bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative cell salvage use reduces the rate of perioperative allogenic blood transfusion in patients undergoing periacetabular osteotomy
Authors: van der Merwe Michael , Lightfoot Nicholas J , Munro Jacob T , Boyle Matthew J 
Published: October 2019

AbstractBlood loss during periacetabular osteotomy (PAO) is variable, with losses ranging from 100 to 3900 ml in published series. Perioperative allogenic blood transfusion is frequently utilized although is associated with significant risk of morbidity. Cell salvage (CS) is a common blood conservation tool; however, evidence supporting its use with PAO is lacking. Our aim was to assess whether CS affects perioperative allogenic blood transfusion rate in patients undergoing PAO. The clinical records of 58 consecutive PAOs in 54 patients (median age 24.7 years, interquartile range 17.8–29.4 years) performed by a single surgeon between 1 January 2016 and 30 April 2018 were reviewed. Autologous blood pre-donation and surgical drains were not used. Due to variable technician availability, CS was intermittently used during the study period. PAOs were allocated into a CS group or no cell salvage group (NCS group), according to whether an intraoperative CS system was used. There was no significant difference in patient age, gender, body mass index, dysplasia severity, regional anesthetic technique, tranexamic acid administration, surgical duration or estimated blood loss (all P > 0.05) between the two groups. The CS group had a lower preoperative hemoglobin compared to the NCS group (median, 13.4 g/dl versus 14.4 g/dl, P = 0.006). The incidence of allogenic blood transfusion was significantly lower in the CS group compared to the NCS group (2.5% versus 33.3% patients transfused, P = 0.003). Multivariate modeling showed CS use to be protective against allogenic blood transfusion (P = 0.003), with an associated 80-fold reduction in the odds of transfusion (odds ratio, 0.01; 95th% CI, 0–0.57). To our knowledge, this is the first study to assess the effect of CS use on allogenic transfusion rate in patients undergoing PAO. Our results demonstrate CS to be a mandatory component of blood conservation for all patients undergoing PAO.
The Resilience Songwriting Program for Adolescent Bereavement: A Mixed Methods Exploratory Study
Authors: Myers-Coffman Katherine , Baker Felicity A , Daly Brian P , Palisano Robert , Bradt Joke 
Published: October 2019

Abstract
Music therapy research with youth who are grieving often reports on a combination of interventions, such as lyric analysis, improvisation, and/or songwriting. Unfortunately, the lack of theoretical transparency in how and why these interventions affect targeted outcomes limits interpretation and application of this important research. In this exploratory study, the authors evaluated the impact of an 8-session, theory-driven group songwriting program on protective factors in adolescent bereavement, and also sought to better understand adolescents' experiences of the program. Using a single-group, pretest-posttest convergent mixed methods design, participants were enrolled from three study sites and included 10 adolescents (five girls and five boys), ages 11–17 years, who self-identified as grieving a loss. Outcomes measured included grief, coping, emotional expression, self-esteem, and meaning making. Qualitative data were captured through in-session journaling and semi-structured interviews. There were no statistically significant improvements for grief, self-esteem, coping, and meaning making. Individual score trends suggested improvements in grief. The majority of the participants reported greater inhibition of emotional expression, and this was statistically significant. Thematic findings revealed that the program offered adolescents a sense of togetherness, a way to safely express grief-related emotions and experiences verbally and nonverbally, and opportunities for strengthening music and coping skills. These findings suggest that engaging in collaborative therapeutic songwriting with grieving peers may decrease levels of grief, enhance creative expression, and provide social support. More research is needed on measuring self-esteem, emotional expression, coping, and meaning making outcomes in ways that are meaningful to adolescents.
An ALMA survey of the SCUBA-2 Cosmology Legacy Survey UKIDSS/UDS field: high-resolution dust continuum morphologies and the link between sub-millimetre galaxies and spheroid formation
Authors: Gullberg B , Smail Ian , Swinbank A M , Dudzevičiūtė U , Stach S M , Thomson A P , Almaini O , Chen C C , Conselice C , Cooke E A , Farrah D , Ivison R J , Maltby D , Michałowski M J , Simpson J M , Scott D , Wardlow J L , Weiss A 
Published: October 2019

ABSTRACT
We present an analysis of the morphology and profiles of the dust continuum emission in 153 bright sub-millimetre galaxies (SMGs) detected with ALMA at signal-to-noise ratios of >8 in high-resolution 0.18 arcsec (∼1 kpc) 870 $\mu$m maps. We measure sizes, shapes, and light profiles for the rest-frame far-infrared emission from these luminous star-forming systems and derive a median effective radius (Re) of 0.10 ± 0.04 arcsec for our sample with a median flux of S870 = 5.6 ± 0.2 mJy. We find that the apparent axial ratio (b/a) distribution of the SMGs peaks at b/a ∼ 0.63 ± 0.02 and is best described by triaxial morphologies, while their emission profiles are best fitted by a Sérsic model with n ≃ 1.0 ± 0.1, similar to exponential discs. This combination of triaxiality and n ∼ 1 Sérsic index are characteristic of bars and we suggest that the bulk of the 870 $\mu$m dust continuum emission in the central ∼2 kpc of these galaxies arises from bar-like structures. As such we caution against using the orientation of shape of the bright dust continuum emission at $\eqsim$ resolution to assess either the orientation of any disc on the sky or tits inclination. By stacking our 870 $\mu$m maps we recover faint extended dust continuum emission on ∼4 kpc scales which contributes 13 ± 1 per cent of the total 870 $\mu$m emission. The scale of this extended emission is similar to that seen for the molecular gas and rest-frame optical light in these systems, suggesting that it represents an extended dust and gas disc at radii larger than the more active bar component. Including this component in our estimated size of the sources we derive a typical effective radius of ≃0.15 ± 0.05 arcsec or 1.2 ± 0.4 kpc. Our results suggest that kpc-scale bars are ubiquitous features of high star-formation rate systems at $z$ ≫ 1, while these systems also contain fainter and more extended gas and stellar envelopes. We suggest that these features, seen some 10–12 Gyr ago, represent the formation phase of the earliest galactic-scale components: stellar bulges.
Spin evolution and feedback of supermassive black holes in cosmological simulations
Authors: Bustamante Sebastian , Springel Volker 
Published: October 2019

ABSTRACT
It is well established that the properties of supermassive black holes (BHs) and their host galaxies are correlated through scaling relations. While hydrodynamical cosmological simulations have begun to account for the coevolution of BHs and galaxies, they typically have neglected the BH spin, even though it may play an important role in modulating the growth and feedback of BHs. Here we introduce a new sub-grid model for the BH spin evolution in the moving-mesh code arepo in order to improve the physical faithfulness of the BH modelling in galaxy formation simulations. We account for several different channels of spin evolution, in particular gas accretion through a Shakura–Sunyaev α-disc, chaotic accretion, and BH mergers. For BH feedback, we extend the IllustrisTNG model, which considers two different BH feedback modes, a thermal quasar mode for high accretion states and a kinetic mode for low Eddington ratios, with a self-consistent accounting of spin-dependent radiative efficiencies and thus feedback strength. We find that BHs with a mass $M_{\mbox{{bh}}}\lesssim 10^{8}\, {\rm M}_{\odot }$ reach high spin values as they typically evolve in the coherent gas accretion regime, in which consecutive accretion episodes are aligned. On the other hand, BHs with a mass $M_{\mbox{{bh}}}\gtrsim 10^{8}\, {\rm M}_{\odot }$ have lower spins as BH mergers become more frequent, and their accretion discs fragment due to self-gravity, inducing chaotic accretion. We also explore the hypothesis that the transition between the quasar and kinetic feedback modes is mediated by the accretion mode of the BH disc itself, i.e. the kinetic feedback mode is activated when the disc enters the self-gravity regime instead of by an ad hoc switch tied to the BH mass. We find excellent agreement between the galaxy and BH populations for this approach and the fiducial TNG model with no spin evolution. Furthermore, our new approach alleviates a tension in the galaxy morphology–colour relation of the original TNG model.
The VMC survey – XXXV. model fitting of LMC Cepheid light curves
Authors: Ragosta Fabio , Marconi Marcella , Molinaro Roberto , Ripepi Vincenzo , Cioni Maria Rosa L , Moretti Maria Ida , Groenewegen Martin A T , Choudhury Samyaday , de Grijs Richard , van Loon Jacco Th , Oliveira Joana M , Ivanov Valentin D , Gonzalez-Fernandez Carlos 
Published: October 2019

ABSTRACT
We present the results of the light curve model fitting technique applied to optical and near-infrared photometric data for a sample of 18 Classical Cepheids (11 fundamentals and 7 first overtones) in the Large Magellanic Cloud (LMC). We use optical photometry from the OGLE III data base and near-infrared photometry obtained by the European Southern Observatory public survey ‘VISTA near-infrared survey of the Magellanic Clouds system’. Iso-periodic non-linear convective model sequences have been computed for each selected Cepheid in order to reproduce the multifilter light-curve amplitudes and shape details. The inferred individual distances provide an intrinsic weighted mean value for the LMC distance modulus of μ0 = 18.56 mag with a standard deviation of 0.13 mag. We derive also the Period–Radius, the Period–Luminosity, and the Period–Wesenheit relations that are consistent with similar relations in the literature. The intrinsic masses and luminosities of the best-fitting models show that all the investigated pulsators are brighter than the predictions of the canonical evolutionary mass–luminosity relation, suggesting a significant efficiency of non-canonical phenomena, such as overshooting, mass-loss, and/or rotation.
Generative deep fields: arbitrarily sized, random synthetic astronomical images through deep learning
Authors: Smith Michael J , Geach James E 
Published: October 2019

ABSTRACT
Generative adversarial networks (GANs) are a class of artificial neural network that can produce realistic, but artificial, images that resemble those in a training set. In typical GAN architectures these images are small, but a variant known as Spatial GANs (SGANs) can generate arbitrarily large images, provided training images exhibit some level of periodicity. Deep extragalactic imaging surveys meet this criteria due to the cosmological tenet of isotropy. Here we train an SGAN to generate images resembling the iconic Hubble Space Telescope eXtreme Deep Field (XDF). We show that the properties of ‘galaxies’ in generated images have a high level of fidelity with galaxies in the real XDF in terms of abundance, morphology, magnitude distributions, and colours. As a demonstration we have generated a 7.6-billion pixel ‘generative deep field’ spanning 1.45 deg. The technique can be generalized to any appropriate imaging training set, offering a new purely data-driven approach for producing realistic mock surveys and synthetic data at scale, in astrophysics and beyond.
Life in the fast lane: a direct view of the dynamics, formation, and evolution of the Milky Way’s bar
Authors: Bovy Jo , Leung Henry W , Hunt Jason A S , Mackereth J Ted , García-Hernández Domingo A , Roman-Lopes Alexandre 
Published: October 2019

ABSTRACT
Studies of the ages, abundances, and motions of individual stars in the Milky Way provide one of the best ways to study the evolution of disc galaxies over cosmic time. The formation of the Milky Way’s barred inner region in particular is a crucial piece of the puzzle of disc galaxy evolution. Using data from APOGEE and Gaia, we present maps of the kinematics, elemental abundances, and age of the Milky Way bulge and disc that show the barred structure of the inner Milky Way in unprecedented detail. The kinematic maps allow a direct, purely kinematic determination of the bar’s pattern speed of $41\pm 3\, \mathrm{km\, s}^{-1}\, \mathrm{kpc}^{-1}$ and of its shape and radial profile. We find the bar’s age, metallicity, and abundance ratios to be the same as those of the oldest stars in the disc that are formed in its turbulent beginnings, while stars in the bulge outside of the bar are younger and more metal-rich. This implies that the bar likely formed ${\approx}8\, \mathrm{Gyr}$ ago, when the decrease in turbulence in the gas disc allowed a thin disc to form that quickly became bar-unstable. The bar’s formation therefore stands as a crucial epoch in the evolution of the Milky Way, a picture that is in line with the evolutionary path that emerges from observations of the gas kinematics in external disc galaxies over the last ${\approx}10\, \mathrm{Gyr}$.
A mechanically-engineered spray to increase brain penetration of chemotherapeutic nanoparticles in the treatment of high-grade gliomas
Authors: McCrorie Phoebe , Taresco Vincenco , Xu Zeyuan , Ritchie Alison , Clarke Phillip , Marlow Maria , Rahman Ruman 
Published: October 2019

Abstract
Design and implementation of innovative local drug delivery systems (DDS) may overcome current limitations in GBM treatment, such as the lack of therapeutic drug concentrations reaching residual GBM cells following surgery.
Here we describe a novel DDS which utilises a bespoke mechanically engineered spray device, designed for safe surgical use, to deliver a mucoadhesive hydrogel containing chemotherapeutic nanoparticles (NPs) into the tumour resection margins. The overall aim is to spray a NP and polymer solution onto the resection cavity and potentially increase penetration of anti-cancer drugs within the 2 cm reoccurrence zone beyond the infiltrative margin.
The mucoadhesive gel of choice, pectin, is currently used in other in vivo applications; however we have repurposed this for the brain. Pectin is biocompatible with GBM and human astrocyte cells in vitro and showed neither toxicity nor inflammation for up to 2 weeks upon orthotopic brain injection. Pectin is biodegradable in artificial CSF and is capable of being sprayed from the engineered device.
A panel of polymeric, oil-based and polymer-coated NPs have been developed and optimised to maximise drug encapsulation of etoposide and olaparib as proof-of-concept for combination drug delivery. Etoposide/olaparib was chosen due to cytotoxicity from 5 GBM cell lines, including primary lines isolated from the invasive tumour margin (Mean IC50 of 1.1 µM and 8.3 µM respectively). The optimal NP/drug formulation (based on drug encapsulation, spray capability and bio-adhesiveness) will ultimately be assessed for tolerability and efficacy using orthotopic allograft and xenograft high-grade glioma models.
Identifying the Zika Virus Target Cell in Malignant Glioma
Authors: Girdler Gemma , Gracia Tannia , Fountain Daniel , Fajardo Jr Ted , Finlay Jack , Hallou Clément , Pollard Steve , Sweeney Trevor , Gergely Fanni , Rowitch David , Bulstrode Harry 
Published: October 2019

Abstract
The Zika Virus epidemic of 2015–2016 was associated with striking failure of forebrain development in infants born to infected mothers, resulting in microcephaly. Studies from numerous labs subsequently confirmed a selective effect of the virus on neural stem cell survival, self-renewal and differentiation. The glioma stem cells which drive glioblastoma and other malignant gliomas depend on neural stem cell transcription programs, so that understanding Zika infection in these cells promises valuable insights into future therapy. We describe here:
1) Study of low passage patient-derived glioblastoma cell lines and normal neural stem cells (CRUK Glioma Cellular Genetics Resource) in adherent culture to address the influence of glioma subtype on infectability
2) Application of genetically modified mCherry reporter Zika Virus strains to address the Zika target cell in glioblastoma.
3) Development of a cerebral organoid model to interrogate the differential effects of the virus on tumour cells and surrounding normal brain.
4) Demonstration of Zika infection on primary patient derived tissue in slice culture format
Using these tools we find that Zika targets a common stem cell population across tumour subtypes and neural stem cell controls, and in embryonic and primary tumour explants, and that infection is influenced by activity of cholesterol biosynthesis pathways.
Using DWI-MRI parameters from multi- B values acquisition and a histogram approach for assessment of early therapeutic response in glioblastoma
Authors: Islam Shah , Morrison Melanie , Orton Matthew , Grech-Sollars Matthew , Waldman Adam 
Published: October 2019

Abstract
Early evaluation of therapeutic response of GBM on imaging is limited by poor biological specificity of clinical MRI. Clinical DWI-MRI models assume diffusion is mono-exponential when derived from only two B-values, although it has been proven diffusion is multiexponential. Purpose: To assess the utility of quantitative diffusion MRI derived from multi B-value acquisitions in the assessment of treatment response. Methods: 13 patients were enrolled into our multicentre study. Imaging was performed pre-RT and mid-RT using a multi B-value acquisition. Histograms within ROIs defined by abnormal FLAIR signal. Changes in histogram percentile profiles were evaluated across the two timepoints and compared with RANO assessment. Results: Following treatment, 5 patients had PD, 4 SD and 4 CR. Patients with PD showed a histogram shift to the left across all models, in keeping with increased cellularity. Parameters DDC and f are the most predictive of PD against RANO assessment, and appear superior to ADC. Reduction in 75th centile (f) and 95th centile (DDC) are the most sensitive histogram metrics for predicting early PD. Discussion: This is the first study to use histogram analysis as a marker of early treatment response in GBM. Results suggest association between early changes in specific diffusion components and subsequent treatment response. Spatially-independent diffusion parameter comparisons provide unbiased sampling of tumour heterogeneity. Conclusion: Our preliminary data suggest differential changes in diffusion parameters early in treatment, and provide proof of principle for multi B-value analysis and spatially-independent longitudinal assessment of diffusion imaging for therapeutic assessment in GBM.
Management Evaluation of Metastasis in the Brain (MEMBRAIN) – A UK & Ireland prospective, multicentre observational study
Authors: Jung Josephine , Tailor Jignesh , Dalton Emma , J Glancz Laurence , Roach Joy , Zakaria Rasheed , P Lammy Simon , Chari Aswin , P Budohoski Karol , J Livermore Laurent , Yu Kenny , D Jenkinson Michael , M Brennan Paul , Brazil Lucy , Bunce Catey , Ashkan Keyoumars , Vergani Francesco 
Published: October 2019

Abstract

Background
Over the recent years an increasing number of patients with brain metastasis are being referred to the neuro-oncology multi-disciplinary team (NMDT). Our aim was to determine if referrals of this group of patients to the NMDT in the UK & Ireland comply with NICE guidelines and to assess referral volume, quality of information provided and its impact on NMDT decision-making.

Methods
Prospective multicentre oberservational study including all adult patients referred with ≥1 cerebral metastasis. Data was collected in neurosurgical units from 11/2017 to 02/2018. Demographics, primary disease, Karnofsky performance status (KPS), imaging and treatment recommendation were entered into an online database.

Results
1049 patients were analysed from 24 neurosurgical units. Median age was 63[range 21–93] years with a median number of 3[range 1–17] referrals per NMDT. The most common primary malignancies were lung (36.5%, n=383), breast (18.5%, n=194) and melanoma (12.0%, n=126). 51.6% (n=541) of the referrals to the NMDT were within the NICE 2006 guidelines, and resulted in specialist intervention being offered in 68.8%. 41.2% (n=197) of patients being referred outside of the NICE 2006 guidelines were offered specialist treatment. NMDT decision-making was influenced by number of metastases, age, KPS, primary disease status and extent of extracranial disease (univariate logistic regression, p<0.0001) as well as metastasis location/histology (p<0.05).

Conclusions
This study confirmed a national change in culture of referral patterns. We identified a delay in NMDT decision-making in ~20%, contributing to increased NMDT workload. New stratification tools may be needed to reflect advancements in diagnostics and treatment modalities.
Chromatin remodelling to facilitate treatment resistance in glioblastoma
Authors: Bruns Alexander-F , Rippaus Nora , Droop Alastair , Al-Jabri Muna , Care Matthew , Jenkinson Michael , Brodbelt Andrew , Chakrabarty Aruna , Ismail Azzam , Short Susan , F Stead Lucy 
Published: October 2019

Abstract
Recent findings from our group, and the wider community, show that standard treatment does not impose an apparent bottleneck on the clonal evolution of adult glioblastoma (GBM), implying a lack of direct therapeutic opportunity. This does not negate the possibility that multiple treatment-resistance mechanisms co-exist in tumours, repeated across patients, making a combination of targeted therapies a potentially effective approach. We investigated whether treatment resistance may be driven by selection of cellular properties conferred above the level of the genome. Differential expression analysis was performed on 23 pairs of primary and recurrent tumours from patients who received standard treatment and had a local recurrence treated by surgery and second line chemotherapy. This revealed a treatment-induced shift in cell states linked to normal neurodevelopment. The latter is orchestrated by cascades of transcription factors. We, therefore, applied a bespoke gene set enrichment analysis to our paired expression data to investigate whether any factors were implicated in co-regulation of the genes that were altered through therapy. This identified a specific chromatin remodelling machinery, instrumental in normal neurogenesis. We validated our results in an independent cohort of 22 paired GBM samples. Our results suggest that the chromatin remodelling machinery is responsible for determining transcriptional hierarchies in GBM, shown elsewhere to have different treatment sensitivities such that their relative abundances are altered through treatment.