bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generative Artificial Intelligence: Applications in Scientific Writing and Data Analysis in Wound Healing Research
Authors: Chen Adrian , Qilleri Aleksandra , Foster Timothy , Rao Amit S. , Gopalakrishnan Sandeep , Niezgoda Jeffrey , Oropallo Alisha 
Published: November 2024

ABSTRACT
Generative artificial intelligence (AI) models are a new technological development with vast research use cases among medical subspecialties. These powerful large language models offer a wide range of possibilities in wound care, from personalized patient support to optimized treatment plans and improved scientific writing. They can also assist in efficiently navigating the literature and selecting and summarizing articles, enabling researchers to focus on impactful studies relevant to wound care management and enhancing response quality through prompt-learning iterations. For nonnative English-speaking medical practitioners and authors, generative AI may aid in grammar and vocabulary selection. Although reports have suggested limitations of the conversational agent on medical translation pertaining to the precise interpretation of medical context, when used with verified resources, this language model can breach language barriers and promote practice-changing advancements in global wound care. Further, AI-powered chatbots can enable continuous monitoring of wound healing progress and real-time insights into treatment responses through frequent, readily available remote patient follow-ups.
However, implementing AI in wound care research requires careful consideration of potential limitations, especially in accurately translating complex medical terms and workflows. Ethical considerations are vital to ensure reliable and credible wound care research when using AI technologies. Although ChatGPT shows promise for transforming wound care management, the authors warn against overreliance on the technology. Considering the potential limitations and risks, proper validation and oversight are essential to unlock its true potential while ensuring patient safety and the effectiveness of wound care treatments.
An Early-Stage Economic Evaluation of Superabsorbent Wound Dressings for the Management of Moderately to Highly Exuding Leg Ulcers in Slovakian Settings
Authors: Veličković Vladica M. , Serafin Anna , Arlouskaya Yana , Milde Thurid-Christiane , Halász Beáta Grešš 
Published: November 2024

ABSTRACT

BACKGROUND
The management of chronic leg ulcers, including venous leg ulcers (VLUs), causes a considerable economic and clinical burden to healthcare systems. Factors such as nursing time, hospital care, and wound dressings account for approximately 85% of the total cost. Superabsorbent dressings (eg, superabsorbent polymers [SAPs]) are recommended as a first-line treatment for moderately to highly exuding VLUs.

OBJECTIVE
To assess the cost-effectiveness of utilizing SAPs compared with the standard of care (SoC) for managing patients with moderately to highly exuding VLUs within the Slovakia healthcare settings.

METHODS
The decision-analytic modeling method used a Markov process as microsimulation, with a time horizon of 6 months, from the perspective of the third-party payer in Slovakia. All model inputs were based on data identified through systematic literature reviews.

RESULTS
According to model predictions, the use of SAPs instead of SoC in patients with moderately to highly exuding leg ulcers in Slovakian settings would lead to an improved healing rate of 2.2%, incremental health-related quality of life of 0.143 quality-adjusted life-weeks, and total direct cost savings of €75 (USD $82) per patient over a 6-month period.

CONCLUSIONS
The evaluation’s results align with clinical recommendations that endorse superabsorbent wound dressings as the preferred first-line treatment for moderately to highly exuding VLUs. The findings support the use of these dressings as a cost-saving solution for the National Insurance in Slovakia, when compared with SoC.
Patients’ Willingness to Perform Self-Wound Care: A Cross-sectional Study in the Primary Healthcare Sector in Singapore
Authors: Goh Ling Jia , Zhu Xiaoli 
Published: November 2024

ABSTRACT

BACKGROUND
Patient adherence to performing self-wound care (SWC) has a direct influence on the success of telewound care, a healthcare delivery mode that emerged in 2016 in National Healthcare Group Polyclinics in Singapore to relieve the healthcare burden. This mode of delivery was useful during the pandemic, when nonurgent face-to-face visits were switched to the use of telecommunications for consultation. Telewound care requires that patients be willing to perform wound care on their own; however, whether patients are willing to do so remains unknown.

OBJECTIVE
To identify factors influencing patients’ willingness to undertake SWC using a locally validated tool, the Self-Wound Care Acceptance Survey (SWCAS).

METHODS
The authors recruited 328 participants with wounds from six polyclinics using convenience sampling. Participants rated the 17 items on the SWCAS using a 5-point Likert-type scale, from 1 (strongly disagree) to 5 (strongly agree). Higher scores indicate greater willingness to perform wound self-care.

RESULTS
Only 34.2% of the participants were willing to perform SWC. Patients who had a wound on their back and had transport provided and medical bills paid by family scored lower on the SWCAS. In contrast, patients who had higher education levels, were in the younger age group, were employed, were students, and had medical bills partially or fully paid by their company or insurance scored higher on the SWCAS. Post hoc tests indicated that patients with a wound on the back scored significantly lower on the SWCAS than did patients with wounds in other locations (Ps < .05).

CONCLUSIONS
Additional patient education is needed to increase patients’ acceptance of the SWC concept. Actively promoting SWC by distributing patient education information sheets and pamphlets to eligible patients, addressing negative thoughts or concerns, and encouraging positive thinking and autonomy may encourage patients to accept this concept.
Prevalence, Risk Factors, Causes, Assessments, and Prevention of Medical Adhesive-Related Skin Injury: A Scoping Review
Authors: Du Meichen , Liu Mei 
Published: November 2024

ABSTRACT

OBJECTIVE
To evaluate research on medical adhesive-related skin injury (MARSI), focusing on its incidence, prevalence, risk factors, causes, assessments, and prevention.

DATA SOURCES
Searches were conducted on Wanfang Data, China National Knowledge Infrastructure, PubMed, Web of Science Core Collection, MEDLINE, EMBASE, and the Cumulative Index of Nursing and Allied Health Literature Plus with Full Text.

STUDY SELECTION
Using search terms “medical adhesive related skin injury”, “MARSI”, “adhesive skin injury”, and “medical tape-induced skin injury”, the authors selected 43 original articles published between January 1, 2001, and May 12, 2022, in English or Chinese.

DATA EXTRACTION
Extracted details included the first author; publication year; study location; study type; and specifics on MARSI, such as causes, affected body areas, assessment methods, incidence, prevalence, and prevention.

DATA SYNTHESIS
Medical adhesive-related skin injury frequently occurred on the face and at venipuncture sites. Acrylate-containing adhesives were more likely to cause MARSI. Risk factors include extended hospital stays, lower Braden Scale scores, mechanical ventilation, edema, poor skin condition, and use of certain medications. Incidence or prevalence exceeded 10% across populations, peaking at 60.3% in the pediatric surgical ICU. Mechanical injury had the highest incidence and prevalence among MARSI types. Studied interventions and quality improvement measures were effective in reducing MARSI.

CONCLUSIONS
Despite increasing interest, evidence for reducing MARSI is limited. Future research should focus on distinguishing MARSI types, clarifying incidence and prevalence, assessing risk factors, and implementing screening and quality improvement initiatives.
Irritant Contact Dermatitis Due to Fecal, Urinary, or Dual Incontinence: It Is Time to Focus on Darkly Pigmented Skin
Authors: Bliss Donna Z. , McNichol Laurie , Borchert Kathleen , Garcia Ashlee F. , Jinbo Anne K. , McElveen-Edmonds Keisha , Brathwaite Shakira , Sibbald R. Gary , Ayello Elizabeth A. 
Published: November 2024

ABSTRACT

Irritant contact dermatitis due to fecal, urinary, or dual incontinence (ICD-FIUIDI) is a prevalent problem. Inspection of darkly pigmented skin may miss the signs of inflammation of ICD-FIUIDI, resulting in further skin damage and health disparities. In this article, the authors describe best practices for assessing ICD-FIUIDI in the context of diverse skin types using inspection, interview, health record review, and palpation to develop a plan of care; review ICD-FIUIDI prevention and treatment; and include case examples illustrating the application of these methods. The authors also summarize the epidemiology of ICD-FIUIDI and the basis of skin color and inflammation and discuss issues in practice related to the need to improve assessment of ICD-FIUIDI among patients with darkly pigmented skin. They make recommendations for current practice and future research.

GENERAL PURPOSE
To review best practices related to the assessment of irritant contact dermatitis due to fecal, urinary, or dual incontinence (ICD-FIUIDI) among patients with darkly pigmented skin.

TARGET AUDIENCE
This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and registered nurses with an interest in skin and wound care.

LEARNING OBJECTIVES/OUTCOMES
After participating in this educational activity, the participant will:
1. Identify risk factors for the development of ICD-FIUIDI.
2. Describe clinical features and manifestations of ICD-FIUIDI.
3. Propose recommendations to improve care related to ICD-FIUIDI.
Anterior Column Support With Anterior Lumbar Interbody Fusion Cage Through Posterior Approach Maneuver
Authors: Jo Dae-Jean , Bae Sungsoo , Park Jae-Hyun , Choi Ho Yong 
Published: November 2024

Study Design:
Retrospective cohort study.

Objective:
To evaluate the feasibility of anterior column support through a posterior approach using an anterior lumbar interbody fusion (ALIF) cage.

Summary of background data:
Anterior fusion is an effective way to maintain spinal lordosis; however, it may be technically difficult in some cases.

Methods:
Conventional lumbar fusion and spinal deformity correction surgeries were performed using a conventional ALIF cage with a modified extratransforaminal lumbar interbody fusion (ExTLIF). Patients with 1 or 2 fusion levels were classified into group 1, and those with spinal deformity correction were classified into group 2. Radiologic parameters were evaluated during the follow-up periods.

Results:
A total of 51 patients underwent this procedure. Thirty-five patients (19 male and 16 female, 69.4±9.6 y old) with 37 fusion sites were in group 1, and 16 patients (3 male and 13 female, 71.4±5.7 y old) were in group 2. The mean follow-up periods of groups 1 and 2 were 12.3±3.4 and 10.7±4.7 months, respectively. In group 1, the mean lumbar lordosis and segmental lumbar lordosis increased significantly during the last follow-up (39.9±13.0 and 20.6±6.0 degrees, respectively, both P<0.001), and the mean disc space also increased at the last follow-up (P<0.001). The same was observed in group 2 with significant increases in the mean lumbar lordosis and segmental lumbar lordosis at the last of the follow-up period (46.8±9.3 and 16.9±8.9 degrees, respectively, both P<0.001). The disc space also increased significantly (P<0.001). Fusion rates were 94.2% and 87.5% in groups 1 and 2, respectively, and the corresponding subsidence rates were 85.4% and 68.8%. In group 1, there was a significant correlation between subsidence and cage height (P=0.046).

Conclusion:
This procedure (ExTLIF) can be applied in cases where an anterior approach is contraindicated as well as for deformity correction.

Level of evidence:
Level III.
Oral Myeloid Sarcoma as a Marker of Relapse in Acute Myeloid Leukemia
Authors: Meena Akshay , Rout Newshree , Ganesh Rajesh Nachiappa , Ramassamy Sivaranjini 
Published: November 2024

Abstract:
A 20-year-old woman with acute myeloid leukemia (AML) with monocytic differentiation in remission presented with a recent onset painful indurated swelling on the tongue with fever. Although her peripheral blood picture was normal, the bone marrow biopsy was suggestive of a relapse of AML. A biopsy from the tongue lesion showed diffuse infiltration of lamina propria and submucosa by blast cells, positive for myeloperoxidase and CD11c and suggestive of oral myeloid sarcoma (MS). This presents an uncommon site of occurrence of MS and was a marker of relapse of AML. This case highlights the variable presentation of MS. It should prompt investigation for relapse of hematological malignancy in the bone marrow even in the absence of evidence from peripheral blood.
New Developments and Therapeutic Drug Monitoring Options in Costimulatory Blockade in Solid Organ Transplantation: A Systematic Critical Review
Authors: de Graav Gretchen N. , Udomkarnjananun Suwasin , Baan Carla C. , Reinders Marlies E. J. , Roodnat Joke I. , de Winter Brenda C. M. , Hesselink Dennis A. 
Published: November 2024

Purpose:
In this review, the authors summarized the latest developments in costimulatory blockade to prevent rejection after solid organ transplantation (SOT) and discussed possibilities for future research and the need for therapeutic drug monitoring (TDM) of these agents.

Methods:
Studies about costimulatory blockers in SOT in humans or animal transplant models in the past decade (2014–2024) were systematically reviewed in PubMed, European Union clinical trials (EudraCT), and ClinicalTrials.gov.

Results:
Seventy-five registered clinical trials and 58 published articles were found on costimulation blockade of the CD28-CD80/86, CD40-CD40L, and OX40-OX40L pathways. Belatacept, an antagonist of the CD28-CD80/86 pathway, is the only approved costimulatory agent in SOT, hence accounting for most of the research. Other identified costimulatory blocking agents included abatacept and CD28 antagonists tegoprubart, dazodalibep, and TNX-1500. Although tegoprubart was unsuccessful in pancreas transplantation in nonhuman primates, trials in human kidney transplantation are underway. Dazodalibep trials faced recruitment challenges. TNX-1500 was unsuccessful in animal studies and is currently not pursued in humans. After discontinuation of iscalimab (CD40-CD154 pathway antagonist) in SOT, the alternatives, bleselumab and KPL404, showed promising results in kidney transplantation and cardiac xenotransplantation. Studies on secondary costimulatory pathway antagonists, such as OX40-OX40L, have only used animal models. Despite the low interindividual variability in pharmacokinetics (PK) in all studied agents, TDM could be useful for optimizing dosing in PK/pharmacodynamic (PD) studies.

Conclusions:
The routine use of costimulation blockade in SOT is hindered by problems in efficacy compared with the standard of care. Costimulatory inhibitors could be combined in a calcineurin inhibitor-free regimen. Future PK/pharmacodynamic studies in costimulatory agents and personalized medicine could warrant TDM of these agents.
Surgical Capacity Assessment and Leverage in the Palestinian Land (SCALPEL-I) Study: The First Nationwide Plastic Surgery Capacity Evaluation in Palestine
Authors: Alser Osaid , Ayasa Laith , Alhabil Mohammed , Idais Shahd , Almzayyen Ayah , MohammedAli Majdeddin , Younes Reem , Alghoul Heba , Alser Muath , Stash Bryce , Khundkar Roba , Goodacre Timothy , Gosman Amanda , Pusic Andrea , Bharadia Deepak 
Published: November 2024

Background:
Access to surgical care in low-to-middle-income countries (LMICs), especially in war-torn areas such as the occupied Palestinian territory (oPt), is a global health priority. The plastic surgical capacity in the oPt has not been evaluated. This study provides the first systematic evaluation of plastic surgical capacity in the oPt.

Methods:
A cross-sectional study conducted between December 2022 and February 2023 included facilities providing plastic surgery services in the oPt, except private centers run by nonsurgeons. A modified PIPES (personnel, infrastructure, procedures, equipment, and supplies) tool was used. Data were analyzed for geographic and private/public disparities.

Results:
Eleven facilities were included; 6 (54.5%) were in the West Bank and 5 (45.5%) in Gaza. The majority were private hospitals (n = 6, 54.5%). The mean PIPES score was personnel = 4.3 (4.03), infrastructure = 18.4 (2.4), procedures = 9.8 (3.8), equipment = 19.2 (3.6), and supplies = 22.4 (1.9). Hospital beds, operating rooms, and plastic surgeons per 100,000 people were 33.5, 1.0, and 0.5, respectively. There were 8 board-certified plastic surgeons. No facilities had a plastic surgery residency program. Key deficiencies included: 8 facilities (72.2%) not performing microsurgical free tissue transfers (none in Gaza), 5 (45.5%) lacking a system to identify complications, and 7 (63.3%) not offering regular educational courses. Average power supply was 8.0 hours/day in Gaza and 24.0 hours/day in the West Bank.

Conclusions:
Plastic surgical capacity in the oPt shows significant deficiencies, especially in Gaza. These findings should inform stakeholders to address disparities, develop training programs, and improve access to safe plastic surgery.
Leadership That Leaps Also Runs Deep: Why Purpose Is the Key to Navigating a World of Exponential Change
Authors: Shin Andrew 
Published: November 2024

Back-to-back black swan events during the COVID-19 pandemic and the ensuing economic downturn hastened the rate of change in healthcare. Hospitals and healthcare organizations of all sizes and configurations are facing difficult decisions with greater consequences than ever before—for patients, communities, employees, and the delivery of quality care. It can feel like a leap into the unknown.
It takes a different kind of leader to navigate this exponentially changing healthcare environment—and a different kind of training to ensure that those leaders develop the skills and mental models to advance systemic organizational change.
Healthcare needs transformational leaders who have skills that go beyond subject matter expertise and business sense. We need leaders who emphasize people and purpose and who are willing to take risks to improve sustainability, access to care, and health equity and to build organizations that prioritize mission to the community and support those who choose healthcare as their calling.
Women in Healthcare Leadership: A Personal Path to the C-Suite
Authors: Fontenot Teri G. 
Published: November 2024

Women represent an overwhelming majority of the healthcare workforce, yet they are significantly underrepresented in leadership positions, particularly at the executive and board levels. However, women are uniquely positioned to leverage traits such as compassion, transparency, and the ability to foster teamwork to lead organizations into the next phase of contemporary healthcare delivery. In the future, the pace with which women gain access to the C-suite will accelerate as organizations embrace diversity and select the best-qualified leaders in terms of both experience and leadership style that supports organizational culture.
While the future for women in healthcare leadership looks bright, many women are currently struggling to reach the executive office, facing glass ceilings, competing priorities, and lack of access to support and guidance. In this article, I discuss the role of women in healthcare leadership and offer practical suggestions on how women can reach the top echelon and achieve their goals and aspirations.
Health information technology to advance care in accountable care organizations: Implications for Medicare patients
Authors: Ghosh Kaushik , Al-Amin Mona , Li Kate Jiayi , Muhlestein David 
Published: November 2024

Background
Prior research has explored the link between health information technology (HIT) and performance of accountable care organizations (ACOs). However, the challenges of HIT use in ACOs for the management of chronic diseases among Medicare beneficiaries remain less examined.

Purpose
Given the high costs of implementing HIT and the occurrence of multiple chronic conditions (MCC) among elderly individuals, it is important to understand the extent to which HIT capabilities enable chronic disease management among the Medicare population.

Methodology/Approach
Regression analysis was conducted using data from multiple sources for the year 2017, including Leavitt Partners data, the ACO Public Use File published by the Shared Savings Program of the Centers for Medicare & Medicaid Services (CMS), and the CMS hospital referral region data. The sample consisted of 470 ACOs.

Results
Findings revealed that health information exchange (HIE)- and HIT-enabled patient engagement reduced unplanned admissions for Medicare patients with MCC. When primary care services were utilized, HIE- and HIT-enabled patient engagement and medication reconciliation further decreased unplanned admissions.

Conclusion
This study provides empirical support for HIT’s role in reinforcing the applicability of the chronic care model to improve health outcomes.

Practice Implications
From the managerial perspective, adopting HIT functions that support care management may be important for ACOs to improve patient outcomes.
Waveforms of 4G and 5G Radiofrequency Signals: Are Differences Relevant to Biology or Health?
Authors: Foster Kenneth R. , Maxson David , Zollman Peter M. 
Published: November 2024

Abstract
This Note briefly reviews, at a level that is intended to be accessible to non-specialists, the similarities and differences between waveforms of 4G Long-Term Evolution (4G LTE) and 5G New Radio (5G NR) transmitted by cellular base stations, as a resource for health physicists and others who are engaged in public communication about cellular telephone technologies. Despite the difference in levels of controversy presently existing between 4G LTE (introduced in 2008) and 5G NR (introduced in 2019), the differences in waveform as represented by the baseband waveform are minimal, although 5G NR offers system designers a much wider choice of parameters. Transmitted radiofrequency signals in both technologies appear noise-like, in a frequency range that is narrowly contained in the assigned channel. It is concluded that the modulation differences between 4G LTE and 5G NR are unlikely to have any biological relevance, but the greater range of accessible frequencies in 5G NR suggests the need for further health research, particularly in the 5G FR2 millimeter-wave band.