bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hub genes of stroke identified by weighted gene co-expression network analysis
Authors: Li Junhong , Zhai Yang , Wu Peng , Hu Yueqiang , Chen Wei , Zheng Jinghui , Tang Nong 
Published: September 2019

Abstract
Background Microarray-based gene expression profiling has been widely used in biomedical research. Weighted gene co-expression network analysis (WGCNA) can link microarray data directly to clinical traits and to identify rules for predicting pathological stage and prognosis of disease, it has been found useful in many biological processes. Stroke is one of the most common diseases worldwide, yet molecular mechanisms of its pathogenesis are largely unknown. We aimed to construct gene co-expression networks to identify key modules and hub genes associated with the pathogenesis of stroke.Results In this study, we screened out the differentially expressed genes from gene microarray expression profiles, then constructed the free-scale gene co-expression networks to explore the associations between gene sets and clinical features, and to identify key modules and hub genes. Subsequently, functional enrichment and the receiver operating characteristic (ROC) curve analysis were performed. And the results show that a total of 11,747 most variant genes were used for co-expression network construction. Pink and yellow modules were found to be the most significantly related to stroke. Functional enrichment analysis showed that the pink module was mainly involved in regulation of neuron regeneration, and the repair of DNA damage, while the yellow module was mainly enriched in ion transport system dysfunction which were correlated with neuron death. A total of 8 hub genes (PRR11, NEDD9, Notch2, RUNX1-IT1, ANP32A-IT1, ASTN2, SAMHD1 and STIM1) were identified and validated at transcriptional levels (other datasets) and by existing literatures.Conclusions Eight hub genes (PRR11, NEDD9, Notch2, RUNX1-IT1, ANP32A-IT1, ASTN2, SAMHD1 and STIM1) may serve as biomarkers and therapeutic targets for precise diagnosis and treatment of stroke in the future.
What is the best angiographic view for detection of coronary artery abnormality in Tetralogy of Fallot? A retrospective study
Authors: Edraki Mohammad reza , Dehdab Reza , Mehdizadegan Nima , Mohammadi Hamid , Amoozgar Hamid , Ajami Gholam hossein , Borzouee Mohammad , Keshavarz Kambiz , Moradi Poria , Dehghani Elham , Bahrami Reza 
Published: September 2019

Abstract
Background The definite treatment of tetralogy of Fallot (TOF) as the most common cyanotic congenital heart disease is open heart surgery and the operation technique depends on the coronary artery anatomy. We aimed to evaluate the sensitivity and specificity of various root Aortogram views to detect abnormal coronary artery configuration and course in these patients.Methods In this retrospective study, the reports of coronary anatomy in angiography and operation notes of TOF patients since 2005 to 2017 were evaluated. The sensitivity and specificity of the two common root Aortogram views including the left anterior oblique/cranial (LAO/CRA) and left anterior oblique/caudal (LAO/CAU) were determined.Results 451 patients with the median age of 28 months (3-432 months) were included. All patients had LAO/CRA views and 199 patients had both LAO/CRA and LAO/CAU views. The rate of coronary abnormalities reported by surgery was 8%, and abnormal origin of the left anterior descending artery from the right coronary artery was the most common reported anomaly (4.4%). The sensitivity of the LAO/CAU view was 100%, but LAO/CRA view was about 75% in detecting abnormal coronary configuration. Both of them had excellent specificity (~100%). No significant sex difference was seen between different coronary anatomy abnormalities.Conclusion The Caudal root angiogram is an essential view to evaluate coronary artery anatomy in TOF patients and it seems that there is no need for other views like lateral view, but relying on LAO/CRA view alone may lead to significant misdiagnosis of the coronary arteries, crossing the right ventricular outflow tract (RVOT).
A systematic review of health economic evaluation of targeted therapies for first-line treatment of metastatic non-small cell lung cancer (NSCLC): Quality evaluation
Authors: Zhao Jie , Du Shuzhang , Liang Yan , Li Hongchao , Chang Feng , Lu Jingli , Ma Xiaohua , Zhang Xiaojian 
Published: September 2019

Abstract
Backgroud: Evolving practice in non-small cell lung cancer (NSCLC) therapy inevitably impacts health care budgets, especially the introduction of targeted therapies. This results in a rise of health economic evaluations (HEEs) in this domain. The objective of this article is to review the quality of the economic evidence of targeted therapies in metastatic NSCLC. Methods: A literature search using Pubmed, Cochrane, Embase and CRD (University of York Centre for Reviews and Dissemination) database was conducted to identify original articles published between 1/1/2000 and 31/3/2019. A quality of reporting assessment using CHEERS (Consolidated Health Economic Evaluation Reporting Standards statement) was translated into a quantitative score and compared with QHES (Quality of Health Economic Studies) evaluation. Results: Twenty-one HEEs were analyzed. In CHEERS assessment, method description integrity (including setting, perspective, time horizon and discount rate), justification of data sources and heterogeneity description were often absent or incomplete. Only four studies reach the standard of good quality. Modeled articles were mainly evaluated by the QHES instrument, lack of illustrated structure, formula of the transitioning probability and justification for the choice of the model were the most frequent problems in selected studies. After quantification, the CHEERS-scores did not differ significantly from QHES-scores. Conclusion: The overall quality of HEEs in NSCLC targeted therapies is not high. In addition, further efforts are needed to improve the standardization of the model application and the transparency of data description, which is indispensable for valid decision-making on scarce health care resource allocation.
Unfavorable impact of scheduled cesarean section at 36 gestational weeks for placenta previa
Authors: Ohshita Mio , Miyamoto Morikazu , Ishibashi Hiroki , Soyama Hiroaki , Nakatsuka Masaya , Iwahashi Hideki , Kakimoto Soichiro , Matsuura Hiroko , Sakamoto Takahiro , Kawauchi Haruka , Hada Taira , Takasaki Kazuki , Takano Masashi 
Published: September 2019

Abstract
Background Pregnant women with no risk factors should have received elective CS later than 37 weeks because the the incidence of respiratory disorder of neonates decreases [5-8]. Hence, the appropriate timing that CS for placenta previa was performed on the side of both the mother and neonate was unclear. This study aimed to evaluate the most appropriate timing of cesarean section (CS) in placenta previa cases. Methods Singleton pregnant women who were scheduled to undergo an elective CS at 36 weeks (Group A) or 37 weeks of gestation (Group B) for placenta previa between August 2003 and July 2018 at our hospital were identified. The timing of CS was decided based on the judgment of the doctor with consideration of the risk of bleeding or faculties adaptation. Maternal and neonatal outcomes between both groups were retrospectively examined. Results There were a total of 272 cases, with 76 cases assigned in Group A and 196 cases in Group B. There was no difference in emergency CS rate (p = 0.36), intraoperative hemorrhage (p= 0.86), total hemorrhage at delivery (p= 0.64), and additional treatment between Group A and Group B. The birth weight of neonates in Group A was smaller (p < 0.001) compared to those in Group B. Apgar scores of neonates at 1 minute (p = 0.04) and 5 minutes (p < 0.01) were lower in Group A than in Group B. Furthermore, neonatal hypoglycemia was higher in neonates of Group A (p < 0.02). Conclusions Regardless of selection bias, there were no merits to perform CS for placenta previa at 36 gestational weeks on both mother and neonate sides. Further studies are required to evaluate when elective CS for placental previa should be scheduled.
Husbands’ participation in birth preparedness and complication readiness and associated factors in Kucha district, GamoGofa Zone, Southern Ethiopia
Authors: Tantu Zinash , Gultie Teklemariam , Estifanos Wubshet , Sidemao Negussie Boti 
Published: September 2019

Abstract
Background Birth-preparedness and complication-readiness (BPCR) is the process of planning for normal birth and anticipating the actions needed in case of an emergency. The involvement of husband during pregnancy and its complication helps an expectant mother to make timely decisions to avoid delays. Therefore, this study aims to assess the level of husband involvement in birth preparedness and complication readiness and associated factors in Kucha District, Gamo Zone, Southern Ethiopia.Methods Community-based cross-sectional study was conducted 421 among husbands with a wife who gave birth within the last 12 months at Kucha District. A simple random sampling technique was used to select the study subjects. Data were collected using a pretested interviewer-administered questionnaire by trained data collectors. Binary and multivariable logistic regression with odds ratios along with the 95% confidence interval analysis were employed to find factors associated with the dependent variable. A p-value <0.05 with 95% confidence level were used to declare statistical significance.Result Data collected from 421 husbands. One hundred twenty-seven (30.2%) husband involved in birth preparedness and complication readiness plan. Husbands who attend secondary and higher level of school (AOR=3.1, CI (1.84-5.23)), husbands whose wives had antenatal care follow up four and above (AOR=4.91, CI (2.36-10.2)), and husbands whose reside more than 5 km from health care facility (AOR=2.35, CI=1.40-3.96)), were significantly associated with husband involvement in birth preparedness and complication readiness.Conclusion Husbands involvement during birth preparedness and complication readiness was 30.2%. Educational level, the frequency of antenatal care, and the distance to the health facility were factors significantly affect the husbands’ involvement.
Fault diagnosis method for energy storage mechanism of high voltage circuit breaker based on CNN characteristic matrix constructed by sound-vibration signal
Authors: Zhao Shutao , Wang Erxu , Hao Jiawei 
Published: September 2019

Aiming at the problem that some traditional high voltage circuit breaker fault diagnosis methods were over-dependent on subjective experience, the accuracy was not very high and the generalization ability was poor, a fault diagnosis method for energy storage mechanism of high voltage circuit breaker, which based on Convolutional Neural Network (CNN) characteristic matrix constructed by sound-vibration signal ,was proposed. In this paper, firstly, the morphological filtering was used for background noise cancellation of sound signal, and the time scale alignment method based on kurtosis and envelope similarity were proposed to ensure the synchronism of the sound-vibration signal. Secondly, the Pearson correlation coefficient was used to construct two-dimensional image characteristic matrix for the expanded sound-vibration signal. Finally, the characteristic matrix was trained by utilizing CNN. Local Response Normalization (LRN) and core function decorrelation were utilized to improve the structure of CNN model, which reduced the bad impact of large data fluctuation of energy storage process on the diagnostic accuracy of circuit breaker energy storage mechanism. Compared with the traditional method, the proposed method has obvious advantages, whose total accurate rate up to 98.2 % and generalization performance is excellent.
Modelling PAHs removal in activated sludge process: effect of disintegration
Authors: Mozo I. , Bounouba M. , Mengelle E. , Lesage N. , Sperandio M. , Bessiere Y. 
Published: September 2019

Abstract
The removal of polycyclic aromatic hydrocarbons (PAHs) in activated sludge was evaluated using two laboratory-scale bioreactors, coupled or not with a disintegration system (sonication). Mass balances performed on each system underlined that PAHs removal was significantly improved after sludge disintegration, especially for the higher molecular weight PAHs studied, which tended to adsorb to suspended matter. A model was developed in order to study the effect of sludge disintegration on the content of dissolved and colloidal matter (DCM), and to predict the potential impacts on PAHs availability and degradation. Results showed that this new model was efficient for capturing apparent degradation improvement trends and for discriminating between the involved mechanisms. This study showed that DCM content increased after sludge disintegration, and proved to be the main driver for improving PAHs apparent degradation.
Competences of physical education teachers in the sports injuries prevention
Authors: Uspuriene Aiste Barbora , Iurgelaitis Vilius 
Published: September 2019

School is a place where children spend most of their time. Thus, it is particularly important to ensure that it has a healthy and safe learning environment. Quite often, children experience injuries during physical education classes. Considering to the problem of children injuries in physical education classes, it is important to examine their prevalence, to analyze the causes of injury in physical education classes to prevent or reduce them. There is still a lack of research on the competence of physical education teachers in the prevention of sports injuries. Research aim – to identify the competences of physical education teachers for the sports injuries prevention. Using the questionnaire survey we investigated that physical education teachers pay attention to the warm-up and correct exercise in the physical education lesson. Students are rarely injured in the lessons of these physical education teachers. The research showed that competencies of surveyed physical education teachers are high.
Sex Differences in the Relationship between PTSD Spectrum Symptoms and Autistic Traits in a Sample of University Students
Authors: Carpita B. , Muti D. , Muscarella A. , Dell’Oste V. , Diadema E. , Massimetti G. , Signorelli M.S. , Fusar Poli L. , Gesi C. , Aguglia E. , Politi P. , Carmassi C , Dell’Osso L. 
Published: September 2019

Background:While growing literature is stressing the link between Autistic Traits (AT) and trauma-/stress-related disorders, in both conditions significant differences have been separately reported.Objective:This study aims to evaluate the relationship between AT and trauma-/stress-related symptoms with respect to sex.Methods:178 university students were assessed with the Structured Clinical Interview for DSM-5, the Trauma and Loss Spectrum (TALS) and the Adult Autism Subthreshold Spectrum (AdAS). In order to evaluate sex differences in trauma-/stress-related symptoms among subjects with higher or lower AT,the sample was split in two groups with an equal number of subjects on the basis of the median score reported on AdAS Spectrum (“AdAS high scorers” and “AdAS low scorers”).Results:Females reported significantly higher TALS total score,Loss eventsandGrief reactiondomain scores than males in the whole sample, while AdAS high scorers reported significantly higher TALS total and domain scores than AdAS low scorers. A significant interaction between high/low AdAS score and sex emerged for TALS domains, with females scoring significantly higher than males only among AdAS low scorers, specifically onLoss events,Grief reaction,Re-experiencingandPersonal characteristics/Risk factorsdomains. Finally, among AdAS high scorers a significantly higher rate of subjects fulfilled symptomatological criteria for PTSD than among AdAS low scorers, without sex differences.Conclusion:Our results confirm a significant relationship between AT and trauma-/stress-related symptoms, which seems to prevail on sex differences among high-risk subjects.
Методика измерения параметров вогнутых крупногабаритных асферических зеркал с помощью датчика волнового фронта
Authors: Пискунов Т.С. , Барышников Н.В. , Животовский И.В. , Сахаров А.А. ,  Соколовский В.А. 
Published: September 2019

AbstractA methodology has been developed for measuring radius R _v and eccentricity (conic parameter k ) of large concave aspherical mirrors using a wavefront sensor. Analytical expressions that directly relate Zernike coefficients a _4 and a _9 to parameters R _v and k of the mirror are obtained. It is shown that the technique does not require accurate mirror alignment before measurements. A computer analysis showed that the developed scheme enables measurements with errors of δ R _v < 0.1% and δ k < 0.01 for mirrors with radii from 100 to 2000 mm and with errors of δ R _v < 0.01% and δ k < 0.001 for mirrors with radii of more than 5000 mm.
Фоторазрушение субмикронных кристаллов DAST в пленке PMMA путем прямой лазерной записи
Authors: Погосян Т.Н. , Денисюк И. Ю. , Лай Н.Д. , Леду-Рак И. 
Published: September 2019

AbstractSelective photobleaching of DAST ( trans -4'-(dimethylamino)-Nmethyl-4-stilbazolium tosylate) non-linear crystals in a 2-μm-thick polymethacrylate film using direct laser writing at a wavelength of 532 nm at a power of 1–10 mW and a recording speed of 5–35 μm/s is studied. The laser pattern is established as a function of recording parameters. The destruction of crystals and their transition into the amorphous state enabled one to record a structure that is well resolved in the optical microscope and in the luminescence signal. No layer surface violation at the crystal damage sites is detected. The method ensures the formation of a grating with a periodic modulation of the nonlinearly optical coefficient, which is essential in the quasi-phasematching generation.
Calidad de la leche cruda para consumo humano en dos localidades de Sucre (Colombia)
Authors: Arrieta B Germán , Gomezcaceres P Luty , Albis F Dalila , Calderón-Rangel Alfonso , Rodríguez R Virginia 
Published: September 2019

Objetivo. Determinar la calidad fisicoquímica, microbiológica y recuento de células somáticas de leches crudas que se distribuyen para consumo humano en diferentes barrios de Sincelejo y Corozal (Sucre). Materiales y métodos. Mediante un estudio descriptivo de corte transversal, se tomaron 97 muestras de leche cruda; se determinaron algunos parámetros fisicoquímicos, microbiológicos y recuento de células somáticas. Los datos obtenidos se analizaron de acuerdo a la normatividad vigente en Colombia. Resultados. La mayoría de los parámetros fisicoquímicos de las muestras de leche cruda evaluadas se encontraron dentro de los parámetros normales de la legislación colombina. El recuento estándar en placa y el recuento de células somáticas se encontraron por encima de lo permitido por la legislación. Se demostró la presencia de coliformes totales, coliformes fecales, antibióticos y adulterantes como sacarosa y almidones. Conclusiones. La leche cruda que se distribuye para consumo humano en Sincelejo y Corozal presenta buena calidad fisicoquímica pero deficiente calidad microbiológica; se hace necesario incrementar la vigilancia y exigir al eslabón primario de la cadena láctea la producción de leche de excelente calidad.
Risk Factors for 1-Year Graft Loss After Kidney Transplantation
Authors: Foroutan Farid , Friesen Erik Loewen , Clark Kathryn Elizabeth , Motaghi Shahrzad , Zyla Roman , Lee Yung , Kamran Rakhshan , Ali Emir , De Snoo Mitch , Orchanian-Cheff Ani , Ribic Christine , Treleaven Darin J. , Guyatt Gordon , Meade Maureen O. 
Published: September 2019

Background and objectives
With expansion of the pool of kidney grafts, through the use of higher-risk donors, and increased attention to donor management strategies, the 1-year graft survival rate is subject to change. It is, therefore, useful to elucidate 1-year graft survival rates by dissecting the characteristics of the low-risk and high-risk kidney transplant cases. The objective of our study was to evaluate factors purported to influence the risk of 1-year graft loss in kidney transplant recipients.

Design, setting, participants, & measurements
We searched bibliographic databases from 2000 to 2017 and included observational studies that measured the association between donor, recipient, the transplant operation, or early postoperative complications, and 1-year death-censored graft loss.

Results
We identified 35 eligible primary studies, with 20 risk factors amenable to meta-analysis. Six factors were associated with graft loss, with moderate to high degree of certainty: donor age (hazard ratio [HR], 1.11 per 10-year increase; 95% confidence interval [95% CI], 1.04 to 1.18), extended criteria donors (HR, 1.35; 95% CI, 1.28 to 1.42), deceased donors (HR, 1.54; 95% CI, 1.32 to 1.82), number of HLA mismatches (HR, 1.08 per one mismatch increase; 95% CI, 1.07 to 1.09), recipient age (HR, 1.17 per 10-year increase; 95% CI, 1.09 to 1.25), and delayed graft function (HR, 1.89; 95% CI, 1.46 to 2.47) as risk factors for 1-year graft loss. Pooled analyses also excluded, with a high degree of certainty, any associations of cold ischemia time, recipient race, pretransplant body mass index, diabetes, and hypertension with 1-year graft loss.

Conclusions
Recipient age, donor age, standard versus extended criteria donor, living versus deceased donor, HLA mismatch, and delayed graft function all predicted 1-year graft survival. The effect of each risk factor is small.
The Association between Internal Audit Operations-Related Services and Firm Operating Performance
Authors: Jiang Like , Messier William F. , Wood David A. 
Published: September 2019

SUMMARY
We examine whether operations-related services (ORS) provided by the internal audit function (IAF) bring economic benefits to firms. Using a sample constructed by matching a global internal auditor survey with public firms' data in Compustat, we find that the IAF's involvement in ORS has a significant positive association with operating performance. By decomposing ORS into traditional assessment services (e.g., operational audit) and business-oriented facilitation services (e.g., strategy consulting), we document that assessment services are prevalent whereas facilitation services are less frequent. Both types of services have a positive association with operating performance. Moreover, we find that the positive relation between ORS and operating performance is only achieved for companies that follow a defender (as opposed to a prospector) business strategy and that extensively outsourcing internal audit activities reduces the positive effect of ORS on operating performance. Overall, our findings shed light on the value added by the IAF.
JEL Classifications: M41; M42.
Preservation of Incentives Inside the Firm: A Case Study of a Quasi-Market for Cost-Based Transfer Pricing
Authors: Friis Ivar 
Published: September 2019

ABSTRACT
According to organizational economists, the implementation of market-like control mechanisms, such as transfer prices, can never completely replicate the market since “the use of high-powered incentives in firms is inherently subject to corruption” (Williamson 1985, 140). This paper illustrates that this is not necessarily always so. By means of a case study, this paper illustrates that many problems that extant research claims are related to cost-based transfer prices were mitigated through an organizational design that created a quasi-market inside the firm. The paper contributes to extant research in several ways. First, it illustrates that strong incentives are somewhat preserved through an organizational design that fosters competition between product divisions. Second, the paper shows how the specific problems related to a standard variable cost transfer price were mitigated. Finally, the paper highlights the limits of the quasi-market and describes a number of problems that required central intervention.