bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarker Discovery from We to Me: Is Learning from Each Patient a New Approach?
Authors: Lheureux Stephanie 
Published: March 2018

Abstract
The immune response is a dynamic multistep process with a complex system regulation. Identification of predictive biomarkers is therefore challenging. Deep investigation of an exceptional responder to pembrolizumab in ovarian cancer identifies a new mechanism of response and highlights the interest of individualized medicine strategy. Clin Cancer Res; 24(14); 3233–5. ©2018 AACR.
See related article by Bellone et al., p. 3282
Direito das águas - trajetória legal, conflitos e participação social
Authors: Rocha Julio Cesar de Sá da , Khoury Luciana Espinheira da Costa , Damasceno Ângela Patrícia Deiró 
Published: March 2018

O presente artigo faz uma breve análise da gestão brasileira de recursos hídricos a partir da política nacional de gestão das águas, transitando por aspectos referentes à previsão normativa, à implementação dos instrumentos de gestão, a alguns dos principais conflitos e à participação social realizada por meio de comitês de bacia hidrográfica, que são os parlamentos das águas, conforme indicado no arcabouço legal. Para tanto, foi realizada uma revisão bibliográfica que inclui autores clássicos e contemporâneos, leis e resoluções, bem como atas de reuniões de organismos de bacia hidrográfica. Os resultados obtidos destacam que a gestão compartilhada das águas, conforme preconizado no marco legal, ainda precisa superar obstáculos de diferentes naturezas para que, de fato, seja efetivada, visto que a equação entre descentralização do poder e participação social ainda demanda ajustes para um equilíbrio de forças.
O programa de controle de infecção relacionada à assistência à saúde em meio ambiente hospitalar e o dever de fiscalização da Agência Nacional de Vigilância Sanitária
Authors: Gomes Magno Federici , Moraes Vivian Lacerda 
Published: March 2018

O presente artigo estuda a função de fiscalização da Agência Nacional de Vigilância Sanitária nos casos de infecção hospitalar e, em especial, no que tange ao programa de Controle deInfecção relacionada à assistência à saúde, utilizado pelos estabelecimentos de saúde para minimizar os riscos de infecção por patógenos. Trata-se de artigo teórico-documental, com a análise da legislação pertinente e os riscos existentes para pacientes e profissionais da saúde no ambiente hospitalar. O estudo traz como proposta uma reflexão sobre a necessidade de fiscalização efetiva por parte da agência nos estabelecimentos de saúde e esboça formas de buscar a efetivação do poder de polícia.
A mediação como meio de resolução de conflitos na área de saúde
Authors: Ribeiro Wesllay Carlos 
Published: March 2018

O estudo aborda a utilização institucional da mediação na área de saúde. A mediação tem sido utilizada em vários países e se apresentado como uma tendência mundial em diferentes temas, entre eles o acesso à saúde. No Brasil, se têm notícias de algumas iniciativas com a finalidade de utilizar a mediação como meio de resolução de controvérsias na área de saúde, todavia é necessário cuidado e debate sobre essas técnicas a fim de que não se tornem meios de aumento da desigualdade social.
<b><I>Pternopetalum latipinnulatum</I> (Apiaceae), a new record for the flora of India</b>
Authors: Jeri Licha , Bhat Nazir Ahmad , Kumar Yogendra 
Published: March 2018

Pternopetalum latipinnulatum (Shan) J.B. Tan & X.J. He, previously known as an endemic species of China is now reported for the first time from Arunachal Pradesh. Detailed information about its description along with photographic illustration and a species key to related species of Pternopetalum Franch. in India are provided.
Vascular Cognitive Impairment Linked to Brain Endothelium Inflammation in Early Stages of Heart Failure in Mice
Authors: Adamski Mateusz G. , Sternak Magdalena , Mohaissen Tasnim , Kaczor Dawid , Wierońska Joanna M. , Malinowska Monika , Czaban Iwona , Byk Katarzyna , Lyngsø Kristina S. , Przyborowski Kamil , Hansen Pernille B.L. , Wilczyński Grzegorz , Chlopicki Stefan 
Published: March 2018

Background

Although advanced heart failure (
HF
) is a clinically documented risk factor for vascular cognitive impairment, the occurrence and pathomechanisms of vascular cognitive impairment in early stages of
HF
are equivocal. Here, we characterize vascular cognitive impairment in the early stages of
HF
development and assess whether cerebral hypoperfusion or prothrombotic conditions are involved.

Methods and Results

Tgαq*44 mice with slowly developing isolated
HF
triggered by cardiomyocyte‐specific overexpression of G‐αq*44 protein were studied before the end‐stage
HF
, at the ages of 3, 6, and 10 months: before left ventricle dysfunction; at the stage of early left ventricle diastolic dysfunction (with preserved ejection fraction); and left ventricle diastolic/systolic dysfunction, respectively. In 6‐ to 10‐month‐old but not in 3‐month‐old Tgαq*44 mice, behavioral and cognitive impairment was identified with compromised blood‐brain barrier permeability, most significantly in brain cortex, that was associated with myelin sheet loss and changes in astrocytes and microglia. Brain endothelial cells displayed increased E‐selectin immunoreactivity, which was accompanied by increased amyloid‐β
1‐42
accumulation in piriform cortex and increased cortical oxidative stress (8‐
OH
dG immunoreactivity). Resting cerebral blood flow measured by magnetic resonance imaging in vivo was preserved, but ex vivo
NO
‐dependent cortical arteriole flow regulation was impaired. Platelet hyperreactivity was present in 3‐ to 10‐month‐old Tgαq*44 mice, but it was not associated with increased platelet‐dependent thrombogenicity.

Conclusions

We report for the first time that vascular cognitive impairment is already present in the early stage of
HF
development, even before left ventricle systolic dysfunction. The underlying pathomechanism, independent of brain hypoperfusion, involves preceding platelet hyperreactivity and brain endothelium inflammatory activation.
RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up
Authors: Meybohm Patrick , Kohlhaas Madeline , Stoppe Christian , Gruenewald Matthias , Renner Jochen , Bein Berthold , Albrecht Martin , Cremer Jochen , Coburn Mark , Schaelte Gereon , Boening Andreas , Niemann Bernd , Sander Michael , Roesner Jan , Kletzin Frank , Mutlak Haitham , Westphal Sabine , Laufenberg‐Feldmann Rita , Ferner Marion , Brandes Ivo F. , Bauer Martin , Stehr Sebastian N. , Kortgen Andreas , Wittmann Maria , Baumgarten Georg , Meyer‐Treschan Tanja , Kienbaum Peter , Heringlake Matthias , Schoen Julika , Treskatsch Sascha , Smul Thorsten , Wolwender Ewa , Schilling Thomas , Fuernau Georg , Bogatsch Holger , Brosteanu Oana , Hasenclever Dirk , Zacharowski Kai , Stevanovic Ana , Rossaint Rolf , Felzen Marc , Goetzenich Andreas , Moormann Tobias , Chalk Katharina , Knuefermann Pascal , Recht Thomas , Hoeft Andreas , Winterhalter Michael , Iken Sonja , Wiedenbeck Carolin , Schwarzmann Gerhard , Lindau Simone , Zierer Andreas , Fichtlscherer Stephan , Goerlach Gerold , Wollbrueck Matthias , Boening Ursula , Weigand Markus , Strauchmann Julia , Morsbach Kai U. , Paxian Markus , Reinhard Konrad , Scholz Jens , Renner Jochen , Broch Ole , Francksen Helga , Kuhr Bernd , Heinze Hermann , Paarmann Hauke , Sievers Hans‐Hinrich , Klotz Stefan , Hachenberg Thomas , Werner Christian , Mauff Susanne , Alms Angela , Bergt Stefan , Roewer Norbert 
Published: March 2018

Background

Remote ischemic preconditioning (
RIPC
) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results of RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 cardiac surgery patients receiving either
RIPC
or sham‐
RIPC
.

Methods and Results

In this follow‐up paper, we present 1‐year follow‐up of the composite primary end point and its individual components (all‐cause mortality, myocardial infarction, stroke and acute renal failure), in a sub‐group of patients, intraoperative myocardial dysfunction assessed by transesophageal echocardiography and the incidence of postoperative neurocognitive dysfunction 5 to 7 days and 3 months after surgery.
RIPC
neither showed any beneficial effect on the 1‐year composite primary end point (
RIPC
versus sham‐
RIPC
16.4% versus 16.9%) and its individual components (all‐cause mortality [3.4% versus 2.5%], myocardial infarction [7.0% versus 9.4%], stroke [2.2% versus 3.1%], acute renal failure [7.0% versus 5.7%]) nor improved intraoperative myocardial dysfunction or incidence of postoperative neurocognitive dysfunction 5 to 7 days (67 [47.5%] versus 71 [53.8%] patients) and 3 months after surgery (17 [27.9%] versus 18 [27.7%] patients), respectively.

Conclusions

Similar to our main study,
RIPC
had no effect on intraoperative myocardial dysfunction, neurocognitive function and long‐term outcome in cardiac surgery patients undergoing propofol anesthesia.

Clinical Trial Registration

URL:
https://www.clinicaltrials.gov
. Unique identifier:
NCT
01067703.
A Stark Choice: Domestic Violence or Deportation?
Authors: Stoyanova Vladislava 
Published: March 2018

Abstract
The Council of Europe Convention on Preventing and Combating Violence against Women and Domestic Violence (the Istanbul Convention) is a relatively recent treaty that has the objective to protect women against all forms of violence and to design a comprehensive framework of measures for achieving this aim. Migrant women are of special concern given the awareness that when their migration status is dependent on that of their sponsoring spouse, they might be faced with a stark choice between staying in an abusive relationship or risking being deported. Article 59 (residence status) of the Convention is intended to respond to this problem by providing an immigration relief to migrant women victims of violence by carving out exceptions in the immigration control prerogatives of host states. Article 59 raises two interrelated questions: under what conditions are these exceptions triggered and what is their transformative potential in the light of the immigration rights that Article 59 extends to migrant women. This article argues that while the Istanbul Convention will generate some positive changes, the overall advancement triggered by the treaty in the area of protection of migrant women suffers from significant limitations.
Between Europe and Asia
Authors: Khodarkovsky Michael 
Published: March 2018

Abstract
This essay addresses an unusual knot of the Russian historiography: was Russia a colonial empire and if so, why did he authorities consistently refuse to identify the empire as such? I am providing some answers by examining the Russian empire in a broad comparative perspective of both European and Asian empires. In the end, the goal of this essay is to re-open a discussion on the nature of the Russian empire.
Was There a Riurikid Dynasty in Early Rus’?
Authors: Ostrowski Donald 
Published: March 2018

Abstract
This article explores the gap between the scholarly literature, which touts a Riurikid dynasty in Rus’ before the sixteenth century, and the primary sources of the time, which seem to be unaware of such a dynasty. The appeals to legitimacy in the primary sources for particular kniazi to rule in a town never resort to claiming descent from Riurik. Instead, such claims are based on whether one’s father ruled in that town. All others are izgoi, that is, outside the line of succession to any particular throne. The chronologies of the Povest’ vremennykh let and the Novgorod I Chronicle that declare Igor’ to be Riurik’s son are faulty and most likely derive from a single source. In the sixteenth century, Rus’ churchmen in an effort to shore up the legitimacy of the Daniilovichi, who should have been considered izgoi according to the Rus’ succession system, to rule in Moscow claimed descent of the Rus’ grand prince from Riurik and beyond him to Prus, a supposed kinsman of Augustus Caesar. Historians have accepted the dynastic claim of the sixteenth-century Rus’ churchmen to Rus’ kniazi being descended from Riurik (although not from Prus) and thus perpetuate the view that such a dynasty, and thereby a state, existed in early Rus’.
WUDAPT: An Urban Weather, Climate, and Environmental Modeling Infrastructure for the Anthropocene
Authors: Ching J. , Mills G. , Bechtel B. , See L. , Feddema J. , Wang X. , Ren C. , Brousse O. , Martilli A. , Neophytou M. , Mouzourides P. , Stewart I. , Hanna A. , Ng E. , Foley M. , Alexander P. , Aliaga D. , Niyogi D. , Shreevastava A. , Bhalachandran P. , Masson V. , Hidalgo J. , Fung J. , Andrade M. , Baklanov A. , Dai W. , Milcinski G. , Demuzere M. , Brunsell N. , Pesaresi M. , Miao S. , Mu Q. , Chen F. , Theeuwes N. 
Published: March 2018

AbstractThe World Urban Database and Access Portal Tools (WUDAPT) is an international community-based initiative to acquire and disseminate climate relevant data on the physical geographies of cities for modeling and analysis purposes. The current lacuna of globally consistent information on cities is a major impediment to urban climate science toward informing and developing climate mitigation and adaptation strategies at urban scales. WUDAPT consists of a database and a portal system; its database is structured into a hierarchy representing different levels of detail, and the data are acquired using innovative protocols that utilize crowdsourcing approaches, Geowiki tools, freely accessible data, and building typology archetypes. The base level of information (L0) consists of local climate zone (LCZ) maps of cities; each LCZ category is associated with a range of values for model-relevant surface descriptors (roughness, impervious surface cover, roof area, building heights, etc.). Levels 1 (L1) and 2 (L2) will provide specific intra-urban values for other relevant descriptors at greater precision, such as data morphological forms, material composition data, and energy usage. This article describes the status of the WUDAPT project and demonstrates its potential value using observations and models. As a community-based project, other researchers are encouraged to participate to help create a global urban database of value to urban climate scientists.
Energetics and Dynamics of Subtropical Australian East Coast Cyclones: Two Contrasting Cases
Authors: Cavicchia Leone , Dowdy Andrew , Walsh Kevin 
Published: March 2018

Abstract
The subtropical east coast region of Australia is characterized by the frequent occurrence of low pressure systems, known as east coast lows (ECLs). The more intense ECLs can cause severe damage and disruptions to this region. While the term “east coast low” refers to a broad classification of events, it has been argued that different ECLs can have substantial differences in their nature, being dominated by baroclinic and barotropic processes in different degrees. Here we reexamine two well-known historical ECL case studies under this perspective: the Duck storm of March 2001 and the Pasha Bulker storm of June 2007. Exploiting the cyclone phase space analysis to study the storms’ full three-dimensional structure, we show that one storm has features similar to a typical extratropical frontal cyclone, while the other has hybrid tropical–extratropical characteristics. Furthermore, we examine the energetics of the atmosphere in a limited area including both systems for the ECL occurrence times, and show that the two cyclones are associated with different signatures in the energy conversion terms. We argue that the systematic use of the phase space and energetics diagnostics can form the basis for a physically based classification of ECLs, which is important to advance the understanding of ECL risk in a changing climate.
The Deadliest Tornado (EF4) in the Past 40 Years in China
Authors: Meng Zhiyong , Bai Lanqiang , Zhang Murong , Wu Zhifang , Li Zhaohui , Pu Meijuan , Zheng Yongguang , Wang Xiaohua , Yao Dan , Xue Ming , Zhao Kun , Li Zhaoming , Peng Siqi , Li Liye 
Published: March 2018

Abstract
An EF4 supercellular tornado hit Funing County, Yancheng, Jiangsu Province, China, from about 1410 to 1500 local standard time 23 June 2016, causing 98 fatalities and 846 injuries. It was the deadliest tornado in the past 40 years in China. This paper documents the storm environment, evolution of the radar signatures, real-time operational tornado warning services, and the damage distribution during this event. The tornado was spawned from a supercell that developed ahead of an upper-level trough extending southwestward from a low pressure vortex in northeast China and dissipated following the occlusion of the tornado vortex. The radar-based rotational velocity of the mesocyclone peaked at 42.2 m s−1. The strength of the tornado vortex signature (gate-to-gate azimuthal radial velocity difference) peaked at 84.5 m s−1. Surface observations at 1-min intervals from a mesoscale network of in situ surface weather stations revealed the surface wind pattern associated with the mesocyclone, such as convergent and rotational flows. The tornado formed after the peak updraft strength of the supercell, producing a damage swath that was 34.5 km long and with a maximum width of 4.1 km. The review of the tornado warning process for this event reveals that there is much work to be done to develop operational tornado forecast and warning services for China.
Auditory Task Irrelevance: A Basis for Inattentional Deafness
Authors: Scheer Menja , Bülthoff Heinrich H. , Chuang Lewis L. 
Published: March 2018

Objective This study investigates the neural basis of inattentional deafness, which could result from task irrelevance in the auditory modality. Background Humans can fail to respond to auditory alarms under high workload situations. This failure, termed inattentional deafness, is often attributed to high workload in the visual modality, which reduces one’s capacity for information processing. Besides this, our capacity for processing auditory information could also be selectively diminished if there is no obvious task relevance in the auditory channel. This could be another contributing factor given the rarity of auditory warnings. Method Forty-eight participants performed a visuomotor tracking task while auditory stimuli were presented: a frequent pure tone, an infrequent pure tone, and infrequent environmental sounds. Participants were required either to respond to the presentation of the infrequent pure tone (auditory task-relevant) or not (auditory task-irrelevant). We recorded and compared the event-related potentials (ERPs) that were generated by environmental sounds, which were always task-irrelevant for both groups. These ERPs served as an index for our participants’ awareness of the task-irrelevant auditory scene. Results Manipulation of auditory task relevance influenced the brain’s response to task-irrelevant environmental sounds. Specifically, the late novelty-P3 to irrelevant environmental sounds, which underlies working memory updating, was found to be selectively enhanced by auditory task relevance independent of visuomotor workload. Conclusion Task irrelevance in the auditory modality selectively reduces our brain’s responses to unexpected and irrelevant sounds regardless of visuomotor workload. Application Presenting relevant auditory information more often could mitigate the risk of inattentional deafness.
Failed Honeymoon: Dilma Rousseff’s Third Election Round
Authors: Feres Júnior João , Sassara Luna de Oliveira 
Published: March 2018

In a test of the hypothesis of the existence of a honeymoon period in Brazil after Dilma Rousseff’s victory in the 2014 presidential election, a sentiment analysis of a large database composed of newspaper articles published by Brazil’s most influential quality newspapers, Folha de S. Paulo, O Globo, and Estado de S. Paulo, from January 2014 to August 2016, showed that negative coverage of her skyrocketed right after she took office and stayed very high until she was removed from power. Also tested was the hypothesis that the bias against Rousseff was simply a general disposition of the media to exert their watchdog function in the public interest through a comparison of her coverage with that received by Senator Aécio Neves, the losing candidate in the election and leader of the main opposition party and the campaign for her impeachment, who was the object of innumerable charges of corruption. This hypothesis was also rejected. A análise de valência de uma grande base de textos publicados pelos quality newspapers mais influentes do Brasil, Folha de São Paulo, O Globo e o Estado de S. Paulo, de janeiro de 2014 a agosto de 2016 demonstra que, após sua vitória na eleição presidencial de 2014, Dilma Rousseff não teve uma Lua de Mel por parte da grande imprensa. Pelo contrário, sua cobertura negativa se intensificou enormemente logo depois de assumir o cargo e ficou muito alta até sua remoção do poder. Também foi testada a hipótese de que o viés contra Rousseff fosse simplesmente uma disposição geral da mídia para exercer sua função de vigilância (watchdog) do interesse público frente aos políticos eleitos por meio da comparação de sua cobertura com aquela recebida por Aécio Neves, senador, candidato derrotado à presidência e líder da oposição e da campanha pelo impeachment de Dilma, e alvo de inúmeras acusações de corrupção. Tal hipótese também foi rejeitada pela análise dos dados.
CDE Pharmacists in the United States
Authors: Gonzalvo Jasmine D. , Lantaff Wendy M. 
Published: March 2018

Purpose The purpose of the study was to identify current practice settings for Certified Diabetes Educators (CDEs) who are pharmacists. Following nurses and dietitians, pharmacists are the third largest group of health professionals who hold the CDE credential. The growing number of CDE pharmacists highlights the increasing involvement of pharmacists in diabetes care. What remains unknown is the specific settings in which pharmacist CDEs practice. Methods A cross-sectional, nationwide electronic survey was sent to all CDE pharmacists in the United States. Questions regarding demographics, practice setting characteristics, certification information, and common diabetes-related counseling topics were asked of all respondents. Survey items also sought to determine pharmacists’ perceptions of the benefits and barriers to obtaining the CDE credential. The questions were dichotomous, Likert-scale response, or open-ended. Results A total of 462 survey responses were included in the analysis for a response rate of (462/1275) 36.2%. Respondents identified hospital or health system as the most common practice setting (n = 311), followed by academia (n = 100), community (n = 81), managed care (n = 44), and other settings. Conclusions Study findings provide important data that describe where CDE pharmacists are practicing to provide diabetes education. The continued steady growth of CDE pharmacists suggests a consistent increase of pharmacists practicing diabetes education. Diabetes educators should recognize that CDE pharmacists practice in a variety of different settings.