bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing real-world evidence in pharmacoeconomics: A comprehensive review
Authors: Bhatia Nitish 
Published: November 2024

Abstract
Real-world evidence (RWE) is increasingly recognized as a valuable resource in pharmacoeconomics, offering insights into the effectiveness, safety, and economic impact of healthcare interventions in routine clinical settings. This review highlights the growing significance of RWE beyond traditional clinical trials, focusing on its applications in healthcare decision-making. Key sources of RWE, such as electronic health records, claims data, registries, and observational studies, are explored alongside methodologies like retrospective cohort studies, case–control studies, and comparative effectiveness research. The review examines RWE’s role in assessing treatment effectiveness, estimating healthcare costs, evaluating long-term outcomes, and informing health technology assessments and reimbursement decisions. Challenges such as data quality, confounding factors, and generalizability are discussed with strategies for overcoming these limitations. Regulatory perspectives from agencies like the Food and Drug Administration and European Medicines Agency, as well as ethical and privacy considerations are also reviewed. Emerging trends, such as the integration of artificial intelligence and patient-generated data, offer new opportunities for enhancing the use of RWE in healthcare. The findings emphasize the importance of leveraging RWE to improve healthcare delivery, optimize resource allocation, and support value-based decision-making.
Simulation of modern and future climate by INM-CM6M
Authors: Gritsun Andrey S. , Volodin Evgeny M. , Bragina Vasilisa V. , Tarasevich Maria A. 
Published: November 2024

Abstract
The paper considers the results of climate change modelling for 1850–2100 using the INM-CM6M climate model of the Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences. The calculations were performed according to the CMIP6 protocol for modelling the present-day climate for the period from 1850 to 2014 and the IPCC scenarios SSP1-2.6, SSP2-4.5, SSP3-7.0 and SSP5-8.5 of anthropogenic forcing changes in 2015–2100. We analyse changes in such characteristics of the climate system as global mean near-surface temperature, spatial distributions of near-surface temperature, precipitation, sea level pressure, and radiative forcing characteristics in comparison with observational data and results obtained with the previous (INM-CM5) version of the model. We conclude that the new version of the model is superior to the previous one in terms of the quality of simulation of the observed climate and its changes in 1960–2022. The amplitude of global warming predicted by the INM-CM6M for moderate IPCC scenarios is close to the average value of the CMIP6 model ensemble, and for severe scenarios it is closer to the upper limit of its range. For the SSP3-7.0 and SSP5-8.5 scenarios, INM-CM6M predicts a complete loss of Arctic sea ice in summer. As the rate of global warming increases, so does the amplitude and duration of extreme weather and climate events.
Planetary boundary layer scheme in the INMCM Earth system model
Authors: Mortikov Evgeny V. , Debolskiy Andrey V. , Glazunov Andrey V. , Chechin Dmitry G. , Shestakova Anna A. , Suiazova Victoria I. , Gladskikh Daria S. 
Published: November 2024

Abstract
The paper reviews the planetary boundary layer parameterizations in the current generation of the INMCM Earth system model. We discuss some of the challenges and improvements necessary to correctly reproduce the essential non-linear interactions of physical processes common to the boundary-layer physics. Overview of some of the improvements implemented in the PBL single-column version of the INMCM model is presented. These include the hierarchy of turbulence closures of different computational complexity suited for modelling a thin stable boundary layer. The closures are based on a consistent definition of the first-order, single- and two-equation approaches and inclusion of stability functions in the surface layer parameterizations tailored for strong static stability of the atmosphere.
Land surface scheme TerM: the model formulation, code architecture and applications
Authors: Stepanenko Victor M. , Medvedev Alexander I. , Yu. Bogomolov Vasiliy , Shangareeva Sumbel K. , Ryazanova Anna A. , Faykin Georgiy M. , Ryzhova Irina M. , Suiazova Victoria I. , Debolskiy Andrey V. , Chernenkov Alexey Yu. 
Published: November 2024

Abstract
This paper presents the INM RAS–MSU land surface scheme, extracted from the INM RAS Earth system model into an independent software complex and supplemented with several modules to reproduce new components and processes of the Earth system. The resulting software product is referred to as TerM (Terrestrial Model). The physical and mathematical foundations of the model, the main features of the software implementation, and examples of applications in reproducing components of the terrestrial hydrological and carbon cycles are briefly outlined. Separating the land surface block into a standalone software complex significantly saves computational resources when assessing the impact of global and regional climate changes on natural resources (including hydrological ones), ecosystem dynamics, and emissions of climate-relevant substances with high spatial detalization. Within the TerM modelling complex, the development, validation, and calibration of new parameterizations of physical and biogeochemical processes are being conducted in an autonomous mode for subsequent implementation into the full INM RAS Earth system model.
Computational framework for the Earth system modelling and the INM-CM6 climate model implemented on its base
Authors: Volodin Evgeny M. , Blagodatskikh Dmitry V. , Bragina Vasilisa V. , Chernenkov Alexey Yu. , Chernov Ilya A. , Ezhkova Alisa A. , Fadeev Rostislav Yu. , Gritsun Andrey S. , Iakovlev Nikolay G. , Kostrykin Sergey V. , Onoprienko Vladimir A. , Petrov Sergey S. , Tarasevich Maria A. , Tsybulin Ivan V. 
Published: November 2024

Abstract
In this paper, we present the current stage of development of the INM-CM Earth system model family by the Marchuk Institute of Numerical Mathematics of the Russian Academy of Sciences. The major change from the previous model version INM-CM5 is a new computational platform for the Earth System modelling. We describe the main parts of this digital platform, such as ocean-atmosphere coupling, version control, compilation/configuration, and automated testing subsystems. We also discuss major modifications of the physical parts of the climate model whereby the model simulations of observed climate were significantly improved as well as the model computational performance.
Psych construction types in Arabic as root-based in templatic morphosyntax
Authors: Fassi Fehri Abdelkader 
Published: November 2024

Abstract
We motivate the view that Arabic psych construction types originate as root phrases, devoid of categorial specifications, rather than verbal phrases, as commonly assumed. It is shown that roots are categorially and ontologically flexible, and that valency affixes are arguably roots, not categorical templates. Furthermore, the root/template divide, as defended by many authors, can only be construed as morphonological, once implemented in Distributed Morphology, rather than morphosyntactic. One advantage of our approach over the category (or vP) based approach is that it can apply on equal bases to all categories alike, because roots are acategorial, and psych expressions are not limited only to verb phrases. This is supported cross-linguistically by the existence of psych nominals or adjectives that have no verbal source. More motivation for the root hypothesis comes the root ontological flexibility, their complexity in valency increasing or decreasing morphosyntactic alternations, as well as from investigating adicity limitations on psych nominals, compared to those of psych (causative) verbs.
Compensator based improved model predictive control for Aero-engine
Authors: Pang Shuwei , Wang Tao , Cong Jingmei , Chen Hongyi , Li Qiuhong , Zhou Wenxiang , Fu Xueting 
Published: November 2024

Abstract
Model predictive control (MPC) can be applied to aero-engine for optimal command tracking and constraint handling. However, the performance of MPC is highly dependent on the accuracy of the predictive model. Therefore, a new structure MPC with an additional modeling error compensation loop is proposed, which can substantially reduce the dependence of MPC on the accuracy of the predictive model, and enhance the performance and real-time property of the system simultaneously. The new MPC replaces the traditional feedback correction loop with a compensation control loop to realize high-performance tracking over the large envelope with only one predictive model. The compensation loop controller employs an augmented discrete linear quadratic method for robust tracking capability. Simulations on the turboprop engine show that, compared with the standard MPC, the new MPC shows greater robustness over the envelope with smaller settling time, overshoot, and fluctuation of power turbine speed.
SEMEANDO AUTONOMIA E RESITÊNCIAS COTIDIANAS NO PLANEJAMENTO COMUNITÁRIO: MULHERES CAMPONESAS E CUIDADORAS DO CONTESTADO – LAPA, PR
Authors: Pereira Iara Beatriz Falcade 
Published: November 2024

Este artigo aborda um recorte dos trabalhos de conclusão de graduação do curso de Arquitetura e Urbanismo pela Universidade Federal do Paraná (FALCADE-PEREIRA, 2019). As pesquisas foram realizadas em parceria com o Movimento dos/as Trabalhadores/as Rurais Sem Terra – MST do Paraná. Para este artigo temos como objetivo visibilizar o protagonismo das mulheres camponesas do Assentamento Contestado e as práticas do cuidado como mobilizadoras de estratégias comunitárias para a reprodução da vida e de planejamentos contra hegemônicos. Foram trazidos estudos e análises sobre o Plano de Desenvolvimento do Assentamento - PDA do Contestado, porém os elementos principais vêm da realidade desse território por meio de narrativas de 3 integrantes da comunidade destacando nestas dimensões da agroecologia, do cuidado e do comunitário. A base teórica principal articula a realidade da comunidade em questão (TORINELLI, 2016), o plano de ordenamento territorial participativo em território agrário (PDA, 2001), GUTIERREZ E SALAZAR (2015, 2017), e OROZCO (2014). Como resultados o cotidiano narrado evidenciou o protagonismo das mulheres camponesas como mobilizadoras dos trabalhos de cuidados e trabalhos comunitários. Estes foram e são geradores de renda, possibilitaram a permanência na terra, potencializaram a transição agroecológica no assentamento e também consolidaram a estruturação e manutenção da Sede Comunitária. Esses processos foram referenciais importantes no contexto das investigações das pesquisas sobre planejamentos contra hegemônicos e em territórios interioranos, contribuindo em campos exploratórios de um planejamento territorial comunitário que considere o tempo e a centralidade do cuidado da reprodução da vida.Palavras chave: mulheres camponesas, agroecologia, cuidado, planejamento territorial comunitário e reprodução da vida.
Impact of the transient groundwater with seismic load on the nailed slope stability
Authors: Mahdi Hasan Hadi 
Published: November 2024

AbstractAn analysis study was conducted to evaluate the effect of the transient groundwater table with and without impacts of seismic loads on stability of excavation nailed slope using Bishop and Janbu simplified methods. The results showed that the factor of safety values increased with increasing of the groundwater table depth and reached a relatively maximum level for each of the two methods of analysis when the groundwater table drops to the depths 18, 19, and 20 m. Also, the results indicated that the percentage of increase in the factor of safety decreased significantly, starting from depth = 13 m, and the differences converge greatly to the point of fading at depths 17 and 18 m and these findings support the notion that the presence of groundwater table in the upper layers of the excavation sides poses a greater risk and increases the possibility of collapse failure.
Processing of sedimentation curves in determining particle size distribution
Authors: Kryuchkov Yu. N. 
Published: November 2024

Processing of sedimentation curves in determining particle size distributionThe method of determining the particle size distribution based on experimental sedimentation data has been clarified. The technique allows us to obtain a particle distribution corresponding to their respective size, both by mass and by the number of particles in the fractions of the material. It is shown that the distributions have the opposite character. A comparative calculation with known methods has been carried out. Ill. 2. Ref. 14. Tab. 1.
A 10-year retrospective study on primary and recurrent hidradenitis suppurativa
Authors: Alla Mrinalini , Kiarie Patrick , Bodden Chloe , Aponte Daphne Gonzalez , Janbey Selma , Louis Martine A. , Miele Andrew , Mandava Nageshwara 
Published: November 2024

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterized by follicular occlusion and apocrine gland inflammation. It is often misdiagnosis and delays, resulting in poor quality of life in some cases and severe consequences and poor patient outcomes. Limited literature compares presentation and treatment outcomes of recurrent HS, any information may aid clinicians in prompt diagnosis and treatment to alleviate the various challenges patients face and the complications from disease progression.
Methods: A 10-year (2012-2022) retrospective chart review of the Epic Medisys database that analyzed patients admitted to flushing hospital center with a diagnosis of HS as a primary or secondary diagnosis at our community teaching hospital in Flushing, New York.
Results: In our patient sample, HS was most commonly diagnosed in African-American and female patients under the age of 30 years. Common comorbidities included obesity. Antibiotics had the highest cure rate overall, and surgical interventions were more effective for recurrent disease.
Conclusions: From our study we concluded that most patients were African American and female presenting younger than 30 years with axillary lesions most commonly characterized as nodules and abscesses. Antibiotics had the highest cure rate for both groups; with surgical intervention more effective from recurrent disease.
A comparative study between early and conventional intestinal stoma closure in a tertiary care institute
Authors: Vatvani Vijay , Khoja Hanuman Ram , Krishna Chappidi Vamsi , Rustagi Saaransh , Jain Richa 
Published: November 2024

Background: Little is known about ideal time for stoma closure. Therefore, the aim of this study is to compare early versus conventional stoma closure following bowel surgery in terms of quality of life (QoL), length of hospital stay (LoH), and postoperative complications.
Methods: This randomized controlled trial was conducted at a medical college affiliated teaching hospital from May 2023 to June 2024. The 116 patients undergoing bowel surgery with temporary stoma creation were randomized into early closure (3 weeks post-surgery) and conventional closure (8-12 weeks post-surgery) groups. Primary outcome was anastomotic leak rate. Secondary outcomes included other postoperative complications, LoH, and QoL assessed using the EORTC QLQ-C30 questionnaire.
Results: There was no significant difference in anastomotic leak rates between early (6.9%) and conventional (12.1%) closure groups. Overall complication rates were similar (56.9% early vs 50% conventional). LoH did not differ significantly between groups. QoL scores were significantly higher in the early closure group, with 100% of patients achieving considerable improvement (EORTC score 26-36) compared to 79.3% in the conventional group (p<0.05).
Conclusions: Early stoma closure is safe and feasible in appropriately selected patients, with no increased risk of anastomotic leak or other complications. It significantly improves QoL compared to conventional closure timing, without prolonging hospital stay. These findings suggest that early stoma closure may be a beneficial option for suitable patients following bowel surgery.
A year of public laparoscopic sleeve gastrectomy
Authors: Gabsi Kheira , Siow Yian Y. , Hariswamy Soumya , Garcia Naydeli , Zarrouk Ali 
Published: November 2024

Bariatric surgery is becoming increasingly prominent in Australia, however over 90% is still performed in the private sector. We examined the outcomes of the first year of our publicly funded bariatric surgery program, which includes regular review in a metabolic clinic by an Endocrinologist and Allied Health. The characteristics and outcomes of 22 consecutive patients who underwent publicly funded Laparoscopic Sleeve Gastrectomy with a single surgeon at a South-West Sydney public hospital between March 2023 and May 2024 were retrospectively collected. Data on patient characteristics, operative details and post-operative outcomes was collected and analysed. The majority of patients were women (77%), with a mean age of 48±10.6. Mean initial weight at program commencement was 136.7±25.7 kg, and mean BMI 49±6 kg/m2. All patients had >2 obesity related comorbidities; 45% were diabetic. There were no complications or re-admissions. At 6 months post-op, mean weight loss from baseline weight was 34.3±17 kg, with mean TBWL 24.8% ± 9.6% and EBWL 52%±17.7%. For patients with 12 month follow up data, mean weight loss was 46.6 kg±27.9, with mean TBWL of 33%±14% and EBWL of 68 %±23%. Our first year of public Laparoscopic Sleeve Gastrectomy, in conjunction with a comprehensive metabolic program, has been shown to be safe and effective, with preliminary data demonstrating outcomes equivalent to those previously published.
Skipanarligar fortreytir og føroysk stjórnarviðurskifti
Authors: West Hallbera 
Published: November 2024

Political Parties are complex organisations with different tasks and roles. It is clear that political parties solve important tasks in the Faroese democratic system. This article focuses on the political parties, the party system, and Faroese governments. The article builds on the assumption that institutional settings influence the conditions for government activity. The article identifies factors for the Faroese system like a multi-party system with a weak political centre and coalition governments with larger policy stretch compared to other political systems, which means potential challenges. The investigation, however, shows that despite these identified factors, the political system has a continuous structure and also governments are rather stable at the same time as parties take turns in government coalition formation.
Observation of switchable polar skyrmion bubbles down to the atomic layers in van der Waals ferroelectric CuInP2S6
Authors: Xue Fei , Zhang Chenhui , Zheng Sizheng , Tong Peiran , Wang Baoyu , Peng Yong , Wang Zhongyi , Xu Haoran , He Youshui , Zhou Hongzhi , Wang Nan , Han Peng , Yuan Youyou , Ma Yinchang , Huan Chu , Zhang Senfu , Chen Hongliang , Zhu Haiming , Xu Yang , Yu Bin , Sun Jian , Wang Hua , Chen Peng , Gao Xingsen , Chang Kai , Tian He , Wang Jie , Zhang Xixiang 
Published: November 2024

Abstract

Polar skyrmions are topologically nontrivial polarization textures that demonstrate exotic physical phenomena and novel memory applications1-9. Thus far, these textures have primarily been reported in oxide-ferroelectric-based epitaxial heterostructures because their stabilization requires an elastic energy penalty from the epitaxial strains3-8. Here, without the epitaxial-strain engineering, we discover polar skyrmion bubbles in stand-alone van der Waals ferroelectric CuInP2S6 crystal through the combination of piezoelectric force microscopy, high-resolution transmission electron microscopy, and phase-field simulations. In a thick CuInP2S6 flake of over ~100 nm, skyrmion bubbles feature an elliptical hedgehog-like state with center-divergent or center-convergent configurations. Progressively thinning the flake thickness to ~8 nm allows a topological transition from elliptical to circular skyrmionic patterns. Interestingly, the skyrmions can be switched with the change in helicity by probe-applied electrical and mechanical stimuli, which is distinct from the creation and annihilation of other reported skyrmions. Both theoretical and experimental data proves that the formation and thickness-dependence of skyrmion textures primarily stem from charge-related energy penalty. This work opens up a new material system (i.e., two-dimensional layered ferroionic materials) for exploring uncharted polar-topology physics and prospective neuromorphic devices.
Welding of Additively Manufactured Aluminium Alloy Components: Challenges and Mitigation Strategies
Authors: Nunes Rafael , Faes Koen , Verlinde Wim , Probst Florian , De Freese Jens , Arnhold Julius , De Waele Wim , Lezaack Matthieu , Simar Aude 
Published: November 2024

Abstract

Additive manufacturing (AM) has contributed to significant advances in the production of aluminium alloys, particularly through powder bed fusion (PBF) and directed energy deposition (DED) processes. However, joining of conventionally and additively manufactured components remains essential. This work focuses on the weldability of AM aluminium alloys using fusion and solid-state welding processes. The study analyses the microstructural evolution and mechanical properties, revealing a relationship between AM technology and joining process. In particular, fusion welding of PBF-LB produced aluminium alloys presented a significant limitation due to the high porosity level, especially in the weld zone near the PBF-LB base material. This region of high porosity, known as the pore belt region, has an enormous detrimental effect on the mechanical properties of the weld. This phenomenon is not observed when the welds are carried out by solid-state welding processes, which makes this group of welding processes very suitable for this type of material. On the other hand, fusion welding of aluminium alloys produced by Wire Arc Additive Manufacturing (DED-Arc or WAAM) exhibits a good stability and repeatability, analogous to conventional aluminium alloy welding practices. Rotational friction welding of DED-Arc-produced components presented an unexpected challenge. Due to the difference in ductility compared to conventionally manufactured parts, the process window for optimal process pressure was found to be very narrow and sensitive. The findings are confirmed by metallographic examination, hardness profile measurement, tensile and bend testing.