bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics of Warfarin Following Intravenous Administration to Man
Authors: O’Reilly R. A , Welling P. G , Wagner J. G 
Published: June 2018

SummaryNine sets of plasma concentration, time data, observed following rapid intravenous injection of sodium warfarin to human subjects, were fit well by the equation appropriate to the two compartment open model. The average value of the forward distribution rate constant (K1) was 0.700 h-1 (standard deviation 0.623 h-1); the average value of the reverse distribution rate constant (K-1) was 1.09 h-1 (S.D. 0.583 h-1); the average value of the loss rate constant (K2) was 0.0362 h-1 (S.D. 0.015 h-1); and the average volume of the inner compartment, of which plasma is assumed to be representative, was 4.72 1 (S.D. 0.989 1) corresponding to an average of 7.18% of body weight (S.D. 1.46). These data indicate that in the dose range studied, 50 to 600 mg of sodium warfarin, there is no evidence of dose-dependent kinetics of warfarin in man.
Studies on Thrombolysis with Streptokinase
Authors: Gottlob R , Stockinger L , Pötting U , Schattenmann G 
Published: June 2018

SummaryIn vitro whole blood clots of various ages, experimental thrombi produced in the jugular vein of rabbits and human thrombi from arteries and veins were examined in semi-thin sections and by means of electron microscopy.In all types of clots examined a typical course of retraction was found. Retraction starts with a dense excentrical focus which grows into a densification ring. After 24 hours the entire clot becomes almost homogeneously dense; later a secondary swelling sets in.Shortly after coagulation the erythrocytes on the rim of the clot are bi-concave discs. They then assume the shape of crenate spheres, turn into smooth spheres and finally become indented ghosts which have lost the largest part of their contents. In the inner zone, which makes up the bulk of the clot, we observed bi-concave discs prior to retraction. After retraction we see no crenations but irregularly shaped erythrocytes. Once the secondary swelling sets in, the cross-section becomes polygonal and later spherical. After extensive hemolysis we observe the “retiform thrombus” made up of ghosts.Experimental and clinical thrombi present the same morphology but are differentiated from in vitro clots by: earlier hemolysis, immigration of leukocytes, formation of a rim layer consisting of fibrin and thrombocytes, and the symptoms of organization. Such symptoms of organization which definitely will prevent lysis with streptokinase were found relatively late in experimental and clinical thrombi. Capillary buds and capillary loops were never found in clinical thrombi prior to the third month.The morphological findings agree with earlier physical and enzymatic investigations. The observation that phenomena of reorganization occur relatively late and frequently only in the rim areas of large thrombi explains why lytic therapy is possible in some of the chronic obliterations.
Physico-Chemical and Immunological Properties of Bovine Hageman Factor
Authors: Grammens G. L , Prasad A. S , Mammen E. F , Barnhart M. I 
Published: June 2018

SummaryBy using glass wool absorption followed by elution in strong salt solution and various precipitation methods and DEAE cellulose column chromatography, Hageman factor was purified from bovine plasma. Physico-chemical properties were studied in native protein and in 6 M urea (denatured) which was used in order to prevent monomer - polymer conversion. S°20,w was 7.07 in 0.1 M KC1 and 5.84 in 6 M urea. The intrinsic viscosity by Kragh’s method was 0.0540 ml/g inNaCl-phosphate buffer and 0.0815 ml/g in 6 M urea. Partial specific volume (v) by method based on amino acid residues in undenatured protein, was 0.724 cc/g. By using differential sedimentation equilibrium in 6 M urea-H20 and 6 M urea - D20 solution, v was determined as 0.740 cc/g. In urea, molecular weight (MW) was 142,000 as determined by meniscus depletion method. Similar values were obtained for nondenatured and denatured protein by Sephadex gel filtration, from amino acid composition using Brand’s method and Schachman’s equation. For undenatured and denatured Hageman factor, molar frictional ratios (f/fo) were 1.39 and 1.58, axial ratios were 5.0 and 7.0 and estimation of diffusion constant (D°20, w) based on S-rate, MW and v, gave values of 4.45 x 10-7 and 3.88 x 10-7 cm2/sec respectively. Our data indicate that the molecule was unfolded in 6 M urea solution. Two N-terminal groups, glycine and valine, were demonstrated by Edman procedure. Carbohydrate analysis revealed the following: hexosamine 0.8%, protein- bound hexose 1.9%, fucose 0.19% and sialic acid 0.35%. Isoelectric point was determined as 7.9 by electrofocussing technique. This protein migrated with gamma globulin on electrophoresis. Hageman factor was found to be a powerful immunogen. Anti Hageman factor reacted with both a plasma and a serum protein but not with purified IgG.
Factor IX-Inhibitors
Authors: Lechner K 
Published: June 2018

Summary1. Two patients with severe hemophilia B and an acquired inhibitor against factor IX are described.2. The inhibitors inactivate factor IX irreversibly. The speed of inactivation is very fast and cannot slowed down by dilution of the inhibitor or by lowering of the incubation temperature. Factor IX of serum is inactivated to a higher degree than factor IX of plasma. Factor IX inhibitors are more sensitive to dilution than factor VIII inhibitors.3. The inhibitor protein is eluted from the Sephadex G-200 column with the G-peak. On Chromatography on DEAE-cellulose two activity peaks are obtained.4. Immunologically the inhibitors belong predominantly to the immune globulins of the G-class, but it cannot be excluded that the activity is also associated with IgA. As light chains kappa chains were found in one case.
A Study of Proteolytic and Fibrinolytic Factors in the Human Prostate
Authors: Nijs Michelle , Brassinne Christiane , Coune A , Tagnon H. J 
Published: June 2018

SummaryAn analysis of the proteolytic factors contained in human prostatic tissue was performed in vitro. Casein, fibrinogen and fibrin, non-radioactive and radioiodinated were used as substrates.A first factor, called direct proteolytic activity, capable of proteolyzing casein without prior activation, is described. It had no effect on fibrinogen or fibrin, was inhibited by epsilon aminocaproic acid, but not by the soybean trypsin inhibitor. This shows that this proteolytic activity was quite different from plasmin.A second factor, called plasminogen proactivator, was demonstrated on bovine plasminogen in the presence of streptokinase, the latter being unable to produce direct activation of bovine plasminogen. Activation of this system resulted in the transformation of plasminogen into plasmin, capable of digesting casein as well as fibrinogen and fibrin. Epsilon aminocaproic acid and the soybean trypsin inhibitor inhibited this system. The properties of this proactivator show that it probably does not result from the presence of small amounts of plasminogen in the prostate. Urokinase, a factor present in human urine, is able to activate this proactivator under certain conditions.The third factor, called plasminogen activator, was capable of activating directly human plasminogen into plasmin. It was not active on bovine plasminogen. Epsilon aminocaproic acid and the soybean trypsin inhibitor were effective inhibitors. Addition of large volumes of human prostatic extract to human plasminogen resulted in a paradoxical decrease of the proteolytic activity suggesting the possible existence in the prostate of an inhibitor of this third factor.Possible relationships between these factors and the clinical state of fibrinolysis observed in some cases of disseminated prostatic cancer are discussed.
The Evaluation of the Two-Stage Prothrombin Assay
Authors: Hemker H. C , Hemker P. W , Torren K. v. d , Devilee P. P , Hermens W. Th , Loeliger E. A 
Published: June 2018

SummaryIt is shown that (and why) the traditional ways of evaluating a thrombin generation curve do not give acceptable estimations of the prothrombin content of the sample. An alternative method is shown to meet the requirements better; it consists of drawing the thrombin generation curve on a semi-logarithmic graph, and extrapolating the descending slope to zero time. This gives a thrombin concentration representing the prothrombin concentration of the original sample.
A Rapid Method for the Semiquantitative Determination of Fibrinogen and Fibrinogen Degradation Products (FDP) in Defibrination Syndrome
Authors: Sas G , Jákó J , Domán J , László C , Pádár J 
Published: June 2018

Summary1. It was found that effects of deliberate changes in fibrinogen concentration and in the amount of FDP added to the experimental system (containing pure fibrinogen solution and saline- or serumdiluted plasma) could be approximated with satisfactory accuracy by a linear plot of the logarithm of clotting times versus the inverse of fibrinogen concentration.By increasing FDP activity the slope of the obtained lines becomes proportionately steeper. The constants, which interrelate clotting time, fibrinogen concentration and FDP activity, are to be derived experimentally. The obtained formula is expressed also nomographically.2. Apart from the presence of some very rare anticoagulants, an elongation of thrombin time observed under strictly specified conditions points to a substantial reduction of fibrinogen concentration and/or an interplay of fibrinogen degradation products.If a definite amount of fibrinogen (Fibrinogen sec. Warner Chilcott) is admixed to a pathological plasma, thrombin time in the latter will decrease in a specifiable manner. By entering the original and corrected thrombin time values in the reported nomogram the fibrinogen content and FDP activity of the pathological plasma can be calculated.3. The described procedure for fibrinogen and FDP assay is suitable first of all in acute defibrination syndrome and at the thrombolytic therapy. Its agreement with the results obtained by immunodiffusion was satisfactory as regards the fibrinogen in plasmas of different fibrinogen concentration.
Diospyros kaki Cr. and Climate Changes
Authors: Creveld Marijke 
Published: June 2018

Abstract
Diospyros kaki Cr. as a homeopathic remedy was made from the Kaki tree from Nagasaki, Japan, that survived the 1945 Plutonium bomb attack on the city during the war between Japan and the USA. Two short cases show the remedy can be used for climate change–related indications, namely skin cancers and post-traumatic stress disorder.
The Process of Building the Repertory and a Glance to the Roads Ahead: Discussion with Roger Van Zandvoort
Authors: Tagori Yossi 
Published: June 2018

SummaryThis article concerns an interview with Roger van Zandvoort, author of ‘Complete Repertory and Dynamic Repertory’. In some parts, it is referring to an article I published in Vol. 2, 2017, of Homeopathic Link ‘Call for a New Concept of Homeopathic Software’. The parts concerned are those dealing with the future development of the homeopathic software, and especially the possibility to have in future software that will enable colleagues worldwide to share their data and the way these data can contribute to future repertories.
Treating Sickle Cell Disease in Africa
Authors: Achieng Benta , Akpabio Elton , Balikwisha Joseph , Omondi Monica , Hongo Yuanita , Chappell Peter , van der Zee Harry 
Published: June 2018

SummarySickle cell disease (SCD) is a condition causing lots of complications and suffering. In the past decades, treatment modalities have been developed that increase life expectancy and the quality of life of SCD patients. In Africa, these are not available, resulting in SCD patients to die young after many hospitalisations for serious and often painful crises. A new homeopathy-based remedy for SCD has been used with good results since 2013.
Usefulness of Preoperative Simulation in Skull Base Approach: A Case Report
Authors: Kolakshyapati Manish , Abiko Masaru , Mitsuhara Takafumi , Takeda Masaaki , Shrestha Tejashwi , Kurisu Kaoru , Ikawa Fusao 
Published: June 2018

AbstractSkull base approach is a neurosurgical challenge requiring dexterity of the operating surgeon for good postoperative outcome. In addition to the experience of the operating surgeon, adequate preoperative information of the tumor is necessary to ensure better outcome. In clinoid meningioma, it is sometimes difficult to determine its relationship with the surrounding structure and the feeding artery. Previously, preoperative simulation has been utilized to determine the intracranial course of the compressed nerves in relation to the petroclival meningioma. We report a case of clinoid meningioma where preoperative fusion of three dimensional computed tomography angiography (3D-CTA) and 3T-fast imaging employing steady-state acquisition (FIESTA) images was useful in determining the exact location of the feeding artery to devascularize the tumor and aid in surgery. Preoperative simulation with three-dimensional digital subtraction angiography (3D-DSA) and 3T-FIESTA fusion images can be a useful adjunct tool to supplement surgery and to train neurosurgical trainees.
High-Definition Video Recording: Taking Sport Technology to the Operating Room
Authors: de Sierra C. , Cuenca-Castillo J. , Estevez-Cid F. 
Published: June 2018

AbstractFilming surgeries for teaching purposes, publications, and patient records has become increasingly popular as the systems for digital recording have evolved, becoming high-quality systems, both smaller and lighter. Digital recording allows long-term storage, retrieval, and database organization. In addition, sharing digital contents has also become easier since video sharing sites and social networks make it possible to upload these contents onto the Internet. We describe a simple and economical system for surgeons to record surgeries in high definition under sterile conditions without any interference with the surgeon's line of vision.
Risk of Recurrent Venous Thromboembolism in Autoimmune Diseases: A Systematic Review of the Literature
Authors: Leeuw Karina , Rutgers Abraham , Meijer Karina , Tichelaar Vladimir , Borjas-Howard Jaime 
Published: June 2018

AbstractDespite an abundance of literature on the risk of a first venous thromboembolic event (VTE) in autoimmune diseases, specific recommendations about managing VTE in autoimmune diseases are lacking. This article aimed to collect evidence on the risk of recurrent VTE in patients with autoimmune diseases. The authors searched PubMed/Embase for studies including patients with VTE and autoimmune diseases as an exposure or studies including patients with autoimmune diseases in which recurrent VTE was one of the outcomes. Eleven articles were selected from 4,739 unique abstracts. Of the 11 studies, 3 reported time-dependent rates. Two studies collected rates of recurrence in Behcet's disease, reporting a 5-year recurrence risk between 35 and 40%. However, the 5-year recurrence risk was lower than 10% in patients treated with immunosuppressant medication, while two studies suggested frequent recurrence in patients on only anticoagulant therapy. The other study reporting time-dependent incidence concerned patients with inflammatory bowel disease and index VTE. The 5-year risk of recurrent VTE was 33.4%, yielding a hazard ratio of 1.7 versus controls. All studies were retrospective and therefore risk may overestimate recurrence risk in comparison with known prospective cohort studies. There are insufficient data to make confident recommendations about the management of recurrent VTE prevention in patients with autoimmune diseases in general. The overall VTE risk profile, lower effectiveness of anticoagulants, and the observation that immunosuppression lowered risk of recurrence in patients with Behcet's disease seem to warrant immunosuppressant therapy over anticoagulation as a first consideration when preventing VTE recurrence in these patients.
Cardiac Graft from Donors with Extracorporeal Support—A Report of Two Cases
Authors: Panholzer Bernd , Huenges Katharina , Cremer Jochen , Haneya Assad 
Published: June 2018

AbstractThe persistent global shortage of organ donors is still a major limitation for transplantation. Experiences of heart transplantation from donors with extracorporeal support are rare. Here, we report from two cases of donors who were supported by extracorporeal membrane oxygenation due to acute circulatory failure. In both cases, the direct postoperative course was uneventful and free from major complications. The patients were discharged to a rehabilitation clinic. Our experience suggests that the use of heart organ from carefully selected donors with extracorporeal support is possible and may lead to an excellent outcome.
Neurological Sequelae due to Inborn Metabolic Diseases in Pediatric Refugees: Challenges in Treating the Untreated
Authors: Schiergens Katharina , Staudigl Michael , Borggraefe Ingo , Maier Esther 
Published: June 2018

AbstractIn the 2015 mass migration from Syria and neighboring countries, Germany received an unprecedented number of 4,76,649 asylum applications. As many of the refugees arrived in Southern Germany via the Austrian border, the city of Munich was faced with the majority of Germany's inflow of war refugees and their complex health issues. Among the refugees were a high number of children. Their main health issues were infectious diseases and surgical procedures due to trauma, but we also encountered complex chronic diseases. This report describes clinical history, signs and symptoms, diagnostics, and treatment of six pediatric patients with untreated inborn errors of metabolism (IEM): phenylketonuria, biotinidase deficiency, HMG-CoA lyase deficiency, mucopolysaccharidosis type II, and mucopolysaccharidosis type VI. Since early diagnosis and treatment is essential in IEM, both delayed diagnosis and inadequate therapy in refugee children may lead to significant brain injury, organ damage, and even death. Severe neurological sequelae in both phenylketonuria and HMG-CoA lyase deficiency could have been prevented by newborn screening. Screening programs are necessary to improve the prognoses for refugee children. European Union governments and involved health care systems should pursue early diagnosis and treatment in pediatric refugees regarding IEM to prevent neurological long-term sequelae.
Direct Excision of the Lower Eyelid: A Safe and Effective Method for Treating Dermatochalasis and Pigmentation
Authors: Glasgold Robert , Rabach Lesley , Glasgold Mark , Rogal Joelle 
Published: June 2018

AbstractThe subciliary and skin pinch approaches are the most widely accepted techniques for treating dermatochalasis of the lower eyelid. Direct excision (DE) is an accepted method for treating festoons; however, it is not a popular technique for the treatment of dermatochalasis and pigment of the lower lid. DE of the lower lid offers a safe and excellent aesthetic result for dermatochalasis and pigment of the lower lid, without causing lower lid malposition, which can occur with more traditional methods. In addition to being able to remove significantly more skin without risking lower lid malposition, this procedure allows for removal of the most pigmented and poorly textured skin overlying the nasojugal groove. It is an effective alternative to the conventional subciliary and skin pinch approaches.
Language choices and practices of migrants in Germany
Authors: Fiedler Sabine , Wohlfarth Agnes 
Published: June 2018

AbstractThe language uses of twenty migrants in Germany who have English in their language repertoires are investigated through semi-structured interviews and qualitative content analysis. The findings suggest that in occupation-related situations and daily life, these migrants resort to English in situations that are too difficult to handle in German. For most of them this is only temporary, before they have a sufficient command of German. Whether and how well migrants learn German depends on factors such as the planned length of stay, the demand for the language in their professional field, previous migration experiences, and personality. Most of the interviewees had taken language classes and were highly motivated to learn German, as English is not always a viable option for communication in Germany and because they considered proficiency in German a sign of respect. The use of German and English as a lingua franca were the two major mediation strategies, along with language technologies like Google Translate, while some interviewees reported successful use of intercomprehension.
Exploring the construction of the Irish Mammy in ‘Mrs Brown’s Boys’
Authors: Murphy Bróna , Palma-Fahey María 
Published: June 2018

Abstract
This paper explores how the cultural concept of the Irish Mammy is portrayed in the popular television comedy series ‘Mrs Brown’s Boys’. Considering the historicity and cultural aspects surrounding essential views of Irishness that have shaped the archetype of the stereotype, we draw on a corpus of (semi)scripted fictional interaction taken from the series. Using a Corpus Assisted Discourse Studies (CADS) approach to explore linguistic patterning surrounding the use of key lexical markers (e.g. Mammy), we investigate what they reveal about how the concept is represented, (de)constructed, and negotiated. The paper discusses the construction and deconstruction of the stereotype and the extent to which it draws on shared knowledge to reflect and navigate particular cultural values and concerns (Hall 1997; Hall et al. 2013). It views the deconstruction, in particular, as a way of challenging the traditional stereotype, in light of societal change, to provide a more layered, realistic and multi-faceted insight into the identities of the Irish Mammy figure within the fictional context of Mrs Brown’s Boys.
Preludeas lifespan gauge
Authors: Thomson David 
Published: June 2018

AbstractThrough multiple versions ofPrelude, readers can follow the progress of a poem 41 years in the making, a period that exceeds by far the timeline of its narration. To do so I employed automated analysis platforms LIWC (Pennebaker, Chung, Ireland, Gonzales, & Booth, 2007a) and SEANCE (Crossley, Kyle, & McNamara, 2016). Results reveal that Wordsworth exhibited habits of mind resonant with maturation, especially in his increased positivity and abstraction. Discriminant function analysis revealed four psychological markers that almost completely identified shifts between editions. Indices connoting trust and sadness, as well as positive adjectives and the cognitive indicator of exclusion, accounted for 63 percent of the variance. The study offers a methodology for considering multiple versions of any text in which the passage of time becomes an important marker. I present these findings within a digital humanities framework and conclude by discussing applications.
The Bride
Authors: Fardjam Farideh 
Published: June 2018

Farideh Fardjam (b. 1935) is an accomplished Iranian playwright. After receiving her early education in Iran, she spent several years studying in France. She then returned to Iran and obtained her B.A. degree in Persian literature from the University of Tehran.Fardjam has been writing plays since 1961. Her interests also center on children's stories. Ten of her stories on traditional Iranian themes have already been published. Fardjam has been living in Amsterdam since the early 1970s where she has been active in the public relations division of the Dutch Radio and Television. She has prepared several documentary films including a film on Iranian women during the revolution.The Bride has been produced and shown in both Iran and the United States. The play was shown on the Iranian television in the early 1960s with a noted cast that included Khorvash, Safavi, Nasirian, and Entezami.