bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability Analysis of a Bulk-Surface Reaction Model for Membrane-Protein Clustering
Authors: Stolerman Lucas M. , Getz Michael , Llewellyn Smith Stefan G. , Holst Michael , Rangamani Padmini 
Published: August 2019

ABSTRACTProtein aggregation on the plasma membrane (PM) is of critical importance to many cellular processes such as cell adhesion, endocytosis, fibrillar conformation, and vesicle transport. Lateral diffusion of protein aggregates or clusters on the surface of the PM plays an important role in governing their heterogeneous surface distribution. However, the stability behavior of the surface distribution of protein aggregates remains poorly understood. Therefore, understanding the spatial patterns that can emerge on the PM solely through protein-protein interaction, lateral diffusion, and feedback is an important step towards a complete description of the mechanisms behind protein clustering on the cell surface. In this work, we investigate the pattern formation of a reaction-diffusion model that describes the dynamics of a system of ligand-receptor complexes. The purely diffusive ligand in the cytosol can bind receptors in the PM, and the resultant ligand-receptor complexes not only diffuse laterally but can also form clusters resulting in different oligomers. Finally, the largest oligomers recruit ligands from the cytosol in a positive feedback. From a methodological viewpoint, we provide theoretical estimates for diffusion-driven instabilities of the protein aggregates based on the Turing mechanism. Our main result is a threshold phenomenon, in which a sufficiently high recruitment of ligands promotes the input of new monomeric components and consequently drives the formation of a single-patch spatially heterogeneous steady-state.
Drought sensitivity of leaflet growth, biomass accumulation, and resource partitioning predicts yield in common bean
Authors: Hageman Amber , Urban Milan O. , Van Volkenburgh Elizabeth 
Published: August 2019

ABSTRACTWhile drought limits yield largely by its impact on photosynthesis and therefore biomass accumulation, biomass is not the strongest predictor of yield under drought. Instead, resource partitioning efficiency, measured by how much total pod weight is contained in seeds at maturity (Pod Harvest Index), is the stronger correlate in Phaseolus vulgaris. Using 20 field-grown genotypes, we expanded on this finding by pairing yield and resource partitioning data with growth rates of leaflets and pods. We hypothesized that genotypes which decreased partitioning and yield most under drought would also have strongest decreases in growth rates. We found that while neither leaflet nor pod growth rates correlated with seed yield or partitioning, impacts to leaflet growth rates under drought correlate with impacts to yield and partitioning. As expected, biomass production correlated with yield, yet correlations between the decreases to these two traits under drought were even stronger. This suggests that while biomass contributes to yield, biomass sensitivity to drought is a stronger predictor. Lastly, under drought, genotypes may achieve similar canopy biomass yet different yields, which can be explained by higher or lower partitioning efficiencies. Our findings suggest that inherent sensitivity to drought may be used as a predictor of yield.HIGHLIGHTIn common bean, higher biomass accumulation under drought alone does not guarantee higher yield, as maintenance of higher growth rates and partitioning processes act as an additional requirement.
Genome-wide analysis of transcriptional bursting-induced noise in mammalian cells
Authors: Ochiai Hiroshi , Hayashi Tetsutaro , Umeda Mana , Yoshimura Mika , Harada Akihito , Shimizu Yukiko , Nakano Kenta , Saitoh Noriko , Kimura Hiroshi , Liu Zhe , Yamamoto Takashi , Okamura Tadashi , Ohkawa Yasuyuki , Nikaido Itoshi 
Published: August 2019

AbstractTranscriptional bursting is stochastic activation and inactivation of promoters, leading to discontinuous production of mRNA, and is considered to be a contributing factor to cell-to-cell heterogeneity in gene expression. However, it remains elusive how the kinetic properties of transcriptional bursting (e.g., burst size, burst frequency, and noise induced by transcriptional bursting) are regulated in mammalian cells. In this study, we performed a genome-wide analysis of transcriptional bursting in mouse embryonic stem cells (mESCs) using single-cell RNA-sequencing. We found that the kinetics of transcriptional bursting was determined by a combination of promoter and gene body binding proteins, including polycomb repressive complex 2 and transcription elongation-related factors. Furthermore, large-scale CRISPR-Cas9-based screening and functional analysis revealed that the Akt/MAPK signaling pathway regulated bursting kinetics by modulating transcription elongation efficiency. These results uncover key molecular mechanisms underlying transcriptional bursting and cell-to-cell gene expression noise in mammalian cells.
Emodin Attenuates Renal Interstitial Fibrosis via Regulation of TIMP1/MM9 Pathway in Rats
Authors: Li Dongmei , Zhang Qingchuan , Lou Yujiao , He Chunfeng , Gu Renze , Liu Wei 
Published: August 2019

AbstractEmodin has a variety of pharmacological functions including anti-bacterial infection, anti-inflammatory, anti-oxidation, anti-tumor, regulation of gastrointestinal activities and anti-hepatic and lung fibrosis. However, the role of emodin in the regulation of renal interstitial fibrosis(RIF) remains poorly understood. In this study, we investigated the regulation of emodin in RIF and revealed the underlying molecular mechanisms. We established a unilateral ureter obstruction(UUO) model to simulate renal interstitial fibrosis in rats. We found that UUO rats were observed a large amount of inflammatory cell infiltration, more fibroblast proliferation, collagen fiber proliferation. Furthermore, we demonstrated that the up-regulation of TIMP1 and down-regulation of MMP9 were related to renal fibrosis. However, those phenomena in emodin-treated UUO rats were ameliorated. Collectively, our results provide new insights into the treatment of RIF and suggest that the TIMP1/MM9 signaling axis may be a potential therapeutic target for RIF.
Synthesis and crystal structure of 1,3-bis(4-hydroxyphenyl)-1H-imidazol-3-ium chloride
Authors: Mertens R. Tyler , Parkin Sean R. , Awuah Samuel G. 
Published: August 2019

Imidazolium salts are common building blocks for functional materials and in the synthesis of N-heterocyclic carbene (NHC) as σ-donor ligands for stable metal complexes. The title salt, 1,3-bis(4-hydroxyphenyl)-1H-imidazol-3-ium chloride (IOH·Cl), C15H13N2O2+·Cl−, is a new imidazolium salt with a hydroxy functionality. The synthesis of IOH·Cl was achieved in high yieldviaa two-step procedure involving a diazabutadiene precursor followed by ring closure using trimethylchlorosilane and paraformaldehyde. The structure of IOH·Cl consists of a central planar imidazolium ring (r.m.s. deviation = 0.0015 Å), with out-of-plane phenolic side arms. The dihedral angles between the 4-hydroxyphenyl substituents and the imidazole ring are 55.27 (7) and 48.85 (11)°. In the crystal, O—H...Cl hydrogen bonds connect the distal hydroxy groups and Cl−anions in adjacent asymmetric units, one related by inversion (−x + 1, −y + 1, −z + 1) and one by then-glide (x − {1\over 2}, −y + {1\over 2},z − {1\over 2}), with donor–acceptor distances of 2.977 (2) and 3.0130 (18) Å, respectively. The phenolic rings are each π–π stacked with their respective inversion-related [(−x + 1, −y + 1, −z + 1) and (−x, −y + 1, −z + 1)] counterparts, with interplanar distances of 3.560 (3) and 3.778 (3) Å. The only other noteworthy intermolecular interaction is an O...O (not hydrogen bonded) close contact of 2.999 (3) Å between crystallographically different hydroxy O atoms on translationally adjacent molecules (x + 1,y,x + 1).
Blade stacking and clocking effects in two-stage high-pressure axial turbine
Authors: Touil Kaddour , Ghenaiet Adel 
Published: August 2019

Purpose
The purpose of this paper is to characterize the blade–row interaction and investigate the effects of axial spacing and clocking in a two-stage high-pressure axial turbine.

Design/methodology/approach
Flow simulations were performed by means of Ansys-CFX code. First, the effects of blade–row stacking on the expansion performance were investigated by considering the stage interface. Second the axial spacing and the clocking positions between successive blade–rows were varied, the flow field considering the frozen interface was solved, and the flow interaction was assessed.

Findings
The axial spacing seems affecting the turbine isentropic efficiency in both design and off-design operating conditions. Besides, there are differences in aerodynamic loading and isentropic efficiency between the maximum efficiency clocking positions where the wakes of the first-stage vanes impinge around the leading edge of the second-stage vanes, compared to the clocking position of minimum efficiency where the ingested wakes pass halfway of the second-stage vanes.

Research limitations/implications
Research implications include understanding the effects of stacking, axial spacing and clocking in axial turbine stages, improving the expansion properties by determining the adequate spacing and locating the leading edge of vanes and blades in both first and second stages with respect to the maximum efficiency clocking positions.

Practical implications
Practical implications include improving the aerodynamic design of high-pressure axial turbine stages.

Originality/value
The expansion process in a two-stage high-pressure axial turbine and the effects of blade–row spacing and clocking are elucidated thoroughly.
Talent management research in Africa: towards multilevel model and research agenda
Authors: Anlesinya Alex , Amponsah-Tawiah Kwesi , Dartey-Baah Kwasi 
Published: August 2019

Purpose
The purpose of this paper is to systematically review talent management research in Africa with the aim of developing a multilevel talent management model and defining future research agenda.

Design/methodology/approach
A systematic literature review is performed utilising studies published on the topic from 2008 to 2019 in various research databases.

Findings
The findings highlighted various talent management contributions and challenges in the African context. They further revealed major issues with the nature of research method adopted in talent management research in Africa. Moreover, contextually, apart from Southern Africa sub-region, talent management research is highly under-researched in the North African, West African and Eastern African sub-regions of the continent. Therefore, talent management research in Africa can be described as being at an embryonic stage.

Practical implications
Effective talent management has significant transformative and growth power through its varied positive contributions. Talent management in Africa is faced with numerous organisational and macro-level challenges and requires attention from relevant stakeholders, if African talents are to be harnessed to facilitate the development of the continent.

Originality/value
This systematic review on talent management is the first of its kind focusing solely on Africa. Also, this study contributes further evidence by proposing a multilevel talent management model based on the synthesised evidence since multilevel research in the field of talent management is very limited.
Farmer preference for swine price index insurance
Authors: Zhang Yanyuan , Hu Wuyang , Zhan Jintao , Chen Chao 
Published: August 2019

Purpose
The purpose of this paper is to examine farmer preference for swine price index insurance in China focusing on whether Chinese farmers are willing to consider purchasing swine price index insurance, the premium they would like to pay, as well as the extend of heterogeneity in their preferences.

Design/methodology/approach
A sample of 443 swine farmers in Jiangsu and Henan provinces is collected and analyzed. An Ordered Probit model is used to analyze farmers’ willingness to buy swine price index insurance and a Tobit model is used to analyze farmers’ willingness to pay (WTP) for insurance premium.

Findings
Results show that some farmers are not willing to purchase swine price index insurance. However, WTP of majority of farmers is higher than what is prescribed in the current insurance policy. Factors affecting farmers’ willingness to buy varied between two provinces. Experience in purchasing traditional swine insurance and risk perception affect farmers’ willingness to buy in Jiangsu province, while joining agricultural cooperatives, experience in purchasing traditional swine insurance and understanding of swine price index insurance affect farmers’ willingness to buy in Henan province. Farmers with non-agricultural income, longer years of swine breeding, higher degree of specialization, experience in purchasing traditional insurance, higher understanding of swine price index insurance and trust in local governments, stronger risk perception and risk preference, and not being a member of agricultural cooperatives have higher WTP.

Originality/value
Few studies have been conducted on swine price index insurance in China. Even less information, to the authors’ knowledge, is available on farmer preferences. The research provides a timely contribution to understand the Chinese swine price index insurance market from the perspectives of farmers.
Economic validity analysis of housing reverse mortgages in China
Authors: Han Wei , Jiang Yushi 
Published: August 2019

Purpose
The purpose of this paper is to empirically analyze the investment and pension functions of housing reverse mortgages (HRM) with redemption option and raise the participation initiative of the Chinese elderly for the HRM model and enhance their cognition of this financial product.

Design/methodology/approach
Based on the perspective of the financial decisions of the elderly, this study designs an analysis model of the economic validity of HRM, and takes Shanghai (a pilot city for HRM loans in China) as an example, using data from the Shanghai real-estate index and market interest rates from January 1998 to December 2018, as well as the contract data of HRM, for empirical analysis.

Findings
The results show that the HRM with redemption option has the characteristics of European call option and can obtain the value of implicit option from the perspective of the elderly. Considering the present value of the accumulated pension income, the present value of the redemption option and the present value of the final housing value, the elderly can obtain investment income from HRM with redemption option. Therefore, for Chinese seniors, the HRM with redemption option has economic validity.

Research limitations/implications
From the perspective of the demand of the elderly, participation in the HRM with redemption option can increase the life expectancy annuity for various pension expenditures and improve economic status while meeting the demand of inheritance motivation.

Practical implications
This study helps to clarify the financial decision-making process for elderly people who participate in HRM. On the one hand, it helps policy makers to optimize the implementation mode of HRM and promote the healthy and rapid development of HRM; on the other hand, it is conducive to raising the awareness of Chinese elderly people on this financial products and enhancing their enthusiasm for participating in HRM.

Originality/value
Few studies have directly analyzed the financial decision process of the HRM model from the perspective of the demand of the elderly. This study enriches the research viewpoint and method of HRM and accumulates data about the Chinese experience with HRM.
Hybrid nanofluid flow and heat transfer past a vertical thin needle with prescribed surface heat flux
Authors: Waini Iskandar , Ishak Anuar , Pop Ioan 
Published: August 2019

Purpose
The purpose of this paper is to study the steady mixed convection hybrid nanofluid flow and heat transfer past a vertical thin needle with prescribed surface heat flux.

Design/methodology/approach
The governing partial differential equations are transformed into a set of ordinary differential equations by using a similarity transformation. The transformed equations are then solved numerically using the boundary value problem solver (bvp4c) in Matlab software. The features of the skin friction coefficient and the local Nusselt number as well as the velocity and temperature profiles for different values of the governing parameters are analyzed and discussed.

Findings
It is found that dual solutions exist for a certain range of the mixed convection parameter where its critical values decrease with the increasing of the copper (Cu) nanoparticle volume fractions and for the smaller needle size. It is also observed that the increasing of the copper (Cu) nanoparticle volume fractions and the decreasing of the needle size tend to enhance the skin friction coefficient and the local Nusselt number on the needle surface. A temporal stability analysis is performed to determine the stability of the dual solutions in the long run, and it is revealed that only one of them is stable, while the other is unstable.

Originality/value
The problem of hybrid nanofluid flow and heat transfer past a vertical thin needle with prescribed surface heat flux is the important originality of the present study where the dual solutions for the opposing flow are obtained.
A novel model of plane waves of two-temperature fiber-reinforced thermoelastic medium under the effect of gravity with three-phase-lag model
Authors: Othman Mohamed I.A. , Said Samia , Marin Marin 
Published: August 2019

Purpose
In the present paper, the three-phase-lag (3PHL) model, Green-Naghdi theory without energy dissipation (G-N II) and Green-Naghdi theory with energy dissipation (G-N III) are used to study the influence of the gravity field on a two-temperature fiber-reinforced thermoelastic medium.

Design/methodology/approach
The analytical expressions for the displacement components, the force stresses, the thermodynamic temperature and the conductive temperature are obtained in the physical domain by using normal mode analysis.

Findings
The variations of the considered variables with the horizontal distance are illustrated graphically. Some comparisons of the thermo-physical quantities are shown in the figures to study the effect of the gravity, the two-temperature parameter and the reinforcement. Also, the effect of time on the physical fields is observed.

Originality/value
To the best of the author’s knowledge, this model is a novel model of plane waves of two-temperature fiber-reinforced thermoelastic medium, and gravity plays an important role in the wave propagation of the field quantities. It explains that there are significant differences in the field quantities under the G-N II theory, the G-N III theory and the 3PHL model because of the phase-lag of temperature gradient and the phase-lag of heat flux.
Natural convection heat transfer of nanofluid inside a cavity containing rough elements using lattice Boltzmann method
Authors: Mohebbi Rasul , Izadi Mohsen , Che Sidik Nor Azwadi , Najafi Gholamhassan 
Published: August 2019

Purpose
This paper aims to study the natural convection of a nanofluid inside a cavity which contains obstacles using lattice Boltzmann method (LBM). The results have focused mainly on various parameters such as number and aspect ratio of roughness elements and different nanoparticle volume fraction. The isotherms and streamlines are presented to describe the hydrodynamics and thermal behaviors of the nanofluid flow throughout the enclosure.

Design/methodology/approach
The methodology of this paper consists of mathematical model, statement of the problem, nanofluid thermophysical properties, lattice Boltzmann method, LBM for fluid flow, LBM for heat transfer, numerical strategy, boundary conditions, Nusselt (Nu) number calculation, code validation and grid independence.

Findings
Natural convection heat transfers of a nanofluid inside cavities with and without rough elements have been studied. Lattice Boltzmann technique has been used as numerical approach. The results showed that at higher Rayleigh number (Ra = 106), there are denser streamlines near the left (source) and right wall (sink) which results in better cooling and enhances convective heat rejection to the heat sink. After a distinctive aspect ratio of rough elements (A = 0.1), change in streamline pattern which arises from increasing of aspect ratio does not have an important effect on isotherms. Results indicate that for lower Rayleigh number (Ra = 103), no variation in average Nu is observed with increasing in number of roughness, while for higher one (Ra = 106) average Nu decreases from N = 0 (smooth cavity) up to N = 4 and then remains constant (N = 6).

Originality/value
Currently, no argumentative and comprehensive extraction can be concluded without fully understanding the role of different arrangement of roughness. Some geometrical parameters such as aspect ratio, number and position of rough elements have been considered. Also, the effect of nanoparticle concentration was studied at different Ra number. Briefly, using LBM, this paper aims to investigate the natural convection of a nanofluid flow on the thermal and hydrodynamics parameters in the presence of rough element with various arrangements.
Analysis of dusty Casson fluid flow past a permeable stretching sheet bearing power law temperature and magnetic field
Authors: Hasnain Jafar , Abbas Zaheer , Sheikh Mariam , Aly Shaban 
Published: August 2019

Purpose
This study aims to present an analysis on heat transfer attributes of fluid-particle interaction over a permeable elastic sheet. The fluid streaming on the sheet is Casson fluid (CF) with uniform distribution of dust particles.

Design/methodology/approach
The basic steady equations of the CF and dust phases are in the form of partial differential equations (PDEs) which are remodeled into ordinary ones with the aid of similarity transformations. In addition to analytical solution, numerical solution is obtained for the reduced coupled non-linear ordinary differential equations (ODEs) to validate the results.

Findings
The solution seems to be influenced by significant physical parameters such as CF parameter, magnetic parameter, suction parameter, fluid particle interaction parameter, Prandtl number, Eckert number and number density. The impact of these parameters on flow field and temperature for both fluid and dust phases is presented in the form of graphs and discussed in detail. The effect on skin friction coefficient and heat transfer rate is also presented in tabular form. It has been observed that an increase in the CF parameter curtails the fluid velocity as well as the particle velocity however enhances the heat transfer rate at the wall. Furthermore, comparison of the numerical and analytical solution is also made and found to be in excellent agreement.

Originality/value
Although the analysis of dusty fluid flow has been widely examined, however, the present study obtained both analytical and numerical results of power law temperature distribution in dusty Casson fluid under the influence of magnetic field which are new and original for such type of flow.