bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clima de segurança em terapia intensiva para adultos: foco nos profissionais de enfermagem
Authors: Souza Verusca Soares de , Derenzo Neide , Costa Maria Antônia Ramos , Mendonça Renata Rodrigues , Lima Wesley Luiz Ferreira de , Matsuda Laura Misue 
Published: March 2019

Objetivo: analisar o clima de segurança em uma unidade de terapia intensiva (UTI) para adultos.Método: descritivo, de abordagem quantitativa, realizado em junho de 2014 em um hospital ensino. Participaram 13 (46,42 %) enfermeiros e 15 (53,57 %) técnicos de enfermagem, que responderam ao questionário Safety Attitudes Questionnaire(SAQ), com 36 itens, divididos em seis domínios e cinco níveis de respostas que foram consideradas adequadas se o escore total médio atingisse uma pontuação acima de 75.Resultados: obteve-se os totais médios por domínio: clima de trabalho em equipe = 77,38 pontos; clima de segurança = 69,90 pontos; satisfação no trabalho = 88,04 pontos; percepção do estresse = 67,19 pontos; percepção da gerência = 60,71 pontos e condições de trabalho = 74,11 pontos.Conclusão: o clima de segurança na UTI investigada é inadequado porque, dentre os seis domínios avaliados, quatro obtiveram pontuações menores que o estabelecido.
Effect of voluntary exercise on intracellular signalling pathways of angiogenesis in the sciatic nerve of type 1 diabetic castrated male rats
Authors: Zanjani SB , Chodari L , Bavil FM , Sadeghzadeh P , Shahabi P 
Published: March 2019

Objectives
Impaired angiogenesis in sciatic nerve is a major complication of diabetic neuropathy. Protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling pathways play critical roles during capillary-like network formation in the angiogenesis process.

Methods
Twenty-four adult male Wistar rats (weight: 250–300 g) were used in the research. The rats were randomly divided into four groups (n = 6): (1) diabetic (Dia), (2) diabetic + castration (Dia-Cas), (3) diabetic + exercise (Dia-E), and (4) diabetic + castration + exercise (Dia-Cas-E). Type 1 diabetes (T1D) was induced with streptozotocin (50 mg/kg). After 6 weeks, sciatic nerve was separated and used for histological evaluation and determination of phosphorylated AKT (P-AKT) and phosphorylated ERK (P-ERK) levels by ELISA method.

Results
Glucose levels decreased in the Dia-E group compared to the Dia-Cas group (p < 0.01). In addition, our finding shows that exercise in the Dia-Cas group diminished blood glucose levels compared to the Dia-Cas group but this effect of exercise was not significant. Voluntary exercise in the diabetic castrated group decreased P-AKT protein and increased P-ERK 1/2 protein levels in the sciatic tissue compared to the diabetes group significantly (p < 0.05). Histopathological findings showed that Dia-Cas group with 6-week exercise training significantly raised the number of microvascular density in the sciatic tissue of diabetic rats compared to the diabetic group (p < 0.05).

Conclusions
Voluntary exercise in diabetic rats increases angiogenesis in the sciatic nerve. The possible mechanism is the increase of P-ERK 1/2 but not P-AKT levels in the sciatic nerve of T1D rats.
La productividad neológica de la derivación en un léxico técnico: una mirada diacrónica.
Authors: Corveddu Mario Salvatore 
Published: March 2019

En la España de los siglos XVIII y XIX, los avances de la ciencia y de la técnica impactaron profundamente los antiguos oficios, modificando la estructura conceptual a través de una masiva introducción de nuevas nociones. A nivel lingüístico, esta situación se tradujo en una necesidad léxica cuya extensión condujo la lengua a un rápido proceso de creación neológica. El articulo pretende contribuir al conocimiento de este período de la historia de la lengua española, analizando la productividad del mecanismo lexicogenético de la derivación en un léxico técnico[1]: el curtido y adobo de cueros. Adoptando una perspectiva diacrónica, el estudio se propone dos objetivos. El primer objetivo es la descripción cuantitativa del fenómeno, observando las dinámicas neológicas en los apartados que constituyen el dominio investigado. El segundo objetivo es analizar los afijos con el fin de individuar los patrones que regularizan el recorrido a este mecanismo.[1]El estudio presenta algunos de los resultados de un trabajo más amplio de tesis doctoral donde, a partir de la reconstrucción del léxico histórico del curtido y adobo de cueros, los mecanismos neológicos han sido objeto de estudio.
Estado del arte del español como lengua extranjera (ELE) en Bogotá: cursos de ELE que nacen y se hacen
Authors: Díaz Correa Angélica María 
Published: March 2019

This article is a result of the recent increase in interest in the field of Spanish as a Foreign Language (SFL) in the city of Bogotá. For this reason, a study was carried out in order to bring the state of the art in SFL in Bogotá up to date. The research question had to do with asking about how SFL started and its development. The article includes a brief description of the universities which offer teacher education programs in the teaching and learning of SFL and an overview of the current courses offered by some universities in the city. Finally there are some considerations about the limitations and projections of SFL programs in Bogotá.
Discovery of Organosulfur Compounds as Promising Antiglycation Agents with Non-Toxic Nature Against Mouse Fibroblast 3T3 Cells
Authors: Abbas Ghulam , A Al-Harrasi , H Hussain 
Published: March 2019

Protein glycation is one of the major causes of diabetic complications while antiglycation therapy is the most important intervention to manage diabetic complications. Â Currently, sulfur-containing compounds are under extensive studies due to their vast pharmacological applications particularly, against diabetic mellitus and oxidative stress induced pathological disorders.Present study is an effort to evaluate various classes of organosulfur compounds to explore promising inhibitors against protein glycation with enhanced antiglycation potential and low toxic effects. A library of organosulfur compounds belonging to different classes was investigated for their potential inhibition against protein glycation in vitro while MTT assay on mouse fibroblast 3T3 cells was used to assess the potential cytotoxicity of most promising antiglycation agents.On antiglycation assay, eight organosulfur compounds (1-8) exhibited a potent antiglycation activity with IC50 values (<16 ÂµM), as compared to standard antiglycation agent rutin (IC50 = 98.01Â±2.03 ÂµM). Similarly, compound (9) and compound (10) exhibited good antiglycation potential with IC50 values 591.6Â±1.53 and 401Â±1.20 ÂµM, respectively. In this assay compounds (12-18) exhibited moderate antiglycation activity (47-62% inhibition) at 1mM concentration.On mouse fibroblast 3T3 cells cytotoxicity assay, all the tested compounds were found to be largely non-toxic with IC50 values (72.5-100) ÂµM. In this assay, compound (10) exhibited slight toxic nature with IC50 value 5.00Â±1.89 as compared cycloheximide which is used as a standard in this assay with IC50 value 0.3 Â± 0.089 Î¼M.Key Words: Organosulfur compounds, diabetic complications, antiglycation agents, cytotoxicity assay
Evaluation of sedative and hypnotic activities of ethanolic extract of leaves of Cleome rutidosperma DC. (Capparidaceae) in mice
Authors: Shahed-Al-Mahmud Md. 
Published: March 2019

Cleome rutidosperma DC. (Capparidaceae) traditionally used medicine for insomnia and depression management. The aim of the recent study conducted to investigate the sedative and hypnotic activities of ethanolic extract from the leaves of C. rutidosperma (EECR) in Swiss Albino mice. Neuropharmacological test on mice employed to this study sedative (open field, hole cross, hole- board and rota-rod tests) and hypnotic (thiopental sodium-induce sleeping test) activities of EECR in mice model. The acute toxicity study and phytochemical analysis of EECR also carried out. EECR exhibits significant (p<0.001) sedative effect by decreasing the number of (square and hole) crossed by mice in open field and hole cross tests as a dose-dependent (100-400mg/kg) manner. Hole-board test significantly (p<0.001) decreased the number of head dips and showed the similar effect as diazepam (1mg/kg) in a dose-dependent manner. Rota-rod test also explicit significant (p<0.001) decreased the performance time as well as increased number of falls in a dose-dependent manner. Thiopental sodium-induce sleeping test expressed that EECR significantly (p<0.001) produce shortening latency period and prolonging the sleeping time in a dose-dependent (100- 400mg/kg) manner. The experimental result indicates, C. rutidosperma containing phytochemicals that possess sedative and hypnotic activity which traditionally used as insomnia and depression management.

Keywords: Cleome rutidosperma; Capparidaceae; Sedative; Hypnotic; Phytochemicals
Phenolic Profile and Cholinesterase, Tyrosinase, Urease and Lipid Peroxidation Inhibition Potentials of Artemisia argyi from Ordu, Turkey
Authors: ÇOL AYVAZ Melek 
Published: March 2019

The present study was designed to reveal a natural resource that could cure for today’s major diseases such as Alzheimer, Parkinson and bacterial infection. Furthermore, oxidative stress resulting from lipid peroxidation is a precursor for many diseases. Therefore, anticholinesterase, antityrosinase, antiurease activities and the inhibition potential on lipid peroxidation of methanolic extract of Artemisia argyi collected from Ordu region were tested. The inhibition ratio of extract at 0.3 mg/mL concentration for asetylcholinesterase and butrylcholinesterase were calculated as 8.45 and 10.68%, respectively. IC50 values for tyrosinase and urease inhibition properties were also found as 0.505 mg/mL and 0.225 mg/mL. The all obtained values were compared with known corresponding inhibitors such as galantamine, kojic acid and thiourea. Besides these, 0.1 mg/mL of the extract prevented lipid peroxidation in the ratio of 7.19%. In the scope of this study, the phenolics of the leaves of A. argyi were also analyzed by using HPLC system and pyrogallol was identified as the major component with the 30.16 mg/kg concentration. On the other hand, benzoic acid was not detected in extract. According to obtained results, A. argyi from Ordu, has the proposed characteristics that it can be a natural resource that can be used in the field of medicine for treatment of various diseases especially Alzheimer and Parkinson, in the cosmetic industry for the elimination of skin problems and in the agricultural field in order to prevent the loss of nitrogenous components.
Pre Understanding, Effective Histori, Fusion Of Horisons Komisi Penyiaran Indonesia Daerah (KPID NTB) Terhadap Undang-Undang Penyiaran No 32 Tahun 2002 Dan P3SPS
Authors: Najamudin Najamudin 
Published: March 2019

Pre Understanding, Effective Histori, Fusion Of Horisons istilah hermeneutik sebagai dasar untuk memahami. Sedangkan KPID adalah lembaga yang otoritatif pada pengawasan penyiran di daerah yang mengacu pada UU Penyiaran 32 Tahun 2002. Hadirnya lembaga penyiaran di NTB memiliki dampak positive negative, yaitu mampu memenuhi kebutuhan informasi bagi masyrakat NTB, tapi juga menambah permasalahan, seperti perilaku kekerasan oleh anak-anak, Pelecehan seksual oleh anak-anak maupun dewasa, kata-kata kotor oleh anak-anak dan lainnya. Prilaku tersebut diilustrasikan melalui Televisi. Pada tahap implementasi kebijakan dan pemahaman KPID tentang UU Penyiaran dan P3SPS peneliti melihatnya menggunakan teori hermneutika Gadamer dan Ripley “pendekatan kepatuhan dalam impelentasi kebijakan”. Terjadinya ketidakpatuhan tersebut disebabkan oleh kebijakan tersebut hanya berlaku formalitas, atau dalam logika hermeneutika apa yang KPID lakukan baru sebatas pemahaman literal, sehingga perlu diuji dengan Pre Understanding, Effective Histori, Fusion Of Horisons.

Keywords: Pre Understanding, Effective Histori, Fusion Of Horisons, UU Penyiaran, P3SPS, KPID, Lembaga, Penyiaran
COASTAL MOSLEM’S CREATIVE ECONOMY DEVELOPMENT MODEL : CASE STUDY IN KENJERAN SURABAYA
Authors: Widiastuti Tika , Fanani Sunan , Mawardi Imron 
Published: March 2019

The aim of this study is to understand how coastal moslem’s creative economy development are. This study has used qualitative approach with study case strategy. Data collection has done by interviewing the informants i.e. Head of Kelurahan Sukolilo and Creative Industry’s stakeholder nearby Kenjeran, Surabaya. The result of this study is an appropriate model to develop coastal moslem’s socio-economics is a holistic-integrated developments. The model involved sort of stakeholders viz. fishermans, seafood crackers producers, the government, NGO’s, and universities. Keywords : Coastal Communities, Creative Economy, Kenjeran, Sosio-Economic Development
FAKTOR-FAKTOR YANG MEMPENGARUHI INTENSI PEMBELIAN KOSMETIK HALAL
Authors: Rosida Rida 
Published: March 2019

Dewasa ini, semakin banyak masyarakat yang menyadari eksistensi produk halal, terutama di kalangan konsumen Muslim. Produk halal semakin diminati mulai dari makanan, produk keuangan dan non-keuangan, hingga pariwisata dan produk kesehatan. Hal ini mendorong produsen yang bergerak di bidang makanan, kosmetik, dan produk farmasi untuk menyusun strategi dalam memasarkan produknya. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh faktor-faktor yaitu brand, price, quality dan labelling terhadap intensi pembelian kosmetik halal. Populasi dalam penelitian ini adalah muslimah yang berdomisili di Jawa Barat. Adapun teknik pengambilan sampel yang digunakan adalah purposive sampling-quota sampling dengan jumlah sampel sebanyak 106 orang. Metode yang digunakan dalam penelitian ini adalah metode kausalitas dengan pendekatan kuantitatif. Adapun teknik analisis data yang digunakan adalah regresi linier berganda. Hasilnya menunjukkan bahwa dari empat variabel independen hanya tiga variabel yang berpengaruh signifikan terhadap intensi pembelian kosmetik halal, yaitu: brand, price dan labelling. Sedangkan quality tidak berpengaruh signifikan. Adapun secara simultan semua variabel X (brand, price, quality dan labelling) berpengaruh terhadap intensi pembelian kosmetik halal.
Pengaruh Task Technology Fit, System Quality dan Information Quality terhadap User Performance: Perceived Usefulness dan Perceived Ease Of Use Sebagai Pemediasi
Authors: Permana Ida Bagus Gede Adi , Setianto Diki Putra 
Published: March 2019

Tujuan dilakukannya penelitian ini adalah untuk mengetahui pengaruh langsung atau tidak langsung system quality terhadap user performance karyawan FEB Universitas Airlangga sebagai pengguna sistem informasi cybercampus melalui kegunaan (perceived ease of use dan perceived usefulness). Penelitian ini menggunakan sampel yang berasal dari karyawan Fakultas Ekonomi Universitas Airlangga Surabaya. Pengambilan sampel untuk penelitian ini menggunakan purposive sampling yaitu teknik pengambilan sampel berdasarkan kriteria tertentu. berjumlah 58 responden. Hasil pengujian membuktikan bahwa system quality mempunyai pengaruh signifikan terhadap user performance karyawan FEB Universitas Airlangga. Perceived usefulness dan perceived ease of use belum mampu memediasi hubungan antara system quality terhadap user performance karyawan FEB Universitas Airlangga. Information quality mempunyai pengaruh signifikan terhadap user performance karyawan FEB Universitas Airlangga. Perceived usefulness dan perceived ease of use belum mampu memediasi hubungan antara information quality terhadap user performance karyawan FEB Universitas Airlangga. Task technology fit mempunyai pengaruh signifikan terhadap user performance karyawan FEB Universitas Airlangga. Perceived usefulness dan perceived ease of use belum mampu memediasi hubungan antara task technology fit terhadap user performance karyawan FEB Universitas Airlangga.
Safety and efficacy of Curcumin versus Diclofenac in Knee Osteoarthritis: a randomized open label parallel arm study
Authors: Shep Dhaneshwar , Khanwelkar Chitra , Gade Prakashchandra , Karad Satyanand 
Published: March 2019

Abstract
Background: To compare the efficacy and safety of curcumin with diclofenac in the treatment of knee osteoarthritis (OA).
Methods: In this randomized, open label, parallel, active controlled clinical study, 139 knee OA patients were randomized to receive either curcumin 500 mg (Curcugreen®) capsule thrice daily or diclofenac 50 mg tablet twice daily for 28 days. Patients underwent assessment at baseline, day 7, day 14 and day 28. Main outcome measure was severity of pain using Visual Analogue Scale (VAS) at day 14 and day 28. Knee injury and osteoarthritis outcome score (KOOS) (at day 14 and day 28), anti-flatulent effect (at day 7), anti-ulcer effect, weight lowering effect, patient and physician’s global assessment of therapy at day 28 were included as secondary outcome measures. Safety after treatment was evaluated by recording adverse events and laboratory investigation.
Results: At day 14 and day 28, patients receiving curcumin showed similar improvement in severity of pain and KOOS scale when compared to diclofenac, and the difference was not statistically significant (p > 0.05). At day 7, the patients treated with curcumin experienced significantly greater reduction in number of episodes of flatulence compared with diclofenac (p < 0.01). At day 28, weight lowering effect (p < 0.01) and anti-ulcer effect (p < 0.01) of curcumin were observed. None of the patients required H2 blockers in curcumin group and 19 patients required H2 blockers in diclofenac group (0% vs. 28%, respectively; p < 0.01). Adverse effects were significantly less in the curcumin group (13% vs. 38% in diclofenac group; p < 0.01). Patient’s and physician’s global assessment of therapy was similar in both treatment groups.
Conclusion: Curcumin has similar efficacy to diclofenac, but demonstrated better tolerance among patients with knee OA. Curcumin can be an alternative treatment option in the patients with knee OA who are intolerant to the side effects of NSAIDS.
Trial Registration: ISRCTN, ISRCTN10074826, Registered 21 November 2017 - Retrospectively registered, http://www.isrctn.com/ISRCTN10074826
Keywords: Knee osteoarthritis; Pain; Curcumin; Diclofenac; Anti-flatulent; Weight lowering; Anti-ulcer
Real-Time Foot Clearance Biofeedback to Assist Gait Rehabilitation Following Stroke: a Randomised Controlled Trial Protocol
Authors: BEGG REZAUL , Galea Mary , James Lisa , Sparrow Tony , Levinger Pazit , Khan Fary , Said Catherine 
Published: March 2019

Abstract
Background

The risk of falling is significantly higher in people with chronic stroke and it is, therefore, important to design interventions to improve mobility and decrease falls risk. Minimum Toe Clearance (MTC) is the key gait cycle event for predicting tripping-falls because it occurs mid-swing during the walking cycle where forward velocity of the foot is maximum.

High forward velocity coupled with low MTC increases the probability of unanticipated foot-ground contacts. Training procedures to increase toe-ground clearance (MTC) have potential, therefore, as a falls prevention intervention. The aim of this project is to determine whether augmented sensory information via real-time visual biofeedback during gait training can increase MTC.

Methods

Participants will be over 18 years, have sustained a single stroke (ischaemic or hemorrhagic) at least 6 months previously, able to walk 50 metres independently and capable of informed consent. Using a secure web-based application (REDCap) 150 participants will be randomly assigned to either no-feedback (Control) or feedback (Experimental) groups, all will receive 10 sessions of treadmill training for up to 10 minutes at a self-selected speed over five to six weeks. The intervention group will receive real-time, visual biofeedback of MTC during training and will be asked to modify their gait pattern to match a required “target” criterion. Biofeedback is continuous for the first six sessions then progressively reduced (faded) across the remaining four sessions. Control participants will walk on the treadmill without biofeedback. Gait assessments are conducted at baseline, immediately following the final training session and then during follow-up, at 1, 3 and 6 months. The primary outcome measure is MTC. Monthly falls calendars will also be collected for 12 months from enrolment.

Discussion

The project will contribute to understanding how stroke-related changes to sensory and motor processes influence gait biomechanics and associated tripping risk. The research findings will guide our work in gait rehabilitation following stroke and may reduce falls rates. Treadmill training procedures incorporating continuous real-time feedback may need to be modified to accommodate stroke patients who have greater difficulties with treadmill walking.
The effect of a heel-unloading orthosis in short-term treatment of calcaneus fractures on physical function, quality of life and return to work – study protocol for a randomized controlled trial
Authors: Schmal Hagen , Larsen Anders Holsgaard , Froberg Lonnie , Erichsen Julie Ladeby , Madsen Carsten Fladmose , Pedersen Lasse 
Published: March 2019

Abstract
Background
Neither for operative nor non-operative therapy standardized guidelines for rehabilitation of calcaneus fractures are existing. While there is consensus for non- or partial weight bearing, the use of supporting devices such as specific foot ankle orthosis is still a matter of debate. Recently, a heel-unloading orthosis (‘Settner shoe’) was introduced for aftercare of these fractures, allowing walking by shifting the load to the middle- and forefoot. This orthosis enables early mobilization of patients suffering from both one-and two-sided fractures. The ‘Settner shoe’ can be applied in non-operative therapy and following operations. Specifically in calcaneus fractures, early regain of physical activity has been highlighted as one of the key factors for quality of life and the ability to return to work. Thus, we hypothesize that mobilization with the ‘Settner shoe’ results in higher physical activity within the first 3 months, which is the primary outcome criterion.
Methods
This is going to be analyzed by a randomized controlled study comparing treatment with and without this specific orthosis. The secondary outcome measures are the time point of return to work in calcaneus fracture patients aged between 18 and 60 years. Furthermore, the American Orthopaedic Foot and Ankle Society's (AOFAS) ankle-hindfoot score, a 3-dimensional gait analysis, and the EQ-5D-3L questionnaire for quality of life are assessed.
Discussion
It is the first trail applying a standardized rehabilitation protocol in patients suffering from calcaneus fractures aiming to improve the non-operative part of treatment by the use of an orthosis.
Trial registration: NCT03572816