bluuebunny/crossref_metadata_2025_split huggingface dataset:
Docetaxel, Oxaliplatin, and 5-Fluorouracil (DOF) in Metastatic and Unresectable Gastric/Gastroesophageal Junction Adenocarcinoma: A Phase II Study with Long-Term Follow-Up
Authors: Rosenberg Ari Joseph , Rademaker Alfred , Hochster Howard S. , Ryan Theresa , Hensing Thomas , Shankaran Veena , Baddi Lisa , Mahalingam Devalingam , Mulcahy Mary F. , Benson Al B. 
Published: May 2019

Abstract

Lessons Learned
Adding docetaxel to the modified FOLFOX7 backbone (DOF) is a feasible three-drug combination therapy for advanced gastric cancer with high activity, providing evidence that leucovorin is not necessary in this setting. The DOF regimen represents an alternative to the FLOT (5-FU 2,600 mg/m2 as 24-hour infusion with leucovorin 200 mg/m2, oxaliplatin 85 mg/m2, and docetaxel 50 mg/m2) regimen that can be considered in select patients with advanced gastric cancer and is a potential choice in the curative setting.

Background
The combination of docetaxel, cisplatin, and 5-fluorouracil (5-FU) demonstrates high response rates in advanced gastric cancer, albeit with increased toxicity. Given the efficacy of platinum-taxane-fluoropyrimidine regimens, this phase II study evaluated the efficacy and toxicity of docetaxel, oxaliplatin, and 5-FU (DOF) for the treatment of metastatic or unresectable gastric or gastroesophageal junction (GEJ) adenocarcinoma.

Methods
Patients with metastatic or unresectable gastric or GEJ adenocarcinoma with no prior therapy for metastatic disease received docetaxel 50 mg/m2 on day 1, oxaliplatin 85 mg/m2 on day 1, and 5-FU 2,400 mg/m2 continuous intravenous infusion over 46 hours; cycles were repeated every 2 weeks. The primary endpoint was overall response rate (ORR).

Results
Forty-four patients were enrolled. Assessment of treatment response and toxicity was feasible in 41 and 43 patients, respectively. ORR was 73.2% (68.3% partial response; 4.9% complete response). Therapy was discontinued for progressive disease in 53%, toxicity in 26%, and death on treatment in 16%. Two patients underwent surgical resection. Thirty-three patients (76.7%) received at least seven cycles (7–34). Grade 3–4 toxicities occurred in 31 patients (72.1%), including neutropenia (23.3%), neurologic (20.9%), and diarrhea (14.0%). Median overall survival was 10.3 months.

Conclusion
DOF demonstrates a high response rate, expected safety profile, and prolonged survival and remains an option for select patients with unresectable or metastatic gastric or GEJ adenocarcinoma.
Unmanned Aerial Vehicles as a Segment of Digital Technologies in the Criminal and Post-Criminal Reality
Authors: Vardanyan Akop , Andreev Alexandr 
Published: May 2019

Changes in technologies and the transition to the digital format are evident in all spheres of society, they are altering not only the criminal and post-criminal reality, but also the system of law enforcement bodies’ work. One of such segments of digital techniques and technologies with a multidisciplinary significance is unmanned areal vehicles (UAVs). Public disputes regarding the legal regulation of the use of UAVs are becoming more heated in the era of transition to digital technologies. The object of research is UAVs and related processes in the legal sphere in Russia and abroad, the studied aspect is the regularities of the criminal and post-criminal reality. Although there is no official statistical data on the number of registered reports on illegal use of UAVs, for the purposes of this article the authors have identified and studied over one thousand such incidents in the Russian legal field. The authors present the basic part of their forecast for the criminal and post-criminal reality and the use of UAVs (tactical and strategic aspects). The paper predicts the emergence of new phenomena, processes, events and situations caused by the consequences of integrating UAVs in the criminal and post-criminal reality of Russia and other countries. The controversy of such processes is predetermined by the opposing types of human activities recognized by researchers of criminalistics: in the first case, it is criminal activities (crimes), and in the second — anti-crime work of the state (detection and investigation of crimes, and in some cases — court proceedings). The analysis of the use of UAVs by the law enforcement bodies has revealed a number of systemic, organizational, legal and methodological problems and drawbacks. The authors present their conclusions regarding the patterns in the use of UAVs in criminal and post-criminal situations, outline key problems of the research support of law enforcement activities involving UAVs and ways of solving them.
Doctor of Law, Professor Nikolai Ignatyevich Trofimov: the Scientific Legacy of the Researcher
Authors: Kazarin Victor , Kravtsov Roman , Arkhipkin Igor 
Published: May 2019

The article is dedicated to the memory of a famous scientist and teacher, Doctor of Law, Professor N.I. Trofimov, who would have turned 90 years old in 2018. A native Siberian born in a peasant family, he transitioned from a school teacher to a Doctor of Law, Professor, Dean of the Law Faculty of Irkutsk State University and Head of the Chair of Criminal Law. He successfully defended his Ph.D. thesis, and later his doctoral dissertation at M.V. Lomonosov Moscow State University. N.I. Trofimov had been engaged in research and teaching for over 40 years, he read courses of Criminal Law, Criminology and special courses. His numerous articles and monographs, reviews and textbooks were devoted to topical problems, mainly, the criminal and legal protection of the mental and physical development of minors. He researched such topics as the general concept of crime against the normal development of minors, encroachments on the development of minors, including their involvement in criminal and other anti-social activities, sexual abuse, coercion to common law marriage of persons under the marriageable age; he analyzed data on the identity of convicts and victims in cases of non-violent sexual crimes against minors. N.I. Trofimov responded promptly to important social and political events in the life of the country, giving them a legal assessment, and made proposals for improving criminal legislation. He is the author and contributing author of about 100 research, methodological and educational publications. He proved himself to be an experienced administrator who made a great contribution to the development of higher legal education in Eastern Siberia. The study of key problems of criminal law and criminology, started by N.I. Trofimov, has been continued by modern Russian and foreign researchers.
Effect of duration of pre-operative admission on surgical site infection in major abdominal surgeries: an observational study
Authors: Gupta Alka Shantiprakash , Shetty Arthika 
Published: May 2019

Background: Surgical site infection (SSI) are second most common cause of mortality in surgical patient, situation has been further complicated by emergence of drug resistant strains. The importance of preventing surgical site infections is well recognized since they lead to increased morbidity, prolonged hospital stays, need for readmission, high end antibiotic treatment and re-surgery. The study was done to see if incidence of SSI is decreased with decreased pre-operative admission time. Others factors associated with SSI were analysed including the microbiological spectrum.Methods: The study was an analytical, observational, case control study. Sixty (60) cases each of gynaecology and obstetrical post-operative patients who developed SSI within 30 days were taken as cases and who did not develop SSI were taken as controls and preoperative admission time was analysed in both cases and controls to observe if risk of surgical site infections decreases due to decreased exposure to nosocomial pathogens when the pre-operative admission time was less than 48 hours.Results: Author found that there was statistically significant difference in the time between surgery and admission in the gynaecological surgeries with p value 0.023, as compared to the obstetrics surgeries where there was no statistically significant difference. Common organism isolated was E. coli sensitive to gentamicin.Conclusions: From this study, it seems to be a good policy to evaluate the patient on OPD basis and admit them about 24 to 48 hours prior to the surgery rather them keeping them admitted for prolonged duration in wards for diagnostic evaluation. This prevents nosocomial contamination in the patient’s skin flora thereby preventing SSI. This practice not only conserves the hospital resources but also makes the patient turn over faster. Further this might in the long run reduce the antibiotic resistant hospital flora.
Feto maternal outcome in obstructed labor: a tertiary centre study
Authors: Bansal Anshul , Kalra Ruchi 
Published: May 2019

Background: The number of maternal deaths as a result of obstructed labor is 8% globally but this number varies in developing country, it ranges 4-70% of all maternal deaths and it is also associated to high perinatal mortality rate. Objective of the study was to find out the proportion of obstructed labour cases and their feto-maternal outcome during last 3 years at tertiary level institute.Methods: A cross sectional observation study was done at Department of Obstetrics and Gynecology, People’s College of Medical Sciences and Research Centre Bhopal. All pregnant women presenting with obstructed labor who delivered at our hospital during last 3 years duration (January 2015 to December 2017) were studied for their feto -maternal outcome.Results: 53% cases had duration of trail more than 16 hours. 84% were referred from primary health centers of nearby rural areas. All cases of obstructed labor delivered by cesarean section (100%). 44% were primigravida. 72% of cases had Cephalopelvic disproportion as the cause. 28% of cases had longer stay more than 7 days at hospital. 32% had fever during post operative period 12.5% cases had wound sepsis and 6% of cases required re-suturing of wound during post operative period. 72% baby's birth weight was between 3 to 3.4 kg. 94% of the babies survived where as 6% of babies were still birth. 16% of babies born to obstructed labor mother had APGAR less than 7 at 5 minutes of birth. 6% fetus were IUFD.Conclusions: Cephalopelvic disproportion was the most common cause for obstructed labor. Timely identification of prolonged labor and timely referral and management at place where operation theatre, NICU and blood bank facilities are available can save the life of both baby and mother.
Maternal and perinatal outcome of Evan’s syndrome: a 5 years study in a tertiary care centre
Authors: K. Manjula S. , T. Jasmine Deva Arul Selvi , N. Vishnu Priya K. M. 
Published: May 2019

Background: Evans syndrome is a rare autoimmune disorder characterized by simultaneous or sequential presence of a positive antiglobulin test, autoimmune haemolytic anemia (AIHA), and immune thrombocytopenia (ITP). It is characterised by frequent exacerbations and remissions within a chronic course. It was first described by Robert Evans in 1951. Incidence of AIHA is 1 per 75 - 80,000 and ITP is 5.5 /100000 per general adult population. Incidence of Evans syndrome is 1.8% to 10% of patients with ITP. Objective was to study the maternal and perinatal outcome of women with Evans syndrome (E).Methods: About 4 antenatal mothers were identified with Evans syndrome at St. Johns medical college and hospital, Bengaluru during the study period of 5 years from July 2013-July 2017. They were followed up during their antenatal, intra natal and postnatal period and outcomes were studied. All patients included in the study fulfilled the criteria for Evans syndrome.Results: There were 4 cases of Evans syndrome, with a total number of deliveries of 11859, during this 5 year study. Incidence was 0.09 per 1000 births. All patients presented with bleeding manifestations ranging from mucosal haemorrhage to subarachnoid haemorrhage (SAH) at the time of diagnosis. All patients were on treatment with either 1st or 2nd line of management with corticosteroids/ azathioprine. None had bleeding during pregnancy after the initiation of treatment. Patients had antenatal complications like preeclampsia 25%, IUGR 25%, oligohydraminos 50%, IUD 25%. 2 patients received platelet transfusions intrapartum. None had intrapartum or postpartum haemorrhage. There were no maternal and neonatal mortality.Conclusions: Evans syndrome in pregnancy is a rare condition and requires multi disciplinary approach involving specialists from obstetrics, neonatology, and hematology. Close maternal and fetal surveillance and management during pregnancy is essential to increase the possibility of a favourable pregnancy outcome in these women.
Malrotation of gut presenting in adolescents and adults at a tertiary care hospital: a prospective study
Authors: Mir Shabir Ahmad , Lattoo Mohd Riyaz , Dar Waseem Ahmad , Wani Mumtazdin 
Published: May 2019

Background: Although malrotation of gut presenting in adolescents and adults is rare, but exists. Also its presentation is nonspecific. Hence its diagnosis needs high index of suspicion.Methods: This prospective study was done in the department of surgery at SMHS hospital (GMC Srinagar) over a period of 5.5 years from July 2012 to December 2017. The patients included all the adolescent and adult patients who proved to be the cases of malrotation of gut on intraoperative visualisation.Results: During the study period, 14 patients with malrotation of gut (belonging to adolescent and adult age group) were recorded. Age of the patients ranged from 16 to 54 years with an average of 26.21±11.15years. Majority of the patients belonged to adolescent age group. Preoperatively CT (computed tomography) scan was done only in 4 patients, thereby making the diagnosis of malrotation preoperatively in these 4 patients. In all other patients, the diagnosis was made only after laparotomy (for acute abdomen) and intraoperative visualisation. Ladd´s procedure was done successfully in majority of patients with two patients requiring resection of gangrenous small bowl and stoma formation.Conclusions: Malrotation of gut presenting in adolescents and adults is a rare phenomenon and also the symptoms are similar to several other abdominal pathologies, hence it represents a diagnostic challenge. Hence a high index of suspicion is needed to diagnose this rare entity early without undue delay. Threshold for CT scan should be kept a little low in suspicious cases so as to diagnose and intervene in time.
A comparison of Tzanakis and Alvarado scoring system in the diagnosis of acute appendicitis
Authors: Anupriya R. , Babu C. P. Ganesh , Rajan K. V. 
Published: May 2019

Background: Appendicitis is the most common abdominal emergency worldwide. Lifetime risk of acute appendicitis is 8.6% and 6.7% for man and women respectively. Clinical examination is helpful in diagnosis of acute appendicitis in only 70-87% of the cases. To compare Tzanaki and Alvarado scoring system in diagnosing acute appendicitis.Methods: This was a prospective, comparative, cross-sectional study, which was conducted at the Mahatma Gandhi Medical College and Research Institute Hospital. Patients with acute appendicitis were included in the study. Relevant history, examination and laboratory investigations done. Patients were scored according to both Alvarado scoring system and Tzanakis scoring, and both were documented in the proforma. Sensitivity, specificity, positive predictive value, negative predictive value were assessed and compared for both scoring systems.Results: 70 patients were included in this study. 54.3% of patients have Tzanakis score more than 8. 35.7% of patients have Alvarado score more than 7. 82.9% of patients had evidence of appendicitis in histopathological examination. Tzanakis score: sensitivity– 65.52%, specificity- 100%, PPV– 100%, NPV– 37.50%, accuracy– 71.43%. Alvarado score: sensitivity– 36.21%, specificity– 66.67%, PPV- 84%, NPV– 17.78%, accuracy– 41.43%.Conclusions: Tzanakis scoring system is an effective scoring system in diagnosing acute appendicitis.
Physical Activity in the Elderly with Fall Experience Over the Past Year: Results from Amirkola Health and Ageing Project
Authors: Safarpour Mehdi , Hosseini Seyed Reza , Fotouhi Akbar , Zeraati Hojjat , Mohamadzade Masume , Bijani Ali 
Published: May 2019

Background and purpose: Nowadays, immobility is known to be the fourth risk factor for mortality. The aim of the present study was to investigate the relationship between fall experience over the previous year and levels of physical activity in the elderly.Materials and Methods: The study was performed with 1616 participants of 60≤ years. The relationship between physical activities in the elderly with age, sex, educational level, body mass index, comorbidities, and fall experience over the previous year was evaluated. Physical activity in the elderly was evaluated using the physical activity scale for the elderly.Results: In the multiple regression model, the age (β: -1.6, 95% CI: -2.0- -1.1), sex, female (β: 11.0, 95% CI: 4.3-17.6), and comorbidities (β: -6.8, 95% CI: -13.5 - -0.1) had a significant relationship with the physical activity score. On the contrary, there was no significant difference between the score of physical activity and both groups with and without the experience of fall over the previous year (β: 0.09, 95% CI: -8.0 - 8.2).Conclusion: Increasing age with comorbidity resulted in a decrease in the average physical activity score in the studied elderly population. However, the experience of fall had no relationship with it. Providing the conditions alongside the training required to carry out physical activities, especially in the elderly people with the disease, was suggested.
Reference Values for Serum Total Cholesterol Concentrations Using Percentile Regression Model: A Population Study in Mashhad
Authors: Esmaeily Habibollah , Dolat Elham , Heidarian Miri Hamid , Taji-Herav Ala , Kiani Omid 
Published: May 2019

Background and Purpose: Serum total cholesterol (TC) concentrations are affected by several factors including ethnicity, diet, geographic, and environmental determinants, and are related to another disease, including hypothyroidism, and renal and liver disease. It is associated with an increased risk of cardiovascular disease, particularly if associated with high levels of serum low-density lipoprotein (LDL). The distribution of TC levels within populations may be useful, and the current study aimed to determine the reference values and specific cut points in a population sample from Mashhad, Iran.Methods: A cross-sectional study was conducted, and data was collected from 6518 individuals (2483 men and 4035 women) aged 25–64 year-old living in Mashhad city using a stratified cluster random sampling design.Reference values for borderline and high TC levels in three age groups were obtained using a percentile regression model. Data were analyzed using Quantreg Software Package and R Ver. 3.1.2 Software.Results: Within the population sample, 38% of the subjects were male and 62% of them were female. The mean and standard deviation for age were found to be 47.07±9 years and 45.28±9 years for men and women, respectively. Percentile regression showed that borderline TC levels for men and women aged 25-64 years were 198-216 mg/dl and 176-243mg/dl, respectively. The values for defining high TC levels were also 226-239 mg/dl in men and 202 - 271 mg/dl in women.Conclusion: Our study estimated reference values and cut points for borderline and high TC separately in both men and women, and age-related sub-groups for a population derived from Mashhad. These findings could be used in local policy plans to allocate health resources.
A ATRATIVIDADE DA DOCÊNCIA NA EDUCAÇÃO INFANTIL EM INGRESSANTES DO CURSO DE PEDAGOGIA
Authors: Corrêa Carla Patrícia Quintanilha , Vital Mabta Almeida Galdino , Lima Patrícia de Souza Gomes , Guimarães Sabrina Almeida de Azevedo Miranda , Moreira Thayná Barros 
Published: May 2019

Esta pesquisa objetiva investigar a atratividade para a docência na educação infantil entre ingressantes de um Curso de Licenciatura em Pedagogia, buscando conhecer suas impressões iniciais acerca do trabalho do professor com crianças dessa etapa da educação básica. Para isso, utilizamos como instrumento de pesquisa um questionário preenchido por 63 licenciandos que aceitaram colaborar com o estudo. Tendo como fundamentação teórica os trabalhos de Gatti (2014), Tartuce et al. (2010), Kramer (2014), Brandão e Leal (2011), dentre outros, obtivemos como resultado que a docência na educação infantil é a primeira intenção de atuação entre a maioria dos ingressantes, que demonstraram estar cientes da complexidade do trabalho com crianças dessa faixa etária, indicando a necessidade de um trabalho pedagógico voltado aos interesses próprios do público infantil. Esses resultados nos fazem refletir que mesmo em meio a um cenário de baixa atratividade docente, os ingressantes do curso pesquisado parecem valorizar a docência na educação infantil. Esperamos, com este trabalho, enriquecer o debate sobre a temática proposta, reunindo mais dados de pesquisa que auxiliem na discussão sobre a docência na contemporaneidade.
Palavras-chave: Atratividade docente. Educação Infantil. Valorização da docência.
A randomized, double-blind study of the ultrasound assessment of the effect of pharyngeal packing on perioperative gastric volume in nasal surgery
Authors: Temel Mehmet Emrah , TOTOZ Tolga , ERKALP KEREM , TEMEL Gulen Safiye , SELCAN Aysin 
Published: May 2019

Abstract
Background: Pharyngeal packing (PP) is commonly performed to reduce the incidence of perioperative blood ingestion (PBI) in nasal surgery (NS), and thus the incidence and severity of postoperative nausea and vomiting (PONV). This study examined the effects of PP on the perioperative gastric volume (GV) and PONV in patients undergoing NS, by ultrasound assessment.
Methods: Patients undergoing elective NS [septoplasty, septo-rhinoplasty (SRP) and functional endoscopic sinus surgery (FESS)] were randomised to receive or not receive PP. In the PP group, pharyngeal packs were placed after the orotracheal intubation. Ultrasound assessments were performed for all patients preoperatively (before the anaesthesia induction) and postoperatively (before the extubation). The antero-posterior (AP) and cranio-caudal (CC) antral diameters, antral cross-sectional area (ACSA), and total GV were calculated. PONV incidence and severity were rated. These variables were compared between timepoints and groups, and in the subgroup analyses according to the surgery type. Pearson correlation analysis was performed to assess correlations between the variables.
Results: AP and CC diameters and ACSAs were greater postoperatively than preoperatively in the PP and non-PP groups (n = 44 each; all p < 0.05). Postoperative AP and CC diameters and the ACSA were greater in the non-PP than in the PP group (all p < 0.05). Postoperative AP diameters were greater than preoperatively in patients undergoing SRP and FESS, and the postoperative CC diameter and ACSA were greater than preoperatively in patients undergoing SRP (all p < 0.05). Surgery duration was correlated positively with postoperative AP diameter (r = 0.380, p < 0.05), CC diameter (r = 0.291, p < 0.05), and ACSA (r = 0.369, p < 0.05). Patients who underwent septoplasty surgery, PP was decreased PONV incidence and severity at the first four hours, postoperatively (p < 0.05).
Conclusions: The study findings indicate that PP reduces the increase in the perioperative GV due to PBI in an elective NS. It is therefore a useful and safe means of reducing the risk of perioperative pulmonary aspiration in such surgeries.