bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inclusion of Advanced Completions & Surveillance Data in History Matching and Utility of the Resulting Dynamic Models
Authors: Kasaraneni Pruthviraj , Al-Rashidi Tahani , Al-Zamanan Meshary , Ziyab Khaled , Bahuguna Rakesh 
Published: October 2019

Abstract
Traditionally most Reservoir Engineers give emphasis in matching Water-Cut, GOR, SBHP/FBHP and Cumulative Oil/Water & Gas production. Matching the above said will yield good results at the well level, however what is happening within the layers where the well is completed still remains unclear.
In addition to the conventional production data matching various well surveillance data like Pressure from the RFT data will enhance tracking of the Vertical/Aerial distribution of reservoir fluids. Matching PLT data will result in improving the relative contribution of different layers in the dynamic model. Capturing time-lapse changes of Water/Gas saturation as observed from the TDT/PNC logs in the model will mimic fluid flow and saturation changes in the dynamic model closer to reality. Identifying the amount of water unwantedly being injected in to the reservoir due to casing integrity and simulating its effect during history matching will help in capturing its impact on increasing water saturation and pressure near the well bore.
At the same time due to the complexity and the resultant convergence which arise in modeling advanced completions, typically a positive to skin at the well level is considered to achieve the additional pressure drop which is observed in the constriction (Nozzle) of the ICD. However the effect of flow equalization as a result of implementing ICD is missed in the above approach.
We propose a simplified approach by amalgamating the ICD's into an equivalent acting one. Using Amalgamation it is possible to compute the equivalent length and cross sectional area of an ICD that represents multiple ones. This reduces the number of ICDs in the model, avoids looped flow paths and correctly models annular flow along with great reduction in computational time and convergence.
After thoroughly matching the dynamic model with observed data, well-surveillance data and capturing the flow equalization impact of advanced completions during the long history of 57 years the level of confidence in the history match has increased significantly.
The history matched dynamic model is then used to generate Stream Lines to establish well pair interactions and identify the movement of injected water to optimize injection/production targets. Precisely capturing movement of OWC and tracking the size of Gas-Cap with time has significantly improved the confidence in planning wells. Wells locations thus released on the basis of model results show a good replication of forecasted saturation's and are so far doing well.
Mitigation of Structural Uncertainty in High Angled Dipping Up Middle Marrat Reservoirs With the Help of Deep Electro-Magnetic Inversion Geosteering Technique, Calibrating With Seismic Data- A Case Study, Umm Gudair Field, West Kuwait
Authors: Ray Dipak Singha , Al-Shamali Adnan , Quttainah Riyad , Keot Chandan Jyoti , Noreldeen Salih Abdalla 
Published: October 2019

Abstract
The Umm Gudair field is an elongated doubly plunging anticline which bifurcates into two branches NS elongated West UG and the NE-SW elongated East UG structures with a broad saddle in between Fig1A & 1B. West Umm Gudair structure was formed during the Jurassic time and become reactivated in Cretaceous and Tertiary times. East Umm Gudair was formed during Cretaceous as evident from the thicker deposition of overlying Gotnia sediments and its unique fold geometry.
A total of 28 wells targeting Najmah-Sargelu (NJ/SR) & Marrat reservoirs of Jurassic have been drilled so far in this field including one deep well in South UG in Divided Zone
The Marrat Formation in Umm Gudair field is conventional reservoir with 800ft to 1000ft thick sequence comprising limestone, dolomitic limestone and argillaceous limestone with minor shale and anhydrite. The Jurassic sequence in Kuwait oil fields starts from around 12000ft and is marked by an increase in formation pressure and temperature. Above this lies the Cretaceous sequence where most of the oil field development works have been concentrated in the past. In the last two decades field development has extended to the Jurassic sequence to meet up with increasing production demands. The Jurassic sequence is marked by a series of high pressure and high temperature formations with presence of natural fractures.
Insights on Single Well Chemical Tracer Testing Beyond Oil Saturation Changes
Authors: Al Murayri Mohammed T. , Kamal Dawood S. , Al-Fadhli Atheer A. , Pitts Malcolm , Wyatt Kon , Dean Elio 
Published: October 2019

Abstract
Single Well Chemical Tracer Testing (SWCTT) is traditionally performed to determine oil saturation after waterflooding and after enhanced oil recovery techniques. Raudhatain Lower Burgan (RALB) and Sabriyah Lower Burgan (SALB) SWCTT oil saturation reduction due to injection of surfactant-polymer and alkali-surfactant solutions, respectively, were 7 and 8% OOIP, respectively. During SWCTT, injection rate and surface pressure are routinely measured for each injected solution. Injection rate and surface pressure permit additional determinations to be made as outlined below: Pseudo resistance factor to any fluid "i" can be calculated and, from this, changes in injectivity can be determinedFlowing viscosity of injected fluids relative to waterEffective permeability to injected fluidsInjectivity factors
Pseudo resistance factor for RALB continually increased with seawater injection, from 0.5 to 1.0 indicating a reduction of kwro to approximately half and a twofold loss of injectivity. SALB kwro showed a three-fold loss of injectivity with seawater injection (pseudo resistance factor increased to 1.0 from 0.36). RALB pseudo residual resistance factor was 6.0 indicating a six-fold loss of injectivity due to surfactant-polymer and polymer drive solution injection even though the oil saturation was reduced by 7% OOIP. SALB pseudo resistance factor increased to 1.7 during alkaline-surfactant solution, indicating a loss of injectivity and an increase in flowing viscosity. SALB pseudo residual resistance factors were 0.89 to 1.06 suggesting no damage to reservoir rock and no loss to a slight increase of injectivity or an increase of kwro after an 8% OOIP saturation reduction. RALB surfactant-polymer rheometer viscosity was 0.55 cP while flowing viscosity was 0.21 cP as calculated from pseudo resistance factor data with the comparative polymer drive solution viscosities being 1.9 cP rheometer and 0.16 cP flowing. SALB alkaline-surfactant solution flowing viscosity was calculated to be 0.80 cP compared to water viscosity of 0.50 cP. Calculated SALB kwro values for injection of water, alkaline-surfactant, and water flush after alkaline-surfactant are 0.012, 0.007, and 0.011 to 0.015mD, respectively. Calculated RALB kwro values for injection of seawater and seawater flush after surfactant-polymer/polymer flush are 0.019 and 0.004 mD.
Minimally invasive versus conventional fixation of tracer in robot-assisted pedicle screw insertion surgery: a randomized control trial
Authors: Yongqi Li , Dehua Zhang , Hongzi Wu , Ke Zhang , Rui Yang , Zhou Fang , Shaobo Wang , Liao Yi 
Published: October 2019

Abstract
Background This study evaluated the minimal invasiveness, safety, and accuracy of robot-assisted pedicle screw placement procedure using a modified tracer fixation device. Methods Patients were randomly assigned to conventional fixation group (25 patients) and modified fixation group (27 patients). Results No baseline statistical difference was observed between the groups ( P >0.05). The length of unnecessary incision, amount of bleeding, and fixation duration for tracer fixation respectively were 6.08±1.02 mm, 1.46±0.84 ml, and 1.56±0.32 min in the modified fixation group and 40.28±8.52 mm, 12.02±2.24 ml, and 5.08±1.06 min in the conventional group. The difference between both groups was significant ( P <0.05). However, no significant difference between the two groups was observed in terms of the accuracy of pedicle screw placement ( P >0.05). Conclusions The modified minimally invasive procedure for tracer fixation results in minimal trauma and is simple, reliable, and highly safe. Additionally, the procedure does not compromise the accuracy of pedicle screw placement. Thus, it has great clinical applicable value.
Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial
Authors: Cai Hua , Qin Yue-Lan , Shi Ze-Ya , Chen Jin-Hui , Zeng Min-Jie , Zhou Wei , Chen Ru-Qun , Chen Zhi-Yuan 
Published: October 2019

Abstract
Background: Alternate-day fasting (ADF) is a novel diet therapy that may achieve reduction in body weight and improvement of dyslipidaemia, but the impact of this diet on patients with non-alcoholic fatty liver disease (NAFLD) remains unknown. The aim of this study was to evaluate the effects of ADF on the body weight and lipid profile of individuals with NAFLD. Methods: NAFLD patients (n=271) were randomised to the ADF group, time-restricted feeding (TRF) group, or the control group and subjected to the respective diet for 12 weeks. Anthropometric measurements (body weight, fat mass/fat-free mass) were performed, and plasma lipids were analysed enzymatically. Results: Within 4 weeks, the body weight decreased significantly (P<0.001) in the ADF group by 4.56±0.41 kg (6.1 ± 0.5%) and the TRF group by 3.62±0.65 kg (4.83±0.9%) compared to the control group, and it decreased even more after 12 weeks in both groups (ADF: -4.04±0.54 kg, 5.4±0.7%; TRF: -3.25±0.67 kg, 4.3±0.9%). Fat mass was significantly reduced by ADF (-3.49±0.37 kg; 11±1.2%) and TRF (-2.91±0.41 kg; 9.6±1.3%), with ADF leading to a further reduction in fat mass after 12 weeks (-3.48±0.38 kg; 11±1.2%). Total cholesterol was significantly decreased at both time points in the ADF group (-0.91±0.07 mmol/L; 18.5±1.5%) compared to the control and TRF groups. Both ADF (-0.64±0.06 mmol/L; 25±1.9%) and TRF (0.58±0.07 mmol/L; 20±1.7%) achieved a significant reduction in serum triglycerides (P<0.001) after 12 weeks. Changes in fat free mass, HDL, LDL, fasting insulin, glucose, and systolic or diastolic blood pressure did not differ between the groups. Conclusions: ADF appears to be an effective diet therapy for individuals with NAFLD that can achieve weight loss and improvement of dyslipidaemia within a relatively short period of time (4 to 12 weeks). Potential preventive effects of ADF on cardiovascular disease need to be confirmed by future investigations. Trial registration: ChiCTR1900024411, this trial was retrospectively registered on July 10, 2019
Post-hospital medical respite care for homeless people in Denmark: A randomized controlled trial and cost-utility analysis.
Authors: Bring Camilla Nygaard , Kruse Marie , Ankarfeldt Mikkel , Brünés Nina , Pedersen Maja , Petersen Janne , Andersen Ove 
Published: October 2019

Abstract
Background: Being homeless entails higher mortality, morbidity, and prevalence of psychiatric diseases. This can lead to more frequent and expensive use of health care services. Medical respite care enables an opportunity to recuperate after a hospitalization and has shown a positive effect on readmissions, but little is known about the cost-effectiveness of medical respite care for homeless people discharged from acute hospitalization. Therefore, the aim of the present study was to investigate the cost-effectiveness of a 2-week stay in post-hospital medical respite care. Methods: A randomized controlled trial and cost-utility analysis, from a societal perspective, was conducted between April 2014 and December 2015. Homeless people aged >18 years with an acute admission were included from 10 different hospitals in the Capital Region of Denmark. The intervention group (n=53) was offered a 2-week medical respite care stay at a Red Cross facility and the control group (n=43) was discharged without any extra help (usual care), but with the opportunity to seek help in shelters and from street nurses and doctors in the municipalities. The primary outcome was the difference in health care costs 3 months following inclusion in the study. Secondary outcomes were change in health-related quality of life and health care costs 6 months following inclusion in the study. Data were collected through Danish registries, financial management systems in the municipalities and at the Red Cross, and by using the EQ-5D questionnaire. Results: After 3 and 6 months, the intervention group had €4,761 (p=0.10) and €8,515 (p=0.04) lower costs than the control group, respectively. The higher costs in the control group were mainly related to acute admissions. Both groups had minor quality-adjusted life year gains. Conclusions: This is the first randomized controlled trial to investigate the cost-effectiveness of a 2-week medical respite care stay for homeless people after hospitalization. The study showed that a medical respite care stay for homeless people is cost-effective. Furthermore, this study illustrates that it is possible to perform research with satisfying follow-up with a target group that is hard to reach. Trial registration: ClinicalTrials.gov Identifier: NCT02649595
Changing Medical Education Scenario: A wakeup call for reforms in Anatomy Act
Authors: Lalwani Rekha , Kotgirwar Sheetal , Athavale Sunita A. 
Published: October 2019

Abstract
Background Anatomy Act provides legal ambit to medical educationist for the procurement of cadavers. The changing medical education scenario and socio-demographic change has necessitated an urgent review of the concerned legal framework. Suitable amendments addressing the current disparities and deficiencies are long overdue. Methods Anatomy Act in India is a state act and which ensures provision of unclaimed /donated bodies for Medical Education and research. The methodology included three components namely: Comparison of various Anatomy Acts clause by clause; Feedback from anatomist; Formulation of comprehensive model Anatomy Act. Results Various acts studied showed discrepancies in purpose of the act, roles and duties of stake holders, regulation for body donation, procedure to handle unclaimed bodies, disposal of dissected bodies etc. None of the acts defines a donor and neither addresses the issue of transport of anatomical material. Only ten states have a clause for body donation. Acts of only six states have been amended over last 50 years. Three states denied having an act. The whole exercise of review of acts and extensive feedback received from end-users culminated in drafting of a comprehensive model Anatomy act. Conclusion India, with the largest number of medical colleges is not only at forefront but also a hub of medical education in Southeast Asia region. A legal reform can be a torch bearer for other countries of the region with similar socio-demography and shall motivate anatomic fraternity across the globe for critical analysis of their respective anatomy acts. Keywords : Cadaver; Dissection; Medical Education; Southeast Asia.
Steep decline of HPV 6 and genital warts despite low HPV vaccination coverage in young women in Germany: a long-term, population-based cohort study
Authors: Denecke Agnieszka , Iftner Thomas , Iftner Angelika , Riedle Sebastian , Ocak Marion , Luyten Alexander , Üye Isak , Tunc Kübra , Petry Karl Ulrich 
Published: October 2019

Abstract
Background: The introduction of human papilloma virus (HPV) vaccination has resulted in a remarkable decline of genital warts in women and men, but in Germany historical rates of vaccination are relatively low. We report long-term surveillance data on changes in HPV 6 and 11 infection and the prevalence of genital warts in young women in the Wolfsburg HPV epidemiological study (WOLVES).Methods: Women born in 1983/84, 1988/89, and 1993/94 participated in four cohorts between 2009/10 and 2014/15. Vaccination coverage and prevalence of HPV 6/11 and genital warts are reported for participants aged 19−22 years and 24−27 years at the time of analysis. Statistical analyses were done to compare similarly aged participants using 2 x 2 contingency tables (Röhmel-Mansmann unconditional exact test; two-side alpha of 0.05).Results: A total of 2,456 women were recruited. In 2010, vaccination rates were 40/659 (6.1%) in women aged 24−27 years and 142/600 (23.7%) in those aged 19−22 years; 5 years later, vaccination rates had increased to 135/733 (18.4%) and 177/368 (48.1%), respectively. Between 2010 and 2015, there was a statistically significant decrease in the prevalence of HPV 6 among women aged 24−27 years (2.12% versus 0%; P<0.0001) and women aged 19−22 years (2.0% versus 0%; P=0.0056). In total, 52 of 2341 participants were diagnosed with genital warts. There was a statistically significant decrease in the life-time risk of developing genital warts in women aged 24−27 years between 2010 and 2015 (4.7% versus 1.68%, respectively; P=0.0018). The overall life-time risk of developing genital warts in women aged 19−27 years decreased from 3.1% in 2010 to 1.2% in 2015 (P=0.0022).Conclusions: An increase in vaccination coverage was associated with a decreased prevalence of genital warts in young women. A protective effect greater than herd immunity alone was seen despite low vaccination rates. Quadrivalent vaccine had a protective effect on genital HPV 6 positivity and a fully protective effect on the development of genital warts in the youngest population.
Comprehensive Analysis of mRNAs and miRNAs in the Ovarian Follicles of Uniparous and Multiple Goats at Estrus Phase
Authors: Zou Xian , Lu Tingting , Zhao Zhifeng , Liu Guangbin , Lian Zhiquan , Guo Yongqing , Sun Baoli , Liu Dewu , Li Yaokun 
Published: October 2019

Abstract
Background Fertility is an important economic trait in production of meat goat, and follicular development plays an important role in fertility. Despite many mRNAs and microRNAs (miRNAs) have been found in playing critical roles in ovarian biological processes, the interactions between mRNAs and miRNAs in follicular development is not yet completely understood. In addition, less attention has been given to the single follicle (dominant or atretic follicle) in goat. The study was aimed to identify mRNAs, miRNAs and signaling pathways as well as their interaction networks in the ovarian follicles (large follicles and small follicles) of multiple and uniparous goats (Chuanzhong Black Goats) at estrus phase by using a deep RNA-sequencing (RNA-seq) method.Results The result showed that there were more large follicles in multiple than in uniparous goats ( P <0.05), while no difference was observed in small follicles between them ( P >0.05). For the small follicles of multiple and uniparous goats at estrus phase, 289 differentially expressed mRNAs (DEmRNAs) and 16 DEmiRNAs were identified; and for the large follicles, 195 DEmRNAs and 7 DEmiRNAs were identified. Ovarian steroidogenesis and steroid hormone biosynthesis were significantly enriched in small follicles, while ABC transporters and steroid hormone biosynthesis in large follicles. The results of qRT-PCR were generally consistent with the RNA-seq data. The mRNA-miRNA interaction network showed that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b) and PTGFR (miR-182, miR-122) might be related to fertility, but need further verification.Conclusion This study provides the first identification of the DEmRNAs and DEmiRNAs as well as their interactions in the follicles of multiple and uniparous goats at estrus phase by using RNA-seq technology. These analyses provide new clues to uncover molecular mechanisms and signaling networks of goat reproduction which could be potentially used to increase ovulation rate and kidding rate in goat.
Accessibility and utilization of modern health care among rural community in Ethiopia: The case of Bako district, Western Oromia: Community based descriptive cross-sectional study
Authors: Abdisa Tadesse Abdisa , Desalegn Zelalem , Cheme Melese Chego 
Published: October 2019

Abstract
Objectives: Knowing determinants of health seeking behaviors of families is significant in assuring access and utilization of health services. Less is known on the seeking behaviors and access of modern health services among populations in rural settings in Ethiopia. The general Objective of the study is to assess health care seeking behavior (Utilization) and associated factors among the community of in Bako Tibe District, Ethiopia. Community based descriptive cross-sectional study design was used on 750 head of the residents of ≥18 years old. Multistage sampling technique was used to get the households and data was collected by interview using structured questionnaire and analyzed using SPSS version 24. Binary and multiple logistic regression analysis were used to identify the factors associated with the health seeking behavior. Results: 495(66%) reported having morbidity and level of health care seeking behavior was 78.6% of which 66% sought care from government facilities. Sex of respondent, residence, family size, educational status, monthly income, disease condition, Perceived severity & access to needed health information were found to be significant associated factors of healthcare seeking behavior of the respondents in multiple logistic regression analysis. Keywords: Health seeking behavior, Access, Bako district, Ethiopia
Molecular characterization, expression and functional analysis of acyl-CoA-binding protein gene family in maize (Zea mays)
Authors: Zhu Jiantang , Li Weijun , Zhou Yuanyuan , Pei Laming , Liu Jiajia , Xia Xinyao , Che Ronghui , Li Hui 
Published: October 2019

Abstract
Background: Acyl-CoA-binding proteins (ACBPs) have a conserved acyl-CoA-binding (ACB) domain which facilitates binding to the acyl-CoA ester and trafficking in eukaryotic cells. Although the various functions of ACBP have been characterized in several plant species, its structural features, molecular evolution, expression profiling and function in Zea mays L . are still not clear. Results: Genome-wide analysis identified nine ZmACBP genes in Z. mays , which were divided into four groups (class I, class II, class III, and class IV) by a phylogenetic tree constructed with 48 ACBP genes from six plant species. The subcellular localizations of the ZmACBPs were displayed subcellular multi-localization via transient expression of green fluorescence protein (GFP) fusions in tobacco ( Nicotiana tabacum ) epidermal cells. The expression profiles of ZmACBPs are dramatically different in different organs and normal growth, as well as abiotic or biotic stress by Quantitative RT-PCR (qRT-PCR). Eight of nine ZmACBP genes located in metaQTL regions associated with agronomic traits in maize. The heterologous constitutive expression of ZmACBP1 and ZmACBP3 in Arabidopsis enhanced the resistance to salinity and osmotic stress. Conclusion: The ACBP genes family in Z. mays were highly conserved. ZmACBP genes had clear tissue and organ expression preference and were involved in abiotic or biotic stress response, suggesting their roles in plant growth and stress resistance.