bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Validation of the Sample6 DETECTTM HT/L for AOAC Research Institute
Authors: Banerjee Kakolie , Pierson Brittney , Hu Chuxuan , Carrier Elijah , Malsick Lauren , Tarasova Yekaterina , Daudenarde Sophie , Brownell Daniel , Koeris Michael , Klass Nicole , Bird Patrick , Benzinger M Joseph , Agin James , Goins David 
Published: April 2018

Abstract
Background: Listeria spp. are an important foodborne human pathogen because of their ability to cause disease and high mortality in individuals, particularly pregnant women, neonates, the elderly, immunocompromised individuals, and children. The Sample6 DETECTTM HT/L Kit is a semi-automated qualitative pathogen detection system designed to detect Listeria spp. (L. monocytogenes, L. innocua, L. ivanovii, L. seeligeri, L. welshimeri, and L. marthii) in environmental samples using the Sample6 BioIlluminationTM technology. Objective: The study was done to evaluate the Sample6 DETECT HT/L Kit. The assay was evaluated for inclusivity, exclusivity, robustness, product consistency, and stability, and a matrix study of one environmental surface. Methods: The performance of the Sample6 DETECT HT/L was compared with U.S. Food and Drug Administration reference culture method for Listeria using an unpaired study design. Results: The Sample6 DETECT HT/L assay correctly identified all 50 inclusivity isolates and correctly excluded all 30 nontarget strains evaluated. The assay was not affected by minor variations in incubation temperature and time, or sample volume. Results across three production lots spanning the shelf life of the assay were consistent. In the matrix study, the Sample6 DETECT HT/L for Listeria correctly identified each test portion for the presence or absence of Listeria, and there were no statistically significant differences between candidate and reference method results. Conclusions: The data collected in this study demonstrate that the Sample6 DETECT HT/L assay is a reliable method for the detection of Listeria spp. on stainless-steel environmental surfaces after 22 h of enrichment.
Physical anthropology in 1918 and the founding of the U.S. journal
Authors: Little Michael A. 
Published: April 2018

AbstractIn 1918, the first issue of the American Journal of Physical Anthropology was prepared and distributed by Aleš Hrdlička, the Curator of Physical Anthropology at the Smithsonian Institution. This was a singular act, both in the general and specific sense. It was the first journal of physical anthropology published in the United States, and it was a sole effort by Hrdlička, who was committed to promoting and recognizing physical anthropology as a new science in America. On this 100th anniversary of the founding of the journal, Hrdlička's efforts were successful: physical/biological anthropology is a strong and timely discipline that represents a major area of scientific research today.
Hunter‐gatherer studies and human evolution: A very selective review
Authors: Hawkes Kristen , O'Connell James , Blurton Jones Nicholas 
Published: April 2018

AbstractThe century long publication of this journal overlapped major changes in the sciences it covers. We have been eyewitnesses to vast changes during the final third of the last century and beginning of this one, momentous enough to fundamentally alter our work separately and collectively. One (NBJ) from animal ethology, another from western North American archaeology (JOC), and a third (KH) from cultural anthropology came to longtime collaboration as evolutionary ecologists with shared focus on studying modern hunter‐gatherers to guide hypotheses about human evolution. Our findings have radically revised hypotheses each of us took for granted when we began. Our (provisional) conclusions are not the consensus among hunter‐gatherer specialists; but grateful that personal reflections are invited, we aim to explain how and why we continue to bet on them.
Theory of complex fluids in the warm dense matter regime and application to an unusual phase transition in liquid carbon
Authors: Dharma‐wardana M.W.C. 
Published: April 2018

Data from recent laser‐shock experiments or from simulations using density functional theory (DFT), molecular dynamics (MD), path integrals etc. that are available for warm dense carbon are compared with the corresponding results predicted using the neutral pseudo‐atom [NPA] method. The NPA results are in good agreement not only with the 3–12 g/cm3 regimes that have been studied via path‐integral Monte Carlo methods but even at low densities and low temperatures where transient covalent bonding dominates ionic correlations. Thus, the “prepeak” due to the C–C bond at ∼1.4 Å and other features found in the pair distribution function g[r] from DFT + MD simulations at 0.86 eV and 3.7 g/cm3 and other densities etc. are recovered accurately in the NPA + HNC (hypernetted‐chain) calculations. The exploration of regimes not covered by previous studies is presented together with evidence of an unusual phase transition of carbon in the liquid state to a vapour, as seen from the loss of ion–ion correlations. An abrupt decrease in the number of free electrons per ion occurs simultaneously. A metallic liquid with strong ionic correlations arising from transient C–C bonds becomes a metallic vapour. This occurs when carbon at the density of ∼1.0 g/cm3 and mean ionization Z = 4 transits abruptly to a disordered mono‐atomic vapour at 7 eV, with Z ≃ 3. The behaviour of the pressure, compressibility and the electrical conductivity as well as physical quantities available from X‐ray Thomson scattering are presented across the tentatively proposed phase transition.
Skating on thin ice: stimulant use and sub‐optimal adherence to HIV pre‐exposure prophylaxis
Authors: Hojilla J Carlo , Vlahov David , Glidden David V , Amico K Rivet , Mehrotra Megha , Hance Robert , Grant Robert M , Carrico Adam W 
Published: April 2018

AbstractIntroductionStimulant and heavy alcohol use are prevalent and associated with elevated risk for HIV seroconversion among men who have sex with men (MSM) and transgender women. In addition, each can pose difficulties for antiretroviral adherence among people living with HIV. Scant research has examined the associations of stimulant and heavy alcohol use with adherence to daily oral pre‐exposure prophylaxis (PrEP) among MSM and transgender women. To address this gap in the literature, we evaluated the hypothesis that stimulant use and binge drinking are prospectively associated with sub‐optimal PrEP adherence.MethodsWe analysed data from participants in a nested case‐cohort in the iPrEx open label extension. Stimulant use (i.e. powder cocaine, crack‐cocaine, cocaine paste, methamphetamine, cathinone) and binge drinking (i.e. ≥5 drinks in a single day) in the last 30 days were assessed. Baseline urine was tested for stimulants using immunoassays to reduce misclassification. Sub‐optimal adherence was defined as tenofovir drug concentrations in dried blood spots less than 700 fmol per punch, indicative of less than four doses per week. We tested the prospective association of stimulant use and binge drinking with sub‐optimal adherence at the 4‐week follow‐up visit.Results and DiscussionData from 330 participants were analysed. The majority of the participants were MSM (89%) with a median age at baseline of 29 years (interquartile range 24 to 39). Approximately 16% (52/330) used stimulants and 22% (72/330) reported binge drinking in the last 30 days. Stimulant users had fivefold greater odds of sub‐optimal PrEP adherence compared to non‐users in adjusted analysis (adjusted odds ratio [aOR] 5.04; [95% CI 1.35 to 18.78]). Self‐reported binge drinking was not significantly associated with sub‐optimal adherence after adjusting for stimulant use and baseline confounders (aOR 1.16 [0.49 to 2.73]). Depressive symptoms, being transgender, and number of sex partners were also not significantly associated with sub‐optimal PrEP adherence (p > 0.05).ConclusionsStimulant use is a risk factor for sub‐optimal PrEP adherence in the month following PrEP initiation. Comprehensive prevention approaches that reduce stimulant use may optimize PrEP adherence. Creating adherence plans that specifically address PrEP dosing in the context of ongoing stimulant use should also be considered.
Comparative Proteomics Analysis Reveals Trans Fatty Acid Isomers Activates Different Pathways in Human Umbilical Vein Endothelial Cell
Authors: Qiu Bin , Wang Qing , Du Fang‐Ling , Liu Li‐Na , Zong Ai‐Zhen , Jia Min , Liu Wei , Xu Tong‐Cheng 
Published: April 2018

AbstractTrans fatty acid (TFA), a group of unsaturated fats with at least one double bond in the trans configuration, plays a role in lipid metabolism, the structure of the cell membrane phospholipids, and apoptosis. Previous studies demonstrated that TFA was associated with coronary heart disease, obesity, and insulin resistance. Herein, a quantitative proteomics approach estimated the relative abundance of proteins in human umbilical vein endothelial cells treated with TFA (two different TFA structural isomers: 9t‐18:1 and 9t,12t‐18:2). The results revealed that 174 identified proteins were significantly altered with respect to expression. Furthermore, based on the cutoff values, 35 proteins were differentially expressed in the 9t‐18:1 group as compared to the control group, 69 proteins were differentially expressed in 9t,12t‐18:2 group as compared to the control group, and 120 proteins were differentially expressed in the 9t,12t‐18:2 group as compared to the 9t‐18:1 group. Based on the bioinformatics analysis, we found that TFA could alter the structural constitution of the cytoskeleton through protein interactions, localization into the cell membrane, and incorporation into the phospholipid of the cell. In addition, 17 differential apoptosis‐related proteins, including cell division cycle 42, superoxide dismutase 1, glyoxalase I, and macrophage migration inhibitory factor were also identified. Together, these results might emphasize the need for studying TFA‐induced biological processes.
Divergences in open quantum systems
Authors: Agón Cesar , Lawrence Albion 
Published: April 2018

AbstractWe show that for cubic scalar field theories in five and more spacetime dimensions, and for theT= 0 limit of the Caldeira-Leggett model, the quantum master equation for long-wavelength modes initially unentangled from short-distance modes, and at second order in perturbation theory, contains divergences in the non-Hamiltonian terms. These divergences ensure that the equations of motion for expectation values of composite operators closes on expectation values of renormalized operators. Along the way we show that initial “jolt” singularities which occur in the equations of motion for operators linear in the fundamental variables persist for quadratic operators, and are removed if one chooses an initial state projected onto low energies, following the Born-Oppenheimer approximation.
An Open-Label, Phase II Study of the Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (PIPF-002)
Authors: Gotfried Mark H. , Girod Carlos E. , Antin-Ozerkis Danielle , Burgess Tracy , Strombom Indiana , Stauffer John L. , Kirchgaessler Klaus-Uwe , Padilla Maria L. 
Published: April 2018

Abstract
Introduction
PIPF-002 was a phase 2, multicenter, open-label study of pirfenidone in patients with idiopathic pulmonary fibrosis (IPF) or other types of pulmonary fibrosis (PF). PIPF-002 terminated after pirfenidone became commercially available in the United States. The goal of PIPF-002 was to characterize the long-term safety of pirfenidone in these patients.

Methods
Between August 2003 and September 2006, 83 patients (IPF: 81, PF: 2) enrolled. Patients received pirfenidone in three divided doses daily, with the maintenance dose and schedule determined by enrollment group assignment. Treatment continued until patient withdrawal or study termination (2015). Treatment-emergent adverse events (TEAEs) were assessed by descriptive statistics.

Results
At baseline, median age was 70 years, mean percent predicted forced vital capacity was 67.7%, 33.7% of patients had cardiac disorders, 51.8% had gastroesophageal reflux disease, and 63.9% were receiving concomitant prednisone. Median pirfenidone dose and exposure duration were 2400 mg/day and 3.0 years, respectively. Cumulative total exposure was 279.7 patient-exposure years (PEY). Most patients (98.8%) reported ≥ 1 TEAE, with an overall incidence rate of 460.5 per 100 PEY. The most frequent TEAEs (incidence rate per 100 PEY) were nausea (23.6), IPF progression (16.1), fatigue (11.8), dyspnea (11.4), upper respiratory tract infection (11.4), and cough (10.7). Serious TEAEs were reported in 49 patients; the most frequent serious TEAEs were IPF progression and pneumonia. The most common reason for discontinuation was TEAEs (35 patients; 12.5 patients per 100 PEY), most frequently IPF progression and nausea. Overall, 21 patients died (7.5 per 100 PEY); 16 deaths were IPF-related.

Conclusions
Long-term safety and tolerability of pirfenidone findings in this study were consistent with the known safety profile of pirfenidone; no new safety signals were identified. These data support the continued use of pirfenidone in patients with IPF.

Funding
F. Hoffmann-La Roche Ltd./Genentech, Inc.

Trial Registration
ClinicalTrials.gov identifier, NCT00080223.

Plain Language Summary
Plain language summary available for this article.
Estimation of sea-ice thickness and volume in the Sea of Okhotsk based on ICESat data
Authors: Nihashi Sohey , Kurtz Nathan T. , Markus Thorsten , Ohshima Kay I. , Tateyama Kazutaka , Toyota Takenobu 
Published: April 2018

ABSTRACTSea-ice thickness in the Sea of Okhotsk is estimated for 2004–2008 from ICESat derived freeboard under the assumption of hydrostatic balance. Total ice thickness including snow depth (htot) averaged over 2004–2008 is 95 cm. The interannual variability of htot is large; from 77.5 cm (2008) to 110.4 cm (2005). The mode of htot varies from 50–60 cm (2007 and 2008) to 70–80 cm (2005). Ice thickness derived from ICESat data is validated from a comparison with that observed by Electromagnetic Induction Instrument (EM) aboard the icebreaker Soya near Hokkaido, Japan. Annual maps of htot reveal that the spatial distribution of htot is similar every year. Ice volume of 6.3 × 1011 m3 is estimated from the ICESat derived htot and AMSR-E derived ice concentration. A comparison with ice area demonstrates that the ice volume cannot always be represented by the area solely, despite the fact that the area has been used as a proxy of the volume in the Sea of Okhotsk. The ice volume roughly corresponds to that of annual ice production in the major coastal polynyas estimated based on heat budget calculations. This also supports the validity of the estimation of sea-ice thickness and volume using ICESat data.
The Active Energy Consumer in EU Law
Authors: CSERES KJ 
Published: April 2018

AbstractWith the availability of cheaper technology and the rise of digitalisation, consumers can actively participate in markets and also offer their own services or self-/co-produce products and services. Active consumers are fundamental building-blocks of the European Union’s goal to achieve smart, sustainable and inclusive growth in Europe. In the energy sector active consumers play a key role in promoting competition, ensuring affordable energy prices and security of supply, as well as contributing to the EU’s environmental and climate goals. By engaging in more efficient energy use, consumers are crucial actors to manage the energy transition. However, the present legal framework does not fully facilitate this active role. The aim of this article is to answer the question how EU law conceptualises and supports the active role of consumers in the regulation of energy markets.
Axial evolution of forced helical flame and flow disturbances
Authors: Smith Travis E. , Douglas Christopher M. , Emerson Benjamin L. , Lieuwen Timothy C. 
Published: April 2018

This paper presents 5 kHz stereo particle image velocimetry and OH planar laser induced fluorescence measurements of transversely forced swirl flames. The presence of transverse forcing on this naturally unstable flow both influences the natural instabilities, as well as amplifies disturbances that may not necessarily manifest themselves during natural oscillations. By manipulating the structure of the acoustic forcing field, both axisymmetric and helical modes are preferentially excited away from the frequency of natural instability. The paper presents a method for spatially interpolating the phase locked $r{-}z$ and $r{-}\unicode[STIX]{x1D703}$ planar velocity and flame position data, extracting the full three-dimensional structure of the helical disturbances. These helical disturbances are also decomposed into symmetric and anti-symmetric disturbances about the jet core, showing the subsequent axial evolution (in magnitude and phase) of each of these underlying disturbances. It is shown that out-of-phase acoustic forcing excites $m=\pm 1$ modes, but the flow field preferentially amplifies the counter-winding, co-rotating helical disturbance over the co-winding, counter-rotating helical disturbance. This causes the flow and flame to transition from a transverse flapping near the jet exit to a precessing motion further downstream. In contrast, in-phase forcing promotes axisymmetric $m=0$ disturbances which dominate the flow field over the entire axial domain. In both cases, the amplitudes of the anti-symmetric disturbances about the jet core grow with downstream distance before saturating and decaying, while the symmetric disturbances appear nearly negligible. It is suggested that this saturation and decay is due to linear effects (e.g. a negative spatial growth rate), rather than nonlinear interactions.
L1 + L2 to the power of culture: acculturation and language use for cognitive domains in bilinguals
Authors: HAMMER KATE 
Published: April 2018

abstractThis paper investigates the extent of second language (L2) use in four cognitive domains including mental calculation, planning (action plans), note-taking, and shopping lists. Participants include 149 highly educated L2-competent sequential Polish–English bilinguals who relocated to the UK1in early adulthood, and underwent processes of acculturation. The independent variables in this study include acculturation level, social network profile, predicted future domicile, and length of residence. The study employed both quantitative and qualitative approaches. Participants completed an online questionnaire and 14 were interviewed by the researcher. The study included the Complementarity Principle (CP) into the operationalisation and measurement of language use in bilinguals (Grosjean, 2010). The results show that acculturation level, social network profile, and predicted future domicile are strong predictors of the extent of L2 use in cognitive domains. Effects of context-specificity and language-dependence were also found, the latter specifically in the domain of mental calculation.
Growth, morphology and biological nitrogen fixation potential of perennial ryegrass-white clover swards throughout the grazing season
Authors: Guy C. , Hennessy D. , Gilliland T. J. , Coughlan F. , McCarthy B. 
Published: April 2018

AbstractSustainable ruminant production systems depend on the ability of livestock to utilize increased quantities of grazed herbage. The current study aimed to compare the effect of white clover (WC) inclusion and perennial ryegrass (PRG) ploidy on herbage dry matter (DM) production, plant morphology, nutritive value and biological nitrogen (N) fixation (BNF) under high N fertilizer use (250 kg N/ha) and high stocking rates (2.75 livestock units/ha). Four sward treatments (diploid-only, tetraploid-only, diploid-WC, tetraploid-WC) were evaluated over a full grazing season at a farmlet scale. White clover inclusion had a significant effect on herbage DM production, herbage growth rate, tiller density, organic matter digestibility, crude protein and BNF. Tetraploid swards had a lower tiller density, lower sward WC content and post-grazing sward height and increased organic matter digestibility and crude protein than diploid swards. White clover inclusion improved herbage DM production and nutritive value across a full grazing season, with tetraploid and diploid swards producing similar herbage DM yields across the year. Perennial ryegrass ploidy had an effect on WC morphology as plants in diploid-WC swards had narrower, longer stolons, fewer branches and more petioles than tetraploid-WC swards. The current study highlights the benefit of including WC in grass-based systems under a high N fertilizer regime and high stocking rate.
Modelling shoot growth and yield of Ceylon tea cultivar TRI-2025 (Camellia sinensis (L.) O. Kuntze)
Authors: Jayasinghe H. A. S. L. , Suriyagoda L. D. B. , Karunarathne A. S. , Wijeratna M. A. 
Published: April 2018

AbstractThe present study was aimed at stimulating the growth and yield of Sri Lankan tea cultivar TRI 2025 grown in different climatic regions in the country. The model was developed and calibrated using weather, crop and soil data collected from different climatic zones. The model is designed to simulate shoot replacement cycle, leaf area of a shoot, shoot growth, dry matter partitioning and tea shoot yield. The model was validated using shoot development and growth data not used for model calibration. These validation data were collected from low, mid and high elevations representing temperature and rainfall gradients in the country. Model calibration showed that thermal time required to initiate the fish leaf, 1st, 2nd and 3rd normal leaf in a tea shoot from the time of natural senescence of the scale leaves were 129, 188, 235, 296 °C days, respectively, and a tea shoot reached the harvestable stage after 393 °C days. The model simulated leaf area (cm2) and fresh weight (g/m2) of tea shoots at different developmental stages and locations which were in good agreement with the measured values at the validation stage (R2 > 0.92 and 0.98, respectively). Similarly, simulated shoot yields (g/m2/month) at the validation stage were strongly correlated with the measured values (n = 12, R2 > 0.58, RMSE = 5–17 g/m2/month). Thus, the model can be used to estimate the shoot yield of tea cultivar TRI 2025 grown in different climatic conditions in Sri Lanka. Areas requiring further improvements to the model are also discussed.
Performance and meat quality of broiler chicken fed a ration containing flaxseed meal and higher dietary lysine levels
Authors: Mir Nasir Akbar , Tyagi Praveen K. , Biswas Ashim Kumar , Tyagi Pramod K. , Mandal Asit B. , Wani Manzoor A. , Deo Chandra , Biswas Avishek , Verma Arun Kumar 
Published: April 2018

AbstractThe present study aimed to evaluate growth performance and meat quality of broiler chicken with respect to feeding of 100 g flaxseed meal (FM)/kg and increasing lysine levels in the broiler diet. The results revealed no effect of lysine and FM feeding on growth performance except for a negative effect of FM on feed efficiency of birds, which was countered by feeding 1.25 BIS lysine. Feeding FM improved the fatty acid profile of broiler chicken meat significantly, whereas no effect was observed for increasing lysine levels beyond BIS recommendation. FM significantly reduced meat cholesterol, fat, water-holding capacity (WHC), extract release volume (ERV) and antioxidant potential, whereas it increased the pH of fresh meat, drip loss and lipid peroxidation of broiler chicken meat. As compared with other lysine levels, generally 1.25 BIS lysine significantly increased the pH of refrigerated stored meat, WHC, ERV and antioxidant potential, whereas it significantly reduced cholesterol, fat, drip loss and lipid peroxidation of broiler chicken meat. Thus, the inclusion of 100 g FM/kg diet along with 1.25 BIS lysine in broiler ration was optimum for desirable broiler performance, fatty acid profile, oxidative stability and other functional properties of broiler chicken meat.