bluuebunny/crossref_metadata_2025_split huggingface dataset:
A sense of belonging: A meta‐ethnography of the experience of patients with chronic obstructive pulmonary disease receiving care through telemedicine
Authors: Barken Tina Lien , Söderhamn Ulrika , Thygesen Elin 
Published: June 2019

AbstractAimTo synthesize the qualitative research in the literature addressing how patients with chronic obstructive pulmonary disease experience care received by telemedicine.DesignMeta‐ethnography.Data SourcesTwelve studies, published from 2013 – 2018, were identified by a search of relevant systematic databases in June 2017, including updated searches performed in June 2018.Review MethodsThe studies were reviewed and critically appraised independently by three researchers. The review followed the seven steps of meta‐ethnography developed by Noblit and Hare, including a line‐of‐argument synthesis.ResultsThe synthesis revealed three second‐order constructs: presence, transparency, and ambivalence. Using a line‐of‐argument synthesis, a model was developed that showed patients’ experience of a sense of belonging when receiving care by telemedicine.ConclusionThis meta‐ethnography contributes to the existing and contradictory evidence base of telemedicine to chronic obstructive pulmonary disease patients. It addresses and adds renewed understanding of who would benefit from telemedicine and why, by illustrating the interrelationship between the conditions of telemedicine care, the severity of COPD, and the need for connectedness and emphasizes that the need to belong in telemedicine care increases with the progression of illness burden and severity.ImpactThe present study endorses the view that the patients with a severe illness burden are likely to benefit the most when receiving care by telemedicine. However, the benefits rely on the fact that the telemedicine interventions involve emotional, social, and clinical support, including regular contact with healthcare professionals, to meet the requirements to belong.
Minimally invasive thoracoscopic surgery is an effective approach for treating inappropriate sinus tachycardia
Authors: Aalaei‐Andabili Seyed Hossein , Miles William M. , Burkart Thomas A. , Panna Mark E. , Conti Jamie B. , McKillop Matthew S. , Beaver Thomas M 
Published: June 2019

AbstractIntroductionInappropriate sinus tachycardia (IST) is characterized by increased heart rate out of proportion to normal physiologic demand. IST ablation is challenging for the electrophysiology community due to the epicardial location of the sinus node and the risk of phrenic nerve (PN) injury during catheter ablation. In this study, we investigated the safety and efficacy of a minimally invasive thoracoscopic surgery for elimination of IST.MethodsPatients with IST who failed medical therapy or endocardial ablation underwent minimally invasive thoracoscopic epicardial ablation. Epicardial activation mapping was performed to identify the earliest activation site and any possible migration of earliest activation along the lateral right atrium. The PN in each patient was protected by a pericardial retraction suture.ResultsFrom 1 January 2000 to 15 June 2018, 10 patients (eight females and two males) underwent minimally invasive thoracoscopic IST ablation. Mean age of the patients was 36.7 ± 12.5 years. Mean baseline sinus rate was 113.8 ± 21.8 beats per minute. After surgery, the mean heart rate significantly decreased to 79.8 ± 8.2 at postoperative day 1 and to 75.8 ± 8.1 at day 30 (both P < .001). No in‐hospital death, stroke, or PN injury occurred. One patient required reintubation, one patient developed postoperative pericarditis, and another patient had a pulmonary embolus. Median follow‐up was 6 months (range, 1‐50). Freedom from reintervention was 88% at 6 months.ConclusionMinimally invasive thoracoscopic ablation for IST is a safe and effective approach that preserves the phrenic nerve. Due to the possibility of IST activation site migration, continued follow‐up after surgery is required.
Regional isolation in the right atrium with disruption of intra‐atrial conduction after catheter ablation of atrial tachycardia
Authors: Markowitz Steven M. , Choi Daniel Y. , Daian Foysal , Liu Christopher F. , Cheung Jim W. , Thomas George , Ip James E. , Lerman Bruce B. 
Published: June 2019

AbstractBackgroundAblation of atrial tachycardia (AT) that occurs after cardiac surgery or prior ablation often requires complex lesion sets. In combination with the pre‐existing atrial scar, these lesion sets may result in inadvertent intra‐atrial conduction block. This study reports the phenomenon of incidental isolation of right atrial (RA) regions that occurs secondary to AT ablation, which in some cases results in profound bradycardia due to sinus exit block.Methods and ResultsIntracardiac electrograms were examined in consecutive patients who underwent AT ablation in the RA. Cases of localized isolation of the RA were defined as areas that developed electrical dissociation during ablation. Of 132 patients having ablation in both the RA free wall and the cavotricuspid isthmus (CTI), 10 (7.6%) developed unintentional isolation of the lateral RA. Five of these patients had prior mitral valve surgery, comprising 12.2% of all 41 patients with mitral surgery who underwent ablation in the CTI and the RA free wall. All patients with regional isolation had a pre‐existing scar in the lateral wall of the RA. In six patients, isolation of the lateral RA resulted in profound bradycardia due to exit block from the peri‐sinus node myocardium.ConclusionsComplex ablation lesions in patients with prior valve surgery, prior ablation, or atrial myopathy may result in unintended localized conduction block in the RA. In some cases, isolation of the lateral RA can result in complete sinus exit block with profound bradycardia requiring pacemaker implantation.
Pulse wave velocity progression over a medium‐term follow‐up in hypertensives: Focus on uric acid
Authors: Maloberti Alessandro , Rebora Paola , Andreano Anita , Vallerio Paola , De Chiara Benedetta , Signorini Stefano , Casati Marco , Besana Silvia , Bombelli Michele , Grassi Guido , Valsecchi Maria Grazia , Giannattasio Cristina 
Published: June 2019

AbstractThe role of uric acid (UA) on the arterial stiffness progression has been evaluated only in three studies. Our aim was to evaluate its role as a possible determinant of the pulse wave velocity (PWV) progression over a 3.7 ± 0.5 years follow‐up period in hypertensive patients. Specific sex analysis was done due to the well‐known sex interaction with UA levels. We enrolled 422 consecutive hypertensive outpatients. At baseline anamnestic, blood pressure (BP) and laboratory data as well as PWV were assessed. PWV was performed again at follow‐up examination. Hyperuricemia was defined as a UA > 6 mg/dL for women and > 7 mg/dL for men. Baseline age was 53.2 ± 13 years, 58% were males, systolic and diastolic BP (SBP/DBP) 141.7 ± 17.7/86.8 ± 10.8 mm Hg, UA 5.2 ± 1.4 mg/dL, and PWV 8.5 ± 1.9 m/s. At follow‐up, despite better BP values (−8.5 ± 24.6 for SBP and −7.5 ± 15.4 for DBP), PWV increases to 9.1 ± 2.3 m/s (P < 0.001) with mean ΔPWV of+ 0.5 ± 2.2 m/s. A total of 61 patients were hyperuricemic (14.4%), and they present higher PWV baseline (9.0 ± 2.5 vs 8.5 ± 1.8 m/s, P = 0.03) without significant differences in ΔPWV. Hyperuricemic female (6.2%, 11 patients) presents higher baseline PWV without significant differences in ΔPWV. No differences were found in arterial stiffness in hyperuricemic males (20.4%, 50 patients). UA showed association with baseline and ΔPWV in the whole population but it loses statistical significance at the linear regression model. Same figures were also for sex analysis. Our findings provide evidence that baseline UA levels are not determinants of PWV progression over a median follow‐up of 3.8 years’ in hypertensive patients.
Yellow Wine Polyphenolic Compounds prevents Doxorubicin‐induced cardiotoxicity through activation of the Nrf2 signalling pathway
Authors: Lin Hui , Zhang Jie , Ni Tingjuan , Lin Na , Meng Liping , Gao Feidan , Luo Hangqi , Liu Xiatian , Chi Jufang , Guo Hangyuan 
Published: June 2019

AbstractDoxorubicin (DOX) is considered as the major culprit in chemotherapy‐induced cardiotoxicity. Yellow wine polyphenolic compounds (YWPC), which are full of polyphenols, have beneficial effects on cardiovascular disease. However, their role in DOX‐induced cardiotoxicity is poorly understood. Due to their antioxidant property, we have been suggested that YWPC could prevent DOX‐induced cardiotoxicity. In this study, we found that YWPC treatment (30 mg/kg/day) significantly improved DOX‐induced cardiac hypertrophy and cardiac dysfunction. YWPC alleviated DOX‐induced increase in oxidative stress levels, reduction in endogenous antioxidant enzyme activities and inflammatory response. Besides, administration of YWPC could prevent DOX‐induced mitochondria‐mediated cardiac apoptosis. Mechanistically, we found that YWPC attenuated DOX‐induced reactive oxygen species (ROS) and down‐regulation of transforming growth factor beta 1 (TGF‐β1)/smad3 pathway by promoting nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) nucleus translocation in cultured H9C2 cardiomyocytes. Additionally, YWPC against DOX‐induced TGF‐β1 up‐regulation were abolished by Nrf2 knockdown. Further studies revealed that YWPC could inhibit DOX‐induced cardiac fibrosis through inhibiting TGF‐β/smad3‐mediated ECM synthesis. Collectively, our results revealed that YWPC might be effective in mitigating DOX‐induced cardiotoxicity by Nrf2‐dependent down‐regulation of the TGF‐β/smad3 pathway.
Age‐dependent effect between MARCO and TLR4 on PMMA particle phagocytosis by macrophages
Authors: Yamada Chiaki , Beron‐Pelusso Camila , Algazzaz Neira , Heidari Alireza , Luz Diogo , Rawas‐Qalaji Mutasem , Toderas Ion , Mascarenhas Ana Karina , Kawai Toshihisa , Movila Alexandru 
Published: June 2019

AbstractProgressive generation of total joint implant‐derived wear particles is one of the major risk factors in development of peri‐prosthetic osteolysis especially in the aging society. It is commonly accepted that macrophages predominantly drive the inflammatory response to wear debris particles. Among various surface receptors that activate the macrophages to phagocytize particles, it is believed that the Toll‐like receptor 4 (TLR4) and the scavenger macrophage receptor with collagenous structure (MARCO) play key roles in recognition of wear debris particles. However, a strong body of evidence indicates an age‐dependent diminished function of human TLRs. Thus, we hypothesized that the MARCO receptor may be more engaged than TLRs in the phagocytosis of wear debris particles which in turn up‐regulate production of pro‐inflammatory cytokines from aged macrophages. We demonstrated that peritoneal macrophages isolated from aged mice show elevated expression of MARCO receptor compared to that from young mice. In contrast the expression of TLR4 was significantly decreased on the surface of aged macrophages. Furthermore, using anti‐MARCO and anti‐TLR4 neutralizing mAbs, we demonstrated the age‐dependent pathogenic role of MARCO, but not TLR4, receptor in promoting poly‐methyl methacrylate (PMMA) bone cement particles phagocytosis by macrophages leading to the release of pro‐inflammatory cytokines migration inhibitory factor and tumour necrosis factor in vitro. These data also suggest that the approach to neutralize MARCO may lead to the development of therapeutic regimen for the prevention of particle‐induced osteolysis in aged patients.
Optimization of mechanical oil extraction process from Camellia oleifera seeds regarding oil yield and energy consumption
Authors: Huang Shuai , Hu Youmin , Li Fengcheng , Jin Wenwen , Godara Vikas , Wu Bo 
Published: June 2019

AbstractMechanical pressing is widely used for producing high‐quality vegetable oil in industry. However, mechanical pressing process faces a challenge from meeting the industrial demand for high yield with low energy consumption. Hence, the objective of this study was to optimize mechanical oil extraction process from Camellia oleifera seeds by maximizing the yield and minimizing the energy consumption. A Box–Behnken design of response surface methodology is adopted for the experiments of mechanical oil extraction from C. oleifera seeds. The effects of experimental factors namely moisture content (0–9% w.b.), applied pressure (10–45 MPa), pressing temperature (40–100°C) and extraction time (10–40 min) on yield and energy consumption were investigated by modeling the oil extraction process. An analysis of variance (ANOVA) revealed that moisture content, applied pressure and extraction time significantly effect on yield while applied pressure, pressing temperature, and extraction time have an obvious influence on energy consumption. In addition, the oil extracted under the processing conditions investigated was validated to be of acceptable quality. The Pareto fronts based on multiobjective genetic algorithm provides a set of optimal process parameters to obtain sustainable end products.Practical ApplicationMoisture content, applied pressure, pressing time, and pressing temperature are primary processing conditions affecting oil extraction from C. oleifera seeds during the mechanical process. The use of inappropriate processing parameters may lead to low yield and high‐energy consumption. Understanding the mechanisms of oil extraction process thoroughly while taking important parameters into consideration is vital for the process to be efficient. This can be obtained by modeling oil extraction process using both experimental and theoretical methods. In this article, how these factors affect the yield and energy consumption of the system were investigated by modeling the oil extraction process. Processing conditions were optimized by multiobjective optimization technique based on NSGA‐II. The oil extracted under the processing conditions investigated was of acceptable quality. The data collected during this study can be utilized to design the equipment and to obtain sustainable end products.
Randomized parallel control trial checking the efficacy and impact of two concentrations of retinol in the original formula on the aging skin condition: Pilot study
Authors: Zasada Malwina , Budzisz Elżbieta 
Published: June 2019

AbstractBackgroundThe aging process is defined as natural, biological, progressive, and physiologically irreversible phenomena occurring in the body.ObjectiveWe attempted to evaluate the efficacy and tolerability of treating signs of the aging skin using retinol 0.15% and 0.3%. Retinol was added to the original, developed liquid crystal formula.MethodsPatients at two sites (n = 20, n = 20) presenting signs of aging applied a novel formulation of retinol at 0.15% (on the left) and 0.3% (on the right) concentrations daily to their faces for 2 months. An expert blinded evaluation of images was carried out after 8 weeks. Tolerability was assessed throughout the whole study. Positive results of the observational pilot study guaranteed a follow‐up trial with the use of the higher concentration and another parallel study.ResultsIn the observational pilot study, most of the participants showed an improvement in the overall skin condition. These improvements were assessed after 4 and 8 weeks. Those observed after 56 days were more remarkable than those identified 28 days, however, without any statistical significance. Application of retinol formula 0.3% and serum 0.15% gives similar results after 8 weeks of daily care. Both products improve the overall skin condition considerably, even the skin color, hydration, and radiance. In a VAS assessment, the number of wrinkles decreased and skin discoloration was reduced. Side effects such as burning, dryness, pruritus, and erythema during the 8‐week study period were minimal.ConclusionsThe topical formulation of liquid crystal serum with retinol 0.15% and 0.3% improves the overall skin condition after 8 weeks. Burning, pruritus, dryness, and erythema caused by the application of retinol 0.15% and 0.3% concentrations were minimal. Nevertheless, there were no significance changes found between the left and right side of the face. These encouraging results justify a longer‐term study to determine whether topically applied retinol 0.3% can provide more benefits as compared to those observed after topical application of retinol 0.15%.
Classification of hydrocolloids based on small amplitude oscillatory shear, large amplitude oscillatory shear, and textural properties
Authors: Alghooneh Ali , Razavi Seyed M. A. , Kasapis Stefan 
Published: June 2019

AbstractDynamic rheological and mechanical properties of seven commercial (xanthan [XG], guar [GG], high methoxylated pectin [HMP], κ‐carrageenan [κ‐Car], agar [AG], alginate [ALG], and carboxymethylcellulose [CMC]) and four emerging hydrocolloids (basil seed gum [BSG], sage seed gum [SSG], Balangu‐Shirazi seed gum [BSSG], and cress seed gum [CSG]) were investigated and the classification of the hydrocolloids were carried out based on them. AG belonged to the first class with 0.81 membership function (MF), κ‐Car and HMP grouped in the second class with 0.68 and 0.71 MFs, respectively, XG, BSG, and SSG were depended to the third class with 0.61–0.70 MFs, finally, CMC, GG, BSSG, ALG, and CSG related to the fourth class, as the most populated class, with MF > 0.61. The first class contained the highest amount of hardness parameter (43.40 ± 2.76 g), the second class included the highest pseudoplasticity parameter (shear‐thinning ratio = −0.54 ± 0.03) and relaxation time (66.25 ± 2.61 s) and the fourth cluster comprised the highest frequency dependency of viscous modulus (exponent of power‐law model for viscous modulus vs. frequency = 0.30 ± 0.05). In addition, the results of this study showed that there was a distinct relationship between nonlinear harmonics in the stress wave and fundamental characteristics of hydrogel networks. The investigation of the rheo‐mechanical properties of biopolymers in large deformation under shear and normal forces can have an important role in the prediction of the behavior of the material in real processes and application conditions, especially in the food industry. Due to the inconvenience of large deformation mechanical tests, such as Weissenberg effect, the complication of the results analyzing and sampling difficulty of semi‐dilute samples; herein, we determined the correlation between large deformation (LAOS and texture analysis) and small deformation (SAOS) tests properties. The studied rheo‐mechanical parameters showed high correlation with the four mentioned network parameters (more than 65% similarity index). Using these results, other scientists could rationally design the experiments and avoid experiments with similar parameters.
Effects of adenovirus‐induced hepatocyte damage on chronic bile duct inflammation in a sclerosing cholangitis mouse model
Authors: Fuchs Sina , Bayer Monika , Taubert Richard , Manns Michael P. , Pfeilschifter Josef M. , Christen Urs , Hintermann Edith 
Published: June 2019

AbstractBackground & AimsFour major autoimmune diseases target the liver. They develop because of bile duct destruction, leading to chronic cholestasis or result from hepatocyte damage like autoimmune hepatitis (AIH). Interestingly, some patients simultaneously show features of both cholangitis and AIH. Our goal was to mimic such concurrent characteristics in a mouse model that would help deciphering mechanisms possibly involved in an inflammatory crosstalk between cholestatic disease and hepatitis.MethodsMdr2−/− mice, which spontaneously develop sclerosing cholangitis because of accumulation of toxic bile salts, were infected with adenovirus (Ad) encoding human Cytochrome P4502D6 (hCYP2D6), the major target autoantigen in type‐2 AIH, to trigger hepatocyte injury. Wild type FVB mice were controls.ResultsResulting Ad‐Mdr2−/− mice presented with cholangitis, fibrosis and cellular infiltrations that were higher than in Mdr2−/− or Ad‐FVB mice. Increased levels of anti‐neutrophil cytoplasmic antibodies but similar anti‐hCYP2D6 antibody titres were detected in Ad‐Mdr2−/− compared to Mdr2−/− and Ad‐FVB mice respectively. IFNγ‐expressing hCYP2D6‐specific CD4 T cells declined, whereas hCYP2D6‐specific CD8 T cells increased in Ad‐Mdr2−/− compared to Ad‐FVB mice. The overall T cell balance in Ad‐Mdr2−/− mice was a combination of a type 17 T cell response typically found in Mdr2−/− mice with a type 1 dominated T cell response characteristic for Ad‐FVB mice. Simultaneously, the type 2 T cell compartment was markedly reduced.ConclusionsExperimental hepatitis induction in a mouse with sclerosing cholangitis results in a disorder which represents not simply the sum of the individual characteristics but depicts a more complex entity which urges on further analysis.
High proportions of children under 3 years of age consume commercially produced snack foods and sugar‐sweetened beverages in Bandung City, Indonesia
Authors: Green Mackenzie , Hadihardjono Dian N. , Pries Alissa M. , Izwardy Doddy , Zehner Elizabeth , Huffman Sandra L. 
Published: June 2019

AbstractChild undernutrition continues to be a national concern in Indonesia, whereas childhood overweight/obesity rises. Economic development has led to wide availability of highly processed foods and beverages, with growing evidence that children are consuming commercial snack products during the critical complementary feeding period. This study assessed the prevalence and patterns of consumption of commercially produced snack foods and sugar‐sweetened beverages among Indonesian children. A cross‐sectional survey was conducted with 495 mothers of children aged 6–35 months living in Bandung City, Indonesia. Among all children, 81.6% consumed a commercial snack food and 40.0% consumed a sugar‐sweetened beverage in the day preceding the interview. At 6–11 months, 46.5% of children consumed a snack food and 2.0% consumed a sugar‐sweetened beverage. Snack foods were consumed 3 or more times a day by 60.0% of children 24–35 months of age. Sweet biscuits and savory snacks were the most commonly consumed snack foods; sweetened milks and sweetened teas were the most common beverages. Maternal education, child age, and consumption of a commercially produced complementary food were associated with snack food consumption. Factors associated with sugar‐sweetened beverage consumption were child age and consumption of a commercially produced complementary food or breastmilk substitute. These findings reflect a high presence of processed, high‐sugar/salt commercial snack products in the diets of children 6–35 months. National attention should focus on interventions to reduce reliance on processed snack products and increase consumption of nutrient‐rich, locally available foods during the complementary feeding period.