bluuebunny/crossref_metadata_2025_split huggingface dataset:
First-in-Human Phase I, Dose-Escalation and -Expansion Study of Telisotuzumab Vedotin, an Antibody–Drug Conjugate Targeting c-Met, in Patients With Advanced Solid Tumors
Authors: Strickler John H. , Weekes Colin D. , Nemunaitis John , Ramanathan Ramesh K. , Heist Rebecca S. , Morgensztern Daniel , Angevin Eric , Bauer Todd M. , Yue Huibin , Motwani Monica , Parikh Apurvasena , Reilly Edward B. , Afar Daniel , Naumovski Louie , Kelly Karen 
Published: October 2018

Purpose This first-in-human study evaluated telisotuzumab vedotin (Teliso-V), formerly called ABBV-399, an antibody–drug conjugate of the anti–c-Met monoclonal antibody ABT-700 and monomethyl auristatin E. Materials and Methods For dose escalation, three to six patients with advanced solid tumors were enrolled in eight cohorts (0.15 to 3.3 mg/kg). The dose-expansion phase enrolled patients with non–small-cell lung cancer (NSCLC) with c-Met–overexpressing tumors (c-Met positive; immunohistochemistry membrane H-score ≥ 150). Patients received Teliso-V monotherapy intravenously on day 1 once every 3 weeks. Safety, tolerability, pharmacokinetics, and maximum tolerated dose were determined. Results Forty-eight patients were enrolled (median age, 65 years; 35.4% NSCLC; median four prior therapies). One patient each in the 3.0-mg/kg (n = 9) and 3.3-mg/kg (n = 3) cohorts experienced dose-limiting toxicities. Although the maximum tolerated dose was not formally identified, the recommended phase II dose was defined as 2.7 mg/kg on the basis of overall safety and tolerability. The most frequent treatment-emergent adverse events (any grade) were fatigue (42%), nausea (27%), constipation (27%), decreased appetite (23%), vomiting (21%), dyspnea (21%), diarrhea (19%), peripheral edema (19%), and neuropathy (17%). The most frequent Teliso-V–related grade ≥ 3 adverse events were fatigue, anemia, neutropenia, and hypoalbuminemia (4% each). Teliso-V and total antibody pharmacokinetics were approximately dose proportional, with a mean harmonic half-life of 2 to 4 days each. Prospective screening identified 35 (60%) of 58 patients with c-Met–positive NSCLC. Of 16 patients with c-Met–positive NSCLC who were treated with Teliso-V 2.4 to 3.0 mg/kg, three (18.8%; 95% CI, 4.1% to 45.7%) achieved a partial response (median response duration, 4.8 months; median progression-free survival, 5.7 months; 95% CI, 1.2 months to 15.4 months). No other patients experienced a response. Conclusion Teliso-V monotherapy demonstrated favorable safety and tolerability profiles, with encouraging evidence of antitumor activity in patients with c-Met–positive NSCLC.
The low-down on sleeping down low: pigeons shift to lighter forms of sleep when sleeping near the ground
Authors: Tisdale Ryan K. , Lesku John A. , Beckers Gabriel J. L. , Vyssotski Alexei L. , Rattenborg Niels C. 
Published: October 2018

ABSTRACT
Sleep in birds is composed of two distinct sub-states, remarkably similar to mammalian slow-wave sleep (SWS) and rapid eye movement (REM) sleep. However, it is unclear whether all aspects of mammalian sleep are present in birds. We examined whether birds suppress REM sleep in response to changes in sleeping conditions that presumably evoke an increase in perceived predation risk, as observed previously in rodents. Although pigeons sometimes sleep on the ground, they prefer to sleep on elevated perches at night, probably to avoid nocturnal mammalian ground predators. Few studies to date have investigated how roosting sites affect sleep architecture. We compared sleep in captive pigeons on days with and without access to high perches. On the first (baseline) day, low and high perches were available; on the second day, the high perches were removed; and on the third (recovery) day, the high perches were returned. The total time spent sleeping did not vary significantly between conditions; however, the time spent in REM sleep declined on the low-perch night and increased above baseline when the pigeons slept on the high perch during the recovery night. Although the amount of SWS did not vary significantly between conditions, SWS intensity was lower on the low-perch night, particularly early in the night. The similarity of these responses between birds and mammals suggests that REM sleep is influenced by at least some ecological factors in a similar manner in both groups of animals.
Wkład antropologii kulturowej w studia nad niepełnosprawnością
Authors: Borowska-Beszta Beata 
Published: October 2018

Interdisciplinary studies on disability are conducted in the world by scholars from different disciplines and sub-disciplines, including special education. This article deals with an analysis of the evolution of the concept of disability studies and its’ implementation in anthropology that was narrowed to cultural anthropology, primarily of American roots with references to British social anthropology. The basic question, which I answer from the perspective of the cultural anthropologists, is formulated as follows: why cultural anthropology is important in the disability studies? I give answers in the context of: ontological, epistemological, rhetorical and political issues. Anthropological analyzes are preceded by definitions of disability studies after Stteven aylor, Bonnie Shoultz, Pamela Walker; Colin Barnes; Dan Goodley; Sharon L. Snyder; David T. Mitchell and Ronald J. Berger.
Mechanizmy motywacji a wybór strategii uczenia się uczniów szkół gimnazjalnych z i bez specyficznych trudności w uczeniu się
Authors: Kucharczyk Izabella , Dłużniewska Agnieszka 
Published: October 2018

The purpose of this article is to present the results of research concern setting of motivated and cognitive strategies in learning goals achieving by students with and without dyslexia in secondary school. The study included 110 students studying in secondary schools in the Mazovian region. The study used questionnaire Goal Orientations and Learning Strategies Survey (GOAL-S) M. Dowson and D.M. McInerney (2004) in the Polish adaptation of A. Dłużniewska and I. Kucharczyk. Detailed analysis of the results indicates the relationship between the kind of motivation and choice of cognitive and metacognitive strategies of learning. The current study allows to extract factors that are important in achieving success in academic achievements of students with and without special educational needs.
Słuchowo-językowe funkcjonowanie dzieci bilateralnie zaimplantowanych wszczepem ślimakowym w trybie sekwencyjnym, doniesienie wstępne
Authors: Magierska-Krzysztoń Magdalena 
Published: October 2018

Severe hearing damage in the prenatal period or when the baby is born is a disability that significantly impairs the correct functioning in the society of hearing people. A particularly perceptible consequence of severe hearing impairment is the lack or significant delay in the development of speech and language acquisition. Thanks to the use of cochlear implants, the Program Chirurgicznego Leczenia Głuchoty Metodą Wszczepów Ślimakowych [Program of Surgical Treatment of Deafness With the Method of Cochlear Implantation] allows children with perceptive deafness for the access to speech sounds through the auditory pathway. It gives them an opportunity to develop speech and language and in the future – the ability to satisfactorily communicate with other people. The study covered 54 born-deaf children, bilaterally implanted in the sequential mode. The implantation was performed at the Department of Otolaryngology and Laryngological Oncology of the Poznan University of Medical Sciences. The results indicate a constant, dynamic increase of auditory and linguistic-communication skills in the examined group.
Od wczesnych zwiastunów autyzmu po przywiązanie – rozwój relacji społecznych dzieci ze spektrum autyzmu w kontaktach z bliskimi
Authors: Winczura Barbara 
Published: October 2018

Autism is a vast developmental disorder with significant delays and problems in participation in alternate social interactions. Studies show that nearly half of the population with various forms of autism participates in social life, although their profile of emotional and social deficits remains highly diversified. Impairment within a social sphere includes a limited disposition and ability to recognize, to understand and to engage in human contact and interpersonal communication. Parents /guardians are the first observers of disturbing behaviors of a child and the first initiators of building a close relationship with their offspring. Their observations are the determinants of the criteria of early detection of autism spectrum disorders. The biggest problem for parents is the inability of their children with autism to show affection. The goal of this article is to show the development profile of social relationships of young children with autism in contacts with their relatives and the analysis of conditions in the child – parent attachment relationship in this group of disorders.
Correlating topology and thermodynamics to predict protein structure sensitivity to point mutations
Authors: Rodriguez Paula Milan , Stratmann Dirk , Duprat Elodie , Papandreou Nikolaos , Acuna Ruben , Lacroix Zoé , Chomilier Jacques 
Published: October 2018

Abstract
The relation between distribution of hydrophobic amino acids along with protein chains and their structure is far from being completely understood. No reliable method allows ab initio prediction of the folded structure from this distribution of physicochemical properties, even when they are highly degenerated by considering only two classes: hydrophobic and polar. Establishment of long-range hydrophobic three dimension (3D) contacts is essential for the formation of the nucleus, a key process in the early steps of protein folding. Thus, a large number of 3D simulation studies were developed to challenge this issue. They are nowadays evaluated in a specific chapter of the molecular modeling competition, Critical Assessment of Protein Structure Prediction. We present here a simulation of the early steps of the folding process for 850 proteins, performed in a discrete 3D space, which results in peaks in the predicted distribution of intra-chain noncovalent contacts. The residues located at these peak positions tend to be buried in the core of the protein and are expected to correspond to critical positions in the sequence, important both for folding and structural (or similarly, energetic in the thermodynamic hypothesis) stability. The degree of stabilization or destabilization due to a point mutation at the critical positions involved in numerous contacts is estimated from the calculated folding free energy difference between mutated and native structures. The results show that these critical positions are not tolerant towards mutation. This simulation of the noncovalent contacts only needs a sequence as input, and this paper proposes a validation of the method by comparison with the prediction of stability by well-established programs.
Introduction
Authors: Gabriel Gösta Ingvar 
Published: October 2018

AbstractThe introduction provides the theoretical framework for the volume ranging from Kant’sCritique of Pure Reasonvia Landsberger’s concept ofEigenbegrifflichkeit(conceptual autonomy) to Assyriological research on ancient Near Eastern epistemic practices, especially Van De Mieroop’s recent volumePhilosophy Before the Greeks. Then the introduction explores the field of the history of philosophy with special consideration given to those variants that focus on non-Greek and non-Western versions of philosophy. Thus, it asks whether and how ancient Mesopotamia can be investigated in such a framework. After that the structure of the volume is explained, and a brief summary of each contribution is given. The introduction concludes by thanking the many people who have helped to make this volume possible.
Antecedents of red cell transfusion in a large contemporary obstetric cohort
Authors: Enright Siobhan , Varadkar Sonia , Demaio Alison , Flynn Catherine , Ni Áinle Fionnuala , Hehir Mark P. 
Published: October 2018

Abstract

Background
Hemorrhage is a critical contributor to maternal morbidity but estimation of blood loss at delivery is frequently inaccurate. Due to this inaccuracy we sought to examine blood transfusion as a surrogate marker for morbidity in a large non-population based consecutive cohort.

Methods
A retrospective analysis of prospectively gathered data was carried out at two university institutions serving a heterogeneous urban obstetric population from January to December 2016. Data were analyzed to determine whether individual characteristics were associated with perinatal transfusion. Hematological indices and requirement for other blood products were also characterized.

Results
A total of 16,581 deliveries were recorded during the study and 1.7% (289/16,581) of the cohort required red cell transfusion. Those who received transfusion were more likely to be nulliparous, and to deliver <37 weeks’ or >42 weeks’ gestation. They were also more likely to have a macrosomic infant (birthweight >4 kg) and to have had a multiple pregnancy. Characteristics not associated with risk of transfusion included obesity [18% (52/289) vs. 15% (2445/16,292); P=0.18], and maternal age ≥35 years [28% (82/289) vs. 33% (5537/16,292); P=0.05]. Additional blood products were necessary in a small number of patients who received red cells.

Conclusion
The rate of transfusion in a contemporary Irish cohort has risen compared with previous data. Several variables associated with transfusion are consistent with older studies but importantly; maternal obesity and advanced maternal age are not associated with transfusion. These data may encourage the investment of resources in a population previously considered low-risk and, following future studies, to improve strategies aimed at limiting blood transfusion.
Predication and Modality in Kant’s Critique of the Ontological Argument
Authors: Pasternack Lawrence 
Published: October 2018

Abstract
There is perhaps no more famous objection to the Ontological Argument (OA) than Kant’s contention that existence is not a predicate (E~P). However, this is not his only objection against the Ontological Argument. It is rather part of a more comprehensive attack on the OA, one that contains at least four distinct arguments, only one of which involves (E~P). It is the purpose of this paper to explore Kant’s case for (E~P), consider three contemporary strategies used to reinforce it, assess their merits, and then finally briefly present Kant’s three further arguments
Hidden Antinomies of Practical Reason, and Kant’s Religion of Hope
Authors: Zuckert Rachel 
Published: October 2018

Abstract
In the Critique of Practical Reason, Kant argues that morality obliges us to believe in the immortality of the soul and the existence of God. I argue, however, that in two late essays - “The End of All Things” and “On the Miscarriage of all Philosophical Trials in Theodicy” - Kant provides moral counterarguments to that position: these beliefs undermine moral agency by giving rise to fanaticism or fatalism. Thus, I propose, the Kantian position on the justification of religious belief is ultimately antinomial. One ought, moreover, to understand Kant’s considered position concerning the immortality of the soul and the existence of God to be similar to that he proposes concerning the theoretical ideas of reason in the Appendix to the Dialectic of the Critique of Pure Reason: they are necessary as regulative ideas guiding moral action, not endorsed or even postulated as propositions. In other words, they are subject matters not of belief, but of hope.
Innovative technologies for chemical security
Authors: Forman Jonathan E. , Timperley Christopher M. , Aas Pål , Abdollahi Mohammad , Alonso Isel Pascual , Baulig Augustin , Becker-Arnold Renate , Borrett Veronica , Cariño Flerida A. , Curty Christophe , Gonzalez David , Kovarik Zrinka , Martínez-Álvarez Roberto , Mikulak Robert , de Souza Nogueria Evandro , Ramasami Ponnadurai , Raza Syed K. , Saeed Ahmed E. M. , Takeuchi Koji , Tang Cheng , Trifirò Ferruccio , van Straten Francois Mauritz , Waqar Farhat , Zaitsev Volodymyr , Zina Mongia Saïd , Grolmusová Katarína , Valente Guy , Payva Marlene , Sun Siqing , Yang Amy , van Eerten Darcy 
Published: October 2018

AbstractAdvances across the chemical and biological (life) sciences are increasingly enabled by ideas and tools from sectors outside these disciplines, with information and communication technologies playing a key role across 21stcentury scientific development. In the face of rapid technological change, the Organisation for the Prohibition of Chemical Weapons (OPCW), the implementing body of the Chemical Weapons Convention (“the Convention”), seeks technological opportunities to strengthen capabilities in the field of chemical disarmament. The OPCW Scientific Advisory Board (SAB) in its review of developments in science and technology examined the potential uses of emerging technologies for the implementation of the Convention at a workshop entitled “Innovative Technologies for Chemical Security”, held from 3 to 5 July 2017, in Rio de Janeiro, Brazil. The event, organized in cooperation with the International Union of Pure and Applied Chemistry (IUPAC), the National Academies of Science, Engineering and Medicine of the United States of America, the Brazilian Academy of Sciences, and the Brazilian Chemical Society, was attended by 45 scientists and engineers from 22 countries. Their insights into the use of innovative technological tools and how they might benefit chemical disarmament and non-proliferation informed the SAB’s report on developments in science and technology for the Fourth Review Conference of the Convention (to be held in November 2018), and are described herein, as are recommendations that the SAB submitted to the OPCW Director-General and the States Parties of the Convention. It is concluded that technologies exist or are under development that could be used for investigations, contingency, assistance and protection, reducing risks to inspectors, and enhancing sampling and analysis.
How Cells Fold the Cerebral Cortex
Authors: Borrell Víctor 
Published: October 2018

Folding of the cerebral cortex is as highly intriguing as poorly understood. At first sight, this may appear as simple tissue crumpling inside an excessively small cranium, but the process is clearly much more complex and developmentally predetermined. Whereas theoretical modeling supports a critical role for biomechanics, experimental evidence demonstrates the fundamental role of specific progenitor cell types, cellular processes, and genetic programs on cortical folding.Dual Perspectives Companion Paper:How Forces Fold the Cerebral Cortex, by Christopher D. Kroenke and Philip V. Bayly
Heroes, Presidents, and Politics
Authors: Alexander Jeffrey C. 
Published: October 2018

In 2008, we needed a hero. We still do. Political narratives are all about heroes, and never was it more plainly evident than in the 2008 presidential contest between Barack Obama and John McCain. Like all candidates, Obama and McCain worked to craft their own heroic narratives, from despair to redemption to, each hoped, glory. And sociologists watched as the American public joined in on this process, seeing their hopes, dreams, and concerns filtered through opinion polls that were used to form the politicians into just the heroes these times called for. Candidates and voters colluded in myth-making in that block-buster election, but how has the victor's heroic reputation served him as he holds office?
Determinantes do Desempenho Empreendedor e Inovador nas Regiões Transfronteiriças
Authors: Natário Maria Manuela , Martins Braga Ascensão , Fernandes Gonçalo Poeta 
Published: October 2018

Este trabalho de pesquisa incide sobre novas abordagens e conhecimentos relativos aos processos de empreendedorismo e inovação que podem ocorrer em regiões de fronteira. Os principais resultados alcançados provêm de um estudo exploratório com as empresas das regiões de fronteira da Beira Interior Norte e Província de Salamanca, localizadas respetivamente na fronteira de Portugal e Espanha. Apesar das condições desfavoráveis desta região de fronteira, em face da sua evolução demográfica e desarticulação económica verificada nas últimas três décadas, detetam- se fatores que influenciam o desempenho empreendedor das empresas desta região. Assim, esta pesquisa mostra como o ambiente empresarial pode ser incentivado e renovado nas regiões de fronteira periféricas, como a região em estudo, através do desenvolvimento de redes locais, da intensificação da internacionalização e do reforço das infraestruturas locais relacionadas com as indústrias regionais e locais. Consequentemente, esta pesquisa oferece um caso pioneiro baseado num tipo de empreendedorismo que, em essência, é diferente do verificado em regiões centrais, isto é, de dinâmicas positivas de desenvolvimento e de forte urbanidade. Os resultados sugerem que os fatores considerados importantes para influenciar o desempenho inovador e empreendedor das regiões de fronteira prendem-se com a tipologia da empresa em setores predominantemente enraizados na região, com os recursos e o processo de criação facilitado por menor burocracia, com o perfil do empresário, com a internacionalização do mercado-alvo e com os canais de divulgação e comercialização adotados.
Taboo Narratives: Teaching Palestine and the Palestinians
Authors: Farah Randa 
Published: October 2018

Abstract
To speak “truth to power” is not merely an intellectual task but a mission statement and a moral compass, especially for anthropologists. Writing and speaking out about the effects of settler-colonialism on Palestinians has become the litmus test of such a stance. In western societies, especially in North America, Palestine is a taboo subject, where fear of being denied tenure or even expelled for speaking out has prevented a protracted history of Palestinian suffering, dispossession, and expulsion from being heard or known. Teaching about it therefore acquires a heightened significance and demands the deconstruction of dominant myths, despite the difficulties.
Üniversite Öğrencilerinin Şehir Markası Algısı: Bandırma Örneği
Authors: TEKTAŞ Necla , TEKTAŞ Mehmet 
Published: October 2018

Şehir markası; geçmişten
günümüze şehrin sahip olduğu kültürel mirası ve onu meydana getiren toplumsal
yapıyı, beşeri özellikleri, kimliği, sanatı, mimarisi gibi birçok faktörü kapsayan
bir kavramdır. Çalışma öğrencilerin şehir markası algıları ve şehirden
memnuniyet derecelerini tespit etmek amacıyla yapılmıştır. Veriler 2017-2018
bahar döneminde Bandırma Onyedi Eylül Üniversitesi öğrencilerinden kolayda
örnekleme yöntemiyle anket uygulanarak toplanmıştır. Uygulanan anket iki
bölümden oluşmaktadır. Birinci bölümde öğrencilerin demografik bilgileri ve
ikinci bölümde şehir markası ölçeği yer almaktadır. İstatistik analizlerde frekans analizi,
faktör analizi ve regresyon analizi teknikleri kullanılmıştır. Öğrencilerin
şehir markalaşmasında şehirden beklentileri ve şehirden memnuniyetleri
değerlendirilmiş ve yorumları yapılmıştır.