bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convergence Analysis of Weighted Stochastic Gradient Identification Algorithms Based on Latest‐Estimation for ARX Models
Authors: Wu Ai‐Guo , Fu Fang‐Zhou , Dong Rui‐Qi 
Published: February 2018

AbstractIn this paper, weighted stochastic gradient (WSG) algorithms for ARX models are proposed by modifying the standard stochastic gradient identification algorithms. In the proposed algorithms, the correction term is a weighting combination of the correction terms of the standard stochastic gradient (SG) algorithm in the current and last recursive steps. In addition, a latest estimation based WSG (LE‐WSG) algorithm is also established. The convergence performance of the proposed LE‐WSG algorithm is then analyzed. It is shown by a numerical example that both the WSG and LE‐WSG algorithms can possess faster convergence speed and higher convergence precision compared with the standard SG algorithms if the weighting factor is appropriately chosen.
Effects of Parent‐Implemented Early Start Denver Model Intervention on Chinese Toddlers with Autism Spectrum Disorder: A Non‐Randomized Controlled Trial
Authors: Zhou Bingrui , Xu Qiong , Li Huiping , Zhang Ying , Wang Yi , Rogers Sally J. , Xu Xiu 
Published: February 2018

To evaluate the effects of a 26‐week, high‐intensity, parent‐implemented Early Start Denver Model (P‐ESDM) intervention on developmental outcomes, severity of autism spectrum disorder (ASD), and parental stress of ASD toddlers in China. Subjects in P‐ESDM group (n = 23) were recruited from 1.5‐ to 2.5‐year‐old toddlers who were screened positive in Xuhui and Minhang Districts and were diagnosed with ASD. A community (comparison) group of age‐matched toddlers with ASD (n = 20) was recruited from other areas. Subjects of the P‐ESDM group attended 1.5‐hr parent coaching per week for 26 weeks, and those in the community group received interventions available from communities. Assessments were conducted at baseline (T1) and 26 weeks later (T2). After adjusting for baseline differences between the two groups, P‐ESDM group demonstrated greater improvement than the community group in general development, especially in Language domain. Neither group demonstrated significant change in ASD severity, but the P‐ESDM group showed greater improvement in social affect, parent‐reported social communication and symbolic play than community group did. Finally, parents in P‐ESDM group experienced decreased parenting stress while those in community group showed an opposite trend, though the differences did not reach significant association with the P‐ESDM intervention. Chinese toddlers with ASD receiving 26 weeks of P‐ESDM via regular coaching sessions showed significant greater improvement than those receiving community interventions in multiple aspects of development including social communications. These findings add support to the importance of providing early screening, diagnosis, and immediate referral for evidence‐based interventions to improve outcome of young children with ASD. Autism Res 2018, 11: 654–666. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryThe development of early screening and diagnosis of autism spectrum disorder (ASD) in China has highlighted the importance of early intervention for young children with ASD. Our current study demonstrated that parent‐implemented Early Start Denver Model (P‐ESDM) via coaching from professionals improved developmental outcomes, especially in the language domain, and social communicational behaviors of Chinese toddlers with ASD. P‐ESDM may help parents in China provide effective early intervention to their children with ASD via improving their skills when they are still at a waiting list for services or lack access to intervention, and has the potential to alleviate their parenting stress.
Split trehalase as a versatile reporter for a wide range of biological analytes
Authors: Drikic Marija , De Buck Jeroen 
Published: February 2018

AbstractIn health care, biosensors are envisioned as universal diagnostic devices with AAAA characteristics (i.e., available for anything, anywhere, anytime, to anyone). Despite numerous attempts to develop such a diagnostic device, none have managed to fulfill all four criteria and be commercialized. Glucometers, the most successful class of biosensor currently marketed monitor blood glucose concentrations. Their performance in clinical samples, including sensitivity and specificity, has been optimized and they are small and relatively inexpensive. We aimed to develop a technology that uses this existing biosensor, but adds versatility in detection of a wide range of analytes. Herein, we report the periplasmic trehalase of E. coli as a novel split enzyme reporter capable of converting a wide variety of analytes into glucose. Conditional complementation of trehalase fragments induced by detection of analytes, resulting in trehalose hydrolysis and glucose production, was used to detect antibodies and bacterial cells. We also demonstrated retention of split TreA activity in undiluted clinical samples. In conclusion, a trehalase‐based biosensor platform offers a versatile and convenient method for point‐of‐care applications as it does not require sample preparation or handling and can be integrated with existing glucometers or sensors.
Improving methyl ketone production in Escherichia coli by heterologous expression of NADH‐dependent FabG
Authors: Goh Ee‐Been , Chen Yan , Petzold Christopher J. , Keasling Jay D. , Beller Harry R. 
Published: February 2018

AbstractWe previously engineered Escherichia coli to overproduce medium‐ to long‐chain saturated and monounsaturated methyl ketones, which could potentially be applied as diesel fuel blending agents or in the flavor and fragrance industry. Recent efforts at strain optimization have focused on cofactor balance, as fatty acid‐derived pathways face the systematic metabolic challenge of net NADPH consumption (in large part, resulting from the key fatty acid biosynthetic enzyme FabG [β‐ketoacyl‐ACP reductase]) and net NADH production. In this study, we attempted to mitigate cofactor imbalance by heterologously expressing NADH‐dependent, rather than NADPH‐dependent, versions of FabG identified in previous studies. Of the four NADH‐dependent versions of FabG tested in our previously best‐reported methyl ketone‐producing strain (EGS1895), the version from Acholeplasma laidlawii (Al_FabG) showed the greatest increase in methyl ketone yield in shake flasks (35–75% higher than for an RFP negative‐control strain, depending on sugar loading). An improved strain (EGS2920) attained methyl ketone titers during fed‐batch fermentation of 5.4 ± 0.5 g/L, which were, on average, ca. 40% greater than those for the base strain (EGS1895) under fermentation conditions optimized in this study. Shotgun proteomic data for strains EGS2920 and EGS1895 during fed‐batch fermentation were consistent with the goal of alleviating NADPH limitation through expression of Al_FabG. For example, relative to strain EGS1895, strain EGS2920 significantly upregulated glucose‐6‐phosphate isomerase (directing flux into glycolysis rather than the NADPH‐producing pentose phosphate pathway) and downregulated MaeB (a NADP+‐dependent malate dehydrogenase). Overall, the results suggest that heterologous expression of NADH‐dependent FabG in E. coli may improve sustained production of fatty acid‐derived renewable fuels and chemicals.
5‐HT2CR antagonist/5‐HT2CR inverse agonist recovered the increased isolation‐induced aggressive behavior of BALB/c mice mediated by ADAR1 (p110) expression and Htr2c RNA editing
Authors: Yu Weizhi , Xu Hong , Xue Ying , An Dong , Li Huairui , Chen Wei , Yu Deqin , Sun Yiping , Ma Jianmei , Tang Yiyuan , Xiao Zhaoyang , Yin Shengming 
Published: February 2018

AbstractIntroductionSocial isolation enhances the aggressive behavior of animals, but the detailed mechanism remains unclear. Epigenetic studies have suggested that Htr2c RNA editing is closely related to aggressive behavior. This study aims to obtain a fundamental understanding of how social isolation impacts adenosine deaminase acting on RNA 1 (ADAR1, RNA editing enzyme) and Htr2c RNA editing, leading to aggressive behavior, and explore the effective solutions for the recovery of this behavior.MethodsWe evaluated 21‐day‐old BALB/c mice with and without isolation for aggressive behavior using a resident‐intruder test. Immune‐reactivity and protein expression of ADAR1 (p110) were measured using immunohistochemistry and Western blotting. Htr2c RNA editing was evaluated using pyrosequencing. In addition, the 5‐HT2CR antagonist SB243213/5‐HT2CR inverse agonist SB206553 was used to treat the isolated mice, and the performance of both treatments on the behavior, ADAR1 (p110) expression, and Htr2c RNA editing in isolated mice was examined.ResultsBoth the protein expression and immune‐reactivity of ADAR1 (p110) in the amygdala decreased, but the percentage of Htr2c RNA editing at A and B sites of amygdala only showed a moderate increase in isolated BALB/c mice with enhanced aggressive behavior compared to the age‐matched group‐housed BALB/c mice. Additionally, treatment with the 5‐HT2CR antagonist SB243213/5‐HT2CR inverse agonist SB206553 recovered the enhanced aggressive behavior of isolated mice and returned the protein expression and immune‐reactivity of ADAR1 (p110) back to the normal level. Moreover, compared to the age‐matched isolated mice treated with physiological saline, isolated mice treated with 5‐HT2CR inverse agonist SB206553 showed a lower percentage of Htr2c RNA editing at both A and B sites, and the same result occurred in isolated mice treated with 5‐HT2CR antagonist SB243213 at B site of Htr2c RNA editing.ConclusionsThe 5‐HT2CR antagonist SB243213/5‐HT2CR inverse agonist SB206553 recovered increased aggressive behavior of isolated BALB/c mice mediated by ADAR1 (p110) expression and Htr2c RNA editing.
Challenges in the diagnosis of chronic inflammatory demyelinating polyneuropathy
Authors: Allen Jeffrey A. , Gorson Kenneth C. , Gelinas Deborah 
Published: February 2018

AbstractIntroductionWe explored adherence to the European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy (CIDP) by reviewing data from a specialty pharmacy database.Materials and MethodsClinical and electrophysiologic data were reviewed for 65 consecutive patients treated with intravenous immunoglobulin (IVIG) for CIDP. Three neuromuscular neurologists independently classified cases according to EFNS/PNS criteria as (1) fulfilling CIDP criteria; (2) non‐CIDP (neither clinical nor electrophysiologic criteria met); or (3) unknown (insufficient information).ResultsPatients were treated by 31 different community neurologists in 14 states. Only seven patients (11%) met clinical and electrodiagnostic CIDP criteria. The remainder (89%) did not have CIDP (49%) or were unknown (40%). IVIG mean induction dose was 1.25 g/kg, mean maintenance dose 0.79 g/kg, and mean interval between infusions was 23 days.ConclusionsAdherence to EFNS/PNS CIDP diagnostic and treatment guidelines in the general neurologic community was poor. Improved education and awareness of widely available CIDP guidelines are recommended.
Aspirin and clopidogrel high on‐treatment platelet reactivity and genetic predictors in peripheral arterial disease
Authors: Yeo Khung‐Keong , Armstrong Ehrin J. , López Javier E. , Chen Debbie C. , Westin Gregory G. , Li Chin‐Shang , Anderson David , Hua Amy , Singapuri Anil , Amsterdam Ezra A. , Chiamvimonvat Nipavan , Laird John R. 
Published: February 2018

AbstractObjectivesOur aims were to examine the prevalence and genetic predictors of aspirin and clopidogrel high on‐treatment platelet reactivity (HoTPR), and associated adverse cardiovascular outcomes in patients with peripheral arterial disease (PAD).BackgroundThe association of aspirin and clopidogrel HoTPR with outcomes in PAD remains unclear.MethodsThis is a prospective cohort study of patients with angiographically documented PAD involving carotid and lower extremity arteries. Aspirin and clopidogrel HoTPR (using the VerifyNow Assay) and associated genetic predictors were compared to clinical outcomes. The primary end‐point was a composite of major adverse cardiovascular events: all‐cause mortality, myocardial infarction, stroke, target vessel revascularization (TVR) and limb‐loss in patients who underwent extremity intervention.ResultsThe study was stopped prematurely due to slow patient enrolment. Of 195 patients enrolled, the primary analysis was performed in 154 patients taking both drugs. Aspirin HoTPR was present in 31 (20%) and clopidogrel HoTPR in 76 (49%) patients. There was a trend toward more primary composite outcome events with PRU ≥ 235 (52% freedom‐from‐event rate vs. 70% for PRU < 235; P = 0.09). TVR was higher in those with PRU ≥ 235 (20 vs. 6%, unadjusted P = 0.02). There was no association between aspirin HoTPR and combined outcomes. Single nucleotide polymorphisms in serum paraoxonase/arylesterase 1 (PON1) gene was associated with aspirin HoTPR (P = 0.005) while SNP in phospholipase A2, group III (PLA2G3) gene was associated with clopidogrel HoTPR (P = 0.002).ConclusionClopidogrel HoTPR was significantly associated with TVR, while aspirin HoTPR was not associated with adverse clinical outcomes in patients with PAD.
Initial experience with the use of fractional flow reserve in the hemodynamic evaluation of transplant renal artery stenosis
Authors: Gomes Júnior Manuel Pereira Marques , Alves Cláudia Maria Rodrigues , Barbosa Adriano Henrique Pereira , Caixeta Adriano , Batista Marcelo Costa , Pestana José Osmar Medina , Carvalho Antônio Carlos 
Published: February 2018

AbstractObjectiveTo describe and standardize an original protocol for fractional flow reserve (FFR) pre and postangioplasty in an initial series of patients with clinically manifested transplant renal artery stenosis (TRAS).BackgroundThere is no data in the literature about the use of FFR in TRAS.MethodsPatients with TRAS detected in a noninvasive study were referred to diagnostic angiography and stenosis considered visually severe (≥ 60%) were included. After selective cannulation, a PressureWire 0.014” (Certus™—St. Jude Medical) was advanced to the distal portion of the vessel. Resting Pd/Pa ratio (ratio of mean distal to lesion and mean proximal pressures) and translesional systolic pressure gradient were obtained and FFR and hyperemic translesional systolic and mean pressure gradients (HSG and HMG) were registered after papaverine induced maximum hyperemia—pre and poststent implantation. Creatinine levels and office blood pressure measurements were registered at the baseline, 6 and 12 months after intervention.ResultsTen consecutive patients had successful stent implantation and were included. After treatment, significant increase in FFR (0.76 ± 0.09 vs. 0.96 ± 0.04, P < 0.001) and reduction in systolic hyperemic gradients (–41.40 ± 19.18, P < 0.001) and mean (–24.00 ± 11.65, P < 0.001) were observed. A strong negative correlation was observed between FFR and percent stenosis diameter—%SD (r = –0.89, P < 0.001) and HSG (r = –0.9, P < 0.001) as well as a strong positive correlation between FFR and baseline Pd/Pa ratio (r = 0.9, P < 0.001).ConclusionFFR was a well‐tolerated, valid and reproducible tool during percutaneous intervention for TRAS. Good correlation was observed between FFR and others hemodynamic parameters of lesion severity.
Diagnosis and management of rare inferior vena cava leiomyosarcoma guided by a novel minimally invasive vascular biopsy technique
Authors: Balaney Bhavna , Mitzman Brian , Fung John , Paul Jonathan D. 
Published: February 2018

AbstractPrimary vascular tumors such as vascular leiomyosarcomas are rare, but exhibit markedly different characteristics than tumors that invade the vasculature from a secondary source. Establishing a diagnosis is essential in determining the appropriate treatment plan, but obtaining a histologic specimen may prove challenging and carry significant risks. Minimally invasive endovascular biopsy techniques can be pivotal in the diagnosis—and thus in the management—of vascular tumors. We present a case of a primary inferior vena cava leiomyosarcoma, not able to be adequately assessed by noninvasive imaging and deemed too risky to be approached with traditional percutaneous biopsy techniques. Accurate diagnosis of such tumors is critical, as the success of surgical resection, although high risk, depends greatly upon the type, location, and extent of malignancy.
First report of the use of long‐tapered sirolimus‐eluting coronary stent for the treatment of chronic total occlusions with the hybrid algorithm
Authors: Zivelonghi Carlo , van Kuijk Jan P. , Nijenhuis Vincent , Poletti Enrico , Suttorp Maarten J. , van der Heyden Jan A. S. , Eefting Frank D. , Rensing Benno J. , ten Berg Jurrien M. , Azzalini Lorenzo , van den Brink Floris S. , Ribichini Flavio , Colombo Antonio , Henriques José P. S. , Agostoni Pierfrancesco 
Published: February 2018

AbstractBackgroundCoronary chronic total occlusions (CTO) usually coexist with diffusely diseased coronary segments proximal and/or distal to the CTO segment. During percutaneous treatment of CTO, multiple overlapping stents are often needed to treat these long lesions.ObjectivesAim of this study is to report the first use of long, tapered coronary sirolimus‐eluting stents (SES) in this setting.Methods and resultsThis is a retrospective analysis of 100 consecutive patients undergoing CTO recanalization following the hybrid algorithm. Procedural success rate was 89% (11 failures). Among the successful cases, “conventional” drug‐eluting stents(DES) were used in 40(44.9%) patients, while in 49(55%) patients long‐tapered SES were attempted with a success rate of 98% (1 cross‐over to regular stents). Total stent length in the long‐tapered DES group was higher compared to the “conventional” stenting group (76 ± 28 mm vs 46 ± 22 mm, P < .001), with a similar total number of stent (1.6 ± 0.8 vs 1.9 ± 0.8). At quantitative coronary analysis, proximal and distal segment involvement was more extended in patients undergoing long‐tapered stenting, with longer overall lesion length. No differences in periprocedural complications and clinical outcomes at a mean follow‐up of 303 ± 179 days were observed.ConclusionsThe use of long tapered coronary DES is technically feasible and safe for the percutaneous treatment of CTOs, especially for patients presenting with long lesions.
A retrospective study of radiation dose measurements comparing different cath lab X‐ray systems in a sample population of patients undergoing percutaneous coronary intervention for chronic total occlusions
Authors: McNeice Andrew H. , Brooks Matthew , Hanratty Colm G. , Stevenson Michael , Spratt James C. , Walsh Simon J. 
Published: February 2018

AbstractObjectivesA retrospective study was performed to investigate if the generation of X‐ray system used was an independent factor for radiation dose in chronic total occlusion (CTO) percutaneous coronary intervention (PCI).BackgroundPCI procedures for CTOs are known to be associated with higher doses of radiation. The authors suspected progressive reductions in radiation doses for CTO PCI as newer X‐ray systems were introduced into clinical practice.MethodsProcedures performed over a five‐year period by three interventional cardiologists were retrospectively reviewed. Five different X‐ray systems were used across three hospital sites. These included: Axiom Artis and Coroskop HIP (both Siemens), Innova (GE), Allura Xper FD 10, and Allura Clarity FD 10 (both Philips). Procedural and demographic data including body mass index (BMI; kg/m2), fluoroscopy time (min), and dose area product (DAP; cGycm2) were collated for each procedure. Statistical analysis was performed to compare the influence each X‐ray system would have on DAP values after BMI and fluoroscopy time were controlled for.ResultsIn total, 860 procedures were analyzed. Mean fluoroscopy time was 40.00 ± 19.99 min, mean BMI was 29.90 ± 5.13 kg/m2, mean DAP 11,980 ± 7,947 cGycm2. Log values of DAP were used to normalize results in a general linear model. A significant statistical difference in DAP between X‐ray systems was demonstrated after fluoroscopy time and BMI were controlled for (P ≤ 0.001).ConclusionThere is a significant impact on DAP values resulting from the generation of X‐ray system used, measured during PCI for CTOs, with the most modern systems producing the lowest radiation doses.
Combined mitral valve repair and heart transplantation
Authors: Sprengel Anke , Skwara Wojtek , Ziegelhöffer Tibor , Cetinkaya Ayse , Schönburg Markus , Richter Manfred 
Published: February 2018

Key Clinical MessageIn times of donor organ shortage, organs with extended allocation criteria, for example, valve pathologies, have to be taken into consideration for transplantation. The donor pool can be extended to hearts with mitral valve insufficiency. Mitral valve repair can rapidly be performed in the donor heart on the back table with excellent results.
Solitary metastasis of ampullary carcinoma to the spleen: a case report
Authors: Phan Tri M. 
Published: February 2018

Key Clinical MessageHere, we report a first case of ampullary cancer with solitary metastasis of the spleen, which was successfully treated with pancreatoduodenectomy and splenectomy and was discharged 7 days after the operation with outpatient chemotherapy. In such cases, physicians should consider splenectomy as an effective treatment option.
Triple Noncovalent‐Interaction‐Containing Supramolecular Polymer Vesicle Chemosensors with Dynamically Tunable Detection Ranges
Authors: Liu Tingting , Wang Shuodong , Li Yanran , Yan Hongxia , Tian Wei 
Published: February 2018

AbstractChemosensors (CSs) with dynamically tunable detection ranges have important significance for their expansion in practical applications; however, most CSs possess an unchangeable detection limit. In this work, we report the first example of a supramolecular polymer vesicle (SPV) chemosensor with a dynamically tunable detection range. SPVs containing porphyrin (PP) moieties and β‐cyclodextrin (β‐CD)/azobenzene (Azo) host–guest interactions were first constructed. The obtained SPVs were used to detect Zn2+ with a high selectivity and sensitivity over a wide detection limit range of 8.67×10−9 to 1.99×10−11 under UV light irradiation. The corresponding sensing mechanism was attributed to the synergistic effects of the triple noncovalent interactions, including the metal‐ligand coordination of PP/Zn2+ and the double host–guest interactions of β‐CD/Azo and β‐CD/PP.