bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choroidal neovascularization emerged right from the focal choroidal excavation in eyes with central serous chorioretinopathy post half-dose photodynamic therapy: A case report
Authors: Liu Yang , Wang Xin , Zhu Min , Xu Gezhi , Li Lei 
Published: November 2018

Abstract
Background: Focal choroidal excavation (FCE) is a common concurrent disease with central serous chorioretinopathy (CSC) and choroidal neovascularization (CNV). Photodynamic therapy (PDT), as the classic treating approach to CSC, appeared to increase the risk of CNV occurrence in eyes of CSC complicated with FCE. To observe and follow up the course development of eyes with CSC and concurrent FCE treated with half-dose photodynamic therapy (PDT).
Case presentation: In this case report analysis, two eyes with CSC and concurrent FCE, treated with half-dose PDT were followed up with monthly retinal fundus examinations. Best corrected visual acuity (BCVA) and ophthalmic fundus examination, including fundus photos, optical coherence tomography (OCT) and angiography. In case 1, a 46 year-old female has been diagnosed as CSC and concurrent FCE. The baseline BCVA was 10/20. Post half-dose PDT, complete resolution of SRF was achieved at one-month with stable BCVA. At three months, the patient complaint of obvious metamorphosis. Multimodal images confirmed the existence of CNV, derived from the FCE, inside the zone of PDT irradiation. The development of CNV ceased promptly one month post the injection of ranibizumab. In case 2, a 39 year-old male was diagnosed as bilateral CSC. The BCVA was 8/20 (od), and 16/20 (os). The multimodal images showed classic CSC manifestation in left eye, but atypical manifestation in right eye with subtle SRF and FCE. Post half-dose treatment, the SRF in left eye completely resolved at three-months, and the BCVA improved to 24/20. However, a lesion of CNV grew in FCE at one month in right eye, with decreased BCVA, 4/20. One month post-injection, apparent regression was witnessed, with improved BCVA, 6/20. The CNV proceeded to be a scar at two-month. The BCVA maintained at 8/20.
Conclusions: In this study, CNV was induced in two cases of CSC concurrent with FCE post half-dose PDT. The CNV grew right from FCE, inside the zone of PDT irradiation. Although half-dose PDT has proved to be safe in treating CSC, it appeared to increase the risk of CNV occurrence in eyes of CSC complicated with FCE.
In Silico and In Vitro Investigation of the Antifungal Activity of Isoeugenol against Penicillium citrinum
Authors: Ferreira Sávio Benvindo , Dantas Tassiana Barbosa , de Figuerêdo Silva Daniele , Ferreira Paula Benvindo , de Melo Thamara Rodrigues , de Oliveira Lima Edeltrudes 
Published: November 2018

Introduction:
This increase in the prevalence of drug-resistant pathogens occurs at a time when
the discovery and development of new antimicrobial agents occur slowly. In this context, the objective of
this study was to investigate the antifungal activity of isoeugenol, a phenylpropanoid, by in vitro and in
silico assays against Penicillium citrinum strains.

Material and Method:

For in silico analysis, the software PASS online, Molinspiration and Osíris were
used. For the determination of Minimum Inhibitory Concentration (MIC) and Minimal Fungicide Concentration
(MFC) of isoeugenol and voriconazole were carried out using the broth microdilution technique.
PASS online has shown that isoeugenol has the opportunity to present antiseptic, antifungal, antibacterial,
antimycobacterial activities. Molinspiration showed that the phytoconstituent has good potential for oral
bioavailability.

Conclusion:
In the analysis with the Osiris program, it was demonstrated that isoeugenol has low irritant
and tumorigenic risk. The MIC of isoeugenol varied between 256 and 32 µg/mL, MIC50 of 64 µg/mL and
MIC90 was 128 µg/mL. The MFC50, MFC90 and MFC of the isoeugenol for P. citrinum species were 64,
256 and 518 μg/mL, respectively. After analysis, it was verified that the isoeugenol have bactericidal effect
against the strains of P. citrinum. After these results, it is important to discover the mechanism of
action involved in the antifungal action of the compound, as well as in vitro and in vivo toxicity tests.
Combination Therapy of Apremilast and Biologic Agent as a Safe Option of Psoriatic Arthritis and Psoriasis
Authors: Metyas Samy , Tomassian Christopher , Messiah Ramy , Gettas Tina , Chen Christina , Quismorio Anne 
Published: November 2018

Introduction:
Psoriasis is a chronic immune-medicated inflammatory condition that affects
2-3% of the population, which can lead to psoriatic arthritis. There are multiple regimens for
the treatment of psoriasis including disease- modifying anti rheumatic drugs (DMARDS) and biologic
agent, phototherapy and apremilast. While monotherapy with biologic agents is effective for
many patients with psoriasis some patients are not satisfied by the outcome and require combination
therapy. No data exist on the safety of apremilast as a component of combination therapy with
biological therapies.

Objective:
The aim of the study was to determine the safety of apremilast in combination of biologic
therapies in the treatment of plaque psoriasis and psoriatic arthritis.

Methods:
This was retrospective study, open label study carried out at a single community Rheumatology
center. Twenty-two patients diagnosed with plaque psoriasis and psoriatic arthritis according
to American college of Rheumatology criteria-participated. Apremilast was added to their
current biologic agent. Patients were permitted to their current biologic treatment.

Results:
Out of 22 patients, six patients developed side effects, none of which caused discontinuation
of therapy. Out of the six patients who developed side effects, two patients developed nausea
and two patients developed diarrhea. One patient developed weight loss and one patient developed
abdominal pain.

Conclusion:
Apremilast can be safely combined with all biologic agents in patients with plaque
psoriasis or psoriatic arthritis not responding adequately to biologics alone.
High-Level Aminoglycoside Resistance in Enterococcus Faecalis and Enterococcus Faecium; as a Serious Threat in Hospitals
Authors: Khodabandeh Mahmoud , Mohammadi Mohsen , Abdolsalehi Mohammad Reza , Hasannejad-Bibalan Meysam , Gholami Mehrdad , Alvandimanesh Azadeh , Pournajaf Abazar , Rajabnia Ramazan 
Published: November 2018

Aims and Objectives:
The present work aimed to evaluate the frequency of aminoglycoside-
modifying enzymes encoding genes in the E. faecalis and E. faecium and their antibiotic
resistance profile.

Methods:
A total of 305 different clinical samples were subjected for identification and antibiotic
susceptibility test. The high-level aminoglycoside resistance was identified by MIC and Kirby
Bauer disc diffusion method. The prevalence of aac (6')-Ie-aph (2'')-Ia, aph (3')-IIIa and ant (4')-
Ia genes was determined by multiplex- PCR. In total, 100 enterococci strains were isolated. The
prevalence of E. faecalis and E. faecium isolates was 78% and 22%, respectively.

Results:
All isolates were susceptible to linezolid. So, all E. faecalis were susceptible to vancomycin
but, 36.4% of E. faecium were resistant to it. The prevalence of multiple drug resistance
strains was 100% and 67.9% of E. faecium and E. faecalis, respectively. High-level-gentamicin
and streptomycin resistant rates were as follows; 26.9% and 73.1% of E. faecalis and 77.3% and
90.1% of E. faecium.

Conclusion:
The results of the current study showed a high frequency of aac (6')-Ie-aph (2'')-Ia
genes among enterococcal isolates. A high rate of resistance to antimicrobials in Enterococcus is
obviously problematic, and a novel policy is needed to decrease resistance in these microorganisms.
Investor Reactions to Management Attributions: Revisions versus Late Filings Following Preliminary Earnings Announcements
Authors: Patelli Lorenzo , Victoravich Lisa M. 
Published: November 2018

ABSTRACT
After releasing preliminary earnings, firms may encounter accounting issues that cause them to announce an earnings revision or fail to meet a filing deadline. We experimentally examine how management attributions (accepting responsibility versus denying responsibility) influence investor reactions to these adverse financial reporting events. We find that investor reactions, as measured by perceptions of management trustworthiness and investment recommendations, to earnings revisions are more favorable (unfavorable) when managers accept (deny) responsibility by attributing the revision to an internal (external) factor. In contrast, investor reactions to late filings are not influenced by these management attributions. We also find that when the announcement does not quantify the earnings revision, accepting responsibility results in more favorable perceptions of management trustworthiness but not more favorable investment recommendations. These findings provide novel insights regarding variability in the effectiveness of management attributions to explain an adverse financial reporting event and the consequences for the public interest.
Data Availability: Contact the authors for data.
Investors' Responses to Reported Earnings when Management Issues Goal versus Expectation Earnings Guidance: An Experimental Investigation
Authors: Fanning Kirsten , Harris Ling , Jackson Kevin E. , Stern Matthew T. 
Published: November 2018

ABSTRACT
We investigate whether nonprofessional investors' responses to a company's reported earnings differ when management earnings guidance is presented as a goal or an expectation. We present 64 M.B.A. students and 262 MTurk participants with earnings guidance, manipulating between subjects whether management provides the guidance as a “goal” or an “expectation” and whether the company's reported earnings fall short or exceed investors' expectations as derived from management's earnings guidance. Our experimental results suggest that if earnings guidance is issued as a goal rather than as an expectation, investors respond less negatively when earnings fall short of investors' expectations, but not less positively when earnings exceed investors' expectations. Mediation analysis supports the interpretation that earnings falling short of investors' expectations leads investors to perceive managers as less competent and to be more disappointed when managers issue expectation rather than goal guidance, which in turn influences investors' attractiveness judgments of the company.
CITRA DESTINASI DAN PENGARUHNYA TERHADAP INTENSI UNTUK BERKUNJUNG KEMBALI DI SULAWESI SELATAN SEBAGAI DESTINASI PARIWISATA
Authors: AB Ahmad 
Published: November 2018

Salah faktor yang memengaruhi pengembangan pariwisata adalah citra destinasi. Setiap destinasi pariwisata harus menciptakan sebuah citra yang positif untuk menarik wisatawan memiliki intensi untuk berkunjung kembali. Penelitian ini bertujuan untuk menganalisis pengaruh langsung dan tidak langsung citra kognitif terhadap intensi wisatawan untuk berkunjung kembali ke Sulawesi Selatan. Convenience sampling digunakan untuk menentukan jumlah sampel penelitian. Data dikumpulkan melalui survey, dimana kuesioner diberikan kepada 546 wisatawan dan yang memenuhi syarat untuk diolah adalah 482 kuesioner. Data dianalisis menggunakan analisis jalur. Hasil penelitian mengindikasikan bahwa citra kognitif berpengaruh langsung terhadap intensi wisatawan untuk berkunjung kembali ke Sulawesi Selatan. Citra kognitif juga berpengaruh tidak langsung terhadap intensi wisatawan untuk berkunjung kembali melalui citra afektif.
A system consists of lifted steel tank and four assembly supports with variable assembly conditions
Authors: Zamorowski Jan , Gremza Grzegorz 
Published: November 2018

Abstract
In the method of steel tank erection, consisting in assembling the roof and the next courses (segments) of the shell at the ground level, starting from the top one (the so-called hydraulic jacking-up method), the assembled part of the tank is lifted using assembly supports (towers, trestles), hydraulic jacks and ropes. Supports are located inside or outside the tank, and their bases are usually not anchored. During the assembly work, numerous contaminations can appear under the bases of the supports; therefore, boundary conditions of the system consisting of the elevated tank and assembly supports may change, influencing the field of displacements and stresses in the elements of this system. This article presents the results of numerical tests of an exemplary mounted tank – mounting support system – at various possible coefficients of friction between the bases of the supports and the ground. The influence of the support conditions on the effort of the essential elements of the system was assessed. Calculation difficulty was noted to determine the directions of horizontal responses of the supports. It was assumed that these directions did not change after exceeding the values of the friction forces. The analysed tank collapsed during its erection.
MODEL MITRA GOVERNMENT DAN PRIVATE PARTNERSHIP DALAM MENINGKATKAN SERVICE QUALITY PADA RUMAH SAKIT DI JAWA TIMUR
Authors: Prabowo Bahtiar 
Published: November 2018

Penelitian ini bertujuan untuk mengetahui dan menganalisis peran swasta dalam meningkatkan kualitas layanan rumah sakit. Disamping itu penelitian ini juga bertujuan untuk membangun model kemitraan swasta dan pemerintah dalam meningkatkan kualitas layanan rumah sakit. Keberhasilan pemerintah dalam meningkatkan kualitas layanan di Rumah sakit tergantung pada semua pihak, termasuk dunia usaha, swasta dan masyarakat madani. Peran swasta dalam meningkatkan kualitas layanan rumah sakit di Jawa Timur relative masih kurang, hal ini ditunjukkan oleh hasil wawancara dengan pimpinan rumah sakit yang menjadi sampel penelitian. Hasil penelitian yang lain menunjukkan bahwa model kemitraan yang menguntungkan bagi pemerintah dan swasta adalah model kemitraan dengan KSO. Disamping itu hasil penelitian menunjukkan bahwa perlu ada kebijakan pemerintah berkaitan dengan peningkatkan kualitas layanan rumah sakit melalui kemitraan pemerintah dan swasta.Salah satu kebijakan pemerintah berkaitan dengan peningkatan kualitas layanan rumah sakit adalah dengan merubah model pengelolaan rumah sakit menjadi Badan Layanan Umum (BLU). Dengan model pengelolaan BLU diharapkan akan mampu meningkatkan kualitas layanan.
Ancient Curses in Bath: Oral Oaths, Lead Etchings, and the Impact on Biblical Interpretation
Authors: Johnson Lee A 
Published: November 2018

In 1979 the discovery of a cache of curse tablets from the sacred springs of the temple of Sulis Minerva in Bath brought to light some processes by which inscriptions were produced and employed by people outside of the upper class of Greco-Roman society. The tablets reveal that professional scribes were hired by supplicants to assist with the composition of their requests and the inscription onto lead tablets before being cast into the sacred spring. Such attention to the written form of the curses is intriguing in light of the fact that the majority of the supplicants could not read these inscriptions. In addition to the tablets that appear to be etched by professional scribes at Bath, there are also tablets that contain pseudo-inscriptions, mere markings that appear to be an attempt at replicating letters. These pseudo-inscriptions, while they did not contain the official lettering of a spoken curse, conveyed the added import that an etched tablet made to the supplication. The Bath tablets present a new view of the function of writing in a non-literate society, which has implications for the way that Biblical texts were viewed in their ancient contexts, vis-Ã -vis the oral transmission of the sacred message.
Experiences of Hearing Parents Following the Diagnosis of Their Child's Hearing Loss
Authors: Davids Ronel Sanet , De Jager Mariana 
Published: November 2018

An estimated 90Â per cent of children with a hearing loss are born to hearing parents. Most parents are unprepared for the diagnosis, leaving them shocked, confused, sad and bewildered. This article reports on a study aimed at exploring and describing the experiences of hearing parents regarding their childâ€™s hearing loss. The study was conducted in Cape Town, South Africa. The study applied a qualitative methodology with a phenomenological design. Purposive sampling was implemented and data were collected by means of unstructured in-depth interviews. Data were analysed using thematic analysis. Ethical considerations were adhered to. The main findings of the study indicated that hearing parents experience a myriad of emotions when their child is diagnosed with a hearing loss. This study advocates for various stakeholders in the helping profession to collaborate in the best interest of hearing parents and a child with hearing loss. Furthermore, these findings serve as guidelines for professionals working with these families.
Justice Ngcoboâ€™s Rich Legacy at the Intersection of Federalism and Democracy
Authors: Bronstein Victoria 
Published: November 2018

Â This article aims to make a connection between the Tongoane judgment, which deals with â€˜taggingâ€™ legislation, and Justice Ngcoboâ€™s innovative thinking in the Matatiele Municipality cases, which are about the demarcation of provincial boundaries. These cases are bound together by Justice Ngcoboâ€™s powerful commitment to democracy at the sub-national level. The judgments build accountability at grassroots level and constrain authoritarian impulses. This article examines the political issues behind provincial demarcation disputes, including ethnic impulses. It argues that current democratic concepts in South African Constitutional law can never meet the popular sovereignty, self-determinative type of claim of communities who wish to determine their own futures in boundary disputes. These disputes raise specific democratic problems that need to be named, seen for what they are and theorised on their own terms.Â
(Foto)performance no Sítio Arqueológico de Pompeia, Itália
Authors: Opa Matheus Kayssan 
Published: November 2018

O presente artigo propõe uma reflexão sobre uma tarde performática no Sítio Arqueológico de Pompeia, Itália, cidade destruída por uma erupção do vulcão Vesúvio cujas ruínas permanecem sendo alvo de turistas. Assim, tendo tal lugar como catalisador poético, como o artista se entende em um espaço turístico? Como ele pode se portar? Para responder tais questionamentos, trago as teorias da Deriva de Guy Debord (1931 – 1984) e sobre o flâneur de Walter Benjamin (1892 – 1940). Artista-turista é esse que flana pelas ruas procurando (ou não) algo que não sabe o que é, derivando, sentindo o sabor do urbanismo pelo seu tato. O texto explora como foi a viagem-obra às ruínas, como a performance se fez e os desdobramentos poéticos do registro além de uma reflexão sobre o que é ser turista e artista ao mesmo tempo.
¿POR QUÉ “INFORMÁTICA JURÍDICA” HOY (2018)?
Authors: Galindo Fernando , Lasala Pilar 
Published: November 2018

El trabajo plantea que no cabe pensar en 2018 que la expresión “informática jurídica” existe porque hay una disciplina académica que tiene el mismo nombre, sino que se utiliza porque es el modo de expresar la satisfacción de necesidades sociales relacionadas con el uso de las tecnologías de la información y la comunicación por medio del ejercicio conjunto, interdisciplinar, ante problemas concretos, de competencias profesionales propias de juristas y de ingenieros informáticos.
SOCIAL SUPPORT AS A FACTOR OF CHRONIC SOCIAL STRESS IN MEN OF OPEN CITY POPULATION (BASED ON THE MODEL OF TYUMEN)
Authors: Akimova E. V. , Akimov M. Yu. , Gakova E. I. , Gafarov V. V. , Kuznetsov V. A. 
Published: November 2018

The aim of the work was to establish levels of social support in an open urban population for men aged 25–64 years.Material and Methods. Cross-sectional epidemiological study was conducted in 1000 males using a representative sample formed by the method of «random numbers» taken from the electoral lists of the Central Administrative District of Tyumen, the response was 85.0%. Social support was evaluated using the Beckmann‑Sim test on the basis of the World Health Organization questionnaire «MONICA‑psychosocial».The results of the study showed that in an open urban population in men aged 25–64 years and in certain age groups, a predominantly low and medium index of close contacts was established. Men of working age are dominated by the medium-high and average index of social ties; in the sixth decade of life, the low index of social ties reaches an absolute maximum, a high index of social ties-an absolute minimum.Discussion. The scientific literature shows that people with high levels of social interaction have better health than those with low levels. Therefore, it is important to study the changes in the social support factor in the population as one of the protective social mechanisms that mitigate the negative consequences of stress. Conclusion. The patterns established in men of an open urban population according to the levels of social support are the scientific basis for planning socially-oriented preventive programs in medium-urbanized Siberian cities.
SARCOIDOSIS IN ACTUAL CLINICAL PRACTICE
Authors: Evlampieva L. G. , Yaroslavskaya E. I. 
Published: November 2018

Heart damage in case of sarcoidosis is associated with high risk of a sudden death; and its verification is very complicated due to lack of pathognomonic symptoms. In this article, we present a review of problems and abilities of cardiac sarcoidosis diagnosis, and main trends of its treatment.
CLINICAL-DYNAMIC AND BIOLOGICAL ASPECTS OF POLYMORPHISM AND EFFICACY OF THERAPY OF MOOD DISORDERS
Authors: Schastnyy E. D. , Simutkin G. G. , Lebedeva E. V. , Yakovleva A. L. , Losenkov I. S. , Repin A. N. , Nonka T. G. 
Published: November 2018

Objective: to study clinical-biological features of affective disorders including their comorbidity with coronary artery disease and personality disorders and efficacy of psychopharmacotherapy in these patients.Material and Methods. In the first group at a heart station 290 patients with chronic coronary artery disease and affective disorders (209 men and 81 women) were fully examined. The second group included 120 patients (40 men and 80 women) of a psychiatric hospital with affective disorder comorbid with personality disorders. The third group included the study of 29 patients with depressive disorders and a control group (n=21).Results. Data on significant clinical-dynamic, biological and therapeutic features of affective disorders comorbid with coronary artery disease were obtained. It was revealed that presence of a comorbid personality disorder in the case of affective disorders causes the necessity to use a combined psychopharmacotherapy more frequently, worsens indicators of the efficacy of the psychopharmacotherapy of current episode of depression, and increases negative estimation of their social adaptation by these patients. Dysregulation of the processes of programmed cell death in patients with depressive disorders was found.Conclusion. Obtained data testified to the high degree of comorbidity of affective disorders with coronary artery disease and personality disorders which worsened the prediction of the course and indicators of the efficacy of psychopharmacotherapy of these disorders. In patients with depressive disorders the specific weight of mononuclears of peripheral blood was increased in the state of apoptosis.