bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of intracranial flow diversion according to the antiplatelet regimen used: a systematic review and meta-analysis
Authors: Podlasek Anna , Al Sultan Abdul Aziz , Assis Zarina , Kashani Nima , Goyal Mayank , Almekhlafi Mohammed A 
Published: July 2019

BackgroundThromboembolic complications are not uncommon in patients undergoing neurointerventional procedures. The use of flow diverting stents is associated with higher risks of these complications despite current dual antiplatelet regimens.ObjectiveTo explore contemporary evidence on the safety of emerging dual antiplatelet regimens in flow diverting stenting procedures.MethodsWe performed a systematic review and meta-analysis to identify relevant articles in electronic databases, and relevant references. Studies reporting the complications and mortality of flow diverting stenting procedures using acetyl salicylic acid (ASA) + ticagrelor or ASA + prasugrel compared with ASA + clopidogrel were included.ResultsOf 452 potentially relevant studies, we identified 49 studies (2526 patients) which reported the safety of ticagrelor or prasugrel for pooled analysis, and five studies (1005 patients) for meta-analysis. The pooled overall mortality in all studies was 2.14%, ischemic complications 6.89%, and hemorrhagic complications 3.68%. The use of ticagrelor or prasugrel was associated with a lower risk of mortality compared with clopidogrel (RR=4.57, 95% CI 1.23 to 16.99; p=0.02). Considering ischemic events, ASA + clopidogrel was as safe as ASA + prasugrel (RR=0.55, 95% CI 0.11 to 2.74; p=0.47) and ASA + ticagrelor (RR=0.74, 95% CI 0.32 to 1.74; p=0.49). ASA +ticagrelor was not associated with a higher risk of hemorrhagic complications (RR=0.92, 95% CI 0.27 to 3.16; p=0.89).ConclusionsEvidence suggests that dual antiplatelet regimens including ticagrelor or prasugrel are safe for patients undergoing flow diversion procedures. Regimens using ticagrelor were associated with better survival than those using clopidogrel in the included studies.
The forensic comparison of trace amounts of soil on a pyjama top with hypersulphidic subaqueous soil from a river as evidence in a homicide cold case
Authors: Fitzpatrick Robert W. , Raven Mark D. 
Published: July 2019

Abstract
In a cold case investigation of a 1983 homicide, trace amounts of soil were identified on a 10-year-old victim's pyjama top. Swatch samples were cut from the pyjama top, specifically the hem, to determine the provenance of this questioned soil. A comparative study was undertaken of the questioned soil with control soils from the Onkaparinga estuary using morphological observations with the naked eye and scanning electron microscopy (SEM), chemistry, traditional laboratory X-ray diffraction (XRD) and synchrotron µ-XRD. Synchrotron µ-XRD with high-intensity X-rays provided greater sensitivity and resolution than the laboratory XRD source to identify pyrite and clay minerals on the pyjama top. SEM confirmed that these mineral particles are deeply impregnated in gaps between fibres of the fabric, which are likely to have originated under water with force being applied on the pyjama top – implying that the victim was pushed into the mud. This is substantiated by transference shaking experiments, where mineral particles are dominantly located on the surface of the fabric. The questioned soil samples have a moderately strong degree of comparability with the control hypersulphidic subaqueous soils containing pyrite in the Onkaparinga River estuary – providing evidence that the soils have similar origins. The accused was found guilty by a Supreme Court judge of murder.
Natural History of Myocardial Injury and Chamber Remodeling in Acute Myocarditis
Authors: White James A. , Hansen Reis , Abdelhaleem Ahmed , Mikami Yoko , Peng Mingkai , Rivest Sandra , Satriano Alessandro , Dykstra Steven , Flewitt Jacqueline , Heydari Bobak , Lydell Carmen P. , Friedrich Matthias G. , Howarth Andrew G. 
Published: July 2019

Background:
Cardiovascular magnetic resonance (CMR) imaging is commonly used to diagnose acute myocarditis. However, the natural history of CMR-based tissue markers and their association with left ventricular recovery is poorly explored. We prospectively investigated the natural history of CMR-based myocardial injury and chamber remodeling over 12 months in patients with suspected acute myocarditis.

Methods:
One hundred patients with suspected acute myocarditis were enrolled. All underwent CMR evaluations at baseline and 12 months, inclusive of T2 and late gadolinium enhancement. Blinded quantitative analyses compared left ventricular chamber volumes, function, myocardial edema, and necrosis at each time point using predefined criteria. The predefined primary outcomes were improvement in left ventricular ejection fraction ≥10% and improvement in the indexed left ventricular end diastolic volume ≥10% at 12 months.

Results:

The mean age was 39.9±14.5 years (82 male) with baseline left ventricular ejection fraction of 57.1±11.2%. A total of 72 patients (72%) showed late gadolinium enhancement at baseline with 57 (57%) having any T2 signal elevation. Left ventricular volumes and EF improved significantly at 12 months. Global late gadolinium enhancement extent dropped from 8.5±9.2% of left ventricular mass to 3.0±5.2% (
P
=0.0001) with prevalence of any late gadolinium enhancement dropping to 48%. Reductions in global T2 signal ratio occurred at 12 months (1.85±0.3 to 1.56±0.2;
P
=0.0001) with prevalence of T2 ratio ≥2.0 dropping to 7%. Neither marker provided associations with the primary outcomes.

Conclusions:
In clinically suspected acute myocarditis, significant reductions in tissue injury markers occur during the first 12 months of convalescence. Neither the presence nor extent of the investigated CMR-based tissue injury markers were predictive of our pre-defined function or remodeling outcomes at 12 months in this referral population.
Changes in the Prescription of Glucose‐Lowering Medications in Patients With Type 2 Diabetes Mellitus After a Cardiovascular Event: A Call to Action From the DATAFILE Study
Authors: Fadini Gian Paolo , Frison Vera , Simioni Natalino , Lapolla Annunziata , Gatti Adriano , Bossi Antonio Carlo , Del Buono Andrea , Fornengo Paolo , Gottardo Lucia , Laudato Mario , Perseghin Gianluca , Bonora Enzo , Avogaro Angelo 
Published: July 2019

Background

Evidence accumulated that some glucose‐lowering medications protect against cardiovascular events (
CVEs
) in patients with type 2 diabetes mellitus (T2DM) and established cardiovascular disease. The present study evaluated if and how glucose‐lowering medication prescription pattern changes in T2DM after a CVE.

Methods and Results

DATAFILE (Diabetes Therapy After a Cardiovascular Event) was a retrospective multicenter study conducted at 12 diabetes mellitus specialist outpatient clinics in Italy. We identified T2DM patients with an incident
CVE
for whom a follow‐up visit was available after the event. We selected control T2DM patients without an incident
CVE
, who were matched with cases for age, sex, known diabetes mellitus duration, baseline hemoglobin A
1c
, kidney function, and follow‐up time. We extracted clinical variables and compared prescribed therapies at baseline and follow‐up. We included 563 patients with and 497 matched patients without an incident
CVE
. As expected, patients with a subsequent
CVE
had a higher baseline prevalence of ischemic heart disease. After a median of 9.5 months, in patients with versus those without a
CVE
, there was a significant increase in the prescription of beta‐blockers, loop diuretics, dual antiplatelet therapy, and, among glucose‐lowering medications, a significant decrease in metformin. Hemoglobin A
1c
marginally declined only in the control group, whereas low‐density lipoprotein cholesterol decreased only in patients with
CVE
.

Conclusions

This study highlights that occurrence of a
CVE
in T2DM patients did not prime the prescription of glucose‐lowering medications provided with cardiovascular protective effects, even though glucose control remained poor. These data emphasize the need to optimize the therapeutic regimen of T2DM patients with established cardiovascular disease, according to updated guidelines.
Long‐Term Risk Stratification of Patients Undergoing Coronary Angiography According to the Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention
Authors: Zafrir Barak , Adawi Salim , Khalaily Marah , Jaffe Ronen , Eitan Amnon , Barnett‐Griness Ofra , Saliba Walid 
Published: July 2019

Background

A risk score for secondary prevention after myocardial infarction (Thrombolysis in Myocardial Infarction Risk Score for Secondary Prevention [TRS2P]), based on 9 established clinical factors, was recently developed from the
TRA
2°P‐
TIMI
50 (Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events) trial. We aimed to evaluate the performance of
TRS
2P for predicting long‐term outcomes in real‐world patients presenting for coronary angiography.

Methods and Results

A retrospective analysis of 13 593 patients referred to angiography for the assessment or treatment of coronary disease was performed. Risk stratification for 10‐year major adverse cardiovascular events was performed using the
TRS
2P, divided into 6 categories (0 to ≥5 points), and in relation to the presenting coronary syndrome. All clinical variables, except prior coronary artery bypass grafting, were independent risk predictors. The annualized incidence rate of major adverse cardiovascular events increased in a graded manner with increasing
TRS
2P, ranging from 1.65 to 16.6 per 100 person‐years (
P
trend
<0.001). Compared with the lowest‐risk group (risk indicators=0), the hazard ratios (95% CIs) for 10‐year major adverse cardiovascular events were 1.60 (95% CI, 1.36–1.89), 2.58 (95% CI, 2.21–3.02), 4.31 (95% CI, 3.69–5.05), 6.43 (95% CI, 5.47–7.56), and 10.03 (95% CI, 8.52–11.81), in those with 1, 2, 3, 4 and ≥5 risk indicators, respectively. Risk gradation was consistent among individual clinical end points.
TRS
2P showed reasonable discrimination with C‐statistics of 0.693 for major adverse cardiovascular events and 0.758 for mortality. The graded relationship between the risk score and event rates was observed in both patients presenting with acute and nonacute coronary syndromes.

Conclusions

The use of
TRS
2P, a simple risk score based on routinely collected variables, enables risk stratification in patients undergoing coronary angiography. Its predictive value was demonstrated in a real‐world setting with long‐term follow‐up and regardless of the acuity of coronary presentation.
How the Sauce Got to be Better than the Fish: Scholarship and Rivalry in Isaac Casaubon’s Studies of Ancient Satire
Authors: De Smet Ingrid A. R. 
Published: July 2019

Isaac Casaubon’s 1605 Persius edition and its companion-piece, the De satyrica Graecorum poesi et Romanorum satira, likewise published in 1605, have long been considered milestones in the history of scholarship on Ancient satire. Marshalling evidence from humanist correspondences, annotated copies of early printed books, manuscripts and visual materials, this study offers a fresh and much fuller and more nuanced view of either book’s trajectory from concept to print and distribution, of the motivations and guiding principles behind Casaubon’s research, and, more generally, of scholarly endeavor around the turn of the seventeenth century. I demonstrate how Casaubon’s work on satire is linked to the humanist recovery of Ancient scholia, how its erudition integrates observations on the contemporary world and non-textual evidence, and how it is marked by fierce scholarly rivalry and – hitherto underestimated – confessional differences.
Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) versus low PEEP on patients with moderate–severe acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials
Authors: Zheng Xi , Jiang Yijia , Jia Huimiao , Ma Wenliang , Han Yue , Li Wenxiong 
Published: July 2019

Background: Setting a positive end-expiratory pressure (PEEP) on patients with acute respiratory distress syndrome (ARDS) receiving mechanical ventilation has been an issue of great contention. Therefore, we aimed to determine effects of lung recruitment maneuver (RM) and titrated PEEP versus low PEEP on adult patients with moderate–severe ARDS. Methods: Data sources and study selection proceeded as follows: PubMed, Ovid, EBSCO, and Cochrane Library databases were searched from 2003 to May 2018. Original clinical randomized controlled trials which met the eligibility criteria were included. To compare the prognosis between the titrated PEEP and low PEEP groups on patients with moderate–severe ARDS (PaO2/FiO2 < 200 mmHg). Heterogeneity was quantified through the I2 statistic. Egger’s test and funnel plots were used to assess publication bias. Results: No difference was found in 28-day mortality and ICU mortality (OR = 0.97, 95% CI (0.61–1.52), p = 0.88; OR = 1.14, 95% CI (0.91–1.43), p = 0.26, respectively). Only ventilator-free days, length of stay in the ICU, length of stay in hospital, and incidence of barotrauma could be systematically reviewed owing to bias and extensive heterogeneity. Conclusion: No difference was observed in the RM between the titrated PEEP and the low PEEP in 28-day mortality and ICU mortality on patients with moderate–severe ARDS.
Predictive Significance of Charcot–Leyden Crystals for Eosinophilic Chronic Rhinosinusitis With Nasal Polyps
Authors: Liu Chang , Yan Bing , Qi Sihan , Zhang Yunyun , Zhang Luo , Wang Chengshuo 
Published: July 2019

Background Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is a distinct phenotype of chronic rhinosinusitis with nasal polyps (CRSwNP), with many significantly different clinical features from non-eosinophilic chronic rhinosinusitis with nasal polyps (non-ECRSwNP). Thus, identification of subtypes is crucial for precise treatment. Immunohistology is a reliable way to present the subtypes; however, the results mainly depend on the observation of pathologist, and the method with automatic readout and the corresponding biomarkers is lacking. Objective The purpose of our research was to explore the predictive value of quantitative reverse transcription polymerase chain reaction (qRT-PCR) as an alternative method and messenger RNA (mRNA) expression of Charcot–Leyden crystals (CLC) as a corresponding target for ECRSwNP, which may benefit the automatized judgment. Method CLC mRNA levels in tissue samples from 48 CRSwNP patients and 10 controls were evaluated by quantitative real-time PCR. Hematoxylin and eosin staining was performed for histological assessment of CRSwNP and subtyping as ECRSwNP and non-ECRSwNP. Factors associated with ECRSwNP were determined with logistic regression analysis, the predictive value was presented by a receiver operating characteristic (ROC) curve, and optimal cutoff points of the predictors were identified as the Youden index. Results mRNA level of CLC in ECRSwNP was significantly elevated compared to either non-ECRSwNP group or control group, with no significant difference between non-ECRSwNP patients and controls. CLC mRNA levels were positively correlated with percentages of tissue eosinophil and peripheral blood eosinophil ( P < .001, r = .683; P = .003, r = .420, respectively). Logistic regression analysis revealed CLC mRNA level and blood eosinophil percentages were prediagnosis factors ( P = .007, P = .045, respectively) for ECRSwNP. ROC curves analysis indicated the area under the curve (AUC) of CLC mRNA level was 0.948 which was superior to the blood eosinophil percentage (AUC = 0.797; P = .044) as an optimal biomarker to predict ECRSwNP. Conclusions CLC mRNA levels based on the qRT-PCR may serve as a reliable and alternative method for the identification of ECRSwNP.
The optimisation of noninvasive ventilation in amyotrophic lateral sclerosis: a systematic review
Authors: O'Brien David , Stavroulakis Theocharis , Baxter Susan , Norman Paul , Bianchi Stephen , Elliott Mark , Johnson Maxine , Clowes Mark , Garcia-Sánchez Aldara , Hobson Esther , McDermott Christopher 
Published: July 2019

BackgroundNoninvasive ventilation (NIV) prolongs survival and quality of life in amyotrophic lateral sclerosis (ALS); however, its benefits depend upon the optimisation of both ventilation and adherence. We aimed to identify factors associated with effective initiation and ongoing use of NIV in ALS to develop evidence-based guidance and identify areas for further research.MethodsWe searched 11 electronic databases (January 1998 to May 2018) for all types of quantitative and qualitative studies. Supplementary grey literature searches were conducted. Records were screened against eligibility criteria, data were extracted from included studies and risk of bias was assessed. We present findings using a narrative synthesis.ResultsWe screened 2430 unique records and included 52 quantitative and six qualitative papers. Factors reported to be associated with NIV optimisation included coordinated multidisciplinary care, place of initiation, selection of interfaces, ventilator modes and settings appropriate for the individual patient, and adequate secretion management. The literature indicated that patients with significant bulbar dysfunction can still derive considerable benefit from NIV if their needs are met. Research emphasises that obstructive airway events, mask leak and uncontrolled secretions should be addressed by adjustments to the interface and machine settings, and the concomitant use of cough augmentation.ConclusionThis review highlights that NIV optimisation requires an individualised approach to respiratory management tailored to the differing needs of each patient. Ultimately, this should lead to improved survival and quality of life. This review expands on recommendations in current international guidelines for NIV use in ALS and identifies areas for future research.
Whitish haze, soapy globules: micro-analysis of degraded burmese paintings on zinc supports
Authors: Chua Lynn 
Published: July 2019

Abstract
Two Burmese oil paintings on zinc supports depicting portraits of royal families, dated to the early 20th century by Saya Aye and Saya Mya, showed interesting corrosion, efflorescence and soapy globules for analytical investigation prior to conservation for exhibition. The features and colours on the two paintings, one of which was in worse condition than the other, were obscured by a whitish haze. Paint rupture and losses due to corrosion of the zinc support were apparent. Using a combination of 3D digital microscopy, FTIR microscopy and SEM–EDS, the degradation, as well as the paint materials and artists’ techniques were analysed and discussed. Zinc soaps, oxalates, silicates, hydroxychlorides, carbonates, wax and mould characterized the haze. Interestingly, brown outlines in Aye’s painting appeared unusually dark. Upon analysis, this degradation phenomenon was attributed to micro-sized greenish soap globules that have developed around copper/zinc (brass) particles, causing the brown outlines to lose their intended luminosity. The other painting by Mya, in which the same brown outline was applied, did not show such formation of globules. Detection of oxalates in the corrosion of zinc support and brown outlines are discussed. This study shows the importance in understanding the artists’ materials and techniques, which have consequential effects to the degradation observed.
Extracellular Matrix–Associated Factors Play Critical Roles in Regulating Pancreatic β-Cell Proliferation and Survival
Authors: Townsend Shannon E , Gannon Maureen 
Published: July 2019

AbstractThis review describes formation of the islet basement membrane and the function of extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for islet transplantation are discussed. The insulin-producing β-cell is key for maintaining glucose homeostasis. The islet microenvironment greatly influences β-cell survival and proliferation. Within the islet, β-cells contact the ECM, which is deposited primarily by intraislet endothelial cells, and this interaction has been shown to modulate proliferation and survival. ECM-localized growth factors, such as vascular endothelial growth factor and cellular communication network 2, signal through specific receptors and integrins on the β-cell surface. Further understanding of how the ECM functions to influence β-cell proliferation and survival will provide targets for enhancing functional β-cell mass for the treatment of diabetes.
The Role of ATP-Binding Cassette Transporters in the Chemoresistance of Anaplastic Thyroid Cancer: A Systematic Review
Authors: Abbasifarid Elnaz , Sajjadi-Jazi Sayed Mahmoud , Beheshtian Maryam , Samimi Hilda , Larijani Bagher , Haghpanah Vahid 
Published: July 2019

AbstractAnaplastic thyroid cancer (ATC) is an aggressive type of thyroid cancer with a high mortality rate. Cytotoxic drugs are among the treatment modalities usually used for ATC treatment. However, systemic chemotherapies for ATC have not been shown to have remarkable efficacy. ATP-binding cassette (ABC) transporters have been suggested as a possible mechanism in ATC resistance to chemotherapy. This systematic review was aimed to define the possible roles of ABC transporters in ATC resistance to chemotherapy. Numerous databases, including Scopus, Web of Science, PubMed, Cochrane Library, Ovid, ProQuest, and EBSCO, were searched for papers published since 1990, with predefined keywords. The literature searches were updated twice, in 2015 and 2017. All identified articles were reviewed, and 14 papers that met the inclusion criteria were selected. In the eligible studies, the roles of 10 out of 49 ABC transporters were evaluated; among them, three pumps (ABCB1, ABCC1, and ABCG2) were the most studied transporters in ATC samples. ABCC1 and ABCG2 had the highest expression rates in ATC, and ABCB1 ranked second among the inspected transporters. In conclusion, ABC transporters are the major determinants of ATC resistance to chemotherapy. By identifying these transporters, we can tailor the best treatment approach for patients with ATC. Additional studies are needed to define the exact role of each ABC transporter and other mechanisms in ATC drug resistance.
Human retinal ganglion cell axon regeneration by recapitulating developmental mechanisms: effects of recruitment of the mTOR pathway
Authors: Teotia Pooja , Van Hook Matthew J. , Fischer Dietmar , Ahmad Iqbal 
Published: July 2019

ABSTRACT
The poor axon regeneration in the central nervous system (CNS) often leads to permanent functional deficit following disease or injury. For example, degeneration of retinal ganglion cell (RGC) axons in glaucoma leads to irreversible loss of vision. Here, we have tested the hypothesis that the mTOR pathway regulates the development of human RGCs and that its recruitment after injury facilitates axon regeneration. We observed that the mTOR pathway is active during RGC differentiation, and using the induced pluripotent stem cell model of neurogenesis show that it facilitates the differentiation, function and neuritogenesis of human RGCs. Using a microfluidic model, we demonstrate that recruitment of the mTOR pathway facilitates human RGC axon regeneration after axotomy, providing evidence that the recapitulation of developmental mechanism(s) might be a viable approach for facilitating axon regeneration in the diseased or injured human CNS, thus helping to reduce and/or recover loss of function.