bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of clinical, radiographic and surgical outcomes of total hip arthroplasty between direct anterior and posterior approaches: a systematic review and meta-analysis
Authors: Jia Fangteng , Guo Bin , Xu Feixiang , Hou Yuechao , Tang Xiongfeng , Huang Lanfeng 
Published: December 2018

Objective: A systematic review and meta-analysis were used to directly evaluate the direct anterior approach (DAA) and the posterior approach (PA) for early efficacy and safety of total hip arthroplasty (THA). Methods: Control-led trials assessing DAA and PA for the efficacy and safety of THA were searched in the database. Articles were reviewed according to predetermined inclusion and exclusion criteria; the quality of the methodology included in a given study was strictly assessed before data extraction. Moreover, meta-analysis was performed for outcomes that can be combined; otherwise, descriptive analysis was performed. Results: There were 20 articles included, with a total of 7377 patients. Among these, 3728 and 3649 cases were in the DAA and PA groups, respectively. There was no difference between the DAA and PA groups at postoperative week 2 in the number of patients using the assistive ambulatory device or in time needed to completely discontinue all assistive ambulatory devices. Descriptive analysis found that DAA was slightly better than PA regarding early functional recovery and activity after surgery, as well as postoperative pain relief. Hospitalisation stay in the DAA group was shorter than in the PA group, in which the patients had a shorter operative time. Radiographic outcomes showed that there was little difference in prosthetic position between the DAA and PA groups. The proportions of intraoperative fractures and postoperative lateral cutaneous nerve of the thigh (LCNT) neuropraxia were significantly higher in the DAA group than in patients who underwent PA. Conclusion: Compared with PA, DAA presents superior early recovery following THA.
Insertion of peripherally inserted central catheters with intracavitary electrocardiogram guidance: A randomized multicenter study in China
Authors: Yin Yu-Xia , Gao Wei , Li Xu-Ying , Lu Wei , Deng Qian-Hong , Zhao Cui-Yun , Liu Xue-Rong , Zhou Chao , Hou Wen-Bo , Lu Shou-Tao , Liu Guang , Wang Lu-Ning , Li Mao-Quan , Zhang Hai-Jun 
Published: December 2018

Introduction: Ultrasound-guided venipuncture and tip location by intracavitary electrocardiogram have many advantages during the insertion of peripherally inserted central catheters, both in terms of safety and cost-effectiveness. Recently, a new tip-conductive peripherally inserted central catheters and new Doppler ultrasound device integrated with intracavitary electrocardiogram have been introduced into clinical practice in China. A randomized multicenter study (clinical trial no. NCT03230357) was performed to verify the feasibility and accuracy of intracavitary electrocardiogram, as performed with this new peripherally inserted central catheters and device. Methods: Our study enrolled a total of 2250 adult patients in 10 different Chinese hospitals. The patients were randomly assigned to either the study group (intracavitary electrocardiogram) or the control group (anatomical landmark guidance) in a 2:1 allocation. Ultrasound was used in both groups for venipuncture and tip navigation. All patients underwent chest X-ray after the procedure to verify the position of the catheter tip. Results: No insertion-related complications were reported in either group. In the study group, first-attempt successful tip location was 91.7% (95% confidence interval: 90.3%–93.1%), significantly higher than 78.9% (95% confidence interval: 76.0%–81.9%) observed in the control group (p < 0.001). As evaluated by post-procedural chest X-ray, tip location in the study group had a sensitivity of 99.3% (95% confidence interval: 98.8%–99.7%), significantly higher than 86.8% (95% confidence interval: 84.4%–89.2%) observed in the anatomical landmark group (p < 0.001). Conclusion: These results indicated that during peripherally inserted central catheters insertion in adult patients, tip location with intracavitary electrocardiogram guidance, as carried out by a new tip-conductive peripherally inserted central catheters and intracavitary electrocardiogram integrated ultrasound device, was more effective and more accurate than tip location using anatomical landmarks.
The Dosimetric and Temporal Effects of Respiratory-Gated, High-Dose-Rate Radiation Therapy in Patients With Lung Cancer
Authors: Rouabhi Ouided , Gross Brandie , Bayouth John , Xia Junyi 
Published: December 2018

Purpose: To evaluate the dosimetric and temporal effects of high-dose-rate respiratory-gated radiation therapy in patients with lung cancer. Methods: Treatment plans from 5 patients with lung cancer (3 nongated and 2 gated at 80EX-80IN) were retrospectively evaluated. Prescription dose for these patients varied from 8 to 18 Gy/fraction with 3 to 5 treatment fractions. Using the same treatment planning criteria, 4 new treatment plans, corresponding to 4 gating windows (20EX-20IN, 40EX-40IN, 60EX-60IN, and 80EX-80IN), were generated for each patient. Mean tumor dose, mean lung dose, and lung V20 were used to assess the dosimetric effects. A MATLAB algorithm was developed to compute treatment time. Results: Mean lung dose and lung V20 were on average reduced between −16.1% to −6.0% and −20.0% to −7.2%, respectively, for gated plans when compared to the corresponding nongated plans, and between −5.8% to −4.2% and −7.0% to −5.4%, respectively, for plans with smaller gating windows when compared to the corresponding plans gated at 80EX-80IN. Treatment delivery times of gated plans using high-dose rate were reduced on average between −19.7% (−0.10 min/100 MU) and −27.2% (−0.13 min/100 MU) for original nongated plans and −15.6% (−0.15 min/100 MU) and −20.3% (−0.19 min/100 MU) for original 80EX-80IN-gated plans. Conclusion: Respiratory-gated radiation therapy in patients with lung cancer can reduce lung dose while maintaining tumor dose. Because treatment delivery during gated therapy is discontinuous, total treatment time may be prolonged. However, this increase in treatment time can be offset by increasing the dose delivery rate. Estimation of treatment time may be helpful in selecting patients for respiratory gating and choosing appropriate gating windows.
Evolution of Dementia Related to the Use of Alcohol in the French Nationwide Discharge Summary Database Between 2007 and 2017
Authors: Rochoy Michaël , Gautier Sophie , Béné Johana , Bordet Régis , Chazard Emmanuel 
Published: December 2018

Background: The French nationwide exhaustive hospital discharge database (PMSI) is used for activity-based payment of hospital services. We hypothesized that the release of articles about alcohol and dementia could influence the identification of these diagnoses in PMSI. Methods: We analyzed temporal evolution of coding for dementia and other persistent or late-onset cognitive impairment (OPLOCI) due to alcohol and other psychoactive substances in the PMSI database from 2007 to 2017 (285 748 938 inpatient stays). These codings use the International Classification of Diseases, 10th revision (ICD-10). Results: The number of inpatient stays with dementia and OPLOCI due to alcohol increased from 34 to 1704 from 2007 to 2017. While the number of diagnosed dementias remained stable at around 400 from 2013, the number of OPLOCIs increased 10-fold from 2013 to 2017. This increase was not found with dementia or OPLOCI due to other psychoactive substances than alcohol. Conclusion: Notoriety of a diagnosis in the literature seems to have an impact on the coding.
Systematic review of facilitated communication 2014–2018 finds no new evidence that messages delivered using facilitated communication are authored by the person with disability
Authors: Hemsley Bronwyn , Bryant Lucy , Schlosser Ralf W , Shane Howard C , Lang Russell , Paul Diane , Banajee Meher , Ireland Marie 
Published: December 2018

Background and aims Facilitated Communication (FC) is a technique that involves a person with a disability pointing to letters, pictures, or objects on a keyboard or on a communication board, typically with physical support from a “facilitator”. Proponents claim that FC reveals previously undetected literacy and communication skills in people with communication disability. However, systematic reviews conducted up to 2014 reveal no evidence that the messages generated using FC are authored by the person with a disability. This study aimed to conduct a systematic review of the literature on FC published between 2014 and 2018 to inform the 2018 update of the 1995 American Speech-Language-Hearing Association Position Statement on FC. Method A systematic search was undertaken to locate articles about FC in English published in the peer reviewed literature since 2014; and to classify these according to the study design for analysis. Studies meeting the inclusion criteria were classified according to four categories of evidence: (a) quantitative experimental data pertaining to authorship, (b) quantitative descriptive data on messages produced using FC, (c) qualitative data, or (d) commentary material on FC. Main contribution In total, 18 studies met the inclusion criteria. There were no new empirical studies and no new descriptive quantitative studies addressing the authorship of messages delivered using FC. Three new qualitative studies qualified for inclusion; these did not first establish authorship. Of the 15 new commentary papers on FC located, 14 were critical and one was non-critical. The results could be used to inform the development or update of current position statements on FC held locally, nationally, and globally. Conclusion There are no new studies on authorship and there remains no evidence that FC is a valid form of communication for individuals with severe communication disabilities. There continue to be no studies available demonstrating that individuals with communication disabilities are the authors of the messages generated using FC. Furthermore, there is substantial peer-reviewed literature that is critical of FC and warns against its use. Implications FC continues to be contested in high profile court cases and its use promoted in school settings and workshops at university campuses in the US. Our empty systematic review will influence both clinical practice and future clinical guidance; most immediately the American Speech-Language-Hearing Association Position Statement on FC and any future guidance issued by the 19 associations worldwide with positions against FC.
The 3rd Antibody Validation meeting: Bath UK 20-21st September 2018
Authors: Goodman Simon L. 
Published: December 2018

The International Antibody Validation meetings offer a welcome British forum for discussing this important topic, which is existentially crucial for the biological sciences community. Now in its 6th year, the biennial meeting is organized by Andrew Chalmers (University of Bath; CiteAb), this year with Carly Dix (Astra Zeneca). The organizers gathered some 100 members of industry and academia, producers and users, for a day and a half to describe their efforts to ensure that their antibodies have the desired specificity and selectively for well-defined molecular targets. The meeting is largely available as WebCasts (http://www.antibodyvalidation.co.uk/past-events/2018).
30 años de la revista Historia Contemporánea
Authors: Esteban de Vega Mariano 
Published: December 2018

La revista Historia Contemporánea fue creada en 1988, dentro del departamento de Historia Contemporánea de la Universidad del País Vasco, por iniciativa de Manuel Tuñón de Lara, uno de los principales referentes de la historiografía española al final del franquismo. Desde entonces, ha sido una de las revistas españolas de historia más prestigiosas y, en los últimos años, también una de las que han alcanzado un mayor impacto editorial.Este artículo realiza una historia de los treinta años de esta publicación e identifica sus fases principales. Su evolución se inserta además en los cambios experimentados por la historiografía española de su tiempo, de la que ha sido uno de sus principales referentes. Tanto sus contenidos como su configuración actual resultan significativos de la progresiva asimilación por el medio académico español de las pautas seguidas a escala internacional por las publicaciones científicas.Palabras Clave: Historia de la historiografía; historiografía española; revistas de historia; Manuel Tuñón de Lara
Il tempio dei divi Traiano e Plotina, l’arco partico e l’ingresso settentrionale al foro di Traiano: un riesame critico delle scoperte archeologiche
Authors: La Rocca Eugenio 
Published: December 2018

Riassunto: Del templum divi Traiani abbiamo sicure attestazioni dalle fonti le quali, tuttavia, non chiariscono quale fosse la morfologia dell’edificio né quale fosse la sua effettiva ubicazione, che sappiamo, comunque, connessa con la colonna di Traiano. I recenti scavi eseguiti nelle fondazioni del palazzo Valentini non hanno risolto il problema. La riproposizione di un edificio templare di ordine gigantesco, con 8 × 10 (o 9) colonne di granito egiziano di 50 piedi di altezza, continua a basarsi sulla ricostruzione ipotetica dell’area a settentrione del foro di Traiano codificata da Guglielmo Gatti (sulla base di appunti del nonno Giuseppe) e da Italo Gismondi. In realtà, le indagini finora compiute non lo consentono. Inoltre, le soluzioni finora proposte non tengono conto dell’arco partico di Traiano, la cui collocazione all’ingresso meridionale del foro di Traiano, come suggerito da Rodolfo Lanciani e da Italo Gismondi, non può più essere sostenuta. È verosimile che l’arco, i cui lavori, avviati nel maggio del 116 d.C. erano ancora in corso al momento della morte di Traiano, il 7 agosto del 117 d.C., fosse invece all’ingresso principale del foro, il settentrionale, in un’area interessata da interventi edilizi di Adriano, di cui ci sfuggono, purtroppo, l’entità e le motivazioni. La presenza obbligatoria dell’arco partico nella zona parzialmente occupata dal templum divi Traiani, almeno secondo le più recenti proposte di ricostruzione, costringe a rivedere su basi differenti l’assetto adrianeo dell’area del foro di Traiano a nord della colonna coclide.Parole chiave: Traiano, topografia romana, architettura romana.
El racismo discursivo en la prensa escrita: una mirada teórica desde el Análisis Crítico del Discurso y la Sociología de los medios.
Authors: Sáez Gallardo Julio Renato 
Published: December 2018

Esta aproximación teórica pretende como objetivo central comprender cómo las rutinas profesionales de los periodistas y de los medios de comunicación condicionan la contrucción noticiosa acerca de las minorías étnicas. Para ello, emplearemos el Análisis Crítico del Discurso y la Sociología de los medios y sus correspondientes categorías analíticas como constructos epistemológicos y metodológicos y las vincularemos a investigaciones teórico-empíricas para validar la hipótesis de este trabajo: la praxis racista de la cultura periodística deviene de condicionamientos propios del quehacer de las organizaciones mediáticas, lo que produce un discurso discriminador referente a las minorias étnicas ( migrantes y pueblos originarios).
Pautas de redacción y análisis de contenido en noticias sobre suicidio en la prensa española e internacional: efecto Werther&Papageno y seguimiento de las recomendaciones de la OMS
Authors: Lois-Barcia Melani , Rodríguez-Arias Icía , Túñez Miguel 
Published: December 2018

En España fallecen por suicidio el triple de personas que en accidente de tráfico, pero la muerte intencional sigue siendo un asunto que en las redacciones informativas se silencia por considerar que su visibilidad fomenta el aumento de conductas imitativas. La Organización Mundial de la Salud promueve desde 2000 una guideline para el abordaje informativo del suicidio en la que se proponen comportamientos diferentes: informar con responsabilidad y de modo que se colabore en dinámicas de prevención. Esta investigación revisa libros de estilo o códigos de conducta de FAPE, de los nueve colegios profesionales de España y de 23 organizaciones profesionales internacionales y analiza las noticias online durante seis meses en una muestra intencional de 11 periódicos de referencia (El País, El Mundo, La Vanguardia, La Voz de Galicia y El Periódico, The Guardian, Le Monde, The New York Times, The Washington Post, Corrieri della Sera y Público) para identificar si existen pautas que orienten el abordaje informativo e intentar determinar si la política informativa apuesta por fomentar el efecto Werther (silencio) o el efecto Papageno (prevención).PALABRAS CLAVE: Medios de comunicación, responsabilidad social,prensa, suicidio.
ISOLASI SENYAWA ANTIOKSIDAN DALAM EKSTRAK HEKSANA KULIT BATANG MANGGIS HUTAN (Garcinia bancana Miq.)
Authors: Hartati Sri , Masrukhan Masrukhan , Cahyana Herry 
Published: December 2018

Antioksidan adalah suatu senyawa yang dapat menangkap radikal bebas. Salah satu sumber anti oksidan alami adalah dari tumbuh-tumbuhan. Dalam usaha pencarian antioksidan baru, telah dilakukan identifikasi senyawa antioksidan dari ekstrak n-heksana kulit batang Garcinia bancana Miq dengan metode 1,1-difenil-2-pikrilhidrazil (DPPH). Metode isolasi dilakukan dengan cara kombinasi kromatografi (Kromatografi kolom vacum, kromatografi kolom gravitasi, kromatografi lapis tipis sentrifugal dan kromatografi lempeng tipis) Penentuan struktur molekul berdasarkan analisis data spektroskopi UV-VIS, IR, LC-MS, NMR proton dan karbon. Dari hasil isolasi didapatkan suatu senyawa isoprenil bezofenon dengan bobot molekul 466,22 dan rumus molekul C28H34O6 dengan nama IUPAC 3-(3,4-dihidroksibenzoil)-4-hidroksi-8-8-dimetil-1,7-bis(3-metilbut-2enil) bisiklo (3.3.1) non-3-ene-2,9-dione atau disebut bacanone yang diduga senyawa baru. Dari proses isolasi juga ditemukan senyawa atsiri b- caryophyllene, α-humulene dan b-cadinene serta stigmasterol. Hasil uji aktivitas antioksidan ekstrak n-heksana dan hasil isolat murni menunjukkan IC50 berturut-turut 17,78 ppm dan 12,79 ppm dimana pembanding kuersetin adalah 9,90 ppm.Kata kunci: Garcinia bancana, antioksidan, DPPH, 3-(3,4-dihidroksibenzoil)-4-hidroksi-8-8-dimetil-1,7-bis(3-metilbut-2enil)bisiklo(3.3.1)no-3-ene-2,9-dione, bacanone. Antioxidants are compounds that can capture free radicals. One source of natural antioxidant is from plants. On searching for new antioxidant, identification of antioxidant compound of the n-hexane extract of the stem bark of Garciniabancana Miq was done by 1.1-diphenyl-2-pikrilhidrazil (DPPH) method. Isolation active compound were done by combination of chromatographic methods (Flash column chromatography, gravitation column chromatography, cetrifugal thin layer chromatography and thin layer chromatography) .Determination of molecular structure by analysis spectroscopic data of UV-VIS, IR, LC-MS, NMR proton and carbon.Isolation results were isophrenyl bezophenon with molecular weight 466.22 and the molecular formula is C28H34O6 IUPAC name 3 - (3,4-dihydroxybenzoil)-4-hydroxy-8-8-dimethyl-1,7-bis (3-methylbut-2enyl) bicyclo (3.3.1) non-3-ene-2,9-dione or named bacanone wich is suspected as a new compound. From the isolation were also found of known volatile compounds b - caryophyllene, α-humulene and b-cadinene and stigmasterol. The test results of antioxidant activity of n-hexane extract and pure compound showed IC50 respectively 17.78 ppm and 12.79 ppm which comparison with quercetin is 9.90 ppm. Key words : Garcinia bancana Miq., antioxidant, DPPH, 3-(3,4-dihydroxybenzoil)-4-hidroxy-8-8-dimethyl-1,7-bis (3-methylbut-2enil)bisiklo(3.3.1)no-3-ene-2,9-dione, bacanone.
SINTESIS, UJI AKTIVITAS SITOTOKSIK IN VITRO DAN MOLECULAR DOCKING SENYAWA 1-(4-KLOROBENZOIL)-1,3-DIMETILUREA
Authors: Pangaribowo Dian Agung , Siswandono Siswandono , Purwanto Bambang Tri 
Published: December 2018

Senyawa 1-(4-klorobenzoil)-1,3-dimetilurea telah dirancang, disintesis, diidentifikasi struktur, dan diuji aktivitas sitotoksik secara in vitro. Simulasi docking dilakukan dengan memposisikan senyawa ke dalam sisi aktif reseptor Checkpoint kinase 1 (Chk1) untuk menentukan model pengikatan ligan reseptor. Sintesis 1-(4-klorobenzoil)-1,3-dimetilurea dilakukan lewat reaksi asilasi antara 1,3-dimetilurea dan 4-klorobenzoil klorida. Kemurnian produk hasil sintesis ditentukan dengan metode Kromatografi Lapis Tipis (KLT).Identifikasi struktur dilakukan dengan spektrofotometer UV, FT-IR dan spektrometer NMR. Hasil uji antiproliferatif menunjukkan bahwa senyawa 1-(4-klorobenzoil)-1,3-dimetilurea memiliki aktivitas sitotoksik terhadap sel HeLa yang lebih baik dibandingkan dengan kontrol positif yaitu hidroksiurea. Senyawa 1-(4-klorobenzoil)-1,3-dimetilurea dengan potensi aktivitas sitotoksik ini dapat menjadi agen antikanker yang potensial. Kata kunci: 1-(4-klorobenzoil)-1,3-dimetilurea, molecular docking, sintesis, aktivitas sitotoksik, hidroksiurea A novel 1-(4-chlorobenzoyl)-1,3-dimethylurea has been designed, synthesized, structurally determined, and the in vitro cytotoxic activity was evaluated. Docking simulation was performed to position this compound into the Checkpoint kinase 1 (Chk1) active site to determine the probable binding model. Synthesis of 1-(4-chlorobenzoyl)-1,3-dimethylurea was completed by acylation reaction between 1,3-dimethylurea and 4-chlorobenzoyl chloride. The purity of synthesized product was determined by Thin Layer Chromatography. Structure identification was performed by UV spectrophotometer, FT-IR and NMR spectrometer. Antiproliferative assay result demonstrated that this compound possessed good cytotoxic activity against HeLa cells, which is comparable to the positive control, hydroxyurea. This compound with potent cytotoxic activity might be a potential anticancer agent. Keywords: 1-(4-chlorobenzoyl)-1,3-dimethylurea, molecular docking, synthesis, cytotoxic activity