bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Brain Connectivity Alternation Detection via Matrix-variate Differential Network Model
Authors: Ji Jiadong , He Yong , Xie Lei 
Published: October 2018

AbstractMotivationNowadays brain connectivity analysis has attracted tremendous attention and has been at the foreground of neuroscience research. Brain functional connectivity reveals the synchronization of brain systems through correlations in neurophysiological measures of brain activity. Growing evidence now suggests that the brain connectivity network experiences alternations with the presence of numerous neurological disorders, thus differential brain network analysis may provides new insights into disease pathologies. For the matrix-valued data in brain connectivity analysis, existing graphical model estimation methods assume a vector normal distribution that in essence requires the columns of the matrix data to be independent. It is obviously not true, they have limited applications. Among the few solutions on graphical model estimation under a matrix normal distribution, none of them tackle the estimation of differential graphs across different populations. This motivates us to consider the differential network for matrix-variate data to detect the brain connectivity alternation.ResultsThe primary interest is to detect spatial locations where the connectivity, in terms of the spatial partial correlation, differ across the two groups. To detect the brain connectivity alternation, we innovatively propose a Matrix-Variate Differential Network (MVDN) model. MVDN assumes that the matrix-variate data follows a matrix-normal distribution. We exploit the D-trace loss function and a Lasso-type penalty to directly estimate the spatial differential partial correlation matrix where the temporal information is fully excavated. We propose an ADMM algorithm for the Lasso penalized D-trace loss optimization problem. We investigate theoretical properties of the estimator. We show that under mild and regular conditions, the proposed method can identify all differential edges accurately with probability tending to 1 in high-dimensional setting where dimensions of matrix-valued data p, q and sample size n are all allowed to go to infinity. Simulation studies demonstrate that MVDN provides more accurate differential network estimation than that achieved by other state-of-the-art methods. We apply MVDN to Electroencephalography (EEG) dataset, which consists of 77 alcoholic individuals and 45 controls. The hub genes and differential interaction patterns identified are consistent with existing experimental studies.Contactheyong@sdufe.edu.cnSupplementary informationSupplementary data are available online.
A protein-RNA interaction atlas of the ribosome biogenesis factor AATF
Authors: Kaiser Rainer W. J. , Ignarski Michael , Van Nostrand Eric L. , Frese Christian , Jain Manaswita , Cukoski Sadrija , Heinen Heide , Schaechter Melanie , Seufert Lisa , Bunte Konstantin , Frommolt Peter , Keller Patrick , Helm Mark , Bohl Katrin , Höhne Martin , Schermer Bernhard , Benzing Thomas , Höpker Katja , Dieterich Christoph , Yeo Gene W. , Müller Roman-Ulrich , Fabretti Francesca 
Published: October 2018

ABSTRACTAATF is a central regulator of the cellular outcome upon p53 activation, a finding that has primarily been attributed to its function as a transcription factor. Recent data showed that AATF is essential for ribosome biogenesis and plays a role in rRNA maturation. AATF has been implicated to fulfil this role through direct interaction with rRNA and was identified in several RNA-interactome capture experiments. Here, we provide a first comprehensive analysis of the RNA bound by AATF using CLIP-sequencing. Interestingly, this approach shows predominant binding of the 45S pre-ribosomal RNA precursor molecules. Furthermore, AATF binds to mRNAs encoding for ribosome biogenesis factors as well as snoRNAs. These findings are complemented by an in-depth analysis of the protein interactome of AATF containing a large set of proteins known to play a role in rRNA maturation with an emphasis on the protein-RNA-complexes known to be required for the generation of the small ribosomal subunit (SSU). In line with this finding, the binding sites of AATF within the 45S rRNA precursor localize in close proximity to the SSU cleavage sites. Consequently, our multilayer analysis of the protein-RNA interactome of AATF reveals this protein to be an important hub for protein and RNA interactions involved in ribosome biogenesis.
Survival cost to relocation does not reduce population self-sustainability in an amphibian
Authors: Cayuela Hugo , Gillet Lilly , Laudelout Arnaud , Besnard Aurélien , Bonnaire Eric , Levionnois Pauline , Muths Erin , Dufrêne Marc , Kinet Thierry 
Published: October 2018

AbstractRelocations are increasingly popular among wildlife managers despite sharp debate and low rate of relocation success in vertebrates. In this context, understanding the influence of extrinsic (e.g., relocation design, habitat characteristics) and intrinsic factors (e.g., age and sex) on demographic parameters such as survival that regulate the dynamics of relocated populations is critical to improve relocation protocols and better predict relocation success.We investigated survival in naturally established and relocated populations of yellow-bellied toads (Bombina variegata), an amphibian that was nearly extinct in Belgium by the late 1990s. We quantified survival at three ontogenetic stages (juvenile, subadult, and adult) in the relocated population, the source population, and a control population. In the relocated population, we quantified survival in captive bred individuals and their locally born descendants.We showed that survival at juvenile and subadult stages was relatively similar in all populations. In contrast, relocated adult survival was lower than adult survival in the source and control populations. Despite this, offspring of relocated animals (the next generation, regardless of life stage) survived at similar rates to offspring in the source and control populations. Our simulations revealed that the relocated population was self-sustaining under different scenarios and that the fate (e.g., stability or finite rate of increase) of the simulated populations was highly dependent on the fecundity of relocated adults and their offspring.Policy implications. Our results indicate that survival in relocated individuals is lower than in non-relocated individuals but that this cost (= reduced survival) disappears in the second generation. A finer understanding of how relocation affects demographic processes is an important step in improving relocation success of amphibians and other animals.
Widespread RNA editing dysregulation in Autism Spectrum Disorders
Authors: Tran Stephen , Jun Hyun-Ik , Bahn Jae Hoon , Azghadi Adel , Ramaswami Gokul , Van Nostrand Eric L. , Nguyen Thai B. , Hsiao Yun-Hua E. , Lee Changhoon , Pratt Gabriel A. , Yeo Gene W. , Geschwind Daniel H. , Xiao Xinshu 
Published: October 2018

AbstractAutism spectrum disorder (ASD) is a genetically complex, clinically heterogeneous neurodevelopmental disease. Recently, our understanding of the molecular abnormalities in ASD has been expanded through transcriptomic analyses of postmortem brains. However, a crucial molecular pathway involved in synaptic development, RNA editing, has not yet been studied on a genome-wide scale. Here, we profiled the global patterns of adenosine-to-inosine (A-to-I) editing in a large cohort of post-mortem ASD brains. Strikingly, we observed a global bias of hypo-editing in ASD brains, common to different brain regions and involving many genes with known neurobiological functions. Through genome-wide protein-RNA binding analyses and detailed molecular assays, we show that the Fragile X proteins, FMRP and FXR1P, interact with ADAR proteins and modulate A-to-I editing. Furthermore, we observed convergent patterns of RNA editing alterations in ASD and Fragile X syndrome, thus establishing RNA editing as a molecular link underlying these two highly related diseases. Our findings support a role for RNA editing dysregulation in ASD and highlight novel mechanisms for RNA editing regulation.
Structural model with controls of a very light airplane for numerical flutter calculations
Authors: Rogólski Robert , Olejnik Aleksander 
Published: October 2018

Purpose
The finite element model developed for a new-designed aircraft was used to solve some problems of structural dynamics. The key purpose of the task was to estimate the critical flutter velocities of the light airplane by performing numerical analysis with application of MSC Software.

Design/methodology/approach
Flutter analyses processed by Nastran require application of some complex aeroelastic model integrating two separate components – structural model and aerodynamic model. These sub-models are necessary for determining stiffness, mass and aerodynamic matrices, which are involved in the flutter equation. The aircraft structural model with its non-structural masses was developed in Patran. To determine the aerodynamic coefficient matrix, some simplified aerodynamic body-panel geometries were developed. The flutter equation was solved with the PK method.

Findings
The verified aircraft model was used to determine its normal modes in the range of 0-30 Hz. Then, some critical velocities of flutter were calculated within the range of operational velocities. As there is no certainty that the computed modes are in accordance with the natural ones, some parametric calculations are recommended. Modal frequencies depend on structural parameters that are quite difficult to identify. Adopting their values from the reasonable range, it is possible to assign the range of possible frequencies. The frequencies of rudder or elevator modes are dependent on their mass moments of inertia and rigidity of controls. The critical speeds of tail flutter were calculated for various combinations of stiffness or mass values.

Practical implications
The task described here is a preliminary calculational study of normal modes and flutter vibrations. It is necessary to prove the new airplane is free from flutter to fulfil the requirement considered in the type certification process.

Originality/value
The described approach takes into account the uncertainty of results caused by the indeterminacy of selected constructional parameters.
Composite stiffened panel sizing for conceptual tail design
Authors: Sanchez-Carmona Alejandro , Cuerno-Rejado Cristina 
Published: October 2018

Purpose
A conceptual design method for composite material stiffened panels used in aircraft tail structures and unmanned aircraft has been developed to bear compression and shear loads.

Design/methodology/approach
The method is based on classical laminated theory to fulfil the requirement of building a fast design tool, necessary for this preliminary stage. The design criterion is local and global buckling happen at the same time. In addition, it is considered that the panel does not fail due to crippling, stiffeners column buckling or other manufacturing restrictions. The final geometry is determined by minimising the area and, consequently, the weight of the panel.

Findings
The results obtained are compared with a classical method for sizing stiffened panels in aluminium. The weight prediction is validated by weight reductions in aircraft structures when comparing composite and aluminium alloys.

Research limitations/implications
The work is framed in conceptual design field, so hypotheses like material or stiffeners geometry shall be taken a priori. These hypotheses can be modified if it is necessary, but even so, the methodology continues being applicable.

Practical implications
The procedure presented in this paper allows designers to know composite structure weight of aircraft tails in commercial aviation or any lifting surface in unmanned aircraft field, even for unconventional configurations, in early stages of the design, which is an aid for them.

Originality/value
The contribution of this paper is the development of a new rapid methodology for conceptual design of composite panels and the feasible application to aircraft tails and also to unmanned aircraft.
Synthesis and optimization of modular deployable truss antenna reflector
Authors: Hu Fei , Song Yanping , Xu Yundou , Wen Huaizhou 
Published: October 2018

Purpose
This paper aims to synthesize a modular deployable truss antenna with the lower degree of freedom (DOF) and larger folding ratio. Because of the advantages of this kind of new truss antenna, the modules that make up the antenna can be deployed together by the synchronous motor drivers instead of twist springs to realize the controllable deployment.

Design/methodology/approach
The closed-loop branch equivalence method is proposed to synthesize the single DOF module and the large deployable reflector. The complex mechanism can be equivalently replaced by a simpler mechanism based on screw theory. The motion pairs are synthesized and optimized to make the curved surface achieve to the maximum folding ratio when the modular parabolic truss antenna is folded.

Findings
The results show that the 3(3RR-3RRR)-3RRR-3RRR planar module is a single DOF mechanism. Additionally, the adjacent parts of every two modules are connected with universal joints to obtain the new truss antenna when the modules are networked.

Practical implications
The configuration of this new modular deployable truss antenna can be synthesized to design the structure, and the proposed method can be applied to other space multi-loop coupling mechanism and other spacecraft.

Originality/value
This paper presents an approach to synthesizing the motion pairs, as well as the DOF analysis. The results lay a foundation for the further analysis of the deployable control and dynamics of this kind of antenna. And the new modular truss antenna has a practical application in aerospace engineering.
Principle and experimental research on vibration reduction of flexible solar array using reaction flywheel
Authors: Chen Bifa , Zhang Meiyan , Tang Guo-an 
Published: October 2018

Purpose
The rest-to-rest movements for the spacecraft, such as attitude adjustment and orbital maneuver, are likely to excite residual vibration of the flexible appendages, which may affect the attitude accuracy and even result in severe structural damage. This paper presents an approach to attenuating the vibration of flexible solar array by using reaction flywheel.

Design/methodology/approach
The reaction flywheel installed on solar array is served as an actuator to provide reaction torque to the structure according to the designed feedback control law. This torque can be considered as an artificial damping. Experiment on a scale model of the solar array is firstly performed to verify the effectiveness of this method. Numerical simulation on finite element model of a full-scale solar array is subsequently carried out to confirm the validity of this method for practical engineering application.

Findings
The vibration suppression effect on the structure by using reaction flywheel is deduced by theoretical analysis. Results from both experiment and numerical simulation reveal that the efficiency of vibration attenuation is promoted.

Research limitations/implications
Improvements on control law are left for further study. Additionally, only the first-order bending vibration of the flexible solar array is attenuated, and further study is required for other types of vibration suppression.

Practical implications
An effective method is proposed for spacecraft designers to actively suppress the vibration of the flexible solar array.

Originality/value
A novel active vibration reduction scheme is proposed by using reaction flywheel to suppress vibration of the flexible solar array. This paper fulfills a source of theoretical analysis and experimental studies for vibration reduction measure design and provides practical help for the spacecraft designers.
Consumer intention and credit card adoption in Vietnam
Authors: Nguyen Oanh Dinh Yen , Cassidy John F. 
Published: October 2018

Purpose
There is limited research on consumer intention and credit card adoption in the transitional economies of Southeast Asia. The purpose of this paper is to investigate the key elements that influence an individual’s intention of adopting credit cards in the transitional economy Vietnam.

Design/methodology/approach
A questionnaire was developed based on the technology adoption literature. After data cleaning, 595 responses were deemed valid. Factor analysis (EFA and CFA) was utilized on split samples, and a structural equation model developed to identify the influential technology adoption factors.

Findings
The analysis found strong support for the hypotheses theoretically developed. In the transitional economy of Vietnam, consumer’s intention to adopt credit cards was influenced by “Perceived usefulness (PU),” “Perceived ease of use (PEOU),” “subjective norm (SN),” “perceived self-efficacy (PSE)” and “Anxiety”. However, “perceived financial cost (PFC)” was not a significant factor.

Research limitations/implications
The use of cross-sectional data does not enable the analysis of time sequence of the determinants of consumer intention.

Practical implications
This research provides a body of knowledge on modern banking payment systems and credit card utilization factors in the transitional economy of Vietnam which has relevance for other transitional as well as developing economies of Southeast Asia, and is a good reference source for foreign investors, banks and card service companies.

Originality/value
To date, there are no studies that explore the interaction between “PU,” “PEOU,” “PFC,” “SN,” “PSE,” “Anxiety” and “Behavioral Intention” in the context of the Vietnamese credit card market, nor other transitional markets in Southeast Asia.
Mitigation of challenges in sustaining green certification in the Sri Lankan hotel sector
Authors: Bandara Chamali , Dissanayake D.M.P.P. , Karunasena Gayani , Madhusanka Nadun 
Published: October 2018

Purpose
The successful continuation of green certification in the Sri Lankan hotel sector is vital for tourism industry as well as the economy of the country as it balances the economic interests with social and environmental responsibilities. However, it has become an issue in the Sri Lankan hospitality and tourism industry to sustain green certification due to many challenges. The prevailing situation highlights the need of exploring long-term strategies to mitigate challenges in sustaining green certification which has not been researched to date. Thus, the purpose of this paper is to propose strategies to mitigate challenges in sustaining green certification in the hotel sector in Sri Lanka.

Design/methodology/approach
In total, 3 hotels were selected as cases of the study and 12 semi-structured interviews were conducted with engineers, maintenance managers and supervisors, who are responsible for sustaining green certificates at such hotels. The collected data were subjected to cross-case analysis to determine challenges in sustaining green certification. The findings were analysed with the support of the QSR.NVivo version 11.0 computer software.

Findings
Challenges were identified in detail under five main categories. They are technical, managerial, political and legal, environment and biological and social and cultural. Such challenges include design and construction defects, use of poor quality building and other materials, improper maintenance practices, incomplete and unclear construction documents, plans and specifications, resource limitations, insufficient budget allocations, government intervention, legal constraints, lack of user awareness and natural environmental conditions. Finally, strategies to mitigate such challenges are proposed based on empirical research findings.

Research limitations/implications
Only the Green Globe certified hotels in Sri Lanka were selected considering their need to renew certification annually. Further, interviewees were selected mainly focusing on the operational phase of a building. Hence, the findings were mostly limited to the perceptions and knowledge areas of selected interviewees. This can be highlighted as a primary limitation of the research, where a further study should be carried out on the perceptions of design stage professionals incorporating design stage challenges and strategies into the study.

Originality/value
The proposed strategies can be pursued by hoteliers to mitigate challenges in sustaining green certification, which will ultimately facilitate to balance economic interests with social and environmental responsibilities.
Key success factors influencing SME managers’ information behaviour on emerging ICT (EICT) adoption decision-making in UK SMEs
Authors: Eze Sunday C. , Olatunji Sulaimon , Chinedu-Eze Vera C. , Bello Adenike O. 
Published: October 2018

PurposeWhile a substantial number of studies have examined information behaviour, most centred on choice of information source, student information behaviour, information behaviour of women, environmental uncertainty and scanning behaviour of top-level hotel executives. However, little is known about how the small and medium enterprise (SME) managers scan, seek, gather, document and use information relevant for emerging information and communication technology (EICT) adoption decision-making. This paper aims to examine the key success factors influencing SME manager’s information behaviour on EICT adoption decision-making.Design/methodology/approachThis study deploys a qualitative approach to exploring 16 key success factors shaping SME managers’ information behaviour on EICT adoption decision-making. More specifically, the study adopted both unstructured and semi-structured interviews with 20 small business managers drawn purposeful from Crunch Database.FindingsThis study develops an extended technology, organisation and environment framework by incorporating the information context which helped to unravel 16 key success factors influencing small business managers’ information behaviour on EICT. From the technology context, uncertainty driven, compatibility, replacement of legacy technology, relative advantages, lack of technical know-how and perceived affordability fit for purpose influence SME managers’ information behaviour. Users’ acceptance information, efficiency driven, owner’s support shape the organisation context of perceived information need; competitor’s intelligence gathering, customer’s information gathering provider credibility and government policy influence the environmental context of perceived information need; and finally, perceived information sources credibility, herding event, testimonial and openness to other people’s ideas and experiences are shaped by the information context.Research limitations/implicationsQualitative research is normally subjective, interpretive and limited on the sample used. Because of the limited number of interviews, the generalisation of the framework and the finding is difficult. Therefore, the finding and the framework need to be established across broader population. The findings are vital considering the fact that small business managers are limited in knowledge and the study may improve the way and manner they go about seeking and gathering information relevant in adopting new ICT.Originality/valueThis research provides further insight into SME managers’ information behaviour by developing a framework and identifying main factors influencing SMEs information behaviours on EICT. Therefore, understanding such factors will enrich their knowledge on some of the factors that may shape their decisions during EICT adoption decision to make effective decision.