bluuebunny/crossref_metadata_2025_split huggingface dataset:
MIPSS70+ v2.0 predicts long-term survival in myelofibrosis after allogeneic HCT with the Flu/Mel conditioning regimen
Authors: Ali Haris , Aldoss Ibrahim , Yang Dongyun , Mokhtari Sally , Khaled Samer , Aribi Ahmed , Afkhami Michelle , Al Malki Monzr M. , Cao Thai , Mei Matthew , O’Donnell Margaret , Salhotra Amandeep , Pullarkat Vinod , Yang Lixin , Stein Anthony S. , Marcucci Guido , Forman Stephen J. , Nakamura Ryotaro , Pillai Raju , Snyder David 
Published: January 2019

Abstract
Although allogeneic hematopoietic cell transplantation (allo-HCT) is the only curative treatment for myelofibrosis (MF), data are limited on how molecular markers predict transplantation outcomes. We retrospectively evaluated transplantation outcomes of 110 consecutive MF patients who underwent allo-HCT with a fludarabine/melphalan (Flu/Mel) conditioning regimen at our center and assessed the impact of molecular markers on outcomes based on a 72-gene next-generation sequencing panel and Mutation-Enhanced International Prognostic Scoring System 70+ v2.0 (MIPSS70+ v2.0). With a median follow-up of 63.7 months, the 5-year overall survival (OS) rate was 65% and the nonrelapse mortality (NRM) rate was 17%. In mutational analysis, JAK2 V617F and ASXL1 mutations were the most common. By univariable analysis, higher Dynamic International Prognostic Scoring System scores, unrelated donor type, and very-high-risk cytogenetics were significantly associated with lower OS. Only CBL mutations were significantly associated with lower OS (hazard ratio [HR], 2.64; P = .032) and increased NRM (HR, 3.68; P = .004) after allo-HCT, but CALR, ASXL1, and IDH mutations did not have an impact on transplantation outcomes. Patient classification per MIPSS70 showed worse OS for high-risk (HR, 0.49; P = .039) compared with intermediate-risk patients. Classification per MIPSS70+ v2.0 demonstrated better OS when intermediate-risk patients were compared with high-risk patients (HR, 0.291) and much lower OS when very-high-risk patients were compared with high-risk patients (HR, 5.05; P ≤ .001). In summary, we present one of the largest single-center experiences of Flu/Mel-based allo-HCT, demonstrating that revised cytogenetic changes and MIPSS70+ v2.0 score predict transplantation outcomes, and thus can better inform physicians and patients in making decisions about allo-HCT.
A common arthropod from the Late Ordovician Big Hill Lagerstätte (Michigan) reveals an unexpected ecological diversity within Chasmataspidida
Authors: Lamsdell James C. , Gunderson Gerald O. , Meyer Ronald C. 
Published: January 2019

AbstractBackgroundChasmataspidids are a rare group of chelicerate arthropods known from 12 species assigned to ten genera, with a geologic range extending from the Ordovician to the Devonian. The Late Ordovician (Richmondian) fauna of the Big Hill Lagerstätte includes a new species of chasmataspidid represented by 55 specimens. This taxon is only the second chasmataspidid described from the Ordovician and preserves morphological details unknown from any of the previously described species.ResultsThe new chasmataspidid species is described asHoplitaspis hiawathaigen. et sp. nov.. Comparison with all other known chasmataspidids indicates thatHoplitaspisoccupies an intermediate morphological position between the OrdovicianChasmataspisand the Silurian-Devonian diploaspidids. While the modification of appendage VI into a broad swimming paddle alliesHoplitaspisto the Diploaspididae, the paddle lacks the anterior ‘podomere 7a’ found in other diploaspidids and shows evidence of having been derived from aChasmataspis-like chelate appendage. Other details, such as the large body size and degree of expression of the first tergite, show clear affinities withChasmataspis, providing strong support for chasmataspidid monophyly.ConclusionsThe large body size and well-developed appendage armature ofHoplitaspisreveals that chasmataspidids occupied a greater breadth of ecological roles than previously thought, with the abundance of available specimens indicating thatHoplitaspiswas an important component of the local community. The miniaturization and ecological limiting of diploaspidids potentially coincides with the major radiation of eurypterids and may suggest some degree of competition between the two groups. The geographic distribution of chasmataspidid species suggests the group may have originated in Laurentia and migrated to the paleocontinents of Baltica and Siberia as tectonic processes drew the paleocontinents into close proximity.
Sole Reconstruction Using Anterolateral Thigh Free Flap: A Review of 4 Cases
Authors: Atmodiwirjo Parintosa , Sandhi Afriyanti 
Published: January 2019

Background: The ideal technique for sole reconstruction should meet such requisite as a durable and comfortable weight-bearing surface, solid anchoring to deep tissue for resistance to shear force and adequate protective sensation. The anterolateral thigh (ALT) perforator free flap provides a large, pliable skin island and sufficient bulk, allowing three-dimensional tailoring to complex defects. The present article is about our experience of sole reconstruction ALT perforator free flap.
Patient and Method: Total of 4 flaps in the foot defects was performed in February 2009 to December 2012. We reconstructed soft tissue defects in the sole using ALT free flaps, the complications, aesthetic and function results were monitored.
Result: ALT perforator free flap provided stable and durable long-term wound cover in all patients, resulting in early rehabilitation and function outcomes were completely achieved. Complications were few and manageable in all cases.
Summary: ALT perforator free flap has become common procedure in many centers around the world. The numerous advantages include stable wound coverage; improve aesthetic and functional outcomes, and minimal donor site morbidity. In our experiences, we found that the use of ALT perforator free flap in sole defect reconstruction, to be technically affordable, reliable and have resulted in excellent outcomes.
Reconstructive Rhinoplasty: New Technique of Central Cartilaginous Support
Authors: Sajid Muhammad , Bhatti Zahid , Nazeer Aisha , Mughese Sadia , Tayyaba Tayyaba , Amin Mohammad Mughese 
Published: January 2019

Background: Honour amputation is a common cause of nose amputation in Pakistan, especially in dahawalpur region. Skeletal support is always a problem in major nasal amputations. It needs multiple delays and extra support later on, with all traditional techniques.

Patient and Method: We reported three cases of amputation of the nose. We used sliding septal technique to reconstruct the central cartilaginous support of the nose. In this technique we used the remaining septum as a free graft. Ten patients were treated with this technique with excellent results. Nasal lining was provided either with septal artery mucosal flap or with nasolabial flap. Forehead flap was the only flap to provide external cover. Nostril rim were grafted with trimmed choncial cartilage primarily. In three patients debulking procedures were done later on , but no skeletal procedures.
Result: This technique has given an excellent skeletal support and a nice tip projection with no delays or extra support later on. Patient satisfaction rate was 100%.
Summary: Sliding septal technique is a very reliables, cost effective technique. It provides an excellent tip support in a single procedure, without sacrificing other precious material like rib or bone.
Compressed Edge Spectrum Sensing: Extensions and practical considerations
Authors: Beck Edgar , Bockelmann Carsten , Dekorsy Armin 
Published: January 2019

Abstract
Nowadays, spectrum in industrial radio systems is already overoccupied. Therefore, future Industry 4.0 applications require coexistence management of different wireless communication systems. For identification of active systems, we propose Compressed Edge Spectrum Sensing (CESS). Here, we focus on practical aspects and show that the sampling rate can still be highly reduced.
GenCoNet – A Graph Database for the Analysis of Comorbidities by Gene Networks
Authors: Shoshi Alban , Hofestädt Ralf , Zolotareva Olga , Friedrichs Marcel , Maier Alex , Ivanisenko Vladimir A. , Dosenko Victor E. , Bragina Elena Yu 
Published: January 2019

Abstract
The prevalence of comorbid diseases poses a major health issue for millions of people worldwide and an enormous socio-economic burden for society. The molecular mechanisms for the development of comorbidities need to be investigated. For this purpose, a workflow system was developed to aggregate data on biomedical entities from heterogeneous data sources. The process of integrating and merging all data sources of the workflow system was implemented as a semi-automatic pipeline that provides the import, fusion, and analysis of the highly connected biomedical data in a Neo4j database GenCoNet. As a starting point, data on the common comorbid diseases essential hypertension and bronchial asthma was integrated. GenCoNet (https://genconet.kalis-amts.de) is a curated database that provides a better understanding of hereditary bases of comorbidities.
Modality in Spanish Sign Language (LSE) revisited: a functional account
Authors: Salazar-García Ventura 
Published: January 2019

AbstractThis paper provides an analysis of modality in Spanish Sign Language (Lengua de Signos Española: LSE) from a functional perspective. Following FDG assumptions, scope will be the basic criterion in delineating modal subtypes. Four representational layers are taken into account: Propositional Content, Episode, State-of-Affairs, and Configurational Property. This study highlights that LSE offers an extensive sample of manual items (with a variable degree of grammaticalization) that enable the efficient expression of a wide range of modal contents: epistemic, deontic, volitive, and facultative. LSE is thus fully congruent with oral languages (OLs) in this domain.
DST-deactivation of nickel-63 nitrate
Authors: Cardone Fabio , Albertini Gianni , Bassani Domenico , Cherubini Giovanni , Petrucci Andrea , Rosada Alberto 
Published: January 2019

Abstract
Recent theoretical and experimental results, based on an extension of the Einstein theory of relativity, show that nuclear reactions of a new type can occur. In this framework, the feasibility of the deactivation of radionuclides is investigated. This paper reports the deactivation of nickel nitrate made of radioactive Nickel-63 in nitric acid by using ultrasounds. From the applicative point of view, it is a more realistic system then the previously considered thorium, not only because the molecule and the system are more complex but also because the problems related to the high corrosion and radioactivity have been treated at the same time, thus miming realistic situations like those of deactivation of nuclear waste.
Experimental and Numerical Investigation of Residual Stress in Coatings on Steel
Authors: Ojha Sarvesh , Thakare J. G. , Giri A. , Pandey Chandan , Mahapatra M. M. , Mulik R. S. 
Published: January 2019

Abstract
In the present work, an alumina–titania (13 %) coating has been deposited by the air plasma spray process on a mild steel substrate by preheating the substrate to different temperatures. Coating thickness was measured by a scanning electron microscope, the hardness of coatings was measured, and morphology was also checked. The crack compliance technique has been used to determine the residual stress, as it is a very simple method, and also, it is compatible with conventional machining equipment and wire electric discharge machining equipment. Specimens were cut by the diamond cutter up to certain depth in microns, and the strain relieved was recorded. For finding out the residual stress, these recorded values of strain have been used by doing a finite element analysis (FEA) using the ANSYS 15.0 (Ansys, Inc., Canonsburg, PA) software. For validation of the model, uniaxial tension was applied on a sample by using the INSTRON universal testing machine (Instron Inc., Norwood, MA), and strain values at both the coating side and the substrate side were recorded and matched with the model under the same value of the load. After verifying the model, an equation has been developed using the Minitab software (Minitab Inc, Bengaluru, India), and the strains previously recorded were used as an input to the equation obtained, and the value of residual stress was calculated. The maximum value of residual stress was found at the coating–substrate interface, and the values of residual stress for sample preheated at 250°C, 200°C, and 150°C were found to be compressive, with the magnitude of −176.28 MPa, −243.54 MPa, and −255.42 MPa, respectively.
Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache
Authors: Noseda Rodrigo , Melo-Carrillo Agustin , Nir Rony-Reuven , Strassman Andrew M. , Burstein Rami 
Published: January 2019

Current understanding of the origin of occipital headache falls short of distinguishing between cause and effect. Most preclinical studies involving trigeminovascular neurons sample neurons that are responsive to stimulation of dural areas in the anterior 2/3 of the cranium and the periorbital skin. Hypothesizing that occipital headache may involve activation of meningeal nociceptors that innervate the posterior ⅓ of the dura, we sought to map the origin and course of meningeal nociceptors that innervate the posterior dura overlying the cerebellum. Using AAV-GFP tracing and single-unit recording techniques in male rats, we found that neurons in C2–C3 DRGs innervate the dura of the posterior fossa; that nearly half originate in DRG neurons containing CGRP and TRPV1; that nerve bundles traverse suboccipital muscles before entering the cranium through bony canals and large foramens; that central neurons receiving nociceptive information from the posterior dura are located in C2–C4 spinal cord and that their cutaneous and muscle receptive fields are found around the ears, occipital skin and neck muscles; and that administration of inflammatory mediators to their dural receptive field, sensitize their responses to stimulation of the posterior dura, peri-occipital skin and neck muscles. These findings lend rationale for the common practice of attempting to alleviate migraine headaches by targeting the greater and lesser occipital nerves with anesthetics. The findings also raise the possibility that such procedures may be more beneficial for alleviating occipital than non-occipital headaches and that occipital migraines may be associated more closely with cerebellar abnormalities than in non-occipital migraines.SIGNIFICANCE STATEMENTOccipital headaches are common in both migraine and non-migraine headaches. Historically, two distinct scenarios have been proposed for such headaches; the first suggests that the headaches are caused by spasm or tension of scalp, shoulders, and neck muscles inserted in the occipital region, whereas the second suggests that these headaches are initiated by activation of meningeal nociceptors. The current study shows that the posterior dura overlying the cerebellum is innervated by cervicovascular neurons in C2 DRG whose axons reach the posterior dura through multiple intracranial and extracranial pathways, and sensitization of central cervicovascular neurons from the posterior dura can result in hyper-responsiveness to stimulation of neck muscles. The findings suggest that the origin of occipital and frontal migraine may differ.
Pregnancy in acromegaly is safe and is associated with improvements in IGF-1 concentrations
Authors: Hannon Anne Marie , O’Shea Triona , Thompson Claire A , Hannon Mark J , Dineen Rosemary , Khattak Aftab , Gibney James , O’Halloran Domhnall J , Hunter Steven , Thompson Christopher J , Sherlock Mark 
Published: January 2019

Pregnancy is rarely reported in acromegaly. Many patients are diagnosed in later life and younger patients may have subfertility due to hypopituitarism. We present a case series of 17 pregnancies in 12 women with acromegaly.
Twelve women with acromegaly who completed pregnancy were identified from centres involved in the Irish Pituitary Study. Eleven women had pituitary macroadenomas and one woman had a microadenoma. Only 5/17 pregnancies had optimal biochemical control of acromegaly preconception, as defined by IGF-1 concentration in the age-related reference level and plasma GH concentration of <2 μg/L. In 6/17 pregnancies, dopamine agonist treatment was continued during pregnancy; all other acromegaly treatments were discontinued during pregnancy.
Effect of pregnancy on acromegaly: No patient developed new visual field abnormalities, or symptoms suggestive of tumour expansion during pregnancy. In 9/12 patients, plasma IGF-1 concentrations that were elevated preconception normalised during pregnancy. There was a reduction in plasma IGF-1 concentrations, though not into the normal range, in a further two pregnancies.
Effect of acromegaly on pregnancy: 15 healthy babies were born at term; one patient underwent emergency C-section at 32 weeks for pre-eclampsia, and one twin pregnancy had an elective C-section at 35 weeks’ gestation. Blood pressure remained within normal limits in the remainder of the pregnancies. Gestational diabetes did not develop in any pregnancy.
Our data suggests that pregnancy in women with acromegaly is generally safe, from a maternal and foetal perspective. Furthermore, biochemical control tends to improve despite the withdrawal of somatostatin analogue therapy during pregnancy.
Új szempontok a sószenzitív hypertoniák patomechanizmusában
Authors: Sulyok Endre 
Published: January 2019

Abstract: This article shortly outlines the evolution of hypertonia from risk factors to end-organ damage. The pathogenetic role of salt intake is underlined and in the light of recent clinical and experimental observations, the importance of renal and extrarenal mechanism in the development of salt-sensitive hypertension is analysed. The generally accepted concept that the inefficient renal sodium excretion and the subsequent expansion of the extracellular space is the major factor in blood pressure elevation is challenged. Evidences have been provided that the retained sodium dissociates from the volume of extracellular space and, also from the blood pressure. It has been shown that the negatively charged macromolecules in the subcutaneous interstitium bind sodium ions in osmotically inactive form and store sodium reversibly. The local tissue hypertonicity induces monocytes/macrophages invasion and activation that causes increased expression of tonicity-responsive enhancer binding protein (TonEBP) and the secretion of vascular endothelial growth factor C that result in enhanced lymphangiogenesis. The expanded lymphatic system drains the excess sodium and volume back to the circulation. The reduction of buffer function of this system may contribute to the development or to worsening of hypertension. Similar buffer and barrier functions are attributed to the glycocalyx that covers the luminal surface of vascular endothelium. It is also recognised that the high sodium intake alone is an important pathogenetic factor in end-organ damage independent of hypertension. This may be accounted for by the induction and activation of Th17 cells as well as by the increased production of several pro-inflammatory and pro-fibrotic cytokines. Orv Hetil. 2019; 160(2): 43–49.
Assessment of nutrition status in transplant patients using imaging, serologic markers and functional testing: Which best predicts early reversal of malnutrition?
Authors: Atoa Sam , Mangus Richard S. 
Published: January 2019

Background and Hypothesis: Previous studies have shown that patients with malnutrition have worse clinical outcomes which lead to longer hospital stays and increased costs. Little has been studied in regards forms of testing such as functional 5M walk tests and serologic testing in predicting nutritional status.
Experimental Design or Project Methods: Adults with end-stage liver, kidney, or pancreatic failure and with pre-transplant computed tomography (CT) imaging were selected from the transplant database. Each group was separated by organ and compared to each other by each nutritional measurement. Measures of nutrition status included a scaled scoring of core muscle mass, and visceral and subcutaneous fat stores, protein and albumin serum levels, BMI and sarcopenic index.
Results: It is clear that Liver patients started off much more malnourished than other organ groups as indicated by the low protein and albumin levels at day 0. Liver patients with severe sarcopenia continued to lose weight after 90 days despite increased albumin levels which suggests there is a rapid and significant loss of weight post-transplant due to diuresis which doesn’t reverse until around day 60.
Conclusion and Potential Impact: Serologic testing and imaging seemed to be good indicators of early reversal of malnutrition while functional testing did not. These finding will be analyzed against a control group to see which best predicts clinical outcomes such as length of post-operative hospital stays and fall risks. Being able to predict outcomes through nutritional status will help us to better prescreen high risk transplant candidates.
The Examination of non-pharmacologic treatment of pain after spinal cord injury
Authors: Piatt J. A. , Eldridge L. , Baker J. M. 
Published: January 2019

Background: One of the primary debilitating secondary health conditions experienced by individuals living with a spinal cord injury (SCI) is chronic pain. Approximately, over 30% of SCI patients endure chronic pain after sustaining the injury, and engage in opioid pharmacotherapy as the first form of treatment. The increase in use and misuse of prescribed opioids for chronic pain can lead to both physical and psychological health risks. This danger is exacerbated by the notion that a large percentage of the SCI population have a pre-existing condition of drug and alcohol abuse and addiction. This study will examine how pain is actually being addressed through non-pharmaceutical methods among the SCI adult population.
Experimental Design: Employing a cross-sectional web survey design with a convenience sample of adults with a SCI. A Qualtrics survey is currently being administered to known individuals with SCIs via email. The survey questions will illuminate what pain management strategies are being implemented in the SCI population within the US.
Anticipated Results: The results from the data will provide insight on what non-pharmacological interventions can be employed in place of or in combination with the pharmacological management. This will allow community-based rehabilitation therapies to incorporate appropriate pain management strategies.
Potential Impact: Non-pharmacological interventions may hold the answer in treating chronic pain in the SCI population by limiting or eliminating the use of opioids. This study will help develop the most appropriate non-pharmacological intervention to test in quasi-experimental clinical trials, and ultimately minimize the use of opioids for chronic pain.