bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between operative technique and intrusive thoughts on health‐related Quality of Life 3 years after APE/ELAPE for rectal cancer: results from a national Swedish cohort with comparison with normative Swedish data
Authors: Prytz Mattias , Ledebo Anna , Angenete Eva , Bock David , Haglind Eva 
Published: April 2018

AbstractThe aim of this prospective registry‐based population study was to investigate the association between QoL 3 years after surgery for rectal cancer and intrusive thoughts and to assess the association with the type of surgery (i.e., APE or ELAPE) in a population‐based national cohort. ELAPE has been proposed as a superior surgical technique for distal rectal cancer, but long‐term effects on QoL are not known. There are also no studies on the association of negative intrusive thoughts on patients′ self‐reported Quality of Life following surgery for distal rectal cancer. Negative intrusive thoughts are regarded as a marker of incomplete cognitive processing of the psychological trauma caused by, for example, a cancer diagnosis. Intrusive thoughts have been recognized as an important factor associated Quality of Life outcome following surgery for other malignancies. All Swedish patients operated with any kind of abdominoperineal resection in the years 2007–2009 were identified through the Swedish ColoRectal Cancer Registry (SCRCR)—the APER population. All patients alive 3 years after surgery and willing to participate were included. Data were collected from three different sources: the registry, the original operative notes, and a study‐specific questionnaire regarding health‐related QoL answered by the patients. Questions on QoL from a normative reference population were also collected for comparison. Fifty‐six percent of the APER population reported a low overall Quality of Life. There was no significant difference between the sexes. Among men, there was a difference in overall QoL, with a higher level in the normative population (48%) compared with the male APER population (39%). Overall QoL was compared to a normative Swedish population. Almost half of the patients experienced negative intrusive thoughts, which was associated with a lower overall Quality of Life. The frequency and severity of negative intrusive thoughts were significantly associated with a low overall QoL. There was no difference in overall QoL after standard, compared with extralevator abdominoperineal excision. A large proportion of survivors after abdominoperineal excision for rectal cancer has a Quality of Life compared with a normative population, but many suffer from negative intrusive thoughts, a symptom of stress, which significantly decrease overall Quality of Life.
BCR‐ABL enhances the prolyl isomerase activity of Pin 1 by interacting with DAPK1 in ph+ALL
Authors: Cao Wen‐bin , Yao Jian‐feng , Feng Si‐zhou , He Yi , Jiang Er‐lie , Zhang Rong‐li , Yang Dong‐lin , Gong Ming , Zheng Xiao‐hui , Chen Shu‐lian , Sun Jia‐li , Zhou Lu‐kun , Han Ming‐zhe 
Published: April 2018

AbstractPhiladelphia chromosome (Ph)/BCR‐ABL‐positive (ph+) ALL is the most common genetic abnormality associated with ALL and has been shown to confer the worst prognosis to both children and adults. Increasing evidence has revealed that the dysregulation of prolyl isomerase Pin 1 contributes to multicancer development and progression, including ALL, although the underlying molecular mechanisms remain unclear. Here, we report that the expression of Pin 1 was enhanced in ph+ ALL patient samples and was associated positively with the expression of BCR‐ABL. Genetically or pharmacologically inhibiting Pin 1 expression or activity produces potent therapeutic efficacy against ph+ ALL. We further demonstrated that BCR‐ABL enhances the prolyl isomerase activity of Pin 1 by decreasing the phosphorylated level of Pin 1 at Ser 71 and interacting with DAPK1. The inhibition of BCR‐ABL activity by imatinib in human ph+ ALL cells reduces the prolyl isomerase activity of Pin 1, further suggesting a key role of the newly identified BCR‐ABL‐Pin 1 axis in ph+ ALL progression. Thus, the combined suppression of Pin 1 and BCR‐ABL proteins may be exploited as an additional target therapy for ph+ ALL.
Risk factors for length of stay and charge per day differ between older and younger hospitalized patients withAML
Authors: Kumar Anita J. , Henzer Tobi , Rodday Angie Mae , Parsons Susan K. 
Published: April 2018

AbstractAcute myeloid leukemia (AML) is associated with frequent hospitalizations. We evaluated factors associated with length of stay (LOS) and charge per day (CPD) for admissions in older (≥60 years) and younger patients (<60 years). We identified patients withICD‐9‐CMcodes forAMLor myeloid sarcoma in the 2012HCUP‐NIS. In separate models based on age, we examined patient (sex, race, income, insurance payer, chronic conditions, chemotherapy administration, death) and hospital (type, geography) characteristics. Multivariable negative binomial regression estimated factor effects onLOSandCPDusing rate ratios, withHCUP‐NISweights. In 43,820 discharges,LOSwas longer in patients <60 than ≥60 (6.8 vs. 5.4 days). For patients <60, longerLOSwas seen with more chronic conditions (RR = 1.10), Black race (RR = 1.16), chemotherapy (RR = 2.27), and geography; shorterLOSwas associated with older age (RR = 0.93), Medicare (RR = 0.83), and hospital type. For patients ≥60, longerLOSassociated with chronic conditions (RR = 1.07) and Asian race (RR = 1.33). ShorterLOSassociated with older age (RR = 0.86), higher income (RR = 0.93), and hospital type. For patients <60, higherCPDassociated with chronic conditions (RR = 1.05), death (RR = 1.93), and geography; lowerCPDassociated with increasing age (RR = 0.96), Medicaid (RR = 0.93), and rural hospitals (RR = 0.65). For patients ≥60, higherCPDassociated with Medicare (RR = 1.05), more chronic conditions (RR = 1.02), younger age (RR = 1.1), west geography (RR = 1.37), death (RR = 1.45), and Hispanic race (RR = 1.15). We identify predictors for increased healthcare utilization in hospitalized patients withAML, which differ within age groups. Future efforts are needed to link utilization outcomes with clinical treatments and response.
The influence of retailer size on consumer responses to social responsibility initiatives
Authors: Green Todd , Allen Alexis M. , Peloza John 
Published: April 2018

AbstractThe current research demonstrates that retailer size moderates the positive effect of corporate social responsibility (CSR) initiatives on consumer outcomes such as increased purchase intentions and perceptions of CSR. Retailer size is introduced as a factor that leads consumers to respond more positively to small retailers' CSR activities, relative to CSR from large retailers. We also provide support for the ability of consistency/commitment to CSR to serve as a means by which larger retailers can counter their size liability. We replicate and generalize these results across multiple CSR forms. Implications for retail management and future research are discussed.
Status of Demand‐Driven Biogas Concepts to Cover Residual Load Rises
Authors: Peters Lena , Uhlenhut Frank , Biernacki Piotr , Steinigeweg Sven 
Published: April 2018

AbstractFluctuations in wind and solar energy due to climatic conditions as well as the rising demand of renewable energy puts an increasingly stronger focus on alternative systems like the demand‐driven biogas production. Hence, currently examined concepts for flexibilization of biogas plants are described. The biogas storage as well as the demand‐driven biogas production by feeding management, variable conversion in electricity, disintegration processes, or packed‐bed fermentation belong to these concepts. Also, the combination with power‐to‐gas or power‐to‐heat systems seems promising and is discussed.
Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity
Authors: Nishio Kosuke , Belle Roman , Katoh Takayuki , Kawamura Akane , Sengoku Toru , Hanada Kazuharu , Ohsawa Noboru , Shirouzu Mikako , Yokoyama Shigeyuki , Suga Hiroaki 
Published: April 2018

AbstractThe ten–eleven translocation (TET) protein family, consisting of three isoforms (TET1/2/3), have been found in mammalian cells and have a crucial role in 5‐methylcytosine demethylation in genomic DNA through the catalysis of oxidation reactions assisted by 2‐oxoglutarate (2OG). DNA methylation/demethylation contributes to the regulation of gene expression at the transcriptional level, and recent studies have revealed that TET1 is highly elevated in malignant cells of various diseases and related to malignant alteration. TET1 inhibitors based on a scaffold of thioether macrocyclic peptides, which have been discovered by the random nonstandard peptide integrated discovery (RaPID) system, are reported. The affinity‐based selection was performed against the TET1 compact catalytic domain (TET1CCD) to yield thioether macrocyclic peptides. These peptides exhibited inhibitory activity of the TET1 catalytic domain (TET1CD), with an IC50 value as low as 1.1 μm. One of the peptides, TiP1, was also able to inhibit TET1CD over TET2CD with tenfold selectivity, although it was likely to target the 2OG binding site; this provides a good starting point to develop more selective inhibitors.
A Tryptophan Prenyltransferase with Broad Substrate Tolerance from Bacillus subtilis subsp. natto
Authors: Sugita Tomotoshi , Okada Masahiro , Nakashima Yu , Tian Tian , Abe Ikuro 
Published: April 2018

AbstractBacillus subtilis subsp. natto secretes the ComXnatto pheromone as a quorum‐sensing pheromone to produce poly‐γ‐glutamate for biofilm formation. The amino‐acid sequence of the pheromone is Lys‐Trp‐Pro‐Pro‐Ile‐Glu, and the tryptophan residue is post‐translationally modified with a farnesyl group to form a tricyclic scaffold. Unlike other Bacillus ComX pheromones, the tryptophan residue is distant from the C‐terminal end of the precursor peptide ComXnatto. Here, we report the functional analysis of ComQnatto, which catalyzes a unique farnesyl‐transfer reaction. ComQnatto recognizes not only full‐length ComXnatto but also N‐ and/or C‐terminal truncated ComXnatto analogues and even a single tryptophan for modification with a farnesyl group in vitro. These results, together with the calculated kinetic parameters, suggest that ComQnatto does not require a leader sequence for substrate recognition and is a promising enzyme with broad substrate tolerance for the synthesis of various prenylated tryptophan derivatives.
Listeria monocytogenes meningitis
Authors: Matsuo Takahiro , Mori Nobuyoshi , Sakurai Aki , Furukawa Keiichi 
Published: April 2018

Key Clinical MessageTumbling motility is one of the useful characteristics of Listeria monocytogenes. This can be helpful to identify the causative pathogen along with Gram staining before the confirmatory microbiological examination.
Single Metal Atoms Anchored in Two‐Dimensional Materials: Bifunctional Catalysts for Fuel Cell Applications
Authors: Back Seoin , Kulkarni Ambarish R. , Siahrostami Samira 
Published: April 2018

AbstractSingle metal atoms doped in two‐dimensional materials have attracted particular attention for various catalytic reactions, due to their unique properties beyond metal catalysts. Herein we present density functional theory (DFT) calculations to study a wide range of such systems for oxygen reduction reaction (ORR) and hydrogen oxidation reaction (HOR) for application in cathode and anode of fuel cell, respectively. We find that the scaling relation of adsorption free energies of relevant ORR intermediates changes in the direction of improved activity. By considering more than 50 combinations, various ORR and HOR candidates are identified with improved catalytic activities compared to the state‐of‐the‐art Pt (111). Particularly, Rh embedded in N‐doped graphene is predicted to be markedly active for bifunctional fuel cell catalysis. This work highlights the potential of these systems as new classes of electrocatalysts to maximize the ORR catalytic activity and alleviate the use of precious metals
Redox‐Responsive Covalent Organic Nanosheets from Viologens and Calix[4]arene for Iodine and Toxic Dye Capture
Authors: Skorjanc Tina , Shetty Dinesh , Sharma Sudhir Kumar , Raya Jesus , Traboulsi Hassan , Han Dong Suk , Lalla Jayesh , Newlon Ryan , Jagannathan Ramesh , Kirmizialtin Serdal , Olsen John‐Carl , Trabolsi Ali 
Published: April 2018

AbstractOwing to their chemical and thermal stabilities, high uptake capacities, and easy recyclability, covalent organic polymers (COPs) have shown promise as pollutant sponges. Herein, we describe the use of diazo coupling to synthesize two cationic COPs, COP1++ and COP2++, that incorporate a viologen‐based molecular switch and an organic macrocycle, calix[4]arene. The COPs form nanosheets that have height profiles of 6.00 nm and 8.00 nm, respectively, based on AFM measurements. The sheets remain morphologically intact upon one‐ or two‐electron reductions of their viologen subunits. MD simulations of the COPs containing dicationic viologens indicate that the calix[4]arenes adopt a partial cone conformation and that, in height, the individual 2D polymer layers are 5.48 Å in COP1++ and 5.65 Å in COP2++, which, together with the AFM measurements, suggests that the nanosheets are composed of 11 and 14 layers, respectively. Whether their viologens are in dicationic, radical cationic, or neutral form, the COPs exhibit high affinity for iodine, reaching up to 200 % mass increase when exposed to iodine vapor at 70 °C, which makes the materials among the best‐performing nanosheets for iodine capture reported in the literature. In addition, the COPs effectively remove Congo red from solution in the pH range of 2–10, reaching nearly 100 % removal within 15 minutes at acidic pH.
Detecting Proton Transfer in CO2 Species Chemisorbed on Amine‐Modified Mesoporous Silicas by Using 13C NMR Chemical Shift Anisotropy and Smart Control of Amine Surface Density
Authors: Čendak Tomaž , Sequeira Lisa , Sardo Mariana , Valente Anabela , Pinto Moisés L. , Mafra Luís 
Published: April 2018

AbstractThe wealth of site‐selective structural information on CO2 speciation, obtained by spectroscopic techniques, is often hampered by the lack of easy‐to‐control synthetic routes. Herein, an alternative experimental protocol that relies on the high sensitivity of 13C chemical shift anisotropy (CSA) tensors to proton transfer, is presented to unambiguously distinguish between ionic/charged and neutral CO2 species, formed upon adsorption of 13CO2 in amine‐modified porous materials. Control of the surface amine spacing was achieved through the use of amine protecting groups during functionalisation prior to CO2 adsorption. This approach enabled the formation of either “isolated” or “paired” carbamate/carbamic acid species, providing a first experimental NMR proof towards the identification of both aggregation states. Computer modelling of surface CO2‐amine adducts assisted the solid‐state NMR assignments and validated various hydrogen‐bond arrangements occurring upon formation of isolated/aggregated carbamic acid and alkylammonium carbamate ion species. This work extends the understanding of chemisorbed CO2 structures formed at pore surfaces and reveals structural insight about the protonation source responsible for the proton‐transfer mechanism in such aggregates.
Synthesis of 3H‐Benzo[e]indoline and Its Application to Small‐Molecule Organic Solar Cells
Authors: Chen Yao , Wu Jianglin , Yang Lin , Hu Bin , Yang Daobin , Lu Zhiyun , Huang Yan 
Published: April 2018

AbstractA squaraine‐based small molecule (USQ‐BI) bearing 3H‐benzo[e]indoline was synthesized as an electron donor, and the corresponding organic solar cells show power conversion efficiency of 5.35 % with an excellent short circuit current of over 15 mA cm−2. The hole mobility of USQ‐BI was about 5 times (9.57×10−5 vs. 2.00×10−5 cm2 V−1 s−1) higher than that of indoline‐based squaraine.
Luminescent‐Substituted Fluoranthenes—Synthesis, Structure, Electrochemistry, and Optical Properties
Authors: Slodek Aneta , Maroń Anna , Pająk Michał , Matussek Marek , Grudzka‐Flak Iwona , Małecki Jan G. , Świtlicka Anna , Krompiec Stanisław , Danikiewicz Witold , Grela Małgorzata , Gryca Izabela , Penkala Mateusz 
Published: April 2018

AbstractSix novel fluoranthene derivatives, namely, three terminally substituted and three bis(fluoranthene) units with fluorene, bithiophene, and carbazole spacers, were obtained through [2+2+2] cycloaddition and characterized completely. Based on the conducted studies, the obtained derivatives can be classified as donor–acceptor (D‐A) and acceptor‐donor‐acceptor (A‐D‐A) systems, in which the fluoranthene unit acts as an electron‐withdrawing unit. The optical results revealed that novel fluoranthene derivatives absorb light in the range λ=236–417 nm, which originates from a π→π* transition within the conjugated system. The compounds exhibit fluorescence that range from deep blue to green, which mainly arises from intramolecular charge transfer (ICT) states. High Stoke shifts and high quantum yields in solution (ϕ=0.22–0.57) and in the solid state (ϕ=0.18–0.44) have been observed for fluoranthene derivatives. All the derivatives display multistep oxidation processes at low potentials. The electronic structure of the presented compounds is additionally supported by time‐dependent DFT computations.
A General Pathway for the Synthesis of Gallastibenes containing Ga=Sb Double Bonds
Authors: Krüger Julia , Ganesamoorthy Chelladurai , John Lukas , Wölper Christoph , Schulz Stephan 
Published: April 2018

AbstractReactions of three equivalents of LGa {L=HC[C(Me)N(2,6‐iPr2C6H3)]2} with SbX3 (X=F, Cl, Br, I) proceed with insertion into the Sb−X bond, elimination of LGaX2, and formation of LGaSbGa(X)L (X=F 1, Cl 2, Br 3, I 4) containing a Ga=Sb double bond. In contrast, the 2:1 molar ratio reaction of LGa and SbCl3 initially gives the twofold insertion product [L(Cl)Ga]2SbCl 7, which could not be isolated due to its strong tendency toward elimination of LGaCl2 and formation of distibene [L(Cl)GaSb]2 5 at 25 °C or cyclotristibine [L(Cl)GaSb]3 6 at 8 °C. The formation of 1–6 can be rationalized by formation of the Ga‐substituted stibinidene L(X)GaSb as reaction intermediate.
Photochemical and Electrochemical Carbon Dioxide Utilization with Organic Compounds
Authors: Cao Yu , He Xing , Wang Ning , Li Hong‐Ru , He Liang‐Nian 
Published: April 2018

AbstractIn the last few years, photochemical and electrochemical CO2 transformations have attracted increasing attention in response to topical interest in renewable energy and green chemistry. The present minireview offers an overview about the current approaches for the photochemical and electrochemical carbon dioxide fixation with organic compounds. Valuable products, including carboxylic acids and heterocyclic compounds, are accessible through carboxylation and carboxylative cyclization, respectively. In photochemical and electrochemical processes, photo‐ or electro‐induced radical ions or other high‐energy organic compounds are considered as key intermediates to react with CO2. Besides, activation of CO2 to produce radical anion has also been reported.
Back Cover: Lactonization of C(sp2)—H Bonds in Enamides with CO2 (Chin. J. Chem. 5/2018)
Authors: Zhang Zhen , Zhu Chun‐Jun , Miao Meng , Han Jie‐Lian , Ju Tao , Song Lei , Ye Jian‐Heng , Li Jing , Yu Da‐Gang 
Published: April 2018

The back cover picture shows a novel synthesis of 1,3‐oxazin‐6‐ones from enamides with CO2 through C—H carboxylation and one‐pot cyclization. The concept of “CO2 = CO + O”, using CO2 to replace toxic CO and stoichiometric oxidant, guilds the development of this chemistry as well as green and safe synthetic methods in the future. More details are discussed in the article by Yu et al. on page 430–436.
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Time trends in antithrombotic management of patients with atrial fibrillation treated with coronary stents: Results from TALENT‐AF (The internAtionaL stENT – Atrial Fibrillation study) multicenter registry
Authors: Potter Brian J. , Andò Giuseppe , Cimmino Giovanni , Ladeiras‐Lopes Ricardo , Frikah Zied , Chen Xin Yue , Virga Vittorio , Goncalves‐Almeida Joao , Camm A. John , Fox Keith A.A. 
Published: April 2018

BackgroundAntithrombotic management of patients with atrial fibrillation (AF) requiring percutaneous coronary intervention (PCI) is highly variable; limited evidence‐based guidelines exist to influence practice.HypothesisPatient characteristics and availability of novel drugs may have contributed to practice variability.MethodsWe undertook an international multicenter retrospective registry of AF patients treated with PCI. The primary measures of interest were antiplatelet and OAC prescriptions at discharge. We compared temporal trends between Prior (2010–2012) and Recent (2013–2015) cohorts and investigated variables associated with OAC prescription.ResultsWe identified 488 cases (140 Prior, 348 Recent). Median CHADS2 and HAS‐BLED scores were 2 (IQR, 1–3) and 2 (IQR, 2–3). Clinical characteristics were similar between cohorts, with high (85%) prevalence of ACS. More patients in the Recent cohort, compared with Prior, received OAC (56.9% vs 44.3%; P = 0.01) and NOAC (27.3% vs 3.6%; P < 0.01) at baseline. Triple therapy at discharge was not different between the cohorts. Clinical presentation with ACS and consequent use of potent P2Y12 inhibitors were associated with reduced odds of OAC prescription at discharge (OR: 0.57, P = 0.045 and OR: 0.38, P = 0.023, respectively).ConclusionsDespite little change over time in clinical characteristics of AF patients undergoing PCI, significantly more patients received OAC at presentation. However, triple therapy was not more frequent in the Recent cohort, and ACS presentation was associated with lack of OAC at discharge. We underscore the need for trial evidence and use of updated guidelines to assist clinicians in balancing ischemic and bleeding risks.
Complexity of scar and ventricular arrhythmias in dilated cardiomyopathy of any etiology: Long‐term data from the SCARFEAR (Cardiovascular Magnetic Resonance Predictors of Appropriate Implantable Cardioverter‐Defibrillator Therapy Delivery) Registry
Authors: Pedretti Stefano , Vargiu Sara , Baroni Matteo , Dellegrottaglie Santo , Lanzarin Barbara , Roghi Alberto , Milazzo Angela , Quattrocchi Giuseppina , Lunati Maurizio , Pedrotti Patrizia 
Published: April 2018

BackgroundLate gadolinium enhancement (LGE) assessed with cardiovascular magnetic resonance (CMR) correlates with ventricular arrhythmias and survival in patients with structural heart disease. Whether some LGE characteristics may specifically improve prediction of arrhythmic outcomes is unknown.HypothesisWe sought to evaluate scar characteristics assessed with CMR to predict implantable cardioverter‐defibrillator (ICD) interventions in dilated cardiomyopathy of different etiology.Methods96 consecutive patients evaluated with CMR received an ICD. Biventricular volumes, ejection fraction, and myocardial LGE were evaluated. LGE was defined as “complex” (Cx‐LGE) in presence of ≥1 of the following: ischemic pattern, involving ≥2 different coronary territories; epicardial pattern; global endocardial pattern; and presence of ≥2 different patterns. The primary endpoint was occurrence of any appropriate ICD intervention. A composite secondary endpoint of cardiovascular death, cardiac transplantation, or ventricular assist device implantation was also considered.ResultsDuring a median follow‐up of 75 months, 30 and 25 patients reached the primary and secondary endpoints, respectively. Cx‐LGE was correlated with a worse primary endpoint survival (log‐rank P < 0.001). Cx‐LGE and right ventricular end‐diastolic volume were independently associated with the primary endpoint (HR: 3.22, 95% CI: 1.56–6.65, P = 0.002; and HR: 1.06, 95% CI: 1.00–1.12, P = 0.045, respectively), but not with the secondary endpoint.ConclusionsCx‐LGE identified at CMR imaging seems promising as an independent and specific prognostic factor of ventricular arrhythmias requiring ICD therapy in dilated cardiomyopathy of different etiologies.