bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toric and Phakic IOLs for the Treatment of Astigmatism and/or High Myopia: Our Experience at Prince Hashem Hospital Zarqa
Authors: Raqqad Nancy Al , Fgara Naser Al , Dros Mohammad 
Published: March 2019

Aim: to share our experience in treating patients with high myopia and or astigmatism using toric and phakic intraocular lenses at Prince Hashem Hospital in Jordan.
Patients and Methods: This is a retrospective study of fifty eyes of 36 patients who were treated between June 2015 and July 2016 at Prince Hashem Hospital in Jordan. Patients’ age ranged between 22 years and 54 years. All patients had high myopia (≥6 dipoters) and/or astigmatism and were not eligible for surface laser ablation and intolerant to contact lenses. Preoperative best corrected visual acuity BCVA, ophthalmological slit lamp examination, manifest and cycloplegic refraction, corneal topography using Oculus Pentacam and IOL master were obtained in all patients.
Results: In all the patients preoperative refraction ranged between -4 to -33 sphere and -3.5 to -8 cylinder. Phacoemulsification and implantation of toric intraocular lenses (IOL) was done in 21 patients, Visian implantable collamer lens (sphere and toric ICL) were implanted in 18 patients and toric iris claw lenses (Ophthec Artisan/ Artiflex) were used for the remaining 11 patients. All surgical procedures were done under local anesthesia. All patients showed improvement in their visual acuity after surgery and spectacle independence.
Complications were minimal in the form of lens rotation resulting in decrease in BCVA seen in 3 patients with toric IOLs and two Visian ICLs patients. High intraocular pressure was seen in one patient.
Mean follow-up period was between 6 months to 1 year.
Conclusion: Toric and phakic IOLs can be very useful in correcting astigmatism and or myopia. Proper patient selection and counseling is essential to ensure best refractive outcome and avoid complications.
Post Harvest Quality of Acid Lime Fruits 'Tahiti' Grafted on Genotype (TSKCx (LCR x TR) – 017), under Saline Stress
Authors: Sousa Sabrina Vieira de , Costa Franciscleudo Bezerra da , Silva Luderlândio De Andrade , Brito Marcos Eric Barbosa , Nascimento Ana Marinho do , Silva Jéssica Leite da , Silva Bruna Rocha da , Silva Kátia Gomes da , Santos Kalinne Passos dos , Sales Giuliana Naiara Barros , Sátiro Larissa De Sousa , Fonseca Sthelio Braga da 
Published: March 2019

Objective: The objective of this study was to verify the post-harvest quality of fruits of the acid lime fruits ‘Tahiti’ of the genotype TSKC x (LCR x TR) – 017, under saline stress.
Experimental Design: The experimental design was completely randomized from the factorial arrangement (2x5), where factor 1 corresponded to irrigation water salinity levels (0.3 and 3.0 dSm-1) and factor 2, storage time (0.5, 10, 15 and 20 days).
Location and Duration of the Study: The experiment was conducted at the Center of Science and Technology Agrifood of the Federal University of Campina Grande, Pombal Campus, Paraíba, from February 2016 to February 2017.
Methodology: The effect of the treatments was analyzed from the following evaluations: loss of fresh weight (%),soluble solids(%),titratable acidity (%),soluble solids and titratable acidity, hydrogen potential, concentration of H + ions (μM), electrical conductivity (dSm-1),ascorbic acid (mg 100 mL-1), total soluble sugars (mg 100 mL-1),phenolic compounds(mg 100 mL-1) and flavonoids (mg 100 mL-1).
Results: It was observed the interaction between the saline concentration and the time of storage, on the physical-chemical and chemical characteristics in the acid file 'Tahiti'.
Conclusion: The salinity of 3.0 dSm-1 showed the highest values for soluble solids, SS/AT ratios, total soluble sugars, phenolic compounds, and flavonoids during storage, indicating that the quality of these fruits was better when compared to fruits of the acidic 'Tahiti' file with 0.3 dSm-1 of salinity.
Comparison of the Effect of Trabeculectomy in Controlling Intraocular Pressure in Pseudo-Exfoliaiton and Primary Open Angle Glaucoma Patients
Authors: Kavuncu S. , Erbil H. H. 
Published: March 2019

Objective: The aim of this study is to compare the efficacy of the trabeculectomy in controlling intraocular pressure in patients with primary open-angle and pseudo-exfoliation glaucoma.
Materials and Methods: The medical data of a sum of 69 eyes of which 36 (52,2%) with primary open angle glaucoma (POAG) and 33 (47,8%) with pseudo-exfoliation (PEG), who have medically uncontrolled glaucoma and had undergone primary trabeculectomy in Göztepe Education and Research Hospital were evaluated in this retrospective study. Postoperatively, data at the first day, at the first month, and at the last examination evaluated in the study. Success of the surgery is defined as measurement of intraocular pressure under 21 mmHg with (incomplete success) or without (complete success) additional medications following the end of the first year follow-up examinations.
Results: POAG group consists of 36 patients of which 16 male, 20 female and PEG group consists of 33 patients of which 21 male and 12 female. The mean age was 67.2±9.1 (42-80) years in POAG group and 70.7±6.6 (55-80) years in PEG group. There was no statistically significant difference between POAG and PEG groups in visual acuity, mean intraocular pressure, c/d ratio and the number of antiglaucomatous medications preoperatively and postoperatively (p>0.05). There was a statistically significant difference in groups between post and preoperative values in visual acuity, mean intraocular pressure, c/d ratio and the number of antiglaucomatous medications (p<0.05) Success of the trabeculectomy was 41,7% (complete success), 41,7% (incomplete success) and remaining 16,6% was unsuccessful, in POAG group and success rate in PEG group was 51.5%, 27,3% and 21,2% respectively. There was no statistically significant difference between groups (p=0.738).
Conclusion: Trabeculectomy is an effective surgery in lowering intraocular pressure in both of the study groups equally.
Impact of the Gate Dielectric on Contact Resistance in High‐Mobility Organic Transistors
Authors: Paterson Alexandra F. , Mottram Alexander D. , Faber Hendrik , Niazi Muhammad R. , Fei Zhuping , Heeney Martin , Anthopoulos Thomas D. 
Published: March 2019

AbstractThe impact of the gate dielectric on contact resistance in organic thin‐film transistors (OTFTs) is investigated using electrical characterization, bias‐stress stability measurements, and bandgap density of states (DOS) analysis. Two similar dielectric materials, namely Cytop and poly[4,5‐difluoro‐2,2‐bis(trifluoromethyl)‐1,3‐dioxole‐co‐tetrafluoroethylene] (Teflon AF2400), are tested in top‐gate bottom‐contact OTFTs. The contact resistance of Cytop‐based OTFTs is found to be greater than that of the AF2400‐based devices, even though the metal/OSC interface remains identical in both systems. The Cytop devices are also found to perform worse in bias‐stress stability tests which, along with the DOS calculations, suggests that charge trapping at the OSC/dielectric interface is more prevalent with Cytop than AF2400. This increased charge trapping at the Cytop OSC/dielectric interface appears to be associated with the higher contact resistance in Cytop OTFTs. Differences in the molecular structure between Cytop and AF2400 and the large difference in the glass transition temperature of the two polymers may be responsible for the observed difference in the transistor performance. Overall, this study highlights the importance of the gate dielectric material in the quest for better performing OTFTs and integrated circuits.
The role of urban design in childhood obesity: A case study in Lisbon, Portugal
Authors: Pereira Margarida , Nogueira Helena , Padez Cristina 
Published: March 2019

AbstractObjectiveWe hypothesize that physical features of the urban environment might enhance or prevent childhood obesity. Thus, this study's main goal was to verify if there is an association between the neighborhood urban design and childhood obesity—independent of well‐known childhood obesity determinants, such as, father's level of schooling (as a proxy for socioeconomic status), and parent's weight status.MethodsThis study classifies neighborhoods according to land use and building features using hierarchical clusters analysis and examines their association with childhood obesity through logistic regression models.ResultsFour clusters resulted from the analysis: Cluster 1 represents areas with older buildings and mixed land use, cluster 2 is an area with small rented buildings and urban areas, cluster 3 comprises newer buildings with parking and urban green space, and cluster 4 is a forest area. Living in cluster 3 protects from childhood obesity, even when adjusting for father's level of schooling or parent's weight status.ConclusionsThere are distinct urban configurations in Lisbon's municipality and children who live in Cluster 3 (more recent and greener neighborhoods) seem to be protected from obesity. Therefore, public policy should focus on healthy urban planning at the neighborhood level, to promote positive impacts on peoples' health.
A Dogma in Doubt: Hydrolysis of Equatorial Ligands of PtIV Complexes under Physiological Conditions
Authors: Kastner Alexander , Poetsch Isabella , Mayr Josef , Burda Jaroslav V. , Roller Alexander , Heffeter Petra , Keppler Bernhard K. , Kowol Christian R. 
Published: March 2019

AbstractDue to their high kinetic inertness and consequently reduced side reactions with biomolecules, PtIV complexes are considered to define the future of anticancer platinum drugs. The aqueous stability of a series of biscarboxylato PtIV complexes was studied under physiologically relevant conditions. Unexpectedly and in contrast to the current chemical understanding, especially oxaliplatin and satraplatin complexes underwent fast hydrolysis in equatorial position (even in cell culture medium and serum). Notably, the resulting hydrolysis products strongly differ in their reduction kinetics, a crucial parameter for the activation of PtIV drugs, which also changes the anticancer potential of the compounds in cell culture. The discovery that intact PtIV complexes can hydrolyze at equatorial position contradicts the dogma on the general kinetic inertness of PtIV compounds and needs to be considered in the screening and design for novel platinum‐based anticancer drugs.
Comparison of male antennal morphology and sensilla physiology for sex pheromone olfactory sensing between sibling moth species: Ectropis grisescens and Ectropis obliqua (Geometridae)
Authors: Jing Liu , Zhaoqun Li , Zongxiu Luo , Xiaoming Cai , Lei Bian , Zhaojun Xin , Chen Zongmao 
Published: March 2019

AbstractEctropis grisescens and Ectropis obliqua (Lepidoptera: Geometridae) are sibling pest species that co‐occur on tea plants. The sex pheromone components of both species contain (Z,Z,Z)‐3,6,9‐octadecatriene and (Z,Z)‐3,9‐cis‐6,7‐epoxy‐octadecadiene. E. obliqua has (Z,Z)‐3,9‐cis‐6,7‐epoxy‐nonadecadiene as an additional sex pheromone component, which ensures reproductive segregation between the two species. To ascertain the detection mechanism of olfactory organs for sex pheromone components of E. grisescens and E. obliqua, we applied scanning electron microscopy and single sensillum recording to compare antennal morphology and sensillum physiology in the two species. There was no apparent morphological difference between the antennae of the two species. Both species responded similarly to all three sex pheromone components, including, E. obliqua specific component. The distribution patterns of antennal sensilla trichodea differed between the two species. Sex pheromone olfactory sensing in these sibling species appears to be determined by the density of different types of olfactory sensing neurons. Dose‐dependent responses of sensilla trichodea type 1 to (Z,Z)‐3,9‐cis‐6,7‐epoxy‐octadecadiene, the most abundant component, showed an “all or none” pattern and the other two components showed sigmoidal dose‐response curves with a half threshold of 10−4 (dilution equal to the concentration of 10 μg/μl). These results suggest that the major sex pheromone component functions as an on–off controller while secondary components function as modulators during olfactory transmission to the primary olfactory center.
Better Movers and Thinkers: An evaluation of how a novel approach to teaching physical education can impact children's physical activity, coordination and cognition
Authors: Dalziell Andrew , Booth Josephine N. , Boyle James , Mutrie Nanette 
Published: March 2019

This study aimed to identify what impact a novel approach to teaching physical education (PE) had on children's physical activity (PA), coordination and cognition compared to current provision. One hundred and fifty children were recruited from six primary schools in Scotland. Outcome measures were the Cognitive Assessment System, the Physical Activity Habits Questionnaire for Children and fundamental locomotor skills (crawling, creeping, marching and skipping). Pre‐, post‐ and 6‐month follow‐up testing was conducted and data analysed comparing a control and an intervention group. Each group received 2 hours of PE each week during the 16‐week intervention. Current provision in PE was delivered in the control group and a Better Movers and Thinkers approach to PE delivered in the intervention group. Significant effects of intervention relative to the control group were identified in cognition (p ≤ 0.001, d = 0.76) and coordination (p ≤ 0.001, d = 0.97). No significant effects of intervention were identified for PA (p ≤ 0.200, d = 0.24). The improvement in the outcome measures remained at the 6‐month follow‐up testing. The present study has identified cognitive and coordination improvements as a result of a novel PE intervention with benefits maintained 6 months later. This supports the need for modification in current PE provision to optimise the potential for learning across the curriculum.
The role of personal relevance in the value creation process of edutainment consumption
Authors: Chan Elisa K. 
Published: March 2019

AbstractThis paper explores the value creation process in an edutainment context. It attempts to capture the dual, differential value creation processes through two pathways, namely, affective and cognitive. Results revealed that affective and cognitive values not only increase customer satisfaction but also enhance consumer well‐being. Moreover, contrary to conventional belief asserting that value creation is a universal process, this study finds that those who had higher personal relevance with the edutainment context experienced more intense emotional and intellectual values, which in turn enhanced both their satisfaction, well‐being, and revisit intention. Results suggest that marketers need to rethink their engagement strategy in order to create both emotional and intellectual value for customers.
Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation
Authors: Lerchen Hans‐Georg , Stelte‐Ludwig Beatrix , Berndt Sandra , Sommer Anette , Dietz Lisa , Rebstock Anne‐Sophie , Johannes Sarah , Marx Leo , Jörißen Hannah , Mahlert Christoph , Greven Simone 
Published: March 2019

AbstractMany antibody–drug conjugates (ADCs) have failed to achieve a sufficient therapeutic window in clinical studies either due to target‐mediated or off‐target toxicities. To achieve an additional safety level, a new class of antibody–prodrug conjugates (APDCs) directed against different targets in solid tumors is here described. The tumor‐associated lysosomal endopeptidase legumain with a unique cleavage sequence was utilized for APDC metabolism. Legumain‐activatable APDCs were as potent as their cathepsin B‐activatable analogues. The peptide sequence susceptible to legumain cleavage was optimized for further discrimination of the formation of active metabolites within tumor cells versus healthy tissues, leveraging different tissue‐specific legumain activities. Optimized APDCs with slow legumain‐mediated conversion reduced preclinically the levels of active metabolite in healthy organs while retaining high activity against different TWEAKR‐ and B7H3‐expressing tumors.
An efficient virtual machine allocation algorithm for parallel and distributed simulation applications
Authors: Yao Feng , Yao Yiping , Chen Huangke , Li Tianlin , Lin Menglong , Zhang Xiaoxiong 
Published: March 2019

SummaryAllocating appropriate resource for parallel and distributed simulation (PADS) applications in clouds is an intuitive way to improve their execution efficiency. However, the heterogeneity of virtual machine (VMs) in clouds with respect to both their computing power and network latency influences the execution efficiency of PADS applications on different combinations of VMs. Besides, frequent synchronization is one of the characteristics during the execution of PADS applications, which seriously challenges the prediction of the influence of VMs' computing power and network latency on their execution efficiency, and makes allocating appropriate VMs difficult as a result. This paper first proposes a revivification‐based prediction model (ERP), which revives the execution based on statistical data from actual execution of PADS applications to predict the running time of PADS applications on different combinations of VMs. Then, an ERP‐based Allocation algorithm, namely, ERPA, is raised to optimize VMs allocation to minimize the running time of PADS applications in clouds. A series of experiments are conducted to compare the proposed ERPA with three resource allocation algorithms, ie, Gang‐scheduling‐based, Makespan‐based, and Max‐Min‐based algorithms, and the experimental results demonstrate the advantage of ERPA in improving execution efficiency of PADS applications in clouds. In particular, for communication‐sensitive PADS applications, the advantage of ERPA is more significant.
Experimental study of fire growth and ejected plume in a cross‐ventilation compartment under wind condition
Authors: Li Linjie , Gao Zihe , Ji Jie , Zhu Jiping , Wang Haobo , Zhou Dechuang 
Published: March 2019

SummaryIn this study, a set of reduced‐scale experiments were conducted to study the influence of external wind on the fire growth and ejected plume in a compartment with two openings. The approaching wind velocity was set as 1.5 and 3.0 m/s, respectively. The temperatures in the fire compartment were also measured by thermocouple matrixes. The images of the projected flames from the opening and the fuel mass loss rate were recorded by digital video and electronic balance, respectively. It is observed that the wind with velocity of 1.5 m/s can reduce the combustion severity by decreasing the ventilation in the fire room and enhance the duration time of combustion. On the contrary, the wind with velocity of 3 m/s can promote the combustion severity by increasing the ventilation in the fire room and reduce the duration time of combustion. The theoretical analysis shows how the external wind that coupled with the thermal buoyance influence the ventilation of the compartment, and a critical velocity or a dimensional number are suggested to predict the ventilation of the fire room, which is believed to influence the compartment fire behavior greatly.
Illusory own body perceptions mapped in the cingulate cortex—An intracranial stimulation study
Authors: Popa Irina , Barborica Andrei , Scholly Julia , Donos Cristian , Bartolomei Fabrice , Lagarde Stanislas , Hirsch Edouard , Valenti‐Hirsch Maria‐Paola , Maliia Mihai Dragos , Arbune Anca Adriana , Daneasa Andrei , Ciurea Jean , Bajenaru Ovidiu‐Alexandru , Mindruta Ioana 
Published: March 2019

AbstractBody awareness is the result of sensory integration in the posterior parietal cortex; however, other brain structures are part of this process. Our goal is to determine how the cingulate cortex is involved in the representation of our body. We retrospectively selected patients with drug‐resistant epilepsy, explored by stereo‐electroencephalography, that had the cingulate cortex sampled outside the epileptogenic zone. The clinical effects of high‐frequency electrical stimulation were reviewed and only those sites that elicited changes related to body perception were included. Connectivity of the cingulate cortex and other cortical structures was assessed using the h2 coefficient, following a nonlinear regression analysis of the broadband EEG signal. Poststimulation changes in connectivity were compared between two sets of stimulations eliciting or not eliciting symptoms related to body awareness (interest and control groups). We included 17 stimulations from 12 patients that reported different types of body perception changes such as sensation of being pushed toward right/left/up, one limb becoming heavier/lighter, illusory sensation of movement, sensation of pressure, sensation of floating or detachment of one hemi‐body. High‐frequency stimulation in the cingulate cortex (1 anterior, 15 middle, 1 posterior part) elicits body perception changes, associated with a decreased connectivity of the dominant posterior insula and increased coupling between other structures, located particularly in the nondominant hemisphere.
Characterization of rhizosphere bacterial community and berry quality of Hutai No.8 (Vitis vinifera L.) with different ages, and their relations
Authors: Ji Wei , Han Kai , Cai Yinghui , Mu Yuanyuan , Zhao Liang , Zhang Min , Hou Chao , Gao Meiying , Zhao Qifeng 
Published: March 2019

AbstractBACKGROUNDRhizosphere soil microbial communities play an important role in grapevine growth. However, the relationship of the rhizosphere soil bacterial community and berry quality of Hutai No.8 grape with different tree‐ages is unclear. In this work, the Biolog‐ECO technique was used to explore the functional diversity of the rhizosphere soil bacterial communities of Hutai No.8 grape with five ages (3, 5, 7, 9 and 11 years old). Meanwhile, grape berry quality indicators related to berry appearance, flavor and functional substance quality was also examined.RESULTSPrincipal component analysis of grape berry quality mainly separated 3‐year‐old (first bear fruit) and the other tree‐ages. In particular, peel weight and total soluble solid content of 3‐year‐old grape berry was significantly less than that of others. Furthermore, average well color development, species richness and Shannon's diversity index increased significantly with grapevine age. Moreover, the metabolic activities and functional diversity of soil microbial communities in using carbon sources were significantly increasing with grapevine age. Moreover, there were significant correlation between physicochemical indices of grape berry quality and six functional categories of carbon sources.CONCLUSIONTree‐ages could greatly affect the rhizosphere microbial community structure and richness, and then affect the grape berry quality. © 2019 Society of Chemical Industry