bluuebunny/crossref_metadata_2025_split huggingface dataset:
2-LB: CGM-Based Clinical Targets: Recommendations from the International Consensus on Time-in-Range (TIR)
Authors: BATTELINO TADEJ , DANNE THOMAS , PHILLIP MOSHE ,   FOR THE INTERNATIONAL CONSENSUS ON TIR TARGETS
Published: June 2019

Due to increasing CGM accuracy, longer lasting glucose sensors and better reimbursement, CGM use is expanding. Yet there is still room for improvement in glucose management across all types of diabetes. One strategy to enhance CGM effectiveness is to establish clear targets for CGM metrics that diabetes care teams and people with diabetes can work together to achieve. Professional diabetes associations recently endorsed accepted core CGM metrics. The International Consensus on TIR targets, convened in February 2019, proposes clear CGM targets for time-in-range, time-below-range and time-above-range to help guide safe and effective therapy. The proposed CGM targets, based on data from large pre-CGM clinical trials and CGM randomized controlled trials, are shown in the Table. The group recommends a standardized CGM report incorporating key CGM metrics and targets along with a 14-day composite glucose profile to be an integral component of clinical decision making. The ambulatory glucose profile (AGP) represents such a standard CGM report. When patients endeavor to reach the proposed TIR targets, particularly for children and adolescents, one should emphasize that each 5% incremental increase in TIR is clinically beneficial. The CGM targets and standardized profile proposed by the International TIR Consensus may facilitate the routine use of CGM and improve clinical outcomes of diabetes management.

Disclosure
T. Battelino: Advisory Panel; Self; Eli Lilly and Company, Medtronic, Novo Nordisk A/S, Sanofi. Consultant; Self; Eli Lilly and Company, Sanofi. Research Support; Self; JDRF, National Institute of Diabetes and Digestive and Kidney Diseases. Speaker’s Bureau; Self; Abbott, Eli Lilly and Company. Stock/Shareholder; Self; DreaMed Diabetes. T. Danne: Advisory Panel; Self; Abbott, AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Lilly Diabetes, Medtronic, Novo Nordisk A/S, Roche Diabetes Care, Sanofi-Aventis. Speaker’s Bureau; Self; Dexcom, Inc. M. Phillip: Consultant; Self; Qulab Medical, RSP Systems A/S. Research Support; Self; Bristol-Myers Squibb Company, Dexcom, Inc., JDRF, Lexicon Pharmaceuticals, Inc., Merck #x0026; Co., Inc., OPKO. Stock/Shareholder; Self; DreaMed Diabetes, Ltd., NG Solutions Ltd., Nutriteen Professional Ltd. Other Relationship; Self; AstraZeneca, Eli Lilly and Company, Insulet Corporation, Medtronic MiniMed, Inc., Novo Nordisk A/S, Pfizer Inc., Sanofi-Aventis.

Funding
Advanced Technologies and Treatments for Diabetes
83-OR: Distinct Growth Phases in Early Life Associated with Risk of Type 1 Diabetes Prodrome: The TEDDY Study
Authors: LIU XIANG , VEHIK KENDRA , HUANG YANGXIN , LARSSON HELENA ELDING , TOPPARI JORMA , ZIEGLER ANETTE , SHE JIN-XIONG , REWERS MARIAN , HAGOPIAN WILLIAM , AKOLKAR BEENA , KRISCHER JEFFREY ,   THE TEDDY STUDY GROUP
Published: June 2019

This study investigates two-phase growth patterns in early life and their associations with development of islet autoimmunity (IA) and type 1 diabetes (T1D).
There were 7521 genetically high-risk children from Sweden, Finland, U.S. and Germany followed from birth for a median of 9.0 (IQR 5.7-10.6) years with available growth data. Of these, 761 children developed IA and 290 children progressed to T1D. Bayesian two-phase piecewise linear mixed models with a random change point were used to evaluate distinct growth phases in early life (Figure 1). Cox proportional hazard models were used to assess growth phase effects on risk of IA and progression to T1D. A higher rate of weight gain (kg/year) in the first phase was associated with an increased IA risk (HR =1.10, 95% CI 1.02, 1.18). A height growth pattern with a slower growth rate (cm/year) in the first phase, a higher growth rate in the second phase and younger age (months) at the phase transition was associated with an increased risk of progression from IA to T1D (HR=0.80, 95% CI 0.70, 0.91; HR=1.47, 95% CI 1.21, 1.78; HR=0.69, 95% CI 0.52, 0.93, respectively). A higher rate of weight gain in the second phase was associated with an increased risk of progression from IA to T1D (HR=2.54, 95% CI 1.36, 4.74) in children with first appearing GADA-only.
Considering growth by phases in early life better clarified how specific growth phases contribute to the risk of IA and T1D.

Disclosure
X. Liu: None. K. Vehik: None. Y. Huang: None. H. Elding Larsson: None. J. Toppari: None. A. Ziegler: None. J. She: None. M. Rewers: None. W. Hagopian: Research Support; Self; Novo Nordisk A/S. B. Akolkar: None. J. Krischer: None.

Funding
National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; Centers for Disease Control and Prevention; JDRF; University of Florida (UL1TR000064); University of Colorado (UL1TR001082)
3D Modal Analysis of a Loaded Tire with Binary Random Noise Excitation
Authors: Ferhat Ipar , Sarlo Rodrigo , Tarazaga Pablo A. 
Published: June 2019

ABSTRACT
Modal analysis of tires has been a fundamental part of tire research aimed at capturing the dynamic behavior of a tire. An accurate expression of tire dynamics leads to an improved tire model and a more accurate prediction of tire behavior in real-life operations. Therefore, the main goal of this work is to improve the tire-testing techniques and data range to obtain the best experimental data possible using the current technology. With this goal in mind, we propose novel testing techniques such as piezoelectric excitation, high-frequency bandwidth data, and noncontact vibration measurement. High-frequency data enable us to capture the coupling between the wheel and tire as well as the coupling between airborne and structure-borne noise. Piezoelectric excitation eliminates the dynamic coupling of shakers and the inconsistency of force magnitude and direction of impact hammers as well as added mass effect. Noncontact vibration measurements using three-dimensional (3D) scanning laser Doppler vibrometer (SLDV) are superior to accelerometers because of no mass loading, a high number of measurement points in three dimensions, and high sensitivity. In this work, a modal analysis is carried out for a loaded tire in a static condition. Because of the highly damped nature of tires, multiple input excitation with binary random noise signal is used to increase the signal strength. Mode shapes of the tire are obtained and compared using both accelerometers and SLDV measurements.
Solar Radiation Projections of Cmip5 Models for South of Brazil
Authors: Bierhals Elison Eduardo , Pereira Francisco , Brazil Claudinéia , Rossini Elton 
Published: June 2019

The most critical factors in the acceleration of climate and environmental changes are related to industrial development and consequently to an increase in the demand for electricity. Looking for measures that minimize impacts on the environment, alternative energy sources are gaining more and more space in the Brazilian energy matrix. Brazil presents a great solar potential for the generation of electric energy, so the knowledge of solar radiation and its characteristics are fundamental for the study of energy use. Due to the above, this article aims to verify the climatic variability corresponding to the variations in solar radiation patterns, in the face of climate change scenarios. The database used in this research is part of the Phase 5 Intercomparison of Matching Models (CMIP5). It is important, first of all, to determine its availability in order to enable the use of solar radiation as a source of energy in a given location and/or region. The climatic projections, based on the pessimistic scenario, in a 75-year period (2026-2100) showed a fall in solar radiation in all of Rio Grande do Sul, reaching 12% in the eastern region of the state. A concern with the factors that influence the pessimistic perspectives of this scenario, as it may affect a possible production of electric energy from solar radiation.
Выставочная деятельность Национального музея Тувы в 1991–2018 гг.
Authors: Dyrtyk-ool Anna O. , Martynov Anatoly I. 
Published: June 2019

В статье анализируются основные тенденции выставочной деятельности Национального музея Тувы в постсоветское время: в 1990-е, 2000-е и 2010-е годы. С начала 1990-х годов изменились роль и место музеев в бывшем советском обществе, в том числе и в Туве. Изменение социокультурной ситуации повлекло за собой критическое осмысление исторического процесса, пересмотр памятников базы музеев, поиск новых тенденций музейной коммуникации. Осложняло дело отсутствие новых данных, но появилась возможность самостоятельно творчески организовывать проекты.С 1992 по 2000 гг. музей имел практически постоянный рост стационарных выставок и регулярно проводил передвижные в различных учебных заведениях, организациях, предприятиях Кызыла и районах республики. На стационарных выставках в эти годы музей акцентировал основное внимание на материалах, посвященных юбилейным датам известных личностей (в основном представителей тувинской культуры) и исторических событий. На передвижных выставках экспонировались разнообразные темы о материальной и духовной культуре тувинского народа, периодически — рисунки Нади Рушевой. Интересные события в жизни Тувы также нашли отражение в работе музея.С 2001 по 2018 гг. музей активизирует свою работу каждый год. Дан обзор самых значительных выставок этих лет, дается их классификация и краткий обзор каждого типа. Тематически наиболее популярными в республике и за ее пределами являются выставки, посвященные жизни и творчеству Нади Рушевой, материальной и духовной культуре тувинского народа, декоративно-прикладному искусству Тувы.Источниковой базой исследования выступила музейная документация, в состав которой входят научные концепции, тематико-экспозиционные планы и отчеты.
Habitus e hip hop
Authors: Chultz Gabriela , Silva Suzane Weber da 
Published: June 2019

Neste artigo, buscamos descrever de que forma certas incorporações sociais, culturais e de classe tornam-se visíveis através de gestos e podem sugerir escolhas coreográficas. Empregamos como fundo reflexivo uma criação coreográfica com jovens alunos de escola pública, promovendo elementos da dança hip hop como catalisadora gestual. Propomos uma reflexão em dança, mobilizando conceitos de Pierre Bourdieu tais como campo, capital e habitus, dando ênfase à relação entre corpo social e o corpo dançante.
Globalization and Macroeconomic Instability: Evidence from Unemployment in Pakistan
Authors: Ali Amjad , Khan Zilakat , Ali Sher 
Published: June 2019

Growing population in the present globalized world is a challenge for the developing to engage the increasing labour force in productive environment. The creation of new employment opportunities is not easy to handle with existing resources (lack of capital both physical and financial) and became a more intense challenge for policy maker. Fairley free transaction also affect employment/unemployment in developing countries. Therefore, this study aimed to examine the impact of globalization on unemployment in case of Pakistan for the period of 1980-2017. Globalization is measured by three different forces i.e. Trade flows, FDI flow and Remittances flow. To estimate the responsiveness of unemployment to globalization ARDL co-integration techniques is employed. Bound test confirmed co-integration relationship between the variables under consideration. The results of short run and long run estimates showed that globalization forces affected unemployment in Pakistan. Globalization in the shape of trade affects unemployment directly while the impact of remittances is negative to unemployment. The impact of FDI is positive but insignificant.
Therefore, this study suggests that proper attention should be paid toward policy formulation regarding trade and remittances inflow to increase employment opportunities in Pakistan. Globalization should be perused with adequate policies that will certainly smooth macroeconomic environment of Pakistan.
Identifikasi Pseudomonas aeruginosa dan Uji Sensitivitas terhadap Antibiotik dari Sampel Pus Infeksi Luka Operasi di RSUD Dr. Moewardi
Authors: Sulviana Aulia Wahyu , Puspawati Nony , Rukmana Rizal Maarif 
Published: June 2019

Infeksi luka operasi merupakan bagian dari infeksi nosokomial. Salah satu bakteri penyebab tertinggi infeksi luka operasi adalah Pseudomonas aeruginosa. Penelitian ini bertujuan untuk mengetahui adanya Pseudomonas aeruginosa pada sampel pus infeksi luka operasi dari Rumah Sakit Umum Daerah Dr. Moewardi dan untuk mengetahui pola sensitivitasnya terhadap beberapa antibiotik.
Jenis penelitian ini adalah penelitian analitik observasional dengan pendekatan cross sectional. Bakteri Pseudomonas aeruginosa yang telah diisolasi dari sampel pada media Pseudomonas Selective Agar lalu dilakukan pengecatan Gram dan uji biokimia, kemudian dilakukan uji sensitivitas terhadap beberapa antibiotik yaitu: siprofloksasin, seftriakson, meropenem, sefotaksim, gentamisin, dan tobramisin dengan metode difusi Kirby Bauer. Hasil diameter zona hambat pada uji sensitivitas dibandingkan dengan standar diameter zona hambat menurut Clinical Laboratory Standard Institute.
Hasil penelitian menunjukkan bahwa dari 45 sampel pus infeksi luka operasi di Rumah Sakit Umum Daerah Dr. Moewardi teridentifikasi 11 sampel positif Pseudomonas aeruginosa. Hasil uji sensitivitas menunjukkan bahwa Pseudomonas aeruginosa sensitif 100% terhadap meropenem. Hasil uji sensitivitas menunjukkan sensitif 90,90% terhadap siprofloksasin, tobramisin dan gentamisin. Hasil uji sensitivitas menunjukkan sensitif 63,63% pada seftriakson dan hasil uji sensitivitas menunjukkan sensitif 9,09% pada sefotaksim.
The Effect of Loading during Martensitic Transformation of a Maraging Steel after Prior Austenite Grain Size Refinement by Thermal Cycling
Authors: Petersmann M. , Antretter T. , Sannikov A. , Sartory B. , Ehlenbröker U. 
Published: June 2019

Abstract
This work demonstrates the efficiency of microstructural tuning by external loading during the martensitic phase transformation of a 12Cr-9Ni-2Mo-0.7Al-0.35Ti maraging steel. Additional prior austenite grain size refinement is achieved by thermal cycling yielding industrially relevant grain sizes, for which not the full set of all 24 characteristic Kurdjumov-Sachs orientation relation variants of martensite is obtained within each grain. For the last thermal cycle three different cases are investigated: i) one specimen is annealed at a higher temperature before the last cooling, ii) one specimen is loaded with a tensile stress of 120 MPa and iii) one specimen with an equivalent 120 MPa Mises stress in torsion during the transformation. This study is one of the first combining the effects of a small grain size, a high dislocation density and external loadings. Orientation imaging microscopy data is presented, revealing the effect of loading type during transformation on the final texture and interface/boundary character.
Sample Preparation Challenges with Highly Metastable Ferritic-Austenitic Stainless Steels
Authors: Uusikallio S. , Jaskari M. , Kisko A. , Nyo T. , Porter D. , Kömi J. 
Published: June 2019

Abstract
The effects of different sample preparation techniques on a set of laboratory hot-rolled and thermally cycled ferritic-austenitic stainless steels containing 19 – 20 wt.% Cr have been studied. The differences in chemical composition led to different volume fractions of ferrite and austenite and austenite stabilities, which were characterized using composition-based estimates of Md30 and Ms temperatures. The sample preparation methods were combined mechanical and chemical polishing, electrolytical polishing and ion beam cross section polishing. The ferrite-austenite phase ratio and tendency for phase transformation varied with the chemical composition of the steel. Electropolishing is shown to be the only sample preparation method not to cause martensite formation in samples containing metastable austenite.
Особливості лабораторно-діагностичних показників у хворих різних вікових груп з гострим коронарним синдромом з елевацією сегмента ST
Authors: Parkhomenko O. M. , Lutay Ya. M. , Bilyi D. O. , Irkin O. I. , Stepura A. O. , Kushnir S. P. , Skarzhevskyi O. A. 
Published: June 2019

The aim – to find out the features of laboratory diagnostic indicators in patients of different age groups with ST-elevation acute coronary syndrome.Materials and methods. Were analyzed the data of 835 patients admitted to the emergency departments from January 2000 to December 2015, with ST-elevation acute coronary syndrome. Patients were divided into the two groups depending on age: I group – patients < 45 years of age (n=189), II group ≥ 45 years (n=646).Results and discussion. In young patients, hemoglobin and platelet levels were significantly higher throughout the observation period. Initial ALT and AST were significantly higher in young patients on day 1 (p<0.001 and p<0.01, respectively), but didn’t differ further. Baseline glucose level in patients < 45 years of age was significantly lower than in the older group (p<0.05). Patients < 45 years had higher values of fibrinogen (p=0.048). Young adults had lower total cholesterol, LDL at baseline (p<0.05) and the day 7 (p<0.001). Patients of 1 group showed higher HDL-C and TG (p<0.05). Probable FH was more common in the patients <45 years (7.34 and 1.32 %, p<0.05), in spite of lower HDL (3.47±0.12 and 3.83±0.08 mmol/l, p<0.05).Conclusions. The most significant risk factors for a MI at a young age are dyslipidemia and increased TG even in the absence of hypercholesterolemia. When allocating the group of familial hypercholesterolemia in patients with myocardial infarction at a yo≤ung age, familial hypercholesterolemia is observed significantly more often. The development of MI at a young age is often accompanied by an increase in the level of fibrinogen, hemoglobin and platelets, which may have a prothrombogenic effect.
Body mass index, haemoglobin status and eating behaviours among adolescents in Jazan, Saudi Arabia: A cross-sectional study
Authors: Moukhyer Mohamed E. , Mukhayer Aziza , Elfaki Fatima A. , Salih Mahfouz Mohamed 
Published: June 2019

BACKGROUND: A balanced nutrition is vital for healthy growth and development. Recently increasing attention is paid globally for adolescent nutritional profile and eating patterns. The main objectives of this study are to define the prevalence of obesity, overweight, thinness, and anemia and to describe the distribution of nutritional problems among the participants of the study in Jazan City, southwest Saudi Arabia. METHODOLOGY: An observational cross-sectional study was conducted to characterize the basic health behavior and nutritional status among adolescents. A total of 502 school-going adolescents were recruited for this study, within the age group 12–19 years from intermediate and high schools in Jazan City. RESULT: The total prevalence of obesity was 13.9%, 16.4%, and 10.6% for males and females, respectively. Adolescents with normal weight accounted for almost 53.2%, with no significant difference between males and females. The overall prevalence of anemia was 44.16%. The prevalence was higher in male (50.0%) than in female (40.4%) adolescents. Regarding the importance of breakfast, 66.3% of the males and 52.6% of the females think that breakfast is a necessary meal, with a significant difference between the males and the females. Significant differences were reported for 16 food items. For the food items liver, goat’s meat, eggs, milk, yogurt, white rice, mango, tangerine, fruit juices, honey, sausage, carrots, and coffee, the boys were more consumers than girls. CONCLUSION: The prevalence of overweight and anemia corresponds to the other findings in the region. Eating behaviors vary particularly with regard to breakfast, the most important meal for adolescents aged 12–19 years. Any intervention to overcome these problems could be achieved by nutrition promotion and individual approach among adolescents themselves for behavior change at school and community levels.
Improving coding and primary care management for patients with chronic kidney disease: an observational controlled study in East London
Authors: Hull Sally A , Rajabzadeh Vian , Thomas Nicola , Hoong Sec , Dreyer Gavin , Rainey Helen , Ashman Neil 
Published: June 2019

BackgroundThe UK national chronic kidney disease (CKD) audit in primary care shows diagnostic coding in the electronic health record for CKD averages 70%, with wide practice variation. Coding is associated with improvements to risk factor management; CKD cases coded in primary care have lower rates of unplanned hospital admission.AimTo increase diagnostic coding of CKD (stages 3–5) and primary care management, including blood pressure to target and prescription of statins to reduce cardiovascular disease risk.Design and settingControlled, cross-sectional study in four East London clinical commissioning groups (CCGs).MethodInterventions to improve coding formed part of a larger system change to the delivery of renal services in both primary and secondary care in East London. Quarterly anonymised data on CKD coding, blood pressure values, and statin prescriptions were extracted from practice computer systems for 1-year pre- and post-initiation of the intervention.ResultsThree intervention CCGs showed significant coding improvement over a 1 year period following the intervention (regression for post-intervention trend P<0.001). The CCG with highest coding rates increased from 76–90% of CKD cases coded; the lowest coding CCG increased from 52–81%. The comparison CCG showed no change in coding rates. Combined data from all practices in the intervention CCGs showed a significant increase in the proportion of cases with blood pressure achieving target levels (difference in proportion P<0.001) over the 2-year study period. Differences in statin prescribing were not significant.ConclusionClinically important improvements to coding and management of CKD in primary care can be achieved by quality improvement interventions that use shared data to track and monitor change supported by practice-based facilitation. Alignment of clinical and CCG priorities and the provision of clinical targets, financial incentives, and educational resource were additional important elements of the intervention.
Le nu antique sur les sceaux du Moyen Âge : le remploi d’intailles (fin XIIe-milieu du XIVe siècle)
Authors: Simonet Caroline 
Published: June 2019

The classical nude on medieval seals : the reuse of intaglios (late 12th century to mid-14th century)
During the twelfth century, some matrixes for seals were set with antique intaglios or cameos with nude figures. This practice was not restricted to the elite, but touched a broad spectrum of society until the mid-fourteenth century, when it rapidly declined. The presence of female nudes has often been noted on clerical seals, although male nudes predominate on both lay and clerical matrixes. In most cases the degree of understanding of this iconography by medieval society cannot be determined. Some seals, however, reveal a deep knowledge of the classics. These seals were a sign of a high degree of culture that went beyond the religious and courtly dimension and encompassed Antiquity, obviously from the point of view and mentality of medieval taste and usage, but nonetheless quite distinct within contemporary production.