bluuebunny/crossref_metadata_2025_split huggingface dataset:
STATEOF KIDNEYS VASCULAR ENDOTHELIUM AND SYSTEMIC ENDOTHELIUM DYSFUNCTION OF VESSELS IN PATIENTS WITH HENOCH-SCHÖNLEIN PURPURA
Authors: Syniachenko O.V. , Bevzenko T.B. , Diadyk O.O. , Iermolaieva M.V. , Iegudina Е.D. , Suiarko VI. 
Published: June 2018

Purpose – to assess the nature of the vascular endothelium dysfunction in henoch–schonlein purpura (HSP) with glomerulonephritis (GN), its pathogenetic importance, the degree of change arteriole endothelium and immune deposits in the glomerular endothelium cells of the kidneys, and their relationships.
Material and methods. The study included 82patients with HSP, among which in 21 cases of GN in vivo reserash of kidney tissue was accomplished, including the degree of immune complexes deposits in the endothelial cells were studied. Indicators of vascular endothelium function were compared with blood levels of immune-inflammatory proteins and the nature of the adsorption-rheological properties of serum. The state of changes in blood vessels of the kidneys and the immunoglobulin’s (Ig) A, G, Mlevel ofdeposits in the glomerular endothelium cells, C3- and Clq-components ofcomplement were assessed.
Results and discussion. HSP is accompanied by increase in blood the level of endothelin-1, thromboxane-A2 and cyclic guanosine monophosphate against a background of decrease the amount of prostacyclin and nitrite, which is related to the total level of disease activity and severity of kidney damage, with the parameters of fibrinogen, $2-microglobulin, IgA, IgG, IgM, rheumatoid factor and circulating immune complexes in blood, as well as surface tension, viscoelasticity modulus, surface and volumetrical viscosity of serum. The level of thromboxanemia determines the severity of vessels’elas- tofibrosis and the indices of cyclic guanosine monophosphate - the degree of proliferation of the arteriolar endothelium and the deposits of IgG in the glomerulus’endotheliocyte.
Conclusions. Expressed disturbances of vessels’ endothelium function peculiar to HSP, that is determined by the activity of the disease and the severity of GN, correlated with blood levels of immune-inflammatory proteins and the disorders of adsorption-rheological properties of serum, the affection of the endothelium of arterioles of the kidneys and increase in the deposition of immune complexes in the glomerulus’endotheliocytes.
COMPLEX RADIONUCLIDE EVALUATION OF STRUCTURAL AND FUNCTIONAL STATE OF THE SINGLE KIDNEY IN CHILDREN
Authors: Kundin V. 
Published: June 2018

Summary. Introduction. The aim of the work is the determination of functioning of the single kidney (SK) by
complex scintigraphic research with using nephrotrophic radiopharmaceuticals (NRP) of different mechanisms of elimination and the detection of its diagnostic significance.
Materials and methods. 90 children (range 5-16 years) with SK were examined: dynamic (DRSG) and static (SRSG) scintigraphy with angiography was made them. 150 scintigraphic examinations with different NRP were made: 99mTc-DTPA (diethyleneaminopentacetate) – 51, 99mTc – PP (pyrophosphate) – 40,99mTc – DMSA (dymethylenesuccinateacetate) – 34, 99mTc MAG3 (mer- captoacetyle-3-glycine) – 15, 99mTc-EC (ethylenedicysteine) – 10. Time options of renal blood flow and transport of NRP, SGF, ERP were determined. Control group consists of15 children.
Results.The main scintigraphic features ofSK are: presence of single kidney on scintigraphic image; slowdown of time options of renal haemodynamic, increasing of SGF and ERP of SK on 50-60 %; decreasing of standard parameters SGF and ERP on 40-50%. The slowdown of SK excretion ability is associated with retention NRP in parenchyma. Proportions of SK increase on 2-3 sm average, and size of scintigraphic picture – on 40%. The main type of renographic curve in children with SK is parenchymatose, and it is found in 50% ofpatients. The accumulation and distribution of NRP in SK in 73,3 % is quite uniform.
Conclisions. Thus, SK in children functions in strain way of all compensation mechanisms that provide blood purification from products of vital functions, which shows the slowdown of main options of the SKfunctioning.
ASSOCIATION OF ADSORPTION-RHEOLOGICAL PROPERTIES OF URINE IN GLOMERULONEPHRITIS WITH MORPHOLOGICAL CHANGES OF RENAL STRUCTURES IN PATIENTS WITH HEMORRHAGIC VASCULITIS
Authors: Syniachenko O. , Bevzenko T. , Syniachenko P. , Diadyk O. 
Published: June 2018

The aim of the work: to assess adsorption-rheological state of urine in patients with hemorrhagic vasculitis (HV) with glomerulonephritis (GN), comparing the indicators with the nature of the morphological changes of the glomeruli, tubules, interstitium and vessels of the kidneys.
Materials and methods. Microscopy of nephrobiopsy specimens was performed in 21 patients with HVwith GN, urinary syndrome and preserved renal function. Using computer tensiometers “MPT2-Lauda”, “ADSA-Toronto” and “PAT2-Sinterface” indicators of surface viscosity, surface elasticity, module of viscoelasticity, relaxation time (RT), dynamic surface tension (ST) of urine, inclination angle and phasic angle (FA) of tensiongrams were studied.
Results and discussion. GN in HV is accompanied by a significant increase in (11%) the equilibrium ST of urine in 57% of patients on the background of decrease (21%) of FA. Adsorption-rheological condition of urine depends on the sex ofpatients and blood pressure level, the relative density of this biological fluid (RT, FA), its content ofprotein and non-protein nitrogen products, glomerular filtration rate and morphological class of GN (ST). The severity of the some renal structures lesion, the level of immune deposits in the mesangium, endothelium of glomerular capillary and podocytes, the degree of plasmatic impregnation arterioles and vascular endothelial proliferation significantly affect the integrated physical and chemical properties of urine. Prognostic significance in relation to the severity of morphological changes in the kidneys has an indicator of ST.
Conclusions. Assessment of adsorption- rheological properties of urine is a diagnostic method of GN in HV, and variations of such physic-chemical parameters are determined by morphological class and the clinical course of renal pathology, correlated with the severity of glomerular, tubular, interstitium and vessels lesion
THE RENAL LESION IN SYSTEMIC VASCULITIS
Authors: Syniachenko O.V. , Bevzenko T.B. , Iermolaieva M.V. , Diadyk O.O. 
Published: June 2018

The aim and the objectives: to investigate the frequency and the character of renal lesion in systemic vasculitis, as well as aspects of the pathogenesis of nephropathy in this category of patients.
Material and methods: investigate 525 patients, including 193 - with vasculitis Shenlayna-Henoch, 116- with microscopic polyangiitis, 93 - with cryoglobulinemic vasculitis, 39 - with polyarteritis nodosa, 29 - with aortoarteritis Takayasu, 28 - withWegener’s granulomatosis and 27 - with eosinophilic vasculitis Churg-Strauss.
Results: the renal lesion is observed in 52-68% cases of vasculitis depends on the age and the sex of the patients, the duration of the disease, the degree of activity of the pathological process, alteration in the heart and lungs, integrated severity extrarenal signs of the disease, at that, the rate ofprogression of nephropathy associated with the character of the disorders of the immune system, the rheological properties of blood and endothelial vessels’function.
Conclusions: kidney disease is one of the leading signs of systemic vasculitis and observed in most patients, it is determine the course of the disease.
HLA-PHENOTYPE IN PATIENTS WITH GLOMERULONEPHRITIS WITH VARIOUS MORPHOLOGIC FORMS AND NEPHROTIC SYNDROM
Authors: Kolesnyk M. , Driyanska V. , Drannik G. , Petrina O. , Velychko M. , Nepomnyaschiy V. , Liksunova L. , Gaysenyuk F. 
Published: June 2018

In the work was determined the HLA-phenotype specificities in patients with different morphologic forms of chronic glomerulonephritis and nephrotic syndrome (CGN, NS) to define the additional predictors of a disease course.
Materials and methods. There was studied the HLA-antigens distribution in the 264 CGN, NS patients and 350 healthy donors by typing the lymphocytes with the aid ofstandard microlymphocytotoxic test (Terasaki’s test). The diagnosis was confirmed morphologically using the thin needle nephrobiopsy.
Results. It is advisable to associate CGN, NS (RR > 2) with antigens HLA- A23, 24, 28; B8, 38, 41, 44 in patients; the causal role (a > 0.1) was determined for A24, 28; B8. In proliferative GN was additionally revealed the etiologic role of B27 known as antigen associated with risk ofautoimmune diseases. In patients with various morphologic forms is advisable the association of some antigens with development of chronic renal failure (CRF) – A30, B41 in FSGS, A10 – MGN; and also hormone resistance (HR) – A19+31+32 in FSGS, B8 – MGN and MC.
Conclusion. The revealed reliable associations ofHLA types both with CGN, NS and its separate morphologic forms with the risk of CRF and/or HR allow take into consideration the availability ofsuch antigens in phenotype ofpatients with confirmed by biopsy diagnosis as the additional diagnostic and prognostic markers.
CORRECTION OF RESISTANT ARTERIAL HYPERTENSION IN PATIENTS WITH CHRONICKIDNEYDISEASE STAGE I–III
Authors: Loboda O. M. 
Published: June 2018

Aim. The aim was to investigate the use of the I1–imidazoline receptor agonist moxonidine as an ‘add–on’ agent and determine its effect on heart rate variability in patients with CKD st. I–III and resistant hypertension.
Methods. We investigated the safety and efficacy of moxonidine (200–600 mg) in a group of 35patients with CKD st. I–III whose had prior treatment with three or more antihypertensive medications, although without adequate control [systolic blood pressure (SBP) 145–165 mm Hg and/or diastolic BP (DBP) 95–100 mm Hg]. BP was measured according to internationally accepted guidelines before and after 3 month of treatment with moxonidine used as an ‘add–on’ agent in the patients with CKD st. I–III and resistant hypertension. Age ofpatients was 53±5,8 years. Glomerular filtration rate (GFR) before treatment was 68,7±23,0 mL/min/1,73m 2. Before and 3 months after treatment, we determined improvement in the time–frequency analysis of heart rate variability.
Results. Following treatment with moxonidine, the SBP significant fell from 153.6±8.1 to 130.7±4.6 mmHg (P< 0.001). The DBP also showed a significant reduction from 96.7±2,4 to 80.9±2,6 mmHg (P< 0.001). Reduction
of SBP pressure was 22.9±7.9 mm Hg and reduction of DBP was 15.9±3.1 mm Hg. 29patients (83%) achieved the goal blood pressure – 130/80 mm Hg and less. 5 patients (14%) were not achieve goal blood pressure, but blood pressure lowered <140/90 mm Hg. In 1 patient (3%) blood pressure decreased from 160/100 mm Hg to 145/90 mm Hg. The majority of patients (28 – 80%)
STATE OF URINARY TRACTS’IMMUNITYINPATIENTS WITH ACUTE PYELONEPHRITIS AND CYSTITIS
Authors: Rudenko A. , Kornilina O. , Mitchenko N. , Pasechnikov S. 
Published: June 2018

Materials and methods. 64 patients with acute pyelonephritis (AP) and 15 healthy women were examined. in urine were determined indices which characterized a state of urinary tracts’ immunity. The analysis of immunological data of urine was carry out in patients with AP (first detected) and by exacerbation chronic pyelonephritis with concomitant cystitis (acute or chronic) or without him.
Results. in urine of AP patients were marked useful increase of levels of many immunological indices – complement’s C3–component, lactoferrin, lisozym, myeloperoxidasa, immunoglobulins A, М, G, secretory igA (sigA), secretory component (SC) and cytokine’s disbalans TNF– a and iL–10 with predomination of proinflammatory cytokines.
Conclusions. in urine of patients with AP and cystitis observed the greatest elevation of above–mentioned indices levels except igA, sigA and SC level. The reliable differences between the groups of patients with AP with concomitant acute or chronic cystitis don’t showed save the igM level which reliable rised in patients with acute cystitis.
INDICATORS OF OXIDATIVE STRESS AND RESISTANCE OF ERYTHROCYTES IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE VD DEPENDING ON MODALITY OF RENAL REPLACEMENT THERAPY
Authors: Kolesnyk M. , Korol L. , Migal L. , Burdeyna O. , Novakivskyy V. 
Published: June 2018

The object was to study the effect of oxidative factors and methods of renal replacement therapy (RRT) on indices of oxidative stress (OS) and resistance cells in blood in patients with chronic kidney disease stage V(CKD VD) and anemic syndrome.
Material and methods. The study involved 47 patients with CKD VD: 14patients were treated by hemodiafiltration (HDF), 14 patients by hemodialysis (HD) and 19 patients by peritoneal dialysis (PD). The severity ofanemia was assessed according to the KDIGO (2012) criteria. The control group consisted of30 healthy people of the same age and sex. Along with the standard diagnostic methods, we defined the content of malonic dialdehyde in serum (MDAs) and in erythrocytes (MDAe), the content of ceruloplasmin (CPs), transferrin (TRs) and SH - groups in the blood serum, the index of the OS (IOS), catalase activity in serum (CTs), glucose - 6 - phosphate dehydrogenase (G - 6 - PDHe) and total peroxidase activity (TPA) in erythrocyte, osmotic (OR) and peroxide resistance (PR) of red blood cells and erythrocyte membrane permeability (EMP). Statistical analysis was performed using the programs Microsoft Excel 5,0 and MedStat.
Results. It has been stated that in the CKD VD patients agains the rates in control group the MDAs content increased by 3.3 times and MDAe - 1.2 times, TRs content reduced by 34%, SH - groups - by 31%, TPAe - by 41% and G - 6 - FDGe - by 58%, marcers of OR by 30%, PR - by 60%; 4.6 times increased CTs activity and OSI; 2 times grew peroxide hemolysis (PH) and 1.3 times - EMP. The analysis (depending on the RRT modality) showed that the patients treated by HDF had typical MDAs increase by 3.9 times on a background of CPs by 24%o, TRs - 33%, SH - groups - 25%, TPAe - 51%, G6 - PDHe - 42%; the increase in serum OSI - 5.4 times and 2.6 times in erythrocytes, PR - by 3.6 times and CTs activity by 3,5 times; HD group were characterized by the highest value of MDAe, OSI, PH and CTs, along with more expressed decrease of indices TRs, SH - groups, TPA and G - 6 - FDHe activity compared with rates in patients with HDF. The patients treated with PD had the lowest content of MDAs and the highest values on the background ofTPAe, the significant increase of CPs by 1.7 times and lowest TRs and G - 6 - PDHe. The patients with PD showed twice lower OS activity by OSI.
Conclusion.Thus, in patients with CKD VD, who had HD, HDF or PD an anemic syndrome was associated with high OS activity and the increased degree of hemolysis. These changes are stipulated by RRT methods: for patients receiving HDF were typical the lowest rates of hemolysis and the highest degree of protection for erythrocytes, and for patients treated with HD - the highest OS.
INTERLEUKIN 10, BODY MASS INDEX AND SERUM ALBUMIN IN CHRONIC KIDNEY DISEASE STAGE 5D PATIENTS
Authors: Dudar I. , Drijanska V. , Grigorjeva E. , Gonchar J. , Krasjuk E. 
Published: June 2018

IL-10 - one of the central factors in the altered cytokine network of uremia, may play important role in the development of T-helper imbalance, CVD and wasting in dialysis patients.
Aim: to evaluate level of ІL-10 in CKD stage 5D patients depending on the body mass index and serum albumin.
Methods: Thirty-nine HD patients were included (male/female 20/19, age 21- 53 years, mean dialysis treatment time 4.2 ± 1.21 years). Blood tests were taken before a midweek dialysis session. Serum IL-10, serum albumin and BMI were measured.
Results: HD patients had higher serum IL-10 than healthy donors (79.9 ± 7.3 vs. 18.8 ± 1.3 pg/ml, p < 0.001). Patients with low BMI had lower serum IL-10 than patients with normal BMI and large BMI – 31.0 ± 6.3 pg/ml; 76.7 ± 10.1 pg/ml; 117.7 ± 6.2 pg/ml, respectively (p < 0.001). Higher IL-10 was associated with increased serum albumin.
Conclusion: Compensative increase of anti-inflammatory cytokine IL-10 in serum is typical in HD patients. Patients with nutrition deficit are characterized by lower serum IL-10.
USING OF LONG ACTION ERYTHROPOES STIMULATED AGENTS FOR TREATMENT OF ANEMIA IN PATIENTS WITH CHRONIC KIDNEY DISEASES V D ST
Authors: Kolesnyk M. , Kulyzkyp M. , Busygina Y. , Bilenko A. , Novakivskyy V. 
Published: June 2018

the article describes approaches to cost optimization of anemia treatment in CKD–VDst. patients by comparison of costs in phase correction and support treatment with long action ESA in patients on HD and HDF.
Aims. To reveal the influence of HD and HDF to summary dozes of ESA in anemia treatment, to reveal the influence of different long action ESA to hemoglobin variability and find connection between HD, HDF and ESA type to cost of ESA using.
Materials and methods. There were 14 patients on HD and 14 on HDF. All patients were treated with dialysis 3 time per week, session duration was 4,5–5 hours. eKt/У were 1,39±0,06 in HDF group and 1,29±0,07 in HD group. Mean hemoglobin was 98,3±2,46 g/l in HDF group and 92,76±2,46 g/l in HD group. In correction phase we used pegylated erythropoietin–p in both groups before achievement target hemoglobin 110 g/l, then was support phase ofanemia treatment during 6 months with hemoglobin target 100g/l to 120 g/l. Next 6 months patients were switched to darbepoetin alfa.
Results. It is investigated optimization of anemia correction with long action ESP in patients on HD and HDF. It is revealed a tendency to decrease treatment cost with pegylated erythropoietin–p compared to darbepoetin alfa (1965,13±250,69 vs 2117,39±147,59 Gr/mth) and HDF group compared HD group with pegylated erythropoietin–p (1983,9±345,9 vs 1950,69±367,1 Gr/mth). Treatment with darbepoetin alfa associated with higher hemoglobin variability compared with pegylated erythropoietin–p.
Conclusion. The result of our investigation lead to prove some hope to optimization of anemia treatment in patients with CKD Vst. On hemodialysis, but to have statistically reliability we need lager patients groups.
DYSLIPIDAEMIA IN CHILDREN ON DIALYSIS AND AFTER KIDNEY TRANSPLANTATION
Authors: Baiko S. V. 
Published: June 2018

Cardiovascular complications are the main problems associated with end stage renal disease (ESRD) in adult, which began renal replacement therapy (RRT) in childhood. One of the factors contributing to this can be an imbalance of blood lipids.
Aim of the study was to evaluate changes in the lipid profile in children with ESRD, depending on the RRT method and age, and also after kidney transplantation depending on the glomerular filtration rate.
Materials and methods. In 91 children with ESRD at the age of 2–17 years who received peritoneal dialysis (PD) or hemodialysis (HD), or after kidney transplantation (Tx), total cholesterol (CH), triglycerides (TG), lipoproteins high density (HDL) ) were measured in 663 samples of blood and calculated fraction of non–HDL (CH – HDL). Dyslipidemia was defined as TG>1,13 mmol/1 (0–9years) and >1,47mmol/l (10–17years), CH> 5,18mmol/l, non–HDL >3,7mmol/l, HDL <1.0 mmol/l.
Results. The prevalence of dyslipidemia in children was 90,4% on PD, 65,2% on HD and 32,6% after Tx, mainly due to hypertriglyceridemia in 80,8% on PD, 65,2% on HD and 20,8% after Tx. The levels ofTG and non–HDL were also significantly higher in PD and HD patients than after Tx. Children of the younger age group (2–5 years) on PD had the worst lipid profile. After kidney transplantation a significant reduction of TG and cholesterol was detected in PD patients and only TG in HD patients. Reduction of the glomerular filtration rate in children after kidney transplantation is accompanied by an increase in TG levels.
Conclusion. Dyslipidemia is widespread in children on RRT. Preemptive kidney transplantation can prevent the development of severe lipid imbalance which persists of dialysis treatment.
Pengaruh Kualitas Produk, Harga, Promosi dan Tempat Pendistibusian Terhadap Keputusan Pembelian Sepeda Motor Yamaha Pada Perusahaan Tjahaja Baru Bukittinggi
Authors: Syaleh Hariman 
Published: June 2018

Yamaha as a growing automotive company today realizes the importance of strategy in winning market competition.This research aims to determine the effect of product quality, price, promotion and istribution place on purchasing decision of yamaha motorcycle in Tjahaja Baru Bukittinggi. Sample of this research are 96 customers who buy Yamaha motorcycle in company Tjahaja Baru Bukittinggi which is chosen by accidental sampling technique.Variablesused in this research are of Product X1, Price X2, Promotion X3 and Distribution X4 as independent variable and purchase decision as dependent variable. Data analysis technique used is multiple linear regression.The result of this study indicate that the product, promotion and distribution have a positive and significant effect on purchasing decision of Yamaha motor in company Tjahaja Baru Bukittinggi, while price has a positive but not significant effect on purchasing decision of Yamaha motor in company New Tjahaja Bukittinggi.

Keywords: Products, Price, Promotion, Distribution, Buying decision
Pengaruh Motivasi dan Gaya Kepemimpinan terhadap Produktivitas Kerja Karyawan pada Perusahaan Cahaya Berlian
Authors: Hendriati Yossi 
Published: June 2018

Low labor productivity of employees in an organization or company is a symptom or problem that can cause the company is less stable because it can cause the unfulfillment of achievement of corporate goals. This study aims to analyze the influence of motivation and leadership style on employee productivity in company Cahaya Berlian. The population in this research is company Cahaya Berlian employees and the sample used is representative of the population with the number of 100 respondents by using nonprobability sampling technique in data collection. The results showed that the motivation and leadership style partially has significant effect on the performance of employees of company Cahaya Berlian.
Key words:Motivation, Leadership style, Employee Productivity.
Pengaruh Ukuran Perusahaan, ROA, DAR, Dan Reputasi Auditor terhadap Audit Delay
Authors: Irman Mimelientesa 
Published: June 2018

This study aims to analyze the factors that affect audit delay on manufacturing companies listed in Indonesia Stock Exchange. This test uses multiple linear regression model. Sample of this study are 20 companies in manufacturing sector. Observation period is 6 years from 2010 to 2015. Independent variables in this study consisted of company size, profitability, solvency, and auditors reputation which tested its influence on audit delay as dependent variable. The results showed that company size, profitability, solvency, and auditors reputation significantly influence on audit delay of manufacturing companies listed in Indonesia Stock Exchange period 2010 until 2015
Keywords: Firm size, ROA, DAR, Reputation Auditor and Audit Delay