bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rheology and Culture Reproducibility of Filamentous Microorganisms: Impact of Flow Behavior and Oxygen Transfer During Salt‐Enhanced Cultivation of the Actinomycete Actinomadura namibiensis
Authors: Hanke René , Lohr Jonas , Poduschnick Leon , Tesche Sebastian , Fillaudeau Luc , Büchs Jochen , Krull Rainer 
Published: November 2024

ABSTRACTAnalyzing the relationship between cell morphology, rheological characteristics, and production dynamics of cultivations with filamentous microorganisms is a challenging task. The complex interdependencies and the commonly low reproducibility of heterogeneous cultivations hinder the bioprocess development of commercially relevant production systems. The present study aims to characterize process parameters in Actinomadura namibiensis shake flask cultures to gain insights into relationships between culture behavior and rheological characteristics during salt‐enhanced labyrinthopeptin A1 production. Plate–plate (PP) and vane–cup rheometer measurements of viscous model fluids and culture broths are compared, revealing a more uniform distribution of broth when measured with the PP system. Additionally, rheological characteristics and culture performance of A. namibiensis cultures are evaluated using online data of the specific power input and the oxygen transfer rate. It is demonstrated that salt‐enhancement labyrinthopeptin A1 production by the addition of 50 mM (NH4)2SO4 increases the apparent viscosity of the A. namibiensis culture by four‐fold and significantly reduces the reproducibility of the culture resulting in a 46 h difference in lag‐phase duration. This approach demonstrates that the culture behavior of complex filamentous cell morphologies is challenging to decipher, but online monitoring of rheology and oxygen transfer can provide valuable insights into the cultivation dynamics of filamentous microbial cultures.
High‐Performance SMA–Based Self‐Centring Precast Segmental Concrete Column: Design Concept, Test and Simulation
Authors: Chen Zhi‐Peng , Zhang Lu , Huang Jiahao , Zhu Songye 
Published: November 2024

ABSTRACTThis paper presents an experimental study of a novel high‐performance self‐centring (SC) precast segmental concrete column (PSCC) utilising shape memory alloy (SMA) bolts. The tested PSCC was constructed with four precast concrete segments and had a total height of 1555 mm. The whole column was assembled by connecting four segments through bolts solely, without using any complex anchorage for posttensioned components. Four 20‐mm‐diameter SMA bolts were used at the column base, whilst other segments were connected using high‐strength steel bolts. Certain levels of prestrain were applied in the SMA and steel bolts when assembling, causing some minor initial cracks around the segment corners due to the casting imperfection and small gaps between the segments; however, no further crack development was observed after achieving stability. A series of cyclic and monotonic quasi‐static tests were conducted to examine the working mechanism, structural behaviour, reusability, ductility and failure mode. Two cyclic horizontal loadings corresponding to a maximum drift ratio of 5% were applied consecutively, wherein the SMA bolts were retightened by hand in between. The SMA‐SC‐PSCC showed desirable flag‐shaped behaviour under both loadings, with only some minor damages found on the concrete segments. Then, a monotonic loading was applied until the failure of the specimen, and the bottom segment fractured at a displacement of 86 mm (corresponding to 5.8% drift ratio). After the tests, a refined finite element model simulation was conducted as complementation. The satisfactory performance of the SC‐PSCC showed that by using SMA bolts, the high‐performance, low‐damage and easy‐construction design can be achieved simultaneously. The experimental and numerical results provided a promising design alternative in modern earthquake‐resilient civil infrastructure.
Comparing the coagulation and platelet parameters of women with premature ovarian insufficiency with those of age‐matched controls: A case–control study
Authors: Lou Zheng , Huang Yizhou , Xu Hongyan , Cen Xiaoping , Zhang Yue , Xu Yan , Luo Zhou , Li Chunming , Chen Caiwei , Shi Shuyi , Su Chang , Lin Xi , Ma Linjuan , Zhou Jianhong 
Published: November 2024

AbstractObjectiveThis study aimed to compare the coagulation and platelet parameters in women with spontaneous premature ovarian insufficiency (POI) with those in age‐matched controls.MethodsThis case–control study recruited 202 women with POI and 202 age‐matched women with benign gynecological diseases as controls. Coagulation parameters, including prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), and thrombin time (TT), fibrinogen, and platelet parameters, including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW), were compared between women with POI and controls. Factors associated with coagulation and platelet parameters were also analyzed in women with POI.ResultsIn women with POI, higher fibrinogen levels and PDW, lower PLT, MPV, and PCT levels, and shorter TT were observed (p < 0.001). Linear regression analysis further revealed that women with POI were more likely to exhibit increased serum fibrinogen levels (β = 0.465, 95% confidence interval [CI] 0.366–0.564) and PDW (β = 0.340, 95% CI 0.300–0.379), decreased TT (β = −1.101, 95% CI –1.233–−0.969), PLT (β = −50.985, 95% CI –65.087–−36.882), MPV (β = −1.498, 95% CI –1.875 to −1.120), PCT levels (β = −0.084, 95% CI –0.095–−0.973). Additionally, follicle‐stimulating hormone levels were positively associated with fibrinogen levels in women with POI. There were no statistically significant differences in PT, INR, and APTT between women with POI and controls.ConclusionsWomen with POI exhibited decreased platelet numbers, abnormal platelet morphology, and elevated fibrinogen concentrations, potentially implicating POI's etiopathogenesis or contributing to an increased risk of cardiovascular disease in women with POI. No coagulation abnormalities were observed in women with POI.
An overview of Hospital‐at‐home versus other models of care
Authors: Wong Hai Liang Marc , Ong Chong Yau , Ngo Hui Juan , Yeo Si Sen , Lee Mui Hua Jean 
Published: November 2024

AbstractDespite being increasingly adopted in various regions, the model of Hospital‐at‐home can still appear to be confusing to many healthcare workers. The authors examined and summarized the existing concepts and implementations of Hospital‐at‐home. How Hospital‐at‐home contrasts to traditional inpatient models were outlined.
Association between early enteral nutrition and length of stay in neonates with congenital bowel obstruction: A retrospective cohort study
Authors: Bhatia Manisha B. , Nelanuthala Sai , Joplin Tasha Sparks , Anderson Cassandra , Sobolic Michael , Gray Brian W. 
Published: November 2024

AbstractBackgroundThe optimal feeding strategy for postoperative neonatal patients with congenital bowel obstruction is widely debated. This study aims to evaluate perioperative characteristics and postoperative nutrition practices for patients with congenital bowel obstruction. We hypothesized that earlier introduction of enteral nutrition (EN) is associated with shorter hospital stays and increased weight gain velocities.MethodsWe performed a retrospective cohort study on neonatal patients (<30 days old) admitted to a pediatric referral hospital who underwent an operation for bowel obstruction between 2010 and 2020. Demographic information, clinical characteristics, and feeding characteristics were collected. Associations between early EN (EEN), defined as commencement of enteral feeding within 5 days of surgery, and perioperative characteristics were analyzed with SAS 9.4.ResultsOf the 97 neonates with congenital bowel obstruction, 36 patients received EEN. Sex, gestational age, and ethnicity were similar between groups. Patients receiving EEN were more likely to have a diagnosis of malrotation, anorectal malformation, or annular pancreas (P = 0.04). Patients receiving EEN weaned from parenteral nutrition earlier (9 vs 17 days, P = 0.005). Receiving EEN was associated with shorter median hospital stay (16 vs 29 days, P < 0.0001). Weight gain velocities at the 2‐month follow‐up were greater for patients receiving EEN (8.02 vs 7.00 g/kg/day, P = 0.04) with the difference dissipating at 6 months.ConclusionEEN was more likely provided in patients with certain operative diagnoses and was associated with improved outcomes. Creating and implementing an EEN protocol in congenitally obstructed neonates may lead to shorter hospital stays and improved outcomes.
RF‐induced heating reduction by minimizing the external portion of the partially in and partially out medical devices under MRI at 1.5 T
Authors: Islam Md Zahidul , Guo Ran , Akter Mir Khadiza , Zheng Jianfeng , Kainz Wolfgang , Long Stuart , Chen Ji 
Published: November 2024

AbstractPurposeTo address the issue of RF‐induced heating for partially in and partially out (PIPO) medical devices during 1.5 T MRI scans by proposing a method of minimizing the external portion.MethodsA method of tightly winding the external segment of the PIPO device is proposed to minimize the overall device effective reception length during MRI scans to mitigate the RF‐induced heating. Two commercially available PIPO medical devices and simplified solid wires were used to demonstrate the concept. RF heating results are compared between typical and minimized‐length trajectories under the American Society for Testing and Materials (ASTM) testing procedure. In addition, 16 scaled and validated device models were used in conjuncture with human body numerical simulations within three virtual human models to estimate clinically relevant heating.ResultsThe wound segments in PIPO devices functioned as a lumped element rather than a receiving antenna, reducing induced energy/heating as compared to the original PIPO devices under typical straight or loop configurations. Minimizing the lead's external portion can reduce the RF‐induced heating by significant factors for all studied cases during ASTM phantom measurements and in human body simulations.ConclusionOur findings show a significant reduction in RF heating by minimizing the external segment, thereby enhancing patient safety during 1.5 T MRI procedures. Although limited to four devices at 1.5 T across two applications, the extent of heating reduction may vary for others. Nonetheless, tightly winding the external segment of PIPO electrodes holds promise for improving device safety under MRI.
Primary malignant melanoma of the breast: A case report without relapse
Authors: Caballero Alejandro , Perez Mario , Rodriguez Issis 
Published: November 2024

AbstractObjectiveThis study aimed to report the treatment and outcomes of a patient with primary malignant melanoma of the breast parenchyma using mastectomy as the main treatment.Patient and methodsA 67‐year‐old female presented with a palpable lump approximately 2 cm in diameter in the lower inner quadrant of the left breast, and underwent ultrasound guided cutting needle biopsy. Cytological examination identified a malignant melanoma of the breast, and she received treatment with a modified radical mastectomy. Further assessment was carried out using a positron emission tomography/computed tomography, which negated the presence of a primary lesion in either adjacent or distant sites.ResultsAfter three years of follow‐up with ultrasonography (USG) and mammography annually and a complete physical examination every six months in the clinic, the patient remained alive with no evidence of local or distant recurrence.ConclusionThe surgical management of this case is appropriate according to the available literature up to the present. We recommend BRAF mutation testing and melanocytic marker testing for all patients to ensure the correct focus when selecting biomarker‐based immunotherapy.
Investigation of Bituminized Waste Products Swelling Behavior Due to Water Uptake Under Confined Leaching Conditions: Experiments and Modeling
Authors: Chen Yujiong , Champenois Jean‐Baptiste , Dangla Patrick , Granet Sylvie , Lautru Joseph , Leclerc Arnaud , Melot Geoffroy 
Published: November 2024

ABSTRACTBituminized waste products (BWPs) were produced by conditioning in bitumen the co‐precipitation sludge resulting from the industrial reprocessing of nuclear spent fuel. For some intermediate level long‐lived (ILW‐LL) classified BWPs, a long‐term disposal solution in France is underground geological disposal. One of the challenges for BWPs in geological disposal conditions is their swelling behavior due to water uptake. This swelling, if sufficiently important, could lead to mechanical coupling with the host rock, resulting in the application of pressure that could damage it. Consequently, the swelling behavior of BWPs must be considered in safety studies for the underground storage facility after site closure. The present work is a continuation of a previous one and focuses on investigating both experimentally and numerically the BWPs’ swelling behavior due to water uptake under confined leaching conditions. The swelling of simplified BWPs was experimentally monitored for about 2.5 years during leaching tests under constant counterpressure. The numerical model is extended from a previous work that incorporates coupled homogenization of transport terms (diffusion, permeation, osmosis) with mechanics via Maxwell's viscoelastic model. An original nonlinear poro‐viscoelastic model taking into account large strains is proposed in this paper to better model the BWPs leaching behavior under confined conditions. The experimental results of leaching tests under constant counterpressure are generally well predicted by the resulting numerical model. The role of the poorly soluble salts BaSO4 within the solid BWP matrix is investigated.
Exploring the Potential of Bifunctional Polybenzoxazines Containing Schiff Bases for Superhydrophobic and Anticorrosion Properties: A Comprehensive Study on Synthesis and Characterization
Authors: Madesh Priyanka , Krishnasamy Balaji , Kumarasamy Vasuki , Kannaiah Kasthuri Periyaiay 
Published: November 2024

ABSTRACTTwo series of bifunctional benzoxazines (HC‐benz and HA‐benz) containing Schiff bases (HC and HA) were synthesized through Mannich condensation. The structural confirmation of the Schiff base containing hydroxyl derivatives and benzoxazines was carried out using ATR‐FTIR, HRMS, and 1H‐NMR spectroscopic techniques. The cure behavior and thermal stability were studied using DSC and TGA, respectively. Among the different benzoxazines studied, the HC‐jfm and HA‐jfm benzoxazines exhibited the lowest curing temperature of 216°C and 211°C, respectively. Both poly(HC‐dde) and poly(HA‐dde) showed higher char yield value of 41% at 850°C. The values of LOI and heat resistance index calculated from TGA data infer that these benzoxazines in particular poly(HC‐dde) and poly(HA‐dde) can be conveniently used for self‐extinguishing and heat‐resistant applications which was proved by achieving V0 rating during vertical flammability test. Results from EIS studies showed that poly(HC‐jfm) and poly(HA‐jfm) exhibited corrosion protection efficiency of 99.19% and 99.99%. The value of water contact angle results suggested that all the synthesized polybenzoxazines are hydrophobic in nature, whereas the poly(HC‐ddm) and poly(HA‐ddm) revealed the superhydrophobic behavior with values of 149o and 159o, respectively. The cotton fabric coated with polybenzoxazine exhibits excellent resistance to UV and chemicals. Data from different studies infer that these benzoxazines can be used in the form of coatings for thermally stable, anticorrosive, and superhydrophobic high‐performance applications.
Stability of Stochastic Differential Delay Systems With Integral/Fragment‐Integral Term and Applications
Authors: Hou Xuping , Zong Xiaofeng , Mu Junqi 
Published: November 2024

ABSTRACTThis article investigates the stochastic stability of stochastic differential delay systems (SDDSs) with path information and their applications in consensus control of multi‐agent systems (MASs) based on the path information feedback. Here, the integral path information and fragment‐integral path information are considered, respectively. The mean square (m.s.) and almost sure (a.s.) exponential stability criteria of the SDDSs with path integral information are established respectively according to the two types of path information. It is shown that the fragment‐integral term may work positively for stochastic stability. Moreover, the obtained stochastic stability theorems are applied to design a distributed proportional integral/fragment‐integral control protocol and establish consensus conditions for stochastic MASs under proportional‐integral (PI)‐type controls. Finally, the effectiveness of the results is verified through two simulation examples.
Management Controls for Contributing to the Promotion of Sustainable Development in Public Sector Organizations—Status Quo and Further Research
Authors: Bauer Philumena , Greiling Dorothea 
Published: November 2024

ABSTRACTThe public sector plays a crucial role in enabling sustainable development (SD) as a policymaker, regulator, and through its own public sector organizations (PSOs). In addition to nonfinancial reporting on sustainability initiatives, PSOs must implement sustainability management controls (SMCs) to promote SD. These controls include environmental, social, and governance aspects aligned with the 17 Sustainable Development Goals. Through a systematic literature review, this study aims to identify the current state of literature on SMCs that promote SD in PSOs. This study addresses this gap in the literature by providing future directions for improving sustainability practices in PSOs. The current state of SMCs is advanced, but lacks a holistic perspective.
Hypothermia Exposes Hidden Epitopes in Influenza A Hemagglutinin and Potentiates the Binding of Neutralizing Antibodies
Authors: Singh Puneet K. , Stan Razvan C. 
Published: November 2024

AbstractInfluenza viruses are an important cause of human morbidity and mortality. Influenza uses hemagglutinin, a trimeric surface protein whose monomers are composed of a head and a stalk domain, for immune evasion and cell entry. As the head domain is under constant antigenic drift, eliciting neutralizing antibodies through vaccination against its evolutionarily more conserved stalk domain is a key goal in the treatment of this infection. It is unknown how temperature affects the formation of hemagglutinin‐antibody complexes, particularly with respect to temperatures relevant for the human respiratory tract. Using molecular dynamics simulations and free energy calculations, we determined that bending of hemagglutinin's head domains, an initial step in the process of cell attachment, is present at hypothermia (36 °C), but not at higher temperatures. These conformational changes lead not only to exposure of new epitopes in its stalk domains, but also to enhanced binding of a neutralizing antibody.
Preparation, Characterization, and Antibacterial Activity of Amino Acids Grafted‐Chitosan/Glycerophosphate Hydrogel
Authors: Dai Su Ping , Zhou Hui Yun , Ren Li Jun , Jiang Shuai Qiang , Wang Yin , Chen Ya Wei , Chen Jun Liang , Park Hyun Jin 
Published: November 2024

AbstractIn this paper, L‐lysine (Lys), L‐glutamic acid (Glu), and L‐glutamine (Gln) ‐grafted chitosan (CS) polymers (AA‐g‐CS) are prepared by a one‐pot method, employing EDC/NHS as coupling agent. Then AA‐g‐CS glycerol phosphate hydrogels (AA‐g‐CS/GP hydrogel) are prepared by physical cross‐linking method. The prepared AA‐g‐CS/GP hydrogel has a dense 3D network structure, which facilitates the loading of drugs. The pore size and wall of hydrogels are affected by amino acid types (Lys, Glu and Gln). Berberine hydrochloride (BBH) is encapsulated in the three‐dimensional network structure of the hydrogel. Escherichia coli (Gram‐negative bacteria, E. coli) and Staphylococcus aureus (Gram‐positive bacteria, S. aureus) are selected as model bacteria, and the antibacterial properties of BBH@AA‐g‐CS/GP hydrogel are investigated by AGAR drilling method and turbidimetric method. The results show that BBH@AA‐g‐CS/GP hydrogel has a better inhibition effect on S. aureus than that on E. coli. The BBH@AA‐g‐CS/GP hydrogel can achieve long‐term inhibition of E. coli and S. aureus within 24 h. Therefore, AA‐g‐CS/GP hydrogel is an excellent carrier for BBH and is expected to be applied extensively in wound healing, tissue regeneration, and cell culture.
Synthesis of Diones via Visible Light‐Induced Oxidation of α‐Hydroxy Ketone Derivatives
Authors: Zhao Chenyue , Yang Heran , Hu Shuo , Liu Yaqian , Cheng Dongping , Xu Xiaoliang 
Published: November 2024

AbstractA visible light‐induced oxidation of α‐hydroxy ketone derivatives is reported, which is carried out in the presence of CBrCl3 and ruthenium photocatalyst, and the corresponding diketones are obtained in 49‐95% yields. This reaction has the advantages of moderate to excellent yields, good functional group tolerance, and mild reaction condition. The free radical reaction process was confirmed by the addition of radical scavenger 2,2,6,6‐tetramethylpiperidi‐1‐oxy (TEMPO). The fluorescence quenching experiment indicated that CBrCl3 was participated in the oxidation quenching cycle.
Dual Responsive Magnetic DCR3 Nanoparticles: A New Strategy for Efficiently Targeting Hepatocellular Carcinoma
Authors: Jia Lina , Dai Yuguo , Xu Yingchen , Sun Hongyan , Gao Han , Hao Haiyang , Wang Luyao , Xu Junjie , Shang Juanjuan , Li Guangming , Xu Ye , Feng Lin 
Published: November 2024

AbstractHepatocellular carcinoma (HCC) is a major cause of cancer deaths globally. Unlike traditional molecularly targeted drugs, magnetically controlled drug delivery to micro/nanorobots enhances precision in targeting tumors, improving drug efficiency and minimizing side effects. This study develops a dual‐responsive, magnetically controlled drug delivery system using PEGylated paramagnetic nanoparticles conjugated with decoy receptor 3 (DCR3) antibodies. The clusters demonstrate capabilities for long‐range, magnetically driven control and molecular chemotaxis. Paramagnetic PEGylated particles form vortex‐ and liquid‐like drug moieties within a magnetically controlled system. Vortex‐like nanoparticle clusters exhibit high controllability and countercurrent movement, while liquid‐nanoparticle robot clusters display greater deformability. Upon loading with DCR3 antibodies, the particles navigate along DCR3‐protein gradients in blood and tissue, effectively targeting liver tumor sites in vivo. Clusters of DCR3‐coupled magnetic nanoparticles target cells that highly express DCR3, thereby effectively inhibiting tumor cell proliferation and migration. Compared with conventional nanomedicine, DCR3‐coupled magnetic nanoparticle clusters are capable of delivering controlled drugs over long distances and responding in a molecular‐targeting manner. This research is expected to significantly impact the field of precise tumor drug delivery.