bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyrethroid neurotoxicity studies with bifenthrin indicate a mixed Type I/II mode of action
Authors: Gammon Derek W , Liu Zhiwei , Chandrasekaran Appavu , El‐Naggar Shaaban F , Kuryshev Yuri A , Jackson Sharon 
Published: December 2018

AbstractBACKGROUNDBifenthrin is usually considered a Type I pyrethroid, because it lacks an α‐CN group present in Type II pyrethroids, but some previous studies suggest a mixed Type I/II mode‐of‐action. Results are presented for bifenthrin in a rat developmental neurotoxicity (DNT) study along with effects on Na currents in human VGSC subtypes. Molecular modeling comparisons were also made for bifenthrin and other pyrethroids.RESULTSIn a rat DNT study, bifenthrin produced tremors and clonic convulsions in dams and pups and slightly reduced acoustic startle response amplitude, and increased Tmax, at PND20 in females. Similar blood levels of bifenthrin were measured in dams and pups at each dose level i.e. no concentration in pups. In human VGSC experiments, using the Nav1.8 subtype, bifenthrin's effects on inactivation were slight, as for Type II pyrethroids, but without large prolongation of the tail current (deactivation) seen with Type II. Molecular modeling of bifenthrin indicates that the o‐Me group may occupy a similar space to the α‐CN group of cypermethrin and fenpropathrin.CONCLUSIONIn a DNT study and on human Nav1.8 tail currents bifenthrin showed Type I and II effects, similar to some published studies. Overall, bifenthrin acts as a mixed Type I/II pyrethroid. © 2018 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Practical adaptive fractional‐order nonsingular terminal sliding mode control for a cable‐driven manipulator
Authors: Wang Yaoyao , Li Binbin , Yan Fei , Chen Bai 
Published: December 2018

SummaryFor the high precise tracking control purpose of a cable‐driven manipulator under lumped uncertainties, a novel adaptive fractional‐order nonsingular terminal sliding mode control scheme based on time delay estimation (TDE) is proposed and investigated in this paper. The proposed control scheme mainly has three elements, ie, a TDE element applied to properly compensate the lumped unknown dynamics of the system resulting in a fascinating model‐free feature; a fractional‐order nonsingular terminal sliding mode (FONTSM) surface element used to ensure high precision in the steady phase; and a combined reaching law with adaptive technique adopted to obtain fast convergence and high precision and chatter reduction under complex lumped disturbance. Stability of the closed‐loop control system is analyzed with the Lyapunov stability theory. Comparative simulations and experiments were performed to demonstrate the effectiveness of our proposed control scheme using 2‐DOF (degree of freedom) of a cable‐driven manipulator named Polaris‐I. Corresponding results show that our proposed method can ensure faster convergence, higher precision, and better robustness against complex lumped disturbance than the existing TDE‐based FONTSM and continuous FONTSM control schemes.
Survey on the run‐time systems of enterprise application integration platforms focusing on performance
Authors: Freire Daniela L. , Frantz Rafael Z. , Roos‐Frantz Fabricia , Sawicki Sandro 
Published: December 2018

SummaryCompanies are taking advantage of cloud computing to upgrade their business processes. Cloud computing requires interaction with many kinds of applications, so it is necessary to improve the performance of software tools that allow keeping information on all these applications consistent and synchronised. Integration platforms are specialised software tools that provide support to design, implement, run, and monitor integration solutions, which aim to orchestrate a set of applications so as to promote compatibility among their data or to develop new functionality on top of the current ones. The run‐time system is the part of the integration platform responsible for running the integration solutions, which makes its performance the uttermost important issue. The contribution of this article is two‐fold: a framework and an evaluation of integration platforms. The former is a framework composed of ten properties grouped into two dimensions to evaluate the run‐time systems focusing on performance. Using this framework as reference, the second contribution is an evaluation of nine open‐source integration platforms, which represent the state‐of‐the‐art, provide support to the integration patterns, and follow the pipes‐and‐filters architectural style. In addition, as a result of this work, we suggest open research directions that can be explored to improve the performance of the run‐time systems and at the same time may be useful to adapt them to the context of cloud computing.
Differential Marking of Embryos by Location and Date of Release Reveals Within‐River Natal Homing and Parental Influence on Progeny Return Timing in Sockeye Salmon
Authors: Barnett Heidy K. , Quinn Thomas P. , Fresh Kurt L. , Koehler Michele E. , Burton Karl D. , Bhuthimethee Mary , Peterson N. Phil 
Published: December 2018

AbstractThe tendencies of salmon and trout to spawn in proximity to their natal sites and follow the parental timing of breeding are fundamental to their population structure and also affect the performance of enhancement facilities. Specifically, an understanding of how parental spawning date and offspring release location affect the timing and place of breeding by returning adults is important for the evaluation of hatchery supplementation programs and their integration with sympatric naturally spawning populations. We collected Sockeye Salmon Oncorhynchus nerka carcasses in the Cedar River, Washington, over three spawning seasons to evaluate spawn timing and distribution. Thermal marks on the otoliths of hatchery‐origin carcasses allowed assignment of fish to parents that spawned in the early, middle, and late parts of the season and to fry release locations in the lower, middle, and upper parts of the river. The early portion of the spawning run was composed of a higher proportion of hatchery‐origin fish than was the case later in the season. Hatchery‐origin adults that were released early in the spring as fry (from early spawning parents) were recovered early in the season, and those released later in the spring as fry were recovered later in the season. The natural‐origin spawn timing most closely matched the spawn timing of middle and late hatchery fry release groups in all years. Our data also demonstrated a correspondence between hatchery fry release location and adult recovery location; fry released at river kilometer (rkm) 1.0 were recovered 7.0 km lower (median value) in the river than fry released at rkm 21.7 and were recovered 10.0 km lower than fry released at rkm 35.1. These data contribute to the substantial body of evidence that population characteristics of anadromous salmonids are sensitive to influence from fish culture practices—even under benign regimes—because of the strong connections between parental and progeny timing and the fine‐scale homing of salmon to release sites within a river.
Sources of Bighead Carp and Silver Carp Found in Chicago Urban Fishing Program Ponds
Authors: Love Seth A. , Lederman Nathan J. , Widloe Tristan , Whitledge Gregory W. 
Published: December 2018

AbstractPlanktivorous Bighead Carp Hypophthalmichthys nobilis and Silver Carp H. molitrix are two invasive species that pose a severe threat to native aquatic biota. Efforts have been made to inhibit Bighead Carp and Silver Carp expansion into the Great Lakes through hydrologically connected systems, but understanding their expansion to and from hydrologically disconnected systems could further reduce this risk. We assessed the origin of 23 Bighead Carp and 1 Silver Carp captured from Chicago Urban Fishing Program ponds using otolith chemistry. Otolith core δ18O and δ13C of captured Bighead Carp did not overlap with ranges of otolith δ18O and δ13C from Bighead Carp and Silver Carp from the Illinois River but was consistent with otolith δ18O and δ13C of Bighead Carp obtained from aquaculture facilities. Likewise, otolith core Sr:Ca of 19 captured Bighead Carp was higher than the range of otolith Sr:Ca from Illinois River Bighead Carp and Silver Carp. Due to inferred timing of introduction (likely age‐0 or age‐1 fish), these Bighead Carp may have been released incidentally via stocking sport fish shipments contaminated with the carp. Contrastingly, otolith chemistry results suggest that the captured Silver Carp originated from the Illinois River, although timing of introduction of this fish could not be inferred. Overall, our results indicate that nearly all fish analyzed did not originate from rivers within the Mississippi River basin and were instead likely introduced through stocking contaminated shipments of fish. Even though Chicago Urban Fishing Program ponds now pose a minimal threat for Bighead Carp and Silver Carp expansion into Lake Michigan, sustained urban pond monitoring and nonnative fish removal may limit or eliminate this alternative invasion pathway. Additionally, continued vigilance in understanding the origin of stocked fish and culture environment (e.g., polyculture) could decrease the likelihood of future invasive species introductions through contaminated sport fish stockings.
eScience development and experiences in The Netherlands
Authors: Hazeleger Wilco , Bakker Tom , van Nieuwpoort Rob 
Published: December 2018

Abstract
The Netherlands eScience Center is the national expertise center for the development and application of research software. Collaborating with researchers from all academic disciplines, it extends the breadth and depth of research opportunities by exploiting the latest insights from computer and data science, as well as making optimal use of hardware, software, and data infrastructures. It does so through problem-driven research projects where eScience research engineers, employed by the eScience Center, collaborate with researchers in all disciplines at Dutch academic institutions. Project software is generalized and made available for reuse for other disciplines and goals. The center has three main technological competences: efficient computing, optimized data handling, and data analytics. Furthermore, on the national level it coordinates and contributes to science policies on computing, data, and applications thereof. With its two main assets, a staff of highly educated and multi-disciplinary eScience Research Engineers and an open online directory of research software tools and knowledge, it successfully contributes to the Dutch scientific landscape and enhances and accelerates all research in The Netherlands and beyond.
The influence of parents and schools on developmental trajectories of antisocial behaviors in Caucasian and African American youths
Authors: Morrison Ryann A. , Martinez Jonathan I. , Hilton Emily C. , Li James J. 
Published: December 2018

AbstractAfrican American youths are overrepresented in the American juvenile justice system relative to Caucasians. Yet, research on antisocial behaviors (ASB) has focused on predominantly Caucasian populations. Furthermore, relatively little is known about how environmental factors, such as supportive parenting (e.g., how close adolescents feel to their parent) and school connectedness (e.g., how supported adolescents feel at school), affect trajectories of ASB in Caucasians versus African Americans. This study mapped developmental trajectories of ASB in Caucasians (n= 10,764) and African Americans (n= 4,091) separately, using four waves of data from the National Longitudinal Study of Adolescent to Adult Health. We then examined supportive parenting and school connectedness on the trajectories of ASB. Four trajectories of ASB were identified for both Caucasians and African Americans: negligible, adolescence-peaked, low-persistence, and high-persistence ASB, although prevalence rates differed by racial-ethnic status. Supportive parenting reduced the risk of membership into the adolescence-peaked trajectory for both Caucasians and African Americans. However, school connectedness was less protective for African Americans than for Caucasians because it only predicted a lower risk of adolescence-peaked membership for African Americans. Findings may reflect the complex social dynamics between race and schools in the development of ASB.
Immune checkpoint inhibitors: recent progress and potential biomarkers
Authors: Darvin Pramod , Toor Salman M. , Sasidharan Nair Varun , Elkord Eyad 
Published: December 2018

AbstractCancer growth and progression are associated with immune suppression. Cancer cells have the ability to activate different immune checkpoint pathways that harbor immunosuppressive functions. Monoclonal antibodies that target immune checkpoints provided an immense breakthrough in cancer therapeutics. Among the immune checkpoint inhibitors, PD-1/PD-L1 and CTLA-4 inhibitors showed promising therapeutic outcomes, and some have been approved for certain cancer treatments, while others are under clinical trials. Recent reports have shown that patients with various malignancies benefit from immune checkpoint inhibitor treatment. However, mainstream initiation of immune checkpoint therapy to treat cancers is obstructed by the low response rate and immune-related adverse events in some cancer patients. This has given rise to the need for developing sets of biomarkers that predict the response to immune checkpoint blockade and immune-related adverse events. In this review, we discuss different predictive biomarkers for anti-PD-1/PD-L1 and anti-CTLA-4 inhibitors, including immune cells, PD-L1 overexpression, neoantigens, and genetic and epigenetic signatures. Potential approaches for further developing highly reliable predictive biomarkers should facilitate patient selection for and decision-making related to immune checkpoint inhibitor-based therapies.
Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery
Authors: Kos Mark Z. , Duan Jubao , Sanders Alan R. , Blondell Lucy , Drigalenko Eugene I. , Carless Melanie A. , Gejman Pablo V. , Göring Harald H. H. ,   MGS, Gejman P. V. , Sanders A. R. , Duan J. , Levinson D. F. , Shi J. , Buccola N. G. , Mowry B. J. , Freedman R. , Olincy A. , Amin F. , Black D. W. , Silverman J. M. , Byerley W. F. , Cloninger C. R. , Svrakic D. M. 
Published: December 2018

AbstractThe dopaminergic hypothesis of schizophrenia (SZ) postulates that positive symptoms of SZ, in particular psychosis, are due to disturbed neurotransmission via the dopamine (DA) receptor D2 (DRD2). However, DA is a reactive molecule that yields various oxidative species, and thus has important non-receptor-mediated effects, with empirical evidence of cellular toxicity and neurodegeneration. Here we examine non-receptor-mediated effects of DA on gene co-expression networks and its potential role in SZ pathology. Transcriptomic profiles were measured by RNA-seq in B-cell transformed lymphoblastoid cell lines from 514 SZ cases and 690 controls, both before and after exposure to DA ex vivo (100 μM). Gene co-expression modules were identified using Weighted Gene Co-expression Network Analysis for both baseline and DA-stimulated conditions, with each module characterized for biological function and tested for association with SZ status and SNPs from a genome-wide panel. We identified seven co-expression modules under baseline, of which six were preserved in DA-stimulated data. One module shows significantly increased association with SZ after DA perturbation (baseline: P = 0.023; DA-stimulated: P = 7.8 × 10-5; ΔAIC = −10.5) and is highly enriched for genes related to ribosomal proteins and translation (FDR = 4 × 10−141), mitochondrial oxidative phosphorylation, and neurodegeneration. SNP association testing revealed tentative QTLs underlying module co-expression, notably at FASTKD2 (top P = 2.8 × 10−6), a gene involved in mitochondrial translation. These results substantiate the role of translational machinery in SZ pathogenesis, providing insights into a possible dopaminergic mechanism disrupting mitochondrial function, and demonstrates the utility of disease-relevant functional perturbation in the study of complex genetic etiologies.
Integrin CD11b activation drives anti-tumor innate immunity
Authors: Schmid Michael C. , Khan Samia Q. , Kaneda Megan M. , Pathria Paulina , Shepard Ryan , Louis Tiani L. , Anand Sudarshan , Woo Gyunghwi , Leem Chris , Faridi M. Hafeez , Geraghty Terese , Rajagopalan Anugraha , Gupta Seema , Ahmed Mansoor , Vazquez-Padron Roberto I. , Cheresh David A. , Gupta Vineet , Varner Judith A. 
Published: December 2018

AbstractMyeloid cells are recruited to damaged tissues where they can resolve infections and tumor growth or stimulate wound healing and tumor progression. Recruitment of these cells is regulated by integrins, a family of adhesion receptors that includes integrin CD11b. Here we report that, unexpectedly, integrin CD11b does not regulate myeloid cell recruitment to tumors but instead controls myeloid cell polarization and tumor growth. CD11b activation promotes pro-inflammatory macrophage polarization by stimulating expression of microRNALet7a. In contrast, inhibition of CD11b preventsLet7aexpression and induces cMyc expression, leading to immune suppressive macrophage polarization, vascular maturation, and accelerated tumor growth. Pharmacological activation of CD11b with a small molecule agonist, Leukadherin 1 (LA1), promotes pro-inflammatory macrophage polarization and suppresses tumor growth in animal models of murine and human cancer. These studies identify CD11b as negative regulator of immune suppression and a target for cancer immune therapy.
Ultrastrong nanocrystalline steel with exceptional thermal stability and radiation tolerance
Authors: Du Congcong , Jin Shenbao , Fang Yuan , Li Jin , Hu Shenyang , Yang Tingting , Zhang Ying , Huang Jianyu , Sha Gang , Wang Yugang , Shang Zhongxia , Zhang Xinghang , Sun Baoru , Xin Shengwei , Shen Tongde 
Published: December 2018

AbstractNanocrystalline (NC) metals are stronger and more radiation-tolerant than their coarse-grained (CG) counterparts, but they often suffer from poor thermal stability as nanograins coarsen significantly when heated to 0.3 to 0.5 of their melting temperature (Tm). Here, we report an NC austenitic stainless steel (NC-SS) containing 1 at% lanthanum with an average grain size of 45 nm and an ultrahigh yield strength of ~2.5 GPa that exhibits exceptional thermal stability up to 1000 °C (0.75 Tm). In-situ irradiation to 40 dpa at 450 °C and ex-situ irradiation to 108 dpa at 600 °C produce neither significant grain growth nor void swelling, in contrast to significant void swelling of CG-SS at similar doses. This thermal stability is due to segregation of elemental lanthanum and (La, O, Si)-rich nanoprecipitates at grain boundaries. Microstructure dependent cluster dynamics show grain boundary sinks effectively reduce steady-state vacancy concentrations to suppress void swelling upon irradiation.
Visual capture of gait during redirected walking
Authors: Rothacher Yannick , Nguyen Anh , Lenggenhager Bigna , Kunz Andreas , Brugger Peter 
Published: December 2018

AbstractRedirected walking allows users of virtual reality applications to explore virtual environments larger than the available physical space. This is achieved by manipulating users’ walking trajectories through visual rotation of the virtual surroundings, without users noticing this manipulation. Apart from its applied relevance, redirected walking is an attractive paradigm to investigate human perception and locomotion. An important yet unsolved question concerns individual differences in the ability to detect redirection. Addressing this question, we administered several perceptual-cognitive tasks to healthy participants, whose thresholds of detecting redirection in a virtual environment were also determined. We report relations between individual thresholds and measures of multisensory weighting (visually-assisted postural stability (Romberg quotient), subjective visual vertical (rod-and-frame test) and illusory self-motion (vection)). The performance in the rod-and-frame test, a classical measure of visual dependency regarding postural information, showed the strongest relation to redirection detection thresholds: The higher the visual dependency, the higher the detection threshold. This supports the interpretation of users’ neglect of redirection manipulations as a “visual capture of gait”. We discuss how future interdisciplinary studies, merging the fields of virtual reality and psychology, may help improving virtual reality applications and simultaneously deepen our understanding of how humans process multisensory conflicts during locomotion.
Vinculin and the mechanical response of adherent fibroblasts to matrix deformation
Authors: Rosowski Kathryn A. , Boltyanskiy Rostislav , Xiang Yingjie , Van den Dries Koen , Schwartz Martin A. , Dufresne Eric R. 
Published: December 2018

AbstractCells respond to the mechanics of their environment. Mechanical cues include extracellular matrix (ECM) stiffness and deformation, which are primarily sensed through integrin-mediated adhesions. We investigated the impact of ECM deformation on cellular forces, measuring the time-evolution of traction forces of isolated mouse fibroblasts in response to stretch and release. Stretch triggered a marked increase of traction stresses and apparent stiffness. Expression of the focal adhesion protein vinculin not only increased baseline traction forces, but also increased dissipation of mechanical energy, which was correlated with the cells’ failure to recover baseline traction forces after release of stretch.
Hybrid Hydrogel Composed of Polymeric Nanocapsules Co-Loading Lidocaine and Prilocaine for Topical Intraoral Anesthesia
Authors: Muniz Bruno Vilela , Baratelli Diego , Di Carla Stephany , Serpe Luciano , da Silva Camila Batista , Guilherme Viviane Aparecida , Ribeiro Lígia Nunes de Morais , Cereda Cintia Maria Saia , de Paula Eneida , Volpato Maria Cristina , Groppo Francisco Carlos , Fraceto Leonardo Fernandes , Franz-Montan Michelle 
Published: December 2018

AbstractThis study reports the development of nanostructured hydrogels for the sustained release of the eutectic mixture of lidocaine and prilocaine (both at 2.5%) for intraoral topical use. The local anesthetics, free or encapsulated in poly(ε-caprolactone) nanocapsules, were incorporated into CARBOPOL hydrogel. The nanoparticle suspensions were characterized in vitro in terms of particle size, polydispersity, and surface charge, using dynamic light scattering measurements. The nanoparticle concentrations were determined by nanoparticle tracking analysis. Evaluation was made of physicochemical stability, structural features, encapsulation efficiency, and in vitro release kinetics. The CARBOPOL hydrogels were submitted to rheological, accelerated stability, and in vitro release tests, as well as determination of mechanical and mucoadhesive properties, in vitro cytotoxicity towards FGH and HaCaT cells, and in vitro permeation across buccal and palatal mucosa. Anesthetic efficacy was evaluated using Wistar rats. Nanocapsules were successfully developed that presented desirable physicochemical properties and a sustained release profile. The hydrogel formulations were stable for up to 6 months under critical conditions and exhibited non-Newtonian pseudoplastic flows, satisfactory mucoadhesive strength, non-cytotoxicity, and slow permeation across oral mucosa. In vivo assays revealed higher anesthetic efficacy in tail-flick tests, compared to a commercially available product. In conclusion, the proposed hydrogel has potential for provision of effective and longer-lasting superficial anesthesia at oral mucosa during medical and dental procedures. These results open perspectives for future clinical trials.