bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of data quality and associated factors in the routine health information system among health workers in public health institutions of Gofa Zone, Southern Ethiopia: A mixed methods study
Authors: Doka Bedilu Kucho , Worku Abebaw Gebeyehu , Negeri Keneni Gutema , Kassa Dejene Hailu 
Published: November 2024

Background Generating high-quality data at health facilities is fundamental for effective decision making, which helps to strengthen health system performance and promote better health outcomes. Previous studies have revealed inconsistent findings and design-related drawbacks regarding the quality of routine health data. This study, therefore, aimed to assess the level of data quality and associated factors in the routine health information system among health workers in public health institutions of Gofa zone, Southern Ethiopia. Methods An institution-based quantitative cross-sectional study was mixed with a phenomenological qualitative study. Data collection was executed from April 1 to 30, 2023. Samples of 304 health workers were randomly selected. A total of six in-depth interviews and three focus group discussions were also done. Multilevel linear regression and thematic analysis were applied. Results The perceived level of good data quality was 59.5% (95% CI = 53.8, 65.1). The report timeliness, data accuracy, and the data completeness were 53.3%, 89.4%, and 93.5%, respectively. Factors that were significantly associated with data quality include culture of information utilization (β = 0.23, 95% CI = 0.20, 0.40), perceived skill of data management (β = 0.10, 95% CI = 0.03, 0.18), and electric power access (β = 0.11, 95% CI = 0.01, 0.21). The data quality was decreased in health posts by −0.20 (95% CI = −0.371, −0.030). Conclusion The overall quality of routine data among health workers was lower. Improving the skills of data management, cultivating a habit of data use, and enhancing the capacity of health workers are the potential interventions for ensuring data quality in health institutions.
Exploring online health information-seeking behaviour for musculoskeletal pain in Europe: A study protocol combining expert panel insights with search trends on social media and Google
Authors: Cardoso da Silva Lucas , O’Sullivan Kieran , Coyne Lara , Skuli Palsson Thorvaldur , Christensen Steffan Wittrup McPhee , Hoegh Morten , O’Keeffe Mary , Langella Francesco , Blasco-Abadía Julia , Bellosta-Lopéz Pablo , Doménech-García Víctor 
Published: November 2024

IntroductionMusculoskeletal pain is a significant public health concern in Europe. With the advent of the digital age, online health information-seeking behaviour has become increasingly important, influencing health outcomes and the ability of individuals to make well-informed decisions regarding their own well-being or of those they are responsible for. This study protocol outlines an investigation into how individuals in five European countries (Austria, Denmark, Ireland, Italy, and Spain) seek online health information for musculoskeletal pain.MethodsThe protocol adopts an exploratory and systematic two-phase approach to analyse online health information-seeking behaviour. Phase 1 involves four steps: (1) extraction of an extensive list of keywords using Google Ads Keyword Planner; (2) refinement of the list of keywords by an expert panel; (3) investigation of related topics and queries and their degree of association with keywords using Google Trends; and (4) creation of visual representations (word clouds and simplified network graphs) using R. These visual representations provide insights into how individuals search for online health information for musculoskeletal pain. Phase 2 identifies relevant online sources by conducting platform-specific searches on Google, X, Facebook, and Instagram using the refined list of keywords. These sources are then analysed and categorised with NVivo and R to understand the types of information that individuals encounter.ConclusionsThis innovative protocol has significant potential to advance the state-of-the-art in digital health literacy and musculoskeletal pain through a comprehensive understanding of online health information-seeking behaviour. The results may enable the development of effective online health resources and interventions.
Digital coaching and its potential to support the return-to-work-process for individuals with chronic musculoskeletal pain - A focus group study
Authors: Bolic Baric Vedrana , Liedberg Gunilla , Lundell Hanna , Björk Mathilda , Turesson Christina 
Published: November 2024

Background Given the growing digitalization of healthcare and society, it becomes crucial to explore whether digital interactions with healthcare professionals, such as coaching, can offer effective support and contribute to an improved return-to-work process and a sustainable work environment for individuals with chronic musculoskeletal pain. Aim To explore perceptions of digital coaching and its potential to support the return-to-work process for individuals with chronic musculoskeletal pain. Methods Three focus group interviews consisting of 14 people—11 women and three men (with a mean age of 48 years)—were conducted. All participants had a goal of returning to work and had completed an interprofessional rehabilitation program due to chronic musculoskeletal pain. Data were analyzed using thematic analysis. Results Findings show that integrating a coach into digital tools could offer new opportunities for personalized guidance, support and feedback to individuals during the return-to-work process. The first theme emphasizes the importance of sustained support throughout the entire return-to-work process—from rehabilitation programs to workforce integration. The second theme outlines the specific tasks and functions expected from a digital coach, as perceived by the participants. Lastly, the third theme explores the envisioned future evolution of digital coaching in chronic musculoskeletal pain management. Conclusions Digital coaching offers promise in addressing challenges during the return-to-work process, acting as a bridge among stakeholders to ensure accessibility, continuity and coordination in rehabilitation and return-to-work efforts.
Impact of Vascularity on Spinal Disorders Outcomes, Underestimated yet Probably Crucial: The Example of a Comparative Cohort of Epidural Abscesses
Authors: Boukebous Baptiste , Petrie Liam , Baker Joseph F. 
Published: November 2024

Study Design Retrospective comparative cohort. Objective (1) Describe the prevalence of the basivertebral vessel (BVV) in a cohort of spinal epidural abscesses (SEA) at lumbar or thoracic (2) correlate the presence of BVV to the risk of conservative treatment failure (CTF). Methods Twenty-six patients successfully managed without surgery were compared to 26 who required surgical management due to failed conservative management (lumbar and thoracic). Two observers sought the BVV on the sagittal T1 with contrast sequences of the initial MRI in a blinded fashion for Kappa score calculation. BVV-/BVV+: absence/presence. Demographic, radiological, and laboratory parameters, as well as functional scores, were recorded. Results For both observers, 29/52 patients had a BVV+ (55.7%); the agreement was 84% (Kappa: 0.80 CI 95% [0.70-0.90]). 5/23 (21.7%) BVV- patients had a successful medical treatment, while the proportion was 21/29 (72%) for BVV+ ( P = .0003). The positive predictive value for BVV+, predicting successful conservative treatment, was 81%. The negative predictive value for BVV- predicting CTF was 69%. BVV- was predictive of CTF in multivariable logistic regression: OR = 40, CI 95% [5-880], P = .02, for agreed observations between observers. For both observers, the proportion of dorsal abscess was the highest for BVV+ ( P = .01). Conclusion The BVV is part of the epidural network. The absence of BVV was strongly correlated with an increased risk of CTF, leading to the need for subsequent surgical treatment. SEA’s location pattern varied according to BVV detection. Although the spinal vascular anatomy has been well-known for over 100 years, there are still very few studies on its pathophysiological implications.
Comparison of Elbow Flexion in Youth Baseball Pitchers With and Without Throwing-Arm Pain
Authors: Nebel Adam R. , Fava Anthony W. , Bordelon Nicole M. , Oliver Gretchen D. 
Published: November 2024

Background: More than half of all youth baseball pitchers report throwing-related pain in their throwing arm throughout a season. Purpose/Hypothesis: The purpose of this study was to investigate differences in elbow flexion throughout the pitching cycle between youth baseball pitchers with and without throwing-arm pain. It was hypothesized that pitchers with throwing-arm pain would have decreased elbow flexion throughout the pitching cycle compared with those who were pain-free. Study Design: Controlled laboratory study. Methods: A total of 38 youth baseball pitchers (mean age, 13.3 ± 1.7 years; height, 164.4 ± 12.9 cm; weight, 57.1 ± 14 kg) were retrospectively selected from a database. Based on responses to a health history questionnaire, the pitchers were placed into a pain group if they indicated they were experiencing throwing-arm pain. Pitchers who indicated they were not experiencing throwing-arm pain were matched according to age, height, and weight to the pain group. All pitchers threw 3 fastballs to a catcher at the regulation distance. The mean elbow flexion of the 3 trials was used during analysis to investigate peak elbow flexion and time-normalized (0%-100%) elbow flexion across the pitch cycle (stride-foot contact to ball release). Elbow flexion was compared between the pain and pain-free groups using 1-dimensional statistical nonparametric mapping, and the mean peak elbow flexion between groups was compared using the Mann-Whitney U test. Results: No significant differences were observed between the groups in elbow flexion throughout the pitching cycle ( P > .05) and no group differences in peak elbow flexion ( U = 122; P = .09). Conclusion: Study findings indicated no significant differences in elbow flexion between youth baseball pitchers with versus without throwing-arm pain, unlike previous research reporting that pitchers with a history of medial elbow pain had altered elbow flexion and higher pitch velocities compared with those without a history of pain. Clinical Relevance: Clinicians should consider other potential factors related to throwing-arm pain beyond elbow flexion. Moreover, it is advisable to focus on evidence-based modifiable factors shown to increase the risk of pain and injury in youth pitchers, such as exceeding pitch counts, number of innings pitched, increased training time, range-of-motion, and strength deficits.
When Leaders and Followers Match: Unveiling the Nexus Between Despotic Leadership, Supervisor–Employee Value Congruence, and Organizational Deviance—Evidence From Egypt
Authors: Ghanem Atalla Amal Diab , Hafez Duaa , Badr Hanan , Felemban Ohood , Mahsoon Alaa , Mahmoud Elseesy Naglaa Abdelaziz 
Published: November 2024

Introduction Leadership style and employee behavior has long been a topic of interest in organizational research. Objectives To explore levels of despotic leadership, supervisor–employee value congruence, and organizational deviance among the studied nurses. Furthermore, to explore the connection between the three variables. Methods The study employed a cross-sectional quantitative design. The researchers used three tools as follows: the despotic leadership survey, an organizational deviance scale, and a perceived supervisor–employee value congruence scale. The first of April 2023 to the first of July 2023 were the 3 months that were used to collect the data from 250 nurses. The data were analyzed using descriptive statistics, Spearman's correlation, Kruskal–Wallis test, and Mann–Whitney U test. Results Nurses perceived a moderate level of despotic leadership as mean ±  SD, 16.80 ± 3.01, also a moderate level for organizational deviance (30.63 ± 4.65). The studied nurses perceived a moderate level of supervisor–employee value congruence (10.93 ± 1.32) Furthermore, there is a solid positive significant relationship between despotic leadership and organizational deviance where p = .001. There is a negative significant relationship between despotic leadership and supervisor–employee value congruence where p = .001. Also, there is a negative significant relationship between organizational deviance and supervisor–employee value congruence where p = .001. Conclusion Nurse managers need to retain leaders to inspire subordinates’ uncluttered communication networks, stirring nurses’ partaking in nursing committees’ assemblies, and decision-making. Hospital administrators ought to focus more on the role that value congruence plays as a buffer for subordinates who exhibit organizational deviance and high levels of mistrust. Strategies should be employed to create and maintain value congruence and reinforce desired nondeviant behaviors to foster a positive work environment.
An Untethered Soft-Swallowing Robot with Enhanced Heat Resistance, Damage Tolerance, and Impact Mitigation
Authors: Li Haili , Li Xingzhi , Zhou Pan , Yao Jiantao 
Published: November 2024

AbstractSoft robotics focuses on addressing the locomotion problem in unstructured environments and the manipulation problem of non-cooperative objects, which inevitably leads to soft robots encountering multiple uncertainties and damages. Therefore, improving the robustness of soft robots in hostile environmental conditions has always been a challenge. Existing methods usually improve this robustness through damage isolation, material elasticity, and self-healing mechanisms. In contrast to existing methods, this paper proposes a method to improve the robustness of an untethered soft-swallowing robot based on the physical properties of fluids, such as the high specific heat capacity of water, the viscosity of soft glue, and the shear thickening of non-Newtonian fluids. Based on this method, we developed a soft-swallowing robot with enhanced heat resistance, damage tolerance, and impact mitigation capability by only replacing its fluid working medium. Experiments show that the developed soft-swallowing robot can withstand high temperatures above 600 °C, maintain high performance even after enduring hundreds of damages, and protect grasped object from more than 90% of external impacts. This principle extends beyond the three fluids used in this study. Other fluids, such as magnetic fluid, can increase adhesion to metal materials, whereas oily fluids can reduce frictional resistance between soft structures. Additionally, other solid materials with elasticity and compliance can serve as alternative working mediums for the soft-swallowing robot. This work contributes an effective method for fluid-dependent soft robotic systems to resist the damage from uncertain factors in harsh environments.
Antiviral properties and molecular docking studies of eco-friendly biosynthesized copper oxide nanoparticles against alfalfa mosaic virus
Authors: Aseel Dalia G. , Rabie Mona , El-Far Ali , Abdelkhalek Ahmed 
Published: November 2024

Abstract
Background
Nanotechnology has been recognized as a viable technology for enhancing agriculture, particularly in the plant pathogen management area. Alfalfa mosaic virus (AMV) is a global pathogen that affects many plant species, especially economically valuable crops. Currently, there is less data on the interaction of nanoparticles with phytopathogens, particularly viruses. The current study looked into how copper oxide nanoparticles (CuO-NPs)-mediated Haloxylon salicornicum aqueous extract can fight AMV infections on tobacco plants.

Results
Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses showed that CuO-NPs have a spherical and hexagonal structure ranging from 20 to 70 nm in size. Fourier transform infrared spectroscopy (FTIR) analysis showed that the produced CuO-NPs have many functional groups and a lot of secondary plant metabolites. Under greenhouse conditions, the foliar application of CuO-NPs (100 ppm) enhanced tobacco growth and decreased viral symptoms. Treatment with CuO-NPs 48 h before (protective treatment) or 48 h after (curative treatment) AMV infection significantly reduced AMV accumulation levels by 97%. Additionally, the levels of total chlorophyll, phenolic, and flavonoid contents, as well as DPPH, exhibited a significant increase in tobacco leaves 30 days after inoculation in comparison to untreated plants. Moreover, considerable differences in levels of different antioxidant enzymes, including SOD, PPO, POX, and CAT, were also observed. On the other hand, the oxidative stress markers (MDA and H2O2) were significantly reduced in CuO-NPs-treated plants compared with non-treated plants. It was also found that the protective treatment increased the expression levels of genes involved in the jasmonic pathway (JERF3 and WRKY1). On the other hand, the curative treatment increased the expression levels of polyphenolic pathway acid (CHI and HQT) and the SA-signaling pathway genes (PR-2 and POD). The study of molecular docking interactions with four AMV target proteins showed that CuO-NPs had high binding energy with the viral replication protein 1a, measured at -3.2 kcal/mol. The binding with these proteins can suppress AMV replication and spread, potentially clarifying the mechanism behind the antiviral effect.

Conclusions
The overall analysis results indicate that the curative treatment is more influential and successful than the protective treatment in combating AMV infection. Consequentially, CuO-NPs could potentially be employed in foliar sprays for the effective and environmentally friendly management of plant virus infections.
Disruption of the OsWRKY71 transcription factor gene results in early rice seed germination under normal and cold stress conditions
Authors: Bataller Santiago , Davis James A. , Gu Lingkun , Baca Sophia , Chen Gaelan , Majid Azeem , Villacastin Anne J. , Barth Dylan , Han Mira V. , Rushton Paul J. , Shen Qingxi J. 
Published: November 2024

Abstract
Background
Early seed germination in crops can confer a competitive advantage against weeds and reduce the time to maturation and harvest. WRKY transcription factors regulate many aspects of plant development including seed dormancy and germination. Both positive and negative regulators of seed germination have been reported in many plants such as rice and Arabidopsis. Using a transient expression system, we previously demonstrated that OsWRKY71 is a negative regulator of gibberellin (GA) signaling in aleurone cells and likely forms a “repressosome” complex with other transcriptional repressors. Hence, it has the potential to impact seed germination properties.

Results
In this study, we demonstrate that OsWRKY71, a Group IIa WRKY gene, appeared at the same time as seed-bearing plants. Rice mutants lacking OsWRKY71 have seeds and embryos that germinate earlier than wildtype controls. In oswrky71 aleurone layers, α-amylase activity was hypersensitive to stimulation by GA3 and hyposensitive to inhibition by abscisic acid (ABA). Early germination in oswrky71 intact seeds was also hyposensitive to ABA. Transcriptomic profiling during embryo germination and early post-germination growth demonstrates that OsWRKY71 influences the expression of 9–17% of genes in dry and imbibing embryos. Compared to wildtype embryos, the mutant transcriptomes have large temporal shifts at 4, 8 and 12 h after imbibition (HAI). Importantly, many genes involved in the ABA-dependent inhibition of seed germination were downregulated in oswrky71-1. This mutant also displayed altered expression of multiple ABA receptors (OsPYLs/RCARs) that control ABA signaling and the VP1-SDR4-DOG1L branch of ABA signaling that promotes seed dormancy. Association studies reveal an OsWRKY71-containing quantitative trait locus involved in low-temperature seed germinability, qLTG-2. Indeed, oswrky71 seeds germinated early at 15 °C.

Conclusions
Rice Group-IIa WRKY transcription factor OsWRKY71 is a master regulator of germination that influences the expression of 9–17% of genes in dry and imbibing embryos. It is also most likely the primary candidate of low-temperature seed germinability QTL, qLTG-2. We propose that knockouts of OsWRKY71 can generate rice varieties with improved germination properties under normal or low-temperature conditions.
BlephEx-treatment for blepharitis: a prospective randomized placebo-controlled trial
Authors: Siegel Helena , Merz Annika , Gross Nikolai , Bründer Marie-Christine , Böhringer Daniel , Reinhard Thomas , Maier Philip 
Published: November 2024

Abstract
Background
Blepharitis is a chronic inflammatory condition of the eyelids that affects a large proportion of patients in eye care settings. First-line treatments provide only partial relief for many patients. The BlephEx™ device provides automated eyelid debridement and aims to remove pathogenic biofilms from the eyelid margin to treat blepharitis long-term. However, evidence supporting the efficacy of BlephEx™ is limited.

Methods
In this double-masked randomized controlled trial, 42 patients with symptomatic blepharitis refractory to treatment were assigned to the BlephEx™ treatment or sham treatment group. Outcome measures including Ocular surface disease index (OSDI), tear break-up time (TBUT), Schirmer test, and Efron grading scale scores were assessed at baseline and after 4 weeks. A crossover design in which the treatment groups were swapped after 4 weeks was used as a recruitment tool. After receiving treatment, two patients (one per group) were lost to follow-up.

Results
The sham group exhibited a significant decrease in the Efron Grading Scale score. No significant differences were observed in the other outcomes between the two groups. The BlephEx™ group showed slightly greater decreases in the OSDI and Efron grading scale scores and an increase in the TBUT than did the sham group, but these differences were not statistically significant. Mild discomfort was the most common side effect and occurred equally in both groups.

Conclusions
No significant difference in outcomes was observed between patients who underwent BlephEx™ therapy and those who received sham treatment. BlephEx™ treatment cannot be recommended for treating blepharitis.

Trial registration
Retrospectively registered on February 16, 2024 in the DRKS (German Clinical Trials Register under https://drks.de/search/de/trial/DRKS00033492) under the trial registration number DRKS00033492.