bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human antibody responses against non-covalently cell wall-bound Staphylococcus aureus proteins
Authors: Romero Pastrana Francisco , Neef Jolanda , Koedijk Dennis G. A. M. , de Graaf Douwe , Duipmans José , Jonkman Marcel F. , Engelmann Susanne , van Dijl Jan Maarten , Buist Girbe 
Published: February 2018

AbstractHuman antibody responses to pathogens, likeStaphylococcus aureus, are important indicators forin vivoexpression and immunogenicity of particular bacterial components. Accordingly, comparing the antibody responses toS. aureuscomponents may serve to predict their potential applicability as antigens for vaccination. The present study was aimed at assessing immunoglobulin G (IgG) responses elicited by non-covalently cell surface-bound proteins ofS. aureus, which thus far received relatively little attention. To this end, we applied plasma samples from patients with the genetic blistering disease epidermolysis bullosa (EB) and healthyS. aureuscarriers. Of note, wounds of EB patients are highly colonized withS. aureusand accordingly these patients are more seriously exposed to staphylococcal antigens than healthy individuals. Ten non-covalently cell surface-bound proteins ofS. aureus, namely Atl, Eap, Efb, EMP, IsaA, LukG, LukH, SA0710, Sle1 and SsaA2, were selected by bioinformatics and biochemical approaches. These antigens were recombinantly expressed, purified and tested for specific IgG responses using human plasma. We show that high exposure of EB patients toS. aureusis mirrored by elevated IgG levels against all tested non-covalently cell wall-bound staphylococcal antigens. This implies that theseS. aureuscell surface proteins are prime targets for the human immune system.
Dynamic contrast-enhanced magnetic resonance imaging for head and neck cancers
Authors:   Joint Head and Neck Radiotherapy-MRI Development Cooperative, Elhalawani Hesham , Ger Rachel B. , Mohamed Abdallah S. R. , Awan Musaddiq J. , Ding Yao , Li Kimberly , Fave Xenia J. , Beers Andrew L. , Driscoll Brandon , Hormuth II David A. , van Houdt Petra J. , He Renjie , Zhou Shouhao , Mathieu Kelsey B. , Li Heng , Coolens Catherine , Chung Caroline , Bankson James A. , Huang Wei , Wang Jihong , Sandulache Vlad C. , Lai Stephen Y. , Howell Rebecca M. , Stafford R Jason , Yankeelov Thomas E. , van der Heide Uulke A. , Frank Steven J. , Barboriak Daniel P. , Hazle John D. , Court Laurence E. , Kalpathy-Cramer Jayashree , Fuller Clifton D. 
Published: February 2018

AbstractDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been correlated with prognosis in head and neck squamous cell carcinoma as well as with changes in normal tissues. These studies implement different software, either commercial or in-house, and different scan protocols. Thus, the generalizability of the results is not confirmed. To assist in the standardization of quantitative metrics to confirm the generalizability of these previous studies, this data descriptor delineates in detail the DCE-MRI digital imaging and communications in medicine (DICOM) files with DICOM radiation therapy (RT) structure sets and digital reference objects (DROs), as well as, relevant clinical data that encompass a data set that can be used by all software for comparing quantitative metrics. Variable flip angle (VFA) with six flip angles and DCE-MRI scans with a temporal resolution of 5.5 s were acquired in the axial direction on a 3T MR scanner with a field of view of 25.6 cm, slice thickness of 4 mm, and 256×256 matrix size.
Simulations in the Analysis of Experimental Data Measured by BM@N Drift Chambers
Authors: Fedorišin Ján 
Published: February 2018

The drift chambers (DCH’s) are an important part of the tracking system of the BM@N experiment designed to study the production of baryonic matter at the Nuclotron energies.
The method of particle hit and track reconstruction in the drift chambers has been already proposed and tested on the BM@N deuteron beam data. In this study the DCH’s are first locally and globally aligned, and subsequently the consistency of the track reconstruction chain is tested by two methods. The first one is based on the backward extrapolation of the DCH reconstructed deuteron beam to a position where its deflection in the BM@N magnetic field begins. The second method reconstructs the deuteron beam momentum through its deflection angle. Both methods confirm correctness of the track reconstruction algorithm.
Strange Particle Reconstruction by the Missing Mass Method
Authors: Kisel Pavel , Kisel Ivan , Senger Peter , Vassiliev Iouri , Zyzak Maksym 
Published: February 2018

The main goal of modern heavy-ion experiments is a comprehensive study of the QCD phase diagram, in a region of Quark-Gluon Plasma (QGP) and possible phase transition to QGP phase.
Strange particles produced in the collision are sensitive probes of the created media. Reconstruction of Σ particles together with other strange particles completes the picture of strangeness production. Σ+ and Σ− have all decay modes with at least one neutral daughter, which can not be registered by the CBM detector.
For their identification the missing mass method is proposed: a) tracks of the mother (Σ−) and the charged daughter (π−) particles are reconstructed in the tracking system; b) the neutral daughter particle (n) is reconstructed from these tracks; c) a mass constraint is set on the reconstructed neutral daughter; d) the mother particle is constructed of the charged and reconstructed neutral daughter particles and the mass spectrum is obtained, by which the particle can be identified.
The method can be applied for other strange particles too. In total 18 particle decays with neutral daughter are now included into physics analysis.
Arthroscopic Treatment of Symptomatic Congenital Lunotriquetral Coalition
Authors: Mariotte Benoit , Candelier Gilles , Apard Thomas 
Published: February 2018

AbstractSymptomatic lunotriquetral coalition is very rare and need open surgery after failure of conservative treatment. We report a case of a symptomatic congenital lunotriquetral coalition type 1 according to the Minaar classification, at the left wrist of a 14-year-old boy. We performed an arthroscopic treatment with two compression screws and without cancellous bone grafting. Healing was obtained at 2 months postoperatively.
Immunsuppressiva-Adhärenz nach Transplantation
Authors: Nöhre Mariel , Erim Yesim , Vitinius Frank , Klewitz Felix , Schiffer Mario , de Zwaan Martina 
Published: February 2018

ZusammenfassungDie Transplantation stellt für viele Patienten mit chronischem Organversagen die bestmögliche und teilweise einzige Therapieoption dar. Häufig erleben die Patienten nach erfolgreicher Transplantation eine deutliche Verbesserung ihres Zustandes, allerdings sind sie nicht geheilt sondern noch immer chronisch krank. Das Leben mit dem transplantierten Organ erfordert die konsequente Einnahme immunsuppressiver Medikation, regelmäßige Arztbesuche und die Befolgung von Empfehlungen zur Infektionsvermeidung. Diese Faktoren sind wichtig für ein langes Transplantatüberleben. Besonders die Non-Adhärenz zur immunsuppressiven Medikation ist ein Risikofaktor für Abstoßung des Transplantats. Die Gründe für non-adhärente Verhaltensweisen sind vielfältig. Allerdings ist es von großer Bedeutung die individuellen Gründe genau zu identifizieren, um ihnen angemessen begegnen zu können. Ziel dieses Artikels ist es, einen Überblick über Adhärenz beeinflussende Faktoren zu geben, Möglichkeiten zur Adhärenzerfassung vorzustellen, sowie verschiedene Ansätze zu präsentieren, um die Adhärenz zu verbessern. Randomisiert-kontrollierte Interventionsstudien werden vorgestellt und davon ausgehend Empfehlungen für die Praxis abgeleitet.
Restriktive versus liberale Transfusionspraxis
Authors: Sartorius Jürgen 
Published: February 2018

ZusammenfassungDie Risiken im Zusammenhang mit der Transfusionen von Fremdblut geraten immer wieder in die Diskussion.
Infektionsrisiken durch Kontamination sind in Deutschland zwar inzwischen nahezu ausgeschlossen, jedoch wurden
in der Vergangenheit immer wieder transfusionsbedingte Komplikationen durch Immunmodulationen beobachtet. Dazu
kommt, dass inzwischen viele Analysen zeigen, dass die positiven Auswirkungen der Transfusion auf die
Patienten statistisch nicht zunehmen, wenn die Zahl der Transfusionen steigt. Deshalb fordern verschiedene
Leitlinien und das „Patient Blood Management“: So viele Transfusionen wie nötig, aber so wenig wie möglich.
Dazu geben sie konkrete Empfehlungen zu einer „restriktiven“ Transfusionsroutine, insbesondere in
Operationssälen und Intensivstationen.
Multimodales Patient Blood Management
Authors: Wolf Katrin 
Published: February 2018

ZusammenfassungIn unserer zunehmend älter werdenden Gesellschaft nimmt die Zahl an Operationen und Interventionen derzeit
kontinuierlich zu. Damit erhöht sich auch das Risiko für einen perioperativen Blutverlust mit irreversiblem
Erythrozytenverlust und damit notwendigen Bluttransfusionen. Die WHO empfiehlt bereits seit 2010 entsprechende
Gegenmaßnahmen durch entsprechendes umfassendes Patient Blood Management (PBM) zu implementieren. Die
rechtzeitige Anwendung eines multimodalen interdisziplinären Konzepts kann patienteneigene Blutressourcen so
weit wie möglich schonen und damit die Behandlungsqualität und die Patientensicherheit verbessern.
Mittlerweile belegen mehrere Studien die Sicherheit und Wirksamkeit des PBM. Die Transfusionsrate kann
deutlich gesenkt werden und das bedeutet für den Patienten einen signifikant besseres Behandlungsergebnis bei
kürzeren Krankhausaufenthalten. Gleichzeitig ist dies mit massiven Einsparungen verbunden, auch wenn die
Implementierung des PBM sowie die Kosten für Projektmanagement, Diagnostik und Therapie der Anämie
mitberücksichtigt werden müssen.
Klinische Erkenntnisse zu moderner i.v.-Eisentherapie
Authors: Salama-Müller Andera , Reuther Susanne , Meybohm Patrick , Wiedemann Günther J. , Leschke Matthias 
Published: February 2018

ZusammenfassungDie Erfahrungen zur modernen i. v.-Eisentherapie aus den letzten 10 Jahren zeigen deutlich, dass im Rahmen der
Diagnostik und Therapie des Eisenmangels und der Eisenmangel-Anämie insbesondere bei Bestehen von chronischen
Grunderkrankungen, eine Neubewertung verschiedener Parameter sowie Hypothesen notwendig ist. Des Weiteren
zeigen zahlreiche klinische Ergebnisse, dass Eisenmangel von der Eisenmangelanämie als eigene Entität deutlich
abzugrenzen ist, da durch den alleinigen Eisenmangel ein erheblich schlechterer klinischer Verlauf sowie eine
erhöhte Rehospitalisierungs-, Morbiditäts- und Mortalitätsrate zu beobachten ist.
The representations of racism in immigrant students’ essays in Greece
Authors: Archakis Argiris 
Published: February 2018

Abstract
Racism as a means for accomplishing homogeneity is at the center of this study which draws on Critical Discourse Analysis and focuses on descriptions of racist behaviors included in immigrant students’ school essays. We investigate how the dominant assimilative and homogenizing discourse operates in Greece and how immigrant students position themselves towards this dominant discourse. Our analysis focuses on the ways the immigrant students of our sample construct legitimizing and hybrid resistance identities. We demonstrate that legitimizing identities are found in the vast majority of the essays of our data due to the racist behaviors experienced by immigrant people. On the other hand, the explicit description of such behaviors appears only in few essays. We argue that in these few essays, via referring to racist behaviors of majority people against them, immigrant students manage to build hybrid resistance identities.
On period relations for automorphic 𝐿-functions I
Authors: Januszewski Fabian 
Published: February 2018

This paper is the first in a series of two dedicated to the study of period relations of the type

L

(

1
2

+
k
,
Π

)

∈

(
2
π
i

)

d
⋅
k

Ω

(
−
1

)
k

\bf Q

(
Π
)
,

1
2

+
k

critical
,

\begin{equation*} L\Big (\frac {1}{2}+k,\Pi \Big )\;\in \;(2\pi i)^{d\cdot k}\Omega _{(-1)^k}\textrm {\bf Q}(\Pi ),\quad \frac {1}{2}+k\;\text {critical}, \end{equation*}

for certain automorphic representations

Π
\Pi

of a reductive group

G
.

G.

In this paper we discuss the case

G
=

G
L

(
n
+
1
)
×

G
L

(
n
)
.

G=\mathrm {GL}(n+1)\times \mathrm {GL}(n).

The case

G
=

G
L

(
2
n
)

G=\mathrm {GL}(2n)

is discussed in part two. Our method is representation theoretic and relies on the author’s recent results on global rational structures on automorphic representations. We show that the above period relations are intimately related to the field of definition of the global representation

Π
\Pi

under consideration. The new period relations we prove are in accordance with Deligne’s Conjecture on special values of

L
L

-functions, and the author expects this method to apply to other cases as well.
Regional-scale surface temperature variability allows prediction of Pacific bluefin tuna recruitment
Authors: Muhling Barbara A , Tommasi Desiree , Ohshimo Seiji , Alexander Michael A , DiNardo Gerard 
Published: February 2018

AbstractFuture sustainable management of fisheries will require resilience to the effects of environmental variability and climate change on stock productivity. In this study, we examined relationships between sea surface temperature (SST) in the region between Taiwan and the Sea of Japan, and annual recruitment of Pacific bluefin tuna (Thunnus orientalis: PBF) over the past 35 years. Spatial correlation maps showed that warmer SSTs south of Shikoku, in the East China Sea and in the Sea of Japan from summer to late fall were associated with above average recruitment. SST anomalies near larval and juvenile habitats were most strongly correlated with local air temperatures. Generalized Additive Models predicting annual PBF recruitment from SST fields suggested that the influence of SST on recruitment was stronger than that of spawning stock biomass. Correlations between SST and recruitment likely reflect biological processes relevant to early juvenile habitat suitability. The influence of late fall SSTs could also be a result of varying availability of age-0 fish to the troll fishery; however, the relative importance of these processes was not clear. Despite these knowledge gaps, the strong predictive power of SST on PBF recruitment can allow more proactive management of this species under varying environmental conditions.
Cost-effectiveness of hydrotherapy versus land-based therapy in patients with musculoskeletal disorders in Singapore
Authors: Teng Monica , Zhou Hui Jun , Lin Liang , Lim Pang Hung , Yeo Doreen , Goh Suzanne , Tjan Soon Yin , Lim Boon Peng 
Published: February 2018

AbstractBackgroundThe study evaluated the cost-effectiveness of hydrotherapy versus land-based therapy in patients with musculoskeletal disorders (MSDs) in Singapore.MethodsA decision-analytic model was constructed to compare the cost-effectiveness of hydrotherapy to land-based therapy over 3 months from societal perspective. Target population comprised patients with low back pain (LBP), osteoarthritis (OA), rheumatoid arthritis (RA), total hip replacement (THR) and total knee replacement (TKR). Subgroup analyses were carried out to determine the cost-effectiveness of hydrotherapy in individual MSDs. Relative treatment effects were obtained through a systematic review of published data.ResultsCompared to land-based therapy, hydrotherapy was associated with an incremental cost-effectiveness ratio (ICER) of SGD 27 471 per quality-adjusted life-year (QALY) gained, which was below the willingness-to-pay threshold of SGD 70 000 per QALY (one gross domestic product per capita in Singapore in 2015). For the respective MSDs, hydrotherapy were dominant (more effective and less costly) in THR and TKR, cost-effective for LBP and RA, and not cost-effective for OA. Treatment adherence and cost of hydrotherapy were key drivers to the ICER values.ConclusionsHydrotherapy was a cost-effective rehabilitation compared to land-based therapy for a population with MSDs in Singapore. However, the benefit of hydrotherapy was not observed in patients with OA.
Rutaecarpine Suppresses Proliferation and Promotes Apoptosis of Human Pulmonary Artery Smooth Muscle Cells in Hypoxia Possibly Through HIF-1α–Dependent Pathways
Authors: Deng Jun , Qin Jiajia , Cai Yi , Zhong Xiaobin , Zhang Xu , Yu Shanshan 
Published: February 2018

Purpose:
The aim of this study is to investigate the potential roles of Rutaecarpine (Rut) in hypoxia-induced human pulmonary artery smooth muscle cells (HPASMCs) model.

Methods:
HPASMCs were cultured with or without hypoxia followed by Rut administration. Cytotoxicity and cell proliferation were assessed by CCK-8 and Cell counting method. Flow cytometry was used for the measurement of cell apoptosis rates. The mRNA expression of hypoxia-induced factor (HIF)-1α and protein levels of HIF-1α, p53, p21, erythropoietin, and vascular endothelial growth factor were determined by quantitative real-time polymerase chain reaction and Western blot, respectively.

Results:
Rut inhibited the proliferation of HPASMCs with IC50 value of 43.5 μmol·L−1. Hypoxia significantly increased proliferation and decreased apoptosis in HPASMCs, whereas Rut rescued this phenomenon at the appropriate concentration. Meanwhile, Rut effectively decreased the protein and mRNA expressions of HIF-1α. Knockdown of HIF-1α expression by small interfering RNA (siRNA) significantly enhanced the proapoptotic effect rather than antiproliferation effect of Rut in HPASMCs. Moreover, Rut simultaneously reduced proliferating cell nuclear antigen protein expression, whereas increased p53 and p21 protein levels. However, no significant difference was observed in the protein levels of vascular endothelial growth factor and erythropoietin.

Conclusions:
Our results demonstrated that Rut exerted protective effects on HPASMCs against hypoxia partly through the HIF-1α–dependent signaling pathway.
The effects of stair climbing on arterial stiffness, blood pressure, and leg strength in postmenopausal women with stage 2 hypertension
Authors: Wong Alexei , Figueroa Arturo , Son Won-Mok , Chernykh Oksana , Park Song-Young 
Published: February 2018

Abstract

Objective:
Menopause is accompanied by a progressive arterial stiffening associated with increases in blood pressure (BP) and decline in muscular function. It is crucial to prevent or reduce the negative effects of menopause on vascular and muscular function by implementing appropriate lifestyle interventions, such as exercise training. We examined the effects of a stair climbing (SC) regimen on arterial stiffness (pulse wave velocity [PWV]), BP, and leg strength in postmenopausal women with stage 2 hypertension.

Methods:
Using a parallel experimental design, participants were randomly assigned to either SC (n = 21) or nonexercising control group (n = 20) for 12 weeks. Participants in the SC group trained 4 d/wk, climbing 192 steps 2 to 5 times/d. Participants’ brachial-to-ankle PWV (baPWV), BP, and leg strength were measured at baseline and after 12 weeks of their assigned intervention.

Results:
There was a significant group by time interaction (P < 0.05) for baPWV, and systolic BP (SBP) and diastolic BP (DBP) which significantly decreased (P < 0.05), and leg strength which significantly increased (P < 0.05) after SC compared with no changes in the control. The changes in baPWV were correlated with changes in SBP (r = 0.66, P < 0.05) and leg strength (r = −0.47, P < 0.05).

Conclusions:
SC led to reductions in arterial stiffness, BP, and increases in leg strength in stage 2 hypertensive postmenopausal women. The decrease in arterial stiffness partially explained the improvements in SBP and leg strength. SC may be an effective intervention in the prevention and treatment of menopause/aging-related vascular complications and muscle weakness.
Plasma Concentration of Biomarkers Reflecting Endothelial Cell- and Glycocalyx Damage are Increased in Patients With Suspected ST-Elevation Myocardial Infarction Complicated by Cardiogenic Shock
Authors: Frydland Martin , Ostrowski Sisse Rye , Møller Jacob Eifer , Hadziselimovic Edina , Holmvang Lene , Ravn Hanne Berg , Jensen Lisette Okkels , Pettersson Anna Sina , Kjaergaard Jesper , Lindholm Matias Greve , Johansson Pär Ingemar , Hassager Christian 
Published: February 2018

ABSTRACT

Background:
Mortality in ST-elevation myocardial infarction (STEMI) patients developing cardiogenic shock (CS) during hospitalization is high. Catecholamines, ischemia, and inflammation (parameters present in CS) affect the endothelium. We hypothesized that plasma level of biomarkers reflecting endothelial damage would be associated with CS and mortality.

Methods:
In 96% of 1467 consecutive patients with suspected STEMI, biomarkers reflecting endothelial cell- (soluble thrombomodulin, sTM) and glycocalyx- (syndecan-1) damage were measured on admission. Patients were stratified by CS development or not. CS-Patients were substratified by CS on admission (admission-CS), CS developed in the catheterization laboratory (cath. lab.-CS), or late CS.

Results:
STEMI patients with admission-CS (n = 85) and cath.lab.-CS (n = 25) had higher levels of sTM and syndecan-1 compared with no-CS patients (n = 1,299). Late CS-patients (n = 58) had higher levels of sTM (median (25th; 75th percentile) 8.8 (7.0; 11.6) vs. 7.4 (6.0; 9.0) ng/mL, P = 0.0004) but not Syndecan-1 (P = 0.26) compared with no-CS patients. sTM was, however, not independently associated with late CS development (OR (95% CI) 1.07 (0.99–1.16), P = 0.09). Patients with the highest level of sTM and syndecan-1 had the highest 30-day mortality (P
logrank<0.0001). However, neither sTM nor Syndecan-1 was independently associated with 30-day mortality (HR (95% CI) sTM: 1.06 (0.996–1.12), P = 0.07; Syndecan-1: 1.04 (0.99–1.08), P = 0.12).

Conclusion:
Patients with suspected STEMI patients and admission-CS/cath.lab.-CS had elevated admission levels of sTM and Syndecan-1 compared with no CS patients. Patients developing late CS had higher sTM plasma concentration compared with patients without shock. However, the biomarker levels were not independently associated with late CS and mortality.