bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of poor sleep quality in elderly patients with diabetes mellitus, hyperlipidemia and hypertension in Singapore
Authors: Chiang Grace S. H. , Sim Brenda L. H. , Lee Jeannette J. M. , Quah Joanne H. M. 
Published: March 2018

AbstractAimThe objective of this study was to assess determinants of poor sleep quality which is an under-diagnosed and under-treated problem in elderly patients with diabetes mellitus, hyperlipidemia and hypertension.BackgroundPoor sleep quality is linked to decreased quality of life, increased morbidity and mortality. Poor sleep quality is common in the elderly population with associated cardiometabolic risk factors such as diabetes, hyperlipidemia and hypertension.MethodsThis is a cross-sectional study undertaken in the primary healthcare setting (Singhealth Polyclinics-Outram) in Singapore. Singaporeans aged 65 years and above who had at least one of the three cardiometabolic risk factors (diabetes, hypertension and hyperlipidemia) were identified. Responders’ sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire and were divided into those with good quality sleep and those with poor quality sleep, based on the PSQI score. Information on demographics, co-morbidities and lifestyle practices were collected. Descriptive and multivariate analyses of determinants of poor sleep were determined.FindingsThere were 199 responders (response rate 88.1%). Nocturia (adjusted prevalence rate ratio 1.54, 95% confidence interval 1.06–2.26) was found to be associated with an increased risk of poor sleep quality in elderly patients with diabetes mellitus, hypertension and hyperlipidaemia. Nocturia, a prevalent problem in the Asian elderly population, has been found to be associated with poor sleep quality in our study. Hence, it is imperative to identify and treat patients with nocturia to improve sleep quality among them.
Amygdala – and serum – neurotrophic factor levels depend on rearing condition in male rats
Authors: Babri S. , Mohaddes G. , Mosaferi B. 
Published: March 2018

AbstractEarly life experiences could determine brain and behavioral development. Neurotrophic factors are likely to mediate the effects of the experience on brain structures and function. Brain-derived neurotrophic factor (BDNF) plays a central role in psychiatric disorders. To investigate the effects of early rearing condition on the amygdala – and serum – BDNF levels, we reared male Wistar rats from weaning (postnatal days 21) to adulthood (postnatal days 119) in three different rearing conditions: (1) enriched, (2) standard and (3) isolated. We found that long-term post-weaning environmental enrichment leads to lower amygdala – and serum – BDNF levels as well as lower brain weights. Grouped rearing in standard laboratory cages enhanced body weight. Thus, early rearing condition might play a crucial role in adult healthiness by predetermining individual BDNF profiles.
Phenology of Five Palmer amaranth (Amaranthus palmeri) Populations Grown in Northern Indiana and Arkansas
Authors: Spaunhorst Douglas J. , Devkota Pratap , Johnson William G. , Smeda Reid J. , Meyer Christopher J. , Norsworthy Jason K. 
Published: March 2018

AbstractPalmer amaranth (Amaranthus palmeriS. Watson) is a problematic weed encountered in U.S. cotton (Gossypium hirsutumL.) and soybean [Glycine max(L.) Merr.] production, with infestations spreading northward. This research investigated the influence of planting date (early, mid-, and late season) and population (AR, IN, MO, MS, NE, and TN) onA. palmerigrowth and reproduction at two locations. All populations planted early or midseason at Throckmorton Purdue Agricultural Center (TPAC) and Arkansas Agriculture Research and Extension Center (AAREC) measured 196 and 141 cm or more, respectively. Amaranthus palmeriheight did not exceed 168 and 134 cm when planted late season at TPAC and AAREC, respectively. Early season plantedA. palmerifrom NE grew to 50% of maximum height 8 to 13 d earlier than all other populations under TPAC conditions. In addition, the NE population planted early, mid-, and late season achieved 50% inflorescence emergence 5, 4, and 6 d earlier than all other populations, respectively. All populations established at TPAC produced fewer than 100,000 seeds plant−1. No population planted at TPAC and AAREC produced more than 740 and 1,520 g plant−1of biomass at 17 and 19 wk after planting, respectively. Planting date influenced the distribution of male and female plants at TPAC, but not at AAREC. Amaranthus palmerifrom IN and MS planted late season had male-to-female plant ratios of 1.3:1 and 1.7:1, respectively. Amaranthus palmeriintroduced to TPAC from NE can produce up to 7,500 seeds plant−1if emergence occurs in mid-July. An NEA. palmeripopulation exhibited biological characteristics allowing it to be highly competitive if introduced to TPAC due to a similar latitudinal range, but was least competitive when introduced to AAREC. AlthoughA. palmerioriginating from different locations can vary biologically, plants exhibited environmental plasticity and could complete their life cycle and contribute to spreading populations.
The dynamically selected stellar halo of the Galaxy withGaiaand the tilt of the velocity ellipsoid
Authors: Posti Lorenzo , Helmi Amina , Veljanoski Jovan , Breddels Maarten A. 
Published: March 2018

Aims.We study the dynamical properties of halo stars located in the solar neighbourhood. Our goal is to explore how the properties of the halo depend on the selection criteria used to define a sample of halo stars. Once this is understood, we proceed to measure the shape and orientation of the halo’s velocity ellipsoid and we use this information to put constraints on the gravitational potential of the Galaxy.Methods.We use the recently releasedGaiaDR1 catalogue cross-matched to the RAVE dataset for our analysis. We develop a dynamical criterion based on the distribution function of stars in various Galactic components, using action integrals to identify halo members, and we compare this to the metallicity and to kinematically selected samples.Results.With this new method, we find 1156 stars in the solar neighbourhood that are likely members of the stellar halo. Our dynamically selected sample consists mainly of distant giants on elongated orbits. Their metallicity distribution is rather broad, with roughly half of the stars having [M/H] ≥ −1 dex. The use of different selection criteria has an important impact on the characteristics of the velocity distributions obtained. Nonetheless, for our dynamically selected and for the metallicity selected samples, we find the local velocity ellipsoid to be aligned in spherical coordinates in a Galactocentric reference frame. This suggests that the total gravitational potential is rather spherical in the region spanned by the orbits of the halo stars in these samples.
Applegate mechanism in post-common-envelope binaries: Investigating the role of rotation
Authors: Navarrete F. H. , Schleicher D. R. G. , Zamponi Fuentealba J. , Völschow M. 
Published: March 2018

Context. Eclipsing time variations are observed in many close binary systems. In particular, for several post-common-envelope binaries (PCEBs) that consist of a white dwarf and a main sequence star, the observed-minus-calculated (O–C) diagram suggests that real or apparent orbital period variations are driven by Jupiter-mass planets or as a result of magnetic activity, the so-called Applegate mechanism. The latter explains orbital period variations as a result of changes in the stellar quadrupole moment due to magnetic activity.
Aims. In this work we explore the feasibility of driving eclipsing time variations via the Applegate mechanism for a sample of PCEB systems, including a range of different rotation rates.
Methods. We used the MESA code to evolve 12 stars with different masses and rotation rates. We applied simple dynamo models to their radial profiles to investigate the scale at which the predicted activity cycle matches the observed modulation period, and quantifiy the uncertainty. We further calculated the required energies to drive the Applegate mechanism.
Results. We show that the Applegate mechanism is energetically feasible in 5 PCEB systems. In RX J2130.6+4710, it may be feasible as well considering the uncertainties. We note that these are the systems with the highest rotation rate compared to the critical rotation rate of the main-sequence star.
Conclusions. The results suggest that the ratio of physical to critical rotation rate in the main sequence star is an important indicator for the feasibility of Applegate’s mechanism, but exploring larger samples will be necessary to probe this hypothesis.
Immunonkologie beim Nierenzellkarzinom – Aktueller Stand
Authors: Grimm Marc-Oliver , Foller Susan 
Published: March 2018

ZusammenfassungDurch die Zulassung des Immun-Checkpoint-Inhibitors Nivolumab (Opdivo®) und neuer Multikinaseinhibitoren (Cabozantinib, Lenvatinib, Tivozanib) hat sich die systemische Therapie des metastasierten Nierenzellkarzinoms in den letzten 2 Jahren erheblich verändert. Nivolumab und Cabozantinib sollen als zweite Therapielinie nach Versagen einer VEGF basierten Therapie lt. S3-Leitlinie eingesetzt werden. In der zulassungsrelevanten Studie hatte sich für den Immun-Checkpoint-Inhibitor Nivolunab im Vergleich zu Everolimus ein besseres medianes Gesamtüberleben (26 Monate vs. 19,7 Monate; Hazard ratio 0,73; p = 0,0006), eine signifikant höhere Ansprechrate (26 % vs. 5 %) und ein günstigeres Nebenwirkungsprofil gezeigt. Aktuell werden zahlreiche Kombinationen mit PD-1/PD-L1-Inhibitoren in der Erstlinientherapie gegen Sunitinib getestet. Die randomisierte Phase-III-Studie CheckMate 214 zeigte als erste eine signifikant höhere objektive Ansprechrate (42 % vs. 27 %, p < 0,0001) sowie ein längeres Gesamtüberleben (Median für Nivo + Ipi bisher nicht erreicht (28,2 – NE) vs. 26,0 Monate; Hazard ratio 0,63) für die Kombination aus Nivolumab und dem CTLA-4 Antikörper Ipilimumab bei intermediate und high risk Patienten nach IMDC. CheckMate 214 zeigt darüber hinaus Vorteile für die Immuntherapie in Bezug auf Nebenwirkungen und Lebensqualität gegenüber Sunitinib. Allerdings zeigt sich eine deutliche Zunahme immunvermittelter Nebenwirkungen. Eine randomisierte Studie mit dem PD-L1-Inhibitor Atezolizumab kombiniert mit dem VEGF-Antikörper Bevacizumab ergab für PD-L1-positive Patienten ein signifikant längeres progressionsfreies Überleben gegenüber Sunitinib; dieser Vorteil fand sich in allen Risikogruppen. Weitere Phase-III-Studien mit neueren VEGFR-TKIs (Axitinib, Cabozantinib, Lenvatinib) und PD-1/PD-L1-Inhibitoren laufen aktuell. Zusammenfassend wird der PD-1-Immun-Checkpoint-Inhibitor Nivolumab eine Standardtherapie beim metastasierten Nierenzellkarzinom nach antiangiogenetischer Vortherapie bleiben. Die Kombination aus Nivolumab und Ipilimumab wird Standardtherapie bei Patienten mit intermediärem bzw. hohem Risiko in der Erstlinie. Für eine Bewertung der Kombinationen aus PD-1/PD-L1-Inhibitoren und Bevacizumab bzw. VEGFR-TKIs werden weitere Daten (Gesamtüberleben, Nebenwirkungsspektrum) benötigt.
Comprehensive, high-resolution binding energy landscapes reveal context dependencies of transcription factor binding
Authors: Le Daniel D. , Shimko Tyler C. , Aditham Arjun K. , Keys Allison M. , Longwell Scott A. , Orenstein Yaron , Fordyce Polly M. 
Published: March 2018

SignificanceTranscription factors (TFs) are key proteins that bind DNA targets to coordinate gene expression in cells. Understanding how TFs recognize their DNA targets is essential for predicting how variations in regulatory sequence disrupt transcription to cause disease. Here, we develop a high-throughput assay and analysis pipeline capable of measuring binding energies for over one million sequences with high resolution and apply it toward understanding how nucleotides flanking DNA targets affect binding energies for two model yeast TFs. Through systematic comparisons between models trained on these data, we establish that considering dinucleotide (DN) interactions is sufficient to accurately predict binding and further show that sites used by TFs in vivo are both energetically and mutationally distant from the highest affinity sequence.
TWEAK and RIPK1 mediate a second wave of cell death during AKI
Authors: Martin-Sanchez Diego , Fontecha-Barriuso Miguel , Carrasco Susana , Sanchez-Niño Maria Dolores , Mässenhausen Anne von , Linkermann Andreas , Cannata-Ortiz Pablo , Ruiz-Ortega Marta , Egido Jesus , Ortiz Alberto , Sanz Ana Belen 
Published: March 2018

Significance
Acute kidney injury (AKI) has a mortality of 50%. There is no satisfactory therapy and the incidence is increasing. The etiology of AKI is heterogeneous, and this has therapeutic implications. Here we show that necroptosis plays a role in a second wave of tubular cell death in experimental toxic AKI. This second wave of death is triggered by TWEAK activation of the Fn14 receptor and contributes to persistence of injury. We previously observed that the initial wave of cell death was ferroptosis dependent and necroptosis independent. The identification of a pathway contributing to AKI persistence may facilitate the design of therapies, as exemplified by the protection afforded by RIPK1 inhibitors when administered after AKI had been induced.
Comparison of measurement capability with 100 μmol/mol of carbon monoxide in nitrogen
Authors: Lee Jeongsoon , Lee JinBok , Lim Jeongsik , Tarhan l , Liu Hsin-Wang , Aggarwal Shankar G 
Published: March 2018

Carbon monoxide (CO) in nitrogen was one of the first types of gas mixtures used in an international key comparison. The comparison dates back to 1998 (CCQMK1a) [1]. Since then, many National Metrology Institutes (NMIs) have developed calibration and measurement capabilities (CMCs) for these mixtures. Recently, NMIs in the APMP region have actively participated in international comparisons to provide domestic services. At the 2013 APMP meeting, several NMIs requested a CO comparison to establish CO/N2 certification for industrial applications, which was to be coordinated by KRISS. Consequently, this comparison provides an opportunity for APMP regional NMIs to develop CO/N2 CMC claims.
The goal of this supplementary comparison is to support CMC claim for carbon monoxide in the N2 range of 50–2000 μmol/mol. An extended range may be supported as described in the GAWG strategy for comparisons and CMC claims.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Integrated Forehead and Temporal Augmentation Using 3D Printing-Assisted Methyl Methacrylate Implants
Authors: Hirohi Toshitsugu , Nagai Koji , Ng Donald , Harii Kiyonori 
Published: March 2018

Abstract

Background
Achieving aesthetic results with forehead augmentation procedures remains challenging. We have developed a method of integrated forehead and temporal augmentation using a three-dimensional (3D) printing-assisted methyl methacrylate implant.

Objectives
The study objective was to assess the importance of combined temporal augmentation when performing forehead augmentation.

Methods
We identified 34 patients (from 2000 to 2010) who underwent forehead augmentation with a methyl methacrylate implant contoured in situ during surgery and 41 patients (from 2010 to 2016) who underwent integrated forehead and temporal augmentation with a prefabricated methyl methacrylate implant. We conducted a retrospective chart review of patient data including operation time, complications, and instances of revision surgery. Two blinded plastic surgeons scored the aesthetic results of the operations on a 4-point scale (1, poor, to 4, excellent) based on preoperative and posttreatment photographs.

Results
The integrated augmentation method resulted in a lower frequency of posttreatment implant removal (one [2%] vs. six [18%]; P &lt; .05), a lower frequency of filler injection for touch up (one [2%] vs. six [18%]; P &lt; .05), and higher mean aesthetic scores (3.7 ± 0.5 vs. 2.2 ± 1.0; P &lt; . 001) compared to the forehead augmentation method. There was no statistically significant difference in surgical complications between the two groups.

Conclusions
Integrated forehead and temporal augmentation using a 3D printing-assisted methyl methacrylate implant may be the optimal available procedure, enabling the custom fabrication of contours requested by the patient and providing a rejuvenating and balancing effect on facial appearance.

Level of Evidence: 3
MetaboCraft: building a Minecraft plugin for metabolomics
Authors: Megalios Anargyros , Daly Rónán , Burgess Karl 
Published: March 2018

Abstract

Motivation
The rapid advances in metabolomics pose a significant challenge in presentation and interpretation of results. Development of new, engaging visual aids is crucial to advancing our understanding of new findings.

Results
We have developed MetaboCraft, a Minecraft plugin which creates immersive visualizations of metabolic networks and pathways in a 3D environment and allows the results of user experiments to be viewed in this context, presenting a novel approach to exploring the metabolome.

Availability and implementation
https://github.com/argymeg/MetaboCraft/; https://hub.docker.com/r/ronandaly/metabocraft/

Supplementary information
Supplementary data are available at Bioinformatics online.
scanPAV: a pipeline for extracting presence–absence variations in genome pairs
Authors: Giordano Francesca , Stammnitz Maximilian R , Murchison Elizabeth P , Ning Zemin 
Published: March 2018

Abstract

Motivation
The recent technological advances in genome sequencing techniques have resulted in an exponential increase in the number of sequenced human and non-human genomes. The ever increasing number of assemblies generated by novel de novo pipelines and strategies demands the development of new software to evaluate assembly quality and completeness. One way to determine the completeness of an assembly is by detecting its Presence–Absence variations (PAV) with respect to a reference, where PAVs between two assemblies are defined as the sequences present in one assembly but entirely missing in the other one. Beyond assembly error or technology bias, PAVs can also reveal real genome polymorphism, consequence of species or individual evolution, or horizontal transfer from viruses and bacteria.

Results
We present scanPAV, a pipeline for pairwise assembly comparison to identify and extract sequences present in one assembly but not the other. In this note, we use the GRCh38 reference assembly to assess the completeness of six human genome assemblies from various assembly strategies and sequencing technologies including Illumina short reads, 10× genomics linked-reads, PacBio and Oxford Nanopore long reads, and Bionano optical maps. We also discuss the PAV polymorphism of seven Tasmanian devil whole genome assemblies of normal animal tissues and devil facial tumour 1 (DFT1) and 2 (DFT2) samples, and the identification of bacterial sequences as contamination in some of the tumorous assemblies.

Availability and implementation
The pipeline is available under the MIT License at https://github.com/wtsi-hpag/scanPAV.

Supplementary information
Supplementary data are available at Bioinformatics online.
Two low-order nonconforming finite element methods for the Stokes flow in three dimensions
Authors: Hu Jun , Schedensack Mira 
Published: March 2018

Abstract
In this paper, we propose two low-order nonconforming finite element methods (FEMs) for the three-dimensional Stokes flow that generalize the nonconforming FEM of Kouhia & Stenberg (1995, A linear nonconforming finite element method for nearly incompressible elasticity and Stokes flow. Comput. Methods Appl. Mech. Eng, 124, 195–212). The finite element spaces proposed in this paper consist of two globally continuous components (one piecewise affine and one enriched component) and one component that is continuous at the midpoints of interior faces. We prove that the discrete Korn inequality and a discrete inf–sup condition hold uniformly in the mesh size and also for a nonempty Neumann boundary. Based on these two results, we show the well-posedness of the discrete problem. Two counterexamples prove that there is no direct generalization of the Kouhia–Stenberg FEM to three space dimensions: the finite element space with one nonconforming and two conforming piecewise affine components does not satisfy a discrete inf–sup condition with piecewise constant pressure approximations, while finite element functions with two nonconforming and one conforming component do not satisfy a discrete Korn inequality.
Dispersively formed quasi-periodic fast magnetosonic wavefronts due to the eruption of a nearby mini-filament
Authors: Shen Yuandeng , Song Tengfei , Liu Yu 
Published: March 2018

Abstract
Observational analysis is performed to study the excitation mechanism and propagation properties of a quasi-periodic fast-propagating (QFP) magnetosonic wave. The QFP wave was associated with the eruption of a nearby mini-filament and a small B4 Geostationary Operational Environmental Satellite (GOES) flare, which may indicate that the generation of a QFP wave does not require much flare energy. The propagation of the QFP wave was along a bundle of funnel-shaped open loops with a speed of about 1100 ± 78 km s−1 and an acceleration of −2.2 ± 1.1 km s−2. Periodicity analysis indicates that the periods of the QFP wave are 43 ± 6 and 79 ± 18 s. For the first time, we find that the periods of the QFP wave and the accompanying flare are inconsistent, which is different from the findings reported in previous studies. We propose that the present QFP wave was possibly caused by the mechanism of dispersive evolution of the initially broad-band disturbance resulting from the nearby mini-filament eruption.
On the evolutionary status and pulsations of the recently discovered blue large-amplitude pulsators (BLAPs)
Authors: Romero Alejandra D , Córsico A H , Althaus L G , Pelisoli I , Kepler S O 
Published: March 2018

Abstract
The blue large-amplitude pulsators (BLAPs) constitute a new class of pulsating stars. They are hot stars with effective temperatures of ∼30 000 K and surface gravities of log g ∼ 4.9, that pulsate with periods in the range 20−40 min. Until now, their origin and evolutionary state, as well as the nature of their pulsations, were not been unveiled. In this paper, we propose that the BLAPs are the hot counterpart of the already known pulsating pre-extremely low mass (pre-ELM) white dwarf (WD) stars, that are He-core low-mass stars resulting from interacting binary evolution. Using fully evolutionary sequences, we show that the BLAPs are well represented by pre-ELM WD models with high effective temperature and stellar masses ∼0.34 M⊙. From the analysis of their pulsational properties, we find that the observed variabilities can be explained by high-order non-radial g-mode pulsations or, in the case of the shortest periods, also by low-order radial modes, including the fundamental radial mode. The theoretical modes with periods in the observed range are unstable due to the κ mechanism associated with the Z-bump in the opacity at log T ∼ 5.25.