bluuebunny/crossref_metadata_2025_split huggingface dataset:
Offshoot Decline and Bud Rot of Date Palm Caused by Three Species of Enterobacteriaceae
Authors: Abedinzadeh Alma , Falahi Charkhabi Nargues , Aeini Milad , Fazliarab Amal 
Published: November 2024

ABSTRACTDate palm (Phoenix dactylifera) considered a main income and food source for local individuals in producing countries. However, palm offshoot decline and bud rot disease was observed in some palm groves in Khuzestan province as a major date producer in Iran. Thirty‐five samples with rot and decline were collected from diseased offshoot from palm groves of six cities of Khuzestan during 2019–2021. Yellowing in outer leaves, black, brown or reddish brown spots were observed on petioles at the early stage, which gradually continues to rot. Seventy‐nine were isolated from symptomatic samples among which 38 strains caused rotting in the inoculated site and emission of a foul odour 3 weeks after inoculation on petioles and rachises of young offshoots. Based on the phenotypic characters, pathogenic strains categorised in three groups including Klebsiella oxytoca with 15, Kosakonia radicincitans with 12 and Citrobacter koseri with 11 strains. The phylogenic tree based on analysis of the concatenated partial sequences of two housekeeping genes, gyrB and infB, revealed that six representative strains clustered with the type strains of K. oxytoca and K. radicincitans. Furthermore, two strains were clustered with the type strain of C. koseri based on concatenated partial sequences of gyrB, fusA and pyrG genes. This is the first report of K. oxytoca, K. radicincitans and C. koseri, as agents of date palm offshoot decline and bud rot. The inundation of palm groves due to massive flood during 2019 and 2020 in Khuzestan province may intensify the outbreak of decline and offshoot rot disease.
Psychological Flexibility in Individuals With Substance Use Disorder: The Mediating Effect of Distress Tolerance and Stress
Authors: Yıldız Erman , Büyükfırat Emine 
Published: November 2024

ABSTRACTIntroductionPsychological flexibility is posited to aid individuals with substance use disorder (SUD) in managing stress and tolerating distress. However, the intricacies of this mechanism remain obscure.AimThis study investigates the potential mediating role of psychological flexibility in the relationship between distress tolerance and perceived stress among individuals with SUD.MethodThis cross‐sectional study evaluated 187 individuals with SUD, selected through non‐probability convenience sampling, using the Introductory Information Form, the Perceived Stress Scale, the Distress Tolerance Scale and the Acceptance and Action Questionnaire—Substance Abuse. Data analysis was conducted using SPSS 25 and further refined with Jamovi 2.4.14, employing advanced mediation analysis techniques.ResultsSignificant relationships were found between distress tolerance, perceived stress and psychological flexibility. Mediation model analysis showed that psychological flexibility mediated the relationship between distress tolerance and perceived stress.DiscussionThis study revealed that higher distress tolerance, higher psychological flexibility and lower perceived stress were associated. As individuals adopt a more flexible and accepting attitude towards distressing situations, they perceive stressful events as less threatening and more manageable.Implications for PracticeThe study suggests the need for psychiatric and mental health nursing practice and education to incorporate strategies to increase psychological flexibility.
Lay narratives of nationhood: Time, place and emotion in the talk of populist radical right‐wing supporters in Finland
Authors: Sakki Inari , Jaakkola Jenni , Hakoköngäs Eemeli , Martikainen Jari , Rovamo Helena 
Published: November 2024

AbstractInspired by previous research showing how populist radical right‐wing parties capitalise discussions around nation, this article examines Finnish lay citizens' understanding of nationhood in the context of rising right‐wing populism. Drawing on in‐depth interviews with voters of a populist party (N = 25) and using the photo‐elicitation method, this study explores how participants use time, place and emotions to construct their national identity. Through a narrative‐discursive analysis, three emotional narratives were identified—respecting the past, beloved places of identity and admiring traditional ways of living—each contributing to social identity continuity. The findings reveal the interplay between political discourses and embodied, affective meaning‐making, highlighting the importance of approaching the nation as an affective community and using image‐based methodologies to study complex national identities.
Faith over fear? Christian nationalism and cultural fears in the United States
Authors: Baker Joseph O , Whitehead Andrew L 
Published: November 2024

AbstractRecent research demonstrates strong connections between Americans' embrace of Christian nationalism and their beliefs and attitudes towards a host of salient social and cultural issues. Implicit in these explanations is that a stronger embrace of Christian nationalism signals an underlying fear of changes to the broader culture, which are perceived as leading the nation further away from a preferred, mythic past. To date, however, empirical studies have not focused explicitly on the relationship between social fears and Christian nationalism. Using a nationally representative sample of American adults, we examine the relationship between Christian nationalism and Americans' fears about immigrants, Muslims, communism, white racial replacement and gun control. We find that Christian nationalism is strongly associated with fears about ethnoracial ‘others’, as well as fears about losing economic autonomy and access to guns. Overall, our study shows that contemporary Christian nationalism in the United States is situated in a constellation of social fears about ethnoracial purity, as well as about the perceived loss of individual autonomy.
Heavy‐duty conceptual engineering
Authors: Koch Steffen , Ohlhorst Jakob 
Published: November 2024

AbstractConceptual engineering is the process of assessing and improving our conceptual repertoire. Some authors have claimed that introducing or revising concepts through conceptual engineering can go as far as expanding the realm of thinkable thoughts and thus enable us to form beliefs, hypotheses, wishes, or desires that we are currently unable to form. If true, this would allow conceptual engineers to contribute to solving stubborn problems – problems that cannot be solved with our current ways of thinking. We call this kind of conceptual engineering heavy‐duty conceptual engineering. As exciting as the idea of heavy‐duty conceptual engineering sounds, it has never been developed or defended. In this paper, we pursue a two‐fold goal. First, to offer a theory of heavy‐duty conceptual engineering that distinguishes it from other kinds of conceptual engineering; second, to show that heavy‐duty conceptual engineering is possible, both in theory and in practice, and to explain how it can be applied in the service of solving stubborn problems. The central idea is that heavy‐duty conceptual engineering can enhance the semantic expressive power of a conceptual system by the use of bootstrapping processes.
A fungal sRNA silences a host plant transcription factor to promote arbuscular mycorrhizal symbiosis
Authors: Silvestri Alessandro , Ledford William Conrad , Fiorilli Valentina , Votta Cristina , Scerna Alessia , Tucconi Jacopo , Mocchetti Antonio , Grasso Gianluca , Balestrini Raffaella , Jin Hailing , Rubio‐Somoza Ignacio , Lanfranco Luisa 
Published: November 2024

Summary
Cross‐kingdom RNA interference (ckRNAi) is a mechanism of interspecies communication where small RNAs (sRNAs) are transported from one organism to another; these sRNAs silence target genes in trans by loading into host AGO proteins. In this work, we investigated the occurrence of ckRNAi in Arbuscular Mycorrhizal Symbiosis (AMS).
We used an in silico prediction analysis to identify a sRNA (Rir2216) from the AM fungus Rhizophagus irregularis and its putative plant gene target, the Medicago truncatula MtWRKY69 transcription factor. Heterologous co‐expression assays in Nicotiana benthamiana, 5′ RACE reactions and AGO1‐immunoprecipitation assays from mycorrhizal roots were used to characterize the Rir2216–MtWRKY69 interaction. We further analyzed MtWRKY69 expression profile and the contribution of constitutive and conditional MtWRKY69 expression to AMS.
We show that Rir2216 is loaded into an AGO1 silencing complex from the host plant M. truncatula, leading to cleavage of a host target transcript encoding for the MtWRKY69 transcription factor. MtWRKY69 is specifically downregulated in arbusculated cells in mycorrhizal roots and increased levels of MtWRKY69 expression led to a reduced AM colonization level.
Our results indicate that MtWRKY69 silencing, mediated by a fungal sRNA, is relevant for AMS; we thus present the first experimental evidence of fungus to plant ckRNAi in AMS.
Valuing behavioral interventions for obesity reduction: A scoping review of economic models
Authors: McLaughlin Joanna , Sillero‐Rejon Carlos , Moore Theresa H. M. , McLeod Hugh 
Published: November 2024

SummaryPolicymakers require health economic modeling to guide their decision‐making over the choice of interventions for obesity. This scoping review was undertaken to report on the health economic models in use for estimating the value of behavioral interventions (individual or population level) for obesity reduction. Electronic databases (MEDLINE, Embase, PsycINFO, EconLit, and Web of Science) were searched for publications meeting inclusion criteria from January 2015 to May 2023. Seventy‐three studies were included, using 44 health economic models between them. When considered against the expert recommendations for modeling of this type, only four models (9%) met all five key elements. The element most commonly unfulfilled was the use of a microsimulation modeling approach (41%, n = 18), followed by model validation (46%, n = 20). A majority of models met each of the other elements: use of a lifetime horizon (59%, n = 26), inclusion of key health events (66%, n = 29), and a risk equation approach to event simulation (71%, n = 31). In addition, under half of the studies considered health inequalities in their reporting. Continued proliferation of models with inadequate time horizons, breadth of obesity‐related health conditions, and perspectives on costs and outcomes risks underestimation of the benefits of longer term interventions and impacts on health inequalities.
Against anti‐fanaticism
Authors: Tarsney Christian 
Published: November 2024

AbstractShould you be willing to forego any sure good for a tiny probability of a vastly greater good? Fanatics say you should, anti‐fanatics say you should not. Anti‐fanaticism has great intuitive appeal. But, I argue, these intuitions are untenable, because satisfying them in their full generality is incompatible with three very plausible principles: acyclicity, a minimal dominance principle, and the principle that any outcome can be made better or worse. This argument against anti‐fanaticism can be turned into a positive argument for a weak version of fanaticism, but only from significantly more contentious premises. In combination, these facts suggest that those who find fanaticism counterintuitive should favor not anti‐fanaticism, but an intermediate position that permits agents to have incomplete preferences that are neither fanatical nor anti‐fanatical.
Got alt hui. Some considerations on the German dialogue between Massimiliano Sforza and Maximilian I in the Liber Iesus (Milan, Archivio Storico Civico e Biblioteca Trivulziana, Cod. Triv. 2163)☆
Authors: Berger Michael 
Published: November 2024

AbstractThe so‐called Liber Iesus, a Latin prayer book commissioned for the young Massimiliano Sforza by his father Ludovico il Moro in the 1490s, features a splendid miniature depicting a meeting between the child count and Emperor Maximilian I. It is accompanied by a brief dialogue in German with an interlinear version in Italian on the topic of the Milanese‐Imperial alliance on the opposite page. Although the presence of a German version has often been discussed in research, no linguistic analysis has been conducted; statements about the dialogue's contents have apparently always been based on the Italian version. However, it has gone unnoticed that the German text shows a number of idiosyncratic forms that greatly limit its comprehensibility. This finding raises doubts about the common interpretation of the dialogue as a transcript or learning aid for a factual meeting between the two protagonists. In this paper, the language of the dialogue is analysed and the possible genesis of the text in its written form is reconstructed. Moreover, the potential functions of the dialogue beyond the communicative value of the language are discussed.
Utility of acid citrate dextrose‐acidification for platelet volume reduction protocols in the transfusion service
Authors: Jung Yujung , Khan Jenna , Nester Theresa , Usaneerungrueng Chomkan , Stolla Moritz , Barry Dwight , Taroc Ann‐Marie , Ricci Kristin , Saifee Nabiha H. 
Published: November 2024

AbstractBackgroundVolume‐reduced platelets can minimize circulatory overload, allergic transfusion reactions, or out‐of‐group plasma infusion. Our center adopted a volume reduction protocol that includes acidification with acid citrate dextrose solution A (ACD‐A) before centrifugation and without any rest period prior to resuspension allowing a better turnaround time for platelet issue.Study Design and MethodsThis report compares corrected count increments (CCIs) from full‐volume and ACD‐A acidified volume‐reduced human platelets in a retrospective study at a single hospital and in a mouse model.ResultsAt a pediatric tertiary care hospital, 530 patients received conventional apheresis platelets during the 20‐month study period. Among all patients, the expected 4‐h mean CCI was 9.8 (95% CI: 8.7, 10.9) for full‐volume platelets, and 8.8 (95% CI: 7.3, 10.6) for ACD‐acidified volume‐reduced platelets (p = .29). A statistically significant difference (p = .01) was identified in the expected 24‐h mean CCI: 6.3 (95% CI: 5.5–7.0) with full‐volume platelet, 4.7 (95% CI: 3.6–6.0) with ACD‐acidified volume‐reduced platelet. Limiting CCI calculations to patients with Hematology/Oncology/Hematopoietic Progenitor Cell Transplant diagnosis (n = 296, 56%) indicated a statistically significant difference in both 4‐ and 24‐h predicted CCIs, showing lower CCIs in ACD‐acidified volume‐reduced platelet, although these were still similar to the CCIs observed in all patients and considered to be clinically acceptable responses similar to other volume reduction protocols. The recovery of count‐adjusted, volume‐reduced platelets was significantly lower in mice, suggesting a procedure‐related defect.DiscussionACD‐A acidification of platelets before volume reduction decreases turnaround time for platelet issue and provides clinically allowable 4‐h and 24‐h platelet increments.
Evaluation of 3D‐printed patient‐specific guides to facilitate fluoroscopic‐assisted Kirschner wire stabilization of simulated capital physeal fractures in 3D‐printed dog femur models
Authors: Deveci Mehmet Zeki Yilmaz , Lewis Daniel D. , Worden Natalie J. , Johnson Matthew D. , Scheuermann Logan M. , Kim Stanley E. , Peterson Lindsay C. 
Published: November 2024

AbstractObjectiveTo compare the efficiency and accuracy of freehand and three‐dimensionally printed (3DP) guide‐facilitated fluoroscopic‐assisted Kirschner wire placement in the femoral capitis performed by novice and experienced surgeons.Sample population3DP models of five skeletally immature dog femurs were replicated.MethodsVirtual surgical planning was done to position three parallel, virtual Kirschner wires inserted from the lateral subtrochanteric surface of the femur, coursing proximomedially through the femoral neck to engage the central capitis without penetrating the subchondral bone. Patient‐specific guides were designed and 3DP to facilitate optimal Kirschner wire placement in each femoral model. Four faculty surgeons and four surgery residents performed freehand fluoroscopic‐assisted wire placement in the femoral models. Wire placement was repeated ≥1 month later using the 3DP guides. Surgical time, number of times wires were redirected, number of fluoroscopy images acquired and Likert scores from the participants were recorded. Post‐procedural CTs of the femur models were used to assess wire placement by 3D analysis.ResultsThe number of fluoroscopy images was greater (p < .001) and procedure time was longer (p < .001) for freehand applications, while Likert scores were greater (p < .001) for 3DP‐guide applications. Wire placement was more accurate with 3DP guides. Subchondral bone penetration occurred more frequently during freehand applications (p < .01).Conclusion3DP patient‐specific guides resulted in faster, simpler, and more accurate Kirschner wire placement than freehand placement for both novice and experienced surgeons. Further cadaveric and clinical studies are warranted to evaluate the utility of 3DP patient‐specific guides to facilitate minimally invasive fluoroscopic‐assisted femoral capital physeal fracture stabilization in dogs.
The transportation of embedded inversion in world Englishes
Authors: Amador‐Moreno Carolina P. 
Published: November 2024

AbstractThe present study uses private correspondence to investigate the use of embedded inversion on both sides of the Atlantic as an illustration of the spread of spoken/conversational features through writing. The paper discusses the use of embedded inversion in Irish English (IrE) and briefly compares its occurrence in other varieties of English during the 19th century. The data come from CORIECOR, the Corpus of Irish English Correspondence, which contains emigrant letters written to and by Irish emigrants from 1760 to 1940. The letters were sent mainly between Ireland and other countries such as the United States, Canada, Great Britain, New Zealand, Australia, and Argentina, and therefore provide an empirical base for studies of historical change. By using corpus linguistics techniques, we analyze possible connections between American English and IrE. The occurrence of embedded inversion in CORIECOR is compared with other historical corpora such as the Corpus of Historical American English, which provides data from one of the main destinations of Irish emigrants.
Efficacy and safety of fezolinetant for moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy: phase 3b randomised controlled trial
Authors: Schaudig Katrin , Wang Xuegong , Bouchard Céline , Hirschberg Angelica Lindén , Cano Antonio , Shapiro C M Marla , Stute Petra , Wu Xi , Miyazaki Kentaro , Scrine Ludmila , Nappi Rossella E 
Published: November 2024

Abstract

Objectives
To assess the efficacy and safety of the non-hormonal, neurokinin 3 receptor antagonist, fezolinetant, to treat moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy.

Design
Phase 3b randomised controlled trial.

Setting
16 countries.

Participants
453 individuals aged 40-65 years with moderate-severe vasomotor symptoms associated with menopause who were considered unsuitable candidates for hormone therapy (contraindicated, caution (based on medical history), stoppers (previous discontinuation of hormone therapy), or averse (informed choice not to use hormone therapy)) were randomised to receive fezolinetant (n=227) or placebo (n=226).

Intervention
Fezolinetant 45 mg or placebo once daily for 24 weeks.

Main outcome measures
The primary endpoint was mean change in daily frequency of moderate-severe vasomotor symptoms from baseline to week 24. Secondary endpoints were mean change in symptom severity, sleep disturbance using the Patient-Reported Outcome Measurement Information System Sleep Disturbance Short Form (PROMIS SD-SF) 8b total score, and safety.

Results
370 (81.7%) participants completed the study (fezolinetant=195, placebo group=175). The safety and full analysis sets comprised 452 participants who received at least one dose of study drug. Mean age was 54.5 (standard deviation 4.7) years and most of the participants (435 (96.7%) were white and categorised as either hormone therapy averse (168 (37.2%)) or caution (165 (36.5%)). At week 24, fezolinetant significantly reduced the frequency (least squares mean difference –1.93, 95% confidence interval (CI) –2.64 to –1.22; P<0.001) and severity of vasomotor symptoms (–0.39, –0.57 to –0.21; P<0.001). At week 24, the fezolinetant group had a greater reduction in sleep disturbance (PROMIS SD-SF 8b total score) compared with placebo (–2.5, –3.9 to –1.1; P<0.001). Improvements over placebo were observed as early as week 1. Both groups showed similar incidences of treatment emergent adverse events (TEAEs, 147 (65.0%) in the fezolinetant group, 138 (61.1%) in the placebo group) and serious TEAEs (10 (4.4%) and 8 (3.5%), respectively). The most common TEAEs in the fezolinetant group were covid-19 (30 (13.3%)), headache (20 (8.8%)), and fatigue (13 (5.8%)).

Conclusions
Fezolinetant was efficacious and well tolerated over a six month period for treating moderate-severe vasomotor symptoms in individuals considered unsuitable for hormone therapy. These results highlight the utility of fezolinetant as an effective treatment option for those who have contraindications to or choose not to use hormone therapy.

Trial registration

ClinicalTrials.gov
NCT05033886
; EudraCT 2021-001685-38.
Visual Upward/Downward Motion Elicits Fast and Fluent High-/Low-Pitched Speech Production
Authors: Suzuki Yusuke , Nagai Masayoshi 
Published: November 2024

Abstract
Participants tend to produce a higher or lower vocal pitch in response to upward or downward visual motion, suggesting a pitch–motion correspondence between the visual and speech production processes. However, previous studies were contaminated by factors such as the meaning of vocalized words and the intrinsic pitch or tongue movements associated with the vowels. To address these issues, we examined the pitch–motion correspondence between simple visual motion and pitched speech production. Participants were required to produce a high- or low-pitched meaningless single vowel [a] in response to the upward or downward direction of a visual motion stimulus. Using a single vowel, we eliminated the artifacts related to the meaning, intrinsic pitch, and tongue movements of multiple vocalized vowels. The results revealed that vocal responses were faster when the pitch corresponded to the visual motion (consistent condition) than when it did not (inconsistent condition). This result indicates that the pitch–motion correspondence in speech production does not depend on the stimulus meaning, intrinsic pitch, or tongue movement of the vocalized words. In other words, the present study suggests that the pitch–motion correspondence can be explained more parsimoniously as an association between simple sensory (visual motion) and motoric (vocal pitch) features. Additionally, acoustic analysis revealed that speech production aligned with visual motion exhibited lower stress, greater confidence, and higher vocal fluency.