bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reporte de caso: Trasplante Renal en un paciente con Epidermolisis Bullosa
Authors: Saad Emanuel José , Albertini Ricardo Arturo , Chiurchiu Carlos , Massari Pablo Ulises , De la Fuente Jorge Luis 
Published: August 2018

<p>La epidermolisis bullosa distrófica recesiva (EBDR) es una genodermatosis extremadamente infrecuente, caracterizada por la existencia de alteraciones a nivel de las fibras de anclaje que unen la membrana basal de la epidermis a las estructuras subyacentes. Un elemento característico de esta entidad es la formación recurrente de ampollas en piel y mucosas ante traumatismos mínimos, con posterior cicatrización. Los pacientes con EBRD frecuentemente desarrollan enfermedad renal crónica y requieren de terapia de reemplazo renal, constituyendo una importante causa de morbilidad y mortalidad en estos pacientes. El rol del trasplante renal es poco conocido en este tipo de pacientes.</p>Se presenta el caso de un paciente con enfermedad renal terminal y EBDR que es tratado con trasplante renal y su seguimiento a lo largo de un período de 83 meses luego del trasplante. Durante dicho período se observó una baja frecuencia de intercurrencias infecciosas, así como la ausencia de desarrollo de neoplasias cutáneas. El trasplante renal podría ser una alternativa a la terapia de reemplazo dialítica en los pacientes con epidermolisis bullosa asociada a enfermedad renal terminal, reduciendo las comorbilidades asociadas a las terapias dialíticas.
Effect of sugarcane genotypes and 2, 4-dichlorophenoxy acetic acid on callus induction
Authors: Subedi M. , Ojha B. R. , Ghimire S. K. , Joshi B. K. , Niroula R. K. , Sah B. P. , Chaudhary R. , Kharel R. , Poudel A. P. 
Published: August 2018

Callus induction is an important step in in-vitro culture valued for micropropagation, somaclonal variation, mutagenesis, synthetic seed production, transformation and genetic engineering. Callusing response of ten sugarcane genotypes viz., BO-110, BO-134, Cose-95422, Cose-98232, Cose-92423, UP-9742, BO-91, BO-135, and Cose-98255, were studied under three different doses (2, 3 & 4 mg L-1) of 2,4-D supplemented in the callus induction media. Callus induction was found to depend on both genotype and 2,4-D concentration in the media. The genotype UP-9742 was most amenable to callus induction (67.50%) followed by Cose-97182 (56.25%) and Cose-92423 (51.00%). While, the media supplemented with 3 mg L-1 2,4-D was found more effective to trigger callus induction in general. Yet, the optimum dose of 2,4-D to be used depends on the interaction of the specific genotype. Journal of the Institute of Agriculture and Animal Science.Vol. 33-34, 2015, page: 237-242
POLA PENGASUHAN ANAK DAN PROSES INTERNALISASI NILAI BUDAYA BERBASIS AJARAN ISLAM DI KAMPUNG JAWA-TONDANO
Authors: Djakaria Salmin 
Published: August 2018

<p>Artikel ini bertujuan mendeskripsikan model-model internalisasi nilai budaya berbasis ajaran agama Islam pada masyarakat kampung Jawa-Tondano di Minahasa dan bagaimana hal tersebut berperan dalam proses pembentukan karakter warganya. Proses internalisasi nilai ini dilakukan terutama lewat seni tutur, yaitu dengan menandungkan: Salawat, pantun, ungkapan-ungkapan dan nasehat. Seni tutur sebagaimana yang dijelaskan dalam artikel ini tidak hanya bermanfaat dalam menginternalisasi nilai-nilai Islami, tetapi juga menjadi salah satu faktor pembentuk karakter orang Jaton. Disamping itu, seni tutur yang dimaksud juga membentuk sebuah identitas yang memperkuat ikatan mereka sebagai orang Jaton, sehingga sekalipun bermukim di luar kampung, tetap memiliki ikatan dengan kampung halamannya. Artikel ini didasarkan pada penelitian lapangan dengan menggunakan metode kualitatif yang teknik pengumpulan datanya terutama lewat wawancara, observasi dan lewat Focus Group Discussion (FGD) yang difokuskan pada pendekatan pengalaman individu.</p>
KIPRAH SETENGAH ABAD YAYASAN PENDIDIKAN ISLAM (YAPIS) PAPUA: MEMBANGUN HARMONI BERAGAMA MELAUI DUNIA PENDIDIKAN
Authors: Nuruddin Sabara 
Published: August 2018

<p>Penelitian ini adalah penelitian tentang kiprah Yayasan Pendidikan Islam (YAPIS) Papua di Kota Jayapura dalam upaya membangun harmoni kerukunan umat beragama (KUB) di Jayapura. Masalah peenelitian Bagaimana perspektif dan praktek KUB dari kelompok YAPIS Papua?, dan bagaimana meletakkan perspektif dan praktek KUB dari YAPIS dalam konteks Papua?.Penelitian dilakukan dengan metode kualitatif deskriptif. YAPIS Papua mengembangkan perspektif tentang KUB didasarkan pada pandangan tentang Islam yang moderat dan inklusif yang dibangun di atas prinsip Islam <em>rahmatan lil alamin. </em>Melalui lembaga pendidikan dari jenjang PAUD hingga perguruan tinggi YAPIS berkiprah sebagai lembaga pendidikan yang terbuka, inklusif, dan toleran dengan memberikan pelayanan pendidikan yang sama kepada putra-putri Papua tanpameihat latar belakang etnik dan agama. Prinsip Islam yang moderat dan toleran diperkenalkan kepada peserta didik melalui kurikulum Pendidikan Agama Islam dan ke-YAPIS-an melalui kurikulum berbasis kemajemukan. YAPIS di Tanah Papua dalam setengah abad kiprahnya telah berhasil mengembangkan <em>role of model </em>tolerans yang tepat untuk konteks masyarakat Papua yang multikultur. Secara sosioogis, YAPIS berhasil merekatkan jarak antara ke-Islam-an dan ke-Kristen-an di Tanah Papua melalui kiprahnya di dunia pendidikan.</p><p> </p>
Evaluation of dietary Intake and Food Patterns of Adolescent Girls in Sistan and Baluchistan Province, Iran
Authors: Montazerifar Farzaneh , Karajibani Mansour , Dashipour Ali Reza 
Published: August 2018

Background: The evidence suggests a relationship between lifestyle and diet-related risk factors.Objective: This study assessed the dietary intake and habits of high school girls in Sistan and Bluchistan province, in southeastern Iran.Methods: In a cross-sectional, descriptive study, 753 high school girls aged 14-18 years old wereenrolled by a clustered random sampling method. Dietary intake and food habits were evaluated by a two-day, 24-hour dietary recall, and a food frequency questionnaire (FFQ).Results: The analysis of dietary intakes showed that energy, calcium, zinc, vitamin C and folate intake, compared to the Dietary Reference Intake (DRI), were found to be lower. The, infrequent intake of milk and dairy products, fruits and vegetables, and a high consumption of empty calorie foods e.g. salty snacks, sweets, soft drinks and junk foods were seen among adolescents.Conclusions: The adolescent girls had an improper dietary intake and food habits. Thus, the implementation of nutrition education programs in schools and the designing of proper patterns towards healthier food choices could help improve eating behaviors, the health maintenance of adolescents, and also prevent diet- related diseases in adulthood.Key words: Adolescent girls, Dietary intake, Food habits
Impact effect of lycopene and tomato-based products network on cardio-protective biomarkers in vivo
Authors: El-Nashar Nermin N. , Abduljawad Soha Hashim 
Published: August 2018

Background: Dietary intake plays an important role as nutritional supplements are known to provide potential health benefits in cardiovascular disease. Recent studies suggest that the dietary intake of tomatoes and tomato products containing lycopene are associated with a decreased risk of cardiovascular disease. In order to substantiate these facts, the present study was undertaken to investigate the effectiveness of lycopene from tomato products on the potential effects of oxidative stress and atherosclerosis in vivo, focusing on early atherosclerotic events.Methods: Thirty male albino rats were assigned randomly into 5 groups; group C was the negative control group fed a basal diet, group H was the positive control fed a high-fat diet (HFD), group TS (HFD) was fed a 8% lyophilized tomato paste, group TW (HFD) was fed a 24% lyophilized raw tomato, and group L (HFD) was fed 0.1% mg pure lycopene. The level of serum; total cholesterol (TC), total triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c) was measured after 8 weeks of experimental treatment. Malondialdehyde (MDH) plasma levels were measured in heart tissue homogenate. Furthermore, pathologic changes of the heart and aorta were also assessed.Results: We found that TC, TG, LDL-c and MDH, levels were significantly increased in group H (P < 0.05) compared to the negative control group. Administration of TS, TW and L demonstrated significant changes in these parameters (P < 0.05). The TW group (fed 24% of lyophilized raw tomato components) had more positive effects than the TS & L groups. Furthermore, morphologic changes of heart and aorta revealed that TW and TS had a similar preventive effect against the development of atherosclerosis.Conclusion: Our study indicated that raw tomatoes have a higher potential effect when compared to tomato paste or lycopene alone. This potential effect includes the ability to attenuate and/or reverse oxidative stress and other atherosclerosis related parameters induced by the consumption of a high-fat diet.Key words: Cardioprotective, Lipid profile, Lycopene, Oxidative stress, Tomatoes products
Breast cancer prevention with Morinda citrifolia (noni) at the initiation stage
Authors: Wang Mian-Ying , Peng Lin , Anderson Gary , Nowicki Diane 
Published: August 2018

Background: It has been reported that noni has multiple health benefits for over 2000 years. In this study, the cancer preventive effects of Tahitian noni® juice (TNJ) at the initiation stage on DMBA-induced mammary tumorigenesis in female SD rats was investigated.Objective: We took advantage of the DMBA-induced mammary carcinogenic model to study the preventive effects of TNJ at the initiation stage of mammary carcinogenesis in female SD rats by using clinical observation, pathological examination, and 32P-postlabeling assay.Methods: One hundred and sixty female SD rats were divided into eight groups with 20 rats in each group. Three doses of TNJ or placebo was given to the animals at the age of 35 days until the end of the experiment. When the animals were 55 days old, 25 mg/kg DMBA was fed to the animals in the DMBA group, placebo, and TNJ groups. The 20 rats were kept at age-matched controls. Palpable tumors were examined twice a week after DMBA administration in each group by an experienced professional. The size of tumor was measured by a graduated caliper. A piece of tumor, vascularization area, and mammary glands in the thoracic and abdomen areas of each rat were dissected respectively and fixed in 10% neutral buffered formalin for light microscope examination. The DMBA-DNA adduct formation in mammary tissues was detected by 32P-postlabeling assay.Results: The tumor latency in TNJ groups was delayed about 60-90 days when compared with positive controls. The number of palpable tumors per group was significantly reduced by 73%, 72% and 80% in 3%, 5%, and 10% TNJ groups respectively when compared with positive controls at the end of 330 days after DMBA administration. The number of palpable tumors in the placebo groups was slightly reduced in the early stage, but much less than that in the TNJ groups. The multiplicity and malignancy of lesions were significantly reduced and the survival rate of animals in the TNJ groups was significantly increased compared with positive controls at different time points. Histological examination showed that the malignancy of lesions in TNJ groups did not show a significant change when compared with that in positive and placebo groups. Conclusion: In conclusion, this is the first study which indicates that TNJ possesses a cancer preventive effect at the initiation stage of chemical carcinogenesis induced by DMBA in female SD rates. Key words: Morinda citrifolia, Tahitian noni® juice, breast cancer, cancer prevention
Effect of a dietary supplement containing kurozu (a Japanese traditional health drink) concentrate on several obesity-related parameters in obese Japanese adults: a randomized, double-blind, placebo-controlled trial
Authors: Hamadate Naobumi , Nakamura Ken-ichiro , Hirai Motoko , Yamamoto Tetsuro , Yamaguchi Hideyo , Iizuka Muneaki , Yamamoto Etsushi , Iwama Yoshitaka , Yazawa Kazunaga 
Published: August 2018

Objective: This study was undertaken to examine the Kurozu concentrate (KC) based dietary supplement on several obesity-related parameters in obese Japanese male and female adults.Background: Kurozu, which is a specific type of rice vinegar produced by fermentation of unpolished brown rice, has long been used as a traditional health food and folk medicine in Japan. A recent animal study and our preliminary human study suggest that the KC supplement has potential for use in the management of obesity.Materials and Methods: A 12-week, randomized, double-blind, placebo-controlled trial was conducted involving 48 Japanese adult subjects (28 males and 20 females) with obesity. Subjects were either assigned to the group consuming the KC supplement for 12 weeks (870mg/day; 480 mg/day as KC) (n=24; 14 males and 10 females) or the placebo group (n=24; 14 males and 10 females). All test participants were assessed using several obesity-related parameters, including body weight, BMI, waist circumference, and abdominal fat computed tomography (CT) sections. These measurements took place at baseline and at week 12. Results: At week 12, a significant decrease in body weight (P<0.043) and nearly significant decreased values of BMI (P=0.052) were observed in the KC group compared to the placebo group. The reduction in waist circumference at week 12 within the KC group was not significantly greater than the placebo group. Examination of abdominal CT sections around the navel indicated that, although most of the values of the total fat area, subcutaneous fat area, and visceral fat area for both of the placebo and KC groups significantly increased during the 12-week intervention, the magnitude of increase in the total fat area for all subjects and that of the total fat area, subcutaneous fat area, and visceral fat area for females on one or more of three CT sections were significantly lower in the KC group than the placebo group (P<0.05).Conclusion: Although the results are not definitive, KC supplementation may have potential for improving some obesity-related parameters in obese subjects, particularly females.Key words: Kurozu concentrate (KC), KC-based dietary supplement (KC supplement), abdominal obesity-related parameters, body mass index (BMI), computed tomography (CT), abdominal fat
Intake of Mung Bean Protein Isolate Reduces Plasma Triglyceride Level in Rats
Authors: Tachibana Nobuhiko , Wanezaki Satoshi , Nagata Mayuko , Motoyama Takayasu , Kohno Mitsutaka , Kitagawa Sayuri 
Published: August 2018

Background: Mung bean is well known as a starch source, but the physiological effects of mung bean protein have received little attention. In this study, we isolated mung bean protein from de-starched mung bean solutions, and investigated its influence on lipid metabolism. Objective: The aim of this study is to clarify the influence of the lipid metabolism by consumption of mung bean protein isolate (MPI)Methods: Diets containing either mung bean protein isolate (MPI) or casein were fed to normal rats for 28 days.Results: Both groups ate the same amount of food, but the plasma triglyceride level, relative liver weight and liver lipid contents (cholesterol and triglyceride pool) in the MPI group were significantly lower than in the casein group. In the MPI group, the expression of sterol regulatory-element binding factor 1 (SREBF1) mRNA in the liver was significantly different when compared with the casein group. The significantly lower levels of insulin and free fatty acids in the MPI-fed rats may be due to the regulation of genes related to lipid metabolism in the liver.Conclusions: These results suggest that MPI may improve the plasma lipid profile by normalizing insulin sensitivity.Keywords: mung bean, Vigna radiata L., 8S globulin, triglyceride, β-conglycinin, 7S globulin, insulin sensitivity, SREBF1
Effect of some Tropical Eggplant Fruits (Solanum Spp) Supplemented Diet On Diabetic Neuropathy In Experimental male Wistar Rats In-vivo
Authors: Nwanna Esther E. , Ibukun Emmanuel O. , Oboh Ganiyu 
Published: August 2018

Background: Solanum known as eggplant is a popular vegetable crop grown in the subtropics and tropics. Eggplant is a perennial but grown commercially as an annual crop. The fruits of eggplant is primarily used as a cooking vegetable for various dishes. Eggplant comes in various kinds of species, which are highly variable for its fruit colour, as well as shape and size.Content and Purpose of this study: This study focused on comparing the effect of dietary African eggplants (AP) Solanum kumba,(PG) Solanum gilo (PW) and Solanum aethiopicum (PGW) species. Diabetes was induced experimentally by high fat fed/low dose streptozotocin-diabetic rats (35 mg/kg body wt.) and the diabetic rats were fed diets supplemented with 20–40% supplemented eggplant diet for 14 days. The effect of the diets on the blood glucose level, pancreatic α-amylase, intestinal α-glucosidase and Angiotensin-I converting enzyme (ACE) activities, plasma antioxidant status were determined also quantification of the fruits polyphenols using HPLC/DAD .Results: The results revealed that there was no significant (P < 0.05) difference in the average feed intake and weight changes in all the groups. Supplementation with eggplant diet gradually reduced blood glucose level in diabetic rat compared to diabetic rats and metformin-treated (positive control group). African eggplant showed elevated levels of antioxidant status such as (glutathione peroxidase GPX, glutathione transferase GST,reduced glutathione GSH,Catalase and Ascorbic acid).Conclusions:The results suggest that the eggplant may attenuate hyperglycemia, hypertension and oxidative stress in the type 2 diabetic condition with Solanum kumba having the highest activity which could not be far fetched from its polyphenols as revealed in the HPLC/DAD characterization.Keywords: Solanum spp,polyphenols, diabetes,enzymes
Investigation of Phytochemical Constituents, Phenolic Profiles and Antioxidant Activities of Ricegrass Juice compared to Wheatgrass Juice
Authors: Chomchan Rattanamanee , Siripongvutikorn Asst. Prof. Dr. Sunisa , Puttarak Dr. Panupong , Rattanapon Ms. Rungtip 
Published: August 2018

Background: Cereal grass has been brought attention as a new functional food. Wheatgrass juice was known as a super food which provides lots of advantages for human health. However, the young stage of rice sprout has not been made widely known for consumption, though it is in the similar family to wheat (Poaeceae). Accordingly, ricegrass juice can and should be introduced, especially in Asian countries, as an economical functional drink. Nevertheless, currently there is none of the apparent evidences which confirm the nutritive values of ricegrass juice compared to wheatgrass juice.Objective: To investigate the chemical compositions, major phytochemical constituents, bioactive compounds content, specific phenolic profiles, and in vitro antioxidant activities of ricegrass juice compared to wheatgrass juice. Methods: Rice and wheat seeds were germinated and grown hydroponically for 8 days. Both fresh plants were determined for chemical compositions. Next, the grasses were extracted with water, centrifuged, and the supernatants were tested for chlorophyll, carotenoid, and ascorbic acid contents. The left-over supernatant were freeze-dried. The extracts were then screened for the main group of phytochemicals, total extractable phenolic and specific phenolic compounds. Lastly, the extracts were tested for the antioxidant activities using DPPH, ABTS, FRAP, FCA and HRSA. Results: Data revealed that wheatgrass contained higher levels of protein and fat. Both ricegrass and wheatgrass juice extract exhibited the group of phenol, tannin and saponin but not alkaloid, flavonoid, sterol, terpenoid, courmarin, and cardiac glycoside. Wheatgrass juice can be detected for higher level of ascorbic acid and chlorophyll. Both grass juices were found the similar phenolic acids analyzed by HPLC included pyrogallol, vanilic acid, syringic acid and ferulic acid, however, ricegrass juice contained larger amounts of all phenolic acids excluding syringic acid. Conversely, wheatgrass juice exposed higher antioxidant activities for all methods. This may propose from the synergistic effects of ascorbic acid, chlorophyll, and phenolic compounds in wheatgrass juice, while the main composites exhibited antioxidant activities in ricegrass were phenolic compounds.Conclusion: Ricegrass juice contained great level of phenolic acid molecules. Even if ricegrass juice gave less statistically ability on antioxidant activities, they still had comparable levels of antioxidant activities. With the reduction in cost of raw materials and contribution of high nutritional values, ricegrass juice could be introduced as an antioxidant boosting drink in competition to wheatgrass juice.Keywords: Antioxidant, Phytochemical, Phenolic compounds, Ricegrass, Wheatgrass
Oral administration of an ethanolic extract of Hypericum gentianoides attenuates spontaneous colitis in mdr1a-/- mice
Authors: Haarberg Kelley M. K. , Wymore Brand Meghan J. , Ramer-Tait Amanda E. , Hauck Catherine C. , Murphy Patricia A. , Hostetter Jesse M. , Wannemuehler Michael J. 
Published: August 2018

Background: Nutraceuticals (i.e., complementary and alternative medicines) are gaining ground as therapeutic modalities for inflammatory and autoimmune disorders due to their low toxicity and high patient compliance. Several species of Hypericum have been shown to possess immunomodulatory capabilities in many disease models; however, the therapeutic potential of the chemically unique Hypericum gentianoides (HG) is largely untested. We investigated the efficacy of an orally administered ethanolic extract of HG (HGEE) to prophylactically inhibit/ameliorate the spontaneous colitis that develops in mdr1a deficient (mdr1a-/-) mice.Methods: Beginning at six weeks of age, vehicle (5% ethanol), HGEE (4.8 mg/day) or metronidazole (0.75 mg/mL) were orally administered daily to mdr1a-/- or FVBWT mice until they reached 20 weeks of age or had lost ≥ 15 % of their body weight. Macroscopic disease assessment included measurement of weight loss, colon shortening, and combined colonic/cecal macroscopic lesion scores. Colonic/cecal inflammation was also scored histologically. Inflammatory responses were assessed using myeloperoxidase (MPO) assay and analysis of serum cytokines/chemokines.Results: Daily administration of HGEE significantly (p < 0.05) delayed the onset of clinical signs of disease, reduced the associated morbidity and attenuated macroscopic and microscopic disease/inflammatory scores in mdr1a-/- mice. After 14 weeks of treatment, there were no adverse macroscopic or microscopic effects observed following the daily administration of HGEE to wild type FVB mice. Histological evaluation of colonic tissue revealed a decrease in neutrophil infiltration in HGEE treated mdr1a-/- mice, which was substantiated by a significant decrease (p ≤ 0.05) in colonic MPO activity. Compared to vehicle treated mdr1a-/- mice, levels of G-CSF, KC, and TNFα were significantly lower in the serum of mdr1a-/- mice treated with HGEE.Conclusions: Oral administration of HGEE was shown to be safe and effectively ameliorated mucosal inflammation and disease severity in mdr1a-/- mice. The attenuation of mucosal inflammation correlated with a reduction in the production of pro-inflammatory cytokines and the recruitment of inflammatory granulocytes to the intestinal mucosa and suggests that extracts of H. gentianoides has potential to be used as a CAM product for mucosal inflammation.Keywords: Hypericum gentianoides, colitis, IBD, mdr1a deficient mice, botanical