bluuebunny/crossref_metadata_2025_split huggingface dataset:
LOW-DENSITY LIPOPROTEIN SUBFRACTIONS AND VARYING DEGREE OF CORONARY STENOSIS
Authors: Ozerova I. N. , Perova N. V. , Metelskaya V. A. , Chernushevich O. I. , Gavrilova N. E. 
Published: August 2018

Aim.To investigate whether low and intermediate density lipoprotein (LDL, IDL) subfractions are associated with a degree of angiographically verified coronary atherosclerosis, as well as with other biochemical risk factors of coronary heart disease (CHD), and hypertriglyceridemia (HTG) in particular.Material and methods.The study included 129 patients (76 men and 53 women), aged 33–75 years, who were referred for coronary angiography. All participants were divided into three groups by the degree of coronary artery (CA) stenosis: 0–20%, 21–70%, and >70%. LDL and IDL subfractions were measured with the Lipoprint LDL System (electrophoresis in 3% polyacrylamide gel).Results.All groups were similar by the levels of lipid and apoprotein parameters. The levels of high-sensitive C-reactive protein and glucose, as well as HOMA-IR index, were higher in Group 3 patients. In most cases of severe CA stenosis, small dense LDL particles were detected. In HTG patients, higher levels of small dense LDL3 particles were registered only together with the CA stenosis of at least 21–70%.Conclusion.The findings on lipoprotein subfractions, obtained with the Lipoprint LDL System, have demonstrated that in patients with verified coronary atherosclerosis, there is a link between the levels of more atherogenic small dense LDL3 particles, the degree of CA stenosis, and blood TG levels. The combination of HTG and high LDL3 levels could be considered an additional marker of severe CA atherosclerosis.
ROLE OF GENETIC FACTORS IN THE DEVELOPMENT OF CLOPIDOGREL RESISTANCE AMONG PATIENTS REFERRED FOR PERCUTANEOUS CORONARY INTERVENTIONS
Authors: Matskeplishvili S. T. , Prokhorchuk E. B. , Arutyunova Ya. E. , Koksheneva I. V. , Shakhnazaryan L. S. , Sandukhadze B. R. , Skryabin K. G. , Melerzanov A. V. , Buziashvili Yu. I. 
Published: August 2018

Aim. To study the associations between genetic polymorphisms and the development of clopidogrel resistance in patients referred for percutaneous coronary interventions (PCI).Material and methods. The study included 84 patients with coronary heart disease (CHD), who underwent planned PCI. Dynamic assessment of platelet aggregation was performed using light transmission aggregometry method (two-channel laser analyser Biola-230LA). The role in the development of inadequate suppression of platelet aggregation during the standard-dose dual antiplatelet therapy (DAT) was investigated for the following genes and polymorphic alleles: CYP2C19 (rs4244285*2, rs4986893*3, rs28399504*, rs56337013*5, and rs12248560*17); CYP2C9 (rs1057910*3); CYP3A4 (rs2242480); CYP2B6 (rs3211371 (5*); CYP3A5 (rs28365083*2 and rs776746); and CYP1A2 (rs762551).Results. The two study groups demonstrated a statistically significant difference in the prevalence of CYP2C19 rs4244285 (2*) polymorphisms, with an increase in GA and AA genotypes and a reduction in the “wild” GG genotype (Χ2 =11,7; р=0,003). The GA genotype was associated with inadequate suppression of platelet aggregation in patients receiving clopidogrel (75 mg/d) and aspirin (300 mg/d; odds ratio 6,27; 95% confidence interval 1,8–21,69). No significant inter-group differences were observed for other polymorphisms (CYP2C9 (rs1057910*3); CYP3A4 (rs2242480); CYP2B6 (rs3211371 (5*)); CYP3A5 (rs28365083*2, rs776746); and CYP1A2 (rs762551)).Conclusion. The degree of platelet aggregation in patients on DAT is related to their genetic status. The assessment of genetic polymorphisms can facilitate the choice of optimal therapeutic strategies in clopidogrel-resistant patients. Patients with the CYP2C192* polymorphism are in particular need for an additional correction of the antiaggregant treatment scheme.
RISK OF RECURRENT THROMBOTIC EVENTS IN PATIENTS WITH ACUTE CORONARY SYNDROME AND HIGH PLASMA LEVELS OF D-DIMER
Authors: Panina A. V. , Puchinyan N. F. , Dovgalevskyi Ya. P. , Furman N. V. , Dolotovskaya P. V. , Malinova L. I. 
Published: August 2018

Aim. To study the association of plasma D-dimer levels and the risk of thrombotic events in patients hospitalised with acute coronary syndrome (ACS).Material and methods. The study included 70 patients, aged 34-88 years, who were admitted to the Acute Coronary Care Unit with the ACS diagnosis.Results. During the follow-up period, thrombotic events were registered in 12 patients (17%). Three patients with myocardial infarction (MI) suffered recurrent MI. Nine patients were rehospitalised with the unstable angina (UA) diagnosis. All participants were divided into quartiles by the levels of D-dimer (25% percentile 136 ng/ml; median 1250 ng/ml; and 75% percentile 2930 ng/ml). High plasma levels of D-dimer (third quartile) were associated with a 1,5-fold increase in the risk of recurrent thrombotic events among ACS patients.Conclusion. In ACS patients, plasma D-dimer levels could be regarded as one of the additional risk factors of thrombotic events.
ASSESSMENT OF MYOCARDIAL REPERFUSION QUALITY IN PATIENTS WITH ACUTE CORONARY SYNDROME AND ST SEGMENT ELEVATION, BASED ON THE CRITERIA BY THE AMERICAN COLLEGE OF CARDIOLOGY/AMERICAN HEART ASSOCIATION
Authors: Posnenkova O. M. , Kiselev A. R. , Gridnev V. I. , Popova Yu. V. , Dovgalevskyi P. Ya. , Oshchepkova E. V. 
Published: August 2018

Aim. To use the criteria by the American College of Cardiology/American Heart Association (ACC/AHA), in order to assess the quality of myocar-dial reperfusion in Russian patients with acute coronary syndrome (ACS) and ST segment elevation (STE-ACS).Material and methods. We analysed the clinical data of 25682 patients with STE-ACS, who were treated (2010–2011) in Russian hospitals participating in the Russian ACS Registry. The following ACC/AHA indicators (2008) were used: “time to thrombolysis” — the percentage of STE-ACS patients who received thrombolysis within 30 minutes after admission; “time to primary percutaneous coronary intervention (PCI)” — the per-centage of STE-ACS patients in whom primary PCI started within 90 minutes after admission; and “reperfusion” — the percentage of STE-ACS patients who underwent any reperfusion intervention within 12 hours after the chest pain onset.Results. Among 25682 STE-ACS patients, any reperfusion intervention (PCI and/or thrombolysis, in any order) were performed in 12043 (46,9%). Among 7437 STE-ACS patients who underwent thrombolysis, 5119 (69%) met the inclusion criteria. In this group, the indicator “time to thrombolysis” was met in 3342 patients (65,3%). Among 5405 STEACS patients who underwent PCI, 3993 (73,9%) met the inclusion criteria. In these patients, the indicator “time to primary PCI” was met in 2797 (70%). Finally, among 25135 (97,9%) patients with STE-ACS who were included in the analyses, the indicator “reperfusion” was met in 9800 (38,9%).Conclusion. The main problem of the health care for Russian patients with STE-ACS is the limited reperfusion coverage. However, the reperfusion quality could be regarded as satisfactory.
IMPLEMENTATION OF EVIDENCE-BASED CLINICAL-AND-MORPHOLOGICAL APPROPRIATE USE CRITERIA FOR CORONARY REVASCULARIZATION IN PATIENTS WITH ACUTE CORONARY SYNDROME IN RUSSIA
Authors: Popova Yu. V. , Posnenkova O. M. , Kiselev A. R. , Gridnev V. I. , Dovgalevsky P. Ya. 
Published: August 2018

Aim. To study possibility of using the evidence-based clinical-andmorphological appropriate use criteria for percutaneous coronary interventions (PCIs) for expert evaluation of high-technology procedures implementation in patients with acute coronary syndrome (ACS) in Russia.Materials and methods. The appropriateness of performed PCI was assessed in patients with ACS, underwent coronary revascularization. The potential need in PCI was determined in ACS patients refused from coronary revascularization. Assessment was performed with the help of ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 Appropriate Use Criteria for Coronary Revascularization Focused Update (ACCF 2012). Data from 65,912 ACS patients, containing in Russian ACS Registry (2010–2011) were examined.Results. ACCF 2012 criteria allow to assess the clinical appropriateness of PCI in 79.2% of patients underwent coronary revascularization and to determine the potential need in PCI in 80.6% of patients, refrained from coronary revascularization. Among ACS patients underwent PCI (n=9147), intervention was appropriate in 68.9% of cases. Inappropriate PCI was revealed in 4.6% of cases. Among patients refrained from PCI (n=56765), coronary revascularization was potentially appropriate in 57.9% of cases.Conclusion. ACCF 2012 clinical-and-morphological criteria allow to judge on appropriateness of performed PCI and to evaluate the potential need in PCI among the most part of Russian ACS patients. In present study coronary revascularization was appropriate in the majority of ACS patients. It was shown possible to use the evidence-based clinical-andmorphological criteria for expert evaluation of high-technology procedures implementation in Russian ACS patients.
THE EFFECTIVENESS OF CARVEDILOL AND EPROSARTAN IN PATIENTS WITH METABOLIC SYNDROME AND CHRONIC HEART FAILURE
Authors: Dashnamirov R. L. 
Published: August 2018

Аim. of the study was to assess the effectiveness of carvedilol and eprosartan in addition to the traditional treatment (Nitrosorbid 30mg/day + Digoxin 0.25mg/day + TromboASS 100mg/day + Atorvastatin 20mg/day + Furosemid 40mg/day + Verospiron 50mg/day + Atenolol 12.5–25 mg/day) in patients with metabolic syndrome and chronic heart failure.Materials and methods. 91 patients with MS and CHF included sharing mentioned criteria. Carvedilol in doses of 6,25 ÷ 25 mg/day and eprosartan in doses of 300 ÷ 600 mg/day were administered in addition to the traditional treatment.Results. After 12 months of treatment systolic BP decreased by 23.6% and diastolic by 17.2%. Heart rate decreased by 23.1%, and exercise tolerance increased by 22.3%. Dynamics of the presented indicators are statistically significant.Conclusion. Administration of an alpha-beta blocker carvedilol and angiotensin II receptor blocker eprosartan in the above dosages promote the longest remission of heart failure, improvement in functional class and regression of pathological remodeling.
Перспективные расчеты населения в Германии
Authors: Пётч Ольга 
Published: August 2018

Целенаправленная социально-экономическая политика немыслима без представлений о будущем развитии населения и его структуры. Перспективные расчеты населения позволяют получить такого рода компас. Их результаты показывают, как будут изменяться численность и структура населения при определенных гипотезах о развитии рождаемости, смертности и миграции. Поскольку эти демографические процессы протекают очень постепенно и их воздействие проявляется в полной мере лишь через несколько десятилетий, особый интерес представляют расчеты на долгосрочную перспективу.
Данная статья знакомит с официальными перспективными расчетами населения Федерального статистического управления Германии. Опираясь на широко распространенные в международной практике когортно-компонентный метод и сценарную технику, они имеют ряд особенностей. Как трактовка целей и интерпретация результатов, так и некоторые детали методологии, и дизайн сценариев как системы равноценных вариантов будущего развития отличны от принятых в настоящее время в России. На примере предположений 13-го координированного перспективного расчета о будущей динамике рождаемости статья знакомит с одним из возможных подходов к моделированию гипотез. В основе этого подхода находится анализ тенденций динамики репродуктивного поведения женщин реальных поколений. В заключение сделанные на базе данных 2013 г. выводы о будущем уровне итоговой рождаемости критически анализируются с учетом новых данных до 2016 г. о подъеме деторождения в Германии. Анализ факторов, сопутствующих этому процессу, позволяет оценить их потенциал для будущего развития рождаемости.
A study of role of non-operative management in blunt abdominal trauma with solid organ injury
Authors: Bansod Atish N. , Umalkar Rohan , Shyamkuwar Ambrish T. , Singade Amar , Tayade Priyanka , Awachar Neha 
Published: August 2018

Background: The present study of role of non-operative management in blunt abdominal trauma with solid organ injury was done to assess the feasibility and safety of non-operative management in hemodynamically stable patients and identify the causes, predictive factors to delineate the rate of non-operative management failure.Methods: A longitudinal observational study was carried out from September 2013 to November 2015. All cases of blunt trauma abdomen with ultrasonological e/o solid organ injury and were hemodynamically stable were included in study.Results: Total 138 cases presented with a history of blunt trauma abdomen of which 56 cases had ultrasonological evidence of solid organ injury. 8 cases were excluded as 6 of these were hemodynamically unstable at presentation while 1 had bowel perforation and another had severe head injury all requiring operative management. Maximum cases were of age group 21-30 years (41.66%) and 31-40 years (31.25%). 42 (87.5%) cases were male and 6 (12.5%) cases of 48 were females. 28 (66.67%) cases presented as Road Traffic Accident. 28 (66.67%) cases had abdominal pain as the commonest symptom while tenderness in 38 (79.17%) cases and tachycardia in 30 (75%) cases was the predominant sign. Most injuries were seen in spleen 23 (47.92%) cases f/b Liver with 14 (29.12%). Conservative management was successful in 40 (83.33%) cases and failed in 8 (16.67%) cases. Mortality of the study was 1 (2.08%) case.Conclusions: Non-operative strategy is a successful approach in patients who are hemodynamically stable and authors strongly recommend it.
Clinical profile and outcome of pelvi-ureteric junction obstruction (PUJO) in children presenting above 1 year
Authors: S. Pramod , Ramji Ashwath Narayan 
Published: August 2018

Background: Pelvi-ureteric junction obstruction (PUJO) is defined as anatomical or functional obstruction to the flow of urine from the pelvis to the upper ureter. With the advent of ultrasonography most of the cases of PUJO are identified in antenatal period. The treatment protocol for antenatal diagnosed PUJO is standardized. Few children present later in life. Present study was done to evaluate clinical profile and outcome of children presenting with PUJO above 1 year.Methods: A retrospective observational study conducted by the department of Paediatric Surgery, KIMS hospital Bangalore. All children with PUJO above 1 year of age from January 2015 to January 2018 were included. Clinical, biochemical and imaging findings of these children were tabulated. A diuretic renogram was done to confirm the diagnosis. The children underwent either pyeloplasty or nephrectomy, depending on the function of the kidney. In children with calculi, pyelolithotomy with pyeloplasty was done. The children were followed up post-surgery.Results: Twenty-six children were included in the study. Mean age of presentation was 6.86±4.13years. Most common presentation was pain abdomen. Left kidney was commonly involved. The mean anteroposterior pelvic dimension (APPD) of involved kidney was 38.96±17.7 mm. 5 children presented with poorly functioning kidney with split renal function less than 10%. In three children PUJO was associated with pelvic calculi. Out of the 26 children simple nephrectomy was required in 4 (15%) children. The remaining 22 children underwent pyeloplasty. Mean duration of stay was 6.19±1.8 days. Post-pyeloplasty diuretic renogram showed improved drainage with improved function.Conclusions: PUJO is common cause of urinary obstruction in children. Delay in diagnosis or presentation leads to increased chances of renal damage and loss. Hence it is important to diagnose PUJ obstruction at the earliest and receive prompt treatment.
Early periventricular leukomalacia in preterm neonates
Authors: Kapoor Saurabh , Sharma Ravi , Sapare Anilkumar , Aggarwal Rajiv 
Published: August 2018

Background: Preterm neonates are at increased risk for brain injury. More than 10% will sustain neurological injuries leading to significant learning disabilities, motor developmental delay, cerebral palsy, seizures and mental retardation. Periventricular leukomalacia (PVL) is the most common form of white matter injury of prematurity. The objective of the present study was to identify the incidence of early periventricular leukomalacia (PVL) and its associated risk factors in the study group.Methods: All preterm neonates with either Gestational age <32weeks and/or Birth weight <1500 grams who were admitted to Neonatal Intensive Care Unit within the period of 1st November 2013 to 30th April 2015 were taken for study. A total of 112 babies met the inclusion criteria but 104 were finally taken into the study. Screening of intraventricular haemorrhage and early PVL changes in VLBW babies was done by neurosonogram on day 3 and day 14 of life by a single well qualified radiologist. Follow up cranial ultrasound was done weekly for the babies who were diagnosed to have IVH and/or PVL by day 14 of life.Results: The incidence of early periventricular leukomalacia in very low birth weight babies in present study was 7.7%. It was seen that 87.5% babies had periventricular flares and 12.5% babies had cystic changes. It was seen that birth weight<1000grams (OR 0.006; CI:0.00-0.50; p value 0.023) and neonatal sepsis (OR 80.9; CI:1.65-3947.6;p value 0.027) significantly increased the risk of developing PVL in VLBW babies. The duration of hospital stay was found to be significantly increased in babies having PVL.Conclusions: The incidence of early periventricular leukomalacia in babies born <32weeks gestation and/or birth weight<1500grams is 7.7%. Birth weight <1000 grams and neonatal sepsis were found to increase the risk of periventricular leukomalacia in these babies.
A study on the failure of breast feeding during the first month of life with effect on immunological level
Authors: Datta Shyamali , Datta Bijan Kumar , Banik Avirupa Kansha , Datta Nilanjan 
Published: August 2018

Background: In the critical phase of immunological immaturity of the newborn, particularly for the immune system of mucous membranes, infants receive large amounts of bioactive components through colostrum and breast milk. Breastfeeding provides unsurpassed natural nutrition to the newborn and infant. Study was done to know the effects of breast milk feeding versus formula feeding in early infancy on the development of serum IgA, IgM and IgG.Methods: The present study investigated 100 cases of failure of breast feeding. The cases included both complete and partial failure. Values of immunoglobulin levels (IgA, IgM and IgG) in the serum of eleven breast fed and eleven artificially fed infants (all aged one month) were determined using Tripartigen plates.Results: Mean level of IgA in artificially fed infants was 20.72±3.82µg/100 ml. The diameter of precipitin ring using sample number 7 was 3.9 mm. The mean level of IgA in breast fed infants was 25.94±3.89 µg/100 ml. The mean level of IgM in artificially fed infants was 31.690±3.504 µg/100 ml. The mean level of IgM in breast fed infants was 36.81±5.13 µg/100 ml. The mean level of IgG in artificially fed infants was 480.25±52.23 µg /100 ml. The mean level of IgG in breast fed infants was 517.59±56.72 µg /100 ml.Conclusions: It is evident from the results of immunoglobulin estimation (Ig A, Ig M and IgG) in infants with artificial milk and in infants with breast milk (vide table 5, 6, 7, 8, 9 and 10) that though the mean serum levels (Ig A, Ig M and IgG) in breast fed infants were slightly higher than that of artificially fed infants. There was no statistically significant difference in the serum immunoglobulin levels between these two groups.
Grafting to denuded nasal cavity for prevention of recurrent nasal polyposis by endoscopic sinus surgery
Authors: Amin Hany , Mandour Yasser Mohammed Hassan , Elrefai Ahmed 
Published: August 2018

<p class="abstract"><strong>Background:</strong> The objective of the study was to avoid nasal polyposis occurrence after recurrent FEES.</p><p class="abstract"><strong>Methods:</strong> 87 patients undergoing recurrent FESS due to recurrent nasal polyposis, after completing all steps of FESS the placement of normal nasal mucosa from inferior turbinate or nasal septum instead of the mucosa of the fovea ethmoidalis and lamina papyracea was done. </p><p class="abstract"><strong>Results:</strong> There were nasal obstruction improvement in 79 patients (90.8%), but there were 8 patients (9.2%) had recurrent nasal polypi causing nasal obstruction. There was smell improvement in 38 patients (71.7%) out of 15 patients (28.3%).</p><p class="abstract"><strong>Conclusions:</strong> The nasal cavity grafting in FESS of recurrent nasal polyposis with nasal septal or inferior turbinate mucosa had promising results in prevention of nasal polyposis recurrence. These results made a recommendation of nasal cavity grafting during primary FESS of nasal polyposis.</p>
Squamous cell carcinoma of maxillary sinus: a comparison of clinico-radiological staging with pre-operative staging
Authors: Sudheer C. P. , Singh T. Dinesh 
Published: August 2018

<p class="abstract"><strong>Background:</strong> The nasal cavity and paranasal sinuses are the site of origin of more complex, histologically diverse group of tumors which include neoplasms derived from mucosal epithelium, seromucinous glands and haematolymphoid cells. This study aimed to assess the incidence and prognosis of maxillary sinus malignancy.</p><p class="abstract"><strong>Methods:</strong> A total 25 (16 males, 09 females) malignancy cases between age group 11-70 years. All the cases were undergone with detailed clinical examination. The TNM staging system was followed to detect and standardize the disease stage. CT scan was used to identify the growth and extent of tumor. </p><p class="abstract"><strong>Results:</strong> Majority cases were between the age group 41-50 years (40%). Epistaxis was the commonest clinical symptom in 72% cases followed by nasal obstruction (68%), oral related symptoms (56%), oedema in cheeks (44%) and auditory disturbances in 16% cases. The TNM Staging system showed that 76% cases had T3 lesions, 16% had T4 lesions and 8% had T2 lesions. Nasal symptoms are commonly associated with malignancies and were belongs to T3 stage and few under T4.</p><p class="abstract"><strong>Conclusions:</strong> Maxillary si­nus malignancy is an aggressive tumor normally diagnosed at the advanced stage, with minimal prognosis and reduced survival rate. Surgery in combination with radiotherapy followed by chemotherapy remains the best treatment modality.</p>