bluuebunny/crossref_metadata_2025_split huggingface dataset:
The TROG 15.01 stereotactic prostate adaptive radiotherapy utilizing kilovoltage intrafraction monitoring (SPARK) clinical trial database
Authors: Sengupta Chandrima , Nguyen Doan Trang , Li Yifan , Hewson Emily , Ball Helen , O'Brien Ricky , Booth Jeremy , Kipritidis John , Eade Thomas , Kneebone Andrew , Hruby George , Bromley Regina , Greer Peter , Martin Jarad , Hunter Perry , Wilton Lee , Moodie Trevor , Hayden Amy , Turner Sandra , Hardcastle Nicholas , Siva Shankar , Tai Keen‐Hun , Arumugam Sankar , Sidhom Mark , Poulsen Per , Gebski Val , Moore Alisha , Keall Paul 
Published: November 2024

AbstractPurposeThe US National Institutes of Health state that Sharing of clinical trial data has great potential to accelerate scientific progress and ultimately improve public health by generating better evidence on the safety and effectiveness of therapies for patients (https://www.ncbi.nlm.nih.gov/books/NBK285999/ accessed 2024‐01‐24.). Aligned with this initiative, the Trial Management Committee of the Trans‐Tasman Radiation Oncology Group (TROG) 15.01 Stereotactic Prostate Adaptive Radiotherapy utilizing Kilovoltage intrafraction monitoring (KIM) (SPARK) clinical trial supported the public sharing of the clinical trial data.Acquisition and Validation MethodsThe data originate from the TROG 15.01 SPARK clinical trial. The SPARK trial was a phase II prospective multi‐institutional clinical trial (NCT02397317). The aim of the SPARK clinical trial was to measure the geometric and dosimetric cancer targeting accuracy achieved with a real‐time image‐guided radiotherapy technology named KIM for 48 prostate cancer patients treated in 5 treatment sessions. During treatment, real‐time tumor translational and rotational motion were determined from x‐ray images using the KIM technology. A dose reconstruction method was used to evaluate the dose delivered to the target and organs‐at‐risk. Patient‐reported outcomes and toxicity data were monitored up to 2 years after the completion of the treatment.Data Format and Usage NotesThe dataset contains planning CT images, treatment plans, structure sets, planned and motion‐included dose‐volume histograms, intrafraction kilovoltage, and megavoltage projection images, tumor translational and rotational motion determined by KIM, tumor motion ground truth data, the linear accelerator trajectory traces, and patient treatment outcomes. The dataset is publicly hosted by the University of Sydney eScholarship Repository at https://doi.org/10.25910/qg5d‐6058.Potential ApplicationsThe 3.6 Tb dataset, with approximately 1 million patient images, could be used for a variety of applications, including the development of real‐time image‐guided methods, adaptation strategies, tumor, and normal tissue control modeling, and prostate‐specific antigen kinetics.
Diagnostic Concordance Between Physiotherapist and Emergency Physicians for Patients With a Musculoskeletal Disorder in the Emergency Department
Authors: Gagnon Rose , Perreault Kadija , Matifat Eveline , Desmeules François , Berthelot Simon , Hébert Luc J. 
Published: November 2024

ABSTRACTBackgroundMany patients present to the emergency department (ED) with a musculoskeletal disorder. In consequence, some hospitals have integrated autonomous management of musculoskeletal disorders by physiotherapists after triage. Although potential benefits were demonstrated, few studies have examined the agreement between physiotherapists' and emergency physicians' diagnosis. A better understanding of diagnostic concordance between physiotherapists and emergency physicians could inform the implementation of this care model.Methods and FindingsSecondary analysis of data obtained through a pilot pragmatic randomised clinical trial. Data from patients presenting a minor musculoskeletal disorder managed by a physiotherapist and an emergency physician were used. Diagnostic concordance was examined using raw agreement and Gwet's first‐order agreement coefficient. Thirty‐six participants were assessed by both professionals (36.8 ± 18.2 years; W: 55.6%). Overall raw agreement was 86.1% and the diagnostic concordance was almost perfect (Gwet's AC1: 0.84, 95% CI: 0.69–0.98). The most common disagreement was when physiotherapists suspected a bone fracture or contusion, whereas emergency physicians diagnosed a ligament or meniscus disorder.ConclusionsOur results show excellent diagnostic concordance between physiotherapists and emergency physicians, thus supporting the safety of physiotherapy care in the ED. More studies are needed to confirm these results with a larger variety of diagnoses and age strata.
Theoretical Investigation of Dynamic Pile–Soil Interaction in Torsion Considering Continuity of Heterogeneous Soil
Authors: Liu Xin , Tang Liuqing , Wu Wenbing , El Naggar M. Hesham , Zhang Zhiqing , Wang Haiyang , Sun Jun 
Published: November 2024

ABSTRACTThe dynamic response of a torsionally loaded pile embedded in heterogeneous soil is investigated in this paper based on a new theoretical model of the dynamic pile–soil interaction with consideration of the continuity of heterogeneous soil. By conceptualizing the surrounding soil as an elastic continuum with shear modulus following a power law variation along the depth, a new governing equation is established to portray the dynamic torsional deformation of the heterogeneous soil. With coupling of the pile motion under dynamic torque, the theoretical solution of the torsional dynamic impedance of an end‐bearing pile embedded in heterogeneous soil is obtained by employing analytical techniques. Comparative analyses under varied conditions are conducted to authenticate the applicability and superiority of the proposed theoretical model. Parametric studies are performed via extensive arithmetic examples to decipher the mechanism of torsional vibration of the end‐bearing pile in heterogeneous soil. Conclusively, the significant influences of soil heterogeneity along depth on the dynamic response of torsionally loaded piles are identified, and the characteristics of the cut‐off frequency of the dynamic damping are elucidated in detail. The outcomes attained herein can serve to formulate guidelines for design and facilitate the evaluation of pile performance in practical applications.
Cultural Tailoring and Implementation Science for Cardiometabolic Interventions in Asian Americans: A Systematic Review
Authors: Nguyen Angelina P. , Tadano Mamie , Im Brianna Y. , Kim Miyong T. , Nguyen Tam H. 
Published: November 2024

ABSTRACTAimThe purpose of this systematic review was to identify key factors that lead to variations in outcome in cardiometabolic interventions among Asian Americans.DesignSystematic review.Review Methods and Data SourcesIn October 2022, a systematic search was conducted in the following databases: CINAHL, Cochrane, PsycINFO, PubMed and Web of Science. Results of database searches were uploaded to Rayyan for screening of titles, abstracts and full texts. Based on inclusion and exclusion criteria, twelve studies published across seventeen articles between 2002 and 2021 were included in this review. These studies were assessed for bias using the Revised Cochrane Risk of Bias tool.ResultsCultural tailoring was an element of 91.7% of the studies. More than one‐third of the studies utilized community health workers to build relationships with the communities being studied. Overall, lifestyle interventions targeted for Asian American populations led to improvements in both physical and psychosocial outcomes such as mental health, self‐efficacy, disease knowledge, behavior change and/or quality of life.ConclusionThis systematic review of interventions targeting cardiometabolic outcomes among Asian American populations reveals many gaps in the existing literature. For one, there is limited research on the association of various sociodemographic variables with participants' success and/or retention in health intervention studies among Asian American populations. Interventions utilizing technology have also been lacking with this population and are a potential tool for improving health outcomes.Impact and ImplicationsDiabetes and cardiovascular disease are both ranked in the top five causes of Asian American deaths. The reviewed articles' findings were mixed but suggest that culturally tailored interventions aimed to improve the cardiometabolic health of Asian Americans are generally effective. As we move forward, this body of research serves as a crucial foundation for shaping the future of culturally tailored interventions, guiding nurse researchers to develop more effective strategies for treating and preventing these prevalent and cardiometabolic conditions.Reporting MethodCompleted PRISMA checklist is available upon request.No Patient or Public ContributionThis systematic review better informs future directions for person‐centred, community‐based and participatory research.
Numerical validation of an innovative 3D calculation method of high‐rise buildings under consideration of component and soil stiffness
Authors: Badr Michael , Müllner Herbert W. 
Published: November 2024

AbstractAt the end of the PORR Bau GmbH research project, which ran from 2015 to 2022 and which provided data on strain and settlement sensors from a total of four high‐rise buildings, an innovative calculation method for three‐dimensional building models was finally developed. This is based on a stiffness combination vector that can be applied independently of the finite element program and the modeling quality of the responsible structural engineer. Furthermore, the bedding modulus for supporting the floor slab is varied within the limits specified by the soil expertise by dividing the floor slab into quadrants.
Reducing the entry barrier for users and developers of peridynamic high performance computing
Authors: Hesse Jan‐Timo , Willberg Christian , Pernatii Anna 
Published: November 2024

AbstractOver the past two decades, Peridynamics (PD) research has exhibited remarkable diversity, with contributions spanning more than 180 journals and involving over 1000 researchers. Despite its broad applicability, a persistent challenge remains—how to foster widespread adoption. In the engineering domain, classical continuum mechanics, predominantly facilitated by the finite element method, enjoys extensive utilization, supported by a plethora of commercial and open‐source software tools. PD simulation tools often find themselves competing with these well‐established counterparts. In research, custom codes tailored for specific applications are frequently created and applied, with little consideration for their future reuse or third‐party utilization. The complexity is further exacerbated in High‐performance computing (HPC) applications, where a deep understanding of solvers, parallel computing, and PD is imperative for a successful software development. Given the constraints of a typical doctoral thesis, large‐scale problems are often left unexplored, and research tends to be confined to simplistic geometries. This paper aims to elucidate various pathways for the seamless integration and utilization of a PD framework. We will showcase examples that illustrate how the barriers for both users and developers can be significantly lowered, ultimately propelling PD simulation tools to a higher standard of maturity in the medium term.
Robust Dual Crosslinking Ionic Network for High‐Performance Cis‐1, 4‐Polyisoprene Latex/Sodium Alginate Composites
Authors: Guo Liyun , Zhang Haichang , Hua Jing , Liu Jinhui 
Published: November 2024

ABSTRACTExisting natural rubber latex (NRL) medical gloves are problematic due to protein allergies and poor sweat resistance. Cis‐1,4‐polyisoprene latex (IRL) is an ideal alternative of NRL for free from proteins, while its poor mechanical properties severely restrict the application as medical gloves. Here we proposed a straightforward strategy of latex compounding to incorporate sodium alginate (SA) into IRL. High‐performance IRL/SA composite films with remarkable strength and super hydrophilic properties were achieved benefiting from a dual ionic crosslinking network. The properties and the morphology of the IRL/SA composite latexes and films were investigated. Experimental results revealed that the composite latexes had a stable state, possessed good film‐forming abilities and exhibited outstanding mechanical properties. The sodium alginates were uniformly dispersed throughout the IR matrix. Compared with IRL films, the tensile strength of the IRL/SA (30 phr) composite film increased by 30.7%. Notably, the IRL films exhibited a swelling degree of 0.05%, while IRL/SA (30 phr) composite film increased to 14.5%. Moreover, swelling in PBS buffer solution has little effect on the mechanical properties of the IRL/SA composite films. Thermal oxygen aging test suggested that the tensile strength change rate exhibited a decrease of approximately 30%, closely to that of NRL. The current composite films are well‐suited for high‐end medical applications.
Pediatric Neuroendocrine Tumors in Denmark: Incidence, Management, and Outcome From 1995 to 2020
Authors: Ankerstjerne Mona P. , Giovannoni Sara , Christensen Lene G. , Möller Sören , Holmager Pernille , Knigge Ulrich , Ellebaek Mark B. , Rathe Mathias 
Published: November 2024

ABSTRACTBackgroundNeuroendocrine tumors (NETs), although rare, are considered one of the most common gastrointestinal and bronchopulmonary pediatric neoplasms. We aimed to determine the incidence, tumor characteristics, management, and outcome of NETs and explore the role of genetic predisposition, focusing on low and intermediate grade tumors.MethodsUsing the Danish National Pathology Registry, we conducted a nationwide retrospective study including all Danish children aged ≤18 years diagnosed with a pathology‐proven NET between 1995 and 2020.ResultsWe identified 220 patients, with a 1.89:1 female to male ratio. The yearly incidence was 6.84 per 1 million children, with no significant change in incidence throughout the observation period. NETs were located in the appendix (93.2%), the pulmonary system (4.5%), and pancreas (2.3%). One recurrence was noted in the pancreas in a genetically predisposed patient with multiple neuroendocrine neoplasia type 1 (MEN1), resulting in an overall recurrence rate of 0.5% (0% in appendiceal NETs; 0% in bronchopulmonary NETs; 20.0% in pancreatic NETs). No NET‐related mortality was registered. Four patients had a known predisposing genetic condition, one appendiceal NET associated with neurofibromatosis type 1, and three pancreatic NETs associated with MEN1. Postsurgical surveillance regimes, choice of tumor markers, and imaging modality varied throughout the study period.ConclusionsWe confirmed a stable incidence of pediatric NETs during the study period. The overall recurrence rate was 0.5% and no NET‐related mortality was observed. Known genetic predisposition was present in 1.8% of patients. Future guidelines should consider the apparent indolent nature and excellent prognosis of these tumors.
Research progress on laser processing of carbon fiber composite materials
Authors: Zuo Pei , Liu TongFeng , Li Fang , Wang Guoyan , Zhang Kaihu , Li Xin , Han Weina , Tian Hong , Zhu Di 
Published: November 2024

AbstractCarbon fiber reinforced polymer (CFRP) is a high‐performance composite material composed of carbon fibers embedded in a polymer matrix. CFRP is extensively used in various sectors such as aerospace, automotive, sports equipment, and construction due to its advantageous properties. Laser processing offers numerous advantages when working with carbon fiber‐reinforced composites, including its non‐contact nature, precision, efficiency, and controllability. However, disparities between carbon fibers and the polymer matrix can lead to challenges during laser processing, such as delamination, heat‐affected zones, and fiber pullout. Consequently, there is a substantial body of literature focusing on improving the quality and efficiency of laser processing for CFRP materials. This paper provides a comprehensive review of various studies investigating the impact of laser parameters (laser mode, pulse frequency, pulse width, and laser wavelength) on carbon fiber‐reinforced plastics. It discusses how different laser parameters affect the processing quality and performance of these materials. Additionally, drawing from recent research findings, the paper explores potential future trends in laser processing for carbon fiber‐reinforced plastics.Highlights
The application of laser technology in CFRP, including laser cutting, drilling, welding, and surface treatment, has been extensively researched.
A detailed discussion is held regarding the impact of laser mode, wavelength, frequency, and pulse width on the quality of machining.
More auxiliary processing has evolved in CFRP manufacturing due to the ongoing advancements in laser technology.
The goals of laser processing CFRP technology are increasingly focused on reducing carbon emissions, enhancing energy efficiency, and minimizing waste.
Analysis on the effect of sodium hydroxide treatment and graphene nano‐particle reinforcement on the shear behavior and modal analysis of glass fibre reinforced polymer flat‐joggle‐flat composite joints
Authors: Hiremath Vinayak S. , Reddy D. Mallikarjuna , Palaniappan Sathish Kumar , Mutra Rajsekhara Reddy , Siengchin Suchart , Venkatachalam Gopalan 
Published: November 2024

AbstractThe use of composite materials, particularly glass fiber‐reinforced polymers (GFRP), has considerably increased. The present investigation seeks to ascertain how sodium hydroxide (NaOH) treatments and the incorporation of graphene nano‐particulates (GNP) in GFRP flat‐joggle‐flat (FJF) composite joints. The experiments demonstrated that surface treatment with 0.1 N NaOH and the addition of 0.25, 0.50, and 0.75 wt% GNP reinforcement to the resin considerably enhanced the shear behavior of the FJF joints by 5.48%, 16.04%, and 32.77%, respectively, as compared to plain GFRP specimens, due to the improved chemical bonding and excellent IR radiation retention. 0.2 N NaOH treated with the same GNP concentrations lowered the shear strength compared to 0.1 N NaOH due to the linear reduction in fiber size. Field emission scanning electron microscopy gives a clear failure analysis of the FJF joint specimens. Fourier transform infrared spectroscopy investigation determines the chemical structure of GFRP materials based on distinctive peak intensities in the infrared range and different functional groups contained in the composite materials. Atomic force microscopy testing was done to evaluate the surface textures. The vibration analysis firm that the FJF joint having 0.1 N NaOH with 0.75 wt% of graphene had the highest natural frequency.Highlights
The effect of NaOH treatment and graphene influence on FJF joints.
Shear analysis of the FJF composite joints.
FTIR and AFM techniques were adopted to analyze the surface properties.
Modal analysis is used to evaluate the natural frequencies.
Impact of Regulatory Risk Communication on Thrombosis With Thrombocytopenia Syndrome for COVID‐19 Adenovirus Vector Vaccines on European Healthcare Professionals
Authors: van Vliet Ella , Lipovec Nanča Čebron , van der Goot Marloes , Abtahi Shahab , Ribeiro ‐Vaz Inês , Poplavska Elita , Dermiki‐Gkana Foteini , Oikonomou Chara , Deligianni Elena , Kontogiorgis Christos , Silva Ana Marta , Ferreira Paula Barão Sousa , Kos Mitja , Almarsdóttir Anna Birna , Jacobsen Ramune , Buhl Caroline , de Bruijn Adrie , Hegger Ingrid , Alves Teresa Leonardo 
Published: November 2024

ABSTRACTPurposeThe European Medicines Agency (EMA) issued regulatory actions and communications in 2021 on thrombosis with thrombocytopenia syndrome (TTS) associated with adenovirus vector vaccines Vaxzevria or Jcovden. This study aimed to evaluate the impact of these actions on awareness, knowledge and implementation in practises of healthcare professionals (HCP).MethodsWeb‐based cross‐sectional surveys were conducted on HCPs engaged in the vaccination, monitoring or counselling about the vaccines. We measured awareness and knowledge of the risk of TTS and their implementation of recommendations in practise. Descriptive and qualitative analyses were conducted. This study took place in Greece, Latvia, Netherlands, Portugal and Slovenia.ResultsWe surveyed 1659 HCPs. From these, 914 were included in the analysis. Most were aware about the reports of TTS associated with COVID‐19 adenovirus vector vaccines, with countries reporting percentages between 85% and 97%. Mainstream media, health authorities and peers were the main sources of TTS risk information. Most HCPs were able to identify key symptoms from TTS but were less familiar with minor symptoms. Guidelines from health authorities on COVID‐19 vaccination impacted on professional practise of 55%–77% of HCPs. The reported use of product information across countries was moderate, with some variations.ConclusionsAwareness about and knowledge of TTS risk from COVID‐19 adenoviral vector vaccines were high among HCPs. HCPs reported a clear preference for national guidelines as source of risk information and the implementation of product information remained moderate across countries.
What does the seawater desalination industry need from polymer scientists?
Authors: Fellows Christopher M 
Published: November 2024

AbstractThe seawater desalination industry does not need exotic two‐dimensional materials. However, it faces challenges in terms of membrane resilience to stressors such as temperature and oxidation and especially in the area of (bio)fouling. Membrane replacement is a large part of the operating expenditure of modern desalination plants and anything that increases the effective lifespan of a membrane will have economic impact. There are also emerging requirements for membrane selectivity, especially in desalination‐adjacent brine‐valorisation activities. These challenges provide abundant scope for the exercise of creativity by polymer scientists. © 2024 Society of Chemical Industry.
Out of area placements for people with “Personality Disorder”: Making the case for a local intensive psychotherapeutic alternative
Authors: Mizen Susan , Jones Vanessa , Howson Susan 
Published: November 2024

AbstractObjectivesThe use of Out of Area (OoA) psychiatric placements for people with “Personality Disorder” (PD) is widespread in the UK. An innovative local intensive psychotherapeutic service, adapted to the transdiagnostic presentations of the most complex PD patients, likely to be placed out of the area, was devised in the English County of Devon. This paper reports the findings of a Freedom of Information (FOI) request to commissioners attempting to quantify PD OoA placements in England and the cost offset of the local therapeutic alternative to OoA placements in Devon.Design and MethodsData from FOI requests was combined with publicly available sources to assess the scale of OoA placements for people with PD in England. OoA service use and cost data were used to examine the cost offset and effectiveness of the local alternative to OoA placements in Devon.The results found a lack of transparency and excessive use of OoA placements despite UK Government intentions. Data from the local therapeutic service demonstrated cost‐effectiveness, reducing OoA placements and increasing the availability of psychotherapeutic services.This paper suggests the number of OoA placements can be reduced for people with severe and complex PD. The local therapeutic service provides a model for future rehabilitation pathways.