bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erratum: MIRAB-BALOU, M., HU, Q.L., FENG, J.N. &amp; CHEN, X.X. (2011) A new species of Sericothripinae from China (Thysanoptera: Thripidae), with two new synonyms and one new record. Zootaxa, 3009, 55–61.
Authors: MIRAB-BALOU M. , HU Q. L. , FENG J. N. , CHEN X. X. 
Published: March 2019

One new species of subfamily Sericothripinae (Thysanoptera: Thripidae) is described and illustrated: Hydatothrips longjingensis sp. n., and H. abdominalis (Kurosawa) is newly recorded from China. The following taxonomic changes are established: Sericothrips houji (Chou & Feng) comb. n. (from Hydatothrips).
Predictability of North Atlantic Sea Surface Temperature and Upper-Ocean Heat Content
Authors: Buckley Martha W. , DelSole Tim , Lozier M. Susan , Li Laifang 
Published: March 2019

AbstractUnderstanding the extent to which Atlantic sea surface temperatures (SSTs) are predictable is important due to the strong climate impacts of Atlantic SST on Atlantic hurricanes and temperature and precipitation over adjacent landmasses. However, models differ substantially on the degree of predictability of Atlantic SST and upper-ocean heat content (UOHC). In this work, a lower bound on predictability time scales for SST and UOHC in the North Atlantic is estimated purely from gridded ocean observations using a measure of the decorrelation time scale based on the local autocorrelation. Decorrelation time scales for both wintertime SST and UOHC are longest in the subpolar gyre, with maximum time scales of about 4–6 years. Wintertime SST and UOHC generally have similar decorrelation time scales, except in regions with very deep mixed layers, such as the Labrador Sea, where time scales for UOHC are much larger. Spatial variations in the wintertime climatological mixed layer depth explain 51%–73% (range for three datasets analyzed) of the regional variations in decorrelation time scales for UOHC and 26%–40% (range for three datasets analyzed) of the regional variations in decorrelation time scales for wintertime SST in the extratropical North Atlantic. These results suggest that to leading order decorrelation time scales for UOHC are determined by the thermal memory of the ocean.
Examination of the Predictability of Nocturnal Tornado Events in the Southeastern United States
Authors: Bunker Ryan C. , Cohen Ariel E. , Hart John A. , Gerard Alan E. , Klockow-McClain Kim E. , Nowicki David P. 
Published: March 2019

Abstract
Tornadoes that occur at night pose particularly dangerous societal risks, and these risks are amplified across the southeastern United States. The purpose of this study is to highlight some of the characteristics distinguishing the convective environment accompanying these events. This is accomplished by building upon previous research that assesses the predictive power of meteorological parameters. In particular, this study uses the Statistical Severe Convective Risk Assessment Model (SSCRAM) to determine how well convective parameters explain tornado potential across the Southeast during the months of November–May and during the 0300–1200 UTC (nocturnal) time frame. This study compares conditional tornado probabilities across the Southeast during November–May nocturnal hours to those probabilities for all other November–May environments across the contiguous United States. This study shows that effective bulk shear, effective storm-relative helicity, and effective-layer significant tornado parameter yield the strongest predictability for the November–May nocturnal Southeast regime among investigated parameters. This study demonstrates that November–May southeastern U.S. nocturnal predictability is generally similar to that within other regimes across the contiguous United States. However, selected ranges of multiple parameters are associated with slightly better predictability for the nocturnal Southeast regime. Additionally, this study assesses conditional November–May nocturnal tornado probabilities across a coastal domain embedded within the Southeast. Nocturnal coastal tornado predictability is shown to generally be lower than the other regimes. All of the differences highlight several forecast challenges, which this study analyzes in detail.
Cost‐effectiveness of Screening for Nasopharyngeal Carcinoma among Asian American Men in the United States
Authors: Harris Jeremy P. , Saraswathula Anirudh , Kaplun Brian , Qian Yushen , Chan K. C. Allen , Chan Anthony T. C. , Le Quynh‐Thu , Owens Douglas K. , Goldhaber‐Fiebert Jeremy D. , Pollom Erqi 
Published: March 2019

ObjectiveMost patients with nasopharyngeal carcinoma (NPC) in the United States are diagnosed with stage III‐IV disease. Screening for NPC in endemic areas results in earlier detection and improved outcomes. We examined the cost‐effectiveness of screening for NPC with plasma Epstein‐Barr virus DNA among Asian American men in the United States.Study DesignWe used a Markov cohort model to estimate discounted life‐years, quality‐adjusted life‐years (QALYs), costs, and incremental cost‐effectiveness ratios for screening as compared with usual care without screening.SettingThe base case analysis considered onetime screening for 50‐year‐old Asian American men.Subjects and MethodsConfirmatory testing was magnetic resonance imaging and nasopharyngoscopy. Cancer‐specific outcomes, health utility values, and costs were determined from cancer registries and the published literature.ResultsFor Asian American men, usual care without screening resulted in the detection of NPC at stages I, II, III‐IVB, and IVC among 6%, 29%, 54%, and 11% of those with cancer, respectively, whereas screening resulted in earlier detection with a stage distribution of 43%, 24%, 32%, and 1%. This corresponded to an additional 0.00055 QALYs gained at a cost of $63 per person: an incremental cost of $113,341 per QALY gained. In probabilistic sensitivity analysis, screening Asian American men was cost‐effective at $100,000 per QALY gained in 35% of samples.ConclusionAlthough screening for NPC with plasma Epstein‐Barr virus DNA for 50‐year‐old Asian American men may result in earlier detection, in this study it was unlikely to be cost‐effective. Screening may be reasonable for certain subpopulations at higher risk for NPC, but clinical studies are necessary before implementation.
Lipid metabolism genetic risk score interacts with the Brazilian Healthy Eating Index Revised and its components to influence the odds for dyslipidemia in a cross-sectional population-based survey in Brazil
Authors: Fujii Tatiane Mieko de Meneses , Norde Marina Maintinguer , Fisberg Regina Mara , Marchioni Dirce Maria Lobo , Rogero Marcelo Macedo 
Published: March 2019

Background: Dyslipidemia can be influenced by genetic and dietary risk factors. Aim: This study set out to investigate diet and genetic variations in Brazilian people in a cross-sectional population-based survey and to analyze the relationship between single nucleotide polymorphisms (SNPs) of genes involved in lipid metabolism and cardiometabolic-related phenotypes using a genetic risk score (GRS). Methods: We recruited 228 adults (mean age 36.5 years) who participated in the Health Survey of São Paulo (HS-SP), Brazil. Clinical and anthropometric parameters, as well as the interaction between the GRS and the Brazilian Healthy Eating Index Revised (BHEI-R) were evaluated. We analyzed the relationship between SNPs in APOA5 (rs662799), APOB (rs693, rs1367117), LDLR (rs688, rs5925) and LIPC (rs2070895, rs1800588) and cardiometabolic-related phenotypes using a GRS. Results: High-density lipoprotein cholesterol (HDLC) levels were associated with the BHEI-R ( p=0.026; β= −0.183) and with its SoFAAS component (solid fats, alcoholic beverages and added sugars) ( p=0.007; β=0.279). Non-HDL cholesterol levels were associated with the BHEI-R vegetable component ( p=0.015; β=0.002) and the meat, eggs and beans component ( p=0.003; β=0.007). Triacylglycerol levels were associated with the BHEI-R vegetable component ( p=0.027; β=0.003); the meat, eggs and beans component ( p=0.041; β=0.001); and the total protein component ( p=0.013; β=0.032). Significant effects were observed for the interactions between the GRS and both the BHEI-R oils component ( p=0.019) and the SoFAAS component ( p<0.001) on the dyslipidemia risk. Conclusions: The evaluation of dietary quality, especially fat quality, together with the lipid metabolism GRS could be a useful tool to manage cardiometabolic risk.
Sources and Factors Related to Oral Health-Care Information Among Dental Patients of a Teaching Hospital in Ibadan, Nigeria
Authors: Lawal Folake B. , Oladayo Abimbola M. 
Published: March 2019

Background The World Health Organization has described oral diseases as a global health problem in developing countries and this is mainly attributed to low level of oral health awareness. It, therefore, becomes imperative to investigate how people are informed about oral health care. Aim To determine the sources of oral health-care information and predictors of oral health awareness among individuals seeking dental care at a major tertiary health institution in sub-Saharan Africa. Methods A cross-sectional study was conducted among patients aged 16 years and older attending the dental outpatients of a major teaching hospital using structured questionnaires. Data obtained were analyzed with SPSS version 23. Results A total of 292 patients with a mean age of 38.4 ( SD = 16.3) years participated in the study of which 188 (64.4%) had been educated about oral health prior to the dental consultation. The major source of oral health-care information was dental clinics for 174 (92.6%) participants. The educators or resource persons were mainly dentists 105 (55.9%) and nurses or therapists 67 (35.6%). Females were more likely to have received oral health-care information (odds ratio [ OR] = 1.8, CI [1.1, 3.0], p = .021). Those with previous dental visits were also more likely to have received information about oral health care ( OR = 2.6, CI [1.6, 4.2], p < .001). Conclusion Dental clinics and dentists were the major sources of oral health-care information; being female and previous dental visits were significant positive predictors of being a recipient of oral health-care information. Dental public health education through mass and social media should be made a priority to improve access to oral health-care information.
Modélisation d’un processus de co-créativité : les apports du design et du management
Authors: Dampérat Maud , Jeannot Florence , Jongmans Eline , Jolibert Alain 
Published: March 2019

Résumé Cette étude a pour but d’améliorer le développement de nouveaux produits en fournissant aux praticiens et aux chercheurs une meilleure compréhension du processus de co-créativité via l’intégration des apports du design et du management à la démarche marketing. Elle propose et teste empiriquement un modèle de co-créativité basé sur les trois étapes du design thinking : (1) la définition des besoins, (2) la production des idées, et (3) le prototypage de la solution. Ce modèle étudie également l’influence de variables individuelles – empathie, familiarité avec le domaine, implication dans la tâche – sur le processus créatif. Les résultats valident le rôle médiateur des variables associées à la production d’idées entre la définition des besoins et le prototypage, ainsi que l’intérêt des variables individuelles sélectionnées. La validité prédictive du processus de co-créativité est testée via l’évaluation de la performance créative. Plusieurs domaines d’action sont proposés à chaque étape du processus de co-créativité, permettant aux organisations de stimuler la créativité de leurs équipes.
Pharmacist-led patient education and adverse event management in patients with non-small cell lung cancer receiving afatinib in a community-based, real-world clinical setting
Authors: Khrystolubova Natasha , Shieh Monica , Patel Anjan J , Bailey Ray 
Published: March 2019

Purpose To describe the outcomes of a pharmacist-led multi-center, collaborative patient education and proactive adverse event management program in a community-based oncology setting. Methods Patients with EGFR mutation-positive ( EGFRm+) non-small cell lung cancer, newly prescribed with oral afatinib, and monitored as part of the Florida Cancer Specialists patient management program, were included in a retrospective, observational analysis. During follow-up, data were collected on adverse event frequency, and changes in afatinib dosing. Data analyses were descriptive and exploratory in nature. Results The mean age of the 123 patients included in the analysis was 69 years, and 78% were female. At the time of the analysis, 3 patients had discontinued before receiving treatment, 89 patients had discontinued afatinib treatment, and 31 patients were continuing to receive afatinib treatment. The most common afatinib-related adverse events were diarrhea (85%), rash/skin reactions (58%), stomatitis/mucositis (19%), and paronychia (16%). Overall, 13% of patients discontinued due to afatinib-related adverse events. The median duration of treatment was 4 months in patients who discontinued due to adverse events, 6 months in those who discontinued for other reasons, and 18 months in those who were continuing to receive therapy. Afatinib dose-reductions were more frequent in patients continuing treatment versus those who discontinued due to adverse events (77% vs. 42%, respectively). Conclusions Findings suggest that adverse events in patients with EGFRm + non-small cell lung cancer receiving afatinib can be successfully managed in a community-based, real-world setting with the help of collaborative pharmacist-led patient education, adverse event monitoring, and continuous support.
Ophthalmic medicine regulatory approvals through the European Centralised Procedure, 1999–2017: Clinical efficacy considerations
Authors: Morgan-Warren Peter J 
Published: March 2019

Objectives:Regulatory approval of new medicines requires a thorough assessment of the potential clinical benefits and risks. Study end-points are expected to demonstrate a clinically relevant treatment effect that will translate into direct patient benefits. This study sought to review the ophthalmic medicines with European Union–wide approval granted via the Centralised Procedure and characterise the key efficacy end-points underpinning the demonstration of clinical benefit.Methods:This study was a retrospective review of published data pertaining to the European regulatory authorisation of centrally approved ophthalmic products between 1999 and 2017, inclusive. All sources and data consulted are in the public domain. European Public Assessment Reports published by the European Medicines Agency were consulted for data concerning the pivotal clinical efficacy studies supporting the applications. Data analyses were descriptive.Results:The European Medicines Agency have authorised 30 products via the Centralised Procedure between 1999 and 2017. For these products, a total of 24 additional approvals for line extensions or additional therapeutic indications were granted. Four products have been approved for orphan indications, including one approval ‘under exceptional circumstances’ and one ‘Conditional Marketing Authorisation’. Approvals for products in retina (36%) and glaucoma (28%) indications together accounted for the majority of authorisations, with trial end-points predominantly based on visual acuity and intraocular pressure parameters, respectively. Products were also approved for indications in ocular surface disease, inflammation, optic neuropathy and surgical adjuncts, with a range of functional and anatomical end-points.Conclusion:Approvals for ophthalmic medicines have been granted for a range of clinical indications, representing a considerable portion of available major therapeutics for practitioners. Benefit–risk assessments rely on clinical trial data demonstrating a clearly relevant patient benefit.
Comparison of intraocular pressure using Goldmann applanation tonometry versus non-contact tonometry in eyes with high-viscosity silicone oil
Authors: Pagoulatos Dionysios D , Kapsala Zoi G , Makri Olga E , Georgalas Ilias G , Georgakopoulos Constantinos D 
Published: March 2019

Background: To compare intraocular pressure (IOP) measurements using Goldmann applanation tonometer (GAT) and air tonometer (non-contact tonometry [NT]) in vitrectomized eyes with high-viscosity silicone oil tamponade, as well as in normal eyes. Patients and Methods: In this prospective comparative study, 32 eyes with silicone oil tamponade of high viscosity (5700 CS) and 32 normal fellow eyes were included. IOP was measured by GAT and air tonometer 30 ± 12 days after vitrectomy, while measurements of central corneal thickness (CCT) were also obtained. Results: In eyes with silicone oil, IOP was 20.09 ± 4.91 mmHg and 16.75 ± 3.86 mmHg using contact tonometer and air tonometer, respectively ( p < 0.0001). In normal eyes, IOP was 16.41 ± 2.15 mmHg and 16.31 ± 2.49 mmHg using the same tonometry techniques and this difference was not statistically significant ( p = 0.598). In addition, no significant correlation was detected between IOP measurements using both techniques and age, gender, CCT, and type of lens. Conclusions: It seems that GAT overestimates IOP in eyes with high-viscosity silicone oil compared with NT, while both IOP measurement techniques in normal eyes provide similar values. Further assessment of available IOP measurement methods could possibly establish the most accurate technique for IOP estimation in vitrectomized eyes with silicone oil tamponade.
Analysis of anatomical biomarkers in subtypes of diabetic macular edema refractory to anti-vascular endothelial growth factor treated with dexamethasone implant
Authors: Castro-Navarro Verónica , Cervera-Taulet Enrique , Navarro-Palop Catalina , Hernández-Bel Laura , Monferrer-Adsuara Clara , Mata-Moret Lucía , Montero-Hernández Javier 
Published: March 2019

Introduction: To analyze functional and anatomical outcomes in subtypes of diabetic macular edema treated with a single dexamethasone implant and to assess the usefulness of a pro-re-nata treatment among subtypes. Methods: Retrospective study in morphologic patterns of diabetic macular edema (diffuse retinal thickening n = 15; cystoid macular edema n = 38, and serous retinal detachment n = 17) recalcitrant to anti-vascular endothelial growth factor, treated with dexamethasone implant. Examinations included timing to recidive of diabetic macular edema, best-corrected visual acuity, and central subfield macular thickness at 2, 4, and 6 months. Results: In previously treated patients with a mean of 6.64 ± 3.69 anti-vascular endothelial growth factor injections, the best-corrected visual acuity improved from 61.64 ± 13.71 to 65.71 ± 14.65 as per the Early Treatment Diabetic Retinopathy Study protocol (p = 0.009) and central subfield macular thickness change from 447.46 ± 110.82 to 354.39 ± 80.46 µm (p < 0.005). The best-corrected visual acuity improvement was better in the diffuse retinal thickening group (68.67 ± 13.81 vs 65.26 ± 14.04 in cystoid macular edema and vs 64.12 ± 17.06 in serous retinal detachment), whereas higher central subfield macular thickness thinning was observed in serous retinal detachment group (368.47 ± 29.96 to 310.27 ± 67.47 in diffuse retinal thickening, vs 445.92 ± 105.06 to 364.39 ± 80.28 and 520.59 ± 122.96 to 370.94 ± 81.73 in cystoid macular edema and serous retinal detachment, respectively). Cystoid macular edema group was the group with more recurrences after 6 months (86.8% vs 66.7% in diffuse retinal thickening and 70.6% in serous retinal detachment). Conclusion: Dexamethasone implant is effective for all persistent diabetic macular edema subtypes with sustained functional and morphologic gains in the first 6 months.
Is Bangladesh’s Economy Approaching the Lewis Turning Point?
Authors: Bairagi Subir , Kamal Muntaseer 
Published: March 2019

During the last decade, Bangladesh economy grew consistently over 6 per cent annually; however, growth rate in the agriculture sector declined. Labour away from agriculture is evident; it is also evident real wages in the agriculture sector are rising. This could be an indication that Bangladesh is moving to a different stage of economic development. This article investigates whether Bangladesh is approaching a stage of economic development where marginal productivity of labour equals its price, called the Lewis turning point (LTP). We find that the reallocation of labour away from agriculture has had a positive but insignificant impact on economic growth in Bangladesh. We also find that the surplus agricultural labour has not fully been absorbed by the economy. Therefore, we conclude Bangladesh has yet to reach the LTP and suggest initiating policies (e.g., job creation in the service sector) that might speed up the country’s movement to the LTP. JEL: O11, O17, O41, O53
Nonoperative management of solid abdominal organ injuries: From past to present
Authors: Leppäniemi A. 
Published: March 2019

Background and aims: Today, a significant proportion of solid abdominal organ injuries, whether caused by penetrating or blunt trauma, are managed nonoperatively. However, the controversy over operative versus nonoperative management started more than a hundred years ago. The aim of this review is to highlight some of the key past observations and summarize the current knowledge and guidelines in the management of solid abdominal organ injuries. Materials and Methods: A non-systematic search through historical articles and references on the management practices of abdominal injuries was conducted utilizing early printed volumes of major surgical and medical journals from the late 19th century onwards. Results: Until the late 19th century, the standard treatment of penetrating abdominal injuries was nonoperative. The first article advocating formal laparotomy for abdominal gunshot wounds was published in 1881 by Sims. After World War I, the policy of mandatory laparotomy became standard practice for penetrating abdominal trauma. During the latter half of the 20th century, the concept of selective nonoperative management, initially for anterior abdominal stab wounds and later also gunshot wounds, was adopted by major trauma centers in South Africa, the United States, and little later in Europe. In blunt solid abdominal organ injuries, the evolution from surgery to nonoperative management in hemodynamically stable patients aided by the development of modern imaging techniques was rapid from 1980s onwards. Conclusion: With the help of modern imaging techniques and adjunctive radiological and endoscopic interventions, a major shift from mandatory to selective surgical approach to solid abdominal organ injuries has occurred during the last 30–50 years.