bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal and seismic hints for chimney type cross-stratal fluid flow in onshore basins
Authors: Dentzer Jacques , Bruel Dominique , Delescluse Matthias , Chamot-Rooke Nicolas , Beccaletto Laurent , Lopez Simon , Courrioux Gabriel , Violette Sophie 
Published: October 2018

AbstractWhen modelling onshore sedimentary basins, modellers generally assume that semi-permeable layers (aquitards) greatly restrict vertical flow between aquifers. Aquitards are therefore considered as confining media and vertical flow is assumed to take place mainly within localised permeable faults, if any. In the offshore context, however, interpretation of seismic data frequently provides evidence of fluid flow between sedimentary layers via structurally disrupted formations (pervasive fractures) recognised as zones of reduced seismic amplitude and generically called “chimneys”. Here we show that chimneys are also present onshore, and that they crosscut confining layers. In the Anglo-Paris Basin, seismic data suggest 1 to 2 km wide zones of disrupted seismic signal spatially correlated to a hitherto unexplained major temperature anomaly of 20 °C. When included in geothermal models using a five-order increase in permeabilities with respect to confining layers, we find that fluid flows vertically through aquifers and confining layers, thereby explaining this major temperature anomaly. Despite the importance of their hydrodynamic and thermal impacts, chimneys – less obvious than faults – have been overlooked as fluid flow paths in many onshore sedimentary basins exploited for their resources. This indicates a clear need for better understanding of pervasive flow paths, especially as the resources and properties of basins (i.e. conventional and unconventional hydrocarbons, geothermal potential, CO2 storage, nuclear waste repository, drinking water, etc.) are increasingly being harnessed.
Mesophase behavior of new linear supramolecular hydrogen-bonding complexes
Authors: Ahmed H. A. , Hagar M. , Aljuhani A. 
Published: October 2018

PLM textures of (a) SmA phase of II8 at 105.0 °C; (b) SmC phase of complex I10/II8 at 183.0 °C; and (c) nematic phase the complex I10/II8 at 225.0 °C.
Crustal heating in accreting neutron stars from the nuclear energy-density functional theory
Authors: Fantina A. F. , Zdunik J. L. , Chamel N. , Pearson J. M. , Haensel P. , Goriely S. 
Published: October 2018

Context.X-ray observations of soft X-ray transients in quiescence suggest the existence of heat sources in the crust of accreted neutron stars. Heat is thought to be released by electroweak and nuclear processes triggered by the burying of ashes of X-ray bursts.Aims.The heating in the crust of accreting neutron stars is studied using a fully quantum approach taking consistently into account nuclear shell effects.Methods.To this end, we have followed the evolution of ashes made of56Fe employing the nuclear energy-density functional theory. Both the outer and inner crusts are described using the same functional, thus ensuring a unified and thermodynamically consistent treatment. To assess the role of accretion on the structure of the crust, we have employed the set of accurately calibrated Brussels–Montreal functionals BSk19, BSk20, and BSk21, for which the equations of state of nonaccreted neutron stars have been already calculated. These energy-density functionals were fitted to the same set of nuclear masses but were simultaneously adjusted to realistic neutron-matter equations of state with different degrees of stiffness at suprasaturation densities. For comparison, we have also considered the SLy4 functional.Results. Due to nuclear shell effects, the interior of fully accreted crust is found to be much less stratified than in previous studies. In particular, large regions of the inner crust contain clusters with the magic numberZ = 14. The heat deposited in the outer crust is tightly constrained by experimental atomic mass data. The shallow heating we obtain does not exceed 0.2 MeV per accreted nucleon and is therefore not enough to explain the cooling of some soft X-ray transients. The total heat released in the crust is very sensitive to details of the nuclear structure and is predicted to lie in the range from 1.5 MeV to 1.7 MeV per accreted nucleon.Conclusions.The evolution of an accreted matter element and therefore the location of heat sources are governed to a large extent by the existence of nuclear shell closures. Ignoring these effects in the inner crust, the total heat falls to ∼0.6 MeV per accreted nucleon.
Radiation Dose Optimization in Pediatric Chest CT: Major Indicators of Dose Exposure in 1695 CT Scans over Seven Years
Authors: Esser Michael , Hess Sabine , Teufel Matthias , Kraus Mareen , Schneeweiß Sven , Gatidis Sergios , Schaefer Juergen , Tsiflikas Ilias 
Published: October 2018

Purpose To analyze possible influencing factors on radiation exposure in pediatric chest CT using different approaches for radiation dose optimization and to determine major indicators for dose development.
Materials and Methods In this retrospective study at a clinic with maximum care facilities including pediatric radiology, 1695 chest CT examinations in 768 patients (median age: 10 years; range: 2 days to 17.9 years) were analyzed. Volume CT dose indices, effective dose, size-specific dose estimate, automatic dose modulation (AEC), and high-pitch protocols (pitch ≥ 3.0) were evaluated by univariate analysis. The image quality of low-dose examinations was compared to higher dose protocols by non-inferiority testing.
Results Median dose-specific values annually decreased by an average of 12 %. High-pitch mode (n = 414) resulted in lower dose parameters (p < 0.001). In unenhanced CT, AEC delivered higher dose values compared to scans with fixed parameters (p < 0.001). In contrast-enhanced CT, the use of AEC yielded a significantly lower radiation dose only in patients older than 16 years (p = 0.04). In the age group 6 to 15 years, the values were higher (p < 0.001). The diagnostic image quality of low-dose scans was non-inferior to high-dose scans (2.18 vs. 2.14).
Conclusion Radiation dose of chest CT was reduced without loss of image quality in the last decade. High-pitch scanning was an independent factor in this context. Dose reduction by AEC was limited and only relevant for patients over 16 years.
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Selecting Patients for Lobar Lung Volume Reduction Therapy: What Quantitative Computed Tomography Parameters Matter?
Authors: Theilig Dorothea , Huebner Ralf-Harto , Neumann Konrad , Poellinger Alexander , Doellinger Felix 
Published: October 2018

Purpose Evaluation of emphysema distribution with quantitative computed tomography (qCT) prior to endoscopic lung volume reduction (ELVR) is recommended. The aim of this study was to determine which of the commonly assessed qCT parameters prior to endoscopic lung volume reduction (ELVR) best predicts outcome of treatment.
Materials and Methods 50 patients who underwent technically successful ELVR at our institution were retrospectively analyzed. We performed quantitative analysis of the CT scans obtained prior to ELVR and carried out Mann-Whitney U-tests and a logistic regression analysis to identify the qCT parameters that predict successful outcome of ELVR in terms of improved forced expiratory volume in 1 second (FEV1).
Results In the Mann-Whitney U-test, the interlobar emphysema heterogeneity index (p = 0.008) and the pulmonary emphysema score (p = 0.022) showed a statistically significant difference between responders and non-responders. In multiple logistic regression analysis only the interlobar emphysema heterogeneity index (p = 0.008) showed a statistically significant impact on the outcome of ELVR, while targeted lobe volume, total lung volume, targeted lobe emphysema score and total lung emphysema score did not.
Conclusion Of all commonly assessed quantitative CT parameters, only the heterogeneity index definitely allows prediction of ELVR outcome in patients with advanced chronic obstructive pulmonary disease (COPD).
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Chroniker und Metallbelastungen aus der Mundhöhle
Authors: Klehmet Martin F.H.K. 
Published: October 2018

ZusammenfassungInsbesondere bei chronisch Erkrankten ist die Möglichkeit einer sich pathologisch auswirkenden Metallbelastung aus der Mundhöhle gegeben. Diese sind toxikologisch und mittels Immundiagnostik zu untersuchen. In der Therapie gilt es, den Körper von den Belastungen zu befreien. Hierfür sind die Chelat- und Orthomolekulartherapie empfehlenswert.
Hearing Rehabilitation through Bone-Conducted Sound Stimulation: Preliminary Results
Authors: Bahmad Jr Fayez , Cardoso Carolina , Caldas Fernanda , Barreto Monique , Hilgenberg Anacléia , Teixeira Marina , Serra Lucieny 
Published: October 2018

Introduction The bone-anchored hearing aid (BAHA) is a bone conduction system that transmits the sound directly to the inner ear by surpassing the skin impedance and the subcutaneous tissue. It is indicated for patients with mixed, conductive and unilateral sensorineural hearing loss who did not benefit from conventional hearing aids (HAs). Although the benefits from BAHA are well demonstrated internationally, this field still lacks studies in Brazil.
Objective To assess the auditory rehabilitation process in BAHA users through audiological, speech perception and tinnitus aspects.
Methods Individuals with hearing loss were assessed before and after the implantation. The participants were subjected to pure tone audiometry in free field, functional gain audiometry, speech perception tests, tinnitus handicap inventory (THI) in open format, and to the visual analog scale (VAS).
Results It was found that the participants benefited from the use of BAHA. The difference in the performance of the participants before and after the BAHA surgery was significant in terms of hearing acuity. There was no statistically significant difference in the speech perception tests. The tinnitus assessment showed that 80% of the participants scored slight tinnitus severity in THI after using a BAHA. Eighty percent of the participants classified their tinnitus as absent to mild in the VAS after the surgery.
Conclusion Based on the results of the current study, we can conclude that the participants improved both the auditory perception and the tinnitus handicap.
Endoscopic Endonasal Approach to Foramen Magnum Meningioma—Technical Note and Case Example
Authors: Romero Flavio , Vieira Rodolfo , Ancheschi Bruno 
Published: October 2018

AbstractForamen magnum (FM) tumors represent one of the most complex cases for the neurosurgeon, due to their location in a very anatomically complex region surrounded by the brainstem and the lower cranial nerves, by bony elements of the craniocervical junction, and by the vertebrobasilar vessels. Currently, the open approach of choice is a lateral extension of the posterior midline approach including far lateral, and extreme lateral routes. However, the transoraltranspharyngeal approach remains the treatment of choice in cases of diseases affecting the craniocervical junction. For very selective cases, the endoscopic endonasal route to this region is another option. We present a case of a ventral FM meningioma treated exclusively with the endoscopic endonasal approach.
Radiation-Induced Uterine Carcinosarcoma after Concurrent Chemoradiotherapy for Cervical Squamous Cell Carcinoma
Authors: Moreira-Barros Joana , Huang Kuan-Gen , Tsai Tsung-Hsun 
Published: October 2018

Objective To describe a case of radiation-induced uterine carcinosarcoma 6 years after a cervical squamous cell carcinoma treatment, which imposed some diagnostic and management challenges.
Case Report A 57-year-old woman with a history of pelvic chemoradiotherapy ∼ 6.5 years before the event described in this study, following an International Federation of Gynecology and Obstetrics (FIGO) stage IIB cervical cancer, presented with a cervical mass, involving the uterine cavity, the cervical canal and the upper two thirds of the vagina. The biopsy showed a poorly differentiated carcinoma, and a positron emission tomography (PET) scan excluded distant metastasis, although it was unable to define the origin of the tumor as either a new primary malignancy of the endometrium/cervix or as a cervical recurrence. Surgical staging procedure was performed, and the diagnosis was endometrial carcinosarcoma, FIGO stage IIB. The patient was not able to complete the adjuvant therapy, and the progression of the disease was remarkable.
Conclusion The present case highlights one of the less common but more serious consequences of radiotherapy for cervical cancer, which has an increasing incidence in younger women, raising concerns about the long-term consequences of its management.
Schadstoffe als Ursache oder Auslöser endokriner Störungen und chronischer Erkrankungen
Authors: Schulte-Uebbing Claus , Landenberger Martin , Pfab Florian , Antal Liana 
Published: October 2018

ZusammenfassungPestizide, Schwermetalle, Weichmacher, Schadstoffe aus dem Tabakrauch und andere Substanzen wirken als Endokrine Disruptoren und können chronische Erkankungen und Tumorwachstum fördern sowie Alterungsprozesse von Geweben beschleunigen. Aminosäuren sind in der Lage, neoplastischen Prozessen entgegenzuwirken, beeinflussen neurochemische Resilienzfaktoren und ZNS-Faktoren positiv, beugen Insulinresistenz und damit Diabetes vor. Auch für die Detoxifikation eliminationspflichtiger lipophiler Substrate ist die ausreichende Versorgung mit Aminosäuren notwendig. Endokrine Disruptoren können immunologische und neurologische Regelkreise stören, den Aminosäurestoffwechsel empfindlich beeinträchtigen und zu einem deutlich erhöhten Bedarf an Aminosäuren führen. Eine gezielte individuelle laborkontrollierte Aminosäurezufuhr kann ein effektives therapeutisches Element in der angewandten Präventivmedizin sein.
MiR-1204 promotes ovarian squamous cell carcinoma growth by increasing glucose uptake
Authors: Xu Jia , Gu XiaoLi , Yang Xiaozhuo , Meng Yuejin 
Published: October 2018

ABSTRACT
MiR-1204 has been recently identified as an oncogenic miRNA in breast cancer. Our study aims to investigate the role of miR-1204 in ovarian squamous cell carcinoma. Expression of miR-1204 and glucose transporter 1 in ovarian biopsies and plasma of both OC patients and healthy controls was detected by qRT-PCR. Correlations between patients’ clinicopathological data were analyzed by Chi-square test. MiR-1204 overexpression OC cell lines were established. Expression of GLUT-1 protein was detected by western blot. Glucose uptake was measured by glucose uptake assay. Cell proliferation was detected by CCK-8 assay. We found that miR-1204 expression was significantly correlated with tumor size. Expression levels of miR-1204 and GLUT-1 were significantly high in OC patients. Expression levels of miR-1204 were positively correlated with expression levels of GLUT-1 in OC patients. MiR-1204 overexpression significantly promoted GLUT-1 expression, glucose uptake and cell proliferation. MiR-1204 may promote ovarian squamous cell carcinoma growth by increasing glucose uptake.
Silencing of cyt-c4 led to decrease of biofilm formation in Aeromonas hydrophila
Authors: Li Huiyao , Qin Yingxue , Mao Xiuxiu , Zheng Wanmei , Luo Gang , Xu Xiaojin , Zheng Jiang 
Published: October 2018

ABSTRACT
Aquaculture suffers from a number of diseases caused by Aeromonas hydrophila. Biofilm can protect bacteria from antibiotic therapy. To identify the genes those play crucial roles in A. hydrophila biofilm formation, a library of mini-Tn10 transposon insertion mutants of A. hydrophila B11 has been constructed, and 10 mutants were subjected to biofilm formation assay. The biofilm formation ability of mutant (B188) was significantly decreased compared with B11. The DNA sequence flanking the mini-Tn10 transposon inserted showed that an ORF of approximately 576 bp of the mutant strain B188 was inserted. This ORF putatively displays the highest identity (92%) with the cytochrome c4 gene (cyt-c4) of A. hydrophila subsp. hydrophila ATCC 7966. Silencing cyt-c4 led to deficiencies in biofilm formation, adhesion, drug resistance and pathogenicity of A. hydrophila, which suggests that cyt-c4 plays crucial role in the biofilm formation and virulence mechanisms of A. hydrophila.
ABBREVIATIONS: GEN: gentamycin; SDZ: sulfadiazine; AK: amikacin; P: penicillin; CFP: cefoperazone; LEV: levofloxacin; MH: minocycline; FFC: florfenicol; TE: tetracycline; AMP: ampicillin; KAN: kanamycin; STR: streptomycin; SXT: sulfamethoxazole/trimethoprim; DO: doxycycline; OT: Oxytetracycline.
DREADD technology reveals major impact of Gq signalling on cardiac electrophysiology
Authors: Kaiser Elisabeth , Tian Qinghai , Wagner Michael , Barth Monika , Xian Wenying , Schröder Laura , Ruppenthal Sandra , Kaestner Lars , Boehm Ulrich , Wartenberg Philipp , Lu Huiyan , McMillin Sara M , Bone Derek B J , Wess Jürgen , Lipp Peter 
Published: October 2018

Abstract

Aims
Signalling via Gq-coupled receptors is of profound importance in many cardiac diseases such as hypertrophy and arrhythmia. Nevertheless, owing to their widespread expression and the inability to selectively stimulate such receptors in vivo, their relevance for cardiac function is not well understood. We here use DREADD technology to understand the role of Gq-coupled signalling in vivo in cardiac function.

Methods and results
We generated a novel transgenic mouse line that expresses a Gq-coupled DREADD (Dq) in striated muscle under the control of the muscle creatine kinase promotor. In vivo injection of the DREADD agonist clozapine-N-oxide (CNO) resulted in a dose-dependent, rapid mortality of the animals. In vivo electrocardiogram data revealed severe cardiac arrhythmias including lack of P waves, atrioventricular block, and ventricular tachycardia. Following Dq activation, electrophysiological malfunction of the heart could be recapitulated in the isolated heart ex vivo. Individual ventricular and atrial myocytes displayed a positive inotropic response and arrhythmogenic events in the absence of altered action potentials. Ventricular tissue sections revealed a strong co-localization of Dq with the principal cardiac connexin CX43. Western blot analysis with phosphor-specific antibodies revealed strong phosphorylation of a PKC-dependent CX43 phosphorylation site following CNO application in vivo.

Conclusion
Activation of Gq-coupled signalling has a major impact on impulse generation, impulse propagation, and coordinated impulse delivery in the heart. Thus, Gq-coupled signalling does not only modulate the myocytes’ Ca2+ handling but also directly alters the heart’s electrophysiological properties such as intercellular communication. This study greatly advances our understanding of the plethora of modulatory influences of Gq signalling on the heart in vivo.
A dearth of atomic hydrogen in NGC 1052-DF2
Authors: Chowdhury Aditya 
Published: October 2018

ABSTRACT
The recently claimed discovery of an ultra-diffuse galaxy lacking dark matter has important implications for alternate theories to dark matter as well as models of galaxy formation in the lambda cold dark matter context. In this letter, we present a deep Giant Metrewave Radio Telescope search for atomic hydrogen in this ultra-diffuse galaxy, NGC 1052-DF2. We report a non-detection of the H i 21cm transition from the galaxy and place a stringent upper limit on the H i  mass of the galaxy – $\rm{M}_{\rm H\, {\small {I}}} \lt 3.15 \times 10^6 \ ({\Delta V}/20 \ \rm{km/s})^{1/2} \ \rm{M}_\odot \ (3\sigma)$. This makes NGC 1052-DF2 an extremely gas-poor galaxy with an atomic gas to stellar mass fraction of $\rm{M}_{\rm H\, {\small {I}}}/\rm{M}_* \ \lt \ 0.016 \ ({\Delta V}/20 \ \rm{km/s})^{1/2} \ (3\sigma)$. Such low gas fractions are typical of dwarf ellipticals in dense environments and would be consistent with NGC 1052-DF2 having undergone a tidal stripping event which can also explain its apparent lack of dark matter.
Associations between multipollutant day types and select cardiorespiratory outcomes in Columbia, South Carolina, 2002 to 2013
Authors: Pearce John L. , Neelon Brian , Bozigar Matthew , Hunt Kelly J. , Commodore Adwoa , Vena John 
Published: October 2018

Background:
Health studies of air pollution are increasingly aiming to study associations between air pollutant mixtures and health.

Objective:
Estimate associations between observed combinations of ambient air pollutants and select cardiorespiratory outcomes in Columbia, South Carolina, during 2002 to 2013.

Methods:
We estimate associations using a two-stage approach. First, we identified a collection of observed pollutant combinations, which we define as multipollutant day types (MDTs), by applying a self-organizing map to daily measures of nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and particulate matter ≤2.5 μm (PM2.5). Then, overdispersed Poisson time-series models were used to estimate associations between MDTs and each outcome using a “clean” MDT referent and controlling for long-term, seasonal, and day-of-the-week trends and meteorology. Outcomes included daily emergency department visits for asthma and upper respiratory infection (URI) and hospital admissions for congestive heart failure (CHF) and ischemic heart disease (IHD).

Results:
We found that a number of MDTs were significantly and positively associated (point estimates ranged from ≈2% to 5%) with cardiorespiratory outcomes in Columbia when compared to days with low pollution. Estimated associations revealed that outcomes for asthma, URIs, and IHD increased 2–4% on warm, dry days experiencing elevated levels of O3 and PM2.5. We also found that cooler days with higher NO2 pollution associated with increased asthma, CHF, and IHD outcomes (2–5%).

Conclusion:
Our analysis continues support for using self-organizing maps to develop multipollutant exposure metrics and further illustrates how such metrics can be applied to explore associations between pertinent pollutant combinations and health.
Quality Improvement Program Outcomes for Endotracheal Intubation in the Emergency Department
Authors: Hwang Sung Yeon , Park Joo Hyun , Yoon Hee , Cha Won Chul , Jo Ik Joon , Sim Min Seob , Song Keun Jeong , Woo Hyo Jung , Jeong Sung Geun , Shin Tae Gun 
Published: October 2018

Objectives
We describe our 3-year experience with endotracheal intubation (ETI) outcomes during a multidisciplinary emergency department (ED)-based quality improvement (QI) program.

Methods
This was a single-center, observational study taking place during a QI program. We used a registry for airway management performed in the ED from April 2014 to February 2017. The QI program focused on procedural standardization, airway management education, and comprehensive preparation of airway equipment. The primary outcome was first-pass success (FPS) rate. The secondary outcomes were multiple-attempts rate and overall rate of complications.

Results
A total of 1087 emergent ETIs were included. The FPS rate significantly increased from 68% in the first year to 74% in the second year and 79% in the third year (P for trend <0.01). The multiple-attempts rate in the first year was 12%, followed by 7% and 6% in the second and third years, respectively (P for trend <0.01). The overall complication rate was 16% in the first year, 8% in the second year, and 8% in the third year (P for trend <0.01).

Conclusions
We observed improved ETI outcomes in the ED, including increased FPS rate and decrease in multiple-attempt rate and overall complication rate during the multidisciplinary QI program to enhance patient safety.