bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing a Quality Improvement Initiative to Screen for Dementia in a Down Syndrome Specialty Clinic
Authors: Santoro Stephanie L. , Harisinghani Ayesha , Bregman Caroline , Cottrell Clorinda , Pulsifer Margaret B. , Shaffer Mikayla , Torres Amy , Skotko Brian G. , Oreskovic Nicolas M. 
Published: November 2024

ABSTRACTUsing quality improvement methods, we aimed to implement a protocol to assess for dementia among adults with Down syndrome (DS). To track implementation, interval retrospective chart review of patients with DS with visits to the Massachusetts General Hospital DS Program (MGH DSP) was conducted quarterly. The impact of a newly implemented protocol created and informed by clinical experts in the MGH DSP including laboratory tests, imaging, referrals, and screening tools for dementia and mental health concerns, was analyzed using statistical process control charts. From December 2021 to December 2022, the MGH DSP developed and implemented a new clinical protocol to screen for dementia in 44 adults with DS, ages 40 and above, at a total of 48 visits. We found high rates of completion of two screening surveys (85% and 81%, respectively) and an 84% adherence to our overall protocol elements by clinical staff. Among those with dementia‐like symptoms, medical evaluation was collected and summarized. We show that it is possible to successfully implement a new protocol, including the use of a dementia screener, in line with published evidence‐based care guidelines for adults with DS. We present our protocol as one successful approach focused on pre‐visit screening for symptoms of dementia and mental health concerns and evaluating for co‐occurring medical conditions in adults with DS.
Light‐Induced Tetrafluoroethylation/Cyclization of N‐Methacryloyl‐2‐phenylbenzoimidazoles with 1,2‐Dibromotetrafluoroethane
Authors: Deng Zhoubin , Lv Yuyu , Wang Ke‐Hu , Huang Danfeng , Wang Junjiao , Hu Yulai 
Published: November 2024

AbstractVarious N‐methacryloyl‐2‐arylbenzoimidazoles react with 1,2‐dibromotetrafluoroethane in the presence of photocatalyst 4CzIPN irradiated by 10 W blue LED to provide 5‐(3‐bromo‐2,2,3,3‐tetrafluoropropyl)‐5‐methylbenzo[4,5]‐imidazo[2,1‐a]isoquinolin‐6(5H)‐ones in good yield. The reaction proceeds through a sequential tetrafluoroethyl radical addition/cyclization pathway. The wide substrate scope, good functional group tolerance, and ease of scale‐up of this protocol are expected to promote its potential applications in pharmacy.
Full Conjugation in a Polymer with Non‐conjugated Piperazine‐2,5‐dione Units via Energy‐minimized Lactam‐to‐Lactim Tautomerization Enables Water‐gated Transistor Fluoride Sensors
Authors: Zhao Naixin , Jeon Sung Jae , Yuan Yi , Venkateswarlu Samala , Stella Andrew , Papazotos Jimmy , Li Yuning 
Published: November 2024

AbstractPiperazine‐2,5‐dione (glycine anhydride, GA) has recently emerged as a valuable precursor for high‐performance π‐conjugated polymer semiconductors in organic electronics. We utilized GA to design a novel bisindolin‐dihydropiperazine (IDHP)‐based conjugated polymer, PIDHPTT, for aqueous chemical sensing. In the isatin‐flanked monomer, GA exists as a non‐conjugated lactam (DHP‐NH) but converts to a conjugated lactim (DHP‐OH) form within the polymer. Density functional theory (DFT) calculations show that this conversion is driven by energy minimization via extended π‐conjugation. Neighboring DHP units in the lactim form facilitate this process through π‐bridges, demonstrating a vinylogous effect, which has previously only been observed in small molecules. This is the first study to report such a long‐range vinylogous effect in a polymer due to the collective synergy of numerous functional groups. The OH groups in the lactim DHP interact more strongly with fluoride ions than other halides. PIDHPTT exhibits significant changes in optical absorption, electrochemical impedance, and charge transport in response to fluoride ions, which differ from responses to other halides. A water‐gated organic field‐effect transistor based on PIDHPTT shows excellent sensitivity and selectivity for fluoride ions, demonstrating the potential of this polymer design for chemical sensing applications.
Stimuli‐Responsive Amino Acid Based Polymeric Nanomicelles With Antimicrobial and Anticancer Activities
Authors: Bharatiya Debasrita , Parhi Biswajit , Singh Khumukcham Saratchandra , Manavathi Bramanandam , Paik Pradip 
Published: November 2024

ABSTRACTHerein this work, a biocompatible polymer synthesis approach has been established for the designing of α‐methoxy‐ω‐amino poly(ethylene glycol)‐L‐glutamate‐L‐aspartate [MeO‐PEG‐NH‐b‐(L‐GluA)5‐b‐(L‐AspA)18]/[PEG‐b‐PBLG‐b‐PBLA] triblock copolymeric nanomicelles by using α‐methoxy‐ω‐amino PEG as a macro initiator via modified ring‐opening polymerization. The colloidal stability, remarkable protein folding properties, and distinct morphology of the prepared polymer are confirmed. The microscopic analysis confirms the formation of nanomicelles with an average diameter of 13 nm to 22 nm for [PEG‐b‐PBLG‐b‐PBLA] and [PEG‐b‐PBLG], respectively. The copolymers show an effective influence on self‐assembly behavior with respect to change in temperature and pH. The cellular inhibition properties of the block copolymeric micelles is confirmed through in vitro study against the MDA‐MB‐231 cancer cells. The calculated IC50 values for [PEG‐b‐PBLG] and [PEG‐b‐PBLG‐b‐PBLA] copolymers are found to be 560.340 ± 34.107 μg/mL and 750.468 ± 47.312 μg/mL, respectively. The minimum inhibitory concentration (MIC) for antibacterial activity is calculated to be 0.8 μg /mL against gram (−)
Escherichia coli
(
E. coli
) of triblock copolymer. Therefore, the attachment of a new amino acid block in the [PEG‐b‐PBLG‐b‐PBLA] copolymer enhances the thermal stability, protein folding properties, colloidal stability, antibacterial activities, and biocompatibility, on account of which the synthesized triblock copolymer nanomicelle could be beneficial for antimicrobial and anticancer activities.
Identification of potentially causative drugs associated with hypotension: A scoping review
Authors: Sari Nurunnisa , Jaehde Ulrich , Wermund Anna Maria 
Published: November 2024

AbstractDrug‐induced hypotension can be harmful and may lead to hospital admissions. The occurrence of hypotension during drug therapy is preventable through increased awareness. This scoping review aimed to provide a comprehensive overview of antihypertensive and nonantihypertensive drugs associated with hypotension in adults. A systematic literature search was conducted using MEDLINE, Embase and Cochrane Library, focusing on studies from January 2013 to May 2023. Search terms were developed to capture key concepts related to hypotension and adverse drug events in adults while excluding terms related to allergic reactions, phytotherapy and studies involving paediatric, pregnant or animal populations. The eligibility criteria included a wide range of study types evaluating hypotension as an adverse drug event across all healthcare settings. Relevant information was extracted from the included studies, while identified drugs associated with hypotension were categorised into drug classes. The review was reported using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses Extension for Scoping Reviews checklist. In 97 eligible studies, we identified 26 antihypertensive drugs grouped into nine different antihypertensive classes and 158 other drugs grouped into 22 other drug classes. Common antihypertensive classes were angiotensin‐converting enzyme inhibitors, beta blockers and diuretics. Frequently reported nonantihypertensive classes were neuroleptics, alpha‐1 blockers for benign prostatic hyperplasia, benzodiazepines, opioids and antidepressants. The results highlight the importance of healthcare professionals being aware of nonantihypertensive drugs that can cause hypotension. This review provides a basis for future systematic reviews to explore dose‐dependence, drug–drug interactions and confounding factors.
Nano‐alloy Catalysts for Methanol Synthesis from CO2 Hydrogenation
Authors: Zhang Yanmin , Lian Fangci , Sun Shuzhuang , Qiu Hengshan 
Published: November 2024

AbstractNano‐alloy catalysts (NACs), which differ appreciably from monometallic catalysts, take on superior intrinsic features in surface microstructure, surface electronic properties, homogeneity in nanoscale, etc., endowing them with attractive prospects in heterogeneous catalysis. In particular, methanol synthesis from CO2 exhibits high potentials in terms of alternative energy sources to fossil fuels and NACs have shown promising performance in promoting the reaction. However, there still lacks of the bottom‐up catalysts design as well as the unanimous insight regarding the mechanistic understanding. Herein, we present a comprehensive overview of the physico‐chemical properties and the fabrication approach to NACs with high catalytic performance in the CO2 hydrogenation to methanol. Additionally, the progresses of NACs were comprehensively summarized in terms of mechanisms. Finally, some thinking about the further relevant studies on NACs is outlooked with the aim to provide new insights for achieving the precise design and controllable properties of NACs.
Innovative Leadership and Sustainable Development: Exploring Resource‐Efficient Strategies Among Indian Managers
Authors: Sathiyaseelan Anuradha , Balasundaram Sathiyaseelan , Zirkler Michael , Patangia Bishal 
Published: November 2024

ABSTRACTGlobal sustainability challenges demand innovative leadership approaches, particularly in resource‐constrained environments where traditional models may fall short. The current study aimed to explore the need for adaptive, resource‐efficient leadership by examining key traits such as empathy, inclusivity, adaptability, and intuitive decision‐making that allows managers to balance immediate organizational demands with long‐term sustainability goals. A Qualitative‐Interpretative Phenomenological Approach was adopted. A total of 28 senior Indian managers were interviewed to understand traits aligned with stakeholder theory and the resource‐based view, positioning them as strategic assets for achieving sustainable competitive advantage. Findings revealed that culturally resonant practices of frugality and resilience support social innovation and organizational resilience, contributing to broader sustainable development objectives. Further, it advances sustainable leadership literature by showcasing how resource efficiency and contextual adaptability can foster impactful, sustainable practices, particularly within emerging economies.
Lithium Ion Batteries: Characteristics, Recycling and Deep‐Sea Mining
Authors: Devanahalli Bokkassam Samrudh , Nambi Krishnan Jegatha 
Published: November 2024

ABSTRACTLithium ion batteries (LIBs) have brought about a revolution in the electronics industry and are now almost a part of our everyday activities. They are on the verge of finding application in almost every electronic rechargeable device and have a bright future ahead. With the recent discovery of substantial reserves of lithium in India, along with the favourable government policies for the usage of electric vehicles (EVs), LIBs are expected to play a major role in meeting sustainable energy goals. Though LIBs have become a commercial success, they face many challenges, such as high cost of production, thermal runaway and overcharging, that might hamper their extensive use. Many research studies have been conducted regarding the operation of LIB, with safety being a concern. With rapid technology development, going nanoscale for LIB production has become achievable and valuable as it has been reported to increase the shelf life of the battery. In this review, recycling of spent LIBs is discussed, as the extraction of the leftover lithium and other minerals is possible through recycling process. The advantages and drawbacks of deep‐sea lithium mining have been discussed, as it is explored as an alternative to major lithium sources due to the rapid depletion of land mining sources. Its impact on the environment and the mineral market has been assessed. This review paper attempts to give an overview of all the vital characteristics of an LIB, such as life cycle, fast charging and overcharging, while covering strategies for overcoming challenges faced in the functioning of LIBs.
Mapping the Theory of Consumption Values: A Systematic Review Using the TCCM Approach
Authors: Sharma Chandni , Kushwah Shiksha 
Published: November 2024

ABSTRACTThe theory of consumption values (TCV) explains consumer behavior by examining the underlying values that drive consumption choices. TCV is prominent across various disciplines, including marketing, information systems, psychology, business, and management. This study systematically reviews articles that have applied TCV, making several key contributions: (1) it presents a synthesis of existing literature on TCV by including studies from 1991 to 2024, providing a comprehensive and updated perspective on the field's evolution; (2) it employs the Theory–Contexts–Characteristics–Methods (TCCM) framework to explore major theories, contexts (industrial and geographical), characteristics (antecedents, mediators, moderators, and outcomes), and methods (research methodologies and data analysis techniques); (3) it also incorporates bibliometric techniques, such as cluster analysis and bibliographic coupling, to visualize the cumulative advancements in TCV research and reveal the intellectual structure, key themes, and influential works; and (4) it systematically categorizes and summarizes consumption values and their measures according to product and service contexts examined over the past three decades. Hence, the findings of the study offer several implications for marketers and academics, suggesting avenues for future research and new applications of TCV.
The Effects of Lamium garganicum L. Subsp. lasioclades (Stapf.) R. Mill Plant Against Fibroblast (U2OS Cell), Acetylcholinesterase, Glutathione S‐Transferase: An In Vitro, In Silico Biological Activity Screening Study
Authors: Bozkurt İlkan , Sabancilar İlhan , Kiliç Ömer , Bayrakdar Alpaslan , Paçal Nurettin , Aras Abdülmelik 
Published: November 2024

ABSTRACTIn this study, some biological activities of extracts of Lamium garganicum subsp. lasioclades (Lgl) have been evaluated as well as identified the phenolic composition. Concentration ranges of 31.25, 62.5, 125, 250, and 500 µg/mL were applied to determine the extract's anticancer properties. Significant results were obtained against the osteosarcoma cell line (U2OS cell) compared to normal human umbilical vein endothelial cells (HUVEC). To determine the antioxidant activities, ABTS, DPPH, FRAP, and CUPRAC methods were studied in vitro. Enzyme inhibition effects of methanol extract against the glutathione S‐transferase (GST) and acetylcholinesterase (AChE) enzymes were investigated. IC50 values were calculated as 12.96 µL/mL for AChE and 13.02 µg/mL for GST, respectively. The phenolic contents of the plant extract were analyzed by HPLC. The interaction mechanisms of protein–ligand complexes formed by AChE and GST receptors with gallic acid and rutin were investigated by molecular docking studies. The stability of the complexes formed between receptors and ligands was confirmed by root mean square deviation (RMSD), root mean square fluctuation (RMSF), number of average hydrogen bonding interactions (Hb), and radius of gyration (Rg) analyses obtained from 100 ns molecular dynamics simulations.
The Medicinal Potential of Rosa centifolia L.: Integrating Botany, Geographical Distribution, Pharmacology, Ethnobotanical Uses, Phytochemistry, and Toxicology
Authors: Meziouy Omayma El , Youssoufi Moulay Hfid , Lafdil Fatima Zahra , Legssyer Abdelkhaleq , Bnouham Mohamed , Ziyyat Abderrahim , Mekhfi Hassane 
Published: November 2024

ABSTRACTRosa centifolia L. is widely used to treat various health issues such as digestive, respiratory, and cardiovascular ailments. This study aims to assess the ethnopharmacological, phytochemical, pharmacological, and toxicological research on R. centifolia, combining traditional knowledge with modern computational techniques. A literature survey from 2000 to 2024 using Science Direct, Web of Science, and Scopus identified relevant studies. Traditionally used in countries such as Morocco, China, India, and across Europe and Asia, R. centifolia L. contains compounds like alkaloids, glycosides, saponins, flavonoids, terpenoids, tannins, lignans, and steroids. Its extracts demonstrate various pharmacological activities, including anti‐inflammatory, antihuman immunodeficiency virus (HIV), antitussive, vasorelaxant, hepatoprotective, nephroprotective, antidepressant, antiulcer, immunostimulatory, cardioprotective, antimicrobial, and antioxidant effects. This work provides a comprehensive understanding of R. centifolia’s therapeutic potential, chemical composition, and safety profile, highlighting its significant potential for treating various diseases and warranting further research.
New 5, 6, 7, 8‐Tetrahydro‐Isoquinolines Bearing 2‐Nitrophenyl Group Targeting RET Enzyme: Synthesis, Anticancer Activity, Apoptotic Induction and Cell Cycle Arrest
Authors: Saddik Abdelreheem A. , Bakhite Etify A. , Hassanien Reda , Farhan Naseer , Sayed Eman M. , Sharaky Marwa 
Published: November 2024

ABSTRACTIn this work, we synthesized new 5, 6, 7, 8‐tetrahydroisoquinolines and 6, 7, 8, 9‐tetrahydrothieno[2, 3‐c]isoquinolines derivatives, and the structures of these new compounds were confirmed with different spectroscopic techniques. Furthermore, the anticancer activities of these compounds were assessed against eight tumor cell lines and one normal human skin fibroblast cell line (HSF). Subsequently, IC50 values of the synthesized compounds were determined for two specific cancer cell lines. Compound 3 exhibited the most potent antiproliferative activity against the HEPG2 cell line, whereas compound 9c demonstrated superior efficacy against the HCT116 cell line. Moreover, the mechanism of action for compound 3 on HEPG2 cells using flow cytometry and Annexin V‐FITC apoptosis analysis was studied. Compound 3 caused cell cycle arrest at the G2/M with a 50‐fold increase in apoptosis of the HEPG2 cell line. Finally, a molecular docking study was conducted to assess the inhibitory potential of compounds 3 and 7 against the RET enzyme. Results indicated that compounds 3 and 7 bind to the RET enzyme with binding energies of −5.2 and −5.6 kcal/mol, respectively. Although these values suggest inhibitory activity, they are less potent than the standard inhibitor, alectinib, which exhibits a binding energy of −7.2 kcal/mol.
Giant Cysticercosis of the Right Kidney: A Case Report
Authors: Zhang Yumeng , Tan Huaqing , Gao Xukun , Wang Yuxuan , Cao Yuntai 
Published: November 2024

ABSTRACTCysticercosis, although reported in several parts of the body, especially the liver, lesions occurring in the kidney are particularly rare. We report a 58‐year‐old female patient with intermittent epigastric pain, who was found to have a huge occupancy of the right kidney on computed tomography (CT) and magnetic resonance imaging (MRI), which was confirmed to have a predominantly cystic component, with no clear enhancement on CT images after injection of contrast medium, and significant enhancement of the peritoneum and septum visible on MRI. This case reports a case and its rarity of cysticercosis occurring in the kidney.
Sympathetic Ophthalmia Following an Evisceration Surgery—A Case Report
Authors: Javed Rahmah , Al‐Khairy Saba , Khan Hamna , Raheel Hamna , Moeed Abdul , Surani Salim 
Published: November 2024

ABSTRACTSympathetic ophthalmia (SO) is a rare, bilateral, granulomatous, panuveitis following perforating trauma or surgical intervention in one eye. Here, and to the best of knowledge, we report the first case of SO following an evisceration surgery in Pakistan. A 32‐year‐old, Pakistani, female presented with pain and decreased visual acuity in her right eye, at Civil Hospital, Karachi, 1 week after an evisceration surgery was performed on her left eye, following corneal perforation due to unresolved keratitis. Diagnosis of SO was made on the basis of clinical presentation and confirmed by slit lamp examination which revealed mutton fat keratic precipitates, posterior synechiae, and optic disc swelling. She was administered high‐dose corticosteroids to which she did not respond. She was then prescribed methotrexate which resolved the inflammation and improved visual acuity. Initiating prompt treatment for the sympathizing eye led to effective management of the patient and prevented complete blindness.
In‐Situ AFM Study of Zinc Electrodeposition in a Deep Eutectic Solvent
Authors: Wang Ting , Xu Xintao , Li Kaixuan , Fan Yuteng , Yan Hao , Zhu Feng , Zhou Jianzhang , Yan Jiawei , Mao Bingwei 
Published: November 2024

AbstractZinc‐based batteries are promising for applications in large‐scale energy storage and other scenarios due to their high voltage, large theoretical capacity, and abundant reserves. Compared to traditional aqueous electrolytes, deep eutectic solvents (DESs) offer advantages such as wide electrochemical window, good stability, and fewer parasitic reactions. They can effectively regulate the growth morphology of zinc deposits and suppress dendrite formation during zinc deposition/stripping processes. However, there is currently a lack of direct observation for underlying mechanisms of zinc deposition/stripping processes in DESs. In this study, combined with electrochemical methods, in‐situ atomic force microscopy (in‐situ AFM) has been utilized to investigate the deposition behavior of zinc metal from ZnCl2 precursor in a deep eutectic solvent composed of choline chloride and ethylene glycol (ethaline). Cyclic voltammetric measurements indicate that zinc deposition is a kinetically controlled process. And in‐situ AFM reveals the hexagonal morphology and layered deposition of zinc on highly oriented pyrolytic graphite (HOPG). Our observations benefit the understanding of the kinetics of zinc deposition/stripping in deep eutectic solvent ethaline at a microscopic level.
Hierarchically structured, Janus optical nanoengineered wastepaper for switchable radiative cooling/heating
Authors: Song Zifan , Zhang Zipeng , Zhang Xueting , Liu Jingyang , Wang Wanjie , Wang Jianfeng , Jin Xiuxiu 
Published: November 2024

AbstractSwitchable radiative cooling/heating holds great promise for mitigating the global energy and environmental crisis. Here, we reported a cost‐effective, high‐strength Janus film through surface optical engineering waste paper with one side decorated by a hydrophobic polymeric cooling coating consisting of micro/nanopore/particle hierarchical structure and the other side coated with hydrophilic MXene nanosheets for heating. The cooling surface demonstrates high solar reflectivity (96.3%) and infrared emissivity (95.5%), resulting in daytime/nighttime sub‐ambient radiative cooling of 6°C/8°C with the theoretical cooling power of 100.6 and 138.5 W m−2, respectively. The heating surface exhibits high solar absorptivity (83.7%) and low infrared emissivity (15.2%), resulting in excellent radiative heating capacity for vehicle charging pile (~6.2°C) and solar heating performance. Impressively, the mechanical strength of Janus film increased greatly by 563% compared with that of pristine waste paper, which is helpful for its practical applications in various scenarios for switchable radiative thermal management through mechanical flipping. Energy‐saving simulation results reveal that significant total energy savings of up to 32.4 MJ m−2 can be achieved annually (corresponding to the 12.4% saving ratio), showing the immense importance of reducing carbon footprint and promoting carbon neutrality.