bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nursing Students, Faculty, and Preceptors Perception of Effective Characteristics of Clinical Instructor: A Cross-Sectional Study
Authors: Buanz Shmayil F. , Alsenayien Abrar Y. , Altharman Hanin A. , Alnaqi Rawan I. , Llaguno Maria Blesilda B. , Mousa Ola , Siraj Rayan A. 
Published: November 2024

Background Nursing instructors play an important role in improving the clinical experience of nursing students. Despite this, little is known about the characteristics of effective clinical instructors. Objective Identifying the perceptions of nursing students, faculty, and preceptors of effective clinical instructors. Method A descriptive cross-sectional study was conducted using a convenience sample of nursing students, faculty, and preceptors from different nursing departments. Participants were invited to respond to sociodemographic and Nursing Clinical Teacher Effectiveness Inventory questionnaires from April 2022 to September 2022. The data were analyzed using descriptive and inferential statistics using SPSS. Result A total of 715 participants responded to the survey, of whom 510 were students. Students valued interpersonal relations (5.57 ± 1.261) as the most important clinical instructor characteristic, while nursing competence was perceived as the least important (5.51 ± 1.298). Faculty scored the highest mean in the evaluation subscale (6.21 ± 1.170) and the lowest in nursing competence (6.07 ± 1.221). Preceptors scored the highest mean in the evaluation subscale (5.98 ± 0.904) and the lowest in personality (5.80 ± 0.928). One-way ANOVA showed significant mean differences between the perceptions of nursing students, faculty, and preceptors in personality ( M: 5.54 vs. 6.10 vs. 5.80, respectively; p < .001), evaluation ( M: 5.56 vs. 6.21 vs. 5.98; p < .001), teaching ability ( M: 5.57 vs. 6.12 vs. 5.86; p < .001), nursing competence ( M: 5.51 vs. 6.12 vs. 5.86; p < .001), and interpersonal relationship ( M: 5.57 vs. 6.17 vs. 5.88; p < .001). There were significant mean differences in students’ perceptions across academic levels. Conclusion Students, faculty, and preceptors perceived effective clinical instructors’ characteristics differently. Therefore, nursing schools should establish and promote a program to develop and promote unified, effective clinical teaching characteristics.
A Survey Study on the Factors Affecting Breastfeeding Self-Efficacy Among Postpartum Women in Mother–Infant Separation Wards
Authors: Si Cheng Cheng , Mao Aimei 
Published: November 2024

Background Self-efficacy serves as a crucial predictor for successful breastfeeding. The standard practice in maternal wards is mother–baby rooming-in, which is believed to enhance breastfeeding rates post-delivery. However, in certain maternal wards, mother–baby separation continues to occur due to diverse factors. Objectives The objective of this study is to examine the self-efficacy levels of mothers in mother–infant separation wards and identify the factors that influence their self-efficacy. Methods A cross-sectional study was undertaken in 2022 at a hospital in Macau, involving 290 postpartum women in mother–infant separation wards. A self-designed questionnaire encompassing demographic details and breastfeeding information was utilized. Additionally, the Chinese version of the Breastfeeding Self-Efficacy Scale (BSES) and the Social Support Scale (SSRS) were employed. SPSS26.0 software was used to analyze the data. p < .05 indicated statistically significant differences. Results The average breastfeeding self-efficacy score among the women was 96.03 ± 23.07, which accounted for 64% of the total score. The factors influencing breastfeeding self-efficacy were ranked based on their impact power as follows: previous experience of breastfeeding, intended length of breastfeeding, employment status, and the number of breastfeeding sessions during hospitalization after childbirth ( p < .05). These four factors collectively explained 34.7% (R2 = 0.347) of the variations in breastfeeding self-efficacy scores. A weak but positive correlation was observed between postpartum women's breastfeeding self-efficacy and social support for the mothers ( r = .341, p < .001). Conclusion The breastfeeding self-efficacy scores of postpartum women were found to be at a moderate level. Mother–infant separation during the postpartum period has an impact on breastfeeding self-efficacy, but the impact can be managed. When developing programs to enhance postpartum mothers’ breastfeeding self-efficacy, it is important to consider their individual and social circumstances, as well as the advantages and disadvantages associated with mother–infant separation during the postpartum period.
Factors Effective in Lowering Professional Commitment in Nursing and Strategies to Address Them: A Scoping Review
Authors: Nabi Foodani Mahdi , Abbasi Dolatabadi Zahra , Goudarzian Amir Hossein , Mosazadeh Hasan , Poortaghi Sarieh 
Published: November 2024

Objectives This study explores the factors leading to decreased professional commitment among nurses and proposes actionable solutions to mitigate the challenges posed by this phenomenon in nursing. Methods This research was conducted by employing the scoping review methodology. To this end, the relevant studies were obtained by two researchers independently searching over Scopus, Medline (via PubMed), Proquest, SID, Magiran, and Web of Science databases. The extracted data from the primary studies were organized into a table, including author names, publication year, study population, study objectives, study methodology, and key findings. Results Based on the primary research question, seven main themes contributing to the decline in professional commitment to nursing were determined as follows: professional and organizational challenges, human relations, personal wellbeing and coping, work–life balance and success, organizational culture, the nature of the nursing profession and beliefs, human emotions, values, and ethics. Also, the secondary question of the research was responded to by identifying four main themes: (1) empowering nurses, (2) nursing leadership and support, (3) safety concerns and interactions with patients, and (4) welfare facilities. Conclusion The findings of this study highlight the necessity of implementing nurse empowerment programs and providing financial and moral support from the organization and nursing leaders to enhance professional commitment to nursing.
Keller and Interphalangeal Joint Resection Arthroplasties for Chronic Noncomplicated Diabetic Ulcers of the Hallux: A Systematic Review and Meta-analysis
Authors: Yammine Kaissar , Mouawad Joseph , Honeine Mohammad Omar , Assi Chahine 
Published: November 2024

Background: Surgery is often needed for resistant plantar diabetic foot ulcers (DFUs) of the big toe. For noninfected ulcers, 2 types of surgery are available: the Keller and the hallux interphalangeal joint arthroplasty (HIPJ-A) procedures. Yet, no evidence synthesis on the outcomes of these procedures has been conducted; thus, this systematic review is an attempt to fill this gap. Methods: Only studies reporting the results of Keller (or its variants) and HIPJ-A (or its variants) procedures for noncomplicated ulcers (Texas 1A/2A, or Wagner I/II) were included. Ulcers located beneath the metatarsal head were excluded. Ultimately, 11 studies were selected for inclusion and were analyzed. The primary outcome was defined as the ulcer healing frequency. The secondary outcomes were mean healing time, ulcer recurrence frequency, ulcer transfer frequency, postoperative infection rate, and revision surgery rate. Results: The overall (combined techniques) weighted healing rate was 94% with a mean healing time of 3.1 ± 0.4 weeks. The ulcer recurrence frequency was 6%, the ulcer transfer frequency 4.5%, the postoperative infection rate 18%, and the revision surgery rate 3.8%. No significant differences were found between both techniques. When compared to standard of care, the odds ratio of ulcer healing frequency was 27.1 (95% CI 1.442-508.174, P = .01) in favor of the Keller arthroplasty with a faster healing time ( P = .02). Conclusion: Both surgical offloading procedures are highly effective in treating chronic noncomplicated DFU of the plantar aspect of the hallux along with low complication frequencies. There is a need to fine-tune the indication in relation to the location of the plantar wound with future comparative controlled research studies with far more patients than we could include in this meta-analysis.
Criteria for Identifying Candidates for Systemic Psoriasis Treatment in the Real World: Application of the International Psoriasis Council Guidelines in Patients in North America
Authors: Strober Bruce , Zhong Yichen , Sima Adam , Beeghly Alicia , Eckmann Thomas , Balagula Eugene , Zhuo Joe , Lebwohl Mark 
Published: November 2024

Background The International Psoriasis Council (IPC) updated the classification of psoriasis severity to guide clinical decision-making. According to IPC guidelines, patients are considered candidates for systemic therapy when body surface area (BSA) is >10%, when lesions affect special body areas (ie, face, palms, soles, genitals, scalp, or nails), or when topical therapy fails to control symptoms. Objective To evaluate patient candidacy for systemic therapy in real-world settings, according to disease severity criteria. Methods This cross-sectional study included systemic treatment-naive patients from the CorEvitas Psoriasis Registry who initiated systemic treatment at Registry visits between April 2015 and April 2023. Based on IPC criteria, systemic therapy candidates were identified, and data on demographics and clinical characteristics, including disease severity indicators (ie, BSA and Psoriasis Area Severity Index [PASI] scores) and patient-reported outcome measures, were collected and descriptively summarized. Results The analysis included 2739 systemic therapy initiators with plaque psoriasis, of whom 82.7% met IPC criteria for systemic therapy. Of the 2265 systemic therapy candidates, 56.2% had a BSA >10%, 53.2% had a history of psoriasis affecting special areas, and 55.2% had prior but not current use of topical therapy. Notably, 71.0% of candidates for systemic therapy had PASI scores ≤12. Conclusion In this large real-world study, most patients with psoriasis who initiated systemic therapy met the IPC disease severity criteria to do so. Disease severity categorization based on PASI scores and BSA percentage alone may not adequately capture all patients who might be candidates for systemic psoriasis treatment. Clinicaltrials.gov NCT02707341.
A Case of Tubercular Pleural Effusion in a Child Following Erythema Nodosum
Authors: Verma Shalini , Kapoor Sakshi , Srivastava Geetika 
Published: November 2024

Erythema nodosum (EN), a form of septal panniculitis, is rare in pediatric age group. It can be primary/idiopathic as well as secondary due to various conditions such as tuberculosis, streptococcal infections, autoimmune disorders, drugs, and inflammatory bowel diseases. The association of EN with latent tuberculosis has been widely reported in the adult population but literature is scarce on the association of EN with tuberculosis in the pediatric age group. Here we present a case of a child who presented with pleural effusion of tubercular origin with a recent history of EN. The patient was also evaluated for the other causes of EN and responded well to the antitubercular treatment.
Beyond static measurements: dynamic frailty improves survival prediction in multiple myeloma
Authors: Smits Febe , Groen Kaz , Levin Mark-David , Stege Claudia A. M. , van Kampen Roel , van der Spek Ellen , Bilgin Yavuz M. , Thielen Noortje , Nijhof Inger , Ludwig Inge , de Waal Esther G. M. , Sandberg Yorick , Kentos Alain , Timmers Gert-Jan , Regelink Josien C. , Westerman Matthijs , de Heer Koen , Vekemans Marie-Christiane , Durdu-Rayman Nazik , de Graauw Nicole C. H. P. , Seefat Maarten R. , van de Donk Niels W. C. J. , Ypma Paula F. , Nasserinejad Kazem , Zweegman Sonja 
Published: November 2024

Abstract
The level of frailty, according to the International Myeloma Working Group frailty index, is highly dynamic during antimyeloma treatment. Dynamic frailty assessment improved the prediction of survival and early mortality compared with the prognostic value of static frailty level at baseline.
TRPV4 activation by core body temperature has multimodal functions in the central nervous system
Authors: Shibasaki Koji 
Published: November 2024

AbstractBrain temperature is strictly regulated by various endogenous mechanisms and significantly contributes to brain function in homeothermic animals, making it an important factor for health. Thermosensitive transient receptor potential (TRP) channels convert temperature information into electrical signals through cation influx. In particular, TRPV4 is involved in the regulation of brain function. TRPV4, constitutively active in neurons through its activation by brain temperature, increases neuronal firing. TRPV4KO mice have electroencephalogram abnormalities, resulting in depression-like and social behavioral abnormalities. This basic function of TRPV4, as a translator of brain temperature information, has been implicated in several diseases, including epilepsy and stress-induced depression. In addition to its neuronal functions, TRPV4 has many key functions in glia and vasculature that depend on brain temperature and contribute to brain activity. In this review, I summarize the importance of TRPV4 activities in relation to brain temperature and focus on how hyperthermia-induced TRPV4 dysfunction exacerbates brain diseases.
Mitochondrial dysfunction and impaired DNA damage repair through PICT1 dysregulation in alveolar type II cells in emphysema
Authors: Simborio Hannah , Hayek Hassan , Kosmider Beata , Elrod John W. , Bolla Sudhir , Marchetti Nathaniel , Criner Gerard J. , Bahmed Karim 
Published: November 2024

Abstract
Background
Alveolar type II (ATII) cells have a stem cell potential in the adult lung and repair the epithelium after injury induced by harmful factors. Their damage contributes to emphysema development, characterized by alveolar wall destruction. Cigarette smoke is the main risk factor for this disease development.

Methods
ATII cells were obtained from control non-smoker and smoker organ donors and emphysema patients. Isolated cells were used to study the role of PICT1 in this disease. Also, a cigarette smoke-induced murine model of emphysema was applied to define its function in disease progression further.

Results
Decreased PICT1 expression was observed in human and murine ATII cells in emphysema. PICT1 was immunoprecipitated, followed by mass spectrometry analysis. We identified MRE11, which is involved in DNA damage repair, as its novel interactor. PICT1 and MRE11 protein levels were decreased in ATII cells in this disease. Moreover, cells with PICT1 deletion were exposed to cigarette smoke extract. This treatment induced cellular and mitochondrial ROS, cell cycle arrest, nuclear and mitochondrial DNA damage, decreased mitochondrial respiration, and impaired DNA damage repair.

Conclusions
This study indicates that PICT1 dysfunction can negatively affect genome stability and mitochondrial activity in ATII cells, contributing to emphysema development. Targeting PICT1 can lead to novel therapeutic approaches for this disease.
The immune regulatory role of lymphangiogenesis in kidney disease
Authors: Lu Xiangheng , Ma Kuai , Ren Junyi , Peng Haoyu , Wang Jia , Wang Xiaoxiao , Nasser Moussa Ide , Liu Chi 
Published: November 2024

AbstractThe renal lymphatic system is critical for maintaining kidney homeostasis and regulating the immune response inside the kidney. In various kidney pathological situations, the renal lymphatic network experiences lymphangiogenesis, which is defined as the creation of new lymphatic vessels. Kidney lymphangiogenesis controls immunological response inside the kidney by controlling lymphatic flow, immune cell trafficking, and immune cell regulation. Ongoing study reveals lymphangiogenesis’s different architecture and functions in numerous tissues and organs. New research suggests that lymphangiogenesis in kidney disorders may regulate the renal immune response in various ways. The flexibility of lymphatic endothelial cells (LECs) improves the kidney’s immunological regulatory function of lymphangiogenesis. Furthermore, current research has shown disparate findings regarding its impact on distinct renal diseases, resulting in contradictory outcomes even within the same kidney condition. The fundamental causes of the various effects of lymphangiogenesis on renal disorders remain unknown. In this thorough review, we explore the dual impacts of renal lymphangiogenesis on several kidney pathologies, with a particular emphasis on existing empirical data and new developments in understanding its immunological regulatory function in kidney disease. An improved understanding of the immunological regulatory function of lymphangiogenesis in kidney diseases might help design novel medicines targeting lymphatics to treat kidney pathologies.
Association between the heaviness of smoking index (HSI) and quit attempts and quit intentions among cigarette smokers in eight African countries
Authors: Jena Pratap Kumar , Okoye Pamela Chekwube , Patel Arpita , Satpathy Nancy , Kamsa-ard Supot , Mohapatra Debasish , Mangoti Shilpa , Nyirenda Esther , Desta Getahun Bahiru , Justin Elikana Kulwa 
Published: November 2024

Abstract
Introduction
The increasing smoking population in Africa necessitates intensified tobacco cessation services. Assessing nicotine dependence with tools such as the heaviness of smoking index (HSI) aids in cessation efforts. This study evaluated the association between HSI and quit attempts and quit intentions among African cigarette smokers.

Methods
Global Adult Tobacco Survey (GATS) data from eight African countries collected between 2011 and 2018 were analysed. The time to first smoke (TTFS) and number of cigarettes per day (CPD) were used to estimate the HSI score and dependence level. The association between HSI dependence level and quit attempts and quit intentions was evaluated using likelihood ratios (LR).

Results
Among 2,399 daily cigarette users, 1,618 (67.5%) were exclusive cigarette users. The average and median CPDs were 8.27 ± 8.3 and 5 (IQR: 2–18), respectively, with Ethiopia having the highest mean CPD (11.6). In Ethiopia, 51.5% of exclusive and 42% of nonexclusive users had low dependence (HSI < 2), whereas 43.9% and 31.3% of other African countries had low dependence. The association between low dependence and quit attempts was significant only for exclusive cigarette smokers in Ethiopia, with LR of 1.45 (95% CI: 1.08–1.93). The association between low dependence and quit intentions was significant in Ethiopia for both exclusive (LR = 1.42) and nonexclusive (LR = 1.53) users. None of the LR estimates were > 10 or < 0.1.

Conclusion
The association between low dependence (HSI < 2) and quit behaviour was limited in African settings, highlighting the complex interplay between usage patterns, dependence assessment, and quit behaviour. A contextual tool for assessing nicotine dependence tailored to African settings is warranted for effective smoking cessation.
Pneumonitis after normofractionated radioimmunotherapy: a method for dosimetric evaluation
Authors: Kraus Kim Melanie , Bauer Caroline , Steinhelfer Lisa , Feuerecker Benedikt , Martins Juliana Cristina , Fischer Julius Clemens , Borm Kai Joachim , Peeken Jan Caspar , Bernhardt Denise , Combs Stephanie Elisabeth 
Published: November 2024

Abstract
Background
Post-Therapy-Pneumonitis (PTP) is a critical side effect of both, thoracic radio(chemo)therapy (R(C)T) and immune checkpoint inhibition (ICI). However, disease characteristics and patient-specific risk factors of PTP after combined R(C)T + ICI are less understood. Given that RT-triggered PTP is strongly dependent on the volume and dose of RT [1], driven by inflammatory mechanisms, we hypothesize that combination therapy of R(C)T with ICI influences the dose-volume-effect correlation for PTP. This study focuses on the development of a method for evaluation of alterations of dosimetric parameters for PTP after R(C)T with and without ICI.

Methods and materials
PTP volumes were delineated on the follow-up diagnostic Computed Tomography (CT) and deformably matched to the planning CT for patients with PTP after thoracic R(C)T + ICI or R(C)T. Dose data was converted to 2-Gy equivalent doses (EQD2) and dosimetrically analyzed. Dosimetric and volumetric parameters of the segmented PTP volumes were analyzed. The method was exemplarily tested on an internal patient cohort including 90 patients having received thoracic R(C)T + ICI (39) and R(C)T (51). Thirtytwo patients with PTP were identified for further analysis. Additional data on previous chemotherapy, RT, smoking status and pulmonary co-morbidity were conducted. A matched pair analysis with regard to planning target volumes (PTV) was conducted for curative intended (definitive) and palliative patient cohorts individually.

Results
The presented method was able to quantify and compare the dosimetric parameters of PTP for the different therapies. For our study group, no significant differences between R(C)T + ICI and R(C)T only was observed. However, the dosimetric analysis revealed large volumetric fractions (55%) of the PTP volumes to be located outside of high dose (EQD2 < 40 Gy) regions for R(C)T + ICI. There was a non-significant trend towards increased area under the curve of the dose volume histogram (AUC) values for R(C)T + ICI compared to R(C)T only (3743.6 Gy∙% vs. 2848.8 Gy∙%; p-value = 0.171). In contrast to the data for the palliative intended treatment group, for definitive R(C)T + ICI, data tended towards increased volumes with higher doses.

Conclusions
The proposed method was capable to quantify dosimetric differences in the dose-volume-effect relationship of PTP for patients with R(C)T + ICI and patients with R(C)T only. In this exploratory analysis, no significant dosimetric differences within PTP volumes for the different groups could be observed. However, our observations suggest, that for safe application of thoracic R(C)T + ICI, further careful investigation of dosimetric prescription and analysis concepts with larger and conformer study groups is recommendable.