bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomorphic microchanneled electrodes for enhanced water desalination through capacitive deionization
Authors: Brotto Jaqueline O. , Padoin Natan , Rambo Carlos R. , Soares Cíntia 
Published: November 2018

Abstract
This work reports the preparation of rattan-derived carbon electrodes and their application in capacitive deionization technology for desalination. Desalination tests were performed with different concentrations of simulated seawater in a continuous mode with gravity as the driving force and applied voltages of 0.8 and 1.2 V. Electrosorption kinetics were performed to verify desalination of the saline solutions over time. Scanning electron microscopy revealed that the microstructure of the biomorphic carbon is composed of porous microchannels with diameters of around 300 mm, which allowed both fluid flow and ion retention. The kinetics of the electrosorption presented excellent results concerning desalination of highly concentrated solutions using low voltages.
Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration
Authors: Solanki Aum , Smalling Rudy , Parola Abraham H. , Nathan Ilana , Kasher Roni , Pathak Yashwant , Sutariya Vijaykumar 
Published: November 2018

Background:
Humanin is a novel neuronal peptide that has displayed potential in the treatment
of Alzheimer’s Disease through the suppression of inflammatory IL-6 cytokine receptors. Such
receptors are found throughout the body, including the eye, suggesting its other potential applications.
Age-related Macular Degeneration (AMD) is the leading cause of blindness in the developing world.
There is no cure for this disease, and current treatments have several negative side effects associated
with them, making finding other treatment options desirable.

Objective:
In this study, the potential applications in treating AMD for a more potent humanin derivative,
AGA-HNG, were studied.

Methods:
AGA-HNG was synthesized and encapsulated in chitosan Nanoparticles (NPs), which were
then characterized for their size, Encapsulation Efficiency (EE), and drug release. Their ability to suppress
VEGF secretion and protect against oxidative apoptosis was studied in vitro using ARPE-19 cells.
The chitosan NPs exhibited similar anti-VEGF properties and oxidative protection as the free protein
while exhibiting superior pharmaceutical characteristics including biocompatibility and drug release.

Results:
Drug-loaded NPs exhibited a radius of 346nm with desirable pharmacokinetic properties including
a stable surface charge (19.5 ± 3.7 mV) and steady drug release capacity. AGA-HNG showed
great promise in mediating apoptosis in hypoxic cells. They were also able to significantly reduce
VEGF expression in vitro with reduced cellular toxicity compared to the free drug.

Conclusion:
The ability of this drug delivery system to reduce retinal apoptosis with desirable pharmacokinetic
and biocompatible properties makes this a promising therapeutic option for AMD.
Asymptomatic Carriers of Presenilin-1 E318G Variant Show no Cerebrospinal Fluid Biochemical Signs Suggestive of Alzheimer’s disease in a Family with Late-onset Dementia
Authors: Artuso Vladimiro , Benussi Luisa , Ghidoni Roberta , Moradi-Bachiller Soraya , Fusco Federica , Curtolo Stefano , Roiter Ignazio , Forloni Gianluigi , Albani Diego 
Published: November 2018

Background:
Presenilin-1 (PSEN-1) is a component of the γ-secretase complex involved in
β-amyloid Precursor Protein (AβPP) processing. Usually, Alzheimer’s disease (AD)-linked mutations in
the PSEN-1 gene lead to the early onset and increase the production of the aggregation-prone peptide
Aβ42. However, the PSEN-1 E318G variant has an unclear pathogenic role and is recently reported as a
genetic risk factor for AD. In particular, E318G variant presence correlated with increased cerebrospinal
fluid (CSF) levels of Total Tau (t-tau) and Phosphorylated Tau (p-tau).

Objective:
We describe a large Italian family, which we followed from January 2003 to January 2018,
with the late-onset AD and the E318G variant, with the aim of assessing E318G-associated CSF or
plasma biochemical changes in biomarkers of dementia.

Method: CSF Aβ42, t-tau and p-tau, plasma Aβ42 and Aβ40 were assessed by ELISA tests, while CSF
amyloid peptides profile was investigated by mass spectrometry.

Results:

We did not find any changes in CSF biochemical markers (Aβ42, t-tau, p-tau and amyloid peptides)
of asymptomatic E318G carriers in 2010 and 2012, but plasma Aβ40 was increased at the same
times. From 2003 to 2018, no asymptomatic E318G carrier developed AD.

Conclusion:

Our follow-up of this family may help elucidate E318G’s role in AD and globally points to
a null effect of this variant.
Dental Implant Rehabilitation in Patients Suffering from Mucocutaneous Diseases: A Systematic Review and Meta-Analysis
Authors: Zarean Parichehr , Zarean Paridokht , Kanounisabet Negar , Moghareabed Ahmad , Rismanchian Mansour , Yadegarfar Ghasem 
Published: November 2018

Objective:Dental implantations are widely used for oral rehabilitation of edentulous patients. Despite high success rate, there are some risk factors that have been associated with failures. Oral mucocutaneous diseases are one of these risk factors for implant insertion due to the immunosuppressive therapy.There are limited studies that have dealt with the subject of dental implantology in oral mucosal disorders mainly with patients with oral lichenplanus, pemphigoid, pemphigus vulgaris, and systemic lupus erythematosus. In order to assess the result of implantations in such patients, we have reviewed the studies.Materials and Methods:We searched PubMed, Science Direct, and Cochrane databases for articles published from Jan 2000 to Dec 2017, using key search word “dental implants”, “oral lichen planus”, “pemphigoid”, “pemphigus vulgaris” and ”systemic lupus erythematosus”.Results:The random effects analysis result shows overall failure rates of 22% in patients with oral lichen planus. A systematic review revealed some failures that are not definitely related to these diseases.Conclusion:Due to the lack of adequate studies, a meta-analysis was only possible for oral lichen planus. Presently, there is no definite guideline regarding the placement of implant in patients suffering from mucocutaneous diseases; nevertheless, we should always consider that these patients are specific cases and need more attention in the first step of treatment and follow-ups. So there is a need to further clinical studies in order to evaluate more risk factors accurately and make a definitive conclusion.
Assessing Treatment Outcomes of a Graduate Orthodontic Program
Authors: Pariskou Anastasia , Athanasiou Athanasios E. 
Published: November 2018

Objectives:
To assess treatment outcomes of a graduate orthodontic program during two different periods.

Materials and Methods:
Consecutive orthodontic patients’ files were selected from the archives of the Graduate Orthodontic Program, Aristotle University of Thessaloniki, Greece. Following the application of certain inclusion criteria, the final sample consisted of 109 patients. The sample was allocated into two groups depending on the time of treatment [Group A: 1998-2003, (n=60); Group B: 2004-2009 (n=49)]. The first period started a few years after the inception of the program and the second 10 years later. All pre- and post-treatment dental casts were blindly assessed by one investigator using the Peer Assessment Rating (PAR) and the Index of Complexity, Outcome and Need (ICON). Statistical analysis included Student’s t-test, Mann-Whitney U test, Pearson Chi-Square test and Spearman correlation coefficient. The level of significance was set at p < 0.05.

Results:
In Group A, the mean PAR index changed from 28.6 before treatment to 5.5 after treatment and the mean ICON index changed from 71.9 to 23.5. In Group B, the mean PAR index changed from 23.6 before treatment to 4 after treatment and the mean ICON index changed from 62.8 to 19.8. The mean PAR score reduction was 78.4% for the 1st group and 81.4% for the 2nd group, respectively. Ninety percent of the cases of Group A and 89.8% of the cases of Group B had a post-treatment ICON score < 31. The severity of the initial malocclusion was found to be positively correlated with the treatment occlusal outcome. Out of the 109 cases, 68 were considered as substantially or greatly improved, 29 moderately improved, 8 showed minimal improvement and 4 cases were considered as not improved or worse. The mean PAR percentage improvement and the ICON score at the end of treatment were not correlated to the presence or absence of tooth extractions in the treatment plan. There was no correlation between the treatment outcome and the number of graduate residents involved in the therapy. The treatment outcomes were not correlated to the gender or age of patients.

Conclusion:
Patients treated by graduate orthodontic residents during 1998-2009 demonstrated significant improvement of their occlusion and the quality of the treatment remained constant throughout the years. The outcome of orthodontic treatment was not correlated to the gender and the age of patients, the number of postgraduate students performing the treatment, and the presence of tooth extractions in the treatment plan.
Analysis of the Correlation between Morphology and Kinematics of Anteriorly Displaced TMJ Discs Using Cine-MRI and ARCUSdigma Systems
Authors: Zhang Songmei , Zhang Zhiguang , Yu Weiqiang , Ren Yanfang , Ye Dongxia , Wang Linchuan , Qiu Jing 
Published: November 2018

Background:
Studies of mandibular movement trajectories have provided a good understanding of the motion of the condyle but little information on the geometric relationships of the disc because they have not related the movements to anatomic structures.

Objective:
This study investigated the morphology and kinematic characteristics of the Temporomandibular Joint (TMJ) using Cine-MRI and ARCUSdigma systems.

Methods:
For this study population, preliminary clinical diagnoses were asymptomatic in 15 cases, unilateral anterior disc displacement with reduction (ADDWR) in 17 cases, and unilateral Anterior Disc Displacement Without Reduction (ADDWoR) in 14 cases. Patients were investigated with Cine-MRI and ARCUSdigma systems during physiological opening and closing of the mouth.

Results:
In these groups, there were 13 healthy subjects, 19 patients with unilateral ADDWR and 14 patients with unilateral ADDWoR classified by Cine-MRI. (1) To assess morphology by MRI, disc deformities were evaluated as follows: biplanar, rounded, thickening in the posterior band, lengthened and folded. (2) The opening trajectory for healthy subjects was close to the closing trajectory. Conversely, the incisal and condylar trajectories during opening and closing were obviously bounced, deviated or shortened in the ADDWR and ADDWoR groups. The pathway of the kinematic axis was not parallel, and the condylar trajectory had an inflexion. (3) The mean values of the incisal and condylar paths of the ADDWoR group were significantly different from those in the healthy group (P<0.05), whereas there were no significant differences between the ADDWR and the healthy group (P>0.05).

Conclusion:
This study combined analysis of the condylar pathways and disc-condylar relationship to provide good visualization of morphology and kinematics during jaw movement. This process helps improve our understanding of the complexity of disk-condylar movements in subjects with TMJ internal derangement and may also contribute to our knowledge of the etiology of TMJ internal derangement.
Bond to Zirconia Ceramic: Evaluation of Different Primers and a Universal Adhesive
Authors: Ferreira da Silva Diego Fabris , Lopes Raquel de Oliveira , Caetano de Souza Niélli , Marcondes Maurem Leitão , Danesi Patrícia , Spohr Ana Maria 
Published: November 2018

Objective:
The aim of the study was to evaluate the effect of a universal adhesive and different primers on the bond strength to zirconia ceramic.

Materials and Methods:
Seventy-five zirconia ceramic samples were obtained and divided into five groups (n=15): G1–Scothbond Universal (SBU); G2 – silane + SBU; G3 - Signum Zirconia Bond; G4 - Z-Prime Plus; G5 - MZ Primer. A cone of composite resin was built. The specimens were stored in 100% relative humidity with distilled water at 37°C for 48 h and then submitted to a tensile bond strength test in a universal testing machine at a crosshead speed of 0.5 mm/min. The type of failure that occurred during the de-bonding procedure was analyzed.

Results:
The mean results of the bond strength test (MPa) followed by the same letter represent no statistical difference by ANOVA and Tukey’s post-hoc test (p<0.05): G2=27.55a (±6.99), G4=23.71a (±5.65), G1=22.64a (±5.67), G5=13.64b (±5.49), G3=7.54c (±4.75). G2 and G4 exhibited predominantly cohesive failure in the composite resin cone. G1 and G5 had predominantly mixed failures, and G3 exhibited only adhesive failures.

Conclusion:
The SBU and Z-Prime Plus provided higher bond strength to zirconia ceramic.
Cultural Tourism Behaviors: Enhancing the Influence of Tourists’ Perceptions on Local Thai Food and Culture
Authors: Prapasawasdi Urapree , Wuttisittikulkij Lunchakorn , Borompichaichartkul Chaleeda , Changkaew Laphasrada , Saadi Muhammad 
Published: November 2018

Background:Tourist behavior plays a principle role in preserving the cultural heritage and supporting the economy of the local community. Local food is a significant factor for tourists and an important cultural aspect distinguishing one country from one another. To understand tourists' food decision making, this study investigates tourists’ perceptions of local food.Methods:A mixed-method methodology used a concurrent transformative strategy. Qualitative research comprised in-depth interviews conducted with 15 local food specialists and 10 tourists; quantitative comprised survey structured questionnaires with a sample of 400 tourists travelling in Chiangmai, Thailand.Findings:The result revealed that tourists’ perceptions comprising attitude, subject norm, perceived value and expectation factors positively affected the perception toward local food information. Regression analysis suggested that the four variables contributed 53.4% to the variation of local food. By employing the standardized coefficients as mentioned, the linear regression model was Y = 0.424A-0.201S+0.428E+0.234P.Conclusion:Four factors affected tourists’ perceptions towards local food as follows: (1) expectation towards local food informationviamedia, (2) attitude of tourists towards local food, (3) perceived value of local food with the benefit, belief and nutrition of local food, and (4) subject norm towards local food; local food experts influence to tourists. All the factors lead tourists to perceive in local food and culture.
The Common Ancestor of Deinococcus Species was Rod-Shaped
Authors: Morita Yusuke , Nishida Hiromi 
Published: November 2018

Background:The genusDeinococcusconsists of species in rod-shape (Bacilli) and spherical shape (Cocci).Objective:In this study, we aimed to determine whether the common ancestor ofDeinococcusspecies was rod-shaped or spherical.Methods:We compared the homologs of the proteins related to the rod-shape in bacteria (MreB, MreC, MreD, MrdA, RodA, and RodZ) in variousDeinococcusspecies andThermus thermophilus.Results:The phylogenetic trees based on each protein and the homologs reflected the evolutionary relationships of the species, indicating that the Horizontal transfer of the genes did not occur during theDeinococcusevolution.Conclusion:The ancestor of the genusDeinococcuswas rod-shaped, and the spherical forms appeared when the rod-shaped formation system was lost during evolution and diversification within the genus.
40 jaar "Lutje P.J.G.", een lutje geschiedenis
Authors: Goudsmit W. 
Published: November 2018

Dit jaar bestaat het Groningse Lutje P.J.G. ofwel het kleine Psychiatrisch Juridisch Gezelschap 40 jaar. Het lijkt zinvol om bij deze gelegenheid kort op de geschiedenis van het 'Lutje', zoals het Lutje P.J.G. wordt genoemd, in te gaan. https://doi.org/10.21827/5a6b08f5bfdfb
Korelasi Stress dan Kualitas Hidup Pasien Hipertensi
Authors: Gultom Agustina Boru , Siregar Abdul Hanif , Yahya Syarif Zen 
Published: November 2018

AbstrakHipertensi merupakan masalah yang sering dialami masyarakat diseluruh belahan dunia. Setengah kematian akibat penyakit jantung, penyebabnya adalah hipertensi di seluruh dunia, dimana Indonesia mengalami peningkatan kasus hipertensi yang bermakna. Kualitas hidup pasien hipertensi dapat mengalami penurunan dalam beberapa aspeknya dibanding dengan pasien yang tekanan darah normal dan tanpa meminum obat antihipertensi. Disisi lain, pasien hipertensi dan terapi yang sama dapat menunjukkan gambaran kualitas hidup berbeda dikarenakan stress yang dialami seseorang berbeda-beda. Tujuan penelitian ini adalah untuk menganalisis hubungan stress dengan kualitas hidup pada pasien hipertensi di Wilayah Kerja Puskesmas Muliorejo Kabupaten Deli Serdang.. Jenis penelitian kuantitatif dengan desain penelitian korelasi, dimana sampel sebanyak 53 responden dan tehnik pengambilan sampel consecutive sampling. Hasil penelitian didapatkan bahwa rerata nilai skor stress 20,5472, skor kualitas hidup domain fisik 52,2453, skor kualitas hidup domain psikologis 57,0943, skor kualitas hidup domain sosial 52,4151, skor kualitas hidup domain lingkungan 54,1132 dan berdasarkan uji korelasi spearman’s rho menunjukkan hubungan stress dengan kualitas hidup domain fisik dengan nilai p 0,003, hubugan stress dengan kualitas hidup domain psikologis nilai p 0,001, hubungan stress dengan kualitas hidup domain sosial dengan nilai p 0,028, dan hubungan stress dengan kualitas hidup domain lingkungan dengan nilai p 0,054. Disarankan agar dapat meningkatkan kualitas hidup pada pasien hipertensi terkhusus pada domain fisik, psikologis dan sosial dengan berbagai upaya dalam pengendalian stress sehari-hari.Kata Kunci : Stress, Kualitas Hidup. Hipertensi
ANALISIS RESPON MUZAKKI TERHADAP RENCANA PEMBENTUKAN UNIT PENGUMPUL ZAKAT (STUDI PADA UNIVERSITAS LANCANG KUNING)
Authors: Waldelmi Idel 
Published: November 2018

<p><em>This research is in background, zakat that can encourage capital investment and cooperation in industry and commerce where the pushing factor is psychological motive and economic motive and the purpose of this research to know and analyze the muzakki response to UPZ formation in University of Lancang Kuning and what can be done By UPZ managers in collecting zakat. Data analysis method used in this research is descriptive analysis method. The results of to muzakki response to zakat collection unit (Upz) with score score score 4.08 in high category. Of the seven items in question there are three items that are still in the category below average ie the clarity of the office pelayann zakat, uni way in collecting zakat and zakat collection system work. The obstacles faced by managers and officers in carrying out the mandate entrusted to the officers of the Upz limited ability, lack of experience and time socialize and officers who time is limited.</em></p><p> </p><p>Penelitian ini di latarbelakangi, zakat yang dapat mendorong investasi modal dan kerjasama dalam industry dan perdagangan dimana factor yang mendorong tersebut yakni motif psikologis dan motif ekonomi dan tujuan dari penelitian ini mengetahui dan menganalisis respon muzakki terhadap pembentukkan UPZ di lingkungan Universitas lancang Kuning serta apa bisa dilakukan oleh pengelola UPZ dalam mengumpulkan zakat. Metode analisis data yang digunakan dalam penelitian ini adalah dengan metode analisis deskriptif. Hasil penelitian tehadap respon muzakki terhadap unit pengumpul zakat (Upz) dengan nilai skor jawaban 4,08 dalam kategori tinggi. Dari tujuh item yang ditanyakan terdapat tiga item yang masih dalam kategori dibawah rata rata yakni kejelasan kantor pelayann zakat, cara uni dalam mengumpulkna zakat dan sistem kerja pengumpulan zakat. Hambatan yang dihadapi pengelola dan petugas dalam menjalankan amanah yang dipercayakan ke petugas Upz yakni kemampuan yang terbatas, minimnya pengalaman dan waktu mensosialisasikan serta petugas yang waktunya terbatas.</p>
PELAKSANAAN PEMUNGUTAN PAJAK AIR TANAH KECAMATAN TAMPAN KOTA PEKANBARU
Authors: Rini Silfia 
Published: November 2018

<p><em>The purpose of this research is to know the implementation of ground water taxation in the Kecamatan Tampan Kota Pekanbaru. This research uses interview method and questionnaire. The author conducted an interview to the Head of Regional Revenue Service (Kadispenda) Pekanbaru City. For the questionnaire the author distributed as many as 20 respondents. This research indicates the existence of public ignorance of the enactment of local government regulation (Perda) Pekanbaru City No.112 of 2011 on Ground Water Tax (PAT). PAT collection in particular hotels located in Kecamatan Tampan Pekanbaru City there are still not paid PAT and also there are businessmen who have not register their business to Dispenda Pekanbaru City. Because they thought it was not necessary to pay for the PAT. PAT collection based on city regulation Pekanbaru number 12 of 2011 on PAT is one way to increase local revenue (PAD).</em></p><p><em><br /></em></p><p class="Default">Tujuan dalam penelitian adalah untuk mengetahui pelaksanaan pungutan pajak air tanah di kecamatan tampan Kota Pekanbaru. Penelitian ini menggunanakan metode wawacara dan kuesioner. Penulis melakukan wawancara kepada Kepala Dinas Pendapatan Daerah (Kadispenda) Kota Pekanbaru. Untuk kuesioner penulis membagikan sebanyak 20 responden. Penelitian ini menunjukkan adanya ketidaktahuan masyarakat terhadap telah diberlakukannya peraturan pemerintah daerah (Perda) Kota Pekanbaru no.12 tahun 2011 tentang Pajak Air Tanah (PAT). Pemungutan PAT khususnya Hotel yang berada di kecamatan Tampan Kota Pekanbaru masih ada yang belum membayarkan PAT dan juga para usahawanada yang belum mendaftarkan usahanya ke DispendaKota Pekanbaru. Karena mereka mengira tidak perlu untuk membayar PAT terebut.Pemungutan PAT berdasarkan peraturan daerah kota pekanbaru nomor 12 tahun 2011 tentang PAT merupakan salah satu cara untuk meningkatkan pendapatan asli daerah (PAD).</p><p><em><br /></em></p>
Características físico-químicas e toxicológicas do agrotóxico Espinosade
Authors: Bizon Larissa , Gonçalves Priscila Boleta , De Campos Marcelo da Roz 
Published: November 2018

Espinosade é um agrotóxico utilizado no controle de pragas. Sua composição é a mistura de dois ingredientes em uma proporção típica de 85:15, sendo eles a espinosina A e espinosina D, respectivamente. Apresenta solubilidade moderada, coeficiente de partição octanol-água (Kow) e coeficiente de adsorção (Koc) altos e baixa constante de Henry. O valor adotado pela ANVISA, 2016, de dose de referência do composto é de 0,02 mg/kg/dia, sendo possível derivar um padrão de potabilidade de 0,09 mg/L. Os dados de toxicidade para biota aquática indicam maior toxicidade para o crustáceo Daphnia magna com CENO de 0,617 μg/L. Com tais valores foi possível encontrar o critério de proteção da vida aquática cujo valor obtido é 61,7 ng/L para a água doce. Como não foram encontradas ocorrências da substância no ambiente, não foi possível avaliar o seu risco para a vida aquática; porém seu uso é permitido no Brasil e União Europeia e mais estudos devem ser realizados sobre o Espinosade e seus efeitos.
Impactos do manganês na saúde pública
Authors: Freitas Van Opstal Nascimento Tatiana , Gaspar Gonzalez Fabiana 
Published: November 2018

O manganês é um metal pesado utilizado na fabricação de objetos comuns à população e em indústrias. Seus sintomas são inespecíficos, o que dificulta que uma possível intoxicação seja perceptível. Diante disso, pretende-se elucidar as principais consequências da intoxicação por este metal, bem como orientar e conscientizar a população e trabalhadores a respeito dos riscos e prevenção. Visto que não há tratamento estabelecido para danos neurológicos permanentes causados por tal intoxicação, porém alguns dos sintomas podem ser controlados.