bluuebunny/crossref_metadata_2025_split huggingface dataset:
Valued outcomes in the cancer experience: Patient priorities and control.
Authors: Zaleta Alexandra Katherine , McManus Shauna , Miller Melissa F , Yuen Eva , Stein Kevin , Hurley Karen , Shockney Lillie D. , Goldberger Sara , Golant Mitch , Buzaglo Joanne S. 
Published: September 2018

84 Background: In the era of value-based cancer care, identifying what is important to cancer survivors, and their perceived control over these experiences, can inform shared decision-making and support quality care. We examined cancer patient priorities and control to guide the development of a new measure of patient value, Valued Outcomes in the Cancer Experience (VOICE). Methods: 459 cancer patients completed an online survey and rated level of importance and control over 54 value items (0 = not at all; 4 = very much). Items of most and least importance, items with most and least control, and rating discrepancies (importance-control) were identified. Bivariate associations with socio-demographics were examined. Results: Participants were 86% non-Hispanic White; mean age = 60 years, SD= 10; 38% breast cancer, 18% blood, 9% lung, 9% prostate; mean time since diagnosis = 6.5 years, SD= 6; 22% metastatic. Items of highest importance (quite a bit to very much) included, “Having your health care team (HCT) talk to you in a way that makes sense to you” (99% of participants); “Making decisions for yourself” (99%); “Talking honestly with your HCT about your illness” (99%). Participants reported the most control over, “Talking honestly with your HCT about your illness” (89%); “Making decisions for yourself” (88%), “Understanding your illness” (84%). Greatest discrepancies were, “Having your illness not get worse or come back” (96% Important; 27% Control); “Having energy to do things that are important to you (98% Important; 41% Control); “Being able to afford medical expenses” (96% Important; 49% Control); “Having a death free from suffering” (91% Important; 40% Control); “Having your medical providers communicate with each other about your care” (94% Important; 44% Control). Greater importance/control discrepancies were associated with lower income, unemployment due to disability, and poorer health ( ps < .05). Conclusions: Cancer patients experience notable discrepancies between personal priorities and their ability to control these experiences, suggesting key areas for intervention and support. Next steps include psychometric assessment to refine the VOICE scale to guide clinical and research efforts to improve patient care outcomes.
Understanding the value of clinical survivorship programs.
Authors: Gilmore Katherine Ramsey , Palos Guadalupe R. , Chapman Patricia , Lewis-Patterson Paula A. , Rodriguez Maria Alma 
Published: September 2018

86 Background: Various models of care exist for the growing number of cancer survivors; yet little is known about the value or the difference in the models’ costs. We sought to assess the professional billing and reimbursements of 2 models of survivorship care; a) oncologist-led and b) advanced practice providers (APPs). Methods: Data were collected from 6 disease specific survivorship clinics, genitourinary, gynecology, head and neck, lymphoma, melanoma, and thyroid. Billing data was obtained to determine the professional billing and reimbursement amounts for these visits over one fiscal year. Comparisons were made between the APP and oncologists average salaries to determine costs per model. Clinic FTE salaries were based on the amount of time an APP devoted to a survivorship activities with 33% fringe benefits added to salaries. Oncologists’ salaries were based on the annual average faculty salary by department including fringe. Results: Billing data of 4,255 outpatient survivorship visits across the six clinics from 09/1/2016 - 8/31/2017 were abstracted. Table 1 summarizes the percentage (%) of professional reimbursement by model of care, oncologist versus APP and survivorship clinic. Conclusions: These data indicate that the advanced practice providers' model of survivorship care was financially more efficient than the oncologist model. Further research is warranted to compare the clinical effectiveness of these models and their impact on patients' outcomes related to their quality of life and satisfaction with care.[Table: see text]
Imaging progression-free survival: How much does it matter to patients?
Authors: O'Donnell Jennifer , Robinson Andrew George , Booth Christopher M. , Koven Rachel , Eisenhauer Elizabeth A. , Brundage Michael Donald 
Published: September 2018

99 Background: Progression-free survival (PFS) is often used as a clinical trials outcome for evaluating new therapies for solid tumors. While PFS is a validated surrogate for overall survival (OS) or quality of life (QOL) in some settings, it is increasingly used in contexts where surrogacy is not established. The end point is a composite of survival, symptomatic progression, and imaging-only progression. The intrinsic value of asymptomatic (imaging-only) progression from the patient perspective is not known. Methods: Patients with advanced metastatic cancer (lung, colorectal, or ovarian) who had completed at least 3 months of chemotherapy and were attending a routine ambulatory clinic were recruited and participated in a structured discrete choice trade-off exercise. The interview guide and visual aids were developed by a multidisciplinary team including patient representatives. Participants were provided with a hypothetical clinical scenario and associated treatment options. Treatment options presented had the same OS time but longer time to imaging progression and were associated with various levels of toxicity and treatment time. A sliding scale was used for duration of imaging-only PFS to determine each patient’s willingness to trade longer time for a given level of toxicity. Results: 20 (11M, 9F) patients participated in interviews (Nov 2017 - Jun 2018). Given the scenario 85% (n = 17) of patients chose treatment with less toxicity and treatment duration even if associated with a shorter imaging-only PFS. Two patients chose a trade-off for a more toxic treatment with an increase in imaging PFS by 18 months and 24 months respectively. One patient chose to always opt for most aggressive treatment irrespective of PFS benefit and toxicity. Conclusions: Patients with metastatic cancer currently being treated with palliative chemotherapy overwhelmingly considered imaging-only PFS to be of low value when it was associated with increased toxicity but not with longer OS. In situations where surrogacy for OS and QOL has not been established, endpoints that de-emphasise the importance of imaging are required.
Transmitting the Memory of a Medieval Heretic
Authors: Dubois Danielle C. 
Published: September 2018

AbstractModern scholars have assumed that after Marguerite Porete was condemned for heresy in 1310 she disappeared from the historical record. However, the discovery of references to Porete in François de Belleforest's Grandes annales (1579) and Henri de Sponde's Annales ecclesiastici (1641) overturns this narrative and shows that these historians were responsible for reintroducing her story to the French public. Porete offered a powerful symbol that bolstered their vision of religion and state history, a vision that emphasized the purity of the Gallican Church and the role of the state in preserving its integrity in the face of heresy. Their shaping of the memory of Porete as a heretical Beguine expands our knowledge of book history, early modern research practices, and the dissemination of historical knowledge.On a longtemps supposé qu'après sa condamnation pour hérésie en 1310, Marguerite Porete avait disparu de l'histoire. Cependant, la découverte de références à Porete dans les Grandes annales de François de Belleforest (1579) et les Annales ecclesiastici de Henri de Sponde (1641) dément cette hypothèse et montre que ces historiens ont réintroduit son histoire au public français. Marguerite Porete constituait un puissant symbole pour leur vision de l'histoire religieuse et étatique qui renforçait l'importance de la pureté de l'Eglise gallicane, ainsi que le rôle que devait assumer l'Etat pour maintenir l'intégrité de l'Eglise face aux hérésies. Leur façonnage de la mémoire de Porete en tant que béguine hérétique jette la lumière sur l'histoire du livre, les pratiques de recherche à l'époque de la Renaissance, ainsi que la diffusion de connaissances historiques.
A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis
Authors: Parafati Maddalena , Kirby R. Jason , Khorasanizadeh Sepideh , Rastinejad Fraydoon , Malany Siobhan 
Published: September 2018

ABSTRACT
Hepatic steatosis, a reversible state of metabolic dysregulation, can promote the onset of nonalcoholic steatohepatitis (NASH), and its transition is thought to be critical in disease evolution. The association between endoplasmic reticulum (ER) stress response and hepatocyte metabolism disorders prompted us to characterize ER stress-induced hepatic metabolic dysfunction in human induced pluripotent stem cell-derived hepatocytes (hiPSC-Hep), to explore regulatory pathways and validate a phenotypic in vitro model for progression of liver steatosis. We treated hiPSC-Hep with a ratio of unsaturated and saturated fatty acids in the presence of an inducer of ER stress to synergistically promote triglyceride accumulation and dysregulate lipid metabolism. We monitored lipid accumulation by high-content imaging and measured gene regulation by RNA sequencing and reverse transcription quantitative PCR analyses. Our results show that ER stress potentiated intracellular lipid accumulation by 5-fold in hiPSC-Hep in the absence of apoptosis. Transcriptome pathway analysis identified ER stress pathways as the most significantly dysregulated of all pathways affected. Obeticholic acid dose dependently inhibited lipid accumulation and modulated gene expression downstream of the farnesoid X receptor. We were able to identify modulation of hepatic markers and gene pathways known to be involved in steatosis and nonalcoholic fatty liver disease (NAFLD), in support of a hiPSC-Hep disease model that is relevant to clinical data for human NASH. Our results show that the model can serve as a translational discovery platform for the understanding of molecular pathways involved in NAFLD, and can facilitate the identification of novel therapeutic molecules based on high-throughput screening strategies.
Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates
Authors: Klymenko Yuliya , Wates Rebecca B. , Weiss-Bilka Holly , Lombard Rachel , Liu Yueying , Campbell Leigh , Kim Oleg , Wagner Diane , Ravosa Matthew J. , Stack M. Sharon 
Published: September 2018

ABSTRACT
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. EOC dissemination is predominantly via direct extension of cells and multicellular aggregates (MCAs) into the peritoneal cavity, which adhere to and induce retraction of peritoneal mesothelium and proliferate in the submesothelial matrix to generate metastatic lesions. Metastasis is facilitated by the accumulation of malignant ascites (500 ml to &gt;2 l), resulting in physical discomfort and abdominal distension, and leading to poor prognosis. Although intraperitoneal fluid pressure is normally subatmospheric, an average intraperitoneal pressure of 30 cmH2O (22.1 mmHg) has been reported in women with EOC. In this study, to enable experimental evaluation of the impact of high intraperitoneal pressure on EOC progression, two new in vitro model systems were developed. Initial experiments evaluated EOC MCAs in pressure vessels connected to an Instron to apply short-term compressive force. A Flexcell Compression Plus system was then used to enable longer-term compression of MCAs in custom-designed hydrogel carriers. Results show changes in the expression of genes related to epithelial-mesenchymal transition as well as altered dispersal of compressed MCAs on collagen gels. These new model systems have utility for future analyses of compression-induced mechanotransduction and the resulting impact on cellular responses related to intraperitoneal metastatic dissemination.
This article has an associated First Person interview with the first authors of the paper.
A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Authors: Askeland Georgina , Rodinova Marie , Štufková Hana , Dosoudilova Zaneta , Baxa Monika , Smatlikova Petra , Bohuslavova Bozena , Klempir Jiri , Nguyen The Duong , Kuśnierczyk Anna , Bjørås Magnar , Klungland Arne , Hansikova Hana , Ellederova Zdenka , Eide Lars 
Published: September 2018

ABSTRACT
Huntington's disease (HD) is a monogenic, progressive, neurodegenerative disorder with currently no available treatment. The Libechov transgenic minipig model for HD (TgHD) displays neuroanatomical similarities to humans and exhibits slow disease progression, and is therefore more powerful than available mouse models for the development of therapy. The phenotypic characterization of this model is still ongoing, and it is essential to validate biomarkers to monitor disease progression and intervention. In this study, the behavioral phenotype (cognitive, motor and behavior) of the TgHD model was assessed, along with biomarkers for mitochondrial capacity, oxidative stress, DNA integrity and DNA repair at different ages (24, 36 and 48 months), and compared with age-matched controls. The TgHD minipigs showed progressive accumulation of the mutant huntingtin (mHTT) fragment in brain tissue and exhibited locomotor functional decline at 48 months. Interestingly, this neuropathology progressed without any significant age-dependent changes in any of the other biomarkers assessed. Rather, we observed genotype-specific effects on mitochondrial DNA (mtDNA) damage, mtDNA copy number, 8-oxoguanine DNA glycosylase activity and global level of the epigenetic marker 5-methylcytosine that we believe is indicative of a metabolic alteration that manifests in progressive neuropathology. Peripheral blood mononuclear cells (PBMCs) were relatively spared in the TgHD minipig, probably due to the lack of detectable mHTT. Our data demonstrate that neuropathology in the TgHD model has an age of onset of 48 months, and that oxidative damage and electron transport chain impairment represent later states of the disease that are not optimal for assessing interventions.
This article has an associated First Person interview with the first author of the paper.
Mesoporous Metal Catalysts Templated on Clay Nanotubes
Authors: Glotov Aleksandr , Stavitskaya Anna , Chudakov Yaroslav , Ivanov Evgenii , Huang Wei , Vinokurov Vladimir , Zolotukhina Anna , Maximov Anton , Karakhanov Eduard , Lvov Yuri 
Published: September 2018

Abstract
Halloysite is a natural tubular aluminosilicate clay of ca. 50 nm diameter and 0.5–1.5 micrometers in length. The nanoarchitectural modification of halloysite inner/outer surfaces can be achieved through supramolecular and covalent interactions exploiting its different inside/outside chemistry (Al2O3/SiO2). The tubular morphology makes halloysite a prospective nanotemplate for core-shell structured mesoporous catalysts. Catalytic metals can be incorporated on the nanotubes’ outer surface or in the inner lumens with selective metal binding. 2–5 nm diameter Au, Ag, Pt, Pd, Co, Ru, Cu-Ni, Fe2O3, CoxBy, CdS, and CdxZn1−xS particles were templated on halloysite. In this work, CdS and Ru-containing halloysite based nanocatalysts were synthesized via modification with organic ligands and microwave-assisted wetness ion impregnation. The catalytic hydrogenation of benzene and its homologues as well as phenol was performed. The impacts of the core-shell architecture, the metal particle size and seeding density were optimized for high reaction efficiency. An efficient Co-halloysite catalyst was formed using azines as ligands, and it contained 16 wt. % of cobalt with hydrogen evolution rate of 3.0 L/min × g(cat). The mesocatalysts produced are based on a safe and cheap natural clay nanomaterial and may be scaled-up for industrial applications.
Synthesis and Photophysical and Electrochemical Properties of Structural Isomers of Pyrazine-Based D-π-A-π-D Fluorescent Dyes
Authors: Enoki Toshiaki , Ohshita Joji , Ooyama Yousuke 
Published: September 2018

Abstract
The structural isomers of D-π-A-π-D fluorescent dyes 2,5-PD and 2,6-PD which are substituted with two diphenylamine-thienylcarbazole moieties (electron-donating and π-conjugated unit) on 2,5- and 2,6-positions of a pyrazine ring (electron-withdrawing unit) have been developed. It was found that the structural isomers 2,5-PD and 2,6-PD show a significant solvatofluorochromism (λem = 513–614 and 480–588 nm for 2,5-PD and 2,6-PD, respectively). The photophysical and electrochemical measurements, and density functional theory calculations reveal that 2,5-substituted pyrazine dye 2,5-PD possesses stronger photoabsorption and fluorescence properties in a longer wavelength region and at a lower LUMO energy level, compared to the 2,6-substituted structural isomer 2,6-PD.
Nanoporous CeO2 Supports Prepared from Amorphous Alloys: Enhanced Catalytic Performance for Hydrogen Generation from Formic Acid
Authors: Nozaki Ai , Yamashita Ayane , Fujiwara Ryosuke , Ueda Chiyako , Yamamoto Hiroaki , Morishita Masao 
Published: September 2018

Abstract
Nanoporous CeO2 samples as supports were prepared by chemical dealloying Ce-Al amorphous alloy, followed by synthesis of Au-Pd/CeO2 catalysts. The synthesized Au-Pd/CeO2 catalysts showed higher catalytic activity for hydrogen generation from formic acid than catalysts using supports prepared from a crystalline alloy precursor.
ДИСКУРСИВНЫЕ РЕПРЕЗЕНТАЦИИ «ЦИФРОВОГО ПОКОЛЕНИЯ» И СМЕНА ПАРАДИГМЫ ОБРАЗОВАНИЯ
Authors: Sheypak Svetlana Alexandrovna 
Published: September 2018

В статье проводится анализ функционирования в современном российском образовательном дискурсе сформировавшейся в начале 2000-х гг. и ставшей устойчивой, несмотря на ее критику, тенденции описывать взаимоотношения субъектов образовательного процесса в терминах «цифрового поколения», «цифровых аборигенов» и «цифровых иммигрантов». Анализ репрезентаций «цифрового поколения» демонстрирует использование в риторике конфликта между учащимися и преподавателями постколониальных и маркетинговых дискурсивных практик. Показано, как эти репрезентации используются в образовательном дискурсе для обоснования смены парадигмы образования для «цифрового поколения». Однако сопоставление дискурсивных репрезентаций «цифрового поколения» с социальными практиками, в которых реализуется цифровая компетентность современных пользователей доказывает необоснованность этих репрезентаций и их негативное влияние на завышенную самооценку и невысокую мотивацию подростков при формировании цифровой компетентности. В заключении обосновывается необходимость разработки новой парадигмы образования в результате исследований, выявляющих реальный уровень цифровой компетентности учащихся и сопоставляющих его с академическими и профессиональными требованиями, предъявляемыми к развитию цифровой компетентности.Цель. В статье рассматривается обоснованность смены парадигмы образования на основе дискурсивных репрезентаций «цифрового поколения».Метод или методология проведения работы. Методы критического дискурс-анализа позволяют сопоставить дискурсивные репрезентации «цифрового поколения» в научном и медийном образовательном дискурсе и социальные практики, выявленные в результате эмпирических исследований, посвященных описанию цифровой компетентности современных интернет-пользователей. По ключевым словам «аборигены», «иммигранты», «цифровое поколение» были отобраны для анализа репрезентации отношений учащихся и преподавателей, воспроизводящиеся в 2014–2017 гг. в медийном и научном дискурсах.Результаты. Выявлены противоречия между репрезентациями «цифрового поколения» в научных и медийных дискурсивных практиках и реальным уровнем его цифровой компетентности.Область применения результатов. Результаты исследования обосновывают необходимость развития эмпирических и теоретических исследований социальных практик, в которых реализуется цифровая компетентность субъектов образовательного процесса, как основы для разработки новой парадигмы образования в условиях цифровой коммуникации.
Book Reviews
Authors: Garcia-Arcicollar Àfrica Bauzà , Lupton Katherine 
Published: September 2018

Abstract
Dwelling in the Age of Climate Change: The Ethics of Adaptation, Elaine Kelly (2018) Edinburgh: Edinburgh University Press, 224 pp., ISBN: 9781474422987, e-Book, £75.00
Marketing for Tourism, Hospitality and Events: A Global and Digital Approach, Simon Hudson and Louise Hudson (2017) London: Sage, 387 pp., ISBN: 978-1-4739-2664-6, p/bk, £44.99
Unnaturalness of Hajj narratives: We-narrative and narrating performative collective subjectivity
Authors: Chenganakkattil Muhamed Riyaz 
Published: September 2018

Abstract
This article explores the performative aspects of Hajj and resultant collective subjectivity. It is attempted to theorize the collective nature of Hajj and collective subjectivity in the narratives of Hajj performance looking at the narratives written on Hajj and its experiences by Hajjis. It investigates the use of we-narrative, mainly found in the narratives of Hajj, which is probably used to evoke the feeling of community and collectivity in the readers or in the writer-performer himself or herself. It is argued that collective subjectivity is constructed through the narratives to display the collective character of Hajj. This kind of narrative process is seldom considered to be a part of conventional narrative structures and here it is categorized under the rubric of ‘unnatural narrative’. The exclusive character of we-narrative, as in Hajj narratives, has been considered for further analysis and an attempt has been made to conceptualize ‘we-narrator’ and ‘we-narrator’ under pertinent philosophical questions of ‘intentionality’ and ‘collective action’ and it is further made complex by taking them up in the narratological discussion on how to narrate the collective actions and what kind of persons can be used to capture the essence of the performance of ritual, Hajj pilgrimage as in case of this article.
The Qur’ānic recitation traditions of the Tatars and Bashkirs in Russia: Evolution of style
Authors: Imamutdinova Zilia 
Published: September 2018

Abstract
This article for the first time discusses the evolution of the Russian Turkic (Tatar and Bashkir) Qur’ānic recitation tradition as an integral phenomenon and, in parallel, identifies the differences in these two ethno-regional forms, provides the historical context to enable an understanding of the nature of changes, describes its development stages and outlines the specifics of professional and non-professional forms of the Qur’ānic recitation by Tatars and Bashkirs in terms of ethnical background and relations with the classical Arabic tradition. It summarizes the unique facts found in historical and other scientific sources, field research materials (interviews, audio and video records) and the results of the author’s scientific research for more than 25 years. Music notation and computer graphs are used for illustrative purposes.