bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wheat stocks and the cointegration of wheat prices
Authors: Slade Peter , Gray Richard 
Published: July 2018

AbstractWe examine the effect of wheat stocks on the relationship between port and inland wheat prices in western Canada after the dissolution of the Canadian Wheat Board in 2012. Standard statistical tests find no evidence that the port price is cointegrated with inland prices. We argue that large harvests in 2013–2014 and 2014–2015 are responsible for this lack of cointegration. A simple theoretical model demonstrates how wheat stocks drive a wedge between inland and port prices. After including wheat stocks in the cointegrating vector, we find the expected cointegrating relationships between the port and inland prices. Using an error correction model, we show that a 10% increase in the wheat stocks reduces producer prices in Alberta and Manitoba by 6% and 4%, respectively. We conclude by discussing policy options for reducing the size of wheat stocks on the prairies.
Chronic opioid use and clinical outcomes in lung transplant recipients: A single‐center cohort study
Authors: Drees David , Tumin Dmitry , Miller Rebecca , Kirkby Stephen , Bhalla Tarun , Tobias Joseph D. , Hayes Don 
Published: July 2018

AbstractIntroductionChronic opioid use is common after organ transplantation, and has been associated with poor outcomes in transplantation of abdominal organs. However, little is known about possible influences of chronic opioid use on outcomes of lung transplantation (LTx).ObjectivesWe assessed whether long‐term chronic opioid use influenced clinical outcomes among LTx recipients at our program.MethodsWe retrospectively evaluated chronic opioid use among bilateral LTx recipients ages 12 and older followed at our institution 1‐5 years post‐transplant. Chronic opioid use was defined as ≥3 months of consecutive prescribed use. Outcomes included survival, hospitalization, emergency department and urgent care visits, forced expiratory volume in one second (FEV1), and allograft rejection.ResultsTwenty‐one patients ages 15‐50 years met inclusion criteria. On multivariable analysis, initiation of chronic opioid use was followed by increased mortality hazard (hazard ratio=7.1; 95% confidence interval [CI]: 1.1, 45.0, P = 0.037) and decreased FEV1 (‐16%; 95% CI: ‐24%, ‐7%; P < 0.001), although no differences were observed in risk of acute care visits, inpatient admission, or chronic rejection.ConclusionThis analysis presents the first evidence that late‐onset chronic opioid use may be associated with decreased lung function and increased mortality after LTx. Therefore, evaluation of chronic opioid use should be included in the routine monitoring of transplant recipients, to better define the impact of this risk factor on LTx outcomes.
The association between the incidence of intestinal graft‐vs‐host disease and antibiotic use after allogeneic hematopoietic stem cell transplantation
Authors: Hidaka Daisuke , Hayase Eiko , Shiratori Souichi , Hasegawa Yuta , Ishio Takashi , Tateno Takahiro , Okada Kohei , Goto Hideki , Sugita Junichi , Onozawa Masahiro , Nakagawa Masao , Kahata Kaoru , Endo Tomoyuki , Hashimoto Daigo , Teshima Takanori 
Published: July 2018

AbstractIntestinal microbiota plays an important role in the regulation of allogeneic immune reaction after allogeneic hematopoietic stem cell transplantation (allo‐SCT). Intestinal graft‐vs‐host disease (GVHD) is one of the major causes of mortality after allo‐SCT and often complicated with intestinal dysbiosis. Recent studies suggest that antibiotic‐induced dysbiosis is a risk factor for intestinal GVHD. We retrospectively evaluated the impacts of antibiotic use on the incidence of intestinal GVHD occurring before day 100 after allo‐SCT. Among 213 patients who underwent allo‐SCT, 200 patients achieving engraftment were analyzed. Antibiotics were classified into carbapenem, quinolone, penicillin, cephem, and glycopeptide. Among 128 patients who developed acute GVHD, intestinal GVHD developed in 36 patients. Patients with intestinal GVHD received significantly longer administration of carbapenem and glycopeptide compared to those without it in periengraftment period. In multivariate analysis, use of carbapenem for greater than 7 days was associated with an increased risk of intestinal GVHD. However, use of antibiotics for greater than 7 days was not associated with poor overall survival and high nonrelapse mortality. Long use of carbapenem in periengraftment period may be a risk for intestinal GVHD. Prospective studies are required to validate our findings.
Liraglutide relieves cardiac dilated function than DPP‐4 inhibitors
Authors: Hiramatsu Takeyuki , Asano Yuko , Mabuchi Masatsuna , Imai Kentaro , Iguchi Daiki , Furuta Shinji 
Published: July 2018

AbstractIntroductionDiabetes mellitus is a progressive disease with cardiovascular complications. This study evaluated the effects of liraglutide, a glucagon‐like peptide‐1 analogue and the dipeptidyl peptidase 4 inhibitors sitagliptin and linagliptin on cardiac function in type 2 diabetes patients with renal impairment.Materials and MethodsA total of 139 patients who were referred because of suboptimal glycaemic control were randomly assigned to liraglutide 0.9 mg/d (n = 45), sitagliptin 50 mg/d, (n = 49) or linagliptin 5 mg/d (n = 45) at enrolment and were evaluated. Blood glucose, glycosylated haemoglobin and serum creatinine were assayed every 3 months for 48 months. Echocardiography was performed every 12 months for 48 months.ResultsCompared with baseline, fasting glucose, postprandial glucose, and systolic and diastolic pressure, but not estimated glomerular filtration rate, significantly decreased in all three groups. Albuminuria decreased from 24 to 48 months with liraglutide, but only from 24 to 30 months with sitagliptin and linagliptin. Diastolic function, assessed by E/e′ or left atrial dimension improved only with liraglutide.ConclusionsLiraglutide was effective for glucose and blood pressure control, reduced albuminuria and improved diastolic function. Diastolic function was not improved by sitagliptin and linagliptin.
Encapsulation of young donor age dopaminergic grafts in a GDNF‐loaded collagen hydrogel further increases their survival, reinnervation, and functional efficacy after intrastriatal transplantation in hemi‐Parkinsonian rats
Authors: Moriarty Niamh , Cabré Sílvia , Alamilla Verónica , Pandit Abhay , Dowd Eilís 
Published: July 2018

AbstractBiomaterials have been shown to significantly improve the outcome of cellular reparative approaches for Parkinson's disease in experimental studies because of their ability to provide transplanted cells with a supportive microenvironment and shielding from the host immune system. However, given that the margin for improvement in such reparative therapies is considerable, further studies are required to fully investigate and harness the potential of biomaterials in this context. Given that several recent studies have demonstrated improved brain repair in Parkinsonian models when using dopaminergic grafts derived from younger foetal donors, we hypothesized that encapsulating these cells in a supportive biomaterial would further improve their reparative efficacy. Thus, this study aimed to determine the impact of a GDNF‐loaded collagen hydrogel on the survival, reinnervation, and functional efficacy of dopaminergic neurons derived from young donors. To do so, hemi‐Parkinsonian (6‐hydroxydopamine‐lesioned) rats received intrastriatal transplants of embryonic day 12 cells extracted from the rat ventral mesencephalon either alone, in a collagen hydrogel, with GDNF, or in a GDNF‐loaded collagen hydrogel. Methamphetamine‐induced rotational behaviour was assessed at three weekly intervals for a total of 12 weeks, after which rats were sacrificed for postmortem assessment of graft survival. We found that, following intrastriatal transplantation to the lesioned striatum, the GDNF‐loaded collagen hydrogel significantly increased the survival (4‐fold), reinnervation (5.4‐fold), and functional efficacy of the embryonic day 12 dopaminergic neurons. In conclusion, this study further demonstrates the significant potential of biomaterial hydrogel scaffolds for cellular brain repair approaches in neurodegenerative diseases such as Parkinson's disease.
Synthesis of high surface area mesoporous silica SBA‐15 for hydrogen storage application
Authors: Bera Biswajit , Das Nandini 
Published: July 2018

AbstractIn the present report, mesoporous silica SBA‐15 was synthesized by different methods such as room temperature aging, hydrothermal, and sonication‐mediated hydrothermal methods. The effect of different time and temperature on the synthesis method was investigated by conventional characterization techniques. The powders synthesized by different methods showed different properties, mainly in morphology and pore volume. In comparison to others, the powder synthesized by the hydrothermal method at 100°C for 48 hours showed exceptionally high surface area of 3274 m2/g. To date, as per our knowledge, no such value was reported in literature. Finally, the powders were characterized by H2 storage capacity by the adsorption‐desorption method using 99.999% H2. The hydrogen adsorption capacity of the same powder was observed at 6.02 wt%. Also, this value seems to be the highest H2 adsorption capacity in comparison to other powders described in literature.
Food literacy competencies: A conceptual framework for youth transitioning to adulthood
Authors: Slater Joyce , Falkenberg Thomas , Rutherford Jessica , Colatruglio Sarah 
Published: July 2018

AbstractObjective: The modern foodscape has changed dramatically in recent decades in terms of where, what, how and with whom we eat. This has been facilitated by a transition from traditional, healthy and basic foods prepared in the home to ultraprocessed, unhealthy foods requiring little planning and preparation prior to consuming. Consequently, many youth lack the food literacy (knowledge, skills and critical perspectives) necessary to be well and minimize their risk of obesity and chronic diseases, in the context of a complex food system. The specific dimensions of these knowledge, skills and dispositions, however, are unknown. This study identified critical food literacy competencies required by youth as they transition to independent adulthood.Design: This study employed a Delphi methodology to achieve consensus statements on critical food literacy competencies within a framework encompassing cognitive, psychomotor and affective dimensions.Participants: A panel of 41 experts including dietitians, teachers and college/university students participated in in‐depth interviews.Analysis: Results were thematically analysed and incorporated into two subsequent surveys completed by panel members. Rater agreement was set at 75% agreeing/strongly agreeing with survey items. A panel subgroup further delineated results into competency statements.Results: Within the themes of “confidence and empowerment,” “joy and meaning” and “sustainable and equitable food systems,” 16 broad competency areas, and 59 specific competencies were identified. These were assembled into a Food Literacy Framework.Conclusion: Results can be used to support food and nutrition education in community settings as well as the formal school system, and to advocate for resources to support food literacy education programmes.
Colour variability of beef in young bulls from fifteen European breeds
Authors: Ripoll Guillermo , Albertí Pere , Panea Begoña , Failla Sebastiana , Hocquette Jean F. , Dunner Susana , Sañudo Carlos , Olleta José L. , Christensen Mette , Ertbjerg Per , Richardson Ian , Concetti Serafino , Williams John L. 
Published: July 2018

SummaryThe objective of this study was to determine the variation of the colour of longissimus thoracis muscle within and among fifteen European cattle breeds reared under comparable management conditions. A total of 436 unrelated purebred young bulls from fifteen European breeds (Aberdeen Angus, Highland, Jersey, South Devon, Danish Red, Holstein, Simmental, Asturiana de las Montañas (also known as Casina), Asturiana de los Valles, Avileña‐Negra Ibérica, Pirenaica, Marchigiana, Piemontese, Charolais and Limousin) were reared in five experimental research centres in the United Kingdom, Denmark, Spain, Italy and France. The pH of M. longissimus thoracis was measured at 24 h and after 10 days of ageing and colour at 48 h and 10 days. Two generalised linear models, Pearson correlations and a hierarchical cluster analyses were carried out. Lean meat colour differed significantly between breeds, and these fifteen European breeds could be grouped according to four classes of commercial interest: ‘very bright and pale‐red’, ‘bright and pale’, ‘red’ and ‘dark and dull red’. These groups were partially related to body size and carcass traits, fatness and muscle development and structure, and were controlled by differences in gene expression within each breed.
Corrosion resistance of Al2O3‐Y2O3‐SiC coating on depleted uranium prepared by cathode plasma electrolytic deposition
Authors: Deng Shunjie , Jiang Chi , Liu Tianwei , Hu Yin , Ding Jingjing , Shuai Maobing 
Published: July 2018

AbstractAl2O3‐Y2O3‐SiC composite coatings were prepared on depleted uranium by cathode plasma electrolytic deposition in Al(NO3)3, Y(NO3)3, SiC nanoparticles and anhydrous ethyl alcohol mixture. The resulting coating consisted of an inner barrier layer and an outer porous layer. The SiC nanoparticles were incorporated into the composite coating and decreased the coating porosity by filling the pores. The potentiodynamic polarization test and neutral salt spray test revealed that the corrosion resistance of depleted uranium was enhanced by the composite coating. Moreover, with increasing the content of SiC nanoparticles in the coating, the coating corrosion resistance was improved gradually.
Phenotypic plasticity at the edge: Contrasting population‐level responses at the overlap of the leading and rear edges of the geographical distribution of two Scurria limpets
Authors: Broitman Bernardo R. , Aguilera Moisés A. , Lagos Nelson A. , Lardies Marco A. 
Published: July 2018

AbstractAimTo examine the role of ocean temperature and chemistry as drivers of interpopulation differences in multiple phenotypic traits between rear and leading edge populations of two species of limpet.LocationThe coast of north‐central Chile, western South America.TaxonMollusca, Gastropoda (Lottidae).MethodsWe used field and laboratory experiments to study the ecology and physiology of individuals from populations located at the overlap of the rear and leading edges of their respective geographical distributions. At the same time, we characterized local environmental regimes, measuring seawater physical and chemical properties.ResultsTowards the edge of their range, individuals from the leading edge species gradually reduced their shell length, metabolic rate and thermal response capacity, and increased carbonate content in their shells. Individuals of the rear edge species showed dissimilar responses between sites. Contrasting behavioural responses to experimental heating reconciled observations of an unintuitive higher maximal critical temperature and a smaller thermal safety margin for individuals of the rear edge populations. Physical–chemical characterization of seawater properties at the site located on the core of the upwelling centre showed extreme environmental conditions, with low oxygen concentration, high pCO2 and the episodic presence of corrosive seawater. These challenging environmental conditions were reflected in reduced growth for both species.Main conclusionsWe found different spatial patterns of phenotypic plasticity in two sister species around the leading and trailing edges of their distributions. Our results provide evidence that environmental conditions around large upwelling centres can maintain biogeographical breaks through metabolic constraints on the performance of calcifying organisms. Thus, local changes in seawater chemistry associated with coastal upwelling circulation emerge as a previously overlooked driver of marine range edges.
Ablation of Ggnbp2 impairs meiotic DNA double‐strand break repair during spermatogenesis in mice
Authors: Guo Kaimin , He Yan , Liu Lingyun , Liang Zuowen , Li Xian , Cai Lu , Lan Zi‐Jian , Zhou Junmei , Wang Hongliang , Lei Zhenmin 
Published: July 2018

AbstractGametogenetin (GGN) binding protein 2 (GGNBP2) is a zinc finger protein expressed abundantly in spermatocytes and spermatids. We previously discovered that Ggnbp2 resection caused metamorphotic defects during spermatid differentiation and resulted in an absence of mature spermatozoa in mice. However, whether GGNBP2 affects meiotic progression of spermatocytes remains to be established. In this study, flow cytometric analyses showed a decrease in haploid, while an increase in tetraploid spermatogenic cells in both 30‐ and 60‐day‐old Ggnbp2 knockout testes. In spread spermatocyte nuclei, Ggnbp2 loss increased DNA double‐strand breaks (DSB), compromised DSB repair and reduced crossovers. Further investigations demonstrated that GGNBP2 co‐immunoprecipitated with a testis‐enriched protein GGN1. Immunofluorescent staining revealed that both GGNBP2 and GGN1 had the same subcellular localizations in spermatocyte, spermatid and spermatozoa. Ggnbp2 loss suppressed Ggn expression and nuclear accumulation. Furthermore, deletion of either Ggnbp2 or Ggn in GC‐2spd cells inhibited their differentiation into haploid cells in vitro. Overexpression of Ggnbp2 in Ggnbp2 null but not in Ggn null GC‐2spd cells partially rescued the defect coinciding with a restoration of Ggn expression. Together, these data suggest that GGNBP2, likely mediated by its interaction with GGN1, plays a role in DSB repair during meiotic progression of spermatocytes.
Evidence for sex difference in the CSF/plasma albumin ratio in ~20 000 patients and 335 healthy volunteers
Authors: Parrado‐Fernández Cristina , Blennow Kaj , Hansson Magnus , Leoni Valerio , Cedazo‐Minguez Angel , Björkhem Ingemar 
Published: July 2018

AbstractGiven sex‐related differences in brain disorders, it is of interest to study if there is a sex difference in the permeability of the blood‐cerebrospinal fluid barrier (BCSFB) and the blood‐brain barrier (BBB). The CSF/serum albumin ratio (QAlb) is a standardized biomarker that evaluates the function of these barriers. In previous studies, contradictory results have been reported with respect to sex difference using this quotient, possibly because of small population sizes and heterogeneity with respect to ages. QAlb measurements in more than 20 000 patients between 1 and 90 years visiting our hospitals revealed a significant sex difference in all age groups also when excluding patients with pathologically high CSF albumin > 400 mg/L. Similar pattern was found in 335 healthy volunteers in similar age intervals. Although also other factors are likely important, our observation is consistent with lower integrity of the brain barriers in males. If the difference in QAlb is caused mainly by a difference in barrier function, this may require different drug doses and strategies for efficient central nervous system (CNS) delivery in males and females, as well as it may indicate differences in brain metabolism. Moreover, our study emphasizes that different reference values should be used both for different ages and sexes.
A positive feedback loop between miR‐181b and STAT3 that affects Warburg effect in colon cancer via regulating PIAS3 expression
Authors: Pan Xiaolin , Feng Jin , Zhu Zhenhua , Yao Linhua , Ma Shijie , Hao Bo , Zhang Guoxin 
Published: July 2018

AbstractThis study aimed to investigate the relationship between the expression of microRNA (miR)‐181b, protein inhibitor of activated STAT3 (PIAS3) and STAT3, and to examine the function of the miR‐181b/PIAS3/STAT3 axis on the Warburg effect and xenograft tumour growth of colon cancer. Moreover, a positive feedback loop between miR‐181b and STAT3 that regulated the Warburg effect in colon cancer was explored. A luciferase reporter assay was used to identify whether PIAS3 was a direct target of miR‐181b. The gain‐of‐function and loss‐of‐function experiments were performed on HCT 116 cells to investigate the effect of miR‐181b/PIAS3/STAT3 on the Warburg effect and xenograft tumour growth of colon cancer, as determined by commercial kits and xenograft experiments. The relationship between the expression of miR‐181b, PIAS3 and STAT3 in HCT 116 and HT‐29 cells was determined using RT‐qPCR and Western blot. We found miR‐181b was a direct regulator of PIAS3. miR‐181b promoted the Warburg effect and the growth of colon cancer xenografts; however, these effects could be reversed by PIAS3. miR‐181b expression interacted with STAT3 phosphorylation in a positive feedback loop in colon cancer cells via regulating PIAS3 expression. In conclusion, this study for the first time demonstrated that miR‐181b contributed to the Warburg effect and xenograft tumour growth of colon cancer by targeting PIAS3. Moreover, a positive feedback loop between miR‐181b and STAT3 that regulated the Warburg effect in colon cancer was also demonstrated. This study suggested miR‐181b/PIAS3/STAT3 axis as a novel target for colon cancer treatment.
Sources of Social Influence on Adolescents’ Alcohol Use
Authors: Wesche Rose , Kreager Derek A. , Lefkowitz Eva S. 
Published: July 2018

The present research examines social influences on self‐reported frequency of drunkenness in a longitudinal sample of 1,439 adolescents (46% female, 90% White, mean age = 14 at baseline) with social network measures from friends, romantic partners, and romantic partners’ friends. We build on past research by addressing multiple mechanisms of social influence—peers’ frequency of drunkenness, alcohol‐related attitudes, and unstructured socializing—across relationship types. Adolescents’ drunkenness frequency increased when their friends’ and partners’ friends’ drunkenness frequency increased and when their romantic partners’ positive alcohol‐related attitudes increased. Furthermore, the association between unstructured socializing and frequency of drunkenness was stronger for older than younger adolescents. Results advance understanding of the social transmission of alcohol use in adolescence and inform intervention efforts.
Toward Interactive Social Neuroscience: Neuroimaging Real‐World Interactions in Various Populations
Authors: Minagawa Yasuyo , Xu Mingdi , Morimoto Satoshi 
Published: July 2018

AbstractHuman social activity is a continuous dynamic behavior consisting of live social signal exchanges; thus, studying interactions among multiple humans is critical to understanding social cognition. Indeed, social neuroscience focusing on such aspects—interactive social neuroscience—is an emerging field of interest. Functional near‐infrared spectroscopy (fNIRS) has played a significant role in accelerating this field by enabling real‐world neuroimaging for various populations. The present paper will first review previous hyperscanning studies using functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and electroencephalography (EEG). We will then summarize attempts and findings of fNIRS hyperscanning studies on social interaction in adult populations. Finally, we will review recent investigations of interactive social neuroscience in young populations and show preliminary results from a mother–infant hyperscanning study. These studies have predominantly revealed synchronized brain activities between humans and have identified conditions in which such inter‐personal connectivity was found to be increased. Furthermore, these studies suggest possible mechanisms of inter‐brain coupling: a process that recruits both mirror system and mentalization networks. Although fNIRS hyperscanning of infants remains limited, the reviewed literature demonstrates significant potential for fNIRS to disclose the interactive social brain and its development.