bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Expression and Transfer of Valence Associated with Social Conformity
Authors: Mistry Prachi , Liljeholm Mimi 
Published: February 2019

AbstractConsensus seeking – abandoning one’s own judgment to align with a group majority – is a fundamental feature of human social interaction. Notably, such striving for majority affiliation often occurs in the absence of any apparent economic or social gain, suggesting that achieving consensus might have intrinsic value. Here, using a simple gambling task, in which the decisions of ostensible previous gamblers were indicated below available options on each trial, we examined the affective properties of agreeing with a group majority by assessing the trade-off between social and non-social currencies, and the transfer of social valence to concomitant stimuli. In spite of demonstrating near-perfect knowledge of objective reward probabilities, participant’s choices and evaluative judgments reflected a reliable preference for conformity, consistent with the hypothesized value of social alignment.
Differing effects of age and starvation on reproductive performance in Drosophila melanogaster
Authors: Churchill Emily R. , Dytham Calvin , Thom Michael D. F. 
Published: February 2019

AbstractSuccessful reproduction requires the completion of many, often condition-dependent, stages, from mate searching and courtship through to sperm transfer, fertilisation and offspring production. Animals can plastically adjust their investment in each stage according to the physical and social environment, their own condition, their future reproductive potential, and the condition of their partner. Here we manipulate age and condition, through a nutritional challenge early or late in life, of both male and female Drosophila melanogaster and measure the effects on courtship, mating, and fitness when paired with a standardized (unmanipulated) partner. Older males were slower to start courting and mating, and courted at a slower rate, but males were indifferent to female age or condition despite older females laying and hatching fewer eggs. Female condition had a substantial effect on mating acceptance rate, which dropped dramatically after starvation, and particularly recent starvation experience. In contrast, male condition had little effect on any of the components of reproductive performance we measured. Intriguingly, we found no evidence for additive or multiplicative effects of ageing and starvation: the only significant interaction between these variables was on male latency to initiate courtship – older males were slower to start courting unless they had experienced starvation early in life. These results indicate that the immediate costs of mating differ between males and females, and that the sexes differ in their perception of the opportunity cost sustained by refusing a mating opportunity. Our results support the idea that ageing has more wide-ranging impact on reproductive behaviours than does nutritional challenge.
Identification of potential plasma biomarkers and metabolic dysfunction for unstable angina pectoris and its complication based on global metabolomics
Authors: Wang Juan , Xu Wenjuan , Zhao Huihui , Chen Jianxin , Zhu Bin , Li Xueli , Deng Dong , Wang Jinping , Liu Junjie , Yu Yingting , Xiao Hongbin , Wang Wei 
Published: February 2019

Abstract
Unstable angina pectoris (UA) is one of the most dangerous clinical symptoms of acute coronary syndrome due to the risk of myocardial ischemia, which can lead to high morbidity and mortality worldwide. Though there are many advantages in understanding the pathophysiology of UA, the identification of biomarkers for the diagnosis, prognosis, and treatment of UA remains a challenge in the clinic. A global metabolomics research based on ultra-performance liquid chromatography (UPLC) combined with Q-TOF/MS was performed to discover the metabolic profile of health controls, UA patients, and UA patients with diabetes mellitus (DM), and screen for potential biomarkers. Twenty-seven potential biomarkers were determined using pattern recognition. These biomarkers, which include free fatty acids, amino acids, lysoPE and lysoPC species, and organic acids, can benefit the clinical diagnosis of UA. Pathway analysis indicated that arginine and proline metabolism, glycerophospholipid metabolism, and purine metabolism were affected in the UA patients, uniquely. Additionally, alterations in the metabolic signatures between UA and UA-complicated DM were also explored. As a result, six differential metabolites with an area under the curve (AUC) of more than 0.85 were identified as biomarkers for the diagnosis of UA and UA complicated with DM. Pathway analysis implied tryptophan metabolism was a key metabolic pathway in UA patients with DM, which provides new insights into the pathological study and drug discovery of UA.
Intraindividual comparison of selective intraarterial
versus systemic intravenous 68Ga-DOTATATE PET/CT in patients with
inoperable meningioma
Authors: Verburg Frederik A. , Wiessmann Martin , Neuloh Georg , Mottaghy Felix M. , Brockmann Marc-Alexander 
Published: February 2019

Abstract
Aim Here we describe the results of superselective intraarterial
application of diagnostic Ga-68-DOTA0,Tyr3-octreotate (Ga-68-DOTATATE) in a
series of patients with inoperable WHO grade II meningiomas which were no longer
amenable to radiotherapy.
Methods Four patients with inoperable WHO grade II meningioma underwent
systemic venous infusion of Ga-68-DOTATATE followed by PET/CT. Ga-68-DOTATATE
application was repeated intraarterially via transfemoral catheterization of
vessels supplying the meningioma and another PET/CT was performed.
Results Selective arterial infusion of Ga-68-DOTATATE increased the median
value for the maximum standardized uptake value (SUV) by 2.6-fold (median
venous: 7.1, median arterial: 21.6; range 2.0–5.0) and the median value for mean
SUV by 2.7-fold (median venous: 4.3, median arterial: 11.2; range 1.6–5.6)
compared to systemic intravenous infusion. Arterial application was well
tolerated by all patients without complications. When compared to liver uptake,
intravenous tracer uptake was insufficient for PRRT, whereas tracer uptake after
superselective intraarterial tracer injection was sufficient to allow for
peptide receptor radionuclide therapy (PRRT) in all patients.
Conclusion Insufficient tracer uptake in meningiomas after intravenous
application of Ga-68-DOTATATE may be safely increased by a factor of 2–5 using
transfemoral selective intraarterial tracer application.
Menière's Disease and Disorders of the Carbohydrate Metabolism Involving the Inner Ear
Authors: Albernaz Pedro L. Mangabeira 
Published: February 2019

Introduction Menière’s disease was described in 1861, but there are still uncertainties regarding its pathophysiology and treatment. Endolymphatic hydrops is recognized as a fundamental pathological characteristic of the disease, as a result of an inadequate absorption of the endolymph. A milder type of endolymphatic hydrops results from an altered chemical composition of the endolymph, due to disorders of the carbohydrate metabolism.
Objective To describe the association of both types of hydrops in patients with Menière disease.
Methods This was a retrospective study of 98 patients with Menière’s disease, 62 of whom also presented disorders of the carbohydrate metabolism, and 5 patients with delayed endolymphatic hydrops, 2 of whom also presented disorders of the carbohydrate metabolism.
Results The follow-up of these patients showed that the correction of the metabolic disorders may help in the clinical treatment of Menière’s disease and of delayed endolymphatic hydrops, but this does not happen in the more severe types of the diseases.
Conclusion Patients with Menière’s disease may present simultaneous disorders of the carbohydrate metabolism, affecting the inner ear. The correction of these disorders helps the clinical treatment but does not preclude the progression of the more severe cases of Menière disease.
Facial Plastic Surgery Faculty Turnover: Survey of Academic Facial Plastic Surgeons and Department Chairs
Authors: Kowalczyk David Michael , Jordan J Randall 
Published: February 2019

Introduction The turnover and inability to consistently retain academic facial plastic surgeons is an issue that many academic departments of otolaryngology face. In addition to the financial costs of staff turnover and gaps in patient care, insufficient exposure of residents to key surgical procedures is a significant problem for residency programs.
Objective To identify the most important reasons that lead faculty members to leave an academic facial plastic surgery (FPS) practice as well as features that may be associated with retention of FPS faculty.
Methods Members of the American Academy of Facial Plastic and Reconstructive Surgery (AAFPRS) and the Association of Academic Departments of Otolaryngology (AADO) were administered an anonymous, online survey. For both groups, we evaluated demographic factors, reasons for choosing academic careers, contributors to faculty turnover, as well as strategies for retention. The frequency of the responses was analyzed.
Results A total of 11.3% (135/1,200) of facial plastic surgery faculty responded to the faculty survey, with 59.1% (68/115) of current, academic surgeons participating, and a total of 16.7% (20/120) of department chairs responded to the chairs' survey. If a faculty member had left/was to leave, more control over practice was the most common reason between the two respondent groups. Of the five most important ways to increase faculty retention, more control over practice was the number one reason.
Conclusion Chairs and facial plastic surgery faculty should strive to agree upon the amount of control over the academic practice to lead to higher retention, better patient care, and continued resident education.
Naturally graded Lie algebras of slow growth
Authors: Millionshchikov D. V. 
Published: February 2019

Abstract
A pro-nilpotent Lie algebra

is said to be naturally graded if it is isomorphic to its associated graded Lie algebra

with respect to the filtration by the ideals in the lower central series. Finite-dimensional naturally graded Lie algebras are known in sub-Riemannian geometry and geometric control theory, where they are called Carnot algebras.
We classify the finite-dimensional and infinite-dimensional naturally graded Lie algebras

with the property

An arbitrary Lie algebra

of this class is generated by the two- dimensional subspace

, and the corresponding growth function

satisfies the bound

.
Bibliography: 32 titles.
Three-dimensional optical trapping and orientation of microparticles for coherent X-ray diffraction imaging
Authors: Gao Yuan , Harder Ross , Southworth Stephen H. , Guest Jeffrey R. , Huang Xiaojing , Yan Zijie , Ocola Leonidas E. , Yifat Yuval , Sule Nishant , Ho Phay J. , Pelton Matthew , Scherer Norbert F. , Young Linda 
Published: February 2019

Significance
Obtaining a fundamental understanding of crystal growth and chemical reactions in solution is of broad and enduring interest for materials discovery, structural biology, and catalysis. The recent availability of bright, coherent X-ray sources can enable these fluctuation-driven processes to be monitored in situ through the technique of coherent X-ray diffractive imaging (CXDI), in which the 3D internal structure of microscopic objects is determined with nanometer resolution from the fine structure of diffraction peaks. So far, Bragg CXDI has required immobilization of particles on a substrate, which modifies their structure and chemical activity. Here, we demonstrate Bragg CXDI on a single particle that is trapped and oriented in solution using optical tweezers and thus obtain its 3D structure and strain map.
Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina
Authors: Nmezi Bruce , Xu Jianquan , Fu Rao , Armiger Travis J. , Rodriguez-Bey Guillermo , Powell Juliana S. , Ma Hongqiang , Sullivan Mara , Tu Yiping , Chen Natalie Y. , Young Stephen G. , Stolz Donna B. , Dahl Kris Noel , Liu Yang , Padiath Quasar S. 
Published: February 2019

Significance
The nuclear lamina is an integral component of all metazoan cells. While the individual constituents of the nuclear lamina, the A- and B-type lamins, have been well studied, whether they exhibit a distinct spatial organization is unclear. Using stochastic optical reconstruction microscopy, we have identified two organizing principles of the nuclear lamina: lamin B1 forms an outer concentric ring, and its localization is curvature-dependent. This suggests that a role of lamin B1 is to stabilize nuclear shape by restraining outward protrusions of the lamin A/C network. These findings provide a model for the nuclear lamina that can predict its behavior and clarify the distinct functional roles for the individual lamina components and the consequences of their perturbation.
Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior
Authors: Soto Marion , Cai Weikang , Konishi Masahiro , Kahn C. Ronald 
Published: February 2019

Significance
Loss of insulin receptors in the brain causes metabolic and behavioral abnormalities whereas loss of IGF-1 receptors in the brain leads to a developmental defect in the brain and periphery. However, less is known about the impact of brain insulin and IGF-1 receptor (IR/IGF1R) loss in adult mice, especially in higher neural processing regions. Here, we show that loss of IR/IGF1R in the hippocampus and central amygdala of adult mice results in decrease in glutamate receptors, accompanied by glucose intolerance, anxiety-like behavior, and impaired cognition. In addition, we identify an insulin/IGF-1 signaling-dependent neural circuit originating from the central amygdala, which regulates interscapular brown fat activity and thermogenesis. Thus, brain insulin/IGF-1 signaling is important for higher neural processing and systemic metabolism.
Self-assembled ruthenium (II) metallacycles and metallacages with imidazole-based ligands and their in vitro anticancer activity
Authors: Zhao Yibo , Zhang Liqian , Li Xu , Shi Yanhui , Ding Ruru , Teng Mengting , Zhang Peng , Cao Changsheng , Stang Peter J. 
Published: February 2019

Significance
Cancer is one of the most deadly diseases. In the treatment of cancer, the success of platinum compounds has propelled the application of transition metal complexes for therapeutic design. Ruthenium compounds have emerged as promising anticancer candidates. Self-assembly strategy allows the construction of large-sized and high-molecular-weight supermolecules that may display antitumor efficacy and selectivity due to their unique biochemical properties. Herein, we describe the construction of Ru(II) tetranuclear rectangular macrocycles and hexanuclear trigonal prisms by self-assembly. The self-assembled compounds containing the 5,8-dioxido-1,4-naphtoquinonato scaffold exhibited enhanced anticancer activity on colon, breast, cervical, lung, and liver cancer cells, and decreased cytotoxicities in HEB and THLE-2 normal cells. Two of these compounds are able to kill cancer cells more effectively and selectively than cisplatin.
Differences in biochemical properties of two 5′-nucleotidases from deep- and shallow-sea Shewanella species under various harsh conditions
Authors: Fujimori Kiko , Fujii Sotaro , Lisdiana Lisa , Wakai Satoshi , Yagi Hisashi , Sambongi Yoshihiro 
Published: February 2019

ABSTRACT
Deep-sea Shewanella violacea 5′-nucleotidase (SVNTase) activity exhibited higher NaCl tolerance than that of a shallow-sea Shewanella amazonensis homologue (SANTase), the sequence identity between them being 70.4%. Here, SVNTase exhibited higher activity than SANTase with various inorganic salts, similar to the difference in their NaCl tolerance. In contrast, SVNTase activity decreased with various organic solvents, while SANTase activity was retained with the same concentrations of the solvents. Therefore, SVNTase is more robust than SANTase with inorganic salts, but more vulnerable with organic solvents. As to protein stability, SANTase was more stable against organic solvents and heat than SVNTase, which correlated with the differences in their enzymatic activities. We also found that SANTase retained higher activity for three weeks than SVNTase did in the presence of glycerol. These findings will facilitate further application of these enzymes as appropriate biological catalysts under various harsh conditions.
Abbreviations: NTase: 5′-nucleotidase; SANTase: Shewanella amazonensis 5′-nucleotidase; SVNTase: Shewanella violacea 5′-nucleotidase; CD: circular dichroism
Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite–host cross talk
Authors: Hansen Eline P. , Fromm Bastian , Andersen Sidsel D. , Marcilla Antonio , Andersen Kasper L. , Borup Anne , Williams Andrew R. , Jex Aaron R. , Gasser Robin B. , Young Neil D. , Hall Ross S. , Stensballe Allan , Ovchinnikov Vladimir , Yan Yan , Fredholm Merete , Thamsborg Stig M. , Nejsum Peter 
Published: February 2019

ABSTRACTThe prevalent porcine helminth, Ascaris suum, compromises pig health and reduces farm productivity worldwide. The closely related human parasite, A. lumbricoides, infects more than 800 million people representing a disease burden of 1.31 million disability‐adjusted life years. The infections are often chronic in nature, and the parasites have a profound ability to modulate their hosts' immune responses. This study provides the first in‐depth characterisation of extracellular vesicles (EVs) from different developmental stages and body parts of A. suum and proposes the role of these vesicles in the host–parasite interplay. The release of EVs from the third‐ (L3) and fourth‐stage (L4) larvae and adults was demonstrated by transmission electron microscopy (TEM), and sequencing of EV‐derived RNA identified a number of microRNAs (miRNAs) and transcripts of potential host immune targets, such as IL‐13, IL‐25 and IL‐33, were identified. Furthermore, proteomics of EVs identified several proteins with immunomodulatory properties and other proteins previously shown to be associated with parasite EVs. Taken together, these results suggest that A. suum EVs and their cargo may play a role in host–parasite interactions. This knowledge may pave the way to novel strategies for helminth infection control and knowledge of their immune modulatory potential.
The First Reported Case of Gluteal Implant-Associated Anaplastic Large Cell Lymphoma (ALCL)
Authors: Shauly Orr , Gould Daniel J , Siddiqi Imran , Patel Ketan M , Carey Joseph 
Published: February 2019

Abstract
Anaplastic large-cell lymphoma (ALCL) is a very rare but life-threatening complication that has largely been demonstrated to be associated with breast implants (BIA-ALCL). Patients are at risk of BIA-ALCL with the placement of breast implants for either cosmetic or reconstructive purposes, with the highest risks associated with textured breast implants. In the past decade, an increasing number of publications have focused on BIA-ALCL, but there has yet to be a reported case outside of the breast. Here, we describe a unique instance of gluteal implant-associated ALCL (GIA-ALCL) in a middle-aged woman. The patient received bilateral textured silicone gluteal implants only a year prior to her diagnosis of GIA-ALCL. The patient later presented to the Plastic and Reconstructive Surgery Department at our institution with ulceration at the site of her gluteal implants. Unfortunately, her condition deteriorated before explanation could be performed. Biopsy of a left lung mass demonstrated “hallmark” cells of ALCL (“horseshoe”-shaped nuclei). The diagnosis was verified by immunohistochemical testing that revealed expression of CD30, CD4, CD43, BCL6, Perforin, and Ki67 in a population of abnormal cells. The goals of this case report are thus to demonstrate that all patients undergoing implantation of textured silicone implants are at risk of developing ALCL and to provide evidence for the possible new diagnosis of GIA-ALCL.
Level of Evidence: 5
Frequency of kdr and kdr-his Alleles in Stable Fly (Diptera: Muscidae) Populations From the United States, Costa Rica, France, and Thailand
Authors: Olafson Pia Untalan , Kaufman Phillip E , Duvallet Gérard , Solórzano José-Arturo , Taylor David B , Fryxell Rebecca Trout 
Published: February 2019

Abstract
Anecdotal evidence of pyrethroid insecticide product failure for the control of stable fly [Stomoxys calcitrans (L.)] populations in the United States and worldwide prompted us to evaluate the frequency of knockdown resistance (kdr)-type polymorphisms within the voltage-sensitive sodium channel (Vssc) gene of field collected specimens from the United States, France, Costa Rica, and Thailand. The kdr-his allele (L1014H), associated with permethrin resistance, was detected in stable flies from the 10 states sampled in the United States, as well as from Costa Rica and France (Toulouse). Field collections of stable flies from California (Modesto) and New York (Cliffton Springs) exhibited reduced susceptibility upon exposure to a diagnostic permethrin concentration of 10× LC99, but survival did not appear to strictly associate with frequency of the kdr-his allele. This suggests that there are additional resistance mechanisms contributing to the phenotype in these states. The kdr allele (L1014F) was detected for the first time in stable flies originating in France and Thailand, and an improved, DNA-based diagnostic assay was developed and validated for use in future screens for kdr and kdr-his allele frequencies from field collections. The absence of kdr in United States and Costa Rica populations suggests that the allele is currently restricted to Europe and Asia.
Comparative Outcomes of Adults Hospitalized With Seasonal Influenza A or B Virus Infection: Application of the 7-Category Ordinal Scale
Authors: Wang Yeming , Fan Guohui , Horby Peter , Hayden Fredrick , Li Qian , Wu Qiaoling , Zou Xiaohui , Li Hui , Zhan Qingyuan , Wang Chen , Cao Bin ,   CAP-China Network
Published: February 2019

Abstract

Background
The objective of this study was to investigate the difference in disease severity between influenza A and B among hospitalized adults using a novel ordinal scale and existing clinical outcome end points.

Methods
A prospective, observational study was conducted over the 2016–2018 influenza seasons in a central hospital. The primary outcome was the rate of clinical improvement, defined as a decline of 2 categories from admission on a 7-category ordinal scale that ranges from 1 (discharged with normal activity) to 7 (death), or hospital discharge up to day 28.

Results
In total, 574 eligible patients were enrolled, including 369 (64.3%) influenza A cases and 205 (35.7%) influenza B cases. The proportion of patients with a worse ordinal scale at admission was higher in influenza A than influenza B (P = .0005). Clinical improvement up to 28 days occurred in 82.4% of patients with influenza A and 90.7% of patients with influenza B (P = .0067). The Cox model indicated that influenza B patients had a higher clinical improvement probability than influenza A cases (adjusted hazard ratio [HR], 1.266; 95% confidence interval [CI], 1.019–1.573; P = .0335). A similar pattern was observed in weaning oxygen supplement (adjusted HR, 1.285; 95% CI, 1.030–1.603; P = .0261). In-hospital mortality for influenza A was marginally higher than influenza B (11.4% vs 6.8%; P = .0782).

Conclusions
Our findings indicated that hospitalized patients with influenza A were more ill and had delayed clinical improvement compared with those with influenza B virus infection.