bluuebunny/crossref_metadata_2025_split huggingface dataset:
TNP-470 skews DC differentiation to Th1-stimulatory phenotypes and can serve as a novel adjuvant in a cancer vaccine
Authors: Ho Derek Hoi-Hang , Wong Roger Hoi-Fung 
Published: July 2018

Key PointsTNP-470 skews DC differentiation to a phenotype with Th1-stimulatory features. TNP-470–treated DC vaccine protects mice from tumors by tumor-specific immunogenicity induction in prophylactic and therapeutic settings.
A Phase 1 trial of autologous monocytes stimulated ex vivo with Sylatron® (Peginterferon alfa-2b) and Actimmune® (Interferon gamma-1b) for intra-peritoneal administration in recurrent ovarian cancer
Authors: Green Daniel S. , Nunes Ana T. , David-Ocampo Virginia , Ekwede Irene B. , Houston Nicole D. , Highfill Steven L. , Khuu Hanh , Stroncek David F. , Steinberg Seth M. , Zoon Kathryn C. , Annunziata Christina M. 
Published: July 2018

Abstract
Background
Ovarian cancer has no definitive second line therapeutic options, and largely recurs in the peritoneal cavity. Locoregional immune therapy using both interferons and monocytes can be used as a novel approach. Interferons have both cytostatic and cytotoxic properties, while monocytes stimulated with interferons have potent cytotoxic properties. Due to the highly immune suppressive properties of ovarian cancer, ex vivo stimulation of autologous patient monocytes with interferons and infusion of all three agents intraperitoneally (IP) can provide a strong pro-inflammatory environment at the site of disease to kill malignant cells.

Methods
Patient monocytes are isolated through counterflow elutriation and stimulated ex vivo with interferons and infused IP through a semi-permanent catheter. We have designed a standard 3 + 3 dose escalation study to explore the highest tolerated dose of interferons and monocytes infused IP in patients with chemotherapy resistant ovarian cancer. Secondary outcome measurements of changes in the peripheral blood immune compartment and plasma cytokines will be studied for correlations of response.

Discussion
We have developed a novel immunotherapy focused on the innate immune system for the treatment of ovarian cancer. We have combined the use of autologous monocytes and interferons alpha and gamma for local–regional administration directly into the peritoneal cavity. This therapy is highly unique in that it is the first study of its type using only components of the innate immune system for the locoregional delivery consisting of autologous monocytes and dual interferons alpha and gamma.
Trial Registration ClinicalTrials.gov Identifier: NCT02948426, registered on October 28, 2016. https://clinicaltrials.gov/ct2/show/NCT02948426
CrashSafe: a formal model for proving crash-safety of Android applications
Authors: Khan Wilayat , Ullah Habib , Ahmad Aakash , Sultan Khalid , Alzahrani Abdullah J. , Khan Sultan Daud , Alhumaid Mohammad , Abdulaziz Sultan 
Published: July 2018

AbstractEach software application running on Android powered devices consists of application components that communicate with each other to support application’s functionality for enhanced user experience of mobile computing. Application components inside Android system communicate with each other using inter-component communication mechanism based on messages called intents. An android application crashes if it invokes an intent that can not be received by (or resolved to) any application on the device. Application crashes represent a severe fault that relates to compromised users’ experience, consequently resulting in decreased ratings, usage trends and revenues for such applications. To address this issue—by formally proving crash-safety property of Android applications—we have defined a formal model of Android inter-component communication using Coq theorem prover. The mathematical model defined in theorem prover allows one to prove the properties of inter-component communication system and check the correctness of the proof in an automated way. To demonstrate the significance of the formal model developed, we carried proof of crash-safety of Android applications using Coq tool. The proposed solution named supports a formal approach that enables one to (i) check the correctness of inter-component communication in Android systems and (ii) establish a formal foundation for other tools to assess Android applications’ reliability and safety.
Viral antigens detectable in CSF exosomes from patients with retrovirus associated neurologic disease: functional role of exosomes
Authors: Anderson Monique R. , Pleet Michelle L. , Enose‐Akahata Yoshimi , Erickson James , Monaco Maria Chiara , Akpamagbo Yao , Velluci Ashley , Tanaka Yuetsu , Azodi Shila , Lepene Ben , Jones Jennifer , Kashanchi Fatah , Jacobson Steven 
Published: July 2018

AbstractBackgroundHTLV‐1 infects over 20 million people worldwide and causes a progressive neuroinflammatory disorder in a subset of infected individuals called HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). The detection of HTLV‐1 specific T cells in the cerebrospinal fluid (CSF) suggests this disease is immunopathologically mediated and that it may be driven by viral antigens. Exosomes are microvesicles originating from the endosomal compartment that are shed into the extracellular space by various cell types. It is now understood that several viruses take advantage of this mode of intercellular communication for packaging of viral components as well. We sought to understand if this is the case in HTLV‐1 infection, and specifically if HTLV‐1 proteins can be found in the CSF of HAM/TSP patients where we know free virus is absent, and furthermore, if exosomes containing HTLV‐1 Tax have functional consequences.ResultsExosomes that were positive for HTLV‐1 Tax by Western blot were isolated from HAM/TSP patient PBMCs (25/36) in ex vivo cultures by trapping exosomes from culture supernatants. HTLV‐1 seronegative PBMCs did not have exosomes with Tax (0/12), (Fisher exact test, p = 0.0001). We were able to observe HAM/TSP patient CSF (12/20) containing Tax+ exosomes but not in HTLV‐1 seronegative MS donors (0/5), despite the absence of viral detection in the CSF supernatant (Fisher exact test p = 0.0391). Furthermore, exosomes cultivated from HAM/TSP PBMCs were capable of sensitizing target cells for HTLV‐1 specific CTL lysis.ConclusionCumulatively, these results show that there are HTLV‐1 proteins present in exosomes found in virus‐free CSF. HAM/TSP PBMCs, particularly CD4+CD25+ T cells, can excrete these exosomes containing HTLV‐1 Tax and may be a source of the exosomes found in patient CSF. Importantly, these exosomes are capable of sensitizing an HTLV‐1 specific immune response, suggesting that they may play a role in the immunopathology observed in HAM/TSP. Given the infiltration of HTLV‐1 Tax‐specific CTLs into the CNS of HAM/TSP patients, it is likely that exosomes may also contribute to the continuous activation and inflammation observed in HAM/TSP, and may suggest future targeted therapies in this disorder.
The ethos of Chinese capitalism: lessons from the career paths of Shanghai white-collar workers
Authors: Guiheux Gilles 
Published: July 2018

AbstractThis paper considers the issue of labor and labor regimes in China from a micro angle. It aims at identifying how individuals in today’s China relate to work and labor after the « thirty glorious years » of booming economic growth. The analysis of changing attitudes to work and labor takes up the notion of strategy, considering that individuals in a given social environment have the capacity to promote their own personal interests and take action to increase their gains or benefits. Listening to the discourse of a group of white-class workers, the Chinese capitalism ethos appears to be close to how social scientists have described Western capitalism, wherein employees are autonomous, flexible, creative and individualistic. At the same time, this survey shows that, beyond complying with this ethos, individuals are able to make choices. The white-collar workers we met set down clear requirements when it comes to choosing a job. Employment should advance their personal development, but should not be to the detriment of other aspects of their lives. In today’s China, while industrial workers are fighting for decent salaries after decades of marginalization, white-collar workers are also making new demands of their employees in terms of the quality of their jobs and lives.
Second-generation antipsychotics and metabolic side-effects: Canadian population-based study
Authors: Hirsch Lauren , Patten Scott B. , Bresee Lauren , Jette Nathalie , Pringsheim Tamara 
Published: July 2018

BackgroundUse of second-generation antipsychotics (SGA) has increased in recent years; however, their use and effect on metabolic outcomes has been poorly characterised in population-level studies.AimsThis study aimed to determine the associations between SGA use and metabolic indicators in a general population.MethodWe used data from the Canadian Health Measures Survey, a cross-sectional survey of Canadian households. Participants were Canadians aged 3–79 years, living in one of the ten provinces. Several metabolic indicators were examined, including weight, body mass index, waist circumference, hypertension, diabetes and two definitions of metabolic syndrome.ResultsThe proportion of Canadians taking an SGA tripled over the study period. SGA use was significantly associated with hypertension (odds ratio 1.94, 95% CI 1.07–3.55) and abdominal obesity in adults, as defined by the National Cholesterol Education Program–Adult Treatment Panel III (odds ratio 2.62, 95% CI 1.45–4.71).ConclusionsEvidence of metabolic dysfunction with SGAs is seen in the Canadian population, along with a rapid increase in prevalence of use since 2007.Declaration of interestNone.
PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain
Authors: Gutnik Silvia , Thomas Yann , Guo Yanwu , Stoecklin Janosch , Neagu Anca , Pintard Lionel , Merlet Jorge , Ciosk Rafal 
Published: July 2018

ABSTRACTThe Notch signalling pathway is a conserved and widespread signalling paradigm, and its misregulation has been implicated in numerous disorders, including cancer. The output of Notch signalling depends on the nuclear accumulation of the Notch receptor intracellular domain (ICD). Using the Caenorhabditis elegans germline, where GLP-1/Notch-mediated signalling is essential for maintaining stem cells, we monitored GLP-1 in vivo. We found that the nuclear enrichment of GLP-1 ICD is dynamic: while the ICD is enriched in germ cell nuclei during larval development, it is depleted from the nuclei in adult germlines. We found that this pattern depends on the ubiquitin proteolytic system and the splicing machinery and, identified the splicing factor PRP-19 as a candidate E3 ubiquitin ligase required for the nuclear depletion of GLP-1 ICD.
TMD symptoms and vertical mandibular symmetry in young adult orthodontic patients in North Sumatra, Indonesia: a cross-sectional study
Authors: Sofyanti Ervina , Boel Trelia , Soegiharto Benny , Auerkari Elza I. 
Published: July 2018

Background: Temporomandibular joint disorder (TMD) includes symptoms of pain and dysfunction in the muscles of mastication and the temporomandibular joint. Differences in vertical condylar height, observed in the assessment of mandibular asymmetry, is a structural alteration that represents a risk factor for TMD. The study aimed to evaluate the association between TMD symptoms and vertical mandibular symmetry in young adult orthodontic patients in North Sumatra, Indonesia. Methods: The cross-sectional study included 18-25-year-old (mean ± SD, 21.9 ± 2.0 years) old orthodontic patients admitted to the Dental Hospital of Universitas Sumatera Utara, Medan, between June 2016 and March 2017. Vertical mandibular asymmetry was assessed from all 106 subjects using Kjellberg’s technique from pre-treatment panoramic radiographs. The TMD symptoms were assessed by structural interviews using modified questionnaires based on Temporomandibular Disorder Diagnostic Index and Fonseca’s Anamnestic Index. Results: Of the 106 subjects, 26 (24.5% of the total) with vertical mandibular symmetry and 39 (36.8%) with vertical mandibular asymmetry were positive for TMD symptoms. By contrast, 17 patients (16.0% of the total) with vertical condylar symmetry and 24 patients (22.6%) with vertical mandibular asymmetry were regarded negative for TMD symptoms. There was no significant difference (p=0.520) in TMD symptoms based on vertical mandibular symmetry. Conclusion: The results from this studied Sumatran population indicate that there are common TMD symptoms in young adult orthodontic patients, but there is no significant association between vertical mandibular asymmetry and TMD symptoms. Further study on the development of TMD, mandibular asymmetry and treatment planning for growing patients is suggested, using longitudinal and transitional approaches.
A nested randomised controlled trial of a newsletter and Post-it® note did not increase postal questionnaire response rates in a falls prevention trial
Authors: Rodgers Sara , Sbizzera Illary , Cockayne Sarah , Fairhurst Caroline , Lamb Sarah E. , Vernon Wesley , Watson Judith , Hewitt Catherine , Torgerson David J. 
Published: July 2018

Background: Attrition (i.e. when participants do not return the questionnaires) is a problem for many randomised controlled trials. The resultant loss of data leads to a reduction in statistical power and can lead to bias. The aim of this study was to assess whether a pre-notification newsletter and/or a handwritten or printed Post-it® note sticker, as a reminder, increased postal questionnaire response rates for participants of randomised controlled trials. Method: This study was a factorial trial embedded within a trial of a falls-prevention intervention among men and women aged ≥65 years under podiatric care. Participants were randomised into one of six groups: newsletter plus handwritten Post-it®; newsletter plus printed Post-it®; newsletter only; handwritten Post-it® only; printed Post-it® only; or no newsletter or Post-it®. The results were combined with those from previous embedded randomised controlled trials in a meta-analysis. Results: The 12-month response rate was 803/826 (97.2%) (newsletter 95.1%, no newsletter 99.3%, printed Post-it® 97.5%, handwritten Post-it® 97.1%, no Post-it® 97.1%). Pre-notification with a newsletter had a detrimental effect on response rates (adjusted odds ratio (OR), 0.14; 95% CI, 0.04 to 0.48; p<0.01) and time to return the questionnaire (adjusted hazard ratio, 0.86; 95% CI, 0.75 to 0.99; p=0.04). No other statistically significant differences were observed between the intervention groups on response rates, time to response, and the need for a reminder. Conclusions: Post-it® notes have been shown to be ineffective in three embedded trials, whereas the evidence for newsletter reminders is still uncertain.
Catástrofes e atuação militar: a subjetividade e a realidade traumática
Authors: Kegler Paula , Macedo Mônica Medeiros Kother 
Published: July 2018

A temática das catástrofes tem gerado preocupação em nível governamental e acadêmico. Diretrizes atuais ampliaram o papel das Forças Armadas Brasileiras na assistência às populações atingidas. Tal fato demonstra a importância de uma atitude reflexiva a respeito das complexidades envolvidas no trabalho das equipes militares de saúde no socorro disponibilizado às pessoas nestas situações críticas. Nesta perspectiva, este artigo teórico tem o objetivo de abordar a temática da atuação militar em seu exercício laboral, o qual tem no cuidado importante eixo de atuação. Assim, desde os aportes epistemológicos da Psicanálise, o conceito psicanalítico de trauma é utilizado para evocar os possíveis desdobramentos intrapsíquicos frente a vivências impactantes do sujeito na realidade material de uma tragédia. Estudos e reflexões a respeito desses efeitos psíquicos são pertinentes, especialmente em relação aos militares que exercem o cuidado como atividade princeps. Constatou-se que a ausência de espaço para a expressão de sofrimentos, decorrentes da imposição de uma performance profissional própria ao ambiente militarizado, pode se caracterizar como relevante causa de padecimentos psíquicos. Logo, a oferta de escuta ao sujeito trabalhador é um importante fator de promoção de cuidado direcionado, também, à saúde psíquica destes profissionais.
A (IR) RESPONSABILIDADE SOCIAL CORPORATIVA NO BRASIL: EMPRESAS, PODER E LAÇOS ENTRELAÇADOS
Authors: Costa Maria Alice Nunes , Borin Elaine 
Published: July 2018

Resumo: Este artigo tem como objetivo analisar as condutas empresariais socialmente irresponsáveis no Brasil. A irresponsabilidade das empresas foi denunciada por meio da “Operação Lava Jato”, iniciada em 2014, e ainda em curso no país. O foco deste artigo são as teias tecidas entre as empresas envolvidas, políticos e parlamentares no esquema de corrupção, em especial com grandes empresas empreiteiras, responsáveis pela infraestrutura do Brasil. Elas formavam um cartel para se associar a uma das maiores indústrias petroleiras do mundo, a Petrobras (Petróleo Brasileiro S.A.). Essa operação deflagrou um modus operandi histórico no Brasil em que demonstra a relação perniciosa entre o público e o privado no Brasil. A análise é baseada em um estudo de caso, com dados empíricos apresentados pelos órgãos federais responsáveis pela Operação Lava Jato, que se encontram disponíveis na internet e na imprensa brasileira. Este estudo analisa, portanto, os dados empíricos e os históricos sobre a natureza do modelo de capitalismo dos laços desenvolvidos no Brasil. Conclui-se que, quando uma sociedade possui uma tradição histórico-cultural permeada por estreitas relações privadas e patrimoniais entre governo e empresas, esse fato impacta negativamente no desempenho econômico e no capital reputacional de empresas e governo, ferindo consequentemente a adoção de um comportamento ético e de responsabilidade social corporativa.Palavras-chave: condutas empresariais; capitalismo de laços; responsabilidade social corporativa.Abstract: This article aims to analyze the socially irresponsible business conduct in Brazil. The irresponsibility of the companies was denounced through the "Operation Lava Jato", begun in 2014, and still in progress in the country. The focus of this article are the webs woven between the companies involved, politicians and parliamentarians in the corruption scheme, especially with large companies contractors, responsible for the infrastructure of Brazil. They formed a cartel to join one of the world's largest oil companies, Petrobras (Petróleo Brasileiro S.A.). This operation triggered a historical modus operandi in Brazil in which it demonstrates the pernicious relationship between the public and the private in Brazil. The analysis is based on a case study, with empirical data collected by the federal agencies responsible for Operation Lava Jato, which are available on the internet and in the Brazilian press. This case study therefore analyzes empirical and historical data on the nature of the capitalist model of the ties developed in Brazil. It is concluded that, when a society has a historical-cultural tradition permeated by close private and patrimonial relations between government and companies, this fact negatively impacts on the economic performance and reputational capital of companies and government, consequently hurting the adoption of ethical behavior and corporate social responsibility.Keywords: Business conduct. Capitalism of ties. Corporate social responsibility.
ADALIMUMAB DISCONTINUATION IN PATIENTS WITH RHEUMATOID ARTHRITIS AFTER ACHIEVING SUSTAINED REMISSION
Authors: Demidova N. V. , Galushko E. A. , Glukhova S. I. , Savushkina N. M. , Satybaldyev A. M. , Cherkasova M. V. , Khoroshko N. V. , Maglevanyi S. V. , Gordeev A. V. 
Published: July 2018

Objective: to assess whether adalimumab (AD) can be gradually discontinued during continuous methotrexate (MTX) use in patients with early rheumatoid arthritis (ERA).Subjects and methods. Within the REMARCA (the Russian study of methotrexate and biological agents in early active arthritis) study, the investigators examined 20 patients (17 women and 3 men; median age, 51 [41.5; 56] years) with ERA (disease duration, 10 [5.5; 20] months; DAS28, 5.17 [4.37; 6.51]; 85% of the patients were seropositive for rheumatoid factor and 85% for anti-cyclic citrullinated peptide antibodies.Results and discussion. All the patients received subcutaneous MTX 25 mg/week. Twelve weeks after beginning therapy with MTX, due to its inefficiency, ADA was added according to the standard scheme. At week 24, the median DAS28 was 3.0 [1.65; 3.73]; 85% of the patients achieved remission or low disease activity. After 3 months of ADA therapy, high or moderate disease activity remained in 3 (15%) patients; median DAS28 was 4.4 [4.3; 6.1]; the drug was discontinued in them due to ineffective therapy. After 12-month follow-up, low DAS28 scores were observed in 5 (29.4%), DAS28 remission was in 12 (70.6%) of the 17 patients who continued ADA treatment; after 24 months, all the 17 patients were noted to have remission. After achieving sustained remission (≥ 6-month duration during ADA therapy), there was a carefully controlled reduction (titration) in the dose of ADA with its complete discontinuation, by maintaining remission at 36-month follow-up; the median DAS28 was 1.6 [1.4; 2.2]. During ADA treatment, one female patient developed pustular psoriasis and therefore the drug was discontinued at 24-month follow-up during the period of sustained remission. Other serious adverse events and tuberculosis cases were not recorded.Conclusion. Thus, the results of the study are indicative of the high clinical efficiency of the therapy. After ADA discontinuation, sustained remission can be maintained in patients with ERA and if they took biological agents early.