bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent Patterns in Patients With Nasopharyngeal Caricinoma and Risks Leading to Inaccurate Delineation in Marginal Failure in the Era of Intensity‐Modulated Radiotherapy
Authors: Zhang Shu , Zeng Ni , Yang Jiangping , Han Jiaqi , He Jinlan , Duan Baofeng , Chen Xiaoqiang , Gou Xiaofang , Zhu Fubin , Liu Huizhen , Zeng Ming , Yan Di , Chen Nianyong 
Published: November 2024

ABSTRACTObjectiveTo investigate the failure patterns of recurrent nasopharyngeal carcinoma (NPC), especially to identify the relationship between the recurrent‐prone anatomic structures and the tumor regression sites after the introduction of chemotherapy (IC).MethodA cohort of 1121 non‐metastatic patients with NPC was retrospectively enrolled. The pretreatment and recurrent images of each patient were registered to the planning CT. Tumor regression sites after IC (Vicr) overlapped with recurrent tumor (rGTV) were evaluated for the delineation accuracy and dose sufficiency in marginal failure patients.ResultsA total of 126 (11.24%) experienced tumor recurrence. Re‐evaluation of 12 patients with local marginal recurrence, their rGTV within Vicr predominantly located at choanae, sphenoidal sinus, and cavernous sinus. The regression sites did not receive the full 70 Gy but over half receiving with 60Gy.ConclusionAnalysis from marginal failure that exempts tumor regression sites from GTV or an insufficient prescription dose of less than 70 Gy may contribute to marginal failure.
Public health policy for temporary seasonal workers with chronic hepatitis B in high‐income countries: A comparative analysis
Authors: Fox Haylee , Mude William , Vaughan Geraldine , Preston Robyn , O'Mullan Catherine , Gu Zhihong 
Published: November 2024

AbstractIssue AddressedThis study examines Australia's Hepatitis B public health policies with a focus on the Pacific Australia Labour Mobility scheme seasonal workers as a priority population. The aim is to evaluate if Australia's Hepatitis B public health policies adequately address health disparities and equitable access to health care for seasonal workers as a priority population. We draw comparisons with the public health policies of New Zealand and Canada, to understand how these nations approach similar health concerns among their temporary seasonal workers.MethodsA health policy analysis was conducted on the public health Hepatitis B policies in Australia and then compared with those in Canada and New Zealand. Due to the nature of the study question, the review had a major focus on grey literature. The search was undertaken in two stages, including (1) Google search engine and (2) targeted websites. Basic document data was produced in descriptive summaries. Any data either explicitly or inexplicitly relating to the elimination of hepatitis B or equity towards the inclusion of seasonal workers was produced as analytical summaries through multiple revisions.ResultsNineteen documents were identified, predominantly from Australia. Although Hepatitis B public health policies emphasised testing and awareness in priority populations, specifically mentioning seasonal workers as a priority population was absent in all three countries.ConclusionsThe study underscores the exclusion of temporary seasonal workers in public health policies and strategies as a human rights issue, conflicting with principles of equity and equitable access to health care. Despite acknowledging challenges for temporary visa holders, policies lack specific provisions for seasonal workers. Addressing this gap is crucial for health equity and inclusive health systems.So What?Our findings highlight the need to prioritise equity for temporary seasonal workers to achieve hepatitis B elimination goals by 2030. Exclusion from public health policies is a human rights concern, impacting access to quality health care. This study advocates for inclusive policies explicitly recognising temporary seasonal workers as a priority population, aligning with international human rights commitments to health care for all.
Tracking Telehealth Needs for Individuals With Sickle Cell Disease Through the COVID‐19 Pandemic: A Cross‐Sectional Survey Study
Authors: Treadwell Marsha , Du Lisa , Lawrence Yemi , Gaspar Maxine , Hassell Kathryn , Shah Sanjay , Akpan Moses , Crook Nicole , Taylor Marcia , Gopal Srila ,   For the Pacific Sickle Cell Regional Collaborative
Published: November 2024

ABSTRACTBackground and AimPervasive disparities characterize sickle cell disease (SCD) care, including limited access to SCD specialists. Rapid deployment of remote healthcare provision and support during the COVID‐19 pandemic provides an opportunity to understand telehealth barriers/facilitators for SCD. We aimed to evaluate telehealth experiences and satisfaction for routine visits among adults and caregivers of children with SCD within a US regional collaborative.Methods151 adults ≥ 18 [median (IQR) = 36 (28, 43) years], and 94 caregivers [median child age (IQR) = 12 (7, 14) years] completed a 30‐item online survey in 2021 assessing systems issues such as reliable Internet; health information sharing; and consumer focus (e.g., visit started on time). A multivariable logistic regression model was used to evaluate relations between independent variables and the outcome overall satisfaction with telehealth.ResultsPatients were primarily diagnosed with sickle cell anemia (60.8%) and prescribed hydroxyurea (57.6%). Satisfaction with telehealth was high (> 90%), but 60.6% of caregivers gave the highest rating compared with 44.9% of adults (p = 0.02). Few accessibility/technical issues were cited, however, caregivers reported more often having home support for telehealth (80.9% vs. 63.6%, p = 0.003). In multivariable analyses, participants seen in large centers (> 200) were more likely to give the highest satisfaction ratings compared with those in smaller centers (< 100, aOR: 2.33; 95% CI: 1.21, 4.48, p = 0.01); however, those who needed help from a telehealth navigator were less likely to give the highest telehealth experience rating versus those who did not need help (aOR: 0.37; 95% CI: 0.19, 0.71, p = 0.003).ConclusionViews of telehealth were favorable, although caregivers reported greater satisfaction and resources compared with adults with SCD. It remains important to identify factors related to telehealth utilization and efficacy for SCD populations in varied geographies and settings, to ensure equity in access.
Impacts of Buoyancy and Joule Heating on Unsteady MHD Fluid Flow Along a Semi‐Infinite Vertical Porous Plate With Dufour, Chemical Reaction, and Radiation Effect
Authors: Khayer Saleem Jabed Al , Chakraborty Shyamanta 
Published: November 2024

ABSTRACTAn analytical solution for unsteady, incompressible, laminar MHD fluid flow involving mass and heat transfer along a semi‐infinite vertical moving flat plate in a porous medium have been studied in this paper. Effects of heat radiation and absorption, Joule heating, Dufour, thermal and solutal buoyancy, and first order chemical reaction of are discussed under suitable physical conditions. It is postulated that the plate will migrate in the fluid's motion's direction due to the presence of a uniform magnetic field normal to the porous surface. The regular perturbation technique is used to solve the dimensionless governing equations. The mathematical derivations for fluid velocity, temperature, and concentration are evaluated; apart from that, skin friction, rate of mass and heat transfer at the plate are also expressed. The present outcomes are compared with previously obtained results and are found to be in excellent agreement. It is observed that the fluid velocity and temperature enhanced with thermal and solutal buoyancy forces as well as the Dufour effect. Also, with an increase in chemical reaction parameter, there is a decrease in fluid velocity, temperature, and concentration. Skin friction and Nusselt number increase with higher heat absorption parameter values. Schmidt number and chemical reaction parameter both lead to a rise in Sherwood number. Applications for these models have been observed in a number of industrial and technical methods.
Comparative histomorphological assessment of the osteoinductive capacity of a nanofibrillated cellulose‐based composite and autologous blood clot
Authors: Tuleubayev Berik , Kamyshanskiy Yevgeniy , Saginova Dina , Akhmetova Saule , Vinokurov Vladimir , Koshanova Amina , Kossilova Yekaterina 
Published: November 2024

AbstractPurposeThe present study aimed to evaluate and compare the effect of nanofibrillated cellulose (NFC)‐based composite with dicalcium phosphate dihydrate and an autologous blood clot (ABC) on the formation of new bone tissue in vivo by histological and histomorphometric assessment.Materials and MethodsA total of 72 rats with created femoral defects (2 mm) were used. The rats were divided into three groups: (1) with filling of the defect with an ABC, (2) NFC‐1—with filling of both the cortical plate and intramedullary space in the defect area, and (3) NFC‐2—with filling of only the intramedullary space in the defect area. Histological and histomorphometric analysis was performed to assess the healing of the bone defect after 14, 30 and 60 days.ResultsComplete closure of the cortical plate defect was detected in the NFC‐2 group on Day 30 (p < 0.0001). Moreover, in both NFC groups on the 30th and 60th days, ongoing osteogenesis was observed, characterized by a large volume of newly formed circular pattern bone tissue in the intramedullary space.СonclusionThis study demonstrated that the NFC‐based composite, which is located below the level of the cortical plate, tamponing only the intramedullary space (NFC‐2), improves bone tissue repair at the site of a bone defect of the cortical plate and has the potential of prolonged osteoinductivity.Level of EvidenceNot applicable.
Cold Tolerance and Physiological Response of Natural Overwintering Pomacea canaliculata in South China
Authors: Qin Zhong , Xiao Zeheng , Li Chuang , Liu Jimin , Yao Fucheng , Lin Xiaoting , Zhang Jiaen , Liu Yiman 
Published: November 2024

ABSTRACTPomacea canaliculata (Lamarck 1822), a freshwater gastropod indigenous to lower Del Plata Basin of Argentina, has become the most destructive and invasive rice pests in south China since its introduction in the 1980s. In Guangdong, the main production areas for double rice, most of P. canaliculata overwinter in paddy field ditches after late‐rice harvesting in mid‐November and diapause to temporarily to avoid the damaging effects of extreme low temperatures. This pest aroused from diapause and migrated to the paddy field after early‐rice reviving in next late March. Overwintering and cold tolerance of natural P. canaliculata have a non‐negligible impact on population dynamics and distribution in the following year. We tested the supercooling capability, levels of cryoprotectant synthesis, activity of antioxidant defense system (antioxidant enzymes and reduced glutathione), and degree of oxidative damage (concentration of malondialdehyde as an index of lipid peroxidation) monthly, using natural P. canaliculata samples with a size‐gender structure (i.e., juveniles, female, and male adults) from experimental ponds during the period of mid‐November to the following April. P. canaliculata survived the winter with a monthly death rate of 7%–16.5% in coldest January. The supercooling point (SCP) of overwintering P. canaliculata decreased initially before increasing subsequently with monthly changes in water temperature. P. canaliculata accumulated a high glycogen content before December, which depleted towards the end of January, while lipid content reached peak in January and depleted since February. Activity of antioxidant defense system of P. canaliculata exhibited significant monthly differences and showed relatively higher size heterogeneity than monthly variations. The results contribute to the knowledge of adaptability in overwintering P. canaliculata and help to understand the mechanism of the invasive success of this species.
Establishing an Interactive Sequence Database for Shiitake Cultivar Identification
Authors: Ou Jie‐Hao , Li Han‐Yun , Lu Yun‐Shen , Chen Chi‐Yu , Fan Yu‐Hsuan , Phang Guan Jie , Huang Guan‐Ying , Hsieh Sung‐Yuan , Huang Yin‐Tse 
Published: November 2024

ABSTRACTShiitake mushrooms (Lentinula edodes) hold significant cultural and economic value, particularly in Asia where they are extensively cultivated. The diversification of shiitake cultivars, driven by the need to adapt to various climatic conditions and cultivation methods, has resulted in over 200 distinct cultivars. Reliable identification of these cultivars is crucial for breeding, intellectual property protection, and effective genetic resource management. Traditional morphological methods are inadequate due to their subjectivity and labor‐intensive nature. This study leverages nanopore high‐throughput sequencing to comprehensively analyze the rDNA regions (SSU, ITS, LSU, IGS) of 41 shiitake strains from Taiwan's Bioresource Collection and Research Center (BCRC), comprising 5 wild strains, 33 commercial strains, and 3 wild‐commercial hybrids. Our results identified the IGS1 region as the most variable and suitable for cultivar differentiation. Consequently, we developed an interactive online database (https://github.com/Raingel/ShiitakeIGS1) that integrates 317 IGS1 sequences from Taiwan, Japan, and China. This platform allows users to upload their IGS1 sequences and identify similar cultivars through a user‐friendly interface, enhancing the precision and efficiency of shiitake cultivar identification.
More May Not Be Better: Comparison of Oncologic Outcomes Following Induction Chemotherapy Plus Chemoradiation and Chemoradiation Alone for Esophageal Adenocarcinoma
Authors: Yee Elliott J. , Read Jake , Ziogas Ioannis A. , Stuart Christina M. , Olsen Jeffrey , Kim Sunnie S. , Mitchell John D. , Meguid Robert A. , McCarter Martin D. , Mungo Benedetto 
Published: November 2024

ABSTRACTIntroductionThe oncologic benefit of induction chemotherapy (IC) before chemoradiation (CRT) compared to CRT alone for locally advanced esophageal and gastroesophageal junction (GEJ) adenocarcinoma is not well defined. We hypothesized that IC with CRT would improve survival and pathologic complete response rate compared to CRT alone.MethodsA retrospective review of patients with biopsy proven esophageal or GEJ adenocarcinoma treated with preoperative CRT and IC + CRT and surgical resection from 2007 to 2023 at a single institution was performed. First order outcomes were overall survival and pathologic complete response rate; secondary outcomes included disease‐free survival and distant metastasis failure. Subgroup analyses were conducted based on baseline characteristics and tumor‐specific features. Survival analysis was performed with Kaplan–Meier curves with log‐rank tests and Cox regression analysis.ResultsOf 205 patients that met inclusion criteria, 76 (38%) patients underwent IC + CRT. There were no significant differences in demographic or tumor‐specific characteristics between the two cohorts. There were no differences in the median overall survival between CRT and IC + CRT groups (47 months vs. not reached, p = 0.194). The rate of pathologic complete response in the overall cohort was 22%; IC + CRT was not associated with higher complete tumor response than CRT alone (20% vs. 23%, p = 0.557). There were no significant differences in any of the secondary outcomes between the two treatment paradigms.ConclusionsWe could not detect added oncologic benefit in survival or pathologic complete response with IC over CRT alone for resectable esophageal and GEJ cancer. Biomarker driven prospective studies exploring the optimal perioperative treatment regimens are warranted.
Electrodeposition of Zn–Al‐Layered Double Hydroxides With Interlayer Modification by Ibuprofen as Fiber Coating for Solid Phase Microextraction of Nonsteroidal Anti‐Inflammatory Drugs
Authors: Al‐Furaiji Qasim Chyad Abdulzahra , Darvishnejad Fatemeh , Raoof Jahan Bakhsh , Ghani Milad 
Published: November 2024

ABSTRACTIn this study, in situ electrodeposition of Zn─Al‐layered double hydroxides (Zn─Al‐LDHs) on the surface of pencil graphite substrate were practiced with interlayer modification by ibuprofen. The prepared composite increases the efficiency of the proposed method by increasing the level of interaction between the sorbent and the selected analytes including acetylsalicylic acid and naproxen (NAP) in real sample. Eventually, the extracted target analytes were injected into high‐performance liquid chromatography ultraviolet (HPLC‐UV) for their measurement. The experimental design including PBD and BBD was implemented to obtain the maximize efficiency and optimal condition for extraction of the target analytes. Therefore, in optimal conditions, limits of detection of 0.33–0.64 µg L−1, linear dynamic range (LDR) of 1–100 µg L−1 (with r2 > 0.9934), and limits of quantification (LOQs) of 1.1–2.1 µg L−1 were obtained for target analytes by SPME‐HPLC‐UV. The intra‐day relative standard deviation (RSD%) were found to range in 3.90%–5.30% (4.90%–6.80%) at concentration of 5–50 µg L−1 (2–10 µg L−1). According to obtained result, the relative recovery was calculated between 90% and 109%. Therefore, the obtained results showed that the selected method has a suitable performance for the preconcentration and extraction of acetylsalicylic acid and NAP in biological samples.
Uniform Polymer Microspheres by Photoinduced Metal‐Free Atom Transfer Radical Precipitation Polymerization
Authors: Bicak Tugrul Cem , Liu Huiyin , Haupt Karsten , Gonzato Carlo , Fresnais Jérôme , Ménager Christine , Fensterbank Louis , Ollivier Cyril , Griffete Nébéwia 
Published: November 2024

AbstractHerein, a photoinduced method is introduced for the synthesis of highly cross‐linked and uniform polymer microspheres by atom transfer radical polymerization (ATRP) at room temperature and in the absence of stabilizers or surfactants. Uniform particles are obtained at monomer concentrations as high as 10% (by volume), with polymers being exempt from contamination by residual transition metal catalysts, thereby overcoming the two major longstanding problems associated with thermally initiated ATRP‐mediated precipitation polymerization. Moreover, the obtained particles have also immobilized ATRP initiators on their surface, which directly enables the controlled growth of densely grafted polymer layers with adjustable thickness and a well‐defined chemical composition. The method is then employed successfully for the synthesis of molecularly imprinted polymer microspheres.
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c‐Myc/p27 Signaling Pathway
Authors: Li Jiachen , Wang Yaojie , Wei Sisi , Xu Shi , Dai Suli , Zhang Li , Tian Ziqiang , Zhao Lianmei , Lv Huilai 
Published: November 2024

ABSTRACTNever in mitosis gene A (NIMA)‐related kinase 2 (NEK2) is a crucial serine‐threonine kinase involved in the process of cell mitosis. However, the precise relationship between NEK2 and esophageal squamous cell carcinoma (ESCC) remains inadequately understood. NEK2 expression in ESCC tissues was assessed through bioinformatics analysis, reverse transcription‐quantitative PCR (RT‐qPCR) and immunohistochemistry, revealing a correlation with ESCC patient prognosis. Cultured ESCC cells and human normal esophageal epithelial cells (HEEC) were used to investigate the effects of NEK2 knockdown on the development and progression of ESCC by integrated confluence algorithm, colony formation, wound‐healing, transwell, and ESCC xenograft tumor model, in vitro and in vivo. In ESCC tissues, NEK2 was found to be significantly upregulated, and its expression correlated with poor prognosis in ESCC patients. NEK2 may facilitate ESCC development by regulating cell proliferation, migration, and invasion. Additionally, results from in vivo experiments suggested that NEK2 knockdown can inhibit tumor growth. Moreover, forkhead box M1 (FOXM1) was identified as a potential downstream target of NEK2 in the regulation of ESCC, with its overexpression reversing the effects of NEK2 knockdown on ESCC. Mechanistic studies also indicated that NEK2 may promote the malignant progression of ESCC by inhibiting cellular senescence through the activation of the FOXM1/c‐Myc/p27 signaling pathways, which may provide a novel perspective for the management of ESCC.
Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson's Disease: A Genome‐wide Association Study
Authors: Hwang Yun Su , Jo Sungyang , Lee Seung Hyun , Park Kye Won , Shin Eunsoon , Park YoonGi , Seo Yunji , Kwon Kyum‐Yil , Kim Jae Seung , Jeon Sang Ryong , Lee Jae‐Hong , Chung Sun Ju 
Published: November 2024

AbstractBackgroundThe age at onset (AAO) of Parkinson's disease (PD) varies widely among individuals and significantly influences disease progression and prognosis. However, few genome‐wide association studies (GWASs) have investigated genetic variants determining AAO, particularly in East Asian populations.ObjectivesTo identify single‐nucleotide polymorphisms (SNPs) affecting AAO of PD in Korean patients.MethodsWe conducted a GWAS on AAO of PD in 1048 Korean patients using sex‐adjusted linear regression models. Additionally, we conducted downstream analyses of our primary GWAS results.Resultsrs2134545 demonstrated genome‐wide significance (β = −2.459; standard error [SE] = 0.851; P = 1.898 × 10−8) and is an intergenic SNP near the ALCAM gene associated with an average AAO reduction of 3.47 years. Additionally, rs4366309 (LYST; MIR1537) demonstrated suggestive significance (β = 2.949; SE = 1.072; P = 8.68 × 10−8) and was associated with an average delay of 3.05 years. The polygenic risk score based on known PD risk loci also affected the AAO for European and Korean PD risk loci, respectively (β = −0.149; P < 0.001 and β = −0.096; P = 0.002). However, the proportion of variance was small (r2 = 0.022 and 0.009, respectively).ConclusionWe identified a novel SNP associated with the AAO of PD near the ALCAM gene, distinct from previously reported PD risk loci. These findings need further functional validation; however, they suggest unique genetic pathways influencing the AAO of PD and highlight the need for further research in diverse populations. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.