bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of predictive models of early immune effector cell–associated hematotoxicity
Authors: Liang Emily C. , Huang Jennifer J. , Portuguese Andrew J. , Ortiz-Maldonado Valentín , Albittar Aya , Wuliji Natalie , Basom Ryan , Jeon Yein , Wu Qian , Torkelson Aiko , Kirchmeier Delaney , Chutnik Abigail , Pender Barbara , Sorror Mohamed , Hill Joshua A. , Kopmar Noam E. , Banerjee Rahul , Cowan Andrew J. , Green Damian , Gopal Ajay K. , Poh Christina , Shadman Mazyar , Hirayama Alexandre V. , Till Brian G. , Kimble Erik L. , Iovino Lorenzo , Chapuis Aude G. , Otegbeye Folashade , Cassaday Ryan D. , Milano Filippo , Turtle Cameron J. , Maloney David G. , Gauthier Jordan 
Published: December 2024

Abstract
Immune effector cell–associated hematotoxicity (ICAHT) is associated with morbidity and mortality after chimeric antigen receptor (CAR) T-cell therapy. To date, the factors associated with ICAHT are poorly characterized, and there is no validated predictive model of ICAHT as defined by current consensus criteria. Therefore, we performed comprehensive univariate analyses to identify factors associated with severe (grade 3-4) early ICAHT (eICAHT) in 691 patients who received commercial or investigational CAR T-cell therapy for hematologic malignancies. In univariate logistic regression, preinfusion factors associated with severe eICAHT included disease type (acute lymphoblastic leukemia), prelymphodepletion (pre-LD) blood counts including absolute neutrophil count (ANC), lactate dehydrogenase (LDH), and inflammatory (C-reactive protein [CRP], ferritin, and interleukin-6 [IL-6]) and coagulopathy biomarkers (D-dimer). Postinfusion laboratory markers associated with severe eICAHT included early and peak levels of inflammatory biomarkers (CRP, ferritin, and IL-6), coagulopathy biomarkers (D-dimer), peak cytokine release syndrome grade, and peak neurotoxicity grade. We trained (n = 483) and validated (n = 208) 2 eICAHT prediction models (eIPMs): eIPMPre including preinfusion factors only (disease type and pre-LD ANC, platelet count, LDH, and ferritin) and eIPMPost containing both preinfusion (disease type and pre-LD ANC, platelet count, and LDH) and early postinfusion (day +3 ferritin) factors. Both models generated calibrated predictions and high discrimination (area under the receiver operating characteristic curve in test set, 0.87 for eIPMPre and 0.88 for eIPMPost), with higher net benefit in decision curve analysis for eIPMPost. Individualized predictions of severe eICAHT can be generated from both eIPMs using our online tool (available at https://eipm.fredhutch.org).
Effect of Pulsed Current Treatment on Microstructure and Properties of 304 Stainless Steel Ultra-Thin Strip after Rolling
Authors: Liu Qi , Fan Wanwan , Ren Zhongkai , Wang Tao , Huang Qingxue 
Published: December 2024

AbstractThe annealing process is usually used to heat-treat cold-deformed 304 stainless steel to improve its microstructure and properties to a certain extent; however, it requires a high temperature and a long time. Because the thickness of the ultrathin strip reaches the micrometer level, it has only one or several layers of grains in the thickness direction, and the control of morphology and performance is complex. In this study, pulsed current loading was used to replace traditional annealing for treating ultrathin strips of cold-rolled 304 stainless steel. After loading a 25 W pulsed current treatment for 5 min on the cold-rolled sample, which had a thickness of 0.035 mm and width of 6 mm, complete recrystallization occurred, and the mechanical properties were significantly improved. At this point, the measured temperature was 540 °C. When annealing was used to treat the sample with the same temperature and for the same duration, the microstructure was still dominated by deformed crystals, and the mechanical properties were poor. When annealing was used to obtain a microstructure and properties similar to those obtained via 25 W electrical treatment, the required annealing temperature and time were 810 °C and 60 min, respectively. Pulsed current can increase the vacancy diffusion flux in the sample, accelerate the atomic movement, reduce the recrystallization activation energy, and make the cold-rolled 304 stainless steel ultrathin strip completely recrystallize at a lower temperature and in a shorter time. As the current power continued to increase, the recrystallized grains grew. When the pulsed current power was increased to 25 W, the recrystallized grains grew negligibly. Both recrystallization and grain growth have power thresholds. This study provides a novel approach for regulating the microstructure and mechanical properties of ultrathin cold-rolled 304 stainless steel strips.
Research on Parameters Optimization of Rectangular Pole Teeth for Magnetic Fluid Seals
Authors: Wang Lu , Zhang Zhili , Li Decai , Liang Zhiqi , Di Nannan , Li Liu 
Published: December 2024

AbstractTo optimize the magnetic fluid seal design, the single-factor method is usually used to study the effect of the rectangular pole teeth structure parameters on the sealing capacity of the magnetic fluid seal by current research, and the design formula is obtained. However, the supporting data is too few to make the results universalizable. In this paper, to obtain a wider range of applicable design formulas, a large number of modeling and simulation experiments are conducted using the co-simulation analysis experimental method of MATLAB and COMSOL. The influence of structure parameters of rectangular pole teeth and the coupling effects of the structure parameters on the sealing capacity of sealing devices has been studied under different lengths of pole piece (Lp) and seal gap (Lg). The results explain the influences of tooth height (Lh), tooth width (Lt), groove width (Ls), and their coupling effects on the theoretical sealing capacity of magnetic fluid seals, and more widely applicable design formulas for pole teeth structure parameters are given. The design formulas can help to obtain good design parameters directly or reduce the optimization range when the magnetic fluid seals need to be optimized to meet the miniaturization and lightweight requirements of magnetic fluid sealing devices or improve the sealing capacity under the same seal size.
Response strategies of five common warm temperate plant species to insect defoliation
Authors: Wang Ning , Li Qiang , Wu Pan , Yi Shijie , Ji Hongliang , Liu Xiao , He Tongli 
Published: December 2024

AbstractUnder the background of global climate change, climate warming has led to an increase in insect herbivory, which significantly affects the growth, survival, and regeneration of forest plants in the warm temperate zone of China. Plants can adopt defense responses to adapt to insect defoliation. Therefore, field experiments were conducted on five common warm temperate species, Quercus acutissima, Quercus serrata, Quercus aliena, Quercus dentata, and Robinia pseudoacacia. We measured the leaf traits of healthy trees and insect defoliated trees, to explore the response strategies of common species in warm temperate zones to insect defoliation. Our results showed that native species stored more carbon in extreme environments for survival rather than growth, while the alien species R. pseudoacacia tended to adopt active resource acquisition strategies and were more inclined towards growth. The content of tannins and flavonoids in the alien species R. pseudoacacia did not significantly increase after leaf damage, while the content of secondary metabolites such as tannins, flavonoids, and total phenols in the native species Q. acutissima, Q. serrata, Q. aliena, Q. dentata increased significantly after leaf damage. This indicated that compared to alien species, native species invested more resources in defense, which might reduce resource allocation for growth. Thus, the native Quercus species have stronger resistance than the alien species R. pseudoacacia after insect defoliation.
A digital and nurse-led support intervention, first year after prostate cancer treatment: a single-arm feasibility study in a Swedish primary care setting
Authors: Kelmendi Nazmije , Langius-Eklöf Ann , Taloyan Marina , Sundberg Kay , Craftman Åsa , Nilsson Marie 
Published: December 2024

Abstract
Background
The prevalence of patients with prostate cancer is increasing, and the first year after treatment is a vulnerable period for patients as they experience symptoms and unmet needs. Although electronic patient-reported outcomes that focus on patient self-management have demonstrated benefits, evidence is sparse regarding patients with prostate cancer in primary care settings and the role of nurses as a supportive resource. The significant role of primary care in future cancer care is on the agenda. This study aims to test the feasibility of a complex intervention that includes electronic patient-reported outcomes and self-management advice in an app, combined with nurse-led support, in primary care settings during the first year after curative intended prostate cancer treatment.

Methods
The intervention lasted four weeks and was a single-arm study. Feasibility was assessed by examining the recruitment process, retention rate, adherence to the reporting of symptoms in the app, and acceptability of the intervention. Data was collected through (1) logged data from the app that included patient-reported outcomes and self-management advice, (2) field notes by the nurse, and (3) semi-structured interviews with patients. Descriptive statistics were applied to logged data. The interviews and the field notes were analysed using qualitative content analysis.

Results
The recruitment rate was 55%, yielding 11 patients with high retention as all completed the intervention. Adherence to reporting was 100%, and all functions in the app were used. Individual variation in how patients used the app was found, which was attributed to patients’ current needs. In total, 36 health dialogues with the nurse (virtual, face-to-face, telephone) were performed; all first dialogues lasted longer, while follow-ups were shorter. Patients described that the health dialogues covered relevant subjects and that the combination of using the app and health dialogues was tailored and provided supplementary support. No adverse events occurred; however, a few technical difficulties interfered with the intervention, and the patients gave valuable suggestions for improvement. Furthermore, patients suggested that the intervention should start immediately after treatment.

Conclusion
As the patients adhered to and accepted the intervention, it was considered feasible. Findings suggest intervention should start directly after treatment ends.
CKD in reproductive-aged women: a call for early nephrology referral and multidisciplinary care
Authors: Srialluri Nityasree , Thavarajah Sumeska 
Published: December 2024

AbstractChronic Kidney Disease (CKD) affects millions globally, with a notable impact on biological females of reproductive age. This population faces specific issues such as fertility concerns, complex contraceptive decisions, and complications related to pregnancy that can exacerbate CKD. Given the increasing prevalence of CKD among young men and women owing to rising rates of hypertension, obesity, and diabetes, there is a need for early and tailored interventions among women of childbearing age. Current Kidney Disease Improving Global Outcomes (KDIGO) guidelines suggest nephrology referral primarily for advanced CKD stages or significant proteinuria. However, women at any CKD stage may face complex pregnancy-related decisions and increased risks that are not adequately addressed by these guidelines, warranting early specialty care. This review explores the distinct needs of women of reproductive age with CKD, identifies gaps in the existing management framework, and advocates for earlier and more comprehensive nephrology involvement. By focusing on preconception planning, risk factor management, adverse pregnancy outcomes, and existing disparities in care, this review seeks to improve understanding of the needs of women of reproductive age with CKD and calls for a shift towards more proactive, nephrology-driven care.
Psychological distress does not predict decisional regret in patients undergoing spinal reconstruction for adult spinal deformity
Authors: Shen Jesse , Louie Philip , Fujii Takeshi , Drolet Caroline E. , Bansal Aiyush , Nemani Venu , Leveque Jean-Christophe , Sethi Rajiv 
Published: December 2024

Abstract
Purpose
The study aimed to assess the link between preoperative psychological distress and postoperative decisional regret in adult spinal deformity (ASD) surgery patients. We hypothesized that greater pre-surgery distress would correlate with higher post-surgery regret. This evaluation was based on a retrospective case series from an institution with standardized surgical guidelines for ASD.

Methods
This IRB-approved retrospective study analyzed our institution’s ASD database from 2014 to 2020. Eligible patients had a minimum two-year post-op follow-up and preoperative psychological distress assessment. Patients were grouped based on psychological distress levels: green, yellow, and yellow minus. Regret post-surgery was assessed using the Decision Regret Scale and SRS-22 Question 22. Logistic regression evaluated the impact of distress levels on regret, controlling for age and sex.

Results
Out of 167 eligible patients, 112 responded and were analyzed. No significant demographic differences were observed between responders and non-responders. Using the Decision Regret Scale, 41% expressed no regret, while 63% expressed no regret with the SRS-22 questionnaire’s Single-Item scale. Only the yellow minus group showed significant regret difference based on osteotomy, with non-recipients more likely to express regret.

Conclusion
This study found no significant link between psychological distress and post-operative regret in adult spinal deformity surgery after a minimum 2-year follow-up. Although nearly 60% exhibited some post-surgery regret, predicting regret based on psychological burden or demographics remains challenging. Further research is essential to identify factors contributing to post-operative regret in spinal deformity surgery patients.
Talent management in volatility, uncertainty, complexity, and ambiguity (VUCA) health environment, nurses’ psychological contract fulfillment, cordial relation and generation: moderation-mediation model
Authors: Ellethiey Nancy Sabry , Ashour Heba Mohamed Al-Anwer Ali , Awad Nadia Hassan Ali 
Published: December 2024

Abstract
Background
The VUCA in the healthcare environment requires combating volatility, uncertainty, complexity, and ambiguity through highly talented employees and implementing a talent management strategy. This encompasses a range of operations designed to find, attract, nurture, and utilize competent workers that impact how well nurses fulfill their psychological contracts. However, as the researchers had anticipated, several factors, such as cordial relationships and generation differences, may mediate or influence this correlation.

Methods
For a cross-sectional study, a non-probability convenience sampling technique was used to include n = 375 nurses from among the 600 total nurses at three private hospitals in Alexandria, Egypt. Three validated measures were used to measure the study variables and develop a mediation-moderation structural equation model.

Results
The result of this study revealed that nurses perceived a moderate level of talent management with a mean score of (48.91 ± 18.15), a low mean score (8.89 ± 3.93) of psychological contract fulfillment, and a moderate mean score (185.11 ± 27.02) of cordial relation. Additionally, more than half of the participants were in the Gen Z. Also, this study concluded that there is a positive mediation role of cordial relation and a negative moderation role of Gen between talent management and psychological contract fulfillment.

Conclusions
Using Gen as a moderating variable and cordial relations as a mediating factor, a moderating mediating structural equation model is created and validates the important influence of talent management on nurses’ psychological fulfillment, confirming the mediating effect of cordial relations and the moderating effect of genes in this relationship. GEN negatively predicted psychological contract fulfillment, meaning baby boomers predicted more psychological contract fulfillment than Z gen. Furthermore, talent management could positively predict cordial relations and psychological contract fulfillment, and cordial relations partially mediated the relationship between talent management and psychological contract fulfillment. Nurse mangers should be aware of and implement effective and talent management strategies with respecting gen difference, and apply tailored strategies for fostering nurses’ cordial relation and psychological contract fulfillment to deal with the VUCA challenging healthcare environment.
Lysosomal gene ATP6AP1 promotes doxorubicin resistance via up-regulating autophagic flux in breast cancer
Authors: Fei Yinjiao , Yan Xueqin , Liang Mingxing , Zhou Shu , Xu Di , Li Lei , Xu Weilin , Song Yuxin , Zhu Zhen , Zhang Jian 
Published: December 2024

Abstract
Background
Breast cancer remains the most prevalent malignancy in women. Chemotherapy is the primary systemic treatment modality, and the effectiveness of treatment is often hampered by chemoresistance. Autophagy has been implicated in promoting chemoresistance, as elevated autophagic flux supports tumor cell survival under therapeutic stress. Since lysosomes are essential for the completion of autophagy, their role in autophagy-related chemoresistance has been insufficiently studied. This study aims to elucidate the role of the lysosomal gene ATP6AP1 in promoting chemoresistance in breast cancer by upregulating autophagic flux.

Methods
Doxorubicin-induced cell death was assessed by cytotoxicity, flow cytometry, lactate dehydrogenase (LDH) release assays in various breast cancer cell lines. Autophagic flux was assessed with western blot and the mRFP-GFP-LC3 fluorescence imaging. Breast cancer cells were infected with shRNA lentivirus targeting ATP6AP1, allowing investigation its tole in doxorubicin-induced cell death. ATP6AP1 expression and its association with prognosis were evaluated using public databases and immunohistochemistry.

Results
Doxorubicin-induced cell death in breast cancer cells is negatively correlated with increased autophagic flux and lysosomal acidification. The lysosomal gene ATP6AP1, which plays a role in autophagic processes, is upregulated in breast cancer tissues. Knocking down ATP6AP1 reduces autophagy-mediated doxorubicin resistance by inhibiting autophagic flux and lysosomal acidification in breast cancer cells. Data analysis from public databases and our cohort indicate that elevated ATP6AP1 expression correlates with poor response to doxorubicin-based neoadjuvant chemotherapy (NAC) and worse prognosis.

Conclusions
Doxorubicin-induced cytotoxicity is associated with autophagy flux in breast cancer. The lysosomal gene ATP6AP1 facilitates autolysosome acidification and contributes to doxorubicin resistance in breast cancer.
Larval source management in Ethiopia: modelling to assess its effectiveness in curbing malaria surge in dire Dawa and Batu Towns
Authors: Ayana Galana Mamo , Jalilian Abdollah , Ashine Temesgen , Molla Eshetu , Hailemeskel Elifaged , Yemane Dagmawi Hailu , Yirgu Hailegiorgis , Negash Nigatu , Teferi Natnael , Teshome Daniel , Reynolds Alison M. , Weetman David , Wilson Anne L. , Kenate Birhanu , Donnelly Martin J. , Sedda Luigi , Gadisa Endalamaw 
Published: December 2024

Abstract
Background
Ethiopia faces several severe challenges in terms of malaria elimination, including drug resistance and diagnostic evasion in the Plasmodium falciparum parasite, insecticide resistance in the primary Anopheles malaria vector, and, most recently, the invasion of the Asian malaria vector Anopheles stephensi. Novel malaria control methods are therefore needed, and in this paper, we describe the evaluation of a larval source management (LSM) strategy implemented in response to An. stephensi. The primary outcome was the malaria incidence rate compared between intervention and non-intervention sites in the presence of An. stephensi.

Methods
Intervention (Batu and Dire Dawa) and control (Metehara) towns were selected, and weekly malaria passive case detection data collected between 2014 and 2023 were obtained from the Oromia regional state and Dire Dawa City Administration Health Bureau. In addition, data regarding intervention were obtained from the President’s Malaria Initiative (PMI) reports. Weekly malaria passive case data were used to evaluate the change in the estimated malaria incidence rate and trends of temporal patterns of the estimated malaria incidence rate before and after interventions. An interrupted time series model with a cyclic second-order random walk structure periodic seasonal term was used to assess the impact of LSM on malaria incidence rate in the intervention and control settings.

Results
An upsurge in malaria cases occurred after 2020 at both the intervention and control sites. The temporal patterns of malaria incidence rate showed an increasing trend after the intervention. The ITS model depicted that the LSM has no impact in reducing the malaria incidence rate at both intervention site Dire Dawa [immediate impact = 1.462 (0.891, 2.035)], [Lasting impact = 0.003 (− 0.012, 0.018)], and Batu [Immediate impact 0.007 (− 0.235, 0.249), [Lasting impact = 0.008 (− 0.003, 0.013)].

Conclusions
An overall increasing trend in the malaria incidence rate was observed irrespective of the implementation of LSM in the urban settings of Ethiopia, where An. stephensi has been found. Further investigations and validations of the incorporation of LSM into control activities are warranted.