bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epitulipinolide diepoxide induces apoptosis in bladder cancer cells by inhibiting the ERK/MAPK signaling pathway and promoting autophagy
Authors: jing zhiqiang , li kai , feng shuang , su hao , yuan dongbo , zhu jianguo 
Published: November 2024

Abstract

Purpse: Epitulipinolide diepoxide has antitumor effects through previous studies, and this paper describes that Epitulipinolide diepoxide inhibits the proliferation of bladder cancer cells and reveals its mechanism.
Methods: Bladder cancer cells (T24) were treated with different concentrations of Epitulipinolide diepoxide, and the IC50 was determined at 24, 48, and 72 h. The proliferation, apoptosis, migration, and invasion activities of the cells were assessed by CCK-8, clone formation, flow cytometry, Transwell, and scratch assay. Cell proliferation, apoptosis, migration, and invasion activities were assessed The Epitulipinolide diepoxide-target-pathway network was investigated by network pharmacology, molecular docking, enrichment analysis, kinetic simulation, and further confirmed by kinetic simulation of Epitulipinolide diepoxide-target binding, and Western blot to evaluate the ERK/MAPK pathway (ERK/PERK/JUK/PAPK) and the protein levels of autophagy markers (LC3/ATG5/P62) were measured by Western blot to evaluate autophagy. Chloroquine (Chq), an autophagy inhibitor, was used to validate the role of autophagy in the mechanisms regulating Epitulipinolide diepoxide regulation of cell behavior in T24 cells, and a combination of ERK agonists (C16-PAF) was used to explore the involvement of this pathway.
Results: Epitulipinolide diepoxide significantly inhibited the proliferation, invasion, and scratch healing of T24 cells.After Epitulipinolide diepoxide acted on T24 cells, the levels of ERK, JUK, and P38 in the ERK/MAPK pathway were decreased and the level of PERK protein was increased, and the levels of LC3 and ATG5 in autophagy proteins were decreased, resulting in accelerated apoptosis of T24 cells. CHq and C16-PAF partially reversed the Epitulipinolide diepoxide-mediated malignant behavior in T24 cells.
Effect of Ultrasound Treatment on Structural and Physical Properties of Native Maize Starch
Authors: PARRA ESTEBAN JOSUE CARRILLO , Palavecino Pablo , Ribotta Pablo Daniel , Penci Maria Cecilia 
Published: November 2024

Abstract

The focus of this work was to evaluate the differences between the thermal and mechanical energy generated by ultrasound waves on the properties of corn starch, which facilitate the subsequent enzymatic hydrolysis for the generation of porous starches. The results showed that both the thermal and mechanical effects have the capacity to disorganize/alter the structure of starch, impacting on its properties. Characteristics such as particle size, pasting and thermal properties of starch and water absorption were the most affected, while crystallinity was practically unmodified. The thermal effect induced by the ultrasound treatment caused most of the alterations in the properties of corn starch. It was associated with the partial gelatinization of the material due to an increase in the system's temperature. The effect of the mechanical phenomenon of the treatment by ultrasound waves contributed to a lesser extent compared to the thermal effect. The mechanical effect can extend over time, without the aggravating factor of causing starch gelatinization. The combination of both effects could synergistically modify the granular structure of starch. In conclusion, ultrasound waves as a pre-treatment to enzymatic hydrolysis can cause structural disorganization of starch granules and facilitate the subsequent enzymatic attack for the production of porous starches.
Endometriosis and its effects on workplace absenteeism and presenteeism: disrupting inequality regimes
Authors: Howe Danielle , O'Shea Michelle , Duffy Sarah , Eathorne Allie , Armour Mike 
Published: November 2024

Abstract

Endometriosis symptoms, including persistent pelvic pain and fatigue, profoundly affect many people’s ability to undertake paid employment, globally the condition affects between 10-14% of women/those presumed female at birth. Despite its prevalence there is a paucity of research examining supports that might help employees manage their symptoms. The present research investigates how employee endometriosis symptom management shapes workplace presenteeism and absenteeism; while also problematising the organisational practices strengthening inequities for this employee cohort. Individuals engaged in paid employment in Australia (389 respondents) with a self-reported endometriosis diagnosis completed an online survey. Data collected included demographics, symptom experiences, treatment preferences, impacts of endometriosis on work/ career trajectory and disclosure experiences. Results showed that endometriosis symptoms negatively shape absenteeism, presenteeism and career trajectories. Workplace flexibility (hybrid work, breaks, bathroom amenity use) and supportive managers contributed to enhanced productivity (reduced absenteeism and improved presenteeism). Overall, age was the most significant factor influencing absenteeism (P=0.007) and presenteeism (P=0.001), with younger employees reporting greater workplace impacts. Implementing guidelines that prioritise flexibility and inform/educate managers on workplace supports, and challenging the workplace norms (re)producing inequality regimes (discriminating against people with endometriosis based on their gender and ability) emerged as effectual strategies increasing workplace productivity and wellbeing.
Predicting Mean Depth and Area Fraction of Antarctic Supraglacial Melt Lakes with Physics-Based Parameterizations
Authors: Grau Danielle , Hussain Azeez , Robel Alexander 
Published: November 2024

Abstract

Supraglacial melt lakes have been implicated in decreasing albedo and increasing flow speed of the Greenland Ice Sheet and ice shelf disintegration in Antarctica. However, supraglacial melt lakes are largely not represented in current large-scale climate and ice sheet models due to their small size compared to typical model grid spacing. In this study, we first use extensive surface elevation measurements from the ICESat-2 satellite altimetry mission to show that roughness on the Antarctic Ice Sheet surface is largely self-affine, consistent with prior observations of bed roughness beneath ice sheets and geomorphic surfaces more broadly. This self-similarity of ice sheet surfaces across scales enables us to develop a broadly applicable set of simple mathematical expressions parameterizing the average supraglacial melt lake area fraction and lake depth. These parameterizations depend only on two ice sheet roughness parameters and the depth of water supplied as runoff from the surface melt. We derive these parameterizations from statistical fitting of large Monte Carlo ensembles of numerical simulations of water flow on random, self-affine surfaces and show that they provide predictions that are generally consistent with observations. Finally, we predict that on large portions of Antarctic ice shelves supraglacial lakes are likely to, on average, stay less than one meter deep and occupy less than 40% of the ice area, absent changes in ice shelf surface roughness.
Novel Approach for Enhanced Ransomware Detection: Introducing Adaptive Pattern Signature Analysis
Authors: Gromov Frances , Ferreira Julian , Lombardi Patrick , Grigori Samuel 
Published: November 2024

Abstract

The escalating sophistication and frequency of ransomware attacks have rendered traditional detection methods increasingly inadequate, necessitating the development of more adaptive and intelligent security solutions. Adaptive Pattern Signature Analysis (APSA) emerges as a novel framework that dynamically generates and adjusts behavioral signatures in real-time, thereby enhancing detection accuracy and adaptability to evolving ransomware tactics. APSA's architecture integrates advanced pattern recognition techniques with adaptive matching mechanisms, enabling the system to identify and respond to previously unseen ransomware behaviors with minimal latency. Comprehensive evaluations demonstrate APSA's superior performance in detection accuracy, reduced false positive rates, and scalability across diverse operational environments. These findings demonstrate APSA's potential to significantly advance ransomware detection technologies, offering a robust and flexible approach to mitigating the impact of sophisticated cyber threats.
RESERVAS AOS TRATADOS INTERNACIONAIS DE DIREITOS HUMANOS:
Authors: Oliveira Vieira Gustavo , Sesterheim Maria Luiza 
Published: November 2024

A partir da clareira aberta pela Declaração Universal dos Direitos Humanos, passou a se construir um rol de tratados internacionais em matéria de Direitos Humanos, fortalecendo e especializando a sua promoção. Em compensação, novos e mais mecanismos de implementação demandam aprimoramento no sentido de se perquirir a melhoria dos aparatos promotores da sua concretização, como é o caso da problemática que envolve o amplo uso das “reservas” aos tratados. O presente artigo enfrenta, numa abordagem dialética, um dos mecanismos ambíguos no âmbito da universalização dos Direitos Humanos, que são as reservas aos tratados internacionais sobre o assunto. O uso das reservas aos tratados internacionais, que tem limites definidos pelo próprio Direito Internacional, não permitindo ter seu funcionamento em contradição aos objetivos centrais do tratado, padece de um déficit de monitoramento e controle. Tomando o exemplo das reservas à Convenção Internacional sobre o Direito das Crianças, problematiza-se o tema para caracterizar suas contradições e mesmo certos paradoxos, notando que nalguns casos pode funcionar (ou não).
A Novel Web App for Dietary Weight Management: Development, Implementation, and Usability Study
Authors: Oliveira Ashleigh , Wolff John , Alfouzan Nouf , Yu Jin , Yahya Asma , Lammy Kayla , Nakamura Manabu T 
Published: November 2024

Background
Online weight loss programs have ambiguous efficacy. There is a growing body of evidence that weight loss programs when combined with apps have better outcomes; however, many apps lack an evidence-based approach to dietary changes for weight loss and do not rely on a theoretical framework for behavior change.

Objective
This study aimed to describe the development and the preliminary usability and acceptability testing of a web app that uses behavior change techniques (BCTs) to support users of a comprehensive online weight loss program.

Methods
The weight loss program intervention components were nutrient and weight tracking charts that needed a remotely accessible and online format. The app was designed by nutrition researchers and developers in a collaborative effort. A review of BCTs in weight loss and web apps was performed as well as an assessment of user needs to inform the initial prototype. A preliminary app prototype, version 1.0, was provided to participants of a weight loss trial (N=30) to assess for feasibility of its use. A full app prototype, version 2.0, was feasibility and acceptability tested by trial participants (n=11) with formal feedback by Likert-scale survey and open-ended questions. In the final round of testing, a user group of scientists and developers (n=11) was selected to provide a structured 3-month review through which the group met weekly for collective feedback sessions.

Results
The process resulted in a fully developed web app, MealPlot, by the Applied Research Institute, for meal planning and weight tracking that can be used by weight loss users and health professionals to track their patients. MealPlot includes a weight chart, a protein-fiber chart, and a chat feature. In addition, MealPlot has 2 distinct platforms, 1 for weight loss users and 1 for health professionals. Selected BCTs for incorporation into the app were goal setting, feedback, problem-solving, self-monitoring, and social support. Version 1.0 was used successfully to provide a functioning, online weight chart over the course of a 1-year trial. Version 2.0 provided a functional weight chart and meal planning page, but 8 out of 11 participants indicated MealPlot was difficult to use. Version 3.0 was developed based on feedback and strategies provided from user group testing.

Conclusions
The web app, MealPlot, was developed to improve outcomes and functionality of an online weight loss program by providing a remote method of tracking weight, food intake, and connecting users to health professionals for consistent guidance that is not otherwise available in a traditional in-person health care setting. The final version 3.0 of the web app will be refined based on findings of a review study gathering feedback from health professionals and from actual weight loss users who are part of a clinical weight loss trial.
Intensitas Budaya pada Musik Iringan Tari Tiga Serangkai di Sanggar Andari
Authors: Lukyantus Lukyantus , Djau Nurmila Sari , Sagala Mastri Dihita 
Published: November 2024

Tari Tiga Serangkai merupakan karya tari dari Sanggar Andari yang tercipta pada tahun 2002 atas respon terhadap konflik etnis yang terjadi di Kalimantan Barat pada tahun 1996. Kemajemukan itu dilihat oleh Kusmindari Triwati bukan sesuatu yang memecah belah justru menjadi simbolik Persatuan dan menjadi dasar terbentuknya tari Tiga Serangkai. Tari yang tidak lepas dari musik pengiringnya tentunya saling berkorelasi dalam konsep persatuan dari berbagai etnis tersebut, sehingga Intensitas Budaya yang terkandung di dalam karya ini menjadi menarik untuk ditelisik lebih dalam terutama sebagai sebuah medium pemersatu masyarakat yang mejemuk di Kalimantan Barat. Penelitian ini menggunakan jenis penelitian kualitatif dengan menggunakan metode deskriptif serta Etnomusikologi sebagai pendekatan dalam menggali lebih dalam mengenai intensitas budaya dalam sudut pandang musik. Intensitas budaya yang terkandung dalam karya tari Tiga Serangkai oleh Sanggar Andari tampak melalui penyatuan elemen musik dan tarian dari berbagai latar belakang etnis yang ada di Kalimantan Barat. Intensitas Budaya yang terkandung dalam tari Tiga Serangkai bukan hanya sebuah karya gerak tari namun lebih dalam karya tersebut sebagai sebuah penggambaran sejarah, nilai, serta menjadi ruang dialektika antar suku menuju keharmonisan di Kalimantan Barat.

Tiga Serangkai dance is a dance work from Sanggar Andari that was created in 2002 in response to the ethnic conflict that occurred in West Kalimantan in 1996. The plurality is seen by Kusmindari Triwati as not something that divides, but instead becomes a symbolic unity and becomes the basis for the formation of Tiga Serangkai dance. The dance that cannot be separated from the accompanying music is certainly correlated with the concept of unity of the various ethnicities, so that the Cultural Intensity contained in this work becomes interesting to be examined more deeply, especially as a unifying medium for pluralistic communities in West Kalimantan. This research uses qualitative research using descriptive methods and Ethnomusicology as an approach in digging deeper into cultural intensity from a musical point of view. The cultural intensity contained in the Tiga Serangkai dance work by Sanggar Andari is seen through the unification of music and dance elements from various ethnic backgrounds in West Kalimantan. The cultural intensity contained in Tiga Serangkai dance is not only a work of dance movements but deeper than that work as a depiction of history, values, and a dialectical space between tribes towards harmony in West Kalimantan.
Bertahan di Dunia Digital: Koping Religius dengan Penerimaan Diri Korban Perundungan Siber
Authors: Arifi Indirahma , Widiasih Puti Archianti 
Published: November 2024

Perkembangan internet dan penggunaan media sosial yang semakin meningkat menjadi alasan terjadinya perundungan siber, yang merupakan tindakan agresif terus menerus dan seringkali tanpa tujuan yang jelas. Korban perundungan siber cenderung mengalami dampak negatif terhadap penerimaan diri, yang merupakan landasan penting dalam menerima dan memahami kemampuan diri, pengalaman pribadi, dan pengalaman orang lain. Pengalaman negatif korban, dapat dihadapi dengan strategi koping efektif, yakni koping religius sebagai upaya memahami dan menghadapi stresor dengan cara yang dianggap sakral. Oleh karena itu, penelitian ini bertujuan untuk mencari tahu hubungan koping religius dengan penerimaan diri. Penelitian ini menggunakan The Brief Religious Coping (BRCOPE) dan Berger’s Self Acceptance Scale yang keduanya telah diadaptasi. Jumlah subjek sebanyak 206 orang berusia 18-25 tahun. Teknik analisis menggunakan spearman correlation yang menunjukkan hubungan positif antara koping religius positif dengan penerimaan diri (r = 0,160, p = 0,021, p < 0,05) dan hubungan negatif antara koping religius negatif dengan penerimaan diri (r = 0,516, p = 0,000, p < 0,01). Artinya, penelitian ini menemukan bahwa koping religius positif berhubungan dengan peningkatan penerimaan diri pada dewasa awal korban perundungan siber, sementara koping religius negatif berhubungan dengan penurunan penerimaan diri.

The development of the internet and the increasing use of social media are the reasons for cyberbullying, which is a continuous aggressive action and often without a clear purpose. Victims of cyberbullying tend to experience a negative impact on self-acceptance, which is an important foundation in accepting and understanding one's abilities, personal experiences, and the experiences of others. Victims' negative experiences can be faced with effective coping strategies, namely religious coping as an effort to understand and deal with stressors in a way that is considered sacred. Therefore, this study aims to find out the relationship between religious coping and self-acceptance. This study used The Brief Religious Coping (BRCOPE) and Berger's Self Acceptance Scale, both of which have been adapted. The number of subjects was 206 people aged 18-25 years. The analysis technique used Spearman correlation which showed a positive relationship between positive religious coping and self-acceptance (r = 0.160, p = 0.021, p < 0.05) and a negative relationship between negative religious coping and self-acceptance (r = 0.516, p = 0.000, p < 0.01). That is, this study found that positive religious coping is associated with increased self-acceptance in early adult victims of cyberbullying, while negative religious coping is associated with decreased self-acceptance.
Channeling Midsommar from Celtic Rituals to Pagan Culture and Humanist Criticism
Authors: Poetri Maharanny , Melania Cahyani Fitri 
Published: November 2024

Midsommar presents pagan tradition by hosting a midsummer festival by the cult Hårga in Halsingland, Northern Europe. The midsummer festival is a representation of Celtic ritual –consisting of several rituals as a pagan tradition preserved by the Hårga cult. This research aims to identify the representation of Celtic rituals in Ari Aster's Midsommar using Stuart Hall's perspective. Hall (1997) explained that representation is born from the production of the concept of meaning in the mind through language. The representation of Celtic rituals in Midsommar is a form of Hårga’s pagan tradition that among others provokes humanist criticism. This research uses a qualitative method with a cinematography approach. The research data was collected from direct observation of dialogue, narrative, and scenes in the film Midsommar –and presented in the form of selected screenshots. The results of this research include: 1) Midsummer festival is a representation of Celtic ritual. It symbolizes the gratitude of the Hårga cult. 2) Midsummer festival contains ritual instruments that convey the essence of Hårga’s pagan tradition and raise humanist issues. It negates humanity in some of its rituals, thus provoking humanist criticism as a rejection of the Celtic rituals represented.

Midsommar menceritakan tradisi pagan festival musim panas oleh kultus Hårga di desa Halsingland, Eropa Utara. Festival musim panas dalam adalah representasi ritual Kelt -terdiri dari beberapa ritual sebagai tradisi pagan yang dilestarikan kultus Hårga. Penelitian ini bertujuan untuk mengidentifikasikan representasi ritual Kelt dalam film Midsommar karya Ari Aster menggunakan perspektif Stuart Hall. Hall (1997) menjelaskan bahwa representasi lahir dari produksi konsep makna dalam pikiran melalui bahasa. Representasi ritual Kelt dalam Midsommar merupakan bentuk tradisi pagan kultus Hårga yang diantaranya mengundang kritik humanis. Penelitian ini menggunakan metode kualitatif dengan pendekatan sinematografi. Data penelitian dikumpulkan dari pengamatan dialog, narasi, dan adegan secara langsung dalam film Midsommar -dan disajikan dalam bentuk gambar tangkapan layar terpilih. Hasil penelitian ini meliputi: 1) Festival musim panas adalah representasi ritual Kelt. Festival musim panas dalam Midsommar melambangkan rasa syukur dari kultus Hårga. 2) Festival musim panas mengandung instrumen ritual yang menyampaikan tradisi pagan kultus Hårga serta menimbulkan isu humanis. Festival musim panas dalam Midsommar menihilkan kemanusiaan dalam beberapa ritualnya sehingga mengundang kritik humanis sebagai penolakkan terhadap ritual Kelt yang direpresentasikan.
Pengaruh Fear of Missing Out (FOMO) terhadap Binge Watching Gen Z dengan Emotionally Immature Parents
Authors: Pradiansyah Bunga Nadira , Islam Azizah Fajar 
Published: November 2024

Kemudahan akses digital yang dirasakan oleh Gen Z menimbulkan konsekuensi negatif seperti fear of missing out akibat dari rasa cemas tidak bisa mengikuti tayangan yang banyak diperbincangkan di media. Hal tersebut menjadikan perilaku menonton sebagai coping bermasalah. Haluan penelitian ini untuk melihat pengaruh dari fear of missing out (FOMO) terhadap binge wathing Gen Z dengan emotionally immature parents. Penelitian ini menggunakan metode kuantitatif non-probability sampling dengan teknik purposive sampling yang melibatkan 161 responden laki-laki dan perempuan dengan rata-rata usia 14-24 tahun; senang menonton serial/film/drama lebih dari 1 kali tanpa jeda; memiliki pengalaman kurang mengenakkan dengan orang tua kandung. Pengambilan data yang dilakukan secara online melalui kuesioner (angket) mengadaptasi alat ukur Binge Watching Engagement and Symptoms Questionnaire yang dikembangkan oleh Flayelle et al (2018) serta The Online Fear of Missing Out Inventory dikembangkan oleh Sette (2019). Hasil uji regresi ditemukan nilai F bernilai 107.829 dengan nilai B unstandardized 0.635 dengan R square 0.404 dan P value 0,05 > 0,000. Hal ini menunjukkan H0 ditolak, sehingga FOMO berpengruh signifikan terhadap binge watching Gen Z dengan emotionally immature parents dengan persentase sebesar 40.4%. Dengan demikian apabila FOMO meningkat, maka perilaku binge watching Gen Z juga akan meningkat signifikan.

The ease of digital access experienced by Gen Z gives rise to negative consequences such as fear of missing out due to anxiety about not catching up to discussed film in the media. This makes watching behavior a problematic coping. The aim of this study was to see the effect of FOMO on binge watching Gen Z with emotionally immature parents. This study used a quantitative non-probability sampling with a purposive sampling technique involving 161 male and female respondents with an average age of 14-24 years; enjoy watching series/films/dramas more than once without a break; have unpleasant experiences with biological parents. Data collection carried out online through a questionnaire adapting the Binge Watching Engagement and Symptoms Questionnaire measuring tool developed by Flayelle et al (2018) and The Online Fear of Missing Out Inventory developed by Sette (2019). The results found an F value of 107.829 with an unstandardized B value of 0.635; R square of 0.404; P value of 0.05> 0.000. This shows that H0 is rejected, so FOMO has a significant effect on binge watching Gen Z with emotionally immature parents with a percentage of 40.4%. Thus, if the FOMO increases, Gen Z's binge watching will also increase significantly.