bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paroxetine Hydrochloride Push-pull Osmotic Pump Tablets: Designing an Innovative, Scalable Push-pull Osmotic Drug Delivery System Using QbD Approach
Authors: Kenjale Prathmesh P. , Joshi Manjusha A. , Khatavkar Umesh N. , Dhapte Vividha V. , Pokharkar Varsha B. 
Published: September 2019

Background:
Paroxetine hydrochloride hemihydrate (PHH) is a serotonin reuptake inhibitor
useful for the treatment of diverse psychiatric problems. Existing marketed formulations with frequent
administration lead to gastrointestinal (GI) reactions and abrupt fluctuations in plasma level with poor
patient compliance. These prerequisites are sufficed by controlled release push-pull osmotic pump tablets
(PPOP).

Objective:
Objective of the present study was to develop robust and reliable PPOP formulation via
Quality by design (QbD) approach to achieve desired release kinetics.

Methods:
PPOP was formulated using wet granulation method followed by osmotic coating. QbD
strategy for defining the risk assessment of influential variables such as swelling polymers and
osmogen on in vitro release kinetics of designed PPOP.

Results:
Presence of Polyox in push and pull layer along with osmogen controlled the drug release
pattern from formulated PPOP system as depicted in 33 factorial design. These formulated optimized
PPOP systems demonstrated 2 hrs lag time with zero-order kinetics, a peculiar feature of PPOPs.

Conclusions:
Scalable, stable PPOP tablets were fabricated by applying systematic QbD approach. The
developed PPOP systems with improved concentration-independent behavior helped to address the
challenges of existing marketed formulations. Risk mitigation and control strategy assured quality of
the system during scalability. Application of QbD strategy in establishing the PPOP formulation would
help in formulating drug candidates having gastric limitations and poor patient compliance. The present
study is the detailed account of QbD based PPOP formulation, therefore it can be of potential importance
from academics as well as industrial perspective.
Evaluation of Anticancer Activities of Gallic Acid and Tartaric Acid Vectorized on Iron Oxide Nanoparticles
Authors: Saleh Lina , Ragab Eman A. , Abdelhakim Heba K. , Mohamed Sabrein H. , Zakaria Zainab 
Published: September 2019

Background:
Cancer is one of the leading causes of death. New tactics targeting the survival
pathways that provide effective drugs are being developed.

Objective:
Super paramagnetic nanoparticle serves as drug carrier for drug delivery system. Herein,
Iron oxide-CMC-TA and Iron oxide-CMC-GA nanoparticles are synthesized for this target.

Methods:
Iron oxide (Fe2O3) nanoparticles are synthesized, bound to carboxymethyl chitosan (CMC)
which are then conjugated to tartaric acid (TA) or gallic acid (GA) to form Iron oxide-CMC-TA and
Iron oxide-CMC-GA nanoparticles. Those nanoparticles were characterized and the cytotoxicity effect
was evaluated when associated with/without bee venom to measure the synergistic effect on A549 and
WI-38 cell lines. In addition, apoptotic genes expression in A549 was evaluated when treated with both
nanoparticles.

Results:
We showed that the cytotoxicity effect of TA and GA on A549 and WI-38 cell lines was increased
when they immobilized on iron oxide-CMC nanoparticles and the effect was synergistically
elevated when added to bee venom. The cytotoxic activity of these two nanoparticles was higher in
A549 cancer cell line when compared with WI-38 normal cell line. Moreover, the expression of apoptotic
genes was elevated.

Conclusion:
Iron oxide-CMC-TA nanoparticle and Iron oxide-CMC-GA nanoparticle can selectively
induce apoptosis in cancer cell lines more than in normal cell lines, which is an important aspect in cancer
cell targeting process to minimize damage upon normal cells.
Psychometric Properties of the French Version of the Borderline Personality Features Scale for Children and Adolescents
Authors: Ensink Karin , Bégin Michaël , Kotiuga Judith , Sharp Carla , Normandin Lina 
Published: September 2019

Background:
The Borderline Personality Feature Scale for Children (BPFS-C) is
currently the only dimensional measure of child and adolescent borderline features and the
English version has been shown to have good psychometric properties. To extend the use of
this measure with French speaking adolescents, it is essential to examine the reliability and
validity of the French BPFS-C.

Objective:
The present study sought to assess the psychometric properties of the French
BPFS-C.

Methods:
A community sample of 394 adolescents and young adults completed the Borderline
Personality Features Scale for Children (BPFS-C), as well as the Million Adolescent
Clinical Inventory (MACI) borderline tendency subscale, the Child Behavior Checklist-
Youth Self-Report (CBCL-YSR) and the Beck Youth Inventories (BYI).

Results:
The findings show that both the long and short French BPFS-C have good internal
consistency and convergent validity. Affect regulation, identity, relationship difficulties and
self-harm were found to be closely inter-connected rather than distinct factors.

Conclusion:
The findings indicate that both long and short versions of French BPFS-C have
good psychometric properties and provide preliminary evidence that the total scores are reliable
and valid indicators of borderline personality features in adolescents and young adults.
Specific Enzymatic Activity of Ceruloplasmin as a Potential Indicator of Copper Status
Authors: Upadhyay Kuldip , Viramgami Ankit 
Published: September 2019

Background::The serum copper (Cu) and ceruloplasmin (Cp) concentrations are common blood markers of copper metabolism. In altered physiological conditions, Cp can act as an acute phase reactant and its concentration may increase.Objective::To evaluate specific enzymatic activity of Cp as a potential indicator of Cu status and its correlation with serum Cu level.Methods::Serum Cu levels were estimated as per NIOSH method. Specific enzymatic activity of Cp was determined from enzymatic activity and immune concentration of Cp as per standard methods. The statistical analysis was carried out using the package of social science (SPSS) software.Results::The difference in mean specific enzymatic activity of Cp was statistically significant between clinical and control groups. In control population, the correlation between serum Cu level and specific enzymatic activity of Cp was moderate and statistically significant (r=0.566, p=0.014, N=18) as compared to the clinical group (r=0.338, p=0.016, N=50).Conclusion::The study revealed that clinical group was significantly different in specific enzymatic activity of Cp as compared to control group. Besides this, the specific enzymatic activity of Cp was moderately but significantly correlated with serum Cu level in control group but did not reveal conclusive evidence in clinical population.
Technique for Optimization of Association Rule Mining by Utilizing Genetic Algorithm
Authors: Patel Darshana H. , Shah Saurabh , Vasant Avani 
Published: September 2019

Background:
Due to advancement in usage of Internet and pattern discovery from huge
amount of data flowing through internet, personal information of an individual or organization can be
traced. Hence, to protect the private information is becoming extremely crucial, which can be achieved
through privacy preserving data mining.

Objective:
The main objective to preserve the privacy of data and to maintain the balance between privacy
and accuracy by applying privacy preserving technique and optimization respectively.

Methodology:
The generation of class association rule is done by utilizing associative classification
technique namely class based association due to its simplicity which serves the purpose of classifying
the data. Furthermore, privacy of the data should be maintained and hence privacy preserved class association
rules are produced by applying privacy preserved technique namely anonymization. Hence, optimization
technique specifically genetic algorithm as well as neural network has been applied to maximize
the accuracy.

Results:
(Four various real datasets has been utilized for different experimentation).

:
Implemented Classification Based on Association (CBA) algorithm of Associative Classification technique
and it provides virtuous accuracy as compared to other techniques by setting the support as 0.2
and confidence at 0.6.

:
Privacy preserving techniques namely k-anonymization was implemented to preserve the privacy but it
has been observed that as privacy (k-level) increases, accuracy (percentage) decreases due to data transformation.

Conclusion:
(Hence, optimization technique namely Genetic Algorithm (GA) and Neural Network
(NN) has been implemented to increase the accuracy (probably 7-8%). Furthermore, on comparison of
GA and NN considering the time parameter, GA outperforms well.
An Evidence-based Study on Pharmacological Treatments of Non-Alcoholic Fatty Liver Disease Based on Traditional Persian Medicine
Authors: Hasheminasab Fatemeh Sadat , Tajadini Haleh , Setayesh Mohammad 
Published: September 2019

Background:
Non-Alcoholic Fatty Liver Disease (NAFLD) is one of the most
prevalent liver diseases regarded as the primary cause of chronic liver disease, which may
lead to hepatic failure. Despite the recent developments in the treatment of NAFLD, the necessity
to find more efficient treatments has led to investigation on medicinal plants. Traditional
Persian Medicine (TPM) is one of the oldest medical schools in the world. For treatment
of NAFLD, different medicinal plants have been employed in TPM.

Objective:
Considering the public welcome for herbal medicines, the current evidence-based
review study is conducted to investigate herbal remedies for NAFLD in TPM.

Methods:
Medicinal plants for treating NFALD were extracted according to three famous
textbooks of Persian medicine. Then anti-obesity, hypolipidemic, hypoglycemic, antioxidative
and hepatoprotective effects of these medicinal plants were investigated according
to modern medicine. For this purpose, databases including Scopus, web of sciences, Pubmed,
Google scholar and science direct were searched.

Results:
Investigations of Persian medicine textbooks resulted in deriving 53 herbs, which
are useful for treating NAFLD. Searching through aforesaid databases showed that most of
these plants can help to treat this disease in at least 2 ways. 25 herbs are effective in all 5
mentioned effects.

Conclusion:
It should be considered that in Persian medicine, first-line treatment is correction
of life style, then if necessary, herbs are prescribed. However, this study showed that
many herbs mentioned in Persian medicine for treatment of NAFLD might have a potential
to aid patient with this disease.
Penerapan Teknik Shaping untuk meningkatkan durasi on-task behavior pada anak dengan masalah atensi
Authors: Anjani Savira , Tjakrawiralaksana Mita Aswanti 
Published: September 2019

Abstrak. Kemampuan mempertahankan atensi terlihat pada on-task behavior, dimana anak mampu mengerjakan tugas tanpa melakukan kegiatan lain yang tidak berkaitan. On-task behavior menjadi target perilaku yang ingin diintervensi pada S, anak laki-laki berusia 4 tahun 5 bulan dengan diagnosa Attentional Disorder (ICDL-DMIC). Berdasarkan pemeriksaan, rentang atensinya berada dibawah taraf rata-rata anak seusianya dan terlihat dari kesulitannya dalam menyelesaikan kegiatan. Penelitian single-subject ini bertujuan untuk melihat efektivitas dari penerapan teknik shaping dalam meningkatkan durasi on-task behavior pada anak dengan masalah atensi, dengan hipotesa teknik shaping mampu meningkatkan durasi on-task behavior. Terdapat peningkatan durasi saat intervensi diberikan. Dalam intervensi ini, orangtua memiliki peran besar sebagai pemberi prompt dan reinforcement untuk mempermudah proses generalisasi.Kata Kunci: Shaping, On-Task Behavior, Attentional DisorderAbstract. The ability to maintain attention is seen from on-task behavior, when child can do a task without do other unrelated activities. On-task behavior is the targeted behavior to intervene from S, a 4 years 5 months old boy with a diagnosis Attentional Disorder (ICDL-DMIC). Based on asssessment, S has shorter duration of attention than the expected duration of his age and shown on his difficulties in finishing any activities. This single-subject research aims to examine the effectiveness of the application of shaping technique in increasing the duration of on-task behavior, and hypothesized that it’s application will increase on-task behavior’s duration. The result shows that there is an increase in on-task behavior’s duration. In this research, parents took a bigger role as prompt and reinforcer giver to ease the process of generalization. Keywords: Shaping, On-Task Behavior, Attentional Disorder
REFLEKSI KONSEP KETUHANAN AGAMA KRISTEN DAN AGAMA ISLAM DALAM PANDANGAN FILSAFAT PERENIAL
Authors: Pardosi Milton Thorman , Murtiningsih Siti 
Published: September 2019

Agama Kristen dan Agama Islam adalah dua agama yang diturunkan oleh Allah, keturunan Abraham dan memiliki Kitab Suci yang diwahyukan Allah. Keduanya sama-sama mempercayai Allah Yang Maha Esa, Sang Pencipta. Tujuan penulisan ini untuk memahami konsep ketuhanan agama Kristen dan Islam dan memahami refleksi ketuhanan kedua agama tersebut dalam Filsafat Perenial. Dalam pemahaman agama Kristen, Allah itu Esa yang merujuk kepada kualitatif. Sementara kata Allah bukanlah nama Oknum yang disembah melainkan gelar karena kata “Allah” juga digunakan baik kepada sesembahan Bangsa Israel dan Non-Israel. Salah satu nama Allah dalam Alkitab adalah Yahweh. Sementara dalam pemahaman agama Islam, konsep Allah adalah Esa merupakan salah satu rukun iman (Tauhid) dan ini merujuk kepada kuantitatif. Konsep Esa ini adalah monoteisme murni, di mana Tuhan bukan hanya jumlahnya Esa melainkan sifatnya pun Esa. Perbedaan pemahaman ketuhanan kedua agama tersebut dapat dilihat melalui Filsafat Perenial di mana Filsafat Perenial merupakan metafisika yang mengakui realitas Ilahi yang substansial bagi dunia benda, hidup dan pikiran. Filsafat Perenial memberikan analog tentang Tuhan seperti cahaya matahari yang satu dan ketika ditangkap oleh prisma memunculkan beraneka macam warna. Itu sebabnya Filsafat Perenial melakukan dua pendekatan yaitu: Eksoteris yang berfungsi sebagai dasar pijakan pemahaman tentang Tuhan berdasarkan perkataan Tuhan tentang dirinya melalui wahyu; Pendekatan Esoterik adalah pemahaman langsung tentang Tuhan melalui penyatuan seluruh potensi kemanusiaan yang dikenal sebagai “jalan” mistik. Kesimpulannya, agama Kristen dan agama Islam adalah menyembah Allah yang sama yaitu Allah Yang Maha Esa, Sang Pencipta (Esoterik). Kedua, kata Esa, dalam pemahaman agama Kristen berarti kualitatif sementara dalam Agama Islam berarti kuantitaf (Eksoterik). Ketiga, kata Allah dipahami berbeda, yang satu sebagai gelar, namun bagi yang satu sebagai nama (Eksoterik). Kata Kunci: Perenial, Allah, Esa
HUBUNGAN MOTIVASI BELAJAR TERHADAP KINERJA SISWA DALAM PRAKTIKUM INSTALASI TENAGA LISTRIK DI KELAS XI TIPTL SMK N 3 SINGARAJA
Authors: Setiawan Praja , Arsa Putu Suka , Indrawan Gede 
Published: September 2019

This study is aimed to determine (1) the relationship between learning motivation to the students' performance in the electric power installation practicum in the students of class XI TIPTL in SMK Negeri 3 Singaraja, (2) to know the level of students’ motivation on the subjects of electric power installation expertise program of Installation Technique of Power Utilization Electricity class XI in SMK Negeri 3 Singaraja, and (3) to know the level of students’ performance in electrical power installation practice in grade XI students of Electrical Power Installation Engineering program at SMK Negeri 3 Singaraja. (4) to know the relation of students’ performance in electric power installation practicum with students’ motivation of class XI TIPTL. This research is a correlational research. Samples studied were students of class XI TIPTL with number of samples are as many as 62 students. There are two variables studied which are dependent variable, that is students’ performance and one independent variable, that is learning motivation. Performance value data was obtained through observation sheet, while for value motivation was obtained through questionnaire distribution, to get explanation about the relationship given between research variables was done by using spearman rank test technique by first performing assumption test, ie normality test, linearity test, and heterocedasticity test. The result of this research is motivation level with average grade 96,06% while for students’ performance in doing electric power installation at student of class XI in SMK Negeri 3 Singaraja obtained average class equal to 69,95% in very good category. So in this study the relationship between motivation and student performance in praktikum electrical installation on students of class XI TIPTL in SMK Negeri 3 Singaraja with correlation coefficient obtained by 0.647 with a significance value of 0.05 which means the direction of positive correlation with a strong correlation level, For the theacher SMK Negeri 3 Singaraja to more motivation students to better support the learning process of students as an effort to improve student performance.
PENGARUH PROBLEM BASED LEARNING BERBANTUAN MEDIA AUDIO VISUAL TERHADAP KEMAMPUAN BERPIKIR KRITIS DAN HASIL BELAJAR IPA DI SEKOLAH DASAR
Authors: Purbarani Dyah Aini , Dantes Nyoman , Adnyana Putu Budi 
Published: September 2019

Penelitian ini memiliki tujuan utama untuk mengetahui pengaruh problem based learning berbantuan media audio visual terhadap kemampuan berpikir kritis dan hasil belajar IPA siswa. Populasi penelitian ini adalah seluruh siswa kelas III gugus X Buleleng yang berjumlah 102 siswa dan sampel berjumlah 58 siswa. Penetapan sampel dilakukan dengan teknik random sampling. Penelitian ini merupakan quasi eksperimen dengan rancangan Nonequivalent Posttest Only Control Group Design. Teknik pengumpulan data kemampuan berpikir kritis menggunakan tes essay sedang data hasil belajar IPA menggunakan tes pilihan ganda. Data dianalisis menggunakan uji manova. Berdasarkan penelitian yang telah dilakukan dapat disimpulkan bahwa: 1) terdapat pengaruh pendekatan saintifik berbasis problem based learning berbantuan media audio visual terhadap kemampuan berpikir kritis pada siswa kelas III di sekolah dasar; 2) terdapat pengaruh pendekatan saintifik berbasis problem based learning berbantuan media audio visual terhadap hasil belajar IPA pada siswa kelas III di sekolah dasar; dan 3) terdapat pengaruh pendekatan saintifik berbasis problem based learning berbantuan media audio visual terhadap kemampuan berpikir kritis dan hasil belajar IPA secara simultan pada siswa kelas III di sekolah dasar.
PENGEMBANGAN INSTRUMEN ASESMEN KETERAMPILAN BELAJAR DAN BERINOVASI PADA MATA PELAJARAN IPA SD
Authors: Ayu PE Sastrika , Marhaeni AAIN , Budiadnyana Putu 
Published: September 2019

AbstrakPenelitian ini bertujuan untuk (1) mengetahui kebutuhan terhadap instrumen asesmen keterampilan belajar dan berinovasi pada mata pelajaran IPA SD. (2) mengetahui design instrumen asesmen keterampilan belajar dan berinovasi pada mata pelajaran IPA SD. (3) mengetahui kualitas instrumen asesmen keterampilan belajar dan berinovasi pada mata pelajaran IPA SD hasil pengembangan dari aspek validitas, reliabilitas dan kepraktisan. Jenis penelitian yang digunakan dalam penelitian ini merupakan penelitian pengembangan yang diadaptasi dari model 4-D yang dikembangkan oleh Thiagarajan (1974). Pengembangannya terdiri dari empat tahap yaitu define, design, develop dan disseminate. Penelitian ini dilaksanakan di seluruh sekolah dasar gugus 6 Kecamatan Banjar Buleleng Bali. Hasil penelitian menunjukkan bahwa: (1) instrumen keterampilan belajar dan berinovasi sangat dibutuhkan oleh siswa SD. Hal ini dikarenakan kegiatan asesmen sangat penting dalam pembelajaran untuk mengetahui sejauh mana keterampilan belajar dan berinovasi peserta didik, (2) design instrumen asesmen keterampilan belajar dan berinovasi pada mata pelajaran IPA SD mengacu pada kriteria secara kualitatif maupun secara kuantitatif. Ketrampilan berpikir kritis, pemecahan msalah dan kreativitas siswa berupa tes uraian, sedangkan keterampilan berkomunikasi dan keterampilan berkolaborasi berupa lembar observasi, (3) kualitas Instrumen asesmen keterampilan belajar dan berinovasi pada mata pelajaran IPA SD hasil pengembangan sudah memenuhi dari aspek validitas, reliabilitas dan kepraktisan.Kata-kata kunci: pengembangan instrumen asesmen, keterampilan belajar dan berinovasi
Review of court decisions based on the jury’s decision in the supervisory instance
Authors: Koryakovtsev V. 
Published: September 2019

The subject. The article discusses the procedural peculiarities and grounds for the supervisory (cassation) review of court decisions based on the jury’s decision.The purpose of the article is to assess the effectiveness of the rules on the grounds for review of courts’ decisions based on jury’s verdict.The description of methodology. The author uses formal-legal and comparative-legal methods as well as legal interpretation of the text of Russian Criminal Procedure Code and Russian Supreme Court’s decisions. The decisions of Russian Constitutional Court and court statistics are also analyzed.The main results and scope of their application. In the introduction the author substantiates the relevance of the proposed research by creating a separate cassation and appeal courts of General jurisdiction, a significant extension of jurisdiction of the Russian court with participation of jurors in the district courts as of 1 June 2018., that will result in a manifold increase in the cases before the courts with participation of jurors in the first instance, and a manifold increase in appeals and representations on the decision of the jury. In the second section of the work the characteristic of legal institution of possible turn to the worst for the condemned situation in cassation and Supervisory instances is given, the analysis is widely known of the resolution of the constitutional court of the Russian Federation of May 11, 2005. The third section of the work considers the grounds for possible review of the decision of the courts with the participation of jurors in the order of Art. 401.6 of the Code of Criminal Procedure and grounds proposed by the Plenum of the RF Supreme Court in the Decree of January 28, 2014. The fourth section of the work is devoted to the characteristics of the rules and procedure of Supervisory proceedings, specifies the types of appealed decisions, powers and limits of the rights of the Presidium of the Russian armed forces, provides examples of review of judicial decisions with the participation of juries that have en-tered into force.Conclusions. The author suggests to replace the grounds for cancellation or amendment of acquittal decisions of courts based on the jury’s decision with the grounds of cassation review of jury trials that are included in art. 664 and 665 of the Code of Criminal Procedure of the Republic of Kazakhstan due to their clearer legal definition and lack of evaluative concepts.