bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application value of couch height-based positioning in postoperative adjuvant radiotherapy for breast cancer
Authors: Shang Zaichun , Chen Jian , Li Ming , Ge Binbin , Feng Jinjin , Jin Jianhua , Wu Jianting , Ji Hanzhen , Chu Kaiyue , Zhang Xinhua 
Published: December 2024

Abstract

The purpose of this study is to explore the application value of positioning based on the treatment couch height in radiotherapy for left-sided breast cancer. Sixty patients who had undergone radical mastectomy for left breast cancer were selected, with each patient undergoing positioning based on the treatment couch height (couch height group) and positioning based on the reference marking lines (reference line group), to obtain the corresponding positioning errors. Meanwhile, 20 of 60 patients were randomly selected, and the planning system was used to simulate the changes in radiation doses in planning target volume (PTV) and organs at risk (OAR) along with the changes in positioning errors in dorsal (increasing couch height) and ventral (decreasing couch height), respectively. Compared with the original plan, when the positioning error in the dorsal direction reached 3mm, Dmean, V30, and V20 in The ipsilateral lung were increased by 35.12%, 16.35%, and 10.6% respectively, and V50 in PTV was decreased by 0.99% (all p < 0.05); when the positioning error in the ventral direction reached 1.5 mm, V50, V48, and V45 were decreased by 2.07%, 0.58%, and 0.14% respectively. The homogeneity index (HI) was increased by 14.28% (all p < 0.05). There was a statistically significant difference in the positioning errors in the ventral-dorsal directions between the couch height group (0.16±0.14 cm) and reference line group (0.36±0.25 cm) (p < 0.05); the percentages of the absolute positioning errors within 1.5mm and 3mm were 52.4%, 88.7% respectively in the couch height group and 29.8%, 54.4% respectively in the reference line group, (all p < 0.05). Dorsal positioning errors greater than 3 mm significantly worsen the dose distribution for both the PTV and OAR, while positioning based on the treatment couch height keeps 88.7% of positioning errors within 3 mm; ventral positioning errors greater than 1.5 mm result in significant changes in the dose within the PTV. Compared to the reference line group, positioning based on the treatment couch height controls 52.4% of positioning errors within 1.5 mm. Therefore, couch height positioning demonstrates greater advantages in managing ventral-dorsal positioning errors. This study provides a reference for clinical positioning in postoperative adjuvant radiotherapy of breast cancer.
Keywords: Breast cancer radiotherapy, Positioning error, Treatment couch height, Dose distribution
KIFC1 is a potential therapeutic target and prognostic biomarker for renal papillary cell carcinoma
Authors: Chen Binghai , Zhang Wentao , He Jun , Zhang Wenzheng , Zou Yuanzhang 
Published: December 2024

Abstract

Kinesin family member C1 (KIFC1) is a negative end oriented motor protein involving in supernumerary centrosome clustering and has been revealed to function as a novel target and/or prognostic indicator for multiple tumor types. However, the clinical significance of KIFC1 in renal papillary cell carcinoma (KIRP) has not been clearly established. In this study, we firstly analyzed the expression level of KIFC1 in KIRP and normal tissues by using the TCGA, GSE180777 and immunohistochemical staining assay. Subsequently, we compared the expression of KIFC1 in different clinicopathological features and assessed the role of KIFC1 in pRCC cell viability. Then, the clinical value of KIFC1 in diagnosis and prognosis and its relationship with immune cell infiltration in KIRP was analyzed. Lastly, the potential signaling pathway through which KIFC1 may contribute to the progression of KIRP was analyzed using GSEA. The results showed that the expression of KIFC1 was significantly increased in KIRP tissues compared with normal kidney tissues. Specially, the expression of KIFC1 in the patients with advanced stage was higher than those with early stage. The in vitro experiment result indicated that KIFC1 knockdown effectively decreased pRCC cell viability. ROC curve analysis suggested that the AUC value of KIFC1 in TCGA and GSE180777 dataset was 0.793 and 0.817, respectively. Survival analysis results showed that the higher KIFC1 expression, the lower overall survival, disease-specific survival, progression-free interval, and disease-free interval of patients. Immunoinfiltration analysis showed that KIFC1 expression was positively correlated with the infiltration abundance of B cells, CD4+T cells, CD8+T cells, neutrophils and dendritic cells, while negatively correlated with the infiltration abundance of macrophages. The results of GSEA analysis showed that KIFC1 was mainly involved in Oxidative phosphorylation, Collecting duct acid secretion, Valine, leucine and isoleucine degradation, Propanoate metabolism, Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism in KIRP. In conclusion, KIFC1 was highly expressed in KIRP, and its expression level was closely related to the progression, prognosis and immune cell infiltration, indicating KIFC1 could be used as a potential therapeutic target and prognostic marker for KIRP.
Survival of Total Knee Arthroplasty in Patients with Parkinson's Disease: A Registry Study
Authors: Panciera Alessandro , Martino Alberto Corrado Di , Bordini Barbara , Amabile Marina , D'Agostino Claudio , Digennaro Vitantonio , Faldini Cesare 
Published: December 2024

Abstract

Purpose
This study compared the demographics and outcomes of patients with Parkinson's disease (PD) undergoing total knee arthroplasty (TKA) to those without PD. Additionally, it aimed to assess the impact of implant design on TKA survival in PD patients.
Methods
Using data from the Emilia Romagna Registry of Orthopedic Prosthetic Implants, 551 TKA procedures in patients with PD were identified and compared to 52,022 TKAs in patients without PD. Kaplan-Meier survivorship analysis was used to compare implant survival, with revision surgery as the endpoint. Cox multivariate analysis was performed to assess the influence of age, gender, PD diagnosis, and implant design on implant failure.
Results
The average age of PD patients was 72.2 years, with 66.2% being female. Implant survival was significantly lower in the PD group compared to the control group (p<0.001). At 13 years, the survival rate was 88.8% in the PD group and 94.3% in the control group. PD patients had a 2.7 times higher risk of implant failure after adjusting for age and gender. Constrained implant designs were associated with a 1.7 times higher risk of failure compared to non-constrained designs in PD patients.
Conclusion
PD negatively affects implant survival in patients undergoing TKA. Careful consideration should be given to patient selection and implant design in this patient population.
Prognostic biomarker GOLM1 correlated with immune infiltrates in Endometrial cancer
Authors: Wang Hui , Luo Xiaodong , Hu Jianguo 
Published: December 2024

Abstract

Background
Endometrial cancer (UCEC) is a prevalent gynecological cancer that affects women’s reproductive organs. While studies indicate that GOLM1 may influence the immune response through the tumor microenvironment, its exact roles and mechanisms in UCEC are still not well understood. This study examines the varied expression levels of GOLM1 in UCEC and investigates the relationship between GOLM1 expression and the prognosis of patients with UCEC.
Methods
In this study, we analyzed data from the TCGA database. We utilized several bioinformatics methods, such as differential gene expression analysis, Kaplan-Meier survival analysis, gene set enrichment analysis, and immune cell infiltration analysis. These bioinformatics methods systematically integrate clinical data, gene expression, and immune information, offering a comprehensive view of the molecular mechanisms underlying UCEC.This study employed the software tools TCGA, GEPIA, TIMER, and MethSurv.
Results
GOLM1 mRNA levels were significantly elevated in UCEC tumor tissues. A strong association was found between GOLM1 expression and overall survival in UCEC patients. Enrichment analysis showed that GOLM1 is linked to several biological pathways, including dynein-bound intraflagellar transporters, fatty acid metabolism, and the transcriptional regulation of pluripotent stem cells. Based on these associations, GOLM1 likely plays an important role in the immune microenvironment of UCEC. Furthermore, GOLM1 expression may be influenced by DNA methylation.
Conclusions
GOLM1 is crucial for UCEC, as its levels significantly influence both the occurrence and progression of the disease. GOLM1 and its related genes are potential immunotherapeutic targets for UCEC. Additionally, DNA methylation may regulate the expression of GOLM1 in patients with UCEC.
Developing a prediction model for in-hospital mortality in sepsis patients with gastrointestinal bleeding using the MIMIC-IV database
Authors: Yao Fengwei , Luo Ji , Ming Yue , Zhao Zhiqiang , Wang Luhua , He Zhijun 
Published: December 2024

Abstract

Background: Sepsis associated with gastrointestinal hemorrhage is a critical condition in ICU patients, significantly impacting mortality rates. This study aimed to develop a predictive model for in-hospital death risk in sepsis patients with gastrointestinal bleeding, improving treatment strategies and resource allocation.
Methods: In a retrospective investigation of patients with sepsis and gastrointestinal bleeding, we gathered information from the MIMIC-IV database, including key demographics, comorbidities, laboratory indicators, and therapies.
The dataset was split 70:30 for model development and validation. The Least Absolute Shrinkage and Selection Operator (LASSO) approach was used to select features, and multivariate logistic regression was then used to create a prognostic model. A nomogram was created to visualize predictive outcomes. Model performance was evaluated using calibration curve, receiver operating characteristic (ROC) curve, clinical impact curve (CIC), and decision curve analysis (DCA).
Results: Nine significant predictors of in-hospital mortality were identified: APS III score, prothrombin time, body temperature, activated partial thromboplastin time, respiratory rate, vasopressor use, acute kidney injury, non-invasive ventilation, and malignancy. Area beneath the ROC curve for the training and testing groups
The values are 0.8266 (95% CI: 0.8018-0.8515) and 0.7961 (95% CI: 0.7577-0.8345), respectively. Our model outperformed the APS III score in terms of ROC curve discrimination and demonstrated greater net benefit on the DCA curve. The CIC showed strong concordance between predicted and actual in-hospital death rates when the predicted probability exceeded 70%.
Conclusion: We developed a robust predictive framework for assessing in-hospital death risk in sepsis patients with gastrointestinal hemorrhage. Early intervention based on identified risk factors could improve patient survival rates.
BACE2 is a prognostic biomarker and induced macrophage M2 polarization in Non-Small Cell Lung Cancer
Authors: Feng Yuanyuan , Zhou Xiaohan , Yang Kaifan , Zhu Ziyan , Liu Shuyi , Liu Jiabin , Zhou Jing , Deng Wenxiang , Xu Ziang , He Luhang , Song Miao , Wang Hongmei , Cai Longmei , Lin Yanling 
Published: December 2024

Abstract

BACE2 has gained attention for its upregulation in various human cancers, suggesting relevance in cancer biology. However, its specific role in tumor growth and the tumor immune microenvironment (TIME) remains underexplored. We conducted bioinformatics analyses using pan-cancer datasets to assess BACE2 expression patterns and its correlation with patient outcomes. Additionally, we investigated associations with immune-related genes and immune cell infiltrations in tumor microenvironments. A BACE2 knockdown lung cancer model was established to evaluate its impact on Sorafenib efficacy and PD-L1 inhibitor-induced antitumor immune responses. BACE2 was significantly upregulated in multiple cancers compared to normal tissues and associated with poorer patient outcomes. It played a critical role in modulating immune-related gene expression and promoting immune cell infiltrations within tumors. In vitro and in vivo experiments showed that BACE2 knockdown inhibited M2 macrophage polarization, suppressed lung tumor progression, and enhanced Sorafenib efficacy by increasing activated immune cell infiltrations. Similarly, BACE2 knockdown potentiated PD-L1 inhibitor-induced antitumor immune responses in lung cancer models. This study underscores BACE2's pivotal role in lung cancer tumorigenesis and its influence on the tumor immune microenvironment. Inhibiting BACE2 could enhance current treatment effectiveness in lung cancer therapy, offering promising avenues for improving patient outcomes.
Investigating the Combined Effect of Triglyceride-Glucose and Chinese visceral adiposity Index on Cardiovascular Diseases Risk in Middle-aged and Older Adults: A Cohort Study
Authors: Chen Xueyu , Qiao Junpeng , Zhu Nannan , Pang Jinhong , Fei Haicheng , Liu Zhang , Cheng Fang , Shi Fengxue , Jia Hongying 
Published: December 2024

Abstract

Background:
Cardiovascular diseases (CVDs) have become a significant public health issue, with a strong link to insulin resistance (IR). the triglyceride-glucose (TyG) index and Chinese visceral adiposity index (CVAI) are key indicators in the development of obesity and IR. However, few studies have examined the association between combined TyG and CVAI levels and CVDs.
Methods:
This cohort study base on the China Health and Retirement Longitudinal Study (CHARLS) from 2012 to 2020, ultimately including 6,871 and 3,913 participants to examine baseline and follow-up changes in TyG-CVAI and its association with CVDs, respectively. Participants were divided into four groups based on quartiles and into three classes based on changes in TyG-CVAI using K-means cluster analysis. Multivariable Cox regression analysis was conducted to assess the association between different TyG-CVAI groups and the risk of CVDs. The predictive effect of TyG-CVAI on CVDs was visualized using an ROC curve.
Results:
CVDs incidence was highest in the Q4 and Class 3 groups of TyG-CVAI, with rates of 33.0% and 36.74%, respectively. High baseline TyG-CVAI levels and persistently elevated TyG-CVAI levels are both significantly associated with an increased risk of CVDs incidence, with HRs and 95% CIs as follows:1.61(1.35–1.93),1.68(1.38–2.05), respectively. Persistently elevated TyG-CVAI levels are associated with a higher risk of CVDs incidence, with corresponding HRs and 95% CIs for TyG-BMI and TyG-WHtR at 1.49 (1.23–1.80) and 1.43 (1.17–1.75), respectively. TyG-CVAI demonstrates superior predictive performance for CVDs, CHD, and stroke, with AUCs of 0.594, 0.587, and 0.603, respectively.
Conclusion:
Monitoring long-term changes in TyG-CVAI may provide a novel scientific basis for early risk identification in CVD prevention among middle-aged and elderly individuals in China.
Diarrhea control using low-methoxyl pectin-containing enteral nutrition.
Authors: Tanaka Makoto , Akiyama Ryosuke , Yamaoka Ippei 
Published: December 2024

Abstract

Background
Diarrhea is the most common side effect of enteral nutrition and can lead to incontinence-associated dermatitis and malabsorption, indicating an unmet medical need for patients receiving enteral nutrition. Diarrhea related to enteral nutrition often occurs in conjunction with antibiotic use, highlighting the complexity of nutritional management and infection control. Here, we report an approach to address unmet medical needs by using low-methoxyl pectin-containing liquid diets, reconciling diarrhea control and antibiotic management.
Methods
Dysbiosis was induced in rats through a 4-week administration of an antibiotic cocktail added to drinking water. Different liquid diets, including fiber-free, low-methoxyl pectin, and partially hydrolyzed guar gum-containing formulas, were administered for 7 days using a gastric fistula. Fecal scoring and cecal histopathological examinations were conducted.
Results
The group administered a low-methoxyl pectin-containing liquid diet exhibited normal feces throughout the administration period that did not deteriorate with dysbiosis; additionally, mucosal atrophy was histopathologically suppressed. In contrast, fecal appearance deteriorated chronologically in the other liquid diet groups and worsened further with dysbiosis; frequent and strong villous atrophy was also observed.
Conclusions
A liquid diet containing low-methoxyl pectin controlled diarrhea in rats with antibiotic-treated dysbiosis. The mechanisms behind the improved fecal characteristics were attributed to the absorption of water and the inhibitory effect of dietary fiber on mucosal atrophy through stool formation. We hope to address these unmet medical needs through the use of low-methoxyl pectin in clinical settings in the future.
Cognitive on Prevention of Work-Related Musculoskeletal Disorders among Nurses in Shandong Province of China: A cross- sectional study
Authors: Yang Hailing , Cheng Yuepeng , Zhang Xu , Lin Hui , Basilio Pia Vanessa , S.Calibjo Mylene , Ma Aixia 
Published: December 2024

Abstract

Background
Work-related musculoskeletal disorders (WMSDs) have become major occupational health problems worldwide. Last year, 91.2% of nurses reported experiencing WMSDs in at least one region of their body. However, this issue has not received adequate attention among nurses. This study aims to determine the frequency of WMSDs and assess nurses' knowledge, attitudes, and practices regarding self-protective behaviors.
Methods
A cross-sectional study was conducted in March 2024 among full-time registered nurses from various departments in hospitals across Shandong Province, China. Demographic data, the Nordic Standardized Musculoskeletal Questionnaire, and questionnaires on knowledge, attitudes, and behaviors related to protection were used.
Results
A total of 697 nurses participated, 93.7% of whom were female and 87.7% who held a bachelor's degree or higher. The prevalence rates of WMSDs were 94.98% (historical), 93.11% (annual), and 87.37% (weekly), which are higher than those reported in relevant studies from Xinjiang. The top five affected body parts were the waist, neck, shoulders, back, and wrist. The WMSD prevalence was higher in women (96.02%) than in men (20.45%) and was highest among nurses aged ≥ 41 years and those with 16–20 years of experience (98.01% and 98.90%, respectively). Married nurses and those with a BMI ≥ 32.0 kg/m2 had prevalence rates of 95.85% and 100%, respectively. The factors significantly associated with WMSDs included sex, age, years of work, marital status, educational background, BMI, working hours, knowledge, and protective behaviors. The study revealed that 31.3% of nurses lacked knowledge about WMSDs, 65.1% reported no relevant training in their hospitals, and 90.7% were willing to participate in such training.
Conclusion
The prevalence of WMSDs among nurses in Shandong Province is high, with multiple body parts affected. Binary logistic regression analysis identified long periods of standing and lifting weights with one hand as risk factors. Strong protective behavioral abilities serve as a protective factor. This study highlights the need for increased attention and timely interventions from nursing managers.
Where there is no specialist – Improving Mental Health Literacy of Frontline Community Health Workers in a Rural District of Pakistan: The mPareshan Project
Authors: Akhtar Samina , Rabbani Fauziah , Nafis Javeria , Merali Zul 
Published: December 2024

Abstract

Background
In low- and middle-income countries (LMICs), four out of five people with mental illness do not receive specialized treatment. Utilizing non-specialist frontline workers to deliver basic mental health services at the community level therefore needs to be explored.
Aims
This study assessed improvement in knowledge and skills of frontline community workers in identifying symptoms of anxiety and depression, making appropriate referrals, and providing psychosocial counselling in a rural district of Pakistan.
Methods
Project mPareshan developed a training manual to improve mental health literacy of government’s Lady Health Workers (LHWs) and Lady Health Supervisors (LHSs). The content was adapted from WHO mhGAP 2.0 intervention guide to suit the local context. 72 LHSs and LHWs (36 each) from District Badin, Sindh, Pakistan received the training. A pre- and post-test was conducted to assess the change in knowledge and skills of participants using paired sample T-tests.
Results
The overall mean knowledge score of all participants increased significantly from 4.37 (SD = 1.45) before the mPareshan mental health literacy training, to 9.02 (SD = 1.48) after training (p < 0.01). The overall mean skills score for all participants was 8.07 (SD = 2.14) at pre-test and reached 9.84 (SD = 0.63) in post-test (p < 0.01). Mean scores of LHSs’ knowledge and skills were higher in most domains compared to LHWs.
Conclusions
This training in mental health has the potential to improve the overall knowledge and competencies of community health workers. Such endeavours can be upscaled so that frontline workers can serve as a useful workforce in the absence of specialist mental health services.
Evaluating Lead-Based vs. Lead-Free Perovskites for Environmentally Sustainable Indoor Photovoltaics
Authors: Clegg Charlotte , Mei Jianjun , Fuensanta Aitana Uclés , Ibn-Mohammed Taofeeq , Pecunia Vincenzo 
Published: December 2024

Abstract

Indoor photovoltaics (IPVs) based on halide perovskites (HPs) and derivatives (HPDs) hold great promise for powering the vast infrastructure of Internet-of-Things (IoT) smart devices. While lead-containing IPVs deliver cutting-edge performance, environmental concerns have spurred research into lead-free alternatives. However, the environmental sustainability of these IPV technologies remains underexplored, with the lead-based versus lead-free debate confined to elemental considerations, neglecting life-cycle impacts and IPV requirements. This study presents the first comparative life-cycle assessment (LCA) addressing the lead-based vs. lead-free HP/HPD IPV dilemma, examining the environmental sustainability of absorbers, precursors, functional layers, and fabrication steps. A modelling framework is introduced to evaluate the net environmental gains (NEGs) of IPVs compared to the conventional battery-centric approach for powering smart devices. Our findings challenge conventional assumptions that lead-free HP/HPD IPVs are inherently more eco-friendly than their lead-based counterparts. Moreover, we demonstrate that Pb- and Sn-based IPVs can achieve NEGs after just 3–4 weeks and 4–7 weeks, respectively, significantly outperforming mainstream IPVs. In contrast, the NEGs of Sb- and Bi-based IPVs align with mainstream IPVs, limiting their potential unless efficiencies increase to ~40%. Key strategies to enhance the eco-friendliness of HP/HPD IPVs and policy considerations on Pb-based IPVs for IoT sustainability are outlined.