Animacy hierarchy, winds up alluding to any possible human being, including the speaker, the addressee and the Other.
Introduction
Authors: Pym Anthony 
Published: June 2018

Abstract
Mediation strategies are deployed when people use translation, interpreting, lingua francas, intercomprehension, language learning, or any combination of these to communicate in situations where there is more than one language in play. Such choices can be seen as enacting trade-offs between the goals of mobility (across geolinguistic borders) and inclusion (primarily into labor markets and government services). Mediation strategies are nevertheless selected in accordance with complex sets of criteria by which they are evaluated and compared in each particular situation. Case studies suggest that, if seen as performative language policy, the strategies tend to give more priority to social inclusion than to language diversity. They might thus constitute a challenge to some approaches to official language policy.
“Do I want to learn a language spoken by two million people?”
Authors: Pokorn Nike K. , Čibej Jaka 
Published: June 2018

Abstract
Migrants’ intended length of stay influences their choices between using a lingua franca, language technology, ad-hoc interpreters and translators, intercomprehension, or learning the host country’s dominant language. To study this influence, data were collected through a questionnaire, semi-structured interviews, and a focus-group discussion from 15 long-term migrants (university language teachers) and eight mid-term migrants (teachers at two international schools) working in Slovenia. The results show that the long-term migrants all learned the host language, while the most common mediation strategy of the mid-term migrants was use of a lingua franca. Ad-hoc interpreters and translators were used not only in healthcare but also for the translations of official documents. Moreover, the French-speaking mid-term migrants attempted to learn the host language and often ended up learning English, while the group of native English speakers tended to form a linguistic enclave. It is argued that the preferred mediation strategy depends not just on the intended length of stay but also on the status of the migrant’s L1 in the particular host country.
The complementary nature of linguistic mediation in transnational adoption mobility
Authors: Fiorentino Alice 
Published: June 2018

Abstract
In order to explore why people in multilingual contexts choose one mediation strategy or another, we conducted case studies involving short-term mobility for adoption purposes. For parents who adopt a child born in a different country, the experience necessitates a range of linguistic strategies that include language learning, interpreting and translation services, lingua francas, and intercomprehension. A study of ten Italian transnational adoptive families shows that adoptive parents tend to combine these strategies according to the situational relevance of four mobility-related variables: parental agency, accuracy of information, self-reliance, and intimacy. The adoptive parents’ opinions about the benefits and limitations of each strategy indicate that mediation strategies are complementary means to reach the complex general purpose of acquiring parenthood.
Breathing life into social presence
Authors: Fester Marie-Theres , Cowley Stephen J. 
Published: June 2018

AbstractWhilst many studies focus on human-to-media interactions, this paper turns to how a multimodal medium contributes to human-to-human interaction. By bringing together both radical embodied cognitive science (Chemero 2009) and dialogism (Linell 2009), the paper develops an anti-representationalist approach to the concept of social presence. We use an exploratory study of close friendships that maintain their interaction through the use of the mobile instant messaging service WhatsApp. In so doing, we describe texting as language-activity where people engage with each other by using resources from body, environment, and brain. Our work represents a major departure from previous studies of mobile interaction in adopting an embodied view of language and cognition. By so doing, we show how parties create anticipatory routines that enable them to ‘hear’ and ‘see’ their interlocutor. The paper’s main contribution is to draw attention to this kind of heightened social presence that we choose to call “co-imagining”.
Language, attitudes and party politics
Authors: Feng Dezheng (William) , Zhang Shuo 
Published: June 2018

AbstractThis study investigates Barack Obama’s attitudes towards Republicans and Democrats by analyzing a corpus of 249 Presidential weekly addresses. Analysis shows that Obama’s attitudes towards the Republicans are characterized by a negative judgment of propriety, creating a negative image of the Republican Party, whereas when Republicans and Democrats are mentioned together, his attitudes are characterized by his hopes for and commendations on bipartisan collaboration. An analytical model based on the attitude schema is proposed to explicate the strategies for encoding attitudes. It is found that negative attitudes are always expressed implicitly by recounting events that elicit the attitudes (i.e. behaviors of the Republicans) and performing speech acts that are motivated by the attitudes (i.e. urging the Republicans to stop the wrong behaviors). The patterns of attitudes reflect bipartisan conflict and cooperation on the one hand, and constitute an important strategy to battle against the opposition party and build coalitions on the other.
Why did Trump say “I hope you will let Flynn go” to Comey?
Authors: Capone Alessandro , Bucca Antonino 
Published: June 2018

Abstract
In this paper, we analyse and discuss an utterance/pragmeme/pract proffered by US President Donald Trump and addressed to FBI Director Comey: ‘I hope you will let Flynn go’.1 We consider the explicature of this utterance (‘I hope you will drop the Russian investigation concerning Flynn’) and its illocutionary and perlocutionary effects. We argue that while Republicans opt for an Austinian or Searlean analysis, in the attempt to deny that this utterance constituted an attempt to influence Comey, there are reasons for adopting a Strawsonian analysis, casting it in the framework of pragmemes, devised by Mey (2001), that frame a socio-pragmatic analysis of utterance interpretation within context. This analysis shows, Trump illicitly tried to persuade Comey to drop the Russian investigation, and therefore attempted to interfere with the judiciary system. A reasoned case can be made for saying that Trump had the intention of interfering with America’s federal court system through this utterance.
Orthostatic Hypotension in the Hypertensive Patient
Authors: Biaggioni Italo 
Published: June 2018

Abstract
Orthostatic hypotension (OH) is an important and common medical problem, particularly in the frail elderly with multiple comorbidities and polypharmacy. OH is an independent risk factor for falls and overall mortality. Hypertension is among the most common comorbidities associated with OH, and its presence complicates the management of these patients because treatment of one can worsen the other. However, there is evidence that uncontrolled hypertension worsens OH so that both should be managed. The limited data available suggest that angiotensin receptor blockers and calcium channel blockers are preferable antihypertensives for these patients. Patients with isolated supine hypertension can be treated with bedtime doses of short-acting antihypertensives. Treatment of OH in the hypertensive patients should focus foremost on the removal of drugs that can worsen OH, including ones that are easily overlooked, such as tamsulosin, tizanidine, sildenafil, trazodone, and carvedilol. OH and postprandial hypotension can be prevented with abdominal binders and acarbose, respectively, without the need to increase baseline blood pressure. Upright blood pressure can be improved by harnessing residual sympathetic tone with atomoxetine, which blocks norepinephrine reuptake in nerve terminals, and pyridostigmine, which facilitates cholinergic neurotransmission in autonomic ganglia. Oral water bolus acutely but transiently increases blood pressure in autonomic failure patients. If traditional pressor agents are needed, midodrine and droxidopa can be used, administered at the lowest dose and frequency that improves symptoms. Management of OH in the hypertensive patient is challenging, but a management strategy based on understanding the underlying pathophysiology can be effective in most patients.
Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy
Authors: Ghaemi Mohammad Sajjad , DiGiulio Daniel B , Contrepois Kévin , Callahan Benjamin , Ngo Thuy T M , Lee-McMullen Brittany , Lehallier Benoit , Robaczewska Anna , Mcilwain David , Rosenberg-Hasson Yael , Wong Ronald J , Quaintance Cecele , Culos Anthony , Stanley Natalie , Tanada Athena , Tsai Amy , Gaudilliere Dyani , Ganio Edward , Han Xiaoyuan , Ando Kazuo , McNeil Leslie , Tingle Martha , Wise Paul , Maric Ivana , Sirota Marina , Wyss-Coray Tony , Winn Virginia D , Druzin Maurice L , Gibbs Ronald , Darmstadt Gary L , Lewis David B , Partovi Nia Vahid , Agard Bruno , Tibshirani Robert , Nolan Garry , Snyder Michael P , Relman David A , Quake Stephen R , Shaw Gary M , Stevenson David K , Angst Martin S , Gaudilliere Brice , Aghaeepour Nima 
Published: June 2018

AbstractMotivationMultiple biological clocks govern a healthy pregnancy. These biological mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations during the course of pregnancy. Modeling the chronology of these adaptations during full-term pregnancy provides the frameworks for future studies examining deviations implicated in pregnancy-related pathologies including preterm birth and preeclampsia.ResultsWe performed a multiomics analysis of 51 samples from 17 pregnant women, delivering at term. The datasets included measurements from the immunome, transcriptome, microbiome, proteome and metabolome of samples obtained simultaneously from the same patients. Multivariate predictive modeling using the Elastic Net (EN) algorithm was used to measure the ability of each dataset to predict gestational age. Using stacked generalization, these datasets were combined into a single model. This model not only significantly increased predictive power by combining all datasets, but also revealed novel interactions between different biological modalities. Future work includes expansion of the cohort to preterm-enriched populations and in vivo analysis of immune-modulating interventions based on the mechanisms identified.Availability and implementationDatasets and scripts for reproduction of results are available through: https://nalab.stanford.edu/multiomics-pregnancy/.Supplementary informationSupplementary data are available at Bioinformatics online.