bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Quinazolin-2,4-Dione Derivatives as Promising Antibacterial Agents: Synthesis, In Vitro, In Silico ADMET and Molecular Docking Approaches
Authors: Abdelmonsef Aboubakr H. , El-Naggar Mohamed , Ibrahim Amal O. A. , Abdelgeliel Asmaa S. , Shehadi Ihsan A. , Mosallam Ahmed M. , Khodairy Ahmed 
Published: November 2024

A series of new quinazolin-2,4-dione derivatives incorporating amide/eight-membered nitrogen-heterocycles 2a–c, in addition, acylthiourea/amide/dithiolan-4-one and/or phenylthiazolidin-4-one 3a–d and 4a–d. The starting compound 1 was prepared by reaction of 4-(2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-benzoyl chloride with ammonium thiocyanate and cyanoacetic acid hydrazide. The reaction of 1 with strong electrophiles, namely, o-aminophenol, o-amino thiophenol, and/or o-phenylene diamine, resulted in corresponding quinazolin-2,4-dione derivatives incorporating eight-membered nitrogen-heterocycles 2a–d. Compounds 3a–d and 4a–d were synthesized in good-to-excellent yield through a one-pot multi-component reaction (MCR) of 1 with carbon disulfide and/or phenyl isocyanate under mild alkaline conditions, followed by ethyl chloroacetate, ethyl iodide, methyl iodide, and/or concentrated HCl, respectively. The obtained products were physicochemically characterized by melting points, elemental analysis, and spectroscopic techniques, such as FT-IR, 1H-NMR, 13C-NMR, and MS. The antibacterial efficacy of the obtained eleven molecules was examined in vitro against two Gram-positive bacterial strains (Staphylococcus aureus and Staphylococcus haemolyticus). Furthermore, Computer-Aided Drug Design (CADD) was performed on the synthesized derivatives, standard drug (Methotrexate), and reported antibacterial drug with the target enzymes of bacterial strains (S. aureus and S. haemolyticus) to explain their binding mode of actions. Notably, our findings highlight compounds 2b and 2c as showing both the best antibacterial activity and docking scores against the targets. Finally, according to ADMET predictions, compounds 2b and 2c possessed acceptable pharmacokinetics properties and drug-likeness properties.
Determining the Magic Wavelength Without Modulation of the Trap Depth
Authors: Xia Jingjing , Guo Feng , Zhou Yanhua , Lu Xiaotong , Chang Hong 
Published: November 2024

In this paper, the magic wavelength of the 87Sr optical lattice clock is determined by a method that bypasses the need for lattice trap depth modulation. Instead, it relies on an additional AC Stark shift generated by a dipole beam operating near the frequency of the lattice light and oriented perpendicular to the optical lattice. The magic wavelength is inferred by measuring the AC Stark shift induced by the dipole beam as a function of its power under various frequency detunings. The effect of the dipole beam on the external states of the cold ensemble is evaluated through comparative analysis of the radial and axial sideband spectra, both with and without the dipole beam. Variations in density shift resulting from changes in external states are evaluated using comprehensive numerical calculations. By avoiding trap depth modulation, this method effectively suppresses the influence of the density shift, thereby offering a promising avenue for accurately determining the magic wavelength.
On the Hypothesis of Exact Conservation of Charged Weak Hadronic Vector Current in the Standard Model
Authors: Altarawneh Derar , Höllwieser Roman , Wellenzohn Markus 
Published: November 2024

We investigate the reliability of the conservation of the vector current (CVC) hypothesis in the neutron beta decay (n β− decay). We calculate the contribution of the phenomenological term, responsible for the CVC in the hadronic current of the n β− decay (or the CVC effect), to the neutron lifetime. We show that the CVC effect increases the neutron lifetime with a relative contribution of 8.684×10−2. This leads to the increase of the neutron lifetime by 76.4 s with respect to the world averaged value τn=880.2(1.0)s from the Particle Data Group. We show that since in the Standard Model there are no interactions that are able to cancel such a huge increase in the neutron lifetime, we have to turn to the interactions beyond the Standard Model, the contribution of which to the neutron lifetime reduces to the Fierz interference term bF only. Cancelling the CVC effect at the level of the experimental accuracy, we obtain bF=0.1219(12). If this value cannot be accepted for the Fierz interference term, the CVC effect induces irresistible problems for description and understanding of the n β− decay.
إدمان شبكات التواصل الاجتماعي: المنطلقات المفاهيمية والنظرية
Authors: Sarmini Iman 
Published: November 2024

يهدف هذا المقال إلى عرض ماله صلة باستخدام شبكات التواصل الاجتماعي منذ بدأ أنطلاقها إلى تحديد ماله صله بتحول هذا الاستخدام إلى سلوك إدماني قهري. والأثار المترتبة على هذا الاستخدام، والعوامل المساهمة في تطور الاستخدام إلى شكله المرضي، والنظريات المفسره وأليات المعالجة النفسية التي تأتي ثمارها في التعامل مع هذا النمط الإدماني.
تصنيف البيانات النوعية والكمية
Authors: Benbouzid Khaled , Belhemari Bachir 
Published: November 2024

تهدف هذه الورقة البحثية إلى إبراز دور و أهمية مرحلة من مراحل البحث العلمي وهي تصنيف البيانات الإحصائية في البحوث والدراسات، (Classification of statistical data) خاصة في مجال العلوم الاجتماعية و الإنسانية، حيث حاولنا التطرق إلى أهم المقاربات والأساليب الإحصائية التي تناولت طرق تصنيف البيانات من أجل الوصول إلى التحليل الإحصائي، وهذا من خلال تسليط الضوء على النقاط التي يتم على أساسها التصنيف الإحصائي مثل طبيعة المجتمع الإحصائي و أفراد العينة وخصائصها حيث تم التركيز على أهم نوعين في التصنيفات الإحصائية وهما تصنيف البيانات النوعية و البيانات الكمية، وتحديد أسلوب كل نوع منهما وما يتميز به عن الأخر من خصائص ومميزات.
Sustained Success: Evaluating the Enduring Effects of Leadership Training on Professional Growth
Authors: Van Der Vyver Lieza 
Published: November 2024

The focus of this longitudinal study is on the long-term effectiveness of leadership training modules on the professional growth of graduates, with a particular emphasis on the strategic management and leadership training modules in postgraduate management education programmes. The study aims to track a cohort of graduates over five years post-module completion, assessing their leadership skills, career progression, and their impact on organisational performance. The first phase of the study focused on the initial assessment of the ongoing influence of leadership training over time, highlighting the key areas of career progression. Data was collected at multiple time points—immediately post-completion, and at the 1, 2, and 5-year mark. This approach enables a comprehensive analysis of the trajectory of leadership development over time. The study employs quantitative methods, administering the same questionnaire annually to the same cohort of graduates. The consistent data collection allows for a robust comparative analysis across different years, providing insights into how the leadership training modules contribute to individual career progression and organisational outcomes over time. Initial findings revealed that six months after completing the module, 90% of respondents integrated the leadership concepts into their daily activities, with a 75% implementation rate. Additionally, 80% observed noticeable changes in job responsibilities, and 85% reported increased job satisfaction. One-year post-completion, 55% of the initial respondents participated in the study, with 29% engaging in further leadership development programs. All respondents perceived a significant improvement in job performance, and 41% received promotions or career advancement opportunities. Two years after completion, 29% of the original respondents remained employed at the organisation. Among them, 76% attributed their career advancements to the leadership module, and 80% felt confident in leading and managing teams. Additionally, 84% were satisfied with their overall career progression. Five years post-completion, only 13% of respondents remained employed, with 90% rating the module's long-term impact on their leadership abilities and career trajectory as significant. All these respondents had assumed leadership roles and rated their organisation's overall success positively. This research significantly contributes to understanding the sustained impact of leadership education and offers valuable implications for curriculum developers, educators, and organisational leaders, highlighting the importance of continuous investment in leadership development for long-term career and organisational success.
Designing an Interactive Training Workshop for Teachers who are Teaching Learners with ASD
Authors: Loubser Danette 
Published: November 2024

Teachers' experiences supporting learners with Autism Spectrum Disorder (ASD) in mainstream classrooms vary widely yet commonly teachers face various difficulties in teaching these learners. Following the inclusive education policy as envisioned in Education White Paper 6, independent primary schools are increasingly enrolling learners with ASD posing challenges for mainstream teachers. Having learners with special educational needs in mainstream classrooms, changes classroom dynamics with added responsibility towards learners with ASD. Teachers often lack knowledge of how to support learners with ASD and systemic factors influence the teaching atmosphere. To address these issues, an interactive workshop will be designed, framed around Albert Bandura’s social cognitive theory, which focuses on self-efficacy. In this study, teacher self-efficacy in teaching learners with ASD will be explored. The paradigmatic perspective of the study will be pragmatism, using an action research design with a qualitative approach to collecting data to explore the research question, of what content and learning activities should be facilitated in a teacher workshop. The action research will follow six phases. In phase one, the planning of the workshop content will be done based on a thorough literature review. Phase two will be purposive sampling to select the teachers participating in the workshop which will be conducted in a mainstream primary school. Qualifying teachers will be asked to complete a pre-workshop survey detailing their biographical profiles and experience with ASD learners. Phase three is taking action, which refers to conducting the workshop. Phase four will be the collection of data from the workshop role-plays, observations, and post-workshop survey. Thematic content analysis will be used to analyse the raw data sets. The study will contribute towards teachers’ professional development with practical, clear guidelines for mainstream teachers in supporting learners with ASD in mainstream primary classrooms.
Digital Integration Insights: Exploring Highlights and Challenges of Numeracy Lecturers in Higher Education
Authors: Nupen Dominique , Jagernath Jayseema 
Published: November 2024

The pervasive influence of digital technology continues to bring about significant changes in higher education (HE). In the case of numeracy modules, lecturers find themselves at a crossroads of tradition and innovation. Here, they must navigate a complex terrain where students require support in foundational aspects of numeracy proficiency and the rapidly changing aspects of technological innovation to prepare them for the 4th and 5th Industrial Revolutions. The Technological Pedagogical Content Knowledge (TPACK) framework and the Substitution, Augmentation, Modification, and Redefinition (SAMR) model, along with Bloom’s Digital Taxonomy and constructivist learning theories provide a valuable theoretical framework for this study to examine critical factors encountered in integrating digital technology and numeracy in the context of a South African private HE Institution. Employing a qualitative methodology, this study investigates the dynamic intersection between teaching and learning, assessment strategies, digital technologies, and numeracy education in the digital age. Fifteen semi-structured interviews explore lecturers' experiences navigating this intersection. Highlights and challenges when integrating digital technology into pedagogical strategies are identified and explored. Findings highlight the potential for integrated technologies to enhance students’ analytical thinking and develop confidence in their ability to use digital tools. Contributing factors facilitating digital technology integration, such as innovative teaching strategies, active learning methodologies, and ongoing professional development, are identified. Numerous challenges to integrating technology exist, far surpassing the number of highlights, even in the presence of facilitating factors. Challenges are linked to the nature of numeracy modules, student engagement, infrastructure, skills, time limitations, and improper use of Artificial Intelligence (AI). There is a pressing need to continuously upskill lecturers and students for success in the digital age, and for a highly intentional approach to technology integration. This study will interest a range of academic stakeholders, including lecturers, information specialists, educational technologists, and teaching and learning specialists.
Curriculum Transformation in South African Tertiary Institutions: Current Research on Narratives of Change
Authors: Huston-Pretorius Gezina Dorothea , Engelbrecht Corné , Pretorius Ockert Rudolf 
Published: November 2024

Curriculum transformation initiatives, with specific reference to the South African context, is increasingly applied in the reflection of societal changes on teaching and learning, content, and pedagogy. However, currently limited research on the presiding narratives of change and their potential impact on practices, policy, and curricula hampers tertiary education stakeholders' ability to fully evaluate and drive effective curriculum transformation. Accordingly, this study aims to provide a comprehensive overview of existing research on narratives of change in South African tertiary education, with objectives that include identifying said narratives, analysing research trends, and highlighting interventions for stakeholders to consider in curricula transformation efforts. The research methodology comprises of a bibliometric and qualitative review. The former utilises “curriculum transformation”, “South Africa”, and “higher”/”tertiary” as source concepts to identify applicable publications on the SCOPUS database, which are subsequently analysed using the VOSviewer (version 1.6.20) software. The qualitative review includes an analysis of the content of the papers in line with the narratives of change identified in the network and overlay visualisations. Through these analyses, four narratives of change are identified in the bibliometric analysis, including decolonisation, e-learning, inclusive curricula, and diversity. Key interventions for curriculum transformation include integrating African perspectives, promoting inclusive teaching practices, and leveraging Information Communication Technology (ICT) for effective e-learning. Additionally, flexible teaching methods, multilingualism, industry partnerships, and the inclusion of African knowledge systems and gender-sensitive content are essential for fostering a diverse and supportive educational environment. The contribution of this paper is centred on enabling more effective and comprehensive evaluation and analysis of existing curricula by education stakeholders and institutions, and to guide successful curriculum transformation initiatives.
Особенности типизации опасных гидрологических событий в устьях рек на примере Роны и Эбро
Authors: М.В. Исупова , М.В. Михайлова 
Published: November 2024

Устья рек сильно уязвимы к повышению уровня моря, связанному с глобальными изменениями климата, усилению штормовых нагонов, морского волнения, сопровождающихся абразией морских берегов и затоплением обширных дельтовых территорий. Поэтому опыт исследований опасных гидрологических событий речного и морского происхождения в устьях рек необходим и полезен для разработки критериев оценки опасности таких событий и их комплексной типизации. На примере крупных дельт Средиземноморского региона (Роны и Эбро) показано, что несмотря на довольно хорошую изученность подобных событий в этих устьях, нет их общей принятой типизации, а для одного и того же объекта приведены разные классификации. Опасные гидрологические события в устьях Роны и Эбро разными исследователями подразделяются как по генетическому признаку (происхождению осадков), так и по величине расходов воды, повторяемости и продолжительности наводнений, оценке воздействия на окружающую среду и жизнь человека. Опасные гидрологические события в исследуемых устьях также рассмотрены с точки зрения типизации, разрабатываемой авторами. Отмечается, что для дельт Роны и Эбро среди опасных гидрологических событий наиболее характерны стоковые, нагонные, стоково-нагонные, стоково-дождевые наводнения, а также опасные маловодья.
River mouths are highly vulnerable to sea level rise associated with global climate change, strengthening storm surges, and wave action, accompanied by abrasion of seacoasts and flooding of vast deltaic areas. Therefore, experience in studying dangerous hydrological events of river and sea origin at river mouths is necessary and useful for developing criteria for assessing the danger of such events and their comprehensive typification. Using the example of large deltas of the Mediterranean region (Rhone and Ebro), it is shown that despite a rather good study of such events at these river mouths, there is no generally accepted typification, and different classifications are given for the same object. Dangerous hydrological events at the mouths of the Rhone and Ebro rivers are subdivided by different researchers both according to genetic characteristics (the origin of precipitation) and water discharge values, frequency and duration of flood, assessment of the impact on the environment and human life. Dangerous hydrological events at the studied mouths are considered from the point of view of the typification, developted by the authors. It is noted that among the dangerous hydrological events in the Rhone and Ebro deltas the most typical are fluvial, storm surge, fluvial-storm surge, fluvial-pluvial floods, as well as dangerous droughts.
A Saliency-Aware Analog Computing In-memory with SAR-Embedded Detection Achieving 18.5% Power Reduction
Authors: Ando Shimpei , Chen Yung-Chin , Miyagi Satomi , Zhang Wenlun , Yoshioka Kentaro 
Published: November 2024

Abstract
In this paper, we introduce a saliency-aware analog computing in-memory macro to mitigate the trade-off between the accuracy and power consumption of computing in-memory (CIM) by optimizing the analog to digital converter (ADC) resolution according to the importance of input data, also known as saliency. This is realized with minimal hardware overheads using the proposed successive approximation register (SAR)-embedded saliency detection technique (S2DT), which reconfigures the capacitive digital to analog converter of the SAR ADC. Saliency is determined by the magnitude of the multiply and accumulate (MAC) values. In the saliency detector, an S2DT is used to generate a threshold, classifying saliency into three levels based on the MAC magnitude to switch the ADC resolution. The chip is fabricated in TSMC 65nm complementary metal-oxide semiconductor (CMOS) technology, achieving up to 18.5% improvement in power consumption of the ADC compared to CIM without utilizing saliency, demonstrating an accuracy of 74.6% to 83.4% on the CIFAR-10 dataset.
Indicadores higiênico-sanitários e de qualidade do leite bovino em propriedades rurais da microrregião de Frutal/MG.
Authors: Rodrigues de Azevedo Câmara Larissa , Aparecida da Silva Gleice , Maria Cândido da Silva Márcia , Ney Millan Rodrigo 
Published: November 2024

Introdução: O leite é um alimento que complementa nutricionalmente a dieta humana. No entanto, apresenta alto potencial de contaminação por microrganismos patogênicos e, devido a isto, sua produção, armazenamento, beneficiamento e distribuição são preocupações de extrema relevância do segmento leiteiro.
Objetivo: Objetivou-se avaliar a aplicabilidade das normas de higiene na ordenha e as características físico-químicas e microbiológicas do leite em pequenas e médias propriedades rurais na microrregião de Frutal/MG.
Métodos: Oito propriedades leiteiras foram avaliadas quanto ao grau de tecnificação e higiene empregados na ordenha e, quinzenalmente, durante 05 meses consecutivos, foram colhidas amostras de leite em cada propriedade para as análises laboratoriais para determinação de parâmetros de composição, higiene e sanidade animal utilizando como padrões de referências as normativas estabelecidas pelo Ministério da Agricultura, Pecuária e Abastecimento (MAPA).
Resultados: De maneira geral, as propriedades avaliadas se enquadram nas normativas do MAPA em relação aos constituintes do leite, com alterações observadas nos teores de lactose. Já em relação aos parâmetros de higiene avaliado pela análise de contagem bacteriana total (CBT) e de saúde da glândula mamária verificado através da contagem de células somáticas (CCS), quatro e seis propriedades, respectivamente, não se enquadraram nas normativas, necessitando de ajustes no sistema produtivo.
Conclusão: As propriedades leiteiras avaliadas na região de Frutal/MG de maneira geral se adequam aos parâmetros de composição preconizados pelo MAPA, com algumas alterações pontuais, necessitando de ajustes principalmente no aspecto tocante higiênico-sanitário do sistema produtivo para garantir tanto a excelência do produto in natura quanto o rendimento do derivado lácteo elaborado pelas indústrias de beneficiamento.
Anaemia in Patients with Ulcerative Colitis: Risk Factors and Therapy Optimization
Authors: Chernyshova T. Ye. , Styazhina S. N. , Valinurov A. A. , Sokolova V. V. 
Published: November 2024

Background. Iron deﬁciency or iron-deﬁciency anaemia (IDA) are some of the most common systemic complications of inﬂammatory bowel diseases (IBD). Symptoms such as fatigue, reduced ability to concentrate, as well as decreased exercise tolerance can mimic common symptoms of IBD and therefore can be easily ignored. Numerous studies have shown that anaemia is a major contributor to reduced quality of life in patients with IBD. However, the correction of anaemia can signiﬁcantly improve the quality of life of patients with IBD. Therefore, it is recommended that every patient with IBD undergo regular screening for iron deﬁciency and anaemia. If they are detected, appropriate examination and treatment should be initiated.The aim of the study was to analyse the causes of IDA and anaemia for chronic conditions in ulcerative colitis patients in Udmurtia.Material and methods. Clinical protocols, laboratory and instrumental data of 101 patients with ulcerative colitis aged from 18 to 82 years included in the «Republican register of patients with chronic inﬂammatory bowel diseases» of Udmurtia were analysed.Results of discussion. Anaemia is the most widespread systemic complication in patients with IBD, which includes ulcerative colitis. In this regard, new and improved methods of diagnosing and treating anaemia in ulcerative colitis are being searched for.