bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technical Note: The design, construction, and evaluation of a liquid‐based single phantom solution for TG128 brachytherapy ultrasound QA
Authors: Leong Brian , Ostyn Mark , Oh Seungjong , Kim Siyong 
Published: November 2018

PurposeSince the publication of the AAPM TG128 report for the quality assurance (QA) of prostate brachytherapy ultrasound systems, no commercially available phantoms have been developed which satisfy all of the task group recommendations. Current solid phantoms require a separate user‐implemented setup using a container with liquid medium to evaluate the alignment between the needle template and the electronic grid, a test of geometric accuracy with critical implications in dosimetric quality. Utilizing a 3D printer, we constructed a cost‐effective, liquid‐based phantom that provides a complete TG128 solution which improves the efficiency of brachytherapy ultrasound QA.MethodsThe TG128 report was used to guide the design process of the liquid‐based phantom. The needle template and electronic grid alignment setup served as the foundation with specific components developed to integrate all remaining tests. Water was chosen as the liquid medium, with speed of sound adjusted to 1,540 m/s via salinity per the task group recommendations. The proof of concept was evaluated by comparing the time stamps labeled on QA images between the liquid‐based phantom and a commercially available one for both a new and experienced user.ResultsA TG128 QA trial run demonstrated that all recommended tests can be completed with the single phantom setup. Evaluation of the time data revealed a total QA duration of 45 min (average of two trials) with the liquid‐based phantom, compared to 70 and 90 min with the commercial phantom for a new and experienced user.ConclusionsThe liquid‐based phantom is specifically designed to satisfy the recommendations of the TG128 report. The incorporation of 3D printing allows simple design modifications to adapt the phantom on‐the‐fly if needed. The resulting product improves the efficiency of brachytherapy ultrasound QA by eliminating the need for multiple phantom setups.
Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase‐2
Authors: Koshimizu Hisatsugu , Hirata Nao , Takao Keizo , Toyama Keiko , Ichinose Takashi , Furuya Shigeki , Miyakawa Tsuyoshi 
Published: November 2018

AbstractAimTryptophan hydroxylase 2 (Tph2) is a rate‐limiting enzyme for the biosynthesis of 5‐hydroxytryptamine (5‐HT, serotonin). Previous studies have reported that C1473G polymorphism of the murine Tph2 gene leads to decreased 5‐HT levels in the brain and abnormal behavioral phenotypes, such as impaired anxiety‐ and depression‐like behaviors. In this study, to confirm the effect of the C1473G polymorphism on mouse phenotypes, we conducted a comprehensive battery of behavioral tests and measured the amounts of brain free amino acids involved in the production of 5‐HT.MethodsWe obtained C57BL/6J congenic mice that were homozygous for the 1473G allele of Tph2 (1473G) and subjected them and their wild‐type littermates (1473C) to a battery of behavioral tests. Using reverse‐phase high‐performance liquid chromatography (HPLC), we measured the amounts of free amino acids in the 5‐HT and epinephrine synthetic/metabolic pathways in the frontal cortex, hippocampus, striatum, and midbrain.ResultsWe failed to detect significant differences between genotypes in depression‐like behaviors, anxiety‐like behaviors, social behaviors, sensorimotor gaiting, or learning and memory, while 1473G mice exhibited a nominally significant impairment in gait analysis, which failed to reach study‐wide significance. In the HPLC analysis, there were no significant differences in the amounts of 5‐HT, dopamine, norepinephrine, and epinephrine in the frontal cortex, hippocampus, striatum, and midbrain.ConclusionOur findings do not support the idea that congenic C57BL/6J mice carrying the 1473G allele may represent an animal model of mood disorder under normal conditions without stress.
Understanding IPL boundaries
Authors: Dowell Art M. 
Published: November 2018

Layer of protection analysis (LOPA) is a simplified risk assessment tool that has been in use for almost three decades. The technique has improved the focus on independent protection layers (IPLs) that can prevent the progression of an initiating cause to an undesired consequence (a scenario). An IPL must be capable of preventing the scenario from reaching the consequence. To execute the simplified LOPA approach, the IPL must be independent of the initiating cause and other IPLs.A potential pitfall in LOPA and in the management of IPLs identified in LOPA is misunderstanding the boundary of the IPL.For example, a pressure relief valve (PRV) is intended as an IPL to prevent the consequence of catastrophic rupture of the vessel with potential for fatality. In reality, for the PRV to prevent vessel rupture, the inlet piping from the vessel to the relief valve and the outlet piping from the relief valve to the ultimate destination must provide sufficient flow capability. The IPL boundary must include any block valves in the inlet and outlet piping, and any devices such as flame arrestors or back pressure controllers. The probability of failure on demand (PFD) must include everything in the expanded IPL boundary.If the IPL boundaries are not correctly understood, the LOPA is not correct and the organization is deluding itself on the risk reduction.In addition to being independent and effective in preventing the consequence, an IPL must also be auditable. If an IPL boundary does not include all the components to make the IPL effective, the audit (inspection and testing) program will be incomplete. The PFD of the excluded—but needed—components will be higher than the PFD of the same components that are audited. Narrow IPL boundaries give two problems in calculating the correct PFD: (1) Needed components are not included in the PFD calculation, and (2) The actual PFD of excluded components is higher than it would be if the components were inspected.The article provides examples and illustrations for several types of IPLs: safety instrumented functions, dikes, relief device with fire‐resistant insulation and cladding on the vessel, operator response to alarm, and deflagration arrester. The article includes diagrams to illustrate the concepts. © 2018 American Institute of Chemical Engineers Process Saf Prog 38: e12019, 2019
The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines
Authors: Kucinska Malgorzata , Mieszczak Helena , Piotrowska-Kempisty Hanna , Kaczmarek Mariusz , Granig Walter , Murias Marek , Erker Thomas 
Published: November 2018

Summary
It has been shown previously that molecules built on benzanilide and thiobenzanilide scaffolds possess differential biological properties including selective anticancer activity. In our previous study, we examined the cytotoxic activity and mechanism of action of the thiobenzanilide derivative N,N′-(1,2-phenylene)bis3,4,5–trifluorobenzothioamide (63 T) as a potential chemotherapeutic compound in an experimental model employing A549 lung adenocarcinoma cells and CCD39Lu non-tumorigenic lung fibroblasts. Since the results suggested oxidative stress as a co-existing mechanism of the cytotoxic effect exerted by 63 T on tested cells, studies involving the analysis of reactive oxygen species (ROS) generation and markers of oxidative stress in cells incubated with 63 T were carried out. It may be concluded that the selective activity of 63 T against cancer cells shown in our experiments is caused, at least in part, by the response of the tested cells to 63 T mediated oxidative stress in both tested cell lines.
Barriers, Facilitators and Interventions to Support Virtual Reality Implementation in Rehabilitation: A Scoping Review
Authors: Glegg Stephanie Miranda Nadine , Levac Danielle Elaine 
Published: November 2018

AbstractVirtual reality and active video games (VR/AVGs) are promising rehabilitation tools because of their potential to facilitate abundant, motivating, and feedback‐rich practice. However, clinical adoption remains low despite a growing evidence base and the recent development of clinically accessible and rehabilitation‐specific VR/AVG systems. Given clinicians’ eagerness for resources to support VR/AVG use, a critical need exists for knowledge translation (KT) interventions to facilitate VR/AVG integration into clinical practice. KT interventions have the potential to support adoption by targeting known barriers to, and facilitators of, change. This scoping review of the VR/AVG literature uses the Theoretical Domains Framework (TDF) to (1) structure an overview of known barriers and facilitators to clinical uptake of VR/AVGs for rehabilitation; (2) identify KT strategies to target these factors to facilitate adoption; and (3) report the results of these strategies. Barriers/facilitators and evaluated or proposed KT interventions spanned all but 1 and 2 TDF domains, respectively. Most frequently cited barriers/facilitators were found in the TDF domains of Knowledge, Skills, Beliefs About Capabilities, Beliefs About Consequences, Intentions, Goals, Environmental Context and Resources, and Social Influences. Few studies empirically evaluated KT interventions to support adoption; measured change in VR/AVG use did not accompany improvements in self‐reported skills, attitudes, and knowledge. Recommendations to target frequently identified barriers include technology development to meet end‐user needs more effectively, competency development for end‐users, and facilitated VR/AVG implementation in clinical settings. Subsequent research can address knowledge gaps in both clinical and VR/AVG implementation research, including on KT intervention effectiveness and unexamined TDF domain barriers.Level of EvidenceIV
Non-linear glacier response to calving events, Jakobshavn Isbræ, Greenland
Authors: CASSOTTO RYAN , FAHNESTOCK MARK , AMUNDSON JASON M. , TRUFFER MARTIN , BOETTCHER MARGARET S. , DE LA PEÑA SANTIAGO , HOWAT IAN 
Published: November 2018

ABSTRACTJakobshavn Isbræ, a tidewater glacier that produces some of Greenland's largest icebergs and highest speeds, reached record-high flow rates in 2012 (Joughin and others, 2014). We use terrestrial radar interferometric observations from August 2012 to characterize the events that led to record-high flow. We find that the highest speeds occurred in response to a small calving retreat, while several larger calving events produced negligible changes in glacier speed. This non-linear response to calving events suggests the terminus was close to flotation and therefore highly sensitive to terminus position. Our observations indicate that a glacier's response to calving is a consequence of two competing feedbacks: (1) an increase in strain rates that leads to dynamic thinning and faster flow, thereby promoting destabilization, and (2) an increase in flow rates that advects thick ice toward the terminus and promotes restabilization. The competition between these feedbacks depends on temporal and spatial variations in the glacier's proximity to flotation. This study highlights the importance of dynamic thinning and advective processes on tidewater glacier stability, and further suggests the latter may be limiting the current retreat due to the thick ice that occupies Jakobshavn Isbræ’s retrograde bed.
Modeling the Near‐Surface Diurnal Cycle of Sea Surface Temperature in the Mediterranean Sea
Authors: Pimentel S. , Tse W.‐H. , Xu H. , Denaxa D. , Jansen E. , Korres G. , Mirouze I. , Storto A. 
Published: November 2018

AbstractThe diurnal cycle of sea surface temperature (SST) is an important component of the ocean‐atmosphere system and is necessary for accurately computing air‐sea heat fluxes. Ocean temperatures in the near‐surface are highly sensitive to atmospheric conditions and can vary significantly depending on time of day. Ocean general circulation models are unable to fully capture the near‐surface diurnal SST variability, because they do not possess the necessary vertical structure and resolution. Furthermore, SST observations come from a number of sources that represent the temperature at various near‐surface depths. This presents difficulties when assimilating SST observations as well as constructing robust climate records of SST. In this study we model the fine‐scale near‐surface structure allowing SST comparisons between foundation SST, SST at depth, subskin SST, and skin SST. Hourly model results, forced and initialized using readily available reanalysis data, are from a 2‐year period, 2013–2014, over the Mediterranean Sea. Various solar absorption parameterizations are examined, and the resulting SSTs are compared to Spinning Enhanced Visible and InfraRed Imager‐derived observations of the skin temperature.
New Detrital Zircon Geochronology From the Cycladic Basement (Greece): Implications for the Paleozoic Accretion of Peri‐Gondwanan Terranes to Laurussia
Authors: Zlatkin Olga , Avigad Dov , Gerdes Axel 
Published: November 2018

AbstractBetween the eastern Mediterranean basin in the South and the East European (Baltica) Craton to the north, we distinguish two fundamental pre‐Variscan geological domains: an Internal domain, which hosts Ordovician‐Devonian (450–400 Ma) igneous rocks and detrital zircon populations, and an External domain, which contains no 450‐ to 400‐Ma zircon ages. From the Balkan Peninsula to the Turkish plate, the aforementioned Internal domain includes the Serbo‐Macedonian Massif, the Istanbul and Sakarya terranes, whereas the External domain, holding a more distal position relative to Baltica, includes the Pelagonian terrane and the External Hellenides. The two domains are interpreted as two consecutive (i.e., Caledonian and Variscan) Paleozoic accretionary belts, attached to the southern margin of Baltica. The Cycladic and Pelagonian terranes are currently juxtaposed along strike of the central Hellenides in Northern Greece. The Cycladic Massif is a Cadomian‐type terrane, while the Pelagonian displays an Avalonian‐type affinity. Despite its Avalonian affinity, the Pelagonian lacks Ordovician‐Devonian (450–400‐Ma) zircon ages. In contrast, detrital zircon grains of such ages are abundant in the Cycladic Massif. In this study, the Ordovician‐Devonian detrital zircon population is recognized also in pre‐Variscan (>310‐Ma) Cycladic Basement from Ios and Naxos Islands, affiliating the Cycladic Massif with the Internal (Caledonian) domain. This indicates that the Caledonian accretion incorporated some Cadomian‐type terranes. It also suggests that the protolith of the Cycladic blueschists was deposited within the Internal domain, that is, northeast of the Pelagonian terrane. This recognition helps to reconstruct the Paleozoic and Mesozoic paleogeography of the peri‐Gondwanan terranes.
Kinematics of Foreland‐Vergent Crustal Accretion: Inferences From the Dinarides Evolution
Authors: van Unen Marianne , Matenco Liviu , Nader Fadi Henri , Darnault Romain , Mandic Oleg , Demir Vedad 
Published: November 2018

AbstractOne of the most common observation in Mediterranean areas is the migration of contractional deformation and associated slabs through time toward external orogenic areas, associated with lower plate crustal accretion. The Dinarides orogen of Central Europe is an optimal place to study such a sequence of contractional deformation. Compared with other areas, contraction in the Dinarides was less overprinted by subsequent extension, while a remnant of the subducted slab is observed in a far external orogenic position. Understanding the deformational evolution of the Dinarides is hampered by the reduced availability of kinematic studies. Therefore, we have performed a surface kinematic study in the external parts of the Dinarides. By correlating with available geophysical and evolutionary constraints, we constructed two large‐scale, kinematically controlled regional transects. The results demonstrate a long‐lived evolution of shortening that affected the Dinarides lower orogenic plate. While the Late Jurassic‐earliest Cretaceous deformation was associated with an earlier obduction moment, the latest Cretaceous onset of continental collision has gradually focused deformation at inherited rheological weakness zones. We show that shortening was interrupted by a period of Miocene extension that affected all orogenic areas and created the Dinarides Lake System. The extension was followed by renewed shortening, which started during the latest Miocene and remains presently active, whose kinematics in the central and SE part of the Dinarides is revealed for the first time by our study. These results indicate a lower plate crustal accretion mechanism that was spatially and temporally connected with gradual slab retreat in the Dinarides.
Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study
Authors: Siemer Svenja , Hahlbrock Angelina , Vallet Cecilia , McClements David Julian , Balszuweit Jan , Voskuhl Jens , Docter Dominic , Wessler Silja , Knauer Shirley K. , Westmeier Dana , Stauber Roland H. 
Published: November 2018

AbstractNanotechnology provides the food industry with new ways to modulate various aspects of food. Hence, engineered nanoparticles (NPs) are increasingly added to food and beverage products as functional ingredients. However, the impact of engineered as well as naturally occurring NPs on both commensal and pathogenic microorganisms within the gastrointestinal tract (GI) is not fully understood. Here, well-defined synthetic NPs and bacterial models were used to probe nanoparticle–bacteria interactions, from analytical to in situ to in vitro. NP–bacteria complexation occurred most efficiently for small NPs, independent of their core material or surface charge, but could be reduced by NPs’ steric surface modifications. Adsorption to bacteria could also be demonstrated for naturally occurring carbon NPs isolated from beer. Complex formation affected the (patho)biological behavior of both the NPs and bacteria, including their cellular uptake into epithelial cells and phagocytes, pathogenic signaling pathways, and NP-induced cell toxicity. NP–bacteria complex formation was concentration-dependently reduced when the NPs became coated with biomolecule coronas with sequential simulation of first oral uptake and then the GI. However, efficient NP adsorption was restored when the pH was sufficiently low, such as in simulating the conditions of the stomach. Collectively, NP binding to enteric bacteria may impact their (patho)biology, particularly in the stomach. Nanosized-food additives as well as naturally occurring NPs may be exploited to (rationally) shape the microbiome. The information contained in this article should facilitate a “safe by design” strategy for the development and application of engineered NPs as functional foods ingredients.
Measurement-Device-Independent Quantum Key Distribution over asymmetric channel and unstable channel
Authors: Hu Xiao-Long , Cao Yuan , Yu Zong-Wen , Wang Xiang-Bin 
Published: November 2018

AbstractWe show that a high key rate of Measurement-Device-Independent Quantum Key Distribution (MDIQKD) over asymmetric and unstable quantum channel can be obtained by full optimization and compensation. Employing a gradient optimization method, we make the full optimization taking both the global optimization for the 12 independent parameters and the joint constraints for statistical fluctuations. We present a loss-compensation method by monitoring the channel loss for an unstable channel. The numerical simulation shows that the method can produce high key rate for both the asymmetric channel and the unstable channel. Compared with the existing results of independent constraints, our result here improves the key rate by 1 to tens of times in typical experimental conditions.
Sodium selenite inhibits deoxynivalenol-induced injury in GPX1-knockdown porcine splenic lymphocytes in culture
Authors: Ren Zhihua , Fan Yu , Zhang Zhuo , Chen Chaoxi , Chen Changhao , Wang Xuemei , Deng Junliang , Peng Guangneng , Hu Yanchun , Cao Suizhong , Yu Shumin , Ma Xiaoping , Shen Liuhong , Zhong Zhijun , Zhou Ziyao , Xu Zhiwen , Zuo Zhicai 
Published: November 2018

AbstractDeoxynivalenol (DON) is a cytotoxic mycotoxin that can cause cell damages. The main effect is to inhibit protein synthesis. Oxidative stress is one of the effects of DON. Selenium (Se) can ameliorate the cell damage caused by DON-induced oxidative stress, but it is unclear whether through selenoprotein glutathione peroxidase 1 (GPX1). We established GPX1-knockdown porcine spleen lymphocytes, and treated them with DON and Se. Untransfected porcine splenic lymphocytes (group P) and transfected cells (group M, GPX1 knockdown) were treated with or without DON (0.824, 0.412, 0.206, or 0.103 μg/mL, group D1-4), Se (Na2SeO3, 2 μM, group Se), or both (group SD1–4) for 6, 12, or 24 h. The cells were collected and the activities of SOD and CAT, levels of GSH, H2O2, malonaldehyde (MDA), total antioxidant capacity (T-AOC), and the inhibition of free hydroxyl radicals were determined. Levels of ROS were measured at 24 h. Compared with group P, the antioxidant capacity of group M was reduced. DON caused greater oxidative damage to the GPX1-knockdown porcine splenic lymphocytes than to the normal control cells. When Na2SeO3 was combined with DON, it reduced the damage in the GPX1-knockdown porcine splenic lymphocytes, but less effectively than in the normal porcine splenic lymphocytes.
Stereochemical conversion of nucleic acid circuits via strand displacement
Authors: Hsieh Wei-Che , Martinez Gustavo R. , Wang Ashley , Wu Sharon F. , Chamdia Raunaq , Ly Danith H. 
Published: November 2018

AbstractRemarkable accomplishments demonstrating the importance of nucleic acids in molecular engineering and computation have been made over the past two decades. However, much of the work in this area so far has been carried out in vitro, utilizing almost exclusively homochiral D-DNAs (or D-RNAs) as chemical building blocks. Such natural building blocks are prone to enzymatic degradation and cross-hybridization with the host’s genetic materials. Here we report the development of an orthogonal nucleic acid system that is made up of a left-handed and a right-handed conformer, and a non-helical peptide nucleic acid analogue. We show that the stereochemical information inherent in the right-handed and left-handed conformers can be interconverted from (R) to (S) and vice versa, along with their helical sense and recognition capability, through strand displacement. The genetic information encoded in these synthetic building blocks can be interfaced with DNA or RNA through a molecular converter.