Abstract 4258: Preliminarily results of the Oncohabitats Study: A multicentre validation of overall survival (OS) estimation of patients with glioblastoma (GBM) using vascular biomarkers
Authors: Álvarez-Torres María del Mar , Bellvís–Bataller Fuensanta , Juan–Albarracín Javier , Fuster–Garcia Elies , Estellés David Lorente , Reynes Gaspar , Aparici-Robles Fernando , Botella Carlos , Muñoz-Langa Jose , Faubel Raquel , Asensio-Cuesta Sabina , García–Ferrando Germán Adrían , Auger Cristina , Rovira Alex , Pineda Jose , Mora Jaime Font de , Mollà-Olmos Enrique , Revert-Ventura Antonio José , Tshibanda Luaba , Martin Didier , Crisi Girolamo , Emblem Kyrre Eeg , Due-Tonnessen Paulina , Meling Torstein R , García-Gómez Juan M 
Published: August 2019

Abstract
We report preliminarily results of an international retrospective study (NCT03439332) analyzing the prognostic value of the early assessment of vascular architecture of glioblastoma (GBM).
The initial cohort included 300 pts treated at 7 European hospitals. Multiparametric images were processed by Oncohabitats (www.oncohabitats.upv.es) to obtain the cerebral blood volume (CBV) and cerebral blood flow (CBF) from 4 automatically delimited regions of interest (ROIs): high angiogenic tumor (HAT), low angiogenic tumor (LAT), infiltrating peripherial edema (IPE), and vasogenic peripherial edema (VPE). Uniparametric Cox regression models and Kaplan-Meier analysis were developed to test prognostic and stratification capabilities of each biomarker.
115 pre-surgical MRIs passed quality controls and were included in the analysis. Median follow up was 12.9 months (m) (IQR: 9.2-17.6). 73 pts (63.5%) were male. 54 pts (47%) underwent total resection; 84 pts (73%) received adjuvant temozolomide. Median OS was 13.6 m (95%CI:12.1-15.2). Cox regression analysis yielded a significant correlation between OS and maximum rCBV and rCBF in HAT and LAT (Table), independent of the extent of resection. Median OS by Kaplan-Meier analysis in patients with high and low vascularity is shown in the Table.
Our preliminarily results shows that patients with lower vascularity (rCBV or rCBF) in vascular habitats inside enhancing tumor region (HAT and LAT) is associated with higher OS, and could improve patient stratification. Our results are consistent with our pilot study [1], Validation in large multicentric studies is underway.
COX REGRESSION ANALYSISKAPLAN-MEIER STRATIFICATION ANALYSISCOX REGRESSION ANALYSISKAPLAN-MEIER STRATIFICATION ANALYSISHAZARD RATIO95% CONFIDENCE INTERVALP-VALUE*NUMBER OF PATIENTSMEDIAN SURVIVAL (months)P-VALUErCBV máximumHigh Angiogenic Tumor10.339[1.09- 1.14]0.0202*[29 86][16.66 12.78]0.004***Low Angiogenic Tumor10.485[1.17- 1.31]0.0262*[29 86][17.10 12.78]0.002***Infiltrating Peripheral Edema0.9835[1.30- 1.71]0.1208[29 86][14.60 12.91]0.119Vasogenic Peripheral Edema0.7942[1.14- 1.63]0.6046[29 86][15.23 12.91]0.220rCBF máximumHigh Angiogenic Tumor0.9997[1.02- 1.03]0.1077[47 68][14.93 11.65]0.009**Low Angiogenic Tumor10.411[1.21- 1.40]0.0384*[29 86][15.56 12.75]0.016*InfiltratingPeripheral Edema0.8923[1.35- 2.04]0.2589[29 86][15.23 12.83]0.394Vasogenic Peripheral Edema0.6846[1.11- 1.81]0.7447[29 86][14.60 12.96]0.508Table: Results of Cox-regression and Kaplan-Meier analysis. (P VALUE*: False discovery rate corrected.)[1]: https://doi.org/10.1148/radiol.2017170845
Citation Format: María del Mar Álvarez-Torres, Fuensanta Bellvís–Bataller, Javier Juan–Albarracín, Elies Fuster–Garcia, David Lorente Estellés, Gaspar Reynes, Fernando Aparici-Robles, Carlos Botella, Jose Muñoz-Langa, Raquel Faubel, Sabina Asensio-Cuesta, Germán Adrían García–Ferrando, Cristina Auger, Alex Rovira, Jose Pineda, Jaime Font de Mora, Enrique Mollà-Olmos, Antonio José Revert-Ventura, Luaba Tshibanda, Didier Martin, Girolamo Crisi, Kyrre Eeg Emblem, Paulina Due-Tonnessen, Torstein R Meling, Juan M García-Gómez. Preliminarily results of the Oncohabitats Study: A multicentre validation of overall survival (OS) estimation of patients with glioblastoma (GBM) using vascular biomarkers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4258.