bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic evaluation of guideline implementation in primary care: a systematic review
Authors: Kovacs Eva , Wang Xiaoting , Strobl Ralf , Grill Eva 
Published: July 2019

Abstract

Purpose
To review the economic evaluation of the guideline implementation in primary care.

Data sources
Medline and Embase.

Study selection
Electronic search was conducted on April 1, 2019, focusing on studies published in the previous ten years in developed countries about guidelines of non-communicable diseases of adult (≥18 years) population, the interventions targeting the primary care provider. Data extraction was performed by two independent researchers using a Microsoft Access based form.

Results of data synthesis
Among the 1338 studies assessed by title or abstract, 212 qualified for full text reading. From the final 39 clinically eligible studies, 14 reported economic evaluation. Cost consequences analysis, presented in four studies, provided limited information. Cost-benefit analysis was reported in five studies. Patient mediated intervention, and outreach visit applied in two studies showed no saving. Audit resulted significant savings in lipid lowering medication. Audit plus financial intervention was estimated to reduce referrals into secondary care. Analysis of incremental cost-effectiveness ratios was applied in four studies. Educational meeting evaluated in a simulated practice was cost-effective. Educational meeting extended with motivational interview showed no improvement; likewise two studies of multifaceted intervention. Cost-utility analysis of educational meeting supported with other educational materials showed unfavourable outcome.

Conclusion
Only a minor proportion of studies reporting clinical effectiveness of guideline implementation interventions included any type of economic evaluation. Rigorous and standardized cost-effectiveness analysis would be required, supporting decision-making between simple and multifaceted interventions through comparability.
Implications of a Dating Analysis of Hippoboscoidea (Diptera) for the Origins of Phoresis in Feather Lice (Psocodea: Phthiraptera: Philopteridae)
Authors: de Moya Robert S 
Published: July 2019

Abstract
Hippoboscidae (Samouelle 1819) is a family of blood feeding Diptera, which can be phoretic vectors for parasitic feather lice (Philopteridae Burmeister 1838). Hippoboscid flies are understood to provide opportunities for increased instances of dispersal and host-switching for feather lice. This intimate relationship between hippoboscid fly and feather louse may have hypothetically existed since the origin of avian-specialized Hippoboscidae. Thus, phoretic dispersal may have affected patterns of diversification in feather lice over millions of years. To test this, a dating analysis of a previously published Hippoboscoidea data set was performed using known fossil calibrations. The results of the dating analysis suggest Hippoboscoidea diversified shortly after the K-Pg boundary, similar to their modern vertebrate hosts. A maximum age of the avian feeding Ornithomyini is estimated to have occurred around the origin of parasitic feather lice. This maximum divergence date suggest this phoretic relationship could have existed for much of the diversification of avian feather lice and had the potential to influence patterns of diversification due to dispersal and host-switching among avian hosts.
Implications of early-life indicators for survival rate, subsequent growth performance, and carcass characteristics of commercial pigs1
Authors: Zeng Zhikai K , Urriola Pedro E , Dunkelberger Jenelle R , Eggert John M , Vogelzang Roos , Shurson Gerald C , Johnston Lee J 
Published: July 2019

Abstract
As a result of genetic selection for increased litter size, modern, highly prolific sows often produce large litters with an increased percentage of light birth weight (BiW) piglets compared with less prolific females. However, there is limited information elucidating what proportion of light BiW piglets that express compensatory growth and how these pigs might be identified at a young age. The objective of this study was to analyze the effect of birth weight and early phase growth on preweaning mortality, subsequent growth performance, and carcass characteristics of pigs. Individual records collected on 7,654 commercial crossbred pigs were used for analyses. A segmented regression model was used to analyze the effect of birth weight on preweaning survival and a series of mixed models were used to analyze the effect of birth weight (n = 7,654) group on weights recorded at: weaning (n = 6,777), nursery exit (n = 4,805), and finishing exit (n = 1,417); hot carcass weight (HCW), and lean percentage (n = 4,572). The effect of growth rate group was defined during suckling (< 225 or ≥ 225 g/d) or the nursery phase (< 424 or ≥ 424 g/d). Preweaning mortality, growth rate, BW, and carcass traits were adjusted to a standard age, and ADG and lean percentage were calculated. Results of segmented regression analysis showed that the slope of preweaning mortality on birth weights below 0.99 kg differed (P < 0.05) from the slope of preweaning mortality regressed on birth weights above 0.99 kg. The mixed model analyses showed a positive linear effect (P < 0.05) of BiW and quadratic effect (P < 0.05) of sow parity on age-adjusted finishing weight (FiW), HCW, and lean percentage. The positive influences of increasing BiW were greater (P < 0.05) in age-adjusted FiW and HCW for pigs with slow suckling growth rate compared with those with fast suckling growth rate. Pigs with fast nursery growth rate had greater (P < 0.05) age-adjusted FiW and HCW compared with the slow growing nursery contemporaries. In conclusion, piglets born weighing less than 1 kg were at a higher risk of preweaning mortality than piglets born weighing 1 kg or greater. Light BiW pigs, but not heavy BiW pigs, may lose compensatory growth capability if growth rate during the suckling phase is below the average level.
Transmission of Citrus leprosis virus C by the Mite, Brevipalpus yothersi (Acari: Tenuipalpidae), on Four Species of Citrus
Authors: Rodríguez-Ramírez Renata , Santillán-Galicia Ma Teresa , Guzmán-Franco Ariel W , Ortega-Arenas Laura Delia , Teliz-Ortiz Daniel , Sánchez-Soto Saul , Robles-García Pedro L 
Published: July 2019

Abstract
Transmission of the virus, Citrus leprosis virus C (CiLV-C) (Cilevirus) by Brevipalpus yothersi Baker, on different citrus species was evaluated under greenhouse conditions. First, the relationship between acquisition access periods (AAPs; 1, 12, 24, 36, and 48 h) and virus concentration in mites was determined. Second, the ability of B. yothersi to transmit CiLV-C to orange, mandarin, grapefruit, and lime trees was measured. We then assessed the establishment of mites on the different citrus species as measured by their population increase on each species. We found no relationship between AAPs and virus load in mites. The virus was found in all mites tested but there was no difference in virus quantities among the treatments. We selected an AAP of 24 h for the transmission experiment. Brevipalpus yothersi transmitted the virus to all citrus species evaluated, but susceptibility was different. The number of infected leaves was greater on orange and mandarin compared with grapefruit and lime. Furthermore, populations of B. yothersi successfully established on orange and mandarin, but not on grapefruit and lime trees. The implications of our results in the virus–mite–citrus plant relationship are discussed.
Student and Instructor Generated Open Educational Resources Compare Favorably to a Traditional Textbook
Authors: Stovall Jeremy P , Laird Shelby G , Welford Lana , Williams Allison 
Published: July 2019

AbstractOpen Educational Resources (OER) are freely available materials that can be used in courses and modified by instructors. We developed an online OER silviculture textbook (OT). Some sections of OT were developed by the instructor, whereas others were developed by students enrolled in a silviculture course and subsequently edited by the instructor. As a preliminary examination of the effectiveness and student preference of OT, we administered a knowledge assessment and survey to both freshman and junior-level forestry students. We compared OT to a highly respected textbook in the field, The Practice of Silviculture, 9th Edition (Smith et al. 1997). Based on this study, both resources performed similarly and were similarly preferred by students. Although there are a number of limitations to this preliminary study (small sample size, only conducted at a single university, formatting both sources as paper copies) and to OER (time-consuming to create, lack of funding, lack of peer review), our results support further exploration of OER for use in forestry courses.
Impacts of nitrogen deposition on terrestrial plant diversity: a meta-analysis in China
Authors: Han Wen-Juan , Cao Jia-Yu , Liu Jin-Liang , Jiang Jia , Ni Jian 
Published: July 2019

AbstractAimsWith the global atmospheric nitrogen (N) deposition increasing, the effect of N deposition on terrestrial plant diversity has been widely studied. Some studies have reviewed the effects of N deposition on plant species diversity; however, all studies addressed the effects of N deposition on plant community focused on species richness in specific ecosystem. There is a need for a systematic meta-analysis covering multiple dimensions of plant diversity in multiple climate zones and ecosystems types. Our goal was to quantify changes in species richness, evenness and uncertainty in plant communities in response to N addition across different environmental and experimental contexts.MethodsWe performed a meta-analysis of 623 experimental records published in English and Chinese journals to evaluate the response of terrestrial plant diversity to the experimental N addition in China. Three metrics were used to quantify the change in plant diversity: species richness (SR), evenness (Pielou index) uncertainty (Shannon index).Important FindingsResults showed that (i) N addition negatively affected SR in temperate, Plateau zones and subtropical zone, but had no significant effect on Shannon index in subtropical zones; (ii) N addition decreased SR, Shannon index and Pielou index in grassland, and the negative effect of N addition on SR was stronger in forest than in grassland; (iii) N addition negatively affected plant diversity (SR, Shannon index and Pielou index) in the long term, whereas it did not affect plant diversity in the short term. Furthermore, the increase in N addition levels strengthened the negative effect of N deposition on plant diversity with long experiment duration; and (iv) the negative effect of ammonium nitrate (NH4NO3) addition on SR was stronger than that of urea (CO(NH2)2) addition, but the negative effect of NH4NO3 addition on Pielou index was weaker than that of CO(NH2)2 addition. Our results indicated that the effects of N addition on plant diversity varied depending on climate zones, ecosystem types, N addition levels, N type and experiment duration. This underlines the importance of integrating multiple dimensions of plant diversity and multiple factors into assessments of plant diversity to global environmental change.
Ultra-diffuse galaxies without dark matter
Authors: Silk Joseph 
Published: July 2019

ABSTRACT
I develop a high-velocity galaxy collision model to explain a rare but puzzling phenomenon, namely the apparent existence of ultra-diffuse galaxies with little dark matter. Predictions include simultaneous triggering of overpressured dense clouds to form luminous old globular clusters, a protogroup environment to generate high relative velocities of the initially gas-rich galaxies in the early universe, and spatially separated dark haloes, possibly detectable via gravitational lensing and containing relic low-metallicity stars with enhanced α/Fe at ultra-low surface brightness.
Minimal-Access Endoscopic Endonasal Management of Dysthyroid Optic Neuropathy: The Dysthone Study
Authors: Zah-Bi Gilles , Abeillon-du Payrat Juliette , Vie Anne Laure , Bournaud-Salinas Claire , Jouanneau Emmanuel , Berhouma Moncef 
Published: July 2019

Abstract

BACKGROUND
Dysthyroid optic neuropathy (DON) is a devastating complication of thyroid eye disease. Corticosteroids are the primary medical treatment for DON, but some refractory patients may require surgical management.

OBJECTIVE
To evaluate the efficacy of endoscopic endonasal decompression of the orbital apex in refractory DON.

METHODS
This study included patients with refractory DON who underwent endoscopic endonasal decompression of the orbital apex from February 2015 to October 2016. A total of 23 orbital apices were decompressed across 17 patients. Visual acuity, ophthalmometry, tonometry, and visual field were evaluated at the preoperative, early and delayed postoperative stages. Statistical analyses were performed using RStudio software. A Wilcoxon test for matched data was performed to determine if there was a statistically significant difference between pre- and postsurgical treatment for the following items: visual acuity, proptosis, visual field, and intraocular pressure.

RESULTS
Visual acuity improved in 69.5% of the cases with a mean gain of 2.5 points ± 1.6 (P < .05). Additionally, there was an 18.3% reduction in mean proptosis across all cases (P < .05) and a 13.7% decrease in intraocular pressure (P < .05) for all patients. Finally, visual field improved in 82.6% (P < .05) of the cases. The mean time for follow-up was of 6.28 ± 3.7 mo. There were 3 cases of transient postoperative rhinitis and 2 cases of transient diplopia. Two patients experienced recurrence at 4 and 8 mo, respectively.

CONCLUSION
Endoscopic endonasal decompression of the orbital apex significantly improves visual parameters. As a result, multidisciplinary screening for patients is crucial to ensure prompt surgical decompression.
Tungiasis: a highly neglected disease among neglected diseases. Case series from Nduta refugee camp (Tanzania)
Authors: Nájera Villagrana Sandra Montserrat , García Naranjo Santisteban Alejandra 
Published: July 2019

Abstract
Tungiasis is a highly prevalent yet neglected disease of populations affected by extreme poverty. It causes great discomfort and pain, leads to social stigmatization and, when left untreated, can cause serious complications. Although natural repellents have been shown to be effective, too little is being done in terms of systematic prevention and treatment. In addition, self-treatment (usually extraction of fleas with non-sterile sharp instruments) comports high risks of infection, notably with viral hepatitis and human immunodeficiency virus. In this article, we report seven severe cases of tungiasis in children living in a refugee camp in Tanzania, all of whom were treated with surgical extraction of the fleas because the topical treatment (dimethicone) was not available. Refugee camps—particularly in sub-Saharan Africa where tungiasis is endemic—should be considered high-risk areas for the condition. Aid organizations should engage in active case searching, and health promotion should be systematically carried out.
Overcoming Parochialism in American Public Administration
Authors: Beagles Jonathan E , Schnell Sabina , Gerard Catherine 
Published: July 2019

AbstractFor decades, there have been complaints about the parochialism of American public administration. Too often, scholars and practitioners assume the American experience is exceptional. It is time to change this mindset. There is much to be learned from the experience of other countries, and some major problems unavoidably span national borders. There are three ways to overcome parochialism: by raising our sights to the macro-level of analysis, by engaging more broadly with other regions and fields of inquiry, and by institutionalizing diversity in our research methods, conferences, journals, and curriculum.
Female genital cutting in the Gambia: can education of women bring change?
Authors: Mboge Baturu , Knapp Kenneth , Tantsyura Vadim , Jagne Siga Fatima , Alamgir Hasanat 
Published: July 2019

Abstract

Background
In the Gambia, three out of four women of reproductive age have undergone Female Genital Cutting (FGC). Many studies and policy advocates suggest that for such a practice that is deeply rooted in culture, a more holistic approach focusing on educating the population will have sustainable impact. This research examined whether educational level of women has an association with their attitude towards the practice of FGC.

Methods
Data from the 2013 Gambia Demographic Health Survey (GDHS) were analyzed. The sample included 6217 households: 10,233 females aged between 15 to 49 years and 3831 males between 15–59 years. This study focused only on women participants. The outcome variable was the attitude of women toward the practice of FGC.

Results
In multivariate regression model, women who were circumcised are found to have 80 times higher odds of supporting FGC [Odds Ratio = 80 (95% CI 50.93–124.4)] compared to uncircumcised women. Women with primary and secondary level education have lower odds of supporting FGC [OR = 0.73 (95% CI 0.915–0.007)) and those with higher education had the lowest odds [OR = 0.28 (95% CI 0.147–0.543)) of supporting FGC relative to women with no education at all.

Conclusions
Education and awareness programs targeting women who are married and older, those with less education and those who are already circumcised can help change attitudes towards the practice of FGC.
The therapeutic efficacy of intravenous immunoglobulin in anti-neutrophilic cytoplasmic antibody-associated vasculitis: a meta-analysis
Authors: Shimizu Takashi , Morita Takayoshi , Kumanogoh Atsushi 
Published: July 2019

Abstract

Objectives
The therapeutic effects of IVIG in patients with ANCA-associated vasculitis (AAV) have not been established so far. This study aims to estimate the effects of IVIG on AAV by conducting a systematic review and meta-analysis.

Methods
A comprehensive systematic review was conducted in accordance with the guidelines of PRISMA (Preferred Reporting Items for Systematic Reviews And Meta-analyses). PubMed and Google Scholar were used to search for original studies on AAV and collect clinical data before and after IVIG treatment. A meta-analysis of each clinical parameter was performed, and standardized mean difference (SMD) and 95% CI were calculated using the random effects model.

Results
A total of 220 studies were identified, and nine met the selection criteria for the meta-analysis. IVIG was administered to active AAV patients as an immunomodulatory therapy in the nine studies selected. Significant reductions in BVAS (SMD –1.7; 95% CI [–2.66, –0.73]; P = 0.0006), ANCA (SMD –0.72; 95% CI [–1.13, –0.31]; P = 0.0006) and CRP (SMD –0.92; 95% CI [–1.49, –0.35]; P = 0.002) were noted within 6 months after administration of IVIG. Subgroup analysis in the unmodified immunotherapy population showed reductions in BVAS (SMD –1.39; 95% CI [–2.31, –0.48]; P = 0.003) and CRP (SMD –0.56; 95% CI [–0.93, –0.19]; P = 0.002) within half a month after IVIG treatment.

Conclusion
IVIG was associated with rapid improvements in disease activity and the related biomarkers in patients with active AAV.
Mental Health among Older Adults with Caregiving Needs: The Role of Social Networks
Authors: Tang Fengyan , Jang Heejung , Mulvaney Elizabeth A , Lee Jane Seoyoon , Musa Donald , Beach Scott 
Published: July 2019

Abstract
A major challenge facing an aging society is the increased caregiving needs among community-dwelling older adults with chronic conditions. Reliance on social relations may help address caregiving needs and maintain older adults’ mental well-being. This study examines the roles of different aspects of social relations—social network size, social support, and service use—in the association between caregiving needs and mental health status (MHS). Using a sample of adults age 55 and over in an urban setting, authors tested the direct, mediation, and moderation effects models of social relations. Structural equation modeling was applied and latent variables of caregiving needs, MHS, and social network size were identified. Results showed that caregiving needs and informal social support (that is, network size, positive support, and negative strain) were directly related to MHS and that informal social support partially mediated the negative effect of caregiving needs on MHS; by contrast, service use moderated the association, indicating that those with caregiving needs who used more services were in better MHS than their counterparts with less service use. Findings point to the importance of social work interventions aimed at improving social relations and enhancing awareness and access to social services.
The extent and uptake of mathematics support in higher education: results from the 2018 survey
Authors: Grove Michael , Croft Tony , Lawson Duncan 
Published: July 2019

Abstract
In response to the well-documented challenges associated with the ‘mathematics problem’ in UK higher education, many institutions have implemented a programme of mathematics support. Previous surveys within the UK, undertaken in 2001, 2004 and, most recently, 2012, have shown growth in the number of institutions offering such support and indicate that the dominant form of provision is through a drop-in model. Here we report on a 2018 survey of higher education providers in England and Wales undertaken to establish not only the extent of current provision but also understand the scale of its delivery. We find that overall the proportion of higher education institutions offering mathematics support remains broadly the same, but there is considerable variation in how this support is delivered within institutions. While the drop-in model remains most common, we see evidence that the methods used to provide mathematics support are expanding and that the range of levels and subjects studied of targeted student cohorts is widening. For the first time we are able to report on the volume of use of mathematics support by students across England and Wales, and although dependent upon the institutional context, we see clear evidence of the extensive use being made of it by learners.