bluuebunny/crossref_metadata_2025_split huggingface dataset:
Child and adolescent diabetes as a social medicine challenge in Poland
Authors: Konwant Dawid , Kurdyś-Bykowska Paulina , Armatys Aleksandra , Stencel-Gabriel Krystyna 
Published: December 2024

Introduction: Diabetes prevalence among children and adolescents poses a significant challenge to health care systems worldwide. Insufficient control of lifestyle diseases, including diabetes, can lead to an increased need for the use of outpatient services and hospitalization to stabilize the course of the disease.
Aim and methods: Demonstrate type 1 diabetes as an interdisciplinary problem of civilization diseases combining diagnosis and treatment along with the costs incurred by the health care system. Analysis of data on the amount of health services provided and costs for type 1 diabetes of children and adolescents in 2016-2019 in Poland was made.
Results: The number of pediatric patients who received services with the diagnosis E10 increased by 9.6% in the analyzed interval of years. The cost of health services provided increased by 27.2% during this period. The average annual cost of health services per patient in the last year of analysis (2019) increased by 16%.
Conclusions: Educational activities should be intensified among children and adolescents to increase proper diabetes self-management. This intervention will reduce the impact of diabetes, which results in increased use of health services to stabilize the disease and its effects.
Cross-Dock Trailer Scheduling with Workforce Constraints: A Dynamic Discretization Discovery Approach
Authors: Ojha Ritesh , Erera Alan 
Published: December 2024

Less-than-truckload (LTL) freight carriers operate consolidation networks that utilize cross-docking terminals to facilitate the transfer of freight between trailers and enhance trailer utilization. This research addresses the problem of determining an optimal schedule for unloading inbound trailers at specific unloading doors using teams of dock workers. The optimization objective is chosen to ensure that outbound trailers are loaded with minimal delay with respect to their target loading due dates. Formulating this problem, which is known to be NP-hard, using a typical time-expanded network often results in an excessively large mixed-integer programming (MIP) model. To overcome this challenge, we propose an exact dynamic discretization discovery (DDD) algorithm that iteratively solves MIPs formulated over partial networks. The algorithm employs a combination of a simple time discretization refinement strategy to progressively refine the partial network until a provably optimal solution is obtained. We demonstrate the effectiveness of the algorithm in solving problem instances representative of a large L-shaped cross-dock in Atlanta. The DDD algorithm outperforms solving the model formulated over a complete time-expanded network with a commercial solver in terms of both computational time and solution quality for practical instances with 180 trailers, 44 unloading doors, and 57 loading doors. Additionally, we compare the DDD algorithm with a state-of-the-art interval scheduling approach using instances from a previous study with a different objective function and additional constraints. The DDD algorithm is computationally faster for most of the small and medium instances and achieves competitive bounds for the larger instances. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2023.0406 .
Application of loaded graphene oxide biomaterials in the repair and treatment of bone defects
Authors: Xing Jinyi , Liu Shuzhong 
Published: December 2024

Addressing bone defects is a complex medical challenge that involves dealing with various skeletal conditions, including fractures, osteoporosis (OP), bone tumours, and bone infection defects. Despite the availability of multiple conventional treatments for these skeletal conditions, numerous limitations and unresolved issues persist. As a solution, advancements in biomedical materials have recently resulted in novel therapeutic concepts. As an emerging biomaterial for bone defect treatment, graphene oxide (GO) in particular has gained substantial attention from researchers due to its potential applications and prospects. In other words, GO scaffolds have demonstrated remarkable potential for bone defect treatment. Furthermore, GO-loaded biomaterials can promote osteoblast adhesion, proliferation, and differentiation while stimulating bone matrix deposition and formation. Given their favourable biocompatibility and osteoinductive capabilities, these materials offer a novel therapeutic avenue for bone tissue regeneration and repair. This comprehensive review systematically outlines GO scaffolds’ diverse roles and potential applications in bone defect treatment.Cite this article: Bone Joint Res 2024;13(12):725–740.
Acoustic Velocity of Rail Ties with Free and Fixed Boundary Conditions
Authors: Khademibami Laya , Shmulsky Rubin , Franca Frederico Jose Nistal , Irby Nathen , Senalik Christopher Adam , Fatemi Seyed Abolghasem 
Published: December 2024

Abstract
Nondestructive evaluation (NDE) is an effective technology that has been used for many decades to assess wood properties. However, NDE has not been well developed for in-service assessment of railroad ties of various wood species, grades, and boundary conditions. Acoustic velocity (AV) of railroad ties in free (on ballast) and fixed (packed with ballast and under static weight) boundary conditions was investigated herein. Overall, 60 new on-grade, 40 new off-grade, and 55 Grade-one (1) legacy ties were investigated. Ties were either oak/hickory or mixed hardwood. All ties were first measured in the free boundary condition and then packed with ballast, weighted, and measured in the fixed boundary condition. Ties were placed on ballast with approximately 10- to 11-cm (4- to 4.5-in.)-wide gaps between each. The AV that was measured after each tie was placed on the ballast (AVfree). Next, the ties were packed with ballast. Then a static weight, mimicking the load of rails, was placed on each tie and the AV was measured (AVfixed) with a Hitman HM220. All data were analyzed using three-way analysis of variance. The AV was higher for new on-grade versus new off-grade and legacy ties. The AV was higher for fixed versus free boundary condition. These results indicate that AV could be used to separate on-versus off-grade ties during production and that laboratory-scale AV technology could develop into an in-service technique.
Modeling cystic fibrosis patient prognosis: Nomograms to predict lung transplantation and survival prior to highly effective modular therapy
Authors: Piccorelli Annalisa V. , Nick Jerry A. 
Published: December 2024

Background
The duration of time a person with cystic fibrosis (pwCF) spends on the lung transplant waitlist is dependent on waitlist and post-transplant survival probabilities and can extend up to 2 years. Understanding the characteristics involved with lung transplant and survival prognoses may help guide decision making by the patient, the referring CF Center and the transplant team.

Methods
This study seeks to identify clinical predictors of lung transplant and survival of individuals with CF using 29,847 subjects from 2003–2014 entered in the Cystic Fibrosis Foundation Patient Registry (CFFPR).

Results
Predictors significant (p ≤ 0.05) in the final logistic regression model predicting probability of lung transplant/death were: FEV1 (% predicted), BMI, age of diagnosis, age, number of pulmonary exacerbations, race, sex, CF-related diabetes (CFRD), corticosteroid use, infections with B. cepacia, P. aeruginosa, S. aureus, MRSA, pancreatic enzyme use, insurance status, and consecutive ibuprofen use for at least 4 years. The final Cox regression model predicting time to lung transplant identified these predictors as significant FEV1 (% predicted), BMI, age of diagnosis, age, number of pulmonary exacerbations, race, sex, CF-related diabetes (CFRD), corticosteroid use, infections with B. cepacia, P. aeruginosa, S. aureus, MRSA, pancreatic enzyme use, and consecutive ibuprofen use for at least 4 years. The concordance indices were 0.89 and 0.92, respectively.

Conclusions
The models are translated into nomograms to simplify investigation of how various characteristics relate to lung transplant and survival prognosis individuals with CF not receiving highly effective CFTR modulator therapy.
A machine-learning model for prediction of Acinetobacter baumannii hospital acquired infection
Authors: Neuman Ido , Shvartser Leonid , Teppler Shmuel , Friedman Yehoshua , Levine Jacob J. , Kagan Ilya , Bishara Jihad , Kushinir Shiri , Singer Pierre 
Published: December 2024

Background
Acinetobacter baumanni infection is a leading cause of morbidity and mortality in the Intensive Care Unit (ICU). Early recognition of patients at risk for infection allows early proper treatment and is associated with improved outcomes. This study aimed to construct an innovative Machine Learning (ML) based prediction tool for Acinetobacter baumanni infection, among patients in the ICU, and to examine its robustness and predictive power.

Methods
For model development and internal validation, we used The Medical Information Mart for Intensive Care database (MIMIC) III data from 19,690 consecutive adult patients admitted between 2001 and 2012 at a Boston tertiary center ICU. For external validation, we used a different dataset from Rabin Medical Center (RMC, Israeli tertiary center) ICU, of 1,700 patients admitted between 2017 and 2021. After training on MIMIC cohorts, we adapted the algorithm from MIMIC to RMC and evaluated its discriminating power in terms of Area Under the Receiver Operating Curve (AUROC), sensitivity, specificity, Negative Predictive Value and Positive Predictive Value.

Results
The prediction model achieved AUROC = 0.624 (95% CI 0.604–0.647). The most significant predictors were (i) physiological parameters of cardio-respiratory function, such as carbon dioxide (CO2) levels and respiratory rate, (ii) metabolic disturbances such as lactate and acidosis (pH) and (iii) past administration of antibiotics.

Conclusions
Infection with Acinetobacter baumanni is more likely to occur in patients with respiratory failure and higher lactate levels, as well as patients who have used larger amounts of antibiotics. The accuracy of Acinetobacter prediction may be enhanced by future studies.
Neuroimaging markers and disability scales in multiple sclerosis: A systematic review and meta-analysis
Authors: Mirmosayyeb Omid , Yazdan Panah Mohammad , Mokary Yousef , Mohammadi Mohammad , Moases Ghaffary Elham , Shaygannejad Vahid , Weinstock-Guttman Bianca , Zivadinov Robert , Jakimovski Dejan 
Published: December 2024

Background
Multiple sclerosis (MS) is a central nervous system disorder marked by progressive neurological impairments. Magnetic resonance imaging (MRI) parameters are key paraclinical measures that play a crucial role in the diagnosis, prognosis, and monitoring of MS-related disability. This study aims to analyze and summarize the existing literature on the correlation between MRI parameters and disability in people with MS (pwMS).

Methods
The PubMed/MEDLINE, Embase, Scopus, and Web of Science databases were searched from inception to July 19, 2024, and a meta-analysis was carried out using R software version 4.4.0 and the random effects model used to determine the pooled correlation coefficient, with its 95% confidence interval (CI), between MRI measurements and disability scales.

Results
Among 5741 studies, 383 studies with 39707 pwMS were included. The meta-analysis demonstrated that Expanded Disability Status Scale (EDSS) had significant correlations with cervical cord volume (r = -0.51, 95% CI: -0.62 to -0.38, I2 = 0%, p-heterogeneity = 0.86, p-value<0.01), cortical lesion volume (r = 0.45, 95% CI: 0.36 to 0.53, I2 = 68%, p-heterogeneity<0.01, p-value<0.01), brain volume (r = -0.40, 95% CI: -0.47 to -0.33, I2 = 41%, p-heterogeneity = 0.05, p-value<0.05), and grey matter volume (GMV) (r = -0.36, 95% CI: -0.49 to -0.21, I2 = 0%, p-heterogeneity = 0.53, p-value<0.01), respectively.

Conclusion
This study offers evidence suggesting that cortical lesion volume, brain volume, GMV, and MRI measurements of the spinal cord may constitute reliable indicators for assessing disability in pwMS.
Cross-cultural adaptation and validation of the Chinese version of the PSS-QoL questionnaire
Authors: Zhou Yu , Zhuang Linli , He Xiaoqin , Xu Li , He Qi , Li Xuemei , Ye Yali 
Published: December 2024

Background
The quality of life(QoL) of patients with primary Sjögren’s syndrome(PSS) is affected by a variety of symptoms, and it is important to comprehensively assess the factors affecting patients’ QoL.The PSS-QoL is a specific tool for the assessment of patients’ QoL in the PSS. The purpose of this study was to cross-culturally adapt the PSS-QoL for the Chinese language,to establish a QoL assessment tool for PSS patients in Chinese culture and to test the reliability and validity of the PSS-QoL.

Methods
Our study period was from January 17, 2024 to June 15, 2024. The study was designed as a two-stage observational study. Double forward and backward translations of the PSS-QoL were performed for cultural adaptation to the Chinese language,and the specific steps included forward and backward translations, coordination, expert correspondence, small-sample surveys, and corrections to form the final draft of the Chinese version of the PSS-QoL. From January 29, 2024 to June 15, 2024,for the evaluation of psychometric properties, 135 patients with PSS completed the Chinese version of the PSS-QoL,Short Form-12(SF-12) and EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI).After 2 to 4 weeks,15 patients with PSS completed the Chinese version of the PSS-QoL for the second time.We used SPSS 26.0 software to statistically analyze the data, including item analysis and reliability and validity tests.

Results
The Chinese version of the PSS-QoL consists of 25 questions and can be divided into two main categories: physical (discomfort and dryness) and psychosocial. The mean score on the Chinese version of the PSS-QoL was 40.46±15.00. Among the 135 patients with PSS,92.60% were female, the mean (±SD) age was 52.76±12.74 years, and the disease duration was 5 (1.5, 9) years. There was good differentiation between the individual items and the Chinese version of the PSS-QoL,as the decision value of all the items ranged from -3.223 to -12.234 (p < 0.05), the correlation coefficient between the individual items and the whole questionnaire ranged from 0.315 to 0.730 (p < 0.05), the Chinese version of the PSS-QoL had good reliability and validity,as Cronbach’s α = 0.886, the Spearman-Brown coefficient was 0.782,the reliability of the individual items was 0.89,and the values of the I-CVI and S-CVI/AVE were all 1, indicating good psychometric properties. The construct validity between the Chinese version of the PSS-QoL and the ESSPRI was excellent (p = 0.506 ~0.687), and that between the PSS-QoL and the SF-12 was good(p = -0.464 ~ -0.673).

Conclusion
The Chinese version of the PSS-QoL possesses good reliability and validity, and all the indicies meet the metrics and satisfy the psychometrically acceptable range;therefore, it can be used as a reliable instrument for assessing the QoL of patients with PSS in China.
Delayed cord clamping: Perceptions, practices and influencers among the healthcare providers of selected healthcare facilities in Bangladesh
Authors: Jabeen Sabrina , Salam Shumona Sharmin , Gillespie Siobhan , Hasan Mehedi , Islam Sharmin , Chowdhury Anika Tasneem , Ameen Shafiqul , Balen Julie , Rahman Ahmed Ehsanur , Arifeen Shams El , Nahar Quamrun , Anumba Dilly OC 
Published: December 2024

Background
Umbilical cord clamping is a procedure of separating the newborn after birth with varying recommendations worldwide based on the timing of clamping. Although the benefits of delayed cord clamping (DCC) have been acknowledged, there is a lack of understanding regarding healthcare providers’ perceptions and practices, particularly in Bangladesh. This study aimed to explore the perceptions, practices, and influencers of DCC among healthcare providers in selected secondary-level healthcare facilities in Bangladesh.

Methods
This qualitative study was conducted at two public healthcare facilities. Purposive sampling was used to select 30 participants for in-depth and key-informant interviews and non-participatory observations for 13 deliveries were done. A thematic analysis approach was employed to identify emerging themes, and interpretive phenomenological analysis of the observations helped verify and contextualise the reported practices. Statistical software N-Vivo (Version-12, Denver) was used for data analysis.

Results
Healthcare providers perceived that cord clamping should occur after one to three minutes, primarily informed by international literature, maternal health training, or peer guidance. Providers recognised DCC’s benefits, such as enhanced bonding and reduced neonatal blood transfusions, and noted potential risks of early cord clamping like delayed adaptation and hypoxia. Observation of clamping practices revealed that most providers clamped after pulsation stopped or within three minutes, while caesarean sections often required immediate clamping. Variations existed in the number and type of clamps, with an absence of standardised guidelines. Influencing factors include the cultural impact of Traditional Birth Attendants (Dais), lack of formal training, clinical emergencies, and service delivery challenges such as high patient volumes and staff shortages. Peer learning was a major influencer of practices.

Conclusion
Despite having a perception regarding DCC, gaps were identified in the practice of healthcare providers. Addressing this gap and the identified influencers will require the involvement of healthcare workers, guidance developers and planners across policy and practice.
Fixed point results for generalized convex orbital Lipschitz operators
Authors: Zhou Mi , Li Guohui , Saleem Naeem , Popescu Ovidiu , Secelean Nicolae Adrian 
Published: December 2024

Abstract
Krasnoselskii’s iteration is a classical and important method for approximating the fixed point of an operator that satisfies certain conditions. Many authors have used this approach to obtain several famous fixed point theorems for different types of operators. It is well known that Kirk’s iteration can be seen as a generalization of Krasnoselskii’s iteration, in which the iterates are generated by a certain generalized averaged mapping. This approximation method is of great practical significance because the iterative formula contains more information related to the operator in question. The purpose of this study is to define weak

(

α

n

,

β

i

)

\left({\alpha }_{n},{\beta }_{i})

-convex orbital Lipschitz operators. These concepts not only extend the previously introduced Popescu-type convex orbital

(

λ
,
β

)

\left(\lambda ,\beta )

-Lipschitz operators in Fixed-point results for convex orbital operators, (Demonstr. Math. 56 (2023), 20220184), but also encompass many classical contractive operators. Popescu also proved a fixed point result for his proposed operator using the graphic contraction principle and obtained an approximation of the fixed point with Krasnoselskii’s iterates. To extend Popescu’s main results from Krasnoselskii’s iterative scheme to Kirk’s iterative scheme, several fixed point theorems are established, in which an appropriate Kirk’s iterative algorithm can be used to approximate the fixed point of a

k

k

-fold averaged mapping associated with our presented convex orbital Lipschitz operators. These results not only generalize, but also complement the existing results documented in the previous literature.
Is the Machine Surpassing Humans?
Authors: Barnard Marcel , Otte Wim 
Published: December 2024

Abstract
This article explores the relationship between large language models (LLMs) and humans as well as its impact on practical theology, more specifically on ritual-liturgical studies. We show how LLMs question human exceptionalism in the realms of language, creativity, grounding, and meta-representation. Subsequently, we discuss the assumed role of language in understanding who we are as humans. LLMs call for a reappraisal of Saussure’s structuralism. We demonstrate how in LLMs, structuralism converges with hermeneutic approaches to language. We speculate on the immanent interpenetration of LLMs and liturgical practices from the perspective of a revisiting of structuralism. Finally, we offer some perspectives on the future of LLMs and liturgy.
A 2D velocity field computation using multi-dimensional InSAR: a case study of the Abu-Dabbab area in Egypt
Authors: Abo Gharbia Alshimaa Y. , Saleh Mohamed , Gomaa Ahmed , Mousa Ashraf Elkutb , Hassan Moatamad R. , Abbas Ibrahim Atiatallah 
Published: December 2024

Abstract
In this paper, the surface deformation of Abu-Dabbab area in Egypt is analyzed. This area is appealing for a variety of investments and tourism because of its temperate climate and pristine surroundings. The ascending Sentinal-1A and Sentinal-1B data of 204 scenes from September, 2016 to December, 2021 and the descending Sentinal-1A data of 116 scenes from May, 2017 to December, 2021 are used for analysis. The surface deformation results in time series that are extracted by the small baseline subset interferometric synthetic aperture radar (SBAS-InSAR) approach. According to the InSAR monitoring data, Abu-Dabbab’s overall deformation rate is between approximately −10 mm/yr, 10 mm/yr and approximately −3 mm/yr, 3 mm/yr for vertical v

U
and horizontal (East-West) v

E
velocity respectively. These results indicate that the area is in a stable state. Field research confirms the validity of the SBAS-InSAR approach for surface deformation monitoring. By using Global Positioning System (GPS) techniques, the crustal deformation data are collected in this area. The more exact positions of the GPS station have been obtained by the recording, processing, and adjustment of GPS measurements. Within the same timeframe, there was a correlation between the GPS measurements of Marsa Alam’s station (MARS) and the InSAR results. The MARS station location’s estimated vertical and horizontal (East-West) measurements were 1.5 ± 0.5 mm/yr and −1.7 ± 0.6 mm/yr, respectively, with a 95 % confidence level from GPS data. The decomposition of the descending and ascending LOS tracks of the MARS GPS station yielded a vertical component and a horizontal component of 2.01 ± 0.4 mm/yr and −2.42 ± 0.7 mm/yr, respectively. The factors affecting the development of geological disasters are also discussed.
The assessment of 5-aminolevulinic acid photodynamic therapy in glioblastomas
Authors: Aebisher David , Mytych Wiktoria , Łoś Aleksandra , Dynarowicz Klaudia , Myśliwiec Angelika , Bartusik-Aebisher Dorota 
Published: December 2024

Abstract
Photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) has emerged as a promising strategy in the treatment of various cancers, particularly gliomas. The biosynthesis of prodrug 5-ALA plays a pivotal role in the heme production pathway of Protoporphyrin IX (PpIX), and understanding this molecular process offers significant insights into cellular physiology and therapeutic potential. This review highlights the clinical applications of 5-ALA in PDT, underscoring the translational impact of foundational research on its biosynthesis. The search, performed on PubMed and Web of Science, included both in vivo clinical studies and in vitro preclinical studies. The findings of this review emphasize the expanding potential for novel therapeutic strategies, driven by an enhanced understanding of 5-ALA biosynthesis and its application in PDT, offering a promising future for medical advancements in cancer treatment.