bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sputum microbiomic clustering in asthma and chronic obstructive pulmonary disease reveals a Haemophilus‐predominant subgroup
Authors: Diver Sarah , Richardson Matt , Haldar Koirobi , Ghebre Michael A. , Ramsheh Mohammadali Y. , Bafadhel Mona , Desai Dhananjay , Cohen Emma Suzanne , Newbold Paul , Rapley Laura , Rugman Paul , Pavord Ian D. , May Richard D. , Barer Michael , Brightling Christopher.E. 
Published: September 2019

AbstractBackgroundAirway ecology is altered in asthma and chronic obstructive pulmonary disease (COPD). Anti‐microbial interventions might have benefit in subgroups of airway disease. Differences in sputum microbial profiles at acute exacerbation of airways disease are reflected by the γProteobacteria:Firmicutes (γP:F) ratio. We hypothesized that sputum microbiomic clusters exist in stable airways disease, which can be differentiated by the sputum γP:F ratio.MethodsSputum samples were collected from 63 subjects with severe asthma and 78 subjects with moderate‐to‐severe COPD in a prospective single centre trial. Microbial profiles were obtained through 16S rRNA gene sequencing. Topological data analysis was used to visualize the data set and cluster analysis performed at genus level. Clinical characteristics and sputum inflammatory mediators were compared across the clusters.ResultsTwo ecological clusters were identified across the combined airways disease population. The smaller cluster was predominantly COPD and was characterized by dominance of Haemophilus at genus level (n = 20), high γP:F ratio, increased H influenzae, low diversity measures and increased pro‐inflammatory mediators when compared to the larger Haemophilus‐low cluster (n = 121), in which Streptococcus demonstrated the highest relative abundance at the genus level. Similar clusters were identified within disease groups individually and the γP:F ratio consistently differentiated between clusters.ConclusionCluster analysis by airway ecology of asthma and COPD in stable state identified two subgroups differentiated according to dominance of Haemophilus. The γP:F ratio was able to distinguish the Haemophilus‐high versus Haemophilus‐low subgroups, whether the Haemophilus‐high group might benefit from treatment strategies to modulate the airway ecology warrants further investigation.
Cooking together: The IKEA effect on family vegetable intake
Authors: Radtke Theda , Liszewska Natalia , Horodyska Karolina , Boberska Monika , Schenkel Konstantin , Luszczynska Aleksandra 
Published: September 2019

ObjectiveBased on the idea of the ‘IKEA effect’, assuming that individuals like self‐created objects more than objects created by someone else, this study hypothesizes that parents’ involvement of their children in meal planning and preparation is positively related to vegetable intake, mediated via liking vegetables.DesignLongitudinal observational study with two time points (10‐month interval).MethodNine hundred and twenty‐four parent–child dyads filled out questionnaires measuring involvement, vegetable liking, vegetable intake, and further environmental and food‐related determinants of vegetable intake. On average, parents were M = 36.10 (SD = 5.43) and children (54.3% girls) M = 8.24 (SD = 1.44; range 6–11) years old. Hypotheses were tested with path analyses, accounting for intra‐dyadic associations among respective constructs (e.g., parents’ and children's liking vegetables).ResultsTwo direct effects were found: (1) parents’ involvement of their children in cooking activities impacted children's liking of vegetables and vegetable intake, and (2) liking vegetables impacted vegetable intake. The effect of involvement on vegetable intake was mediated via liking vegetables, but only for children and not for parents.ConclusionsThe findings emphasize the importance of parents’ encouragement for involving children in the preparation of healthy meals, as this improves liking of vegetables and, thereby, increases their vegetable intake.
Statement of contribution

What is already known on this subject?

Processes behind the effectiveness of shared cooking activities to increase vegetable intake are unclear.

Previous research suggests the IKEA effect as an explanation.

It assumes a higher consumption of self‐created products due to a higher liking compared to third‐party products.

What does this study add?

First test of the IKEA effect for joint cooking activities under consideration of spillover effects in families.

Affirmation of the IKEA effect was found for children, not for parents.

Interventions should focus on the involvement of children in cooking activities to improve vegetable intake.
Fluorescence in‐situ hybridisation for TP63 rearrangements in T cell lymphomas: single‐site experience of 470 patients and implications for clinical testing
Authors: Peterson Jess F , Pearce Kathryn E , Meyer Reid G , Greipp Patricia T , Knudson Ryan A , Baughn Linda B , Ketterling Rhett P , Feldman Andrew L 
Published: September 2019

AimsThe aims of this study were to review our 5‐year experience with clinical FISH testing for TP63 rearrangements using both TP63 break‐apart (BAP) and TBL1XR1/TP63 dual‐fusion (D‐FISH) probes to evaluate the frequency of TP63 rearrangements and the distribution of TBL1XR1 vs. alternate partner loci, and to assess whether both probe sets are necessary in all cases undergoing FISH testing.Methods and resultsA retrospective review of the Mayo Clinic cytogenetic database identified 470 patients evaluated by FISH testing for TP63 rearrangements in formalin‐fixed paraffin‐embedded (FFPE) tissue using both BAP and D‐FISH probes. Of these, 25 (5.3%) had TP63 rearrangements. All samples were being investigated for anaplastic large‐cell lymphoma or other T cell lymphoma subtypes. A TBL1XR1 partner was identified by D‐FISH in 12 (48%) of 25 cases. All cases positive by TBL1XR1/TP63 D‐FISH were also positive by TP63 BAP FISH.ConclusionThis is the largest series of TP63 rearrangements to date. The frequency of positive results among cases referred to a large reference laboratory for TP63 FISH testing was 5.3%. Approximately half of TP63 rearrangements have a TBL1XR1 partner. TP63 BAP FISH testing is sufficient for up‐front testing of FFPE tissue samples. However, because of the genomic proximity of the TP63 and TBL1XR1 loci, we recommend reflex TBL1XR1/TP63 D‐FISH testing in positive and equivocal cases.
The associations among illness perceptions, resilient coping, and medication adherence in young adult hypertensive black women
Authors: Spikes Telisa , Higgins Melinda , Lewis Tene’ , Dunbar Sandra B. 
Published: September 2019

AbstractHypertension, a modifiable risk factor of cardiovascular disease, is largely responsible for the disproportionate morbidity and mortality in black women. Black women 20 years of age and older have a higher prevalence of HTN compared to white women (44% vs 28%). Poor adherence and non‐adherence to hypertensive medications have been strongly indicated as a primary contributor to the early onset of disparity in cardiovascular disease morbidity and mortality experienced by black people. The purpose of this study was to examine medication adherence in black women relative to sociodemographic, clinical, cultural context, psychosocial, cognitive, and behavioral factors. This was a prospective, descriptive cross‐sectional study of N = 85, hypertensive black women, with mean age of 39 ± 5.4 years, 18‐45 years of age. Variables and measures included: sociodemographic characteristics, clinical, adverse social stressors, psychosocial, cognitive‐behavioral factors, and medication adherence. Descriptive statistics, correlations, multivariate logistic regressions, and moderation analysis were tested. 81.2% (n = 69) of the sample was categorized as non‐adherent. SBP was the only clinical covariate associated with HTN medication adherence. HTN illness perceptions, composite score, resilient coping, depressive symptoms, exposure to lifetime gender, and racial stressors, were not associated with HTN medication adherence. Using multivariate logistic regression, decreased SBP and lower scores on the “Consequence” dimension of the HTN illness perception scale were associated with medication adherence (χ2 = 10.53,P = .001). Adherence was associated with both the “Consequence” and “Identity” dimensions of the HTN illness perception scale indicating the need and importance for clinicians to have open and honest communication regarding HTN and its treatment in facilitating adherence.
Optical fluorescence imaging with shortwave infrared light emitter nanomaterials for in vivo cell tracking in regenerative medicine
Authors: Fath‐Bayati Leyla , Vasei Mohammad , Sharif‐Paghaleh Ehsan 
Published: September 2019

AbstractIn vivo tracking and monitoring of adoptive cell transfer has a distinct importance in cell‐based therapy. There are many imaging modalities for in vivo monitoring of biodistribution, viability and effectiveness of transferred cells. Some of these procedures are not applicable in the human body because of low sensitivity and high possibility of tissue damages. Shortwave infrared region (SWIR) imaging is a relatively new technique by which deep biological tissues can be potentially visualized with high resolution at cellular level. Indeed, scanning of the electromagnetic spectrum (beyond 1000 nm) of SWIR has a great potential to increase sensitivity and resolution of in vivo imaging for various human tissues. In this review, molecular imaging modalities used for monitoring of biodistribution and fate of administered cells with focusing on the application of non‐invasive optical imaging at shortwave infrared region are discussed in detail.
The clinical and microbiological features and outcomes of fungal keratitis over 9 years in Sydney, Australia
Authors: Watson Stephanie L. , Cabrera‐Aguas Maria , Keay Lisa , Khoo Pauline , McCall Dominic , Lahra Monica M. 
Published: September 2019

SummaryTo describe the clinical features, management and outcomes in patients with fungal keratitis at the Sydney Eye Hospital, Australia, over a 9‐year period to guide appropriate initial therapy. A retrospective case review was conducted. Patients diagnosed with fungal keratitis from 1 January 2009 to 31 December 2017 were identified from hospital coding and pathology databases. Data were extracted from the medical records. A total of 55 episodes from 51 patients were included. Mean age was 60 ± 20 years (range: 19‐91 years), and 33 were male. The fungal species was not identified in two patients. Predisposing factors included ocular surface disease in 17 eyes (32%); corneal disease, 15 (28%); corneal trauma, 12 (23%); and contact lens wear, 13 (24.5%). Fusarium spp. (15, 27%) and Candida parapsilosis (10, 18%) were the most common isolates. The median visual acuity at presentation was 1.3 logMAR (range: 0 to 3) and after treatment 0.7 logMAR (range: −0.02 to 3) (P = .008). Despite medical therapy, most commonly with natamycin and topical and oral voriconazole, surgical intervention was required in 21 eyes (40%); including antifungal injections in 9 (16%); corneal transplantation, 16 (30%); evisceration, 2 (4%); and enucleation, 1 (2%). A poor visual outcome was recorded in 27 of 43 (63%) patients. Fungal keratitis remains a cause of significant ocular morbidity; the majority of patients face a poor outcome despite intense medical and at times surgical treatment. In our setting, fungal keratitis was more commonly associated with corneal or ocular surface disease.
Successful treatment of post‐transplant CMV meningoencephalitis with third‐party CMV virus‐specific T cells: Lessons learned
Authors: Alonso Laura , Rudilla Francesc , Gimeno Ramón , Codinach Margarita , Blanco Margarita , Querol Sergio , Diaz de Heredia Cristina 
Published: September 2019

AbstractCytomegalovirus encephalitis is a challenging life‐threatening complication following hematopoietic stem cell transplantation for which medical treatment is usually ineffective or toxic. However, in recent years, adoptive T‐cell therapy has been reported to provide a significant chance of cure for patients with viral infections. Herein, two cases of pediatric patients successfully treated with third‐party donor‐derived virus‐specific T cells for CMV meningoencephalitis are reported.
Discontinuance of tebuconazole in the field restores sensitivity of Monilinia fructicola in stone fruit orchards
Authors: Pereira W. V. , Morales R. G. F. , Bauer A. I. G. , Kudlawiec K. , May‐De‐Mio L. L. 
Published: September 2019

Demethylation inhibitor (DMI) fungicides are used to control brown rot in stone fruit worldwide. However, their specific mode of action can select resistant isolates of Monilinia fructicola. Monilinia fructicola resistant to DMI fungicides are associated with a fitness cost in the absence of selective pressure, indicating that the sensitive population can be re‐established when discontinuing the fungicide in the field. This work aimed to build up the sensitive population of M. fructicola after discontinuing the use of tebuconazole for successive crop seasons. The sensitivity of M. fructicola to tebuconazole was assessed in four commercial peach orchards in Paraná and São Paulo States from 2012/13 to 2015/16. Different fungicide programmes were used and DMI fungicides were discontinued from 2013/14. The sensitivity of M. fructicola to tebuconazole was assessed by a mycelial growth assay in vitro and by determining the frequency of the G461S mutation in the MfCYP51 gene. The isolates from Paraná had high sensitivity to the fungicide across all seasons and the frequency of the G461S mutation remained below 5%. The isolates from São Paulo were highly resistant in the 2012/13 season; however, there was a gradual decline until 2015/16. In addition, the G461S mutation frequency in Sao Paulo State was about 80% in the 2012/13 season, but reduced until it was completely undetectable in 2015/16. These results provide evidence that resistance can be managed in orchards with high selective pressure to tebuconazole after discontinuing the use of the fungicide for at least 3 years.
Maternal smoking during pregnancy and offspring utilisation of health care services: A population‐based cohort study
Authors: Narvestad Helene , Vestergaard Claus Høstrup , Rytter Dorte , Bech Bodil Hammer 
Published: September 2019

AbstractBackgroundMaternal smoking during pregnancy (MSDP) has been associated with a wide range of adverse effects on offspring health, such as low birthweight, behavioural disorders, and asthma. The number of women that smoke during pregnancy in Denmark is still high, making it relevant to study the long‐term health outcomes in offspring exposed to maternal smoking in utero.ObjectiveWe investigated whether exposure to MSDP is associated with more frequent use of health care services during the first 10 years of life.MethodsThis population‐based cohort study included participants enrolled in the Danish National Birth Cohort between 1996 and 2003. Data on MSDP were obtained from two telephone interviews during pregnancy and one interview after pregnancy. The primary outcome was contacts to the health care system. From Danish national registries, we obtained information on number and type of contacts to the general practitioner (GP), and information on the specific types of services provided. Further, we obtained information on hospital admissions, and redemption of prescribed medicine. We fitted negative binomial regression models and Cox proportional hazards regression models to estimate associations. All analyses were adjusted for socio‐economic status, birth year, and various maternal factors.ResultsWe studied 83,905 liveborn singletons and found that offspring exposed to maternal smoking in utero had more contacts to the GP in the first 10 years of life with an incidence rate ratio of 1.05, 95% confidence interval [CI] 1.04, 1.06. A higher rate of admission to hospital in 9 out of 20 categories was found, as was a higher rate of being prescribed psychoanaleptics (hazard ratio [HR] 1.41, 95% CI 1.25, 1.60), drugs for obstructive pulmonary disease (HR 1.14, 95% CI 1.14, 1.20), and antibiotics (HR 1.03, 95% CI 1.01, 1.05).ConclusionsWe found that offspring exposed to MSDP had a higher use of health care services than unexposed offspring.
Effects of short‐term storage on sperm function in fish semen: a review
Authors: Contreras Pablo , Dumorné Kelly , Ulloa‐Rodríguez Patricio , Merino Osvaldo , Figueroa Elías , Farías Jorge G. , Valdebenito Iván , Risopatrón Jennie 
Published: September 2019

AbstractStorage of refrigerated semen is a simple and inexpensive procedure that can facilitate the management and reproduction programmes in aquaculture and allows to store semen for in vitro reproduction, quality analyses, hatchery production support, selective in vitro breeding, disease diagnosis, transportation, cryopreservation and advanced molecular studies. Implementation of semen short‐term storage protocols for threatened or endangered fish represents a useful strategy for preservation of these species. Semen cold storage as technique is a useful strategy for the conservation of fish sperm. Analysing the male broodstock sperm quality during cold storage is a tool to identify the reproductive ability of cultivated fish. Thus, in this review we analysed the most relevant factors that affect sperm quality during cold storage of male broodstock semen as well as its effects on motility, viability, mitochondrial membrane potential, superoxide anion level and DNA fragmentation.
Successful preemptive therapy with single‐dose rituximab for Epstein‐Barr virus infection to prevent post‐transplant lymphoproliferative disease after pediatric hematopoietic stem cell transplantation
Authors: Kim Bo Kyung , Kang Hyoung Jin , Hong Kyung Taek , An Hong Yul , Choi Jung Yoon , Lee Jee Soo , Park Sung Sup , Shin Hee Young 
Published: September 2019

AbstractBackgroundThe efficacy of preemptive treatment containing rituximab to prevent post‐transplant lymphoproliferative disease (PTLD) in children has not yet been fully elucidated.MethodsWe analyzed 19 pediatric patients who developed high Epstein‐Barr virus (EBV) DNAemia (EBV viral load of greater than 40 000 copies/mL) after allogeneic hematopoietic stem cell transplantation (HSCT) and were preemptively administered rituximab. Rituximab was intravenously injected at a dose of 375 mg/m2 once the EBV viral load was greater than 40 000 copies/mL.ResultsIn all 19 patients, EBV DNAemia was eradicated after a median of 9 days (range, 3‐20 days), and PTLD did not occur. One patient had transient fever, and four patients did not fully recover B cell counts after transplantation. We suggested that delayed B cell recovery was caused by chronic graft‐versus‐host disease (GVHD) related drugs, not rituximab administration. And there were no other infection‐related side effects.ConclusionsIn conclusion, preemptive therapy containing rituximab is expected to reduce the incidence of PTLD after HSCT and improve post‐transplantation outcomes in children.
Optimization of a Centrifugal Impeller on Blade Thickness Distribution to Reduce Hydro-Induced Vibration
Authors: Qian Bo , Wu Peng , Huang Bin , Zhang Kai , Li Shiyang , Wu Dazhuan 
Published: September 2019

Abstract
The vibration performance of centrifugal impellers is important for pumps and hydraulic excitation is a key source of vibration. The complex internal secondary flow in the centrifugal impeller brings degradation on vibration performances. An attempt of optimization by controlling the thickness distribution of centrifugal impeller blade is given to repress the internal secondary flow and alleviating vibration. The usual method of modifying an impeller on vibration performance is applying splitter blades. In this study, an ordinarily designed impeller is improved by the optimization attempt and the optimized impeller (OPT) is compared with the prototype impeller (PRT) with traditional splitter blades. The vibration performances of the impellers, the PRT, the ordinary impeller (ODN), and the OPT, are investigated numerically and experimentally. Meanwhile, further study on the influence of the thickness distribution optimization on vibration is conducted. There is a relative velocity gradient from suction side (SS) to pressure side (PS) in impeller ODN, causing nonuniformity of energy distribution. By means of thickness distribution optimization, the impeller blade angle on the PS and SS along the blade-aligned streamwise location is, respectively, modified and therefore the flow field can be reordered. The energy transfer in impeller is also redistributed after the modification of blade thickness distribution. What is more, experimental research upon impeller PRT and impeller OPT is also complemented to support the computational fluid dynamics (CFD) results. The experimental results show that the hydraulic performance of the impellers basically agree with the CFD results and the vibration data also proves a better vibration performance of the OPT.
Control Technology Needs for Electrified Aircraft Propulsion Systems
Authors: Simon Donald L. , Connolly Joseph W. , Culley Dennis E. 
Published: September 2019

Abstract
Electrified aircraft propulsion (EAP) systems hold potential for the reduction of aircraft fuel burn, emissions, and noise. Currently, NASA and other organizations are actively working to identify and mature technologies necessary to bring EAP designs to reality. This paper specifically focuses on the envisioned control technology challenges associated with EAP designs that include gas turbine technology. Topics discussed include analytical tools for the dynamic modeling and analysis of EAP systems, and control design strategies at the propulsion and component levels. This includes integrated supervisory control facilitating the coordinated operation of turbine and electrical components, control strategies that seek to minimize fuel consumption and lessen the challenges associated with thermal management, and dynamic control to ensure engine operability during system transients. These dynamic control strategies include innovative control approaches that either extract or supply power to engine shafts dependent upon operating phase, which may improve performance and reduced gas turbine engine weight. Finally, a discussion of control architecture design considerations to help alleviate the propulsion/aircraft integration and certification challenges associated with EAP systems is provided.
The Effects of Parental Stress on Physical Activity Among Overweight and Obese Hispanic Adolescents: Moderating Role of Family Communication and Gender
Authors: Kobayashi Marissa A. , Kyoung Lee Tae , Leite Rafael O. , Noriega Esquives Blanca , Prado Guillermo , Messiah Sarah E. , St. George Sara M. 
Published: September 2019

Background: Previous literature has shown a negative relationship between parental stress and youth moderate to vigorous physical activity (MVPA). This study examined (1) the relationship between parental stress and adolescent MVPA, (2) the moderating role of family communication on this relationship, and (3) gender differences in these effects among overweight and obese Hispanic adolescents. Methods: Hispanic adolescents (N = 280, 52% female, 13.0 [0.8] y old, 44% obese, 12% severely obese) and their parents (88% female, 44.9 [6.5] y old) completed baseline measures for an efficacy trial. Adolescents self-reported MVPA in minutes per week for work, transportation, and recreation using a validated measure. Multiple regression analyses with interaction terms and multigroup methods were conducted. Results: There was a negative effect of parental stress on adolescent MVPA (β = −0.15, t = −2.018, P ≤ .05). This effect was moderated by family communication (β = 0.20, t = 2.471, P = .01), such that the association between parental stress and youth MVPA was stronger for adolescents with low levels of family communication. Furthermore, a multiple group model showed that the interaction was significant for boys (β = 0.27, t = 2.185, P = .03), but not for girls. Conclusions: Findings provide support that addressing parental stress and family communication may help facilitate MVPA among Hispanic boys, the most at-risk group for pediatric obesity.