bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring geriatric assessment‐driven rehabilitation referral patterns and its influence on functional outcomes and survival in older adults with advanced cancer
Authors: Brick Rachelle , Jensen‐Battaglia Marielle , Streck Brennan P. , Page Lindsey , Tylock Rachael , Cacciatore Jenna , Mustian Karen , Khatri Jamil , Giguere Jeff , Dib Elie G. , Mohile Supriya , Culakova Eva 
Published: November 2024

AbstractBackgroundOlder adults with advanced cancer experience functional disability that warrants rehabilitation services; however, evidence indicates inconsistencies in referral. The purpose was to (1) identify predictors of geriatric assessment (GA)‐driven referrals to rehabilitation services and (2) explore associations between referral and change in function, health‐related quality of life (HRQoL), and overall survival among older adults with advanced cancer.MethodsThis was a secondary analysis (NCT020107443, UG1CA189961) of a nationwide GA clinical trial. Patients were older adults with advanced cancer who had at least one GA‐defined physical performance or functional status impairment. Primary outcomes were oncologist‐initiated discussion about or referral to rehabilitation services after the GA (Aim 1) and decline in activities of daily living (ADL), Instrumental ADL (IADL), and HRQoL within 3 months, and overall survival at 1 year (Exploratory Aims). Analyses included multivariable logistic regression and Cox proportional hazards models. Demographic and clinical factors were controlled for by using 1:1 propensity score matching.ResultsIn total 265 patients were analyzed. After adjustment, impaired cognition (odds ratio [OR] = 2.25, p = 0.01), Karnofsky score indicating disability (OR = 2.86, p < 0.01), and receipt of monoclonal antibodies (OR = 1.95, p = 0.04) were associated with higher odds of referral. In contrast, polypharmacy was associated with lower odds of referral (OR = 0.31, p < 0.01). Referred patients were less likely to decline in ADL (OR 0.30, p = 0.07) and IADL (OR 0.64, p = 0.35), but more likely to decline in HRQoL (OR 1.20, p = 0.67) and have worse survival (HR 1.18, p = 0.62).ConclusionsCancer treatment, polypharmacy, cognition, and disability status likely influence oncologists' decision to refer for rehabilitation. Referral was not independently associated with change in functional disability, HRQoL, or survival. Future studies should evaluate patients' utilization of rehabilitation services post‐referral and determine whether dose/timing of rehabilitation services influence clinical outcomes.
Dampening the Financial Accelerator? Direct Lenders and Monetary Policy
Authors: BANERJEE RYAN , SERENA JOSE‐MARIA 
Published: November 2024

AbstractDirect lenders, nonbank credit intermediaries with low leverage, have become increasingly important players in corporate loan markets. In this paper, we investigate the role they play in the monetary policy transmission mechanism, using U.S. dollar syndicated loan data covering the 1997–2018 period. We show that direct lenders are more likely to join loan syndicates whenever monetary policy announcements trigger a contraction in borrowers' net worth irrespective of the directional change in interest rates. Thus, our findings suggest that direct lenders dampen the financial accelerator channel of monetary policy.
A Psychosocial Exploration of Augmented Reality and Virtual Reality Apps in Cosmetic Procedures
Authors: Haykal Diala , Cartier Hugues , Flament Frederic 
Published: November 2024

ABSTRACTBackgroundThe integration of augmented reality (AR) and virtual reality (VR) technologies into cosmetic dermatology offers new avenues for enhancing patient engagement, satisfaction, and decision‐making. These immersive tools allow patients to better visualize the outcomes of procedures before treatment, improving communication with physicians and increasing confidence in cosmetic interventions. Despite the promise these technologies hold, there remain concerns regarding their accessibility, technical limitations, ethical challenges, and the potential for algorithmic bias. This commentary aims to explore the psychosocial implications of AR and VR in cosmetic consultations, focusing on their benefits and potential drawbacks.MethodsThis commentary is based on a comprehensive review of literature on AR and VR applications in cosmetic procedures. The focus is on the psychosocial impact of these technologies, highlighting their influence on patient expectations, satisfaction, and decision‐making. Studies that evaluate the integration of AR and VR into cosmetic consultations were analyzed to assess the benefits and challenges associated with these tools.ResultsThe analysis revealed that AR and VR significantly enhance patient involvement by allowing real‐time visualization of treatment outcomes, which improves both understanding and satisfaction. Patients reported feeling more informed and confident in their decisions when using these tools during consultations. Furthermore, these technologies allow physicians to offer more personalized and detailed consultations, thus improving communication and alignment of expectations. However, several challenges remain: AR and VR technologies are expensive, their use can lead to discomfort (cybersickness), and algorithmic bias may skew patient perceptions, particularly in underrepresented demographic groups. There are also ethical concerns about data security and transparency of the algorithms used in these systems.ConclusionAR and VR hold tremendous potential to revolutionize patient care in cosmetic dermatology by enhancing engagement, improving decision‐making, and increasing overall patient satisfaction. Nonetheless, the full realization of these benefits will require addressing technical and ethical challenges through ongoing research, regulatory oversight, and collaboration between medical professionals and technology developers.
The Phytophthora infestans effector Pi05910 suppresses and destabilizes host glycolate oxidase StGOX4 to promote plant susceptibility
Authors: Zhang Peiling , Li Jinyang , Gou Xiuhong , Zhu Lin , Yang Yang , Li Yilin , Zhang Yingqi , Ding Liwen , Ansabayeva Assiya , Meng Yuling , Shan Weixing 
Published: November 2024

Abstract
Phytophthora infestans is a notorious oomycete pathogen that causes potato late blight. It secretes numerous effector proteins to manipulate host immunity. Understanding mechanisms underlying their host cell manipulation is crucial for developing disease resistance strategies. Here, we report that the conserved RXLR effector Pi05910 of P. infestans is a genotype‐specific avirulence elicitor on potato variety Longshu 12 and contributes virulence by suppressing and destabilizing host glycolate oxidase StGOX4. By performing co‐immunoprecipitation, yeast‐two‐hybrid assays, luciferase complementation imaging, bimolecular fluorescence complementation and isothermal titration calorimetry assays, we identified and confirmed potato StGOX4 as a target of Pi05910. Further analysis revealed that StGOX4 and its homologue NbGOX4 are positive immune regulators against P. infestans, as indicated by infection assays on potato and Nicotiana benthamiana overexpressing StGOX4 and TRV‐NbGOX4 plants. StGOX4‐mediated disease resistance involves enhanced reactive oxygen species accumulation and activated the salicylic acid signalling pathway. Pi05910 binding inhibited enzymatic activity and destabilized StGOX4. Furthermore, mutagenesis analyses indicated that the 25th residue (tyrosine, Y25) of StGOX4 mediates Pi05910 binding and is required for its immune function. Our results revealed that the core RXLR effector of P. infestans Pi05910 suppresses plant immunity by targeting StGOX4, which results in decreased enzymatic activity and protein accumulation, leading to enhanced plant susceptibility.
A case of meningitis caused by Arcobacter butzleri
Authors: Yasuda Tsutomu , Inaba Yuka , Kinugasa Satoshi , Mawatari Momoko , Tanaka Yui , Ogura Kentaro , Tamura Misumi , Sumura Rena , Shirakawa Kana , Horiuchi Emiko , Ishibashi Yoshitaka , Hashida Hideji 
Published: November 2024

AbstractA 73‐year‐old male who was a compromised host developed bacteremia, pyelonephritis, and bacterial meningitis due to Arcobacter butzleri. To the best of our knowledge, this is the first report of meningitis caused by A. butzleri. The outcome of treatment with meropenem was excellent. We speculate that the ingestion of contaminated chicken meat caused bacteremia via the digestive tract, leading to pyelonephritis and meningitis. A. butzleri is a possible cause of bacterial meningitis even in the absence of severe gastrointestinal symptoms.
Binding of PtoRAP2.12 to demethylated and accessible chromatin regions in the PtoGntK promoter stimulates growth of poplar
Authors: He Yuling , Zhou Jiaxuan , Lv Chenfei , Zhang Jinhan , Zhong Leishi , Zhang Donghai , Li Peng , Xiao Liang , Quan Mingyang , Wang Dan , Zhang Deqiang , Du Qingzhang 
Published: November 2024

Summary
DNA methylation is an essential epigenetic modification for gene regulation in plant growth and development. However, the precise mechanisms of DNA methylation remain poorly understood, especially in woody plants.
We employed whole‐genome bisulfite sequencing (WGBS), assays for transposase‐accessible chromatin using sequencing (ATAC‐seq), and RNA‐Seq to investigate epigenetic regulatory relationships in Populus tomentosa treated with DNA methylation inhibitor 5‐azacitidine. Expression‐quantitative trait methylation analysis (eQTM), epigenome‐wide association study (EWAS), and joint linkage‐linkage disequilibrium mapping were used to explore the epigenetic regulatory genes, and using CRISPR/Cas9 to identify the role of candidate genes.
Plant developmental abnormalities occurred when DNA methylation levels were substantially reduced. DNA methylation regulated 112 expressed genes via chromatin accessibility, of which 61 genes were significantly influenced by DNA methylation variation at the population level. One DNA methylation‐regulated gene, PtoGntK, was located in a major quantitative trait locus (QTL) for poplar growth. Overexpression and CRISPR/Cas9 of PtoGntK revealed it affected poplar height and stem diameter. The PtoRAP2.12 was found to bind to the demethylated accessible region in the PtoGntK promoter, thereby promoting growth in poplar.
This study identified key genes with epigenetic regulation for plant growth and provides insights into epigenetic regulation mechanisms in woody plants.
Exploring Older People's Experiences and Factors Associated With 30‐Day Hospital Readmission: A Qualitative Study Using Interpretive Phenomenological Analysis
Authors: Stavrou Fanis , Adams Jo , Patel Harnish P. , Vassilev Ivaylo , Samuel Dinesh 
Published: November 2024

ABSTRACTIntroductionHospital readmission has a negative impact on older people and the healthcare system. Current hospital readmission research predominantly reports on clinical outcomes based on cross‐sectional data. Research exploring patients' experiences and priorities is limited. This study aimed to explore older people's experiences of hospital readmission in order to develop an understanding of what matters most to them.MethodsSemi‐structured qualitative interviews were conducted to generate data that were analysed using principles of interpretative phenomenological analysis.ResultsTen participants over 65 years old, who had experienced unplanned hospital readmission within a period of 30 days, were recruited from a large single tertiary referral centre. Four themes emerged: ‘All about me without me’, ‘Fragmented and ad hoc post‐discharge support’, ‘My readmission experience and what led me back’ and ‘Segregated health and social services that are detached from people's needs’.ConclusionThe study findings suggest that patients should be more involved in decisions about their care, and health professionals should endeavour to better understand the contexts, resources and access to formal and informal support of patients. Effective communication and stronger continuum of care could be a key to patients' recovery and avoidance of hospital readmission. This research highlights the importance of shared decision‐making and patient‐centred care to improve quality of care, maintain independence and preserve older adult's right to feel valued.
Emotion processes in voice‐hearers: Understanding differences in emotional reactivity, emotion regulation and alexithymia
Authors: Cusworth Kelly , Paulik Georgie , Thomas Neil , Preece David , Campitelli Guillermo , Mathersul Danielle C. 
Published: November 2024

AbstractObjectivesDisrupted emotion processes are commonly linked to the onset and maintenance of auditory verbal hallucinations. However, a comprehensive approach using an extended emotion model has not previously been applied to voice‐hearers to distinguish impairments in emotion processes from non‐clinical populations. The present study hypothesised voice‐hearers, as compared to controls, would have (1) higher reactivity to negative emotions and lower reactivity to positive emotions, (2) more difficulties regulating negative and positive emotions, (3) more maladaptive strategy use, and (4) higher alexithymia.MethodT‐tests tested these hypotheses, comparing self‐report measures of emotional reactivity, emotion regulation and alexithymia in voice‐hearers (n = 50) to controls (n = 53).ResultsThere were no group differences in emotional reactivity to positive or negative emotions. Compared to controls, voice‐hearers showed difficulties in both positive and negative emotion regulation, were more likely to use expressive suppression, and were more likely to be alexithymic.ConclusionsThese findings may help researchers and clinicians identify difficulties in voice‐hearers' emotion processing, providing better direction for case formulation and treatment.
Beyond regulatory capture: Policy entrepreneurs' strategies in regulatory policies under authoritarianism
Authors: El Haddad Ahmed Fouad 
Published: November 2024

AbstractThis article examines the role of policy entrepreneurs in countering regulatory capture, a phenomenon whereby regulatory bodies influenced by industry lobbying often prioritize private over public interests. The study employs an abductive process‐tracing approach to investigate the 2013 drug pricing reform in Morocco, illustrating how substantial policy shifts can occur even in authoritarian contexts susceptible to regulatory capture. The findings underscore the pivotal role of Houcine El Ouardi, the former Minister of Health, whose strategic leadership exemplified policy entrepreneurship. His capacity to navigate and surmount industry resistance was instrumental to the reform's success, culminating in a significant reduction in drug prices. This case challenges conventional wisdom regarding regulatory capture, demonstrating that individual agency can reshape regulatory outcomes despite opposition. By elucidating how policy entrepreneurs can drive transformative change in resistant regulatory environments under authoritarian regimes, the study contributes to the literature on policy entrepreneurship and regulation.
F‐Box and WD repeat domain containing 7 induces infectious osteomyelitis by regulating MYB stability and ubiquitination
Authors: Wan Yongbo , Jiang Gehan , Shan Haojie , Lin Yiwei , Xia Wenyang , Yin Fuli , Jiang Chaolai , Shi Zhongmin 
Published: November 2024

AbstractOsteomyelitis is a bone inflammation initiated by invading pathogens. Macrophages and inflammation play essential roles in osteomyelitis. F‐Box and WD repeat domain containing 7 (Fbxw7) is a tumour suppressor and E3 ubiquitin ligase. In the present study, the potential roles of Fbxw7 in osteomyelitis were explored. The mRNA level of Fbxw7 was measured in bone marrow cells from patients with osteomyelitis and Staphylococcus aureus (S. aureus)‐infected macrophages. The conditional knockout mice with Fbxw7 deficiency in myeloid cells were generated. The expression of interleukin (IL)‐6, IL‐23a and nitric oxide synthase 2 (Nos2) was measured in S. aureus‐infected Fbxw7‐deficient bone marrow‐derived macrophages (BMDMs). The body weight loss, bacterial burden, bone loss and formation and serum level of IL‐6, IL‐23 and TNF‐α were measured in S. aureus‐infected Fbxw7 conditional KO mice. The interacting partners of Fbxw7 were predicted using STRING and the interaction were tested. Elevated expression of Fbxw7 was observed in bone marrow cells from patients with osteomyelitis and in S. aureus‐infected macrophages. The expression of IL‐6, IL‐23a and Nos2 was remarkably suppressed in S. aureus‐infected Fbxw7‐deficient BMDMs. Fbxw7 conditional knockout mice had less body weight loss, higher bacterial burden, less bone loss and formation and decreased serum level of cytokines. Fbxw7 interacted with MYB. S. aureus‐infected Fbxw7‐deficient BMDMs had higher level of MYB and less ubiquitination of MYB. Fbxw7 promotes osteomyelitis symptoms by regulating ubiquitination and stability of MYB.
Adropin regulates macrophage phenotype via PPARγ signalling: A preliminary study of adropin and Crohn's disease
Authors: Zeng Lingli , Chen Jintong , Xie Hongchai , Liu Wenming , Wang Chengdang 
Published: November 2024

AbstractMacrophage polarization is increasingly recognized as a vital pathogenetic factor in Crohn's disease (CD). Adropin is a secreted protein implicated in energy homeostasis, chiefly linked to glucose and lipid metabolism. However, the significance of adropin in CD is not clear. The objective of this study was to detect the expression of adropin in CD patients and investigate the effect of adropin on macrophage polarization induced by lipopolysaccharide (LPS) and its potential mechanism. Our study showed that serum adropin levels were markedly lower in patients with CD in active (CDA) than patients with CD in remission (CDR) and control groups (p < 0.01), however, there was no significant difference between in remission CD and healthy controls (p > 0.05). The colon mucous adropin levels in CDA were distinctly higher than CDR and controls (p < 0.01), while a significant difference between in remission CD and in healthy controls was not observed (p > 0.05). Exploration of the specific mechanism of action indicated that adropin promoted LPS‐induced RAW264.7 macrophage polarization to M2 phenotype by modulating the expression and nuclear translocation of peroxisome proliferator receptor gamma (PPARγ), which may help weaken the intestinal inflammatory response. PPARγ inhibitor GW9662 reversed adropin‐induced M2 macrophage polarization. Knockdown of GPR19, an adropin receptor, abrogated the M2 macrophage polarization caused by PPARγ. These findings suggest that adropin in colonic mucosa is a protective response in patients with active Crohn's disease.
Lithospheric Deformation of Far‐Field Terranes in Response to the India–Asia Collision
Authors: Luo Yun , Yang Jianfeng , Zhao Liang , Zhao Pan 
Published: November 2024

ABSTRACTThe influence of the India–Asia collision is far‐reaching on the Cenozoic continental deformation in East Asia. Several cratonic lithospheres surrounding Tibet exhibit distinct lithospheric morphologies. However, the mechanisms driving these diverse responses of strong terranes remain incompletely understood. Here, we conduct thermo‐mechanical models to explore the effects of the width of the mobile belts, lithospheric properties and convergence rate on the deformation of the strong terranes. The model results reveal three different deformation modes. Far‐field strong terranes are vulnerable to delamination or underthrusting when the mobile belt is narrow and detached, whereas they remain largely undeformed when it is wide and strong. These deformation patterns align with the observed lithospheric structures around the Tibetan Plateau and are primarily influenced by the convergence rate and proximity to the collision front. Our findings provide new insights into the lithospheric deformation mechanisms of cratonic terranes in response to continental collision.
Diurnal control of H3K27me1 deposition shapes expression of a subset of cell cycle and DNA damage response genes
Authors: Fung‐Uceda Jorge , Gómez María Sol , Rodríguez‐Casillas Laura , González‐Gil Anna , Gutierrez Crisanto 
Published: November 2024

SUMMARYRhythmic oscillation of biological processes helps organisms adapt their physiological responses to the most appropriate time of the day. Chromatin remodeling has been described as one of the molecular mechanisms controlling these oscillations. The importance of these changes in transcriptional activation as well as in the maintenance of heterochromatic regions has been widely demonstrated. However, little is still known on how diurnal changes can impact the global status of chromatin modifications and, hence, control gene expression. In plants, the repressive mark H3K27me1, deposited by ARABIDOPSIS TRITHORAX‐RELATED PROTEIN 5 and 6 (ATXR5 and 6) methyltransferases, is largely associated with transposable elements but also covers lowly expressed genes. Here we show that this histone modification is preferentially deposited during the night. In euchromatic regions, it is found along the bodies of DNA damage response genes (DDR), where it is needed for their proper expression. The absence of H3K27me1 translates into an enhanced expression of DDR genes that follows a rhythmic oscillation pattern. This evidences a link between chromatin modifications and their synchronization with the diurnal cycle in order to accurately modulate the activation of biological processes to the most appropriate time of the day.
Continuity of the j$j$‐function on the Markov tree
Authors: Bengoechea Paloma 
Published: November 2024

AbstractOne way of defining the values of the modular ‐function at real quadratic irrationalities is by its cycle integrals along geodesics in the upper half plane whose endpoints are the roots of an indefinite binary quadratic form. We show that the restriction of the modular ‐function to Markov irrationalities (an important subset of real quadratic irrationalities in diophantine approximation) is continuous with respect to the topology induced by the euclidean norm.
On the topology of determinantal links
Authors: Zach Matthias 
Published: November 2024

AbstractWe study sections of the generic determinantal varieties by generic hyperplanes of various codimensions , the polar multiplicities of these sections, and the cohomology of their real and complex links. Such complex links were shown to provide the basic building blocks in a bouquet decomposition for the (determinantal) smoothings of smoothable isolated determinantal singularities. The detailed vanishing topology of such singularities was still not fully understood beyond isolated complete intersections and a few further special cases. Our results now allow to compute all the cohomology with integer coefficients below the middle degree and the middle Betti number for any determinantal smoothing.
Continuity of extensions of Lipschitz maps and of monotone maps
Authors: Ciosmak Krzysztof J. 
Published: November 2024

AbstractLet be a subset of a Hilbert space. We prove that if is such that
for all and all non‐negative that add up to one, then for any 1‐Lipschitz , with , there exists a 1‐Lipschitz extension of such that the uniform distance on between and is the same as the uniform distance on between and .Moreover, if either or is convex, we prove the converse: We show that a map that allows for a 1‐Lipschitz, uniform distance preserving extension of any 1‐Lipschitz map on a subset of also satisfies the above set of inequalities. We also prove a similar continuity result concerning extensions of monotone maps. Our results hold true also for maps taking values in infinite‐dimensional spaces.