bluuebunny/crossref_metadata_2025_split huggingface dataset:
BGData - A Suite of R Packages for Genomic Analysis with Big Data
Authors: Grueneberg Alexander , de los Campos Gustavo 
Published: March 2019

Abstract
We created a suite of packages to enable analysis of extremely large genomic data sets (potentially millions of individuals and millions of molecular markers) within the R environment. The package offers: a matrix-like interface for .bed files (PLINK’s binary format for genotype data), a novel class of linked arrays that allows linking data stored in multiple files to form a single array accessible from the R computing environment, methods for parallel computing capabilities that can carry out computations on very large data sets without loading the entire data into memory and a basic set of methods for statistical genetic analyses. The package is accessible through CRAN and GitHub. In this note, we describe the classes and methods implemented in each of the packages that make the suite and illustrate the use of the packages using data from the UK Biobank.
Hydrological characteristics of lakes in the eastern part of the Broknes Peninsula, Larsemann Hills, East Antarctica
Authors: Boronina A. S. , Popov S. V. , Pryakhina G. V. 
Published: March 2019

Broknes Peninsula (the area of the Progress station, Larsemann Hills, Princess Elisabeth Land, East Antarctica) is characterized by the presence of well developed hydrographic network consisting of reservoirs located not only in the bedrock, but also inside the glacier thickness and on its surface. As a rule, most of them are dammed by natural snowice weirs, which are often destroyed during the Antarctic summer. As a result of this process, glacial water outburst may occur. In the course of the summer season of the 63‑th Russian Antarctic Expedition (RAE) intensive hydrological field observations were carried out for identification and comprehensive investigation of potentially outburstprone reservoirs located in close proximity to Russian and foreign stations and field bases (area of the Progress station and the field base Law-Racovita). The works included: the organization of temporary pile and depth-stick water gauge stations, mapping positions of the shoreline of lakes (reservoirs), bathymetric surveys of them, as well as field hydro-chemical express analyses. Based on the results of the level measurement, it was found that most of the lakes of the oasis are characterized by a sharp drop in the height of the water surface level associated with the breakthroughs. In particular, the authors witnessed the breakthrough of the Discussion Lake, which occurred on January 22, 2018. This resulted in decrease of the water level by 0.95 m. Based on the data of the bathymetric surveys, the morphometric (hydrometric) characteristics of the lakes were calculated and detailed grids (regular net of rectangular matrices, in the nodes of which some effective values of the mapped values are located) were formed for the following numerical modeling of hypothetical and real breakthroughs of water bodies and construction of estimated hydrographs.
Winter air temperature in Holocene reconstructed from the ice wedges stable water isotopes near Anadyr town
Authors: Budantseva N. A. , Vasil'chuk Yu. A. 
Published: March 2019

The object of research is syncryogenic Holocene strata on the coast of the Onemen Bay, 2 km from the town of Anadyr. In July 2017, the outcrop of the first marine terrace uncovered by strong storms was examined. The stratigraphy of the outcrop was represented mainly by sandy loam (5–7 m thick) covered by peat (1–1.5 m) and underlain by sand. Numerous ice wedges were opened in the upper part of this outcrop. Along with that another outcropping of transect of a lakemarsh basin represented by a peat bog of 2–2.5 m thick underlain by sandy loam was also investigated. Ice wedges occur below the polygonal trenches. The present-day narrow ice wedges were found in the upper part of the peat bog. Two representative fragments of both the above outcrops were thoroughly examined. Radiocarbon dating had shown that accumulation of peat on surface of the first marine terrace started in early Holocene (about 8 ka BP). Accumulation of peatland within the lake-marsh basin was also dated to the beginning of the Holocene (about 9 ka BP). In the middle of the Holocene, it was most likely interrupted as a result of thermokarst processes and bogging of the surface. Formation of peatlands in Chukotka during the Holocene is known to be accompanied by active growth of the ice wedges inside them, so the age of the wedges studied by us was estimated as the beginning of the Holocene. The analysis of stable oxygen and hydrogen isotopes in the Holocene and the modern ice wedges had allowed establishing mainly the atmospheric type of moisture feeding of the wedges (due to melted snow) and lack of noticeable isotope fractionation during the ice formation. It has been found that δ18О and δ2Н values in the Holocene ice wedges were lower than in the modern wedges and snow by an average 2–3 and 7–12 ‰, respectively. Paleotemperature reconstructions performed on the basis of isotopeoxygen data showed that the air temperature of the coldest winter month in the first half of the Holocene in the Onemen Bay area was lower than the present-day ones by an average 2–3 °C, which is in a good agreement with the trend of rising winter temperatures throughout the Chukotka Peninsula, as well as in other areas of Eastern Siberia and Alaska.
Mina Wisata Sebagai Alternatif Pengembangan Wisata Bahari di Kawasan Pesisir Buleleng, Bali Utara
Authors: Yudasmara Gede Ari 
Published: March 2019

Kawasan pesisir Kabupaten Buleleng saat ini telah dimanfaatkan dengan berbagai kegiatan kepariwisataan, akan tetapi kegiatan tersebut masih belum memberikan manfaat yang optimal bagi masyarakat dan memiliki kecenderungan mengalami kejenuhan. Untuk itu, diperlukan suatu pengembangan wisata alternatif yang sesuai dengan kondisi dan potensi sumber daya alam yang ada serta saling bersinergi dengan aktivitas wisata lainnya, seperti contohnya pengembangan mina wisata. Penelitian ini bertujuan untuk mengkaji dan menganalisis kondisi dan potensi sumberdaya alam pesisir dan laut, tingkat kesesuaian kawasan pesisir Buleleng dalam menunjang pengembangan mina wisata dan menghasilkan model aktivitas mina wisata di kawasan pesisir Buleleng yang terpadu dan berkelanjutan. Penelitian ini menggunakan pendekatan kesesuaian kawasan dengan rancangan penelitiannya berupa survei lapangan. Hasil penelitian menunjukkan bahwa pesisir Kabupaten Buleleng apabila dilihat dari kondisi dan potensi sumberdaya alamnya masih mampu untuk mendukung aktivitas mina wisata dengan tingkat kesesuaian kawasan berdasarkan indeks kesesuaian wisata, yaitu pesisir Buleleng timur terkategori cukup sesuai (76,92), pesisir Buleleng tengah terkategori cukup sesuai (61,53) dan pesisir Buleleng barat terkategori sangat sesuai (87,17). Rencana model mina wisata yang dapat dikembangkan antara lain pesisir Buleleng timur adalah mina wisata budidaya laut (ikan hias dan karang) dan mina wisata perikanan tangkap (mancing dan spearfishing adventures), pesisir Buleleng tengah adalah mina wisata budidaya laut (rumput laut) dan mina wisata perikanan tangkap (mancing dan spearfishing adventures), dan pesisir Buleleng barat adalah mina wisata budidaya laut (rumput laut, Bandeng, Kerapu, Mutiara, ikan hias dan karang) dan mina wisata perikanan tangkap (mancing dan spearfishing adventures).
Some pileate fungus new collections in the Ngoc Linh mountain, Quang Nam province
Authors: Phu Tran Thi , Kiet Trinh Tam 
Published: March 2019

We identified and documented 8 spicies as new to macrofungi of Vietnam, of 7 genus, 7 family, 4 ordo, belonging to classes of Agaricomycetes, of which 2 species of edible mushrooms, 3 species poisonous mushrooms and 3 species of wood destruction, quickly formed humus for the soil environment..
New species recorded for the large fungal colonies of Vietnam have been studied for morphological and microscopic characteristics.
Asymptotically J_σ-Equivalence of Sequences of Sets
Authors: ULUSU Uğur , GÜLLE Esra 
Published: March 2019

In this
study, we introduce the concepts of Wijsman asymptotically J-invariant equivalence (WLJσ) , Wijsman asymptotically strongly p-invariant equivalence ([WLVσ)]p) and Wijsman asymptotically J*-invariant equivalence (WLJ*σ). Also, we investigate the relationships among the concepts
of Wijsman asymptotically invariant equivalence, Wijsman asymptotically
invariant statistical equivalence, WLJσ, [WLVσ)]p and WLJ*σ.
Enseñanza de idiomas: objetivos y técnicas de corrección en producción oral
Authors: Estrada Chichón José Luis 
Published: March 2019

Objetivo El objetivo era analizar la relación entre las técnicas de corrección explícitas/implícitas para errores orales en dirección productiva y los objetivos docentes de forma y significado en contextos de enseñanza de idiomas y Aprendizaje Integrado de Contenido y Lenguas Extranjeras (AICLE), Metodología desarrollada La metodología se articuló a partir de la recogida de datos en forma de errores orales (N=147) y las pertinentes intervenciones correctivas docentes. Para ello, se observaron clases de idiomas y AICLE (N=36) en un colegio privado de Madrid (España) en los seis cursos de Educación Primaria, Resultados Los resultados revelaron una preferencia generalizada entre ambos grupos de profesores a favor de técnicas de corrección explícitas cuyo objetivo era la forma de la lengua meta. Sin embargo, los profesores AICLE optaron también por intervenir sobre el significado cuando empleaban técnicas de corrección implícitas, Conclusiones y discusiones La conclusión principal giró en torno a la aplicación generalizada de técnicas de corrección explícitas, junto a la forma de la lengua meta como primer objetivo docente. Si bien, el enfoque AICLE también contempla la opción inversa. Esta situación puede extrapolarse al aula de idiomas mediante la aplicación contextualizada de usos lingüísticos con fines auténticamente adquisitivos.
Amplitude of Elastic Scattering for the Region of Large Impact Parameters
Authors: ABDULVAHABOVA Sajida G. , BARKHALOVA N.sh. , BAYRAMOVA T.o. 
Published: March 2019

The work is dedicated to consequences of analyticity and unitarity of
the scattering amplitude. Using the
Gaussian quasipotential an equation for the scattering amplitude matrix is
obtained and formula is derived for the cross sections. The dependence of the
cross section and ratio of the real part of the amplitude in the forward
scattering to its imaginary part of on the momentum are discussed. The steep
Gaussian peak for cross section at small angles is followed by the exponential
(Orear) regime. Results from theoretical approach are compared with
experimental data.
Kansere Yeni Yaklasim: Akciger Kanserinde İn Vitro Antianjiyogenik Tedavi
Authors: ALPAY Merve 
Published: March 2019

Amac: Anjiyogenez,
endotelyal hücreler, malign durumlardaki tümör hücrelerinin yanı sıra kemik
iliği kaynaklı hücreler ve stromal hücreleri içeren tumor mikrocevresindeki
hucreleri kapsayan çok faktörlü ve çok hücreli bir kompleks (pato-)fizyolojik
olaydır. Bu olayin ana faktoru, vasküler endotelyal büyüme faktörüdür (VEGFA).
Son yillarda tümör hücrelerinde potansiyel damarlanma sinyalini bloke etmek
icin VEGFA reseptorune karsi bevacizumab (anti-VEGF) ajani kullanilmaktadir ve akciğer
kanseri (NSCLC), kolorektal kanser, meme kanseri ve renal hücreli karsinomada
in vitro deneylerle farkli etkinlikleri belirlenmistir. Bu calismadaki temel
hedef, Bevacizumab uygulanmis akciger kanser hucrelerinde damarlanma etkinligi
ve mekanizmasinin normal hucrelerle karsilastirilarak belirlenmesidir. Gerec ve yontemler:
Ana uyarici VEGF ve anjiyogenez blokajini saglayan Bevacizumab uygulamalari ile
hucre fonksiyonlari incelendi. Normal epithelial HUVEC hatti ile akciger kanser
A549 hucre hatti kullanildi ve ATCC protokolune gore kulture edildi. Farkli
dozlarda ajanlar uygulandiktan sonra, hucre canliligi, Sytox cogalma indeksi ve
anjiyogenezden sorumlu basamak Notch etkinligi arastirildi. Bulgular: VEGF
ile muamele edilen hucrelerde 24 saat inkubasyon ile hucre canliliginda
belirgin artis saptandi. Iki hucre hattinda canlilik duzeyleri
karsilastirildiginda VEGF etkisinin anlamli derecede farkli oldugu goruldu. Bevacizumab uygulamasinda ise, A549
hucrelerinin cogalma indeksi anlamli derece azaldi ve Notch mekanizmasi ile iliskili
ADAM10 protein duzeyinin, HUVEC hucresine gore anlamli artis gosterdigi tespit
edildi.

Sonuc: Elde edilen bulgulara gore anjiyogenez molekuler
mekanizmasinin aciklanmasi adina daha detayli calismalara ihtiyac oldugu
gorulmektedir. Geleneksel kanser tedavi yontemleri yani sira etkisi bilinen
antianjiyogenik ajanlarla kombine tedavilerin arttirilmasi basari sansini
arttiracaktir
Kolagen dari Limbah Tulang Ayam (Gallus gallus domesticus) terhadap Aktivitas Anti Aging secara In Vitro
Authors: Budiarti Eka , Budiarti Perlambang , Aristri Manggar Arum , Batubara Irmanida 
Published: March 2019

<p>Limbah tulang ayam meningkat seiring dengan peningkatan konsumsi ayam. Namun, belum banyak penelitian yang memanfaatkan limbah tulang sebagai sumber kolagen. Penelitian ini bertujuan mengetahui pengaruh ukuran kolagen terhadap aktivitas anti aging berupa aktivitas antioksidan, antiglikasi, dan inhibitor tirosinase secara <em>in vitro</em> dan mendapatkan teknik isolasi kolagen <em>anti aging</em> optimum dari tulang ayam. Isolasi kolagen dilakukan dengan variasi konsentrasi NaOH, yaitu 0,05 M; 0,10 M; dan 0,20 M, dilanjutkan dengan perendaman menggunakan asam asetat 1 M. Kolagen yang diisolasi dengan NaOH 0,10 M merupakan kolagen dengan ukuran partikel, rendemen, dan antiglikasi terbesar (berturut-turut 2,34 µm, 12,59%, 61,06%) dan memiliki spektrum inframerah yang paling sesuai dengan kolagen standar. Kolagen ini kemudian diaduk dengan kecepatan 1000 rpm selama 6 dan 8 jam untuk pengecilan ukuran. Kolagen dengan pengadukan 6 jam mempunyai ukuran partikel lebih kecil (1,34 µm) dibandingkan dengan pengadukan 8 jam (1,80 µm). Kolagen dengan ukuran 1,34 µm menunjukkan aktivitas terbaik yaitu aktivitas antioksidan terhadap 2,2-difenil-1-pikrilhidrazil (DPPH) sebesar 24,70% dan inhibitor tirosinase sebesar 26,77%. Berdasarkan aktivitas antioksidan, antiglikasi, dan antitirosinase, kolagen dengan perendaman NaOH 0,10 M dan pengadukan selama 6 jam memiliki sifat anti aging yang paling baik.</p><p><strong><strong>In Vitro Anti-Aging Activity of Chicken (<em>Gallus gallus domesticus</em>) Bone Waste Collagen</strong>. </strong>Chicken bone waste increases with increasing chicken compsumtion. However, study on utilizing chicken bone for collagen source has not been widely explored. This study aims to determine the effect of collagen size on their anti aging activity, and to obtain the optimum condition to produce the chicken (<em>Gallus gallus domesticus</em>) collagen in the high yield and the best activity. Collagen isolation was carried out in various NaOH concentrations of 0.05 M, 0.10 M, and 0.20 M, followed by the maceration on acetic acid 1 M. The isolation in NaOH 0.10 M produced the collagen with particle size of 2.34 µm in yield of 12.59% and anti-glycation of 61.06%. The revealed infrared spectrum of the isolated collagen is almost the same with the spectrum of the standart collagen. The collagen in 2.34 µm was further stirred at a 1000 rpm for 6 and 8 hours to reduce the size. Collagen stirred in 6 hours has a smaller particle size (1.34 µm) compared with that of stirred in 8 hours which has a particle size of 1.80 µm. The collagen with size of 1.34 µm showed the best activity, which revealed the antioxidant activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) of 24.70% and tyrosinase inhibitors of 26.77%. Based on antioxidant activity, anti-glycation, and anti-tyrosinase, the collagen which was isolated in 0.10 M NaOH and was stirred in 6 hours has the best anti-aging property.</p>
Third Parties (Venue Owners, Managers, Security, etc.) and Access to Occupational Health and Safety Among Sex Workers in a Canadian Setting: 2010–2016
Authors: McBride Bronwyn , Goldenberg Shira M. , Murphy Alka , Wu Sherry , Braschel Melissa , Krüsi Andrea , Shannon Kate 
Published: March 2019

Objective. To determine the impact of engagement with third parties (i.e., managers, receptionists, or owners of in-call venues; advertisers; security; spotters; and others) on sex workers’ occupational health access. Methods. We drew longitudinal data from An Evaluation of Sex Workers’ Health Access, a community-based cohort of more than 900 women sex workers. We used multivariable logistic regression and generalized estimating equations to (1) examine factors correlated with accessing third-party administrative or security services and (2) evaluate the impact of third-party services on access to mobile condom distribution and sex worker and community-led services (2010–2016). Finally, we evaluated changes in accessing third-party services pre–post end-demand criminalization (2010–2017). Results. Im/migrant sex workers (persons with any type of legal status who were born in another country; adjusted odds ratio [AOR] = 2.32; 95% confidence interval [CI] = 1.35, 3.98) had higher odds of accessing third-party services. In confounder models, third-party services were independently correlated with increased access to mobile condom distribution (AOR = 1.84; 95% CI = 1.47, 2.31) and sex worker and community-led services (AOR = 1.61; 95% CI = 1.15, 2.24). End-demand criminalization was linked to a decrease in access to third-party services (AOR = 0.79; 95% CI = 0.63, 0.99). Conclusions. This research suggests that access to administrative and security services from third parties increases sex workers’ occupational health and safety. Policy reforms to ensure sex workers’ labor rights, including access to hiring third parties, are recommended.
Rural–Urban Differences in the Decline of Adolescent Cigarette Smoking
Authors: Ziller Erika C. , Lenardson Jennifer Dunbar , Paluso Nathan C. , Talbot Jean A. , Daley Angela 
Published: March 2019

Objectives. To examine change over time in cigarette smoking among rural and urban adolescents and to test whether rates of change differ by rural versus urban residence. Methods. We used the 2008 through 2010 and 2014 through 2016 US National Survey of Drug Use and Health to estimate prevalence and adjusted odds of current cigarette smoking among rural and urban adolescents aged 12 to 17 years in each period. To test for rural–urban differences in the change between periods, we included an interaction between residence and time. Results. Between 2008 to 2010 and 2014 to 2016, cigarette smoking rates declined for rural and urban adolescents; however, rural reductions lagged behind urban reductions. Controlling for socioeconomic characteristics, rural versus urban odds of cigarette smoking did not differ in 2008 through 2010; however, in 2014 through 2016, rural youths had 50% higher odds of smoking than did their urban peers. Conclusions. Differential reductions in rural youth cigarette smoking have widened the rural–urban gap in current smoking rates for adolescents. Public Health Implications. To continue gains in adolescent cigarette abstinence and reduce rural–urban disparities, prevention efforts should target rural adolescents.
Pregnancy Outcomes in US Prisons, 2016–2017
Authors: Sufrin Carolyn , Beal Lauren , Clarke Jennifer , Jones Rachel , Mosher William D. 
Published: March 2019

Objectives. To collect national data on pregnancy frequencies and outcomes among women in US state and federal prisons. Methods. From 2016 to 2017, we prospectively collected 12 months of pregnancy statistics from a geographically diverse sample of 22 state prison systems and the Federal Bureau of Prisons. Prisons reported numbers of pregnant women, births, miscarriages, abortions, and other outcomes. Results. Overall, 1396 pregnant women were admitted to prisons; 3.8% of newly admitted women and 0.6% of all women were pregnant in December 2016. There were 753 live births (92% of outcomes), 46 miscarriages (6%), 11 abortions (1%), 4 stillbirths (0.5%), 3 newborn deaths, and no maternal deaths. Six percent of live births were preterm and 30% were cesarean deliveries. Distributions of outcomes varied by state. Conclusions. Our study showed that the majority of prison pregnancies ended in live births or miscarriages. Our findings can enable policymakers, researchers, and public health practitioners to optimize health outcomes for incarcerated pregnant women and their newborns, whose health has broad sociopolitical implications.
The State of the US Governmental Public Health Workforce, 2014–2017
Authors: Sellers Katie , Leider Jonathon P. , Gould Elizabeth , Castrucci Brian C. , Beck Angela , Bogaert Kyle , Coronado Fátima , Shah Gulzar , Yeager Valerie , Beitsch Leslie M. , Erwin Paul C. 
Published: March 2019

Public health workforce development efforts during the past 50 years have evolved from a focus on enumerating workers to comprehensive strategies that address workforce size and composition, training, recruitment and retention, effectiveness, and expected competencies in public health practice. We provide new perspectives on the public health workforce, using data from the Public Health Workforce Interests and Needs Survey, the largest nationally representative survey of the governmental public health workforce in the United States. Five major thematic areas are explored: workforce diversity in a changing demographic environment; challenges of an aging workforce, including impending retirements and the need for succession planning; workers’ salaries and challenges of recruiting new staff; the growth of undergraduate public health education and what this means for the future public health workforce; and workers’ awareness and perceptions of national trends in the field. We discussed implications for policy and practice.