bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathomorphological picture of diabetic nephropathy in experimental diabetes mellitus
Authors: Filinova S O , Zharikov A Yu , Bobrov I P , Mazko O N , Makarova O G 
Published: February 2019

Aim. To conduct a morphological study of the renal glomerulus in experimental diabetes mellitus and to study the pathomorphological features of the development of diabetic nephropathy.
Methods. The study was carried out on 25 male Wistar rats. Modeling of diabetes mellitus was carried out by intraperitoneal injection of streptozotocin at a dose of 65 mg/kg. For more selective modeling of type 2 diabetes, the rats of the control group were intraperitoneally administered a solution of cytoflavin, calculated by the dosage of nicotinamide 115 mg/kg. In the comparison group 1 ml of physiological solution was administered in a similar manner. On day 28 of the experiment, the animals were euthanized under ether anesthesia, the kidneys were extracted, purified and washed with physiological saline. The material was fixed in a 10% neutral formalin solution. Using the morphometric method, the area of the renal glomeruli and the area of the capillary lumens were measured, and after special computer processing of digital photographs, the total area of the vascular bed in the glomerulus and the area of mesangium in the renal glomerulus were estimated.
Results. After four weeks of experiment on rats with diabetes mellitus, some characteristic changes in the morphofunctional state of renal tissues developed: an increase of the area of renal glomeruli, thickening of the basement membrane of glomerular capillaries, an increase in the size of podocytes with a decrease of their number, and foci of nephrosclerosis.
Conclusion. Based on the results of the study, characteristic pathomorphological phenomena in the kidneys of rats with experimental diabetes mellitus were recorded, which indicate the development of diabetic nephropathy.
On the features of Software Defined Networking for the QoS provision in data networks
Authors: Porras Duque Jonier Hernando , Ducuara Beltrán Daniel Orlando , Puerto Leguizamón Gustavo Adolfo 
Published: February 2019

Introduction: The traditional networks mostly implement devices where the control plane is distributed and mixed with the data plane; this fact does not allow a fast evolution towards a process that contributes to improving the transport of services. Otherwise, Software Defined Networking is a set of transport services that optimize the use of resources as these have a centralized network structure.
Objective: To determine the aspects that enable software-defined networking to provide quality of service features in data networks.
Methodology: This study is performed through network simulation over the same base network and under the same working conditions by carrying out measurements of the packet forwarding response time and management of the transported bandwidth. This study includes the demonstration of the multimedia content transport over a network architecture defining priorities to the links.
Results: The outcomes show how the Software Defined Networking achieves better management of data transmission through the base network. In the same way, the previous outcomes are reinforced with those obtained in the quality of service test performed on the streaming of a multimedia flow.
Conclusions: Due to the centralized control of Software Defined Networking, forwarding functions with the quality of service features are enabled in data networks based on layer-2 devices.
Expansión de un sistema de transmisión mediante LOPF-AC
Authors: Escudero Delgado Pablo , Carrión Galarza Diego 
Published: February 2019

Introducción: En la presente investigación se transforma las ecuaciones que conforman un OPF-AC a un sistema de restricciones lineales mediante series de Taylor, por lo cual se adquiere un modelo LOPF-AC, preciso y aplicable para poder garantizar la minimización de pérdidas en todo el sistema.
Objetivo: Minimizar las pérdidas en la expansión del sistema de transmisión.
Metodología: Se basa en linealizar las ecuaciones del OPF-AC mediante Series de Taylor, para obtener un problema linealizado.
Resultados: El modelo determina cuales son las líneas que se deberían implementar y cuales se deberían reforzar, considerando el menor costo y la minimización de las pérdidas.
Conclusiones: La demanda total de la red más la proyección de carga de los distintos casos para la expansión del sistema de transmisión es abastecida con normalidad, cumpliendo con los parámetros establecidos de generación y transmisión conjuntamente con las restricciones del algoritmo para obtener un desempeño óptimo en la TEP.
Modelado termodinámico de una planta solar térmica hibrida de ciclo Brayton en Colombia
Authors: Moreno Gamboa Faustino , Nieto Londoño Cesar 
Published: February 2019

Introducción: Actualmente en Colombia, existe gran interés por la aplicación de energías renovables y la diversificación de la matriz energética. Por lo tanto, en el presente trabajo se muestran los resultados de la simulación de una planta solar térmica hibrida de ciclo Brayton cerrado en Colombia, que recibe calor de un sistema de concentración de torre central y heliostatos. El recurso solar se estima por un modelo horario, adicionalmente cuenta con una cámara de combustión que utiliza gas natural como combustible, la cual garantiza la estabilidad del calor suministrado a la planta. La ubicación de la planta se selecciona en función de la radiación global y difusa media diaria mensual, y adicionalmente, se realiza una simulación de los principales parámetros de operación, optimizando la potencia y el rendimiento global en función de la relación de presión. Por último, se realiza un análisis exergético de la planta, especialmente de los componentes afectados por la variación de la radiación en el día.
Objetivo: Evaluar una planta solar térmica de concentración de ciclo Brayton cerrado, desde el punto de vista energético y exegético bajo las condiciones ambientales de Colombia.
Metodología: Integrar en lenguaje modélica, por medio de un compilador Dymola un modelo de recurso solar, un modelo energético y un modelo exergético aplicado a las condiciones ambientales de Colombia.
Resultados: Se presenta el análisis correspondiente a la evolución de los principales parámetros de operación de la planta a lo largo del día, la variación del rendimiento y la potencia en función de la relación de presiones.
Conclusiones: Es viable técnicamente la operación de una planta solar térmica de concentración de ciclo Brayton en algunos lugares de Colombia, dado el recurso solar disponible y el ahorro de combustible que genera a pesar del detrimento del rendimiento energético y exergético.
Peningkatan Soft Skill Siswa Melalui Pembuatan Sabun Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) di MA. Habiburrahman Jatian - Pakusari Jember
Authors: Siddiq Hadi Barru Hakam Fajar , Aditama Agnis Pondinekaria 
Published: February 2019

Community service activities undertaken by lecturers from Pharmacy Diploma III Program of Pharmacy Academy of Jember held on March, 2018, held at MA. Habiburrahman Jatian, Pakusari Jember provides benefits for students in improving students skill through soap red dragon fruit extract. MA. Habiburrahman was senior high school under the Ministry of Religious Affairs located in Jatian-Pakusari-Jember. MA. Habibirrahman also has a religious education institution that is Pondok Pesantren Habibirrahman. Nearly 70% of students of MA. Habiburrahman were santri. The results show that MA Habiburrahaman does not have a curculum that focuses on the attachment of students. Therefore, this program provides many benefits to students to add soft skills in the field of technology. In addition, this program is in great demand by all students.
Keywoard: Community Servive, Soft Skill, Soap, Red Dragon Fruit
Pembentukan Perawat Cilik (PERCIL) Sebagai Pionir Terdepan Guna Pencapaian Program Indonesia Sehat Cerdas
Authors: Wawan Haswita , Nuzula Firdawsyi 
Published: February 2019

Pembentukan Percil (perawat cilik) merupakan pendidikan kesehatan terutama mengenai pemahaman dan kesadaran akan kesehatan sejak dini. Anak usia dini sangat membutuhkan perawatan kesehatan dan memerlukan pengawasan kesehatan yang teratur agar dapat mendukung proses tumbuh kembang anak dengan baik serta menjadi sumber daya manusia yang berkualitas. Tujuan dari Pengabdian kepada Masyarakat ini adalah 1) pentingnya hidup bersih dan sehat bagi diri sendiri maupun orang lain, 2) keterampilan dalam upaya pelayanan yaitu cara-cara melakukan pertolongan pertama secara sederhana, 3) sebagai teladan, penggerak dan pendorong untuk senantiasa hidup bersih sehat. Sasaran Pengabdian kepada Masyarakat adalah kelompok siswa Taman Kanak – Kanak yaitu (1) anak yang dapat berkomunikasi dengan baik, 2) anak –anak yang sukarela ingin menjadi perawat cilik, 3) guru sebagai penganggung jawab UKS (Unit Kesehatan Sekolah). Metode Pengabdian kepada Masyarakat adalah bekerjasama dengan IGTKI Kecamatan Kalibaru yang sangat berperan dalam menginformasikan diadakannya Pengabdian Kepada Masyarakat tentang Percil (Perawat Cilik), kemudian tindak lajut kepada kepala sekolah TK Aisyiah Bustanul Athfal dan TK Nurul Husada. Sosialisasi pada mahasiswa yang ikut terlibat dalam acara ini. Pelatihan pada siswa-siswi yang didampingi oleh guru penanggung jawab UKS dari masing-masing sekolah tentang pentingnya hidup bersih dan sehat bagi diri sendiri maupun orang lain, keterampilan dalam upaya pelayanan kesehatan sederhana yaitu cara melakukan pertolongan pertama. Untuk menunjang keberhasilan acara ini, melibatkan orang tua siswa-siswa pada hari terakhir dilaksanakan pelatihan. Hasil kegiatan Pengabdian kepada Masyarakat adalah 1) Peningkatan pengetahuan siswa tentang penerapan Prilaku Hidup Bersih dan Sehat (PHBS), 2) Peningkatan keterampilan siswa dalam melakukan pertolongan pertama secara sederhana, 3) Peningkatan pengetahuan orang tua siswa tentang penerapan Prilaku Hidup Bersih dan Sehat (PHBS). Dengan Pelaksanaan Pengabdian Kepada Masyarakat harapannya semua sekolah Pendidikan Anak Usia Dini memiliki UKS dan pelayanan UKS berjalan secara optimal.
Kata Kunci: Siswa, Perawat Cilik, Sehat dan Cerdas.
Pemberdayaan Potensi Remaja Putus Sekolah di Kelurahan Ranotana Weru Manado Melalui Pelatihan Pengelolaan Sistem Informasi Kelurahan
Authors: Sendiang Maksy 
Published: February 2019

Sebagai aset yang akan menentukan nasib Bangsa Indonesia dimasa yang akan datang, potensi remaja putus sekolah harus terus digali dan dikembangkan. Meningkatnya kenakalan remaja menuntut pemerintah dan masyarakat pemerhati pada umumnya untuk tanggap terhadap apa yang menjadi kebutuhan remaja. Membekali remaja putus sekolah dengan ketrampilan yang dibutuhkan oleh pasar kerja menjadi jembatan dalam upaya mengoptimalkan potensi remaja putus sekolah dan menekan tingkat kenakalan remaja. Tulisan ini berisikan hasil penghiliran penelitian penerapan teknologi informasi dalam upaya pemberdayaan potensi masyarakat teristimewa remaja putus sekolah. Hasil penghiliran penelitian yang dikemas dalam kegiatan pengabdian pada masyarakat ini telah berdampak positip yang ditandai dengan meningkatnya kemampuan teknologi informasi remaja putus sekolah di Kelurahan Ranotana Weru Manado. Penggunaan metode pelatihan yang tepat menjadi salah satu kunci keberhasilan kegiatan pengabdian pada masyarakat ini.

Kata Kunci: kenakalan remaja, teknologi informasi, pengangguran
Prospective randomized double-blind study of efficacy and safety of 1c class antiarrhythmic agent (propafenone) for supraventricular arrhythmias in septic shock compared to amiodarone
Authors: Balik Martin , Waldauf Petr , Maly Michal , Matousek Vojtech , Brozek Tomas , Rulisek Jan , Porizka Michal , Sachl Robert , PetrBrestovansky  , Otahal Michal , Svobodova Eva , Flaksa Marek , Stach Zdenek , Pazout Jaroslav , Duska Frantisek , Smid Ondrej , Stritesky Martin 
Published: February 2019

Abstract
Background: Septic shock often leads to supraventricular arrhythmias which contribute to haemodynamic compromise. A large retrospective study in this population generated the hypothesis that propafenone could be more effective than amiodarone in achieving and maintaining sinus rhythm in new-onset supraventricular arrhythmia. Moreover, the success of cardioversion can be predicted by certain echocardiographic parameters, which can guide the decision whether to aim for rhythm or rate control.
Methods: A prospective double-blind multi-center randomized controlled trial includes patients with new-onset arrhythmia related to septic shock (2016 definition), but without severe impairment of the left ventricular ejection fraction. After baseline echocardiography, the patient will be randomised to receive a bolus and maintenance dose of either amiodarone or propafenone. The primary outcome is the proportion of patients that have achieved rhythm control at 24 hours after the start of the infusion. The secondary outcomes are the composite percentage of patients that needed rescue treatments (DC cardioversion or unblinding and cross over of the antiarrhythmics) within 24 hours, recurrence of arrhythmias, ICU mortality, 28-day and 1-year mortality. In the post-hoc analysis we plan to separately assess subgroups of patients with pulmonary hypertension and right ventricular dysfunction without left ventricular systolic dysfunction. In the exploratory part of the study we will assess whether (1.) the presence of a transmitral diastolic A wave and its higher velocity-time integral is predictive for the sustainability of mechanical sinus rhythm and whether (2.) the indexed left atrial endsystolic volume is predictive of recurrent arrhythmia.
Discussion: Amiodarone has become the first-line agent of use in almost any tachyarrhythmia in the critically ill. Nevertheless, it has a wide range of side effects and may not be the most effective drug in all circumstances. In light of this, we designed a prospective randomised controlled trial. Considering that in the observational study the restoration of sinus rhythm within 24h occurred in 74% of the amiodarone-treated patients and in 89% of patients treated with propafenone, we plan to include 200 patients to have an 80% chance to demonstrate the superiority of propafenone at p=0.05. Assuming a 10% dropout, we plan to randomize 220 patients.
Trial Registration: ClinicalTrials.gov Identifier: NCT03029169, registered on 24.1.2017.
Keywords: Supraventricular arrhythmia, septic shock, propafenone, amiodarone, intensive care.
DEep VEin Lesion OPtimisation (DEVELOP) Trial Study protocol for a randomised, assessor-blinded feasibility study of iliac vein intervention for venous leg ulcers
Authors: Aherne Thomas M , Keohane C. , Mullins M. , Black S. A. , Tang T.Y. , O’Sullivan G.J. , Walsh S. R. 
Published: February 2019

Abstract
Background: Venous leg ulceration is a widespread, debilitating pathology with high recurrence rates. Conservative treatment using graduated compression dressings may be associated with unacceptable ulcer recurrence rates. Early superficial venous ablation encourages ulcer healing and reduces recurrence. However, many of this cohort display concomitant ilio-caval stenosis, which further contributes to lower limb venous hypertension and ulceration. An approach which combines early superficial venous ablation with early treatment of ilio-caval stenotic disease may significantly improve ulcer healing and recurrence rates. We question whether early iliac vein interrogation with intravascular ultrasound (IVUS), stenting of significant occlusive disease plus superficial venous ablation, in patients with active venous leg ulceration, will produce superior ulcer healing to standard therapy.
Methods: This is a prospective, multi-centre, randomised controlled, feasibility study recruiting patients with lower limb venous ulceration and Great Saphenous incompetence. Patients will be randomised to undergo either truncal ablation and compression therapy or truncal ablation, simultaneous iliac interrogation with intravascular ultrasound and stenting of significant (>50%) iliac vein lesions plus compression therapy. The primary endpoints will be ulcer healing and procedural safety. Secondary endpoints include time to healing, quality of life and clinical scores, ulcer recurrence rates and rates of post-thrombotic syndrome. Follow up will be over a five-year period. This feasibility study is designed to include 60 patients. Should it be practicable a total of 594 patients would be required to adequately power the study to definitively address ulcer-healing rates.
Discussion: This study will be the first randomised trial to examine the role iliac interrogation and intervention in conjunction with standard operative therapy in the management of venous ulceration related to Great Saphenous incompetence.
Ethical Committee Reference: C.A. 2111 Galway Clinical Research Ethics Comittee.
Registration: Clinical Trials.gov registration NCT03640689 , Registered 21/08/2018, https://clinicaltrials.gov/ct2/show/NCT03640689.
Keywords: Venous ulcer, endovenous, deep venous intervention, iliac vein, intra-vascular ultrasound, great saphenous incompetence.
Effects of motor imagery training of gait in Parkinson´s disease: a protocol for a randomized clinical trial
Authors: Nascimento Isaíra Almeida Pereira da Silva , Santiago Lorenna , De Souza Aline Alves , Pegado Camila De Lima , Ribeiro Tatiana , Lindquist Ana Raquel 
Published: February 2019

Abstract
Background: Gait disorders in individuals with Parkinson’s Disease (PD) may be associated with alterations in the motor control system and aggravated by psychoemotional and cognitive issues. Therapeutic strategies aimed at self-perception and motor regulation seem to be promising. Motor imagery (MI) has been shown to be one of these strategies, but there is still no clear evidence of its applicability in this population. The aim of this trial is to determine the effects of motor imagery training on the gait and electroencephalographic activity of individuals with PD.
Methods: The sample consisted of 40 individuals, aged between 45 and 75 years, in the mild and moderate phase of the disease, with the ability to generate voluntary mental images. They will be assessed for cognitive level, degree of physical disability, mental image clarity, kinematic gait variables, electroencephalographic activity and mobility. Next, subjects will be randomly assigned to an experimental (EG) and control group (CG). The EG will perform motor imagery and gait, while the CG will only engage in gait exercises. Twelve training sessions will be conducted lasting up to 90 minutes each, 3 times a week, for 4 weeks. They will be reassessed on the kinematic variables of gait, electroencephalographic activity and mobility, one, seven and thirty days after the final training session.
Discussion: The results may provide an important advance in neurological rehabilitation. An easy-access and low-cost intervention may help improve gait, electroencephalographic activity and mobility in individuals with PD.
Trial Registration: Clinicaltrials.gov: NCT03439800. Registered 15 November 2017.
Keywords: Parkinson’s disease; Rehabilitation; Cerebral activation; Neurological gait disorders.
Pendampingan Komunitas Pengemis dalam Melestarikan Piwulang Kanjeng Sunan Drajat Lamongan
Authors: ULUM MIFTACHUL , Mun’im Abdul , Sholihuddin Sholihuddin 
Published: February 2019

<p>Raden Qosim or better known as Kanjeng Sunan Drajat, is present in our midst and has colored the lives of Indonesians, especially the city of Lamongan. Concern and wisdom are still felt today with the concept of Piwulang Wenehono ... Wenehono ... ..... Wenehono ...... This concept gives the meaning of the command to always give... give ... give ... ... and not asking. But in reality not all citizens are aware of and understand the implicit meanings in it, some people only take advantage and take advantage of tourist areas as part of a way to make a living regardless of the sustainability of the site of Sunan Drajat. Economic inequality is the key to dying for someone to throw themselves into a puddle of life that is not in accordance with religious norms, some people decide to become beggars. The decision to become a beggar is based on economic factors, compulsion and cultural factors of his ancestors. Beggars coloring in the world of religious tourism, regardless of whether this is appropriate or as part of helping people to do charity</p><p> </p><p>Raden Qosim, atau lebih dikenal sebagai Kanjeng Sunan Drajat, hadir di tengah-tengah kita dan telah mewarnai kehidupan orang Indonesia, khususnya kota Lamongan. Kepedulian dan kebijaksanaan masih terasa saat ini dengan konsep Piwulang Wenehono ... Wenehono .... ..... Wenehono ...... Konsep ini memberi arti perintah untuk selalu memberi..., memberi ... memberi ... ... dan bukan meminta. Tetapi pada kenyataannya tidak semua warga negara menyadari dan memahami makna implisit di dalamnya, sebagian orang hanya mengambil keuntungan dan memanfaat kawasan wisata sebagai bagian dari cara untuk mencari nafkah tanpa memperhatikan keberlangsungan situs Sunan Drajat. Kesenjangan ekonomi adalah kunci untuk mati bagi seseorang untuk melemparkan dirinya ke dalam kubangan kehidupan yang tidak sesuai dengan norma agama, sebagian orang memutuskan untuk menjadi pengemis. Keputusan menjadi pengemis didasari karena faktor ekonomi, keterpaksaan dan faktor budaya nenek moyangnya. Pengemis turut mewarnai di dunia wisata religi, tanpa memperdulikan apakah ini pantas atau sebagai bagian dari membantu orang untuk beramal</p>
PERAN OPINION LEADER DALAM SISTEM DAKWAH (Analisis Difusi Jaringan Komunikasi)
Authors: Hasanah Hasyim 
Published: February 2019

<p><em>Th</em><em>i</em><em>s paper aims to explain the role of opinion leader in dakwah activities through the analysis of communication network diffusion. This paper uses a descriptive qualitative method, with a network analysis approach. The results showed that opinion leaders playan important role in accelerating and slowing the process of diffusion of dakwah information. The higher the ability of people to influence others, the higher the effort also in influencing behavior changes that occur in that person. This is because the opinion leader has the characteristic of making himself a media through innovation into society as a social system. An opinion leader also becomes a reference for media behavior (media behavior). That is, when the opinion leader is a Dai, he is a information disseminator of dakwah information that makes himself as one of the media forming behavior to change the order of values, attitudes, and behavior of people in a systematic and structured. Double role of a Dai to achieve social system changes and realize the life of the people who Sallam, hasanah, and thayyibah, and getting of Ridho Allah SWT.</em></p><p><em>---------------------------------------------------------------------------------------</em></p><p>Tulisan ini bertujuan untuk menjelaskan peran opinion leader dalam dakwah Islam melalui analisis difusi jaringan komunikasi. Tulisan ini menggunaakan metode kualitatif deskriptif dengan pendekatan analisis jaringan. Hasil penelitian menunjukkan bahwa para pemimpin opini memegang peranan penting dalam mempercepat maupun memperlambat proses difusi informasi dakwah. Semakin tinggi kemampuan orang mempengaruhi orang lain, maka akan semakin tinggi pula usahanya dalam memengaruhi perubahan perilaku yang terjadi pada orang tersebut. Hal ini dikarenakan opinion leader memiliki karakteristik menjadikan dirinya sebagai media lewatnya inovasi ke dalam masyarakat sebagai sebuah sistem sosial. seorang opinion leader juga menjadi rujukan bagi perilaku media <em>(media behavior).</em> Artinya, ketika opinion leader adalah seorang dai, maka ia merupakan penyebar informasi dakwah yang menjadikan dirinya sebagai salah satu media pembentuk perilaku untuk mengubah tatanan nilai, sikap, dan perilaku umat secara sistematis dan terstruktur. Peran ganda seorang dai guna mencapai perubahan sistem sosial dan mewujudkan kehidupan umat yang salam, hasanah dan thayyibah serta memperoleh ridha Allah SWT.</p><p><em><br /></em></p>