bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of Brazilian jawfishes of the genus Opistognathus with descriptions of two new species (Teleostei, Opistognathidae)
Authors: Smith-Vaniz William F. , Tornabene Luke , Macieira Raphael M. 
Published: November 2018

A new species of jawfish,Opistognathusthionyisp. n., is described from the Vitória-Trindade Chain and Fernando de Noronha Archipelago off Brazil, a disjunct distribution of ca. 1,800 km.Opistognathusthionyiand its allopatric Caribbean sister-species,Opistognathusmaxillosus, both have a wide, fan-like upper margin of the subopercular flap and mostly over-lapping meristic data. The new species differs fromO.maxillosusin having the darkest spot on the spinous dorsal fin, when present, between spines 2–5, versus always present between spines 6–9, the buccal area surrounding the esophageal opening pale versus very dark and fewer oblique scale rows in longitudinal series (45–52 vs. 69–85). A second new species,Opistognathusvicinussp. n., known from Brazil’s mainland, has completely over-lapping meristic values with its allopatric Caribbean sister-speciesO.whitehursti, but differs in lacking vomerine teeth and a supramaxilla and retaining the juvenile color pattern of the latter species in adults. Diagnoses, photographs, an identification key, and distributional maps are given for all Brazilian species ofOpistognathus.Molecular phylogenetic analysis of partial cytochrome c oxidase subunit-I sequences indicates that specimens of the two allopatric pairs,O.thionyi–O.maxillosusandO.vicinus–O.whitehursti, form reciprocally monophyletic groups that differ from each other on average by 9 to 11%, with less than 1% average pair-wise genetic distance within-species. Similar patterns of phylogenetic structure were observed between reciprocally monophyletic (predominately allopatric) groups within nominal species ofOpistognathusaurifrons, suggesting the possibility of at least two additional undescribed species from the Brazilian Province.
High Incidence of Arterial and Venous Thrombosis in Antineutrophil Cytoplasmic Antibody–associated Vasculitis
Authors: Kang Amy , Antonelou Marilina , Wong Nikki L. , Tanna Anisha , Arulkumaran Nishkantha , Tam Frederick W.K. , Pusey Charles D. 
Published: November 2018

Objective.To determine the incidence of arterial thrombotic events (ATE) and venous thromboembolism (VTE) in antineutrophil cytoplasmic antibody–associated vasculitis (AAV).Methods.This is a retrospective cohort study presenting the incidence of ATE (coronary events or ischemic stroke) and VTE [pulmonary embolism (PE) or deep venous thrombosis (DVT)] in patients diagnosed with AAV between 2005 and 2014.Results.There were 204 patients with AAV who were identified. Median followup for surviving patients was 5.8 (range 1–10) years, accounting for 1088 person-years (PY). The incidence of ATE was 2.67/100 PY (1.56 for coronary events and 1.10 for ischemic stroke) and for VTE was 1.47/100 PY (0.83 for DVT only and 0.64 for PE with/without DVT). On multivariate analysis, prior ischemic heart disease (IHD) and advancing age were the only independent predictors of ATE. Among patients without prior IHD or stroke, the incidence of ATE remained elevated at 2.32/100 PY (1.26 for coronary events and 1.06 for ischemic stroke). ATE, but not VTE, was an independent predictor of all-cause mortality. Event rates for both ATE and VTE were highest in the first year after diagnosis of AAV but remained above the population incidence during the 10-year followup period. In comparison to reported rates for the UK population, the event rates in our AAV patients were 15-times higher for coronary events, 11-times higher for incident stroke, and 20-times higher for VTE.Conclusion.Patients with AAV have a high incidence of arterial and venous thrombosis, particularly in the first year after diagnosis.
Ultrasound of Subtalar Joint Synovitis in Patients with Rheumatoid Arthritis: Results of an OMERACT Reliability Exercise Using Consensual Definitions
Authors: Bruyn George A.W. , Siddle Heidi J. , Hanova Petra , Costantino Félicie , Iagnocco Annamaria , Sedie Andrea Delle , Gutierrez Marwin , Hammer Hilde B. , Jernberg Elizabeth , Loeille Damien , Micu Mihaela C. , Moller Ingrid , Pineda Carlos , Richards Bethan , Stoenoiu Maria S. , Suzuki Takeshi , Terslev Lene , Vlad Violeta , Wonink Robert , d’Agostino Maria-Antonietta , Wakefield Richard J. 
Published: November 2018

Objective.To evaluate the intraobserver and interobserver reliability of the ultrasonographic (US) assessment of subtalar joint (STJ) synovitis in patients with rheumatoid arthritis (RA).Methods.Following a Delphi process, 12 sonographers conducted an US reliability exercise on 10 RA patients with hindfoot pain. The anteromedial, posteromedial, and posterolateral STJ was assessed using B-mode and power Doppler (PD) techniques according to an agreed US protocol and using a 4-grade semiquantitative grading score for synovitis [synovial hypertrophy (SH) and signal] and a dichotomous score for the presence of joint effusion (JE). Intraobserver and interobserver reliability were computed by Cohen’s and Light’s κ. Weighted κ coefficients with absolute weighting were computed for B-mode and PD signal.Results.Mean weighted Cohen’s κ for SH, PD, and JE were 0.80 (95% CI 0.62–0.98), 0.61 (95% CI 0.48–0.73), and 0.52 (95% CI 0.36–0.67), respectively. Weighted Cohen’s κ for SH, PD, and JE in the anteromedial, posteromedial, and posterolateral STJ were −0.04 to 0.79, 0.42–0.95, and 0.28–0.77; 0.31–1, −0.05 to 0.65, and −0.2 to 0.69; 0.66–1, 0.52–1, and 0.42–0.88, respectively. Weighted Light’s κ for SH was 0.67 (95% CI 0.58–0.74), 0.46 (95% CI 0.35–0.59) for PD, and 0.16 (95% CI 0.08–0.27) for JE. Weighted Light’s κ for SH, PD, and JE were 0.63 (95% CI 0.45–0.82), 0.33 (95% CI 0.19–0.42), and 0.09 (95% CI −0.01 to 0.19), for the anteromedial; 0.49 (95% CI 0.27–0.64), 0.35 (95% CI 0.27–0.4), and 0.04 (95% CI −0.06 to 0.1) for posteromedial; and 0.82 (95% CI 0.75–0.89), 0.66 (95% CI 0.56–0.8), and 0.18 (95% CI 0.04–0.34) for posterolateral STJ, respectively.Conclusion.Using a multisite assessment, US appears to be a reliable tool for assessing synovitis of STJ in RA.
An International Delphi Survey for the Definition of New Classification Criteria for Familial Mediterranean Fever, Mevalonate Kinase Deficiency, TNF Receptor–associated Periodic Fever Syndromes, and Cryopyrin-associated Periodic Syndrome
Authors: Federici Silvia , Vanoni Federica , Ben-Chetrit Eldad , Cantarini Luca , Frenkel Joost , Goldbach-Mansky Raphaela , Gul Ahmet , Hoffman Hal , Koné-Paut Isabelle , Kuemmerle-Deschner Jasmin , Lachmann Helen J. , Martini Alberto , Obici Laura , Ozen Seza , Simon Anna , Hofer Michael , Ruperto Nicolino , Gattorno Marco 
Published: November 2018

Objective.Provisional evidence-based classification criteria for hereditary periodic fever (HPF) have been recently developed. However, no consensus on how to combine clinical criteria, laboratory tests, and results of molecular analysis has been reached. The objective of this study is to understand which variables physicians consider important for the classification of patients with HPF.Methods.Two Delphi surveys were sent to health professionals in the field of autoinflammation. In the first open survey, 124 researchers could list all the variables they consider useful for the diagnosis of each monogenic periodic fever. The variables could be of any type and each researcher could complete the survey for 1 or more diseases. In the second survey, 162 researchers were asked to select, from a list of items coming from the first survey, the 10 top variables and to rank them by assigning a score from 10 to 1.Results.The response rates to the Delphi surveys were 85% for the first session and 87% for the second. The variables selected for each disease (corresponding to the third quartile, considering the total score obtained by the variables after the second Delphi survey) were 21 for mevalonate kinase deficiency, 22 for cryopyrinopathies, 18 for familial Mediterranean fever, and 20 for tumor necrosis factor receptor–associated periodic fever syndrome. A positive genetic test reached the top rank in all the HPF.Conclusion.Our process led to the identification of those features considered the most important as candidate variables to be included in a new set of evidence-based classification criteria for HPF.
Reduced Occurrence Rate of Acute Anterior Uveitis in Ankylosing Spondylitis Treated with Golimumab — The GO-EASY Study
Authors: van Bentum Rianne E. , Heslinga Sjoerd C. , Nurmohamed Michael T. , Gerards Andreas H. , Griep Ed N. , Koehorst Charlotte B.J.M. , Kok Marc R. , Schilder Anna M. , Verhoef Marijn , van der Horst-Bruinsma Irene E. 
Published: November 2018

Objective.Acute anterior uveitis (AAU) is common in ankylosing spondylitis (AS). Golimumab (GOL), a tumor necrosis factor-α inhibitor (TNFi), has proven to be effective in the treatment of AS. To date, the effect of GOL on the incidence of AAU in AS is unknown. The objective was to study the AAU occurrence rate in patients with AS during GOL treatment and secondarily, the efficacy of GOL in daily clinical practice.Methods.The study was a multicenter prospective study in a real-world setting in patients with AS who were treated with GOL for 12 months. The occurrence of AAU was assessed in the year before the initial TNFi treatment and during GOL treatment and calculated for the period at risk for a new AAU. Measures for disease activity [Ankylosing Spondylitis Disease Activity Score (ASDAS)] and treatment response [Assessment of Spondyloarthritis international Society (ASAS20 score)] were collected.Results.In total, 93 patients (65% male, 55% TNFi-naive, 27% history of AAU) were included, with a median disease duration of 7 years and ASDAS score of 3.1. During GOL treatment, the AAU occurrence rate was reduced from 11.1 to 2.2 per 100 patient-years (rate-ratio 0.20, 95% CI 0.04–0.91). After 3 months of treatment, 41% of the patients experienced a clinically important improvement of the ASDAS score (p < 0.001) and 36% an ASDAS20 response (p < 0.001). At month 12, 49% had achieved an ASAS20 response (p < 0.001).Conclusion.In AS, the AAU occurrence rate and disease activity decreased significantly during GOL treatment. Therefore, GOL can be considered a good choice in patients with AS who need a TNFi, especially in cases of recurrent AAU. (EudraCT number: 2012-002458-21)
Permanent Discontinuation of Glucocorticoids in Polymyalgia Rheumatica Is Uncommon but May Be Enhanced by Amino Bisphosphonates
Authors: Giollo Alessandro , Rossini Maurizio , Bettili Francesco , Ghellere Francesco , Fracassi Elena , Idolazzi Luca , Gatti Davide , Viapiana Ombretta 
Published: November 2018

Objective.The duration of treatment with glucocorticoids (GC) in polymyalgia rheumatica (PMR) is often longterm. Amino bisphosphonates (N-BP) are used in PMR for the prevention of GC-induced osteoporosis, but they coulsd also have immunomodulatory properties. Whether they can be effective as an adjuvant treatment in PMR is unknown. We aimed to establish whether the use of N-BP in our PMR cohort may be associated with GC discontinuation.Methods.We conducted a retrospective review of all patients diagnosed with PMR recorded in our electronic medical notes. Cox regression analyses were used to examine the association between the use of N-BP and discontinuation of GC.Results.Data were retrieved for 385 patients (mean age 71 ± 10 yrs, 64% females, mean initial prednisone dose 19 ± 9 mg/day). The median followup time was 38 months (range 9–57); more than 60% of patients were exposed to N-BP. GC were discontinued in 47% of patients after a median time of 20 months (range 14–27), but subsequently restarted in 39%. Overall, 276/385 patients (72%) were actively treated at their last available evaluation (mean prednisone dose 4.9 ± 5.5 mg/day), while 123/205 (60%) were still receiving GC after 24 months of followup. The use of N-BP was associated with the discontinuation of GC (adjusted HR 0.66, 95% CI 0.50–0.88), independent of age, initial GC dose, and osteoporosis.Conclusion.Unlike current guidelines, longterm treatment with GC is often necessary. These preliminary data suggest that N-BP may be involved in the management of PMR.
Le vote des femmes pour Marine Le Pen
Authors: Marchand-Lagier Christèle 
Published: November 2018

Le vote des femmes en faveur du Front national s’est-il banalisé ? Qu’a-t-il de singulier ? Quelles sont les femmes qui accordent leur préférence à Marine Le Pen ? Cet article s’appuie sur le traitement de questionnaires à la sortie des urnes, recueillis dans le cadre de l’enquête ALCoV 2 , lors du deuxième tour de la Présidentielle 2017. Ces données sont mobilisées pour questionner la disparition d’un « radical right gender gap » au profit d’un « gender generation gap » qui expliquerait la propension supposée plus forte des jeunes femmes à choisir la candidate d’extrême-droite. Au-delà de l’âge et du sexe néanmoins, c’est aux différents temps de la vie des femmes qu’il convient de s’intéresser pour analyser en quoi, encore plus fréquemment que les hommes, dépendantes de leurs environnements familiaux, sociaux et professionnels, elles peuvent choisir le Front national ( fn ). Cette capacité d’attraction du fn auprès de ces catégories qui restent néanmoins les moins participantes est sans doute une des raisons de ces échecs répétés aux élections.
L’ordinaire de la violence. Un cas d’atteinte sexuelle sur mineure en milieu artistique
Authors: Trachman Mathieu 
Published: November 2018

L’ordinaire est un thème souvent mobilisé dans les études sur les violences de genre. À partir d’un cas d’atteinte sexuelle sur mineure, cet article a pour objectif d’en préciser les enjeux. Il montre en premier lieu que la notion d’ordinaire, qui signifie souvent ce qui est commun à toutes les femmes, gagne à voir son périmètre précisé : dans le cas analysé, le travail artistique, sa dimension vocationnelle, la personnalisation des relations entre professeur et étudiante, les coûts d’entrée dans le métier pour les femmes sont des éléments déterminants. Dans les études féministes, l’ordinaire désigne également les faits de violence qui caractérisent la vie quotidienne des femmes. En distinguant faits, situation et qualification, l’article montre que la qualification de violence implique un sentiment d’anormalité et une réflexivité largement absents dans les situations de violence de genre. Ce hiatus explique l’incertitude souvent inhérente à la qualification de violence et le caractère rétrospectivement énigmatique des situations de violence. L’ordinaire de la violence désigne ainsi moins une évidence occultée qu’un registre de l’expérience où les abus et les agressions sont intégrés dans le cours des choses et normalisés par les protagonistes.
Terminologie outillée et diachronie : éléments de réflexion autour d’une réconciliation
Authors: Picton Aurélie 
Published: November 2018

Longtemps considérée comme le parent pauvre des recherches en langues de spécialité, la diachronie semble aujourd’hui prendre la place qui lui est due. Néanmoins, les travaux et recherches diachroniques présentent une grande hétérogénéité tant dans leurs approches que dans les objectifs qu’ils poursuivent. Si ceci reflète la richesse des apports de la diachronie, cela indique également que l’heure semble moins au plaidoyer en faveur de cette perspective, mais plus à la réflexion autour de ce qui la caractérise lorsqu’elle est appliquée aux langues de spécialité. Dans ce contexte, nous proposons d’adopter le prisme de la terminologie textuelle pour alimenter cette réflexion. Cette approche cherche en effet depuis plusieurs années à systématiser les méthodes outillées d’analyse de la variation en corpus spécialisés et à en théoriser différents aspects, à partir de contextes réels d’application. Ces objectifs ont donc amené ce courant à questionner plusieurs « piliers » d’analyse en diachronie autour des notions de corpus, outils, experts et interprétation.
Diachrony in legal terminology: a case study on the rights of victims of crime in the EU
Authors: Peruzzo Katia 
Published: November 2018

La décision-cadre 2001/220/JAI du Conseil a été le premier acte juridique adopté par l’Union européenne à énoncer des dispositions générales concernant les victimes de la criminalité et leurs droits. Dix ans plus tard, des progrès significatifs ont été accomplis grâce à l’adoption de la directive 2012/29/UE, qui a établi des normes minimales concernant les droits, le soutien et la protection des victimes de la criminalité. Cet article présente une étude menée sur les termes commençant par l’élément de tête « right » extraits des deux actes susmentionnés. L’objectif était de déterminer si les progrès juridiques réalisés au cours d’une décennie se sont accompagnés d’une évolution de la terminologie utilisée. L’étude a révélé que, lorsque la terminologie juridique est analysée dans une perspective diachronique, différents phénomènes peuvent être observés, à savoir des cas de stabilité, de néologie formelle et de néologie totale. Les phénomènes d’évolution diachronique dans la terminologie juridique sont ensuite considérés d’un point de vue didactique pour examiner les bénéfices potentiels que les étudiants en droit, en traduction juridique et en terminologie juridique pourraient tirer de l’introduction de la dimension diachronique.
Using Digestive Fluid Biomarkers to Predict Acute Gastrointestinal Injury in Critically Ill Patients: A Pilot Study
Authors: Minhua Cheng , Tao Gao , Fengchan Xi , Wenkui Yu 
Published: November 2018

Background
Acute gastrointestinal injury is associated with significantly increased mortality in critically ill patients. However, markers for measuring acute gastrointestinal injury are neither sensitive nor specific.

Objective
To determine whether enzymes in digestive fluid are predictive of the severity of acute gastrointestinal injury.

Methods
A prospective observational study was conducted between June 2015 and December 2015 in a surgical intensive care unit. Enrolled patients were classified by acute gastrointestinal injury grade according to the 2012 European Society of Intensive Care Medicine system. Digestive fluid was collected through nasointestinal tubes and analyzed 24 hours after the diagnosis of acute gastrointestinal injury. Intestinal markers of injury (pH, interleukin 6, interleukin 10, tumor necrosis factor α, and secretory immunoglobulin A) were measured in digestive fluid.

Results
Of the 76 patients included, acute gastrointestinal injury was grade I in 41, grade II in 20, grade III in 8, and grade IV in 7. Secretory immunoglobulin A was an independent predictor of grade III acute gastrointestinal injury. When data from patients with grades I and II injury and patients with grades III and IV injury were grouped together, analysis revealed that pH, interleukin 10, and secretory immunoglobulin A were independent predictors of acute gastrointestinal failure.

Conclusions
Secretory immunoglobulin A was predictive of grade III acute gastrointestinal injury. Digestive fluid markers of injury (pH, interleukin 10, and secretory immunoglobulin A) were predictors of acute gastrointestinal failure. Further study is required to determine if other markers are specific or sensitive for acute gastrointestinal injury.
Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso
Authors: SORGHO Abel Pegdwendé , MARTINSON Jeremy James , Djigma Florencia Wendkuuni , YONLI Albert Théophane , NAGALO Bolni Marius , COMPAORE Rebeca Tégwindé , OBIRI-YEBOAH Dorcas , BIRAMA Diarra , SOMBIE Herman Karim , ZONGO Arsène Wendpagnangdé , OUATTARA Abdoul Karim , SOUBEIGA Serge Théophile R. , TRAORE Lassina , ROBERTS Lewis R. , SIMPORE Jacques 
Published: November 2018

Background/Objective: The receptors of natural killer cells "Killer Cell Immunoglobulin-Like Receptor" (KIR) regulate the activity of Natural killer cells in the innate response against viral infections. To date there is no accurate method to identify high risk groups for cirrhosis and HCC in Sub-Saharan Africa. Therefore, this investigation was undertaken to assess the association between KIR genes frequencies and chronic infection HBV infection in Burkina Faso’s population. Methods: Chronic HBV carriers and healthy patients were selected for this study. The viral load for HBV were performed to confirm the serological status for HBV of the studied cohort. In addition, SSP-PCR was used to characterize the frequencies of KIR genes.Results: The study suggested that inhibitory genes KIR2DL2, KIR2DL3 and activator gene KIR2DS2 (p˂0.001 for all and OR = 2.82; 2.48 and 3.84 respectively) might be associated with chronic stages of HBV infection. While inhibitory genes KIR3DL1 (p = 0.0018 OR = 0.49), KIR3DL2 (p = 0.005 OR = 0.40), the activator gene KIR2DS1 (p = 0.014 OR = 0.47) and the pseudo gene KIR2DP1 (p = 0.011 OR = 0.49) could be associated with immunity against HBV infection. Patients who carried the KIR3DL2 gene had a high HBV viral load compared to the rest of the study population. Conclusion: Our data showed an evidence of correlation between the propensity of developing chronic HBV infection and certain KIR gene frequencies and that KIR3DL1, KIR3DL2, KIR2DS1 and KIR2DP1 might confer a protective status against chronic HBV infection in Burkina Faso’s patients.
DEFERASIROX: OVER A DECADE OF EXPERIENCE IN THALASSEMIA
Authors: Taher Ali 
Published: November 2018

Thalassemia incorporates a broad clinical spectrum characterized by decreased or absent production of normal hemoglobin leading to decreased red blood cell survival and ineffective erythropoiesis. Chronic iron overload remains an inevitable complication resulting from regular blood transfusions (transfusion-dependent) and/or increased iron absorption (mainly non-transfusion-dependent thalassemia), requiring adequate treatment to prevent the significant associated morbidity and mortality. Iron chelation therapy has become a cornerstone in the management of thalassemia patients, leading to improvements in their outcome and quality of life. Deferasirox, an oral iron chelating agent is approved for use in transfusion dependent and non-transfusion-dependent thalassemia and has shown excellent efficacy in this setting. We herein present an updated review of the role of deferasirox in thalassemia, exploring over a decade of experience, which has documented its effectiveness and convenience; in addition to its manageable safety profile.
Keywords: iron overload, iron chelation therapy, transfusion-dependent thalassemia, non-transfusion dependent thalassemia, serum ferritin, liver iron concentration, deferasirox