bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic polymorphism of CYP3A4 is associated
with poor response to ifosfamide treatment in children
with solid embryonic tumors
Authors: Espindola Luz María Torres , Castillejos López Manuel De JesÚs , De Uña Flores Armando , Espinosa Liliana Rivera , Granados Julio , Chávez Pacheco Juan Luis , García Martín Pérez , Ramos Cervantes Ma Teresa , Bekker Méndez Vilma Carolina , Hernández Doño Susana , Gómez Daniela Ruíz 
Published: August 2019

IntroductionThe CYP450 complex participates in the metabolism of ifosfamide, an antineoplastic drug used to treat solid tumors. genes contain several single nucleotide polymorphisms (SNPs) that confer different activity towards the enzyme. The aim of our study was to analyze gene frequencies of allelic variants and their association with ifosfamide blood levels and patient prognosis.Material and methods148 DNA samples from children were analyzed. Genotyping was performed by real-time PCR with TaqMan probes and ifosfamide levels were determined in dried blood drop by UPLCMS/MS.ResultsIfosfamide levels increased according to the genotype, and patients with the variant rs1799853 in CYP2C9 genotype CC had lower levels of ifosfamide (median = 1.8 µmol/l, Q25 0.9–Q75 4.6) compared with patients with genotype TT + CT (median = 2.8 µmol/l, Q25 1.9–Q75 5.1), p < 0.001. In the case of the rs2740574 variant in the CYP3A4 gene, patients with normal genotype (TT) presented median = 1.4 µmol/l, (Q25 0.7–Q75 2.7), while patients with the CC + TC genotype had higher levels of ifosfamide (median = 2.0 µmol/l, Q25 1.0–Q75 4.3), p = 0.024. In addition, patients with CC + CT genotype of this variant had a higher risk of non-response to treatment compared to patients with TT genotype (RR = 1.3, 95% CI: 1.07–1.59, p = 0.03).ConclusionsPolymorphisms in CYP2C9 and CYP3A4 genes are associated with high levels of ifosfamide. In addition, the polymorphism rs2740574 in CYP3A4 was associated with a worse therapeutic response.
The competitive activity structure of highly skilled basketball players on the basis of factor analysis methods
Authors: Doroshenko Edward , Sushko Ruslana , Koryahin Victor , Pityn Maryan , Tkalich Iaroslav , Blavt Oksana 
Published: August 2019

PurposeTo analyse and generalize the competitive activity structure on the basis of the hierarchy of technical and tactical indicators of qualified basketball players in won and lost games by using the factor analysis methods.MethodsThe study involved 96 professional basketball players who were national team players of countries that took 1–8 places in the final tournament of the European Basketball Championship 2017. Technical and tactical indicators of their competitive activity were analysed for revealing and interpreting the results with the factor analysis methods.ResultsThe grouping of elements of the competitive activity structure of highly skilled basketball players was analysed. Groups with the highest value of factor capacity depending on the results of the game were determined. A significant difference in the structure of technical and tactical activity in the won and lost games was presented.ConclusionsThe data obtained in the course of the study on the basis of factor analysis allowed us to present updated information
on the competitive activity structure of highly skilled basketball players and to partially confirm the existing data.
Walking biomechanics and energetics of individuals with a visual impairment: a preliminary report
Authors: Bennett Hunter J. , Valenzuela Kevin A. , Fleenor Kristina , Morrison Steven , Haegele Justin A. 
Published: August 2019

PurposeAlthough walking gait in sighted populations is well researched, few studies have investigated persons with visual impairments (VIs). Given the lack of physical activity in people with VIs, it is possible that reduced efficiency in walking could adversely affect activity. The purposes of this preliminary study were to (1) examine the biomechanics and energetics utilized during independent and guided walking in subjects with VIs, and (2) compare gait biomechanics between people with VIs and sighted controls.MethodsThree-dimensional motion capture and force platforms were used during independent and guided walking at self-selected speeds. Joint angles, moments, external work, and recovery were compared.ResultsThe VI group performed independent walking slower and with reduced stride lengths compared with guided walking and sighted controls. Hip range of motion and peak joint moments were reduced during independent walking in the VI group compared with guided walking and controls. Work was greater by 114%, 32%, and 16% in the VI group during independent than during guided walking. Recovery was 11% greater in guided vs. independent walking.ConclusionsIn the presented preliminary study among 3 persons with congenital VIs, independent walking was a less efficient mode of walking compared with guided walking and that of sighted controls.
Load-resistance analysis: an alternative approach to tsunami damage assessment applied to the 2011 Great East Japan tsunami
Authors: Suppasri Anawat , Pakoksung Kwanchai , Charvet Ingrid , Chua Constance Ting , Takahashi Noriyuki , Ornthammarath Teraphan , Latcharote Panon , Leelawat Natt , Imamura Fumihiko 
Published: August 2019

Abstract. Tsunami fragility functions describe the probability of structural damage due to tsunami flow characteristics. Fragility functions developed from past
tsunami events (e.g., the 2004 Indian Ocean tsunami) are often applied directly,
without modification, to other areas at risk of tsunami for the purpose of
damage and loss estimations. Consequentially, estimates carry uncertainty
due to disparities in construction standards and coastal morphology between
the specific region for which the fragility functions were originally
derived and the region where they are being used. The main objective of
this study is to provide an alternative approach to assessing tsunami
damage, especially for buildings in regions where previously developed
fragility functions do not exist. A damage assessment model is proposed in
this study, where load-resistance analysis is performed for each building by evaluating hydrodynamic forces, buoyancies and debris impacts and comparing them to the resistance forces of each building. Numerical simulation was performed in this study to reproduce the 2011 Great East Japan tsunami in Ishinomaki, which is chosen as a study site. Flow depths and velocities were calculated for approximately 20 000 wooden buildings in Ishinomaki. Similarly, resistance forces (lateral and vertical) are estimated for each of these buildings. The buildings are then evaluated for their potential of collapsing. Results from this study reflect a higher accuracy in predicting building collapse when using the proposed load-resistance analysis, as compared to previously developed fragility functions in the same study area. Damage is also observed to have likely occurred before flow depth and velocity reach maximum values. With the above considerations, the proposed damage model might well be an alternative for building damage assessments in areas that have yet to be affected by modern tsunami events.
The Patient-Pathologist Consultation Program: A Mixed-Methods Study of Interest and Motivations in Cancer Patients
Authors: Lapedis Cathryn J. , Horowitz Jennifer K. , Brown Lisa , Tolle Brian E. , Smith Lauren B. , Owens Scott R. 
Published: August 2019

Context.—
There is a wide disconnect between patients and the pathologists who make their diagnoses. Recent literature highlights successful programs in which patients meet with pathologists to review their pathology reports and see their tissue under a microscope. We do not know how many patients are interested in such a service, nor do we understand what drives interested patients to want to meet with their pathologist and what specific value it may provide.

Objective.—
To quantify patient interest in a patient-pathologist consultation program and qualitatively assess motivations for patient interest or disinterest.

Design.—
Subjects were recruited from an academic cancer center and a local community cancer support group to respond to a survey about their interest in a patient-pathologist consultation program. Both online forms and paper surveys were available. The online survey was promoted via social media.

Results.—
There was a high level of patient interest, with 75% of respondents indicating they were definitely interested in a patient-pathologist consultation program. Key themes of interest were enhanced understanding of the diagnosis and disease, an opportunity to demystify the diagnostic process, and the perception that additional knowledge would empower the patient.

Conclusions.—
In a select group of cancer patients, there is a very high level of interest in a patient-pathologist consultation program. Pathologists, clinicians, and hospital leadership should work together to pilot these programs in diverse settings. Additional quantitative work to scale interventions for the interested population and qualitative work to design effective, patient-centered consultation programs and to assess value are needed.
Phytosociology of the arboreal component in an area of Spring, Pernambuco
Authors: Silva Roseane Karla Soares da , Feliciano Ana Lícia Patriota , Marngon Luiz Carlos , Lima Rosival Barros de Andrade , Freire Fernando José 
Published: August 2019

This study aimed to know the phytosociological composition of the arboreal component in an area of spring in Sirinhaém - PE. Ten plots (10 m x 25 m) were arranged in rays above the springs and distributed systematically in 5 lines, separated by a 45° angle, each. In each line, 2 plots were allocated, at an interdistance of 25 m. In each plot, all individuals with CAP ≥ 15 cm were sampled, which were measured and had the estimated height. The phytosociological parameters were analyzed and an admissible sampling error of 20% and probability level of 95% was adopted. The calculated sampling error was 18%, lower than that established. The spring had a density of 1,236 individuals ha-1, with an estimated basal area of 27,647 m2 ha-1. Tapirira guianensis was characterized by a combination of large numbers of individuals, high dominance and high frequency, demonstrating that it is a species with wide distribution in the area. Regarding the relative frequency, in addition to T. guianensis, Eschweilera ovata and Inga flagelliformis were distinguished. The highest values of absolute dominance were of the species T. guianensis and Virola gardneri. In terms of Importance Value, the highlight was on T. guianensis and V. gardneri.
Comparação de modelos de regressão entre variáveis quantitativas e categóricas nos estudos de qualidade de vida de idosos
Authors: Espinosa Mariano Martinez , Oliveira Nathany Luzia de , Rodrigues Dayane de Carvalho , Alves Bryan Mariano Martínez , Marcon Samira Reschetti 
Published: August 2019

O objetivo do presente estudo foi avaliar o efeito das variáveis socioeconômicas, aspectos de saúde e dos domínios do WHOQOL-BREF e WHOQOL-OLD na qualidade de vida global dos idosos por meio de dois modelos estatísticos: regressão linear múltiplo quantitativo e regressão de Poisson múltiplo categórico. Geralmente em estudos de qualidade de vida é aplicado o modelo de regressão linear múltiplo quantitativo, no entanto os escores desta variável frequentemente não seguem um comportamento linear, mesmo realizando uma transformação dos dados da variável resposta, conforme foi verificado no presente estudo, indicando que o modelo de regressão quantitativo não foi adequado aos dados considerados. Nesta situação e também considerando que este estudo é transversal, uma alternativa foi aplicação do modelo de regressão de Poisson múltiplo com os escores da variável dependente categorizados. Neste estudo, apenas o modelo Poisson múltiplo foi adequado aos dados e com ele foi constatado que as variáveis que conjuntamente apresentaram maiores riscos na qualidade de vida foram: percepção de saúde doente, não realiza caminhada e escores dos domínios físico e psicológico; menor que a mediana.
Potabilidade da água de poços artesianos: diagnóstico de amostras dos municípios do Rio Grande do Sul
Authors: Peixoto Sandra Cadore , Merlugo Carolina Denardi , Maciel Anderson , Solner Tiago Barboza 
Published: August 2019

A água potável é toda água própria para consumo. Deve ter certa quantidade de sais minerais dissolvido, estar livre de materiais tóxicos e micro-organismos. É considerada um recurso indispensável ao homem. Um dos principais problemas está relacionado à contaminação da água, ou seja, este recurso vem sendo poluído de tal maneira que já não se pode consumi-lo em seu estado natural. Contudo, apesar de todos os esforços para armazenar e diminuir seu consumo, está se tornando um bem escasso e sua qualidade se deteriora cada vez mais rápido. Dessa forma, as águas subterrâneas vêm se constituindo como uma importante alternativa para abastecimento hídrico de comunidades. Considerando a relevância deste tema, este estudo busca fazer um diagnóstico da qualidade da água de poços artesianos da Região Central do Estado do Rio Grande do Sul, a fim de comprovar a potabilidade perante aos parâmetros da legislação vigente. Para isto os procedimentos experimentais realizados foram: determinação do valor de pH; turbidez; temperatura; sólidos totais dissolvidos; cor; dureza e concentração residual de ferro. A avaliação dos resultados obtidos neste estudo foi baseada nos padrões de potabilidade estabelecidos na Portaria nº 518, de 25 de março de 2004, do Ministério da Saúde.
Crime au féminin dans le roman africain francophone : l’exemple de Kouty, mémoire de sang d’Aïda Mady Diallo
Authors: Togola Adama 
Published: August 2019

Cet article propose une lecture du crime au féminin dans le roman africain contemporain à partir de l’ouvrage de Chrystèle Bellard sur la criminalité féminine et de travaux sur la vengeance. Il prend appui sur le roman Kouty, mémoire de sang d’Aïda Mady Diallo. Si le crime au féminin est assez rare dans la littérature francophone d’Afrique, l’on observe, avec ce roman de Diallo, une écriture qui mêle récit historique, mémoriel et policier. En effet, ce roman propose une expérience particulière de l’écriture policière qui relève d’une vision singularisée de l’individu confronté aux violences et au désir de vengeance. Nous montrerons que, dans Kouty, mémoire de sang, cette vengeance fondatrice permet non seulement de confronter les valeurs : tolérance et intolérance, et amour et haine, mais soumet aussi la démarche de Kouty aux souvenirs tragiques de la disparition de ses parents.
The Unexpected Survival of Employer Collective Action in the United Kingdom
Authors: Demougin Philippe , Gooberman Leon , Hauptmeier Marco 
Published: August 2019

Recent research within employment relations has identified how employer collective organizations continue to thrive in countries featuring different institutional characteristics. In the UK, we identify 447 membership-based Employer Organizations (EOs) active within employment relations and human resource management. The volume of organizations identified prompts our research question: what explains the changing role and activities of UK EOs?Country-level studies of EOs continuation use a range of theoretical frameworks to analyze how these organizations have adapted to institutional and economic change, but the most effective mode of analysis is debated. Our contribution is to apply Schmitter and Streeck’s identification of logics driving the behaviour of employer collective organizations, previously applied to coordinated market economies as defined by the Varieties of Capitalism framework, to the UK’s liberal market economy. The article explores the extent to which liberalization prompted new behaviour within UK EOs.Some studies argue that EOs in coordinated market economies adapt by prioritizing logics driving influence over those linked to membership. We explore how the UK’s changing political economy spurred evolution in the application of logics and find that the opposite happened. EOs once used participation within collective bargaining agreements and the governance of tripartite bodies to prioritize the logic of influence but these institutions decayed. It might have been expected that such decay would have caused a withering of EOs but they reconstituted themselves instead. The declining salience of the logic of influence prompted employer bodies to focus to a greater degree on the logic of membership by offering a broader range of member-focused services. Our findings indicate that employer collective bodies can react to liberalization with adaptation, not extinction. We also argue that our methodology could shed light on EOs behaviour in North America.
Bandwidth analysis of AC magnetic field sensing based on electronic spin double-resonance of nitrogen-vacancy centers in diamond
Authors: Yamaguchi Tatsuma , Matsuzaki Yuichiro , Saito Shiro , Saijo Soya , Watanabe Hideyuki , Mizuochi Norikazu , Ishi-Hayase Junko 
Published: August 2019

Abstract
We have recently demonstrated an AC magnetic field sensing scheme using a simple continuous-wave optically detected magnetic resonance of nitrogen-vacancy centers in diamond. This scheme is based on electronic spin double-resonance excited by continuous microwave and radiofrequency (RF) fields. Here, we measure and analyze the double-resonance spectrum and magnetic field sensitivity for various microwave and RF frequencies. We observe a clear anticrossing of RF-dressed electronic spin states in the spectrum and estimate the bandwidth to be approximately 5 MHz at a center frequency of 9.9 MHz.
Pattern of Antenatal Care Services Utilization in a Mission Hospital in Ogbomoso South-west Nigeria
Authors: Awotunde Olufemi Timothy , Amole Isaac Olusayo , Adesina Stephen Adesope , Adeniran Adenike , OlaOlorun David Akintayo , Durodola Adewumi Ojeniyi , Awotunde Titilope Abisola 
Published: August 2019

Aim: To examine the pattern of antenatal care services (ANC) utilization in Baptist Medical Centre, Ogbomoso, a mission hospital with a focus on individual, family, religious and socio-economic factors affecting ANC utilisation.
Study Design: The study was a cross-sectional prospective study.
Place and duration of the study: The study was conducted among antenatal care seekers who attended antenatal care at the Baptist Medical Centre, Ogbomoso (now Bowen University Teaching Hospital) between August 1, 2002 and May 31, 2003.
Methodology: The pretested questionnaire was used to obtain the following information: sociodemographic characteristics, family type, parity and booking gestational age in weeks. Analysis was done using SPSS 16. Proportions were determined and statistics presented in tables. Chi-square test was done to determine the association between variables.
Results: A total of 442 pregnant women were recruited for the study. The age range of attendees was 13 – 48 years with a mean age of 29.2±5.3. Maternity service use was associated significantly with ANC attendance. Other factors associated with antenatal care attendance included: University educational status (p < .001), civil servant (p < .001) christianity (p = 0.006), residing in Ogbomoso (p < .001), class 1 social status (p < .001) and being told by doctor (p = 0.033).
Conclusion: The study unveiled educational status, occupation, social status, place of domicile, religion and need for maternity service use as factors positively associated with ANC utilization in the Baptist Medical Centre Ogbomoso.
3D Ordered Macroporous VO2 Thin Films with an Efficient Thermochromic Modulation Capability for Advanced Smart Windows
Authors: Zhuang Bainiu , Dai Zhengfei , Pang Shaofang , Xu Huiyan , Sun Lan , Ma Fei 
Published: August 2019

AbstractThermochromic smart windows can provide innovative energy savings via intelligently modulating the transmittance of indoor solar radiation to reduce the energy consumption of air conditioning in buildings. Vanadium dioxide (VO2) has desirable thermochromic properties and great prospects in smart windows. Herein, 3D ordered macroporous (3DOM) VO2 films are prepared via a sacrificial colloid template method. The as‐fabricated 3DOM VO2 films exhibit a pure monoclinic phase with a uniform layout, controllable thickness and domain sizes, and excellent optical properties. Compared to a nontemplated film, the 3DOM structured VO2 exhibits improved thermochromic performance with a high solar modulation ability (ΔTsol) of 10.8% and an ultrahigh visible transmittance (Tvis) of 71.1%. In the near‐infrared region, a large contrast transmittance of 59.5% at 2500 nm is obtained for the 3DOM VO2 film. Such excellent optical properties arising from the 3DOM structure are also demonstrated by finite element analysis. This work offers a promising way to manipulate the optical properties of a VO2 thermochromic film via structural engineering for the deployment of smart windows.
Controlled Multichannel Surface Plasmon Polaritons Transmission on Atomic Smooth Silver Triangular Waveguide
Authors: Zhang Tingting , Wang Chi , Chen Huan , Zhang Chengyun , Zhang Zhenglong , Fang Yurui , Zheng Hairong 
Published: August 2019

AbstractThe application of plasmonic devices is considered as one promising solution for overcoming the limitation of traditional electronic devices. The critical challenges of plasmonic transmission devices include the control accuracy of large‐scale signal transmission and energy loss reduction. The 2D plasmonic waveguide provides a good platform on surface plasmon polaritons (SPPs) multimode excitation and emission manipulation. Here, an atomic smooth triangular waveguide with controllable multichannel transmission and relative long 1/e decay length is demonstrated. Corresponding SPPs excitation and propagation process are investigated through far‐field and near‐field distributions both experimentally and numerically. It is found that two different SPPs propagation modes can be selectively excited and supported on the surface of the 2D waveguide, and the propagation path can be controlled by the interference of the SPPs modes. The collimated beams with tunable period are also achieved on this waveguide via utilizing the interference between the reflected SPPs and the SPPs propagating from the other side of the plate through the edge. This work provides high‐performance 2D plasmonic waveguides with a comprehensive analysis of surface plasmon, which may have potential applications in 2D microplate‐based integrated photonic devices.
Motile Artificial Chromatophores: Light‐Triggered Nanoparticles for Microdroplet Locomotion and Color Change
Authors: Salmon Andrew R. , Cormier Sean , Wang Wenting , Abell Chris , Baumberg Jeremy J. 
Published: August 2019

AbstractGold nanoparticles coated with a poly(N‐isopropylacrylamide) (pNIPAM) shell undergo reversible dis/assembly below and above the critical temperature of 32 °C. Loading these particles into microdroplets at high density creates light‐driven artificial chromatophores. Triggering the nanoparticle assembly gives dramatic color changes from nanoparticle localization at the base of the droplets, resembling zebrafish melanophores. These reversible chromatophore states can be switched by both bulk and optical heating, explored here in individual microdroplets and in large cm2 areas of close‐packed droplets. Illuminating chromatophores off‐center with a tightly focused beam results in droplet locomotion via two separate mechanisms, Marangoni interfacial shear and gas bubble propulsion, depending on optical power.