bluuebunny/crossref_metadata_2025_split huggingface dataset:
Staging and managing patients with acromegaly in clinical practice: baseline data from the SAGIT® validation study
Authors: Giustina Andrea , Bronstein Marcello D. , Chanson Philippe , Petersenn Stephan , Casanueva Felipe F. , Sert Caroline , Houchard Aude , Melmed Shlomo 
Published: July 2019

Abstract
Purpose
The SAGIT® instrument, designed to assist clinicians to stage acromegaly, assess treatment response and adapt patient management, was well received by endocrinologists in a pilot study. We report an interim analysis of baseline data from the validation phase.

Methods
The SAGIT® validation study (ClinicalTrials.gov NCT02539927) is an international, non-interventional study. Data collection included: demographic/disease characteristics; medical/surgical histories; concomitant acromegaly treatments; investigators’ subjective evaluation of disease-control status (clinical global evaluation of disease control [CGE-DC]; controlled/not controlled/yet to be clarified) and clinical disease activity (active/not active); growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels; investigators’ therapeutic decision.

Results
Of 228 patients enrolled, investigators considered disease to be controlled in 110 (48.2%), not controlled in 105 (46.1%), and yet to be clarified in 13 (5.7%) according to CGE-DC. Thirty-three patients were treatment-naïve (not controlled, n = 31; yet to be clarified, n = 2). Investigators considered 48.2% patients in the controlled and 95.2% in the not-controlled groups to have clinically active disease. In the controlled group, 29.7% of patients did not exhibit hormonal control (GH ≤ 2.5 µg/L; normalized IGF-1) and 47.3% did not have rigorous hormonal control (GH < 1.0 µg/L; normalized IGF-1) by contemporary consensus. Current acromegaly treatment was continued with no change for 91.8% of patients in the controlled and 40.0% in the not-controlled groups.

Conclusions
These data highlight discrepancies between investigator-evaluated disease-control status, disease activity, hormonal control, and treatment decisions in acromegaly. Once validated, the SAGIT® instrument may assist clinicians in making active management decisions for patients with acromegaly.
Influence of negative emotions on residents’ learning of scientific information: an experimental study
Authors: Kremer Telma , Mamede Silvia , Van den Broek Walter W. , Schmidt Henk G. , Nunes Maria do P. T. , Martins Milton A. 
Published: July 2019

Introduction Medical training is consistently described as emotionally challenging. Students commonly encounter situations that are likely to trigger emotional reactions, but the influence of emotional reactions to these situations on learning is unclear. This experiment examined the effects of negative emotions on medical residents’ learning of scientific information.
Methods Sixty first-year internal medicine residents (i.e. physicians in training to become specialists) at the São Paulo University Medical School were randomly assigned to watching a video clip either presenting an emotional (experimental group) or a neutral (control group) version of the same situation. Subsequently, all residents studied the same scientific text. Main outcome measurements were learning processes (inferred through study time and cognitive engagement) and outcomes (recall accuracy). Data were analyzed using chi-square and independent t‑tests.
Results The experimental group spent significantly less time (p < 0.001) studying the text and performed significantly worse on the free recall test (p < 0.001) than the control group.
Discussion Negative emotions decreased time invested in a learning task and the amount of knowledge gained from it, possibly because they automatically activated avoidance attitudes or captured part of the residents’ cognitive resources, hindering processing of the learning material. Future studies should further explore the underlying mechanisms of this effect and how it can be diminished.
Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy
Authors: Jiang Zhenqi , Yuan Bo , Qiu Nianxiang , Wang Yinjie , Sun Li , Wei Zhenni , Li Yanyin , Zheng Jianjun , Jin Yinhua , Li Yong , Du Shiyu , Li Juan , Wu Aiguo 
Published: July 2019

Abstract
Zeolitic imidazolate frameworks (ZIFs) as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy. However, the exploration of ZIFs in biomedicine still encounters many issues, such as inconvenient surface modification, fast drug release during blood circulation, undesired damage to major organs, and severe in vivo toxicity. To address the above issues, we developed an Mn-ZIF-90 nanosystem functionalized with an originally designed active-targeting and pH-responsive magnetic resonance imaging (MRI) Y1 receptor ligand [Asn28, Pro30, Trp32]-NPY (25–36) for imaging-guided tumor therapy. After Y1 receptor ligand modification, the Mn-ZIF-90 nanosystem exhibited high drug loading, better blood circulation stability, and dual breast cancer cell membrane and mitochondria targetability, further favoring specific microenvironment-triggered tumor therapy. Meanwhile, this nanosystem showed promising T1-weighted magnetic resonance imaging contrast in vivo in the tumor sites. Especially, this nanosystem with fast clean-up had almost no obvious toxicity and no damage occurred to the major organs in mice. Therefore, this nanosystem shows potential for use in imaging-guided tumor therapy.
Mixed emotion experiences for self or another person in adolescence
Authors: Burkitt Esther , Watling Dawn , Cocks Francesca 
Published: July 2019

ABSTRACTIntroductionThis study examined types of reported simultaneous mixed emotion experiences for the first time in adolescence for high and low intensity emotion pairs using an Analogue Emotion Scale which affords the graphing of two opposite valence emotions over time on the same graph.MethodsIn a cross sectional design, 163 participants based in schools across the UK formed two age groups representing early and mid‐adolescence (12 years, 5 months‐16 years, 9 months vs. 16 years, 10 months‐18 years, 8 months) across two conditions considering either their own (n = 83) or another child's (n = 80) emotional experience divided equally for high (n = 80) or low (n = 83) intensity mixed emotion pairs presented in vignettes about themselves or another person. They were seen individually and completed an emotion presence interview and an Analogue Emotion Scale about the emotions experienced in the condition appropriate vignette.ResultsParticipants reported mixed emotions both sequentially and simultaneously. In particular we found that children showed that others experience emotions in a more sequential manner, while they themselves would experience more emotions in a highly simultaneous way. Emotion experience was different depending on the emotion pair and age group.ConclusionsAdolescents’ subjective mixed emotion experiences vary by intensity and patterns of simultaneity over time. Findings are discussed in relation to an evaluative space model of mixed emotion and applications of the AES with adolescent populations.
Evaluating Perceived Emergency Preparedness and Household Preparedness Behaviors: Results from a CASPER Survey in Fairfax, Virginia
Authors: Ferguson Rennie W. , Kiernan Shawn , Spannhake Ernst W. , Schwartz Benjamin 
Published: July 2019

ABSTRACTObjectives:Using data collected from a Community Assessment for Public Health Emergency Response (CASPER) conducted in Fairfax Health District, Virginia, in 2016, we sought to assess the relationship between household-level perceived preparedness and self-reported preparedness behaviors.Methods:Weighted population estimates and 95% confidence intervals were reported, and Pearson’s chi-squared test was used to investigate differences by group.Results:Examining responses to how prepared respondents felt their household was to handle a large-scale emergency or disaster, an estimated 7.4% of respondents (95% CI: 4.3–12.3) reported that their household was “completely prepared,” 37.3% (95% CI: 31.4–43.7) were “moderately prepared,” 38.2% (95% CI: 31.6–45.2) were “somewhat prepared,” and 14.4% (95% CI: 10.2–20.0) were “unprepared.” A greater proportion of respondents who said that their household was “completely” or “moderately” prepared for an emergency reported engaging in several behaviors related to preparedness. However, for several preparedness behaviors, there were gaps between perceived preparedness and self-reported readiness.Conclusions:Community assessments for public health preparedness can provide valuable data about groups who may be at risk during an emergency due to a lack of planning and practice, despite feeling prepared to handle a large-scale emergency or disaster.
Circulation and Energy Theorem Preserving Stochastic Fluids
Authors: Drivas Theodore D. , Holm Darryl D. 
Published: July 2019

AbstractSmooth solutions of the incompressible Euler equations are characterized by the property that circulation around material loops is conserved. This is the Kelvin theorem. Likewise, smooth solutions of Navier–Stokes are characterized by a generalized Kelvin's theorem, introduced by Constantin–Iyer (2008). In this note, we introduce a class of stochastic fluid equations, whose smooth solutions are characterized by natural extensions of the Kelvin theorems of their deterministic counterparts, which hold along certain noisy flows. These equations are called thestochastic Euler–Poincaréandstochastic Navier–Stokes–Poincaréequations respectively. The stochastic Euler–Poincaré equations were previously derived from a stochastic variational principle by Holm (2015), which we briefly review. Solutions of these equations do not obey pathwise energy conservation/dissipation in general. In contrast, we also discuss a class of stochastic fluid models, solutions of which possess energy theorems but do not, in general, preserve circulation theorems.
Food composition of whiting Merlangius merlangus, captured around the sea-cage fish farms in Ordu, south-eastern Black Sea
Authors: Şensurat-Genç Tuğçe , Akyol Okan , Özgül Aytaç , Özden Uğur 
Published: July 2019

AbstractThe food composition of whiting, Merlangius merlangus, caught around the sea-cage fish farms off the coast of Perşembe, was analysed and compared with the diet of whiting from a control site off the coast of Fatsa (Ordu Province, south-eastern Black Sea). A total of 815 stomach samples were collected during the study, and of these, 195 (23.9%) were empty. According to the percentage of relative importance index (IRI%), pellet food (47.8%) and Annelida (25%) were the main prey groups of whiting in the sea-cage fish farms area, while unidentified teleost (85.3%) and Engraulis encrasicolus (8.2%) were dominant in the control site. The other prey groups in both areas were Crustaceans (Mysidae, Amphipoda, Upogebia sp.), Sprattus sprattus and Gobius spp. Seasonally, pellet food was the most consumed food in all seasons, but Mysidae was the first preference of whiting around the sea-cage fish farms in spring. In the control site, unidentified teleost was the first preference in all seasons, except winter, where E. encrasicolus was the first choice, followed by crustaceans and S. sprattus in winter. Bray–Curtis analysis shows that seasonally, there is no significant difference in the sea-cage fish farms, while there is significant difference in the control site, and two-dimensional nMDS of IRI% revealed a clear separation between both sites. SIMPER analysis revealed that the most contributing factors to the differences between seasons were pellet food in the sea-cage fish farms, and E. encrasicolus in the control site.
What is taken for granted in autism research?
Authors: Friedner Michele Ilana 
Published: July 2019

Abstract
This commentary focuses on three points: the need to consider semiotic ideologies of both researchers and autistic people, questions of commensurability, and problems with “the social” as an analytical concept. It ends with a call for new research methodologies that are not deficit-based and that consider a broad range of linguistic and non-linguistic communicative practices.
Beyond autism: Challenging unexamined assumptions about social motivation in typical development
Authors: Bartsch Karen , Estes David 
Published: July 2019

Abstract
In challenging the assumption of autistic social uninterest, Jaswal & Akhtar have opened the door to scrutinizing similar unexamined assumptions embedded in other literatures, such as those on children's typically developing behaviors regarding others’ minds and morals. Extending skeptical analysis to other areas may reveal new approaches for evaluating competing claims regarding social interest in autistic individuals.
Normocentric biases taint cognitive neuroscience and intervention of autism
Authors: Mottron Laurent 
Published: July 2019

Abstract
Stepping away from a normocentric understanding of autism goes beyond questioning the supposed lack of social motivation of autistic people. It evokes subversion of the prevalence of intellectual disability even in non-verbal autism. It also challenges the perceived purposelessness of some restricted interests and repetitive behaviors, and instead interprets them as legitimate exploratory and learning-associated manifestations.
Two sources of bias affecting the evaluation of autistic communication
Authors: Li Pearl Han , Koenig Melissa 
Published: July 2019

Abstract
We support Jaswal & Akhtar's interrogation of social motivational accounts of autism and discuss two sources of bias that contribute to how others construe autistic people's communications: (1) an experience-based bias that limits our ability to discern the speaker's action as communicative and (2) a prejudice against the credibility of certain speakers that limits a listener's willingness to believe their testimony.
Social motivation in autism: Gaps and directions for measurement of a putative core construct
Authors: Keifer Cara M. , Dichter Gabriel S. , McPartland James C. , Lerner Matthew D. 
Published: July 2019

AbstractThis commentary highlights the observation that social motivation is usually an imprecisely specified construct. We suggest four social motivation conceptualizations across levels of analysis and explore where the target article situates among these. We then offer theoretical and practical guidance for operationalization and measurement of social motivation to support more comprehensive future research on this complex construct in the autism literature.
Socially interested, or socially sophisticated? On mutual social influence in autism
Authors: Forgeot d'Arc Baudouin , Soulières Isabelle 
Published: July 2019

Abstract
A lower tendency to influence and be influenced by their social environment seems almost self-evident in autism. However, a closer look at differences and similarities between autistic and non-autistic individuals suggests that some basic mechanisms involved in social influence might be intact in autism, whereas atypical responses point to differences in more sophisticated recursive social strategies, such as reputation management.
Syntactic development in early foreign language learning: Effects of L1 transfer, input, and individual factors
Authors: Hopp Holger , Steinlen Anja , Schelletter Christina , Piske Thorsten 
Published: July 2019

AbstractThis study explores parallels and differences in the comprehension ofwh-questions and relative clauses between early foreign-language (FL) learners and monolingual children. We test for (a) effects of syntactic first-language (L1) transfer, (b) the impact of input on syntactic development, and (c) the impact of individual differences on early FL syntactic development. We compare the results to findings in child second language (L2) naturalistic acquisition and adult FL acquisition. Following work on adult FL acquisition, we carried out a picture-based interpretation task with 243 child FL learners in fourth grade at different regular, partial, and high-immersion schools in Germany plus 68 monolingual English children aged 5 to 8 years as controls. The child FL learners display a strong subject-first preference but do not appear to use the L1 syntax in comprehension. Input differences across different schools affect overall accuracy, with students at high-immersion FL schools catching up to monolingual performance within 4 years of learning. Finally, phonological awareness is implicated in both early FL learning and naturalistic child L2 development. These findings suggest that early FL development resembles child L2 acquisition in speed and effects of individual factors, yet is different from adult FL acquisition due to the absence of L1 transfer effects.
THE CHANGING SIGNIFICANCE OF LATIN AMERICAN SILVER IN THE CHINESE ECONOMY, 16TH–19THCENTURIES
Authors: Von Glahn Richard 
Published: July 2019

ABSTRACTThe important role of Chinese demand for silver in stimulating worldwide silver-mining and shaping the first truly global trading system has become commonly recognised in the world history scholarship. The commercial dynamism of China during the 16th-19th centuries was integrally related to the importation of foreign silver, initially from Japan but principally from Latin America. Yet the significance of imports of Latin American silver for the Chinese economy changed substantially over these three centuries in tandem with the rhythms of China's domestic economy as well as the global trading system. This article traces these changes, including the adoption of a new standard money of account—the yuan—derived from the Spanish silver peso coin.
Technology and Learner Autonomy: An Argument in Favor of the Nexus of Formal and Informal Language Learning
Authors: Lai Chun 
Published: July 2019

AbstractThis article discusses some of the current research on technology in relation to learner autonomy, outlining major findings on the relationship between technology and learner autonomy in formal and informal learning contexts. Extant literature has discussed both teacher-initiated technology-enhanced formal learning environments and learner-constructed self-directed learning experience in informal learning contexts. Although valuable in the insights it provides into how technology aids learner autonomy, the two bodies of literature have largely been independent from each other, which may constrain our understanding.
Media and Second Dialect Acquisition
Authors: Nycz Jennifer 
Published: July 2019

AbstractThis article addresses the role that different types of media might play in second dialect acquisition. While many scholars agree that broadcast media such as television have little effect on individual speakers’ language use, research across fields (sociolinguistics, second language learning, laboratory phonology, and phonetics) suggests that high levels of engagement could facilitate dialect learning via mediated speech. I will briefly describe the mechanisms underlying acquisition of new dialect features, discuss how these mechanisms might operate when speakers are exposed to speech via specific types of media, and sketch some avenues for future research.
Alignment During Synchronous Video Versus Written Chat L2 Interactions: A Methodological Exploration
Authors: Michel Marije , Cappellini Marco 
Published: July 2019

AbstractConversational alignment (i.e., the automatic tendency of interactants to reuse each other's morphosyntactic structures and lexical choices in natural dialogue) is a well-researched phenomenon in native (Pickering & Ferreira, 2008) and to a smaller extent in second language (L2) speakers (Jackson, 2018) as confirmed by many highly controlled lab-based experimental studies investigating face-to-face oral interaction. Only a few studies have explored alignment in more naturally occurring L2 interactions (e.g., Dao, Trofimovich, & Kennedy, 2018), some of them extending the context to written computer-mediated communication (SCMC) (e.g., Michel & Smith, 2018).The current study aimed to address this gap by taking a closer look at alignment in L2 conversations mediated by two different types of SCMC (videoconference vs. text chat). We explored lexical as well as structural alignment in three target languages (Chinese, French, and German) involving interactional partners of different status (L2 peer, L1 peer, and L1 tutor).Results revealed that lexical and structural alignment are both present and observable in different SCMC contexts. From a methodological point of view, we discuss how different analyses suit the data generated by the affordances of the different SCMC contexts in the target languages and argue for a more dynamic and pervasive perspective on interaction.
Corpus Linguistics, Learner Corpora, and SLA: Employing Technology to Analyze Language Use
Authors: McEnery Tony , Brezina Vaclav , Gablasova Dana , Banerjee Jayanti 
Published: July 2019

AbstractIn this article we explore the relationship between learner corpus and second language acquisition research. We begin by considering the origins of learner corpus research, noting its roots in smaller scale studies of learner language. This development of learner corpus studies is considered in the broader context of the development of corpus linguistics. We then consider the aspirations that learner corpus researchers have had to engage with second language acquisition research and explore why, to date, the interaction between the two fields has been minimal. By exploring some of the corpus building practices of learner corpus research, and the theoretical goals of second language acquisition studies, we identify reasons for this lack of interaction and make proposals for how this situation could be fruitfully addressed.
Operable ventricular septal defect despite severe pulmonary hypertension and cyanosis!
Authors: Kothari Shyam S. , Relan Jay , Devagourou Velayoudam 
Published: July 2019

AbstractPatients with a significant left-to-right shunt at ventricular level may become inoperable at an early age due to irreversible pulmonary vascular disease. On the other hand, even suprasystemic pulmonary hypertension due to mitral stenosis remains treatable. We report a 24-year-old patient with large ventricular septal defect, severe mitral stenosis and cyanosis who improved after surgical correction of both the lesions. This emphasises the importance of additional post-capillary pulmonary hypertension in Eisenmenger syndrome.
Process Understanding of Soil BVOC Fluxes in Natural Ecosystems: A Review
Authors: Tang J. , Schurgers G. , Rinnan R. 
Published: July 2019

AbstractBiogenic volatile organic compounds (BVOCs) can be released from soils to the atmosphere through microbial decomposition of plant residues or soil organic carbon, root emission, evaporation of litter‐stored BVOCs, and other physical processes. Soils can also act as a sink of BVOCs through biotic and abiotic uptake. Currently, the source and sink capabilities of soils have not been explicitly accounted for in global BVOC estimates from the terrestrial biosphere. In this review, we summarize the current knowledge of soil BVOC processes and aim to propose a generic framework for modelling soil BVOCs based on current understanding and data availability. To achieve this target, we start by reviewing measured sources and sinks of soil BVOCs and summarize commonly reported compounds. Next, we strive to disentangle the drivers for the underlying biotic and abiotic processes. We have ranked the list of compounds, known to be emitted from soils, based on our current understanding of how each process controls emission and uptake. We then present a modelling framework to describe soil BVOC emissions. The proposed framework is an important step toward initializing modelling exercises related to soil BVOC fluxes. Finally, we also provide suggestions for measurements needed to separate individual processes, as well as explore long‐term and large‐scale patterns in soil BVOC fluxes.