bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary bisphenol A concentrations in relation to asthma in a sample of Egyptian children
Authors: Youssef MM , El-Din EMS , AbuShady MM , El-Baroudy NR , Abd el hamid TA , Armaneus AF , El Refay AS , Hussein J , Medhat D , Latif YA 
Published: February 2018

Background: Bronchial asthma is one of the top disabling diseases in pediatrics. Limited research has been studied the association of the widely used plastic monomer bisphenol A (BPA) with childhood asthma. Objective: To compare the levels of urinary BPA in asthmatic and control children and to investigate the implication of BPA among other risk factors for the development of asthma. Subjects and methods: This case–control study included 97 children (45 asthmatic and 52 healthy controls) aged 3–8 years. Asthmatic children were diagnosed according to Global initiative for asthma (GINA) guidelines. Sociodemographic factors were assessed and urinary levels of BPA were determined in spot urine samples using high-performance liquid chromatography. The contribution of BPA among predictors for developing asthma was studied in asthmatic children. Results: Median total urinary BPA levels were significantly higher in asthmatic children than in control group (1.56 ng/mL in asthmatic children compared to 0.790 ng/mL in control group, p = 0.001). Children who had total urinary BPA levels >1.3 ng/mL were more likely to be asthmatic (odds ratio: 2.84, 95% confidence interval 1.22–6.59, p = 0.015). Multiple logistic regression analysis for predictors of asthma showed the importance of higher levels of BPA (>1.3 ng/mL) as a more significant predictor than passive smoking ( p = 0.006 for BPA categories vs. p = 0.049 for passive smoking). Conclusion: Association of higher levels of urinary BPA with the diagnosis of asthma in children may indicate the potential risk of BPA exposure in the precipitation of bronchial asthma. Further clinical and biochemical research are needed to clarify the proper mechanism explaining this association.
Extra, Extra, (Don't) Roll-off about It! Newspaper Endorsements for Ballot Measures
Authors: Fahey Kevin , Weissert Carol S. , Uttermark Matthew J. 
Published: February 2018

AbstractVoters often have difficulty making choices on the myriad state constitutional amendments they vote on each year. Without partisan cues, they turn to other sources for these low-salience, high complexity measures. One such source is newspaper endorsements. In this article, we look at newspaper endorsements of ballot measures in Florida over 20 years both on “no” votes and roll-off. We argue that endorsements' effect on “no” votes and roll-off differs in ways not previously appreciated. Newspaper endorsements have a positive impact on no votes, as expected from the information theory of voter participation. Endorsements have little impact on roll-off, which we posit is because roll-off voters are not likely to seek information from newspapers. Thus, newspaper endorsements serve to persuade, but not entice, voters to vote for ballot measures.
Measurement properties of the Dutch Unité Rhumatologique des Affections de la Main and its ability to measure change due to Dupuytren’s disease progression compared with the Michigan Hand outcomes Questionnaire
Authors: Broekstra Dieuwke C. , van den Heuvel Edwin R. , Lanting Rosanne , Werker Paul M. N. 
Published: February 2018

Data of a prospective longitudinal cohort study including 233 Dupuytren’s patients was used to determine: (1) whether the Unité Rhumatologique des Affections de la Main scale and Michigan Hand outcomes Questionnaire can detect change in hand function due to Dupuytren’s disease progression and to compare their abilities; (2) the concurrent validity, reliability, responsiveness and interpretability of the Dutch Unité Rhumatologique des Affections de la Main. The Unité Rhumatologique des Affections de la Main and Michigan Hand outcomes Questionnaire had comparable measurement properties, and were both able to distinguish participants with disease progression from those without progression (resp. U = 1252.5, p = 0.008, and U = 1086.0, p < 0.001), but only at a group level. Individual cases of progression could not be detected using these outcome measures, as indicated by the fact that the smallest detectable change was larger than the minimal important change, and area under the receiver operating curve (AUC) values of 0.75 for Michigan Hand outcomes Questionnaire and 0.67 for Unité Rhumatologique des Affections de la Main. Level of evidence: II
A Review of a Decade of Rugby Union Injury Epidemiology: 2007-2017
Authors: Viviers Pierre L. , Viljoen Jeandré T. , Derman Wayne 
Published: February 2018

Context: Rugby union is the most widely played team collision sport globally. As with other contact sports, there is substantial risk of injury. To date, the majority of studies on injury epidemiology have focused on elite male cohorts, which inherently prevents extrapolation of research findings to other groups within the player continuum. This review aims to describe emerging injury trends across the spectrum of various rugby union subpopulations and to highlight gaps that may influence future injury prevention tactics. Evidence Acquisition: Relevant articles published from 2007 to 2017 were obtained by searching MEDLINE, PubMed, and SPORT Discus. Studies on 15-a-side rugby union, implemented according to the 2007 consensus statement on injury definitions and data collection procedures for injuries in rugby union, were used. Study Design: Clinical review. Level of Evidence: Level 3. Results: Match injuries occur more frequently than training injuries. Injury rates increase consistently according to age and level of play. Severity of injury often is greater among lower levels of the game, and sex-specific differences relating to injury patterns and incidence rates exist. Conclusion: To date, a paucity of injury surveillance data exists for women and players of both sexes at all levels of community rugby union. Furthermore, the incidence of injuries and illnesses are poorly reported in epidemiological studies. Despite methodological differences, injury trends remain consistent throughout all levels of play.
A randomized study to evaluate the effect of exercise on fatigue in people with relapsing–remitting multiple sclerosis treated with fingolimod
Authors: Mäurer M , Schuh K , Seibert S , Baier M , Hentschke C , Streber R , Tallner A , Pfeifer K 
Published: February 2018

Background Fatigue is a major symptom of multiple sclerosis (MS) in patients, and it has been shown to improve with physical exercise. Although fingolimod might lessen fatigue, it is unclear how patients treated with fingolimod react to physical activity regarding fatigue. Objective This study evaluated the effect of an exercise intervention on fatigue in relapsing–remitting MS patients receiving fingolimod. Methods People with MS (PwMS) were randomized to either a structured internet-based exercise program (e-training) or no e-training intervention. The primary endpoint was the change in the Modified Fatigue Impact Scale (mFIS) after six months. Results The primary analysis showed no statistically significant difference between groups in the mFIS change. Subgroup analyses revealed a beneficial effect of physical exercise for PwMS with low aerobic capacity and with low aerobic capacity plus more severe fatigue. The incidence of adverse events was similar in both groups. No cardiovascular events were reported. The majority of PwMS were relapse free. Conclusion Physical exercise benefits on fatigue may depend on the physical capacity of the patient and requires individualized training. Consistent with previous studies, these results suggest that physical exercise generally does not impose a risk and that this holds true also for patients receiving fingolimod. Trial registration: ClinicalTrials.gov, NCT01490840.
Integration of Health Coaching Concepts and Skills into Clinical Practice Among VHA Providers: A Qualitative Study
Authors: Collins David A. , Thompson Kirsten , Atwood Katharine A. , Abadi Melissa H. , Rychener David L. , Simmons Leigh Ann 
Published: February 2018

Background Although studies of health coaching for behavior change in chronic disease prevention and management are increasing, to date no studies have reported on what concepts and skills providers integrate into their clinical practice following participation in health coaching courses. The purpose of this qualitative study was to assess Veterans Health Administration (VHA) providers’ perceptions of the individual-level and system-level changes they observed after participating with colleagues in a 6-day Whole Health Coaching course held in 8 VHA medical centers nationwide. Methods Data for this study were from the follow-up survey conducted with participants 2 to 3 months after completing the training. A total of 142 responses about individual-level changes and 99 responses about system-level changes were analyzed using content analysis. Results Eight primary themes emerged regarding individual changes, including increased emphasis on Veterans’ values, increased use of listening and other specific health coaching skills in their clinical role, and adding health coaching to their clinical practice.Four primary themes emerged regarding system-level changes, including leadership support, increased staff awareness/support/learning and sharing, increased use of health coaching skills or tools within the facility, and organizational changes demonstrating a more engaged workforce, such as new work groups being formed or existing groups becoming more active. Conclusions Findings suggest that VHA providers who participate in health coaching trainings do perceive positive changes within themselves and their organizations. Health coaching courses that emphasize patient-centered care and promote patient–provider partnerships likely have positive effects beyond the individual participants that can be used to promote desired organizational change.
RETRACTED ARTICLE: hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway
Authors: Yin Na , Wang Yanlin , Lu Xueyan , Liu Ranran , Zhang Lianshuang , Zhao Wei , Yuan Wendan , Luo Qianqian , Wu Hao , Luan Xiying , Zhang Hongqin 
Published: February 2018

Abstract
Background
Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF). But the exact mechanism remains unclear. The goal of the present study is to investigate the role of immune factors (T-helper 17 (Th17), cytotoxic T (Tc17) and regulatory T (Treg) cells) in the recovery of ovarian function and whether the phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway is involved in the regulation.

Methods
The inhibitor of PI3K/Akt was administered to observe its effect on ovarian function recovery and immune regulation. Serum levels of estradiol (E2), follicle stimulation hormone (FSH), luteinizing hormone (LH) and anti-Müllerian hormone (AMH)) and anti-Zona pellucida antibody (AZPAb) were measured by ELISA to evaluate ovarian function. The morphological changes of ovaries were observed by HE staining. Apoptosis of granular cells (GCs) was determined by detecting the expression of capase-3. Expression of p-Akt protein was detected by immunohistochemistry and western blot assay in ovarian tissues. The MTT assay was performed to assess GC proliferation. GC apoptosis was performed using flow cytometry analysis. Percentages of Th17, Tc17 and Treg cells were detected by flow cytometry. Expression of interleukin (IL)-17 in serum was measured by ELISA.

Results
LY294002 administration decreased serum levels of E2 and AMH, while the levels of FSH, LH and AZPAb in serum were increased compared with mice in the hPMSC transplantation group. The ovarian morphology presented as atrophy and fibrosis, with functional follicles exhausted. The expression of p-Akt in ovarian tissue was significantly decreased. Also, LY294002 administration significantly decreased proliferation and increased cell apoptosis in GCs, and for immune factors the ratios of Th17/Tc17 and Th17/Treg cells were significantly increased, as well as the serum levels of IL-17.

Conclusions
Our data suggest that the PI3K/Akt signal pathway is involved in the recovery of ovarian function by changing the ratios of Th17/ Tc17 and Th17/Treg cells in POF mice following hPMSC transplantation.
Community treatment orders: an analysis of the first five years of use in England
Authors: Trevithick Liam , Carlile Jane , Nodiyal Sunil , Keown Patrick 
Published: February 2018

BackgroundCommunity treatment orders (CTOs) were introduced in England in 2008.AimsTo measure the rate of CTO use in England during the first 5 years following introduction.MethodThe number of involuntary detentions and CTOs in National Health Service (NHS) hospital trusts was collected between 2009 and 2014. Rates of CTO use and the ratio of CTOs to detentions on admission were calculated, and how these varied between trusts.ResultsThe number of new CTOs each year ranged between 3834 and 4647. The number subject to a CTO per 100 000 population increased from 6.4 in 2009/10 to 10.0 in 2013/14. There was variation between NHS trusts in the use of CTOs when compared with the number of involuntary detentionsConclusionsThe number of patients on CTOs increased year on year. Those on forensic sections were more likely to be discharged on a CTO than those on civil sections. There was considerable variation in the pattern of use between hospitals.Declaration of interestNone.
Synthesis of Ferrocene-Fused Pyrans through Alkynoxy-Directed C–H Activation/Cyclization
Authors: Mitsui Takashi , Tokoro Yuichiro , Haraguchi Ryosuke , Sugita Kengo , Harada Masato , Fukuzawa Shin-ichi , Minami Yasunori , Hiyama Tamejiro 
Published: February 2018

Abstract
We have developed palladium-catalyzed C–H activation and cyclization of alkynyl ferrocenyl ethers with various alkynes, providing ferrocene-fused pyran derivatives. As a preliminary result, we also achieved the asymmetric version of this reaction with high enantioselectivity, providing the first example of the catalytic asymmetric synthesis of an enantio-enriched ferrocene-fused oxacycle.
Causal pathways of intergenerational poverty transmission in selected EU countries
Authors: Papanastasiou Stefanos , Papatheodorou Christos 
Published: February 2018

The paper investigates whether, in what way and to what extent the family of origin affects offspring’s poverty risk in selected EU countriesrepresenting different social protection systems. Employing logit models and utilizing EU-SILC data, the analysis brings to the forefront the importance of social protection for intercepting the intergenerational transmission of poverty. Denmark with the socialdemocratic welfare state is the most successful in mitigating the effect of the family of origin on offspring’s poverty risk, followed by France representing the conservative-corporatist welfare regime. Less effective οn this matter appear to be Greece and Great Britain representing the south-European and the liberal social protection system respectively.
Preparation / Allocation / Habituation: The Holistic Approach to Migrant Exclusion
Authors: Xypolytas Nikos 
Published: February 2018

The article establishes a theoretical approach to migrant exclusion based on recent research and focuses on the importance of the experience and organization of work. The holistic approach recognizes three importantstages in the process of exclusion: i) the preparation of future migrants in the country of origin through the integration and cultural acclimatization to casual and low-status work, ii) the allocation of migrant workers in low-status jobs in the host countries and iii) the habituation of migrantworkers to the characteristics and demands of their work which leads to the reproduction of their social position.
Expanding the Abortion Provider Workforce: A Qualitative Study of Organizations Implementing a New California Policy
Authors: Battistelli Molly Frances , Magnusson Sara , Biggs M. Antonia , Freedman Lori 
Published: February 2018

AbstractCONTEXTAccess to abortion care in the United States varies according to multiple factors, including location, state regulation and provider availability. In 2013, California enacted a law that authorized nurse practitioners (NPs), certified nurse‐midwives (CNMs) and physician assistants (PAs) to provide first‐trimester aspiration abortions; little is known about organizations’ experiences in implementing this policy change.METHODSBeginning 10 and 24 months after implementation of the new law, semistructured interviews were conducted with 20 administrators whose five organizations trained and employed NPs, CNMs and PAs as providers of aspiration abortions. Interview data on the organizations’ experiences were analyzed thematically, and facilitators of and barriers to implementation were identified.RESULTSAdministrators were committed to the provision of aspiration abortions by NPs, CNMs and PAs, and nearly all identified improved access to care and complication management as clear benefits of the policy change. However, integration of the new providers was uneven and depended on a variety of circumstances. Organizational disincentives included financial and logistical costs incurred in trying to deploy and integrate the different types of providers. Some administrators found that increased costs were outweighed by improved patient care, whereas others did not. In general, having a strong administrative champion within the organization made a critical difference.CONCLUSIONSCalifornia's expansion of the abortion‐providing workforce had a positive impact on patient care in the sampled organizations. However, various organizational obstacles must be addressed to more fully realize the benefits of having NPs, CNMs and PAs provide aspiration abortions.
The Effect of Single Mismatches on Primer Extension
Authors: Rejali Nick A , Moric Endi , Wittwer Carl T 
Published: February 2018

AbstractBACKGROUNDAllele-specific PCR is an important diagnostic tool that identifies single-nucleotide variants by preferential amplification of a particular allele, using primers that are mismatched to all but one allele variant.METHODSWe applied a fluorescent stopped-flow polymerase assay to measure extension rates from oligonucleotide hairpins to simulate primer–template pairs. Under PCR-applicable conditions, reaction rates were recorded in nucleotides per second per polymerase (nt/s/poly). The effects of temperature, potassium chloride, mismatch type, and position were studied with primarily a deletion mutant of Thermus aquaticus (Taq) DNA polymerase and 135 oligonucleotide sequences.RESULTSRates at 65 °C were between 205 ± 11 and 177 ± 8 nt/s/poly for matched templates and between 4.55 ± 0.21 and 0.008 ± 0.005 nt/s/poly for 3′-mismatched templates. Although extension rates progressively increased with mismatches further away from the 3′ end, rates were still reduced by as much as 84% with a C · C mismatch 6 bases from the 3′ end. The optimal extension temperature for matched sequences was 70 °C, shifting to 55–60 °C for 3′ mismatches. KCl inhibited mismatch extension. The Michaelis constant (Km) was increased and the apparent unimolecular rate constant (kcat) decreased for 3′ mismatches relative to matched templates.CONCLUSIONSAlthough primer extension of mismatches depends on mismatch type and position, variation also depends on local sequence, KCl concentration, and the type of polymerase. Introduction of 3′ mismatches reduces the optimal temperature for extension, suggesting higher annealing temperatures for better allele discrimination. Quantitative descriptions of expected specificity in allele-specific PCR provide additional design direction and suggest when other methods (e.g., high-resolution melting analysis) may be a better choice.
Hyper Zagreb indices of composite graphs
Authors: Devi Sharmila , Kaladevi V. 
Published: February 2018

For a (molecular) graph, the first Zagreb index M1 is equal to the sum of squares of the degrees of vertices, and the second Zagreb index M2 is equal to the sum of the products of the degrees of pairs of adjacent vertices. Similarly, the hyper Zagreb index is defined as the sum of square of degree of vertices over all the edges.Â In this paper, First we obtain the hyper Zagreb indices of some derived graphs and the generalized transformations graphs. Finally, the hyper Zagreb indices of double, extended double, thorn graph, subdivision vertex corona of graphs, Splice and link graphs are obtained.
An Extract of Zingiber officinale and Piper retrofractum Combination and Its Effect to Cancer Cell Line
Authors: Ekowati Heny , Septiyaningsih Septiyaningsih , Harwoko Harwoko 
Published: February 2018

Chemotherapy may emerge side-effect since it may treat inconveniently the synthesis of nucleic acids and proteins, both cancer cells or normal cells. Plants as a cancer therapy were expected to reduce this toxicity and side effects. Plants which used empirically for cancer therapy was Zingiber officinale cv. Rubrum and Piper retrofractum. This study was conducted to examine the cytotoxic activity of ethanolic extract combination of two plants in HeLa and T47D cell lines. Zingiber officinale cv. Rubrum, Piper retrofractum and mixture (1:1) powdered then macerated with 96% ethanol for 3 x 24 hours. Identification of the constituent that had potential anticancer effect was used TLC with silica GF 254 as stationary phase, cytotoxic activity was examined by yellow MTT assay, then analyzed using probit. Apoptotic assay was performed by immunofluororescence method, using fluorochromes ethidium bromide and acridine orange. The result showed that Zingiber officinale cv. Rubrum contains terpenoids, while Piper retrofractum contains alkaloids substance. The mixture showed cytotoxic activity against HeLa and T47D cell with IC50 33 and 53 µg/mL respectively. The extract caused cytotoxic effect through apoptotic mechanism.Keywords : Zingiber officinale cv. Rubrum, Piper retrofractum, cytotoxic, HeLa cells, T47D cells