bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Phenotypic Diversity from Molecular and Genetic Data
Authors: Harel Tom , Peshes-Yaloz Naama , Bacharach Eran , Gat-Viks Irit 
Published: July 2019

AbstractUncovering relationships between molecular and phenotypic diversity presents a substantial challenge. Harel et al. devised InPhenotype, a computational approach that combines gene-expression and genotype data to predict quantitative traits. The key advance...Despite the importance of complex phenotypes, an in-depth understanding of the combined molecular and genetic effects on a phenotype has yet to be achieved. Here, we introduce InPhenotype, a novel computational approach for complex phenotype prediction, where gene-expression data and genotyping data are integrated to yield quantitative predictions of complex physiological traits. Unlike existing computational methods, InPhenotype makes it possible to model potential regulatory interactions between gene expression and genomic loci without compromising the continuous nature of the molecular data. We applied InPhenotype to synthetic data, exemplifying its utility for different data parameters, as well as its superiority compared to current methods in both prediction quality and the ability to detect regulatory interactions of genes and genomic loci. Finally, we show that InPhenotype can provide biological insights into both mouse and yeast datasets.
O NORMATIVISMO UNIFORME DE TUGENDHAT E O ELOGIO A ARISTÓTELES
Authors: Heck José N. 
Published: July 2019

A Doutrina do direito é um dos últimos trabalhos de Kant. Recomposto para uma nova editoração, o texto tem merecido a atenção de e teóricos do direito. A presente contribuição examina a repercussão da obra jurídica de Kant nos escritos recentes de Tugendhat, um dos críticos mais notórios do pensamento kantiano. O artigo privilegia asrelações entre direito e moral, procura dar uma feição mais nítida à chamada razão trivial, tendo em vista as clássicas objeções de Hegel à razão prática kantiana.
CRITIQUE OF PUBLIC REASON REVISITED: KANT AS ARBITER BETWEEN RAWLS AND HABERMAS
Authors: De Oliveira Nythamar Fernandes 
Published: July 2019

Trata-se de revisitar o debate Rawls-Habermas,em particular, o problema da autonomia política à luz da apropriação que estes autores nos oferecem do procedimentalismo kantiano.Tanto John Rawls quanto Jürgen Habermas, em suas respectivas concepções de "cultura política" e "esfera pública," partem de uma equivocada atribuição de um fundacionalismo moral em Kant ("fato da razão") de forma a preservar o princípio normativo de universalizabilidade capaz de assegurar a estabilidade de uma "sociedade bem ordenada" (Rawls) e balizar o procedimentalismo democrático enquanto alternativa para os modelos liberais e republicanos (Habermas).
Effect of Preheating Temperature on Synthesis of Pure BiFeO3 via Sol–Gel Method
Authors: Taha G. M. , Rashed M. N. , El-Sadek M. S. , Moghazy M. A. 
Published: July 2019

Abstract
BiFeO3 (BFO) nanopowder was synthesized in a pure form via a sol- gel method based on glycol gel reaction. Effect of drying and preheating temperature on preventing other phases was studied. Many parameters were studied as calcination temperature and time & stirring temperature as well. The prepared powder was characterized by X-Ray Diffraction of powder (XRD) and Transmission Electron Microscope (TEM). High pure BiFeO3 was obtained by preheated process at 400 °C for 0.5 h and calcination at 600 °C for 0.5 h without any impurities compared to dry at110 °C.
Демографический анализ онкологической заболеваемости и смертности на основе данных популяционных раковых регистров северо-запада России
Authors: Андреев Евгений Михайлович , Барчук Антон Алексеевич , Турсун-заде Рустам Тимурович , Мерабишвили Вахтанг Михайлович 
Published: July 2019

Реально действующий популяционный раковый регистр дает возможность расчета системы показателей, характеризующих уровень онкологической заболеваемости и смертности населения на обслуживаемой регистром территории в некоторый период времени. Данные показатели по своим свойствам сходны с показателями таблиц смертности и мало зависят от возрастного состава населения, а также, в некоторой мере, не зависят от онкологической заболеваемости и смертности в предшествующие годы.
К сожалению, объем анализа баз данных популяционных раковых регистров регионов России ограничен. Также неизвестна полнота учета заболеваемости и смертности заболевших.
В работе были проанализированы данные 5 регионов Северо-Западного Федерального округа РФ в период с начала 2002 г. по конец 2013 г. Статья построена как сравнение двух периодов 2002-2007 и 2008-2013 гг. Объектом анализа стали изменения в заболеваемости, смертности от злокачественных новообразований и смертности больных (летальности) среди наиболее распространенных локализаций. Наряду с табличными показателями, такими как общее число когда-либо заболевших, число умерших, средний возраст в момент заболевания, средняя продолжительность жизни больного и др. рассмотрены стандартизованные по возрасту коэффициенты заболеваемости и смертности. Но главная цель статьи – демонстрация эффективности предложенного метода анализа и всего диапазона аналитических возможностей, которые открывает анализ доступных данных популяционного ракового регистра в России.
Can serum homocysteine predict hypertensive disorders of pregnancy?: an evidence from a case control study in a North Indian tertiary health care institution
Authors: Pathania Kushla , Verma S. K. , Chamotra Shaina , Chaudhary Ankit 
Published: July 2019

Background: Hypertensive disorders of pregnancy are a major cause of both maternal and foetal morbidity and mortality. Although pregnancy induced hypertension (PIH) is still regarded as a disease of theories and unknown etiology, elevated homocysteine level has been hypothesized as a key risk factor. Abnormally raised homocysteine has been significantly associated with increased risk of PIH, abruption, intrauterine growth restriction, recurrent pregnancy loss, intrauterine death and prematurity.Methods: The present case control study was conducted among 180 pregnant women (90 cases and 90 controls) in Kamla Nehru State Hospital for Mother and Child, IGMC Shimla, Himachal Pradesh with an objective of ascertaining the role of homocysteine in pregnancy related hypertensive disorders. Socio-demographic, clinical, biochemical including homocysteine level, laboratory and ultrasonographic parameters of all the participants were documented.Results: The mean homocysteine level of cases (18.30±10.81) was significantly higher than the controls (8.70±2.64). About 62.2% cases had abnormally raised homocysteine level (>15 µmol/L), while only 1.1% controls had such level. The odds of a case having abnormally elevated homocysteine level were 146.6 (CI: 19.52-1101) times to that of controls. Eclamptics had the highest homocysteine level followed by preeclamptics and controls.Conclusions: The present study significantly associates the abnormally elevated homocysteine levels with pregnancy related hypertensive ailments and demands much needed robustly designed studies to further explore the phenomenon. A simple intervention like estimating the much neglected homocysteine levels prior to pregnancy can definitely aid in predicting and preventing perinatal outcomes.
Maternal mortality statistics and risk factors at a tertiary hospital in Makurdi, Nigeria
Authors: Hemabh-Hilekaan Samuel K. , O. Eka P. , T. Maanongun M. , E. Unazi U. 
Published: July 2019

Background: To determine the magnitude of maternal mortality and its major causes including the trend and social demographic factors associated with the problem in our environment.Methods: A retrospective institutional review of all the case notes of maternal mortality at the Benue State University Teaching Hospital, Makurdi over a six-year study period, from July, 2012 to June, 2018 were computed and analyzed.Results: A total of 2,442 deliveries took place within the period under review, out of which 2,325 were live births. Total maternal deaths were 26, giving a total maternal mortality ratio (MMR) of 1,118 deaths per 100, 000. The major causes of maternal mortality during this period were unsafe abortion and its complications, hypertensive diseases in pregnancy, puerperal sepsis and obstetric hemorrhage.Conclusions: Maternal mortality remains very high at our facility y, although with a declining trend. This may be a reflection of the situation in the general population. Increased coverage of the National Health Insurance Scheme, blood availability and utilization of antenatal services will further reduce maternal mortality in Nigeria.
Maternal and neonatal complications in macrosomic pregnancies
Authors: Basher Rehab Husain , Hussien Mohmed Soliman , Nessr Nuriya Baharie 
Published: July 2019

Background: Fetal macrosomia is a common problem in obstetrics which leads to morbidity and mortality to both mothers as well as to the new-born due to complications of fetal macrosomia like prolonged labour, operative delivery, postpartum haemorrhage, perineal trauma, shoulder dystocia, birth trauma, perinatal asphyxia and perinatal mortality. This prospective study was conducted on fetal macrosomia to help future identification of such pregnancies, anticipate complications and to plan proper management.Methods: Maternal, fetal and neonatal consequences of macrosomia with specific attention to etiology of macrosomia in 170 pregnant women having gestational age of 37 weeks or more and high risk of fetal macrosomia were studied. Clinical estimation of fetal body weight was done using Leopold’s maneuvers and patient then referred for ultrasonography. Data was collected about mode of delivery, nature and severity of birth trauma.Results: It was found that maternal age (51.76%), multiparity (61.76%), maternal diabetes (20.59 %) was signiﬁcantly associated with macrosomia. Total caesarean rate in macrosomia was 26.4%. We got only 8 cases of birth trauma out of 170 macrosomic births.Conclusions: Pregnancies complicated by fetal macrosomia can be best managed by giving a trial of labour for babies with fetal weight below 5000 gram. Post gestation, multiparity found to be main risk factor for macrosomia.
Assessment of maternal and perinatal outcome in cases of prolonged pregnancy in a tertiary healthcare institute: a cross sectional observational study
Authors: Ghumare Jitendra Pundlik , Bargaje Ganesh Mahadeo 
Published: July 2019

Background: Prolonged pregnancy has always been regarded as a high‑risk condition because perinatal morbidity and mortality is known to rise. The interest in postdatism (just beyond expected date of delivery) has been recent and the management is controversial, more so with the advent of sonography providing information about placental aging and amount of amniotic fluid. The aim of the present retrospective study was to analyze the outcome of pregnancies which crossed the expected date of delivery.Methods: The present study was a cross sectional observational study, conducted between April 2018 to September 2018, among 90 cases presented with post dated pregnancy under the department of obstetrics and gynecology, in a tertiary medical teaching institute in Maharashtra.Results: Maximum number of cases, i.e., 22.22% indications were meconium stained liquor with fetal distress, in 18.51% cases indications were failure of induction, in 22.22% indications were nonreactive NST, in 17.61% cases indications were CPD.Conclusions: It was concluded that prolonged pregnancy was associated with significant risk of perinatal complications such as fetal distress, meconium aspiration syndrome and IUGR.
Maternal periodontitis and its influence on duration of gestation and fetal birth weight
Authors: Munivenkatappa Swetha , Govindaraj Srinivas M. 
Published: July 2019

Background: There has been a lot of interest in knowing the effects of oral health on adverse pregnancy outcomes like preterm births and low birth weight. Studies have yielded contradicting results and there are lot of confounding issues that blur the picture. Aim of the study is to determine the prevalence of periodontitis is pregnant population and determine the effect of periodontitis on preterm births and low birth weight.Methods: This was a cross sectional study of singleton pregnant women attending ante-natal checkups with oral interview and clinical examination. Oral examination was done at the beginning of third trimester of pregnancy. They were followed up to delivery to note the duration of gestation, birth weight of babies.Results: The prevalence of periodontitis was 22% with 90.9% having mild and 9.1% having moderate periodontitis. Maternal education (high school and above) was associated with lower prevalence of periodontitis (p=0.042). There was no difference in the birth weights between the group with and without periodontitis (2.9±0.41kgs vs 2.74±0.36kgs, p=0.11). The incidence of low birth weights was also similar (p=0.22). The average gestational age was slightly less in the group with periodontitis (38 weeks 3 days vs 37 weeks 5 days) but the rates of preterm births were similar between the two groups (p=0.61).Conclusions: Mild/moderate periodontitis does not appear to have a significant effect on pre-term births and low birth weight. Maternal education and awareness seem to mitigate development of periodontitis and adverse pregnancy outcomes.
Congenital heart diseases and pregnancy, Universitary Hospital Center of Gynecology Obstetrical of Befelatanana, Madagascar
Authors: Razafindrainibe Tanjonirina , Rakotonomenjanahary Sidonie , Andrianirina Mamitiana , Ravel Nasolotsiry E. 
Published: July 2019

Background: Congenital heart diseases are malformations formed during the first weeks of life. Thanks to advances in medicine, they could be cared properly and pregnancies on heart diseases could be continued and completed. These malformations are sources of morbidity even high maternal fetal mortality. Whence our motivation to carry out this study and improve its care.Methods: This is a retrospective observational study reporting clinical cases of congenital heart disease pregnancies, only seen at the UHC-GOB over a seven years period (01 February 2007 - 28 February 2014).Results: We have identified 10 cases of congenital heart diseases out of 56 320 deliveries, that is, an incidence of 0.12 per 1000 deliveries. Isolated arterial canal persistence is predominant. The average age is 26±1. Four cases of congenital heart diseases diagnosed and repaired during childhood, have been noted as well as 02 cases of fortuitous discovery during pregnancy. No joint obstetric and cardiac follow up was performed for our patients. Delivery by high way is recommended in 70% of cases which 57% under peridural anesthesia. Half of the patients had peri-gestational cardiac decompensation such as dyspnea, pre-eclampsia and vacuo-shock progressively decreasing in post-partum. On the fetal side, we recorded 01 intra-uterine delayed growths, 03 premature births and 02 deaths.Conclusions: Pregnancy prognosis on congenital heart disease is based on the type of malformation, close follow up and a multidisciplinary care (Gyneco-obstetrician, Cardiologist, Reanimator, Pediatrician and Geneticist.
Child rearing practices in a rural community in Manipur: a cross-sectional study
Authors: Singh Haobam Danny , Keisam Avinash , Rajkumari Bishwalata 
Published: July 2019

Background: The child rearing practices differ in communities, depending on their social customs, traditional beliefs and prejudices. Understanding these practices is important for the successful delivery of health messages and services. The present study was conducted in a rural setting to determine the child rearing practices as well as to determine its association with relevant socio-demographic factors.Methods: This cross-sectional study was conducted among 369 mothers residing in Kshetrigao area under Kshetrigao Urban Health Centre, Porompat, Imphal East. A pre-tested interview schedule developed by the investigator was used for data collection. Descriptive statistics like mean, percentage and proportion as well as chi-square and t-test were used for data analysis.Results: Majority (79%) of the mothers breast-fed their newborn within 6 hours after birth. Almost half (46%) of the mothers gave pre-lacteal feeds to their newborn. Majority of the mothers (57%) did not practice exclusive breastfeeding. About 90% of the children were completely immunized for age. Mothers who got married before the age of 20 years, being Muslim and who had caesarean section were significantly less likely to practice exclusive breast feeding (p value of 0.025, 0.012 and 0.000 respectively). Children whose mother belongs to Muslim religion, lower educational status, lower family income and who delivered at home were significantly less likely to be completely immunized (p value of 0.001, 0.003, 0.014 and 0.003 respectively).Conclusions: Giving pre-lacteal feed and not practicing exclusive breast-feeding were very common among the studied population.
Assessment of immunization status among under five children in a census town of South India
Authors: Basti Bharatesh Devendra , Rajegowda Ravi Marinayakanahalli , Varaprasad Devi , Pitchandi Janakiraman 
Published: July 2019

Background: Deaths among children of less than five years are preventable, mostly by vaccination. In India, the coverage still remains low, as low as 44% children between 12 to 23 months age are fully immunized. This study was intended to assess the immunization status of the children between the age group of 12-60 months, and study the possible socio demographic factors influencing it.Methods: This cross-sectional study was conducted in 16 wards of a census town, selected by Multi-stage simple random sampling, for a period of 4 months among 400 children. Data was collected from the mothers of these children, using structured questionnaire.Results: Immunization status among these children showed that 32.5% were fully immunized, 52.0% were immunisation update, 14% were partially immunized, and 0.5% was not immunized. Immunization status was highest for BCG and OPV-0 (99%) and least for Measles 2nd dose and DPT booster (52%). Inadequate knowledge about immunization was the most common reason for partial and un-immunization. Multivariate Logistic regression analysis showed that, factors like religion (Hindus had 2.843 odds of being partially immunised than other religions), availability of Immunization card (Those without Immunisation card had 2.025 odds of being partially immunised than those with immunisation card) and place of immunization (Those immunised at private facilities had 1.441 odds of being partially immunised than those at government facilities), were found to be significantly associated with the immunization status of the child.Conclusions: Government facilities remain the main pillars of immunisation. Coordination with Anganwadi centres is the key. Tracking of the child for subsequent doses of immunisation remains a challenge.
Impact of Chhath festival on health seeking behaviour of local population
Authors: Pandey Avinash , Singh Anjana , Singh Shivkant , Kumar Amit , Shahi Heena , Kumari Aishwarya 
Published: July 2019

Background: There is lack of information regarding health seeking behaviour of local population during Chhath puja. The aim is to evaluate health seeking behaviour of local population during Chhath festival. And the main objectives is to evaluate the extent of change of routine visits of people seeking healthcare during Chhath festival across major super speciality departments of government hospital.Methods: Database of outpatient department visits across nine super specialities namely, cardiology, gastroenterology, gastrointestinal surgery, neurology, neurosurgery, nephrology, urology, paediatric surgery and oncology were obtained for year 2016, 2017 and 2018 from hospital records. Median and maximum number of outpatient visits per month of each of the nine specialities per year was compared with number of outpatient visits during Chhath festival month of corresponding year.Results: In year 2018, there was 18% average absolute decline of outpatient visit during Chhath month compared to median number of outpatient visits per month that year. Similarly, the average absolute decline of OPD visits was 32% during Chhath month compared to the month when there was maximum number of outpatient visits in 2018. Cardiology, gastroenterology, neurology, nephrology and oncology had more than 20% absolute decline in 2018 compared to median. Trends was similar in year 2017 and 2016, with average decline in Chhath month compared to median and maximum outpatient visits in corresponding year as 3%, 14%, 10% and 26% respectively.Conclusions: Health seeking behaviour of local population drops by one fifth during Chhath festival. Fall in outpatient visits is consistent, uniform and recurring every year.
Efficacy of cyclosporine 0.05% in patients with dry eye syndrome
Authors: Phogat Jitender , Verma Ritesh , Rathi Manisha , Sachdeva Sumit , Pandey Latika 
Published: July 2019

Background: An even and smooth ocular surface is vital for the functioning and comfort of the eyes. Dry eye is a group of disorders of the tear film which is due to either decreased production or increased evaporation and is associated with symptoms of ocular discomfort. Smoking and drugs have been suggested as risk factors in various studies. Cyclosporine has been shown to reduce the cell-mediated inflammatory reactions associated with the inflammatory ocular surface disease.Methods: 50 eyes of 25 patients suffering from dry-eye syndrome were included in this study. Three major ocular symptoms of dry eye i.e., ocular pain, burning, and foreign body sensation were studied in this study. Each symptom was given a score from 0 to 1 so that the ocular symptoms were given a score from 0 to 3.Results: There was a significant reduction in ocular symptoms score (OSS) 2.25 before treatment to 0.6 after 3 months of treatment (p=0.01). In addition, the Schirmer's paper test scores improved from 1.23 mm to 5.91 mm, which is significantly different (p=0.001). The tear film breakup time also improved from 5.49s to 9.86s.Conclusions: Cyclosporine 0.05% has been established to be effective and safe in our study.
Dietary practices in type 2 diabetes patients at Bhopal, Madhya Pradesh: a cross-sectional study
Authors: Lodha Rama Singodiya , Singh Smriti , Pal Dinesh Kumar , Toppo Manju , Verma Shipra , Jain Arpita , Nair Akhil R. 
Published: July 2019

Background: Diabetes mellitus (DM) is a rapidly growing health problem in India. Diet and physical activity are important modifiable risk factors affecting the incidence, severity and management of DM. The aim of the study was to assess diet of diabetes mellitus patients. 87 adults from a cohort of diabetic patients attending the Medical Clinics at the Hamidia Hospital Bhopal were invited for the study.Methods: Information about their nutritional status & food consumption pattern was taken by 24-hour dietary recall and food frequency questionnaire. Data was analysed using Epi Info and MS Excel. Frequency counts and percentages were used to describe the demographic characteristics of the participants while the significance difference in between male and female participants. The significance level was set at P <0.05 and 0.01. Statistical analysis used: MS Excel and Epi Info.Results: The study sample was 87 out of which 56 were females and 31 were males; mean age of DM patients was 48.21±12.98.The mean energy intake was 1386.52 kcal and 1125.79 kcal among male and female. The mean protein intake was 68.71 g and 50.50 among male and female diabetics. There was significant difference between male and female age. There were no significant difference in body mass index and waist hip ratio between male and female. 30 (34.5%) & 16 (18.4%) were overweight and obese respectively.Conclusions: Based on these findings, the dietary practices of diabetic patients are inadequate and require improvement. Education and counselling about diet of a diabetes patient is needed.