bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inter-organisational collaboration in palliative care trajectories for nursing home residents: A nation-wide mixed methods study among key persons
Authors: Hermans Sofie , Sevenants Aline , Declercq Anja , Broeck Nady V , Deliens Luc , Cohen Joachim , Audenhove Chantal V 
Published: June 2019

Introduction Multiple care organisations, such as home care services, nursing homes and hospitals, are responsible for providing an appropriate response to the palliative care needs of older people admitted into long-term care facilities. Integrated palliative care aims to provide seamless and continuous care. A possible organisational strategy to help realise integrated palliative care for this population is to create a network in which these organisations collaborate. The aim is to analyse the collaboration processes of the various organisations involved in providing palliative care to nursing home residents. Method A sequential mixed-methods study, including a survey sent to 502 participants to evaluate the collaboration between home and residential care, and between hospital and residential care, and additionally three focus group interviews involving a purposive selection among the survey participants. Participants are key persons from the nursing homes, hospitals and home care organisations that are part of the 15 Flemish palliative care networks dispersed throughout the region of Flanders, Belgium. Results Survey data were gathered from 308 key persons (response rate: 61%), and 16 people participated in three focus group interviews. Interpersonal dimensions of collaboration are rated higher than structural dimensions. This effect is statistically significant. Qualitative analyses identified guidelines, education, and information-transfer as structural challenges. Additionally, for further development, members should become acquainted and the network should prioritise the establishment of a communication infrastructure, shared leadership support and formalisation. Discussion The insights of key persons suggest the need for further structuration and can serve as a guideline for interventions directed at improving inter-organisational collaboration in palliative care trajectories for nursing home residents.
Differences in primary care providers’ and oncologists’ views on communication and coordination of care during active treatment of patients with cancer and comorbidities
Authors: P Brockway Julia , Murari Keerti , Rosenberg Alexandra , Saigh Orit , Press Matthew J , Lin Jenny J 
Published: June 2019

Introduction Management of comorbid diseases in patients with cancer is often unclear. The purpose of our study was to identify differences and similarities between primary care providers and oncologists’ knowledge, attitudes, and beliefs regarding coordination of care and comorbid disease management for patients undergoing active cancer treatment. Methods We conducted a cross-sectional study using an anonymous self-administered survey which was available to approximately 600 providers in primary care and medical oncology practicing in both outpatient and inpatient settings from March to December 2014 at three academic hospitals in New York City (Mount Sinai Hospital, Mount Sinai Beth Israel, and Weill Cornell). Our survey instrument assessed physician knowledge, attitudes, and beliefs using a clinical vignette of a cancer patient undergoing active treatment. Descriptive statistics were used to summarize the demographic and practice details of survey responses, and univariate analyses were used to assess differences in responses between primary care providers and oncologists. Results The survey was completed by 203 providers, including 127 primary care providers (62.5%), 32 medical oncologists (15.8%), 11 palliative care physicians (5.4%), and 33 nurse practitioners or physician assistants (16.3%). Medical oncologists admitted more uncertainty regarding who should manage preventive care as compared to primary care providers (34.4% vs. 16.5%, p = 0.02), whereas primary care providers were more concerned about duplicated care (22.8% vs. 6.3%, p = 0.03). Both primary care providers and medical oncologists agreed that diabetes should be actively managed during cancer treatment. More primary care providers felt less strict glycemic control was allowable (56.8% vs. 37.5%, p = 0.05) and that it is allowable for patients to miss some diabetes-related visits (80.6% vs. 56.3%, p = 0.01). Discussion Primary care providers and medical oncologists differ in their knowledge, attitudes, and beliefs regarding coordination of care and management of comorbid conditions in patients undergoing cancer treatment. These differences reflect systemic challenges to provision of care to cancer patients and the need for a model of care coordination.
Collaborative capacity and patient-centered care in the Veterans’ Health Administration Community Living Centers
Authors: Sullivan Jennifer L , Weinburg Dana Beth , Gidmark Stefanie , Engle Ryann L , Parker Victoria A , Tyler Denise A 
Published: June 2019

Introduction Previous research in acute care settings has shown that collaborative capacity, defined as the way providers collaborate as equal team members, can be improved by the ways in which an organization supports its staff and teams. This observational cross-sectional study examines the association between collaborative capacity and supportive organizational context, supervisory support, and person-centered care in nursing homes to determine if similar relationships exist. Methods We adapted the Care Coordination Survey for nursing homes and administered it to clinical staff in 20 VA Community Living Centers. We used random effects models to examine the associations between supportive organizational context, supervisory support, and person-centered care with collaborative capacity outcomes including quality of staff interactions, task independence, and collaborative influence. Results A total of 723 Community Living Center clinical staff participated in the Care Coordination Survey resulting in a response rate of 29%. We found that teamwork and collaboration—measured as task interdependence, quality of interactions and collaborative influence—did not differ significantly between Community Living Centers but did differ significantly across occupational groups. Moreover, staff members’ experiences of teamwork and collaboration were positively associated with supportive organizational context and person-centered care. Discussion Our findings suggest that elements of organizational context are important to facilitating collaborative capacity. Additionally, investing in staffing, rewards, and person-centered care may improve teamwork.
Motor speech impairment predicts expressive language in minimally verbal, but not low verbal, individuals with autism spectrum disorder
Authors: Chenausky Karen , Brignell Amanda , Morgan Angela , Tager-Flusberg Helen 
Published: June 2019

Background and aims Developmental motor speech impairment has been suspected, but rarely systematically examined, in low- and minimally verbal individuals with autism spectrum disorder. We aimed to investigate the extent of motor speech impairment in this population and its relation to number of different words produced during a semi-structured language sample. Methods Videos of 54 low-verbal and minimally verbal individuals (ages 4;4–18;10) performing portions of a speech praxis test were coded for signs of motor speech impairment (e.g., childhood apraxia of speech). Age, autism spectrum disorder severity, nonspeech oral-motor ability, speech production ability, nonverbal IQ, and receptive vocabulary were compared between groups. Results Four groups emerged: (1) speech within normal limits ( n = 12), (2) non-childhood apraxia of speech impairment ( n = 16), (3) suspected childhood apraxia of speech ( n = 13), and (4) insufficient speech to rate ( n = 13). Groups differed significantly in nonspeech oral-motor ability, speech production ability, nonverbal IQ, and receptive vocabulary. Overall, only speech production ability and receptive vocabulary accounted for significant variance in number of different words. Receptive vocabulary significantly predicted number of different words only in Groups 1 and 2, while speech production ability significantly predicted number of different words only in Groups 3 and 4. Conclusions and implications If replicated, our findings have important implications for developing much-needed spoken language interventions in minimally verbal individuals with autism spectrum disorder.
PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia
Authors: He Xin , Zhu Yinghui , Lin Yi-Chun , Li Min , Du Juan , Dong Haojie , Sun Jie , Zhu Lei , Wang Hanying , Ding Zonghui , Zhang Lei , Zhang Lianjun , Zhao Dandan , Wang Zhihao , Wu Herman , Zhang Han , Jiang Wenjuan , Xu Yang , Jin Jian , Shen Yudao , Perry Jeff , Zhao Xinyang , Zhang Bin , Liu Songbai , Xue Sheng-Li , Shen Binghui , Chen Chun-Wei , Chen Jianjun , Khaled Samer , Kuo Ya-Huei , Marcucci Guido , Luo Yun , Li Ling 
Published: June 2019

Abstract
The presence of FMS-like receptor tyrosine kinase-3 internal tandem duplication (FLT3-ITD) mutations in patients with acute myeloid leukemia (AML) is associated with poor clinical outcome. FLT3 tyrosine kinase inhibitors (TKIs), although effective in kinase ablation, do not eliminate primitive FLT3-ITD+ leukemia cells, which are potential sources of relapse. Thus, understanding the mechanisms underlying FLT3-ITD+ AML cell persistence is essential to devise future AML therapies. Here, we show that expression of protein arginine methyltransferase 1 (PRMT1), the primary type I arginine methyltransferase, is increased significantly in AML cells relative to normal hematopoietic cells. Genome-wide analysis, coimmunoprecipitation assay, and PRMT1-knockout mouse studies indicate that PRMT1 preferentially cooperates with FLT3-ITD, contributing to AML maintenance. Genetic or pharmacological inhibition of PRMT1 markedly blocked FLT3-ITD+ AML cell maintenance. Mechanistically, PRMT1 catalyzed FLT3-ITD protein methylation at arginine 972/973, and PRMT1 promoted leukemia cell growth in an FLT3 methylation–dependent manner. Moreover, the effects of FLT3-ITD methylation in AML cells were partially due to cross talk with FLT3-ITD phosphorylation at tyrosine 969. Importantly, FLT3 methylation persisted in FLT3-ITD+ AML cells following kinase inhibition, indicating that methylation occurs independently of kinase activity. Finally, in patient-derived xenograft and murine AML models, combined administration of AC220 with a type I PRMT inhibitor (MS023) enhanced elimination of FLT3-ITD+ AML cells relative to AC220 treatment alone. Our study demonstrates that PRMT1-mediated FLT3 methylation promotes AML maintenance and suggests that combining PRMT1 inhibition with FLT3 TKI treatment could be a promising approach to eliminate FLT3-ITD+ AML cells.
Unilateral L4-dorsal root ganglion stimulation evokes pain relief in chronic neuropathic postsurgical knee pain and changes of inflammatory markers: part II whole transcriptome profiling
Authors: Kinfe Thomas M. , Asif Maria , Chakravarthy Krishnan V. , Deer Timothy R. , Kramer Jeffery M. , Yearwood Thomas L. , Hurlemann Rene , Hussain Muhammad Sajid , Motameny Susanne , Wagle Prerana , Nürnberg Peter , Gravius Sascha , Randau Thomas , Gravius Nadine , Chaudhry Shafqat R. , Muhammad Sajjad 
Published: June 2019

Abstract
Background
In our recent clinical trial, increased peripheral concentrations of pro-inflammatory molecular mediators were determined in complex regional pain syndrome (CRPS) patients. After 3 months adjunctive unilateral, selective L4 dorsal root ganglion stimulation (L4-DRGSTIM), significantly decreased serum IL-10 and increased saliva oxytocin levels were assessed along with an improved pain and functional state. The current study extended molecular profiling towards gene expression analysis of genes known to be involved in the gonadotropin releasing hormone receptor and neuroinflammatory (cytokines/chemokines) signaling pathways.

Methods
Blood samples were collected from 12 CRPS patients for whole-transcriptome profiling in order to assay 18,845 inflammation-associated genes from frozen blood at baseline and after 3 months L4-DRGSTIM using PANTHER™ pathway enrichment analysis tool.

Results
Pathway enrichment analyses tools (GOrilla™ and PANTHER™) showed predominant involvement of inflammation mediated by chemokines/cytokines and gonadotropin releasing hormone receptor pathways. Further, screening of differentially regulated genes showed changes in innate immune response related genes. Transcriptomic analysis showed that 21 genes (predominantly immunoinflammatory) were significantly changed after L4-DRGSTIM. Seven genes including TLR1, FFAR2, IL1RAP, ILRN, C5, PKB and IL18 were down regulated and fourteen genes including CXCL2, CCL11, IL36G, CRP, SCGB1A1, IL-17F, TNFRSF4, PLA2G2A, CREB3L3, ADAMTS12, IL1F10, NOX1, CHIA and BDKRB1 were upregulated.

Conclusions
In our sub-group analysis of L4-DRGSTIM treated CRPS patients, we found either upregulated or downregulated genes involved in immunoinflammatory circuits relevant for the pathophysiology of CRPS indicating a possible relation. However, large biobank-based approaches are recommended to establish genetic phenotyping as a quantitative outcome measure in CRPS patients.
Trial registration The study protocol was registered at the 15.11.2016 on German Register for Clinical Trials (DRKS ID 00011267). https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00011267
Predicting Renal Cancer Recurrence: Defining Limitations of Existing Prognostic Models With Prospective Trial-Based Validation
Authors: Correa Andres F. , Jegede Opeyemi , Haas Naomi B. , Flaherty Keith T. , Pins Michael R. , Messing Edward M. , Manola Judith , Wood Christopher G. , Kane Christopher J. , Jewett Michael A.S. , Dutcher Janice P. , DiPaola Robert S. , Carducci Michael A. , Uzzo Robert G. 
Published: June 2019

PURPOSE To validate currently used recurrence prediction models for renal cell carcinoma (RCC) by using prospective data from the ASSURE (ECOG-ACRIN E2805; Adjuvant Sorafenib or Sunitinib for Unfavorable Renal Carcinoma) adjuvant trial. PATIENTS AND METHODS Eight RCC recurrence models (University of California at Los Angeles Integrated Staging System [UISS]; Stage, Size, Grade, and Necrosis [SSIGN]; Leibovich; Kattan; Memorial Sloan Kettering Cancer Center [MSKCC]; Yaycioglu; Karakiewicz; and Cindolo) were selected on the basis of their use in clinical practice and clinical trial designs. These models along with the TNM staging system were validated using 1,647 patients with resected localized high-grade or locally advanced disease (≥ pT1b grade 3 and 4/pTanyN1Mo) from the ASSURE cohort. The predictive performance of the model was quantified by assessing its discriminatory and calibration abilities. RESULTS Prospective validation of predictive and prognostic models for localized RCC showed a substantial decrease in each of the predictive abilities of the model compared with their original and externally validated discriminatory estimates. Among the models, the SSIGN score performed best (0.688; 95% CI, 0.686 to 0.689), and the UISS model performed worst (0.556; 95% CI, 0.555 to 0.557). Compared with the 2002 TNM staging system (C-index, 0.60), most models only marginally outperformed standard staging. Importantly, all models, including TNM, demonstrated statistically significant variability in their predictive ability over time and were most useful within the first 2 years after diagnosis. CONCLUSION In RCC, as in many other solid malignancies, clinicians rely on retrospective prediction tools to guide patient care and clinical trial selection and largely overestimate their predictive abilities. We used prospective collected adjuvant trial data to validate existing RCC prediction models and demonstrate a sharp decrease in the predictive ability of all models compared with their previous retrospective validations. Accordingly, we recommend prospective validation of any predictive model before implementing it into clinical practice and clinical trial design.
Increasing ergosterol levels delays formin-dependent assembly of F-actin cables and disrupts division plane positioning in fission yeast
Authors: Arbizzani Federica , Rincon Sergio A. , Paoletti Anne 
Published: June 2019

ABSTRACT
In most eukaryotes, cytokinesis is mediated by the constriction of a contractile acto-myosin ring (CR), which promotes the ingression of the cleavage furrow. Many components of the CR interact with plasma membrane lipids suggesting that lipids may regulate CR assembly and function. Although there is clear evidence that phosphoinositides play an important role in cytokinesis, much less is known about the role of sterols in this process. Here, we studied how sterols influence division plane positioning and CR assembly in fission yeast. We show that increasing ergosterol levels in the plasma membrane blocks the assembly of F-actin cables from cytokinetic precursor nodes, preventing their compaction into a ring. Abnormal F-actin cables form after a delay, leading to randomly placed septa. Since the formin Cdc12 was detected on cytokinetic precursors and the phenotype can be partially rescued by inhibiting the Arp2/3 complex, which competes with formins for F-actin nucleation, we propose that ergosterol may inhibit formin dependent assembly of F-actin cables from cytokinetic precursors.
FDTool: a Python application to mine for functional dependencies and candidate keys in tabular data
Authors: Buranosky Matt , Stellnberger Elmar , Pfaff Emily , Diaz-Sanchez David , Ward-Caviness Cavin 
Published: June 2019

Functional dependencies (FDs) and candidate keys are essential for table decomposition, database normalization, and data cleansing. In this paper, we present FDTool, a command line Python application to discover minimal FDs in tabular datasets and infer equivalent attribute sets and candidate keys from them. The runtime and memory costs associated with seven published FD discovery algorithms are given with an overview of their theoretical foundations. Previous research establishes that FD_Mine is the most efficient FD discovery algorithm when applied to datasets with many rows (> 100,000 rows) and few columns (< 14 columns). This puts it in a special position to rule mine clinical and demographic datasets, which often consist of long and narrow sets of participant records. The structure of FD_Mine is described and supplemented with a formal proof of the equivalence pruning method used. FDTool is a re-implementation of FD_Mine with additional features added to improve performance and automate typical processes in database architecture. The experimental results of applying FDTool to 13 datasets of different dimensions are summarized in terms of the number of FDs checked, the number of FDs found, and the time it takes for the code to terminate. We find that the number of attributes in a dataset has a much greater effect on the runtime and memory costs of FDTool than does row count. The last section explains in detail how the FDTool application can be accessed, executed, and further developed.
Adaptive Bands Z-Test-Statistics in Futures Markets: A New Technical Analysis Indicator
Authors: Palil Mohd Rizal 
Published: June 2019

This paper presents a study of technical analysis trading rules that generate abnormal returns for futures prices. It reports abnormal returns above that of the passive buy-and-hold policy for FKLI, FCPO, Soybean Oil Futures, Soybean Futures and Corn Futures for year 2008 tested.
A Conceptual Frame Work of Supply Chain Integration for Competitive Advantage
Authors: Ramesh Venkat , Kumar Y Vijaya , Sindhu Sindhu 
Published: June 2019

Growth as one of the key preconditions to survive in the market is forcing companies to compete on international markets and at the same time defend domestic market share from international competitors. The result of that is increased complexity of supply chains, pressure to decrease cost and improve service level. To cope with the complexity and increased customer requirements, active management of the supply chain is a prerequisite. As supply chain is a network of three or more entities directly involved in the upstream and downstream flows of products, services, finance and information from a source to a customer, management of it is a complex task.
There is significant evidence from literature that the effective implementation of integrated supply chain management (SCM) has the potential to generate significant improvements in the performance of firms. The higher levels of SCM practice can lead to enhanced competitive advantage and improved organizational performance. In order to achieve efficient supply chain integration for the processes or activities; the organizations should recognize and understand all the integration challenges of supply chain.
The aim of this paper is to investigate previous research studying the relationship between supply chain integration and performance and understand the importance of supply chain integration for competitive position of organization. Address the challenges encountered in integration of supply chain. Propose a conceptual frame work to reap the potential benefits of effective supply chain integration.
Editorial
Authors: Kumar Arti Arun 
Published: June 2019

The current issue of Ushus – Journal of Business Management is an eclectic mix of conceptual and empirical papers. The importance of conceptual papers cannot be denied as they reflect systems of concepts, assumptions, expectations, beliefs and theories as well as reflections and the various relationships between them.
In this vein, the first paper argues that albeit much technical advancement, it is the human capital that provides enough thought and stamina for any industry or institution to run. Hence, it is imperative for any organisation to take proper care of their employees. Underscoring the need for better employee care the article, A Comparative Study to Analyse the Effectiveness of Sexual Harassment Policies of IT and Non-IT Companies aims to analyse the effectiveness of sexual harassment policies of IT and Non-IT companies working in India.
The second article Getting things done, virtually! -Role of Virtual Team Leadership in Virtual Team Effectiveness highlights various dimensions of leaderships with reference to virtual teams in its review of the literature. The study’s key finding states that shared understanding is a vital force that promotes the smooth functioning of the virtual team’s performance.
The third paper stands testimony to the never-ending conflictbetween empirical papers and conceptual papers are continual. Nevertheless,it cannot be denied that empirical research enables us to operationalise a paradigm and implement it. Impact of Emotional Intelligence (EI) and Motivation on Job Satisfaction among mystery shoppers is one such empirical study. It focuses on how EI plays a mediating role between motivation and job satisfaction among mystery shoppers. The mystery shoppers may overcome negative emotions by increasing their emotional intelligence, helping them to attain greater career satisfaction.
Strategic Issues in Time Dimension of Marketing Tools in Business to Business Markets
Authors: Gopal R.K. , Raju T.V 
Published: June 2019

Key to success in serving industrial customers is to consider together the individual account, the full marketing mix, and the time. The individual account is fundamental to marketing. Marketing tools have time dimension. In general in effective marketing, the critical tools are those with time dimensions matching the time horizons of customers commitments. Long-term tools serve customers with long time horizons, whereas short term tools can support long-term tools in long-term relations.
This paper attempts to understand the various marketing tools used by an industrial marketer and their time dimension. This will help the industrial marketer to deploy the marketing tools in an effective way.