bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome Features and Biochemical Characteristics of a Robust, Fast Growing and Naturally Transformable Cyanobacterium Synechococcus elongatus PCC 11801 Isolated from India
Authors: Jaiswal Damini , Sengupta Annesha , Sohoni Sujata , Sengupta Shinjinee , Phadnavis Ambarish G. , Pakrasi Himadri B. , Wangikar Pramod P. 
Published: November 2018

AbstractCyanobacteria provide an interesting platform for biotechnological applications due to their efficient photoautotrophic growth, amenability to genetic engineering and the ability to grow on non-arable land. An ideal industrial strain of cyanobacteria would need to be fast growing and tolerant to high levels of temperature, light, carbon dioxide, salt and be naturally transformable. In this study, we report Synechococcus elongatus PCC 11801, a strain isolated from India that fulfills these requirements. The physiological and biochemical characteristics of PCC 11801 under carbon and light-limiting conditions were investigated. PCC 11801 shows a doubling time of 2.3 h, that is the fastest growth for any cyanobacteria reported so far under ambient CO2 conditions. Genome sequence of PCC 11801 shows genome identity of ~83% with its closest neighbors Synechococcus elongatus PCC 7942 and Synechococcus elongatus UTEX 2973. The unique attributes of PCC 11801 genome are discussed in light of the physiological characteristics that are needed in an industrial strain. The genome of PCC 11801 shows several genes that do not have homologs in neighbor strains PCC 7942 and UTEX 2973, some of which may be responsible for adaptation to various abiotic stresses. The remarkably fast growth rate of PCC 11801 coupled with its robustness and ease of genetic transformation makes it an ideal candidate for the photosynthetic production of fuels and chemicals.
Energetics and Electronic Structure of Triangular Hexagonal Boron Nitride Nanoflakes
Authors: Maruyama Mina , Okada Susumu 
Published: November 2018

AbstractWe studied the energetics and electronic structures of hexagonal boron nitrogen (h-BN) nanoflakes with hydrogenated edges and triangular shapes with respect to the edge atom species. Our calculations clarified that the hydrogenated h-BN nanoflakes with a triangular shape prefer the N edges rather than B edges irrespective of the flake size. The electronic structure of hydrogenated h-BN nanoflakes depends on the edge atom species and their flake size. The energy gap between the lowest unoccupied (LU) and the highest occupied (HO) states of the nanoflakes with N edges is narrower than that of the nanoflakes with B edges and the band gap of h-BN. The nanoflakes possess peculiar non-bonding states around their HO and LU states for the N and B edges, respectively, which cause spin polarization under hole or electron doping, depending on the edge atom species.
Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway
Authors: Upadhyay Rashmi , Sanchez-Hidalgo Andrea , Wilusz Carol J. , Lenaerts Anne J. , Arab Jennifer , Yeh Joanna , Stefanisko Karen , Tarasova Nadya I. , Gonzalez-Juarrero Mercedes 
Published: November 2018

AbstractHere we demonstrate that aerosols of host directed therapies [HDT] administered during a chronic Mycobacterium tuberculosis (Mtb) infection have bactericidal effect. The pulmonary bacterial load of C57BL/6 mice chronically infected with Mtb was reduced by 1.7 and 0.6 log10CFU after two weeks of treatment via aerosol delivery with ST3-H2A2, [a selective peptide inhibitor of the STAT3 N-terminal domain] or IL10R1-7 [selective peptide inhibitor for the IL-10Ra] respectively and when compared to control mice treated with IL10R1-14 [peptide inhibitor used as negative control] or untreated mice infected with Mtb. Accordingly, when compared to control mice, the bactericidal capacity in mice was enhanced upon treatment with peptide inhibitors ST3-H2A2 and IL10R1-7 as evidenced by higher pulmonary activities of nitric oxide synthase, NADPH oxidase and lysozyme enzymes and decreased arginase enzyme activity. This therapy also modulated important checkpoints [Bcl2, Beclin-1, Atg 5, bax] in the apoptosis-autophagy pathways. Thus, even in the absence of antibiotics, targeting of the host pulmonary IL-10-STAT3 pathway can significantly reduce the Mtb bacilli load in the lungs, modulate the host own bactericidal capacity and apoptosis and autophagy pathways. Our approach here also allows targeting checkpoints of the lungs to determine their specific contribution in pulmonary immunity or pathogenesis.
Behavioural responses to unexpected changes in reward quality
Authors: Riemer Stefanie , Thompson Hannah , Burman Oliver H. P. 
Published: November 2018

AbstractSuccessive negative contrast (SNC) effects are changes in anticipatory or consummatory behaviour when animals unexpectedly receive a lower value reward than they have received previously. SNC effects are often assumed to reflect frustration and appear to be influenced by background affective state. However, alternative explanations of SNC, such as the functional-search hypothesis, do not necessarily imply an aversive affective state. We tested 18 dogs in a SNC paradigm using a patch foraging task. Dogs were tested in two conditions, once with the low value reward in all of five trials (unshifted) and once when reward value was altered between high and low (shifted). Following a reward downshift, subjects showed a SNC effect by switching significantly more often between patches compared to the unshifted condition. However, approach latency, foraging time and quantity consumed did not differ between conditions, suggesting non-affective functional search behaviour rather than frustration. There was no relationship between strength of SNC and anxiety-related behaviours as measured in a novel object test and a personality questionnaire (C-BARQ). However, associations with the C-BARQ scores for Trainability and Stranger directed aggression suggest a possible link with behavioural flexibility and coping style. While reward quality clearly affects incentive motivation, the relationship between SNC, frustration and background affective state requires further exploration.
Ultrathin Air-Stable n-Type Organic Phototransistor Array for Conformal Optoelectronics
Authors: Liu Meiling , Wang Haiting , Tang Qingxin , Zhao Xiaoli , Tong Yanhong , Liu Yichun 
Published: November 2018

AbstractDevelopment of conformal n-channel organic phototransistor (OPT) array is urgent for future applications of organic complementary circuits in portable and wearable electronics and optoelectronics. In this work, the ultrathin conformal OPT array based on air-stable n-type PTCDI-C13H27 was fabricated. The OPT array shows excellent electrical and photoelectrical performance, good device uniformity, and remains stable in electron mobility by 83% after 90 days compared to the initial values. Eventhough mobility, on-state current, off-state current, and photocurrent of PTCDI-C13H27 thin film phototransistor show slight decrease with the decreased bending radius, the device still remains the stable photosensitivity as high as 104 when the device is freely adhered on the 2D surfaces and 3D hemispherical sphere, which is in a class with the highest photosensitivity for perylene diimide derivatives. These results present the promising application potential of our conformable air-stable n-type PTCDI-C13H27 OPTs as the photodetection system of curved artificial compound eyes in wearable and portable electronics and optoelectronics.
Leukocyte telomere length and risk of coronary heart disease and stroke mortality: prospective evidence from a Russian cohort
Authors: Stefler Denes , Malyutina Sofia , Maximov Vladimir , Orlov Pavel , Ivanoschuk Dinara , Nikitin Yury , Gafarov Valery , Ryabikov Andrey , Voevoda Mikhail , Bobak Martin , Holmes Michael V 
Published: November 2018

AbstractPrevious studies suggest that reduced leukocyte telomere length (LTL) is related to higher risk of mortality and several chronic conditions, including coronary heart disease (CHD) and stroke. However, the consistency of this association differs across populations. We investigated the relationship of LTL with CHD, stroke and all-cause mortality together with non-fatal CHD and stroke events in a Russian cohort with a mean age of 58 years at baseline. Data from 1,144 individuals in the Russian subset of the Health Alcohol and Psychosocial Factors in Eastern Europe (HAPIEE) cohort study were used. The associations between LTL at baseline and fatal/non-fatal outcomes during 12 years of follow-up were assessed using multivariable Cox regression models, which yielded adjusted hazard ratios (HR). Compared to individuals in the shortest tertile, those in the longest tertile of LTL had a 42% lower risk of death from all-causes (HR 0.58; 95% CI: 0.39–0.88) and 58% lower risk of death from CHD (HR 0.42; 95%CI: 0.19–0.97). Similar patterns of association were identified for non-fatal and combined fatal/non-fatal CHD and stroke events but the associations were weaker. Consistent with results of previous studies in Western populations, this cohort of elderly Russian adults found an inverse association between LTL and CHD and all-cause mortality. These findings reinforce the hypothesis that LTL may play (or be a marker of) an aetiological role in human health across diverse populations.
Mammalian Susceptibility to a Neonicotinoid Insecticide after Fetal and Early Postnatal Exposure
Authors: Burke Andrew P. , Niibori Yosuke , Terayama Hayato , Ito Masatoshi , Pidgeon Charlotte , Arsenault Jason , Camarero Pablo R. , Cummins Carolyn L. , Mateo Rafael , Sakabe Kou , Hampson David R. 
Published: November 2018

AbstractNeonicotinoids have become the most widely used class of insecticides world-wide. Although numerous studies have documented neonicotinoid toxicity in bees and other insects, the effects of exposure during early development in mammals remain largely unexplored. We assessed the effects of the neonicotinoid imidacloprid (IMI) in adult male and female mice after in utero and early postnatal exposure. Pregnant mice were infused with IMI (0.5 mg/kg/day) from gestational day 4 to the end of nursing at postnatal day 21. The young adult offspring were studied in a series of biochemical and behavioral tests. To assess reproducibility, the behavioral analyses were conducted in three separate studies using multiple exposed litters. Exposure to IMI reduced fecundity, and in adult offspring, decreased body weight in male but not female pups. Offspring from IMI-treated mothers displayed lower triglycerides, elevated motor activity, enhanced social dominance, reduced depressive-like behavior, and a diminution in social aggression compared to vehicle treated controls. Low levels of IMI were detected in the brains and livers of the treated mothers, while trace levels were detected in some offspring. Our results demonstrate that transient exposure to a neonicotinoid over the early developmental period induces long-lasting changes in behavior and brain function in mice.
Clumpiness of the interstellar medium in the central parsec of the Galaxy from H2 flux–extinction correlation
Authors: Ciurlo A. , Paumard T. , Rouan D. , Clénet Y. 
Published: November 2018

Context. The central parsec of the Galaxy contains a young star cluster embedded in a complex interstellar medium. The latter mainly consists of a torus of dense clumps and streams of molecular gas (the circumnuclear disk) enclosing streamers of ionized gas (the Minispiral).
Aims. In this complex environment, knowledge of the local extinction that locally affects each feature is crucial to properly study and disentangle them. We previously studied molecular gas in this region and inferred an extinction map from two H2 lines. Extinction appears to be correlated with the dereddened flux in several contiguous areas in the field of view. Here, we discuss the origin of this local correlation.
Methods. We model the observed effect with a simple radiative transfer model. H2 emission arises from the surfaces of clumps (i.e., shells) that are exposed to the ambient ultraviolet (UV) radiation field. We consider the shell at the surface of an emitting clump. The shell has a varying optical depth and a screen of dust in front of it. The optical depth varies from one line of sight to another, either because of varying extinction coefficient from the shell of one clump to that of another or because of a varying number of identical clumps on the line of sight.
Results. In both scenarios, the model accurately reproduces the dependence of molecular gas emission and extinction. The reason for this correlation is that, in the central parsec, the molecular gas is mixed everywhere with dust that locally affects the observed gas emission. In addition, there is extinction due to foreground (“screen”) dust.
Conclusions. This analysis favors a scenario where the central parsec is filled with clumps of dust and molecular gas. Separating foreground from local extinction allows for a probe for local conditions (H2 is mixed with dust) and can also constrain the three-dimensional (3D) position of objects under study.
Gaia-DR2 extended kinematical maps
Authors: López-Corredoira M. , Sylos Labini F. 
Published: November 2018

Context. The Gaia Collaboration has used Gaia-DR2 sources with six-dimensional (6D) phase space information to derive kinematical maps within 5 kpc of the Sun, which is a reachable range for stars with relative error in distance lower than 20%.
Aims. Here we aim to extend the range of distances by a factor of two to three, thus adding the range of Galactocentric distances between 13 kpc and 20 kpc to the previous maps, with their corresponding error and root mean square values.
Methods. We make use of the whole sample of stars of Gaia-DR2 including radial velocity measurements, which consists in more than seven million sources, and we apply a statistical deconvolution of the parallax errors based on the Lucy’s inversion method of the Fredholm integral equations of the first kind, without assuming any prior.
Results. The new extended maps provide lots of new and corroborated information about the disk kinematics: significant departures of circularity in the mean orbits with radial Galactocentric velocities between −20 and +20 km s−1 and vertical velocities between −10 and +10 km s−1; variations of the azimuthal velocity with position; asymmetries between the northern and the southern Galactic hemispheres, especially towards the anticenter that includes a larger azimuthal velocity in the south; and others.
Conclusions. These extended kinematical maps can be used to investigate the different dynamical models of our Galaxy, and we will present our own analyses in the forthcoming second part of this paper. At present, it is evident that the Milky Way is far from a simple stationary configuration in rotational equilibrium, but is characterized by streaming motions in all velocity components with conspicuous velocity gradients.
Neuer G-BA-Beschluss regelt Notfallstrukturen in
Krankenhäusern
Authors: Dormann Patrick , Wedler Katrin 
Published: November 2018

ZusammenfassungAm 19. April 2018 hat der Gemeinsame Bundesausschuss eine erste Fassung der
Regelung zu einem gestuften System von Notfallstrukturen in Krankenhäusern gemäß
§ 136c Absatz 4 SGB V beschlossen. Das Aktionsbündnis Notfallpflege hat sich den
Beschluss im Einzelnen angesehen und in einer Stellungnahme bewertet.
Giant Prolactinoma in Men: Clinical Features and Therapeutic Outcomes
Authors: Iglesias Pedro , Arcano Karina , Berrocal Víctor , Bernal Carmen , Villabona Carles , Díez Juan 
Published: November 2018

AbstractThe aim of the study was to evaluate the clinical features and long-term therapeutic outcome of giant prolactinoma (gPRLoma) in men and to compare them with those of a group of male patients with non-gPRL macroprolactinomas (non-gPRLomas). A retrospective and multicenter study of gPRLomas in men diagnosed in a 20-year period was performed. Clinical data and treatment outcome were registered. The diagnosis of gPRLoma was established when the maximal tumor diameter was ≥40 mm or the tumor had ≥20 mm of suprasellar extension associated to hyperprolactinemia (PRL>1000 ng/ml). Non-gPRLoma was considered when tumor diameter was  ≥ 10 mm and<40 mm associated to hyperprolactinemia (PRL≥200 ng/ml). Twenty-three patients with gPRLoma (age 38.3±13.5 years) followed for at least 3 months (follow-up 87.1±60.5 months, range 3–211 months) were evaluated. A group of 42 patients with non-gPRLoma (age 42±16.6 years; NS; follow-up 89±65.9 months, range 3–222 months; NS) served as a control group. More than half (56.5%) of the gPRLoma patients were younger than 40 years at diagnosis. Visual disturbances were significantly more common in gPRLoma than in non-gPRLoma patients (65.2 vs. 25.6%; p=0.004). Prevalence of hypopituitarism was similar in both groups of patients (73.9% vs. 80.9%; gPRLoma vs non-gPRLoma; NS). Serum PRL concentrations were significantly higher in gPRLoma than in non-gPRLoma patients [median (IR), 3978 ng/ml (1179–9012) vs. 907 ng/ml (428–3119); p<0.001]. Maximum tumor diameter in gPRLomas was 4.8±0.8 cm and 2.4±0.7 cm in non-gPRLoma (p<0.001). All patients were treated with dopamine agonists (DA). Twelve (52.2%) gPRLoma patients and 32 (73.8%) non-gPRLoma patients were treated with DA as monotherapy (p=0.045). Surgery was used in 12 (52.2%) gPRLoma patients and in 12 (28.6%) non-gPRLoma patients (p=0.054). Lastly, radiotherapy was used in 5 (21.7%) gPRLoma patients and in 6 (14.2%) non-gPRLoma patients (NS). At last visit, PRL was similar in both groups of patients [16 ng/ml (4–30) vs. 11 ng/ml (4–25); gPRLomas vs. non-gPRLomas; ns] and tumor size decreased significantly (p<0.001) in both groups of patients. Clinical cure (maintained normoprolactinemia without therapy for>1 year and no radiological evidence of pituitary tumor) was achieved in 2 (8.7%) gPRLoma patients and in 2 (4.8%) non-gPRLoma patients (NS). gPRLomas in men are usually diagnosed at a mean age of 40 years, an age similar to that of non-gPRLomas. The only clinical difference with non-gPRLomas is their greater prevalence of visual disturbances. The therapeutic approaches and tumor outcomes were similar to those obtained in patients with non-gPRLomas. Complete cure in gPRLoma is rare, but similar to that achieved in non-gPRLomas, reached in less than 10% of patients.
Image-Guided Bone Consolidation in Oncology
Authors: Catena Vittorio , Roubaud Guilhem , Crombe Amandine , Kind Michèle , Palussiere Jean , Buy Xavier 
Published: November 2018

AbstractOccurrence of bone metastases is a common event in oncology. Bone metastases are associated with pain, functional impairment, and fractures, particularly when weight-bearing bones are involved. Management of bone metastases has been improved by the development of various interventional radiology consolidation techniques. Cementoplasty is based on injection of acrylic cement into a weakened bone to reinforce it and to control pain. This minimally invasive technique has proven its efficacy for flat bone submitted to compression forces. However, resistance to torsion forces is limited and, thus, treatment of long bones should be considered with caution. In recent years, variant techniques of percutaneous bone consolidation have emerged, including expansion devices for vertebral augmentation and percutaneous screw fixation for pelvic bone and proximal femur tumors. Research projects are ongoing to develop drug-loaded cements to use them as therapeutic vectors. However, release of drugs is still poorly controlled and conventional polymethylmethacrylate cement remains the gold standard in oncology. Image-guided consolidation techniques enhance the array of treatments in bone oncology. Multidisciplinary approach is mandatory to select the best indications.
Percutaneous Fixation by Internal Cemented Screw for the Treatment of Unstable Osseous Disease in Cancer Patients
Authors: Yevich Steven , Gravel Guillaume , Roux Charles , Hakime Antoine , de Baère Thierry , Tselikas Lambros , Deschamps Frederic 
Published: November 2018

AbstractInterventional radiology expertise in image guidance has expanded the treatment options for cancer patients with unstable osseous disease. Percutaneous fixation by internal cemented screw (FICS) describes the technique by which the interventional radiologist stabilizes a fracture or impending fracture with the percutaneous placement of a cannulated screw that is locked in position by polymethyl methacrylate cement. The durable metallic screws provide added resistance to torque and tension stresses that complement the axial compression resistance of cement. Compared with cementoplasty alone, the procedure has been advanced as a more durable and precise technique for stabilization of osseous disease for certain disease presentations in cancer patients. The application of advanced image guidance techniques improves upon existing percutaneous surgical techniques to facilitate approaches that would otherwise prove quite challenging, particularly with stabilization of the pelvic flat bones. This article examines the applications of percutaneous FICS procedures for the treatment of unstable osseous disease in cancer patients. Indications, techniques, and follow-up care are reviewed. Case examples in which FICS can be performed in unstable pathology are detailed.
Musculoskeletal Metastases Management: The Interventional Radiologist's Toolbox
Authors: Gjorgjievska Ana , Thivolet Arnaud , Bouhamama Amine , Cuinet Marie , Pilleul Franck , Tselikas Lambros , de Baère Thierry , Deschamps Frederic , Mastier Charles 
Published: November 2018

AbstractThe prevalence of patients with painful bone metastases is constantly increasing. This is related to the rising incidence of cancer and increasing life expectancy of patients with metastatic stage. Advances in imaging and development of percutaneous techniques have gradually allowed offering minimally invasive acts on these metastases: cementing, vertebral augmentation, osteosynthesis, percutaneous thermal ablation, neurolysis, embolization. The purpose of this article is to present the main tools available to date for the interventional radiologist so that each participant can understand their functioning, indications, and limits.
Thermal Ablation of Bone Metastases
Authors: Kurup A. , Callstrom Matthew , Moynagh Michael 
Published: November 2018

AbstractImage-guided, minimally invasive, percutaneous thermal ablation of bone metastases has unique advantages compared with surgery or radiation therapy. Thermal ablation of osseous metastases may result in significant pain palliation, prevention of skeletal-related events, and durable local tumor control. This article will describe current thermal ablation techniques utilized to treat bone metastases, summarize contemporary evidence supporting such thermal ablation treatments, and outline an approach to percutaneous ablative treatment.