bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D-QSAR Assisted Design of Novel 7-Deazapurine Derivatives as TNNI3K Kinase Inhibitors Using Molecular Docking and Molecular Dynamics Simulation
Authors: Balasubramanian Pavithra K. , Balupuri Anand , Bhujbal Swapnil P. , Cho Seung Joo 
Published: January 2019

Background:Cardiac troponin I-interacting kinase (TNNI3K) is a cardiac-specific kinase that belongs to MAPKKK family. It is a dual-function kinase with tyrosine and serine/threonine kinase activity. Over-expression of TNNI3K results in various cardiovascular diseases such as cardiomyopathy, ischemia/reperfusion injury, heart failure, etc. Since, it is a cardiac-specific kinase and expressed only in heart tissue, it is an ideal molecular target to treat cardiac diseases. The main objective of the work is to study and understand the structure-activity relationship of the reported deazapurine derivatives and to use the 3D-QSAR and docking results to design potent and novel TNNI3K inhibitors of this series.Methods:In the present study, we have used molecular docking 3D QSAR, and molecular dynamics simulation to understand the structure-activity correlation of reported TNNI3K inhibitors and to design novel compounds of deazapurine derivatives with increased activity.Results:Both CoMFA (q2=0.669, NOC=5, r2=0.944) and CoMSIA (q2=0.783, NOC=5, r2=0.965) have resulted in satisfactory models. The models were validated using external test set, Leave-out- Five, bootstrapping, progressive scrambling, and rm2 metrics calculations. The validation procedures showed the developed models were robust and reliable. The docking results and the contour maps analysis helped in the better understanding of the structure-activity relationship.Conclusion:This is the first report on 3D-QSAR modeling studies of TNNI3K inhibitors. Both docking and MD results were consistent and showed good correlation with the previous experimental data. Based on the information obtained from contour maps, 31 novel TNNI3K inhibitors were designed. These designed compounds showed higher activity than the existing dataset compounds.
Adolescent Obesity and Eating Disorders: Can Calorie Restriction have a Positive Impact
Authors: Visweswaraiah Naveen , Nathan Kousalya 
Published: January 2019

Background:The current obesogenic environment with relatively increased affordability and availability of high calorie food and beverages, has led to an alarming increase in the prevalence of obesity and related lifestyle disorders in children and adolescents, predisposing them to accelerated aging. The increased prevalence may be due to the eating behavior of adolescents, their genetic and molecular etiology and/or due to the impact of psychological stress and their wrong lifestyle choices. Calorie restriction has been extensively researched for reducing the obesity in adolescents and adults but is yet to be successfully implemented.Objective:The present review paper focuses on the types of calorie restriction diets, the role of its mimics and the nutrigenomic mechanisms that may be helpful in reducing obesity and related disorders in the adolescents. The role of behavioral therapeutic techniques and physical activity has also been highlighted in addition to the calorie restricted diet for bringing about an overall lifestyle modification in the management of obesity.Conclusion:Food preferences are acquired in childhood and sound nutritional practices should be established in childhood to prevent lifestyle disorders and premature aging. Though CR is a known and preferred non-pharmacological intervention in the management of obesity, its implemention has not been explored and evaluated extensively. This is a vital area that needs scientific research as the goals of obesity managements are no longer just weight loss through dietary restrictions. An interdisciplinary method to lifestyle modification in the management of adolescent obesity addressing all physiological and psychosocial aspects is recommended.
Multilayer Neural Network with Synapse Based on Two Successive Memristors
Authors: Vo Minh-Huan 
Published: January 2019

Introduction:
Synapse based on two successive memristors builds the synaptic weights of the artificial neural network for training three-bit parity problem and five-character recognition.

Methods:
The proposed memristor synapse circuit creates positive weights in the range [0;1], and maps it to range [-1;1] to program both the positive and negative weights. The proposed scheme achieves the same accuracy rate as the conventional bridge synapse schemes which consist of four memristors.

Results and Conclusion:
However, proposed synapse circuit decreases 50% the number of memristors and 76.88% power consumption compared to the conventional bridge memristor synapse.
The Analysis of Dynamic O/D Adjustment for Bicycle Traffic Demand Estimation with AIMSUN Simulation Model: A Case Study of Nakhon Sawan Municipality in Thailand
Authors: Chalermwongphan Karn , Upala Prapatpong 
Published: January 2019

Aim:
This research aimed to present the process of estimating bicycle traffic demand in order to design bike routes that meet the daily transportation needs of the people in Nakhon Sawan Municipality.

Methods:
The primary and secondary traffic data were collected to develop a virtual traffic simulation model with the use of the AIMSUN simulation software. The model validation method was carried out to adjust the origin and destination survey data (O/D matrix) by running dynamic O/D adjustment. The 99 replication scenarios were statistically examined and assessed using the goodness-of-fit test. The 9 measures, which were examined, included: 1) Root Mean Square Error (RMSE), 2) Root Mean Square Percentage Error (RMSPE%), 3) Mean Absolute Deviation (MAD), 4) Mean Bias Error (MBE), 5) Mean Percentage Error (MPE%), 6) Mean Absolute Percentage Error (MAPE%), 7) Coefficient of Determination (R2), 8) GEH Statistic (GEH), and 9) Thiel’s U Statistic (Theil’s U).

Results:
The resulting statistical values were used to determine the acceptable ranges according to the acceptable indicators of each factor.

Conclusion:
It was found that there were only 8 scenarios that met the evaluation criteria. The selection and ranking process was consequently carried out using the multi-factor scoring method, which could eliminate errors that might arise from applying only one goodness-of-fit test measure.
"Inter-facing Reflexive Pedagogy"
Authors: Glen Carla Jane 
Published: January 2019

“Inter-facing Reflexive Pedagogy” is a chapter excerpt from my doctoral dissertation: Spectacle, Shock, and Surfacing (2009) that calls attention to visual culture through performative inquiry by making connections between meaning making for everyday life and the practice of installation art by repositioning one’s own body through the installation art form. This becomes meaningful for the spectator/participant by incorporating a reflexive encounter both historically with visual culture and socially where constructed techniques and procedures are closed to contextual circumstances. In a system of relations, through an engagement in counter-constructed spectacle strategies, learning involves the whole person; it implies becoming a full participant. Encounters with an art form are never just an end point, since it may challenge the spectator/participant to new encounters of experience. Merleau-Ponty links these encounters as a route —an experience that proceeds through dialogue and evokes change. By presenting moments of possibilities through physical, emotional, and intellectual spaces for discourse on subjects in and around visual culture, the spectator/participant has the opportunity to re-claim his or her agency and autonomy by first speaking through the installation and then to the
community of which he/she is a significant part.
Innovative aspects of I.P. Pavlov’s scientific and pedagogical activity
Authors: Chugunow Lena 
Published: January 2019

Formation and development of Pavlov’s scientific ideas are traced in the historical objective material of Pavlov’s school.
Ivan Petrovich Pavlov was a brilliant organizer of collective scientific work. His innovation was represented in famous «Pavlov’s Wednesdays», organized in 1922.
«Pavlov’s Wednesdays» is not only the document of the physiologist’s thinking process about the higher nervous system in its highest phase of development and informative complex of his scientific doctrine – it is a new method of scientific creativity – «collective thinking».
Effect of grafting on resistance to vine decline disease, yield and fruit quality in muskmelon cv. Sawadi
Authors: Al-Mawaali Qais , Al-Sadi Abdullah M , Al-Said Fahad A , Rahman Mohammed Shafiur , Al-Zakwani Intisar , Ali Amanat , Al-Yahyai M. , Deadman Michael L. 
Published: January 2019

A study was conducted to evaluate graft success, resistance to vine decline disease and effect of grafting on quality and yield of muskmelon. Two field experiments, conducted in Oman, showed that muskmelon cv. Sawadi grafted on six cucurbit rootstocks gave high grafting success: 97.6-99.1% (avg. 98.6%) and 92.4-96.9% (avg. 95.3%) under field conditions in fall 2012 and spring 2013 respectively. No significant differences were observed between seasons among the six treatments and a non-grafted control in consumer preference for odor and firmness, fruit shape, flesh vitamin C, micronutrient content and TSS (sucrose %) or pH in spring 2013 (P > 0.05). The concentration of phosphorus and sodium significantly decreased in both seasons in all treatments in comparison to the control (P > 0.05). In both seasons potassium content significantly increased when Rsscih7458 and Mubyeongjangsoo rootstocks were used (P < 0.05). Strong Tosa rootstocks showed zero graft failure, high resistance to vine decline disease, high yield production and higher TSS (sucrose %) as compared to other rootstocks. Strong Tosa and Tetsukabuto rootstocks showed significantly higher consumer acceptance for rind color, flesh color and overall consumer acceptance in spring 2013 and was also less affected by seasonal changes. Results suggested that by grafting muskmelon cv. Sawadi some quality attributes may be improved in addition to the increased level of resistance to disease. However, additional trials are required to make final recommendations for the farming community.
EKSISTENSI DISSENTING OPINION DALAM PUTUSAN PERKARA TINDAK PIDANA KORUPSI (Studi Putusan No : 20/Pid.Sus/2011/PN.Mks)
Authors: Herman Herman 
Published: January 2019

The existence of a dissenting opinion in the case investigation of corruption in terms of juridical reference to the Act No. 48 year 2009 on the judicial power. Based on the philosophical the existence of a dissenting opinion in a case of corruption as an extraordinary crime does not eliminate its essence as an extra crime. Application of the dissenting judges that occur analyzed show a dissenting judge believes the defendant is not an act of corruption but the crime of forgery under article 263, paragraph 1 of the Criminal Code and not the competence of the Corruption Court, Rather Competence General Court.Keywords: Dissenting Opinion, Corruption Decision Eksistensi dissenting opinion dalam pemeriksaan perkara tindak pidana korupsi dari segi yuridis mengacu pada Undang-Undang No. 48 Tahun 2009 tentang Kekuasaan Kehakiman. Secara filosofis eksistensi dissenting opinion dalam perkara tindak pidana korupsi sebagai kejahatan luar biasa tidak menghilangkan esensinya sebagai kejahatan extra. Penerapan dissenting opinion hakim yang terjadi dalam putusan yang dianalisis menunjukkan hakim yang dissenting opinion berpendapat perbuatan terdakwa bukan merupakan tindak pidana korupsi melainkan tindak pidana pemalsuan berdasarkan pasal 263 ayat 1 KUHP dan bukan merupakan kompetensi Pengadilan Tipikor melainkan Kompetensi Pengadilan Umum.Kata Kunci : Dissenting Opinion, Putusan Korupsi
URGENSI PENGELOLAAN ZAKAT TERHADAP PENINGKATAN PEREKONOMIAN MASYARAKAT
Authors: Mustarin Basyirah 
Published: January 2019

Amil zalcat institution as zakat managers acting as a bridge between Muzakki with Mustahik in collecting zakat funds, then manage and distribute the zakat funds properly and appropriately targeted to Asnaf recipients of zakat mentioned in Al-Quran. The management of zakat funds professionally conducted by zalcat amil as well as on the mustahiq side guarantees the proper delivery of the mandate, can also help to alleviate the community from the very urgent poverty problem today. Zakat funds used to empower the poor and needy will productively seek the transformation of mustahiq that has been memetaforsa into muzakki can help and more useful for other mustahiq. Keywords: Urgency, Management, Institute of amil zakat Lembaga amil zakat sebagai pengelola zakat yang bertindak sebagai jembatan penghubunga antara Muzakki dengan Mustahik dalam mengumpulkan dana zakat, kemudian mengelola serta mendistribusikan dana zakat tersebut secara benar dan tepat sasaran kepada para Asnaf penerima zakat yang telah disebutkan dalam Al-Quran. Pengelolaan dana zakat secara profesional yang dilakukan oleh lembaga amil zakat selain pada sisi mustahiq menjamin tersalurkannya amanah dengan tepat, juga dapat membantu mengentaskan masyarakat dari masalah kemiskinan yang amat urgen sekarang ini. Dana zakat yang dipergunakan memberdayakan kaum fakir dan miskin secara produktif akan mengupayakan terjadinya transformasi dari mustahiq yang telah bermetaforsa menjadi muzakki dapat membantu dan lebih bermanfaat lagi bagi para mustahiq lainnya.Kata kunci : Urgensi, Pengelolaan, Lembaga amil zakat
AKIBAT HUKUM KEPAILITAN PERSEROAN TERBATAS
Authors: Erlina Erlina 
Published: January 2019

Limited liability company declared bankrupt does not necessarily stop and disperse but still exist as legal entity. In certain circumstances still exist running its business as usual limited liability company does not happen bankruptcy and still able to do business activity. This is due to the company declared bankrupt have an economic value (economic value) is much higher than the value of the company's assets. Because the bankruptcy is actually destined for companies that have negative assets. Nevertheless, the decision to continue the bankruptcy company resulted in the power of the board of directors in a limited liability company. However, with the bankruptcy statement, the debtor by law lost the right to control and manage his property which was inserted into the bankruptcy property as of the date of the decision of bankruptcy.Keywords: Limited Liability Company, Bankruptcy, Receiver Perseroan terbatas yang dinyatakan pailit tidak serta merta berhenti dan bubar melainkan masih eksis sebagai badan hukum. Dalam keadaan tertentu masih eksis menjalankan usahanya seperti lazimnya perseroan terbatas tidak terjadi kepailitan dan tetap dapat melakukan kegiatan usahanya. Hal ini diakibatkan perseroan dinyatakan pailit mempunyai nilai ekonomis (economic value) yang jauh lebih tinggi dibanding nilai aset perusahaan tesebut. Oleh karena kepailitan sebenarnya diperuntukkan terhadap perusahaan yang mempunyai aset negatif. Namun demikian, keputusan untuk melanjutkan perseroan pailit mengakibatkan kekuasaan direksi dalam suatu perseroan terbatas.. Namun dengan adanya pernyataan pailit, debitor demi hukum kehilangan hak untuk menguasai dan mengurus harta kekayaannya yang dimasukkan ke dalam harta pailit terhitung sejak hari putusan pernyataan pailit tersebut.Kata kunci : Perseroan Terbatas, Kepailitan, Kurator
PENERAPAN AHLI WARIS PENGGANTI MENURUT KHI DAN KUHPERDATA DI KABUPATEN BONE (STUDI KASUS DI PENGADILAN AGAMA WATAMPONE
Authors: Bahtiar Suwardi 
Published: January 2019

AbstractEndowment system according to hukumadat in Sub-Province of Bone that is division of inappropriate heritage part of which its is it him accepted, in division of heritage finished upon mutual consensus without passing Justice of local Religion. Pursuant to Section 185 sentence (1), one can heir because replacement of place is one who is replaced by its child should have passed away in advance from heir and also one who is replaced by its child represent heir of andaikata he above the ground. Besides, top-drawer condition is that heir goodness which in fact and also substitution heir have to believe in Islam. Keyword : Heir Substitution AbstrakSistem pewarisan menurut hukumadat di Kabupaten Bone yaitu pembagian warisan tidak sesuai bagian yang semestinya diterima, dalam pembagian warisan diselesaikan secara musyawarah tanpa melalui Pengadilan Agama setempat. Berdasarkan Pasal 185 ayat (1), seseorang dapat mewaris karena penggantian tempat adalah orang yang digantikan oleh anaknya tersebut harus sudah meninggal dunia lebih dahulu dari pewaris serta orang yang digantikan oleh anaknya tersebut merupakan ahli waris andaikata ia masih hidup. Selain itu, syarat yang paling penting adalah bahwa baik pewaris yang sebenarnya maupun ahli waris pengganti harus beragama Islam.Kata Kunci : Ahli Waris Pengganti
PENERAPAN BEBAN PEMBUKTIAN TERBALIK DALAM UPAYA PENANGGULANGAN TINDAK PIDANA KORUPSI
Authors: Risal Muhammad Chaerul 
Published: January 2019

AbstractVerification burden in case of ordinary doing an injustice represent public procecutor duty. However, verification burden in natural corruption doing an injustice of change of new paradigm by applying inversion of verification burden. Through inversed verification of defendant should be able to prove that owned estae is it obtained by valid, but if defendant cannot prove that owned estae is it obtained by valid hence he earn to be considered to be perpetrator of corruption doing an injustice.Keyword : Urgency, Inversed Burden Verification, Doing An Injustice Corruption AbstrakBeban pembuktian dalam perkara tindak pidana biasa merupakan tugas jaksa penuntut umum. Akan tetapi, beban pembuktian dalam tindak pidana korupsi mengalami perubahan paradigma baru dengan menerapkan pembalikan beban pembuktian. Melalui pembuktian terbalik terdakwa harus bisa membuktikan bahwa harta yang dimilikinya diperoleh dengan cara yang sah, namun jika terdakwa tidak dapat membuktikan bahwa harta yang dimilikinya diperoleh dengan cara yang sah maka ia dapat dianggap sebagai pelaku tindak pidana korupsi.Kata Kunci : Urgensi, Beban Pembuktian Terbalik, Tindak Pidana Korupsi
PEMBUKTIAN DALAM TINDAK PIDANA LALU LINTAS
Authors: Amiruddin Muh. 
Published: January 2019

AbstractHeight mount accident of traffic ( lakalantas) alone if from lack of awareness of society in this case driver of motor vehicle with various coherent factor at x'self for example in the case of fitness of bodily, readiness of bouncing at the (time) of tired driver, influence of liquor, and forbidden. Condition of driver open big opportunity the happening of hard accident beside endanger safety of consumer of other roadway of Moo, sleepy, less skillful, fatigue, do not keep distance, accelerate untimely [is] example [of] mistake of driver in general. Keyword : Accident, Traffic, Liquor AbstrakTingginya tingkat kecelakaan lalu lintas (lakalantas) sendiri jika dari kurangnya kesadaran masyarakat dalam hal ini pengemudi kendaraan bermotor dengan berbagai faktor yang melekat pada dirinya misalnya dalam hal kebugaran jasmani, kesiapan mental pada saat pengemudi kelelahan, pengaruh minuman keras, dan obat-obatan terlarang. Kondisi ketidaksiapan pengemudi membuka peluang besar terjadinya kecelakaan yang parah disamping membahayakan keselamatan pengguna jalan raya lainnya Lengah, mengantuk, kurang terampil, lelah, tidak menjaga jarak, melaju terlalu cepat adalah contoh kesalahan pengemudi pada umumnya.Kata Kunci : Kecelakaan, Lalu Lintas, Minuman Keras
Tinjauan Terhadap Kesiapan Pustakawan dalam Menghadapi Disrupsi Profesi di Era Library 4.0: Sebuah Literatur Review
Authors: Nashihuddin Wahid , Suryono Fajar 
Published: January 2019

Kajian ini bertujuan untuk menjelaskan dan mengetahui kompetensi, upaya, tantangan dan peluang pustakawan dalam menghadapi disrupsi profesi di era library 4.0. Jenis data kajian ini adalah kualitatif dengan sumber data literature review. Literatur yang telah direview kemudian dianalisis isinya berdasarkan pokok bahasan kajian. Hasil kajian ini menunjukkan bahwa pustakawan (di berbagai jenis institusi perpustakaan) sebaiknya meningkatkan kompetensi diri dan melakukan tranformasi perpustakaan untuk persiapan menghadapi disrupsi. Pustakawan perlu meningkatkan kompetensi dirinya secara profesional dalam hal pengelolaan e-resources perpustakaan, kepemimpinan manajerial, literasi digital, dan literasi penelitian. Kompetensi tersebut sebagai bekal pustakawan untuk melakukan tranformasi perpustakaan dan mewujudkan masyarakat berpengetahuan. Selain itu, pustakawan juga harus memandang isu dan fenomena disrupsi sebagai tantangan dan peluang yang positif bagi pengembangan karir profesinya di masa mendatang. Sebagai rekomendasi, pustakawan perlu mengikuti perkembangan teknologi digital library 4.0 dan memperhatikan tiga hal, yaitu penguatan pengetahuan, membangun konektivitas, dan berorientasi pada kebutuhan komunitas. Hal tersebut dilakukan agar pustakawan siap menghadapi disrupsi dan pelayanan perpustakaan yang diberikan kepada pengguna berdampak langsung bagi kesejahteraan masyarakat.ABSTRACTThis study aims to explain and to know the competencies, efforts, challenges and opportunities of librarian for encounter the profession disruption in the library 4.0 era. This type of study data is qualitative with literature review as data sources. The literature that has been reviewed then analyzed based on the subject matter. The results of this study indicate that librarians (in various types of library institutions) should improve their competences and conduct the library transformations to disruption preparation. Librarians need to increase their professional competence in terms of library e-resources management, managerial leadership, digital literacy, and research literacy. These competencies as the librarian asset to transform the library and realize the knowledgeable community. In addition, librarians must look at disruption issue and phenomena as positive challenges and opportunities for professional career development in the future. As the recommendation, librarians need to keep up of digital technology development of library 4.0 and noticed to three things, namely knowledge strengthening, connectivity building, and oriented to the community needs. This is done so that librarians are ready to encounter the disruption and library services provided to users can be impacted for the community welfare.