bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galactorrhea and hyperprolactinemia during vortioxetine use: case report
Authors: Ozkan Huseyin Murat 
Published: July 2018

Abstract

Background:
Hyperprolactinemia is one of the most common endocrine disorders of the hypothalamic-pituitary axis. Hyperprolactinemia and galactorrhea are rarely seen as adverse effects of antidepressant drugs.

Case presentation:
Thirty-three years old women, between 2011 and 2017, three depressive episodes were observed. Initially, fluoxetine was used, no galactorrhea was detected. Secondly, she was given escitalopram and visited the clinic with amenorrhea and galactorrhea. Her serum prolactin levels were 50.88 ng/mL and MRI findings were normal. Escitalopram was discontinued and prescribed cabergoline and then prolactin levels were 16.56 ng/mL in the third month. During the vortioxetine treatment, she developed galactorrhea and prolactin level was 43.65 ng/mL. Vortioxetine was discontinued and it was measured at 20.14 ng/mL after 4 weeks of drug-free observation.

Conclusion:
Vortioxetine is a multimodal agent that modulates a select population of 5-HT receptors. To literature, there was no case presentation of galactorrhea observed during the use of vortioxetine. Galactorrhea associated with SSRIs are limited to case presentations. Antidepressants are thought to cause galactorrhea through tuberoinfundibular dopaminergic neurons or postsynaptic serotonergic neurons in the hypothalamus. When galactorrhea was observed during antidepressant drug use, prolactin levels and MRI should be investigated, and termination/replacement of antidepressant treatment is recommended if necessary.
Myocarditis case associated with Campylobacter jejuni
Authors: Ayyildiz Hakan , Kalayci Mehmet , Cinkilinc Nadire , Bozkurt Mahmut , Karadag Makbule Kutlu 
Published: July 2018

Abstract

Objective
Myocarditis is an inflammatory disease of the heart caused by various agents and especially enteroviruses, and it is difficult to diagnose and treat. Myocarditis is rarely associated with bacterial infections. Although the most common bacterial infections are Salmonella spp. and Shigella spp., extremely rare cases of Myocarditis due to Campylobacter jejuni are also reported.

Patient and methods
A 17-year-old male patient with no previous chronic illness was admitted to our emergency department with complaints of abdominal pain, diarrhea, vomiting, and chest pain. He stated that symptoms began after eating a chicken burger a few days ago.

Results
In the laboratory tests performed, CK-MB and high sensitive Troponin I values were determined as 33.8 IU/L and 1816 ng/L, respectively. Electrocardiogram results revealed left axis left anterior hemiblock in the normal sinus rhythm as well as a ST-T change in the inferior and lateral derivations. Campylobacter jejuni was detected in the stool sample of the patient.

Conclusion
Myocarditis is one of the rare complications of C. jejuni infection. Bacterial myocarditis should be considered when troponin and cardiac enzymes are elevated in patients admitted to the emergency department with diarrhea and chest pain.
Characterization of Tandem Airfoil Configurations of Axial Compressors
Authors: M P Manas , S R Shine 
Published: July 2018

Abstract
The objective of the current study is to investigate the effects of geometric parameters on the fluid flow patterns, diffusion factor, load-split, and off-design performance of the tandem configuration under subsonic, rectilinear, cascade flow. A 2-D computational model using finite volume formulation has been developed and validated against available experimental data. The obtained data is presented in a format involving loss parameter and loading and will help the designer to have sufficient number of combinations within the useful range of application. It is observed that general performance behavior of tandem cascade is similar to a single airfoil data. Load shifting from the front airfoil to the rear airfoil is noted at positive axial overlaps and higher camber ratios. An optimum gap ratio of around 2 is observed for the range of configurations investigated. Contrary to the previous literature, the present study indicates higher loading of the front airfoil for the best overall loading-to-loss ratio of the tandem configuration.
π-Electron delocalization in 2-benzoyl-5-phenylpyrazolidin-3-one
Authors: Olesiejuk Monika , Kudelko Agnieszka , Gajda Katarzyna , Dziuk Błażej , Ejsmont Krzysztof 
Published: July 2018

Abstract
The crystal and molecular structures of 2-benzoyl-5-phenylpyrazolidin-3-one have been characterized by X-ray diffraction along with density functional theory studies. Cinnamic acid chloride was reacted with benzhydrazide, yielding 2-benzoyl-5-phenylpyrazolidin-3-one. This product was formed in the transformation comprising the nucleophilic addition of benzhydrazide to the styryl fragment of the α,β-unsaturated arrangement and subsequent cyclization. The molecule contains two benzene rings and one five-membered heterocyclic ring with an N–N single bond. The five-membered ring is composed of three atoms of sp
3 hybridization and two atoms of sp
2 hybridization, which cause the flattening of the heterocyclic ring. The Harmonic Oscillator Model of Aromaticity and Nucleus-Independent Chemical Shift indexes, calculated for the benzene rings, demonstrate that there are no substantial interactions between the regions of π-electron delocalization in the molecule. In the crystal structure, there are N–H···O hydrogen bonds that link the molecules along the crystallographic c axis and weak intermolecular C–H···O hydrogen bonds.
Molecular Dynamics Simulations of Water, Silica, and Aqueous Mixtures in Bulk and Confinement
Authors: Geske Julian , Harrach Michael , Heckmann Lotta , Horstmann Robin , Klameth Felix , Müller Niels , Pafong Elvira , Wohlfromm Timothy , Drossel Barbara , Vogel Michael 
Published: July 2018

Abstract
Aqueous systems are omnipresent in nature and technology. They show complex behaviors, which often originate in the existence of hydrogen-bond networks. Prominent examples are the anomalies of water and the non-ideal behaviors of aqueous solutions. The phenomenology becomes even richer when aqueous liquids are subject to confinement. To this day, many properties of water and its mixtures, in particular, under confinement, are not understood. In recent years, molecular dynamics simulations developed into a powerful tool to improve our knowledge in this field. Here, our simulation results for water and aqueous mixtures in the bulk and in various confinements are reviewed and some new simulation data are added to improve our knowledge about the role of interfaces. Moreover, findings for water are compared with results for silica, exploiting that both systems form tetrahedral networks.
Searching for a Fresh Point of View
Authors: Bombola Gina 
Published: July 2018

In the early 1940s Aaron Copland cultivated an identity as an authority on film composition through public lectures, interviews, and his own film scores. Championing film music’s potential as a serious art form, Copland sought to show Hollywood that film composers could branch out from the romantic and post-romantic aesthetics that infused contemporary soundtracks and write in a more modern, even American, style. During the 1940s the film industry was already embracing an abundance of new production styles, techniques, and genres that fostered innovation in the development of cinematic musical codes. When Copland returned to Hollywood in 1948 to score William Wyler’s psychological melodrama The Heiress (1949), he chose to take on a set of new challenges. Copland attempted to discover a new idiom for love music, on the one hand, and began to use leitmotifs as a structural device, on the other.
Copland’s experience with The Heiress opens a space in which to reassess his opinions about appropriate film-scoring techniques as well as his public endorsement of film composition. His perspectives on film composition—as demonstrated in his writings, correspondence, and film scores as well as in interviews and reviews of his film music—reveal a tension between the composer’s artistic sensibilities and his attitude toward the commercialism of film music. Indeed he maintained a more ambivalent attitude toward cinematic composition than he publically professed. Understood in this context, Copland’s scoring decisions in The Heiress reflect a turn away from the Americana of Rodeo (1942) and Appalachian Spring (1944) and the Russian-themed score of The North Star (1943), as he sought to refashion his identity as a composer in the post-war years.
N-TERMINAL PROPEPTIDE OF COLLAGEN TYPE III AS A PROPOSED MARKER OF MYOCARDIAL FIBROSIS IN TYPE 2 DIABETES
Authors: Drapkina O. M. , Gegenava B. B. 
Published: July 2018

Aim. To evaluate the role of N-terminal procollagen type III propeptide (P3NP) as a proposed marker of myocardial fibrosis in type 2 diabetes (DM2) patients.Material and methods. In the study, 2 groups of patients participated: with DM2 and non-DM2 (both n=32). All patients underwent clinical and laboratory assessment, including P3NP, electrocardiography, echocardiography. Statistics was done with Mann-Whitney criteria and Spearman correlation.Results. The level P3NP is significantly higher in DM2 patients (р<0,00001). In DM2 patients, the level of P3NP significantly correlates with increased myocardial mass of the left ventricle (р=0,00026) and myocardial mass index of the left ventricle (р=0,03685).Conclusion. Echo- and electrocardiographic signs characteristic for myocardial fibrosis (mass increase, voltage decline) in DM2 patients are concomitant with the increase of P3NP. Significant correlation of P3NP and the size of myocardium makes it to propose P3NP as one of possible markers of myocardial fibrosis in DM2 persons.
OPPORTUNITIES FOR EARLY OUTPATIENT DIAGNOSTICS OF OBSTRUCTIVE SLEEP DISORDERED BREATHING
Authors: Larina V. N. , Mironova T. N. , Elfimova E. M. , Alekseeva T. A. , Starostin I. V. , Sidorova V. P. , Litvin A. Yu. 
Published: July 2018

Aim. To evaluate the prevalence of possible obstructive respiratory disorder during sleep in outpatients by the data from computed monitoring pulse oxymetry (CPO) and questionnaires.Material and methods. To the open one stage non-randomized comparative study, 175 patients included: 37,1% males, 62,9% females, age 55,1±11,1 y.o., visiting a clinician office at outpatient facility. Sleep disordered breathing of obstructive origin was diagnosed with a survey, modified Stradling questionnaire and CPO; and excessive daytime sleepiness — with Epworth score. For confirmation of obstructive sleep apnea (OSA), a bifunctional monitoring was performed (BM) with further comparison of the data with CPO results.Results. Chronic hypoxemia at night by CPO was found in 71,4% patients, and probability of OSA moderate and severe — in 42,8% patients. By the modified Stradling, OSA was predicted in 57,7%, by Epworth, the daytime sleepiness was found in 11,4%. Mild OSA in BM was found in 8,9%, moderate — 14,7%, severe — 20,6%. The data from CPO matched with BM in 80% patients. Sensitivity of CPO for nocturnal hypoxemia of various severity was 92,4%, specificity — 76,4%; sensitivity of the Stradling questionnaire — 88,9%, specificity — 88,2%. Sensitivity of Epworth score — 27,8%, specificity — 82,4%.Conclusion. Chronic nocturnal hypoxemia was found in 71,4%, and probability of moderate and severe OSA — in 42,8% in outpatients with internal diseases profile. CPO and Stradling questionnaire can be applied as diagnostic instruments for OSA at outpatient stage.
DYNAMICS OF CARDIOVASCULAR RISK FACTORS IN RAILWAY CREWS
Authors: Kazidaeva E. N. , Sergunina I. N. , Venevtseva Yu. L. 
Published: July 2018

Aim. To assess the prevalence of cardiovascular risk factors (RF) and dynamics over 4 years in locomotory crews.Material and methods. One hundred train drivers and assistants aged 25-59 y.o. (mean age — 43,8±10,3 y.) were investigated in-patient with 24 hour blood pressure (BP) monitoring, ultrasound Doppler of brachiocephalic arteries, standard biochemistry. Fifty three persons were assessed prospectively from 2013 to 2017 y.Results. BP increase (essential hypertension of I-II grades with mild or moderate hypertension) was found in 78 persons, with the mean duration — 10,4±4,3 years, and age of onset — 37,0±8,5 y.o. Most commonly, the dyslipidemiaswerefound:hypertriglyceridemiain59%,hypercholesterolemia in 44%. Smokers — 39%, overweight — 37%, obese — 41%. Correlational analysis revealed significant direct correlation of triglycerides with body mass index (r=0,35), with glucose tolerance disorder (r=0,22) and hypertension (r=0,22), however there was negative correlation with smoking status (r=-0,25). In patients with hypertension, aged 25-39 (n=18), comparing to the group with the none (n=22), there were significantly higher: body mass index, cholesterol level, triglycerides level and low density lipoproteideslevelwiththeabsenceofdifferenceinhighdensitylipoproteides, smoking prevalence and family anamnesis of cardiovascular diseases. In prospective follow-up the negative dynamics of lipid profile was found in males of 25-39 y.o., and morphological presentation — lesions in brachiocephalic arteries, at the age 40-49 y. with stabilization of parameters at the age 50-59 y.o. Mean group levels of systolic and diastolic BP at daytime and at night in both timepoints were within normotension range in all groups, corresponding to “non-dipper” type.Conclusion. Most prevalent RF in railway crews were dyslipidemia and obesity. The adequacy of therapy prescribed in all age strata makes it to regard the raise of BP as modifiable RF.
The Whole World is Becoming Science Studies: Fadhila Mazanderani Talks with Bruno Latour
Authors: Mazanderani Fadhila , Latour Bruno 
Published: July 2018

How to survive in this forest? How to keep it alive? Latour poses these questions in relation to the current global ecological crisis; but they are equally apt when applied to the “forest”––or to use Latour’s own metaphor, “biodiversity”––of STS. In his interview, Latour puts forward a particular vision for STS’s survival; a vision of STS as neither critical of nor ancillary to science, but where a tacit STS sensibility becomes integrated into science through education and collaboration. While Latour acknowledges the many differences of attitude and approach within STS, he also glosses over them, foregrounding as the defining feature of all those “infected” with STS the shared commitment to transforming science with the big “S” into something that can be studied empirically. The picture he paints is, unsurprisingly, a constructivist one, in which social and natural scientists, engineers, artists and politicians, “build worlds” together. A reflection by Fadhila Mazanderani follows the interview.
Discussões Envolvendo a Semipresencialidade na Formação do Professor de Física
Authors: Rosa Cleice T. Werner da , Vieira Bianca Stéfani , Dos Santos Antonio Vanderlei 
Published: July 2018

O presente estudo investiga uma disciplina curricular operacionalizada na modalidade semipresencial, avaliando sua pertinência de acordo com os atores envolvidos. O foco centra-se na análise da percepção do professor e dos acadêmicos da disciplina e justifica-se pelo fato de que, ao mesmo tempo que essa modalidade se revela uma comodidade para os alunos, tem apresentado entraves que limitam sua utilização. A disciplina escolhida para análise apresenta 50% de sua carga horária em atividades na modalidade semipresencial e recorre à plataforma Moodle para desenvolver tais atividades. Para a coleta dos dados, utilizou-se entrevista semiestruturada com o professor da disciplina, além de questionário com os alunos que já cursaram a disciplina. Como resultado, o estudo apontou que, na percepção do professor, a modalidade se revela com dificuldade para os alunos que não têm o hábito de acessar os materiais no tempo correto e se mostram desorganizados para realizar as atividades. Em termos dos alunos, o estudo identificou que grande parte dos alunos tem familiaridade com o computador, mas que o uso da plataforma Moodle se mostra uma dificuldade nesse tipo de modalidade. Além disso, os alunos apontam problemas operacionais com a plataforma e a falta da presença do professor para auxiliar.Palavras-chave: Ensino semipresencial, Física, Formação de professores. Discussions Involving Semipresenciality in Physical Teacher TrainingAbstractThe present study investigates a curricular discipline operationalized in a blended learning modality, evaluating its potentiality and challenges. The focus is the analyze of the teachers perception and of the disciplines academics and it is justified by the fact that, in the same time as the modality reveals to be a convenience to the students, it has presented hindrances that limit its use. The discipline chosen to be analyzed presents 50% of the workload in activities in blended learning mode and resort to the Moodle platform to develop such activities. For data collection, was used an half structured interview with the disciplines teacher and a quiz with the students that had already attended the discipline. As a result, the study points that in the teachers perception the modality reveals to be difficult to students that dont have the habit to access the materials in the correct time and show to be unorganized to realize the activities. In terms of the students, the study identified that most of the students have familiarity with the computer, but the use of Moodle Platform shows to be a difficulty in this type of modality. Besides that, students point a operational problem with the platform and the lack of presence of the teacher to help.Keywords: Blended learning, Physical, Teachers formation.
U Şekilli Betonarme Perdelerin Farklı Yatay Yük Etkileri Altında Doğrusal Olmayan Davranışı
Authors: ÇOLAKOĞLU Halit Erdem 
Published: July 2018

Betonarme perde elemanlarının kayma
merkezlerinin belirlenmesi uygulanan kuvvetin kesitte burulma oluşturmadan sadece
eğilme meydana getirmesi bakımından önemlidir. Deprem bölgelerinde gerek
yapının güvenliğini sağlamak gerekse yer değiştirmeleri sınırlandırarak yapısal
olmayan elemanlarda meydana gelecek hasarları azaltmak için perde elemanlara etkiyen yatay yüklerin
perdenin kayma merkezlerinden
uygulanması burulma etkisini ortadan kaldırması bakımından önemlidir. Bu
çalışmada U kesitli betonarme perdenin, farklı
yatay yük etkileri altında doğrusal olmayan analizleri yapılarak, kayma merkezlerinin nonlineer değişimi
araştırılmıştır.
Rejecting Religious Intolerance in South-East Asia
Authors: Rogers Benedict 
Published: July 2018

This article is going to discuss religious intolerance in Myanmar and Indonesia. Religious intolerance in these two countriesis driven by extreme ideologies which reject tolerance and diversity. These ideologies influence society and generate a culture of discrimination. In Myanmar, Muslims and Christians face a campaign of hatred led by a militant ultra-nationalist Buddhist movement which has resulted in several outbreaks of violence in the past five years. The predominantly Muslim Rohingya people have been the most severely victimized, enduring grave human rights violations which some international experts describe as ‘ethnic cleansing’, ‘crimes against humanity’ and potentially genocide.In Indonesia, a country with a tradition of religious tolerance, radical Islamism has become an increasing threat to non-Sunni Muslim minorities, particularly the Ahmadiyya and Shi’a communities, as well as Christians and other religions and to Sunni moderates who work to preserve Indonesia’s pluralism. To challenge the pervasive influence of intolerance, a variety of imaginative strategies are necessary.Recommendations will call state actors, media and civil society to work together to combat hate speech narratives through all available channels: education, the judiciary, campaigning platforms, the media, legislation and international diplomacy.
Estratégia como prática para o enfrentamento da crise hídrica: Um olhar para os praticantes
Authors: Cruz Ivan Fernandes da , Carmo Luana Jéssica Oliveira , Ribeiro João Eduardo , Assis Lilian Bambirra de 
Published: July 2018

O objetivo deste artigo é analisar, por meio de um estudo de caso, as estratégias implementadas pelos praticantes na Usina Hidrelétrica de Energia (UHE) Três Marias durante o período de agravamento da crise hídrica, sob a ótica da estratégia como prática. Para tanto, coube explanar sobre o conceito de estratégia como prática e seus elementos: prática, práxis e praticantes no referencial teórico. O trabalho se constitui em um estudo de caso feito na Usina Hidrelétrica de Energia (UHE) Três Marias, localizada no Estado de Minas Gerais. Para a coleta de dados foram feitas entrevistas semiestruturadas. Obteve-se acesso a documentos como relatórios que também foram úteis à análise. Dentre os principais resultados verifica-se o relacionamento entre as ações implementadas e a teoria analisada, destacando os elementos da estratégia como prática. Além disso, percebeu-se que a tomada de decisão coletiva, a práxis, representou um atraso para as ações de enfrentamento da crise hídrica devido a interesses divergentes dos praticantes.
Protective Effects of Catechins Isolate From GMB4 Clone Green Tea Against EPC In Type 2 Diabetes Mellitus
Authors: Peristiowati Yuly 
Published: July 2018

Introduction : This study aimed to evaluate the role of catechins isolates from GMB4 clone green to in the dynamics of endothelial progenitor cells (EPC) in type 2 diabetes mellitus (DM).Methods: 25 Wistar rats, were divided into 5 groups, including control group, type 2 diabetes mellitus group, treated daily administration of extracts of catechins isolate from GMB4 clones green tea at 20; 40; and 60 mg /kgBB doses for 6 weeks. EPCs analysis was performed by flow cytometry,levels of NO was performed using a spectrophotometer, serum levels of SDF-1a was performed with ELISA technique. Analysis of the expression of SDF-1 and CXCR-4 was performed using immunohistochemistry techniques.Results : The CD34+ and CD133+ count is lower in the DM group compared to the control group (P < 0.05). Of the three doses of catechins, only the highest dose were able to significantly increase CD34+ count compared to rats in the diabetes mellitus group (P < 0.05), Serum NO level is significantly higher in the DM the control group (P < 0.05). All three doses of catechins were able to significantly increase the expression of SDF-1a and CXCR4 in the aorta compared to the DM group or the control group (P < 0.05).Discussion : It can be concluded that high dose cathecin isolate from GMB-4 clone green tea (60 mg/kgBB) may trigger the proliferation and maturation of EPCs in rats with type 2 DM in environment with high level of NO, involving the interacton between SDF-1a and CXCR4 in the aorta.