bluuebunny/crossref_metadata_2025_split huggingface dataset:
Misery Loves Company: Presenting Symptom Clusters to Urgent Care by Patients Receiving Antineoplastic Therapy
Authors: Daly Bobby , Nicholas Kevin , Gorenshteyn Dmitriy , Sokolowski Stefania , Gazit Lior , Adams Lynn , Matays Jennie , Katzen Lauren L. , Chiu Yeneat O. , Xiao Han , Salvaggio Rori , Baldwin-Medsker Abigail , Chow Kimberly , Nelson Judith , Ross Mikel , Ng Kenneth K. , Zervoudakis Alice , Perchick Wendy , Reidy Diane L. , Simon Brett A. , Wagner Isaac 
Published: July 2018

Purpose: The Centers for Medicare & Medicaid Services (CMS) identifies suboptimal management of treatment toxicities as a care gap and proposes the measurement of hospital performance on the basis of emergency department visits for 10 common symptoms. Current management strategies do not address symptom co-occurrence. Methods: We evaluated symptom co-occurrence in three patient cohorts that presented to a cancer hospital urgent care center in 2016. We examined both the CMS-identified symptoms and an expanded clinician-identified set defined as symptoms that could be safely managed in the outpatient setting if identified early and managed proactively. The cohorts included patients who presented with a CMS-defined symptom within 30 days of treatment, patients who presented within 30 days of treatment with a symptom from the expanded set, and patients who presented with a symptom from the expanded set within 30 days of treatment start. Symptom co-occurrence was measured by Jaccard index. A community detection algorithm was used to identify symptom clusters on the basis of a random walk process, and network visualizations were used to illustrate symptom dynamics. Results: There were 6,429 presentations in the CMS symptom-defined cohort. The network analysis identified two distinct symptom clusters centered around pain and fever. In the expanded symptom cohort, there were 5,731 visits and six symptom clusters centered around fever, emesis/nausea, fatigue, deep vein thrombosis, pain, and ascites. For patients who newly initiated treatment, there were 1,154 visits and four symptom clusters centered around fever, nausea/emesis, fatigue, and deep vein thrombosis. Conclusion: Uncontrolled symptoms are associated with unplanned acute care. Recognition of the complexity of symptom co-occurrence can drive improved management strategies.
Thermal spikes from the urban heat island increase mortality and alter physiology of lizard embryos
Authors: Hall Joshua M. , Warner Daniel A. 
Published: July 2018

ABSTRACT
Effects of global change (i.e. urbanization, climate change) on adult organisms are readily used to predict the persistence of populations. However, effects on embryo survival and patterns of development are less studied, even though embryos are particularly sensitive to abiotic conditions that are altered by global change (e.g. temperature). In reptiles, relatively warm incubation temperatures increase developmental rate and often enhance fitness-relevant phenotypes, but extremely high temperatures cause death. Due to the urban heat island effect, human-altered habitats (i.e. cities) potentially create unusually warm nest conditions that differ from adjacent natural areas in both mean and extreme temperatures. Such variation may exert selection pressures on embryos. To address this, we measured soil temperatures in places where the Puerto Rican crested anole lizard (Anolis cristatellus) nests in both city and forest habitats. We bred anoles in the laboratory and subjected their eggs to five incubation treatments that mimicked temperature regimes from the field, three of which included brief exposure to extremely high temperatures (i.e. thermal spikes) measured in the city. We monitored growth and survival of hatchlings in the laboratory for 3 months and found that warmer, city temperatures increase developmental rate, but brief, thermal spikes reduce survival. Hatchling growth and survival were unaffected by incubation treatment. The urban landscape can potentially create selection pressures that influence organisms at early (e.g. embryo) and late life stages. Thus, research aimed at quantifying the impacts of urbanization on wildlife populations must include multiple life stages to gain a comprehensive understanding of this important aspect of global change.
A Practical Approach for Searching Stable Molecular Structures by Introducing Repulsive Interactions among Walkers
Authors: Shoji Mitsuo , Kayanuma Megumi , Shigeta Yasuteru 
Published: July 2018

Abstract
We propose a new algorithm that can be practically applied for searching molecular conformations without specifying the explicit reaction coordinates in advance. The basic idea is to introduce repulsive interactions among all the sampling structures (walkers) to spread the walker distributions. By increasing the strength of the repulsive interactions, walkers trapped in a local potential minimum overcome the potential barrier and can flow into other potential areas. Using this method, called the GLobal Area Search (GLAS) approach, all the walkers are optimized in parallel like a conventional geometrical optimization procedure, but in which only the repulsive force is added to the total gradient like an extra restraint term. We tested the GLAS method using simple molecules, i.e., ethane and glycine, and we could show that their conformers are properly generated. As the GLAS method has the following advantages: (i) computational time is the order of the geometrical optimizations, (ii) parallel exclusion is possible, and (iii) some GLAS trajectories are very close to the minimum energy path, the GLAS approach will be quite useful to search for stable conformations and reactivity especially for uncharacterized molecules.
Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial
Authors: Roberts Ian , Belli Antonio , Brenner Amy , Chaudhri Rizwana , Fawole Bukola , Harris Tim , Jooma Rashid , Mahmood Abda , Shokunbi Temitayo , Shakur Haleema ,   CRASH-3 trial collaborators
Published: July 2018

Background: Worldwide, traumatic brain injury (TBI) kills or hospitalises over 10 million people each year. Early intracranial bleeding is common after TBI, increasing the risk of death and disability. Tranexamic acid reduces blood loss in surgery and death due to bleeding in trauma patients with extra-cranial injury. Early administration of tranexamic acid in TBI patients might limit intracranial bleeding, reducing death and disability. The CRASH-3 trial aims to provide reliable evidence on the effect of tranexamic acid on death and disability in TBI patients. We will randomly allocate about 13,000 TBI patients to an intravenous infusion of tranexamic acid or matching placebo in addition to usual care. This paper presents a protocol update (version 2.1) and statistical analysis plan for the CRASH-3 trial. Results: The primary outcome is head injury death in hospital within 28 days of injury for patients treated within 3 hours of injury (deaths in patients treated after 3 hours will also be reported). Because there are strong scientific reasons to expect that tranexamic acid will be most effective in patients treated immediately after injury and less effective with increasing delay, the effect in patients treated within one hour of injury is of particular interest. Secondary outcomes are all-cause and cause-specific mortality, vascular occlusive events (myocardial infarction, pulmonary embolism, deep vein thrombosis, stroke), disability based on the Disability Rating Scale and measures suggested by patient representatives, seizures, neurosurgical intervention, neurosurgical blood loss, days in intensive care and adverse events. Sub-group analyses will examine the effect of tranexamic acid on head injury death stratified by time to treatment, severity of TBI and baseline risk. Conclusion: The CRASH-3 trial will provide reliable evidence of the effectiveness and safety of tranexamic acid in patients with acute TBI. Registration: International Standard Randomised Controlled Trials registry (ISRCTN15088122) 19/07/2011, and ClinicalTrials.gov (NCT01402882) 25/07/2011.
Explaining Bundle-Framing Effects with Signaling Theory
Authors: Moon Jihwan , Shugan Steven M. 
Published: July 2018

Many sellers bundle add-ons (e.g., in-flight entertainment, hotel amenities) with core services (e.g., transportation, lodging). One surprising empirical finding is that consumers often believe bundle frames provide greater value than equivalent unbundle frames ($10 > $9 + $1) despite equal all-inclusive prices. Although these context or framing effects appear irrational in isolation, the bundle-framing effect might reflect market relationships caused by underlying seller motives. We show that bundling can signal information about product appeal, that is, popularity. Specifically, only sellers of wide-appeal (popular) add-ons (e.g., well-liked entertainment, sought-after hotel amenities, standard side salads, popular excursions) have an incentive to bundle their add-ons with their core products (e.g., flights, hotel rooms, restaurant entrées, cruise trips). By contrast, sellers of narrow-appeal (niche) add-ons (e.g., unorthodox entertainment, unpopular amenities, exotic side salads, unusual excursions) find that bundling is undesirable because they lose core revenue. Consequently, bundling can convey information about horizontally differentiated markets even when the total all-inclusive price equals that of unbundling. Perhaps some presumed consumer biases can reveal market relationships. Frames provide information about the framer. The online appendix is available at https://doi.org/10.1287/mksc.2018.1097 .
Speculation and the Bond Market: An Empirical No-Arbitrage Framework
Authors: Barillas Francisco , Nimark Kristoffer 
Published: July 2018

An affine no-arbitrage asset pricing framework is developed that allows for agents to have rational but heterogeneous expectations. The framework can match both bond yields and the observed dispersion of yield expectations in survey data. Heterogeneous information introduces a speculative component in bond prices that is (i) statistically distinct from classical components such as risk premia and expectations about future short rates and (ii) quantitatively important, at times accounting for up to 125 basis points of U.S. yields. Allowing for heterogeneous expectations also changes the estimated relative importance of risk premia and expectations about future short rates in historical bond yields compared to a standard affine model. The framework imposes weaker restrictions than existing heterogeneous information asset pricing models and is thus well suited to empirically quantify the importance of relaxing the common information assumption. This paper was accepted by Tomasz Piskorski, finance.
A brief guide to borderline personality disorder in an emergency setting
Authors: Jamieson Louisa 
Published: July 2018

Overview Paramedics and ambulance staff are frequently in contact with patients who have mental health diagnoses This may be the primary reason for contacting the emergency services (e.g. self-harm, crisis or suicide ideation) or it may be incidental to their primary clinical concern. Patients in mental health crisis can be challenging and demanding. Most paramedics will not have had specific guidance on identifying or understanding the features, aetiology and responses to treatment of patients with a diagnosis of borderline personality disorder. Borderline personality disorder is associated with a high risk of self-harm, risk-taking behaviour and suicide. Building a rapport with patients is often crucial to paramedics achieving optimum patient care. There are features of borderline personality disorder that may make rapport-building more complex, and the establishment of trust harder for the clinician to achieve and maintain. There is potential for frustration and a lack of understanding to interfere with the successful delivery of person-centred care. In order to support patients with borderline personality disorder, ambulance staff need to be aware of the particular characteristics of this condition and the current best practice guidance.
Contact and Nozzle Wear from 100 Interruptions for a Puffer-Type Air Load Break Switch
Authors: Stoa-Aanensen N. , Jonsson E. , Runde M. 
Published: July 2018

One type test requirement for medium voltage load break switches is to interrupt 100 consecutive "mainly active loads". A puffer-type switch with axial-blown arc has been tested according to the 630 A/24 kV ratings. The nozzle and contact wear were measured regularly to investigate design requirements and the impact from nozzle wear on gas flow. The contact wear is only moderate, while the nozzle wear causes a decrease in pressure build-up, which in turn may influence the interruption performance.
Brain stem modeling at a system level – chances and limitations
Authors: Mikolajewski Dariusz , Duch Włodzisław 
Published: July 2018

Abstract
The topic of brain stem computational simulation still seems understudied in contemporary scientific literature. Current advances in neuroscience leave the brain stem as one of the least known parts of the human central nervous system. Brain stem lesions are particularly damaging to the most important physiological functions. Advances in brain stem modeling may influence important issues within the core of neurology, neurophysiology, neurosurgery, and neurorehabilitation. Direct results may include both development of knowledge and optimization and objectivization of clinical practice in the aforementioned medical areas. Despite these needs, progress in the area of computational brain stem models seems to be too slow. The aims of this paper are both to recognize the strongest limitations in the area of computational brain stem simulations and to assess the extent to which current opportunities may be exploited. Despite limitations, the emerging view of the brain stem provided by its computational models enables a wide repertoire of functions, including core dynamic behavior.
BCL2L12 improves risk stratification and prediction of BFM-chemotherapy response in childhood acute lymphoblastic leukemia
Authors: Avgeris Margaritis , Stamati Lamprini , Kontos Christos K. , Piatopoulou Despina , Marmarinos Antonios , Xagorari Marieta , Baka Margarita , Doganis Dimitrios , Anastasiou Theodora , Kosmidis Helen , Gourgiotis Dimitrios , Scorilas Andreas 
Published: July 2018

AbstractBackgroundRisk-adjusted treatment has led to outstanding improvements of the remission and survival rates of childhood acute lymphoblastic leukemia (ALL). Nevertheless, overtreatment-related toxicity and resistance to therapy have not been fully prevented. In the present study, we evaluated for the first time the clinical impact of the apoptosis-relatedBCL2L12gene in prognosis and risk stratification of BFM-treated childhood ALL.MethodsBone marrow specimens were obtained from childhood ALL patients upon disease diagnosis and the end-of-induction (EoI; day 33) of the BFM protocol, as well as from control children. Following total RNA extraction and reverse transcription,BCL2L12expression levels were determined by qPCR. Patients’ cytogenetics, immunophenotyping and minimal residual disease (MRD) evaluation were performed according to the international guidelines.ResultsBCL2L12expression was significantly increased in childhood ALL and correlated with higherBCL2/BAXexpression ratio and favorable disease markers. More importantly,BCL2L12expression was associated with disease remission, while the reducedBCL2L12expression was able to predict patients’ poor response to BFM therapy, in terms of M2-M3 response and MRD≥0.1% on day 15. The survival analysis confirmed the significantly higher risk of the BFM-treated patients underexpressingBCL2L12at disease diagnosis for early relapse and worse survival. Lastly, evaluation ofBCL2L12expression clearly strengthened the prognostic value of the established disease prognostic markers, leading to superior prediction of patients’ outcome and improved specificity of BFM risk stratification.ConclusionsThe expression levels of the apoptosis-relatedBCL2L12predict response to treatment and survival outcome of childhood ALL patients receiving BFM chemotherapy.
Activating Temporalities: The Political Power of Artistic Time
Authors: Bal Mieke 
Published: July 2018

Abstract
Inspired by Marx’ view of “untimely temporalities,” I connect my own conception of the need for anachronism in art history with some contemporary artworks focusing on the political importance of art in the present. The analyses of work by three contemporary artists who each bring their own aesthetic of slowness, interruption, and activism to their art leads to a conception of political art as activating rather than directly activist. In addition to Marx, especially his view of temporality, and to Henri Bergson as a major philosopher of time, the article also establishes connections with the ideas of contemporary cultural analyst Kaja Silverman. These three thinkers, each in their own way, undermine the binary oppositions on which so much of thought is based.
A Novelhybrid Bio-System for Wastewater Treatment Using Algerian Agricultural Wastes
Authors: Chikhi Sara , Bouzid Bachir , Hamitouche Adhy’a Eddine 
Published: July 2018

Abstract
The development of a new clean, easy to handle process with similar efficiency to that of the conventional process is one of the most important challenges in green chemistry investigation. In this study, a new hybrid process was investigated; coupling coagulation-flocculation with adsorption using abundant and natural bioproducts (Chitosan and Ammi visnaga). The Chitosan/Ammi visnaga (coagulation/adsorption) system was studied for its Brilliant Green dye removal capacity. This new technique seems to be a good alternative method for wastewater treatment, showing satisfactory results with high rates of elimination that range around 90 %.
The Variability of the Concentration of Bioaerosols Above the Chambers of Biological Wastewater Treatment
Authors: Michałkiewicz Michał , Kruszelnicka Izabela , Widomska Małgorzata 
Published: July 2018

Abstract
The article presents the results of research over microorganisms (psychrophilic and mesophilic bacteria and microscopic fungi) found in wastewater in denitrification and nitrification chambers and specifies the proportion of these microorganisms in bioaerosol at various levels above wastewater level (20, 50 and 100 cm). In the denitrification chamber (anoxic) in 1 cm3 of sewage there were on average 30.35 · 106 CFU of mesophilic bacteria, 72.88 · 106 CFU of psychrophilic bacteria, and 37.3 · 105 CFU of microscopic fungi. In the nitrification chamber, where the oxygen concentration ranged from 0.37 to 2.32 mg O2·dm−3 of wastewater, the number of microorganisms was lower. In 1 cm3 of wastewater there were on average 20.2 · 106 CFU of mesophilic bacteria, 51.76 · 106 CFU of psychrophilic bacteria, and 15.22 · 105 CFU of microscopic fungi. In sewage bioaerosols above these chambers, higher numbers of psychrophilic bacteria than mesophilic ones and microscopic fungi were reported. At the same time differences in the number of microorganisms at different heights above the surface of wastewater could be observed in bioaerosol, as well as between the chambers of the bioreactor. It was found that most frequently the amount of microorganisms decreased with height. The percentage emission ratio (ER) of microorganisms in bioaerosols coming from wastewater accounted for only a fraction of a percent and ranged from 1.13 · 10−8 % (microscopic fungi over the denitrification chamber) to 24.53 · 10−9 % (psychrophilic bacteria over the denitrification chamber). It was found that the process of mixing, aeration of wastewater, have an effect on the emission of microorganisms.
Effect of pH on the Production of Volatile Fatty Acids in Dark Fermentation Process of Organic Waste
Authors: Grzelak Justyna , Ślęzak Radosław , Krzystek Liliana , Ledakowicz Stanisław 
Published: July 2018

Abstract
The aim of this study was to investigate the effect of pH on the dark fermentation process of kitchen waste by specifying the composition of the volatile fatty acids (VFA), H2 and by drawing the carbon balance. Studies were carried out in 8 dm3 batch bioreactor in mesophilic conditions. The kitchen waste from the city of Lodz were used as a substrate. Based on the study, it was observed that most of the VFA was produced during the first two days of the process, while in the following days the production was diminished. The highest production of VFA (19.5 g/dm3) was obtained in the bioreactor, where the pH was 7 and 8. Analyzing the produced VFA it was observed that mostly the acetic and butyric acid had been produced. Most of acetic acid (over 70 %) was obtained in fermenter with pH 7 and 8. In contrast, most of the butyric acid (over 40 %) was in the bioreactor with a pH of 6. Production of H2 was in the range from 4.29 to 26.5 dm3, wherein the largest amount of H2 was created in the bioreactor with a pH of 6.
Eco-Investments - Life Cycle Assessment of Different Scenarios of Biomass Combustion
Authors: Nitkiewicz Tomasz , Ociepa-Kubicka Agnieszka 
Published: July 2018

Abstract
The article presents the results of life cycle assessment of different scenarios of biomass use to produce energy in a selected company. The study is made on the case of Lesaffre Polska S.A. and its facility in Wolczyn which is one of the most modern biomass plants in Central Europe. The company is one of the leaders of using the environmental criteria in its strategic decision-making. Its goal is to avoid any waste and to form its own circular business system. One of its recent investments is a biomass fired steam boiler that uses agricultural and woody biomass to produce energy. Previously, biomass was sold to power plant and co-fired with coal. The scope of the paper is to assess the actual change in the environmental impact of biomass use in the Wolczyn facility. For that purpose, the life cycle assessment is used with the ReCiPe endpoint indicator. The assessment is based on the comparison of two scenarios: one assuming the biomass combustion in a new boiler, and the second one, assuming co-firing biomass with coal. The results of the study show that the investment is making a significant difference as far as the overall environmental impact is. Through avoiding the co-firing related emissions the company makes a big step ahead towards the decrease of their environmental impacts. The analysis shows that the significant impact in the co-firing scenario is posed in such categories as fossil depletion, climate change with impacts on human health and on ecosystems, particulate matter formation and agricultural land occupation. In the biomass combustion scenario, the above categories are complemented with metal depletion, natural land transformation, urban land occupation and human toxicity categories but with 4 times decrease of the overall impact. The study also shows that the change of the combustion system makes the most significant difference, while all the other factors, like biomass cultivation and processing, biomass transport have much lesser impact.
Inner structure in real vector spaces
Authors: García-Pacheco Francisco Javier , Naranjo-Guerra Enrique 
Published: July 2018

Abstract
Internal points were introduced in the literature of topological vector spaces to characterize the finest locally convex vector topology.
In this manuscript we generalize the concept of internal point in real vector spaces by introducing a type of points, called inner points, that allows us to provide an intrinsic characterization of linear manifolds, which was not possible by using internal points. We also characterize infinite dimensional real vector spaces by means of the inner points of convex sets. Finally, we prove that in convex sets containing internal points, the set of inner points coincides with the one of internal points.