bluuebunny/crossref_metadata_2025_split huggingface dataset:
CXCL9: a biomarker for the coronary slow flow phenomenon in patients with coronary artery disease
Authors: Liang youfeng , Lin xianhe , Xu yuanyuan , Wang chunmiao , Zhou Qi 
Published: August 2019

Abstract
Background: Atherosclerosis is a chronic inflammatory disease. The pathology underlying the disease consists of accumulation of the extracellular matrix, lipid and inflammatory cells. Coronary Slow Flow Phenomenon (CSFP) is closely related to inflammatory responses, while chemokines play an important role in the progression of atherosclerosis. However, the relationship between chemokines and CSFP is unclear. In this study, our aims were to evaluate the association between CXC Chemokines 9 (CXCL9) levels and CSFP in patients with coronary artery disease.

Methods: We studied 46 patients diagnosed with CSFP and classed them as the CSFP group. 50 patients with normal coronary angiography (CAG) were randomly selected as the no-CSFP group in our study. The mean TIMI frame count was used to measure coronary blood flow velocity. The clinical and biochemical index, including serum levels of IL1, IL-6, IL-10, CXCL9, CD40L and interferon-γ (IFN-γ), were analyzed in all subjects.

Results: The serum levels of IL-1, IL-6, IL-10, CXCL9, CD40L, IFN-γ and CXCL9 in the CSFP group were significantly higher than those in the no-CSFP group, with the differences being statistically significant (p<0.001). Furthermore, Pearson's correlation analysis reflected a significant positive correlation (r=0.171, p=0.01) in CXCL9 levels. Multivariate logistic regression analysis showed that CXCL9 are important risk factors for CSFP (β=1.795, P=0.000). Subsequent ROC curve analyses indicated that the serum CXCL9 levels demonstrated a high diagnostic value in differentiating patients with CSFP from that of normal controls (Area Under the Curve = 0.758) and the serum CXCL9 level of 131.915 mg/L was a predictor of CSFP, with a sensitivity of 54.3% and a specificity of 96.0%.

Conclusions: Our findings are indicative of the potential clinical implications of CXCL9 in the occurrence and development of CSFP.
Using the Multiphase Optimization Strategy (MOST) Framework to Test Intervention Delivery Strategies: A Study Protocol
Authors: Broder-Fingert Sarabeth , Kuhn Jocelyn Lara , Sheldrick Radley Christopher , Chu Andrea , Fortuna Lisa , Jordan Megan , Rubin Dana , Feinberg Emily 
Published: August 2019

Abstract
Background Delivery of behavioral interventions is complex, as the majority of interventions consist of multiple components used either simultaneously, sequentially, or both. The importance of clearly delineating delivery strategies within these complex interventions - and furthermore understanding the impact of each strategy on effectiveness - has recently emerged as an important facet of intervention research. Yet, few methodologies exist to prospectively test the effectiveness of delivery strategies and how they impact implementation. In the current paper, we describe a study protocol for a large randomized controlled trial in which we will use the Multiphase Optimization Strategy (MOST) – a novel framework developed to optimize interventions - to test the effectiveness of intervention delivery strategies using a factorial design. We apply this framework to delivery of Family Navigation (FN), an evidence-based care management strategy designed to reduce disparities and improve access to behavioral health services, and test four components related to its implementation. Methods/Design The MOST framework contains three distinct phases: Preparation, Optimization, and Evaluation. The preparation phase for this study occurred previously. The current study consists of the optimization and evaluation phases. Children ages three-to-twelve years-old who are detected as “at-risk” for behavioral health disorders (n=304) at a large, urban federally qualified community health center will be referred to a Family Partner – a bi-cultural, bi-lingual member of the community with training in behavioral health and systems navigation – who will perform FN. Families will then be randomized to one of 16 possible combinations of FN delivery strategies (2x2x2x2 factorial design). The primary outcome measure will be achieving a family-centered goal related to behavioral health services within 90 days of randomization. Implementation data on fidelity, acceptability, feasibility, and cost of each strategy will also be collected. Results from the primary and secondary outcomes will be reviewed by our team of stakeholders to optimize FN delivery for implementation and dissemination based on effectiveness, efficiency, and cost. Discussion In this protocol paper, we describe how the MOST Framework can be used to improve intervention delivery. These methods will be useful for future studies testing intervention delivery strategies and their impact on implementation.
Whole-genome identification of chemosensory genes in two sister blister beetles provides insights into chemosensory evolution
Authors: Wu Yuanming , Liu Yang-Yang , Chen Xiang-Sheng 
Published: August 2019

Abstract
Background: Commonly known as blister beetles or Spanish fly, there are more than 1,500 species in the Meloidae family (Coleoptera:Tenebrionoidea) that produce the potent defensive blistering agent cantharidin, which has recently been exploited for cancer therapy. Hycleus cichorii and Hycleus phaleratus are exploited as traditional Chinese medicine over 2,000 years due to their ability to biosynthesize cantharidin. These blister beetles share highly similar environments and ecological niches. To understand the role of the chemosensory system in speciation and evolution in the beetles, we identified the chemosensory gene families in whole genome of both blister beetle comprehensively.
Results: We identified 29 OBPs, 10 CSPs, 116 ORs, 80 GRs, and 35 IRs in H. phaleratus and 30 OBPs, 10 CSPs, 191 ORs, 92 GRs and 42 IRs in H. cichorii. The 7 groups of beetles’ ORs were recovered, but a new pattern of ORs in Coleoptera were surfaced, due to lack of whole OR repertoire for comparison to T. castaneum before. The OR number is varied, identified in H. cichorii 64% more than that in H. phaleratus (191 VS 116), which maybe an evolution event between these blister beetle’s speciation. A major Hycleus-specific expansion clade of bitter GRs is evident based on our phylogenetic tree, in which, clustered more than 50% Hycleus-bitter GRs. All the ten clade of beetles’ antennal IR identified in both Hycleus beetles. Interestingly, IR75 and IR41a were obviously expensed compare to other insects.
Conclusions: The GR and IR expansion events may promote Hycleus genus evolution. Our data will provide a basis for future species protection and speciation focusing on the blister beetle.
Re-formation of absent anterior chamber by iris incision using a 20-gauge knife in eyes with advanced paediatric vitreoretinopathies
Authors: Chen Chunli , Tian Tian , Zhao Peiquan , Li Xiaorong 
Published: August 2019

Abstract
Background To present the novel usage of iris incision in paediatric patients lacking an anterior chamber due to various advanced vitreoretinopathies.Methods Forty-one patients (41 eyes) were enrolled in this consecutive, prospective study. Iris incision was performed in all patients. The number of iris incision times, surgical procedures, and intraoperative and postoperative complications were collected. Patients were followed up for at least 6 months.Results Anterior chamber formation was achieved with only 1 initial episode of iris incision in 28 (68.3%) eyes, with 2 episodes in 11 (26.8%) eyes, and with 3 episodes in the remaining 2 (4.9%) eyes, which also underwent 1 episode of external SRF drainage. Except for iris incarceration, which occurred in 7 (17%) of the eyes during surgery, no other related complications were noted at the last follow-up.Conclusions This novel use of iris incision is effective, simple and safe in the management of an lost anterior chamber.
Validation Of Cariogram In Caries Prediction At Woman And Their Children 4 Years After Pregnancy – Longitudinal Randomized Control Study
Authors: Dolic Olivera , Obradovic Marija , Kojic Zeljka , Trtic Natasa , Sukara Slava , Knezevic Natasa , Veselinovic Valentina 
Published: August 2019

Abstract
Aim To evaluate Cariogram caries risk assessment during pregnancy with DMFT/dmft incidence at mother and children 4-years later.Background To validate baseline caries risk classifications according to Cariogram for pregnant women with the actual DMFT development after 4-year and the second aim was to validate assessed caries risk at pregnant women according to Cariogram with caries development at their children four years after.Methods The study population consisted of 96 pregnant women (average age 27, 4 years at baseline) that completed clinical baseline examination and salivary tests. A caries risk assessment was made using Cariogram model and according to it, participants were divided into five risk groups. The follow-up study was initiated 4 years later and the 80 pairs of mother and children (from that pregnancy) were re-examined using the same procedure as did at baseline. An individual caries risk profile and DMFT/dmft incidence were made for each woman and child. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for two cut-off were calculated to express the outcome.Results There was a strong association between the risk categories of pregnant women and their offspring as well as between caries development in children and the Cariogram risk categories of their mother in pregnancy. Sensitivity and PPV for new DMFT (ΔDMFT > 0) over 4 years for women was high (>80%) for those participants assessed with 0-60% “chance to avoid caries“, as well as diagnostic accuracy (74.00%). High specificity (91.00%), very high PPV (95.00%) and clinically useful values according to Youden’s index (0.53) were obtained for moderate and two lowest risk groups for dmft in children.Conclusions With the limits of this study, Cariogram was valid and highly predictive in caries risk assessment in children based on caries risk assessment of their mother in pregnancy. The Cariogram model can be useful tool for caries prediction in both groups of woman and their children based on caries risk assessment during pregnancy.
Probiotics for preventing and treating gastro-oesophageal reflux/gastro-oesophageal reflux disease in infants: A systematic review and meta-analysis
Authors: Foster Jann , Dahlen Hannah , Fijan Sabina , Badawi Nadia , Schmied Viginia , Thornton Charlene , Smith Caroline , Psaila Kim 
Published: August 2019

Abstract
Background Gastro-oesophageal reflux (GOR) and Gastro-oesophageal reflux disease (GORD) are common during infancy and can cause substantial discomfort in infants, parental distress and financial burden on parents and the health care system. Effective treatment regimens, however, remain elusive. Probiotics given to women during pregnancy and lactation, and babies may have therapeutic effects when it comes to GOR/GORD. The objective of this systematic review and meta-analysis is to evaluate the efficacy of probiotic supplementation for the prevention and treatment of GOR/GORD in infants.Methods Literature searches were conducted using MEDLINE, EMBASE and the Cochrane Central Register of Controlled trials. Only randomised controlled trials (RCTs) were included. A meta-analysis of included trials was performed using the Cochrane Collaboration methodology where possible. Results Six RCTs examined the prevention or treatment with probiotics on GOR. There were no studies examining probiotics for GORD. A meta-analysis of 3 studies showed a statistically significant reduction in regurgitation episodes for the probiotic group compared to the placebo group [mean difference -1.44 episodes/day; 95% CI -1.71 to -1.17] but there was high heterogeneity (96%). Meta-analysis of two studies found a statistically significant increased number of stools per day in the probiotic group compared to the placebo group [mean difference 1.26, 95% CI 1.12 to 1.41]. However, there was moderate heterogeneity (69%). Individual studies reported: a decrease in crying time, increased gastric emptying rate, infant length and head circumference, visits to an emergency department or health professional, and loss of parent working days were significantly less with infants receiving probiotic compared to a placebo but more research is needed. Meta-analysis of two studies showed no difference in body weight between the two groups (minimal heterogeneity 23%). None of the studies reported any adverse effects for the women or infants. Conclusions Probiotic therapy appears promising with some evidence of benefit but most studies are small and there was high heterogeneity between the studies. The use of probiotics could potentially be a non-invasive, cost effective and preventative positive health strategy for both women and their babies. Further well controlled RCTs examining the effect of probiotics for GOR /GORD are warranted.
Risk factors and antihypertensive medications for mortality in elderly hospitalized hemodialysis patients: a multicenter retrospective study in China
Authors: SONG Yu-Huan , Cai Guang-Yan , Xiao Yue-Fei , Liu Jie-qiong , Liang Shuang , Chen Xiang-Mei 
Published: August 2019

Abstract
Background Elderly Hemodialysis patients are increasing yearly. Antihypertensive medications are commonly prescribed to hemodialysis patients but the optimal regimens to prevent morbidity andmortality are unknown. The goal of our study was to compare the association of routinely prescribed antihypertensive regimens with outcomes and analyze the risk factors in elderly hemodialysis patients.Methods This study was a retrospective cohort study based on data from adult hemodialysis patients (≥18 years old) admitted to 15 hospitals in China between 1 January 2009 and 31 December 2011. The characteristics of elderly hemodialysis patients (≥60 years old) were analyzed. Antihypertensive drugs into the following regimens: β-blockers, calcium channel blockers, renin–angiotensin system (RAS) blocking drugs and α-blockers. Logistic regression analysis was used to explore the risk factors for death adjusting for clinical and laboratory values and antihypertensive medications.Results A total of 7135 patients on maintenance hemodialysis including 2738 elderly patients were enrolled in this study. The mean levels of hemoglobin, albumin, blood calcium, phosphorus and parathyroid hormone (PTH) in elderly group were lower than the younger group. We compared the characteristics of 2492 survived elderly maintenance hemodialysis patients and 246 patients who died.Aging (OR = 1.59, 95% CI: 1.13-2.24), central venous catheter (OR = 1.62, 95% CI: 1.53-1.72) and Charlson comorbidities index>3(OR=1.97,95% CI: 1.49-2.60)were independently risk factors of mortality in elderly maintenance hemodialysis patients. High levels of hemoglobin (OR=0.76, 95%CI: 0.73-0.79), albumin (OR=0.87, 95%CI: 0.77-0.98), uric acid(OR=0.90,95%CI: 0.84-0.96)and those taking angiotensin-converting enzyme inhibitor (ACEI) or an angiotensin II receptor blocker (ARB) (OR=0.77, 95%CI: 0.58-0.90) had a lower risk of mortality.Conclusions Age, Charlson Comorbidities index >3, anemia and malnutrition, the use of central venous catheters and low serum uric acid level are risk factors for mortality in elderly maintenance hemodialysis patients. Taking ACEI/ARB can reduce the mortality of elderly maintenance hemodialysis patients.
An Inexpensive Way to Record and Quantify Bacterial Swarming
Authors: Chen Weijie , Tang Jay X. , Mani Sridhar 
Published: August 2019

Abstract
Bacterial swarming refers to a rapid spread, with coordinated motion, of flagellated bacteria on a semi-solid surface1. There has been extensive study on this particular mode of motility among microbiologists and biophysicists because of its interesting biological and physical properties (e.g. enhanced antibiotic resistance2, turbulent collective motion3). The existing equipment for recording swarm expansion rate can easily go beyond tens of thousands dollars4, yet the conditions are not accurately controlled, resulting in large variations across the assays. Here, we report a reliable protocol to perform reproducible bacterial swarming assays and an inexpensive way to record and quantify the swarming activity by time-lapse photography. This novel protocol consists of three main parts: 1) building a “homemade”, environment-controlled photographing incubator; 2) performing bacterial swarming assay; 3) taking serial photos over time and calculating the swarming rate. The homemade incubator is economical, easy to operate, and has wide applications. In fact, this system can be applied for any slow evolving biological process that needs to be monitored by camera under a controlled environment.
The Elite Deliberative Democratic Model in The Public Policy Formulation for Madrasah Diniyyah (Islamic Non Formal School) Development in East Java, Indonesia
Authors: Ismail Ismail , Wardi Moh 
Published: August 2019

<p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: normal;"><span class="tlid-translation"><span style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-ansi-language: EN;" lang="EN">This research intend to discuss about public policy from East Java province government to improve the quality of Islamic religious education. The results of this study were: (1) East Java Provincial Government used policy formulation model in the name "elite deliberative democratic ". A policy formulation model that combines several theories of policy formulation, there are elite, deliberative theory, and democratic theory. (2) The policy formulation was done through several stages: They are reading of the reality; preparation of the general policy of long-term development; arrangement of short-term development policy; the preparation and stipulation of Regional Regulations, and the Governor Regulation on Translation of APBD; (3). The government of East Java province has under graduate Scholarship program (S.1) for Madrasah diniyyah teachers.</span></span></p><p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: normal;"> </p><p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: normal;"><strong><span style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-ansi-language: IN;" lang="IN">Abstrak</span></strong></p><p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: normal;"><span class="tlid-translation"><span style="font-size: 10.0pt; font-family: 'Times New Roman',serif; mso-ascii-theme-font: major-bidi; mso-hansi-theme-font: major-bidi; mso-bidi-theme-font: major-bidi; mso-ansi-language: IN;" lang="IN">Penelitian ini bermaksud membahas tentang kebijakan publik dari pemerintah provinsi Jawa Timur untuk meningkatkan kualitas pendidikan agama Islam. Hasil penelitian ini adalah: (1) Pemerintah Provinsi Jawa Timur menggunakan model perumusan kebijakan dengan nama "elite deliberative demokratis". Sebuah model perumusan kebijakan yang menggabungkan beberapa teori perumusan kebijakan, ada elit, teori deliberatif, dan teori demokrasi. (2) Perumusan kebijakan dilakukan melalui beberapa tahap: Mereka membaca realitas; persiapan kebijakan umum pembangunan jangka panjang; pengaturan kebijakan pembangunan jangka pendek; persiapan dan penetapan Peraturan Daerah, dan Peraturan Gubernur tentang Penerjemahan APBD; (3) Pemerintah provinsi Jawa Timur memiliki program sarjana (S.1) untuk guru Madrasah diniyyah</span></span></p><p class="MsoNormal" style="margin-bottom: .0001pt; text-align: justify; line-height: normal;"> </p>
Efficient microalgae harvesting using a thermal flotation method with response surface methodology
Authors: Zou Xiaotong , Xu Kaiwei , Wen Hao , Xue Yating , Qu Yanhui , Li Yanpeng 
Published: August 2019

Abstract
Thermal pre-flocculation to enable dispersed air flotation is an economical and ecofriendly technology for harvesting microalgae from water. However, the underlying mechanism and optimal conditions for this method remain unclear. In this study, Chlorella vulgaris (C. vulgaris) and Scenedesmus obliquus (S. obliquus) were harvested using a thermal flotation process. The surface structure and characteristics (morphology, electricity, and hydrophobicity) of the microalgae were analyzed using FT-IR (Fourier transform infrared spectroscopy), SEM (scanning electron microscopy), zeta potential, and a hydrophobic test. Further, response surface methodology (RSM) was used to optimize the flotation process. The hydrophobicity of S. obliquus exceeded that of C. vulgaris; as such, under the thermal pre-flocculation, S. obliquus (88.16%) was harvested more efficiently than C. vulgaris (47.16%). Thermal pre-flocculation denatured the lipids, carbohydrate, and proteins of microalgal cell surfaces. This resulted in a decrease in the electrostatic repulsion between the cells and air bubbles. The highest harvesting efficiency was 91.96% at 70 °C, 1,412 rpm, and 13.36 min. The results of this study demonstrate the potential for economic and ecofriendly harvesting of microalgae for biofuels and other bioproducts industries.
Addressing the synergy determination in anaerobic co-digestion and the inoculum activity impact on BMP test
Authors: Donoso-Bravo Andres , Ortega Valentina , Lesty Yves , Bossche Hugues Vanden , Olivares Diego 
Published: August 2019

Abstract
Anaerobic mono-digestion and co-digestion are nowadays widely used in wastewater treatment plants (WWTP). However, the data processing of the conventional biochemical potential test (BMP) carried out to assess potential substrates should be enhanced to reduce the uncertainty of the results. In this study, two methodologies aiming to improve the data processing in anaerobic digestion studies were proposed. The methodologies aimed at the estimation of synergy in anaerobic co-digestion of organic waste and the standardization of the BMP test results by considering the activity of the inoculums under mono-digestion conditions. Both methodologies comprise the application of the Gompertz equation. For the first methodology, four cosubstrates and two types of substrates were used. Regarding synergy estimation, the cosubstrates dairy whey and grease sludge had an impact on the degradation kinetic. In regard to the second methodology, the results indicate that the activity of the inoculums exerts an influence on the BMP analysis, and it should be considered. This can be meaningful when comparing results among studies when different inoculums are used or even for studies where the same inoculum is used but it is taken at different reactor operational moments.