bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addressing multiple sources of uncertainty in the estimation of parrot abundance from roost counts: a case study with the Vinaceous-breasted Parrot (Amazona vinacea)
Authors: Zulian Viviane , Müller Eliara Solange , Cockle Kristina L. , Lesterhuis Arne , Júnior Roberto Tomasi , Prestes Nêmora Pauletti , Martinez Jaime , Ferraz Gonçalo 
Published: October 2018

AbstractPopulation size is a key predictor of extinction risk and is critical to listing species in IUCN threat categories. The population size of parrots—one of the most threatened bird families—is often assessed using roost counts, which suffer from multiple sources of uncertainty that need to be addressed in monitoring efforts. To improve estimates of abundance for endangered Vinaceous-breasted Parrot (Amazona vinacea), we compared extensive roost counts over the whole range of the species (Argentina, Paraguay, Brazil) with an intensive regional survey designed to address five sources of uncertainty about parrot abundance in western Santa Catarina state (WSC), Brazil, in 2016 and 2017. We estimated regional-scale abundance using a sampling design that minimizes double counting and an N-mixture model of replicated count data, which accounts for imperfect detection, implemented in a Bayesian framework. The whole-range counts amounted to 3,888 and 4,084 individuals in 2016 and 2017, respectively; regional estimates were 945 ± 50 and 1,393 ± 40 individuals, for the same two years. We found no evidence of population growth because the increase in numbers matched an increase in observation effort on both spatial scales. When extrapolating the WSC abundance estimate to three hypothetical geographical range areas of the species, under the simplifying assumption of homogenous density, we obtained values above the whole-range counts, but within the same order of magnitude, putting the global population size of Vinaceous-breasted Parrot in the thousands of individuals. Although our estimates of abundance and geographic range are larger than those currently reported by the IUCN, we suggest that Vinaceous-breasted Parrot remain in the ‘Endangered’ IUCN threat category pending further investigation of population trends. We recommend that roost-monitoring programs for parrots consider and address sources of uncertainty through field protocols and statistical analysis, to better inform assessments of population size, trends, and threat status.
Piezo1 channel agonist mimics high glucose as a stimulator of insulin release
Authors: Deivasikamani Vijayalakshmi , Dhayalan Savitha , Mughal Romana , Visnagri Asjad , Cuthbertson Kevin , Scragg Jason L , Munsey Tim S , Viswambharan Hema , Foster Richard , Sivaprasadarao Asipu , Kearney Mark T , Beech David J , Sukumar Piruthivi 
Published: October 2018

AbstractObjectiveGlucose and hypotonicity induced cell swelling stimulate insulin release from pancreatic β-cells but the mechanisms are poorly understood. Recently, Piezo1 was identified as a mechanically-activated nonselective Ca2+permeable cationic channel in a range of mammalian cells. As cell swelling induced insulin release could be through stimulation of Ca2+permeable stretch activated channels, we hypothesised a role for Piezo1 in cell swelling induced insulin release.MethodsTwo rat β-cell lines (INS-1 and BRIN-BD11) and freshly-isolated mouse pancreatic islets were studied. Intracellular Ca2+measurements were performed using the fura-2 Ca2+indicator dye. Piezo1 agonist Yoda1, a competitive antagonist of Yoda1 (Dooku1) and an inactive analogue of Yoda1 (2e) were used as chemical probes. Piezo1 mRNA and insulin secretion were measured by RT-PCR and ELISA respectively.ResultsPiezo1 mRNA was detected in both β-cell lines and mouse islets. Yoda1 evoked Ca2+entry which was inhibited by Yoda1 antagonist Dooku1 as well as other Piezo1 inhibitors gadolinium and ruthenium red, and not mimicked by 2e. Yoda1, but not 2e, stimulated Dooku1-sensitive insulin release from β-cells and pancreatic islets. Hypotonicity and high glucose increased intracellular Ca2+and enhanced Yoda1 Ca2+influx responses. Pre-treatment with ruthenium red significantly reduced hypotonicity induced insulin release from β-cells and pancreatic islets.ConclusionThe data show that Piezo1 channel agonist induces insulin release from β-cell lines and mouse pancreatic islets suggesting a role for Piezo1 in cell swelling induced insulin release. Hence Piezo1 agonists have a potential to be used as enhancers of insulin release.
Genome editing reveals reproductive and developmental dependencies on specific types of vitellogenin in zebrafish (Danio rerio)
Authors: Yilmaz Ozlem , Patinote Amelie , Nguyen Thaovi , Com Emmanuelle , Pineau Charles , Bobe Julien 
Published: October 2018

ABSTRACTOviparous vertebrates produce multiple forms of vitellogenin (Vtg), the major source of yolk nutrients, but little is known about their individual contributions to reproduction and development. This study employed a CRISPR/Cas9 genome editing to assess essentiality and functionality of zebrafish (Danio rerio) type-I and -III Vtgs. The multiple CRISPR approach employed to knock out (KO) all genes encoding type-Ivtgs(vtg1, 4, 5, 6,and7) simultaneously (vtg1-KO), and the type-IIIvtg(vtg3) individually (vtg3-KO). Results of PCR genotyping and sequencing, qPCR, LC-MS/MS and Western blotting showed that onlyvtg6andvtg7escaped Cas9 editing. In fish whose remaining type-Ivtgswere incapacitated (vtg1-KO), and invtg3-KO fish, significant increases in Vtg7 transcript and protein levels occurred in liver and eggs, a heretofore-unknown mechanism of genetic compensation to regulate Vtg homeostasis. Fecundity was more than doubled invtg1-KO females, and fertility was ~halved invtg3-KO females. Substantial mortality was evident invtg3-KO eggs/embryos after only 8 h of incubation and invtg1-KO embryos after 5 d. Hatching rate and timing were markedly impaired invtgmutant embryos and pericardial and yolk sac/abdominal edema and spinal lordosis were evident in the larvae, with feeding and motor activities also being absent invtg1-KO larvae. By late larval stages,vtgmutations were either completely lethal (vtg1-KO) or nearly so (vtg3-KO). These novel findings offer the first experimental evidence that different types of vertebrate Vtg are essential and have disparate requisite functions at different times during both reproduction and development.
Genetic variation for ontogenetic shifts in metabolism underlies physiological homeostasis inDrosophila
Authors: Matoo Omera B. , Julick Cole R. , Montooth Kristi L. 
Published: October 2018

AbstractOrganismal physiology emerges from metabolic pathways and structures that can vary across development and among individuals. Here we tested whether genetic variation at one level of physiology can be buffered at higher levels during development by the inherent capacity for homeostasis in physiological systems. We found that the fundamental scaling relationship between mass and metabolic rate, as well as the oxidative capacity per mitochondria, differed significantly across development in the fruit flyDrosophila. However, mitochondrial respiration rate was maintained across development at similar levels. Furthermore, genotypes clustered into two types—those that switched to aerobic, mitochondrial ATP production before the second instar and those that relied on anaerobic production of ATP via glycolysis through the second instar. Despite genetic variation for the timing of this metabolic shift, second-instar metabolic rate was more robust to genetic variation than was the metabolic rate of other instars. We also found that a mitochondrial-nuclear genotype with disrupted mitochondrial function both increased aerobic capacity more through development and relied more heavily on anaerobic ATP production relative to wildtype genotypes. By taking advantage of both ways of making ATP, this genotype maintained mitochondrial respiratory capacity, but also generated more free radicals and had decreased mitochondrial membrane potential, potentially as a physiological-defense mechanism. Taken together, the data revealed that genetic defects in core physiology can be buffered at the organismal level via physiological compensation and that natural populations likely harbor genetic variation for distinct metabolic strategies in development that generate similar organismal outcomes.
Awareness, knowledge and attitude of lecturers towards institutional repositories in university libraries in Nigeria
Authors: Okoroma Francisca Nwakaego 
Published: October 2018

Purpose
Content recruitment is a very crucial aspect of institutional repository (IR), and yet, a major challenge in the implementation of an IR system. Literature highlighted the numerous issues associated with IR implementation in the Sub-Saharan Africa, including Nigeria, and the necessity to review and tackle the divergent challenges of institutional repositories. This study aims to address the issues of awareness, knowledge and attitude of lecturers towards institutional repositories in university libraries in Nigeria.

Design/methodology
The study adopted the descriptive survey research design. A multistage sampling procedure was used to sample 751 lecturers of the universities in Nigeria and eight heads of the digitization section of the libraries. Data generated were analyzed using descriptive statistics.

Findings
The findings revealed that majority of the lecturers in Nigeria are either unfamiliar with the term IR or have very little level of knowledge on the aims and objectives of IR, and therefore have low disposition to submitting their work. The study identified various options to resolve the problem of awareness, knowledge and pessimistic attitude of lecturers towards IRs, including massive awareness and enlightenment programmes on the subject of IR and on copyright issues within the university communities in Nigeria.

Originality
The study will enhance the awareness and advocacy of IR in Nigeria. The awareness and knowledge of IR will bring about positive attitudinal change of lecturers towards investing into IRs.
Effects of China’s environmental policy on carbon emission efficiency
Authors: Pan Xiongfeng , Pan Xianyou , Li Changyu , Song Jinbo , Zhang Jing 
Published: October 2018

PurposeThe purpose of this paper is to analyze the effect of environmental policyChina’s national program to address climate changeon carbon emission efficiency.DesignBased on the directional distance function, the provincial total factor carbon emission efficiency was measured. Then, the authors analyzed the effect of environmental policy on carbon emission efficiency based on a difference in difference model.FindingCarbon emission efficiency has been significantly improved since the environmental policyChina’s national program to address climate changewas put forwarded, but the positive impact in different periods and regions is different. In addition, the environmental policy improves the carbon emission efficiency through the reduction of energy intensity and adjustment of the industrial structure.Originality/valueThis is the first time to use difference in difference model to use a difference in difference model to quantitatively assess the influence of environmental policyChina’s national program to address climate changeon carbon emission efficiency.
The impact of business networks on foreign subsidiaries development
Authors: Baraldi Enrico , Ciabuschi Francesco , Lindahl Olof , Perna Andrea , Gregori Gian Luca 
Published: October 2018

Purpose
The purpose of this paper is to explore two specific areas pertaining to industrial networks and international business (IB). First, the authors look at how business relationships influence the internationalization in time, from the establishment of the first subsidiary in a foreign market to the following ones, and in space, that is, across different markets. Second, the authors investigate how an increasing external network dependence of subsidiaries in their internationalization may cause a detachment of a subsidiary from the mother company as its knowledge becomes insufficient to guide a subsidiary’s internationalization.

Design/methodology/approach
This paper utilizes an exploratory, longitudinal, single-case study of Loccioni – a manufacturer of measuring and automatic control systems for industrial customers – to illustrate the specific dynamics of the influences of industrial networks on the internationalization of subsidiaries.

Findings
The case study helps to elucidate the roles, entailing also free will and own initiative, of small suppliers’ subsidiaries which operate inside several global factories, and how “surfing” on many different global factories, by means of several local subsidiaries, actually supports these suppliers’ own international developments. This notion adds to our understanding of the global factory phenomenon a supplier focus that stresses how the role of suppliers is not merely that of being passive recipients of activities and directions from a focal orchestrating firm, but can also be that of initiative-takers themselves.

Originality/value
The paper contributes to the IMP tradition by providing a multi-layered and geographically more fine-grained view of the network embedding companies that operate on internationalized markets. This paper thereby sheds light on a less investigated area of research within the IMP tradition: the link between internationalization in different countries and the interconnectedness between the industrial networks spanning these countries. At the same time, this paper contributes to IB theories by showing how a late-internationalizing SME can enter highly international markets by “plugging into” several established “Global Factories” as a way to exploit further opportunities for international expansion.
Do sales people trust new customers because of who they are?
Authors: Gaczek Piotr , Leszczynski Grzegorz , Zielinski Marek 
Published: October 2018

PurposeThe purpose of this paper is to identify the interplay between the characteristics of trustee and trustor in trust formation at the initial stage of a relationship in the B2B context.Design/methodology/approachThe study was experimental. A situation was simulated in which sales managers choose prospective customers on whom his or her company should concentrate after entering the new market. A total of 108 managers participated in the study.FindingsThe results indicate that during the pre-relationship stage salespeople declared trust toward a prospective customer despite having no previous interactions with the other party. Salespeople start the trust-development process by gathering clues about the trustworthiness of the potential partner organization. The cognitive information provided to salespeople impacts interpersonal trust to a greater extent than effective communication. This influence is moderated by trustor trust propensity. There is no difference in the type of information about a trustor when it comes to organizational reliance.Originality/valueThis paper provides a new insight into research on trust in interorganizational relationships as the authors adopted the perspective of the supplier who is most frequently perceived as a trustee, rather than a trustor. It directs attention to the pre-relationship stage, which precedes the interaction that may lead to a relationship developing but also links the object of trust (trustee) with the subject of trust (trustor) and integrates two separate approaches to the ascendance of trust with its multi-dimensional and multi-level nature. Moreover, an experimental design that is rare in research on business relationships was implemented.
The four executive challenges of project-based strategy
Authors: Lund Pedersen Carsten , Ritter Thomas 
Published: October 2018

Purpose
As a great deal of strategy execution takes the form of strategic projects, how you align these projects ultimately determines the success or failure of your strategy. Here, we discuss four executive challenges executives need to tackle to successfully manage a strategy in a project-based world.

Design/methodology/approach
Conceptual approach entailing illustrative case-examples

Findings
We find four executive challenges to tackle in order to successfully manage a strategy in a project-based world.

Research limitations/implications
As the study draws upon conceptual arguments, future studies need to assess the verisimilitude and boundary conditions of the challenges.

Practical implications
By thinking of a strategy through a project-based lens, and understanding the challenges thereof, executives should be better able to bridge strategy formulation and execution.

Social implications
A project-based approach to strategy is not necessarily limited to a for-profit sector; NGOs and governmental organizations may similarly learn from and draw upon a project-based approach to strategy.

Originality/value
As little research within strategy has explicitly conveyed a project-based lens, the study emphasizes a novel approach to strategy.
Boreal tree growth exhibits decadal‐scale ecological memory to drought and insect defoliation, but no negative response to their interaction
Authors: Itter Malcolm S. , D'Orangeville Loïc , Dawson Andria , Kneeshaw Daniel , Duchesne Louis , Finley Andrew O. 
Published: October 2018

Abstract

Interactions between drought and insect defoliation may dramatically alter forest function under novel climate and disturbance regimes, but remain poorly understood. We empirically tested two important hypotheses regarding tree responses to drought and insect defoliation: (a) trees exhibit delayed, persistent, and cumulative growth responses to these stressors; (b) physiological feedbacks in tree responses to these stressors exacerbate their impacts on tree growth. These hypotheses remain largely untested at a landscape scale, yet are critical for predicting forest function under novel future conditions, given the connection between tree growth and demographic processes such as mortality and regeneration.

We developed a Bayesian hierarchical model to quantify the ecological memory of tree growth to past water deficits and insect defoliation events, derive antecedent variables reflecting the persistent and cumulative effects of these stressors on current growth, and test for their interactive effects. The model was applied to extensive tree growth, weather, and defoliation survey data from western and eastern regions of the Canadian boreal forest impacted by recent drought and defoliation events and characterized by contrasting tree compositions, climates, and insect defoliators.

Results revealed persistent negative tree growth responses to past water (all trees) and defoliation (host trees) stress lasting 3–6 and 10–12 years, respectively, depending on study region. Accounting for the ecological memory of tree growth to water and defoliation stress allowed for detection of interactions not previously demonstrated. Contrary to expectations, we found evidence for positive interactions among non‐host trees likely due to reduced water stress following defoliation events. Regional differences in ecological memory to water stress highlight the role of climate in shaping forest responses to drought.

Synthesis. Study results suggest negative feedbacks in tree responses to drought and insect attack may be weaker than predicted for defoliator‐dominated boreal forest systems. Instead, insect defoliation may offset the impacts of water deficit on boreal tree growth by reducing transpirational water demand. This offset mimics increased resistance to drought following forest thinning and may lessen growth and mortality losses due to increased aridity and more severe insect damage forecast for the boreal forest under global change.
The role of galectin‐3 in heart failure and cardiovascular disease
Authors: Zhong Xiao , Qian Xiaoqian , Chen Guangping , Song Xiang 
Published: October 2018

SummaryGalectin‐3, a β‐galactoside‐binding lectin, is a new important player in the progression of heart failure (HF) and is also linked to poor outcome in patients with cardiovascular disease. Genetic or pharmacological inhibition of galectin‐3 slows down the progression of myocardial inflammation, reduces collagen production, attenuates cardiac remodelling, and ameliorates cardiac function. In this review, we summarize recent progress in research on galectin‐3 as a regulatory molecule involved in cardiovascular fibrosis in HF and its potential role in the diagnosis, risk assessment and treatment of cardiovascular diseases.
Microbial trimethylamine metabolism in marine environments
Authors: Sun Jing , Mausz Michaela A. , Chen Yin , Giovannoni Stephen J. 
Published: October 2018

SummaryTrimethylamine (TMA) is common in marine environments. Although the presence of this compound in the oceans has been known for a long time, unlike the mammalian gastrointestinal tract, where TMA metabolism by microorganisms has been studied intensely, many questions remain unanswered about the microbial metabolism of marine TMA. This minireview summarizes what is currently known about the sources and fate of TMA in marine environments and the different pathways and enzymes involved in TMA metabolism in marine bacteria. This review also raises several questions about microbial TMA metabolism in the marine environments and proposes potential directions for future studies.
The incidence of atrial fibrillation with trastuzumab treatment: A systematic review and meta‐analysis
Authors: Yuan Ming , Tse Gary , Zhang Zhiwei , Han Xu , Wu William K. K. , Li Guangping , Xia Yunlong , Liu Tong 
Published: October 2018

SummaryAimCases of cardiotoxicity related to trastuzumab have been reported. This systematic review and meta‐analysis evaluated the risk of atrial fibrillation (AF) in patients of breast cancer treated with trastuzumab.MethodsPubMed and EMBASE were searched until September 2017 for articles that investigated AF incidence in patients receiving trastuzumab for breast cancer.ResultsA total of 15 studies involving 8124 patients treated with trastuzumab were included. Of the total cohort, 37 patients suffered from AF, giving rise to an incidence of 1.22% (95% confidence interval [CI]: 0.56%‐2.68%). No significant difference in the incidence of AF was found between ado‐trastuzumab emtansine (0.95%, 95% CI: 0.36%‐2.52%) and trastuzumab groups (1.32%, 95% CI: 0.52%‐3.34%), trastuzumab combined with other antineoplastic agents (2.09%, 95% CI: 1.16%‐3.73%) and trastuzumab alone (0.36%, 95% CI: 0.04%‐3.08%), prior exposure to anthracyclines (1.72%, 95% CI: 0.75%‐3.88%) and no prior exposure (1.03%, 95% CI: 0.30%‐3.51%), and radiotherapy (1.26%, 95% CI: 0.68%‐2.33%) vs. no radiotherapy (1.21%, 95% CI: 0.35%‐4.14%).ConclusionsAtrial fibrillation incidence in breast cancer patients receiving trastuzumab was around 1.2%. It was not influenced by the formulation of trastuzumab, the additional use of neoplastic agents, anthracycline exposure status, or concurrent radiotherapy.