bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of Intramural Metastasis in Patients with Esophageal Squamous Cell Carcinoma: An Indicator of Aggressive Cancer Behavior
Authors: Okamura Akihiko , Watanabe Masayuki , Kozuki Ryotaro , Toihata Tasuku , Takahashi Keita , Imamura Yu , Mine Shinji 
Published: April 2019

AbstractBackgroundIntramural metastasis (IM) is occasionally noted in patients with esophageal squamous cell carcinoma (ESCC). However, few recent studies have investigated the clinicopathological characteristics of IM and its survival impact. The present study aimed to clarify the clinicopathological and prognostic significance of IM in patients with ESCC.MethodsWe retrospectively examined 918 consecutive patients who underwent curative intent esophagectomy for ESCC. IM was defined as a pathologically confirmed metastatic lesion, which was clearly separate from the primary tumor and located within the esophageal or gastric wall. The clinicopathological characteristics and survival impact of IM were evaluated. A propensity score‐matched analysis was performed to further elucidate the prognostic impact of IM.ResultsAmong 918 patients, 46 (5.0%) had IM. Advanced tumors were significantly more frequent in patients with IM than in those without IM. The curative resection rate was lower in patients with IM (P = 0.001). Overall survival (OS) and disease‐specific survival (DSS) were worse in patients with IM (both P < 0.001). In multivariate Cox proportional hazard analysis, IM presence was an independent poor prognostic indicator for OS and DSS (both P < 0.001). After propensity score matching, advanced tumors according to pathological N stage and lymphatic invasion were more frequent in patients with IM (P = 0.015 and 0.004, respectively). Additionally, OS and DSS were different between patients with and those without IM (both P = 0.002).ConclusionsIM from ESCC is a local indicator of lymphatic invasion and advanced cancer, as well as an independent factor for poor prognosis.
A phase 2, open-label study of brentuximab vedotin in patients with CD30-expressing solid tumors
Authors: Sharman Jeffrey P. , Wheler Jennifer J. , Einhorn Lawrence , Dowlati Afshin , Shapiro Geoffrey I. , Hilton John , Burke John M. , Siddiqi Tanya , Whiting Nancy , Jalal Shadia I. 
Published: April 2019

Summary
Purpose Brentuximab vedotin (BV) is an anti-CD30 antibody-drug conjugate used in the treatment of several types of lymphomas. Expression of the target antigen has also been reported on a variety of malignant tumors of nonlymphoid origin. This phase 2, open-label study evaluated the safety and antitumor activity of BV in patients with CD30-expressing nonlymphomatous malignancies. Methods Patients were dosed with 1.8 or 2.4 mg/kg BV once every three weeks. Antitumor activity was assessed at Cycles 2, 4, and every 4 cycles thereafter. Patients with stable disease or better were eligible to continue treatment until disease progression, unacceptable toxicity, or study closure. Results Of the 2693 patients screened, 3.8% had solid tumors with CD30 expression and 63 eligible patients with solid tumors enrolled in this study. The most common CD30 positive solid tumors were testicular cancer and mesothelioma. Both subtypes had more than one patient with an objective response. The median duration of BV exposure was 6.1 weeks. The disease control rate, defined as achieving stable disease or better at any point during the study, was 55%. The objective response rate was 11%, with a median duration of response of 2.92 months. The most common adverse events reported were fatigue (57%), nausea (33%), and decreased appetite (32%). Conclusion The safety profile of BV in patients with solid tumors was similar to the known safety profile of BV. In solid tumors, BV had modest activity as a single agent, which was similar to other second-line treatments already available to patients.
Neighborhood Diversity, Neighborhood Affluence: An Analysis of the Neighborhood Destination Choices of Mixed-Race Couples With Children
Authors: Gabriel Ryan , Spring Amy 
Published: April 2019

AbstractPast research has indicated that mixed-race couples with children appear to possess a heightened preference for neighborhoods that are racially and ethnically diverse and relatively affluent so as to reside in areas that are requisitely accepting of, and safe for, their children. However, neighborhoods with higher racial and ethnic diversity tend to be lower in socioeconomic status, implying that some residentially mobile mixed-race couples with children encounter trade-offs between neighborhood diversity and neighborhood affluence in their residential search processes. To investigate this, we apply discrete-choice models to longitudinal data from the Panel Study of Income Dynamics linked to neighborhood-level data from multiple population censuses to compare the neighborhood choices of mixed-race couples with children to those of monoracial couples with children, while assessing how these choices are simultaneously driven by neighborhood diversity and neighborhood affluence. We observe that mixed-race couples with children tend to be more likely to choose higher-diversity neighborhoods than white couples with children, even when neighborhood affluence is allowed to determine the residential choices for these couples. Some higher-income mixed-race couples with children seemingly translate their resources into neighborhoods that are both diverse and affluent.
RULES AND VALUES IN INTERNATIONAL ADJUDICATION: THE CASE OF THE WTO APPELLATE BODY
Authors: Suttle Oisin 
Published: April 2019

AbstractCurrent political challenges facing the WTO Appellate Body raise fundamental questions about the relationship between rules and values in international adjudication. This article applies insights from legal philosophy to identify the role values should play in WTO adjudication. It argues that nothing about the specifics of WTO law would justify excluding values from adjudication; that the doctrinal, political and institutional context of WTO adjudication makes a positivist account of the role of values untenable; but an anti-positivist account requires complementing established economic accounts of WTO law's purpose with an account of fairness and justice in trade and trade regulation.
FORTY YEARS ON: STATE IMMUNITY AND THE STATE IMMUNITY ACT 1978
Authors: Lord Lloyd-Jones  
Published: April 2019

AbstractThis article addresses some of the changes in international law and foreign relations law which have impinged on the operation of the State Immunity Act 1978 in the first 40 years of its operation and some of the ways in which it has been supplemented by judicial decisions. It addresses, in particular, the initial need for legislation in this field, the circumstances in which agents of a State may be entitled to immunity, the relationship between State immunity in domestic law and Article 6 of the European Convention on Human Rights and Article 47 of the EU Charter of Fundamental Rights, the relationship of State immunity and rules of jus cogens, and the respective scope of State immunity and principles of non-justiciability.
Multi-Robot Obstacle Avoidance Based on the Improved Artificial Potential Field and PID Adaptive Tracking Control Algorithm
Authors: Pan Zhenhua , Li Dongfang , Yang Kun , Deng Hongbin 
Published: April 2019

SummaryAs for the obstacle avoidance and formation control for the multi-robot systems, this paper presents an obstacle-avoidance method based on the improved artificial potential field (IAPF) and PID adaptive tracking control algorithm. In order to analyze the dynamics and kinematics of the robot, the mathematical model of the robot is built. Then we construct the motion situational awareness map (MSAM), which can map the environment information around the robot on the MSAM. Based on the MSAM, the IAPF functions are established. We employ the rotating potential field to solve the local minima and oscillations. As for collisions between robots, we build the repulsive potential function and priority model among the robots. Afterwards, the PID adaptive tracking algorithm is utilized to multi-robot formation control. To demonstrate the validity of the proposed method, a series of simulation results confirm that the approaches proposed in this paper can successfully address the obstacle- and collision-avoidance problem while reaching formation.
Nonlinear Optimal Control for the Wheeled Inverted Pendulum System
Authors: Rigatos G. , Busawon K. , Pomares J. , Abbaszadeh M. 
Published: April 2019

SummaryThe article proposes a nonlinear optimal control method for the model of the wheeled inverted pendulum (WIP). This is a difficult control and robotics problem due to the system’s strong nonlinearities and due to its underactuation. First, the dynamic model of the WIP undergoes approximate linearization around a temporary operating point which is recomputed at each time step of the control method. The linearization procedure makes use of Taylor series expansion and of the computation of the associated Jacobian matrices. For the linearized model of the wheeled pendulum, an optimal (H-infinity) feedback controller is developed. The controller’s gain is computed through the repetitive solution of an algebraic Riccati equation at each iteration of the control algorithm. The global asymptotic stability properties of the control method are proven through Lyapunov analysis. Finally, by using the H-infinity Kalman Filter as a robust state estimator, the implementation of a state estimation-based control scheme becomes also possible.
UNDERSTANDING “NO SPECIAL FAVORS”
Authors: Simmons Alicia D. , Bobo Lawrence D. 
Published: April 2019

AbstractDespite its predictive power, there is substantial debate about the attitudes measured by the racial resentment scale (RRS) and the relative weight of each. One group contends that the RRS is a valid measure of racial animus, foregrounding a basic psychological acrimony; some foreground social concerns about group status hierarchies; and yet others assert that the RRS is an invalid measure of racial enmity, instead primarily tapping non-racial principles and politics. We use a multimethod approach to address these debates, mapping the frames of reference respondents use in explaining their RRS answers. We find that the RRS fundamentally measures racial concerns and minimally taps non-racial politics. Although RRS responses reflect psychological acrimony, this orientation is substantially outweighed by social concerns about relative group position. Moreover, RRS responses substantially reflect beliefs about the relevance of race in the contemporary US and the sources of racial inequality, and values about individualism and fairness. We discuss how one of the most potent measures of present-day racial prejudice is rightly understood, and the implications for theory and research at the intersection of race and politics.
Breast milk provides inadequate amounts of vitamin B12 for predominantly breastfed Guatemalan infants
Authors: Anaya-Loyola Miriam A. , Brito Alex , Brown Kenneth H. , Allen Lindsay H. 
Published: April 2019

Abstract. Vitamin B12 (B12) plays in an important role in the development and function of the brain and nervous system, and adequate B12 status is especially important for the normal development of infants. In previous research conducted in Guatemala City we reported a high prevalence of B12 deficiency in lactating women and their infants 3 and 12 months of age, and low B12 concentrations in breast milk. The objective of this study was to assess predictors of serum B12 concentration in predominantly breastfed Guatemalan infants including intake of B12 from breast milk and other foods. Serum B12, breast milk and other food intakes, anthropometry, morbidity and socioeconomic status were assessed in infants 6.7 ± 0.6 months of age (n = 127, 52% female) in peri-urban Guatemala City. Twenty-four percent of infants had deficient B12 status (serum B12 concentration < 148 pmol/L) and 37% had marginal B12 status (148–220 pmol/L). Serum B12 concentrations were negatively correlated with infants’ consumption of energy from breast milk (r = −0.37, p = 0.001), and positively correlated with their total consumption of animal source foods, especially cow’s milk (r = 0.40, p = 0.001). Based on previously analyzed breast milk B12 concentrations in a nearby community, breast milk provided < 10% of the recommended daily B12 intake for this age. We conclude that there was a high prevalence of B12 deficiency in these Guatemalan infants by 6 months of age. Serum B12 was higher in infants consuming more cow’s milk and lower in those consuming more breast milk.
Modeling Energetic Electron Nonlinear Wave‐Particle Interactions With Electromagnetic Ion Cyclotron Waves
Authors: Zheng Liheng , Chen Lunjin , Zhu Hui 
Published: April 2019

AbstractElectromagnetic ion cyclotron (EMIC) waves in duskside plasmasphere and plasmaspheric plume scatter megaelectron volt electrons into the loss cone and are considered a major loss mechanism for the outer radiation belt. Wave‐particle interaction between energetic electrons and EMIC waves has been studied extensively by the quasi‐linear diffusion theory. However, EMIC waves are typically strong enough to trigger nonlinear wave‐particle interaction effects and transport electrons in very different ways from quasi‐linear diffusion. New mathematical method is therefore in demand to study the evolution of energetic electron distribution in response to nonlinear wave‐particle interaction. In this work, we present a Markov chain description of the wave‐particle interaction process, in which the electron distribution is represented by a state vector and is evolved by the Markov matrix. The Markov matrix is a matrix form of the electron response Green's function and could be determined from test particle simulations. Our modeling results suggest that electron loss rate is not significantly affected by phase bunching and phase trapping, but for strong EMIC waves, electron distribution is more saturated near loss cone than quasi‐linear theory prediction, and negative electron phase space density slope develops inside loss cone.
Aerosolization of Crude Oil‐Dispersant Slicks Due to Bubble Bursting
Authors: Sampath Kaushik , Afshar‐Mohajer Nima , Chandrala Lakshmana D. , Heo Won‐Seok , Gilbert Joshua , Austin David , Koehler Kirsten , Katz Joseph 
Published: April 2019

AbstractBubble bursting is a primary source of marine aerosols, yet little is known about particle emissions due to the bubble bursting in slicks containing oil‐dispersant mixtures. In this study, bubbles with mode sizes of 86 μm (denoted as small), 178 μm (medium), and 595 μm (large) are injected into a seawater column covered by slicks of crude oil, pure dispersant, and dispersant premixed with oil at a ratio of 1:25. The aerosol size distributions are monitored in the 0.5‐ to 20‐μm and 10‐ to 380‐nm ranges both in clean and ambient air environments. In ambient air, a tenfold increase in submicron particle concentration occurs when large bubbles burst on slicks of 500‐μm dispersant premixed with oil at a ratio of 1:25 oil or 50‐μm pure dispersant. Yet, in multiple tests performed at different ambient particle concentrations, the elevated size distributions persistently maintain the same shape as that of the ambient air. In contrast, smaller bubbles and tests not involving dispersants do not cause such an increase. Nanodroplets are also generated by large bubbles in particle‐free air, but their concentrations are much lower. All plumes generate micron‐sized aerosols, but trends vary. For the same contaminant, the microdroplet concentration decreases with increasing slick thickness. Particularly striking is a reduction of 2 orders of magnitude in the microdroplet concentration when medium and small bubbles burst on 500‐μm crude oil slicks. Chemical analysis of air and particulates collected from filters sampling the particles confirms the presence of airborne oil above the slicks.
Numerical Simulation of Midlatitude Upper‐Level Zonal Wind Response to the Change of North Pacific Subtropical Front Strength
Authors: Chen Qiuyu , Hu Haibo , Ren Xuejuan , Yang Xiu‐Qun 
Published: April 2019

AbstractUsing the Weather Research and Forecasting model, numerical experiments with reconstructed ideal zonally uniform sea surface temperatures were designed to discuss the midlatitude upper‐level zonal wind response to the change of subtropical front strength over the North Pacific in winter. The results show that the enhancement of the subtropical frontal zone (STFZ) of the North Pacific leads to the stronger upper zonal wind, without considering the lateral boundary barotropic and baroclinic disturbances in this regional model. The enhanced STFZ first results in positive meridional temperature gradient anomalies by affecting the sea surface sensible heat flux. Then the low‐level wind increases because of the increased thermal wind. In addition, the temperature gradient anomalies spread to middle and upper troposphere by baroclinic waves, causing the increase of Eady growth rate and enhanced storm tracks on the southern side of the STFZ and the decrease on the northern side. The strengthened storm tracks give rise to a stronger midlatitude westerly jet accompanied with a southward movement through wave‐mean flow interaction, including both barotropical energy conversion and the Rossby wave breaking.
Optical Properties of Laboratory and Ambient Biomass Burning Aerosols: Elucidating Black, Brown, and Organic Carbon Components and Mixing Regimes
Authors: Romonosky Dian E. , Gomez Samantha L. , Lam Jared , Carrico Christian M. , Aiken Allison C. , Chylek Petr , Dubey Manvendra K. 
Published: April 2019

AbstractBiomass burning (BB) is an important global source of aerosol and trace gases that degrade air quality, decrease visibility, and impact climate and human health. Refractory black carbon (rBC), brown carbon (BrC), and organic aerosol are major components of BB emissions. BB aerosol composition is highly variable at the source and depends on fuel composition and combustion phase. Atmospheric aging alters fresh BB aerosol through processes that are complex and dynamic. To better understand the variability in optical properties, we report fresh aerosol laboratory measurements from burning southwestern U.S. fuels and compare them to aged ambient BB aerosol from wildfires over a range of atmospheric time scales. Our BB aerosol analysis uses the relationship between the absorption Ångström exponent and single‐scattering albedo (SSA) to identify rBC, BrC, and organic aerosol‐dominated regimes that are defined using Mie theory. This model framework is used to interpret the large variability in optical properties measured in laboratory burns. In contrast, we find the observed absorption Ångström exponent‐SSA relationship for ambient BB aerosol to be less variable and more clustered together with increased atmospheric aging. This transition from fresh to aged behavior is attributed to the homogenization of the BB aerosol from mixing and aging over several hours. Finally, BB aerosol in ambient fire plumes that have aged for several hours exhibits larger SSAs than laboratory flaming burns. We conclude that BrC/OC mixtures play a larger role than rBC in the positive climate forcing of BB aerosol than what would be projected from laboratory results.
Extreme Weather, Chemical Facilities, and Vulnerable Communities in the U.S. Gulf Coast: A Disastrous Combination
Authors: Anenberg Susan C. , Kalman Casey 
Published: April 2019

AbstractMany chemical facilities are located in low‐lying coastal areas and vulnerable to damage from hurricanes, flooding, and erosion, which are increasing with climate change. Extreme weather can trigger industrial disasters, including explosions, fires, and major chemical releases, as well as chronic chemical leakage into air, water, and soil. We identified 872 highly hazardous chemical facilities within 50 miles of the hurricane‐prone U.S. Gulf Coast. Approximately 4,374,000 people, 1,717 schools, and 98 medical facilities were within 1.5 miles of these facilities. Public health risks from colocated extreme weather, chemical facilities, and vulnerable populations are potentially disastrous and growing under climate change.
Abnormal development of early auditory processing in 22q11.2 Deletion Syndrome
Authors: Cantonas Lucia-Manuela , Tomescu Miralena I. , Biria Marjan , Jan Reem K. , Schneider Maude , Eliez Stephan , Rihs Tonia A. , Michel Christoph M. 
Published: April 2019

AbstractThe 22q11.2 Deletion Syndrome (22q11.2 DS) is one of the highest genetic risk factors for the development of schizophrenia spectrum disorders. In schizophrenia, reduced amplitude of the frequency mismatch negativity (fMMN) has been proposed as a promising neurophysiological marker for progressive brain pathology. In this longitudinal study in 22q11.2 DS, we investigate the progression of fMMN between childhood and adolescence, a vulnerable period for brain maturation. We measured evoked potentials to auditory oddball stimuli in the same sample of 16 patients with 22q11.2 DS and 14 age-matched controls in childhood and adolescence. In addition, we cross-sectionally compared an increased sample of 51 participants with 22q11.2 DS and 50 controls divided into two groups (8–14 and 14–20 years). The reported results are obtained using the fMMN difference waveforms. In the longitudinal design, the 22q11.2 deletion carriers exhibit a significant reduction in amplitude and a change in topographic patterns of the mismatch negativity response from childhood to adolescence. The same effect, reduced mismatch amplitude in adolescence, while preserved during childhood, is observed in the cross-sectional study. These results point towards functional changes within the brain network responsible for the fMMN. In addition, the adolescents with 22q11.2 DS displayed a significant increase in amplitude over central electrodes during the auditory N1 component. No such differences, reduced mismatch response nor increased N1, were observed in the typically developing group. These findings suggest different developmental trajectories of early auditory sensory processing in 22q11.2 DS and functional changes that emerge during the critical period of increased risk for schizophrenia spectrum disorders.
Primed histone demethylation regulates shoot regenerative competency
Authors: Ishihara Hiroya , Sugimoto Kaoru , Tarr Paul T. , Temman Haruka , Kadokura Satoshi , Inui Yayoi , Sakamoto Takuya , Sasaki Taku , Aida Mitsuhiro , Suzuki Takamasa , Inagaki Soichi , Morohashi Kengo , Seki Motoaki , Kakutani Tetsuji , Meyerowitz Elliot M. , Matsunaga Sachihiro 
Published: April 2019

AbstractAcquisition of pluripotency by somatic cells is a striking process that enables multicellular organisms to regenerate organs. This process includes silencing of genes to erase original tissue memory and priming of additional cell type specification genes, which are then poised for activation by external signal inputs. Here, through analysis of genome-wide histone modifications and gene expression profiles, we show that a gene priming mechanism involving LYSINE-SPECIFIC DEMETHYLASE 1-LIKE 3 (LDL3) specifically eliminates H3K4me2 during formation of the intermediate pluripotent cell mass known as callus derived from Arabidopsis root cells. While LDL3-mediated H3K4me2 removal does not immediately affect gene expression, it does facilitate the later activation of genes that act to form shoot progenitors when external cues lead to shoot induction. These results give insights into the role of H3K4 methylation in plants, and into the primed state that provides plant cells with high regenerative competency.