bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of processing on the mechanical properties and morphology of starch‐based blends for film applications
Authors: Lekube Blanca Maria , Fahrngruber Barbara , Kozich Martin , Wastyn Marnik , Burgstaller Christoph 
Published: May 2019

ABSTRACTThis article describes the effect of processing on the properties and morphology of thermoplastic starch (TPS) and poly(butylene adipate‐co‐terephthalate) (PBAT) blends and films with high starch content. Different process parameters were modified during compounding of blends and extrusion of blown films. Morphology was examined through scanning electron microscopy. Mechanical and optical characterization of films was carried out as well. Decreasing specific throughput during compounding led to an increase in strain at break of the blends from 66 to 497%. The tensile strength increased from 6 to 22 MPa as well. The highest elastic modulus and tear resistance were achieved at intermediate specific throughputs, whereas the maximum TPS particle size and the lowest color difference were obtained at high specific throughputs. A decrease of color difference from 6.4 to 2.2 was observed by reducing the temperature profile in 5 °C. In the case of blown film extrusion, increasing the temperature profile resulted in a reduction of color difference of the films from 7.9 to 4.2. In addition, tensile strength and strain at break slightly increased. Color difference decreased with decreasing screw speed as well. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47990.
Retracted: Physcion Synergistically Enhances the Cytotoxicity of Sorafenib in Hepatocellular Carcinoma
Authors: Pan Xiaoping , Wang Chen , Zhang Ti 
Published: May 2019

ABSTRACTHepatocellular carcinoma (HCC) is a common human malignancy. Physcion is a naturally occurring anthraquinone derivative found in plant and marine sources. Our previous studies have indicated that physcion could suppress tumor growth and induce apoptosis in HCC. This study was aimed to investigate the effect of a combination of physcion and sorafenib on HCC. Our findings indicated that physcion could significantly augment the antiproliferative and proapoptotic activities of sorafenib in vitro and in vivo. Mechanistically, the synergistic effect correlates with physcion‐induced suppression of Notch3/AKT signaling. This preclinical evidence highlights the potential application of physcion in the treatment of HCC. Anat Rec, 302:2171–2177, 2019. © 2019 American Association for Anatomy
Cognitive behavioral therapy for suicide prevention (CBT‐SP): Implications for meeting standard of care expectations with suicidal patients
Authors: Bryan Craig J. 
Published: May 2019

AbstractAccumulating evidence supports the efficacy of cognitive behavioral therapy for suicide prevention (CBT‐SP) as an empirically supported treatment approach for suicidal patients. In light of these findings, several procedures pulled from CBT‐SP have been recommended for standard care with suicidal patients. The present article provides an overview of the procedures used in CBT‐SP and discusses how these procedures meet, or even exceed, standard of care expectations for outpatient mental healthcare clinicians. Finally, the relevance of clinician fidelity to the CBT‐SP model when evaluating standard of care expectations is discussed.
Effectiveness of postoperative radiotherapy after radical cystectomy for locally advanced bladder cancer
Authors: Fischer‐Valuck Benjamin W. , Michalski Jeff M. , Mitra Nandita , Christodouleas John P. , DeWees Todd A. , Kim Eric , Smith Zachary L. , Andriole Gerald L. , Arora Vivek , Bullock Arnold , Carmona Ruben , Figenshau Robert S. , Grubb Robert L. , Guzzo Thomas J. , Knoche Eric M. , Malkowicz S. Bruce , Mamtani Ronac , Pachynski Russell K. , Roth Bruce J. , Zaghloul Mohamed S. , Gay Hiram A. , Baumann Brian C. 
Published: May 2019

AbstractBackgroundLocal‐regional failure (LF) for locally advanced bladder cancer (LABC) after radical cystectomy (RC) is common even with chemotherapy and is associated with high morbidity/mortality. Postoperative radiotherapy (PORT) can reduce LF and may enhance overall survival (OS) but has no defined role. We hypothesized that the addition of PORT would improve OS in LABC in a large nationwide oncology database.MethodsWe identified ≥ pT3pN0‐3M0 LABC patients in the National Cancer Database diagnosed 2004‐2014 who underwent RC ± PORT. OS was calculated using Kaplan‐Meier and Cox proportional hazards regression modeling was used to identify predictors of OS. Propensity matching was performed to match RC patients who received PORT vs those who did not.Results15,124 RC patients were identified with 512 (3.3%) receiving PORT. Median OS was 20.0 months (95% CI, 18.2‐21.8) for PORT vs 20.8 months (95% CI, 20.3‐21.3) for no PORT (P = 0.178). In multivariable analysis, PORT was independently associated with improved OS: hazard ratio 0.87 (95% CI, 0.78‐0.97); P = 0.008. A one‐to‐three propensity match yielded 1,858 patients (24.9% receiving PORT and 75.1% without). In the propensity‐matched cohort, median OS was 19.8 months (95% CI, 18.0‐21.6) for PORT vs 16.9 months (95% CI, 15.6‐18.1) for no PORT (P = 0.030). In the propensity‐matched cohort of urothelial carcinoma patients (N = 1,460), PORT was associated with improved OS for pT4, pN+, and positive margins (P < 0.01 all).ConclusionIn this observational cohort, PORT was associated with improved OS in LABC. While the data should be interpreted cautiously, these results lend support to the use of PORT in selected patients with LABC, regardless of histology. Prospective trials of PORT are warranted.
Prevention of gastric cancer by Helicobacter pylori eradication: A review from Japan
Authors: Uno Yoshiharu 
Published: May 2019

AbstractJapan introduced a Helicobacter pylori eradication therapy strategy in 2013, with the aim of decreasing the number of gastric cancer‐related death, the number of new cases of gastric cancer, and associated medical costs. Five years have passed since then, but no reduction in the annual number of gastric cancer has been observed. In addition, it was suggested that the number of deaths due to gastric cancer could be reduced to 30,000 a year by 2020, but the annual death toll in 2017 remained at more than 45,000. Based on the above evidence, it was examined whether it was possible to reach the target value based on the data from the last 5 years. The number of deaths per year in 2020 is predicted to be more than 40,000, which is clearly different from the target value. Logically, the effect of the strategy might appear by 2023. However, there is a possibility that the risk of gastric cancer may increase in some populations due to the influence of proton pump inhibitors and dysbiosis in the gastric microbiome. To solve these problems, combined therapy with PPIs and aspirin for patients after H pylori eradication should be considered.
Intervention training using peer role‐play and standardised patients in psychodynamic psychotherapy trainees
Authors: Nikendei Christoph , Huber Julia , Ehrenthal Johannes C. , Herzog Wolfgang , Schauenburg Henning , Schultz Jobst‐Hendrik , Dinger Ulrike 
Published: May 2019

AbstractBackgroundInnovative teaching models promoting beneficial therapist behaviour are central to the improvement of psychotherapeutic practice. This study investigated the effects of peer role‐play (RP) and standardised patients (SP) in the context of an intervention skill training course during psychodynamic psychotherapy training.MethodsIn a mixed‐method approach, effects of intervention training with RP and SP on trainees’ self‐efficacy and intervention use during treatment were investigated using trainees’ self‐report questionnaires, qualitative interviews and psychotherapy session observer ratings. Twenty graduate psychotherapy students (17 female; mean age 36 years) participated in an intervention skill seminar. We assessed subjective ratings of intervention competence before and after training as well as acceptance of the training format. For a subsample of 11 participants, we examined changes in frequency and competency of intervention use with session‐based observer ratings during their current outpatient treatments. Furthermore, 10 participants reflected on their training experiences in open interviews, evaluated using inductive content analysis.FindingsThe trainees’ self‐efficacy for the trained interventions increased significantly after training. The training was well accepted and subjectively associated with learning success. Training transfer effects were observed regarding higher frequency and competence in the domain of clarifying and mirroring interventions during participants’ outpatient psychotherapy sessions. Qualitative analysis showed training effects for self‐reflection regarding intervention use, while also promoting the development of therapeutic self‐understanding.ConclusionOur findings provide further evidence that RP and SP training can assist the development of psychotherapy skills. Hence, the regular implementation of RP and SP training during graduate psychotherapy training seems feasible.
Management of S‐ICD lead in a patient requiring sternotomy
Authors: Saour Basil , Kaplan Rachel , Ward Austin , Churyla Andrei , Kim Susan , Knight Bradley 
Published: May 2019

Key Clinical MessageIn patients who have had a prior subcutaneous ICD implanted, a sternotomy can be safely performed without the need for replacement of the ICD. Appropriate tools and closure technique during reimplantation are essential for this to be a possibility.
Comparison of Storage Methods for Microfluidically Produced Water‐in‐Oil Droplets
Authors: Grösche Maximilian , Korvink Jan G. , Rabe Kersten S. , Niemeyer Christof M. 
Published: May 2019

AbstractMicrofluidically produced water‐in‐oil droplets are an important platform for biochemical research. To investigate the structural integrity of droplets during transfer and storage processes, different methods were compared. Storage as isolated droplets inside plastic tubing or a designed microfluidic chamber led to moderate decreases in droplet volume but only slight changes in monodispersity, whereas bulk storage in an Eppendorf cup led to the complete loss of monodispersity. It is further demonstrated that on‐chip storage of the droplets in a fluidic microcavity array avoids coalescence and enables a reduction in volume with the concurrent increase in the concentration of entrapped proteins, which is relevant for applications in life science.
Crystal Structures of DOTMA Chelates from Ce3+ to Yb3+: Evidence for a Continuum of Metal Ion Hydration States
Authors: Woods Mark , Payne Katherine M. , Valente Edward J. , Kucera Benjamin E. , Young Victor G. 
Published: May 2019

AbstractThe crystal structures of chelates formed between each stable paramagnetic lanthanide ion and the octadentate polyamino carboxylate ligand DOTMA are described. A total of 23 individual chelates structures were obtained; in each chelate the coordination geometry around the metal ion is best described as a twisted square antiprism (torsion angle −25.0°–−31.4°). Despite the uniformity of the general coordination geometry provided by the DOTMA ligand, there is a considerable variation in the hydration state of each chelate. The early Ln3+ chelates are associated with a single inner sphere water molecule; the Ln‐OH2 interaction is remarkable for being very long. After a clear break at gadolinium, the number of chelates in the unit cell that have a water molecule interacting with the Ln3+ decreases linearly until at Tm3+ no water is found to interact with the metal ion. The Ln‐OH2 distance observed in the chelates of the later Ln3+ ions are also extremely long and increase as the ions contract (2.550–2.732 Å). No clear break between hydrated and dehydrated chelates is observed; rather this series of chelates appear to represent a continuum of hydration states in which the ligand gradually closes around the metal ion as its ionic radius decreases (with decreased hydration) and the metal drops down into the coordination cage.
Hyperuricemia treatment in acute heart failure patients does not improve their long‐term prognosis: A propensity score matched analysis from the AHEAD registry
Authors: Pavlusova Marie , Jarkovsky Jiri , Benesova Klara , Vitovec Jiri , Linhart Ales , Widimsky Petr , Spinarova Lenka , Zeman Kamil , Belohlavek Jan , Malek Filip , Felsoci Marian , Kettner Jiri , Ostadal Petr , Cihalik Cestmir , Spac Jiri , Al‐Hiti Hikmet , Fedorco Marian , Fojt Richard , Kruger Andreas , Malek Josef , Mikusova Tereza , Monhart Zdenek , Bohacova Stanislava , Pohludkova Lidka , Rohac Filip , Vaclavik Jan , Vondrakova Dagmar , Vyskocilova Klaudia , Bambuch Miroslav , Dostalova Gabriela , Havranek Stepan , Svobodová Ivana , Dusek Ladislav , Spinar Jindrich , Miklik Roman , Parenica Jiri 
Published: May 2019

BackgroundHyperuricemia is associated with a poorer prognosis in heart failure (HF) patients. Benefits of hyperuricemia treatment with allopurinol have not yet been confirmed in clinical practice. The aim of our work was to assess the benefit of allopurinol treatment in a large cohort of HF patients.MethodsThe prospective acute heart failure registry (AHEAD) was used to select 3160 hospitalized patients with a known level of uric acid (UA) who were discharged in a stable condition. Hyperuricemia was defined as UA ≥500 μmoL/L and/or allopurinol treatment at admission. The patients were classified into three groups: without hyperuricemia, with treated hyperuricemia, and with untreated hyperuricemia at discharge. Two‐ and five‐year all‐cause mortality were defined as endpoints. Patients without hyperuricemia, unlike those with hyperuricemia, had a higher left ventricular ejection fraction, a better renal function, and higher hemoglobin levels, had less frequently diabetes mellitus and atrial fibrillation, and showed better tolerance to treatment with angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers and/or beta‐blockers.ResultsIn a primary analysis, the patients without hyperuricemia had the highest survival rate. After using the propensity score to set up comparable groups, the patients without hyperuricemia had a similar 5‐year survival rate as those with untreated hyperuricemia (42.0% vs 39.7%, P = 0.362) whereas those with treated hyperuricemia had a poorer prognosis (32.4% survival rate, P = 0.006 vs non‐hyperuricemia group and P = 0.073 vs untreated group).ConclusionHyperuricemia was associated with an unfavorable cardiovascular risk profile in HF patients. Treatment with low doses of allopurinol did not improve the prognosis of HF patients.
Nonadherent behaviors among young women on adjuvant endocrine therapy for breast cancer
Authors: Wassermann Johanna , Gelber Shari I. , Rosenberg Shoshana M. , Ruddy Kathryn J. , Tamimi Rulla M. , Schapira Lidia , Borges Virginia F. , Come Steven E. , Meyer Meghan E. , Partridge Ann H. 
Published: May 2019

BackgroundYoung age is a known factor associated with suboptimal adherence to endocrine therapy (ET) for adjuvant breast cancer (BC) treatment. This study was aimed at assessing nonadherent behaviors and associated factors among young women with early‐stage hormone receptor–positive BC.MethodsAs part of a multicenter, prospective cohort of women with a diagnosis of BC at or under the age of 40 years, participants were surveyed 30 months after their diagnosis about adherent behaviors. Among those who reported taking ET, adherence was measured with a 3‐item Likert‐type scale: Do you ever forget to take your ET? If you feel worse when you take your ET, do you stop taking it? Did you take your ET exactly as directed by your doctor over the last 3 months? Women reporting at least 1 nonadherent behavior were classified as nonadherers. Variables with a P value <.20 were included in a multivariable logistic model.ResultsAmong 384 women, 194 (51%) were classified as nonadherers. Univariate factors that retained significance in the multivariable model included educational level (odds ratio [OR], 0.50 for high vs low; P = .04), level of social support according to the Medical Outcome Study Social Support Survey (OR, 0.98 per 1 point; P = .01), and confidence with the decision regarding ET measured on a 0 to 10 numerical scale (OR, 0.63 for high vs low; P = .04).ConclusionsFindings from this study could help to identify young patients at higher risk for nonadherence. Interventions adapted to the level of education and aimed at reinforcing support and patients' confidence in their decision to take ET could improve adherence and associated outcomes in this population.
Additive and interactive cumulative effects on boreal landbirds: winners and losers in a multi‐stressor landscape
Authors: Mahon C. Lisa , Holloway Gillian L. , Bayne Erin M. , Toms Judith D. 
Published: May 2019

AbstractStressors created by multiple resource industries can result in cumulative effects over time and space. Many studies have evaluated single stressors and assumed that cumulative effects can be understood by adding stressors together. However, there is growing evidence that interactive effects are important in structuring biological communities. We evaluated whether the effects of multiple stressors in the boreal forest (linear features, energy, forestry) combine additively or interactively by testing a candidate model set of 12 cumulative effects models of abundance for 27 landbird species. We fitted paired additive and interactive Generalized Additive Models and examined model predictions in the Athabasca Oil Sands Area of Alberta, Canada, and a theoretical no‐disturbance version of the study area. Of the 27 species examined, an additive disturbance model was the best for nine species, while an interactive disturbance model was the best for 11 species. In the current study area, disturbance models predicted strong increases in abundance for species associated with deciduous forest and open habitats (winning species) and moderate decreases for species associated with conifer forest (losing species). We found a 15% change in landbird community composition between the current study area, with 8.4% disturbance, and the theoretical no‐disturbance study area. Complex synergistic and antagonistic interactions among stressors were observed for 39% of landbird species, with the majority of interactions observed being synergistic. Stressors with relatively small disturbance areas, such as narrow linear disturbances, frequently interacted with other stressors to affect species’ responses, and energy sector stressors often had additive or interactive effects with forestry stressors. Interactive cumulative effects from multiple sectors will make it increasingly difficult for industry and land managers to manage impacts unless interactions among stressors are incorporated into cumulative effects assessments and regional land use planning processes.
Propagule pressure and genetic diversity enhance colonization by a ruderal species: a multi‐generation field experiment
Authors: Hovick Stephen M. , Whitney Kenneth D. 
Published: May 2019

AbstractColonization is a critical filter, setting the stage for short‐term and long‐term population success. Increased propagule pressure (e.g., more founding individuals) usually enhances colonization; however, this pattern may be driven by purely numeric effects, population genetic diversity effects, or both. To determine the independent and interactive effects of propagule pressure and genetic diversity, we conducted a seed addition experiment in the field using the ruderal annual Arabidopsis thaliana. Propagule pressure treatments spanned five levels, from 32 to 960 seeds per 0.25‐m2 plot. Founder populations were composed of one, four, or eight genotypes and exposed to ambient or reduced levels of interspecific competition. Genotype monocultures were included to quantify additive vs. non‐additive effects. Populations were followed for three generations, with abundance, population persistence and genotype retention (the proportion of introduced genotypes persisting over time) as the major response variables. Increased propagule pressure enhanced abundance immediately following introduction, particularly where nutrient availability was high and competition reduced. Greater propagule pressure also increased the likelihood of population persistence and genotype retention through three generations. However, most populations experienced rapid abundance declines over time, yielding no relationship between propagule pressure and third‐generation abundance across persisting populations. Under reduced competition, increased genetic diversity led to a marginal increase in persistence through the third generation that was more pronounced, and statistically significant, in low nutrient conditions. Genetic diversity did not affect persistence through the first generation, thus indicating that genetic diversity effects strengthened over time. Nevertheless, genotypic mixture populations fell short of expectations based on performance in monocultures (negative non‐additive effects). Increased genetic diversity was also associated with abundance declines, largely due to one particularly high‐performing genotype in the lowest diversity treatments (i.e., genotypic identity effects). Overall, our results indicate that increases in both propagule pressure and genetic diversity can enhance colonization success but are highly context dependent. They also highlight novel ways in which both factors can impact the retention of introduced genetic diversity over time. Our findings pinpoint the determinants of a fundamental population process and have key implications for applications where enhanced or suppressed colonization is desired, including ecological restoration and invasive species management.
Hydralazine and nitrates in the treatment of heart failure with reduced ejection fraction
Authors: Al‐Mohammad Abdallah 
Published: May 2019

AbstractHydralazine and nitrate combination was the first treatment that showed improved survival of patients with heart failure with reduced left ventricular ejection fraction (HFREF) in the Vasodilator Heart Failure Trial (V‐HeFT trial) in 1986. This showed a 34% reduction of mortality at 2 years of follow‐up in patients with advanced heart failure (New York Heart Association Class IV). The angiotensin‐converting enzyme inhibitor (ACEi), beta‐blockers, mineralocorticoid receptor antagonists, and most recently sacubitril–valsartan have superseded the combination of hydralazine and nitrates. However, the latter combination does have a place bridging the survival gap of Black patients with HFREF when added to their standard therapy. This was demonstrated in the African‐American Heart Failure Trial (A‐HeFT trial) in 2004 when the risk reduction in the Black patients was 43% compared with that in the placebo. This combination may have a potential use in patients with contraindications to the use of ACEi, angiotensin receptor blockers, and sacubitril–valsartan. This is suggested by both the European Society of Cardiology (ESC) Guidelines and the guidelines of the National Institute for Health and Care Excellence (NICE). In this perspective, the role of the combination of hydralazine and nitrates in the treatment of HFREF is reviewed through a synopsis of the evidence base consisting of three randomized controlled studies, several further analyses of subgroups within those trials, a systemic review, and two large observational studies of registry cohorts. The place of the combination in the treatment cascades proposed by heart failure guidelines of the ESC and NICE is explored. This perspective is to remind us of their appropriate roles, particularly given the findings of underuse of this combination in people of African ancestry in Europe.