bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ssb2 is a novel factor in regulating synthesis and degradation of Gcn4 in Saccharomyces cerevisiae
Authors: Jung Youjin , Seong Ki Moon , Baek Je‐Hyun , Kim Joon 
Published: July 2018

SummaryYeast cells respond to environmental stress by inducing the master regulator Gcn4 to control genes involved in biosynthesis of amino acids and purine pathways. Gcn4 is a member of the basic leucine Zipper family and binds directly as a homodimer to a conserved regulatory region of target genes. Ssb2 was discovered to rescue the mutant Gcn4 which has a point mutation that decreases DNA‐binding affinity. Ssb2 is part of the Hsp70 protein family responsible for protein quality control and it is thought that Ssb2 assists the passage of nascent polypeptide chains from the ribosomes. To characterize the mechanism behind the rescue of the mutant gcn4 phenotype, transcriptional activity and protein levels of Gcn4 were analyzed. We found that Ssb2 improved the expression of Gcn4 target genes by increasing the DNA‐binding affinity of gcn4 mutants to target gene promoters under conditions of amino acid starvation. Gcn4 levels increased at both translational and post‐translational levels without regulating GCN4 steady‐state mRNA levels. We also found that the nuclear export signal of Ssb2 is required for interaction with Gcn4 and rescue of the gcn4 mutant phenotype. These findings suggest that Ssb2 is a critical factor that modulates Gcn4 functions in the nucleus and cytosol.
Accessory gland proteins of males in the male‐diphenic ant Cardiocondyla obscurior
Authors: Fuessl Marion , Santos Carolina G. , Hartfelder Klaus , Schrempf Alexandra , Heinze Jürgen 
Published: July 2018

AbstractSeminal fluid proteins are important agents in sperm competition and sexual conflict. In solitary insects, males and females may have different interests concerning the outcome of a mating episode, and males may use seminal fluid to manipulate the physiology and behaviour of the female against the latter's fitness interests. Less is known about the role of seminal fluids in social insects, where the interests of mating partners are more aligned because of life‐long pair‐bonding. In the male‐diphenic ant Cardiocondyla obscurior, mating even with sterilized males appears to prolong the lifespan of queens, suggesting a positive role of seminal fluids. In the present study, using two approaches (two‐dimensional gel electrophoresis/mass spectrometry and representational difference analysis), we analyze the seminal fluid and the male accessory glands of both winged and wingless males of C. obscurior. The results obtained reveal the presence of hundreds of proteins, of which proteases and protease inhibitors are also widespread in the seminal fluids of other insects.
The yin‐yang of the interaction between myelomonocytic cells and NK cells
Authors: Molgora Martina , Supino Domenico , Mavilio Domenico , Santoni Angela , Moretta Lorenzo , Mantovani Alberto , Garlanda Cecilia 
Published: July 2018

AbstractNK cells are innate lymphoid cells, which play a key role in the immune response to cancer and pathogens and participate in the shaping of adaptive immunity. NK cells engage in a complex bidirectional interaction with myelomonocytic cells. In particular, macrophages, dendritic cells and neutrophils promote differentiation and effector function of NK cells and, on the other hand, myelomonocytic cells express triggers of checkpoint blockade (eg PD‐L1) and other immunosuppressive molecules, which negatively regulate NK cell function. In addition, NK cells express high levels of IL‐1R8, which acts as a checkpoint for IL‐18 driven differentiation and activation of NK cells. Evidence suggests that targeting the myeloid cell‐NK cell crosstalk unleashes effective anti‐tumour and anti‐viral resistance.
Voting Turnout and Referendum Outcomes on Same‐Sex Marriage, 1998–2015*
Authors: Simon Christopher A. , Matland Richard E. , Wendell Dane G. , Tatalovich Raymond 
Published: July 2018

ObjectivesThis analysis of referenda voting on same‐sex marriage (SSM) from 1998 until Obergefell v. Hodges (2015) focuses on the impact of turnout, which has been neglected in previous research on gay marriage referenda.MethodsWe employ OLS regression analysis with clustered standard errors by state to analyze voting on SSM referenda with eight county‐level variables and seven state‐level variables. Our novel data set includes 2,610 counties across 34 different states.ResultsHigher referendum turnout consistently produced less support for banning SSM. Additionally, we find that the gap between the polling numbers and referendum results was caused by low turnout levels. A higher turnout would reduce that gap, so that polling would have more closely approximated public opinion.ConclusionsThese findings suggest that impact of voter turnout on public policy is understudied, and including turnout measures may help future researchers better understand the electoral behavior of morality policy referenda.
The Influence of Compression Socks During a Marathon on Exercise-Associated Muscle Damage
Authors: Zaleski Amanda L. , Pescatello Linda S. , Ballard Kevin D. , Panza Gregory A. , Adams William , Hosokawa Yuri , Thompson Paul D. , Taylor Beth A. 
Published: July 2018

Context:Compression socks have become increasingly popular with athletes due to perceived enhancement of exercise performance and recovery. However, research examining the efficacy of compression socks to reduce exercise-associated muscle damage has been equivocal, with few direct measurements of markers of muscle damage.Objective:To examine the influence of compression socks worn during a marathon on creatine kinase (CK) levels.Design:A randomized controlled trial.Setting:2013 Hartford Marathon, Hartford, CT.Participants:Adults (n = 20) randomized to control (CONTROL; n = 10) or compression sock (SOCK; n = 10) groups.Main Outcome Measures:Blood samples were collected 24 hours before, immediately after, and 24 hours following the marathon for the analysis of CK, a marker of muscle damage.Results:Baseline CK levels did not differ between CONTROL (89.3 [41.2] U/L) and SOCK (100.0 [56.2] U/L) (P = .63). Immediately following the marathon (≤1 h), CK increased 273% from baseline (P < .001 for time), with no difference in exercise-induced changes in CK from baseline between CONTROL (+293.9 [278.2] U/L) and SOCK (+233.1 [225.3] U/L;P = .60 for time × group). The day following the marathon (≤24 h), CK further increased 1094% from baseline (P < .001 for time), with no difference in changes in CK from baseline between CONTROL (+ 1191.9 [1194.8] U/L) and SOCK (+889.1 [760.2] U/L;P = .53 for time × group). These similar trends persisted despite controlling for potential covariates such as age, body mass index, and race finishing time (Ps > .29).Conclusions:Compression socks worn during a marathon do not appear to mitigate objectively measured markers of muscle damage immediately following and 24 hours after a marathon.
Polyp detection rate: does length matter?
Authors: Segal Jonathan P , Kanagasundaram Cynthia , Mills Philip , Bassett Paul , Greenfield Simon M 
Published: July 2018

IntroductionPolyp detection rate is a surrogate marker for adenoma detection rate and therefore a surrogate marker of quality colonoscopy. To our knowledge, this is the first study that compares distance from the monitor to the endoscopist on polyp detection rate.MethodsThis was a retrospective study comparing polyp detection rate across two different endoscopy room set-ups. All colonoscopies performed between December 2013 and November 2014 were retrieved. The difference in the room set-up was the distance from the endoscopist to the endoscopy monitor. Room A had a distance of 219 cm and Room B had 147 cm. We used two identical rooms, C and D, as a control arm with a distance of 190 cm between the endoscopist and the monitor.ResultsThere were significant differences in polyp detection rates between Room A and Room B in the bowel cancer screening lists. For these lists, the room with the closest distance from the endoscopist to the monitor (147 cm) had a statistically significant higher polyp detection rate than the room that had a further monitor to endoscopist distance of 219 cm (p<0.0006) and a trend towards a higher polyp detection rate compared with the room where the distance between the monitor and the endoscopist was 190 cm (p=0.08). This effect was not noticed across the service lists.ConclusionsThis study has suggested that the distance from the endoscopist to the monitor can affect polyp detection rate. It appears that for bowel cancer screening lists, the further the endoscopist from the monitor the lower their polyp detection rate.
Medical Martyrs: Nineteenth-Century Representations of Early Modern Inquisitorial Persecution of Spanish Physicians
Authors: Keitt Andrew 
Published: July 2018

Abstract
This essay examines the discourse on medicine and the Inquisition in nineteenth-century Spain. It traces how liberal reformers selectively appropriated aspects of the history of Spanish medicine in the service of their contemporary political and scientific agendas, and how in doing so they contributed to the formation of new professional and national identities.
“Speaking with the Fire”: The Inquisition Confronts Mesoamerican Divination to Treat Child Illness in Sixteenth-Century Guatemala
Authors: Few Martha 
Published: July 2018

Abstract
Indigenous midwives and female healers who treated infants and children in late-sixteenth-century Guatemala were medico-religious specialists who mediated the natural and supernatural realms to treat child illness. Their socially critical roles are examined through the lens of an Inquisition investigation in the tributary Maya town of Samayaq in colonial Central America into indigenous and mixed race women’s use of divination as a strategy to treat child illness, and in particular mollera caída, or fallen fontanel.
A Study of Consumer Behaviour towards Genetically Modified Foods and the Moderating Effects of Health Consciousness
Authors: Singhal Neha 
Published: July 2018

With growing environmentalism and health concerns, people have become more conscious of the types of food they consume and the way they are processed. The principle of the present research paper is to explore the behaviour of consumers towards genetically modified (GM) foods and the moderating role of health consciousness. The rationale behind the present study is to address the gap in the past research work wherein most of the researchers have emphasized on major factors that influence consumption of GM foods such as product acceptance, information, higher income and ethical consumption. Findings This paper explores the effect of consumer’s health consciousness on their GM food purchase. The key purpose of the study is to explore the influence of health consciousness of consumers in moderating consumer attitude towards their behaviour in context of GM food products. The results suggest that information provided by the government and the trusted regulatory help consumers to form positive attitude towards GM foods. Practical implications The findings suggest that the marketer should revolve advertisement and marketing strategies around the issues pertaining consumer’s health consciousness. Moreover, government and other trusted regulatory must ensure consumers that GM food are healthy and superior to conventional food. Originality/value This is one of the primary studies to examine the moderating effect of a health consciousness that bears on GM foods. Its empirical findings are projected to benefit the sustained expansion of GM foods.
Posterior keratoconus—clinical aspects and anterior segment optical coherence tomography findings: A case report
Authors: Vargas Veronica , Alió Jorge 
Published: July 2018

Purpose: To describe a case of Posterior Keratoconus (keratoconus posticus); its clinical condition, corneal, refractive response to intracorneal ring implantation (MyoRing), anterior segment optical coherence tomography findings; and micro incisional cataract surgery outcome. Methods: Case report. Results: The case was studied with high resolution anterior segment optical coherence tomography (OCT), epithelium OCT, corneal topography, and aberrometry. A MyoRing was implanted and after the development of cataract, microincisional cataract surgery was performed. A large hyperopic shift was observed following the ring implantation. Calculation of the intraocular lens showed poor predictability. Conclusions: Posterior keratoconus is a rare corneal congenital disorder characterized by a posterior corneal elevation. Surprisingly, on the total corneal aberrometry, the coma is within normal levels; in the anterior and posterior corneal aberrometry, all the low order and high order aberrations are outside of normal parameters. The epithelial thickness is normal on the contrary to anterior keratoconus. Micro incisional cataract surgery can be safely performed in these eyes, although a refractive surprise is expected due to errors in the intraocular lens calculation.
Gene therapy in hemophilia A: a cost-effectiveness analysis
Authors: Machin Nicoletta , Ragni Margaret V. , Smith Kenneth J. 
Published: July 2018

Key PointsGene therapy is cost-effective in severe hemophilia A compared with standard factor VIII prophylaxis. Over a 10-year time horizon, gene therapy cost $1M and resulted in 8.33 QALYs gained, whereas prophylaxis cost $1.7M and resulted in 6.62 QALYs gained.
Was bewirkt der Einsatz von Spielfilmen im Fremdsprachenunterricht? Die empirische Forschung im Überblick
Authors: Burger Günter 
Published: July 2018

ZusammenfassungDieser Beitrag referiert die Befunde von quantitativen und qualitativen empirischen Studien zum Einsatz von Spielfilmen im Fremdsprachenunterricht. Er basiert auf der Durchsicht von über 160 Arbeiten, die von 1986 bis 2017 publiziert wurden und in denen z. B. untersucht wurde, ob sich die Verwendung von Spielfilmen (ganz oder ausschnittweise) positiv auf die Motivation, die interkulturellen Kompetenzen, den Wortschatz oder das Hörverstehen der Lernenden auswirkt. Die meisten Studien kommen zu dem Ergebnis, dass Spielfilme sehr effektive Lehr- und Lernressourcen sind. Der Artikel macht auch einige Vorschläge für weitere Forschungen zur Verwendung von Spielfilmen, insbesondere für den DaF-Bereich.
The Luwian word for ‘place’ and its cognates
Authors: Yakubovich Ilya 
Published: July 2018

Abstract
Contrary to the common assumption, the Luwian word for ‘place’, hidden under the logogram <LOCUS> in Anatolian hieroglyphic transmission, is genetically unrelated to Hittite pēda- (n.) ‘place’. Based on synchronic combinatory evidence, it can be assigned the phonological interpretation /allV(n)t-/ (n.). Its closest demonstrable cognates are Kizzuwatna Luwian /arlanuwa-i/ ‘to replace, relocate’ and Lydian arlil(i)- ‘belonging to the homestead, household’, which suggests the reconstruction of *arl(a)- ‘place’ at an earlier stage of the Luwian language. The Luwian and Lydian words treated in this paper are likely to be ultimately derived from the Anatolian verbal root ‘to stand’ (cf. Hittite artari ‘stands’). The original meaning of Hittite pēda- was possibly ‘plain’. An additional result of this article consists in the improved understanding of several Luwian and Lydian passages.
Zum Beginn der YALBURT-Inschrift
Authors: Schürr Diether 
Published: July 2018

Zusammenfassung
Verfochten werden eine andere syntaktische Zuordnung von Theonym + wa/i-sa-ti und die Annahme, das /mōwa-/ auch hier und in den Hartapus-Inschriften etwa ‚starken‘ bedeutet. Die Blocke 1, 16 und 10 bildeten zusammen die rechte Halfte der Sudseite, so das die in das Becken hinabfuhrenden Stufen ursprunglich in der Mitte angebracht gewesen sein mussen
An alphabetic parallel for Mycenaean ma-ka
Authors: Pierini Rachele 
Published: July 2018

Abstract
The Mycenaean term ma-ka is recorded on tablets from Thebes, mostly belonging to the Fq series. Even though its interpretation has been broadly investigated, it still lacks a widely shared alphabetic reading. This paper provides a 1st millennium Greek parallel, and such proposal has been made both taking into account previous studies on the subject as well as approaching the whole question from a different point of view. Results emerging from this hypothesis are then used to further clarify certain content aspects of the tablets attesting ma-ka as well as to cast new light on other related controversial issues
Use of Cyclone Dust as Fill Material in Highway Construction
Authors: Raju P. Guru , Verma Amit K. , Kumar Hemant 
Published: July 2018

Abstract
Because good-quality natural resources are depleting fast, there is an urgent need to look for alternative materials, preferably waste material, for road construction. Cyclone dust is a waste material, nonbiodegradable in nature, and is generated during production of hot mix asphalt. The percentage of waste generated varies between 7–10 % by weight of asphalt mix produced based on the type of aggregate used. Generally, 2–3 % of it is reused as filler in asphalt mixes, and approximately 5 % of cyclone dust is left unutilized, which then needs to be disposed of or reused. Planning a proper disposal of cyclone dust is a challenge for the industry. An attempt has been made to assess the suitability of cyclone dust as embankment or subgrade fill material in highway construction. Specimens from different locations across India were collected and tested in line with the requirements given by the Ministry of Road Transport and Highways and the Bureau of Indian Standards. It is observed that the cyclone dust meets the requirements necessary to be used as embankment or subgrade material in highway construction. This material seems to be superior to pond ash in terms of its mechanical properties and ease of use in construction.
Data-Based Nonlinear Model Identification in Economic Model Predictive Control
Authors: Giuliani Laura , Durand Helen 
Published: July 2018

Abstract
Many chemical/petrochemical processes in industry are not completely modeled from a first-principles perspective because of the complexity of the underlying physico-chemical phenomena and the cost of obtaining more accurate, physically relevant models. System identification methods have been utilized successfully for developing empirical, though not necessarily physical, models for advanced model-based control designs such as model predictive control (MPC) for decades. However, a fairly recent development in MPC is economic model predictive control (EMPC), which is an MPC formulated with an economics-based objective function that may operate a process in a dynamic (i.e., off steady-state) fashion, in which case the details of the process model become important for obtaining sufficiently accurate state predictions away from the steady-state, and the physics and chemistry of the process become important for developing meaningful profit-based objective functions and safety-critical constraints. Therefore, methods must be developed for obtaining physically relevant models from data for EMPC design. While the literature regarding developing models from data has rapidly expanded in recent years, many new techniques require a model structure to be assumed a priori, to which the data is then fit. However, from the perspective of developing a physically meaningful model for a chemical process, it is often not obvious what structure to assume for the model, especially considering the often complex nonlinearities characteristic of chemical processes (e.g., in reaction rate laws). In this work, we suggest that the controller itself may facilitate the identification of physically relevant models online from process operating data by forcing the process state to nonroutine operating conditions for short periods of time to obtain data that can aid in selecting model structures believed to have physical significance for the process and, subsequently, identifying their parameters. Specifically, we develop EMPC designs for which the objective function and constraints can be changed for short periods of time to obtain data to aid in model structure selection. For one of the developed designs, we incorporate Lyapunov-based stability constraints that allow closed-loop stability and recursive feasibility to be proven even as the online “experiments” are performed. This new design is applied to a chemical process example to demonstrate its potential to facilitate physics-based model identification without loss of closed-loop stability. This work therefore reverses a question that has been of interest to the control community (i.e., how new techniques for developing models from data can be useful for control of chemical processes) to ask how control may be utilized to impact the use of these techniques for the identification of physically relevant process dynamic models that can aid in improving process operation and control for economic and safety purposes.
Magnetoresistance of Ge-Si Whiskers in the Vicinity to Metal– Insulator Transition
Authors: Druzhinin A.A. , Ostrovskii I.P. , Khoverko Yu.M. , Liakh-Kaguy N.S. 
Published: July 2018

The magnetoresistance of GeхSi1-х (x = 0.002¸ 0.11) whiskers with an acceptor concentration (Na = 3x1018¸ 2.1019 cm-3) near the metal-insulator transition (MIT) was studied at low temperatures (4.2 - 77)K in magnetic fields up to 14 T. It is shown that at 4.2 K the magnetoresistance of the Ge-Si whiskers on thedielectric side of the MIT is quadratic, while the magnetoresistance of the crystals on the metal side of the MIThas an exponential dependence on the magnetic field. In the samples in the immediate vicinity to the MIT on thedielectric side, negative magnetoresistance was detected, whereas in metal samples with a high germaniumcontent (x = 11 at.%) an anomalous positive magnetoresistance occurs. The resulting anomalous dependences arerespectively explained by the conductivity with respect to the delocalized A+ states of the upper Hubbard bandand the increase in the electron-electron interaction in Ge-Si whiskers at increasing germanium content.
Investigation of Mechanisms of Potassium and Cesium-137 Uptake by Plants with Optical and Gamma Spectrometries in the Field under Water-Stressed Conditions
Authors: Prorok V. V. , Dacenko O. I. , Bulavin L. A. , Zelensky S. E. , Poperenko L. V. 
Published: July 2018

Channels of the 137Cs and potassium transfer from soil to plants in the field under water-stressed conditions are investigated. Different rapidly maturing plants were grown and selected simultaneously several times during the 2012 and 2013 seasons at the same experimental sites with different soil types under natural conditions at the Chornobyl 10-km Exclusion Zone. After each selection, the contents of 137Cs and K in the plants and extracted soil solutions were measured. Potassium and cesium entered plant roots, as a rule, through transporters with low selectivity, when the concentration of dissolved potassium (CK) in soil was greater than 2 /ug/cm3. In this case, the selectivity of the plant uptake for 137Cs versus potassium r was near 1. However, when CK was between 0.5 and 2 /ug/cm3, potassium also appeared to enter plant roots through highly selective potassium transporters, while cesium entered roots only through the transporters with low selectivity. In this case, the value of r was much less than 1. When CK was less than 0.5 /ug/cm3, cesium and potassium appeared to enter roots through a complement of transporters with greater selectivity for cesium than for potassium. The value of r in this case could exceed 1.