bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental views on attending neonatal intensive care ward rounds
Authors: Caldwell Claire , MacBean Victoria , Hunt Katie , Greenough Anne 
Published: April 2019

ObjectivesTo ascertain parental views regarding taking part in neonatal unit ward rounds.DesignA service evaluation project.SettingTertiary neonatal intensive care unit.PatientsParent(s) of infants receiving care on the neonatal unit.InterventionsStructured interviews conducted at the cot side.Main outcome measuresParents were asked if they knew when ward rounds occurred, whether they had attended ward rounds and if they had not what were the factors inhibiting them from doing so, their experience of attending ward rounds and whether they were concerned about issues of confidentiality.Results23 of 24 consecutive parents agreed to be interviewed. The median age of their infants was 14 (range 3 – 123) days when they were interviewed. Eighty-five per cent were able to identify when a nursing handover or doctor’s ward round occurred. Seventy-five per cent of parents had attended at least one ward round and the median score in terms of usefulness was 5 out of 5. Reasons for not attending included time and cost to travel to the unit, their partners were working and having other children. Parents volunteered that the nurses proactively updated them as soon as they arrived, hence making regular attendance less important. Regarding confidentiality, 85% were not concerned if other people overheard information about their baby, unless the news was bad.ConclusionsParents recognised the value of attending ward rounds and generally found it a positive experience, but emphasised limitations on their ability to attend.
Genetic correlates of wall shear stress in a patient-specific 3D-printed cerebral aneurysm model
Authors: Levitt Michael R , Mandrycky Christian , Abel Ashley , Kelly Cory M , Levy Samuel , Chivukula Venkat K , Zheng Ying , Aliseda Alberto , Kim Louis J 
Published: April 2019

ObjectivesTo study the correlation between wall shear stress and endothelial cell expression in a patient-specific, three-dimensional (3D)-printed model of a cerebral aneurysm.Materials and methodsA 3D-printed model of a cerebral aneurysm was created from a patient’s angiogram. After populating the model with human endothelial cells, it was exposed to media under flow for 24 hours. Endothelial cell morphology was characterized in five regions of the 3D-printed model using confocal microscopy. Endothelial cells were then harvested from distinct regions of the 3D-printed model for mRNA collection and gene analysis via quantitative polymerase chain reaction (qPCR.) Cell morphology and mRNA measurement were correlated with computational fluid dynamics simulations.ResultsThe model was successfully populated with endothelial cells, which survived under flow for 24 hours. Endothelial morphology showed alignment with flow in the proximal and distal parent vessel and aneurysm neck, but disorganization in the aneurysm dome. Genetic analysis of endothelial mRNA expression in the aneurysm dome and distal parent vessel was compared with the proximal parent vessels. ADAMTS-1 and NOS3 were downregulated in the aneurysm dome, while GJA4 was upregulated in the distal parent vessel. Disorganized morphology and decreased ADAMTS-1 and NOS3 expression correlated with areas of substantially lower wall shear stress and wall shear stress gradient in computational fluid dynamics simulations.ConclusionsCreating 3D-printed models of patient-specific cerebral aneurysms populated with human endothelial cells is feasible. Analysis of these cells after exposure to flow demonstrates differences in both cell morphology and genetic expression, which correlate with areas of differential hemodynamic stress.
Early post-Humanitarian Device Exemption experience with the Neuroform Atlas stent
Authors: Tsai Jenny P , Hardman Julian , Moore Nina Z , Hussain M Shazam , Bain Mark D , Rasmussen Peter A , Masaryk Thomas J , Elgabaly Mohammed H , Sheikhi Lila , Toth Gabor 
Published: April 2019

IntroductionThe low-profile Neuroform Atlas stent received FDA Humanitarian Device Exemption status (HDE) in January 2018 for stent-assisted coil embolization of wide-necked saccular aneurysms. We review and report our results with the Atlas stent in our institution within the first year after its HDE approval.MethodsOur retrospective chart review identified patients treated with the Atlas stent. We analyzed the patient demographics, aneurysm characteristics, stent parameters and configuration, complications, angiographic, and clinical outcomes at discharge.ResultsFrom January to December 2018, 76 Atlas stents were deployed in 58 patients (average 1.3 stents/patient). Median patient age was 63.5 (IQR 56–71) years. Fifty-six (96.6%) patients had elective embolization of unruptured aneurysms, while two (3.4%) patients underwent embolization of a ruptured aneurysm within 2 weeks of subarachnoid hemorrhage. Forty (69.0%) patients were treated with a single stent, 15 (25.9%) with a Y-stent, and three (5.2%) with X-stent configuration. All stent deployments were technically successful. Most stents (82.9%) were the smallest 3 mm diameter devices. Procedural complications included transient stent-associated thrombosis in three (5.2%) patients and aneurysm rupture in one (1.7%). None had distal embolization, associated cerebral infarction, or permanent neurological deficits. Immediate Raymond–Roy 1 occlusion was achieved in 41 (70.7%) patients. Median hospital length of stay for elective aneurysm embolization was 1 day. Excellent outcomes with median National Institute of Health Stroke Scale score 0 (IQR 0–0) and modified Rankin Score 0 (IQR 0–1) were seen for elective patients at discharge.ConclusionThe Neuroform Atlas stent provided a reliable technical and safety profile for the treatment of intracranial wide-neck aneurysms. Further experience is needed to determine long-term durability and safety of this device.
The effect of CaO/SiO2 and B2O3 on the sintering contraction behaviors of CaO-B2O3-SiO2 glass-ceramics
Authors: Yan Tingnan , Zhang Weijun , Mao Haijun , Chen Xingyu , Bai Shuxin 
Published: April 2019

We investigate the effect of CaO/SiO2 (molar ratio) and B2O3 content on the structure and sintering contraction behaviors of Calcium borosilicate (CaO–B2O3–SiO2, CBS) glass-ceramic through the dilatometer and the Fourier transform infrared (FTIR) spectroscopy. The results show that the sintering-shrinkage of CBS glass-ceramics is promoted dramatically with the increase of CaO/SiO2 to 1.14, and then keeps nearly constant as the CaO/SiO2 further increases. This phenomenon is correlated with the degree of polymerization (DOP) of the Si–O network structure modulated by the CaO/SiO2, additionally, two sintering shrinkage peaks, corresponding to two-step depolymerization, are detected in the sintering-shrinkage curves of the CBS glass-ceramic as the B2O3 content is elevated to 13.6 mol%. Meanwhile, the shrinking rate of CBS glass-ceramics is increased from 8 × 10[Formula: see text] to 37 × 10[Formula: see text] min[Formula: see text] and the softening point is decreased from 736[Formula: see text]C to 691[Formula: see text]C with the increase of B2O3 content from 6.8 to 20.8 mol⋅%. This is due to the introduction of BO3 trihedral into Si–O–Si three-dimensional structure, which greatly reduces the uniformity and symmetry of the networks, inducing the decrease of the strength for the whole Si–O–Si network structures. The results obtained in this paper reveal the relationship between the glass structure and sintering behavior of the CBS glass-ceramic, which gives an avenue to improve its physical properties.
Effect of SESAM on continuous-wave multi-wavelength fiber ring-cavity laser with semiconductor optical amplifier
Authors: Luo Min , Cao Wei , Chen Haiyan 
Published: April 2019

The effect of semiconductor saturable absorber mirror (SESAM) on continuous-wave multi-wavelength fiber ring-cavity laser with semiconductor optical amplifier (SOA) is experimentally demonstrated. The evolutionary process of multi-wavelength oscillation and the decrease of oscillating mode number caused by an SESAM are discussed. It’s found that the free oscillating mode number of the multi-wavelength fiber ring-cavity laser with SOA can be upto three, and the lasing wavelengths are 1573.8 nm, 1578.09 nm and 1582.37 nm, respectively. When a SESAM is inserted in the fiber ring-cavity, it narrows the amplified spontaneous emission (ASE) spectrum of the SOA, and the oscillating mode number of the multi-wavelength fiber ring-cavity lasers with SOA decreases to two, a stable dual-wavelength lasing at 1560.91 nm and 1564.12 nm is obtained.
Min-/Max-Volume Roofs Induced by Bisector Graphs of Polygonal Footprints of Buildings
Authors: Eder Günther , Held Martin , Palfrader Peter 
Published: April 2019

Piecewise-linear terrains (“roofs”) over simple polygons were first studied by Aichholzer et al. (J. UCS 1995) in their work on straight skeletons of polygons. We show how to construct a roof over the polygonal footprint of a building that has minimum or maximum volume among all roofs that drain water. Our algorithm for computing such a roof extends the standard plane-sweep approach known from the theory of straight skeletons by additional events. For both types of roofs our algorithm runs in [Formula: see text] time for a simple polygon with [Formula: see text] vertices.
Geochemical discrimination and petrogenetic affinities of dykes intruding the Ladakh batholith, NW India
Authors: Heri A. R. , Bahl J. , Villa I. M. 
Published: April 2019

Abstract
Eocene dykes extending over 50 km along the southern margin of the Ladakh batholith (NW India) fall into two main groups showing different orientations, as well as different isotope and trace element geochemistry. Both dyke families formed in the same tectonic setting over a time span of approximately 4 Ma. However, each family is far from monolithic, and therefore we tested several statistical approaches to identify geochemical subgroups from rare earth element (REE) data and relate them to magmatogenetic processes.
Hierarchical clustering and multidimensional scaling calculate similarities/dissimilarities among individuals of a population. Both statistical tools, when applied to the Ladakh dykes, reflect the east–west dichotomy. However, detailed quantification of the resulting grouping varies according to input data. Normalization to chondrites yields slightly different groupings from unnormalized concentration data. Population internal REE normalization provides the most accurate grouping, as revealed by the fact that multiple samples from the same dyke are assigned the closest relatedness. Independently from normalization, east–west dichotomy is mirrored by marked differences in the degree of crustal assimilation and magma evolution, pointing to kilometre-scale geological heterogeneity. Finally, dykes intruding the Ladakh batholith 150 km SE of the present samples are geochemically similar, but cluster as a distinct group.
A novel method optimizing the normalization of cardiac parameters in small animal models: the importance of dimensional indexing
Authors: Hagdorn Quint A. J. , Bossers Guido P. L. , Koop Anne-Marie C. , Piek Arnold , Eijgenraam Tim R. , van der Feen Diederik E. , Silljé Herman H. W. , de Boer Rudolf A. , Berger Rolf M. F. 
Published: April 2019

For indexing cardiac measures in small animal models, tibia length (TL) is a recommended surrogate for body weight (BW) that aims to avoid biases because of disease-induced BW changes. However, we question if indexing by TL is mathematically correct. This study aimed to investigate the relation between TL and BW, heart weight, ventricular weights, and left ventricular diameter to optimize the current common practice of indexing cardiac parameters in small animal models. In 29 healthy Wistar rats (age 5–34 wk) and 116 healthy Black 6 mice (age 3–17 wk), BW appeared to scale nonlinearly to TL1 but linearly to TL3. Formulas for indexing cardiac weights were derived. To illustrate the effects of indexing, cardiac weights between the 50% with highest BW and the 50% with lowest BW were compared. The nonindexed cardiac weights differed significantly between groups, as could be expected ( P < 0.001). However, after indexing by TL1, indexed cardiac weights remained significantly different between groups ( P < 0.001). With the derived formulas for indexing, indexed cardiac weights were similar between groups. In healthy rats and mice, BW and heart weights scale linearly to TL3. This indicates that not TL1 but TL3 is the optimal surrogate for BW. New formulas for indexing heart weight and isolated ventricular weights are provided, and we propose a concept in which cardiac parameters should not all be indexed to the same measure but one-dimensional measures to BW1/3 or TL1, two-dimensional measures to BW2/3 or TL2, and three-dimensional measures to BW or TL3. NEW & NOTEWORTHY In healthy rats and mice, body weight (BW) scales linearly to tibia length (TL) to the power of three (TL3). This indicates that for indexing cardiac parameters, not TL1 but TL3 is the optimal surrogate for BW. New formulas for indexing heart weight and isolated ventricular weights are provided, and we propose a concept of dimensionally consistent indexing. This concept is proposed to be widely applied in small animal experiments.
Left ventricular and proximal aorta coupling in magnetic resonance imaging: aging together?
Authors: Redheuil Alban , Kachenoura Nadjia , Bollache Emilie , Yu Wen-Chung , Opdahl Anders , Decesare Alain , Mousseaux Elie , Bluemke David , Lima Joao A. C. 
Published: April 2019

The importance of aorta-ventricular coupling in cardiovascular disease is recognized but underestimated. The contribution of the age-related decline in ascending aortic function compared with characteristic impedance and total peripheral resistance on left ventricular function and remodeling is poorly studied. Our aim was to evaluate the relation of proximal aortic distensibility and impedance with left ventricular geometry and function in asymptomatic individuals. We prospectively studied 100 subjects (47 men, 53 women, age: 20–84 yr). Aortic strain, distensibility, arch pulse wave velocity, characteristic impedance ( Zc), total peripheral resistance, left ventricular (LV) volumes and mass, wall stress, and peak global circumferential myocardial strain and strain rates were determined by MRI. Central pressures were measured from tonometry. Ea/ Ev, an index of vascular-ventricular coupling, and LV wall stress were preserved across age- or aortic-stiffness-stratified groups. Static and pulsatile components of aortic load were differentially associated with age. Increased total vascular resistance was associated with decreased LV strain and increased concentric remodeling [ratio of LV mass to end-diastolic volume (M/V ratio)] in all individuals. In younger individuals (<45 yr), aortic distensibility was related to LV strain and concentric remodeling (M/V ratio), whereas Zc was related to LV strain and concentric remodeling (M/V ratio) in older individuals (>45 yr). Early age-related stiffening of the ascending aorta is a component of LV afterload subsequently associated with increased aortic impedance and alterations in LV geometry, namely concentric remodeling, decreased myocardial strain, and increased stroke work such that LV wall stress and arterial-ventricular coupling are preserved. NEW & NOTEWORTHY Local flow and deformation can both be assessed with high precision noninvasively in the ascending aorta using MRI. Combined with central pressure measurement, they provide distensibility and impedance and simultaneous reference assessment of left ventricular deformation and geometry, hence a comprehensive evaluation of arterial-ventricular coupling to study physiology and disease.
High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma
Authors: Wang Sarah , Hwang Elizabeth E. , Guha Rajarshi , O'Neill Allison F. , Melong Nicole , Veinotte Chansey J. , Conway Saur Amy , Wuerthele Kellsey , Shen Min , McKnight Crystal , Alexe Gabriela , Lemieux Madeleine E. , Wang Amy , Hughes Emma , Xu Xin , Boxer Matthew B. , Hall Matthew D. , Kung Andrew , Berman Jason N. , Davis Mindy I. , Stegmaier Kimberly , Crompton Brian D. 
Published: April 2019

Abstract

Purpose:
Ewing sarcoma is an aggressive solid tumor malignancy of childhood. Although current treatment regimens cure approximately 70% of patients with localized disease, they are ineffective for most patients with metastases or relapse. New treatment combinations are necessary for these patients.

Experimental Design:
Ewing sarcoma cells are dependent on focal adhesion kinase (FAK) for growth. To identify candidate treatment combinations for Ewing sarcoma, we performed a small-molecule library screen to identify compounds synergistic with FAK inhibitors in impairing Ewing cell growth. The activity of a top-scoring class of compounds was then validated across multiple Ewing cell lines in vitro and in multiple xenograft models of Ewing sarcoma.

Results:
Numerous Aurora kinase inhibitors scored as synergistic with FAK inhibition in this screen. We found that Aurora kinase B inhibitors were synergistic across a larger range of concentrations than Aurora kinase A inhibitors when combined with FAK inhibitors in multiple Ewing cell lines. The combination of AZD-1152, an Aurora kinase B–selective inhibitor, and PF-562271 or VS-4718, FAK-selective inhibitors, induced apoptosis in Ewing sarcoma cells at concentrations that had minimal effects on survival when cells were treated with either drug alone. We also found that the combination significantly impaired tumor progression in multiple xenograft models of Ewing sarcoma.

Conclusions:
FAK and Aurora kinase B inhibitors synergistically impair Ewing sarcoma cell viability and significantly inhibit tumor progression. This study provides preclinical support for the consideration of a clinical trial testing the safety and efficacy of this combination for patients with Ewing sarcoma.
Activity and Safety of Palbociclib in Patients with Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and Sunitinib: A Biomarker-driven Phase II Study
Authors: Toulmonde Maud , Blay Jean-Yves , Bouche Olivier , Mir Olivier , Penel Nicolas , Isambert Nicolas , Duffaud Florence , Bompas Emmanuelle , Esnaud Thomas , Boidot Romain , Geneste Damien , Ghiringhelli François , Lucchesi Carlo , Bellera Carine A. , Le Loarer François , Italiano Antoine 
Published: April 2019

Abstract

Purpose:
CDKN2A loss is frequent in gastrointestinal stromal tumors (GISTs) and associated with aggressive outcome. Palbociclib is a CDK4 inhibitor with preclinical antitumor efficacy in tumors with P16/CDKN2A loss.

Patients and Methods:
This is a multicenter single-arm phase II clinical trial assessing safety and efficacy of palbociclib in patients with advanced GIST bearing CDKN2A gene loss. Adults with unresectable locally advanced or metastatic, refractory to at least imatinib and sunitinib, measurable and documented progressive disease (PD) as per RECIST 1.1, and CDKN2A deletion centrally assessed were eligible. Patients received palbociclib 125 mg orally daily on a 21 days on/7 days off dosing schedule, until PD or unacceptable toxicity. The primary endpoint was 4-month non-PD rate according to RECIST 1.1.

Results:
As of May 2017, 71 patients had been included in the study, and 29 patients (40.3%) met the molecular eligibility requirement. Twenty-five patients (86.2%) had grade 1–2 adverse events (AEs) and 12 patients (41.4%) grade 3–4 AEs possibly related to the drug. The planned interim statistical analysis performed after central histologic and radiological review showed that 19 (86.4%) out of the first 22 evaluable patients had PD at 4 months. CDKN2A status had no impact either on overall survival or outcome on previous standard lines of treatment. Translational analysis suggested upregulation of CCNE1 or downregulation of CDKN1A/P21 or LRRC3B as potential mechanisms of resistance.

Conclusions:
Palbociclib has no significant clinical activity as a single agent in P16/CDKN2A–deleted GIST refractory to imatinib and sunitinib.
A Pilot Study of Liposomal Doxorubicin Combined with Bevacizumab followed by Bevacizumab Monotherapy in Patients with Advanced Kaposi Sarcoma
Authors: Ramaswami Ramya , Uldrick Thomas S. , Polizzotto Mark N. , Wyvill Kathleen M. , Goncalves Priscila , Widell Anaida , Lurain Kathryn , Steinberg Seth M. , Figg William Douglas , Tosato Giovanna , Whitby Denise , Yarchoan Robert 
Published: April 2019

Abstract

Purpose:
VEGF-A is important in the pathogenesis of Kaposi sarcoma, and bevacizumab has a response rate of 31%. We explored the combination of bevacizumab with liposomal doxorubicin in patients with Kaposi sarcoma.

Patients and Methods:
Patients with Kaposi sarcoma requiring systemic therapy were enrolled in one of two cohorts. Cohort 1 included patients with human immunodeficiency virus (HIV)-negative Kaposi sarcoma or with HIV-associated Kaposi sarcoma who would not be expected to respond to antiretroviral therapy (ART) alone (i.e., either stable or progressive Kaposi sarcoma on ART). Cohort 2 included all other patients with HIV-associated Kaposi sarcoma. Patients were treated with six cycles of liposomal doxorubicin with bevacizumab every 3 weeks followed by up to 11 cycles of bevacizumab alone.

Results:
Sixteen patients were enrolled: 10 (two HIV negative) in cohort 1 and six in cohort 2. Fourteen patients had advanced disease (AIDS Clinical Trials Group T1). Overall response rate (complete and partial responses) was 56% [80% confidence interval (CI), 38%–74%] for all patients and were similar in the two cohorts. Median progression-free survival was 6.9 months (95% CI, 4.5 months–not estimable). Grade 3 and 4 adverse events attributed to therapy included hypertension (n = 5), neutropenia (n = 6), gastrointestinal hemorrhage (n = 1), and cerebral ischemia (n = 1). There was a significant decrease in VEGF-A levels from baseline to the end of six cycles of combination therapy.

Conclusions:
Pegylated liposomal doxorubicin in combination with bevacizumab has activity in advanced Kaposi sarcoma, but it is unclear whether the combination yields better outcomes than liposomal doxorubicin used alone.