bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution and Variation of the Surface Sensible Heat Flux Over the Central and Eastern Tibetan Plateau: Comparison of Station Observations and Multireanalysis Products
Authors: Chen Lian , Pryor Sara C. , Wang Hui , Zhang Renhe 
Published: May 2019

AbstractSurface sensible heat fluxes (SH) over Tibetan Plateau (TP) dictate the seasonal conversion, onset and maintenance of the Asian monsoon. Spatiotemproal variability in SH over central and eastern TP (CETP) from reanalysis products (i.e., JRA55, ERA‐Interim, NCEP1, and NCEP2) and derived using bulk transfer approximations applied to observations is characterized for all seasons during 1980–2015 and is diagnosed in the context of two important drivers of variability: wind speed and land‐air temperature difference (Tg‐Ta). In the climatological mean, SH from observations increases from east to west and exhibits obvious seasonality with highest value in spring and lowest in winter. Declines in SH prior to 2000 as manifest in the observations appears to have resulted from changes in wind speeds, and the subsequent recovery is attributable to increases in both wind speeds and air‐surface temperature gradients. The intercomparison shows that ERA‐Interim exhibits greatest accord with observations in terms of the climatological distribution and seasonality, and all reanalyses exhibit some aspects of the temporal variability and long‐term trends as manifest in the observations. However, the root causes of the long‐term variability in SH as manifest in the reanalysis products are not consistent with inferences derived from the observations.
Subseasonal‐to‐Seasonal Predictability of the Southern Hemisphere Eddy‐Driven Jet During Austral Spring and Early Summer
Authors: Byrne Nicholas J. , Shepherd Theodore G. , Polichtchouk Inna 
Published: May 2019

AbstractSeveral recent studies have suggested that the stratosphere can be a source of subseasonal‐to‐seasonal predictability of Southern Hemisphere circulation during the austral spring and early summer seasons, through its influence on the zonal‐mean eddy‐driven jet. We exploit the large sample size afforded by the hindcasts from the European Centre for Medium‐Range Weather Forecasts Integrated Forecast System to address a number of unanswered questions. It is shown that the picture of coherent seasonal variability of the coupled stratosphere‐troposphere system apparent from the reanalysis record during the spring/early summer period is robust to sampling uncertainty and that there is evidence of nonlinearity in the case of the most extreme variations. The effect of El Niño–Southern Oscillation on the eddy‐driven jet during this time of year is found to occur via the stratosphere, with no evidence of a direct tropospheric pathway. A simple two‐state statistical model of the stratospheric vortex is introduced to estimate the subseasonal‐to‐seasonal predictability associated with shifts of the seasonal cycle in the Southern Hemisphere extratropical atmosphere. This simple model, along with a more general model, is subsequently used to interpret skill scores associated with hindcasts made using the full seasonal forecast system. Together, the results provide evidence of tropospheric predictability on subseasonal‐to‐seasonal timescales during this time of year from at least as early as 1 August and show no evidence of a “signal‐to‐noise paradox” between the hindcasts and the reanalysis.
The Role of GeoHealth in Science During Crisis
Authors: Colwell Rita R. , Machlis Gary E. 
Published: May 2019

AbstractThe likelihood that crisis events will increase in number and severity is significant. Science has served, and will continue to serve, to address crisis events, whether natural or human attributed. Science during crisis has distinctive requirements. A call to action for science during crisis has been made, and described here are recommendations for response by scientists, including those in disciplines associated with GeoHealth.
Electron Sublayers and the Associated Magnetic Topologies in the Inner Low‐Latitude Boundary Layer
Authors: Dong X.‐C. , Dunlop M. W. , Trattner K. J. , Wang T.‐Y. , Pu Z. Y. , Zhao J.‐S. , Cao J.‐B. , Giles Barbara , Russell C. T. 
Published: May 2019

AbstractThe low‐latitude boundary layer (LLBL) plays an important role as a transition layer in coupling the magnetosheath and magnetosphere. Using high‐resolution Magnetospheric Multiscale data, we analyze the electron distributions in the inner region of the LLBL, during an active period of magnetic reconnection under southward interplanetary magnetic field. According to the measured electron energy anisotropy, we suggest that this inner LLBL can be divided into six sublayers corresponding to three types of magnetic field‐line topologies: (1) open magnetic field line topology from magnetosheath to southern magnetosphere, (2) open magnetic field line topology from magnetosheath to northern magnetosphere, and (3) reclosed magnetic field line topology. These different scenarios indicate that magnetic reconnection occurs at both northern and southern locations of the spacecraft and thus suggest that magnetic reconnection was active simultaneously at high and low latitude on the magnetopause, equatorward of the cusps. These results provide evidence within the LLBL for such multiple X‐line formation.
How Do Ultra‐Low Frequency Waves Access the Inner Magnetosphere During Geomagnetic Storms?
Authors: Rae I. Jonathan , Murphy Kyle R. , Watt Clare E.J. , Sandhu Jasmine K. , Georgiou Marina , Degeling Alex W. , Forsyth Colin , Bentley Sarah N. , Staples Frances A. , Shi Quanqi 
Published: May 2019

AbstractWave‐particle interactions play a key role in radiation belt dynamics. Traditionally, ultra‐low frequency (ULF) wave‐particle interaction is parameterized statistically by a small number of controlling factors for given solar wind driving conditions or geomagnetic activity levels. Here we investigate solar wind driving of ULF wave power and the role of the magnetosphere in screening that power from penetrating deep into the inner magnetosphere. We demonstrate that during enhanced ring current intensity, the Alfvén continuum plummets, allowing lower frequency waves to penetrate deeper into the magnetosphere than during quiet periods. With this penetration, ULF wave power is able to accumulate closer to the Earth than characterized by statistical models. During periods of enhanced solar wind driving such as coronal mass ejection driven storms, where ring current intensities maximize, the observed penetration provides a simple physics‐based reason for why storm time ULF wave power is different compared to nonstorm time waves.
Maximum Solid Phase Concentration in Geophysical Turbulent Gas‐Particle Flows: Insights From Laboratory Experiments
Authors: Weit A. , Roche O. , Dubois T. , Manga M. 
Published: May 2019

AbstractThe maximum solid phase concentration in geophysical turbulent gas‐particle mixtures is essential for understanding the flow dynamics but is poorly known. We present laboratory experiments on turbulent mixtures of air and ceramic particles generated in a vertical pipe. The mixtures had maximum bulk concentrations Cmax = 0.7–2.4 vol. % set by the onset of clustering and that increased with the degree of turbulence. Comparison with results of similar experiments with less dense (glass) particles reveals that Cmax increases with the particle Reynolds number according to Cmax = 0.78 × Rep0.17. Published results of experiments at specific Rep in different configurations are consistent with our data, suggesting that the model for Cmax may be generally applicable to turbulent mixtures. From our empirical laws we infer that natural turbulent gas‐particle flows with Rep ~ 102–105 have maximum solid concentrations of ~2–5 vol. %.
Adipose HuR protects against diet-induced obesity and insulin resistance
Authors: Li Jingyuan , Gong Li , Liu Shaozhuang , Zhang Yujie , Zhang Chunmei , Tian Mi , Lu Huixia , Bu Peili , Yang Jianmin , Ouyang Changhan , Jiang Xiuxin , Wu Jiliang , Zhang Yun , Min Qing , Zhang Cheng , Zhang Wencheng 
Published: May 2019

AbstractHuman antigen R (HuR) is a member of the Hu family of RNA-binding proteins and is involved in many physiological processes. Obesity, as a worldwide healthcare problem, has attracted more and more attention. To investigate the role of adipose HuR, we generate adipose-specific HuR knockout (HuRAKO) mice. As compared with control mice, HuRAKO mice show obesity when induced with a high-fat diet, along with insulin resistance, glucose intolerance, hypercholesterolemia and increased inflammation in adipose tissue. The obesity of HuRAKO mice is attributed to adipocyte hypertrophy in white adipose tissue due to decreased expression of adipose triglyceride lipase (ATGL). HuR positively regulates ATGL expression by promoting the mRNA stability and translation of ATGL. Consistently, the expression of HuR in adipose tissue is reduced in obese humans. This study suggests that adipose HuR may be a critical regulator of ATGL expression and lipolysis and thereby controls obesity and metabolic syndrome.
Dose-response association of serum alanine aminotransferase levels with multimorbidity
Authors: Zhang Yuxia , Yu Lugang , Wang Xiaoying , Qin Liqiang , Shen Yueping , Ke Chaofu 
Published: May 2019

AbstractMultimorbidity has posed a major challenge to health care systems worldwide, but little is known about its association with biological factors. This study represents the first one to examine the association of serum levels of alanine aminotransferase (ALT) with multimorbidity. The baseline category logistic regression model was used to estimate the odds ratio (OR) between ALT and multimorbidity, and the area under the receiver operating characteristic curve (AUC) was used to evaluate the classification utility of ALT. Serum ALT levels were associated, in a dose-response manner, with multimorbidity. Compared with the first quartile, the adjusted OR (95% confidence interval) of the fourth quartile for multimorbidity was 4.71 (3.56–6.23). In addition, the AUC value for distinguishing the multimorbidity group from the control group reached 0.7185. In conclusion, high levels of ALT were significantly correlated with multimorbidity and this association was independent of other potential risk factors. Serum ALT might be a useful marker for identifying individuals with multimorbidity.
ZIKV Strains Differentially Affect Survival of Human Fetal Astrocytes versus Neurons and Traffic of ZIKV-Laden Endocytotic Compartments
Authors: Jorgačevski Jernej , Korva Miša , Potokar Maja , Lisjak Marjeta , Avšič-Županc Tatjana , Zorec Robert 
Published: May 2019

AbstractMalformations of the fetal CNS, known as microcephaly, have been linked to Zika virus (ZIKV) infection. Here, the responses of mammalian and mosquito cell lines, in addition to primary human fetal astrocytes and neurons were studied following infection by ZIKV strains Brazil 2016 (ZIKV-BR), French Polynesia 2013 (ZIKV-FP), and Uganda #976 1947 (ZIKV-UG). Viral production, cell viability, infectivity rate, and mobility of endocytotic ZIKV-laden vesicles were compared. All cell types (SK-N-SH, Vero E6, C6/36, human fetal astrocytes and human fetal neurons) released productive virus. Among primary cells, astrocytes were more susceptible to ZIKV infection than neurons, released more progeny virus and tolerated higher virus loads than neurons. In general, the infection rate of ZIKV-UG strain was the highest. All ZIKV strains elicited differences in trafficking of ZIKV-laden endocytotic vesicles in the majority of cell types, including astrocytes and neurons, except in mosquito cells, where ZIKV infection failed to induce cell death. These results represent a thorough screening of cell viability, infection and production of three ZIKV strains in five different cell types and demonstrate that ZIKV affects vesicle mobility in all but mosquito cells.
Effects of açai on oxidative stress, ER stress, and inflammation-related parameters in mice with high fat diet-fed induced NAFLD
Authors: de Freitas Carvalho Mayara Medeiros , Lage Nara Nunes , de Souza Paulino Alice Helena , Pereira Renata Rebeca , de Almeida Letícia Trindade , da Silva Tales Fernando , de Brito Magalhães Cíntia Lopes , de Lima Wanderson Geraldo , Silva Marcelo Eustáquio , Pedrosa Maria Lucia , da Costa Guerra Joyce Ferreira 
Published: May 2019

AbstractNon-alcoholic fatty liver disease (NAFLD), the most predominant liver disease worldwide, is a progressive condition that encompasses a spectrum of disorders ranging from steatosis to steatohepatitis, and, ultimately, cirrhosis and hepatocellular carcinoma. Although the underlying mechanism is complex and multifactorial, several intracellular events leading to its progression have been identified, including oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and altered endoplasmic reticulum (ER) homeostasis. Phenolic compounds, such as those present in açai (Euterpe oleracea Mart.), are considered promising therapeutic agents due to their possible beneficial effects on the prevention and treatment of NAFLD. We tested in vitro effects of aqueous açai extract (AAE) in HepG2 cells and its influence on oxidative stress, endoplasmic reticulum stress, and inflammation in a murine model of high fat diet-induced NAFLD. In vitro AAE exhibited high antioxidant capacity, high potential to inhibit reactive oxygen species production, and no cytotoxicity. In vivo, AAE administration (3 g/kg) for six weeks attenuated liver damage (alanine aminotransferase levels), inflammatory process (number of inflammatory cells and serum TNFα), and oxidative stress, through the reduction of lipid peroxidation and carbonylation of proteins determined by OxyBlot and modulation of the antioxidant enzymes: glutathione reductase, SOD and catalase. No change was observed in collagen content indicating an absence of fibrosis, stress-related genes in RE, and protein expression of caspase-3, a marker of apoptosis. With these results, we provide evidence that açai exhibits hepatoprotective effects and may prevent the progression of liver damage related to NAFLD by targeting pathways involved in its progression.
Modelling soil detachment by overland flow for the soil in the Tibet Plateau of China
Authors: Li Mingyi , Hai Xiao , Hong Huan , Shao Yanyan , Peng Doudou , Xu Wennian , Yang Yueshu , Zheng Yan , Xia Zhenyao 
Published: May 2019

AbstractThe overland flow erosion is common and became more serious because of the climate warming inducing more runoff in the Tibet Plateau. The purposes of this study were to evaluate the effects of flow rate, slope gradient, shear stress, stream power, unit stream power and unit energy of water-carrying section on the soil detachment capacity for the soil in the Tibet Plateau of China due to the information is limited. To achieve this aim, laboratory experiments were performed under six flow rates (5, 10, 15, 20, 25 and 30 L min−1) and six slope gradients (8.74%, 17.63%, 26.79%, 36.40%, 46.63 and 57.73%) by using a slope-adjustable steel hydraulic flume (4 m length, 0.4 m width, 0.2 m depth). The results indicated that soil detachment capacity ranged from 0.173 to 6.325 kg m−2 s−1 with 1.972 kg m−2 s−1 on average. The soil detachment capacity increased with power function as the flow rate and the slope gradient augmented (R2 = 0.965, NRMSE = 0.177 and NSE = 0.954). The soil detachment capacity was more influenced by flow rate than by slope gradient in this study. The relation between soil detachment capacity and shear stress, stream power, unit stream power and unit energy of water-carrying section can be described by using the linear function and power function, the power function relationship performed better than the linear function in generally. The stream power exhibits the best performance in describing the soil detachment capacity among shear stress, stream power, unit stream power and unit energy of water-carrying section in this study. The erodibility value in this study was larger than and the critical shear stress was less than those for soil in the eastern China. There has a huge potential for the soil in the Tibet Plateau eroded by the water erosion when enough runoff exiting. More attention should be payed to the water erosion process and mechanism in the Tibet Plateau area in the future.
Association between TGF-β1 -913G/C polymorphism and myocardial infarction risk in a Chinese Han population: a case–control study
Authors: Wu Lili , Chen Guofan , Song Jia 
Published: May 2019

Abstract
Transforming growth factor (TGF)-β1 contributed to angiotensin II (Ang II)-mediated collagen accumulation after myocardial infarction (MI). The present study aimed to investigate the association of genetic variant of TGF-β1 gene with the risk of MI. The present study recruited a total of 530 MI patients and 651 healthy controls. The genomic DNA was extracted and subjected into polymerase chain reaction (PCR) and Sanger sequencing. The present study indicated that TGF-β1 -913G/C polymorphism was associated with increased risk for MI under the co-dominant, dominant and allelic models. The increased risk effect was also evident among the females, younger subjects (age &lt; 60 years), smokers, non-drinkers and individuals with hypertension. Additionally, the present study observed significant differences among cases and controls in terms of total cholesterol (TC). In conclusion, TGF-β1 -913G/C polymorphism is associated with increased risk for MI. TGF-β1 -913G/C polymorphism may be a potential prognostic biomarker for MI.
Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling
Authors: Wang Da-hua , He Xi , He Qing 
Published: May 2019

Abstract
Phillyrin (PHN), one of the major active constituents of Forsythia suspensa and F. koreana, has been reported to produce antioxidant, antibacterial, anti-obesity and anti-inflammatory effects. However, no study has demonstrated the role of PHN in laryngeal squamous cell carcinoma (LSCC). We aimed to investigate the effects of PHN on the proliferation and apoptosis of HEp-2 cells. In the present study, PHN alone showed little effect on HEp-2 cell proliferation and apoptosis. Subsequent tests showed that PHN could largely enhance the level of autophagy on HEp-2 cells. Combining use of PHN and autophagy blockers including 3-methyladenine (3-MA) and chloroquine (CQ) significantly inhibited HEp-2 cell proliferation in a dose- and time-dependent manner and induced apoptosis after 24 h in a dose-dependent manner. Additionally, we found that the possible underlying molecular mechanism of PHN-induced autophagy might be through the AMPK/mTOR/p70S6K signaling pathway. Taken together, our study indicates that combining use of PHN and autophagy blockers may serve as a novel strategy in LSCC treatment.
A Single-Center Experience with a Pregnant Immigrant Population and Zika Virus Serologic Screening in New York City
Authors: Merriam Audrey A. , Nhan-Chang Chia-Ling , Huerta-Bogdan B. Isabel , Wapner Ronald , Gyamfi-Bannerman Cynthia 
Published: May 2019

Objective Our institution is in an area of New York City with a large population of immigrants from Zika virus endemic areas. With the recent Zika virus outbreak, we sought to examine our center's experience with screening for Zika virus and outcomes among patients who tested positive for the disease during pregnancy.
Study Design We performed a chart review of all pregnant patients who tested positive (positive serum or urine polymerase chain reaction [PCR]) or presumed positive (immunoglobulin M [IgM] enzyme-linked immunosorbent assay [ELISA] positive or IgM ELISA equivocal with positive plaque reduction neutralization test) for Zika virus. All tests were performed by the Department of Health (DOH) and followed Centers for Disease Control and Prevention guidelines in effect at the time of specimen collection. Testing of cord blood, placenta, and/or neonatal blood were/was performed by the DOH for New York County. Prenatal ultrasounds for fetal head size and surveillance for calcifications were performed by maternal–fetal medicine specialists. Infant head ultrasound results were included when available.
Results Between March 2016 and April 2017, 70 pregnant patients were positive or presumed positive for Zika infection during pregnancy. Of those, 16 women had positive urine or serum PCR and the remaining 54 were presumed positive. Among positive cases, five women tested positive via urine PCR only, nine women tested positive via serum PCR only, and two women had both positive urine and serum PCR. Fifteen of 67 infants (22%) born during the study period were born to mothers with positive urine or serum PCR testing. Sixty-five newborns were clinically normal with normal head measurements. Of the intracranial ultrasound performed, one infant had a grade 1 intraventricular hemorrhage, four had incidental choroid plexus cysts, and one had severe ventriculomegaly that was also noted antenatally. There were 2 positive and 15 equivocal infant serum IgM samples and 1 positive placental PCR from these pregnancies. There were four pregnancy terminations and two cases with fetal anomalies in this population that were split evenly between patients who tested positive and those who tested presumed positive for Zika virus during pregnancy.
Conclusion We found no differences in pregnancy or neonatal outcomes between women who tested positive and presumed positive for Zika virus during pregnancy. Testing of infants and placenta tissue after delivery was largely inconclusive. Improvement in testing for Zika virus infection is needed to determine which pregnancies are at risk for congenital anomalies. Further research is still needed to determine which children are at risk for poor neurodevelopmental outcomes related to Zika virus and how to best coordinate care among the immigrant population during a new disease epidemic.
Is Delaying Cord Clamping until Placenta Delivery Beneficial? Oxygen Saturation and Heart Rate Transition during the Initial 5 Minutes after Delivery in Indian Healthy Newborns
Authors: Mukherjee Suchandra , Bulsara Jignesh S. , Das Manoja Kumar , Waratakar Yogendra , Saha Anindya Kumar , Dubey Sunil , Mehta Pratima , Gupta Bini , Singh Arun K. ,   for Indian Delayed Cord Clamp Study Group
Published: May 2019

Objective This study aimed to compare the preductal oxygen saturation (SpO2) and heart rate (HR) in newborns during the initial 5 minutes after birth with delayed cord clamping (DCC) and early cord clamping (ECC) practices at sea level.
Study Design This prospective observational study included newborns born at >34 weeks vaginally (Dharampur, Gujarat) or through caesarean section (CS) (Kolkata, West Bengal). In Dharampur, the newborns received ECC practice (8 weeks) followed by DCC practice (10 weeks). In Kolkata, the newborns received ECC practice only (8 weeks).
Results The newborns with DCC (n = 170) had significantly higher SpO2 (3–8%) throughout than those with ECC born either vaginally (n = 178) or through CS (n = 101). The newborns with DCC had slower rise in HR during the first 2 minutes than those with ECC. The 5th and 10th percentile values of SpO2 for newborns with DCC practice were higher than those with ECC practice.
Conclusion The trends of SpO2 and HR during the first 5 minutes after birth indicate a relatively smoother cardiopulmonary transition by delaying cord clamping till placental delivery compared with early clamping. The reference ranges can be used for Indian newborns born by uncomplicated vaginal delivery with DCC during the first 5 minutes.