bluuebunny/crossref_metadata_2025_split huggingface dataset:
An optimization approach for congestion control in network routing with quality of service requirements
Authors: Avella Pasquale , Bernardi Giacomo , Boccia Maurizio , Mattia Sara 
Published: March 2019

AbstractIn this paper we study a network design problem arising in the management of a carrier network. The aim is to route a traffic matrix, minimizing a measure of the network congestion while guaranteeing a prescribed quality of service. We formulate the problem, devise presolve procedures to reduce the size of the corresponding mixed‐integer programming formulation and show that the proposed approach can efficiently solve some real‐life problems, leading to an improvement with respect to the current practice in a real case study.
Interpreting Aromaticity and Antiaromaticity through Bifurcation Analysis of the Induced Magnetic Field
Authors: Pino‐Rios Ricardo , Cárdenas‐Jirón Gloria , Ruiz Lina , Tiznado William 
Published: March 2019

AbstractIn all molecules, a current density is induced when the molecule is subjected to an external magnetic field. In turn, this current density creates a particular magnetic field. In this work, the bifurcation value of the induced magnetic field is analyzed in a representative set of aromatic, non‐aromatic and antiaromatic monocycles, as well as a set of polycyclic hydrocarbons. The results show that the bifurcation value of the ring‐shaped domain adequately classifies the studied molecules according to their aromatic character. For aromatic and nonaromatic molecules, it is possible to analyze two ring‐shaped domains, one diatropic (inside the molecular ring) and one paratropic (outside the molecular ring). Meanwhile, for antiaromatic rings, only a diatropic ring‐shaped domain (outside the molecular ring) is possible to analyze, since the paratropic domain (inside the molecular ring) is irreducible with the maximum value (attractor) at the center of the molecular ring. In some of the studied cases, i. e., in heteroatomic species, bifurcation values do not follow aromaticity trends and present some inconsistencies in comparison to ring currents strengths, showing that this approximation provides only a qualitative estimation about (anti)aromaticity.
Utilization of transdermal fentanyl in German nursing home residents from 2010 to 2014
Authors: Jobski Kathrin , Bantel Carsten , Hoffmann Falk 
Published: March 2019

AbstractPurposeTransdermal fentanyl (TF) is the most commonly used opioid in Germany although it is associated with an increased risk for hypoventilation and potentially life‐threatening respiratory depression if used inappropriately. The objective of this study was to characterize nursing home residents newly receiving TF with regards to (1) patients' conditions at patch initiation, (2) previous analgesic treatment, and (3) the initial TF dose.MethodsUsing claims data (2010‐2014), we studied a cohort of new nursing home residents aged greater than or equal to 65 years initiating TF.ResultsTF was the most commonly prescribed opioid in nursing home residents. During their nursing home stay, 8571 persons (median age: 86 years, 79.2% female and 28.6% with a diagnosis of cancer) started TF (6.7% of all residents). Almost half of the new TF users were opioid‐naïve and 56.2% of those who had been treated with opioids in the 180 days before TF initiation had only received low potency opioids such as tilidine/naloxone or tramadol. Opioid‐naïve TF users more often were care dependent and had a higher prevalence of dementia than patients previously treated with opioids. Overall, patients often received anxiolytic/hypnotic (29.7%) or antipsychotic (31.4%) comedication. About 61% of opioid‐naïve users started with the lowest available dose (12.5 μg/h), followed by 32% treated with 25 μg/h.ConclusionsTF as a noninvasive treatment option is the first‐choice opioid in German nursing homes. Although initial doses seemed more appropriate than those identified in previous studies, the large proportion of opioid‐naïve patients in this vulnerable population warrants attention, given the limited controllability of the treatment.
The Industrial Camera Modules Market
Authors: González Ana Belén , Pozo Jose 
Published: March 2019

AbstractCamera modules have now taken a major share of the camera industry due to becoming a key part of an important consumer electronic device, the smartphones. In this article, an analysis of the camera module industry is offered including market forecast, company ecosystem, and consumer trends. The focus is on camera modules serving consumer electronics such as mobile phones, but we also give an overview of other applications, in particular the automotive ones.
Janus Nanoparticle Emulsions as Chiral Nanoreactors for Enantiomerically Selective Ligand Exchange
Authors: Lu Jia En , Peng Yi , Chen Shaowei 
Published: March 2019

AbstractJanus nanoparticles capped with a hydrophobic and hydrophilic hemisphere of mercapto ligands can self‐assemble into hollow, emulsion‐like nanostructures in controlled media. As the nanoparticle emulsions are chiroptically active exhibiting a plasmonic circular dichroism absorption in the visible range, they can be exploited as a unique chiral nanoreactor by selective encapsulation of d‐enantiomer into the water phase of the water‐in‐oil emulsions for directional functionalization of the nanoparticles and endow the resulting nanoparticles with select chirality. This is demonstrated in the present study with gold Janus nanoparticles functionalized with (hydrophobic) hexanethiolates and (hydrophilic) 3‐mercapto‐1,2‐propandiol, and d,l‐cysteine is used as the molecular probe. Experimental results demonstrate that d‐cysteine is the preferred enantiomers entrapped within the nanoparticle emulsions, where the ensuing ligand exchange reaction is initially confined to the hydrophilic face of the Janus nanoparticles. This suggests that with a deliberate control of the reaction time, chiral Janus nanoparticles can be readily prepared by ligand exchange reactions even with a racemic mixture of ligands.
An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere
Authors: Pakhomova Svetlana , Boeglin William E. , Neau David B. , Bartlett Sue G. , Brash Alan R. , Newcomer Marcia E. 
Published: March 2019

AbstractThe regio‐ and stereo‐specific oxygenation of polyunsaturated fatty acids is catalyzed by lipoxygenases (LOX); both Fe and Mn forms of the enzyme have been described. Structural elements of the Fe and Mn coordination spheres and the helical catalytic domain in which the metal center resides are highly conserved. However, animal, plant, and microbial LOX each have distinct features. We report five crystal structures of a LOX from the fungal plant pathogen Fusarium graminearum. This LOX displays a novel amino terminal extension that provides a wrapping domain for dimerization. Moreover, this extension appears to interfere with the iron coordination sphere, as the typical LOX configuration is not observed at the catalytic metal when the enzyme is dimeric. Instead novel tetra‐, penta‐, and hexa‐coordinate Fe2+ ligations are apparent. In contrast, a monomeric structure indicates that with repositioning of the amino terminal segment, the enzyme can assume a productive conformation with the canonical Fe2+ coordination sphere.
Language ideologies in science education
Authors: Lemmi Catherine , Brown Bryan A. , Wild Andrew , Zummo Lynne , Sedlacek Quentin 
Published: March 2019

AbstractDrawing on sociolinguistics research regarding common beliefs and justifications about language, we applied notions of language ideology to an analysis of the formative assessment practices of secondary science teachers from linguistically diverse schools. We identified two language ideologies that were demonstrated by teachers as they engaged in the formative assessment of student work. Here, we introduce the termslanguage‐exclusive ideologyandlanguage‐inclusive ideology. Alanguage‐exclusive ideologyholds that certain forms of language are expected in a science class, and others are not appropriate. What we have termed alanguage‐inclusive ideologysuggests that multiple forms of language use are acceptable in science classrooms, and this approach finds synergies with the literature on translanguaging, or the integration of multiple languages for complex communicative purposes. We argue that science teacher educators should consider teachers’ language ideologies as they prepare professional development and preservice teacher education curriculum materials, and we discuss potential implications for science education and teacher education. Finally, we call for more explicit consideration of issues of language ideology within the science education community to understand how various approaches to language can provide affordances or barriers to content learning and language development.
Production of medium chain length polyhydroxyalkanoate from acetate by engineered Pseudomonas putida KT2440
Authors: Yang Songyuan , Li Suhang , Jia Xiaoqiang 
Published: March 2019

Abstract
Pseudomonas putida was metabolically engineered to produce medium chain length polyhydroxyalkanoate (mcl-PHA) from acetate, a promising carbon source to achieve cost-effective microbial processes. As acetate is known to be harmful to cell growth, P. putida KT2440 was screened from three Pseudomonas strains (P. putida KT2440, P. putida NBRC14164, and P. aeruginosa PH1) as the host with the highest tolerance to 10 g/L of acetate in the medium. Subsequently, P. putida KT2440 was engineered by amplifying the acetate assimilation pathway, including overexpression of the acs (encoding acetyl-CoA synthetase) route and construction of the ackA-pta (encoding acetate kinase-phosphotransacetylase) pathway. The acs overexpressing P. putida KT2440 showed a remarkable increase of mcl-PHA titer (+ 92%), mcl-PHA yield (+ 50%), and cellular mcl-PHA content (+ 43%) compared with the wild-type P. putida KT2440, which indicated that acetate could be a potential substrate for biochemical production of mcl-PHA by engineered P. putida.
When working memory is in a mood: Combined effects of induced affect and processing of emotional words
Authors: Rączy Katarzyna , Orzechowski Jarosław 
Published: March 2019

AbstractIt is already well established that the working memory system can be influenced by moods or emotional stimuli. However, the exact combined impact of these two on the performance of working memory remains a puzzle. To examine the effect that the emotional content of stimuli has on working memory performance, 90 participants performed a 2-back task with emotional content (positive, neutral, and negative words) when they were in a positive, neutral, or negative mood. Repeated-measures ANOVA with mood as between-subjects factor and emotional load as within-subjects factor revealed a main effect of emotional content for both performance accuracy and reaction times in a 2-back task, and a main effect of mood for performance accuracy. Participants reacted significantly faster to negative words independently of their mood state. They were significantly more accurate when they were in the positive mood, but when they processed positive words they were less accurate. Additionally, to test whether loading the working memory system can reset the combined effect of mood and emotional stimuli, we measured the participants’ mood before and after they performed the n-back task; this revealed a significant effect of the n-back task on the mood. Together, these results suggest that although mood and emotional content do have a robust effect on working memory, in some instances combining them does not heighten their individual effects. Moreover, the results also show that participants might be easily distracted from moods by simply performing an n-back task.
Nudges that should fail?
Authors: TOR AVISHALOM 
Published: March 2019

AbstractProfessor Sunstein (2017) discusses the possible causes for and policy implications of the failure of nudges, with special attention to defaults. Though he focuses on nudges that fail when they should succeed, Sunstein recognizes that some failures reveal that a nudge should not have been attempted to begin with. ‘Nudges that fail’, however, does not consider fully the relationship between the outcomes of nudging and their likely welfare effects, most notably neglecting the troubling case of nudges that succeed when they should fail. Hence, after clarifying the boundaries of legitimate nudging within a libertarian-paternalistic approach and noting the fourfold relationship between the efficacy of nudging and its normative desirability, this article evaluates more fully the case of failed nudges and examines the hitherto unaddressed problem of successful yet undesirable nudges. This analysis shows that the failure of nudging bears only limited diagnostic value, while the success of a nudge is even less indicative of its normative status. The article concludes with recommendations for policy-makers who wish to employ nudges that are not only efficacious, but also likely to advance the subjective well-being of the individuals they target.
A Simultaneous Cluster Analysis of Cognitive, Emotional, and Personality Factors and Insomnia and Sleep Quality Among Earthquake Victims
Authors: Khazaie Habibolah , Zakiei Ali , Komasi Saeid 
Published: March 2019

ABSTRACTObjectiveThe current study compares the measures of sleep quality and intensity of insomnia based on the clustering analysis of variables including dysfunctional beliefs and attitudes about sleep, experiential avoidance, personality traits of neuroticism, and complications with emotion regulation among the individuals struck by an earthquake in Kermanshah Province.MethodsThis study is a cross-sectional study that was carried out among earthquake victims of Kermanshah Province (western Iran) in 2017. Data were gathered starting 10 days after the earthquake and lasted for 2 weeks; of 1,200 standard questionnaires distributed, 1,001 responses were received, and the analysis was performed using 999 participants. The data analysis was carried out using a cluster analysis (K-mean method).ResultsTwo clusters were identified, and there is a significant difference between these two clusters in regard to all of the variables. The cluster with higher mean values for the selected variables shows a higher intensity of insomnia and a lower sleep quality.ConclusionsConsidering the current results, it can be concluded that variables of dysfunctional attitudes and beliefs about sleep, experiential avoidance, the personality traits of neuroticism, and complications with emotion regulation are able to identify the clusters where there is a significant difference in regard to sleep quality and the intensity of insomnia. (Disaster Med Public Health Preparedness. 2019;13:745–752)
COMPUTABILITY IN UNCOUNTABLE BINARY TREES
Authors: JOHNSTON REESE 
Published: March 2019

AbstractComputability, while usually performed within the context of ω, may be extended to larger ordinals by means of α-recursion. In this article, we concentrate on the particular case of ω1-recursion, and study the differences in the behavior of ${\rm{\Pi }}_1^0$-classes between this case and the standard one.Of particular interest are the ${\rm{\Pi }}_1^0$-classes corresponding to computable trees of countable width. Classically, it is well-known that the analog to König’s Lemma—“every tree of countable width and uncountable height has an uncountable branch”—fails; we demonstrate that not only does it fail effectively, but also that the failure is as drastic as possible. This is proven by showing that the ω1-Turing degrees of even isolated paths in computable trees of countable width are cofinal in the ${\rm{\Delta }}_1^1\,{\omega _1}$-Turing degrees.Finally, we consider questions of nonisolated paths, and demonstrate that the degrees realizable as isolated paths and the degrees realizable as nonisolated ones are very distinct; in particular, we show that there exists a computable tree of countable width so that every branch can only be ω1-Turing equivalent to branches of trees with ${\aleph _2}$-many branches.
Standing waves of modified Schrödinger equations coupled with the Chern–Simons gauge theory
Authors: d'Avenia Pietro , Pomponio Alessio , Watanabe Tatsuya 
Published: March 2019

AbstractWe are interested in standing waves of a modified Schrödinger equation coupled with the Chern–Simons gauge theory. By applying a constraint minimization of Nehari-Pohozaev type, we prove the existence of radial ground state solutions. We also investigate the nonexistence for nontrivial solutions.
Glucose-restriction increasesTrichomonas vaginaliscellular damage towards HeLa cells and proteolytic activity of cysteine proteinases (CPs), such as TvCP2
Authors: Miranda-Ozuna Jesús F. T. , Rivera-Rivas Luis Alberto , Cárdenas-Guerra Rosa Elena , Hernández-García Mar Sarai , Rodríguez-Cruz Sarahí , González-Robles Arturo , Chavez-Munguía Bibiana , Arroyo Rossana 
Published: March 2019

AbstractTrichomonas vaginalisinduces cellular damage to the host cells (cytotoxicity) through the proteolytic activity of multiple proteinases of the cysteine type (CPs). Some CPs are modulated by environmental factors such as iron, zinc, polyamines, etc. Thus, the goal of this study was to assess the effect of glucose onT. vaginaliscytotoxicity, proteolytic activity and the particular role of TvCP2 (TVAG_057000) during cellular damage. Cytotoxicity assays showed that glucose-restriction (GR) promotes the highest HeLa cell monolayers destruction (~95%) by trichomonads compared to those grown under high glucose (~44%) condition. Zymography and Western blot using different primary antibodies showed that GR increased the proteolytic activity, amount and secretion of certain CPs, including TvCP2. We further characterized the effect of glucose on TvCP2. TvCP2 increases in GR, localized in vesicles close to the plasma membrane and on the surface ofT. vaginalis. Furthermore, pretreatment of GR-trichomonads with an anti-TvCP2r polyclonal antibody specifically reduced the levels of cytotoxicity and apoptosis induction to HeLa cells in a concentration-dependent manner. In conclusion, our data show that GR, as a nutritional stress condition, promotes trichomonal cytotoxicity to the host cells, increases trichomonad proteolytic activity and amount of CPs, such as TvCP2 involved in cellular damage.
Addressing the constraints of Tritrichomonas foetus sample collection in remote areas: lyophilized modified Diamond's media as a substitute for liquid medium
Authors: Rush Gemma , Reynolds Michael William , Calvani Nichola Eliza Davies , Šlapeta Jan 
Published: March 2019

AbstractBovine trichomoniasis is a notifiable, reproductive disease of cattle caused by the parasite Tritrichomonas foetus. Culturing with modified Diamond's medium (MDM) is required to increase the low number of organisms received from a preputial sample, but is limited in application to remote areas as it requires continuous cold chain storage. This study utilized lyophilization to sustain the viability of MDM during transport in lieu of a continuous cold chain. All lyophilized MDM was able to sustain T. foetus after storage for 42 days at 24 °C, and the results demonstrated that lyophilized MDM was equally as viable as refrigerated liquid MDM. Storage of lyophilized MDM at room temperature for 1 and 7 days did not impact T. foetus yield, both with and without exposure to light. A limitation of the lyophilized MDM was demonstrated with a significant decrease in T. foetus yield when the media was stored at 37 and 58 °C. The lyophilization of MDM provides a robust method of transporting and storing medium prior to reconstitution and inoculation, for use in T. foetus diagnosis and surveillance in remote areas.
Village Reconstruction in Rural China: The Importance of Being Urban
Authors: Wilson Saul , Zhang Xiaorong 
Published: March 2019

AbstractUsing examples from village reconstruction programmes in rural China, we show that local cadres often prioritize project visibility over publicized policy goals. While central policies and the academic literature emphasized land reclamation or rural welfare, local cadres – and the projects they designed – tended instead to focus on projecting an image of urban, wealthy villagers. Where such image-driven behaviour is most deleterious to villagers, it can evince opposition. We observe that some areas avoid conflict by making these projects voluntary or adjusting projects to local conditions. However, we provide a case study of a village with strong village leadership, showing that contrary to recent claims that village cadres are increasingly impotent, some maintain the authority to override widespread objections from villagers.
Seroprevalence of HCV, HBV and HIV in two inner-city London emergency departments
Authors: Cieply L. , Simmons R. , Ijaz S. , Kara E. , Rodger A. , Rosenberg W. , McGuinness A. , Mbisa J. L. , Ledesma J. , Ohemeng-Kumi N. , Dicks S. , Potts H. , Lattimore S. , Mandal S. 
Published: March 2019

AbstractSummary: In this paper we build on work investigating the feasibility of human immunodeficiency virus (HIV) testing in emergency departments (EDs), estimating the prevalence of hepatitis B, C and HIV infections among persons attending two inner-London EDs, identifying factors associated with testing positive in an ED. We also undertook molecular characterisation to look at the diversity of the viruses circulating in these individuals, and the presence of clinically significant mutations which impact on treatment and control.Blood-borne virus (BBV) testing in non-traditional settings is feasible, with emergency departments (ED) potentially effective at reaching vulnerable and underserved populations. We investigated the feasibility of BBV testing within two inner-London EDs. Residual samples from biochemistry for adults (⩾18 years) attending The Royal Free London Hospital (RFLH) or the University College London Hospital (UCLH) ED between January and June 2015 were tested for human immunodeficiency virus (HIV)Ag/Ab, anti-hepatitis C (HCV) and HBsAg. PCR and sequence analysis were conducted on reactive samples. Sero-prevalence among persons attending RFH and UCLH with residual samples (1287 and 1546), respectively, were 1.1% and 1.0% for HBsAg, 1.6% and 2.3% for anti-HCV, 0.9% and 1.6% for HCV RNA, and 1.3% and 2.2% for HIV. For RFH, HBsAg positivity was more likely among persons of blackvs.white ethnicity (odds ratio 9.08; 95% confidence interval 2.72–30), with anti-HCV positivity less likely among females (0.15, 95% CI 0.04–0.50). For UCLH, HBsAg positivity was more likely among non-white ethnicity (13.34, 95% CI 2.20–80.86 (Asian); 8.03, 95% CI 1.12–57.61 (black); and 8.11, 95% CI 1.13–58.18 (other/mixed)). Anti-HCV positivity was more likely among 36–55 year oldsvs.⩾56 years (7.69, 95% CI 2.24–26.41), and less likely among females (0.24, 95% CI 0.09–0.65). Persons positive for HIV-markers were more likely to be of blackvs.white ethnicity (4.51, 95% CI 1.63–12.45), and less likely to have one ED attendance (0.39, 95% CI 0.17–0.88), or female (0.12, 95% CI 0.04–0.42). These results indicate that BBV-testing in EDs is feasible, providing a basis for further studies to explore provider and patient acceptability, referral into care and cost-effectiveness.