bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relation Between Family Quality of Life and the Family‐Centered Approach in Families With Children With an Intellectual Disability
Authors: Vanderkerken Lien , Heyvaert Mieke , Onghena Patrick , Maes Bea 
Published: August 2019

AbstractAlthough family quality of life (FQOL) and the family‐centered approach (FCA) are often conceptually linked, empirical research on their relation is scarce. This study investigated the relation between the FCA and FQOL in families with a child (0–18 years) with an intellectual disability receiving home‐based support (HBS) in Flanders. The impact of the parental work situation and the child's support needs on FQOL (domains) were studied too. Through the Helpgiving Practices Scale (HPS) and the Enabling Practices Scale (EPS), parents of participating families (n = 58) reported about the FCA in their families' HBS. Using the Beach Center FQOL Scale, mainly mothers reported about their families' quality of life. The relation between the realization of the FCA, parental employment, and the child's support needs on the one hand, and FQOL on the other hand was studied via multiple regression analyses. Additionally, the best predicting model was determined for FQOL (domains). Globally, a positive relation between FQOL and the FCA was found. Dependent on the FQOL domain, a different relation was identified with the family‐centered components. Components of the EPS (i.e., comfort and parental autonomy) were better predictors than those of the HPS. The parental work situation was a significant predictor for satisfaction regarding total FQOL (with and without disability‐related support), family interactions, and parenting. The child's support needs were a significant predictor for emotional well‐being. As the first of its kind, this study investigated the relation between FQOL and the FCA in detail. More, in depth, and especially long‐term research is, however needed to fully understand the relation between FQOL and its contributors.
Exploring Australian parents’ knowledge and awareness of pediatric inpatient falls: A qualitative study
Authors: Shala Danielle Ritz , Brogan Frances , Cruickshank Marilyn , Kornman Kelly , Sheppard‐Law Suzanne 
Published: August 2019

AbstractPurposeWhile there has been extensive published research into adult inpatient falls, less is known about pediatric falls in Australia. Falls pose a safety risk to pediatric patients potentially causing harm, increased length of stay, and death. Parents play a central role in reducing falls‐related incidents given that, as parents, they provide care and/or oversee care delivered to their child at the bedside. Developing a better understanding of what parents and carers know about falls and associated risks, particularly those hospital‐naïve, is central to developing family centered strategies and targeted education to meet the needs of parents. Our study aimed to explore Australian parents’ knowledge and awareness of pediatric inpatient falls.DesignQualitative methods utilizing descriptive thematic analysis.MethodsParents of children and/or young people hospitalized during the last 6 months were eligible to participate. Potential participants attending the outpatient clinics of two tertiary pediatric outpatient clinics hospitals in Sydney, Australia were invited to participate in the study. Willing participants consented to complete a face to face in‐depth interview. Open‐ended questions sought to explore participants’ knowledge, knowledge acquisition, and awareness of inpatient falls. Interviews were digitally recorded and transcribed verbatim. Data familiarization and open coding were completed by researchers independently. Researchers explored and discussed emerging categories until patterns emerged and a consensus of dominant themes were agreed upon.ResultsInterviews were conducted with mothers (n = 17), fathers (
n = 4), or both parents together (n = 2) of a child or a young person who had been recently hospitalized. Four dominant themes emerged from the data namely: Supervision: falls won't happen, unexpected, parent priorities, and ways of learning about inpatient falls and risks. Despite parents' awareness of falls risk, parents were unaware that falls occur within a hospital setting and did not prioritize “falls prevention” during admission.Practice implicationsFindings have implications for nursing practice, particularly in the delivery, content, and timing of falls prevention education.
Parental emotional and hands‐on work—Experiences of parents with a newborn undergoing congenital heart surgery: A qualitative study
Authors: Thomi Mirjam , Pfammatter Jean‐Pierre , Spichiger Elisabeth 
Published: August 2019

AbstractPurposeTo explore both mothers’ and fathers’ experiences from prenatal or postnatal diagnosis of their newborn's congenital heart disease (CHD) to the first discharge after heart surgery in a Swiss university children's hospital.Design and MethodA qualitative research approach, based on a constructivist paradigm, was applied to explore participants’ experiences and perceptions. Parents of nine children with moderate to severe CHD participated in semistructured joint couple interviews. Data were analyzed inductively via an iterative process, following the steps of thematic analysis.ResultsBetween the child's CHD diagnosis and hospital discharge after neonatal cardiac surgery, the overarching theme for parents was being confronted with demanding emotional and hands‐on work. This parental work included four themes with subthemes: Parents had to tackle a route through an unknown hospital world from receiving the CHD diagnosis and experiencing delivery to attending to their child in the pediatric intensive care unit and during surgery, as well as during the transfer to and the stay on the pediatric cardiac unit. They experienced an at times challenging interplay with health care professionals, performed teamwork as the nuclear family and managed concerned relatives and friends.Practice ImplicationsHealth care professionals should establish trustful relationships with parents, while accompanying families continuously, providing consistent, straightforward information, and expressing appreciation for the parents’ exceptional emotional and hands‐on work. Health care professionals’ awareness of parent's experiences is vital to compassionate family‐centered care.
Why health professions education needs functional linguistics: the power of ‘stealth words’
Authors: Konopasky Abigail , Ramani Divya , Ohmer Megan , Durning Steven J , Artino Anthony R , Battista Alexis 
Published: August 2019

ContextLanguage is one of the primary modalities for teaching and learning in the health professions in contexts ranging from the more formal teaching relationships of medical school to the guided practice of trainees through continuing education and the deliberate practice of lifelong learning. Yet linguistic analysis, with the possible exception of discourse analysis, has not become a core methodological tool in the field of health professions education (HPE). The purpose of this paper is to argue for the more widespread adoption of one particular approach to linguistics, one that examines less of what learners and instructors say and looks more at how they say it: functional linguistics.Functional linguistics: the power of ‘stealth words’This approach theorises and structures the functions of language, regularly focusing attention on ‘stealth words’ such as I, but and was. Drawing on a rich body of literature in linguistics, psychology, the learning sciences and some early work in HPE, we demonstrate how functional linguistic tools can be applied to better understand learners’ and instructors’ beliefs, reasoning processes, values and emotions.Functional linguistics and reflection: an application of stealth wordsA brief qualitative analysis of one tool – analysis of the generic use of ‘you’ to mean ‘one’ or ‘anyone’ – demonstrates how functional linguistics can offer insight into physicians’ bids for credibility and alignment as they think aloud about their clinical reasoning.Functional linguistics and hpe: future directionsFinally, we offer suggestions for how functional linguistic tools might address questions and gaps in four active research areas in HPE: reflection; emotion and reasoning; learning in simulated contexts, and self‐regulated learning.ConclusionsWe argue that the words used by learners, instructors and practitioners in the health professions as they move through undergraduate and graduate training into practice can offer clues that will help researchers, instructors and colleagues to better support them.
Geophytism in monocots leads to higher rates of diversification
Authors: Howard Cody Coyotee , Landis Jacob B. , Beaulieu Jeremy M. , Cellinese Nico 
Published: August 2019

Summary

Geophytes, plants with buds on underground structures, are found throughout the plant tree of life. These below ground structures allow plants to inhabit highly seasonal and disturbance‐prone environments across ecosystems. Past researchers have hypothesised that the bulbous, cormous and tuberous habits promote diversification, but this had yet to be tested.

Using a comprehensive monocot data set of almost 13 000 taxa, we investigated the effects of the geophytic habit on diversification using both state‐dependent and state‐independent models.

We found that geophytes exhibit increased rates of diversification relative to nongeophytes. State‐dependent analyses recovered higher yet similar rates of diversification for bulbous, cormous and tuberous taxa compared with rhizomatous and nongeophytic taxa. However, the state‐independent model returned no difference in rates among the different traits.

Geophytism shows higher rates of diversification relative to nongeophytes but we found little support for the hypothesis that the evolution of the bulb, corm or tuber appears to provide a diversification increase relative to rhizomatous and nongeophytic taxa. Our broad‐scale analysis highlights the overall evolutionary importance of the geophytic habit (i.e. belowground bud placement). However, our results also suggest that belowground morphological diversity alone cannot explain this rate increase. In order to further test the evolutionary significance of these underground structures, future studies should consider these in combination with other biotic and abiotic factors.
The effect of Public Health/Pediatric Obesity interventions on socioeconomic inequalities in childhood obesity: A scoping review
Authors: Venturelli Francesco , Ferrari Francesca , Broccoli Serena , Bonvicini Laura , Mancuso Pamela , Bargellini Annalisa , Giorgi Rossi Paolo 
Published: August 2019

SummaryChildhood obesity has a strong social gradient. This scoping review aims to synthesize the evidence on the impact on inequalities of non‐targeted interventions to reduce the prevalence of childhood and adolescent obesity in high‐income countries. We updated a review by Hillier‐Brown, searching up to 31 December 2017 on MEDLINE, Embase, The Cochrane Library, CINAHL, and PsycINFO, with no limitations on study design. Fifty‐eight studies describing 51 interventions were included: 31 randomized clinical trials and 27 non‐randomized trials, with sample sizes from 67 to 2,700,880 subjects. The majority were implemented in the school setting at a community level; the others were in health services or general population setting and targeting individuals or the system. Twenty‐nine interventions proved to be effective overall; seven others had an effect only in a subgroup, while 15 proved not to be effective. All types of included interventions can increase inequalities. Moreover, some interventions had opposite effects based on the socioeconomic characteristics. Any kind of intervention can reduce equity. Consequences are difficult to predict based on intervention construct. Complex interventions acting on multiple targets, settings, and risk factors are more effective and have a lower risk of increasing inequalities.
A person‐centred team approach targeting agitated and aggressive behaviour amongst nursing home residents with dementia using the Senses Framework
Authors: Gillis Katrin , Lahaye Hilde , Dom Stijn , Lips Dirk , Arnouts Heidi , Van Bogaert Peter 
Published: August 2019

AbstractPurposeThe increase in agitated or aggressive behaviour amongst nursing home residents with dementia is a challenging problem. Such behaviour causes stress for both resident and caregiver. Many non‐pharmacological interventions have been studied, but these interventions disregard the resident's unfulfilled needs and are executed by a single, designated caregiver. This study tests a non‐pharmacological intervention, applied by the entire team and based on the resident's underlying needs.DesignA pretest and post‐test interventional study design was used, in which 65 residents with dementia who expressed agitated or aggressive behaviour. Data were collected from December 2016 until March 2017.MethodsThe ABC method and the Senses Framework were used to assign residents to either therapeutic touch, group music sessions or a meaningful individual activity. All staff members applied the interventions. Data were collected by use of the Neuropsychiatric Inventory‐Nursing Home version (NPI‐NH) and the Cohen‐Mansfield Agitation Inventory (CMAI).ResultsThe frequency of aggression, loss of decorum, depression and the severity of aggression decreased for all three interventions. However, the overall severity of fear also increased. The overall prevalence of agitated of residents decreased for the therapeutic touch, group music sessions and individual activities.ConclusionsThis study shows the possibilities of designing individualised interventions on the Senses Framework and the ABC method for addressing agitated and aggressive behaviour amongst nursing home residents with dementia. The framework presented in this study should be further explored.Implications for practiceA team‐based approach is effective to reduce agitated or aggressive behaviour amongst nursing home residents.
Simplified adenine base editors improve adenine base editing efficiency in rice
Authors: Hua Kai , Tao Xiaoping , Liang Weiyi , Zhang Zhaoxia , Gou Runyu , Zhu Jian‐Kang 
Published: August 2019

SummaryAdenine base editors (ABEs) have been exploited to introduce targeted adenine (A) to guanine (G) base conversions in various plant genomes, including rice, wheat and Arabidopsis. However, the ABEs reported thus far are all quite inefficient at many target sites in rice, which hampers their applications in plant genome engineering and crop breeding. Here, we show that unlike in the mammalian system, a simplified base editor ABE‐P1S (Adenine Base Editor‐Plant version 1 Simplified) containing the ecTadA*7.10‐nSpCas9 (D10A) fusion has much higher editing efficiency in rice compared to the widely used ABE‐P1 consisting of the ecTadA‐ecTadA*7.10‐nSpCas9 (D10A) fusion. We found that the protein expression level of ABE‐P1S is higher than that of ABE‐P1 in rice calli and protoplasts, which may explain the higher editing efficiency of ABE‐P1S in different rice varieties. Moreover, we demonstrate that the ecTadA*7.10‐nCas9 fusion can be used to improve the editing efficiency of other ABEs containing SaCas9 or the engineered SaKKH‐Cas9 variant. These more efficient ABEs will help advance trait improvements in rice and other crops.
Genome‐wide expression quantitative trait locus analysis in a recombinant inbred line population for trait dissection in peanut
Authors: Huang Li , Liu Xia , Pandey Manish K. , Ren Xiaoping , Chen Haiwen , Xue Xiaomeng , Liu Nian , Huai Dongxin , Chen Yuning , Zhou Xiaojing , Luo Huaiyong , Chen Weigang , Lei Yong , Liu Kede , Xiao Yingjie , Varshney Rajeev K. , Liao Boshou , Jiang Huifang 
Published: August 2019

SummaryThe transcriptome connects genome to the gene function and ultimate phenome in biology. So far, transcriptomic approach was not used in peanut for performing trait mapping in bi‐parental populations. In this research, we sequenced the whole transcriptome in immature seeds in a peanut recombinant inbred line (RIL) population and explored thoroughly the landscape of transcriptomic variations and its genetic basis. The comprehensive analysis identified total 49 691 genes in RIL population, of which 92 genes followed a paramutation‐like expression pattern. Expression quantitative trait locus (eQTL) analysis identified 1207 local eQTLs and 15 837 distant eQTLs contributing to the whole‐genome transcriptomic variation in peanut. There were 94 eQTL hot spot regions detected across the genome with the dominance of distant eQTL. By integrating transcriptomic profile and annotation analyses, we unveiled a putative candidate gene and developed a linked marker InDel02 underlying a major QTL responsible for purple testa colour in peanut. Our result provided a first understanding of genetic basis of whole‐genome transcriptomic variation in peanut and illustrates the potential of the transcriptome‐aid approach in dissecting important traits in non‐model plants.
Symplastic hemangioma developing over an infantile hemangioma during propranolol treatment
Authors: Downey Camila , Pino Guillermo , Zambrano María José , Kramer Daniela , Cervilla Katari , González Sergio 
Published: August 2019

AbstractWe describe a case of a 6‐month‐old female patient with a segmental, superficial, infantile hemangioma (IH) on the forehead being treated with propranolol 2 mg/kg/d for 5 months, who developed a symplastic hemangioma (SH) over the preexisting lesion, highlighting the need to consider SH in the differential diagnosis of vascular lesions arising over preexisting vascular anomalies in children.
Recalcitrant granulomatous periorificial dermatitis with good response to low‐dose oral isotretinoin
Authors: Rodriguez‐Garijo Nuria , Querol‐Cisneros Elena , Tomas‐Velazquez Alejandra , Estenaga Angela , Moreno‐Artero Ester , Idoate Miguel Angel , Paricio Jose Joaquín , España Agustin 
Published: August 2019

AbstractGranulomatous periorificial dermatitis is a clinical variant of periorificial dermatitis. We present the case of an 18‐year‐old girl with several reddish papular lesions in the perioral, perinasal, and periorbital regions unresponsive to conventional therapy. After 6 months of therapy with low‐dose oral isotretinoin, the lesions fully remitted.
Active BR signalling adjusts the subcellular localisation of BES1/HSP90 complex formation
Authors: Samakovli D. , Roka L. , Plitsi P.‐K. , Kaltsa I. , Daras G. , Milioni D. , Hatzopoulos P. 
Published: August 2019

Abstract

Heat shock proteins 90 (HSP90) are essential and play critical roles in the adaptation of organisms to diverse stimuli. In plants, HSP90 are involved in auxin, jasmonate and brassinosteroid (BR) signalling pathways. The BR‐promoted activation of the BES1 transcription factor regulates BR‐responsive genes.

Using genetic, physiological, fluorescence live cell imaging, molecular and biochemical approaches, such as phenotypic analysis, co‐immunoprecipitation assay, yeast‐two hybrid and Bimolecular fluorescence complementation (BiFC), we studied complex formation between BES1 and HSP90 under control conditions and active BR signalling. Further, we determined the effect of the pharmacological inhibition of HSP90 ATPase activity on hypocotyl elongation of bes1-D mutant.

We determined that HSP90 interact with BES1 in the nucleus and in the cytoplasm. During active BR signalling, nuclear complexes were absent while cytoplasmic HSP90/BES1 complexes were prominent. Our results showed that the hypocotyl length of bes1‐D mutants was highly reduced when HSP90 was challenged by the geldanamycin (GDA) inhibitor of the ATPase activity of HSP90. Active BR signalling could not rescue the GDA effect on the hypocotyl elongation of bes1-D.

Our results reveal that the constitutively active BES1 in the bes1‐D mutant is hypersensitive to GDA. The interaction of HSP90 with BES1 argues that HSP90 facilitate the nuclear metastable conformation of BES1 to regulate BR‐dependent gene expression, and our data show that HSP90 assist in the compartmentalised cycle of BES1 during active BR signalling.
Alien worlds, alien laws, and the Humean conceivability argument
Authors: Chan Lok‐Chi , Braddon‐Mitchell David , Latham Andrew James 
Published: August 2019

AbstractMonism is our name for a range of views according to which the connection between dispositions and their categorical bases is intimate and necessary, or on which there are no categorical bases at all. In contrast, Dualist views hold that the connection between dispositions and their categorical bases is distant and contingent. This paper is a defence of Monism against an influential conceivability argument in favour of Dualism. The argument suggests that the apparent possibility of causal behaviour coming apart from categorical bases is best explained by Dualism. We argue that Monism can explain the apparent possibility as well, if we take metaphysically alien laws – namely, laws whose metaphysical nature is alien to the actual world – into account.
Evaluation of Multicriteria Decision Analysis Algorithms in Food Safety: A Case Study on Emerging Zoonoses Prioritization
Authors: Garre Alberto , Boué Geraldine , Fernández Pablo S. , Membré Jeanne‐Marie , Egea Jose A. 
Published: August 2019

AbstractDecision making in food safety is a complex process that involves several criteria of different nature like the expected reduction in the number of illnesses, the potential economic or health‐related cost, or even the environmental impact of a given policy or intervention. Several multicriteria decision analysis (MCDA) algorithms are currently used, mostly individually, in food safety to rank different options in a multifactorial environment. However, the selection of the MCDA algorithm is a decision problem on its own because different methods calculate different rankings. The aim of this study was to compare the impact of different uncertainty sources on the rankings of MCDA problems in the context of food safety. For that purpose, a previously published data set on emerging zoonoses in the Netherlands was used to compare different MCDA algorithms: MMOORA, TOPSIS, VIKOR, WASPAS, and ELECTRE III. The rankings were calculated with and without considering uncertainty (using fuzzy sets), to assess the importance of this factor. The rankings obtained differed between algorithms, emphasizing that the selection of the MCDA method had a relevant impact in the rankings. Furthermore, considering uncertainty in the ranking had a high influence on the results. Both factors were more relevant than the weights associated with each criterion in this case study. A hierarchical clustering method was suggested to aggregate results obtained by the different algorithms. This complementary step seems to be a promising way to decrease extreme difference among algorithms and could provide a strong added value in the decision‐making process.
The pipeline of antiviral T‐cell therapy: what's in the clinic and undergoing development
Authors: Fatic Alyssa , Zhang Nan , Keller Michael D. , Hanley Patrick J. 
Published: August 2019

KEY IDEAS
Virus‐specific T cells allow targeting of multiple pathogens in patients after hematopoietic stem cell transplantation and have demonstrated potential efficacy for cytomegalovirus, Epstein–Barr Virus, and adenovirus.
Novel targets may include BK virus, JC virus, varicella zoster virus, human herpesvirus 6, Aspergillus, human parainfluenza virus‐3, herpes simplex virus Type I, Zika virus, and mycobacteria.
Generation of patient‐specific products and third‐party products may expand feasibility of therapy.