bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of Face Mask Mandates on COVID-19 Transmission in Utah
Authors: Horn Alicia C. , Shoemaker Holly E. , Keegan Lindsay T. 
Published: October 2024

Objective: Throughout the COVID-19 pandemic, the effectiveness of face mask mandates was intensely debated. The objective of this study was to describe how face mask mandates at the state, county, and local levels differed in their effectiveness in reducing the number of COVID-19 cases in the jurisdiction where the mandate was implemented and throughout Utah. Methods: We used publicly available data from the Utah Department of Health and Human Services. We calculated the effectiveness of face mask mandates ( EFm) in each local health district after 3 key mandates: the enactment of face mask mandates in Salt Lake and Summit counties (SLSC) on June 28, 2020, and June 27, 2020, respectively; the enactment of a statewide face mask mandate on November 9, 2020; and the lifting of the statewide face mask mandate on April 10, 2021. Results: Most counties in Utah had a reduction in the growth rate of COVID-19 cases after enactment of face mask mandates. We found an average 11.9% reduction in EFm after the introduction of the SLSC face mask mandates, with 8 of 13 local health districts experiencing a reduction, and an average 12.7% reduction after introduction of the statewide mandate, with 12 of 13 local health districts experiencing a reduction. After mandates were lifted, many counties had an increase in EFm. Conclusion: Face mask mandates were an effective way to reduce transmission of COVID-19 in local jurisdictions and in neighboring jurisdictions in Utah. Our evidence supports the use of face mask mandates as a way to prevent disease transmission and be better equipped to respond to future pandemics.
Procognitive Effects of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation in Major Depressive Disorder: Effets procognitifs de la D-cyclosérine en traitement complémentaire par la stimulation thêta-burst intermittente dans le trouble dépressif caractérisé
Authors: DeMayo Marilena M. , Cole Jaeden , Sohn Myren N. , Bray Signe L. , Harris Ashley D. , Patten Scott B. , McGirr Alexander 
Published: October 2024

Objective Major depressive disorder (MDD) is associated with cognitive impairments that persist despite successful treatment. Transcranial magnetic stimulation is a noninvasive treatment for MDD that is associated with small procognitive effects on working memory and executive function. We hypothesized that pairing stimulation with N-methyl-D-aspartate (NMDA) receptor agonism would enhance the effects of stimulation and its procognitive effects. Method The effect of NMDA receptor agonism (D-cycloserine, 100 mg) on cognitive performance was tested in two randomized double-blind placebo-controlled trials: (1) acute effects of in the absence of stimulation ( n = 20 healthy participants) and (2) a treatment study of individuals with MDD ( n = 50) randomized to daily intermittent theta-burst stimulation (iTBS) with placebo or D-cycloserine for 2 weeks. Cognitive function was measured using the THINC-it battery, comprised of the Perceived Deficits Questionnaire, the Choice Reaction Time, the Trail Making Test, the Digit Symbol Substitution Test, and the 1-Back tests. Results D-cycloserine had no acute effect on cognition compared to placebo. iTBS + D-cycloserine was associated with significant improvements in subjective cognitive function and correct responses on the 1-Back when compared to iTBS + placebo. Improvements in subjective cognition paralleled depressive symptoms improvement, however 1-Back improvements were not attributable to improvement in depression. Conclusions An intersectional strategy pairing iTBS with NMDA receptor agonism may restore cognitive function in MDD.
Overcoming Challenges to Adopting Smoke-Free Multi-Unit Housing Policies in a Large U.S. Metropolitan Area: Insights and Recommendations From Affected Groups in 20 Los Angeles County Cities
Authors: Marshall Lia W. , Chavez-Sosa Gladis , Gorham Gallow Tonya , Jovelle Claude , Fischbach Lori , Dang Andy , Guglielmo Dana , Holmes Aimee , Kuo Tony 
Published: October 2024

Purpose Community members and non-academic partners (“affected groups”) were asked to identify factors that can influence public support, impede adoption, and mitigate challenges related to adopting local smoke-free multi-unit housing policies. Approach A series of key informant interviews were conducted with affected groups from a large U.S. metropolitan area. Setting 20 cities in Los Angeles County without a smoke-free multi-unit housing ordinance. Participants Interviewees were recruited from affected groups with knowledge about their community’s civic and political landscape (n = 63). Method Data were collected and analyzed using thematic analysis to identify, code and compare themes. Results Most interviewees indicated civic groups, those who do not smoke, and/or groups who are educated about the negative health effects of secondhand smoke exposure would be more likely to support smoke-free multi-unit housing policies. Interviewees reported several challenges to policy adoption, including competing city priorities, public disengagement, and the cost and social burden of enforcing these ordinances. To overcome them, interviewees recommended working synergistically with local governments to build diverse coalitions, educate the public, and develop clear enforcement plans. Conclusion Insights and recommendations from affected groups in 20 U.S. cities suggest that communicating with the public and priming impacted communities to support smoke-free multi-unit housing policies are promising interventions for protecting at-risk families from secondhand smoke exposure in their homes.
Bridging the gap: Analyzing skill demands in Kuwait’s electrical engineering job market to enhance employability of graduates
Authors: Nadeem Muhammad , Oroszlányová Melinda , Lushi Ardit , Farag Wael A 
Published: October 2024

The rising number of unemployed engineers in Kuwait is a concerning trend, largely stemming from a mismatch between the skills worked on in university and the expectations of employers. The present research seeks to address this issue by examining the skill demands within the electrical engineering sector of Kuwait’s job market. Through a comprehensive analysis of over 128 job listings gathered for 6 months in 2023 from various online platforms, this study aims to pinpoint the key competencies sought by employers to enhance engineers’ employability. By bridging this gap between academia and industry, our recommendations aim to inform curriculum adjustments, enabling educational institutions to tailor engineering programs to meet national workforce needs effectively. This study’s insights are not only valuable to academia but also extend to human resources consultants and recruiters, offering crucial insights into the specific skill sets sought by employers in Kuwait’s engineering sector.
Deprescribing in hospitalized patients with cancer: A clinical pharmacist-initiated multidisciplinary intervention
Authors: Sakran Razan , Litvak Michael , Haim Nissim , Kurnik Daniel 
Published: October 2024

Purpose To examine the feasibility and utility of a clinical pharmacist-led multidisciplinary deprescribing intervention in hospitalized cancer patients. Methods We performed a retrospective cohort study among cancer patients hospitalized in oncology department who underwent a medication review by a clinical pharmacist. The pharmacist's recommendations were evaluated by a multidisciplinary team. We collected demographic and clinical information, including information on medication burden before and after intervention and number and types of deprescribing recommendations and their acceptance, and compared them among patients with different estimated life expectancies. Results During a 2-year study period, 392 patients evaluated by the clinical pharmacist received 2808 prescriptions (median, 7 per patient). The clinical pharmacist recommended deprescribing of 559 medications (19.9%; 95 CI, 18.4–21.4%), at least 1 medication in 321 patients (82%). The multidisciplinary team accepted 89.6% of deprescribing recommendations, resulting in a reduction of the medication burden by 501 medications ( P < 0.001). 12.8% of deprescriptions addressed clinically manifested adverse drug effects in 15.1% of patients. The estimation of life expectancy by the senior oncologist was reasonably accurate, but did not affect deprescribing rate. Conclusions A clinical pharmacist-led deprescribing intervention within a multidisciplinary team effectively reduces medication burden and addresses adverse drug effects in cancer patients. Deprescribing interventions should be incorporated in cancer patients at any stage of the disease.
Predictors of Successful Tobacco Cessation After Receiving an E-Cigarette Based Smoking Cessation Intervention
Authors: Pope Ian , Clark Allan , Clark Lucy , Ward Emma , Stirling Susan , Belderson Pippa , Notley Caitlin 
Published: October 2024

Introduction E-cigarettes have been shown to be effective for tobacco smoking cessation. Predicting those who are most likely to achieve smoking abstinence after receiving an e-cigarette based smoking cessation intervention could help to target interventions more efficiently. Methods A secondary analysis of baseline characteristics of 505 people who received an emergency department based smoking cessation intervention incorporating brief advice, provision of an e-cigarette starter kit and referral to stop smoking services. Gender, ethnicity, age, employment status, deprivation, partner smoking status, cigarettes per day, motivation to quit, cigarette dependence and previous e-cigarette use were assessed as predictors of abstinence. Self-reported smoking status was collected 6 months after intervention delivery. Results At 6 months 169/505 (33%) of those who received the intervention self-reported abstinence. The groups that were more likely to report having quit were females (37.4% of females vs 31.0% of males), older people (41.1% of over 50s vs 33.3% of under 35s), lighter smokers (36.4% of those who smoked less than 10 cigarettes per day vs 30.7% for those who smoked over 20) and more motivated quitters (35.6% for those with high motivation vs 29.2% for those with low motivation). However, in multiple logistic regression, when adjusting for the other factors, no factors significantly predicted smoking abstinence. Degree of nicotine dependence was very similar between those who quit and those who did not. Conclusion The study found no baseline factors that could predict successful smoking cessation with e-cigarettes. Consequently, this study does not support the use of a targeted e-cigarette-based smoking cessation intervention, suggesting the adoption of a more universal approach.
Parenting a child with attention deficit hyperactivity disorder: Jordanian’s perspectives
Authors: Harb Eman M , Obieat Hanan D AL , Hamdan-Mansour Ayman M 
Published: October 2024

Raising your child with attention deficit hyperactivity disorder (ADHD) in Jordan is a challenge due to the prevailing behavioral concerns, low availability of specialized care, and generalized feelings of social stigma. This phenomenological study involved twelve Jordanian parents of children aged 4–14 years, all diagnosed with ADHD according to DSM-IV-TR criteria. Participants were recruited through purposive sampling, and semi-structured interviews were conducted. Thematic analysis revealed three key themes: “The Journey through ADHD,” in which parents recognized the abnormalities of their children, reported suffering during the diagnosis, and described a wide range of uncertainty regarding the diagnosis and treatments. The second theme was “Disease as part of life,” where parents reported the impact on family dynamics and social life. The third theme was “Caregiving burden,” reflecting physical and emotional exhaustion and financial burden. Jordanian parents caring for children with ADHD face several challenges, including physical, emotional, economic, and social challenges and limited access to specialized services. Identifying their unique needs and challenges is essential in supporting them, providing appropriate services and resources, and developing policies and guidelines for culturally competent quality services.
Prevalence, incidence, and characteristics of autism spectrum disorder among children in Beijing, China
Authors: Zhao Yanan , Lu Feng , Ding Ruoxi , Zhu Dawei , Zhang Rong , Sun Siwei , He Ping , Zheng Xiaoying 
Published: October 2024

The prevalence of autism spectrum disorder in the world has increased over the last decade, but the prevalence, incidence, and characteristics of autism spectrum disorder in China were not well understood. Using administrative data, we aimed to estimate the prevalence and incidence of autism spectrum disorder and describe the co-occurring conditions in preschoolers in Beijing, China. The study focused on 0- to 6-year-old children with registered residence in Beijing, using cohorts derived from the Beijing Municipal Health Big Data and Policy Research Center. We conducted a detailed analysis of autism spectrum disorder prevalence among the cohorts, comparing estimates across 2 to 3 years for the same birth cohort (4 years, 5 years). For the 6-year-old cohort, we obtained 1-year prevalence estimates in 2021. Annual incidence rate was also calculated. The prevalence in 6-year-old children in 2021 was 10.5 per 1000 (95% confidence interval = 9.7–10.9). The male-to-female prevalence ratio was 4.3. Between 40% and 43% of preschool children had at least one co-occurring condition. The incidence for children 6 years old and under was 0.11% in 2019 and increased to 0.18% in 2021. Both the prevalence and incidence rates in Beijing were comparable to those reported in developed countries. Lay abstract It is the first study to explore the prevalence, incidence, and co-occurring conditions of autism spectrum disorder for the preschoolers in China. The prevalence and incidence of autism spectrum disorder has increased in recent decades. Autism spectrum disorder has become an important public concern worldwide. In this study, all hospital confirmed cases had an associated diagnosis (International Classification of Diseases, 10th revision (ICD-10) codes: F84.0, 84.5, F84.9). In total, 4457 children aged 4–6 years were identified as having autism spectrum disorder. In 2021, 1 in 95 children aged 6 years, 1 in 115 children aged 5 years, and 1 in 130 children aged 4 years were estimated to have autism spectrum disorder in Beijing. The incidence was 0.11% in 2019 and increased to 0.18% in 2021. There has been a great emphasis on the importance of early autism spectrum disorder diagnosis in large cities in China.
‘It’s designed for someone who is not me’: A reflexive thematic analysis of the unmet healthcare support needs in UK autistic adults aged 65 years and over
Authors: Mansour Hassan , Gillions Amy , Brown Jude , Pattenden Anoushka , Hartley Susan , Patel Sarifa , James Stephanie , Styles Martin , Mandy Will , Stott Joshua , O’Nions Elizabeth 
Published: October 2024

Autistic people are more likely to experience physical and mental health difficulties across the lifespan, leading to an increased risk of premature mortality likely due to health disparities. At present, little is known about the healthcare experiences of autistic older adults. Semi-structured interviews were conducted with 19 autistic adults aged 65 years or over living in the United Kingdom. Reflexive thematic analysis produced these themes: (1) A lifetime of being misunderstood; (2) Autistic people falling between the gaps; (3) Processing autism diagnosis in later life; (4) Concerns about service pressures and scarce resources; (5) Lack of continuity of care, empathy and understanding; (6) Anxiety, alexithymia and sensory overload; and (7) Reduced social support and concerns for the future. Some of the challenges autistic older adults faced were like those experienced by younger or middle-aged autistic adults. However, they also reported additional difficulties related to ageing and lifelong experiences of social exclusion. These difficulties were made worse by increased service pressures. A comprehensive approach is needed, including enhanced staff training, personalised care, targeted support and policy changes. Services should also consult with autistic older adults so they can advocate for their care, shape policy and co-design services. Lay abstract Autistic people often face both physical and mental health challenges throughout their lives, which can lead to a higher risk of premature death due to health inequalities. However, we know very little about the healthcare experiences of autistic older adults. In this study, we talked with 19 autistic adults aged 65 years or above living in the United Kingdom. We found these main themes: (1) A lifetime of being misunderstood; (2) Autistic people falling between the gaps; (3) Processing autism diagnosis in later life; (4) Concerns about service pressures and scarce resources; (5) Lack of continuity of care, empathy and understanding; (6) Anxiety, alexithymia and sensory overload; and (7) Reduced social support and concerns for the future. Themes show that autistic older adults face unique healthcare access challenges because services don’t consider their lifelong experiences of social exclusion. Participants also worried about age-related decline coupled with reduced social support, which makes it harder for them to get support. To address these challenges, healthcare services should provide more targeted support, make policies and funding consistent, and improve healthcare provision by providing staff training. Importantly, they must also speak with autistic older adults so they can advocate for their current and future care.
COVID-19 and COVID-19 Vaccine-Related Skin Ulcerations in the Lower Extremities: A Case Report and Literature Review
Authors: Beaineh Paul , El-Bsat Ayman , Hafez Bassel , Bizri Abdul Rahman , Kibbi Abdul-Ghani , Merashli Mira , Haddad Fady 
Published: October 2024

Several associations have been made between COVID-19 and vasculitis. Recent data also shows the prevalence and association of de novo vasculitis with either COVID-19 infection or COVID-19 post vaccination. In this article, we present the case of new-onset leukocytoclastic vasculitis, secondary to COVID-19 vaccination, that was complicated by severe infected and nonhealing ulcers in the lower extremities. Case A 53-year-old male patient presented to the dermatology clinics with a three-week history of painful necrotic patches coalescent of the lateral malleolus of the right and left ankles. History goes back to when the patient reported developing pruritic papules two weeks after receiving his second shot of the Pfizer BioNTech COVID-19 vaccine (BNT162b2). Punch biopsy was consistent with leukocytoclastic vasculitis. He was prescribed a four-week course of systemic corticosteroids and antibiotics as per cultures. Vascular assessment confirmed normal peripheral arterial and venous system. Two months later, the patient re-presented with fever and worsening of his lower extremity ulcers. He underwent debridement of his wounds. Intra-operative cultures revealed multidrug resistant bacteria. He required an additional debridement session a few days later and a 14-day course of Piperacillin-Tazobactam. The patient was subsequently discharged on corticosteroids and Azathioprine and followed up in the vascular surgery and rheumatology clinics. At four months follow-up, the patient's wounds were almost completely healed. Conclusion This article highlights a case of severe new-onset COVID-19 vaccine-associated leukocytoclastic vasculitis complicated with infected ulcers that required debridement twice in addition to a prolonged course of antibiotics and immunosuppression therapy. To our knowledge, none of the cases reported in the literature were this severe in nature. In this post-pandemic era, it must remain high on the differential list, and healthcare specialists should maintain a high index of suspicion when evaluating sudden new-onset skin lesions that do not have an immediately apparent etiology.
Anatomy of Lister’s Tubercle: Implications for Volar Locked Plating of the Distal Radius
Authors: Laane Charlotte L.E. , Raasveld Floris V. , de Klerk Huub H. , Weigel Daniel T. , Pratap Jayanth S. , Chen Neal C. , Eberlin Kyle R. 
Published: October 2024

Background: Determining accurate intraoperative screw length in complex distal radius fractures may pose difficulties. With volar plate fixation, excessive screw length may result in extensor pollicis longus injury and this can be challenging to determine via intraoperative imaging. This study aims to identify the precise anatomic location and parameters of Lister’s tubercle on the dorsal aspect of the radius. Methods: The anatomy and location of Lister’s tubercle was evaluated in 26 cadaveric arms, of which 27% were female, with a mean age of 73.6 years. Additionally, Lister’s tubercle was evaluated on 198 computed tomography (CT) scans using a quantitative distal radius surface map. Median age was 28 years, and 28% of the patients were female. Results: As measured in cadaveric arms, the mean Lister’s tubercle length was 12.6 mm, and width was 5.4 mm. The distance from the radial styloid to the distal and proximal border of Lister’s tubercle averaged 23.0 and 10.4 mm, respectively. Of the total distal radial width, Lister’s tubercle begins 43% from the radial border and spans to 42% of the ulnar border, encompassing 16% of the entire width of the dorsal distal radius. On CT mapping, the distance between the peak of Lister’s tubercle and the ulnar and radial border of the radius was 46% and 54%, respectively. Female sex was associated with a smaller distal radius width, but not with a smaller Lister’s tubercle. Conclusions: Knowledge of Lister’s tubercle anatomy may assist in more precise screw placement in volar locked plating of distal radius fractures. Level of evidence: IV—Therapeutic.
Intraoperative Cost Comparison of Endoscopic Carpal Tunnel Release With WALANT Versus MAC Anesthesia
Authors: Godfrey Jenna M. , Benda John , Choi Won Jin , Tavakolian Jason D. , Owen Erin C. 
Published: October 2024

Background: The cost of endoscopic carpal tunnel release (ECTR) has historically been shown to be significantly higher than the cost of open carpal tunnel release (OCTR). Setting and anesthetic technique drive costs in hand surgery; ambulatory surgical center (ASC) settings demonstrate lower costs when compared to hospital-based settings and local-only anesthetic techniques demonstrate savings over general anesthesia. The purpose of this study is to compare wide awake local-only anesthesia technique (WALANT) to monitored anesthetic care (MAC) for ECTR performed in an ASC setting. Methods: This study includes 481 ECTR under WALANT and 405 ECTR under MAC, performed between January 2019 and December 2021 in an ASC. Utilizing previously reported direct operating room costs, overhead, and material costs, we calculated a final cost for each procedure. We also report our complication rates: intraoperative conversion to OCTR and late revision to OCTR. Results: Intraoperative times were shortest for ECTR performed under WALANT (22 min) versus ECTR under MAC (25 min). The total cost for ECTR under WALANT was most cost-effective at $1341.28 versus ECTR under MAC at $1634.00. Both techniques demonstrated a low complication profile. Conclusions: Our intraoperative process flow, staffing model, and ASC setting resulted in cost savings making ECTR an economically feasible option.