bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards further Understanding the Structural Requirements of Combretastatin- like Chalcones as Inhibitors of Microtubule Polymerization
Authors: Dhingra Naveen , Kar Anand , Sharma Rajesh 
Published: December 2018

Background:
Microtubules are dynamic filamentous cytoskeletal structures which play
several key roles in cell proliferation and trafficking. They are supposed to contribute in the development
of important therapeutic targeting tumor cells. Chalcones are important group of natural
compounds abundantly found in fruits & vegetables that are known to possess anticancer activity.
We have used QSAR and docking studies to understand the structural requirement of chalcones for
understanding the mechanism of microtubule polymerization inhibition.

Methods:
Three dimensional (3D) QSAR (CoMFA and CoMSIA), pharmacophore mapping and
molecular docking studies were performed for the generation of structure activity relationship of
combretastatin-like chalcones through statistical models and contour maps.

Results:
Structure activity relationship revealed that substitution of electrostatic, steric and donor
groups may enhance the biological activity of compounds as inhibitors of microtubule polymerization.
From the docking study, it was clear that compounds bind at the active site of tubulin protein.

Conclusion:
The given strategies of modelling could be an encouraging way for designing more
potent compounds as well as for the elucidation of protein-ligand interaction.
Cement Arthrodesis of the Knee with a Custom Long Recon Nail After Failed Total Knee Arthroplasty: Surgical Technique and Results
Authors: DeBaun Malcolm R. , Goodman Stuart B. , Lowenberg David W. 
Published: December 2018

Background and Objective:
Persistent periprosthetic joint infection (PJI) is a devastating complication after Total Knee Arthroplasty (TKA). We hypothesize that our novel treatment algorithm utilizing a customized knee spanning recon nail combined with an antibiotic eluting cement spacer improves ambulation status and prevents recurrent PJI in patients with failed TKA and severe bone loss.

Methods:
In a retrospective case series, 15 consecutive patients who underwent knee arthrodesis after failed ipsilateral TKA secondary to infection from 2004-2017 with at least 1 year of follow-up were enrolled. The average age of patients at the time surgery was 68 (range 50-81) years with an average follow-up of 3.2 (range 1-6) years. Post-surgical ambulation status and eradication of index infection were analyzed as primary outcomes using McNemar’s test for before-and-after study design with p<0.05 for significance.

Results:
Cement arthrodesis significantly improved ambulation with 67% (10/15) of patients unable to ambulate before arthrodesis and 93% (14/15) of patients able to ambulate at final follow-up (p=0.004). The complication rate was 20% (3/15). There were no periprosthetic fractures. Amongst patients who presented with active PJI, 91% (10/11) had eradication of their index infection final follow-up (p=0.002). Overall prevention of recurrent index infection was 93% (14/15) (p=0.0001).

Conclusion:
Cement arthrodesis utilizing a custom knee spanning recon nail combined with an antibiotic eluting spacer improves ambulation status and prevents or treats recurrent infection in the majority of patients who have failed total knee arthroplasty.
Product Innovation in the Crafts Sector
Authors: Sarmento Maria , Amorim Marlene , Dias Marta Ferreira , Madaleno Mara 
Published: December 2018

Background:
Innovation can result from progressive or significant changes to existing products leading to improvements in performance and user value. This is the type of innovation that is more easily perceived by the consumer, as it results in the creation of new products or the improvement of existing ones. Innovation in the Crafts Sector is a relevant topic to address market changes, and meet evolving consumer preferences. In this vein, artisans need to meet the calls for regularly investing in the design of new products and processes, with the purpose of achieving the sustainability of their business.

Methods:
This article addresses the existing calls for contextualizing the crafts sector and for fostering product innovation in this area, by investigating the barriers and problems faced by artisans, as well as by exploring existing experiences in overcoming them. The article builds on data collected in five European countries, under the scope of the Erasmus+ Project Craftsmanship+ “Fostering a New and Competitive Approach to Crafts and Semi Industrial high added-value sectors”1.

Results and Conclusion:
The aim is to analyze the importance of the crafts sector in a European context. This article contributes in a timely manner to the understanding of the crafts sector by paying attention to the obstacles that artisans face in order to ensure the sustainability of their business by introducing product innovation into their organization and/or market. This study offers a collection of innovation experiences in realities that are very significant for territorial identity, and thus aims to provide an incentive for further research.
Diseño de una cubierta hiperbólica plegable tensada
Authors: Morales Guzmán Carlos Cesar 
Published: December 2018

RESUMEN
Se procesa la adecuación geométrica descriptiva de un sistema transformable, y cómo simular la modelación de sus partes por medio de un software que ayuda a concebir las interpretaciones de diseño de una geometrización hiperbólica. La modelación a escala apoya mucho a interpretar los movimientos de un sistema transformable, para generar un sistema flexible, el que se propone una piel de tenso estructura que ayuda a crear una estructura fácil de transportar y construir en sitios variables. Por esto, la investigación se centró en procesar los detalles experimentales y diseñarlos en 3D, para verificar la pertinencia de diseño de uniones articuladas.
Os Sítios Simbólicos de Pertencimento dos colonos e dos caboclos do oeste de Santa Catarina
Authors: Dorigon Clovis , Renk Arlene 
Published: December 2018

Tendo como ponto de partida os hábitos alimentares regionais e os contextos em que tais alimentos são produzidos e consumidos, busca-se neste texto problematizar a abordagem teórica dos sítios simbólicos de pertencimento, ainda de pouca circulação no Brasil. A partir de dados empíricos relacionados aos hábitos alimentares e das festividades organizadas em torno do consumo de alimentos originários do saber-fazer dos agricultores, analisa-se a presença na região oeste de Santa Catarina de dois Sítios Simbólicos de Pertencimento. Um deles formado pelos descendentes de imigrantes europeus (italianos, alemães e poloneses). O outro pelos caboclos, população pré-existente à chegada dos colonos. Os caboclos foram excluídos de suas terras para dar lugar àqueles. Estabelecem-se comparações entre a noção de Sítio com outras noções, em especial com a de habitus de Bourdieu e a de economia substantiva de Karl Polanyi. Dentre as conclusões sublinha-se que a noção de sítios simbólicos de pertencimento oferece recursos ao estudar o homo situs como animal territorial. No caso analisado, tem-se um território partilhado com duas territorialidades, marcadas por processos históricos distintos, a inclusão pela colonização, para um grupo e a exclusão para outro grupo. A escolha do idioma da comida como fio condutor permitiu traçar o homo situs apontando as peculiaridades, a processualidade e os desdobramentos dos entrecruzamentos das histórias.
Entre bastidores: etnografía de la política pública para los afrodescendientes en Cali, Colombia
Authors: Martínez B. Sandra Patricia 
Published: December 2018

El artículo analiza el proceso de formulación de la política pública dirigida a los afrocolombianos residentes en Cali, a partir de la etnografía de las interacciones entre los
actores que intervienen en su producción. Para ello, retoma la aproximación antropológica a las políticas públicas, desde la cual se plantea la necesidad de ver en ellas un proceso negociado e inserto en una compleja red de agentes, intereses y relaciones que marcan el rumbo incierto que estas pueden llegar a tomar. La etnografía, realizada en dos de los escenarios de discusión de esta política, permitió constatar la eficacia simbólica de las ceremonias públicas en tanto actos de teatralización de lo oficial, así como aproximarse a las construcciones discursivas que los actores elaboran en torno al Estado.
CINCO CONCEITOS DE RELIGIÃO
Authors: Dos Santos Ricardo Assarice 
Published: December 2018

Diante do contínuo debate sobre a adequação e a definição do conceito de “religião”, este artigo fomenta a necessidade de as ciências sociais se tornarem mais autocríticas a respeito dos vários e inconstantes –usos do termo. Como este trabalho mostra, são três os usos mais dominantes: religião como crença/significado, religião como identidade e religião como relações sociais estruturadas. Por outro lado, alguns usos, que já foram importantes, são atualmente recessivos, incluindo abordagens marxistas de religião como ideologia e concepções parsonianas de religião como normas e valores. Novos usos estão emergindo, tais como os de religião “material”, de religião como discurso e de religião como prática. Levando em consideração esses fatos, este artigo propõe uma taxonomia dos cinco principais usos do termo. Discorre sobre pertinência deles e aponta que onde ainda haja oclusões: acima de tudo, no que diz respeito a relações “supersociais” ou “metassociais” com seres, forças e energias não humanos ou quase humanos.
KELAYAKAN ISI DAN BAHASA BUKU AJAR BAHASA INDONESIA SEKOLAH MENENGAH PERTAMA KELAS VIII KURIKULUM 2013 EDISI REVISI 2017 PENERBIT KEMENTERIAN PENDIDIKAN DAN KEBUDAYAAN
Authors: Ridho Pradita Muhammad , Lubis Fitriani 
Published: December 2018

Menurut Masnur Muslich (2010: 50) buku teks adalah buku yang berisi uraian bahan tentang mata pelajaran atau bidang studi tertentu, yang disusun secara sistematis dan telah diseleksi berdasarkan tujuan tertentu, orientasi pembelajaran, dan perkembangan siswa, untuk diasimilasi.dalam Peraturan Menteri Pendidikan Nasional Republik Indonesia (Permendiknas RI) No. 2 Tahun 2008 tentang buku Pasal 4 Ayat 1 disebutkan bahwa “Buku teks pada jenjang pendidikan dasar dan menengah dinilai kelayakan pakainya terlebih dahulu oleh Badan Standar Nasional Pendidikan (BSNP) sebelum digunakan oleh pendidik dan atau peserta didik sebagai sumber belajar.” Penelitian ini bertujuan untuk mengetahui kelayakan isi dan kelayakan bahasa pada buku ajar Bahasa Indonesia SMP kelas VIII edisi revisi 2017 penerbit Kementerian Pendidikan dan Kebudayaan berdasarkan kriteria BSNP. Buku ajar Bahasa Indonesia SMP kelas VIII edisi revisi 2017 penerbit Kementerian Pendidikan dan Kebudayaan dari segi kelayakan isi sudah dikategorikan pada kategori sangat layak dengan persentase 84,54% dan segi kelayakan bahasa juga sudah dikategorikan pada kategori sangat layak dengan persentase 88,38%.Hasil penelitian ini menunjukkan bahwa buku ajar Bahasa Indonesia SMP kelas VIII edisi revisi 2017 penerbit Kementerian Pendidikan dan Kebudayaansangat layak untuk digunakan untuk proses belajar mengajar dikelas.
PENGARUH STRATEGI PEMBELAJARAN AKTIF TIPE THE POWER OF TWO TERHADAP PRESTASI AKADEMIK MAHASISWA PADA MATA KULIAH MICROTEACHING
Authors: Saragih Hasan , Dewi Saragih Sri Rahmah , Lubis Fitriani , Endriani Dewi 
Published: December 2018

Penelitian ini bertujuan mengetahui prestasi mahasiswa penggunaan strategi pembelajaran aktif tipe the power of two pada mata kuliah microteaching Tahun akademik 2017/2018.Sampel dalam penelitian ini diambil dengan menggunakan teknik Cluster Random Sampling yaitu pada penelitian ini adalah mahasiswasemesterVIIA sebagai kelas eksperimen dan VIIB sebagai kelas kontrol dan jumlah setiap semester adalah 30 mahasiswa. Jenis penelitian yang digunakan pada penelitian ini adalah quasi eksperimen (eksperimen semu) dan menggunakan tes yang berbentuk uraian 5 soal. Dari hasil perhitungan pretes dan protes, data tersebut diuji kedalam pengujian normalitas dan homogenitas dari kedua kelas, dinyatakan berdistribusi normal dan homogen. Selanjutnya dilakukan pengujian hipotesis diperoleh thitung = 4,53 dan ttabel = 2,002 dengan dk = 30 + 30 – 2 = 58 dan a = 0,05 maka thitung> ttabel yaitu 4,53 > 2,002, sehingga hipotesis nol ditolak,sekaligus menerima hipotesis alternatif. Sehingga dapat disimpulkan bahwa adapengaruh strategi pembelajaran aktif tipe The Power Of Two terhadap prestasi akademik mahasiswa pada mata kuliah microteaching.
PENGARUH KEPERCAYAAN, PERSEPSI HARGA, DAN SIKAP TERHADAP NIAT BELI KEMBALI DI SITUS LAZADA
Authors: Adinata Kenny Jaya , Yasa Ni Nyoman Kerti 
Published: December 2018

Tujuan dari penelitian ini adalah menganalisis pengaruh kepercayaan, pengaruh persepsi harga, dan sikap terhadap niat beli kembali di situs Lazada.Populasi dalam penelitian ini adalah masyarakat di Kota Denpasar yang pernah berbelanja online di Lazada. Ukuran sampel 108 responden, dengan menggunakan metode Purposive Sampling. Penelitian ini dilakukan dengan teknik analisis Regresi Linier Berganda. Hasil penelitian menemukan bahwa kepercayaan, persepsi, dan sikap berpengaruh positif dan signifikan terhadap niat beli kembali di situs Lazada. Implikasi dari hasil penelitian ini adalah pertama implikasi teoritis penelitian ini dapat memperjelas hubungan pengaruh kepercayaan, persepsi harga, dan sikap terhadap niat beli kembali secara online. Kedua implikasi praktis dari penelitian ini diharapkan bisa di gunakan oleh pihak Lazada untuk menumbuhkan sikap positif kepada konsumen, menumbuhkan kepercayaan kepada konsumen, dan bisa mengkomunikasikan harga yang wajar kepada konsumen sertaa pihak Lazada dapat merumuskan strategi niat beli kembali kepada konsumen Lazada di Kota Denpasar.

Kata kunci: kepercayaan, persepsi harga, sikap dan niat beli kembali
Authors: Putra Made Pramana , Aksari Ni Made Asti 
Published: December 2018

The purpose of this research is to know the difference of brand equity between Indocafe Coffee product with Good Day Coffee Powder product. This research was conducted in Denpasar City. Determination of Denpasar as a research location is based on data of Central Bureau of Statistics Year 2016 which shows Denpasar as the region having highest food and non-food expenditure level in Bali Province. The number of samples taken as many as 150 respondents, using the method of Purposive Sampling. Purposive sampling is the determination of samples with certain considerations. The analysis technique used is Descriptive Analysis and T-Test technique. Based on the results of the research can be seen that there are differences in brand awareness, brand association, perceived quality and brand loyalty between Indocafe instant powder coffee products with Good Day brand in Denpasar.
Keywords: comparison, brand, brand equity
O universo ficcional das declamações de Calpúrnio Flaco
Authors: Pontes Jefferson Da Silva 
Published: December 2018

A tradição dos manuscritos nos legou cinquenta e três fragmentos de declamações de autoria de Calpúrnio Flaco, como, convencionalmente, a crítica tem chamado o autor desse conjunto de declamações conhecido como Excerpta. Quanto à datação desses fragmentos na história da literatura latina, algumas informações extraídas dos próprios textos, bem como o estilo da escrita e a recorrência de certos temas foram utilizadas para contextualizá-los nos primeiros séculos do Império Romano. No que tange aos temas, Sussman (1994) é categórico ao afirmar que o retrato pintado a partir das declamações de Flaco, assim como as leis que regem os casos e as situações propostas para a confecção dos discursos são muito distantes do cotidiano e das práticas forenses rotineiras à época em que foram escritas. Diante dessas informações, este artigo tem por objetivo mostrar o universo ficcional criado por Calpúrnio Flaco através dos cinquenta e três fragmentos de declamações a que temos acesso.
Public Policy and Recognition of Foreign Divorces: Zhang v Lin and Marzara v Marzara
Authors: Robertson Gerald B. 
Published: December 2018

Two recent cases — one from Alberta and the other from British Columbia — deal with the power of a Canadian court to refuse recognition of a foreign divorce on grounds of public policy. As is the case with foreign judgments generally, a foreign divorce that would otherwise be valid and enforceable in Canada will be denied recognition if its enforcement would be contrary to fundamental Canadian public policy. While the existence of this principle is well-established, its scope is quite narrow and it is rarely applied. Hence, it is interesting that in both cases discussed in this case comment, the public policy defence was successfully invoked to defeat recognition of the foreign divorce.This case comment describes the circumstances which gave rise to the application of the public policy defence in these two cases, and then discusses whether its application was appropriate.
Reconciliation and Conflict: A Review of Practice
Authors: Snyder Emily 
Published: December 2018

In this article I provide a review of two connected events. The first is the conference "Prairie Perspectives on Indian Residential Schools, Truth and Reconciliation," which was held in June 2010 in Winnipeg, Manitoba. This conference was just one of many concurrent events taking place at the Truth and Reconciliation Commission of Canada's first national event. Specific themes and aspects of the conference are covered here. Secondly, I parallel my discussion of the conference to my experiences with the national event - experiences can be complex and do not happen in isolation from the broader context around them. Overall, I argue that while the conference and the national event made some meaningful contributions to ongoing dialogue about reconciliation in Canada, it is clear that understanding how to deal with and discuss the conflict that arises from discussions of residential school, "race relations," and reconciliation more broadly is an ongoing learning experience. I offer some recommendations concerning how conflict could be better dealt with at future conferences and national events. Reconciliation processes can be more effective if there is not only space for dissent but, most importantly, that mechanisms are in place for encouraging productive discussions about the conflict that arises and that will continue to arise.
Violence is Not Conflict: Why it Matters in Restorative Justice Practice
Authors: Edwards Alan , Haslett Jennifer 
Published: December 2018

The rapid growth of restorative justice programs calls for greater self-reflection and a higher standard of practice in the restorative justice field. This article addresses the distinction between violence and conflict, and the significant implications of this difference, in the restorative justice process. It offers insight into violence and victimization and sets out a number of approaches beneficial to helping solidify these important distinctions and in linking explanations to practice. Failure to understand violence and conflict as distinct concepts may potentially leave people and communities at risk of further harm.
The Northern Territory Emergency Response: The More Things Change, The More They Stay the Same
Authors: Watson Nicole 
Published: December 2018

The Northern Territory Emergency Response (NTER) was a raft of measures introduced by the Commonwealth of Australia in response to allegations of child sexual abuse in Northern Territory Aboriginal communities. The measures included the compulsory acquisition of Aboriginal lands, the quarantining of welfare payments, prohibitions on alcohol, and the vesting of expansive powers in the Commonwealth Minister to intervene in the affairs of Aboriginal organizations. This article aims to provide a brief historical background of Aboriginal people's experiences with the law in Australia, discuss certain provisoins of the NTER, and, finally, examine the consequences three years after the implementation of the NTER. Through this analysis, the author suggests that history remains a powerful influence, resulting in the NTER being based on assumptions of Aboriginal people that are grounded in a racist past. Further, independent studies have shown that the NTER has been largely ineffective at accomplishing its stated objectives.
Creating a Path by Walking It - A Year in Review of Pohna: Keepers of the Fire
Authors: Erickson Karen , LaBoucane-Benson Patti , Hossack Fiona 
Published: December 2018

Youth involvement in criminal activity and gangs is a complex problem. This article examines Pohna: Keepers of the Fire, a gang intervention and diversion program for at risk youth. The program seeks to guide at risk youth away from criminal activity by creating a place where youth are valued and their strengths are used to build their connections and responsibilities to the community. There is no simple and straightfoward answer to addressing the problem of youth involvement in criminal activity and gangs. However, from our analysis of five case studies, we have learned that in order to develop effective programs and interventions for at risk youth, we need to focus our attention on learning from them and our interactions with them. To effectively support the youth involved in Pohna, we need to understand and address the broader forces at work that both strengthen and undermine their resiliency.
TREINAMENTO RESPIRATÓRIO EM INDIVÍDUOS SAUDÁVEIS
Authors: Barros Thaís Carvalho , Pinheiro Áxel José Siqueira , Oliveira Luciana Nunes de , Zani Henrique Poletti , Vento Daniella Alves 
Published: December 2018

Comparar a efetividade do Threshold IMT e do Voldyne no fortalecimento muscular respiratório de jovens saudáveis através de um protocolo estruturado. A pesquisa envolveu jovens saudáveis, divididos aleatoriamente em grupo threshold (GT) e grupo voldayne (GV), e submetidos a um protocolo de treinamento, realizado em 10 sessões, duas vezes por semana. O protocolo consistiu em inspirações com dispositivos realizados em 3 séries de 15 repetições partindo do volume residual e alcançando a capacidade pulmonar total. Adotou-se para o grupo GT uma carga de 40% da pressão inspiratória máxima (Pimáx). Foram submetidos a avaliação e treinamento 20 jovens distribuídos nos grupos (GT n-10 e GV n-10). Houve aumento relevante da força muscular respiratória em ambos os grupos, amostra apresentou um alto aumento de 15,43% e 35,45% no pós intervenção na Pimáx, em GT (p <0,004) e GV (p <0,016), respectivamente. Comparando os efeitos dos dispositivos utilizados para a intervenção por ANOVA twoway em GT e GV, não foi demonstrada diferença entre dois tipos de tratamento (p = 0,22). Ambos os dispositivos apresentaram resultados satisfatórios no fortalecimento muscular respiratório. No entanto, o dispositivo Voldyne, um incentivo que fornece biofeedback ao indivíduo, apresentou melhores resultados clínicos quando comparado ao dispositivo Threshold IMT.
X VE Y KUŞAKLARININ KARİYER UYUM YETENEK DÜZEYLERİNİ BELİRLEMEYE YÖNELİK BİR ARAŞTIRMA
Authors: KALFAOĞLU Serap 
Published: December 2018

X kuşağı bireyleri ile Y kuşağı bireylerinin mevcut işlerine ait tutum, davranış, değer, beklenti, istek ve ihtiyaçları değişkenlik göstermektedir. Örgütlerin istihdam ettikleri çalışanlar adına bahsi geçen kuşak farklılıklarından doğan niteliklerin farkına varmaları ve bu doğrultuda kariyer planlaması yapmaları gerek örgütsel gerekse de bireysel başarıya ulaşmayı sağlayabilmektedir. Bu bağlamda, bu araştırmada, 1965-1979 yılları arasında doğan X kuşağı çalışanlarının ve 1980-2000 yılları arasında doğan Y kuşağı çalışanlarının kariyer uyum yetenek düzeylerini karşılaştırmalı olarak incelemek ve aralarındaki farkları ortaya koymak amaçlanmıştır. Bu amaçla, Konya, Selçuklu bölgesinde liselerde görev yapan 182 öğretmen üzerinde bir anket gerçekleştirilmiştir. Elde edilen veriler SPSS İstatistik Programı ile analiz edilmiştir. Bulguların elde edilmesi ve yorumlanması için frekans analizi, geçerlik (faktör) analizi, güvenilirlik analizi ve Mann Whitney U analizi kullanılmıştır. Analiz sonuçlarına göre öğretmenlerin kariyer uyum becerilerinin (kaygı, kontrol, merak ve güven düzeyleri), bahsi geçen kuşaklara göre anlamlı bir farklılık göstermediği belirlenmiştir.