bluuebunny/crossref_metadata_2025_split huggingface dataset:
FACTORS INFLUENCING HEALTH CARE PROVIDER IN CODUNCTING PREECLAMPSIA SCREENING
Authors: Iflah Aninda  , Laksana Muhammad Ardian Cahya , Wittiarika Ivon Diah 
Published: November 2024

Background: Preeclampsia is responsible for maternal health globally due to its high morbidity and maternal mortality rates, especially in low-income countries such as Indonesia. Primary care providers, including general practitioners, midwives, and nurses, have a crucial role to play in the early assessment of preeclampsia screening. It was noted that factors affecting mortality were the lack of preparedness of officers in managing and responding to pregnancy emergencies, delayed recognition of worsening clinical signs of preeclampsia, as well as inadequate assessment and treatment for preeclampsia. This study aims to analyze the driving factors that influence health care provider in conducting preeclampsia screening in Gresik District. Methods: This research was an observational analytical study with a cross-sectional approach. The population in this study consisted of all doctors and midwives at the primary health facilities in the Gresik Regency area. The sample was taken from 159 respondents who were service providers in 20 primary health facilities in Gresik using simple random sampling. The variables in this study were the knowledge and attitudes of healthcare workers toward implementing preeclampsia screening. Data collection in this study used an online questionnaire conducted after issuing the Ethical Approval Letter until October 2023, which was then analyzed using a chi-square test with a significance level of 0.05. Results: Only 27% of respondents demonstrated a good level of knowledge about preeclampsia, which affected the effectiveness of preeclampsia screening (p-value 0.04). A total of 86.2% of respondents showed a high level of attitude toward preeclampsia screening. However, this study found no significant relationship between healthcare workers' attitudes and preeclampsia screening (p-value 0.171). Conclusion: There is a significant link between the knowledge of the healthcare provider and the optimization of preeclampsia screening so new methods of training are needed that are assessed as effective and accompanied by rigorous monitoring and evaluation to enhance healthcare provider knowledge, especially concerning preeclampsia screening.
Legacy of Racism and Firearm Violence During the COVID-19 Pandemic in the United States
Authors: Hans Zainab , Lee Daniel B. , Zimmerman Marc A. , Wiebe Douglas J. 
Published: November 2024

Objectives. To examine whether, through interactions with preexisting socioeconomic status vulnerabilities, the COVID-19 pandemic exacerbated exposure to firearm violence among communities with a legacy of redlining (i.e., grading the creditworthiness of neighborhoods based on their sociodemographic composition). Methods. We used an exogenous population threshold whereby the Home Owners Loan Corporation graded neighborhoods only in US cities with populations of more than 40 000 and used a difference-in-difference strategy to examine the evolution of fatal firearm incidents between 2017 and October 2022. Results. After the COVID-19 pandemic began, fatal firearm violence increased significantly in low-graded neighborhoods that the Home Owners Loan Corporation had deemed risky for mortgage lending. The effect held consistently across various model specifications. Conclusions. Social and environmental constructs can interact in a complex manner to compound disadvantage and exacerbate the consequences of negative shocks for marginalized communities. Public Health Implications. Home Owners Loan Corporation policies contributed to widening racial disparities in firearm violence, highlighting the need for reinvestment in marginalized communities to keep future shocks from exacerbating vulnerability to adverse outcomes. ( Am J Public Health. 2025;115(2):161–169. https://doi.org/10.2105/AJPH.2024.307891 )
Complete Proximal Long Head Biceps Tendon Rupture in an Elite 17-year-Old Softball Pitcher
Authors: Padua Fortunato G. , Stetler Phillip A. , Eaddy Samuel G. , Kalthoff Andrew , Miller Richard M. , Gupta Anil K. 
Published: November 2024

Case:
This case report describes the successful treatment of a year-round teenage softball pitcher who sustained a proximal biceps tendon rupture who underwent successful subpectoral tenodesis. To our knowledge, this is the only reported case of such an injury occurring in an underhand throwing teenage athlete.

Conclusion:
This case highlights an unusual instance of a sport-related injury in an adolescent softball pitcher, suggesting that the softball pitch in elite athletes may put similar stress on the shoulder to overhead throwing athletes over time and further demonstrating that patients may continue to have success at elite levels of competition after tenodesis.
Long-Term Surgical Success in Treating Vohwinkel Syndrome
Authors: Bonvillain Kirby W. , Rees Andrew B. , Drexelius Katherine D. , Serbin Ryan , Aversano Michael W. , Gaston R. Glenn 
Published: November 2024

Case:
Vohwinkel syndrome is a rare, inherited condition marked by defective keratinization. The disorder may feature digital constriction bands (pseudoainhum) which can lead to autoamputation. Surgical excision is the only treatment of pseudoainhum; however, it is fraught with recurrence. We present a 10-year-old boy with pseudoainhum of the right long and small fingers at the distal interphalangeal joints. He underwent 180-degree band excision and z-plasty.

Conclusion:
Since establishing care 8 years ago, he has undergone treatment of 5 constriction bands with only 1 recurrence. We believe this success can at least be partially attributed to the technique described by Upton.
Burden of ischemic heart disease attributable to lead exposure and projection of trends: insights from the Global Burden of Disease 2021 study
Authors: Ding Yunfa , Deng Anxia , Qi Tengfei , Yu Hao , Zhang Hongbing , Wu Liangpin 
Published: November 2024

Abstract

Aim
The purpose of this study was to quantify the global burden of ischemic heart disease attributable to lead exposure, utilizing data from the Global Burden of Disease (GBD) Study, 2021.
Methods
Data on the burden of ischemic heart disease (IHD) attributable to lead exposure were compiled globally from 1990 to 2021. These data were further stratified by dimensions including gender, age, GBD regions, and countries. Utilizing the Joinpoint regression model, we analyzed trends in the lead attributable IHD burden over time and derived the estimated annual percentage change (EAPC). For future projections, an ARIMA model was employed to forecast potential trends in the burden of IHD disease associated with lead exposure over the next decade.
Results
The study's findings reveal that in 2021, there were 590,370 deaths attributed to IHD (95% UI: -83,778 to 1,233,628) and 11,854,661 disability-adjusted life years (DALYs) (95% UI: -1,668,553 to 24,791,275) globally due to lead exposure, reflecting an increasing and then stabilizing trend from 1990 to 2021. Comparative analysis across study regions indicated a higher disease burden for IHD in regions with lower Sociodemographic Index (SDI) values, contrasting with the lower burden in regions with higher SDI values. Furthermore, IHD mortality and DALYs peak in the 70–80 age cohort, with males exhibiting higher rates compared to females. Decadal projections indicate a downward trend in IHD mortality and DALYs for regions with higher SDI, in contrast to an anticipated upward trend in regions with lower SDI.
Conclusion
The global burden of ischemic heart disease attributable to lead exposure is increasing, particularly in regions with low SDI values and within the elderly population. Considering the profound threat posed by lead exposure to the global burden of IHD, there is an imperative to consistently reinforce and execute robust prevention strategies to mitigate environmental lead exposure.
CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF-Induced Functional Orchestration of Tumor-Associated Macrophages
Authors: Deng Chu-Xia , He Lin , Peng Yuzhong , Leong Lat-lun , Zhou Jingbo , Tang Dongyang , Wang Weilu , Wu Xiaoran , Lei Josh , Ye Yongqin , Feng Yangyang , Qiao Yunfeng , Chu Xiangpeng , Mu Di , Zhao Qi , Liu Tzuming , Chen Yan , Tam Paul 
Published: November 2024

Abstract

Cyclin-dependent kinases 4 and 6 (CDK4/6) regulate cell cycle progression from the G1 to S phase. Recent findings have demonstrated that CDK4/6 inhibition (CDK4/6i) enhances antitumor immunity, as evidenced by increased tumor infiltration of CD8+ T cells, though the underlying mechanism remains unclear. Our current study reveals that CDK4/6i enhances intratumoral CD8+ T cell infiltration in breast tumors through the functional reprogramming of tumor-associated macrophages (TAMs), facilitating indirect interactions between tumor cells and CD8+ T cells. Mechanistically, CDK4/6i enhances the proliferation and activation of M1 macrophages and promote the polarization of M2 to M1 macrophages via the macrophage migration inhibitory factor (MIF)-CD44/CD74 axis between tumor cells and macrophages. CDK4/6i-trained M1 TAMs increase and activate CD8+ T cells through MHC-I antigen presentation machinery. Inhibition of MIF in tumor cells or loss of MIF reverses the immunostimulatory effects of CDK4/6i on macrophages and subsequent CD8+ T cell antitumor immunity. Therefore, CDK4/6i-trained M1 TAM supernatant therapy surmounts the immunosuppressive tumor microenvironment and invokes a tumor response to low-dose PD-1 immune checkpoint blockade therapy in breast cancers.
Nexus between inbound FDI, outbound FDI, institutions and domestic investment: Evidence from lower income countries
Authors: Husnain Muhammad Ali , Guo Ping , Ameer Waqar , Bhatti Muhammad Kamran , Zhan Qilin 
Published: November 2024

Abstract

This empirical study investigates the impact of IFDI, OFDI and IQ in promoting DCF in least developing countries. The results suggest that interactive variable (IFDIˣIQ) of IFDI and IQ significantly promote DCF in long run. Quite the reverse, interactive variable (OFDIˣIQ) of OFDI and IQ quite negligibly impact DCF in long run. This shows that compared to OFDI, IFDI can quickly reform the developing regions. Furthermore, interactive variable (OFDIˣIFDIˣIQ) of IFDI, OFDI and IQ neutrally contribute to DCF in long-run. It again reconfirms that OFDI neither play interesting role nor it is effective policy tool to promote DCF in long run for lower income countries.
JEL Classification: C23; F20; F21; F23
Phase separation of AKAP95 regulates oncogenic MLL-fusion driven transcription and its modulation for cancer therapy
Authors: Li Wei 
Published: November 2024

Abstract

RNA binding proteins (RBPs) have been reported to own genome-wide chromatin binding sites, and are supposed to regulate transcription directly. However, the molecular detail about RBPs regulating transcription is still unclear. Here, we showed the RBP AKAP95 engaged in transcription regulation through tethering itself to nascent RNA on chromatin. Further, phase separation enabled AKAP95 having large spectrum coverage on transcription start sites and meanwhile recruiting RNA polymerase II CTD to activate transcription. This transcription co-activation mechanism was hijacked in MLL rearranged (MLLr) leukemia. AKAP95 was enclosed in the same condensates with MLL1 translocated fragment. It was required for MLLr leukemogenesis, but not for normal and regenerative hematopoiesis, rendering AKAP95 an ideal target for leukemia therapeutics. As an endeavor for modifying condensates, we designed a peptide bridging AKAP95 with protein quality surveillance component HSP70. This peptide successfully impaired AKAP95 phase separation, transcription activation and cancer cell growth, attesting the concept that oncogenic condensates is druggable.
Performance Enhancement and Energy Savings in Domestic Refrigeration Systems Using Al2O3/ZrO2 Nanoparticle with PAG Oil as a Hybrid Nano lubricant
Authors: Barza Tesfaye , Tadele Akalework 
Published: November 2024

Abstract

This study focuses on performance enhancement and energy savings in domestic refrigeration systems using Al2O3/ZrO2 nanoparticles with PAG oil as a hybrid nanolubricant. Performance can be improved by lowering compressor power or increasing the evaporator's rate of heat absorption. Nanolubricants are known to enhance heat transfer, reduce compressor workload, and increase overall efficiency. In this study, R-600a refrigerant in a refrigeration system was evaluated using Al2O3/ZrO2 hybrid nanolubricant at (0.2, 0.4, and 0.6 g/L) with 70 g of R-600a refrigerant. Key metrics are compressor power consumption, refrigeration effect, and Coefficient of Performance (COP). Compared to an R-600a system without nano lubricant, the hybrid nanoparticles increased cooling capacity by 5.94%, reduced compressor power consumption by 28.35%, and raised COP by 46.2%, from 3 to 4.05. The R-600a refrigerant is environmentally friendly and ozone-safe. Polyalkylene glycol (PAG) oil was used as the lubricant, with nanoparticles dispersed via ultrasonication and magnetic stirring. Performance tests demonstrated significant improvements in COP, refrigeration effect, and power consumption with the hybrid nano lubricant. The results revealed that the Al2O3/ZrO2 hybrid nanolubricant significantly increased the system's cooling capacity and thermal efficiency.
Multilayered modular microfluidic platform for 3D vascularized organ-on-a-chip application
Authors: Wang Xiaolin , Zhou Chenyang , Li Zhangjie , Xu Jiaqi , Yu Dingyuan , Xuan Lian 
Published: November 2024

Abstract

The vascular network is integral to the developmental and metabolic processes of various tissues, functioning as a systemic circulatory system that also interconnects organs throughout the body. In this study, we present a multilayered modular microfluidic organ-on-a-chip platform designed for the reproduction of various 3D vascularized microtissue models for biological applications. This platform employs a porous membrane as the physical barrier and utilizes capillary action for hydrogel self-filling. Its high flow resistance mitigates the risk of gel bursting into the medium channels, while also facilitating substance delivery to generate a wide range of interstitial flow and biochemical factor concentration gradients. We demonstrated that this platform can be utilized to accurately replicate 3D microenvironment for vasculogenesis, angiogenesis, and vascularized tumor. Furthermore, the critical role of multiple microenvironmental regulation in the vascular formation was investigated on chip. We also reproduced the process of tumor angiogenesis, including primary solid tumor features and the inhibitory effects of anti-tumor drug on tumor growth and tumor vasculature both before or after angiogenesis. Consequently, our multilayered microfluidic platform is a valuable modular platform for studying multiple vascular mechanisms and constructing specific microtissues that closely mimic to physiological conditions in vivo, offering new strategies for cancer research. Additionally, the multilayered configuration enhances design flexibility and scalability, which provides the potential for a multi-organ interconnected platform for high-throughput drug screening.
Curcumol Inhibits Colorectal Cancer Progression by Regulating Glycolysis and Metastasis through VHL/ HIF-1α Pathway Suppression
Authors: Wang Gang , Yue Zengyaran , Bian Yong , Sun Ruiqian , Zhu Lifeng , Tang Decai , Yin Gang 
Published: November 2024

Abstract

Background
Colorectal cancer (CRC) progression is strongly influenced by metabolic reprogramming, particularly under hypoxic conditions, where hypoxia-inducible factor 1 alpha (HIF-1α) acts as a critical driver. HIF-1α upregulates glycolytic enzymes, promoting both tumor cell survival and invasive potential. Excessive lactate production, resulting from heightened glycolysis, not only facilitates tumor adaptation to hypoxia but also acidifies the tumor microenvironment, leading to immune suppression. Targeting HIF-1α and lactate metabolism has therefore emerged as a promising therapeutic approach in CRC. However, most existing therapies focus on inhibiting HIF-1α expression without addressing its degradation pathways. Curcumol, a sesquiterpenoid derived from Curcuma species, exhibits a unique mechanism by promoting HIF-1α degradation via the von Hippel-Lindau (VHL) pathway. This dual action of curcumol—restoring VHL activity while suppressing HIF-1α stability—offers a novel approach for interfering with CRC metabolic reprogramming.
Methods
This study employed two approaches to validate the therapeutic effect of curcumol, including an in vivo Balb/c mouse orthotopic tumor transplantation model and an in vitro hypoxia model of colorectal cancer cell lines. Hematoxylin and eosin (HE) staining was performed to examine pathological changes in tumor tissues, and immunohistochemistry was used to verify the positive expression rate of HIF-1α in tumor tissues. The XF 96 Seahorse metabolic analyzer was utilized to measure the glycolytic metabolism pathway in colorectal cancer cell lines. In addition, Western blotting, immunofluorescence, and q-PCR were applied to assess the expression levels of HIF-1α and glycolysis-related markers in tumor tissues and colorectal cancer cells. Glycolytic enzyme activity assay kits were also used to detect the activity of key glycolytic enzymes, while co-immunoprecipitation (Co-IP) was conducted to evaluate the interaction between HIF-1α and VHL. Furthermore, a VHL gene knockout mouse model was established to investigate curcumol's effect on the VHL-HIF-1α pathway.
Results
Curcumol significantly restored VHL expression, reduced HIF-1α stability, and downregulated glycolytic genes (HK2, LDHA), leading to reduction in lactate production. Moreover, curcumol improved the acidic conditions of the tumor microenvironment by lowering lactate levels, and suppressing CRC cell proliferation and invasion.
Conclusion
Curcumol inhibits HIF-1α-mediated metabolic reprogramming, significantly improving the CRC tumor microenvironment. Future studies should validate curcumol’s efficacy in animal models and explore its potential for combination with metabolic inhibitors or chemotherapy, offering a promising therapeutic strategy for advanced CRC.
First report of leaf spot caused by Colletotrichum siamense on Ocimum tenuiflorum in India.
Authors: Mukherjee Soumik , MUKHOPADHYAY ANKUR , Singh Siddharth , Oraon Susmita , Mondal Goutam 
Published: November 2024

Abstract

A leaf spot disease of Indian basil has been observed in Kalyani, West Bengal during the month of September 2022–2023. The disease symptoms appeared as light to dark brown circular spots with irregular margins which rarely coalesced and covered the entire leaf surface. The pathogen was identified through morphological and molecular analyses as an ascomycetes fungus Colletotrichum siamense. The leaf spot causes serious damage to leaf yield with severity estimated up to 30–50%. This is the first record of C. siamense causing leaf spot on Indian basil in the country.
Follow-up study on factors influencing the persistence of asthma in discharged children
Authors: Zou Huimin , Han Peng , Yin Ju , Shen Kunling 
Published: November 2024

Abstract

Background: The process of asthma, after its onset, is featured by periods of persistence, relapse and remission. This follow-up study explored factors affecting the persistence of asthma in children aged 0-18 years at Beijing Children's Hospital.
Methods:Children hospitalized in Beijing Children's Hospital from 2019 to 2021 due to acute asthma attacks were selected as the study objects. A questionnaire was used to collect asthma management and attacks after discharge. This study defined asthma persistence as having ≥1 asthma attacks within nearly one year, in contrast，asthma remission is being free of asthma attack for one consecutive year. Univariate and multivariate logistic regression analyses were used to find factors which affect the persistence of asthma.
Results:152 children participated in this study, including 103 males (67.8%) and 49 females (32.2%), with a male-to-female ratio of 2.1:1. Among these patients, the frequency of asthma attacks after discharge varied with different follow-up duration. 31.6% of children with asthma had regular follow-up visits, 36.8% had regular use of inhaled corticosteroids for 3 months or more, and 42.8% used ICS only for asthma symptoms. There were 75 children with remission of asthma and 77 children with persistence. There were no significant differences in sex, age, environmental exposures, or medicine use between the two groups. Multivariate logistic regression analysis showed that the independent risk factors for asthma persistence were: combination of allergic rhinitis(3.726,95%CI 1.576-8.881; p=0.003), respiratory infection as asthma attack trigger(OR4.197,95%CI 1.000-17.614; p=0.050), ≥3 acute asthma attacks(OR9.653, 95%CI 4.036-23.088; p<0.001), and unplanned healthcare attendances related to asthma attacks (OR9.666, 95%CI 2.877-32.476;p<0.001).
Conclusions:The children with asthma still had recurrent asthma attacks after discharge, poor medication compliance, no regular follow-up, and family management was not optimistic. Allergic rhinitis, respiratory tract infection as asthma attack trigger, ≥3 acute asthma attacks, and unplanned healthcare attendances related to asthma attack can predict the persistence of asthma.
Trial registration: The study was registered at https://clinicaltrials.gov/ with the number: NCT05800379 on 05/04/2023.
Quantum-Inspired Federated Learning for Privacy-Preserving and Communication- Efficient Healthcare IoT Systems
Authors: T Subaranjani , A Stephan Antony Raj 
Published: November 2024

Abstract

With the increasing deployment of healthcare IoT (HIoT) systems, it is crucial to solve the data privacy problem and avoid information leakage while ensuring communications efficiency. Traditional FL models are usually decentralized, but they often face high communication overhead and severe privacy risks. In this paper, we firstly propose a novel quantum-inspired FL model to mitigate the information leakage, reduce the energy consumption and communication cost in HIoT systems. Besides, we adopt quantum-inspired differential privacy mechanisms to prevent information leakage and quantum optimization techniques to minimize communication rounds and accelerate the convergence of FL training. To verify the performances of the proposed quantum-inspired FL model in a federated healthcare IoT environment, we conduct extensive experiments and the results show the proposed model can reduce the communication overhead by 22.1%, lower the energy consumption by 16.8%, and guarantee accurate prediction with high accuracy above 91.9% for both training and test groups, which outperforms the traditional methods. This estimated the gap between FL and QL and launched a promising vision of scalable and energy-efficient model for privacy-sensitive applications in HIoT systems.