bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soft tissue sarcoma at the adductor compartment of the thigh may have a greater risk of tumor-associated events and wound complications
Authors: Nakamura Tomoki , Nakamura Koichi , Hagi Tomohito , Asanuma Kunihiro , Sudo Akihiro 
Published: April 2019

Purpose: Soft tissue sarcomas (STSs) of the thigh’s adductor compartment frequently attain a large size before clinical presentation and displace the major neurovascular and lymph structures. We aimed to elucidate the clinical outcome in patients with STS of the thigh’s adductor compartment. Patients and Methods: From March 1999 to June 2016, we treated 24 adult patients with primary STS of the thigh’s adductor compartment. Results: The mean age at diagnosis was 60 years. There were 13 men and 11 women. The mean follow-up period after the date of the initial treatment was 84 months. The mean tumor size at diagnosis was 13.6 cm. The disease-specific survival was 75.3% at 5 years. Local recurrence was detected in seven patients. The 5-year local recurrence-free rate was 69.9%. The patients with proximal STS had significantly poorer local control, compared to the remaining patients. Twelve (50%) patients developed 14 surgical wound complications. Complications included wound dehiscence ( n = 7), infections ( n = 6), lymphorrhea ( n = 1), wound dehiscence and infection ( n = 1), and infection and lymphorrhea ( n = 1). Six patients underwent additional surgical treatment. Intraoperative blood loss and operative time were related to the incidence of wound complications. Intraoperative blood loss and operative time in patients with proximal adductor STS were significantly larger than those in the remaining patients. Conclusion: We should take care of patients with STS of the thigh’s adductor compartment, especially for proximal adductor STS, because they have a greater risk of local recurrence and wound complications.
A Longitudinal Analysis of Total Pain Scores for a Panel of Patients Treated by Pain Clinics
Authors: Wan Thomas T. H. , Gurupur Varadraj , Patel Anand 
Published: April 2019

Background: There is a critical necessity to identify psychometric properties of the total pain score as a measurement of pain management effectiveness in the clinic. Purpose: In this article, we perform the analysis of the global pain scores from a panel of patients treated by 10 pain management physicians in a single group practice. Basic Procedures: The pain measurement consists of 4 pain subscales, namely physical pain, emotions, clinical outcome, and activities. A panel of 130 patients with 4 pain measurements is available to perform longitudinal analysis of the total pain scores. The analysis includes the following: (1) confirmatory factor analysis of the global pain scores with 4 related dimensions, (2) the stability of the pain scores between 2 clinical visits, (3) the change trajectories of pain scores in 4 waves of the pain measurement, and (4) the detection of physician variability in patients’ treatment outcomes measured by the reduction of total pain scores. Main Findings: The global pain scores were relatively stable between time 1 and time 2 clinical visits. The analysis indicated that there was a decrease in pain with longitudinal advancement in treatment. It also indicated that there was no significant change in this improvement with respect to difference in physicians involved in providing treatment. Principal Conclusion: While the results indicated a decrease in pain with an alleviation in treatment provided to the patient, the article delineates a well-thought scientific approach to the targeted problem.
Experiences of an Emergency Department Visit Among Older Adults and Their Families: Qualitative Findings From a Mixed-Methods Study
Authors: Cetin-Sahin Deniz , Ducharme Francine , McCusker Jane , Veillette Nathalie , Cossette Sylvie , Vu T. T. Minh , Vadeboncoeur Alain , Lachance Paul-André , Mah Rick , Berthelot Simon 
Published: April 2019

Background: Emergency department (ED) visits are critical events for older adults, but little is known regarding their experiences, particularly about their physical needs, the involvement of accompanying family members, and the transition back to the community. Objective: To explore experiences of an ED visit among patients aged 75 and older. Methods: In a mixed-methods study, a cohort of patients aged 75 and older (or a family member) discharged from the ED back to the community was recruited from 4 urban EDs. A week following discharge, structured telephone interviews supplemented with open-ended questions were conducted. A subsample (76 patients, 32 family members) was purposefully selected. Verbatim transcripts of responses to the open-ended questions were thematically analyzed. Results: Experiences related to physical needs included comfort, equipment supporting mobility and autonomy, help when needed, and access to drink and food. Family members required opportunities to provide patient support and greater involvement in their care. At discharge, patients/families required adequate discharge education, resolution of their health problem, information on medications, and greater certainty about planned follow-up medical and home care services. Conclusions: Our findings suggest several areas that could be targeted to improve patient and family perceptions of the care at an ED visit.
Inhaled corticosteroids and the risk of lung cancer in COPD: a population-based cohort study
Authors: Raymakers Adam J.N. , Sadatsafavi Mohsen , Sin Don D. , FitzGerald J. Mark , Marra Carlo A. , Lynd Larry D. 
Published: April 2019

Inhaled corticosteroids (ICSs) are often prescribed in patients with chronic obstructive pulmonary disease (COPD). Their impact on the risk of lung cancer, a leading cause of mortality in COPD patients, remains uncertain.Population-based linked administrative data between the years 1997 and 2007 from the province of British Columbia, Canada, were used to evaluate the association between lung cancer risk and ICS use in COPD patients. COPD was defined on the basis of receipt of three COPD-related prescriptions in subjects ≥50 years of age. Exposure to ICS was incorporated into multivariable Cox regression models using several time-dependent methods (“ever” exposure, cumulative duration of use, cumulative dose, weighted cumulative duration of use and weighted cumulative dose).There were 39 676 patients who met the inclusion criteria. The mean±sdage of the cohort was 70.7±11.1 years and 53% were female. There were 994 (2.5%) cases of lung cancer during follow-up. In the reference case analysis (time-dependent “ever” exposure), ICS exposure was associated with a 30% reduced risk of lung cancer (HR 0.70 (95% CI 0.61–0.80)). ICS exposure was associated with a decrease in the risk of lung cancer diagnosis over all five methods of quantifying exposure.This population-based study suggests that ICS use reduces the risk of lung cancer in COPD patients.
Asthma and affective traits in adults: a genetically informative study
Authors: Lehto Kelli , Pedersen Nancy L. , Almqvist Catarina , Lu Yi , Brew Bronwyn K. 
Published: April 2019

Depression, anxiety and high neuroticism (affective traits) are often comorbid with asthma. A causal direction between the affective traits and asthma is difficult to determine; however, there may be a common underlying pathway attributable to shared genetic factors. Our aim was to determine whether a common genetic susceptibility exists for asthma and each of the affective traits.An adult cohort from the Swedish Twin Registry underwent questionnaire-based health assessments (n=23 693) and genotyping (n=15 908). Firstly, questionnaire-based associations between asthma and affective traits were explored. This was followed by genetic analyses: 1) polygenic risk scores (PRS) for affective traits were used as predictors of asthma in the cohort, and 2) genome-wide association results from UK Biobank were used in linkage-disequilibrium score regression (LDSC) to quantify genetic correlations between asthma and affective traits. Analyses found associations between questionnaire-based asthma and affective traits (OR 1.67, 95% CI 1.50–1.86 major depression; OR 1.45, 95% CI 1.30–1.61 anxiety; and OR 1.60, 95% CI 1.40–1.82 high neuroticism). Genetic susceptibility for neuroticism explained the variance in asthma with a dose–response effect; that is, study participants in the highest neuroticism PRS quartile were more likely to have asthma than those in the lowest quartile (OR 1.37, 95% CI 1.17–1.61). Genetic correlations were found between depression and asthma (rg=0.17), but not for anxiety or neuroticism.We conclude that the observed comorbidity between asthma and the affective traits may in part be due to shared genetic influences between asthma and depression (LDSC) and neuroticism (PRS), but not anxiety.
Characterisation of children hospitalised with pneumonia in central Vietnam: a prospective study
Authors: Nguyen Phuong T.K. , Tran Hoang T. , Fitzgerald Dominic A. , Tran Thach S. , Graham Stephen M. , Marais Ben J. 
Published: April 2019

Pneumonia is the most common reason for paediatric hospital admission in Vietnam. The potential value of using the World Health Organization (WHO) case management approach in Vietnam has not been documented.We performed a prospective descriptive study of all children (2–59 months) admitted with “pneumonia” (as assessed by the admitting clinician) to the Da Nang Hospital for Women and Children to characterise their disease profiles and assess risk factors for an adverse outcome. The disease profile was classified using WHO pneumonia criteria, with tachypnoea or chest indrawing as defining clinical signs. Adverse outcome was defined as death, intensive care unit admission, tertiary care transfer or hospital stay >10 days.Of 4206 admissions, 1758 (41.8%) were classified as “no pneumonia” using WHO criteria and only 252 (6.0%) met revised criteria for “severe pneumonia”. The inpatient death rate was low (0.4% of admissions) with most deaths (11 out of 16; 68.8%) occurring in the “severe pneumonia” group. An adverse outcome was recorded in 18.7% of all admissions and 60.7% of the “severe pneumonia” group. Children were hospitalised for a median of 7 days at an average cost of 253 USD per admission. Risk factors for adverse outcome included WHO-classified “severe pneumonia”, age <1 year, low birth weight, previous recent admission with an acute respiratory infection and recent tuberculosis exposure. Breastfeeding, day-care attendance and pre-admission antibiotic use were associated with reduced risk.Few hospital admissions met WHO criteria for “severe pneumonia”, suggesting potential unnecessary hospitalisation and use of intravenous antibiotics. Better characterisation of the underlying diagnosis requires careful consideration.
(Re-) conceptualising vulnerability as a part of risk in global health emergency response: updating the pressure and release model for global health emergencies
Authors: Hammer Charlotte Christiane , Brainard Julii , Innes Alexandria , Hunter Paul R. 
Published: April 2019

AbstractVulnerability has become a key concept in emergency response research and is being critically discussed across several disciplines. While the concept has been adopted into global health, its conceptualisation and especially its role in the conceptualisation of risk and therefore in risk assessments is still lacking. This paper uses the risk concept pioneered in hazard research that assumes that risk is a function of the interaction between hazard and vulnerability rather than the neo-liberal conceptualisation of vulnerability and vulnerable groups and communities. By seeking to modify the original pressure and release model, the paper unpacks the representation or lack of representation of vulnerability in risk assessments in global health emergency response and discusses what benefits can be gained from making the underlying assumptions about vulnerability, which are present whether vulnerability is sufficiently conceptualised and consciously included or not, explicit. The paper argues that discussions about risk in global health emergencies should be better grounded in a theoretical understanding of the concept of vulnerability and that this theoretical understanding needs to inform risk assessments which implicitly used the concept of vulnerability. By using the hazard research approach to vulnerability, it offers an alternative narrative with new perspectives on the value and limits of vulnerability as a concept and a tool.
Miscarriages of justice and expert psychiatric evidence: lessons from criminal appeals in England and Wales
Authors: Hallett Nicholas , Smit Nadine , Rix Keith 
Published: April 2019

SUMMARYMiscarriages of justice occur as a result of unsafe convictions and findings and inappropriate sentences. In cases involving expert psychiatric evidence it is possible that the way evidence is presented by experts or interpreted by the courts has a direct bearing on the case. Using illustrative cases from the Criminal Division of the Court of Appeal, advice is offered to expert psychiatric witnesses on ways to reduce the likelihood of contributing to such miscarriages of justice and on how they may assist in rectifying such miscarriages, should they occur.LEARNING OBJECTIVESAfter reading this article you will be able to:
•understand the place of criminal appeals in the criminal justice system in England and Wales•understand what may go wrong in the provision of psychiatric evidence and how expert psychiatric evidence can assist in the administration of justice•be able to reduce the risk of unsafe convictions and inappropriate sentences when providing expert psychiatric evidence, including for cases referred to the Court of Appeal and the Criminal Cases Review Commission.DECLARATION OF INTERESTNone.
Household economic costs associated with mental, neurological and substance use disorders: a cross-sectional survey in six low- and middle-income countries
Authors: Lund Crick , Docrat Sumaiyah , Abdulmalik Jibril , Alem Atalay , Fekadu Abebaw , Gureje Oye , Gurung Dristy , Hailemariam Damen , Hailemichael Yohannes , Hanlon Charlotte , Jordans Mark J. D. , Kizza Dorothy , Nanda Sharmishtha , Olayiwola Saheed , Shidhaye Rahul , Upadhaya Nawaraj , Thornicroft Graham , Chisholm Dan 
Published: April 2019

BackgroundLittle is known about the household economic costs associated with mental, neurological and substance use (MNS) disorders in low- and middle-income countries.AimsTo assess the association between MNS disorders and household education, consumption, production, assets and financial coping strategies in Ethiopia, India, Nepal, Nigeria, South Africa and Uganda.MethodWe conducted an exploratory cross-sectional household survey in one district in each country, comparing the economic circumstances of households with an MNS disorder (alcohol-use disorder, depression, epilepsy or psychosis) (n= 2339) and control households (n= 1982).ResultsDespite some heterogeneity between MNS disorder groups and countries, households with a member with an MNS disorder had generally lower levels of adult education; lower housing standards, total household income, effective income and non-health consumption; less asset-based wealth; higher healthcare expenditure; and greater use of deleterious financial coping strategies.ConclusionsHouseholds living with a member who has an MNS disorder constitute an economically vulnerable group who are susceptible to chronic poverty and intergenerational poverty transmission.Declaration of interestD.C. is a staff member of the World Health Organization. The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions, policy or views of the World Health Organization.
ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling
Authors: Gkotinakou Ioanna-Maria , Befani Christina , Simos George , Liakos Panagiotis 
Published: April 2019

ABSTRACT
Hypoxia-inducible factor 2 (HIF-2) is a principal component of the cellular response to oxygen deprivation (hypoxia). Its inducible subunit, HIF-2α (also known as EPAS1), is controlled by oxygen-dependent as well as oxygen-independent mechanisms, such as phosphorylation. We show here that HIF-2α is phosphorylated under hypoxia (1% O2) by extracellular signal-regulated protein kinases 1 and 2 (ERK1/2; also known as MAPK3 and MAPK1, respectively) at serine residue 672, as identified by in vitro phosphorylation assays. Mutation of this site to an alanine residue or inhibition of the ERK1/2 pathway decreases HIF-2 transcriptional activity and causes HIF-2α to mislocalize to the cytoplasm without changing its protein expression levels. Localization, reporter gene and immunoprecipitation experiments further show that HIF-2α associates with the exportin chromosomal maintenance 1 (CRM1, also known as XPO1) in a phosphorylation-sensitive manner and identify two critical leucine residues as part of an atypical CRM1-dependent nuclear export signal (NES) neighboring serine 672. Inhibition of CRM1 or mutation of these residues restores nuclear accumulation and activity of HIF-2α lacking the ERK1/2-mediated modification. In summary, we reveal a novel regulatory mechanism of HIF-2, involving ERK1/2-dependent phosphorylation of HIF-2α, which controls its nucleocytoplasmic shuttling and the HIF-2 transcriptional activity.
This article has an associated First Person interview with the first author of the paper.
Responsabilidade social corporativa e elisão fiscal: uma análise de empresas certificadas e não certificadas
Authors: Gonçalves Rodrigo de Souza , Santana Grazielle Tatiane , Catarino João Ricardo , Matos Eduardo Bona Safe de 
Published: April 2019

O estudo visa investigar se empresas certificadas como socialmente responsáveis possuem práticas de elisão fiscais diferenciadas quando comparadas às empresas não certificadas. A amostra tem como base 158 observações de empresas brasileiras entre 2010 e 2014, composta por empresas certificadas pelo índice de sustentabilidade empresarial da BM&FBovespa e grupo de controle de empresas não certificadas. No caso de Portugal, obteve-se um total de 17 observações (2010-2014) de empresas certificadas pelo PSI20. Contudo em razão da heterogeneidade da amostra não foi possível constituir grupo de controle, impossibilitando metodologicamente a constituição da amostra. Os resultados encontrados apontam uma tendência no sentido de que empresas consideradas como socialmente responsáveis realizam menos práticas de elisão fiscal quando comparadas ao grupo de controle. Contudo, observa-se em ambos os grupos práticas de elisão muito semelhantes dada a proximidade dos resultados obtidos pela effective tax rate.
False positives in trans-eQTL and co-expression analyses arising from RNA-sequencing alignment errors
Authors: Saha Ashis , Battle Alexis 
Published: April 2019

Sequence similarity among distinct genomic regions can lead to errors in alignment of short reads from next-generation sequencing. While this is well known, the downstream consequences of misalignment have not been fully characterized. We assessed the potential for incorrect alignment of RNA-sequencing reads to cause false positives in both gene expression quantitative trait locus (eQTL) and co-expression analyses. Trans-eQTLs identified from human RNA-sequencing studies appeared to be particularly affected by this phenomenon, even when only uniquely aligned reads are considered. Over 75% of trans-eQTLs using a standard pipeline occurred between regions of sequence similarity and therefore could be due to alignment errors. Further, associations due to mapping errors are likely to misleadingly replicate between studies. To help address this problem, we quantified the potential for "cross-mapping'' to occur between every pair of annotated genes in the human genome. Such cross-mapping data can be used to filter or flag potential false positives in both trans-eQTL and co-expression analyses. Such filtering substantially alters the detection of significant associations and can have an impact on the assessment of false discovery rate, functional enrichment, and replication for RNA-sequencing association studies.
Transcription factor binding site clusters identify target genes with similar tissue-wide expression and buffer against mutations
Authors: Lu Ruipeng , Rogan Peter K. 
Published: April 2019

Background:The distribution and composition ofcis-regulatory modules composed of transcription factor (TF) binding site (TFBS) clusters in promoters substantially determine gene expression patterns and TF targets. TF knockdown experiments have revealed that TF binding profiles and gene expression levels are correlated. We use TFBS features within accessible promoter intervals to predict genes with similar tissue-wide expression patterns and TF targets using Machine Learning (ML).Methods:Bray-Curtis Similarity was used to identify genes with correlated expression patterns across 53 tissues. TF targets from knockdown experiments were also analyzed by this approach to set up the ML framework. TFBSs were selected within DNase I-accessible intervals of corresponding promoter sequences using information theory-based position weight matrices (iPWMs) for each TF. Features from information-dense clusters of TFBSs were input to ML classifiers which predict these gene targets along with their accuracy, specificity and sensitivity. Mutations in TFBSs were analyzedin silicoto examine their impact on TFBS clustering and predict changes in gene regulation.Results: The glucocorticoid receptor gene (NR3C1), whose regulation has been extensively studied, was selected to test this approach.SLC25A32andTANKexhibited the most similar expression patterns toNR3C1. A Decision Tree classifier exhibited the best performance in detecting such genes, based on Area Under the Receiver Operating Characteristic curve (ROC). TF target gene prediction was confirmed using siRNA knockdown, which was more accurate than CRISPR/CAS9 inactivation. TFBS mutation analyses revealed that accurate target gene prediction required at least 1 information-dense TFBS cluster. Conclusions: ML based on TFBS information density, organization, and chromatin accessibility accurately identifies gene targets with comparable tissue-wide expression patterns. Multiple information-dense TFBS clusters in promoters appear to protect promoters from effects of deleterious binding site mutations in a single TFBS that would otherwise alter regulation of these genes.
Thinking Broad and Deep: Why Some Directors Exert an Outsized Influence on Strategic Change
Authors: Lungeanu Razvan , Zajac Edward J. 
Published: April 2019

This study addresses the oft-debated questions of whether, when, and how corporate board members help shape firm strategy by advancing a new perspective on heterogeneous director influence that introduces the notion of the deep/broad director. Specifically, we take a sociocognitive and sociopolitical perspective on governance to suggest that deep/broad new outside directors, whose expertise results from a blend of depth and breadth of experience, will have an outsized influence in shaping firm strategy. We test our theory using an extensive multiyear data set that tracks all firms that went through an initial public offering in the United States across multiple business cycles (1997, 2001, and 2004) until 2011. Focusing on new outside directors in their first year of service (and controlling for selection issues), our results support our main prediction that those directors whose prior experiences are both deep and broad are the most influential directors for strategic change. We find this result to be robust for multiple indicators of strategic change. We also explore whether the outsized influence of the deep/broad director on strategic change may vary by differences in a board’s openness to strategic change. We conclude by highlighting the relevance of our approach and findings for future research and debates on director selection and director expertise.The supplementary file is available at https://doi.org/10.1287/orsc.2018.1258 .