bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Hydrodilatation in Adhesive Capsulitis of Shoulder: A Systematic Review and Meta-Analysis
Authors: Saltychev M. , Laimi K. , Virolainen P. , Fredericson M. 
Published: May 2018

Background and Aims: Even though hydrodilatation has been used for 50 years, the evidence on its effectiveness is not clear. Only one earlier review has strictly focused on this treatment method. The aims of this study are to evaluate the evidence on the effectiveness of hydrodilatation in treatment of adhesive capsulitis and, if appropriate, to assess the correlation between the effects of this procedure and the amount of fluid injected. Materials and Methods: A literature search on MEDLINE, Embase, Scopus, Cochrane Central, Web of Science, and CINAHL databases was done; random-effects meta-analysis and meta-regression were employed; and cost-effectiveness and safeness analyses were left outside the scope of the review. Results: Of the 270 records identified through search, 12 studies were included in qualitative and quantitative analysis and seven were included in a meta-analysis. The lower 95% confidence interval for the effect of hydrodilatation on pain severity was 0.12 indicating small effect size and mean number needed to treat 12. The pooled effect of hydrodilatation on disability level was insignificant 0.2 (95% confidence interval: −0.04 to 0.44). The lower 95% confidence interval for the effect of hydrodilatation on the range of shoulder motion was close to zero (0.07) indicating small effect size with mean number needed to treat 12. The amount of injected solution did not have a substantial effect on pain severity or range of shoulder motion. The heterogeneity level I2 was acceptable from 0% to 60%. Conclusion: According to current evidence, hydrodilatation has only a small, clinically insignificant effect when treating adhesive capsulitis.
Long-Term Complications of Appendectomy: A Systematic Review
Authors: Rasmussen T. , Fonnes S. , Rosenberg J. 
Published: May 2018

Background and Aims: Appendectomy is a common surgical procedure, but no overview of the long-term consequences exists. Our aim was to systematically review the long-term complications of appendectomy for acute appendicitis. Materials and Methods: This systematic review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A protocol was registered on PROSPERO (CRD42017064662). The databases PubMed and EMBASE were searched for original reports on appendectomy with n ≥ 500 and follow-up >30 days. The surgical outcomes were ileus and incisional hernia; other outcomes were inflammatory bowel disease, cancer, fertility, and mortality. Results: We included 37 studies. The pooled estimate of the ileus prevalence was 1.0% over a follow-up period of 4.6 (range, 0.5–15) years. Regarding incisional hernia, we found a pooled estimate of 0.7% prevalence within a follow-up period of 6.5 (range, 1.9–10) years. Ulcerative colitis had a pooled estimate of 0.15% prevalence in the appendectomy group and 0.19% in controls. The opposite pattern was found regarding Crohn’s disease with a pooled estimate of 0.20% prevalence in the appendectomy group and 0.12% in controls. No clear pattern was found regarding most of the examined cancers in appendectomy groups compared with background populations. Pregnancy rates increased after appendicitis compared with controls in most studies. Mortality was low after appendectomy. Conclusion: Appendectomy had a low prevalence of long-term surgical complications. We did not find any significant other long-term complications, though the prevalence of Crohn’s disease was higher and the prevalence of ulcerative colitis was lower after appendectomy than in controls. Appendectomy did not impair fertility.
Platform development for primary blast injury studies
Authors: Nguyen Thuy-Tien N , Sory David R , Amin Harsh D , Rankin Sara M , Proud William G 
Published: May 2018

Explosion-related injuries are currently the most commonly occurring wounds in modern conflicts. They are observed in both military and civilian theatres, with complex injury pathophysiologies. Primary blast injuries are the most frequently encountered critical injuries experienced by victims close to the explosion. They are caused by large and rapid pressure changes of the blast waves which produce a wide range of loading patterns resulting in varied injuries. Well-characterised experimental loading devices which can reproduce the real mechanical characteristics of blast loadings on biological specimens in in vivo, ex vivo, and in vitro models are essential in determining the injury mechanisms. This paper discusses the performance and application of platforms, including shock tubes, mechanical testing machines, drop-weight rigs, and split-Hopkinson pressure bar, with regards to the replication of primary blast.
Excess stroke incidence in young Aboriginal people in South Australia: Pooled results from two population-based studies
Authors: Balabanski Anna H , Newbury Jonathan , Leyden James M , Arima Hisatomi , Anderson Craig S , Castle Sally , Cranefield Jennifer , Paterson Tracey , Thrift Amanda G , Katzenellenbogen Judith , Brown Alex , Kleinig Timothy J 
Published: May 2018

Background Retrospective data indicate increased stroke incidence in Aboriginal/Torres Strait Islander (Indigenous) Australians, possibly with poorer outcomes. We present the first prospective population-based stroke incidence study in Indigenous Australians. Methods We pooled data from ASCEND and SEARCH, two prospective “ideal” South Australian stroke incidence studies, ASCEND conducted in urban Northwestern Adelaide (2009–2010) and SEARCH in five South Australian rural centers (2009–2011). We calculated age-standardized incidence for Aboriginal and non-Aboriginal people. Results The study population comprised 261,403 inhabitants. Among 432 first-ever strokes, 13 were in Aboriginal people (median age 51 vs. 78 years for non-Aboriginal people, p < 0.001). Age-standardized stroke incidence per 100,000 in Aboriginal patients (116, 95% CI: 95–137) was nearly two-fold that of non-Aboriginal patients (67, 95% CI: 51–84). Age-stratified excess incidence in Aboriginal people was restricted to those aged < 55 years (incidence rate ratio (IRR) 3.5, 95% CI: 2–7), particularly for intracerebral hemorrhage (IRR: 16, 95% CI: 4–61). Conclusion The excess stroke incidence in Aboriginal South Australians appears substantial, especially in those aged <55 years. Further work is required to delineate and address disparities.
Dart to the target: an alternative bull’s eye parametric display for European Society of Cardiology / European Respiratory Society goal‐orientated risk reduction strategy in pulmonary arterial hypertension
Authors: Kaymaz Cihangir , Akbal Ozgur Yasar , Hakgor Aykun , Tokgoz Hacer Ceren , Tanyeri Seda 
Published: May 2018

Despite the significant mortality and mobidity benefits being obtained with the targeted therapies in patients with pulmonary arterial hypertension (PAH), mid‐ to long‐term survival of patients with this disease has remained unsatisfactory. For earlier and reliable risk stratification in PAH and tailoring the dynamic management strategies, various risk assessment models have been developed. Currently available risk reduction strategy recommended by the European Society of Cardiology (ESC)/European Respiratory Society (ERS) 2015 Pulmonary Hypertension Guidelines has been utilized in three recent registries. In this review, we evaluated the risk prediction models and management algorithms in this setting and propose an alternative parametric display, a bull’s eye, dart table scheme for ESC/ERS goal‐orientated risk reduction strategy in patients with PAH.
Responsiveness of the EQ-5D-3L in elective shoulder surgery: Does it adequately represent patient experience?
Authors: Evans J , Dattani Rupen , Ramasamy Vijayaraj , Patel Vipul 
Published: May 2018

Aim: Generic patient-reported outcome measures (PROMs) allow comparison of health-related quality of life across populations and pathologies. For these comparisons to be valid, the PROM must be responsive; the score must change when the patient’s quality of life changes. This study aims to assess the responsiveness of the EQ-5D-three level (3L) in elective shoulder surgery. Methods: Pre- and post-operative EQ-5D-3L and Oxford Shoulder Scores (OSS) were prospectively collected across a range of 204 elective shoulder surgeries. Internal responsiveness was assessed through significance testing of mean change scores and standardized response means (SRMs). External responsiveness of the EQ-5D-3L was assessed against the minimal clinically important difference in OSS, using receiver operating characteristic curve and change score correlation. Results: Both EQ-5D-3L and OSS scores improved significantly over time ( p < 0.05). The SRM for the EQ-5D was 1.27 (95% CI 1.14–1.41) and for OSS 2.36 (2.22–2.52). Area under the curve for EQ-5D was 0.49. Only a weak correlation was found between EQ-5D and OSS change scores ( r = 0.21). Discussion: The EQ-5D-3L is adequately internally responsive to change following elective shoulder surgery but is unable to differentiate patients demonstrating minimal clinically important change. The EQ-5D therefore only partially reflects patient experience.
RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice
Authors: Ng Samuel Y. , Brown Leon , Stevenson Kristen , deSouza Tiffany , Aster Jon C. , Louissaint Abner , Weinstock David M. 
Published: May 2018

Key PointsExpression of RhoA G17V in CD4+ cells results in cellular and humoral autoimmunity. RhoA G17V expression with Tet2 loss induces T-cell lymphomas with features of AITL.
Indoor mould exposure, asthma and rhinitis: findings from systematic reviews and recent longitudinal studies
Authors: Caillaud Denis , Leynaert Benedicte , Keirsbulck Marion , Nadif Rachel 
Published: May 2018

Starting from the Institute of Medicine (IOM) and World Health Organization (WHO) reports, this review provides an overview of the literature published from 2006 to 2017 on the associations between indoor mould exposure and asthma and rhinitis separately in children and adults with a focus on longitudinal epidemiological studies.A systematic search of peer-reviewed literature was performed, including systematic reviews and meta-analyses, longitudinal, incident case–control and panel studies. 61 publications were identified reporting visible mould or mould odour or quantitative assessment of culturable fungi or mould species.In children, visible mould and mould odour were associated with the development and exacerbations of asthma, providing sufficient evidence of a causal relationship. Results from population-based studies in adults were too few and divergent to conclude at more than a limited level of evidence. Exposure to mould in a work building was associated with the incidence and exacerbations of occupational asthma, and we concluded at a sufficient evidence for an association. Systematic reviews, meta-analyses and longitudinal studies on the relationships between mould exposure and allergic rhinitis provide sufficient evidence of an association.This review extended the conclusions of the IOM and WHO reports, and highlighted the need for further longitudinal studies on asthma in adults, and on rhinitis.
Treatment-Free Survival in Patients With Differentiated Thyroid Cancer
Authors: Banerjee Mousumi , Reyes-Gastelum David , Haymart Megan R 
Published: May 2018

Abstract

Objective
Cancer recurrence is a primary concern for patients with differentiated thyroid cancer; however, population-level data on recurrent or persistent disease do not currently exist. The objective of this study was to determine treated recurrent or persistent thyroid cancer by using a population-based registry, identify correlates of poor treatment-free survival, and define prognostic groups for treatment-free survival.

Methods
In this population-based study, we evaluated treatment-free survival in 9273 patients from the Surveillance, Epidemiology, and End Results Program–Medicare with a diagnosis of differentiated thyroid cancer between 1998 and 2012. Treated recurrence was defined by treatment of recurrent or persistent differentiated thyroid cancer with surgery, radioactive iodine, or radiation therapy at ≥1 year after diagnosis. Multivariable analysis was performed with Cox proportional hazards regression, survival trees, and random survival forests.

Results
In this cohort the median patient age at time of diagnosis was 69 years, and 75% of the patients were female. Using survival tree analyses, we identified five distinct prognostic groups (P < 0.001), with a prediction accuracy of 88.7%. The 5-year treatment-free survival rates of these prognostic groups were 96%, 91%, 85%, 72%, and 52%, respectively, and the 10-year treatment-free survival rates were 94%, 87%, 80%, 64%, and 39%. Based on survival forest analysis, the most important factors for predicting treatment-free survival were stage, tumor size, and receipt of radioactive iodine.

Conclusion
In this population-based cohort, five prognostic groups for treatment-free survival were identified. Understanding treatment-free survival has implications for the care and long-term surveillance of patients with differentiated thyroid cancer.
Drama as a community engagement strategy for malaria in rural Cambodia
Authors: Lim Renly , Tripura Rupam , J Peto Thomas , Sareth Ma , Sanann Nou , Davoeung Chan , Nguon Chea , Cheah Phaik Yeong 
Published: May 2018

Background: Countries in Southeast Asia are working to eliminate multidrug-resistant falciparum malaria, a major cause of mortality in tropical regions. Malaria is declining but transmission persists in many rural areas and among forest workers and isolated populations. In these remote communities, conventional health services and education are limited. Mobilising and educating these populations require new approaches as many people are illiterate and do not attend village meetings. This article describes a qualitative study to assess the feasibility of a drama project as a community engagement strategy. Methods: A drama project was conducted in twenty villages in Cambodia with three key messages: to use insecticide-treated bednets and repellents, to get early diagnosis and treatment, and to learn about risks of forest-acquired malaria. Qualitative interviews were conducted with the drama team members, village malaria workers, local health staffs and villagers, to explore the feasibility of using drama to engage the community and the associated challenges. Results: 29 people were interviewed, which included 18 semi-structured interviews and one focus group discussion. Analysis of the interviews resulted in development of the following seven themes: i) exposure to malaria and engagement activities, ii) readiness and barriers to participation, iii) understanding and learning about malaria using drama, iv) entertainment value and engagement method preferences, v) challenges to community engagement, vi) future participation and vii) sustainability. The event saw a very positive response, with an encouraging average participation rate of 66%. The project faced several challenges including logistic problems, rescheduling due to raining season, and time- and budget-constraints. Conclusions: Our evaluation demonstrated that the drama project was feasible in promoting awareness and understanding of malaria prevention and control. Audience members perceived drama as entertaining and as the preferred choice of engagement activity. Participatory drama could be considered as part of the community engagement for malaria elimination.
Evaluation Of Zinc-Bearing Palygorskite Effects on Growth Performance, Nutrient Retention, Meat Quality, and Zinc Accumulation in Blunt Snout Bream Megalobrama Amblycephala
Authors: Zhang Ruiqiang , Zhou Yanmin , Jiang Xueying , Chen Yueping , Wen Chao , Liu Wenbin , Jiang Ying 
Published: May 2018

AbstractZinc (Zn) is widely known as an essential trace element for fish and new ways to supply it to them are needed. Palygorskite (Pal) is a natural silicate clay mineral and the palygorskite structure contains nano-channels, which are filled with water and exchangeable ions. Zn-bearing palygorskites (Zn-Pal) prepared using ion exchange have attracted attention due to the durable antibacterial properties that limit pathogens and as a potential new Zn source for livestock. The present study was conducted to evaluate the effects of Zn-Pal supplementation on the growth performance, nutrient retention, meat quality, Zn accumulation, and intestinal Zn transporter protein gene expression in blunt snout bream Megalobrama amblycephala. The fish were fed a basal diet without an exogenous Zn source and the basal diet was supplemented with 125 mg/kg Zn as Zn sulfate (ZnSO4) or 35, 80, or 125 mg/kg Zn as Zn-Pal. Each diet was tested using three replicates for 7 weeks. The results showed that dietary Zn-Pal supplementation quadratically (P<0.05) increased growth performance, nutrient retention, total and Cu/Zn superoxide dismutase activity, Zn content in scales, and intestinal Zn transporter protein gene expression. The muscular cooking loss in blunt snout bream decreased with the optimum Zn-Pal Zn level of 35 mg/kg. Compared to the fish treated with ZnSO4, the fish supplemented with 35 mg/kg as Zn-Pal exhibited similar growth performance and nutrient retention (P>0.05), increased mRNA expression of the metal-response element-binding transcription factor-1 in the intestine (P<0.05), and decreased cooking loss of muscle (P<0.05).The results suggested that 35 mg/kg Zn supplementation as Zn-Pal could improve the growth performance and body composition, increase nutrient retention and tissue Zn concentrations, enhance the muscle water-holding capacity, and enhance antioxidant status in blunt snout bream. The Zn-Pal was more efficient and could be used as an alternative Zn source to ZnSO4 in the diet of blunt snout bream.
Ultrasound-Assisted Ultra-Mild-Acid Hydrolisis of -Carrageenan
Authors: Ratnawati Ratnawati , Indriyani Nita 
Published: May 2018

The low molecular weight fraction of κ-carrageenan is useful in biomedical applications. An ultrasound-assisted acid hydrolysis of κ-carrageenan has been studied. κ-carrageenan with an initial number-average molecular weight of 629 kDa was dispersed in distilled water to form a 5 g/l solution. The pH (3 and 6) of the solution was adjusted by adding HCl solution. The depolymerization reaction was carried out in an ultrasonic device at various temperatures (30, 40, 50, and 60°C) and times (8, 16, 24, and 32 min). The experimental results showed that ultrasound positively contributed to acid hydrolysis process. The number-average molecular weight of the treated k-carrageenan was lower or the percentage of reduction was higher at lower pH, longer reaction time, and higher temperature. The lowest number-average molecular weight (14 kDa) or the highest percent of molecular weight reduction reduction (97.7%) was achieved after ultrasonic irradiation at 60°C and pH 3 for 32 min. Keywords: depolymerization; midpoint scission; ultrasonication
A new proof of Kirchberg's 𝒪2-stable classification
Authors: Gabe James 
Published: May 2018

Abstract
I present a new proof of Kirchberg’s

𝒪
2

\mathcal{O}_{2}

-stable classification theorem: two separable, nuclear, stable/unital,

𝒪
2

\mathcal{O}_{2}

-stable

C
∗

C^{\ast}

-algebras are isomorphic if and only if their ideal lattices are order isomorphic, or equivalently, their primitive ideal spaces are homeomorphic.
Many intermediate results do not depend on pure infiniteness of any sort.
Die bewegte Bellona
Authors: Schröder Martin 
Published: May 2018

Zusammenfassung
Im Vergleich zu vorigen Epochen galt es nach 1648 die Grundbedürfnisse von Soldaten und Zivilbevölkerung auf Dauer auszugleichen. Eine Verstetigung der Heere zog dabei nicht nur eine dauerhafte Militärverwaltung innerhalb der Territorien nach sich, sondern eben auch eine beständige Notwendigkeit zur Organisation von Truppendurchzügen. Dem wird in der vorliegenden Untersuchung mit einem Durchzug welfischer Kontingente durch Kursachsen im Jahr 1685 nachgegangen. Im Verhalten der kursächsischen Regierung und der restlichen Beteiligten wird die Organisation von Durchzügen am Ende des 17. Jahrhunderts beispielhaft erkennbar. Mithilfe von administrativen, diplomatischen und militärischen Maßnahmen versuchten die kursächsischen Räte, die Einhaltung von vereinbarten Marschkonditionen, Routenverläufen und der Reichsgesetze durchzusetzen. Dies diente nicht allein der Schonung der Untertanen, sondern gleichsam den dynastischen Interessen Dresdens. Die Lenkung der welfischen Soldaten auf Gebiete der albertinischen Nebenlinien oder auf auswärtige Territorien schonte die eigenen Ressourcen und schmälerte zugleich diejenigen benachbarter Fürsten. Mit der Organisation des Durchzugs griff die Dresdner Verwaltung auf periphere Landesteile zu, was als Herrschaftsverdichtung bewertet werden kann.
»Wüstenfuchs« und »Bluthund« in den Alpen. Erwin Rommel und Ferdinand Schörner in der Schlacht von Karfreit 1917
Authors: Lieb Peter 
Published: May 2018

Zusammenfassung
Erwin Rommel und Ferdinand Schörner, zwei der bekanntesten Generalfeldmarschälle der Wehrmacht, kämpften im Herbst 1917 als junge Leutnants gemeinsam in der Durchbruchsschlacht von Karfreit. Für ihre Taten erhielten beide die höchste preußische Tapferkeitsauszeichnung verliehen: den Pour le Mérite. Der Aufsatz analysiert anhand der überlieferten Kriegstagebücher die genaue Rolle von Rommel und Schörner in der Schlacht. In der Tat leisteten die zwei jungen Offiziere mit ihren Kompanien einen entscheidenden Beitrag zur Einnahme des wichtigen Gebirgszugs über dem Isonzo-Tal und damit zum Gelingen der Gesamtoperation. Einerseits zeigt ihr Verhalten in der Schlacht recht deutlich ihre Charakterzüge und andererseits bietet ihr taktischer Ansatz auch einen möglichen Aufschluss für ihr späteres Agieren im Zweiten Weltkrieg auf operativer Ebene. Es spricht vieles dafür, dass Karfreit für Rommel und Schörner ein Schlüsselerlebnis in ihren Karrieren war.
Crystal structure of 6-amino-8-(2-methoxy-phenyl)-2-methyl-2,3,8,8a-tetrahydro-1H-iso-quinoline-5,7,7-tricarbonitrile monohydrate, C20H21N5O2
Authors: Quan Yan 
Published: May 2018

Abstract
C20H21N5O2, monoclinic, P21/c (no. 14), a = 14.594(4) Å, b = 9.366(5) Å, c = 14.147(4) Å, β = 93.749(18)°, V = 1929.6(12) Å3, Z = 4, R
gt(F) = 0.061, wR
ref(F
2) = 0.213, T = 296(2) K.
Crystal structure of 2-isopropyl-8-methyl-phenanthrene-3,4-dione, C18H16O2
Authors: Wu Jichun , Luo Guoyong , Liu Yuchen , Yang Wude 
Published: May 2018

Abstract
C18H16O2, orthorhombic, Pnma (no. 62), a = 14.474(6) Å, b = 6.815(3) Å, c = 13.738(6) Å, V = 1355.1(10) Å3, Z = 4, R
gt(F) = 0.0583, wR
ref(F
2) = 0.1759, T = 173 K.