bluuebunny/crossref_metadata_2025_split huggingface dataset:
A porcine ex vivo lung perfusion model to investigate bacterial pathogenesis
Authors: Dumigan Amy , Fitzgerald Marianne , Sá Pessoa Graca Santos Joana , Hamid Umar , O’Kane Cecilia M. , McAuley Danny F. , Bengoechea Jose A. 
Published: July 2019

ABSTRACTThe use of animal infection models is essential to understand microbial pathogenesis and to develop and test treatments. Insects, and 2D and 3D tissue models are increasingly being used as surrogate for mammalian models. However, there are concerns whether these models recapitulate the complexity of host-pathogen interactions. Here, we developed theex vivolung perfusion (EVLP) model of infection using porcine lungs to investigateKlebsiella pneumoniae-triggered pneumonia as model of respiratory infections. The porcine EVLP model recapitulates features ofK. pneumoniae-induced pneumonia lung injury. This model is also useful to assess the pathogenic potential ofK. pneumoniaeas we observed that the attenuatedKlebsiellacapsule mutant strain caused less pathological tissue damage with a concomitant decrease in the bacterial burden compare to lungs infected with the wild type. The porcine EVLP model allows assessment of inflammatory responses following infection; similar to the mouse pneumonia model, we observed an increase ofil-10in the lungs infected with the wild type and an increase ofifn-γin lungs infected with the capsule mutant. This model also allows monitoring phenotypes at the single-cell level. Wild-typeK. pneumoniaeskews macrophages towards an M2-like state. In vitro experiments probing pig bone marrow-derived macrophages uncovered the role of the M2 transcriptional factor STAT6, and thatKlebsiella-inducedil10expression is controlled by p38 and ERK.Klebsiella-induced macrophage polarization is dependent on the capsule. Altogether, this study support the utility of the EVLP model using pig lungs as platform to investigate the infection biology of respiratory pathogens.IMPORTANCEThe implementation of infection models that approximate human disease is essential to understand infections and for testing new therapies before they enter into clinical stages. Rodents are used in most of pre-clinical studies, although the differences between mouse and man have fuelled the conclusion that murine studies are unreliable predictors of human outcomes. Here, we have developed a whole lung porcine model of infection using the establishedex vivolung perfusion (EVLP) system established to re-condition human lungs for transplant. As a proof-of-principle, we provide evidence demonstrating that infection of the porcine EVLP with the human pathogenK. pneumoniaerecapitulates the known features ofKlebsiella-triggered pneumonia. Moreover, our data revealed the porcine EVLP model is useful to reveal features of the virulence ofK. pneumoniaeincluding the manipulation of immune cells. Altogether, this study supports the utility of the EVLP model using pig lungs as surrogate host for assessing respiratory infections.
Micro-probing enables high-resolution mapping of neuronal subpopulations using fMRI
Authors: Carvalho Joana , Invernizzi Azzurra , Ahmadi Khazar , Hoffmann Michael B. , Renken Remco J. , Cornelissen Frans W. 
Published: July 2019

AbstractThe characterization of receptive field (RF) properties is fundamental to understanding the neural basis of sensory and cognitive behaviour. The combination of non-invasive imaging, such as fMRI, with biologically inspired neural modeling has enabled the estimation of population RFs directly in humans. However, current approaches require making numerous a priori assumptions, so these cannot reveal unpredicted properties, such as fragmented RFs or subpopulations. This is a critical limitation in studies on adaptation, pathology or reorganization. Here, we introduce micro-probing (MP), a technique for fine-grained and assumption free characterisation of subpopulation RFs. Without specific stimuli or adapted models, MP mapped the bilateral RFs characteristic of observers with a congenital pathway disorder. Moreover, in healthy observers, MP revealed voxels that capture the activity of multiple neuronal subpopulations. Thus, MP provides a versatile framework to visualize, analyze and model, without restrictions, the diverse RFs of cortical subpopulations in health and disease.
Analysis of the influence of soft soil grouting on the metro tunnel based on field measurement
Authors: Ding Zhi , Zhang Xiao , Yin Xinsheng , Jiang Jiqing 
Published: July 2019

Purpose
This paper aims to analyse the effect of soft soil grouting on the deformation of the closed shield tunnel with the measured data.

Design/methodology/approach
Combining the measured data of vertical, horizontal and convergence deformation of the adjacent tunnel during the grouting construction in foundation pit engineering, the influence of grouting on metro tunnel in soft soil area is analyzed.

Findings
The researches indicate that early grouting has the main effect on the horizontal displacement of the tunnel; Due to the disturbing effect of the uninterrupted grouting construction on the soil and the transfer pressure of the rheological soil to the bottom of the tunnel, the tunnel is obviously lifted; And the convergence deformation of the tunnel increases caused by the overburden pressure in the vertical direction, so that the tunnel appears the phenomenon of staggered seam, large opening of bolted joint, damaged segment even leakage of water.

Originality/value
The study based on the field monitoring data is rarely reported, especially the topic about inadvertent grouting in soft soil area is likely to cause severe deformation of adjacent metro tunnel.
Flipped classroom pedagogy
Authors: Das Ashish , Lam Tri Khai , Thomas Susan , Richardson Joan , Kam Booi Hon , Lau Kwok Hung , Nkhoma Mathews Zanda 
Published: July 2019

PurposeThe purpose of this paper is to illustrate the implementation of the flipped classroom method in teaching the course and to investigate the student’s perceived helpfulness, learning outcomes and satisfaction in respect of the pre-class learning videos.Design/methodology/approachPre-class learning videos were integrated into a course to encourage students to acquire knowledge before lectures and workshops. Having completed the flipped classroom, a delivery questionnaire containing all items was distributed to all of the participants. The data collected were analysed statistically, using a structured equation modelling technique.FindingsFindings indicate that the perceived quality of experience of using videos before lectures and workshops has a positive influence on the perceived helpfulness of the pre-class learning videos. Furthermore, the perceived helpfulness of the pre-class learning videos has a positive effect of the acquisition perceived learning outcomes. The perceived helpfulness of the pre-class learning videos also has a positive impact on the student satisfaction with the course. Finally, there is a positive and causal relationship between the perceived learning outcomes and student’s satisfaction with the course.Originality/valueAnalysis reveals that the learning process and student satisfaction are improved by using pre-class learning videos.
Fostering preservice teacher agency in 21st century writing instruction
Authors: Jensen Amber 
Published: July 2019

PurposeThis paper aims to recommend that English educators engage preservice teachers (PSTs) in thinking and acting agentively in twenty-first century writing instruction by prompting them to examine and (re)construct discourses around identity, beliefs and teaching contexts. It explores metacognitive interventions that supported one PST to assume agency to implement twenty-first century writing pedagogies that challenged institutional and curricular norms.Design/methodology/approachA case study design was used to explore how one PST enacted agency in teaching twenty-first century writing during student teaching. Data were collected from five stimulated recall interviews that prompted metacognition over a four-month internship semester. Emerging themes were analyzed using content analysis.FindingsDuring interviews, the PST constructed narratives about herself, her beliefs and her teaching context in ways that catalyzed her agency to enact twenty-first century writing pedagogies in planning for instruction, framing learning with her students and negotiating with her colleagues. The PST perceived metacognitive intervention as a supportive framework for activating her agency to both “see” and “sell” (Nowacek, 2011) possibilities for implementing twenty-first century writing instruction in her first teaching context.Originality/valueWhile most existing literature on teacher agency focuses on practicing teachers, this paper focuses on activating agency during teacher preparation. It draws upon theories of regulative discourse (Mills, 2015), transfer (Nowacek, 2011) and metacognition as constructs for agency to identify how English educators can prepare PSTs as agents for change.
Effects of iron content on tribological properties of Cu-Fe-based friction material
Authors: Zheng Yanxin , Liu Ying , Zheng Feng , Song Qingsong , Zhang Caili , Wang Jian , Dong Nan , Shi Aijuan , Han Peide 
Published: July 2019

Purpose
The purpose of this study is to investigate the effect of iron content on the friction and wear performances of Cu–Fe-based friction materials under dry sliding friction and wear test condition.

Design/methodology/approach
Cu–Fe-based friction materials with different iron content were prepared by powder metallurgy route. The tribological properties of Cu–Fe-based friction materials against GCr15 steel balls were studied at different applied loads and sliding speeds. Meanwhile, microstructure and phases of Cu–Fe-based friction materials were investigated.

Findings
Cu–Fe-based friction materials with different iron content are suitable for specific applied load and sliding speed, respectively. Low iron content Cu–Fe-based friction material is suitable for a high load 60 N and low sliding speed 70 mm/min and high iron content Cu–Fe-based friction material will be more suitable for a high load 60 N and high sliding speed 150 mm/min. The abrasive wear is the main wear mechanism for two kinds of Cu–Fe-based friction materials.

Originality/value
The friction and wear properties of Cu–Fe-based friction materials with different iron content were determined at different applied loads and sliding speeds, providing a direction and theoretical basis for the future development of Cu–Fe-based friction materials.
Microstructure and tribological property of self-lubrication CBN abrasive composites containing molybdenum disulfide
Authors: Zhao Biao , Ding Wenfeng , Kuang Weijie , Fu Yucan 
Published: July 2019

Purpose
This paper aims to evaluate the influence of molybdenum disulfide (MoS2) concentrations (5, 7.5, 10, 12.5 and 15 Wt.%) on the microstructure and tribological property of the self-lubrication cubic boron nitride (CBN) abrasive composites.

Design/methodology/approach
Three point bending method and rotating sliding test are used to evaluate the flexural strength and tribological property of self-lubricating CBN abrasive composites. Microstructure, wear morphology of the ball and scratch are supported by scanning electron microscopy, optical microscope and three-dimensional confocal microscopy, etc.

Findings
The MoS2 concentration has a significant influence on the interface microstructure between CBN abrasives and matrix alloys, and thus, affects the flexural strength of CBN abrasive composites. The grain fracture modes of CBN abrasive composites are transformed from the transgranular fracture into intergranular fracture as the MoS2 concentrations increase. Additionally, the friction coefficient of as-sintered samples decreases with the MoS2 concentrations. The MoS2 concentrations of 10 Wt.% are final determined to fabricate self-lubricating composites in basis of the mechanical and lubricating property.

Originality/value
The ball is fabricated under vacuum sintering process. The tribological property of self-lubricating CBN abrasive composites is evaluated in terms of the friction coefficient and morphologies of the ball and scratches after rotating sliding tests.
Commentary: transformative service research and social marketing – converging pathways to social change
Authors: Russell-Bennett Rebekah , Fisk Raymond P. , Rosenbaum Mark S. , Zainuddin Nadia 
Published: July 2019

Purpose
The purpose of this paper is to discuss two parallel but distinct subfields of marketing that share common interests (enhancing consumers’ lives and improving well-being): social marketing and transformative service research. The authors also suggest a research agenda.

Design/methodology/approach
The paper offers a conceptual approach and research agenda by comparing and contrasting the two marketing fields of transformative service research and social marketing.

Findings
Specifically, this paper proposes three opportunities to propel both fields forward: 1) breaking boundaries that inhibit research progress, which includes collaboration between public, private and nonprofit sectors to improve well-being; 2) adopting more customer-oriented approaches that go beyond the organizational and individual levels; and 3) taking a non-linear approach to theory development that innovates and co-creates solutions.

Originality/value
This paper presents the challenges and structural barriers for two subfields seeking to improve human well-being. This paper is the first to bring these subfields together and propose a way for them to move forward together.
The effect of managerial horizon on cash holdings
Authors: Guha Sanjib , Rahim Niazur 
Published: July 2019

Purpose
US corporations are now sitting on an enormous stockpile of cash. Instead of investing their resources and creating jobs, the firms are holding on to excess cash. Academicians and practitioners alike have tried to fathom the reasons why companies are holding on to so much cash. Numerous studies have talked about the various motives for holding cash. Many researchers have tried to correlate excess cash holding with particular firm characteristics. The purpose of this paper is to study the correlations that exist between excess cash holding and some measurable managerial characteristics.

Design/methodology/approach
Four different measures of managerial horizon (MH) were constructed. The first two constructs (MH1 and MH2) are based on the CEO’s age and how long he has been the CEO of the company. The next two constructs (MH3 and MH4) are based on compensation, proportion of current compensation and proportion of future compensation. This paper tries to examine if MH has any impact on excess cash holding.

Findings
The results clearly show that the CEO age and the proportion of CEO’s compensation (current and future) do determine level of cash holding in the company. Younger CEOs hold more cash compared to older CEOs. Older CEOs hold less cash suggesting that as CEOs grow older they might be motivated by the idea of leaving a long lasting legacy. CEOs who receive more of their compensation in future payments also hold on to more cash, whereas CEOs who receive more of their compensation in current payments hold less cash.

Originality/value
There is no previous literature dealing with MH and cash holding by corporations.
Telling a success story through the president’s letter
Authors: Martins Adelaide , Gomes Delfina , Oliveira Lídia , Ribeiro João Leite 
Published: July 2019

PurposeThis paper aims to explore the role of storytelling and impression management (IM) through the president’s letter in legitimizing the practices of an electricity company with regard to controversial issues during a period of change.Design/methodology/approachDrawing on a qualitative case study, this paper examines annual report letters from 1995 to 2013 using a methodological interpretative approach.FindingsBy promoting a success story using IM, the presidents give sense to particular actions related with controversial issues and attempt to influence expectations on strategic changes. The findings demonstrate that organizational actors use the flexibility of the president’s letter to tellthestory and emphasize its self-laudatory nature. The study highlights that storytelling in these documents can be used to alleviate the tensions created by the inherent contradictions of social structures.Practical implicationsThis research is useful for regulatory authorities, users of annual reports and academic researchers, making them attentive of the narratives companies may adopt to protect their legitimacy. The findings shed light on the need to evaluate the credibility of accountability mechanisms and can help stakeholders to develop a more critical view of the president’s letter.Originality/valueThis paper makes a contribution to research on communication issues by expanding literature on accounting and organizational storytelling. By demonstrating how presidents use sensegiving as a means of legitimacy-claiming, this study adds to the literature on legitimating accounts. In doing so, this paper bridges the gap between theories about organizational legitimacy, storytelling and IM. To sum up, the findings serve as an incremental step toward understanding the nature of accountability reporting.
Collective action and UK wine investment fraud
Authors: Einarsen Karina Mari Olsen , Jack Lisa 
Published: July 2019

Purpose
The purpose of this paper is to examine the measures taken by legitimate wine investment companies and enforcement agencies to counter alternative investment scams.

Design/methodology/approach
The authors interviewed wine industry and law enforcement specialists to understand the nature of wine investment fraud and the characteristics of the victims. They also drew on secondary data in the form of government agency research and media sources.

Findings
The majority of wine investment frauds are boiler room operations, using social engineering techniques to draw victims into the fraud. The authors conclude that countering wine investment fraud requires public education by government, the wine industry and the police.

Research limitations/implications
This is a small-scale study that uses interviews with experts in the industry and in law enforcement and secondary data as evidence. Despite the limitations in the number of interviews, the authors are able to comment on the social impacts of alternative investment scams and suggest a theoretical basis for future work in the field.

Practical implications
The authors make a case for regulators and investors to be part of collective action through education and public awareness campaigns to combat alternative investment fraud.

Originality/value
The authors outline how collective action theory might be extended to investigate fraud prevention measures in other financial and commodity markets.
Traits including leaf dry matter content and leaf pH dominate over forest soil pH as drivers of litter decomposition among 60 species
Authors: Tao Jianping , Zuo Juan , He Ze , Wang Yuping , Liu Jinchun , Liu Wendan , Cornelissen Johannes H. C. 
Published: July 2019

AbstractSoil pH varies by several units among ecosystems. While soil pH is known to be a key driver of plant species composition, we still have a poor understanding of how it affects carbon cycling processes. For instance, soil pH, or its associated chemistry in terms of base cations and organic acids, may affect decomposition rates of dead matter directly, by controlling decomposer composition and activity and, indirectly, by controlling the traits of the plant species and thereby the afterlife effects of those traits on litter decomposition. Leaf and litter pH may play a role in this control. Based on the very limited empirical data available, we hypothesized that variation in species traits including leaf (litter) pH, within and between ecosystems contrasting in soil pH, would have stronger effects on leaf litter decomposition rates than variation in soil chemistry would.We tested this hypothesis by carrying out a ‘common garden’ litterbed experiment in subtropical SW China, in which leaf litters of the 30 predominant plant species from mid‐successional forest on acidic sandstone (soil pH around 4.0) and calcareous soil (pH around 7.5), respectively, were incubated and their decomposition rates measured over two harvests in 14 months, both in soil plus litter matrix from their ‘home’ forest and in those from the ‘away’ forest.We found that leaf (litter) trait variation among species and plant functional types, headed by species' dry matter content but also including tissue pH, was the strongest driver of variation in leaf litter decomposition rates. Surprisingly, however, while these effects of interspecific trait variation were very strong among species from the same site, there was no overall difference in litter decomposability between the species from the acidic versus calcareous site. Equally surprising was that this strong difference in pH of soil substrate plus litter matrix from an acidic sandstone site versus a calcareous karst site did not directly affect leaf litter decomposition rates across a given species set.This first attempt to disentangle the multiple potential direct and indirect ways in which soil and leaf (litter) acidity might be related to litter decomposition rates has important implications for our understanding of soil–plant feedbacks. Based on our forest‐based study, we predict that soil–plant feedbacks via acidity are unlikely to be strong in ecosystems with wide‐ranging species in terms of their leaf functional traits, including leaf pH.A freePlain Language Summarycan be found within the Supporting Information of this article.
Diagnostic Accuracy of the Disturbed Sleep Pattern in Patients with Acute Coronary Syndrome
Authors: Prado Biani Manzoli Juliana , Dibbern Lopes Correia Marisa , Lacerda Botelho Micnéias , da Silva Begnami Natanaellin Eydiane , Pereira da Costa Paula Cristina , Marocco Duran Erika Christiane 
Published: July 2019

OBJECTIVETo clinically validate the nursing diagnosis, disturbed sleep pattern (00198), in patients with acute coronary syndrome.DATA COLLECTIONA clinical validation study using the patient history, Visual Analog Sleep scale, and diagnostic inference. Accuracy techniques were performed.SYNTHESIS OF DATAThere were 75 patients: 76.00% were men, and 82.66% had a myocardial infarction. The defining characteristic, changes in sleep pattern, presented a sensitivity of 0.900 and specificity of 0.9714.CONCLUSIONChanges in sleep pattern was a predictor of the nursing diagnosis.IMPLICATIONS FOR PRACTICEResults will contribute to the identification of sleep disturbances, by nurses, emphasizing the importance of improving sleep during hospitalization.OBJETIVOValidar clinicamente o Diagnóstico de Enfermagem Padrão de Sono Prejudicado (00198) em pacientes com Síndrome Coronariana Aguda.MÉTODOSEstudo de validação clínica, utilizando Histórico de Enfermagem, Escalas Visuais Análogas do Sono e inferência diagnóstica. Realizada medidas de acurácia.RESULTADOS75 pacientes, 76,00% homens e 82,66% com Infarto do Miocárdio. A característica definidora Alteração do Padrão de Sono teve 0,900 de Sensibilidade e 0,9714 de Especificidade.CONCLUSÕESAlteração do padrão de sono foi preditora do diagnóstico de enfermagem.IMPLICAÇÕES PARA A PRÁTICAContribuirá na identificação de distúrbios do sono, pelos enfermeiros, ressaltando a importância da melhoria do sono durante a internação.