bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intervertebral Disc Degeneration and Low Back Pain: Molecular Mechanisms and Stem Cell Therapy
Authors: Meiliana Anna , Dewi Nurrani Mustika , Wijaya Andi 
Published: April 2018

BACKGROUND: Low back pain (LBP) mostly caused by disc degeneration, reflects to a tremendous of health care system and economy. More knowledge about these underlying pathologies will improve the opportunities that may represent critical therapeutic targets.CONTENT: Basic research is advancing the understanding of the pathogenesis and management of LBP at the molecular and genetic levels. Cytokines such as matrix metalloproteinases, phospholipase A2, nitric oxide, and tumor necrosis factor-α are thought to contribute to the development of LBP. Mesenchymal stem cells (MSCs) transplant to cartilage-like cells and secrete extracellular matrix and encourage nucleus pulposus (NP) cell activity inhibiting NP cell apoptosis, together with some chemical mediators such as cytokines and growth factors become a safe and effective new strategy for intervertebral disc degeneration (IDD) treatment and regeneration.SUMMARY: IDD occurs where there is a loss of homeostatic balance with a predominantly catabolic metabolic profile. A basic understanding of the molecular changes occurring in the degenerating disc is important for practicing clinicians to help them to inform patients to alter lifestyle choices, identify beneficial or harmful supplements, or offer new biologic, genetic, or stem cell therapies.KEYWORDS: low back pain (LBP), intervertebral disc (IVD), degeneration, nucleus pulposus (NP), annulus fibrosus (AF), extracellular matrix (ECM), genetic, stem cells
New Insight in The Molecular Mechanisms of Neurodegenerative Disease
Authors: Meiliana Anna , Dewi Nurrani Mustika , Wijaya Andi 
Published: April 2018

BACKGROUND: Redox and proteotoxic stress contributes to age-dependent accumulation of dysfunctional mitochondria and protein aggregates, and is associated with neurodegeneration. The free radical theory of aging inspired many studies using reactive species scavengers such as alpha-tocopherol, ascorbate and coenzyme-Q to suppress the initiation of oxidative stress. However, clinical trials have had limited success in the treatment of neurodegenerative diseases (NDDs).CONTENT: The misfolding and aggregation of specific proteins is a seminal occurrence in a remarkable variety of NDDs. In Alzheimer’s disease, the two principal aggregating proteins are β-amyloid (Aβ) and tau. The abnormal assemblies formed by conformational variants of these proteins range in size from small oligomers to the characteristic lesions that are visible by optica lmicroscopy, such as senile plaques and neurofibrillary tangles. Pathologic similarities with prion disease suggest that the formation and spread of these proteinaceous lesions might involve a common molecular mechanism, corruptive protein templating. The accumulation of redox modified proteins or organelles cannot be reversed by oxidant intercepting antioxidants and must then be removed by alternative mechanisms. Autophagy serves this essential function in removing damaged or dysfunctional proteins and organelles thus preserving neuronal function and survival.SUMMARY: Senescent cells and their senescence-associated secretory phenotypes (SASPs) may constitute a novel, understudied, and potentially important contributor to neuro-inflammation and subsequent neurodegeneration. Characterization of cellular senescence in the brain could uncover novel therapeutic targets for the prevention and treatment of chronic age-related NDDs.KEYWORDS: brain, aging, neurodegeneration, DNA damage, senescence, neuro-inflammation, mitochondria, lysosome, proteostasis, prion, amyloidosis
Direito à saúde e (in)eficácia sancionatória da Agência Nacional de Vigilância Sanitária: análise de casos de 2011 a 2015
Authors: Delgado Joedson de Souza , Gico Júnior Ivo Teixeira 
Published: April 2018

Resumo: Neste artigo investiga-se a ação fiscalizadora empreendida pela Agência Nacional de Vigilância Sanitária no exercício de polícia sanitária, no período de 2011 a 2015, apontado para um diagnóstico de (in)eficácia do julgamento das condutas dos particulares que cometem infrações. Trata-se da responsabilização do ilícito a ser apurado no processo administrativo sanitário realizado em diversos atos vinculados à declaração final da decisão colegiada. Baseia-se no levantamento de dados consolidados do Relatório Anual de Gestão de 2014 e 2015, confrontando-os com a legislação sanitária vigente, normativas internas e o atual debate doutrinário sobre a política sancionatória. Objetiva-se questionar a aptidão da Lei de Infrações à Legislação Sanitária (Lei n. 6.437/1977) para desestimular a prática de eventuais ilícitos, bem como da capacidade institucional para atuar na correção das irregularidades, ao mesmo tempo em que traz uma crítica acerca do (des)interesse da Diretoria Colegiada em tornar rápidos e eficazes a instrução, a análise e o julgamento dos feitos.Palavras-chave: Infração sanitária. Sanção. Penalidades sanitárias. Agência Nacional de Vigilância Sanitária. Relatório de gestão. Abstract: This article aims to investigate the auditing activity of Brazilian Health Regulatory Agency as a surveillance policy institution, from 2011 to 2015. This period is the target of a diagnosis of judgment (in)efficiency over surveillance violations. The research comprises the accountability for illicit acts, which have to be investigated during the surveillance administrative process, conducted in several acts bound to the final statement of a joint decision-making. It is also based on consolidated data of the Annual Management Report (2014-2015), comparing them to the current surveillance legislation, internal norms and the current doctrinaire debate about sanctioning policy. The objective is questioning the Law of Surveillance Violations (Law n. 6.437/1977) capacity to inhibit eventual surveillance illicit acts, as well as it comes up with a criticism regarding Board of Directors lack of interest in making the stages of the process – instruction, analysis and judgment – faster and more effective.Keywords: Sanitary Infraction. Sanction. Surveillance penalties. Brazilian Health Regulatory Agency. Management report.
Information Technology Adoption, Corporate Governance and Bank Performance
Authors: Muawanah Umi , Gunadi Gunadi 
Published: April 2018

Many academicians and practitioners have been acknowledging that information technology (IT) adoption could improve company performance. However, previous research indicates contradictory evidence. These inconsistencies can be attributed to variations among the studies in choosing proxy for IT adoption and due to contingent on other factors. This research aims at analyzing the influence of a contingent factor that is corporate governance (CG) concerning the effectiveness of IT adoption in influencing company performance measured by change in return on assets. Two proxies are used for IT adoption: company expenses on IT and the level of the organization managing IT. Data is collected and analyzed from annual reports of all banks listed in Indonesia Stock Exchange from 2011 to 2013. Multiple linear regression models are employed. This research shows that corporate governance practice could improve the effectiveness of IT adoption in improving company performance. This research implies that better CG practices in providing direction and monitoring on IT can lead to better company performance.
Special Issue on Intelligent Computation in Design and Manufacturing
Authors: Teti Roberto , Le Masson Pascal , Matsumoto Mitsutaka , Ullah AMM Sharif 
Published: April 2018

To solve problems underlying design and manufacturing we often rely on methodologies of computational intelligence such as machine learning, artificial neural networks, fuzzy logic, fuzzy inference systems and smart optimization algorithms. In this Special Issue of the International Journal of Automation Technology, original articles are presented with reference to the engagement of intelligent computation in diverse application areas of design and manufacturing, including manufacturing process monitoring, manufacturing systems management, scheduling, design theory and methodology.
The six research papers in this Special Issue propose the use of intelligent computation methodologies to deal with various topics related to manufacturing and design. In particular, the first three papers focus on manufacturing process monitoring with reference to different manufacturing technologies, including tool wear monitoring in drilling of composite materials, sensor monitoring in CNC turning and residual stress prediction in welding. Diverse intelligent approaches such as artificial neural networks and adaptive neuro-fuzzy inference systems are proposed to support manufacturing process monitoring. The fourth paper deals with the manufacturing system level, proposing the employment of a solution algorithm combining metaheuristics and operation simulation for scheduling of production processes. The fifth paper aims at developing tools to guide the manufacturers to manage the technology investment and cost saving target for customer satisfaction based on the application of internet of things. The last paper proposes a methodology to support the introduction of customer requirements in product and service design via a decision support system which exploits artificial intelligence algorithms (machine learning) based on inductive inference, allowing knowledge related to product/service to be mapped, structured and managed to design the service and product semantic model.
The editors deeply appreciate all the authors and anonymous reviewers for their effort and excellent work to make this Special Issue unique. We hope that future research on intelligent computation in manufacturing and design will advance manufacturing technology and systems as well as design methodologies.
Persepsi Guru Sejarah Terhadap Implementasi Kurikulum 2013 pada Mata Pelajaran Sejarah: Survei Guru Sejarah di SMAN Se-Jakarta Barat
Authors: Romdannur M , Fakhrudin M 
Published: April 2018

This study aims to analyze the perceptions of history teachers on the implementation of the Kurikulum 2013 on the subject of history by surveying the history teachers in West Jakarta Senior High School. This study used survey research method with data collection techniques through questionnaires distribution to teachers of history subjects in West Jakarta Senior High School which amounted to 48 respondents. The result of this research is perception of history teacher in West Jakarta Senior High School about implementation of Kurikulum 2013 have very good perception about Kurikulum 2013 with percentage 88,27%. It can be said that the history teacher can receive, understand, and know the Curriculum change from Kurikulum 2006 (KTSP) to Kurikulum 2013

Penelitian ini bertujuan untuk menganalisis persepsi guru sejarah terhadap implementasi Kurikulum 2013 pada mata pelajaran sejarah dengan mensurvei guru sejarah yang ada di SMAN wilayah Jakarta Barat. Penelitian ini menggunakan metode penelitian survei dengan teknik pengumpulan data melalui penyebaran kuesioner kepada guru-guru mata pelajaran sejarah yang ada di SMAN wilayah Jakarta Barat yang berjumlah sebanyak 48 responden. Hasil dari penelitian ini adalah persepsi guru sejarah SMA Negeri di wilayah Jakarta Barat mengenai implementasi Kurikulum 2013 memiliki persepsi yang sangat baik tentang Kurikulum 2013 dengan presentase 88,27%. Hal ini dapat dikatakan bahwa guru sejarah dapat menerima, memahami, dan mengetahui adanya perubahan Kurikulum dari Kurikulum 2006 (KTSP) menjadi Kurikulum 2013.
Hygienic quality of public natural swimming pools (NSP)
Authors: Bruns Stefan , Peppler Christina 
Published: April 2018

Abstract
Natural swimming pools (NSP) have become more popular in the past 20 years, both for private and public use, but their hygienic status remains a matter of discussion. Elimination rates in NSP are well defined for Escherichia coli, enterococci and Pseudomonas but a lack of knowledge exists regarding elimination rates in NSP concerning the parasitic protozoans Giardia and Cryptosporidium. First studies indicate that in-situ zooplankton filtration proved to reduce these protozoans efficiently: the in-situ elimination of Cryptosporidium is dependent on the population of zooplankton. In the 50% percentile the elimination rate is four times faster than in the chlorinated pool. The ex-situ elimination of Cryptosporidium in an NSP is approximately 10% faster than in a chlorinated pool. In ex-situ treatment of NSP the elimination rate reached 2 log-steps versus 1 log-step in chlorinated pools. For the further development of NSP for the best possible hygiene and health status some elementary questions, stated in this paper, will have to be solved in the next years or decades. This work describes the in-situ (water treatment inside the pool) and ex-situ water treatment (water treatment via external water treatment plants) of NSP, and the influence of zooplankton in existing NSP on the elimination rate of Cryptosporidium and Giardia.
Comparison of SVM, ANFIS and GEP in modeling monthly potential evapotranspiration in an arid region (Case study: Sistan and Baluchestan Province, Iran)
Authors: Mohammadrezapour Omolbani , Piri Jamshid , Kisi Ozgur 
Published: April 2018

Abstract
Evapotranspiration is an important component in planning and management of water resources. It depends on climatic factors and the influence of these factors on each other makes evapotranspiration estimation difficult. This study attempts to explore the possibility of predicting this important component using three different heuristic methods: support vector machine (SVM), adaptive neuro-fuzzy inference system (ANFIS) and gene expression programming (GEP). In this regard, according to the Food and Agriculture Organization of the United Nations (FAO) Penman-Monteith equation, the monthly potential evapotranspiration in four synoptic stations (Zahedan, Zabol, Iranshahr, and Chabahar) was calculated using monthly weather data. The weather data were then used as inputs to the SVM, ANFIS and GEP models to estimate potential evapotranspiration. Five different input combinations were tried in the applications. The results of SVM, ANFIS and GEP models were compared based on the coefficient of determination (R2), mean absolute error and root mean square error. Findings showed that the SVM model, whose inputs are average air temperature, relative humidity, wind speed, and sunny hours of the current and one previous month, performed better than the other models for the Zahedan, Zabol, Iranshahr, and Chabahar stations. Comparison of the three heuristic methods indicated that in all stations, the SVM, GEP and ANFIS models took first, second, and third place in estimation of the monthly potential evapotranspiration, respectively.
Decoloration of waste PET alcoholysis liquid by an electrochemical method
Authors: Li Yanyan , Li Mengjuan , Lu Jing , Li Xiaoqiang , Ge Mingqiao 
Published: April 2018

Abstract
Disperse Red 60 simulated polyester alcoholysis liquid decoloration by electro-Fenton with Fe3O4 catalyst was studied. The inﬂuences of the main operating parameters such as catalyst dosage (0.3–0.9 g/L), current density (60–120 mA/cm2) and pH (1–7) were optimized by response surface methodology (RSM) based on Box–Behnken surface statistical design (BBD). In optimal conditions, the initial concentration of 25 mg/L disperse red polyester alcoholysis liquid was catalyzed by 0.6 g/L Fe3O4, and the decoloration efficiency was 97.18% with the current density of 90 mA/cm2 and initial pH of 4.6. There was a relative error of 1.18% with the predicted model when the predictive value was 98.25% under the same conditions. In addition, ultraviolet-visible absorption spectra (UV-Vis), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) were used to study the degradation mechanism during decoloration. The intermediates were identiﬁed and the proposed degradation pathways were investigated by liquid chromatography-mass spectrometry (LC-MS) analysis.
Performance evaluation of anaerobic baffled reactor (ABR) for treating alkali-decrement wastewater of polyester fabrics at incremental organic loading rates
Authors: Yang Bo , Xu Hui , Wang Junfeng , Yan Dengming , Zhong Qijun , Yu Hexin 
Published: April 2018

Abstract
In this study, an anaerobic baffled reactor (ABR) with four compartments was employed to treat alkali-decrement wastewater of polyester fabrics under different organic loading rates. The stable operation of this reactor was achieved in 70 days at a hydraulic retention time of 36 h and mesophilic temperature of 35 ± 1 °C. It is found that the chemical oxygen demand removal and decolorization of this system can be as high as 79.0% and 87.7%, respectively. The different acidogenesis and methanogenesis in four compartments was acclimated by the variation of pH, oxidation reduction potential values and operational conditions in the spatial distribution of the first to fourth compartments of the ABR system. In addition, the dehydrogenase activity (DHA) and coenzyme F420 concentrations along the four compartments ranged from 67.8 to 185.21 μgTF/(gVSS·h) (TF: triphenyl formazan; VSS: volatile suspended solids) and 0.123 to 0.411 μmol/g, respectively. These results indicated that the ABR could separate acidogenesis and methanogenesis in longitudinal distribution and treat well the alkali-decrement wastewater.
Sistem Pengukuran Modulus Elastisitas Beton Menggunakan Metode Ultrasonic Pulse Velocity
Authors: Purwanto Amanda , Ro’uf Abdul 
Published: April 2018

Modulus of elasticity of concrete usually measured by Destructive Testing which is not considered as an effective way, because It will destroy the concrete. Ultrasonic Pulse Velocity can be a solution to measure value of modulus of elasticity without destructing it. The concept of the system is to look for velocity of wave, then put the value into modulus elasticity formula.UPV system will transmit ultrasonic wave through concrete. HC-SR04 used for generating 40 kHz wave, increasing voltage of wave on receiver, and calculating time travel. The voltage of wave sent by HC-SR04 is only about 10 volt, so that power and voltage of wave has to be amplified. Piezoelectric is used as a transducer which can converts electrical to mechanical energy. The results of this research shows that error value on wave velocity measurement have an average value for about 18,2% compared to result of UPV Pundit. Static modulus of elasticity from compressive test is compared to value of dynamic modulus of elasticity that is obtained by UPV system with HC-SR04. Ratio between two values is about 45% - 249%.
Perancangan Flowmeter Ultrasonik untuk Mengukur Debit Air Pada Pipa
Authors: Robhani Hidayahtullah Abdi , Ro'uf Abdul 
Published: April 2018

Measurement of water discharge using ultrasonic wave properties ensures the stability of measured water profile because of its non-intrusive nature. In this study, a water discharge measuring device has been developed by utilizing ultrasonic wave properties to determine its speed. The device is designed using two pairs of ultrasonic transmitters and receivers at upstream and downstream positions toward the direction of the water flow. 40 kHz ultrasonic waves are generated with AD9850 DDS sinusoidal pulse generating module. The sensor data processor uses an Arduino Due microcontroller module by calculating the measured ultrasonic wave travel time difference. Measurements were made on a 57 mm diameter pipe with flow rates varied using 25%, 50%, 75%, and 100% tap openings. The measurement resulte shows the lowest water debit calculation value of 4.42×10-4 m3/s at 25% faucet opening and highest discharge of 2.15×10-3 m3/s at 100% faucet opening with the values of coefficient of correlation and coefficient of determination on 25%, 50%, 75% and 100% faucet openings respectively 0.9715, 0.9669, 0.9604 and 0.9647 and 94.37%, 93.49%, 92 , 24%, and 93.07%.
Rol de los profesionales de enfermería en el sistema de salud colombiano
Authors: De Arco-Canoles Oneys Del Carmen , Suarez-Calle Zuleima Karina 
Published: April 2018

Introducción: El profesional de enfermería es capaz de brindar cuidados a personas y comunidades, desde los diferentes roles que asume en el sistema de salud y que inciden en la calidad de vida de la sociedad. Objetivo: identificar en la evidencia científica publicada entre 2011 y 2017 el rol de enfermería en el sistema de salud. Materiales y Métodos: La búsqueda bibliográfica se realizó en las bases de datos SciELO, PubMed, LILACS y ScienceDirect, se seleccionaron artículos completos, en español e inglés que presentaron en el título los descriptores: “enfermería” “rol de enfermería” “sistemas de salud” “practica avanzada del profesional”. Resultados: Se seleccionaron cincuenta estudios publicados entre los años 2011 a 2017, que estudiaron los sistemas de salud en Latinoamérica, buscando orientar el rol de enfermería; resultando tres categorías de interés: prácticas en el ámbito hospitalario, prácticas en el ámbito comunitario y la gestión docencia e investigación. Conclusión: A pesar de la importancia del rol que desempeñan los profesionales de enfermería en Colombia, no se observa una diferenciación de perfiles y funciones dentro del equipo sanitario, por tanto, es preciso delimitar algunas funciones, recuperar campos de acción, afianzar el liderazgo, la autonomía y la humanización en la prestación de los servicios.
PEDRO AMÉRICO E O NACIONALISMO ROMÂNTICO CONSERVADOR
Authors: Vasconcelos Lúcio Flávio Sá Peixoto de 
Published: April 2018

As telas de Pedro Américo que retratam a Guerra do Paraguai (1864-70) impressionam pela grandiosidade, perfeccionismo e impacto visual, além de contribuírem para o prestígio político do exército brasileiro. Por meio das suas pinturas históricas de cunho cívico, o nacionalismo forjado no Paço Imperial ganhou expressão artística, auxiliou a estruturar o Estado brasileiro e se cristalizou no imaginário popular. Seu quadro mais famoso, Proclamação da Independência, passou a fazer parte da formação cultural e política de várias gerações e é reconhecido por todos os brasileiros minimamente letrados.
Palavras-Chave
Nacionalismo – Romantismo – Império

Pedro Américo and the Conservative Romantic Nationalism

ABSTRACT: Pedro Americo's canvases portraying the Paraguayan War (1864-70) overwhelm by the greatness, perfectionism and visual impact, besides contributing to the political prestige of the Brazilian Army. Through his historical paintings with civic hallmarks, the nationalism forged in the Imperial Palace won artistic expression, assisted the structuring of the Brazilian State and crystallised into the popular imagery. His most famous painting, Proclamation of Independence, came out to take part in the political and cultural formation of several generations and it is acknowledged by all Brazilians minimally literate.

KEY-WORDS: Nationalism - Romanticism – Empire