bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development and external validation of simplified T category classification for nasopharyngeal carcinoma to improve the prognostic value in the intensity‐modulated radiotherapy era
Authors: Tang Ling‐Long , Liang Shao‐Bo , Huang Cheng‐Long , Zhang Fan , Xu Cheng , Mao Yan‐Ping , Tian Li , Lin Ai‐Hua , Li Li , Sun Ying , Ma Jun 
Published: April 2019

AbstractBackgroundIntensity‐modulated radiotherapy (IMRT) provides excellent local control in nasopharyngeal carcinoma (NPC). We investigated whether simplifying 8th American Joint Committee on Cancer staging system T categories improves prognostic value.MethodsWe used 2191 NPC patients as a training set and 414 patients separately as an independent, external validation cohort.ResultsIn the training set, local relapse‐free survival (LRFS), disease‐free survival (DFS), and overall survival (OS) were not significantly different between the 8th edition T2/T3 (P = 0.610, 0.380 and 0.353, respectively). Merging T2 and T3 to proposed T2 (proT2) provided significant differences in LRFS, DFS, and OS between proposed T categories. Proposed T categories had similar c‐indices for LRFS, DFS, and OS (vs the 8th edition), which was validated in the external cohorts. Moreover, for DFS, the adjusted HRs of the proT2N0 (3.8), proT1N1 (3.8), and proT2N1 (6.0) subsets were similar; the adjusted HRs of the proT3N0 (7.0), proT3N1 (11.4), proT1N2 (11.0), proT2N2 (11.6), and proT3N2 (13.3) subsets were similar; the adjusted HRs of the proT1N3 (17.8), proT2N3 (15.3), and proT3N3 (26.4) subsets were similar; the results of the adjusted HRs for OS had the same rule. Defining proT1N0 as stage I; proT1N1/proT2N0‐1 as stage II; proT3N0‐2/proT1‐2N2 as stage III; and proT1‐3N3 as stage IVa generated orderly, significant differences in DFS and OS between stages in the training set and external validation cohort.ConclusionsIn the IMRT era, three T categories are more reasonable (merging T2/T3 into T2) and proT3N0‐2 (the 8th edition T4N0‐2) should be down‐staged to stage III.
The dyslexia susceptibility KIAA0319 gene shows a specific expression pattern during zebrafish development supporting a role beyond neuronal migration
Authors: Gostic Monika , Martinelli Angela , Tucker Carl , Yang Zhengyi , Gasparoli Federico , Ewart Jade‐Yi , Dholakia Kishan , Sillar Keith T. , Tello Javier A. , Paracchini Silvia 
Published: April 2019

AbstractDyslexia is a common neurodevelopmental disorder caused by a significant genetic component. The KIAA0319 gene is one of the most robust dyslexia susceptibility factors but its function remains poorly understood. Initial RNA‐interference studies in rats suggested a role in neuronal migration whereas subsequent work with double knock‐out mouse models for both Kiaa0319 and its paralogue Kiaa0319‐like reported effects in the auditory system but not in neuronal migration. To further understand the role of KIAA0319 during neurodevelopment, we carried out an expression study of its zebrafish orthologue at different embryonic stages. We used different approaches including RNAscope in situ hybridization combined with light‐sheet microscopy. The results show particularly high expression during the first few hours of development. Later, expression becomes localized in well‐defined structures. In addition to high expression in the brain, we report for the first time expression in the eyes and the notochord. Surprisingly, kiaa0319‐like, which generally shows a similar expression pattern to kiaa0319, was not expressed in the notochord suggesting a distinct role for kiaa0319 in this structure. This observation was supported by the identification of notochord enhancers enriched upstream of the KIAA0319 transcription start site, in both zebrafish and humans. This study supports a developmental role for KIAA0319 in the brain as well as in other developing structures, particularly in the notochord which, is key for establishing body patterning in vertebrates.
Revision of the fear of cancer recurrence cognitive and emotional model by Lee‐Jones et al with women with breast cancer
Authors: Maheu Christine , Hébert Maude , Louli Julie , Yao Tian‐Ran , Lambert Sylvie , Cooke Andrea , Black Alexandra , Kyriacou Jamie 
Published: April 2019

AbstractBackgroundFear of cancer recurrence (FCR) is among the top unmet concerns reported by breast cancer survivors. Despite the sizable literature on FCR, few theoretical models have been empirically tested. One of the most cited is the FCR model.AimThis study seeks to understand the nature of women's cognitive and emotional issues from FCR using specific guidance from the model by Lee‐Jones and to provide suggestions for modifications to the model based on empirical results from the reported experiences of women living with breast cancer.Methods and resultsA qualitative descriptive study using semi‐structured interviews was conducted at an urban hospital. Recruited by convenience sampling, 12 breast cancer survivors concerned with FCR and who had recently completed active treatment participated in the study. Seven thematic categories emerged from the women's descriptions of their cognitive and emotional experiences with FCR: (a) FCR is always there; (b) beliefs about risk of recurrence; (c) beliefs about eradication of cancer; (d) preferences not to seek information about recurrence; (e) derailment of normal life; (f) worries related to recurrence; and (g) need for support. Adjustments to the model by Lee‐Jones et al1 specifically to women living with breast cancer include the addition of new variables—the fear is always present, a preference not to seek information, and the need for support beyond treatment—and the merging of two variables, anxiety and worry, as participants viewed these concepts as interchangeable and experienced in similar ways. Lastly, participants did not report any remorse related to not opting for more aggressive treatments.ConclusionThe refinement of a more comprehensive FCR theoretical model, such as through the modifications derived from this study, provides a deeper understanding of breast cancer survivors' experiences with FCR and can more effectively guide health care professionals to develop appropriately tailored interventions aimed at decreasing FCR levels.
The role of recombination, niche‐specific gene pools and flexible genomes in the ecological speciation of bacteria
Authors: Schmutzer Michael , Barraclough Timothy Giles 
Published: April 2019

AbstractBacteria diversify into genetic clusters analogous to those observed in sexual eukaryotes, but the definition of bacterial species is an ongoing problem. Recent work has focused on adaptation to distinct ecological niches as the main driver of clustering, but there remains debate about the role of recombination in that process. One view is that homologous recombination occurs too rarely for gene flow to constrain divergent selection. Another view is that homologous recombination is frequent enough in many bacterial populations that barriers to gene flow are needed to permit divergence. Niche‐specific gene pools have been proposed as a general mechanism to limit gene flow. We use theoretical models to evaluate additional hypotheses that evolving genetic architecture, specifically the effect sizes of genes and gene gain and loss, can limit gene flow between diverging populations. Our model predicts that (a) in the presence of gene flow and recombination, ecological divergence is concentrated in few loci of large effect and (b) high rates of gene flow plus recombination promote gene loss and favor the evolution of niche‐specific genes. The results show that changing genetic architecture and gene loss can facilitate ecological divergence, even without niche‐specific gene pools. We discuss these results in the context of recent studies of sympatric divergence in microbes.
Insights into the excited state intramolecular proton transfer process and mechanism of the novel 3‐hydroxythioflavone system: A theoretical study
Authors: Wang Lifei , Wang Yan , Zhao Juan , Zhao Jinfeng 
Published: April 2019

AbstractIt is well known that the molecular excited state dynamical process plays important roles in designing and developing novel applications. In this work, based on density functional theory and time‐dependent density functional theory methods, we theoretically explored a novel 3‐hydroxythioflavone (3HTF). Through calculating the electrostatic potential surface of the 3HTF structure, we confirm the formation of intramolecular hydrogen bonding O2‐H3···O4. Our theoretically obtained dominating bond lengths and bond angles involved in hydrogen bonds demonstrate that the intramolecular hydrogen bonds should be strengthened in the S1 state. Coupling with the simulated infrared vibrational spectra, we further verify the enhanced hydrogen bonding O2‐H3···O4 in the S1 state. Upon photoexcitation, we found that the charge transfer characteristics around hydrogen bonding moieties play important roles in facilitating the excited state intramolecular proton transfer (ESIPT) process. Via constructing potential energy curves in both S0 and S1 states, we confirm the almost nonbarrier ESIPT reaction should be an ultrafast process that further explains the previous experimental phenomenon. At last, we search the S1‐state transition state (TS) structure along with ESIPT path, based on which we simulate the intrinsic reaction coordinate path that further confirms the ESIPT mechanism. We hope that our theoretical work could guide novel applications based on the 3HTF system in future.
Understanding HIV Prevention With College‐Going Black Women: An NIMH‐Funded Pilot Study
Authors: Buckley Tamara R. , Awais Yasmine J. 
Published: April 2019

Black women are disproportionately affected by HIV. Limited research has examined race and gender as psychological variables of influence. In this National Institute of Mental Health pilot study, the authors used semistructured interviews to explore the heterogeneity of identity within race and gender and possible interactions with sexual risk perceptions and behavior in a sample of Black women attending college in an urban city. The article presents emergent themes, recommendations, and questions for future research.El VIH afecta a las mujeres negras de forma desproporcionada. Un número limitado de investigaciones ha examinado la raza y el sexo como variables psicológicas de influencia. En este estudio piloto del Instituto Nacional de Salud Mental, los autores usaron entrevistas semiestructuradas para explorar la heterogeneidad de la identidad dentro de la raza y el sexo, así como posibles interacciones con las percepciones de riesgo y comportamiento sexual en una muestra de mujeres negras cursando estudios universitarios en una ciudad urbana. El artículo presenta temas emergentes, recomendaciones y preguntas para futuras investigaciones.
Using Liberation Psychology and Dialectical Humanism to Understand Latinx Adolescents’ Life Satisfaction and Depressive Symptoms
Authors: Hinojosa Yvette , Vela Javier Cavazos , Guerra Federico , Whittenberg James 
Published: April 2019

The authors conducted a study to examine how the presence of meaning in life, search for meaning in life, hope, family importance, and enculturation influenced Latinx adolescent students’ depressive symptoms and life satisfaction. Two regression models revealed there was a statistically significant relationship between predictor variables, life satisfaction, and depression. The article concludes with a discussion regarding the importance of these findings and recommendations for practice and research.Los autores llevaron a cabo un estudio para examinar cómo la presencia de sentido en la vida, la búsqueda de sentido en la vida, la esperanza, la importancia de la familia y la enculturación influyeron en los síntomas depresivos y satisfacción vital de estudiantes adolescentes Latinx. Dos modelos de regresión revelaron que existe una relación estadísticamente significativa entre las variables de predicción, la satisfacción vital y la depresión. Este artículo concluye con una discusión en torno a la importancia de estos hallazgos, así como recomendaciones para la práctica y la investigación.
Prevalence, correlates of depression, and its impact on quality of life of cancer patients attending a palliative care setting in South India
Authors: Sudarisan Sri Sai Priya , Abraham Bennet , George Christina 
Published: April 2019

AbstractObjectiveDepression is an easily treatable yet frequently underdiagnosed affliction in palliative population with deleterious implications on their quality of life. It has been studied poorly in developing countries like India.MethodsA cross‐sectional study was done with 234 consenting subjects attending a palliative care unit. Patient Health Questionnaire‐9 (PHQ‐9), World Health Organization Quality of Life (WHOQOL‐BREF), and semi‐structured proforma were used by trained nonmental health professional to collect data.ResultsThe prevalence of major depression was 70%. Being a resident of nuclear family (p = .004), absence of insurance coverage (p = .01), presence of financial difficulties (p = .002), and absence of cancer recurrence (p = .001) were significantly associated with major depression in univariate analysis. In multivariate analysis, presence of financial difficulties (OR = 3.9; 95% CI, 2.00‐7.61) and absence of health insurance (OR = 1.92; 95% CI, 1.02‐3.7) were independently associated with major depression. The presence of depression showed significant negative correlation with physical health (p = .03), psychological health (p = .002), and environmental (p = .002) domains of the WHOQOL‐BREF.ConclusionThis study brings to the fore the high rates of depression and its negative impact on the quality of life of terminally ill cancer patients. An improvement in their quality of life requires measures to reduce the rate of underdiagnosed psychiatric morbidities, especially in those who are financially burdened and lack insurance coverage.
A UWB solution for wireless intra‐spacecraft transmissions of sensor and SpaceWire data
Authors: Puschita Emanuel , Ratiu Ovidiu , Drobczyk Martin , Panagiotopoulos Nickolaos , Kirei Botond Sándor , Vos Stefan , Ratiu Vlad , Gärtner Thomas , Pastrav Andra , Palade Tudor 
Published: April 2019

SummaryThis paper presents the design, testing, and validation of a ultra‐wideband (UWB) wireless solution to replace wired intra‐spacecraft communications with wireless communications. The system requirements are provided in the framework of the Eu:CROPIS mission and the wired intra‐spacecraft communication system is replaced with a two‐segment wireless network. As such, distinct sets of UWB gateways and nodes are prototyped to interface with the on‐board entities and properly handle the data transmission in the resulting spacecraft and payload wireless networks. To accomplish these tasks, a custom radio module integrated into the prototypes was designed to provide the appropriate UWB RF front‐end and run a custom‐built communication stack. The viability of the solution was tested in laboratory conditions. For the test scenarios, sensor data are acquired in the payload network and forwarded as SpaceWire packets over the spacecraft network. Experimental test results indicate the suitability of the proposed solution in terms of delay and data integrity for implementing intra‐spacecraft wireless communications.
An overview on consensus‐based approaches to processing collective inconsistency and knowledge integration
Authors: Nguyen Van Du , Truong Hai Bang , Merayo Mercedes G. , Nguyen Ngoc Thanh 
Published: April 2019

The possibility of connecting billions of people around the world through network is the main characteristic of cyber‐physical systems production. To date, social web, virtual communities, and information sharing have been considered as additional sources of information, knowledge which is often referred to as the wisdom of crowds for information retrieval. In these cases, there exists a need to integrate all individual knowledge states originating from different sources concerning some common problems in the real world. Knowledge integration is considered as the key to improve decision quality and enhance the core competency of organizations. For such a task, the most important issue is processing inconsistency of knowledge. The first part of the paper presents an overview of consensus‐based approaches to processing collective inconsistency arising in the integration process. In addition, some issues concerning knowledge integration such as multi‐level integration and knowledge increase in a collective are also devoted. Furthermore, we will investigate the research problem concerning the role of collective knowledge in Collective Intelligence.This article is categorized under:
Technologies > Data Preprocessing
Fundamental Concepts of Data and Knowledge > Knowledge Representation
Fundamental Concepts of Data and Knowledge > Big Data Mining
Resource-Tracking Concurrent Games
Authors: Alcolei Aurore , Clairambault Pierre , Laurent Olivier 
Published: April 2019

AbstractWe present a framework for game semantics based on concurrent games, that keeps track of resources as data modified throughout execution but not affecting its control flow. Our leading example is time, yet the construction is in fact parametrized by a resource bimonoid$$\mathcal {R}$$, an algebraic structure expressing resources and the effect of their consumption either sequentially or in parallel. Relying on our construction, we give a sound resource-sensitive denotation to $$\mathcal {R}$$-IPA, an affine higher-order concurrent programming language with shared state and a primitive for resource consumption in $$\mathcal {R}$$. Compared with general operational semantics parametrized by $$\mathcal {R}$$, our resource analysis turns out to be finer, leading to non-adequacy. Yet, our model is not degenerate as adequacy holds for an operational semantics specialized to time.In regard to earlier semantic frameworks for tracking resources, the main novelty of our work is that it is based on a non-interleaving semantics, and as such accounts for parallel use of resources accurately.
Languages Ordered by the Subword Order
Authors: Kuske Dietrich , Zetzsche Georg 
Published: April 2019

AbstractWe consider a language together with the subword relation, the cover relation, and regular predicates. For such structures, we consider the extension of first-order logic by threshold- and modulo-counting quantifiers. Depending on the language, the used predicates, and the fragment of the logic, we determine four new combinations that yield decidable theories. These results extend earlier ones where only the language of all words without the cover relation and fragments of first-order logic were considered.
Towards a Structural Proof Theory of Probabilistic $$\mu $$ -Calculi
Authors: Lucas Christophe , Mio Matteo 
Published: April 2019

AbstractWe present a structural proof system, based on the machinery of hypersequent calculi, for a simple probabilistic modal logic underlying very expressive probabilistic
$$\mu $$
-calculi. We prove the soundness and completeness of the proof system with respect to an equational axiomatisation and the fundamental cut-elimination theorem.
Justness
Authors: van Glabbeek Rob 
Published: April 2019

AbstractThis paper poses that transition systems constitute a good model of distributed systems only in combination with a criterion telling which paths model complete runs of the represented systems. Among such criteria, progress is too weak to capture relevant liveness properties, and fairness is often too strong; for typical applications we advocate the intermediate criterion of justness. Previously, we proposed a definition of justness in terms of an asymmetric concurrency relation between transitions. Here we define such a concurrency relation for the transition systems associated to the process algebra CCS as well as its extensions with broadcast communication and signals, thereby making these process algebras suitable for capturing liveness properties requiring justness.
Change Actions: Models of Generalised Differentiation
Authors: Alvarez-Picallo Mario , Ong C.-H. Luke 
Published: April 2019

AbstractChange structures, introduced by Cai et al., have recently been proposed as a semantic framework for incremental computation. We generalise change actions, an alternative to change structures, to arbitrary cartesian categories and propose the notion of change action model as a categorical model for (higher-order) generalised differentiation. Change action models naturally arise from many geometric and computational settings, such as (generalised) cartesian differential categories, group models of discrete calculus, and Kleene algebra of regular expressions. We show how to build canonical change action models on arbitrary cartesian categories, reminiscent of the Fàa di Bruno construction.
Short‐ and Long‐Term Outcomes of Liver Resection for Intrahepatic Cholangiocarcinoma Associated with the Metabolic Syndrome
Authors: Hobeika Christian , Cauchy François , Poté Nicolas , Rautou Pierre‐Emmanuel , Durand François , Farges Olivier , Dokmak Safi , Vilgrain Valérie , Ronot Maxime , Paradis Valérie , Soubrane Olivier 
Published: April 2019

AbstractBackgroundWhile the metabolic syndrome (MS) is being recognized as an important risk factor for intrahepatic cholangiocarcinoma (ICC), the outcomes of liver resection in this context remain poorly described. This study aims to report the short‐ and long‐term results of hepatectomy for patients with MS as risk factor for the development of ICC (MS+).MethodsAll patients undergoing hepatectomy for ICC between 2000 and 2016 at a single center were retrospectively analyzed. The perioperative outcomes of MS+ and ICC patients without MS (MS−) were compared.ResultsAmong 115 resected ICC patients, 40 (34.8%) were MS+ and 75 (65.2%) were MS−. MS+ exhibited an increased Charlson comorbidity index (5 ± 2 vs. 2 ± 2, p < 0.001) than MS− patients. While operative characteristics did not differ significantly between the 2 groups, MS+ experienced higher rate of major complications (62.5 vs. 29.3%, p = 0.001). On multivariate analysis, MS+ was an independent risk factor of major complication (HR 2.86, 95% CI 1.07–7.60, p = 0.036) and major cardiorespiratory complication (HR 4.35, 95% CI 1.50–12.62, p = 0.007). Pathological analysis revealed that MS+ displayed higher rates of non‐alcoholic fatty liver disease (60.0 vs. 31.1%, p = 0.003) and non‐alcoholic steatohepatitis (25 vs. 5.4%, p = 0.005). MS+ was independently associated with decreased risk of recurrence (HR 0.47, 95% CI 0.26–0.85, p = 0.001).ConclusionsMS+ accounts for 35% of resected ICC patients. The existence of significant cardiovascular comorbidities increases postoperative morbidity and requires specific management.