bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are the life and death of an early‐stage venture indeed in the power of the tongue? Lessons from online crowdfunding pitches
Authors: Gafni Hadar , Marom Dan , Sade Orly 
Published: May 2018

Research Summary: While presenting initiatives to potential backers, entrepreneurs can choose the extent to which they presents themselves, versus presenting the idea. We investigate this decision and its effect on the success of fund‐raising on a leading crowdfunding platform (Kickstarter). We employ a textual quantification method validated by robustness tests. Our dataset was collected using custom software and includes more than 20,000 online business pitches and their results. We find that in Kickstarter fund‐raising, entrepreneurs’ descriptions matter—projects (especially art related) that frequently mentioned entrepreneurs’ names experienced higher rates of success, controlling for relevant variables.Managerial Summary: Many entrepreneurs are interested in learning how to deliver successful fund‐raising pitches on crowdfunding platforms. We investigate the decision to mention frequently the entrepreneur's name and its effect on the success of fund‐raising on a leading crowdfunding platform (Kickstarter). We collected information about 20,000 online business pitches and their results. We find that in Kickstarter fund‐raising, entrepreneurs' descriptions matter—projects (especially art related) that frequently mentioned entrepreneurs' names experienced higher rates of success. We conducted an experiment that indicated that projects whose entrepreneurs mentioned themselves more substantially were associated with higher levels of trust and higher levels of perceived knowledge of the entrepreneurs.
Recent Progress in Some Amorphous Materials for Supercapacitors
Authors: Li Qing , Xu Yuxia , Zheng Shasha , Guo Xiaotian , Xue Huaiguo , Pang Huan 
Published: May 2018

AbstractA breakthrough in technologies having “green” and sustainable energy storage conversion is urgent, and supercapacitors play a crucial role in this area of research. Owing to their unique porous structure, amorphous materials are considered one of the best active materials for high‐performance supercapacitors due to their high specific capacity, excellent cycling stability, and fast charging rate. This Review summarizes the synthesis of amorphous materials (transition metal oxides, carbon‐based materials, transition metal sulfides, phosphates, hydroxides, and their complexes) to highlight their electrochemical performance in supercapacitors.
Reduction of Fibrosis and Scar Formation by Partial Reprogramming In Vivo
Authors: Doeser Markus C. , Schöler Hans R. , Wu Guangming 
Published: May 2018

Abstract
Transient expression of the transcription factors OCT4, SOX2, KLF4, and C-MYC (OSKM) to induce partial reprogramming while avoiding the pluripotent state and teratoma formation has recently been discussed as a strategy for regenerating damaged tissues in vivo, whereby the impact of partial reprogramming on tissue repair remains to be elucidated. Here, we activated OSKM transcription factors in cutaneous wounds of OSKM-inducible transgenic mice and found that induction of OSKM factors in excisional wounds caused a diminished fibroblast transdifferentiation to myofibroblasts and wound contraction. Gene expression analyses showed downregulation of the profibrotic marker genes transforming growth factor beta 1, Collagen I, and vascular endothelial growth factor. Consequently, histological analyses demonstrated that OSKM induction in incisional wounds resulted in reduced scar tissue formation. These data provide proof of concept that OSKM-mediated partial reprogramming in situ can diminish fibrosis and improve tissue healing with less scar formation without the risk of tumor formation. This new insight into the effects of partial reprogramming in vivo may be relevant for developing reprogramming-based regenerative therapies for tissue injury and fibrotic diseases.
Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose-Derived Stromal/Stem Cell Therapies
Authors: Bateman Marjorie E. , Strong Amy L. , Gimble Jeffrey M. , Bunnell Bruce A. 
Published: May 2018

Abstract
The objective of this Review is to describe the safety and efficacy of adipose stem/stromal cells (ASC) and stromal vascular fraction (SVF) in treating common diseases and the next steps in research that must occur prior to clinical use. Pubmed, Ovid Medline, Embase, Web of Science, and the Cochrane Library were searched for articles about use of SVF or ASC for disease therapy published between 2012 and 2017. One meta-analysis, 2 randomized controlled trials, and 16 case series were included, representing 844 human patients. Sixty-nine studies were performed in preclinical models of disease. ASCs improved symptoms, fistula healing, remission, and recurrence rates in severe cases of inflammatory bowel disease. In osteoarthritis, ASC and SVF improved symptom-related, functional, radiographic, and histological scores. ASC and SVF were also shown to improve clinical outcomes in ischemic stroke, multiple sclerosis, myocardial ischemia, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, chronic liver failure, glioblastoma, acute kidney injury, and chronic skin wounds. These effects were primarily paracrine in nature and mediated through reduction of inflammation and promotion of tissue repair. In the majority of human studies, autologous ASC and SVF from liposuction procedures were used, minimizing the risk to recipients. Very few serious, treatment-related adverse events were reported. The main adverse event was postprocedural pain. SVF and ASC are promising therapies for a variety of human diseases, particularly for patients with severe cases refractory to current medical treatments. Further randomized controlled trials must be performed to elaborate potential safety and efficacy prior to clinical use.
Identification of the Coiled-Coil Domain as an Essential Methyl-CpG-Binding Domain Protein 3 Element for Preserving Lineage Commitment Potential of Embryonic Stem Cells
Authors: Hirasaki Masataka , Ueda Atsushi , Asaka Masamitsu N. , Uranishi Kousuke , Suzuki Ayumu , Kohda Masakazu , Mizuno Yosuke , Okazaki Yasushi , Nishimoto Masazumi , Sharif Jafar , Koseki Haruhiko , Okuda Akihiko 
Published: May 2018

Abstract
Embryonic stem cells (ESCs) exhibit two salient features beneficial for regenerative medicine: unlimited self-renewal and pluripotency. Methyl-CpG-binding domain protein 3 (Mbd3), a scaffolding component of the nucleosome remodeling deacetylase complex, is a specific regulator of pluripotency, as ESCs lacking Mbd3 are defective for lineage commitment potential but retain normal self-renewal properties. However, functional similarities and dissimilarities among the three Mbd3 isoforms (a, b, and c) have not been intensively explored. Herein, we demonstrated that Mbd3c, which lacks an entire portion of the MBD domain, exerted equivalent activity for counteracting the defective lineage commitment potential of Mbd3-knockout ESCs. Our analyses also revealed that the coiled-coil domain common to all three MBD3 isoforms, but not the MBD domain, plays a crucial role in this activity. Mechanistically, our data demonstrate that the activity of the coiled-coil domain is exerted, at least in part, through recruitment of polycomb repressive complex 2 to a subset of genes linked to development and organogenesis, thus establishing stable transcriptional repression.
Perceptions and Actions of Commercial Fishers in Response to Conservation Measures in Canadian Pacific Salmon Fisheries
Authors: Watson Maryann S. , Cook Katrina V. , Young Nathan , Hinch Scott G. 
Published: May 2018

AbstractIn Canadian Pacific salmon Oncorhynchus spp. commercial fisheries, a policy of selective fishing includes a mandatory release program intended to reduce impacts on vulnerable populations. However, there remain concerns of noncompliance with these regulations, potentially resulting in higher mortality of released fish than is accounted for. Though estimations of postrelease mortality have improved the management of commercial fisheries, the influence of fishers’ behavior is not directly considered by the regulatory framework. Additionally, perceptions of the selective fishing strategy have not been evaluated among fishers, despite knowledge that their acceptance of regulations is critical to successful management outcomes. We conducted 21 semistructured interviews with fishers from the commercial purse seine fleet for Pacific salmon about their perceptions of selective fishing, and found that attitudes towards regulations and managers are a primary determinant of compliance. We also found that greater incentives for selective fishing practices and improved communication among the fishing, management, and scientific communities would likely enhance support for management systems among members of the purse seine fleet.
Relationship Between Visceral Obesity and Postoperative Inflammatory Response Following Minimally Invasive Esophagectomy
Authors: Okamura Akihiko , Watanabe Masayuki , Fukudome Ian , Yamashita Kotaro , Yuda Masami , Hayami Masaru , Imamura Yu , Mine Shinji 
Published: May 2018

AbstractBackgroundEsophagectomy for esophageal cancer is one of the most invasive surgeries. However, the factors influencing postoperative systemic inflammatory response following esophagectomy have not been elucidated. Recently, visceral fat has been shown to play an important role in both chronic and acute inflammation. In this study, we assessed the relationship between visceral obesity and postoperative inflammatory response following minimally invasive esophagectomy (MIE).MethodsVisceral fat area (VFA) was measured using computed tomography in 152 patients undergoing MIE for esophageal cancer. We assessed perioperative serum C‐reactive protein (CRP) levels preoperatively and on postoperative days (PODs) 1–5 and analyzed the relationship between VFA and perioperative serum CRP levels.ResultsVFA was positively associated with preoperative serum CRP level (P < 0.001). Univariate analysis revealed that VFA was significantly associated with increased serum CRP levels on PODs 1–5 (P < 0.001 for each day), whereas multivariate analysis revealed that it was independently associated with increased serum CRP levels on PODs 1–4 (P = 0.033, 0.035, 0.001, and 0.006, respectively). Similar results were observed in patients who did not have postoperative infectious complications, such as pneumonia, anastomotic leak, and surgical site infection. VFA was not an independent risk factor for the occurrence of these postoperative infectious complications.ConclusionsVisceral obesity might be associated with chronic inflammation in patients with esophageal cancer and promote postoperative inflammatory response following MIE.
Genetics of breast cancer in African populations: a literature review
Authors: Abbad A. , Baba H. , Dehbi H. , Elmessaoudi-Idrissi M. , Elyazghi Z. , Abidi O. , Radouani F. 
Published: May 2018

Breast cancer (BC) is one of the most complex, diverse and leading cause of death in women worldwide. The present investigation aims to explore genes panel associated with BC in different African regions, and compare them to those studied worldwide.We extracted relevant information from 43 studies performed in Africa using the following criteria: case-control study, association between genetic variations and BC risk. Data were provided on mutations and polymorphisms associated with BC without fixing a specific date. Case-only studies and clinical trials were excluded.Our study revealed that the majority of African BC genetic studies remain restricted to the investigation of BRCA1 and BRCA2 genes and differences in their mutations spectrum. Therefore, it is necessary to encourage African researchers to characterize more genes involved in BC using methods generating global information such as next-generation sequencing in order to guide specific and more effective therapeutic strategies for the African community.
Cooperatives versus Corporations: Survival in the French Wine Industry
Authors: Valette Justine , Amadieu Paul , Sentis Patrick 
Published: May 2018

AbstractThis article examines the survival rates of cooperatives in the French wine industry. Traditional theory claims that cooperatives are inefficient and consequently are prone to failure, but recent literature suggests a higher resilience. Can cooperatives cope better? We find that French wine cooperatives survive longer than corporations. This result is robust in semi-parametric and parametric models, even when we control for mergers and acquisitions. The higher survival rate of wine cooperatives seems to be associated with their ability to pass changes in their business environments on to their members. (JEL Classifications: C41, G30, Q13)
Clustered networks protect cooperation against catastrophic collapse
Authors: SPENCER GWEN 
Published: May 2018

AbstractAssuming a society of conditional cooperators (or moody conditional cooperators), this computational study proposes a new perspective on the structural advantage of social network clustering. Previous work focused on how clustered structure might encourage initialoutbreaks of cooperationor defend against invasion by a few defectors. Instead, we explore the ability of a societal structure to retain cooperative norms in the face of widespread disturbances. Such disturbances may abstractly describe hardships like famine and economic recession, or the random spatial placement of a substantial numbers ofpure defectors(orround-1 defectors) among a spatially structured population of players in a laboratory game, etc.As links in tightly clustered societies are reallocated to distant contacts, we observe that a society becomes increasingly susceptible tocatastrophic cascades of defection: mutually-beneficial cooperative norms can be destroyed completely by modest shocks of defection. In contrast, networks with higher clustering coefficients can withstand larger shocks of defection before being forced to catastrophically low levels of cooperation. We observe a remarkably linearprotective effect of clusteringcoefficient that becomes active above acritical level of clustering. Notably, both the critical level and the slope of this dependence is higher for decision-rule parameterizations that correspond to highercosts of cooperation. Our modeling framework provides a simple way to reinterpret the counter-intuitive and widely cited human experiments of Suri and Watts (2011) while also affirming the classical intuition that network clustering and higher levels of cooperation should be positively associated.
Effect of the Health Tourism weight loss programme on body composition and health outcomes in healthy and excess-weight adults
Authors: Sagayama Hiroyuki , Shizuma Kayoko , Toguchi Makiko , Mizuhara Hiroji , Machida Yukiko , Yamada Yosuke , Ebine Naoyuki , Higaki Yasuki , Tanaka Hiroaki 
Published: May 2018

AbstractExcess weight loss while minimising fat-free mass (FFM) loss is important for health. Travel is a particular period at risk for weight gain and for which the effects of a short-term intensive weight loss programme have not been studied. Therefore, we studied the effect of a novel, 1-week supervised health travel programme combining high volume, low-to-moderate intensity exercise and energy intake restriction on weight, body composition and health outcomes in adults. Weight was also monitored for 12 weeks after the programme. In all, thirty-six subjects (nineteen men, seventeen women) consisting of sixteen excess-weight (BMI: 27·1 (sd1·7) kg/m2) and twenty healthy-weight (BMI: 22·3 (sd1·8) kg/m2) individuals participated. Subjects performed 1 h of slow-paced intermittent jogging three times per d and other leisure activities, whereas consuming only provided foods without water restriction. Body mass significantly decreased from pre- to post-intervention in excess-weight and healthy-weight individuals (−3·5 (sd1·5) and −3·5 (sd1·3) %, respectively;P<0·001 for both), and losses were maintained at 12 weeks post-intervention in both groups (−6·3 (sd3·8) and −1·7 (sd4·0) %, respectively;P<0·01 for both). Fat mass also significantly decreased in both groups (excess weight: −9·2 (sd4·6) %: healthy weight: −13·4 (sd9·0) %;P<0·01 for both), whereas FFM was maintained. Similar improvements were observed for blood biochemistry and pressure in both groups. This short-term weight loss intervention yielded favourable outcomes in both excess- and healthy-weight adults, particularly a 3·5 % weight loss with no significant change to FFM. In addition, participants maintained weight loss for at least 12 weeks. Of multiple programme choices, the Health Tourism weight loss programme’s results indicate that it is a viable option.
Fruit and vegetable consumption and risk of depression: accumulative evidence from an updated systematic review and meta-analysis of epidemiological studies
Authors: Saghafian Faezeh , Malmir Hanieh , Saneei Parvane , Milajerdi Alireza , Larijani Bagher , Esmaillzadeh Ahmad 
Published: May 2018

AbstractFindings from observational studies investigating the association between fruit and vegetable consumption and risk of depression were inconsistent. We conducted a systematic review and meta-analysis to summarise available data on the association between fruit and vegetable intake and depression. A systematic literature search of relevant reports published in Medline/PubMed, ISI (Web of Science), SCOPUS and Google Scholar until Oct 2017 was conducted. Data from 27 publications (sixteen cross-sectional, nine cohort and two case–control studies) on fruit, vegetables and/or total fruit and vegetable consumption in relation to depression were included in the systematic review. A total of eighteen studies that reported relative risks (RR), hazard ratios or OR for the relationship were included in the meta-analysis. The pooled RR for depression in the highest v. the lowest category of fruit intake was 0·83 (95 % CI 0·71, 0·98) in cohort studies and 0·76 (95 % CI 0·63, 0·92) in cross-sectional studies. Consumption of vegetables was also associated with a 14 % lower risk of depression (overall RR=0·86; 95 % CI 0·75, 0·98) in cohort studies and a 25 % lower risk of depression (overall RR=0·75; 95 % CI 0·62, 0·91) in cross-sectional studies. Moreover, an inverse significant association was observed between intake of total fruit and vegetables and risk of depression (overall RR=0·80; 95 % CI 0·65, 0·98) in cross-sectional studies. In a non-linear dose–response association, we failed to find any significant association between fruit or vegetable intake and risk of depression (fruit (cross-sectional studies): Pnon-linearty=0·12; vegetables (cross-sectional studies): Pnon-linearty<0·001; (cohort studies) Pnon-linearty=0·97). Meta-regression of included observational studies revealed an inverse linear association between fruit or vegetable intake and risk of depression, such that every 100-g increased intake of fruit was associated with a 3 % reduced risk of depression in cohort studies (RR=0·97; 95 % CI 0·95, 0·99). With regard to vegetable consumption, every 100-g increase in intake was associated with a 3 % reduced risk of depression in cohort studies (RR=0·97; 95 % CI 0·95, 0·98) and 5 % reduced odds in cross-sectional studies (RR=0·95; 95 % CI 0·91, 0·98). This meta-analysis of observational studies provides further evidence that fruit and vegetable intake was protectively associated with depression. This finding supports the current recommendation of increasing fruit and vegetable intake to improve mental health.
Inulin supplementation reduces the negative effect of a high-fat diet rich in SFA on bone health of growing pigs
Authors: Sobol Monika , Raj Stanisława , Skiba Grzegorz 
Published: May 2018

AbstractConsumption of a high-fat diet, rich in SFA, causes deterioration of bone properties. Some studies suggest that feeding inulin to animals may increase mineral absorption and positively affect bone quality; however, these studies have been carried out only on rodents fed a standard diet. The primary objective of this study was to determine the effect of inulin on bone health of pigs (using it as an animal model for humans) fed a high-fat diet rich in SFA, having an unbalanced ratio of lysine:metabolisable energy. It was hypothesised that inulin reduces the negative effects of such a diet on bone health. At 50 d of age, twenty-one pigs were randomly allotted to three groups: the control (C) group fed a standard diet, and two experimental (T and TI) groups fed a high-fat diet rich in SFA. Moreover, TI pigs consumed an extra inulin supply (7 % of daily feed intake). After 10 weeks, whole-body bone mineral content (P=0·0054) and bone mineral density (P=0·0322) were higher in pigs of groups TI and C compared with those of group T. Femur bone mineral density was highest in pigs in group C, lower in group TI and lowest in group T (P=0·001). Femurs of pigs in groups TI and C had similar, but higher, maximum strength compared with femurs of pigs in group T (P=0·0082). In conclusion, consumption of a high-fat diet rich in SFA adversely affected bone health, but inulin supplementation in such a diet diminishes this negative effect.
Role of pressure solution in the formation of bedding-parallel calcite veins in an immature shale (Cretaceous, southern UK)
Authors: MENG QINGFENG , HOOKER JOHN , CARTWRIGHT JOE 
Published: May 2018

AbstractBedding-parallel fibrous calcite veins in black shales (Cretaceous, southern UK) were investigated using a combined field, stable isotopic geochemistry, petrographic and crystallographic method to examine their formation mechanism. Calcite veins occur in all shale beds and are most abundant in the bituminous shales of the Chief Beef Beds. The calcite fibres in these veins exhibit either an antitaxial fibre growth with curvy stylolites as the median zone, or a predominantly syntaxial, upwards growth. The calcite veins range from –0.49 to 1.78‰ of δ13C values, and –6.53 to –0.03‰ of δ18O values, which are both similar to those of their host shales. Our petrographic observations demonstrate that subhorizontal and interconnecting microstylolite networks commonly occur within the calcite veins. Equant calcite grains in the median zones exhibit indenting, truncating and also interpenetrating grain contacts. It is interpreted that the fibrous calcite veins were sourced by neomorphic calcite from their host shales, with evidence from the δ13C signatures, pressure-solution features (stylolites, microstylolites and grain contact styles) and embedded fossil ghosts within the veins. The diagenetic fluids, from which calcite was precipitated, were a mixing of the original seawaters and18O-depleted meteoric waters. Development of bedding-parallel calcite veins is considered to have been enhanced by pressure solution as a positive feedback mechanism, which was facilitated by the overburden pressure as the maximum principal stress. Calcite fibres, with a predominant subvertical c-axis orientation, exhibit a displacive growth in porous shales and a replacive growth at vein-limestone contacts. This study highlights the critical role of pressure solution in the formation of bedding-parallel calcite veins during burial and diagenesis of immature black shales.