bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hunter‐gatherers as models in public health
Authors: Pontzer H. , Wood B. M. , Raichlen D. A. 
Published: December 2018

SummaryHunter‐gatherer populations are remarkable for their excellent metabolic and cardiovascular health and thus are often used as models in public health, in an effort to understand the root, evolutionary causes of non‐communicable diseases. Here, we review recent work on health, activity, energetics and diet among hunter‐gatherers and other small‐scale societies (e.g. subsistence farmers, horticulturalists and pastoralists), as well as recent fossil and archaeological discoveries, to provide a more comprehensive perspective on lifestyle and health in these populations. We supplement these analyses with new data from the Hadza, a hunter‐gatherer population in northern Tanzania. Longevity among small‐scale populations approaches that of industrialized populations, and metabolic and cardiovascular disease are rare. Obesity prevalence is very low (<5%), and mean body fat percentage is modest (women: 24–28%, men: 9–18%). Activity levels are high, exceeding 100 min d−1 of moderate and vigorous physical activity, but daily energy expenditures are similar to industrialized populations. Diets in hunter‐gatherer and other small‐scale societies tend to be less energy dense and richer in fibre and micronutrients than modern diets but are not invariably low carbohydrate as sometimes argued. A more integrative understanding of hunter‐gatherer health and lifestyle, including elements beyond diet and activity, will improve public health efforts in industrialized populations.
How much exercise should be promoted to raise total daily energy expenditure and improve health?
Authors: Byrne N. M. , Hills A. P. 
Published: December 2018

SummaryDespite longstanding recognition of the benefits of a physically active lifestyle, there remains ambiguity regarding exactly how much exercise should be promoted to raise total energy expenditure (TEE) and improve health. This review provides a brief summary of the dose–response relationship between physical activity and relative risk of morbidity and mortality; mechanisms through which exercise drives an increase in TEE; the highest reported levels of TEE measured via doubly labelled water; and the potential impact of non‐compliance and confounders in moderating the contribution of exercise to increase TEE. Cohort studies provide a compelling argument that ‘more is better’ regarding the exercise dose for increasing TEE, that increasing TEE is protective for health, and that this is mediated through increased cardiorespiratory fitness. However, growing evidence shows that ever increasing volumes of weekly physical activity may reverse the cost–benefit seen with more modest doses. Animal and human studies show that the elevation in TEE associated with increasing exercise volume is commonly less than expected, due to physiological confounders. Further, there is considerable evidence of behavioural non‐compliance to planned exercise in all but the most highly motivated athletes. Therefore, inbuilt defence mechanisms may safeguard against TEE being elevated to maximum levels.
Modulation of thermogenesis and metabolic health: a built environment perspective
Authors: van Marken Lichtenbelt W. D. , Pallubinsky H. , te Kulve M. 
Published: December 2018

SummaryLifestyle interventions, obviating the increasing prevalence of the metabolic syndrome, generally focus on nutrition and physical activity. Environmental factors are hardly covered. Because we spend on average more that 90% of our time indoors, it is, however, relevant to address these factors. In the built environment, the attention has been limited to the (assessment and optimization of) building performance and occupant thermal comfort for a long time. Only recently well‐being and health of building occupants are also considered to some extent, but actual metabolic health aspects are not generally covered. In this review, we draw attention to the potential of the commonly neglected lifestyle factor ‘indoor environment’. More specifically, we review current knowledge and the developments of new insights into the effects of ambient temperature, light and the interaction of the two on metabolic health. The literature shows that the effects of indoor environmental factors are important additional factors for a healthy lifestyle and have an impact on metabolic health.
Fatal septic cavernous sinus thrombosis following dental extraction: a case report
Authors: Almansoori Akram Abdo , Choung Han‐Wool , Kim Jo‐Eun , Kim Bongju , Kim Soung‐Min , Lee Jong‐Ho 
Published: December 2018

AbstractCavernous sinus thrombosis is a rare complication of odontogenic infection. A coexistence of compromised medical condition would reduce the patient survivability. In this context, we reported a 66‐year‐old female who developed an odontogenic infection and cavernous sinus thrombosis within 1 day after an upper tooth extraction. Considered as a life‐threatening complication status of odontogenic infection, the patient was referred to the emergency medicine department for intensive care with differential diagnosis of cavernous sinus thrombosis and masticator space infection. It was revealed that the patient had an uncontrolled diabetes mellitus and acute kidney injury. Later the patient developed a septic shock and died in almost 2 days since the tooth extraction. This makes it very important for the dentists to raise suspicion of uncontrolled status in those patients with history of diabetes mellitus and manage them carefully with proper antibiotic cover when undergoing dental procedures.
Gauging the Impact of Transparency Policies
Authors: Michener Gregory 
Published: December 2018

AbstractTo what extent do transparency policies generate positive impacts? This seemingly rhetorical question has become the subject of increasing contention, partly because of two research‐based biases. First, researchers have been blinded by metrics and method. Using tools that are often ill suited to gauging the gradual, diffuse, and indirect effects of most transparency policies, research has found—unsurprisingly—spotty evidence of impact. Transparency studies would benefit from greater use of complementary approaches, such as careful tracing of impact processes and indicators, combined with sensible counterfactual reasoning. Second, researchers have been looking for impact with blinkered vision. In particular, a thematic fixation on accountability and participation has monopolized attention. Key preconditions—such as compliance with and implementation of transparency policies—remain relatively neglected, as do other areas of potential impact, including capacity building, how actors are leveraging previously restricted streams of information, and transparency's role in improving policy coordination and communication.
Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression
Authors: Jama Abdulrahman , Huang Dengtong , Alshudukhi Abdullah A. , Chrast Roman , Ren Hongmei 
Published: December 2018

Key points
Lipin1 is critical for skeletal muscle development.
Lipin1 regulates MyoD and myocyte‐specific enhancer factor 2C (MEF2c) expression via the protein kinase C (PKC)/histone deacetylase 5‐mediated pathway.
Inhibition of PKCμ activity suppresses myoblast differentiation by inhibiting MyoD and MEF2c expression.
AbstractOur previous characterization of global lipin1‐deficient (fld) mice demonstrated that lipin1 played a novel role in skeletal muscle (SM) regeneration. The present study using cell type‐specific Myf5‐cre;Lipin1fl/fl conditional knockout mice (Lipin1Myf5cKO) shows that lipin1 is a major determinant of SM development. Lipin1 deficiency induced reduced muscle mass and myopathy. Our results from lipin1‐deficient myoblasts suggested that lipin1 regulates myoblast differentiation via the protein kinase Cμ (PKCμ)/histone deacetylase 5 (HDAC5)/myocyte‐specific enhancer factor 2C (MEF2c):MyoD‐mediated pathway. Lipin1 deficiency leads to the suppression of PKC isoform activities, as well as inhibition of the downstream target of PKCμ, class II deacetylase HDAC5 nuclear export, and, consequently, inhibition of MEF2c and MyoD expression in the SM of lipin1Myf5cKO mice. Restoration of diacylglycerol‐mediated signalling in lipin1 deficient myoblasts by phorbol 12‐myristate 13‐acetate transiently activated PKC and HDAC5, and upregulated MEF2c expression. Our findings provide insights into the signalling circuitry that regulates SM development, and have important implications for developing intervention aimed at treating muscular dystrophy.
Antibodies to myelin oligodendrocyte glycoprotein in chronic relapsing inflammatory optic neuropathy
Authors: Liu Hongjuan , Zhou Huanfen , Wang Junqing , Xu Quangang , Wei Shihui 
Published: December 2018

Background/aimsTo evaluate the status of myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) in chronic relapsing inflammatory optic neuropathy (CRION) and investigate its different clinical characteristics and prognosis.MethodsPatients diagnosed with CRION were recruited by the Neuro-ophthalmology Department of the Chinese People's Liberation Army General Hospital from December 2015 to April 2017. Based on antibody status, they were assigned to either the MOG-CRION or seronegative-CRION groups.ResultsA total of 33 patients (38 eyes) were assessed and divided into the following groups: 22 (66.7%) MOG-CRION and 11 (33.3%) seronegative-CRION. The ratio of female to male was 1:1, and 81.8% of total CRION patients were adults (≥18 years). A total of 29 eyes (76.3%) showed severe visual loss (<20/200) during the first optic neuritis episode, and 37 eyes (72.5%) demonstrated good visual recovery (>20/40) during the final follow-up. The mean onset age of MOG-CRION patients was 28 ± 16 years (range 6–62), which was significantly younger than that of seronegative-CRION (45 ± 12 years, range 22–59) (p=0.029). The intraorbital and canalicular segments were highly involved in the orbital MRI of CRION patients. During the final follow-up, MOG-CRION patients had more bilateral involvement (p=0.008) and higher annualised relapse rates compared with the seronegative-CRION patients (p=0.019).ConclusionCRION was predominantly found in adults with unilateral ON and exhibited a higher rate of seropositive MOG-IgG. MOG-CRION, which may be a disparate subtype of MOG-IgG-induced demyelinating disease that needs further investigation, was found in younger patients at onset, with more bilateral involvement and more relapse tendency.
Intestinal failure after necrotising enterocolitis: incidence and risk factors in a Swedish population-based longitudinal study
Authors: Sjoberg Bexelius Tomas , Ahle Margareta , Elfvin Anders , Björling Oscar , Ludvigsson Jonas F , Andersson Roland E 
Published: December 2018

Background and objectivePaediatric intestinal failure (IF) is a disease entity characterised by gut insufficiency often related to short bowel syndrome. It is commonly caused by surgical removal of a large section of the small intestine in association with necrotising enterocolitis (NEC), which usually affects premature infants. This study investigated the incidence and risk of IF in preterm infants with or without NEC.DesignA matched cohort study to investigate the incidence and risk factors for IF in a population-based setting in Sweden from 1987 to 2009 using the Swedish Patient Register.ParticipantsInfants with a diagnosis of NEC (n=720) were matched for gestational age and year of birth with reference individuals without NEC (n=3656). The study cohort was censored at death, IF or at end of follow-up (2 years of age). We calculated HRs with 95%CIs for IF using Cox regression, adjusting for pertinent perinatal factors.ResultsIF was 15 times more common in the infants with NEC compared with the reference infants (HR=7.2, with 95% CI 3.7 to 14.0). Other risk factors for IF were small for gestational age, extreme preterm birth and abdominal surgery. Neonatal mortality in infants with NEC decreased from 20.6% in 1987–1993 to 10.4% in 2007–2009.ConclusionIF was more common in the infants with NEC but was also linked to extreme preterm birth, a history of abdominal surgery and small for gestational age. IF was more common at the end of the study period, indicating that it increases when more preterm infants with NEC survive the neonatal period.
The Kidney Supportive Care programme: characteristics of patients referred to a new model of care
Authors: Purtell Louise , Sowa P Marcin , Berquier Ilse , Scuderi Carla , Douglas Carol , Taylor Bernadette , Kramer Katrina , Hoy Wendy , Healy Helen , Bonner Ann 
Published: December 2018

ObjectivesFor many people with advanced kidney disease, their physical, psychological and emotional needs remain unmet. Kidney supportive care, fully integrating specialist kidney and palliative care teams, responds to the emotional and symptom distress in this cohort who may be on a non-dialysis care pathway or on dialysis and approaching end of life. We aimed to analyse and describe the operation and patient characteristics of a new kidney supportive care programme (KSCp).MethodsA multidisciplinary KSCp was introduced through a tertiary hospital in Brisbane, Australia. Operational information and characteristics of referred patients were collected from internal databases and electronic medical records and analysed descriptively. Patient data were collected using validated instruments to assess symptom burden, health-related quality of life, health state, functional status and performance at clinic entry and analysed descriptively.Results129 people with advanced kidney disease were referred to the KSCp within the first year (median age 74 (range 27.7–90.5), 48.1% female, median Charlson Comorbidity Index score 7 (IQR 6–8) and mean Integrated Palliative care Outcome Scale Renal score 19.6±9.8). 59% were currently receiving dialysis. The leading reason for referral was symptom management (37%). While quality of life and health state varied considerably among the cohort, in general, these parameters were well below population norms.ConclusionsResults indicate that patients referred to the KSCp were those with a strong need for a patient-centred, integrated model of care. Shifting focus to co-ordinated, multidisciplinary care rather than discrete specialty silos appears key to addressing the challenging clinical problems in end-of-life care.
Estimating drowning mortality in Tanzania: a systematic review and meta-analysis of existing data sources
Authors: Sarrassat Sophie , Mrema Sigilbert , Tani Kassimu , Mecrow Thomas , Ryan Dan , Cousens Simon 
Published: December 2018

BackgroundThe WHO advocates a 7-step process to enable countries to develop and implement drowning prevention strategies. We sought to assess, using existing data sources, the drowning situation in Tanzania as a first step in this process.MethodsWe searched for data on causes of death in Tanzania by reviewing existing literature and global datasets and by in-country networking. Authors and institutions were then contacted to request aggregate data on drowning mortality. Site-specific drowning estimates were combined using a random effects meta-analytic approach. We also tested for evidence of variations in drowning estimates by sex and by age group.ResultsWe acquired partial or complete information on drowning deaths for 13 data sources. We found strong evidence for substantial variations between study sites (p<0.001). Combining population-based data, we estimated an average of 5.1 drowning deaths per 100 000 persons per year (95% CI 3.8 to 6.3). The proportions of deaths due to drowning were 0.72% (95% CI 0.55 to 0.88) and 0.94% (95% CI 0.09 to 1.78) combining population-based data and hospital-based data, respectively. Males were at greater risk than females, while both under-five children and adults aged 45 years or more were at greater risk than those aged 5–44 years.ConclusionOur estimates of drowning burden are broadly in line with the 2016 Global Burden of Disease and the 2015 WHO Global Health Estimates. While this exercise was useful in raising the burden of drowning in Tanzania with policy makers, planning drowning prevention strategies in this country will require a better understanding of which subpopulations are at high risk.
Kabuki syndrome: international consensus diagnostic criteria
Authors: Adam Margaret P , Banka Siddharth , Bjornsson Hans T , Bodamer Olaf , Chudley Albert E , Harris Jaqueline , Kawame Hiroshi , Lanpher Brendan C , Lindsley Andrew W , Merla Giuseppe , Miyake Noriko , Okamoto Nobuhiko , Stumpel Constanze T , Niikawa Norio 
Published: December 2018

BackgroundKabuki syndrome (KS) is a clinically recognisable syndrome in which 70% of patients have a pathogenic variant in KMT2D or KDM6A. Understanding the function of these genes opens the door to targeted therapies. The purpose of this report is to propose diagnostic criteria for KS, particularly when molecular genetic testing is equivocal.MethodsAn international group of experts created consensus diagnostic criteria for KS. Systematic PubMed searches returned 70 peer-reviewed publications in which at least one individual with molecularly confirmed KS was reported. The clinical features of individuals with known mutations were reviewed.ResultsThe authors propose that a definitive diagnosis can be made in an individual of any age with a history of infantile hypotonia, developmental delay and/or intellectual disability, and one or both of the following major criteria: (1) a pathogenic or likely pathogenic variant in KMT2D or KDM6A; and (2) typical dysmorphic features (defined below) at some point of life. Typical dysmorphic features include long palpebral fissures with eversion of the lateral third of the lower eyelid and two or more of the following: (1) arched and broad eyebrows with the lateral third displaying notching or sparseness; (2) short columella with depressed nasal tip; (3) large, prominent or cupped ears; and (4) persistent fingertip pads. Further criteria for a probable and possible diagnosis, including a table of suggestive clinical features, are presented.ConclusionAs targeted therapies for KS are being developed, it is important to be able to make the correct diagnosis, either with or without molecular genetic confirmation.
Delayed parent artery occlusions following use of SILK flow diverters for treatment of intracranial aneurysms
Authors: Macdonald Ian R , Shankar Jai J S 
Published: December 2018

BackgroundThe efficacy of SILK flow diverters (SFD) in the management of cerebral aneurysms has been established. However, the risk of complications with parent artery occlusion (PAO) remains to be fully elucidated. The purpose of our study was to analyze intracranial aneurysms treated with SFDs and assess for occurrences and potential risk factors for PAO.Materials and methodsBetween September 2010 and September 2017, 34 patients were treated for intracranial aneurysms using SFDs at a Canadian institution. This database was retrospectively analyzed for frequency of PAOs and statistical analysis performed for potential contributing factors.ResultsFollowing treatment with SFDs, average clinical and imaging follow-ups were 31 and 22 months, respectively. PAOs were identified in 21% (7/34) of patients and occurred between 8 days and 1.5 years from intervention but only in 11.8% in those compliant to anti-platelet medications. These were all associated with anterior circulation aneurysms (P=0.131) and had no associated neurological deficits. Of these, 57% (4/7) had a fusiform morphology compared with only 19% (5/27) in non-occluded patients (P=0.039). The presence of clinical symptoms at the time of initial SFD intervention was significantly associated with PAO (P=0.021).ConclusionDelayed PAO is not an uncommon outcome of flow diverter deployment and could be seen up to 1.5 years after treatment with no associated neurological deficits. Anti-platelet non-adherence remains a risk factor for PAO. Fusiform morphology of the aneurysm and symptoms at the time of intervention were associated with subsequent occlusion.
Heartbeat scheduling: provable efficiency for nested parallelism
Authors: Acar Umut A. , Charguéraud Arthur , Guatto Adrien , Rainey Mike , Sieczkowski Filip 
Published: December 2018

A classic problem in parallel computing is to take a high-level parallel program written, for example, in nested-parallel style with fork-join constructs and run it efficiently on a real machine. The problem could be considered solved in theory, but not in practice, because the overheads of creating and managing parallel threads can overwhelm their benefits. Developing efficient parallel codes therefore usually requires extensive tuning and optimizations to reduce parallelism just to a point where the overheads become acceptable.
In this paper, we present a scheduling technique that delivers provably efficient results for arbitrary nested-parallel programs, without the tuning needed for controlling parallelism overheads. The basic idea behind our technique is to create threads only at a beat (which we refer to as the "heartbeat") and make sure to do useful work in between. We specify our heartbeat scheduler using an abstract-machine semantics and provide mechanized proofs that the scheduler guarantees low overheads for all nested parallel programs. We present a prototype C++ implementation and an evaluation that shows that Heartbeat competes well with manually optimized Cilk Plus codes, without requiring manual tuning.
Inferring crypto API rules from code changes
Authors: Paletov Rumen , Tsankov Petar , Raychev Veselin , Vechev Martin 
Published: December 2018

Creating and maintaining an up-to-date set of security rules that match misuses of crypto APIs is challenging, as crypto APIs constantly evolve over time with new cryptographic primitives and settings, making existing ones obsolete.
To address this challenge, we present a new approach to extract security fixes from thousands of code changes. Our approach consists of: (i) identifying code changes, which often capture security fixes, (ii) an abstraction that filters irrelevant code changes (such as refactorings), and (iii) a clustering analysis that reveals commonalities between semantic code changes and helps in eliciting security rules.
We applied our approach to the Java Crypto API and showed that it is effective: (i) our abstraction effectively filters non-semantic code changes (over 99% of all changes) without removing security fixes, and (ii) over 80% of the code changes are security fixes identifying security rules. Based on our results, we identified 13 rules, including new ones not supported by existing security checkers.