bluuebunny/crossref_metadata_2025_split huggingface dataset:
PTEN influences insulin and lipid metabolism in bovine hepatocytes in vitro
Authors: Deng Qinghua , Ma Dehui , Sun Guoquan , Yuan Xue , Wang Zhe , Liu Guowen 
Published: March 2019

AbstractDairy cows with fatty liver or ketosis display decreased insulin sensitivity and defects in the insulin receptor substrate (IRS)/PI3K/AKT signaling pathway. Phosphatase and tensin homolog (PTEN) is a well-known tumor suppressor and also a negative regulator of insulin signaling and peripheral insulin sensitivity. We investigated the hypothesis that PTEN may affect the insulin pathway-mediated hepatic glucose and lipid metabolism in dairy cows. Adenovirus vectors that over-express and silence PTEN were constructed, and then transfected into hepatocytes isolated from calves to investigate the effect of PTEN on PI3K/AKT signaling pathway. PTEN silencing increased the phosphorylation of AKT and the expression of PI3K but decreased the phosphorylation of IRS1, which increased the phosphorylation levels of glycogen synthase kinase-3β (GSK-3β) and expression of sterol regulatory element-binding protein-1c (SREBP-1c). Increased GSK-3β phosphorylation further up-regulated expression of the key enzymes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6-Pase) involved in gluconeogenesis. Furthermore, the expression of SREBP-1c target gene fatty acid synthase (FAS) also increased significantly. We further showed that PTEN over-expression could reverse the above results. PTEN negatively regulates the enzymes involved in hepatic gluconeogenesis and lipid synthesis, which suggests that PTEN may be a therapeutic target for ketosis and fatty liver in dairy cows.
Parapharyngeal abscess secondary to lymphovenous malformation
Authors: Khosla S , Caton N , Zhang T-T , Davies-Husband C R 
Published: March 2019

AbstractBackgroundDeep neck space abscesses are an uncommon but life-threatening emergency presentation to the ENT surgeon because of potential acute airway compromise.ObjectiveThis paper presents a novel case of a palatine tonsillar, low-flow, lymphovenous malformation pre-disposing to multifocal deep neck space collections and resultant acute airway compromise.
Epidemiological evaluation of human papillomavirus genotypes and their associations in multiple infections
Authors: Del Prete Raffaele , Ronga Luigi , Magrone Raffaella , Addati Grazia , Abbasciano Angela , Di Carlo Domenico , Miragliotta Giuseppe 
Published: March 2019

AbstractThe aim of this study was to determine the frequency of multiple type human papillomavirus (HPV) infections, and whether any types are involved in multiple HPV-type infections (mHPV) more or less frequently than expected. From January 2012 to February 2018, 2848 cervico-vaginal swabs were analysed in the UOC Microbiology and Virology of Policlinico of Bari, Italy. HPV DNA detection was performed using initially nested-polymerase chain reaction (PCR) and subsequently multiplex real-time PCR assay. 1357/2848 samples (47.65%) were HPV DNA positive and 694/1357 (51.14%) showed mHPVs. The median number of mHPVs was 2 (interquartile range: 2–3). HPV-types more frequently detected were 42 (9.97%), 16 (8.92%), 53 (7.23%) and 31 (7.16%). Each detected HPV-type was involved in mHPVs in more than 50% of cases. Statistical analysis showed significant associations for all HPV-types except for 33, 43, 51, 58 and 82 HPV-types. The major number of significant pairwise associations were detected for the types 42 and 70. Only positive associations were detected. Further data are necessary to evaluate the clinical impact of the single combinations.
Epidemiological, clinical and laboratory characteristics of acute Q fever in an endemic area in Israel, 2006–2016
Authors: Reisfeld S. , Hasadia Mhamed S. , Stein M. , Chowers M. 
Published: March 2019

AbstractOur purpose was to describe the clinical, epidemiological and laboratory characteristics of patients hospitalised with acute Q fever in an endemic area of Israel. We conducted a historical cohort study of all patients hospitalised with a definite diagnosis of acute Q fever, and compared them to patients suspected to have acute Q fever, but diagnosis was ruled out. A total of 38 patients had a definitive diagnosis, 47% occurred during the autumn and winter seasons, only 18% lived in rural regions. Leucopaenia and thrombocytopaenia were uncommon (16% and 18%, respectively), but mild hepatitis was common (mean aspartate aminotransferase 76 U/l, mean alanine aminotransferase 81 U/l). We compared them with 74 patients in which acute Q fever was ruled out, and found that these parameters were not significantly different. Patients with acute Q fever had a shorter hospitalisation and they were treated more often with doxycycline than those without acute Q fever (6.4vs. 14 days,P= 0.007, 71%vs. 38%,P= 0.001, respectively). In conclusion, acute Q fever can manifest as an unspecified febrile illness, with no seasonality. We suggest that in endemic areas, Q fever should be considered in the differential diagnosis in any febrile patient with risk factors for a persistent infection.
Comparison of clinical characteristics of patients with Mycobacterium avium complex disease by gender
Authors: Ikuyama Y. , Ushiki A. , Akahane J. , Kosaka M. , Kitaguchi Y. , Urushihata K. , Yasuo M. , Yamamoto H. , Hanaoka M. 
Published: March 2019

AbstractThe clinical characteristics of male patients with pulmonary Mycobacterium avium complex disease have not been clearly defined. We aimed to clarify the clinical characteristics of male patients with pulmonary Mycobacterium avium complex disease compared with female patients.We retrospectively reviewed the medical records of patients with pulmonary Mycobacterium avium complex disease who visited the outpatient clinic of the Shinshu University Hospital between 2003 and 2016 and compared the clinical characteristics of male and female patients.A total of 234 patients with pulmonary Mycobacterium avium complex disease were identified (68 men and 166 women). Male patients were significantly older than female patients. Blood examination results showed that the lymphocyte count, total protein level and albumin level were significantly lower in men than in women. Chest imaging findings were broadly categorised into the fibrocavitary and nodular bronchiectasis types. There were no significant differences in chest imaging findings and the time from diagnosis to disease exacerbation between men and women.During the study period, the incidence of the nodular bronchiectasis type of pulmonary Mycobacterium avium complex disease in male patients increased compared with previous reports. Men had no difference in time to exacerbation compared with women.
The power of working longer
Authors: Bronshtein Gila , Scott Jason , Shoven John B. , Slavov Sita Nataraj 
Published: March 2019

AbstractThis paper compares the relative strengths of working longer vs. saving more in terms of increasing a household's affordable, sustainable standard of living in retirement. Both stylized households and actual households from the Health and Retirement Study are examined. We assume that workers commence Social Security benefits when they retire. The basic result is that delaying retirement by 3–6 months has the same impact on the retirement standard of living as saving an additional one-percentage point of labor earnings for 30 years. The relative power of saving more is even lower if the decision to increase saving is made later in the work life. For instance, increasing retirement saving by one percentage point 10 years before retirement has the same impact on the sustainable retirement standard of living as working between 1 and 2 months longer. The calculations of the relative power of working longer and saving more are done for a wide range of realized rates of returns on saving, for households with different income levels, and for singles as well as married couples. The results are quite invariant to these circumstances.
Phenotypic analysis of leaf colours from the USDA, ARS sweetpotato (Ipomoea batatas) germplasm collection
Authors: Jackson D. Michael , Harrison H. F. , Jarret R. L. , Wadl P. A. 
Published: March 2019

AbstractLeaf colour characteristics of 730 sweetpotato,Ipomoea batatas(L.) Lam. (Convolvulaceae), plant introduction (PI) accessions from the USDA sweetpotato germplasm collection were evaluated during 2012–2014. Colorimetry data for the abaxial and adaxial leaf surfaces were recorded using a tristimulus colorimeter and the CIE 1976 L*a*b* and CIE L*C*h* colour spaces. Most accessions (725 of 730 PIs) had dark-to-medium green leaves, but two PIs had totally purple leaves, and three PIs had yellow or yellow-green (chartreuse) leaves. For mature, field-grown green leaves, values for the red-green coordinate (a*) averaged −12.4 for the adaxial and −10.4 for the abaxial leaf surface. Values for the blue-yellow coordinate (b*) averaged 17.2 for the adaxial and 17.3 for the abaxial leaf surface. Hue angle (h*) for green leaves averaged 120.9° for the adaxial and 126.2° for the abaxial leaf surface. Colour saturation (Chroma, C*) averaged 21.3 for the adaxial and 20.2 for the abaxial leaf surface. Lightness (L*) averaged 35.4 for the adaxial and 47.2 for the abaxial leaf surface of green leaves. Late in the season, over one-half (53.9%) of the 730 PIs showed some level of purple pigmentation in the leaf lamina. Late-season purple leaves were collected and colour coordinates were recorded for 118 PIs grown in the field. For purple leaves, values for a*, b*, C*, L* and h* averaged 2.3, 6.2, 7.9, 28.2 and 64.4° for the adaxial surface and −1.0, 12.7, 13.9, 43.1 and 87.0° for the abaxial leaf surface, respectively.
Cognitive behavioural therapy for psychosis targeting trauma, voices and dissociation: a case report
Authors: McCartney Laura , Douglas Maggie , Varese Filippo , Turkington Douglas , Morrison Anthony P. , Dudley Robert 
Published: March 2019

AbstractTrauma and dissociation may be important factors contributing to the experiences of distressing voice hearing. However, there is scant mention of how to target and treat such processes when working with people with psychosis. This case study reports on an initial attempt to work with dissociation and trauma memories in a person with voices. A single case approach was used, with standardized measures used before, during and after 24 sessions of cognitive therapy, and at 6-month follow-up. In addition, session-by-session measures tracked frequency and distress associated with voices and dissociation. The participant reported significant improvements in terms of reduced frequency and distress of dissociation, and voice hearing, as well as improvement in low mood at the end of treatment. At follow-up there were enduring benefits in terms of dissociation and trauma-related experiences, as well as broad recovery but not of change in voices. This case illustrated the potential benefit of targeting dissociation and exposure to trauma memories in producing general symptom improvement and specific reductions in dissociation and voice hearing at end of treatment.
Design and development of wide band dual-polarized magneto electric dipole antenna for mobile communications
Authors: Pollayi Lakshminarayana , Dasari Rama Krishna , Pandharipande Vijay M. 
Published: March 2019

AbstractA shorted magneto electric dipole with orthogonal dual polarization is designed for modern wireless communications. The proposed antenna is a wideband dual-polarized antenna consisting of magneto electric dipoles, which are fed by novel hook-shaped strip feeds. The antenna proposed in this paper is simulated using EM simulation software called high-frequency structure simulator. The simulated and measured results are presented. This antenna achieves 45.4% of impedance bandwidth of −10 dB RL for frequency range from 1.7 to 2.7 GHz. This frequency range covers the wireless communications applications like GSM 1800/1900, WCDMA, Bluetooth, Wi-Fi, etc.
Ripple Effects of Surface Acting: A Diary Study among Dual-Earner Couples
Authors: Bakker Arnold B. , Sanz-Vergel Ana Isabel , Rodríguez-Muñoz Alfredo , Antino Mirko 
Published: March 2019

AbstractThis study among 80 dual-earner couples examines the ripple effects of emotional labour – on a daily basis. Specifically, we propose that employees who engage in surface acting at work drain their energetic resources, and undermine their own relationship satisfaction. Drawing upon conservation of resources (COR) theory, we predicted that work-related exhaustion would mediate the relationship between surface acting at work and at home. In addition, we hypothesized that employees’ emotional energy in the evening would mediate the relationship between surface acting at home and (actor and partner) satisfaction with the relationship. Participants filled in a survey and a diary booklet during five consecutive working days (N= 80 couples,N= 160 participants x 5 days,N= 800 occasions). The hypotheses were tested with multilevel analyses, using the actor–partner interdependence model. Results showed that daily work-related exhaustion partially mediated the relationship between daily surface acting at work and at home. As hypothesized, daily surface acting at home influenced own and partner’s daily relationship satisfaction through reduced daily emotional energy. These findings offer support for COR theory, and have important implications for organizations that encourage emotion regulation.
Patterns of Precarity: Historical Trajectories of Vietnamese Labour Mobility
Authors: Tappe Oliver 
Published: March 2019

AbstractIn past and present Vietnam, the dialectic of precarity and resilience shapes the everyday lives of mobile labourers. Vietnamese labour mobility is characterised by an interplay between precariousness ‘at home’ and the uncertainties of migration. The paper aims to highlight continuities and contingencies in the longue durée of Vietnamese work migration through a historical contextualisation of precarious labour relations. Both colonial ‘coolie’ workers and present-day labour migrants share similar experiences, for example socioeconomic marginalisation in the regions of origin, opportunity and risk, and emerging translocal identities.
A Year‐Round Subseasonal‐to‐Seasonal Sea Ice Prediction Portal
Authors: Wayand N. E. , Bitz C. M. , Blanchard‐Wrigglesworth E. 
Published: March 2019

AbstractA significant barrier to understanding and quantifying current skill of Arctic sea ice forecasts is a lack of a central database to enable model evaluation and intercomparison. This study addresses this issue by introducing a central server and web portal housing multimodel ensemble forecasts. We present an overview of the portal and provide an analysis of 2018 forecast skill. Among the 16 participating models, forecasts of sea ice concentration varied widely; yet the multimodel mean generally offered skillful forecasts for up to 5 months. Models that assimilated observed concentrations with more advanced methods performed better on average than other models. Similarly, one model that incorporated satellite‐based sea ice thickness thereafter compared most favorably with thickness measured along IceBridge flight tracks. These results highlight the benefits from multimodel predictions and assimilating sea ice variables and the insights gained from near‐real‐time evaluation of operational forecasts.
Barotropic Kelvin Wave‐Induced Bottom Boundary Layer Warming Along the West Antarctic Peninsula
Authors: Webb D. J. , Holmes R. M. , Spence P. , England M. H. 
Published: March 2019

AbstractIntrusions of warm circumpolar deep water onto the Antarctic continental shelf are thought to drive accelerated loss of Antarctic glacial ice mass by triggering melt at the ice shelf grounding line. However, the mechanisms responsible for driving on‐shelf circumpolar deep water intrusions are not well understood. Here we examine how sea surface height (SSH) anomalies propagating around the Antarctic coastline as coastal‐trapped waves can drive warm water intrusions through changes in bottom Ekman transport. A wind perturbation motivated by the recent intensification and poleward shift of the southern annular mode during its positive phase is applied over Eastern Antarctica between 20°E and 120°E in two global ocean sea‐ice models (1/4° and 1/10°) and a single‐layer shallow water model. The changes in winds generate a drop in coastal SSH that propagates around Antarctica as a barotropic Kelvin wave. The SSH drop is accompanied by a barotropic flow, which alters the bottom stress, generating an onshore transport of warm water wherever thermal gradients are favorable. We estimate the resulting anomalous bottom Ekman flow and use temperature gradients calculated from the Southern Ocean State Estimate, along with the 1/4° and 1/10° models, to evaluate the resultant heat advection. We find that this mechanism can drive warming of up to 0.7 °C along the West Antarctic Peninsula within a year, depending on the mean state of the cross‐shelf temperature gradient and the barotropic flow strength. Over longer time scales, warming eventually ceases due to saturation of the SSH field and arrest of the Ekman transport by buoyancy forces.
Atlantic Water Pathways Along the North‐Western Svalbard Shelf Mapped Using Vessel‐Mounted Current Profilers
Authors: Menze Sebastian , Ingvaldsen Randi B. , Haugan Peter , Fer Ilker , Sundfjord Arild , Beszczynska‐Moeller Agnieszka , Falk‐Petersen Stig 
Published: March 2019

AbstractA large amount of warm Atlantic water (AW) enters the Arctic as a boundary current through Fram Strait (West Spitsbergen Current [WSC]) and is the major oceanic heat source to the Arctic Ocean. Along the north‐western Svalbard shelf, the WSC splits into the shallow Svalbard Branch, the Yermak Branch that follows the slope of the Yermak Plateau, and the Yermak Pass Branch flowing across the plateau. The WSC has previously been studied using moorings, dedicated oceanographic transects, and models. In this study, we mapped the circulation patterns and AW flow around Svalbard using Vessel‐Mounted Acoustic Doppler Current Profiler data from multiple surveys during four consecutive summers (2014–2017). Despite the scattered nature of this compiled data set, persistent circulation patterns could be discerned. Spatial interpolation showed a meandering boundary current west of Svalbard and a more homogeneous AW flow, centered around the 1,000‐m isobath north of Svalbard. In all summers, we observed a northward jet between 79 and 80°N and the 1,000‐ and 500‐m isobaths, before the WSC divided into the three branches. North of Svalbard, the shallow Svalbard Branch reunited with the Yermak Pass Branch between 10 and 15°E and a part of the AW circulated within Hinlopen Trench. The calculated volume transport of 2 Sv in the upper 500 m compares well with model results and previous observations. Our results further show that the Yermak Pass Branch can be as important as the Svalbard Branch in transporting AW across the Yermak Plateau during summer.
The Contributions of Winter Cloud Anomalies in 2011 to the Summer Sea‐Ice Rebound in 2012 in the Antarctic
Authors: Wang Yunhe , Yuan Xiaojun , Bi Haibo , Liang Yu , Huang Haijun , Zhang Zehua , Liu Yanxia 
Published: March 2019

AbstractUnlike the rapid decline of Arctic sea ice in the warming climate, Antarctic sea‐ice extent exhibits a modest positive trend in the period of near four decades. In recent years, the fluctuation in Antarctic sea ice has been strengthened, including a decrease toward the lowest sea‐ice extent in February 2011 for the period of 1978–2016 and a strong rebound in the summer of 2012. The sea‐ice recovery mainly occurs in the Weddell Sea, Bellingshausen Sea, Amundsen Sea, southern Ross Sea, and the eastern Somov Sea. This study offers a new mechanism for this summertime sea‐ice rebound. We demonstrate that cloud‐fraction anomalies in winter 2011 contributed to the positive Antarctic sea‐ice anomaly in summer 2012. The results show that the negative cloud‐fraction anomalies in winter 2011 related to the large‐scale atmospheric circulation resulted in a substantial negative surface‐radiation budget, which cooled the surface and promoted more sea‐ice growth. The sea‐ice growth anomalies due to the negative cloud forcing propagated by sea‐ice motion vectors from September 2011 to January 2012. The distribution of the sea‐ice anomalies corresponded well with the sea‐ice concentration anomalies in February 2012 in the Weddell Sea and eastern Somov Sea. Thus, negative cloud‐fraction anomalies in winter can play a vital role in the following summer sea‐ice distribution.
Incomplete Anger‐Weber Functions: A Class of Special Functions for Electromagnetics
Authors: Caratelli Diego 
Published: March 2019

AbstractA novel class of special functions for electromagnetics is presented. Formed by the incomplete Anger‐Weber functions, this class conveniently allows solving electromagnetic problems involving truncated circular electromagnetic structures. The definition of these functions is here introduced, and the relevant analytical properties are derived. The definition is such that the interrelationships between the incomplete functions parallel, as far as is feasible, those for canonical Anger‐Weber functions.
Publisher Correction: Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling
Authors: Wang Shanshan , Zhu Mingyue , Wang Qiaoyun , Hou Yuli , Li Lei , Weng Honglei , Zhao Yan , Chen Dexi , Guo Junli , Ding Huiguo , Li Mengsen 
Published: March 2019

The article published with errors in the authors’ information. The correct ordering and designations for corresponding /first authors are shown here.
High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy
Authors: Bowler Mathew , Kong Dong , Sun Shufeng , Nanjundappa Rashmi , Evans Lauren , Farmer Veronica , Holland Andrew , Mahjoub Moe R. , Sui Haixin , Loncarek Jadranka 
Published: March 2019

AbstractCentrioles are vital cellular structures that form centrosomes and cilia. The formation and function of cilia depends on a set of centriole’s distal appendages. In this study, we use correlative super resolution and electron microscopy to precisely determine where distal appendage proteins localize in relation to the centriole microtubules and appendage electron densities. Here we characterize a novel distal appendage protein ANKRD26 and detail, in high resolution, the initial steps of distal appendage assembly. We further show that distal appendages undergo a dramatic ultra-structural reorganization before mitosis, during which they temporarily lose outer components, while inner components maintain a nine-fold organization. Finally, using electron tomography we reveal that mammalian distal appendages associate with two centriole microtubule triplets via an elaborate filamentous base and that they appear as almost radial finger-like protrusions. Our findings challenge the traditional portrayal of mammalian distal appendage as a pinwheel-like structure that is maintained throughout mitosis.