bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left ventricular peak early diastolic strain rate detected by two‐dimensional speckle tracking echocardiography and disease severity in pre‐capillary pulmonary hypertension
Authors: Liu Bing‐yang , Wu Wei‐chun , Zeng Qi‐xian , Liu Zhi‐hong , Niu Li‐li , Tian Yue , Cheng Xiao‐ling , Luo Qin , Zhao Zhi‐hui , An Chen‐hong , Huang Li , Wang Hao , He Jian‐guo , Xiong Chang‐ming 
Published: July 2019

We investigated and compared the correlations between two‐dimensional speckle tracking echocardiography detected left ventricular peak early diastolic strain rates (global: left ventricular global peak early diastolic strain rate; septum: left ventricular peak early diastolic strain rate of septum; free wall: left ventricular peak early diastolic strain rate of free wall) and disease severity in pre‐capillary pulmonary hypertension. Seventy‐four pre‐capillary pulmonary hypertension patients (23 males and 51 females, 35 ± 13 years) and thirty healthy controls were consecutively recruited for two‐dimensional speckle tracking echocardiography analyses in our study. Medical records of pre‐capillary pulmonary hypertension patients were reviewed to capture clinical data; risk assessments were performed based on the 2015 ESC Guidelines. Compared with healthy controls, left ventricular global peak early diastolic strain rate was lower in pre‐capillary pulmonary hypertension patients (1.11 ± 0.60 s−1 versus 1.47 ± 0.45 s−1, P = 0.001), especially that of the septum (1.13 ± 0.58 s−1 versus 1.68 ± 0.46 s−1, P<0.001). Linear correlation analyses showed significant but weak correlations between left ventricle diastolic parameters and peak oxygen consumption, N‐terminal pro‐brain natriuretic peptide, and conventional echocardiographic right ventricle parameters: E/E′, tricuspid annular plane systolic excursion, S′, and fractional area change. No or weak correlations were observed between left ventricle diastolic parameters and hemodynamics. Multivariate logistic regression analyses showed left ventricular global peak early diastolic strain rate (OR: 0.304; 95%CI: 0.101–0.911) and left ventricular peak early diastolic strain rate of septum (OR: 0.252; 95%CI: 0.075–0.848) independently predict intermediate–high risk of pulmonary hypertension patients, even adjusted by age, gender, and body mass index. Receive operating characteristic curves showed that all the three models had the capacity to predict intermediate–high risk of pulmonary hypertension patients, and the model including left ventricular peak early diastolic strain rate of septum showed the strongest predictive capacity (area under the curve = 0.76, 95%CI: 0.59–0.93). Two‐dimensional speckle tracking echocardiography detected left ventricle diastolic function parameters are significantly correlated with clinical data and can independently predict intermediate–high risk in pre‐capillary pulmonary hypertension patients; the dysfunction of interventricular septum may make major contribution.
Fluorescein Angiography of Persistent Incomplete Vascularization of the Retina After Bevacizumab Therapy in Retinopathy of Prematurity
Authors: Lin Xihui , Patel Sagar B. , Zhang Alice Y. , Brill Daniel A. , Le Kim H. , He Yu-Guang 
Published: July 2019

Purpose: This study evaluates the vascular development of premature infants at 50 weeks postconception after treatment with intravitreal bevacizumab for type 1 retinopathy of prematurity (ROP). Methods: A retrospective case series was conducted on type 1 ROP neonates with a high risk of general anesthesia complications. Patients were treated with bevacizumab between February 2013 and February 2016. At 50 weeks’ gestational age, all patients were imaged with RetCam (Clarity Medical Systems, Inc) fundus photographs and widefield fluorescein angiography (FA). Results: There were 4 boys and 7 girls with an average gestational age of 24.8 weeks and weight of 734.3 grams at birth. The estimated gestational age at injection was 37.1 weeks. Examination under anesthesia with FA was performed at a mean of 61 weeks posttreatment. Nineteen of 20 eyes (95%) of 11 infants had incomplete vascularization and peripheral nonperfusion on imaging. FA showed new vessels with increased tortuosity, microvascular abnormalities, and leakage past the original ridge. These 19 patients were treated with confluent ablative photocoagulation to the peripheral nonperfused retina. Patients were followed for a mean of 73.3 weeks after birth. None required incisional surgery. Conclusions: Patients with type 1 ROP treated with bevacizumab may have delayed vascularization of the peripheral retina and even late recurrence of active disease. Clinicians should regularly monitor patients after bevacizumab for potential neovascular complications.
Transient and chronic childhood immune thrombocytopenia are distinctly affected by Fc-γ receptor polymorphisms
Authors: Schmidt David E. , Heitink-Pollé Katja M. J. , Laarhoven Annemieke G. , Bruin Marrie C. A. , Veldhuisen Barbera , Nagelkerke Sietse Q. , Kuijpers Taco W. , Porcelijn Leendert , van der Schoot C. Ellen , Vidarsson Gestur , de Haas Masja 
Published: July 2019

AbstractIn childhood immune thrombocytopenia (ITP), anti-platelet autoantibodies mediate platelet clearance through Fc-γ receptor (FcγR)–bearing phagocytes. In 75% to 90% of patients, the disease has a transient, self-limiting character. Here we characterized how polymorphisms of FcγR genes affect disease susceptibility, response to intravenous immunoglobulin (IVIg) treatment, and long-term recovery from childhood ITP. Genotyping of the FCGR2/3 locus was performed in 180 children with newly diagnosed ITP, 22 children with chronic ITP, and 180 healthy control children by multiplex ligation-dependent probe amplification. Children with newly diagnosed ITP were randomly assigned to a single administration of IVIg or observation, and followed for 1 year (Treatment With or Without IVIg for Kids With ITP [TIKI] trial). We defined transient ITP as a complete recovery (≥100 × 109/L) 3 months after diagnosis, including both self-limiting disease/IVIg responders and chronic ITP as absence of a complete recovery at 12 months. ITP susceptibility, as well as spontaneous recovery and response to IVIg, was associated with the genetic variants FCGR2C*ORF and FCGR2A*27W and the FCGR2B promoter variant 2B.4. These variants were overrepresented in patients with transient (N = 131), but not chronic (N = 43), disease. The presence of FCGR2C*ORF predisposed to transient ITP with an odds ratio of 4.7 (95% confidence interval, 1.9-14.3). Chronic ITP was associated with a deletion of FCGR2C/FCGR3B (copy number region 1) with an odds ratio of 6.2 (95% confidence interval, 1.8-24.7). Taken together, susceptibility to transient and chronic ITP is distinctly affected by polymorphic variants of FCGR2/3 genes. Our data suggest that genotyping of the FCGR2/3 locus may be useful for prognosis and guidance of treatment decisions in newly diagnosed childhood ITP.
The relationship between psychosocial risk factors, burnout and quality of life among primary healthcare workers in rural Guangdong province: a cross-sectional study
Authors: Asante Joseph Obiri , Li Meng Jie , Liao Jing , Huang Yi Xiang , Hao Yuan Tao 
Published: July 2019

Abstract

Background
Healthcare workers are often exposed to stressful working conditions at work which affect their quality of life. The study investigated the relationship between psychosocial risk factors, stress, burnout, and quality of life among primary healthcare workers in general medical practice in Qingyuan and Chaozhou cities in Guangdong province.

Method
The cross-sectional study was conducted in 108 primary health facilities including 36 community health centers (CHCs) across two developing cities in Guangdong province. A total of 873 healthcare workers completed the questionnaires. Quality of life was evaluated using The World Health Organization Quality of Life Questionnaire (WHOQOL-BREF) and psychological risk factors were evaluated by the Copenhagen Psychosocial Questionnaire (COPSOQ). General quality of life and the quality of life domains were transformed into a score range from minimum 0 to 100 maximum. Higher scores indicated better quality of life and vice versa. Significant associations were verified using multiple regression analysis.

Results
Poor quality of life was observed in 74.6% of healthcare workers surveyed. General poor quality of life was significantly higher among workers who reported higher burnout (Beta = − 0.331, p < 0.001). In addition, workers with high levels of burnout, unmarried workers and female workers had a higher possibility of physical health. A greater risk of poor psychological health was observed among workers with high burnout, poor sense of community and those with lower educational levels. Workers who lacked social support, those with fewer possibilities for development had increased probability of poor quality of life in the social domain. Poor quality of life in the environmental domain was observed among workers who were dissatisfied with their jobs and workers with low salaries.

Conclusions
Primary healthcare workers in developing cities in China have a highly demanding and strained working environment and poor quality of life. Reducing job stress and improving work conditions may ultimately improve the well-being of primary healthcare workers.
Pediatric Oncology in Nigeria: A Panoramic View
Authors: Akinsete Adeseye Michael , Odugbemi Babatunde Adeniran , Ogundowole Gbemisola Eniola , Anene-Nzelu Uchechukwu Udochukwu , Temiye Edamisan , Akinsulie Adebola 
Published: July 2019

PURPOSE A large number of children still die as a result of cancer in low- to middle-income countries, and factors such has poor infrastructure, inadequate human resources, and poorly developed health insurance are responsible for most of these deaths. Nigeria is a country with a young population and a struggling health system. We aimed to survey pediatric oncologists in Nigeria using an online survey instrument. METHODS We surveyed the national group of pediatric oncologists using an instrument designed to assess manpower availability, infrastructural support, support services, and presence of radiotherapy and medications. RESULTS A total of 14 institutions responded, represented by 24 oncologists of the 42 oncologists on the platform, with a response rate of 57.1%. Most of the oncologists had practiced for more than 10 years, but only two institutions had a dedicated pediatric oncology ward. There was no population-based pediatric oncology tumor registry. Molecular diagnostic capability was not available, nor was a structurally efficient radiotherapy support service. The centers also struggled with inadequate blood and blood product provision. CONCLUSION Pediatric oncology services in Nigeria are still grappling with weak human capital, poorly developed infrastructure, weak regional and national referral systems, and poor support services.
Nationally Representative Estimates of Serum Testosterone Concentration in Never-Smoking, Lean Men Without Aging-Associated Comorbidities
Authors: Platz Elizabeth A , Barber John R , Chadid Susan , Lu Jiayun , Dobs Adrian S , Kanarek Norma F , Nelson William G , Bradwin Gary , McGlynn Katherine A , Rohrmann Sabine 
Published: July 2019

Abstract

Context
Testosterone deficiency prevalence increases with age, comorbidities, and obesity.

Objective
To inform clinical guidelines for testosterone deficiency management and development of targets for nonpharmacologic intervention trials for these men, we determined serum testosterone in never-smoking, lean men without select comorbidities in nationally representative surveys.

Design, Setting, Participants
We used cross-sectional data for never-smoking, lean men ≥20 years without diabetes, myocardial infarction, congestive heart failure, stroke, or cancer, without use of hormone-influencing medications, and participated in morning sessions of National Health and Nutrition Examination Survey (NHANES) III (phase I 1988–1991) or continuous NHANES (1999–2004). By age, we determined median total testosterone (ng/mL) measured previously by a Food and Drug Administration-approved immunoassay and median estimated free testosterone concentration.

Results
In NHANES III, in never-smoking, lean men without comorbidities, median (25th, 75th percentile) testosterone was 4% to 9% higher than all men—20 to 39 years: 6.24 (5.16, 7.51), 40 to 59: 5.37 (3.83, 6.49), and ≥60: 4.61 (4.01, 5.18). In continuous NHANES, in never-smoking, lean men without comorbidities, levels were 13% to 24% higher than all men—20 to 39 years: 6.26 (5.32, 7.27), 40 to 59: 5.86 (4.91, 6.55), and ≥60: 4.22 (3.74, 5.73). In never-smoking, lean men without comorbidities, median estimated free testosterone was similar to (NHANES III) or slightly higher than (continuous NHANES) in all men.

Conclusions
These nationally representative data document testosterone levels (immunoassay) in never-smoking, lean men without select comorbidities 30 and 15 to 20 years ago. This information can be incorporated into guidelines for testosterone deficiency management and used to develop targets for nonpharmacologic intervention trials for testosterone deficiency.
ΔΕΞΙΟΤΗΤΕΣ ΣΥΜΒΟΥΛΕΥΤΙΚΗΣ «ΑΝΤΙΔΟΤΟ» ΣΤΗΝ ΚΡΙΣΗ
Authors: Κατσικονούρη (Efrosyni Katsikonouri) Ευφροσύνη , Μανίτσα Ευθυμία 
Published: July 2019

Σήμερα όπου και να στρέψεις το κεφάλι σου ακούς τη λέξη ΚΡΙΣΗ. Κρίση οικονομική, κρίση σχέσεων, οικογενειακή κρίση, κρίση πένθους, πολιτική κρίση, κλπ. Το ερώτημα που τίθεται είναι: Υπάρχει κρίση; Και αν ναι, μπορεί να ιαθεί αυτή η «ασθένεια»; Την απάντηση δίνει η συμβουλευτική, που ως επιστήμη εξελίχθηκε κατά τη διάρκεια του εικοστού αιώνα, εστιάζοντας σε πολλούς τομείς, συνδυάζοντας μεθόδους και σχολές. Η παρούσα έρευνα έχει ως σκοπό να διερευνήσει τα προβλήματα που αντιμετωπίζουν τα παιδιά της προσχολικής ηλικίας (4-6 ετών) μέσα από της διαφορετικής μορφής κρίσεις που βιώνουν αλλά και να «απαντήσει» στον τρόπο αντιμετώπισής τους. Το δείγμα αποτέλεσαν 63 γονείς μαθητών δημόσιων νηπιαγωγείων της Αθήνας το δεύτερο εξάμηνο του 2013 και χρησιμοποιήθηκε δομημένο ερωτηματολόγιο με ερωτήσεις κλειστού τύπου. Τα αποτελέσματα έδειξαν ότι παρόλο που στις περισσότερες περιπτώσεις οι γονείς δεν συζητούν μπροστά στα παιδιά τους προβλήματα που αντιμετωπίζουν, ωστόσο παραδέχονται ότι η κρίση επηρεάζει τη ρουτίνα της οικογένειάς τους σε μεγάλο βαθμό, σε μικρότερο τη συμπεριφορά και λιγότερο την ψυχική και σωματική υγεία των παιδιών τους. Πολύ υψηλό ποσοστό κατέχει η πεποίθηση ότι το σχολείο μπορεί να στηρίξει τα παιδιά σε δύσκολες περιόδους. Η έρευνα αναδεικνύει τον συμβουλευτικό και υποστηρικτικό ρόλο του σχολείου και του εκπαιδευτικού στην αντιμετώπιση της «κρίσης».
ΠΡΟΣΕΓΓΙΣΕΙΣ ΤΗΣ ΠΡΟΣΩΠΙΚΗΣ - ΚΟΙΝΩΝΙΚΗΣ ΑΝΑΠΤΥΞΗΣ ΣΤΟ ΠΛΑΙΣΙΟ ΤΟΥ ΝΕΟΥ ΠΡΟΓΡΑΜΜΑΤΟΣ ΣΠΟΥΔΩΝ ΠΡΟΣΧΟΛΙΚΗΣ ΑΓΩΓΗΣ
Authors: Κοντοπούλου (Malanthia Kontopoulou) Μελανθία , Βελλοπούλου Αγγελική , Καμπεζά Mαρία , Παναγιώτου Βασιλική , Ψυχίδου Παρθένα , Μπιρμπίλη Μαρία , Παπανδρέου Μαρία 
Published: July 2019

Στο νέο πρόγραμμα σπουδών για το Νηπιαγωγείο, η προσωπική-κοινωνική ανάπτυξη αποτελεί μια αυτόνομη «μαθησιακή περιοχή» με σαφείς κι επικεντρωμένους μαθησιακούς στόχους και αντίστοιχες προτάσεις για στοχευόμενες δράσεις. Ωστόσο ιδιαίτερη βαρύτητα δόθηκε στη διάχυση των στόχων αυτών στο σύνολο του προγράμματος και στην προώθησή τους παράλληλα με στόχους άλλων γνωστικών αντικειμένων και με βασικές αρχές του προγράμματος. Στην εργασία αυτή, με παράδειγμα τη διαμόρφωση της προσωπικής ταυτότητας, που αποτελεί μια από τις ενότητες της ΠΚΑ, παρουσιάζεται ο τρόπος με τον οποίο αυτή μπορεί να προωθηθεί παράλληλα με στόχους και δραστηριότητες των Φυσικών Επιστημών, των ΤΠΕ, των Κοινωνικών Επιστημών και να συνδεθεί με την εφαρμογή της Διαφοροποιημένης Παιδαγωγικής.
Η συνεισφορά του εκπαιδευτικού υλικού στην επίλυση προβλημάτων πρόσθεσης και αφαίρεσης στο νηπιαγωγείο
Authors: Ζαχάρος (Kostas Zacharos) Κώστας , Παπαδημητρίου (Konstantina Papadimitriou Κωνσταντίνα 
Published: July 2019

Σκοπός της έρευνας που παρουσιάζεται εδώ ήταν να διερευνήσει τις δυνατότητες μαθητών προσχολικής εκπαίδευσης να επιλύουν απλά προβλήματα πρόσθεσης και αφαίρεσης, καθώς και τη συνεισφορά των εξωτερικών αναπαραστάσεων στην επίλυσή τους. Το δείγμα της έρευνας ήταν 12 νήπια ενός δημόσιου νηπιαγωγείου. Στη διαδικασία συλλογής των εμπειρικών δεδομένων χρησιμοποιήθηκαν δυάδες μαθητών που με τη χρήση ζυγαριάς (παλάντζας) και την ισορρόπησή της, δημιουργούν σενάρια που απαιτούν προσθέσεις και αφαιρέσεις μικρών ποσοτήτων. Τα αποτελέσματα της έρευνας δείχνουν ότι η διδασκαλία συνεισφέρει στην επιτυχή αντιμετώπιση των προβλημάτων πρόσθεσης και αφαίρεσης που προτάθηκαν και επιπλέον, η χρήση των αναπαραστάσεων είναι ενισχυτική αυτής της προσπάθειας.
Το παραμύθι ως μέσο εξοικείωσης τον παιδιού με την έννοια του θανάτου: Συναισθηματικές αντιδράσεις μαθητών από αστικές και αγροτικές περιοχές.
Authors: Νικολακοπούλου (Aggeliki Nikolakopoulou) Αγγελική , Ζαφειροπούλου (Maria Zafiropoulou) Μαρία 
Published: July 2019

Η παρούσα έρευνα είχε ως στόχο να μελετήσει και να συγκρίνει τα συναισθήματα μαθητών από αστικές και αγροτικές περιοχές, μετά την αφήγηση έντεχνου και λαϊκού παραμυθιού, το οποίο πραγματεύεται την απώλεια προσφιλούς ύπαρξης. Το δείγμα αποτελείτο από 130 μαθητές, ηλικίας 8 ετών και εξετάστηκαν τα συναισθήματα της χαράς, της λύπης, του θυμού, του άγχους και της ζωντάνιας. Από την ανάλυση των αποτελεσμάτων προέκυψε, ότι η αφήγηση τόσο έντεχνου, όσο και λαϊκού παραμυθιού με θέμα το θάνατο ανθρώπου, επηρεάζει εξίσου τα συναισθήματα των παιδιών της πόλης και των παιδιών του χωριού. Αντίθετα η σύγκριση των ομάδων των παιδιών από αστικές περιοχές και των παιδιών από αγροτικές, μετά την αφήγηση παραμυθιού με θέμα το θάνατο ζώου, έδειξε μεγαλύτερη συναισθηματική φόρτιση στα παιδιά της πόλης.
Research of IT Projects Portfolio Management Models in Cosmetics Retailer
Authors: Денисова Дарья , Denisova Dar'ya 
Published: July 2019

Nowadays there is a large number of studies in the literature devoted to the analysis and classification of approaches to the formation of IT project portfolios. However, the unexamined question remains concerning the effectiveness of IT project portfolios management in the retail sector. Objective: exploration of the existing IT project portfolios management models in the cosmetics retailer, and formulation of recommendations for their improvement, which will help to resolve resource conflicts, to take into account the seasonality in the formation of the portfolios and will increase the overall competitiveness of the company. Object of research: cosmetics retailer. Subject of research: the processes of IT project portfolios management in cosmetics retailer (in particular, the processes of portfolio formation, resource management and quality of project products, as well as success factors of IT-projects).
Research methodology:
1) analysis of the literature;
2) questionnaire;
3) informal interviews with project and portfolio managers;
4) classification and systematization of the information received;
5) analysis of project documentation.
Main results of the study.
1. Identification and classification of IT project portfolios management models in the company, formed independently – flexible model and rigid model.
2. Identification and classification of the factors affecting the quality of it project products in the portfolios. 3. Confirmed the influence of the seasonality factor on the success of projects in the portfolios; the economic efficiency of taking into account the seasonality factor at the stage of formation of the project portfolio is calculated. 4. Recommendations on overcoming of the identified problems in the IT project portfolios management are formulated.
Antibiotic-loaded tantalum may serve as an antimicrobial delivery agent
Authors: Sautet P. , Parratte S. , Mékidèche T. , Abdel M. P. , Flécher X. , Argenson J-N. , Ollivier M. 
Published: June 2019

AimsThe aims of this study were to compare the mean duration of antibiotic release and the mean zone of inhibition between vancomycin-loaded porous tantalum cylinders and antibiotic-loaded bone cement at intervals, and to evaluate potential intrinsic antimicrobial properties of tantalum in an in vitro medium environment against methicillin-sensitive Staphylococcus aureus (MSSA).Materials and MethodsTen porous tantalum cylinders and ten cylinders of cement were used. The tantalum cylinders were impregnated with vancomycin, which was also added during preparation of the cylinders of cement. The cylinders were then placed on agar plates inoculated with MSSA. The diameter of the inhibition zone was measured each day, and the cylinders were transferred to a new inoculated plate. Inhibition zones were measured with a Vernier caliper and using an automated computed evaluation, and the intra- and interobserver reproducibility were measured. The mean inhibition zones between the two groups were compared with Wilcoxon’s test.ResultsMSSA was inhibited for 12 days by the tantalum cylinders and for nine days by the cement cylinders. At day one, the mean zone of inhibition was 28.6 mm for the tantalum and 19.8 mm for the cement group (p < 0.001). At day ten, the mean zone of inhibition was 3.8 mm for the tantalum and 0 mm for the cement group (p < 0.001). The porous tantalum cylinders soaked only with phosphate buffered solution showed no zone of inhibition.ConclusionCompared with cement, tantalum could release antibiotics for longer. Further studies should assess the advantages of using antibiotic-loaded porous tantalum implants at revision arthroplasty. Cite this article: Bone Joint J 2019;101-B:848–851.
Vascular endothelial growth factor pathway promotes osseointegration and CD31hiEMCNhi endothelium expansion in a mouse tibial implant model
Authors: Ji G. , Xu R. , Niu Y. , Li N. , Ivashkiv L. , Bostrom M. P. G. , Greenblatt M. B. , Yang X. 
Published: June 2019

Aims It is increasingly appreciated that coordinated regulation of angiogenesis and osteogenesis is needed for bone formation. How this regulation is achieved during peri-implant bone healing, such as osseointegration, is largely unclear. This study examined the relationship between angiogenesis and osteogenesis in a unique model of osseointegration of a mouse tibial implant by pharmacologically blocking the vascular endothelial growth factor (VEGF) pathway. Materials and Methods An implant was inserted into the right tibia of 16-week-old female C57BL/6 mice (n = 38). Mice received anti-VEGF receptor-1 (VEGFR-1) antibody (25 mg/kg) and VEGF receptor-2 (VEGFR-2) antibody (25 mg/kg; n = 19) or an isotype control antibody (n = 19). Flow cytometric (n = 4/group) and immunofluorescent (n = 3/group) analyses were performed at two weeks post-implantation to detect the distribution and density of CD31hiEMCNhi endothelium. RNA sequencing analysis was performed using sorted CD31hiEMCNhi endothelial cells (n = 2/group). Osteoblast lineage cells expressing osterix (OSX) and osteopontin (OPN) were also detected with immunofluorescence. Mechanical pull-out testing (n = 12/group) was used at four weeks post-implantation to determine the strength of the bone-implant interface. After pull-out testing, the tissue attached to the implant surface was harvested. Whole mount immunofluorescent staining of OSX and OPN was performed to determine the amount of osteoblast lineage cells. Results Flow cytometry revealed that anti-VEGFR treatment decreased CD31hiEMCNhi vascular endothelium in the peri-implant bone versus controls at two weeks post-implantation. This was confirmed by the decrease of CD31 and endomucin (EMCN) double-positive cells detected with immunofluorescence. In addition, treated mice had more OPN-positive cells in both peri-implant bone and tissue on the implant surface at two weeks and four weeks, respectively. More OSX-positive cells were present in peri-implant bone at two weeks. More importantly, anti-VEGFR treatment decreased the maximum load of pull-out testing compared with the control. Conclusion VEGF pathway controls the coupling of angiogenesis and osteogenesis in orthopaedic implant osseointegration by affecting the formation of CD31hiEMCNhi endothelium. Cite this article: Bone Joint J 2019;101-B(7 Supple C):108–114.