bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Levels of Nutrient Management on Economics of Soybean-onion and Soybean-potato Cropping System
Authors: Patil S.S. , Hiwale S.D. , Patil P.P. , Yadav K.R. , Patil S.R. , Bisarya Dipti 
Published: November 2024

Background: Nutrient management and cropping sequence are two important factors which affect productivity and profitability of crop. Profitability is one the important part of the successful crop production. Soybean fixes atmospheric nitrogen in soil and partially fulfills the nitrogen requirement of succeeding crops. There is a need for a suitable substitute crop or cropping systems after soybean to improve the soil fertility and productivity to maximize the profitability. The plains of Maharashtra are well suited for onion and potato cultivation. There is scope for increasing the area, production and productivity of onion and potato crop. Majority of farmers in Maharashtra following soybean-wheat and soybean-chickpea crop sequence while in present investigation soybean is grown in sequence with vegetable crop such as onion and potato which could help to increase profitability through higher net return and B: C ratio. Methods: The experiment was laid out in split plot design with three replications. Six combinations of two crop sequences (soybean-onion and soybean-potato) and three levels of nutrient management viz., 50% RDF+FYM 5 t ha-1+ biofertilizer (N1), 75 % RDF+ FYM 5 t ha-1+ biofertilizer (N2) and 100 % RDF+ FYM 5 t ha-1+ biofertilizer (N3) were the main plot treatments in kharif season replicated three times in randomized block design. During rabi season each main plot treatment of nutrient management level was split into three sub plot treatments with three levels of recommended dose of fertilizer viz., 75% RDF (F1), 100% RDF (F2) and 125% RDF (F3) to rabi season crops resulting in eighteen treatment combinations replicated three times in split plot design. The data pertaining to growth characteristics, yield characteristics, economics of soybean (kharif) and onion or potato (rabi) was collected at regular interval in 2017-18, 2018-19 and 2019-20 at Agronomy Farm, Dr. PDKV, Akola which was analyzed statistically in SPD (split plot design). Result: Soybean-onion crop sequence registered higher profitability in terms of GMR, NMR and B: C in comparison with soybean - potato crop sequence. Soybean crop supplied with 100% RDN+ 5 t FYM ha-1 + Biofertilizer (Rhizobium japonicum+ PSB+ Tricoderma viridi) recorded highest GMR, NMR and B:C ratio over lower levels of treatments in all year experimentation. Rabi crops treated with 125% RDF recorded GMR, NMR and B:C ratio over lower levels of treatments in all years of experimentation.
ЕФЕКТИВНІСТЬ АЛГОРИТМІВ МАШИННОГО НАВЧАННЯ ДЛЯ КЛАСИФІКАЦІЇ ЗМІН СТРУКТУРИ ЛЕГЕНЬ У ПОСТКОВІДНИХ ТА ГОСТРИХ СТАДІЯХ COVID-19
Authors: Лутченко Вікторія , Бабенко Віталій , Настенко Євген , Линник Микола 
Published: November 2024

Комп'ютерна томографія (КТ) є важливим інструментом для діагностики змін структури легень завдяки своїй високій точності та чутливості у визначенні патологічних змін на тканинах. Деталізація тканин легень є основною причиною ефективності даного методу у виявленні як гострих стадій захворювання COVID-19, так і ускладнень, що виникли на тлі постковідного періоду (починається через три місяці після гострої стадії). Однак, важливу роль відіграють медичні фахівці, які працюють зі знімками КТ. Застосування комп’ютерних алгоритмів машинного навчання може сприяти покращенню медичної практики, від чого виграють як фахівці, отримуючи підтримку у прийнятті діагностичних рішень, так і пацієнти, отримуючи своєчасне та ефективне лікування. В даному дослідженні використовувалась база зрізів КТ легень, що була надана фахівцями ДУ «Національний інститут фтизіатрії та пульмонології імені Ф.Г. Яновського НАМН України» у рамках співпраці з КПІ ім. Ігоря Сікорського. Усього база містила 10 031 зріз КТ легень, які були взяті у 36 знеособлених пацієнтів. З них, 5 213 (52%) зрізів містили ознаки гострої фази COVID-19, а 4 818 (48%) – ознаки постковіду. Перед процесом моделювання було прийнято рішення розподілити пацієнтів в тренувальну (80.6%) і тестову (19.4%) вибірки. Завдяки такому розподіленню співвідношення між зрізами КТ у двох вибірках складало 3:1. Для вилучення інформативних ознак з наданих зрізів застосовувались методи текстурного аналізу, такі як: GLCM, GLRLM, GLDS та LBP. Використовуючи отримані ознаки, була проведена класифікація стану легень наступними алгоритмами машинного навчання: Random Forest, Support Vector Machine (SVM), K-Nearest Neighbors (KNN), XGBoost, LightGBM, а також випадковий ліс дерев оптимальної складності (ВЛДОС). За допомогою мір точності, чутливості та специфічності було визначено, що виявляти зміни структури легень, як у постковідних пацієнтів, так і у пацієнтів з гострою стадією COVID-19, здатні моделі XGBoost LightGBM та ВЛДОС з показниками точності на тестовій вибірці 85%, 86% та 89% відповідно. Подібні результати дозволяють надавати необхідну для медичних фахівців підтримку у прийнятті діагностичних рішень, що сприяє кращому виявленню змін структури легень. В майбутніх дослідженнях планується розробка програмного забезпечення з можливостями пояснювального інтелекту, а також подальша інтеграція застосунку в чинну медичну інфраструктуру.
The Relationship Between Safety Climate and Safety Performance in Large-Scale Building Construction Industries in Ethiopia
Authors: Abegaz Teferi , Deressa Wakgari , Moen Bente Elisabeth 
Published: November 2024

This study examines the relationship between safety climate and safety performance in large-scale construction sites in Ethiopia. A cross-sectional survey was conducted among 1,203workers from 22 large-scale construction sites. The Nordic Safety Climate Questionnaire was administered using interviews. A model was hypothesized to determine the interrelations between safety climate and performance; examined and validated using confirmatory factor analysis. The results show that the mean score of the seven safety climate dimensions was low: 2.70, ranging from 2.33 to 3.08. Similarly, the mean score of the safety performance construct was 2.95 for safety participation and 3.58 for safety compliance. The model predicts a strong positive correlation between safety climate and the safety performance constructs with 29.2% of the variance in safety involvement and 28.6% of the variance in safety compliance. The suggested association between self-reported injuries and safety climate was not confirmed. Nonetheless, a Pearson correlation analysis demonstrates a statistically significant negative correlation with safety climate. In conclusion, a low score for all the safety climate dimensions shows safety in the construction sector needs improvement. Safety climate positively influences employees’ safety behavior (safety compliance and safety participation) and minimizes occupational injuries.
PENERAPAN SISTEM PENDUKUNG KEPUTUSAN DALAM MENENTUKAN PRIORITAS LOKASI PEMASARAN PADA PT. ASKRINDO CABANG MEDAN MENGGUNAKAN METODE AHP DAN PROMETHEE
Authors: Zulfani Fathania , Suryamen Haris , Wahyuni Ullya Mega 
Published: November 2024

PT. (Persero) Asuransi Kredit Indonesia merupakan salah satu Badan Usaha Milik Negara (BUMN) yang bergerak dalam asuransi atau penjaminan. Keberadaan PT Askrindo yang merupakan salah satu Badan Usaha Milik Negara (BUMN) senantiasa mengiringi keberhasilan pembangunan ekonomi Bangsa dan Negara Republik Indonesia. Pemasaran sangat berpengaruh besar bagi perusahaan termasuk PT Askrindo, namun dalam menentukan prioritas lokasi pemasaran yang strategis dibutuhkan banyak perhitungan terhadap faktor-faktor penentu agar terhindar dari kerugian materi maupun non-materi. Tujuan dari penelitian ini adalah membangun Sistem Pendukung Keputusan (SPK) dengan kombinasi metode Analytical Hierarchy Process (AHP) dan metode PROMETHEE yang dapat menjadi pertimbangan dalam pemilihan prioritas lokasi pemasaran berdasarkan kriteria yang telah ditetapkan. Penggunaan metode AHP dan PROMETHEE dalam memperhitungkan prioritas lokasi pemasaran dengan beberapa alternatif lokasi, dapat membantu kegiatan pengambilan keputusan sehingga meningkatkan efektivitas perusahaan untuk menghasilkan suatu keputusan yang tepat. Dengan adanya sistem pendukung keputusan, dapat menjadi solusi untuk membantu PT Askrindo Cabang Medan dalam pengambilan keputusan pemilihan prioritas lokasi pemasaran terbaik.
Challenges in identifying papilledema amid myopic peripapillary atrophy and optic disc atrophy in a patient with idiopathic intracranial hypertension and high myopia: a case report
Authors: Han I Joon , Choi Ji Youn , Park Kyung-Ah 
Published: November 2024

Abstract

Background
Idiopathic intracranial hypertension (IIH) is a disease entity characterized by elevated intracranial pressure, which usually accompanied by papilledema. However, diagnosing papilledema can be challenging in patients with preexisting ocular conditions, such as high myopia.
Case presentation
A 39-year-old woman with a long-standing history of high myopia presented with visual field constriction. Her visual acuity was decreased in both eyes, and she also reported morning headaches, pulsatile tinnitus, and intermittent periocular pain. Although she was diagnosed with IIH based on a cerebrospinal fluid study, there was no evident papilledema, which may have been masked by myopic changes in optic nerve and peripapillary retinal nerve fiber layer. After treatment for IIH with acetazolamide, her visual field and visual acuity markedly improved, and her symptoms were relieved.
Conclusions
In highly myopic patients, myopic changes in optic nerve head may obscure papilledema, complicating the diagnosis of IIH. This unusual case highlights the need for detailed history taking and a comprehensive clinical evaluation in patients with high myopia. Clinicians should suspect IIH in the presence of symptoms such as pulsatile tinnitus, morning headache, and visual field constriction, even in the absence of evident papilledema.
Exploring the Molecular Interactions Between Nephrolithiasis and Carotid Atherosclerosis: Asporin as a Potential Biomarker
Authors: Hua Yibo , Zhou Zijian , Miao Suyu , Wang Zijie , Wang Shangqian , Xi Lei , Song Rijin , Meng Xianghu 
Published: November 2024

Abstract

Background
Increasing evidence has suggested nephrolithiasis has a close linkage with carotid atherosclerosis (CAS). Randall’s plaque (RP) is considered the precursor lesion of nephrolithiasis. This study aimed to examine the crosstalk genes and potential molecular mechanisms between RP and CAS.
Methods
We downloaded microarray data for calcium oxalate (CaOx) RP and CAS from the Gene Expression Omnibus (GEO) repository. To pinpoint common genes associated with RP and CAS, researchers employed weighted gene co-expression network analysis (WGCNA) alongside differentially expressed gene (DEG) analysis. Enrichment analyses using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and Gene Ontology (GO) were conducted on the common genes. A central gene was discovered, and a receiver operating characteristic (ROC) curve was created to assess its diagnostic effectiveness. The hub gene was also analyzed using Gene Set Enrichment Analysis (GSEA). Additionally, the xCell algorithm evaluated immune cell infiltration levels, and the relationship between each immune cell type and the central gene was analyzed. Subsequently, the hub gene's expression in human RP and CAS tissues was assessed using quantitative reverse-transcription PCR (qRT-PCR) and immunohistochemistry (IHC) staining. Finally, we established a CaOx nephrolithiasis rat model by administering 1% ethylene glycol. The expression patterns of ASPN in rat kidney tissues were confirmed using IHC and qRT-PCR.
Results
WGCNA was used to select highly correlated modules and resulted in 225 intersection genes in GSE73680 and GSE100927. On the other hand, 23 overlapping DEGs were identified in GSE117518 and GSE43292. Asporin (ASPN) emerged as the central gene linking RP and CAS by intersecting the highly correlated module genes from WGCNA with the differentially expressed genes (DEGs). The findings on immune infiltration indicated a notable correlation between ASPN and various immune cells in both RP and CAS. IHC and qRT-PCR verified that ASPN expression was lower in human RP and CAS plaque tissues than in normal tissues. Furthermore, the expression pattern of ASPN in CaOx nephrolithiasis model rats was consistent with the results in human tissues.
Conclusion
We identified ASPN as an important crosstalk gene in RP and CAS. Further study of the immune response and osteoblast differentiation may reveal the shared pathogenesis between RP and CAS.
Terrain correction algorithms for urban microgravity surveys: Applications in revealing buried faults in urban noise working conditions
Authors: Zhang Wei , Hao Ming , Chen Yongling , Li Hua , Yang Jian , Wang Qiao , Wang Xiangpeng , Yuan Jianlong 
Published: November 2024

Abstract

The dense clusters of buildings in cities considerably affect the accuracy of urban microgravity measurements. This study introduced a set of new high-precision algorithms for calculating vicinity, median- and far-zone terrain correction to solve precision problems of gravity surveys on the magnitude of the microgravity scale in cities. The vicinity and median-zone algorithms first divided complex artificial buildings and natural terrain into a set of multiple triangles and then calculated corresponding analytical solutions for each triangle. Finally, we obtained high-accuracy terrain correction values by accumulating; errors only occurred from the fitting degree between triangulation and real terrain features, but the subdivision of the triangular mesh was finer, and the calculation precision was higher. Far-zone algorithms use open global high-resolution digital elevation model (DEM) data to calculate gravity terrain corrections, and the DEM grid nodes used here were up to 30 m. To increase the effective detection accuracy of urban microgravity explorations using these new methods and to further compare their practical application in urban geological surveys, the exploration effects of microgravity, micro-tremor, transient electromagnetic, and reflection seismic methods were compared and analyzed using the buried Sumatou fault in the main urban area of Tianfu new district in Chengdu as an example, The results revealed that the microgravity method has good adaptability to field conditions and is not affected by urban noise such as power line electromagnetic and traffic vibration fields. Therefore, areal microgravity measurements can be used to investigate buried urban faults.
Novel mRNA biomarker-based liquid biopsy for the detection of resectable pancreatic cancer
Authors: Lee Jong-chan , Kang Sung Won , Sim Eun-Jin , Bae Jin-Sik , Koo Seong-mo , Byoun Mun-sub , Kwon Serin , Hong Seoi , Kim Yunji , Youn Yuna , Jung Kwangrok , Kim Jaihwan , Jeong Hyoung Hwa , Kim Jihie , Hwang Jin-Hyeok 
Published: November 2024

Abstract

Background
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies and most often diagnosed at an advanced stage. Identification of markers for the early diagnosis of PDAC is crucial. In this study, we aimed to identify novel mRNA biomarkers for diagnosing PDAC, focusing on early-stage tumorigenesis and associated immunological changes.
Methods
Blood samples and clinical information from 1,963 individuals were obtained from a single tertiary hospital between 2015 and 2021. Candidate mRNA biomarkers were identified through literature review, and their expression levels in buffy coat samples were measured using reverse-transcription quantitative polymerase chain reaction. Machine learning-based feature selection confirmed the final biomarker panel, which was tested using an independent dataset for diagnostic performance.
Results
In total, 1,504 individuals (417 patients with PDAC and 1,087 non-diseased controls) were eligible for the study. Among the 55 candidate biomarkers identified, 15 mRNAs (CCL5, CCR5, CLEC7A, CXCL8, CXCR2, CXCR4, FOXP3, IFNA1, IFNL1, PTGES, PTGES2, PTGS2, SLC27A2, TNF, and VEGFA) were selected based on their diagnostic performance in distinguishing PDAC from control groups. The final model, HELP-15 (Human Early Liquid biopsy for PDAC), identified all PDAC stages (area under the curve [AUC] = 0.956) in the test set. For resectable pancreatic cancer (RPC), the AUC was 0.968, compared to 0.910 for carbohydrate antigen 19 − 9 (CA19-9). The combination of the panel and CA19-9 levels had an AUC of 0.985 in patients with RPC. For all PDAC stages in patients with normal CA19-9 levels, the AUC of the panel was 0.967, whereas CA19-9 alone or in combination with the panel had AUCs of 0.658 and 0.885, respectively.
Conclusion
Compared to CA19-9, the mRNA biomarker panel, HELP-15, significantly improved diagnostic performance in patients with RPC, particularly in those with normal CA19-9 levels.
Bridging the Digital Divide: Affordability and Adoptability of Health Tech in Pakistan’s Evolving Healthcare Landscape
Authors: Fayez Muhammad , Begum Ruqayya , Khan Laiba , Ahmad Manzoor , Ahmed Wasiq , Sana Fatima 
Published: November 2024

Abstract

Background:
Digital health technology (DHT) offers great promise for revolutionizing healthcare delivery in limited-resource settings such as Pakistan due to existing challenges, including low infrastructure, scarcity of resources, and digital partitioning. The purpose of this study was to explore the affordability and adoption status of health technology among diabetic patients in Pakistan.
Methods:
A descriptive approach was employed, and primary data were collected via questionnaires from 600 diabetes patients from different areas of Pakistan. The use of a random sampling technique enabled collection from different geographical areas, leading to the recruitment of a broad range among the diabetic population. The descriptive analysis was performed via SPSS 23, and Excel 16 was used to categorize the data into different patterns/trends concerning DHT awareness, usage, and affordability.
Results:
The results reveal that 65% of the population is aware of DHT, and this high awareness has translated into practical usage at a rate of approximately 58%, illustrating additional barriers to adoption beyond simple knowledge, namely, costs and perceived utility. Additionally, 60% indicated that they could not afford DHT, and only 36.1% reported that they had health insurance. The study also noted variability in DHT use, with blood glucose meters and insulin pens being the most common devices used. There is a significant willingness to adopt DHT (97%), although this comes with a range of challenges.
Conclusion:
This study underscores the need to address the digital divide in Pakistan by improving affordability, access, and support for DHT. Bridging these gaps could enhance healthcare access and quality, particularly for managing chronic conditions such as diabetes. Effective public policies and initiatives are crucial to promoting DHT adoption and ensuring equitable healthcare delivery across the country.
AD-214 anti CXCR4 i-body-Fc fusion for the treatment of idiopathic pulmonary fibrosis
Authors: Lynch Jason Paul , Organ Louise , Tomusange Khamis , Kowalczyk Lukasz , Hartman Dallas , Tester Angus , Hosking Chris , Foley Michael 
Published: November 2024

Abstract

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive lung disease characterized by scarring and tissue remodelling. Current treatments have limited efficacy and significant side effects. To address these limitations, we developed AD-214, an anti-CXCR4-Fc-fusion protein comprised of an anti-CXCR4 i-body (AD-114) tethered at its C terminus to constant domains 2 and 3 of the Fc region of a mutated human IgG1 lacking effector function. AD-214 binds with high affinity and specificity to CXCR4, modulates intracellular signaling and inhibits key fibrotic pathways. Using fibrosis models, we demonstrate that AD-214 treatment significantly reduces collagen deposition and lung remodelling and has a unique mode of action. In Phase 1 clinical trials intravenous (IV) infusion of AD-214 led to high and sustained CXCR4 receptor occupancy (RO); however, whether RO and efficacy are causally linked remained to be determined. Herein, we demonstrate that CXCR4 RO by AD-214 inhibits primary human leukocyte migration, a model fibrotic process, and that migration inhibition is achievable at concentrations of AD-214 present in the serum of healthy human volunteers administered AD-214. Taken together, these data provide proof of concept for AD-214 as a novel treatment strategy for IPF, and suggest that clinically feasible dosing regimens may be efficacious.
A quasi-experimental study based on evidence-based evidence to enhance the mental health literacy of primary and secondary school teachers
Authors: Lin Danlin , Liao Yuanyuan , Ameyaw Moses Agyemang , Xiao YunYi , Shan Ke 
Published: November 2024

Abstract

In recent years, the mental health problems of Chinese primary and secondary school students have become increasingly alarming. As the gatekeepers of students, primary and secondary school teachers play a crucial role in students' mental health. Their knowledge and understanding of mental health, known as mental health literacy, is beneficial for their personal development and has a significant impact on students' mental health and well-being. This study aims to explore the distinctive features of the mental health literacy of primary and secondary school teachers by formulating the internal structure of mental health literacy. Additionally, a quasi-experimental study of "whole-teacher mental health education" based on the unique dimensions of mental health literacy is employed to enhance the mental health literacy of the teachers in the experimental subjects.The results showed that a sense of Mental Health Education Mission (EHEM) is a special feature that distinguishes elementary and secondary school teachers from the general public in terms of mental health literacy. Based on this evidence-based findings, a quasi-experimental study was conducted on "Expert guidance and assistance, as well as Teacher experience and practice." An experiential workshop was conducted using EHEM as the starting point, significantly improving mental health literacy among the teachers in the experimental group. This reference value is crucial for enhancing the mental health literacy of primary and secondary school teachers. It also serves as a tool for teachers to assist and encourage the mental health growth of students, and to foster the sustainable development of comprehensive mental health education in primary and secondary schools.