bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease
Authors: Qiu Chao , Xu Hui 
Published: December 2024

Background: Liquid-liquid phase separation (LLPS) has been increasingly recognized as a crucial mechanism in the pathogenesis of various neurodegenerative disorders, including Alzheimer's disease (AD). There remains a paucity of effective diagnostic biomarkers for this condition. This study aims to develop and validate a novel LLPS-related molecular signature to enhance the diagnostic accuracy and early detection of AD.
Methods: LLPS-related genes were identified from online databases and subjected to bioinformatic analyses, including protein-protein interaction (PPI) network analysis and least absolute shrinkage and selection operator (LASSO) regression. Based on the optimal LLPS-related genes, a diagnosis risk model was constructed, and the diagnostic ability was evaluated using a receiver operator characteristic (ROC) curve. To elucidate the biological functions of the identified LLPS-related genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted.
Results: A total of 149 LLPS-related genes were screened, which were found to be involved in functions related to oxidative stress, apoptosis, and cancer progression. The 149 genes were refined to six optimal candidates through PPI network analysis and LASSO regression: Activator of HSP90 ATPase Activity 1 (AHSA1), Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2 (EIF2AK2), Heat Shock Protein Family A (Hsp70) Member 4 (HSPA4), Notch Receptor 1 (NOTCH1), Superoxide Dismutase 1 (SOD1), and Thioredoxin (TXN). Based on the six optimal genes, a diagnostic risk model was constructed, and the diagnostic ability was verified to be promising in AD both in training, internal validation, and two external validation datasets, with area under ROC curve (AUC) above 0.8. Furthermore, significant correlations were observed between the expression of these genes and tumor immune cell infiltration.
Conclusions: A six-gene diagnosis model was constructed and verified to exhibit robust diagnostic ability in AD.
Factors Associated with Hospital Readmission in a Population with a Diagnosis of Personality Disorder
Authors: Carbonel-Aranda Vera , González Ariadna , García-Illanes Yaiza , Traverso-Rodríguez María , Bordallo-Aragón Antonio , Goodman-Casanova Jessica Marian , Guzman-Parra Jose 
Published: December 2024

Background: Hospital readmissions of users with personality disorders are frequent and represent a high personal and economic cost for health systems. This study aimed to identify risk factors associated with readmission in this population, examining sociodemographic and clinical variables.
Methods: A retrospective observational study was conducted, using electronic records. The study was carried out at the Mental Health Hospitalization Unit of the Regional University Hospital of Málaga, covering all admissions between January 1, 2007, and March 31, 2024. Patients with a primary or secondary International Classification of Diseases, 10th Edition (ICD-10) personality disorder diagnosis were included. The dependent variable was hospital readmission, analyzed both at 30 days and at 1 year. Mixed logistic regression models were used to identify risk factors.
Results: A total of 2403 admissions of 1072 individuals for 30-day readmission and 2256 admissions of 1029 individuals for 1-year readmission were analyzed; 17.15% of the admissions resulted in readmission at 30 days, and 42.33% at 1 year. The variables significantly associated with early readmission in the multivariate analysis were younger age (odds ratio (OR) = 0.973, p < 0.001), having a history of previous admissions (OR = 1.900, p < 0.001), and voluntary admission (OR = 1.348, p = 0.033). For readmission at 1 year, the significant variables included younger age (OR = 0.973, p < 0.001), history of previous admissions (OR = 1.956, p < 0.001), having another type of personality disorder diagnosis other than emotionally unstable personality disorder (OR = 0.654, p = 0.006), and comorbidity with affective (OR = 1.726, p = 0.025) and anxiety (OR = 1.915, p = 0.034) disorders compared to no comorbidity.
Conclusions: This study identified key risk factors for hospital readmission of individuals with personality disorders, including younger age, previous admissions, voluntary admission, specific personality disorder types, and comorbidity with affective and anxiety disorders. These findings underscore the need for future research to better understand the risk factors for readmission in this population.
The Relationship Between Level of Health Knowledge and use of Herbal Therapy for Hypertension Patients at Aldehia ( One-Sere, Casmuto, Suli-Ua) Suco Buruma, Posto Administrativo Baucau, Municipiu Baucau, Timor Leste
Authors: Novio De Almeida Pareira  , Christina Trisnawati Setiawan  , Maria Goreti Owa  , Carmelita Barros  , Yoseph Uliyanto  , Leny Blegur  
Published: December 2024

This study aims to analyse the relationship between the level of health knowledge and the use of herbal therapy in hypertensive patients in Aldehia (One-Sere, Casmuto, Suli-Ua), Suco Buruma, Posto Administrativo Baucau, Municipiu Baucau, Timor Leste in 2024. This study used a quantitative design with a cross-sectional approach. The study population consisted of hypertensive patients in Aldehia (One-Sere, Casmuto, Suli-Ua), Suco Buruma, Posto Administrativo Baucau, Municipiu Baucau, Timor Leste in 2024. The sample was selected by random sampling. Data were collected through a structured questionnaire with variables of health knowledge, use of herbal therapy, and other factors that influence the decision to use herbal therapy.65% of hypertensive patients have a low level of health knowledge and 67.5% do not use herbal therapy. There was a significant relationship between the level of health knowledge and the use of herbal therapy. Statistical tests showed that a better level of health knowledge tended to be associated with increased use of herbal therapy, with a significant p-value (p = 0.000), which suggests that health knowledge influences patients' decision to adopt herbal therapy. Education level was significantly associated with herbal therapy use (p = 0.015), where higher education level increased the likelihood of herbal therapy use (Exp(B) = 2.034). This study shows the importance of improving health knowledge and education in influencing the use of herbal therapy among hypertensive patients.
Технологии и технические средства АО «АРТ-ОСНАСТКА» для установки цементных мостов большой протяженности
Authors: И.Р. АСФАНДИЯРОВ , И.Р. АСФАНДИЯРОВ , Р.Р. СУЛЕЙМАНОВ , Ф.Ф. МИНГАЗОВ 
Published: December 2024

Основной тенденцией последних лет является оптимизация производственных процессов с целью сокращения затрат на строительство скважин. Достижение этих целей невозможно без непрерывной разработки новых технологий и технических средств, применяемых для решения данных задач. Долгие годы большая доля разработок по оптимизации процессов и усовершенствованию нефтегазового оборудования на российском нефтесервисном рынке была представлена западными поставщиками. После их ухода с рынка компания АО «АРТ-Оснастка» стала одним из лидеров по разработке новых технологий и изготовлению нестандартного оборудования для строительства нефтяных и газовых скважин.
Optimization of manufacturing processes to reduce well construction costs has been the main trend in recent years. It is impossible to achieve these goals without continuous development of new technologies and technical tools used to solve these tasks. For many years, a large share of developments in the sphere of process optimization and oil and gas equipment improvement at the Russian oilfield service market was represented by Western suppliers. After their exit from the market, ART-Osnastka became one of the leaders in development of new technologies and manufacturing of non-standard equipment for oil and gas well construction.
AVALIAÇÃO DA PRESENÇA DE LÍQUIDO AMINIÓTICO MECONIAL BASEADO EM FATORES MATERNOS E FETAIS DURANTE O PRÉ-NATAL E O PARTO
Authors: Simões Amabille Dellalibera , Machado Alvaro Nunes , Loureiro Liz Silva , Borges Gabriel Aparecido Cantalogo , Oliveira Gustavo Alves De , Tomich Michaela Franco , Rodrigues Iara Guimares 
Published: December 2024

O presente trabalho é resultado de um estudo observacional, transversal e retrospectivo com o objetivo de investigar a relação entre a presença LAM e diversos fatores maternos e fetais. A pesquisa foi conduzida no Hospital Municipal Modesto de Carvalho, em Itumbiara-GO, envolvendo uma amostra de 230 gestantes. Os dados coletados incluíram a presença ou ausência de LAM peso ao nascer, intercorrências durante a gestação e o nascimento, incluindo Apgar dos recém-nascidos. Para a análise estatística dos dados, foi utilizado o software JASP, realizando estudos descritivos e testes de associação, como o teste exato de Fisher. Os resultados obtidos revelaram uma associação significativa entre a presença de LAM e fatores como o tipo de parto e intercorrências durante o trabalho de parto. Observou-se que neonatos expostos a LAM apresentaram uma maior porcentagem de índices de Apgar inferiores a 7, indicando um potencial aumento no risco de asfixia fetal. Embora o índice de Apgar não tenha alcançado significância estatística, a tendência observada sugere que a presença de LAM pode estar relacionada a um estado de saúde comprometido dos RN. A conclusão do estudo enfatiza a importância de um pré-natal adequado e de um monitoramento contínuo do bem-estar fetal para prevenir complicações neonatais associadas ao LAM. Destaca-se que a identificação precoce de fatores de risco, e a implementação de práticas baseadas em evidências, como a monitorização eletrônica em tempo real, podem ser cruciais para melhorar os desfechos. Trata-se de um trabalho com limitações, como a falta de séries temporais nos dados e o desenho retrospectivo do estudo, que dificultam a avaliação de relações causais. Sugere-se que futuras pesquisas com um design prospectivo e multicêntrico sejam realizadas para aprofundar a compreensão das interações entre fatores obstétricos, neonatais e maternos na ocorrência de LAM, visando a aprimorar a qualidade da assistência ao binômio mãe-criança.
SEGURANÇA DO TRABALHO, EQUIPAMENTOS DE PROTEÇÃO INDIVIDUAL: ESTUDO DOS PREJUÍZOS CAUSADOS PELA NÃO UTILIZAÇÃO DOS EQUIPAMENTOS DE PROTEÇÃO INDIVIDUAL (EPI)
Authors: Santos Thiago Barbosa dos , Siqueira Ronaldo Alves de 
Published: December 2024

Este artigo aborda uma pesquisa bibliográfica referentes as medidas adotadas pelas empresas contra a resistência do uso dos EPIs, muitas empresas tem buscando ferramentas de conscientização para que seu colaboradores utilizem seus equipamentos de proteção individual(EPI), se forma segura e correta obedecendo as leis e normas estabelecidas pela legislação trabalhistas, analisando as reais condições de trabalho e cumprimento das normas e legislações vigentes, quanto ao uso de equipamentos de proteção individual, além dos motivos, sejam esses ergonômicos ou físicos, que levam os trabalhadores a optarem pelo não uso dos equipamentos de proteção individual durante a execução de suas atividades sem dúvidas nenhuma o uso dos equipamentos de proteção individual (EPI), é essencial para manutenção da saúde dos que fazem o uso de forma correta no exercício de suas variadas funções, colocando-se muitas vezes sob risco eminentes de acidentes, podendo assim ocasionar prejuízos a sua saúde física ou mental, o uso incorreto ou a não utilização poderá resultar em acidentes graves ou até mesmo fatais, trazendo desse modo consequências graves sejam econômicas ou social.

A partir de pesquisa relacionadas as segurança no trabalho percebemos a necessidade de realizar um estudo, para tentar identificamos os constantes problemas relacionados a saúde e segurança no trabalho e as constante s discursões em relação às regulamentações, e principalmente a preocupação com os direito do trabalhador que é preservação de sua própria vida, buscando ainda mais justifica esse estudo, procuramos identificar como estão sendo realizadas as ações preventivas em relação a segurança dos trabalhadores.
A Case Report : Recurrent Herpes Labialis In A 12 Year Old Boy
Authors: Putu Mahadevy Pradnyandhari Putri  , Ida Ayu Uttari Priyadarshini  , Putu Ayu Paramitha Saraswaty  
Published: December 2024

Introduction: Herpes labialis, commonly known as cold sores, is an infection predominantly caused by herpes simplex type 1 (HSV-1). Transmission of herpes labialis occurs through direct contact with active lesions or bodily fluids, including saliva, from infected individuals. Patients with herpes labialis often report prodromal symptoms before lesions appear, such as fever, fatigue, loss of appetite, and muscle aches. Localized symptoms, including pain, burning, or itching at the site of the impending eruption, are also common. This case report discusses a recurrent herpes labialis case at Wangaya Regional General Hospital, aiming to enhance understanding of the condition's presentation, management strategies to prevent recurrence, and measures to minimize transmission. Case Report : A 12-year-old boy was diagnosed with recurrent herpes labialis caused by an infection with herpes simplex virus type 1 (HSV-1). This diagnosis was based on the patient's medical history, which indicated prodromal symptoms and polymorphic lesions, as well as dermatological examination findings that showed herpetiform vesicles with crusting. The patient’s history of similar symptoms and the lesion’s localization to the vermillion border of the lips support the diagnosis of a recurrent infection. Herpes labialis is most commonly seen in children, particularly those under 19 years of age, which corresponds with the patient’s age. The primary risk factor is direct contact with an infected individual, which aligns with the patient's history of frequently sharing food and drinks with a friend who also exhibited similar symptoms. Additionally, the patient was known to share electronic cigarettes (vapes) with schoolmates. Recurrent herpes labialis can be triggered by various factors, including weakened immunity and UV exposure, both of which were present in this case. Conclusion: The main treatment provided for this patient was oral acyclovir. The use of acyclovir aims to reduce symptoms, accelerate healing, and lower the risk of infection transmission. Acyclovir works by inhibiting viral replication through the suppression of DNA polymerase, which reduces the amount of active virus and speeds up recovery. The dosage of acyclovir given to the patient was in accordance with recommended guidelines. Supportive diagnostic tests, such as serology or Tzanck smear, are recommended to confirm the diagnosis. However, in this case, the diagnosis was already established through medical history and physical examination. Given that this is a contagious disease, the patient was educated on measures to reduce the risk of transmission.
Una estrategia didáctica para el proceso de enseñanza-aprendizaje de los Números Complejos
Authors: Toapanta Bautista Raúl W. 
Published: December 2024

La presente investigación tiene como objetivo, elaborar una estrategia didáctica para fortalecer el proceso de enseñanza-aprendizaje de los Números Complejos, esto se justifica en base a una encuesta realizada a 30 estudiantes de la Unidad Educativa “Equinoccio San Antonio”, donde el 47,50% de los estudiantes atribuye tener complicaciones en la comprensión de los Números Complejos y al aplicar una evaluación diagnóstica a 36 estudiantes se tiene un bajo rendimiento académico. El diseño de esta investigación es descriptivo y pre-experimental, la estrategia didáctica se basa en un proceso estructurado en cuatro etapas clave: primero la exploración inicial que tiene como objetivo identificar y evaluar los conocimientos previos, segundo la planificación, es estructurar y organizar el contenido, tercero la fase de ejecución es donde se aplica la planificación mediante el uso de GeoGebra y cuarto es el control que permite evaluar el logro de los objetivos de aprendizaje.
Como resultados de la investigación de la estrategia didáctica propuesta permitió fortalecer, que los estudiantes del 3 BGU, mejoren significativamente la comprensión de los Números Complejos de 5,58 a 7,33 de promedio. En conclusión, la investigación demuestra que la estrategia didáctica propuesta mejora el proceso de enseñanza-aprendizaje de los Números Complejos.
Anxiety and Depression in Patients with Cancer. A Case Report
Authors: Ionuț Păduraru Marius , Vollmer Jan , Precupanu Diana , Ciubară Alexandru Bogdan , Hozan Calin Tudor , Firescu Dorel , Ciubară Anamaria 
Published: December 2024

<p>Depression is among the leading causes of disability worldwide, leading in some cases, to suicide and it is considered to be the disease of the millennium. Clinical depression is a common disease, and yet frequently overlooked, source of suffering among patients with cancer. Anterior studies indicate that the rate of depression in cancer patients is thought to be up to three times higher than in the general population. Depression decreases the quality of life, compromises the outcomes, and results in increase the rates of mortality from cancer.</p><p><strong>Clinical case: </strong>We identify a 50-year-old woman diagnosed with bilateral ovarian high-grade serous carcinoma. The imaging investigations revealed multiple metastases (cT3bN1bM1b – TNM classification). This stadium made the patient to be a candidate only for palliative chemotherapy. At first visit at the oncological specialist, the patient was worried about her health condition, but after discussing with the medical oncologist about the treatment and side effects of chemotherapy, the patient gained confidence. During a routine chemotherapy infusion, the patient reports some special side effects like increase feeling of “going through the motions” as if in a trance-like state, episodes of sudden tearfulness, and feeling like she is “out of control”.</p><p>After the finish of the chemotherapy infusion, at the interview, the patient reports feeling safe, denies any self-harm or self-injurious thoughts, denies use of illicit substances and alcohol. She says that the impact of hair loss is very depressive for her. In these conditions, the oncologist decide to discuss an initial treatment plan with her that includes individual counseling. Individual counseling helps the patient to complete her palliative therapies and increase her confident after the post-chemotherapy CT exam result. However, there is progression of her disease after 6 months. After this exam, she becomes despondent and is struggling to complete daily activities. She reports specific symptoms for depressive disorder: sleeping poorly and lacking appetite, and no longer enjoys spending time with her friends and family or pursuing her interests. She is preoccupied with death and has difficulty concentrating, but fortunately denies any suicidal ideation or death wishes.</p><p>It was started the second line chemotherapy protocol. At this time the patient shows abandonment behavior, autolytic thoughts and drug ingestion triggered by acute family conflict, requiring psychiatric re-assessment and specialist treatment.</p><p><strong>Conclusion:</strong> Depression remains an under-recognised comorbidity in cancer patients, with major implications on patient suffering, mortality and healthcare expenditure. Depression in cancer is markedly different from depression in healthy individuals, and involves a unique symptomatology.</p>
Principals’ Instructional Leadership in Teacher Professional Development and its Relationship with Students' State Examinations Performance in Bururi Province Schools, Burundi
Authors: Nzambimana Onésime , Itegi Dr. Florence M. , Okech Dr. Daniel Otieno 
Published: December 2024

Purpose: Students who sit for the state examinations in Bururi Province have recently posted unsatisfactory performance. This poor performance could potentially have a severe impact on the educational system and the subsequent transfer from secondary schools to higher education if it is not addressed. The goal of the current research was to explore the principals’ leadership in teacher professional development and its relationship with student’s performance in the state examinations in secondary schools in Bururi Province.
Methods: The transformational leadership theory served as the foundation for the present study. The research design for this study was the correlational research design. The target population was public secondary schools in Bururi province and the study involved principals, teachers, and the provincial directors of education. The researcher used a purposive sampling technique to select 11 boarding schools, all the principals, and the 6 provincial directors of education in the study while simple random sampling was adopted to identify teachers who participated in the study. Principals’ and teachers' questionnaires, as well as interview guides for directors of education in Bururi province, were utilized for collecting data. For quantitative data, Pearson Moment Correlation Coefficient was used to identify correlations between the independent and dependent variables in this study. Qualitative data from the interview was analysed thematically.
Results: The findings indicated that coordination of teacher professional development had a positive and significant relationship with student performance in the state examination.
Conclusion: The study recommends that principals should strengthen activities related to instructional leadership in coordination with teacher professional development.
Un nouveau regard sur l’École historique de Québec
Authors: Laperle Dominique 
Published: December 2024

Le livre de François-Olivier Dorais (2022) confronte l’objet culturellement construit qu’est l’École historique de l’Université Laval à l’objet concrètement restitué. Dorais démontre que l’École de Québec n’est pas une école de pensée, car elle ne présente pas un grand degré d’intégration intellectuelle de ses principaux représentants : Marcel Trudel, Jean Hamelin et Fernand Ouellet. Son héritage se présente surtout comme un projet historiographique et méthodologique d’histoire sociale et économique pratiquée dans un réseau de collaborations. Ce livre permet de réfléchir plus largement sur les controverses qui secouent la société, le monde de la recherche universitaire et le domaine de l’enseignement de l’histoire.
Medición de la vulnerabilidad financiera en organizaciones de la Economía Social y Solidaria: el caso de las universidades chilenas
Authors: Díaz Ramos Alejandro 
Published: December 2024

Mediante este estudio se han determinado cuantitativamente los niveles de vulnerabilidad financiera que caracterizan a las universidades que conforman el sistema de educación superior chileno. La motivación del estudio se encuentra en las implicancias sociales que conllevan tanto el deterioro financiero como el eventual cierre de las instituciones universitarias, fenómeno que ya ha causado la clausura de algunas entidades en Chile, teniendo como resultado un fuerte impacto en el bienestar tanto de estudiantes como académicos. El trabajo se basa en la aplicación del modelo propuesto por Trussel (2002), el cual se desarrolló a partir de una regresión con variable dependiente categórica tipo “Logit”, implementado sobre información financiera de entidades no lucrativas. Para los propósitos de esta investigación, el modelo de Trussel se aplicó sobre la información contenida en los estados financieros auditados anuales de las universidades chilenas reportada entre los años 2014 al 2021. Los resultados del estudio muestran que en general las universidades han mantenido su nivel de vulnerabilidad a lo largo del tiempo, esto a pesar de que el número de entidades vulnerables ha disminuido en el periodo analizado. Particularmente, se observa que a partir del año 2016 la mayoría de las entidades disminuye la probabilidad de enfrentar vulnerabilidades financieras, hecho que coincide con la implementación de la política pública relacionada con el sistema de acceso gratuito a la educación superior.