bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitrocommunity synergy between bacterial soil isolates can be facilitated by pH stabilisation of the environment
Authors: Herschend Jakob , Koren Klaus , Røder Henriette L. , Brejnrod Asker , Kühl Michael , Burmølle Mette 
Published: June 2018

AbstractComposition and development of naturally occurring microbial communities is defined by a complex interplay between the community and the surrounding environment and by interactions between community members. Intriguingly, these interactions can in some cases cause community synergies where the community is able to outperform it single species constituents. However, the underlying mechanisms driving community interactions are often unknown and difficult to identify due to high community complexity. Here we show how pH stabilisation of the environment through the metabolic activity of specific community members acts as a positive inter-species interaction drivingin vitrocommunity synergy in a model consortium of four co-isolated soil bacteria:Microbacterium oxydans,Xanthomonas retroflexus,Stenotrophomonas rhizophilaandPaenibacillus amylolyticus. Using micro-sensor pH measurements to show how individual species change the local pH micro-environment, and how co-cultivation leads to a stabilised pH regime over time. Specifically,in vitroacid production fromPaenibacillus amylolyticusand alkali production primarily fromXanthomonas retroflexuslead to an overall pH stabilisation of the local environment over time, which in turn resulted in enhanced community growth. This specific type of interspecies interaction was found to be highly dependent on media type and media concentration, however similar pH drift from the individual species could be observed across media variants.ImportanceWe show thatin vitrometabolic activity of individual members of a synthetic, co- isolated model community presenting community synergistic growth arises through the inter-species interaction of pH stabilization of the community micro-environment. The observed inter-species interaction is highly media specific and most pronounced under high nutrient availability. This adds to the growing diversity of identified community interactions leading to enhanced community growth.
Impact of Sexual Transmission to Sex-specific Attack Rates in Zika Epidemics
Authors: de Barros Ana Carolina W.G. , Santos Kaline G. , Massad Eduardo , Coelho Flávio Codeço 
Published: June 2018

ABSTRACTIn 2015 and 2016 South America went through the largest Zika epidemic in recorded history. One important aspect of this epidemic was the impact on newborns due to the effect of Zika on development of the central nervous system leading to severe malformations. Another aspect of the Zika epidemic which became evident from the data was the importance of the sexual route of transmission leading to increased risk for women. Here propose a mathematical model for the transmission of the Zika virus including sexual transmission via all forms of sexual contact, as well as simplified vector transmission, assuming a constant availability of mosquitoes. From this model we derive an expression forℛ0which can be used to study and analyze the relative contributions of the different routes of Zika transmission and the male to female sexual transmission route vis-a-vis vectorial transmission. We also fit the model to data from the 2016 Zika epidemic in Rio de Janeiro, to estimate the values of key parameters of the model.
Attitudes, Perceptions and Barriers to Research and Publishing among Research and Teaching Staff: A Case Study
Authors: Okoduwa Stanley I.R. , Abe James O. , Samuel Blessing I. , Chris Aimee O. , Oladimeji Richard A. , Idowu Olanipekun O. , Okoduwa Ugochi J. 
Published: June 2018

AbstractBackgroundThe economic development of any nation is centered on research. Unfortunately, research activities had suffered serious setback in tertiary research institutions in Nigeria. This study explores the attitudes, perceptions and barriers to research and publishing among academic staff in Nigerian Institute of Leather and Science Technology, (NILEST) Zaria Nigeria.MethodA structured self-administered questionnaire was distributed among 130 research and teaching staff at the various Directorates in NILEST. Data are presented in frequencies and percentages for questionnaire responses.ResultExactly 93.85%of the questionnaires were validated for the study which included 81.15% male and 18.85% female. The participant were researchers (26.23%), lecturers (31.15%), Technologist (20.49%) and Instructors (22.13%). The majority of participant agreed that research is important for the institute (90.98%). A total of 81.15% believed that conducting research should be mandatory for all academic staff. Only 44.26% was self-reported to have ongoing research. Some of the obstacles reported to have prevented research activities included: lack of funding (72.13%), lack of professional mentorship (84.43%) and inadequate research facilities (89.34%). Participants without a single published paper were 54.545%. Some of the reasons given for not having published papers were “no writing experience (95.65%), high publishing fee (79.71%) and long waiting period for peer review (97.10%)”. The suggestions to improve research status by respondents included“ provision of research grants/funds (92.62%), provision of internet facilities (95.10%), mandatory publication (26.23%) and appropriate mentorship (34.43%).ConclusionMajority of the respondents believed that research is relevant, only a few were engaged in active research and published articles as evidence. It is therefore recommended that policy makers should devise strategies to focus on active research activities in order to achieve the desire research mandate and goal of institutions in the development of the nation’s economy.
Spike burst–pause dynamics of Purkinje cells regulate sensorimotor adaptation
Authors: Luque Niceto R. , Naveros Francisco , Carrillo Richard R. , Ros Eduardo , Arleo Angelo 
Published: June 2018

AbstractCerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses. Here, a spiking cerebellar model assesses the role of Purkinje cell firing patterns in vestibular ocular reflex (VOR) adaptation. The model captures the cerebellar microcircuit properties and it incorporates spike-based synaptic plasticity at multiple cerebellar sites. A detailed Purkinje cell model reproduces the three spike-firing patterns that are shown to regulate the cerebellar output. Our results suggest that pauses following Purkinje complex spikes (bursts) encode transient disinhibition of targeted medial vestibular nuclei, critically gating the vestibular signals conveyed by mossy fibres. This gating mechanism accounts for early and coarse VOR acquisition, prior to the late reflex consolidation. In addition, properly timed and sized Purkinje cell bursts allow the ratio between long-term depression and potentiation (LTD/LTP) to be finely shaped at mossy fibre-medial vestibular nuclei synapses, which optimises VOR consolidation. Tonic Purkinje cell firing maintains the consolidated VOR through time. Importantly, pauses are crucial to facilitate VOR phase-reversal learning, by reshaping previously learnt synaptic weight distributions. Altogether, these results predict that Purkinje spike burst-pause dynamics are instrumental to VOR learning and reversal adaptation.Author SummaryCerebellar Purkinje cells regulate accurate eye movement coordination. However, it remains unclear how cerebellar-dependent oculomotor adaptation depends on the interplay between Purkinje cell characteristic response patterns: tonic, high-frequency bursting, and post-complex spike pauses. We explore the role of Purkinje spike burst-pause dynamics in VOR adaptation. A biophysical model of Purkinje cell is at the core of a spiking network model, which captures the cerebellar microcircuit properties and incorporates spike-based synaptic plasticity mechanisms at different cerebellar sites. We show that Purkinje spike burst-pause dynamics are critical for (1) gating the vestibular-motor response association during VOR acquisition; (2) mediating the LTD/LTP balance for VOR consolidation; (3) reshaping synaptic efficacy distributions for VOR phase-reversal adaptation; (4) explaining the reversal VOR gain discontinuities during sleeping.
Representational structure or task structure? Bias in neural representational similarity analysis and a Bayesian method for reducing bias
Authors: Cai Ming Bo , Schuck Nicolas W. , Pillow Jonathan W. , Niv Yael 
Published: June 2018

AbstractThe activity of neural populations in the brains of humans and animals can exhibit vastly different spatial patterns when faced with different tasks or environmental stimuli. The degree of similarity between these neural activity patterns in response to different events is used to characterize the representational structure of cognitive states in a neural population. The dominant methods of investigating this similarity structure first estimate neural activity patterns from noisy neural imaging data using linear regression, and then examine the similarity between the estimated patterns. Here, we show that this approach introduces spurious bias structure in the resulting similarity matrix, in particular when applied to fMRI data. This problem is especially severe when the signal-to-noise ratio is low and in cases where experimental conditions cannot be fully randomized in a task. We propose Bayesian Representational Similarity Analysis (BRSA), an alternative method for computing representational similarity, in which we treat the covariance structure of neural activity patterns as a hyper-parameter in a generative model of the neural data. By marginalizing over the unknown activity patterns, we can directly estimate this covariance structure from imaging data. This method offers significant reductions in bias and allows estimation of neural representational similarity with previously unattained levels of precision at low signal-to-noise ratio. The probabilistic framework allows for jointly analyzing data from a group of participants. The method can also simultaneously estimate a signal-to-noise ratio map that shows where the learned representational structure is supported more strongly. Both this map and the learned covariance matrix can be used as a structured prior for maximuma posterioriestimation of neural activity patterns, which can be further used for fMRI decoding. We make our tool freely available in Brain Imaging Analysis Kit (BrainIAK).Author summaryWe show the severity of the bias introduced when performing representational similarity analysis (RSA) based on neural activity pattern estimated within imaging runs. Our Bayesian RSA method significantly reduces the bias and can learn a shared representational structure across multiple participants. We also demonstrate its extension as a new multi-class decoding tool.
Heterozygote Advantage Can Explain the Extraordinary Diversity of Immune Genes
Authors: Siljestam Mattias , Rueffler Claus 
Published: June 2018

AbstractThe majority of highly polymorphic genes are related to immune functions and with over 100 alleles within a population, genes of the major histocompatibility complex (MHC) are the most polymorphic loci in vertebrates. How such extraordinary polymorphism arose and is maintained is controversial. One possibility is heterozygote advantage (HA), which can in principle maintain any number of alleles, but biologically explicit models based on this mechanism have so far failed to reliably predict the coexistence of significantly more than ten alleles. We here present an eco-evolutionary model showing that evolution can result in the emergence and maintenance of more than 100 alleles under HA if the following two assumptions are fulfilled: first, pathogens are lethal in the absence of an appropriate immune defence; second, the effect of pathogens depends on host condition, with hosts in poorer condition being affected more strongly. Thus, our results show that HA can be a more potent force in explaining the extraordinary polymorphism found at MHC loci than currently recognized.
Biological motion as an innate perceptual mechanism driving social affiliation
Authors: Larsch Johannes , Baier Herwig 
Published: June 2018

AbstractCollective behavior, such as shoaling in teleost fish, is driven by the perceptual recognition of conspecific animals. Because social interactions are mutual, it has been difficult to disentangle the exact sensory cues that trigger affiliation in the first place from those that are emitted by receptive and responsive shoal mates. Here we overcome this challenge in a virtual reality assay in zebrafish. We discovered that simple visual features of conspecific biological motion provide an irresistible shoaling cue. Individual juvenile fish interact with circular black dots projected onto a screen, to the same extent as they do with real conspecifics, provided these virtual objects mimic the characteristic kinetics of zebrafish swim bouts. Other naturalistic cues previously implicated in shoaling, such as fish-like shape, pigmentation pattern, or non-visual sensory modalities are not required. During growth, the animals’ stimulus preferences shift gradually, matching self-like kinetics, even in fish raised in isolation. Virtual group interactions and our multi-agent model implementation of this perceptual mechanism demonstrate sufficiency of kinetic cues to drive assortative shoaling, a phenomenon commonly observed in field studies. Coordinated behavior can emerge from autonomous interactions, such as collective odor avoidance inDrosophila, or from reciprocal interactions, such as the codified turn-taking in wren duet singing. We found that individual zebrafish shoal autonomously without evidence for a reciprocal choreography. Our results reveal individual-level, innate perceptual rules of engagement in mutual affiliation and provide experimental access to the neural mechanisms of social recognition. (239/250 words max)Significance StatementSocial affiliation is ubiquitous in the animal kingdom, but fundamental sensory cues driving group formation remain elusive. During swarm behavior, for example, individuals dynamically exchange sensory cues with their neighbors, presenting an intertwined choreography opaque to formal analysis of causal stimulus-response relationships. Using a virtual interaction assay for psychophysical analysis, we solved this issue and identify biological motion as the irresistible trigger of social affiliation in zebrafish,Danio rerio. Given that many species form groups including shoals, flocks and herds, perceptual mechanisms of social recognition and their underlying neural circuits are likely shared across vertebrates. The identification of fundamental affiliation-inducing cues is a prerequisite for relating individual-level sensory-motor transformations to collective behavior. (112/120 words max)
G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
Authors: Wang Yuxiang , Yang Jie , Wu Wei , Shah Rachna , Danussi Carla , Riggins Gregory J. , Kannan Kasthuri , Sulman Erik P. , Chan Timothy A. , Huse Jason T. 
Published: June 2018

AbstractMutational inactivation ofATRX(α-thalassemia mental retardation X-linked) represents a defining molecular alteration in large subsets of malignant glioma. Yet the pathogenic consequences of ATRX deficiency remain unclear, as do tractable mechanisms for its therapeutic targeting. Here we report that ATRX loss in isogenic glioma model systems induces replication stress and DNA damage by way of G-quadruplex (G4) DNA secondary structure. Moreover, these effects are associated with the acquisition of disease-relevant copy number alterations over time. We then demonstrate, bothin vitroandin vivo, that ATRX deficiency selectively enhances DNA damage and cell death following chemical G4 stabilization. Finally, we show that G4 stabilization synergizes with other DNA-damaging therapies, including ionizing radiation, in the ATRX-deficient context. Our findings reveal novel pathogenic mechanisms driven by ATRX deficiency in glioma, while also pointing to tangible strategies for drug development.
From one-sized to over-individualized? Service logic’s value creation
Authors: Eriksson Erik Masao , Nordgren Lars 
Published: June 2018

PurposeThere is a current trend in healthcare management away from produced and standardized one-size-fits-all processes toward co-created and individualized services. The purpose of this paper is to increase understanding of the value concept in healthcare organization and management by recognizing different levels of value (private, group and public) and the interconnectedness among these levels.Design/methodology/approachThe paper uses social constructionism as a lens to problematize the individualization of service logic’s value concept. Theories from consumer culture theory/transformative service research and public management add group and public levels of value to the private level.FindingsAn intersubjective (rather than subjective) approach to value creation entails the construction and sharing of value perceptions among groups of people. Such an approach also implies that group members may face similar barriers in their value creation efforts.Practical implicationsHealthcare management should be aware of the inherent individualism of service logic and, consequently, the need to balance private value with group and public levels of value.Social implicationsIdentifying and addressing disadvantaged groups and the reasons for their disadvantaged positions is important in order to enhance the individual’s value creation prerequisites as well as to address public and societal values, such as equal/equitable health(care).Originality/valueIt is important to complement service logic’s value creation with group and public levels in order to understand the complexity and interconnectedness of value and the creation thereof.
The health care home in New Zealand: rolling out a new model of primary health care
Authors: Cumming Jacqueline , Dunn Phoebe , Middleton Lesley , O’Loughlin Claire 
Published: June 2018

Purpose
The purpose of this paper is to report on the origins, development and early impacts of a Health Care Home (HCH) model of care being rolled out around New Zealand (NZ).

Design/methodology/approach
This paper draws on a literature review on HCHs and related developments in primary health care, background discussions with key players, and a review of significant HCH implementation documents.

Findings
The HCH model of care is emerging from the sector itself and is being tailored to local needs and to meet the needs of local practices. A key focus in NZ seems to be on business efficiency and ensuring sustainability of general practice – with the assumption that freeing up general practitioner time for complex patients will mean better care for those populations. HCH models of care differ around the world and NZ needs its own evidence to show the model’s effectiveness in achieving its goals.

Research limitations/implications
It is still early days for the HCH model of care in NZ and the findings in this paper are based on limited evidence. Further evidence is needed to identify the model’s full impact over the next few years.

Originality/value
This paper is one of the first to explore the HCH model of care in NZ.
Driving forces and structural changes of China as a market provider for Korea
Authors: Feng Yongqi , Zhang Tianshu 
Published: June 2018

Purpose
The purpose of this paper is to provide a better understanding of the driving forces and structural changes of China as a market provider for Korea. This paper gives the answers for the following questions: How do China’s final demands trigger the growth of its imports from Korea? And what’s the impact of China’s final demands on the import in different industries?

Design/methodology/approach
Based on the Multi-Regional Input-Output model and World Input-Output Table database, this paper constructs the non-competitive imports input-output (IO) table of China to Korea. According to this table, we can calculate the induced imports coefficient and comprehensive induced import coefficients of China’s four final demands for imports from Korea in the 56 industries in China.

Findings
Among the four driving forces, the strongest one is changes in inventories and valuables. The impact of final consumption expenditure and fixed capital formation is much lower than that of changes in inventories and valuables, but they have a broader impact for the 56 industries. This paper finds out the China’s import induction of the final demands to Korea peaked in 2005 and 2010 and decreased greatly in 2014, so the position of China as market provider for Korea will no longer rise substantially, contrarily it will be in a steady state.

Originality/value
First, this paper constructs the non-competitive IO table to analyze the market provider issues between two countries and provides practical ways and methods for studies on the issues of imports and market provider. Second, this paper investigates the different roles of four final demands on driving force of China as market provider for Korea and the structural changes of China as a market provider for Korea among 56 industries from 2000 to 2014.
The effects of Paris agreements on Korean economy and trade analyzed by the computational general equilibrium method considering firm’s heterogeneity
Authors: Roh Jae-whak , Kim Hyunjae 
Published: June 2018

Purpose
During the Paris Convention, Korean Government made commitment to curb carbon emission by 37 percent by the year of 2030. Since then there has been constant debate, both in media and academia, as to whether attempts to reduce carbon emission would spell the concomitant economic slowdown. The purpose of this paper is to build a Computable General Equilibrium (CGE) model to see the effects of emission decrease on Korea economy.

Design/methodology/approach
To answer the above question, we build a comprehensive framework to gauge the economic impact of Paris Convention through the lens of Computable General Equilibrium (CGE) model using Armington and Melitz model.

Findings
Contrary to conventional wisdom, Korea’s economic performance in terms of welfare remains robust when the carbon emission is reduced. Broadly speaking, Korea’s welfare does not contract significantly in part due to expansion at the export market. For instance, the energy intensive industry (EIT) is affected most directly from the Paris Convention commitment and yet it experiences growth in export. On the contrary, the authors find that the general economic impact on Korea’s output is negative. The additional experiment using Melitz model shows that as the carbon reduction is enforced, both the number and the average productivity of the exporting firms increase in the EIT sector, which the authors refer in the paper as the “Melitz Effect.”

Practical implications
This paper shows that what can be occurred in Korean industries by emission decrease commitment.

Social implications
One byproduct from restricting carbon emission is the surge in the electricity price. This is due to the fact that industries have to shift away from traditional fuels such as oil to electricity for energy. Therefore the authors propose that industrial policies aimed at balancing electricity price should accompany the plan to reduce carbon emission.

Originality/value
For Korean economy, the effects of emission reduction is researched using Armington and Melitz model at the same time. Especially, this is the first research case using the Melitz model in this Korean topic.