bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood maltreatment and biomarkers for cardiometabolic disease in mid-adulthood in a prospective British birth cohort: associations and potential explanations
Authors: Li Leah , Pinto Pereira Snehal M , Power Christine 
Published: March 2019

ObjectivesResearch on associations between childhood maltreatment and adult cardiometabolic disease risk is sparse. We aimed to investigate associations between different forms of child maltreatment and mid-adult cardiometabolic markers and whether potential intermediaries could account for the associations observed.Setting1958 British birth cohort.ParticipantsApproximately 9000 cohort members with data on cardiometabolic markers.OutcomesAdult (45y) cardiometabolic markers (blood pressure, lipids and glycated haemoglobin [HbA1c]).ResultsSeventeen per cent of participants were identified as neglected; 6.1%, 1.6% and 10.0% were identified as experiencing physical, sexual and psychological abuse, respectively. Childhood neglect and physical abuse were associated with high body mass index (BMI) and large waist circumference when adjusting for early-life covariates. For neglect, the adjusted odds ratio (AOR) was 1.16 (95% CI: 1.02 to 1.32) and 1.15 (1.02 to 1.30) for general and central obesity, respectively, and for physical abuse, the respective AOR was 1.36 (1.13 to 1.64) and 1.38 (1.16 to 1.65). Neglect was also associated with raised triglycerides by 3.9 (0.3 to 7.5)% and HbA1cby 1.2 (0.4 to 2.0)%, and among females, lower high-density lipoprotein cholesterol (HDL-c) by 0.05 (0.01 to 0.08)mmol/L after adjustment. For physical abuse, the AOR was 1.25 (1.00 to 1.56) for high low-density lipoprotein cholesterol, HbA1cwas raised by 2.5 (0.7 to 4.3)% (in males) and HDL-c was lower by 0.06 (0.01 to 0.12)mmol/L (in females). Associations for sexual abuse were similar to those for physical abuse but 95% CIs were wide. For psychological abuse, the AOR for elevated triglycerides was 1.21 (1.02 to 1.44) and HDL-c was lower by 0.04 (0.01 to 0.07)mmol/L. Maltreatments were not associated with raised blood pressure. In analyses of potential intermediary factors, several associations attenuated after adjustment for adult lifestyles (mainly smoking and alcohol consumption rather than physical activity) and child-to-adult BMI.ConclusionsChildhood maltreatments, particularly neglect and physical abuse, were associated with greater adiposity and poorer lipid and HbA1cprofiles decades later in adulthood. Associations were modest but independent of early-life factors linked to these outcomes. Findings implicate adult lifestyles as an important intermediary between child maltreatment and outcomes.
Utilisation and perceptions towards smart device visual acuity assessment in Australia: a mixed methods approach
Authors: Keel Stuart , Scheetz Jane , Holloway Edith , Han Xiaotong , Yan William , Mueller Andreas , He Mingguang 
Published: March 2019

ObjectivesTo investigate mobile health product use in Australia and societal and clinician perceptions towards smartphone based visual acuity (VA) assessment tools.DesignQuantitative analysis of a cross-sectional survey delivered to the general public and thematic analysis of in-depth interviews of eye health clinicians.SettingOnline survey within Australia and face-to-face in-depth interviews of clinicians.Participants1016 adults were recruited via Survey Monkey Audience, social media (Facebook and Twitter), Rotary Australia and Lions Clubs Australia. Six clinicians were recruited from private and public settings in Melbourne, Australia.Primary and secondary outcome measuresThe study assessed socio-demographic characteristics, history of mobile health product use and perceived advantages and potential drawbacks of smartphone based VA assessment tools.ResultsA total of 14.4% of the study population had previously used a mobile-based health product. After adjusting for covariates, younger age (p=0.001), male gender (p=0.01) and higher income (>$45 000) were associated with increased likelihood of having used a mobile health product (p=0.005). Seventy-two per cent of participants would use an automated smartphone based VA assessment tool, provided that the accuracy was on par to that of human assessors. Convenience (37.3%) and cost-savings (15.5%) were ranked as the greatest perceived advantages. While test accuracy (50.6%), a lack of personal contact with healthcare providers (18.3%) and data security (11.9%) were the greatest concerns. Themes to emerge from clinician qualitative data included the potential benefits for identifying refractive error in patients, as well as the ability to self-monitor vision. Concerns were raised over the potential misuse of self-testing vision apps and the inability to detect pathology.ConclusionOur findings suggest that a substantial proportion of the Australian population do not use mobile health products. Furthermore, there remains notable concerns, including test accuracy and data privacy, with smartphone-based VA assessment tools by both clinicians and the public.
Modelling the effect of the introduction of antenatal screening for group BStreptococcus(GBS) carriage in the UK
Authors: Bevan David , White Alicia , Marshall John , Peckham Catherine 
Published: March 2019

ObjectivesTo estimate the potential impact of the addition of culture-based screening for group B streptococcus (GBS) carriage in pregnancy to a risk-based prevention policy in the UK. We aimed to establish agreement within a multidisciplinary group of key stakeholders on the model input parameters.DesignDeterministic model using a consensus approach for the selection of input parameters.Setting and participantsA theoretical annual cohort of 711 999 live births in the UK (excluding births by elective caesarean section).InterventionsCulture-based screening for GBS at 35–37 weeks of pregnancy added to the recommended risk-based prevention policy in place on the date of modelling.Outcome measuresOutcomes assessed included use of intrapartum antibiotic prophylaxis (IAP), early onset GBS (EOGBS), EOGBS mortality, severe EOGBS-related morbidity and maternal penicillin anaphylaxis.ResultsWith no prophylaxis strategy, the model estimated that there would be 421 cases of culture positive EOGBS in a year (0.59/1000 live births). In the risk-based prophylaxis scenario, 30 666 women were estimated to receive IAP and 70 cases of EOGBS were prevented. Addition of screening resulted in a further 96 260 women receiving IAP and the prevention of an additional 52 to 57 cases of EOGBS. This resulted in the prevention of three EOGBS deaths and four cases of severe disability. With screening, an additional 1675 to 1854 women receive IAP to prevent one EOGBS case and 24 065 to 32 087 receive IAP to prevent one EOGBS death.ConclusionsThe evidence base available for a broad range of model input parameters was limited, leading to uncertainty in the estimates produced by the model. Where data was limited, the model input parameters were agreed with the multidisciplinary stakeholder group, the first time this has been done to our knowledge. The main impact of screening is likely to be on the large group of low-risk women where the clinical impact of EOGBS tends to be less severe. This model suggests that the reduction in mortality and severe disability due to EOGBS with antenatal GBS screening is likely to be very limited, with a high rate of overdetection and overuse of antibiotics.
Effect of CPAP therapy on kidney function in patients with obstructive sleep apnoea and chronic kidney disease: a protocol for a randomised controlled clinical trial
Authors: Rimke Alex N , Ahmed Sofia B , Turin Tanvir C , Pendharkar Sachin R , Raneri Jill K , Lynch Emma J , Hanly Patrick J 
Published: March 2019

IntroductionObstructive sleep apnoea (OSA) is common in patients with chronic kidney disease (CKD) and may contribute to the progression of kidney disease either through direct effects of hypoxia on the kidney or indirectly through hypoxaemia-induced oxidative stress, endothelial dysfunction, inflammation, activation of the renin–angiotensin and sympathetic nervous systems, and hypertension. Treatment of OSA with continuous positive airway pressure (CPAP) improves many of these physiological abnormalities in patients with normal renal function, though to date there are no trials evaluating the effect of OSA treatment on kidney function in patients with CKD. The purpose of this study is to test the feasibility and efficacy of CPAP therapy in CKD patients with OSA.Methods and analysisThe study is a randomised, controlled, non-blinded, parallel clinical trial in which patients with established CKD are screened for OSA. Patients with OSA are randomised to either conventional medical therapy (control group) or medical therapy and CPAP (CPAP group) and followed for 1 year. The primary outcome is the change in estimated glomerular filtration rate. Secondary outcomes are the change in the urinary albumin/creatinine ratio, the Epworth Sleepiness Scale , Pittsburgh Sleep Quality Index and Kidney Disease Quality of Life questionnaire.Ethics and disseminationEthics approval has been obtained from the Conjoint Health Research Ethics Board (ID: REB15-0055). Results from this study will be disseminated through presentations at scientific conferences and publication in peer-reviewed journals.Trial registration numberNCT02420184; Pre-results.
How does priority setting for resource allocation happen in commissioning dental services in a nationally led, regionally delivered system: a qualitative study using semistructured interviews with NHS England dental commissioners
Authors: Vernazza Christopher Robert , Taylor Greig , Donaldson Cam , Gray Joanne , Holmes Richard , Carr Katherine , Exley Catherine 
Published: March 2019

ObjectivesTo understand approaches to priority setting for healthcare service resource allocation at an operational level in a nationally commissioned but regionally delivered service.DesignQualitative study using semistructured interviews and a Framework analysis.SettingNational Health Service dentistry commissioning teams within subregional offices in England.ParticipantsAll 31 individuals holding the relevant role (dental lead commissioner in subregional offices) were approached directly and from this 14 participants were recruited, with 12 interviews completed. Both male and female genders and all regions were represented in the final sample.ResultsThree major themes arose. First, ‘Methods of priority setting and barriers to explicit approaches’ was a common theme, specifically identifying the main methods as: perpetuating historical allocations, pressure from politicians and clinicians and use of needs assessments while barriers were time and skill deficits, a lack of national guidance and an inflexible contracting arrangements stopping resource allocation. Second, ‘Relationships with key stakeholders and advisors’ were discussed, showing the important nature of relationships with clinical advisors but variation in the quality of these relationships was noted. Finally, ‘Tensions between national and local responsibilities’ were illustrated, where there was confusion about where power and autonomy lay.ConclusionsCommissioners recognised a need for resource allocation but relied on clinical advice and needs assessment in order to set priorities. More explicit priority setting was prevented by structure of the commissioning system and standard national contracts with providers. Further research is required to embed and simplify adoption of tools to aid priority setting.
LUCSO-1—French pilot study of LUng Cancer Screening with low-dose computed tomography in a smokers population exposed to Occupational lung carcinogens: study protocol
Authors: Delva Fleur , Laurent François , Paris Christophe , Belacel Milia , Brochard Patrick , Bylicki Olivier , Chouaïd Christos , Clin Benedicte , Dewitte Jean-Dominique , Le Denmat Véronique , Gehanno Jean-François , Lacourt Aude , Margery Jacques , Verdun-Esquer Catherine , Mathoulin-Pélissier Simone , Pairon Jean-Claude 
Published: March 2019

IntroductionGuidelines concerning the follow-up of subjects occupationally exposed to lung carcinogens, published in France in 2015, recommended the setting up of a trial of low-dose chest CT lung cancer screening in subjects at high risk of lung cancer.ObjectiveTo evaluate the organisation of low-dose chest CT lung cancer screening in subjects occupationally exposed to lung carcinogens and at high risk of lung cancer.Methods and analysisThis trial will be conducted in eight French departments by six specialised reference centres (SRCs) in occupational health. In view of the exploratory nature of this trial, it is proposed to test initially the feasibility and acceptability over the first 2 years in only two SRCs then in four other SRCs to evaluate the organisation. The target population is current or former smokers with more than 30 pack-years (who have quit smoking for less than 15 years), currently or previously exposed to International Agency for Research on Cancer group 1 lung carcinogens, and between the ages of 55 and 74 years. The trial will be conducted in the following steps: (1) identification of subjects by a screening invitation letter; (2) evaluation of occupational exposure to lung carcinogens; (3) evaluation of the lung cancer risk level and verification of eligibility; (4) screening procedure: annual chest CT scans performed by specialised centres and (5) follow-up of CT scan abnormalities.Ethics and disseminationThis protocol study has been approved by the French Committee for the Protection of Persons. The results from this study will be submitted to peer-reviewed journals and reported at suitable national and international meetings.Trial registration numberNCT03562052; Pre-results.
Risk of depressive disorders after tobacco smoking cessation: a retrospective cohort study in Fukuoka, Japan
Authors: Fujita Takako , Babazono Akira , Harano Yumi , Jiang Peng 
Published: March 2019

ObjectiveWe sought to examine the effect of smoking cessation on subsequent development of depressive disorders.DesignThis was a retrospective cohort study.MethodsWe used administrative claim and health check data from fiscal years 2010 to 2014, obtained from the largest health insurance association in Fukuoka, Japan. Study participants were between 30 and 69 years old. The end-point outcome was incidence of depressive disorders. Survival analysis and Cox proportional hazards models were conducted. The evaluated potential confounders were sex, age, standard monthly income and psychiatric medical history.ResultsThe final number of participants was 87 255, with 7841 in the smoking cessation group and 79 414 in the smoking group. The result of survival analysis showed no significant difference in depressive disorders between the two groups. The results of Cox proportional hazards models showed no significant difference by multivariate analysis between participants, including users of smoking cessation medication (HR 1.04, 95% Cl 0.89 to 1.22) and excluding medication use (HR 0.97, 95% Cl 0.82 to 1.15).ConclusionsThe present study showed that there were no significant differences with respect to having depressive disorders between smoking cessation and smoking groups. We also showed that smoking cessation was not related to incidence of depressive disorders among participants, including and excluding users of smoking cessation medication, after adjusting for potential confounders. Although the results have some limitations because of the nature of the study design, our findings will provide helpful information to smokers, health professionals and policy makers for improving smoking cessation.
Cross-sectional study protocol for the Arabic Healthy Weight Project promoting active living and healthy eating among Arabic-speaking communities in South Western Sydney
Authors: Kovai Vilas , Arjunan Punitha , Weber Danielle , Rooney Janelle , Jalaludin Bin , Wardle Karen , Williams Mandy 
Published: March 2019

IntroductionThe South Western Sydney Local Health District (SWSLHD) is home to nearly 75 000 Arabic-speaking people. Of these, nearly three quarters are overweight or obese and suffer from a range of chronic diseases. To address this, the Health Promotion Service of SWSLHD will conduct a community-based overweight and obesity prevention intervention (Arabic Healthy Weight Project, 2018–2021) with Arabic community members aged between 18 and 50 years. The intervention’s main activities will include a comprehensive social marketing campaign and an ‘Eat-Move-Live Healthy’ programme.Methods and analysisThe project will be evaluated using a pre–postintervention study design to measure changes in practices in relation to physical activity, consumption of vegetables and intake of sugar-sweetened beverages. The evaluation will apply mixed data collection methods. The quantitative data will be collected using a face-to-face survey of 1540 participants from two independent samples (pre: 770 and post: 770). Descriptive and inferential statistical tests will be used to analyse the quantitative data. The qualitative component will use focus group discussions and interviews to evaluate the formative, process and follow-up phases of data collection. A combination of deductive and inductive methods of data analysis will be conducted using NVivo software.Ethics and disseminationThe protocol has been approved by the Human Research Ethics Committee of SWSLHD (HREC/16/LPOOL/303). Findings will be published in peer-reviewed journals.
Intimate partner violence victimisation in early adulthood: psychometric properties of a new measure and gender differences in the Avon Longitudinal Study of Parents and Children
Authors: Yakubovich Alexa R , Heron Jon , Feder Gene , Fraser Abigail , Humphreys David K 
Published: March 2019

ObjectivesTo evaluate the psychometric properties of a novel, brief measure of physical, psychological and sexual intimate partner violence (IPV) and estimate the overall prevalence of and gender differences in this violence.DesignData are from the Avon Longitudinal Study of Parents and Children (ALSPAC), a birth-cohort study.SettingAvon, UK.Participants2128 women and 1145 men who completed the questionnaire assessment at age 21.Outcome measuresParticipants responded to eight items on physical, psychological and sexual IPV victimisation at age 21. Participants indicated whether the violence occurred before age 18 and/or after and led to any of eight negative impacts (eg, fear). We estimated the prevalence of IPV and tested for gender differences using χ2or t-tests. We evaluated the IPV victimisation measure based on internal consistency (alpha coefficient), dimensionality (exploratory factor analysis) and convergent validity with negative impacts.ResultsOverall, 37% of participants reported experiencing any IPV and 29% experienced any IPV after age 18. Women experienced more frequent IPV, more acts of IPV and more negative impacts than men (p<0.001 for all comparisons). The IPV measure showed high internal consistency (α=0.95), strong evidence for unidimensionality and was highly correlated with negative impacts (r=0.579, p<0.001).ConclusionsThe prevalence of IPV victimisation in the ALSPAC cohort was considerable for both women and men. The strong and consistent gender differences in the frequency and severity of IPV suggest clinically meaningful differences in experiences of this violence. The ALSPAC measure for IPV victimisation was valid and reliable, indicating its suitability for further aetiological investigations.
Cost-effectiveness of a home-based group educational programme on renal replacement therapies: a study protocol
Authors: Redeker Steef , Oppe Mark , Visser Martijn , Busschbach Jan J V , Weimar Willem , Massey Emma , Ismail Sohal 
Published: March 2019

IntroductionLiving donor kidney transplantation (LDKT) is the optimal treatment for most patients with end-stage renal disease (ESRD). However, there are numerous patients who cannot find a living kidney donor. Randomised controlled trials have shown that home-based education for patients with ESRD and their family/friends leads to four times more LDKTs. This educational intervention is currently being implemented in eight hospitals in the Netherlands. Supervision and quality assessment are being employed to maintain the quality of the intervention. In this study, we aim to: (1) conduct a cost-effectiveness analysis of the educational programme and its quality assurance system; (2) investigate the relationship between the quality of the implementation of the intervention and the outcomes knowledge, communication and LDKT activities; and (3) investigate policy implications.Methods and designPatients with ESRD who do not have a living kidney donor are eligible to receive the home-based educational intervention. This is carried out by allied health transplantation professionals and psychologists across eight hospitals in the Netherlands. The cost-effectiveness analysis will be conducted with a Markov model. Cost data will be obtained from the literature. We will obtain the quality of life data from the patients who participate in the educational programme. Questionnaires on knowledge and communication will be used to measure the outcomes of the programme. Data on LDKT activities will be obtained from medical records up to 24 months after the education. A protocol adherence measure will be assessed by a third party by means of a telephone interview with the patients and the invitees.Ethics and disseminationEthical approval was obtained through all participating hospitals. Results will be disseminated through peer-reviewed publications and scientific presentations. Results of the cost-effectiveness of the educational programme will also be disseminated to the Dutch National Health Care Institute.Trial registration numberNL6529