bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy of Anlotinib Plus Whole Brain Radiotherapy in Advanced Non‐Small Cell Lung Cancer With Multiple Brain Metastases: A Retrospective Study
Authors: Liu Lipin , Xu Yonggang , Gao Hong , Zhao Ting , Chen Dazhi , Jin Jingyi , Gao Cui , Li Gaofeng , Zhong Qiuzi 
Published: December 2024

ABSTRACTPurposeThis study aimed to compare the efficacy of anlotinib plus whole‐brain radiotherapy (WBRT) with that of WBRT alone in non‐small cell lung cancer (NSCLC) patients with multiple brain metastases (BMs).MethodsThe clinical data of patients with NSCLC and multiple BMs who received WBRT between 2019 and 2022 were collected. The patients were assigned to anlotinib plus WBRT group and WBRT group according to the treatment used.ResultsA total of 64 patients were eligible for analysis; 21 were treated with anlotinib plus WBRT, and 43 were treated with WBRT. The anlotinib plus WBRT group had a greater proportion of patients who were young and had a better performance status and adenocarcinoma histology than did the WBRT group. The median follow‐up time was 18.0 months. The median intracranial progression‐free survival (iPFS) was significantly longer in the anlotinib plus WBRT group than in the WBRT group (12.9 months vs. 7.4 months, p = 0.004). The median overall survival (OS) was 14.6 months in the anlotinib plus WBRT group and 9.4 months in the WBRT group (p = 0.039). Considering death as a competing risk to intracranial progression, the 1‐year cumulative incidence of intracranial progression in the anlotinib plus WBRT group (26.7%) was significantly lower than that in the WBRT group (64.3%) (p = 0.021). There was no significant difference in treatment‐related toxicity between the anlotinib plus WBRT group and the WBRT group.ConclusionCompared with WBRT alone, anlotinib plus WBRT might confer superior intracranial PFS for NSCLC patients with multiple BMs without increasing treatment‐related toxicity.
Demanding ownership: Energy democracy and environmental labour geographies
Authors: Paul Franziska Christina 
Published: December 2024

AbstractThis paper contributes an ‘ownership perspective’ to the spectrum of labour environmentalist enquiries, and positions environmental labour geographies within a wider political economy of transformation. The paper explores the concept of energy democracy as a trade union strategy that pursues the social and economic ownership and democratic governance of energy systems and resources. Empirically, the paper presents the case study of Trade Unions for Energy Democracy (TUED), as an ‘actually existing’ initiative of labour environmentalism, contextualising its emergence and enduring relevance in terms of its approach to ownership vis‐à‐vis justice‐oriented demands, and exploring its geographies through a strategy of spatially specific mobilising and regionally focused movement building. The paper investigates how the TUED network has developed a transnational, labour‐inclusive framework of energy democracy as labour environmentalism, by promoting democratic control and the social, public and collective ownership of energy systems and resources as tangible solutions to address the climate emergency. The paper also establishes how the TUED network creates radical geographies of labour environmentalism, through the varied mobilisation of its participating unions in their specific local and regional contexts around actually existing opportunities for policy and political intervention. The paper concludes that the question of ownership is a fundamental one for environmental labour movements and their geographies, and one that shifts the emphasis of labour environmentalist thinking towards the democratisation of labour environmental ownership relations.
To err is human … so how can we prevent all ABO‐incompatible transfusions?
Authors: Dunbar Nancy M. , Kaufman Richard M. 
Published: December 2024

Savin et al. report a retrospective analysis of ABO‐incompatible red cell transfusions in the United Kingdom, France and Germany. In spite of varied strategies for bedside preventative measures, all three countries continue to identify preventable errors leading to ABO‐incompatible red cell transfusions. This report highlights the ongoing challenge of human error as a factor in the persistence of preventable mistransfusions.Commentary on: Savin et al. Frequencies and causes of ABO‐incompatible red cell transfusions in France, Germany and the United Kingdom. Br J Haematol 2025; 206:726‐734.
Islet‐derived exosomal miR‐204 accelerates insulin resistance in skeletal muscle by suppressing sirtuin 1: An in vivo study in a mouse model of high‐fat diet–induced obesity
Authors: Yang Xuehan , Han Hao , Wang Sushan , Teng Fei , Lv Xiaoyan , Zhang Meishuang , Zhang Ying , Li Wei , Zhang Ming , Chen Li , Zhang Siwei 
Published: December 2024

AbstractAims: The interaction between pancreatic islets and skeletal muscle plays a pivotal role in the development of insulin resistance. The present study aimed to elucidate the impact of non‐hormonal molecules from islets on the insulin sensitivity of skeletal muscle cells.Materials and Methods:We developed a mouse model of obesity through a high‐fat diet, assessing glucose tolerance and conducting miRNA sequencing on skeletal muscle samples. An in vitro model was established by treating cells with palmitic acid, and exosomes in the supernatant were characterized using scanning electron microscopy and CD63 expression analysis. Intracellular miR‐204‐5p levels were quantified by RT‐PCR.Results: Our in vivo model demonstrated a robust correlation between miR‐204‐5p level alterations and obesity‐induced insulin resistance. Elevated fatty acid levels were observed to increase miR‐204‐5p in both skeletal muscle and islets. In cellular studies, palmitic acid increased miR‐204‐5p in MIN‐6 islet β‐cells but not in C2C12 skeletal muscle cells. Exosomes containing miR‐204‐5p, secreted by palmitic acid‐treated MIN6 cells, were identified through morphological examination, immunoblotting for the exosomal marker CD63, and intraexosomal miR‐204‐5p level measurement. C2C12 cells were shown to uptake islet‐derived miR‐204‐5p exosomes, as evidenced by the uptake of Exo‐Red labeled exosomes. TargetScan analysis identified a highly conserved binding site for miR‐204‐5p in the 3' UTR of Sirt mRNA. Functional studies indicated that miR‐204‐5p overexpression reduced glucose consumption and uptake in C2C12 cells, decreased Sirt expression, and impaired insulin signaling, as evidenced by reduced Akt phosphorylation and membrane Glut4 levels.Conclusions: Our findings reveal that miR‐204‐5p contributes to the development of insulin resistance in obesity and acts as a signaling molecule in the crosstalk between pancreatic islets and skeletal muscle.
COMT Val158Met polymorphism protects the impact of a mother's history of childhood trauma on emotional and behavioural problems in preschool children
Authors: Xavier Janaína , Bastos Clarissa Ribeiro , Marins Thayane Moreira , Camerini Laísa , Behling De Mello Daniele , Antunes Bruna , de Ávila Quevedo Luciana , de Matos Mariana Bonati , Pinheiro Ricardo Tavares , Ghisleni Gabriele 
Published: December 2024

AbstractChildhood trauma has a well‐established negative impact on mental health outcomes across the lifespan. Cumulative evidence suggests an intergenerational transmission of trauma to descendants. In this way, considering the child's COMT Val158Met (rs4680: G > A) variant, the study aims to investigate the interactive effect of maternal childhood trauma on the emotional/behavioural problems of their offspring in preschoolers age (4–5 and 11 years old) from a population‐based dyad of pregnant adolescent women. The behaviour problems of 310 children were assessed using the Child Behaviour Checklist (CBCL) instrument, and maternal trauma was assessed with the Child Trauma Questionnaire (CTQ) between the 20 to 22° gestational weeks. Maternal childhood trauma increases the risk for all emotional/behavioural problems in the offspring, and no direct association between the child's Val158Met genotypes with emotional/behavioural problems. Interestingly, in moderation analysis adjusted by sex, age and skin colour, children of mothers exposed to childhood trauma, carrying the Val/Met genotype, are less likely to develop externalising (p = .020) and total problems (p = .041) when compared to homozygous (Val/Val and Met/Met). Thus, our findings reinforce evidence on the intergenerational impact of maternal trauma on emotional/behavioural problems and demonstrate that this risk is influenced by the genetic background of the individual, varying according to the functional COMT genotype, which confers a protective profile for the development of externalising and total problems.
Epilepsy surgery in children with operculoinsular epilepsy: Results of a large unicentric cohort
Authors: Kudr Martin , Janca Radek , Jahodova Alena , Belohlavkova Anezka , Ebel Matyas , Bukacova Katerina , Maulisova Alice , Tichy Michal , Liby Petr , Kyncl Martin , Holubova Zuzana , Sanda Jan , Jezdik Petr , Mackova Katerina , Ramos Rivera Gonzalo Alonso , Kopac Luka , Krsek Pavel 
Published: December 2024

AbstractObjectiveEpilepsy surgery in the operculoinsular cortex is challenging due to the difficult delineation of the epileptogenic zone and the high risk of postoperative deficits.MethodsPre‐ and postsurgical data from 30 pediatric patients who underwent operculoinsular cortex surgery at the Motol Epilepsy Center Prague from 2010 to 2022 were analyzed.ResultsFocal cortical dysplasia (FCD; n = 15, 50%) was the predominant cause of epilepsy, followed by epilepsy‐associated tumors (n = 5, 17%) and tuberous sclerosis complex (n = 2, 7%). In eight patients where FCD was the most likely etiology, the histology was negative. Seven patients (23%) displayed normal magnetic resonance imaging results. Seizures exhibited diverse semiology and propagation patterns (frontal, perisylvian, and temporal). The ictal and interictal electroencephalographic (EEG) findings were mostly extensive. Multimodal imaging and advanced postprocessing were frequently used. Stereo‐EEG was used for localizing the epileptogenic zone and eloquent cortex in 23 patients (77%). Oblique electrodes were used as guides for better neurosurgeon orientation. The epileptogenic zone was in the dominant hemisphere in 16 patients. At the 2‐year follow‐up, 22 patients (73%) were completely seizure‐free, and eight (27%) experienced a seizure frequency reduction of >50% (International League Against Epilepsy class 3 and 4). Fourteen patients (47%) underwent antiseizure medication tapering; treatment was completely withdrawn in two (7%). Nineteen patients (63%) remained seizure‐free following the definitive outcome assessment (median = 6 years 5 months, range = 2 years to 13 years 5 months postsurgery). Six patients (20%) experienced corona radiata or basal ganglia ischemia; four (13%) improved to mild and one (3%) to moderate hemiparesis. Two patients (7%) operated on in the anterior insula along with frontotemporal resection experienced major complications: pontine ischemia and postoperative brain edema.SignificanceEpilepsy surgery in the operculoinsular cortex can lead to excellent patient outcomes. A comprehensive diagnostic approach is crucial for surgical success. Rehabilitation brings a great chance for significant recovery of postoperative deficits.
Epilepsy surgery education and practice around the globe: An ILAE taskforce report
Authors: Nico Enslin Johannes M. , Muh Carrie R. , Wang Xiongfei , von Hertwig Fernandes de Olivera Tatiana , McKhann Guy M. , Damisah Eyiyemisi , Al‐Otaibi Faisal , Rydenhag Bertil , Ali Rushna P. , Dorfer Christian , Englot Dario J. , Cukiert Arthur ,   Epilepsy Surgery Education Taskforce of the International League Against Epilepsy
Published: December 2024

AbstractUp to 80% of the world's population with epilepsy lives in low and middle‐income countries. Around one‐third of these patients will have drug‐resistant epilepsy, for which epilepsy surgery is an option. Unfortunately, many of these regions, as well as some more developed nations, lack sufficient epilepsy surgery units and trained neurosurgeons. With this in mind, the International League Against Epilepsy (ILAE) formed the Epilepsy Surgery Education Taskforce to address the shortage of further educational opportunities for surgeons and neurologists and to promote the creation of more epilepsy surgery units around the world. In this article, we publish our findings from a web‐based international survey, in which we investigated the global distribution and experience of neurosurgeons who perform epilepsy surgery, their educational paths, and opinions on the further need for epilepsy surgery education, as well as the resources available to them. We report a detailed analysis of the 202 survey replies received from 35 different countries across six continents. The lack of adequate numbers of epilepsy surgery units in the Southern Hemisphere is notable, and the aim of this task force with other ILAE committees, is to improve access to epilepsy surgery for patients and to enhance training for their health care providers.
Impact of Pleistocene Climate on Diversification and Distribution of Congeneric Freshwater Crustacean Species
Authors: Puli Gislaine , Santos Sandro , Zimmermann Bianca Laís , Gonçalves Alberto Senra , Bartholomei‐Santos Marlise Ladvocat 
Published: December 2024

ABSTRACTAimThe climatic oscillations of the glacial–interglacial cycles significantly influenced species diversification, playing an essential role in shaping the current patterns of biodiversity. However, the effects of the Pleistocene climate on species diversification and their current distribution are poorly understood for the Southern Hemisphere and some taxonomic groups, such as invertebrates. Here, we explore the role of Pleistocene climate changes in the diversification and distribution of four species of South American freshwater crustaceans.LocationSouthern South America.TaxonGenus Aegla (Aeglidae).MethodsWe performed phylogenetic analyses, estimated genetic diversity and neutrality indices for Aegla alacalufi, Aegla neuquensis, Aegla platensis and Aegla uruguayana using nuclear and mitochondrial sequences. We used the mitochondrial genes to estimate divergence times, calculate historical demography and reconstruct the ancestral area range. We also estimated current and past potential distributions using ecological niche modelling.ResultsAlthough all species studied had their diversification influenced by Pleistocene glacial cycles, the Patagonian species A. alacalufi and A. neuquensis, which were directly influenced by the glacial ice cap, appear to have benefited from lower sea levels and melting of glaciation ice. As for the species A. platensis and A. uruguayana, their diversification was affected by the dry and cold climate on the continent during the glacial period.Main ConclusionsOur study unveils the intricate interplay between Pleistocene climatic fluctuations and the evolutionary history of freshwater crustaceans in South America. Distinct phylogeographic patterns were observed in Aegla. Some underwent significant diversification due to glaciation, while the cold, arid conditions of the continent shaped others. These findings underscore the crucial role of past climate dynamics in the distribution and genetic diversity of species. As freshwater ecosystems confront escalating threats, our study highlights the urgency for conservation measures and continued research to unveil species' adaptive mechanisms in the face of climate change.
The Emotional Nature of Malicious and Benign Envy: Separate Measurements for Emotion and Motivation
Authors: Nakai Ayaka , Numazaki Makoto 
Published: December 2024

AbstractMalicious envy causes behavior that lowers an envied person's position, whereas benign envy causes behavior that heightens an envious person's position. We considered that the emotional core of malicious envy might be negative emotion toward the envied person, whereas the emotional core of benign envy might be negative emotion toward the self. To test this idea, we manipulated the causes of another's success (luck vs. effort), which has been shown to be a factor in the occurrence of malicious or benign envy, and examined the influence on emotion and motivation. The results showed that negative emotion toward an envied person mediated the effect that participants in the luck condition experienced stronger motivation aimed at pulling the envied person's position down than those in the effort condition. The results also demonstrated that negative emotion toward the self mediated the effect that participants in the effort condition felt stronger motivation aimed at improving their own situation than those in the luck condition. These results supported our idea about the core emotions of malicious and benign envy.
Rapid and sensitive detection of Pseudomonas syringae pv. actinidiae causing bacterial canker of kiwifruit using recombinase‐aided amplification with lateral flow dipstick assay
Authors: Liu Hailong , Chen Shasha , Peng Lan , Liu Wei , Xu Liangsheng , Huang Lili 
Published: December 2024

AbstractBacterial canker of kiwifruit, caused by Pseudomonas syringae pv. actinidiae (Psa), is a highly destructive disease that results in significant economic losses. Timely detection of Psa is essential for implementing effective disease control measures. In this study, a recombinase‐aided amplification with lateral flow dipstick (RAA‐LFD) assay targeting the type III effector avirulence D1 (AvrD1) gene was developed. The assay was optimized for reaction conditions to ensure a swift and accurate detection protocol suitable for field application. In tandem, conventional PCR was also selected for comparison with the RAA‐LFD assay. The RAA‐LFD assay demonstrated a detection limit of 1 pg/μL for genomic DNA and 104 cfu/mL cell suspension. Specificity testing confirmed that the assay exclusively targeted Psa without cross‐reactivity with other endophytic bacteria present in kiwifruit. To validate the RAA‐LFD assay, it was compared with the conventional PCR method using 56 field samples. The results from both methods were found to be in complete agreement, validating the RAA‐LFD as a reliable diagnostic tool. Therefore, the established Psa RAA‐LFD assay provided technical support for the early and accurate diagnosis of bacterial canker in kiwifruit, which is crucial for disease management and prevention strategies.
Ulnar–Basilic Arteriovenous Fistula for Hemodialysis: A 15‐Year Overview
Authors: Sirvent Ana Esther , Vigueras‐Hernández María Rosa , Enríquez Ricardo , Pérez‐Abad Juan Mariano , Pérez‐Pérez Antonio , Ruiz‐Merino Guadalupe , Andreu‐Muñoz Alberto J. 
Published: December 2024

ABSTRACTIntroductionDistal forearm arteriovenous fistulas (AVFs) for hemodialysis (HD) include radiocephalic fistulas (RCFs) and ulnar–basilic fistulas (UBFs). However, due to the unique anatomical peculiarities of the latter approach, UBFs are only established in a limited subset of patients undergoing vascular access procedures. This study aimed to present a retrospective case series detailing the creation of UBFs, emphasizing both the technical challenges and clinical outcomes associated with this approach.MethodsWe conducted a retrospective review of UBFs created between 2008 and 2023. Data collected included patient demographics, comorbidities, patency, functionality, and outcomes. Adequate blood flow and personalized Kt/Vurea levels were prerequisites for defining UBF functionality for HD.ResultsAmong 253 patients receiving HD, 82.2% had an AVF, with only 3.3% (n = 5) of the 150 distal AVFs functional for HD being UBFs. In this series, a total of 11 UBF fistulas were created, with nine patients experiencing an immediate thrill. Among those with UBF failure, three patients were aged > 85 years, and three had concurrent diabetes mellitus, peripheral vascular disease, and ischemic heart disease. The survival rate in the UBF group correlated with the duration of dialysis in the three patients for whom the UBF was the sole AVF, with one patient achieving a remarkably prolonged period of > 10 years. No incidences of ischemia, hand edema, or ulnar nerve lesions were noted.ConclusionWhile the difficulties experienced in achieving functional UBFs for HD are highlighted in this long‐term perspective, its safety and durability make it a viable option in managing an increasingly comorbid patient population.
miR158a negatively regulates plant resistance to Phytophthora parasitica by repressing AtTN7 that requires EDS1‐PAD4‐ADR1 complex in Arabidopsis thaliana
Authors: Li Yilin , Gou Xiuhong , Ma Ruize , Zhang Peiling , Ansabayeva Assiya , Shi Qingyao , Liu Zeming , Meng Yuling , Shan Weixing 
Published: December 2024

SUMMARYSmall RNAs are involved in diverse cellular processes, including plant immunity to pathogens. Here, we report that miR158a negatively regulates plant immunity to the oomycete pathogen Phytophthora parasitica in Arabidopsis thaliana. By performing real‐time quantitative PCR, transient expression, and RNA ligase‐mediated 5′ rapid amplification of cDNA ends assays, we demonstrate that miR158a downregulates AtTN7 expression by cleaving its 3′‐untranslated region. AtTN7 positively affects plant immunity and encodes a truncated intracellular nucleotide‐binding site and leucine‐rich repeat receptor containing the Toll/interleukin‐1 receptor. AtTN7 can degrade oxidized forms of nicotinamide adenine dinucleotide (NAD+). Further genetic and molecular analyses reveal that the Enhanced Disease Susceptibility 1‐Phytoalexin Deficient 4‐Activated Disease Resistance 1 complex is required for AtTN7‐mediated immunity. ADR1‐dependent Ca2+ influx is crucial for activating salicylic acid signaling to condition AtTN7‐triggered immunity. Our study uncovers the immune roles and regulatory mechanisms of miR158a and its target AtTN7. Both miR158a‐downregulation and AtTN7‐overexpression lead to enhanced plant resistance to P. parasitica without affecting plant growth phenotypes, suggesting their application potentials and the utilization of miRNAs in identifying novel immune genes for the development of plant germplasm resources with enhanced disease resistance.
Superhydrophobic Property and Corrosion Resistance of 1100 Aluminum Alloy With Peano Fractal Micro-Nano Textures
Authors: Ding Cong , Qiao Zhizhao , Piao Zhongyu 
Published: December 2024

Abstract
To enhance the corrosion resistance of aluminum alloy exposed to marine environment, a novel Peano fractal micro-nano texture was introduced. The Peano micro-nano textures with three depths were prepared by laser etching technology, and the textured surfaces were modified using an ethanol solution of 1H, 1H, 2H, 2H-perfluorodecyltriethoxysilane (PFDS). The hydrophobic properties of aluminum alloy surfaces with Peano textures were measured. The wetting mechanism was analyzed via X-ray photoelectron spectroscopy (XPS) characterization, and the electrochemical experiments were performed to explore the corrosion resistance of a superhydrophobic surface. The results showed that LS-d30 (laser processed specimen with depth of 30 μm) exhibited the optimal superhydrophobicity, with a water contact angle of 169.3 deg and a sliding angle of 3.9 deg. The Peano micro-nano texture facilitated the adsorption of PFDS, resulting in the creation of CF2–CF2 and CF3–CF3 functional groups on the surface. These functional groups contributed to the enhancement of hydrophobic properties. The LS-d30 surface exhibited a superior corrosion inhibition rate of 84.16%. Additionally, electrochemical impedance spectroscopy (EIS) revealed a significant increase in the corrosion resistance of the Peano fractal micro-nano texture surface.