bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of C-Arm Position on Femoral Tunnel Placement in Medial Patellofemoral Ligament Reconstruction
Authors: Thürig Grégoire , Herbst Elmar , Deichsel Adrian , Peez Christian , Briese Thorben , Glasbrenner Johannes , Raschke Michael J. , Kittl Christoph 
Published: November 2024

Background: Medial patellofemoral ligament (MPFL) reconstruction is a common treatment for patellar instability. Yet nearly 40% of revisions result from femoral tunnel misplacement. One reason may be the positioning of the C-arm relative to the knee. Purpose: To assess how the C-arm’s position affects femoral MPFL placement when the image receptor is positioned either contralateral or ipsilateral to the operated knee. Study Design: Controlled laboratory study. Methods: Ten human cadaveric knee specimens were dissected, and the femoral MPFL insertion site was identified and marked using a 10-mm eyelet. According to the possible clinical scenarios, true lateral radiographs in 2 different C-arm positions were taken. In the first scenario, the image receptor was on the ipsilateral side, being 5 cm away from the knee with the x-ray beam directed from medial to lateral (ML5). In the second scenario, the image receptor was on the contralateral side, being 25 cm away from the knee with the x-ray beam directed from lateral to medial (LM25). In each radiograph, the eyelet position was recorded and the distance (proximal-distal and anterior-posterior) from the optimal radiographic insertion point according to the literature was determined. Differences between the groups were calculated using the Wilcoxon signed-rank test, and a P value of <.05 was considered significant. Results: The anatomic femoral MPFL insertion in the ML5-position was located a mean of 2.7 ± 2.4 mm proximal and 4.5 ± 5.5 mm anterior to the Schöttle point. This resulted in an absolute distance of 7.2 ± 3.0 mm. In the LM25-position, it was located a mean of –0.7 ± 1.8 mm distal and 3.0 ± 5.3 mm anterior, which resulted in an absolute distance of 5.4 ± 3.2 mm. The ML5 was located more anterior (1.5 ± 2.1 mm) and proximal (3.4 ± 2.4 mm) compared with the LM25 position. Measurements following methods described in the literature significantly differed in both axes in the LM25 view when compared with the ML5 view measurements ( P = .005). Conclusion: Compared with the ipsilateral C-arm position (ML5), the contralateral C-arm position (LM25) showed a smaller range with a lower standard deviation in identifying the femoral MPFL approach across all measurement methods. Clinical Relevance: When applying the method according to Schöttle et al to locate the femoral MPFL insertion point, it should be noted that in the proximal-distal orientation, the femoral MPFL insertion point is situated proximal to the Blumensaat line in the contralateral view (LM25). In contrast, when using the ipsilateral view (ML5), the femoral MPFL footprint is positioned just distal to the proximal edge of the medial condyle.
Unicompartmental Knee Arthroplasty Versus Opening-Wedge High Tibial Osteotomy for Spontaneous Osteonecrosis of the Knee: A Retrospective Cohort Study
Authors: Chiu Si-Qi , Wong Chin-Chean , Chuang Andrew E.-Y. , Chen Chih-Hwa , Tan Cheng-Aun , Weng Pei-Wei 
Published: November 2024

Background: Unicompartmental knee arthroplasty (UKA) and high tibial osteotomy (HTO) are treatment options for patients with medial spontaneous osteonecrosis of the knee (SONK). Purpose: To compare the clinical outcomes after UKA and HTO in patients with SONK. Study Design: Cohort study; Level of evidence, 3. Methods: This retrospective study included 42 patients who had undergone Oxford UKA and 40 patients who had undergone opening-wedge HTO between 2014 and 2020. All patients were diagnosed with isolated medial SONK without subchondral collapse of the femoral condyle and tibial plateau. The patients were preoperatively and postoperatively evaluated using the Lysholm knee scoring system, the Western Ontario and McMaster Universities Osteoarthritis Index, and a numeric rating scale assessing patient satisfaction. Results: Patients in the UKA group were significantly older than those in the HTO group (median age, 71.5 years [IQR, 68.0-76.5 years] vs 65.0 years [IQR, 60.0-70.0 years], respectively; P < .001). The median follow-up time was 3.78 years (IQR, 2.45-4.53 years) for the UKA group and 3.87 years (IQR, 2.90-5.60 years) for the HTO group. Significant improvements in functional scores were observed in both the UKA and HTO groups ( P < .001 for all), with no significant between-group differences in scores at the final follow-up (≥2 years after surgery). The satisfaction rate was similar (80.95% for UKA and 75.0% for HTO). Conclusion: According to the study results, significant improvements in clinical outcomes were seen after opening-wedge HTO with microfracture for a younger group of patients with SONK without subchondral collapse, while Oxford UKA had a comparable effect on an older group of patients. Both UKA and HTO were found to be viable surgical approaches for SONK at short- to midterm follow-up.
What are Juvenile-onset systemic sclerosis providers thoughts, experiences, and reasons for autologous stem cell transplant? Result of a multinational survey
Authors: Foeldvari Ivan , Branton Samantha , Li Suzanne C , Rosser Franziska J , Torok Kathryn S 
Published: November 2024

Objective: Juvenile-onset systemic sclerosis (jSSc) is a rare and life-threatening disease with no formal studies evaluating the indications for, access to, or benefits of autologous stem cell transplantation (ASCT). As a first step toward understanding pediatric jSSc specialist thoughts and experiences with ASCT, we conducted a multinational survey. Methods: An electronic survey was developed and distributed in November 2023 to members of the Pediatric Rheumatology European Society (PRES) and/or Childhood Arthritis and Rheumatology Research Alliance (CARRA) pediatric scleroderma workgroups. Results: Twenty-nine (69%) jSSc specialists completed the survey. All participants have considered or would consider ASCT referral for a jSSc patient. Nearly all respondents indicated disease-modifying anti-rheumatic drugs (DMARDs) should be trialed prior to ASCT referral, with most indicating two to four DMARDs. The most common reasons selected for referral were rapidly progressive disease (despite DMARD) (90%), followed by severe disease status (83%), and significant impact on quality of life (83%). All respondents selected pulmonary disease as an indication for referral, followed by cardiac (93%), gastrointestinal (72%), and skin disease (66%). While pulmonary and cardiac involvement were considered individually sufficient for referral for ASCT, only a minority considered musculoskeletal involvement (28%) sufficient on its own. Conclusion: This survey is the first explore thoughts and experience with ASCT for jSSc. Results indicate pediatric rheumatologists were aware of and would consider ASCT for their patients. Our results indicate there is likely some variability in clinical practice regarding who is referred for ASCT, and further research is needed to guide development of evidence-based clinical care guidelines.
Microbial biopesticides are inhibited by honey bee royal jelly and in vitro larval diet
Authors: Schmehl Daniel R. , Larsen David , Gomez Camille , Ortego Lisa 
Published: November 2024

AbstractThe interest in and use of biological materials in crop production is increasing globally at a rapid pace. In many cases, testing methods for conventional chemicals are applied to microbial-based biopesticides because specific microbial test methods are lacking. However, not all methods are easily transferred to microbial-based products. An evaluation was conducted to determine if OECD (Organization for Economic Co-operation and Development) Guidance Document No. 239 on honey bee larval toxicity could be adapted to microbial pesticides. In our study, five microbes, including B. pumilus, B. thuringiensis, B. velezensis, Paenibacillus larvae, and Ascophaera apis were grown on agar media and spotted with either honey bee in vitro larval diet or royal jelly. We observed that the honey bee larval bee diet and royal jelly did not inhibit the fungal honey bee pathogen Ascophaera apis, yet inhibited the growth of bacteria, including a known honey bee larval pathogen. This finding may make the test unreliable for certain biopesticides. The OECD is considering biopesticide-specific testing guidelines, and the EPA has indicated it to update itsbiopesticide bee test guidelines. However, additional research is needed to determine which options may be feasible and provide the best improvements.
Chromosome-scale assembly of apple mint (Mentha suaveolens)
Authors: Firl Alana , Lieberman Meric C. , Kippes Nestor , Tsai Helen , Dowd Eric , Comai Luca , Henry Isabelle M. 
Published: November 2024

Abstract
Objectives
Mint oil is used in various commercial applications world-wide. Mint oil is typically harvested from commercial clones of peppermint or spearmints. Spearmints are the product of a cross between two diploid species: Mentha longifolia (horse mint) and Mentha suaveolens (apple mint). Peppermints are the product of an additional hybridization step between spearmint and an octoploid Mentha aquatica (water mint). Here, we present a chromosome-scale assembly of the genome of a clone of M. suaveolens. Together with the previously assembled genome of M. longifolia, these assemblies are instrumental in addressing questions regarding the origins of spearmint and peppermint oil and the genomic composition of commercial spearmints, and to start elaborating strategies for mint cultivar improvement.

Data description
A Falcon assembly of the genome of M. suaveolens was generated from 103X coverage of PacBio long reads. Additional scaffolding was conducted by Dovetail Genomics, using a Chicago library, and a HiC library. The resulting assembly had an N50 of 44.7 Mb, and 98.45% of the 536 Mb of the assembly were contained within 12 large superscaffolds. Finally, a genetic map was applied to correct persistent misjoins. Illumina RNA-Seq libraries from a variety of tissues were used to annotate the genome.
Assessing the impact of ecological, climatic, and socioeconomic factors on age-specific malaria incidence in India: a mixed-model approach using the Global Burden of Disease Study (2010–2019)
Authors: Padhi Bijaya K. , Gaidhane Abhay M. , Satapathy Prakasini , Bushi Ganesh , Ballal Suhas , Bansal Pooja , Tomar Balvir S. , Ashraf Ayash , Kumar M. Ravi , Rawat Pramod , Garout Mohammed , Aljebaly Fatimah S. , Sabour Amal A. , Alshiekheid Maha A. , Al Kaabi Nawal A. , Alrasheed Hayam A. , Al-Subaie Maha F. , Rabaan Ali A. , Saif Ahmed , Rustagi Sarvesh , Zahiruddin Quazi Syed , Shabil Muhammed 
Published: November 2024

Abstract
Background
Malaria continues to be a critical public health concern in India, predominantly driven by complex interplays of ecological, climatic, and socioeconomic factors.

Methods
This study aimed to assess the association between climatic variables (temperature and precipitation) and malaria incidence across India from 2010 to 2019, utilizing data from the Global Historical Weather and Climate Data for climate metrics and the Global Burden of Disease Study for malaria incidence rates. Generalized Linear Mixed Models (GLMMs) with a Poisson distribution were employed to analyze the data, adjusting for socio-economic status, as indexed by the Human Development Index (HDI).

Results
The results indicated a declining trend in both the number of malaria cases and age-specific incidence rates (ASIR) over the study period. In 2010, India reported approximately 20.7 million cases with an ASIR of 1688.86 per 100,000 population, which significantly reduced to 9.8 million cases and an ASIR of 700.80 by 2019. High malaria incidence was consistently observed in the states of Jharkhand and Odisha, whereas Sikkim reported the lowest numbers. Statistical analysis identified significant associations between malaria incidence and both temperature deviations and precipitation levels, with variations also linked to HDI, suggesting better detection and reporting capabilities in more developed areas.

Conclusion
The study underscores the critical interactions between climatic variables and socio-economic factors in shaping the trends of malaria incidence across India. These findings highlight the necessity for adaptive, localized public health strategies that integrate environmental monitoring with socio-economic data to efficiently predict and manage malaria outbreaks.
Mapping normal faults on the outer slope of the western Kuril Trench based on recent seismic reflection and bathymetric data
Authors: No Tetsuo , Kodaira Shuichi , Imai Kentaro , Obana Koichiro , Fujie Gou , Nakamura Yasuyuki , Shiraishi Kazuya , Miura Ryo , Nakanishi Masao 
Published: November 2024

AbstractTo obtain novel information regarding normal faults that could cause tsunamis and large earthquakes on the outer slopes of the Kuril Trench, recently acquired multichannel seismic reflection (MCS) and bathymetric data are processed in this study to interpret the normal faults on the outer slope of the western Kuril Trench from near the Erimo Seamount to near the Nosappu Fracture Zone. This work also assesses the distribution and characteristics of the faults through comparisons with previous studies on the outer slope faults of the Japan Trench. The results of this study show that faulting starts approximately 100 km seaward of the trench axis, and a comparison with the normal fault distributions on the outer slope of the Japan Trench presented in previous studies reveals that the outer slope region of the Kuril Trench is narrower and more densely faulted than that of the Japan Trench. Additionally, the seismic and bathymetric data show that the Erimo and Takuyo-Daiichi Seamounts are deformed by normal faults. However, the number of faults in the seamount areas is lower than that in areas without them, which also affects the scale of the fault throws. The results of the MCS survey reveal that the thickness of the oceanic crust varies between 6 and 10 km due to the presence of these seamounts. Considering the positions of the outer swells presented in previous studies, the results suggest that the crustal and plate structures in the study area influence the distribution and formation of faults on the outer slope of the Kuril Trench.
Graphical Abstract
Organ-preserving embolization of a giant splenic hemangioma in an adult
Authors: Siderakis Manos , Dodoura Stamatia , Gkeneralis George , Kartsouni Viktoria , Gkeli Myrsini 
Published: November 2024

AbstractSplenic hemangioma is a rare benign tumor, often found incidentally. Large hemangiomas bear a high risk of spontaneous rupture, an acute condition often life-threatening that requires immediate intervention. The spleen’s vital role in immunity and blood filtration mandates organ-preserving management of conditions such as hypersplenism or large lesions such as hemangiomas. A 51-year-old patient was referred to our department for abdominal pain due to a giant spleen hemangioma (6,6 × 6,3 × 5,6) cm in size. The patient was treated with hemangioma embolization through the splenic artery branches that fed the lesion, without any complications. Two years post-embolization the patient mentioned no symptoms and the hemangioma was measured (3 × 2) cm.Background The patient was referred to our department due to the large size of the lesion and the patient’s preference to avoid surgery and maintain the spleen. Our case report aims to underline (a) the safety and feasibility of the protocol among interventional radiologists, surgeons, and patients, (b) the benefit of relieving symptoms without losing a vital organ, and (c) the lower complication rate and hospital days compared with surgery. There are few reported cases of embolization of large spleen hemangioma. While Choi et al. (BMC Pediatr. 2018 12;18(1):354) report a similar case in a child. This case report describes the procedure in a stable adult and provides a 2-year follow-up.
Graphical Abstract
Cervicovaginal lavages uncover growth factors as key biomarkers for early diagnosis and prognosis of endometrial cancer
Authors: Harris Hannah J. , Łaniewski Paweł , Cui Haiyan , Roe Denise J. , Chase Dana M. , Herbst-Kralovetz Melissa M. 
Published: November 2024

AbstractEndometrial cancer (EC) rates are continuing to rise and it remains the most common gynecologic cancer in the US. Existing diagnostic methods are invasive and can cause pain and anxiety. Hence, there is a need for less invasive diagnostics for early EC detection. The study objective was to evaluate the utility of growth factors collected through minimally invasive cervicovaginal lavage (CVL) sampling as diagnostic and prognostic biomarkers for EC. CVL samples from 192 individuals undergoing hysterectomy for benign or malignant conditions were collected and used to quantify the concentrations of 19 growth and angiogenic factors using multiplex immunoassays. Patients were categorized based on disease groups: benign conditions (n = 108), endometrial hyperplasia (n = 18), and EC (n = 66). EC group was stratified into grade 1/2 endometrial endometrioid cancer (n = 53) and other EC subtypes (n = 13). Statistical associations were assessed using receiver operating characteristics, Spearman correlations and hierarchical clustering. Growth and angiogenic factors: angiopoietin-2, endoglin, fibroblast activation protein (FAP), melanoma inhibitory activity, and vascular endothelial growth factor-A (VEGF-A) were significantly (p < 0.0001) elevated in EC patients. A multivariate model combining 11 proteins with patient age and body mass index exhibited excellent discriminatory potential (area under curve = 0.918) for EC, with a specificity of 90.7% and a sensitivity of 87.8%. Moreover, angiopoietin-2, FAP and VEGF-A significantly (p < 0.05–0.001) associated with tumor grade, size, myometrial invasion, and mismatch repair status. Our results highlight the innovative use of growth and angiogenic factors collected through CVL sampling for the detecting endometrial cancer, showcasing not only their diagnostic potential but also their prognostic value.
Floating ascending aortic thrombus with antiphospholipid syndrome: a case report
Authors: Tajima Shinya , Kudo Tomoaki , Mori Daisuke , Kitabayashi Katsukiyo 
Published: November 2024

Abstract
Background
Ascending aortic thrombus is a rare disease that can cause fatal thromboembolism. The treatment for the disease is not well defined and depends on the clinical experience of surgeons. Most reports of thrombosis in antiphospholipid syndrome (APS) are associated with venous or peripheral arterial thrombosis, and there are almost no reports of thrombosis of the aorta.

Case presentation
A 74-year-old male was referred to our department with claudication of the left leg lasting 3 months. A computed tomography angiography (CTA) and a transthoracic echocardiography demonstrated that a floating and pedunculated mass associated with APS was located at ascending aortic lumen and an embolism in the left superficial femoral artery. Under deep hypothermic circulatory arrest, we resected a floating mass without the graft replacement. CTA 1 year after surgery showed no recurrence of thrombus.

Conclusion
We experienced a rare case of floating ascending aortic thrombi. As in this case, we consider that a floating ascending aortic thrombus with embolic events should be performed by surgical intervention.
Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA
Authors: Burnett Samuel B. , Culver Allison M. , Simon Tricia A. , Rowson Taylor , Frederick Kenneth , Palmer Kristina , Murray Stephen A. , Davis Shannon W. , Patel Rekha C. 
Published: November 2024

ABSTRACT
Variants in the PRKRA gene, which encodes PACT, cause the early-onset primary dystonia DYT-PRKRA, a movement disorder associated with disruption of coordinated muscle movements. PACT and its murine homolog RAX activate protein kinase R (PKR; also known as EIF2AK2) by a direct interaction in response to cellular stressors to mediate phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α). Mice homozygous for a naturally arisen, recessively inherited frameshift mutation, Prkralear-5J, exhibit progressive dystonia. In the present study, we investigated the biochemical and developmental consequences of the Prkralear-5J mutation. Our results indicated that the truncated PACT/RAX protein retains its ability to interact with PKR but inhibits PKR activation. Mice homozygous for the mutation showed abnormalities in cerebellar development as well as a severe lack of dendritic arborization of Purkinje neurons. Additionally, reduced eIF2α phosphorylation was noted in the cerebellum and Purkinje neurons of the homozygous Prkralear-5J mice. These findings indicate that PACT/RAX-mediated regulation of PKR activity and eIF2α phosphorylation plays a role in cerebellar development and contributes to the dystonia phenotype resulting from the Prkralear-5J mutation.
An Intertemporal Risk Factor Model
Authors: Chabi-Yo Fousseni , Gonçalves Andrei S. , Loudis Johnathan A. 
Published: November 2024

Prominent factor models are based on tradable factors that do not represent theoretically relevant risks. To address this issue, we develop a factor model that captures the risks to long-term investors present in the intertemporal capital asset pricing model (ICAPM). Empirically, we construct intertemporal risk factors as long-short portfolios based on stock exposures to dividend yield and realized variance. These tradable factors mimic news to long-term expected returns and volatility, and they offset part of the marginal utility increase in recessions induced by wealth declines. Our intertemporal factor model estimation implies significant risk prices that are consistent with the ICAPM restrictions under moderate risk aversion. Moreover, our model performs well relative to previous factor models in terms of its tangency Sharpe ratio and its pricing of key test assets, including single stocks, industry portfolios, and portfolios sorted on risk exposures and lagged anomalies. This paper was accepted by Will Cong, finance. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00261 .
Instructions and Incentives in Organizations
Authors: Meagher Kieron J. , Prasad Suraj , Wait Andrew 
Published: November 2024

We propose a different perspective on organizations, emphasizing the role of instructions in providing incentives. In our framework, there is a conflict of interest between a principal and an agent over the course of action. When preferences are aligned over executing a course, the principal can selectively instruct the agent on a preferred course to steer the agent toward it. Because less able (less confident) agents are more responsive to instructions, hiring these types of agents can be beneficial. This steering role of instructions toward a course of action helps us understand why and when firms are reluctant to hire overqualified (high-ability) workers, how worker risk aversion can be valuable to an organization, why instructions, although more likely to be used, are less intense, in more uncertain environments, and why instruction-giving and incentive pay go hand-in-hand. This paper was accepted by Joshua Gans, business strategy.