bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microwave-assisted synthesis of quinazolin-4(3H)-ones catalyzed by SbCl3
Authors: Kang Huaiyuan , Wang Weili , Sun Qinqiang , Yang Shuya , Jin Juan , Zhang Xuewen , Ren Xiaoliang , Zhang Jiming , Zhou Jianhua 
Published: November 2018

Abstract
Antimony(III) trichloride (SbCl3) is an effective catalyst (1 mol%) for the condensation of anthranilic amide with various aldehydes or ketones to quinazolin-4(3H)-one derivatives in good to excellent yields under microwave irradiation. The process is carried out within several minutes under solvent-free conditions. This general methodology has the advantages of simplicity, mild reaction conditions and high yields of products.
Synthesis and bioactivity of novel C2-glycosyl oxadiazole derivatives as acetylcholinesterase inhibitors
Authors: Wang Lei , Wu Yu-Ran , Ren Shu-Ting , Yin Long , Liu Xiu-Jian , Cheng Feng-Chang , Liu Wei-Wei , Shi Da-Hua , Cao Zhi-Ling , Sun Hui-Min 
Published: November 2018

Abstract
A series of glycosyl-substituted 1,3,4-oxadiazoles were synthesized by cyclization of glycosyl-acylthiosemicarbazides via a base-catalyzed reaction. The starting glycosyl-acylthiosemicarbazide derivatives were obtained by the reaction of glycosyl isothiocyanate with various hydrazides. The acetylcholinesterase (AChE) inhibitory activities of the products were tested by Ellman’s method. The most active compounds were subsequently evaluated for the 50% inhibitory concentration (IC50) values. N-(1,3,4,6-tetra-O-benzyl-2-deoxy-β-D-glucopyranosyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole-2-amine (6i) possesses the best AChE -inhibition activity with an IC50 of 1.61±0.34 μm.
Evolution of Interfacial Features of MnO-SiO2 Type Inclusions/Steel Matrix during Isothermal Heating at Low Temperatures
Authors: Zhang Xueliang , Yang Shufeng , Li Jingshe , Liu Chengsong , Hao Wei-xing 
Published: November 2018

Abstract
To clarify the evolution of interfacial features between MnO-SiO2 type inclusions and Si-Mn killed steel during isothermal heating at low temperatures, two diffusion couple samples were investigated under heat treatment at 1173 K and 1273 K, respectively. The experimental results show that the diffusion of oxygen from the oxide to the alloy is the restrictive link of the solid-state reaction between MnO-SiO2-FeO oxide and steel matrix at low heating temperatures. With increasing heating time or temperature, more FeO in the oxide decomposed, and the resulting oxygen diffused into the alloy and reacted with Mn and Si elements. The critical heating temperature at which the interfacial reaction can occur was determined to be 1173 K. And a dynamic model that predicts the change in the width of the particles precipitation zone at low temperatures was also established based on Wagner equation.
Humor as social risk-taking: The relationships among humor styles, sensation-seeking, and use of curse words
Authors: Kennison Shelia M. , Messer Rachel H. 
Published: November 2018

AbstractThe research investigated the view that using humor can be a form of social risk-taking, as the attempt at humor may not always be viewed positively by others. Prior research has shown that individuals’ levels of sensation-seeking, a personality variable related to risk-taking, was related to humor appreciation. Other research has shown that sensation-seeking also predicted the use of curse words, another form of verbal risk-taking. The present research tested two hypotheses: a) sensation-seeking positively relates to each of the four humor styles and b) the use of curse words also positively relates to each of the four humor styles. The results obtained from a large sample of undergraduate students partially supported the hypotheses. Multiple regression analyses using the hierarchical approach further showed that sensation-seeking predicted two of the four humor styles for men (i.e. affiliative, aggressive) and two of the four for women (i.e. aggressive and self-defeating). The use of curse words predicted variance not explained by variation in sensation-seeking in the use of the aggressive humor style in men and women and for the affiliative humor style only for men. Overall, men reported higher levels of aggressive humor, sensation-seeking, and cursing than women. Implications for theoretical perspectives on humor and social risk-taking are discussed.
Influence of eugenol on oxidative stress biomarkers in the liver of carrageenan-induced arthritis rats
Authors: Adefegha Stephen Adeniyi , Oyeleye Sunday I. , Okeke Bathlomew M. , Oboh Ganiyu 
Published: November 2018

Abstract

Background
Eugenol is the foremost constituent of clove oil and widely distributed in many plants. It possesses many pharmaceutical applications, including antioxidant, anti-inflammatory, and anti-tumorigenic properties, among others. This study evaluates the influence of eugenol on oxidative stress biomarkers in the liver of carrageenan-induced arthritis (CIA) rats.

Methods
Sixty albino rats were randomly divided into 10 (n=6) groups. Group I is the control group that received saline solution orally. Groups II and VII rats received 2.5 mg/kg of eugenol orally (EUG-2.5). Rats in groups III/VIII and IV/IX received 5 and 10 mg/kg of eugenol orally (EUG-5 and EUG-10), respectively. Groups V and X received 0.2 mg/kg of dexamethasone (DEX-0.2) orally. Groups VI to X were injected with 1% carrageenan intra-articularly. Behavioral studies were conducted after 21 days of treatment. Thereafter, the animals were sacrificed, and the livers were isolated and used for biochemical analysis.

Results
Reduced body weight in arthritic rats was recorded compared to normal controls. Reduced tibiofemoral joint edema and increased spontaneous movement were observed in CIA rats with decreased superoxide dismutase, catalase, reduced glutathione (GSH), glutathione peroxidase, and GSH S-transferase activities compared with the normal control group. Increased endogenous enzyme activities and decreased elevated lipid peroxidation were also observed after eugenol treatment.

Conclusion
Eugenol ameliorates carrageenan-induced oxidative stress in the liver of arthritic rats.
An effective algorithm for globally solving quadratic programs using parametric linearization technique
Authors: Tang Shuai , Chen Yuzhen , Guo Yunrui 
Published: November 2018

AbstractIn this paper, we present an effective algorithm for globally solving quadratic programs with quadratic constraints, which has wide application in engineering design, engineering optimization, route optimization, etc. By utilizing new parametric linearization technique, we can derive the parametric linear programming relaxation problem of the quadratic programs with quadratic constraints. To improve the computational speed of the proposed algorithm, some interval reduction operations are used to compress the investigated interval. By subsequently partitioning the initial box and solving a sequence of parametric linear programming relaxation problems the proposed algorithm is convergent to the global optimal solution of the initial problem. Finally, compared with some known algorithms, numerical experimental results demonstrate that the proposed algorithm has higher computational efficiency.
Posttraumatic stress and autobiographical memory in chronic pain patients
Authors: Siqveland Johan , Hauff Edvard , Ruud Torleif , Brennen Timothy J. 
Published: November 2018

Abstract

Background and aims
Posttraumatic stress disorder (PTSD) is related to more severe pain among chronic pain patients. PTSD is also related to dysfunctions or biases in several cognitive processes, including autobiographical memory. The autobiographical memories are our memories of specific personal events taking place over a limited amount of time on a specific occasion. We investigated how two biases in autobiographical memory, overgeneral memory style and negative emotional bias were related to pain, PTSD and trauma exposure in chronic pain patients.

Methods
Forty-three patients with diverse chronic pain conditions were recruited from a specialist pain clinic. The patients were evaluated for psychiatric diagnosis, with a diagnostic interview Mini-International Neuropsychiatric Interview (M.I.N.I) and for exposure to the most common types of traumatic events with the Life Event Checklist (LEC). The patients were tested with the 15-cue-words version of the Autobiographical Memory Test (AMT). In this test the participants are presented verbally to five positive, five neutral and five negative cue words and asked to respond with a personal, episodic memory associated with the cue word. The participant’s responses were coded according to level of specificity and emotional valence. Pain intensity was assessed on a Visual Analogy Scale (VAS) and extent of pain by marking affected body parts on a pre-drawn body figure. Comparisons on autobiographical memory were made between PTSD and non-PTSD groups, and correlations were computed between pain intensity and extent of pain, trauma exposure and autobiographical memory.

Results
PTSD and extent of pain were significantly related to more negatively emotionally valenced memory responses to positive and negative cue words. There were no significant difference in response to neutral cue words. PTSD status and pain intensity were unrelated to overgeneral autobiographical memory style.

Conclusions
A memory bias towards negatively emotionally valenced memories is associated with PTSD and extent of pain. This bias may sustain negative mood and thereby intensify pain perception, or pain may also cause this memory bias. Contrary to our expectations, pain, trauma exposure and PTSD were not significantly related to an overgeneral memory style.

Implications
Cognitive therapies that have an ingredient focusing on amending memory biases in persons with comorbid pain and PTSD might be helpful for this patient population. Further investigations of negative personal memories and techniques to improve the control over these memories could potentially be useful for chronic pain treatment.
Orthorhombic sulfur from Cap Garonne, Mine du Pradet
Authors: Kösters Jutta , Galéa-Clolus Valérie , Clolus Pierre , Heying Birgit , Pöttgen Rainer 
Published: November 2018

Abstract
Natural orthorhombic sulfur (α-S8), grown on galena crystals from Cap Garonne, Mine du Pradet, France, were studied by single crystal X-ray diffraction at 150 K: Fddd, a=1036.75(5), b=1273.54(7), c=2437.85(13) pm, wR=0.0380, 1433 F
2 values (all data) and 37 variables. Refinements of the occupancy parameters along with EDX data indicate pure sulfur.
Molecular Interaction of Hemorrheologic Agent, Pentoxifylline with Bovine Serum Albumin: An Approach to Investigate the Drug Protein Interaction Using multispectroscopic, Voltammetry and Molecular Modelling Techniques
Authors: Mallappa Mahanthappa , Savanur Mohammed Azharuddin , Gowda Babu Giriya , Vishwanth R.S. , Puthusseri Bijesh 
Published: November 2018

AbstractThe interaction between pentoxifylline (PTX) and bovine serum albumin (BSA) was studied under physiological condition by spectroscopic, voltammetry and molecular modelling techniques. The results of fluorescence studies revealed that the quenching mechanism of BSA by PTX was a static procedure. Binding constant of PTX-BSA was calculated and its value found to be 8.895 × 104M−1, which is in close agreement with the results obtained from UV-Visible and voltammetry approach. The negative values of thermodynamic parameters (ΔG, ΔH and ΔS) indicated that van der Waals force and hydrogen bonding play major roles in the interaction of PTX with BSA. Based on Forster’s theory of non-radiation energy transfer, the binding distance (r) between the donor (BSA) and acceptor (PTX) was found to be 5.38 nm (298 K). The results of UV-Visible and circular dichroism (CD) spectroscopy showed that PTX interacts with BSA and induces conformational changes by reducing theα-helix content. The results of the UV-visible and voltammetry studies were further verified by the molecular docking method. Molecular modelling studies revealed possible residues involved in the drug-protein interaction and indicated that PTX binds to Site IIA of BSA.
Hermann Suchier (1848–1914) und Gaston Paris (1839–1903): «Monsieur» oder «Mon cher ami»?
Authors: Hausmann Frank-Rutger 
Published: November 2018

Abstract
Hermann Suchier, since the year 1876 Professor of Romance Philology at the University of Halle, was one of the most prominent scholars of his generation. Since he preserved all his correspondence, we are able to study his various international written relationships with his French colleagues, including Gaston Paris and Paul Meyer. However, a temporary disagreement between Suchier with Paris and Meyer did arise. This conflict was due to Suchier supporting the work of Wendelin Foerster, whose edition of Aiol et Mirabel was severely criticized by Paris and Meyer. Subsequently, Suchier once again changed support back to Paris and Meyer and then was invited to publish in their house journal, Romania, and additionally to contribute two editions in ancient French to the Société des Anciens Textes Français which had also be founded by Paris and Meyer. In this way Suchier became one of the most important intermediaries between German and French Philology in the years following the Franco-German war and the outbreak of World War I.
Pervasive Positive and Negative Feedback Regulation of Insulin-Like Signaling inCaenorhabditis elegans
Authors: Kaplan Rebecca E W , Maxwell Colin S , Codd Nicole Kurhanewicz , Baugh L Ryan 
Published: November 2018

AbstractThe Caenorhabditis elegans genome encodes 40 insulin-like peptides, but the dynamics of insulin signaling both during development and in response to nutrient availability is not well understood. Kaplan and Maxwell et al. report that transcription of....The Caenorhabditis elegans insulin-like signaling network supports homeostasis and developmental plasticity. The genome encodes 40 insulin-like peptides and one known receptor. Feedback regulation has been reported, but the extent of feedback and its effect on signaling dynamics in response to changes in nutrient availability has not been determined. We measured messenger RNA expression for each insulin-like peptide, the receptor daf-2, components of the PI3K pathway, and its transcriptional effectors daf-16/FoxO and skn-1/Nrf at high temporal resolution during transition from a starved, quiescent state to a fed, growing state in wild type and mutants affecting daf-2/InsR and daf-16/FoxO. We also analyzed the effect of temperature on insulin-like gene expression. We found that most PI3K pathway components and insulin-like peptides are affected by signaling activity, revealing pervasive positive and negative feedback regulation at intra- and intercellular levels. Reporter gene analysis demonstrated that the daf-2/InsR agonist daf-28 positively regulates its own transcription and that the putative agonist ins-6 cross-regulates DAF-28 protein expression through feedback. Our results show that positive and negative feedback regulation of insulin-like signaling is widespread, giving rise to an organismal FoxO-to-FoxO signaling network that supports homeostasis during fluctuations in nutrient availability.
Classification of Encouragement (Targhib) And Warning (Tarhib) Using Sentiment Analysis on Classical Arabic
Authors: AlHasani Hatem , Saad Saidah , Kassim Junaidah 
Published: November 2018

The Holy Qur’an is the main religious text of Islam. The Qur’an has its own methods of Targhib (encouragement) and Tarhib (warning), which are important features of the Qur’an. Most of the Quranic verses would urge and encourage people to do right and good deeds, and also warn them from committing evil and bad deeds. The method of classifying a text into two opposing opinions has been applied previously in solving the problem of sentiment analysis. Currently, it is applied in identifying between Targhib (encouragement) and Tarhib (warning) verses in the Qur’an. Each verse of the Qur’an can be treated as either an encouragement, warning or neutral. The language of the Holy Qur’an is one of the most challenging natural languages in sentiment analysis. The aim of this work is to classify the verses of encouragement and warning using sentiment analysis and NLP techniques. Several approaches are used in the Sentiment Analysis classification, such as the machine learning approach, the lexicon-based approach and the hybrid approach. In carrying out this aim, the applied machine learning approach was used, where the impact of the use of different techniques such as POS tagging, N-Gram and Feature selection with correlation based were evaluated and investigated. 95.6% accuracy was achieved using Naí¯ve Bayes (NB) and 91.5% accuracy was achieved using the Support Vector Machines (SVM). This study is a significant study in extracting information and knowledge from the Holy Qur’an. It is significant for both researchers in the field of Islamic studies as well as non-specialized researchers.
Sensory and Physical Properties of Pla-duk-ra (Dried Fermented Catfish) at Different Conditions of Drying
Authors: Azhani Siti , Hniman Adilan , Laehmad Nattaya , Hanifarianty Sherly , Masniyom Payap , Noipom Tawat , Wae-hayee Makatar 
Published: November 2018

In southernmost Thailand, big scale production of catfish demands a development of new lines of catfish-based products to fully utilize the raw material. Pla-duk-ra (dried fermented catfish) is one such innovation. Traditional method of sunlight drying is commonly used to dry Pla-duk-ra. However, products are highly prone to contamination since they are dried in exposed area. Direct exposure to sunlight could also affect heat labile and light-sensitive nutrients. In this study, other methods of drying were investigated to dry Pla-duk-ra with improved hygiene practice, physical properties and sensory profile. Two scenarios were studied in this work. The objective of the first scenario was to determine the best range of temperature to dry a good and acceptable Pla-duk-ra by comparing open sun drying (range 40ËšC to 50ËšC) and shade drying (under the roof; 30ËšC to 40ËšC) . The best range of temperature obtained was then used for the second scenario where open sun, infrared and tray drying were further studied. Moisture content, water activity, colour, texture profile analysis were performed on the Pla-duk-ra samples. Fried Pla-duk-ra was used in sensory evaluation to investigate consumer’s acceptance and preference. Open sun drying was found to be more superior to dry Pla-duk-ra resulting in darker shade of product as compared to shade drying. The moisture content for open sun drying and shade drying of Pla-duk-ra were reported 23.65% and 28.06%, respectively. Infrared heater gave the highest water activity (0.77) with the highest score for redness. Meanwhile, Pla-duk-ra dried under the hot-air tray resulted in the highest score for brightness (L*). Overall acceptance by the consumer showed that the Pla-duk-ra dried under the hot-air tray was the most preferred followed by open sun drying and infrared heater drying. To this end, hot-air tray drying could be applied in drying Pla-duk-ra in large scale production.
Cutout Types Analysis on Picohydro Pelton Turbine
Authors: Budiarso - , Warjito - , Adanta Dendy , Putra Nesen Syah , Vohra Hans 
Published: November 2018

Pico hydro is a simple electricity generation technology and can be applied in remote areas that do not have access to electricity. Pico hydro systems produce power less than or equal to 5 kW. Pelton turbine is an impulse turbine frequently used in a pico hydro system. Pelton turbine has a cut-out in its buckets that prevent the water jet leak from the tip of the bucket into the next bucket. The study has been done to explain the effects of bucket geometry on energy conversion from water flow into kinetic energy. Four different types of cutouts namely Ï‰, v, w and u were used. This study aims to find the best cutout geometry, which can convert the most water energy. The computation method is utilized to study in detail the flow of the fluid. In this study, there is two principal analysis performed, first is ANOVA blocking design for torque analysis, and the second is a qualitative analysis of the flow passing the cutout. The results indicate that the cutouts of the buckets have a significant influence on generated torque. The analysis revealed that u type cut-out buckets give the best performance among others type of buckets and are the easiest to manufacture.
The Effect of Gamma Radiation on Plant Morphological Characteristics of Zingiber officinale Roscoe
Authors: Abdullah Shamsiah , Kamaruddin Nor Yusliza , Harun Abdul Rahim 
Published: November 2018

Induced mutation through gamma irradiation can cause changes in chromosome and genome which bring to successful variation in morphology of plant. The study was carried out to investigate the effect of gamma radiation on mutation frequency and plant morphology of Zingiber officinale Roscoe. The ginger rhizomes of Bentong and Tanjung Sepat cultivars were treated with gamma rays at six different dosages (5, 7, 9, 11, 13 and 15 Gray). The gamma ray was emitted from the Caesium-137 source at the rate of 4.31 Gy per minute at Malaysian Nuclear Agency irradiator facility. Different mutation frequencies and wide of mutation spectrum were observed in all treatments. The spectrums of mutant characters observed were stunted growth, plant stature, leaf deformation and chlorophyll mutation. The results show that mutation frequency in both varieties was higher at 5 and 7 Gy when compared to other doses. Therefore, the results proved that different doses of mutagen caused different effects on plant.
Developing the Dimensions of a Social Content Management Framework
Authors: Wan Ahmad Wan Azlin Zurita , Mukhtar Muriati , Yahya Yazrina 
Published: November 2018

The rise of social media has transformed the way of collaboration between organisations and customers. Social content resulting from the active collaboration between both parties on a social media platform should be managed accordingly. Thus, a social content management (SCM) framework should be developed as a guide to manage the social content. Such SCM framework should be able to augment existing frameworks, which mainly focuses on the value of social content for the organisations. Hence, based on the service science perspective, this article proposes a SCM framework that focusses on value to both organisations and its customers. In order to do this, the concept of Service Dominant Logic and the DART model are adopted to explore and extract the elements and factors that collectively become the dimensions of the proposed SCM framework. Experts’ review of the elements and factors is conducted to ensure that the dimensions in the SCM framework are acceptable and have practical value. The proposed framework is then validated via an instrument whose content validity is investigated by using Lawshe’s Technique. This framework could assist the organisations in decision-making process towards innovating services and in the management of social content.