bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis of transcriptomics and radiomics revealed the potential of TEDC2 as a diagnostic marker for lung adenocarcinoma
Authors: Huang Qian , Zhang Peng , Guo Zhixu , Li Min , Tao Chao , Yu Zongyang 
Published: November 2024

Background
Lung adenocarcinoma (LUAD) is a widely occurring cancer with a high death rate. Radiomics, as a high-throughput method, has a wide range of applications in different aspects of the management of multiple cancers. However, the molecular mechanism of LUAD by combining transcriptomics and radiomics in order to probe LUAD remains unclear.

Methods
The transcriptome data and radiomics features of LUAD were extracted from the public database. Subsequently, we used weighted gene co-expression network analysis (WGCNA) and a series of machine learning algorithms including Random Forest (RF), Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression, and Support Vector Machines Recursive Feature Elimination (SVM-RFE) to proceed with the screening of diagnostic genes for LUAD. In addition, the CIBERSORT and ESTIMATE algorithms were utilized to assess the association of these genes with immune profiles. The LASSO algorithm further identified the features most relevant to the expression levels of LUAD diagnostic genes and validated the model based on receiver operating characteristic (ROC), precision-recall (PR), calibration curves and decision curve analysis (DCA) curves. Finally, RT-qPCR, transwell and cell counting kit-8 (CCK8) based assays were performed to assess the expression levels and potential functions of the screened genes in LUAD cell lines.

Results
We screened a total of 214 modular genes with the highest correlation with LUAD samples based on WGCNA, of which 192 genes were shown to be highly expressed in LUAD patients. Subsequently, three machine learning algorithms identified a total of four genes, including UBE2T, TEDC2, RCC1, and FAM136A, as diagnostic molecules for LUAD, and the ROC curves showed that these diagnostic molecules had good diagnostic performance (AUC values of 0.989, 0.989, 989, and 0.987, respectively). The expression of these diagnostic molecules was significantly higher in tumor samples than in normal para-cancerous tissue samples and also correlated significantly and negatively with stromal and immune scores. Specifically, we also constructed a model based on TEDC2 expression consisting of seven radiomic features. Among them, the ROC and PR curves showed that the model had an AUC value of up to 0.96, respectively. Knockdown of TEDC2 slowed down the proliferation, migration and invasion efficiency of LUAD cell lines.

Conclusion
In this study, we screened for diagnostic markers of LUAD and developed a non-invasive radiomics model by innovatively combining transcriptomics and radiomics data. These findings contribute to our understanding of LUAD biology and offer potential avenues for further exploration in clinical practice.
Risk for Herpes Zoster in Tofacitinib‐Treated Rheumatoid Arthritis Patients With and Without Concomitant Methotrexate and Glucocorticoids
Authors: Curtis Jeffrey R. , Xie Fenglong , Yang Shuo , Bernatsky Sasha , Chen Lang , Yun Huifeng , Winthrop Kevin 
Published: October 2018

ObjectiveIncreased incidence of herpes zoster (HZ) has been observed with JAK inhibitors such as tofacitinib. However, whether concomitant methotrexate (MTX) and/or glucocorticoids confer additional (additive or multiplicative) risk is unclear. We evaluated HZ risk in tofacitinib users with and without MTX and glucocorticoids.MethodsWithin MarketScan and Medicare data (2011–2016), we identified all patients with rheumatologist‐diagnosed rheumatoid arthritis initiating treatment with tofacitinib (index date); demographics and baseline covariates were evaluated in the year prior to the index date. HZ was ascertained using International Classification of Diseases, Ninth Revision or Tenth Revision codes with antiviral drug use (±7 days). Multivariable Cox regression was used to evaluate hazard ratios (HRs) for HZ in tofacitinib users with and without current concomitant MTX and glucocorticoids, controlling for baseline covariates.ResultsWe studied 8,030 new tofacitinib users (83.3% women). The mean ± SD age was 60.3 ± 12.6 years. HZ incidence in tofacitinib users was numerically lowest in the absence of glucocorticoids (3.4 per 100 patient‐years with MTX; 3.7 per 100 patient‐years without MTX). An approximately 2‐fold increased incidence of HZ was observed for tofacitinib users receiving either glucocorticoids alone (6.0 per 100 patient‐years) or both MTX plus glucocorticoids (6.5 per 100 patient‐years). The adjusted HR for HZ in tofacitinib users was unchanged (HR 0.99 [95% confidence interval (95% CI) 0.64–1.54]) when given only with MTX, but was increased (HR 1.96 [95% CI 1.33–2.88]) for tofacitinib plus glucocorticoids. Older age and female sex were also risk factors, while prior vaccination was associated with a strong trend for lower risk.ConclusionIn tofacitinib users, HZ occurred at a rate of approximately 4% per year and was further doubled with glucocorticoid exposure. Concomitant MTX did not confer additional risk. Zoster vaccination may decrease risk.
Sex‐Specific Influence of Quadriceps Weakness on Worsening Patellofemoral and Tibiofemoral Cartilage Damage: A Prospective Cohort Study
Authors: Culvenor Adam G. , Segal Neil A. , Guermazi Ali , Roemer Frank , Felson David T. , Nevitt Michael C. , Lewis Cora E. , Stefanik Joshua J. 
Published: October 2018

ObjectiveReports on quadriceps weakness as a risk factor for incident and progressive knee osteoarthritis are conflicting, potentially due to differing effects of muscle strength on patellofemoral and tibiofemoral compartments. This study aimed to examine the sex‐specific relation of quadriceps strength to worsening patellofemoral and tibiofemoral cartilage damage over 84 months.MethodsThe Multicenter Osteoarthritis Study is a cohort study of individuals with or at risk for knee osteoarthritis. Maximal quadriceps strength was assessed at baseline. Cartilage damage was semiquantitatively assessed by magnetic resonance imaging at baseline and 84‐month follow‐up using the Whole‐Organ Magnetic Resonance Imaging Score (WORMS). Worsening patellofemoral and tibiofemoral cartilage damage was defined as any WORMS score increase in each subregion within medial and lateral compartments separately. Logistic regression with generalized estimating equations was used to assess the sex‐specific relation of quadriceps strength to worsening cartilage damage.ResultsA total of 1,018 participants (mean ± SD age 61 ± 8 years, and mean ± SD body mass index 29.3 ± 4.5 kg/m2; 64% female) were included. Quadriceps weakness increased the risk of worsening lateral patellofemoral cartilage damage in women (risk ratio for lowest versus highest quartile of strength 1.50 [95% confidence interval 1.03–2.20]; P = 0.007 for linear trend) but not in men. There was generally no association between quadriceps weakness and worsening cartilage damage in the medial or lateral tibiofemoral compartment for either women or men.ConclusionLow quadriceps strength increased the risk of worsening cartilage damage in the lateral patellofemoral joint of women, suggesting that optimizing quadriceps strength may help prevent worsening of structural damage in the patellofemoral joint in women.
Using Physical Activity Trackers in Arthritis Self‐Management: A Qualitative Study of Patient and Rehabilitation Professional Perspectives
Authors: Leese Jenny , Macdonald Graham G. , Tran Bao Chau , Wong Rosalind , Backman Catherine L. , Townsend Anne F. , Davis Aileen M. , Jones C. Allyson , Gromala Diane , Avina‐Zubieta J. Antonio , Hoens Alison M. , Li Linda C. 
Published: October 2018

ObjectiveTo compare and contrast the perspectives of patients with arthritis and those of rehabilitation professionals regarding starting and sustaining use of physical activity trackers (PATs).MethodsWe conducted focus group sessions with patients, physiotherapists, and occupational therapists in Ontario, Alberta, or British Columbia, Canada. To be eligible, patients must have self‐reported a diagnosis of inflammatory or osteoarthritis. Rehabilitation professionals reported that at least 40% of their caseload was dedicated to arthritis care. Participants had any level of experience with PATs. A thematic analytic approach was used.ResultsThe following 3 themes were identified: 1) anticipating sharing objective measures of physical activity. Participants agreed that use of PATs had the potential to improve consultations between patients with arthritis and rehabilitation professionals but were uncertain how to achieve this potential; 2) perceived or experienced barriers to start or continue using a PAT. Participants shared doubts about whether existing PATs would meet specific needs of patients with arthritis and expressed concerns about possible negative impacts; and 3) bolstering motivation? Although there was agreement that use of PATs could bolster the motivation of patients who were already active, patients and rehabilitation professionals had different opinions regarding whether use of PATs alone would motivate patients to start increasing activity levels.ConclusionOur study highlights similarities and differences between the perspectives of patients and rehabilitation professionals regarding the potential value and risks of integrating PATs into arthritis self‐management. Despite agreement about the potential of PATs, participants were uncertain how to effectively incorporate these tools to enhance patient–clinician consultations and had differing views about whether use of PATs would support a patient's motivation to be active.
Silk Fibroin Microparticles with Hollow Mesoporous Silica Nanocarriers Encapsulation for Abdominal Wall Repair
Authors: Zhao Xin , Chen Zhuoyue , Liu Yuxiao , Huang Qian , Zhang Huidan , Ji Wu , Ren Jianan , Li Jieshou , Zhao Yuanjin 
Published: October 2018

AbstractTherapeutic vascularization appears to be an effective way of repairing abdominal wall defects. Attempts to implement this treatment tend to focus on the generation of featured drug carriers with the ability effectively to encapsulate the angiogenesis‐stimulating agents and control their release to maintain an appropriate concentration at the injured area. Here, a new type of composite microparticle (CM) composed of silk fibroin (SF) and hollow mesoporous silica nanocarriers (HMSNs) is presented for therapeutic agent delivery. The CMs are generated by drying microfluidic emulsion templates of HMSN‐dispersed SF solution. The resultant CMs have a distinctive micro‐nanostructure, in which two barriers control the drug release. The encapsulated HMSNs increase the drug‐carrying capacity of the CMs, and also form the first barrier via physical absorption. The microfluidic SF microparticles not only provide a shell with excellent monodispersity and biocompatibility but also form the second barrier via efficient encapsulation. Because of these superior properties of the CMs, the loaded drugs can be delivered with a satisfactory activity at the required rate, making them ideal for implementing therapeutic vascularization and repairing abdominal wall defects.
Piezoelectric Biomaterials for Sensors and Actuators
Authors: Chorsi Meysam T. , Curry Eli J. , Chorsi Hamid T. , Das Ritopa , Baroody Jeffrey , Purohit Prashant K. , Ilies Horea , Nguyen Thanh D. 
Published: October 2018

AbstractRecent advances in materials, manufacturing, biotechnology, and microelectromechanical systems (MEMS) have fostered many exciting biosensors and bioactuators that are based on biocompatible piezoelectric materials. These biodevices can be safely integrated with biological systems for applications such as sensing biological forces, stimulating tissue growth and healing, as well as diagnosing medical problems. Herein, the principles, applications, future opportunities, and challenges of piezoelectric biomaterials for medical uses are reviewed thoroughly. Modern piezoelectric biosensors/bioactuators are developed with new materials and advanced methods in microfabrication/encapsulation to avoid the toxicity of conventional lead‐based piezoelectric materials. Intriguingly, some piezoelectric materials are biodegradable in nature, which eliminates the need for invasive implant extraction. Together, these advancements in the field of piezoelectric materials and microsystems can spark a new age in the field of medicine.
The Role of Surface Recombination on the Performance of Perovskite Solar Cells: Effect of Morphology and Crystalline Phase of TiO2 Contact
Authors: Idígoras Jesús , Contreras‐Bernal Lidia , Cave James M. , Courtier Nicola E. , Barranco Ángel , Borras Ana , Sánchez‐Valencia Juan R. , Anta Juan A. , Walker Alison B. 
Published: October 2018

AbstractHerein, the preparation of 1D TiO2 nanocolumnar films grown by plasma‐enhanced chemical vapor deposition is reported as the electron selective layer (ESL) for perovskite solar devices. The impact of the ESL architecture (1D and 3D morphologies) and the nanocrystalline phase (anatase and amorphous) is analyzed. For anatase structures, similar power conversion efficiencies are achieved using an ESL either the 1D nanocolumns or the classical 3D nanoparticle film. However, lower power conversion efficiencies and different optoelectronic properties are found for perovskite devices based on amorphous 1D films. The use of amorphous TiO2 as electron selective contact produces a bump in the reverse scan of the current–voltage curve as well as an additional electronic signal, detected by impedance spectroscopy measurements. The dependence of this additional signal on the optical excitation wavelength used in the IS experiments suggests that it stems from an interfacial process. Calculations using a drift‐diffusion model which explicitly considers the selective contacts reproduces qualitatively the main features observed experimentally. These results demonstrate that for a solar cell in which the contact is working properly the open‐circuit photovoltage is mainly determined by bulk recombination, whereas the introduction of a “bad contact” shifts the balance to surface recombination.
Controllable Sandwiching of Reduced Graphene Oxide in Hierarchical Defect‐Rich MoS2 Ultrathin Nanosheets with Expanded Interlayer Spacing for Electrocatalytic Hydrogen Evolution Reaction
Authors: Shah Sayyar Ali , Zhu Guoxing , Shen Xiaoping , Kong Lirong , Ji Zhenyuan , Xu Keqiang , Zhou Hongbo , Zhu Jun , Song Peng , Song Chunsen , Yuan Aihua , Miao Xuli 
Published: October 2018

AbstractThe successful designing of low‐cost and highly active electrocatalytic materials from earth‐abundant elements are favorable for the large scale production of hydrogen from water splitting. Herein, the controllable sandwiching of reduced graphene oxide (RGO) in hierarchical defect‐rich MoS2 ultrathin nanosheets (MoSGMoS) with vertical alignment and expanded interlayer spacing is synthesized by hydrothermal method. The MoSGMoS product exhibits outstanding electrocatalytic activity for hydrogen evolution reaction (HER) with an onset overpotential of 24.3 mV, low overpotentials of 72 mV at 10 mA cm−2 and 384 mV at 1300 mA cm−2, a small Tafel slope of 44.7 mV decade−1, large exchange current density of 0.67 mA cm−2, and high durability in H2SO4 solution. The HER performance of the MoSGMoS catalyst is much better than most of the reported MoS2‐based catalysts, especially in terms of onset overpotential and cathodic current density. The synergistic effect between defect‐rich MoS2 ultrathin nanosheets with hierarchical structure, vertical alignment and expanded interlayer spacing, and conductive RGO is responsible for the outstanding HER activity. This method may open a new way to grow hierarchical MoS2 nanosheets on carbonaceous materials for enhanced hydrogen production from water splitting.
A Trisymmetric Magnetic Microchip Surface for Free and Two‐Way Directional Movement of Magnetic Microbeads
Authors: Sajjad Umer , Lage Enno , McCord Jeffrey 
Published: October 2018

AbstractThe guidance of labeled microcarriers in microfluidic environments is a prerequisite to the development of magnetic pattern assisted lab‐on‐chip technology. Square wave modulations of in‐plane applied magnetic fields enable the forward and backward locomotion of superparamagnetic microspheres on discrete hexagonally arranged ferromagnetic structures in a flowless microfluidic environment at a single bead level. By using distinct magnetic field sequences, selective directional transportation and two‐way separational motion of different ensembles of beads across a varying stray magnetic field pattern is achieved. Microbeads can be moved along different directions along spatial microcorridors. The demonstrated realization of multifunctional patterned magnetic surfaces enables the controlled positioning and sorting of mixed populations of functionalized microcarriers for biodiagnostic applications.
Intrinsic Behavior of CH3NH3PbBr3 Single Crystals under Light Illumination
Authors: Ecker Benjamin R. , Wang Congcong , Wei Haotong , Yuan Yongbo , Huang Jinsong , Gao Yongli 
Published: October 2018

AbstractSingle crystal CH3NH3PbBr3 samples are exposed to light illumination, with a light intensity about seven times stronger than the sun while under ultrahigh vacuum (UHV) conditions, in order to investigate their chemical and structural stability from prolonged light illumination. X‐ray photoemission spectroscopy measurements show that within 10 h of illumination, about half of the initial C, N, and Br elemental concentrations leave the surface and about half of the perovskite's Pb is converted into metallic Pb. Light exposures while in the UHV system also significantly roughen the surface, and surprisingly, empty voids form ≈1 to 3 µm down in the light exposed region. A framework based on the Kirkendall effect is put forward to explain the observed void formation. This proposed model may be relevant to the slow degradation of perovskite solar cells, which is sometimes attributed to irreversible chemical reactions from undesired diffusion. These measurements and observations reveal the intrinsic behavior of the CH3NH3PbBr3 single crystals under light illumination while in a UHV system where volatile species are free to leave, in contrast to existing device studies on the photostability of perovskite solar cells.
Efficient Visible–Near‐Infrared Hybrid Perovskite:PbS Quantum Dot Photodetectors Fabricated Using an Antisolvent Additive Solution Process
Authors: Zhao Dan , Huang Jiang , Qin Ruiheng , Yang Genjie , Yu Junsheng 
Published: October 2018

AbstractOrganometal lead‐halide perovskites demonstrate excellent photovoltaic performance in the visible (Vis) region. However, their lack of response in the near‐infrared (NIR) region limits their applications in broadband photodetectors. Herein, an efficient Vis–NIR perovskite photodetector (PePD) created by doping PbS quantum dots (QDs) in perovskite precursors via an antisolvent additive solution process is reported. By changing the volume of the antisolvent additive, perovskite hybrid films of MAPbI3:PbS QDs with good crystallinity and uniform grain size are created. The resultant Vis–NIR PePD exhibits a specific detectivity of 1012 and 1011 Jones in the visible and NIR regions, respectively. These results suggest that the antisolvent additive solution process can disperse PbS QDs between perovskite grain boundaries and control the perovskite crystallinity and morphology, providing a simple method to broaden the spectral response range of PePDs.
Biocatalytic N‐Acylation of Amines in Water Using an Acyltransferase from Mycobacterium smegmatis
Authors: Contente Martina Letizia , Pinto Andrea , Molinari Francesco , Paradisi Francesca 
Published: October 2018

AbstractA straightforward one‐step biocatalyzed synthesis of different N‐acyl amides in water was accomplished using the versatile and chemoselective acyltransferase from Mycobacterium smegmatis (MsAcT). Acetylation of primary arylalkyl amines was achieved with a range of acetyl donors in biphasic systems within 1 hour and at room temperature. Vinyl acetate was the best donor which could be employed in the N‐acetylation of a large range of primary amines in excellent yields (85–99%) after just 20 minutes. Other acyl donors (including formyl‐, propionyl‐, and butyryl‐donors) were also efficiently employed in the biocatalytic N‐acylation. Finally, the biocatalyst was tested in transamidation reactions using acetamide as acetyl donor in aqueous medium, reaching yields of 60–70%. This work expands the toolbox of preparative methods for the formation of N‐acyl amides, describing a biocatalytic approach easy to accomplish under mild conditions in water.magnified image
Stiffness‐Independent Toughening of Beams through Coaxial Interfaces
Authors: Mueller Jochen , Raney Jordan R. , Kochmann Dennis M. , Shea Kristina 
Published: October 2018

AbstractTo be of engineering relevance, it is essential for stiff and strong materials to possess also high toughness. However, as these properties are typically mutually exclusive, they are rarely found in nature and synthetic replications are extremely limited. Here, an elegant albeit simple physical principle that enables ligaments in cellular networks to possess these mechanical properties simultaneously is presented. The underlying architecture consists of multiple, coaxially aligned layers separated by interfaces that prevent crack propagation, hence increasing the energy required for complete rupture. The results show that the fracture strain and toughness can be increased by over 100%, when compared to conventional reference struts, while fully maintaining the density, stiffness, and strength. The bioinspired and highly versatile approach is scale‐independent under the absence of shear, applicable to various geometries, and complementary to existing approaches. It can, therefore, significantly improve safety and reduce cost and environmental impact in numerous applications, such as packaging, sports equipment, and transportation.
Self‐Supporting Porous CoP‐Based Films with Phase‐Separation Structure for Ultrastable Overall Water Electrolysis at Large Current Density
Authors: Yu Xiangtao , Wang Mingyong , Gong Xuzhong , Guo Zhancheng , Wang Zhi , Jiao Shuqiang 
Published: October 2018

AbstractStable non‐noble metal electrocatalysts are of essential importance for industrial water electrolysis. Powdery electrocatalysts loaded on current collectors by binders are often designed, but easily fall off due to strong attack by bubbles at an industrial large current density (>400 mA cm−2). A novel strategy is developed to construct a self‐supported dual‐phase porous Co2P–Co3O4 film for oxygen evolution reaction (OER) and micro‐nanoporous Co2P film for hydrogen evolution reaction (HER) based on the electrodeposition of single‐phase porous CoP film on gas–liquid–solid interface, phase separation to Co2P–Co, and selective oxidation/etching of the Co phase. The self‐supported dual‐phase Co2P–Co3O4 catalyst exhibits good electrocatalytic activity for OER. The overpotentials are 265 and 405 mV at 20 and 200 mA cm−2, respectively. In addition, the self‐supported micro‐nanoporous Co2P catalyst shows high catalytic activity for HER due to large active area and good wettability. Both dual‐phase Co2P–Co3O4 and micro‐nanoporous Co2P possess ultrastability, even at a large current density of 500 mA cm−2 due to the self‐supported structure. The cell voltage of water electrolysis using a self‐supported Co2P–Co3O4||Co2P electrolyzer at 500 mA cm−2 is only about 3.36 ± 0.01 V, which is much lower than that (4.31 ± 0.05 V) of the IrO2–Ta2O5||Pt electrolyzer.