bluuebunny/crossref_metadata_2025_split huggingface dataset:
Влияние распространения цифровых технологий на результаты учащихся по странам мира и регионам России
Authors: М.Г. Дубинина 
Published: November 2024

В статье рассмотрено влияние распространения цифровых технологий в образовании на баллы, полученные учащимися разных стран по математической и естественно-научной грамотности в рамках международного мониторингового исследования качества школьного математического и естественно-научного образования (Trends in International Mathematics and Science Study, TIMSS 2019 г.). Кроме того, анализировалась зависимость среднего балла ЕГЭ по математике, русскому языку и информатике от оснащенности школ регионов России компьютерами за 2019 и 2020 гг.
The article considers the impact of the digital technologies diffusion in education on the scores obtained by students from different countries in mathematics and science literacy as part of the international monitoring study of the quality of school mathematics and science education (Trends in International Mathematics and Science Study, TIMSS 2019). In addition, the dependence of the average USE score in mathematics, Russian language and computer science on the equipment of schools in Russian regions with computers for 2019 and 2020 was analyzed.
Результативность модернизации российского школьного образования
Authors: И.А. Бобкова 
Published: November 2024

В работе рассматриваются проблемы, связанные с модернизацией российской образовательной системы, начатой в 2000-х годах, анализируются результаты реформирования на примере изменения математической подготовки выпускников девятых классов.
The paper examines the problems associated with the modernization of the Russian educational system, which began in the 2000s, analyzes the results of the reform by the example of changes in the mathematical training of ninth grade students.
Динамика количества убыточных предприятий и инновационная активность в отраслях химической промышленности
Authors: А.М. Хахладжиян 
Published: November 2024

В работе представлен анализ динамики количества убыточных предприятий в обрабатывающих производствах и в отраслях химической промышленности. Отмечается положительная динамика сокращения количества убыточных предприятий в химической промышленности, наибольшая их доля наблюдается в производстве прочей неметаллической минеральной продукции. С 2018 г. по сравнению с предыдущим периодом этот вид деятельности отличает существенно меньшее число убыточных предприятий, а уровень инновационной активности предприятий увеличился.
The paper presents an analysis of the dynamics of the number of unprofitable enterprises in manufacturing and chemical industries. There is a positive trend in reducing the number of unprofitable enterprises in the chemical industry, their largest share is observed in the production of other non-metallic mineral products. Since 2018, compared to the previous period, this type of activity has significantly fewer unprofitable enterprises, and the level of innovative activity of enterprises has increased.
Необходимость учета предложений ученых для ускорения технологического развития страны
Authors: А.Е. Варшавский 
Published: November 2024

В статье на основе анализа ряда научных работ, опубликованных в течение большого периода времени, рассмотрены предложения ведущих российских ученых - представителей академической, отраслевой и вузовской науки, нацеленные на ускорение научно-технологического развития России. Показывается, что эти предложения в большинстве своем длительное время не учитывались, однако многие из них, даже сделанные два-три десятилетия тому назад, остаются актуальными и в настоящее время. Также рассмотрены некоторые тенденции и показатели экономического, технологического и социального развития, требующие особого внимания при реализации программы ускорения технологического развития страны.Based on the analysis of a number of scientific works published over a long period of time, the article considers the proposals of leading Russian scientists - representatives of academic, industrial and university science, aimed at accelerating the scientific and technological development of Russia. It is shown that these proposals for the most part were not taken into account for a long time, however, many of them, even those made two or three decades ago, remain relevant at the present time. Some trends and indicators of economic, technological and social development, requiring special attention in the implementation of the program for accelerating the technological development of the country are also considered.
Role of Lower Eyelid Reconstruction in Complete Functional Rehabilitation
Authors: Zabunyan G. A. , Martirosyan A. A. , Baryshev A. G. , Porhanov V. A. 
Published: November 2024

Objective: To present a case of reconstruction of a full-thickness lower eyelid defect.Case report: Male patient Y. aged 71 years was admitted to the Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1 (Krasnodar, Russian Federation) with the diagnosis: cancer of skin of the lateral canthus of the left eye, T1N0M0, stage I, clinical group II. According to the medical history, the neoplasm was self-detected 5 years ago. Histology findings revealed micronodular basal cell carcinoma.After a general clinical examination, the patient underwent surgery to remove the neoplasm of the lower eyelid skin and lateral canthus and reconstruct the defect using a lateral infraorbital fat pad flap, local tissues, and a free autologous cartilage graft. The configuration of the soft tissues of the eyelid was restored. Soft tissue edema was not observed. The functional state of the lacrimal apparatus was fully preserved. The esthetics of the soft tissue was rehabilitated.Conclusions: Reconstruction in such esthetically significant area as the middle third of the face is associated with special requirements for graft formation and positioning. A gentle and functionally justified method for restoring the parameters of the tarsal plate, conjunctival sac, and lower eyelid skin ensures complete rehabilitation of patients and improves their quality of life.
Multimodal Approach (MRI and Ultrasonography) to the Diagnosis of Fetal Congenital Heart Diseases
Authors: Pomortsev A. V. , Karakhalis M. N. , Krivonosova N. V. , Goloseev K. F. 
Published: November 2024

Introduction: As the rate of congenital heart diseases (CHD) remains high, medical imaging specialists face a task of early diagnosis of CHD with minimal cost and burden to pregnant women and fetuses and need to verify the prenatal diagnosis in order to develop a strategy for managing pregnant women carrying a fetus with CHD.Objective: To optimize diagnostic measures in fetuses with CHD by comparing fetal echocardiography and cardiac magnetic resonance imaging (MRI).Materials and methods: We retrospectively evaluated findings from 35 fetal standard ultrasonography reports, 29 echocardiography reports, and 35 fetal autopsy reports (termination for medical reasons). We assessed 18 cases of CHD diagnosed by ultrasonography findings on the second screening; in 34% of the cases patients also underwent MRI at that time and a repeated procedure 30 weeks later.Results: When standard ultrasonography and an extended protocol with echocardiography were used together, diagnostic errors were 14.3%. In 85.7% of the fetuses, the findings of different imaging techniques fully coincided with the autopsy findings.Conclusions: In this cohort of pregnant women, the second screening should include more examinations to verify the diagnosis of CHD. Based on the first screening findings (increased nuchal translucency thickness and ductus venosus pulsatility index) patients should be referred to an expert for the second screening. If necessary, to verify the diagnosis of CHD ultrasonography and MRI can be combined during the third screening (34-36 weeks) in order to plan postnatal management of the newborn. The proposed algorithm for fetal CHD diagnosis enables to minimize the likelihood of error and maintain continuity of care between obstetricians-gynecologists, ultrasonographers, radiologists, neonatologists, and cardiologists.
Illustration of the Distribution of DNA Sequences and Their Frequencies Within the MEP2 Gene Across Ten Candida Species
Authors: Dawood A. A. 
Published: November 2024

Candida species have an impact on human skin health and occasionally can lead to catastrophic conditions, such as skin cancer. The nitrogen supply in growth media regulates MEP2 gene expression. MEP2 protein may regulate the amount of ammonium accessible to cells by directly affecting ammonium assimilation. Reducing MEP2 expression removed its potential to drive filamentous growth.This study aimed to examine serial imaging of the MEP2 gene with chaos game representation (CGR) and frequency chaos game representation (FCGR). In addition, the effect of mutations in Candida albicans strains on MEP2 docking with lauramine oxide (LDAO) was investigated. The MEP2 gene was selected for 10 Candida species from the National Center for Biotechnology Information to compare DNA sequences using conventional and portray methods (CGR and FCGR). The molecular docking between MEP2 and LDAO was determined using the HDOCK server.CGR findings revealed that Candida margitis, Candida orthopsilosis, Candida dubliniensis, Candida theae, and C albicans had approximately 65% of the same characteristics. According to FCGR, there was a 75% similarity between C albicans, C theae, C dubliniensis, C orthopsilosis, and C margitis. In certain strains, but not all a mutation in the conserved region of the protein caused a change in the docking residue of LDAO with MEP2.The CGR and FCGR protocols are considered practical and reliable tools for identifying protein and DNA sequence similarities. Approximately 80% of the existing algorithms for determining multiple sequence alignments are similar to traditional methods. Targeted treatment will be possible as determining MEP2 mutations is crucial for using Candida as a nitrogen source.
Occupational Rehabilitation Following Surgery for Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis
Authors: Saenko S. S. , Giller D. B. , Shcherbakova G. V. , Kesaev O. Sh. , Koroev V. V. , Martel I. I. , Enilenis I. I. , Alborova Z. V. , Smerdin S. V. , Ergeshov A. E. 
Published: November 2024

Objective: To assess the level of occupational rehabilitation among patients who underwent surgery for multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in the long-term period compared with patients who refused surgery and opted solely for conservative management.Material and methods: We analyzed long-term outcomes of surgical treatment for destructive pulmonary tuberculosis caused by MDR and XDR Mycobacterium tuberculosis in 976 patients (group 1). Furthermore, we evaluated long-term outcomes of 888 patients (group 2) who had an ineffective main chemotherapy course (regimens IV and V) or relapses after an initially effective chemotherapy course and were managed conservatively because they refused surgery.Results: One year after the surgery or surgery consultation, the complete clinical response, ie, cavity closure and elimination of bacilli (CV-, MBT-), was achieved in 99.5% of the operated patients, in contrast to only 5.3% among those who refused surgery. At the 5-year mark after the surgery/consultation, we observed the sustained effectiveness in 97.7% of the operated patients compared with only 3.2% among those who refused surgery. During the 12 years of follow-up, tuberculosis-related deaths occurred in 9 operated patients (0.8%) and 643 patients (72.4%) who refused surgery. Furthermore, 78.9% of the patients treated surgically were able to return to work in the long-term period, in contrast to only 2.6% of those who refused surgery.Conclusions: Our analysis revealed that the complete clinical response one year after the surgery/surgery consultation was 18.8 times more common in the patients who underwent surgery compared with those who refused it. Similarly, the complete clinical response 5 years after the surgery/consultation was 30.5 times higher in the operated patients. Tuberculosis-related deaths during the follow-up were 90.5 times more common among the patients who refused surgery. Furthermore, the 5-year survival rate among the operated patients was 3.3 times higher, and occupational rehabilitation was 30.3 times more common compared with those who refused surgery.
Modeling of Healing of Intra-Articular Fractures of Long Tubular Bones in Rats
Authors: Zinovkin D. A. , Nikolaev V. I. , Chueshova N. V. , Veyalkina N. N. , Ignatenko P. Yu. , Malyukov V. V. , Pranjol M. Z.I. , Zinovkina E. S. 
Published: November 2024

Background: We present a new original method of modeling an intra-articular fracture of the long tubular bone in laboratory animals.Objective: To create a new experimental model of an intra-articular fracture of the long tubular bone and to approve it for comprehensive evaluation of morphofunctional parameters of cartilage and bone healing.Materials and methods: The experiment was performed on 30 white sexually mature Wistar rats. Modeling involved layer-by-layer dissection of tissues along the anteromedial surface and formation of an incomplete fracture of the femoral medial condyle using a sharp L-shaped working end of an 0.2 × 0.2 сm instrument perpendicular to the medial condyle with a slight single muscle force. The rats were euthanized in groups of 10 animals on days 7, 14, and 30. We performed knee radiography and determined blood osteocalcin and BMP-7 levels. The Mankin score was used in the histological evaluation of the articular cartilage changes. The groups were compared using the Kruskal-Wallis test. P < .05 was considered statistically significant.Results: We noted statistically significant differences (P < .0001) when comparing the groups using the Mankin score. The post hoc test revealed statistically significant differences in the Mankin scores between days 7 and 14 (P = .014) and between days 7 and 30 (P < .0001). Group comparisons showed no statistically significant differences in blood osteocalcin levels (P = .518). However, there were statistically significant differences (P = .0028) between the groups in blood BMP-7 levels. The post hoc test revealed statistically significant differences in blood BMP-7 levels between days 7 and 14 (P = .048) and between days 14 and 30 (P = .0195).Conclusions: The developed experimental model of intra-articular fractures of long tubular bones allows for a comprehensive assessment of reparative processes of cartilage and bone tissue. The model is close to the real mechanism of pathology development.
Comprehensive Evaluation of Decellularized Dental Pulp as a New Biomaterial for Regeneration of the Pulp-Dentin Complex
Authors: Melkonian K. I. , Rusinova T. V. , Zaporozhskaya-Abramova E. S. , Solop E. A. , Kartashevskiy I. I. , Knyshova S. A. , Risovannaya O. N. 
Published: November 2024

Objective: To develop a detergent-enzymatic method and evaluate the quality of a decellularized pulp scaffold for regenerative endodontics.Materials and methods: Biomaterial and mesenchymal stem cells (MSCs) were derived from dental pulp that was obtained following third molar extraction indicated for orthodontic reasons in patients aged 14-18 years. The detergent-enzymatic method enabled to obtain a decellularized scaffold from pulp samples. The proliferative activity and viability of dental pulp-derived MSCs were assessed using trypan blue staining and XTT assay. To assess tissue response, Wistar rats underwent subcutaneous implantation of native and decellularized dental pulp. Explanted samples were stained with hematoxylin-eosin on days 7 and 14.Results: The detergent-enzymatic treatment of the dental pulp demonstrated the absence of nuclear material, whereas the histoarchitecture of the dental pulp was disturbed. The DNA content in the sample of the decellularized scaffold was 22.79 ± 2.1 ng/mg of tissue; the amount of DNA in the native sample was 78.5 ± 5.4 ng/mg of tissue. According to XTT assay results, no cytotoxicity of the decellularized scaffold against MSCs was found. Biopsy specimens of the rats with implanted decellularized dental pulp were characterized by no signs of inflammation.Conclusions: The study results will enable to create a biomaterial that can be the base of a tissue-engineered structure of the dental pulp and be used for the regeneration of the pulp-dentin complex.
Hubungan pengetahuan, perilaku, dukungan lingkungan, dan akses dengan kepatuhan konsumsi tablet tambah darah pascapandemi
Authors: Mukaromah Fitri Laila , Sitoayu Laras , Melani Vitria , Nadiyah Nadiyah , Nuzrina Rachmanida 
Published: November 2024

Latar Belakang: Anemia merupakan keadaan tubuh saat mengalami kekurangan sel darah merah dan memiliki kadar hemoglobin lebih rendah dibandingkan kadar normalnya. Prevalensi anemia pada remaja putri tahun 2018 sebesar 32%. Anemia dapat dipengaruhi oleh adanya pengetahuan, perilaku, dukungan, dan akses yang selama masa pandemi tidak didapatkan. Tujuan: Untuk mengetahui hubungan antara pengetahuan, perilaku, dukungan, dan akses dengan kepatuhan dalam mengonsumsi tablet tambah darah bagi remaja putri di SMAN 78 Jakarta pascapandemi. Metode: Penelitian ini merupakan penelitian cross sectional dengan populasi remaja putri kelas XI dan XII di SMAN 78 Jakarta. Total responden pada penelitian ini yaitu 92 siswi dari jurusan IPA, IPS, dan Bahasa yang dikumpulkan menggunakan teknik proportionate stratified random sampling. Pengumpulan data dilakukan dengan wawancara menggunakan kuesioner. Data dianalisis dmenggunakan analisis univariat, bivariat, dan multivariat. Hasil: Penelitian ini menunjukkan terdapat hubungan signifikan antara pengetahuan dengan kepatuhan (p=0,018; OR=3,545), perilaku dengan kepatuhan (p=0,0001; OR=21,667), dukungan dengan kepatuhan (p=0,013; OR=3,730), akses dengan kepatuhan (p=0,005; OR=5,229). Kesimpulan: Terdapat hubungan antara pengetahuan, perilaku, dukungan, dan akses dengan kepatuhan dalam mengonsumsi tablet tambah darah. Guru dan petugas kesehatan disarankan untuk memberikan pengetahuan mengenai anemia dan tablet tambah darah yang dimulai dari pengenalan komposisi tablet tambah darah dan anjuran dosis yang disarankan untuk mengonsumsi tablet tambah darah.
Conversor SEPIC com correção ativa de fator de potência: projeto, modelagem e simulação
Authors: Rogério Júnior Lúcio , Silva Antônio Manoel Batista da , Mrad Joaquim Welington , Dias Marcelo Costa , Alves Guilherme Henrique 
Published: November 2024

Este livro tem como objetivo apresentar os resultados extraídos de simulações computacionais de um conversor SEPIC, sendo um conversor CC-CC não isolado composto por uma saída em fase com a entrada. O projeto dos componentes eletrônicos do circuito, bem como o levantamento da função transferência (por 2 métodos) e o projeto dos compensadores são apresentados neste trabalho.	Este livro tem como objetivo proporcionar uma compreensão da modelagem e do projeto de conversores SEPIC integrando a técnica de correção ativa de fator de potência, abordando tanto os fundamentos teóricos quanto as simulações computacionais. Além de tratar de um tema importante e destacado no campo da Eletrônica de Potência, este trabalho apresenta ferramentas de modelagem e controle aplicados aos conversores CC-CC.	Espera-se que este material sirva não apenas como uma fonte de informação técnica, mas também como um estímulo à inovação e ao desenvolvimento de novas soluções tecnológicas.
Penggunaan Disiplin Ilmu Komunikasi bagi Penafsiran Alkitab dan Aplikasinya bagi Kekristenan Masa Kini
Authors: Simanjuntak Radius , Suhadi Suhadi , Simanjuntak Herbin 
Published: November 2024

This research aims to gain an understanding of the importance of using communication studies for biblical interpretation. The method used in this research is a qualitatitive descriptive method with data analysis techniques, while the type of research is literature research. Therefore, in this research the data source come from written materials related to the topics discussed such as books, articlejournals, the Bible, and other scientific works. The results of this research refer to the importance of communication science for bible interpretation. The conculusion is that with both oral and written communication, it is relatively easier for individuals to convey and receive messages from fellew individuals. In interpreting the bible it self, it is necessary to pay attention to the following element of communication studies, namely the source, message, media/method, listener/recipient of the message, and the effects/purposes resulting from the message. These elements are very important in interpreting the bible. It is the principle of communication studies that interpreters will pay attention to in order to be able to provide the right interpretation or at least that is close to the original intention of the bible writer.Penelitian ini memiliki tujuan untuk mendapatkan pemahaman mengenai pentingnya penggunaan ilmu komunikasi bagi penafsiran Alktab. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan teknik analisis data, sedangkan jenis penelitian bercorak penelitian pustaka, oleh sebab itu, dalam penelitian ini sumber-sumber data berasal dari bahan tertulis yang berkaitan dengan topik yang dibahas seperti â€“ buku, artikel, jurnal, Alkitab, maupun karya-karya ilmiah lainnya.Â Hasil penelitian ini mengacu kepada pentingnya Ilmu komunikasi bagi penafsiran Alkitab.Â Kesimpulan bahwa dengan adanya komunikasi baik lisan maupun tulisan, relatif lebih mudah bagi individu dalam menyampaikan atau menerima pesan dari sesama individu.Â Di dalam penafsiran Alkitab sendiri perlu memperhatikan beberapa elemen ilmu komunikasi berikut, yakni sumber, pesan, media/cara, pendengar/penerima pesan, dan efek/tujuan yang ditimbulkan dari pesan tersebut.Â Elemen-elemen tersebut sangat penting dalam menafsirkan Alkitab.Â Prinsip ilmu komunikasi inilah yang akan diperhatikan para penafsir untuk dapat memberikan tafsiran yang tepat, atau setidaknya yakni mendekati maksud mula-mula penulis Alkitab.
Eksplorasi Kepercayaan Orang Niniwe kepada Allah Ditinjau dari Yunus 3:1-10
Authors: Elen Maria , Ziliwu Alnodus Jamsenjos Indirwan 
Published: November 2024

There are many prophetic books to be found in the Bible, one of which is the book of Jonah. Jonah was sent by God to deliver God's judgment to the wicked city of Nineveh.Â From Jonah chapter 3, it is known that Jonah's short message instilled the Ninevites' trust in God. Previous studies on Jonah 3:1-10 have emphasized God's mercy that cancelled the punishment, and compared Nineveh's repentance with Israel's stubbornness. Using hermeneutical methods to understand the context of historical and theological narratives, this study presents a different focus, which is an exploration of the Ninevites' trust in God. The author investigates the Ninevites' belief in God and explores the meanings and implications of the beliefs presented in the text of Jonah 3:1-10. I then relate this to the broader narrative context of the Book of Jonah and compare it to elements of Old Testament theology. The results show that Jonah 3:5 is the culmination of the Ninevites' repentance that reflects their deep trust in God. The verse describes how the people of Nineveh, both adults and children, responded to the call to repentance by fasting and wearing sack. This reflected a deep change of heart and a willingness to repent collectively, from the king to the commoners. This belief was key to the restoration of the city. The implication of this study is that everyone has the opportunity to turn to God through repentance and receive forgiveness.