bluuebunny/crossref_metadata_2025_split huggingface dataset:
The decommissioning of oil and gas fields: Egyptian law and policy
Authors: Elshazly Mostafa 
Published: April 2019

Abstract
Legal issues around the decommissioning of oil and gas fields have generally been given insufficient attention by energy lawyers in most jurisdictions worldwide. Oil and gas lawyers, and other stakeholders in Egypt, face the same challenge. This article discusses the topic of the decommissioning of oil and gas fields in the context of the legal aspects and the regulatory framework for decommissioning in Egypt, demonstrating the main challenges relating to the legal framework for decommissioning arrangements in the country. At the heart of the legal challenges associated with the decommissioning of oil and gas fields in Egypt lies the most important question: who should pay the associated costs, and when? This article also presents some recommendations to enhance the current regulatory framework for the decommissioning of oil and gas fields in Egypt, to maintain the balance of interests between international oil companies and national oil companies active in Egypt.
The association between BMI and BSA–temozolomide-induced myelosuppression toxicities: a correlative analysis of NRG oncology RTOG 0525
Authors: Robins H Ian , Eickhoff Jens , Gilbert Mark R , Armstrong Terri S , Shi Wenyin , De Groot John F , Schultz Christopher J , Hunter Grant K , Valeinis Egils , Roach Mack , Youssef Emad F , Souhami Luis , Howard Steve P , Lieberman Frank S , Herman James G , Zhang Peixin , Mehta Minesh P 
Published: April 2019

Abstract

Background
Fearing increased myelotoxicity, many practitioners adjust the body surface area (BSA)-calculated doses in obese patients. Regarding temozolomide (TMZ), a prior study suggested men with a BSA &gt;2 m2 may experience increased toxicity; however, surprisingly, the inverse observation was noted in women, ie, BSA &lt;2 m2 was associated with higher toxicity. To further clarify this issue, data derived from a large clinical trial were analyzed.

Methods
The incidence of grade 3 and 4 myelotoxicity in a newly diagnosed glioblastoma phase 3 trial (RTOG 0525) was statistically correlated with BMI and separately with BSA. All patients received radiation and TMZ followed by adjuvant standard dose TMZ vs dose-dense TMZ; dosing regimen-associated myelotoxicity and BMI/BSA were analyzed separately. Obesity was defined as a BMI ≥30.

Results
There was no statistically significant correlation between gender and BSA and the occurrence of myotoxicities. For the standard arm, surprisingly the incidence of grade 3/4 myotoxicities in patients with a BMI &lt;30 was significantly higher than in patients with a BMI ≥30 (12% vs 1%, odds ratio [OR] 12.5, P &lt; .001). There was no significant difference between obese and nonobese patients (BMI “cut-point” of 30) in the dose-dense arm (OR = 0.9, 95% confidence interval: 0.4–1.6). The grade hematological 3/4 toxicity rate was significantly higher in women vs men (14% vs 8%) P = .009 in spite of the lack of association between gender and BSA or BMI.

Conclusion
TMZ dosing based on actual BSA is recommended with the caveat that woman are likely at higher toxicity risk.
Universal bound on sampling bosons in linear optics and its computational implications
Authors: Yung Man-Hong , Gao Xun , Huh Joonsuk 
Published: April 2019

ABSTRACT
In linear optics, photons are scattered in a network through passive optical elements including beam splitters and phase shifters, leading to many intriguing applications in physics, such as Mach–Zehnder interferometry, the Hong–Ou–Mandel effect, and tests of fundamental quantum mechanics. Here we present the fundamental limit in the transition amplitudes of bosons, applicable to all physical linear optical networks. Apart from boson sampling, this transition bound results in many other interesting applications, including behaviors of Bose–Einstein condensates (BEC) in optical networks, counterparts of Hong–Ou–Mandel effects for multiple photons, and approximating permanents of matrices. In addition, this general bound implies the existence of a polynomial-time randomized algorithm for estimating the transition amplitudes of bosons, which represents a solution to an open problem raised by Aaronson and Hance (Quantum Inf Comput 2012; 14: 541–59). Consequently, this bound implies that computational decision problems encoded in linear optics, prepared and detected in the Fock basis, can be solved efficiently by classical computers within additive errors. Furthermore, our result also leads to a classical sampling algorithm that can be applied to calculate the many-body wave functions and the S-matrix of bosonic particles.
Comparing fatal occupational accidents in Denmark and Sweden 1993–2012
Authors: Hansen C D 
Published: April 2019

Abstract

Background
Denmark and Sweden are in many respects two very similar countries with similar welfare state systems and work environment authorities. Nevertheless, marked differences in the incidence of fatal occupational accidents have been found in earlier comparisons of the two countries.

Aims
To investigate differences in the incidence of fatal occupational accidents in the period from 1993 to 2012 to establish to what extent characteristics of the deceased can explain some of the difference between the two countries.

Methods
Analyses of the accident registers of the two countries’ national work environment authorities with supplemental linkages to official registers on employment status are used to determine the incidence of fatal occupational accidents for different groups. The analysis is based on 2375 accidents (1068 in Denmark and 1307 in Sweden) over the period of 20 years. Poisson regression is used to derive incidence rates over time for specific groups.

Results
In the study period, the incidence of fatal occupational accidents decreased in both countries (incidence rate ratio [IRR]: 0.95), although the incidence was on average higher in Denmark (IRR: 1.20) and grew larger over time. This difference did not disappear after adjusting for age, sex and industry among the deceased (IRR: 1.12).

Conclusions
The incidence of fatal occupational accidents was slightly higher in Denmark in the entire period. The difference could not be explained completely by sociodemographic differences or differences related to the labour market structure in the two countries, i.e. other factors (e.g. cultural) may play a role in producing the difference.
Efficacy and safety of switching from rituximab to biosimilar CT-P10 in rheumatoid arthritis: 72-week data from a randomized Phase 3 trial
Authors: Shim Seung Cheol , Božić-Majstorović Ljubinka , Berrocal Kasay Alfredo , El-Khouri Elias Chalouhi , Irazoque-Palazuelos Fedra , Cons Molina Francisco Fidencio , Medina-Rodriguez Francisco G , Miranda Pedro , Shesternya Pavel , Chavez-Corrales Jose , Wiland Piotr , Jeka Slawomir , Garmish Olena , Hrycaj Pawel , Fomina Natalia , Park Won , Suh Chang-Hee , Lee Sang Joon , Lee Sung Young , Bae Yun Ju , Yoo Dae Hyun 
Published: April 2019

Abstract

Objective
To evaluate the efficacy and safety of CT-P10, a rituximab biosimilar after a single switch, during a multinational, randomized, double-blind Phase 3 trial involving patients with RA.

Methods
Patients received 48 weeks’ treatment with CT-P10 or United States- or European Union-sourced reference rituximab (US-RTX and EU-RTX, respectively). Patients entering the extension period (weeks 48–72) remained on CT-P10 (CT-P10/CT-P10; n = 122) or US-RTX (US-RTX/US-RTX; n = 64), or switched to CT-P10 from US-RTX (US-RTX/CT-P10; n = 62) or EU-RTX (EU-RTX/CT-P10; n = 47) for an additional course. Efficacy endpoints included Disease Activity Score using 28 joints (DAS28), American College of Rheumatology (ACR) response rates, and quality of life-related parameters. Pharmacodynamics, immunogenicity and safety were also assessed.

Results
At week 72, similar improvements were observed by disease activity parameters including DAS28 and ACR response rate in the four extension period treatment groups. Quality of life improvements at week 72 vs baseline were similarly shown during the extension period in all groups. Newly developed anti-drug antibodies were detected in two patients following study drug infusion in the extension period. Similar pharmacodynamic and safety profiles were observed across groups.

Conclusion
Long-term use of CT-P10 up to 72 weeks was effective and well tolerated. Furthermore, switching from reference rituximab to CT-P10 in RA was well tolerated and did not result in any clinically meaningful differences in terms of efficacy, pharmacodynamics, immunogenicity and safety.

Trail registration
ClinicalTrials.gov, http://clinicaltrials.gov, NCT02149121.
Sirt1 ameliorates monosodium urate crystal–induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway
Authors: Liu Lei , Zhu Xiaoxia , Zhao Tianyi , Yu Yiyun , Xue Yu , Zou Hejian 
Published: April 2019

Abstract

Objectives
Acute gout is an inflammatory response to MSU crystals. In our previous research, Sirt1 was shown to have an effect in preventing acute gouty inflammation. In the current study, we aimed to investigate the underlying mechanism involving Sirt1 in acute gout.

Methods
The cytological changes and Sirt1 expression in the synovium were observed in patients with acute or intermittent gout. The effect of Sirt1 and its mechanism in gout were studied in macrophages, C57BL/6 mice and Sirt1+/− mice.

Results
Sirt1 expression was increased in the peripheral blood mononuclear cells (PBMCs) of patients with acute gout but not in the chronic tophus tissue. The arthritis score and numbers of inflammatory cells in injured paw tissue from murine gout models were upregulated in Sirt1+/− mice compared with wild-type mice. A PCR array of the paw tissue from murine gout models indicated that Sirt1 activation might attenuate MSU-induced inflammation by altering the polarization state of macrophages. Furthermore, in patients with acute gout, the phagocytosis of MSU crystals by a macrophage was found in a smear of the joint fluid and large amounts of macrophages were also found in the synovium. The activation of Sirt1 in gouty mice actually decreased the tendency toward M1 polarization. The inhibition of PI3K/Akt partially blocked the anti-inflammatory effect of Sirt1 and the translocation of STAT6, and phosphorylated STAT6 expression was decreased in RAW 264.7 cells treated with MSU crystals.

Conclusion
Our studies revealed that Sirt1 ameliorates MSU-induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway.
Two populations of circulating PD-1hiCD4 T cells with distinct B cell helping capacity are elevated in early rheumatoid arthritis
Authors: Fortea-Gordo Paula , Nuño Laura , Villalba Alejandro , Peiteado Diana , Monjo Irene , Sánchez-Mateos Paloma , Puig-Kröger Amaya , Balsa Alejandro , Miranda-Carús María-Eugenia 
Published: April 2019

AbstractObjectiveA novel population of B helper cells, phenotypically CD4+CXCR5−PD-1hi, has been described in the synovial tissues and peripheral blood of seropositive RA patients, and termed ‘peripheral helper T’ (Tph) cells. Contrary to CD4+CXCR5+PD-1hi follicular helper T (Tfh), Tph cells are not located in lymphoid organs but accumulate in inflamed tissues. Our objective was to study the frequency of circulating Tph (cTph) and circulating Tfh cell counterparts (cTfh) in patients with early RA (eRA).MethodsFreshly isolated peripheral blood mononuclear cells from 56 DMARD-naïve eRA patients and 56 healthy controls were examined by flow cytometry. Autologous cocultures of naïve or memory B cells were established with isolated peripheral blood Tph or Tfh cells.ResultsSeropositive (RF+ and/or ACPA+, n = 38) but not seronegative eRA patients (n = 18) demonstrated increased frequencies and absolute numbers of cTph and cTfh cells. cTph but not cTfh cells expressed CCR2. Those eRA patients who experienced a significant clinical improvement at 12 months demonstrated a marked decrease of their cTph cell numbers whereas their cTfh cell numbers remained unchanged. Both isolated Tph and isolated Tfh cells were able to induce maturation of memory B cells, whereas only Tfh cells could differentiate naïve B cells.ConclusionTwo populations of PD-1hiCD4 T cells with distinct phenotype and B cell helping capacity are increased in the peripheral blood of seropositive eRA patients. Whereas cTph cells are present only in patients with an active disease, cTfh cells seem to be constitutively elevated.
REDUCTION OF STAFF RADIATION DOSE IN PROSTATIC ARTERY EMBOLISATION
Authors: Andrade G , Garzón W J , Khoury H J , Savignon J , de Barros V S M , Fernandes J L , Abud D G 
Published: April 2019

Abstract
Prostatic artery embolisation (PAE) is used to treat patients with benign prostatic hyperplasia and with lower urinary obstructive tract symptoms. It is an interventional procedure which uses fluoroscopy equipment and can result in exposure to high doses of radiation in patients and staff. We aimed to demonstrate the reduction of radiation doses received by staff during PAE by implementing an optimised protocol called Radiation Exposure Curtailment for Embolisation (RECiFE). This protocol was implemented in cooperation with the medical team and technical team using Siemens Combined Applications to Reduce Exposure (CARE) protocol. The results showed approximately 83% reduction in the radiation doses received by the main physician during PAE. Thus, by adjusting the acquisition parameters of the angiographic equipment and implementing the RECiFE protocol, it is possible to optimise the PAE procedure and reduce the staff radiation dose.
Societal Costs of Schizophrenia in Denmark: A Nationwide Matched Controlled Study of Patients and Spouses Before and After Initial Diagnosis
Authors: Hastrup Lene Halling , Simonsen Erik , Ibsen Rikke , Kjellberg Jacob , Jennum Poul 
Published: April 2019

AbstractBackgroundInformation on welfare cost of patients with schizophrenia and spouses is limited.AimThe main aim of this study to investigate factual societal mean annual costs per individual during 5 years before and after the initial diagnosis of schizophrenia.MethodA register-based cohort study of 12 227 patients with incident schizophrenia (International Classification of Diseases, Tenth Revision F20-F20.99) with spouses and 48 907 matched controls in Denmark during 2002–2016.ResultsThe total annual costs of health care and lost productivity were Euro 43 561 higher for patients with schizophrenia and health care costs and costs of lost productivity were increased during 5 years before the initial diagnosis. The total annual direct health care and indirect costs of lost productivity were Euro 21 888 higher for spouses to patients with schizophrenia than spouses of individuals with no diagnosis of schizophrenia. Also before initial diagnosis, health care costs and lost productivity were increased among spouses of patients with schizophrenia.ConclusionPatients with schizophrenia differed from the general population with respect to all included costs. The study documented a significant burden on spouses. The excess health care costs of schizophrenia are further increased by psychiatric and somatic comorbidity, and the societal costs are 4–10 times higher than chronic neurological disorders such as epilepsy and multiple sclerosis. Early onset of schizophrenia implies that patients are affected before finishing school and before entrance to labor market. Cost savings could be achieved by investments in preventive interventions reaching young people’s needs; in initiatives to reduce hospital admissions caused by medication side effects, substance misuse, and lifestyle factors; and in occupational training.
Incumbents’ response to demand-side policies: The case of solar and wind power sectors
Authors: Choi Hyundo 
Published: April 2019

AbstractThis work examines incumbents’ responses to two demand-side policies by focusing on their investment in new sustainable technologies. It focuses on how economic incentive and regulatory policies shape the market environment and this affects incumbents’ investment in new technologies. By using mediation and difference-in-difference regression models, it examines incumbent utilities’ investment in solar and wind power plants. It reveals that incumbent utilities under the economic incentive policy more invest in the solar and wind power than those under the regulatory policy, as it places stronger competitive pressure on incumbent utilities to adapt to the new technology. Further, incumbents prefer alternative technologies complementary to their existing competences and expand their investment in a global market under policy-induced competitive pressures.
Law-Making by and for the People: A Case for Pre-legislative Processes in India
Authors: Jain Dipika 
Published: April 2019

Abstract
Recent legislative trends in India reflect the need for a mandatory pre-legislative process. Pre-legislative consultation affords the benefit of legitimacy to laws arrived at through citizen participation. Furthermore, it informs decision-makers of the lived experiences of those most likely impacted by the legislation. Laws that receive pre-legislative consultation are attuned to realities, which increases the likelihood of their effectiveness. This article explores how several of India’s recent laws that received pre-legislative consultation have been rendered more robust and effective than others. As exemplified by current protests by transgender, intersex and gender non-conforming people in India, the Government’s most recent Transgender Bill, which neglected pre-legislative deliberation process, fails the people it purports to protect. As explored in this article, the Bill fails to uphold constitutionally protected principles, as recognized in the recent Supreme Court case that upheld transgender persons’ fundamental rights. As such, the Transgender Bill reflects a need to engage with the intrinsic and instrumental value of pre-legislative consultation and deliberation in India. In locating transnational trends towards employing such a process, this article argues that India would greatly benefit from mandatory pre-legislative consultation and deliberation. By creating a process that allows for citizen participation in law-making, particularly when such laws impact marginalized communities, legislation would reflect societal needs and eschew a top-down, majoritarian approach.
Code of the Tweet: Urban Gang Violence in the Social Media Age
Authors: Stuart Forrest 
Published: April 2019

AbstractAcademics, criminal justice professionals, and news outlets have warned that gang-associated youth use social media to taunt rivals and trade insults in ways that cause offline retaliation. But there is surprisingly little empirical research investigating how gang-associated youth deploy social media in gang conflicts. Criminal justice professionals routinely overstate the violent effects of social media challenges, which further exacerbates criminalization, racial stereotyping, and social inequality. Drawing from two years of ethnographic fieldwork on Chicago’s South Side, this study asks how gang-associated black youth use social media to challenge rivals. Bridging traditional theories of urban violence with emerging media scholarship, I argue that social media disrupt the key impression management practices associated with the “code of the street.” Specifically, gang-associated youth exploit social media to publicly invalidate the authenticity of their rivals’ performances of toughness, strength, and street masculinity. Challengers do so through “cross referencing,” “calling bluffs,” and “catching lacking.” Each strategy differs in its likelihood to catalyze physical retaliation, which is a function of the amount and depth of counter-evidence necessary to refute a given challenge. These findings carry important implications for addressing urban violence, gangs, and inequality in the social media age.
Efficacy of mineral supplementation to growing cattle grazing winter-wheat pasture in northwestern Oklahoma1
Authors: Gunter S A , Combs G F 
Published: April 2019

ABSTRACT
Two experiments were conducted to evaluate the efficacy of mineral supplementation to cattle grazing winter-wheat pasture. In experiment 1 (fall), 120 steers and heifers (body weight [BW] = 232 ± 11.4 kg) were assigned randomly to four blocks of replicated pastures during the second week of November in 2008 and 2009 and all herds (6 animals/pasture; 4.9 ha/pasture) were allowed to graze for 84 d. In experiment 2 (spring), 216 steers (BW = 248 ± 7.9 kg) were assigned randomly to five blocks of replicated pastures during the second week of February in 2009 and 2010 and all herds (12 or 6 animals/pasture; 4.9 ha/pasture) were allowed to graze for 84 d. Half the pastures in both experiments received a free-choice mineral mixture (Wheat Pasture Pro; Land O’Lakes Purina Feed, LLC; St. Paul, MN; Ca, 16% and P, 4%); mineral feeders were weighed weekly to determine mineral intake. All pastures were planted in early September of each year (67 kg of seed/ha) and fertilized with 50 kg of urea-N/ha. Standing herbage dry matter was determined midway between weigh dates by clipping wheat forage to the ground along 122 cm of drill rows at 10 locations/pasture. Data were analyzed by ANOVA, with treatment as the fixed effect and pasture, animal sex (experiment 1), and block as random effects. In experiment 1, cattle offered minerals had a 43% faster average daily gain (ADG; P = 0.02, 0.73 kg) than cattle not offered minerals (0.51 kg); hence, supplemented cattle weighed 6% more (P = 0.04; 286 kg) after 84 d than nonsupplemented cattle (271 kg). In experiment 2, cattle offered the mineral supplement had a faster ADG (20% increase; P = 0.04; 1.00 kg) than cattle not offered minerals (0.83 kg). Further, supplemented cattle weighed 4% more (P = 0.03; 326 kg) after 84 d than nonsupplemented cattle (312 kg). In both experiments, daily standing herbage dry matter averaged 1,381 kg/animal and never differed (P ≥ 0.47) between treatments. Mineral intakes averaged 135 (experiment 1) and 124 (experiment 2) g/d, resulting in a cost of supplement to kilogram of added BW gain of $0.53 and $0.64, respectively (assuming a mineral cost of $0.88/kg). Overall, supplementing an appropriate mineral mixture to cattle grazing winter-wheat pasture increased ADG in a cost-effective manner.
Molecular phylogeny reveals the gradual evolutionary transition to soft-bodiedness in click-beetles and identifies sub-Saharan Africa as a cradle of diversity for Drilini (Coleoptera: Elateridae)
Authors: Kundrata Robin , Bocak Ladislav 
Published: April 2019

AbstractDrilini are soft-bodied predatory click-beetles (Elateridae: Agrypninae) with incompletely metamorphosed females. Due to divergent morphology, their classification has been contentious. We present the first densely sampled molecular phylogeny of Drilini based on nuclear and mitochondrial markers. Altogether, 44 species, representing all genera, were analysed using maximum likelihood and the Bayesian approach. Molecular analyses recovered five major clades that were also well supported by morphology. Afrotropical lineages mark deep splits. Most Palearctic species belong to a terminal clade. A few species of the predominantly Afrotropical Selasia are distributed from Arabia up to the Himalayas and Thailand. The origin of Drilini is dated to the Late Eocene (~35.5 Mya) and rapid radiation is identified from the Eocene/Oligocene to the Middle Miocene. We describe the gradual transformation of male morphological traits, e.g. the level of sclerotization, structure of mouthparts, loss of the thoracic interlocking mechanism, shortened elytra and expanded larviform abdomen. Five new genera, Austroselasia, Habeshaselasia, Illubaboria, Malacodrilus and Mashaselasia are proposed. Latoselasia, previously a subgenus of Wittmerselasia, is elevated to the genus rank. Five new species, Habeshaselasia nekemtensis, H. illubaborensis, Illubaboria bicolor, Malacodrilus hajeki and Mashaselasia aethiopica are described.