bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nasty surprise: cardiogenic shock induced by extensive dissection of the left internal mammary artery graft occurring 3 months after coronary angiography—a case report
Authors: Ebelt Henning , Röhl Peter , Schwenzky Andreas , Hoyme Matthias , Wiora Matthias 
Published: September 2019

Abstract

Background
Acute dissection of the left internal mammary artery (LIMA) graft in patients with previous cardiac bypass surgery is a rare but potentially life-threatening condition.

Case summary
A 58-year-old man with history of coronary artery disease and bypass surgery 15 years ago presented with acute coronary syndrome (non-ST-elevation myocardial infarction, NSTEMI). Angiography showed severe three-vessel disease with occlusion of a saphenous vein graft (SVG) to the first diagonal branch but patents grafts to left artery descendent (LIMA) and SVG to the right coronary artery. No coronary intervention was performed and the patient was treated medically (aspirin and ticagrelor) and discharged home after 6 days. Three months later, the patient again was admitted to the hospital with acute coronary syndrome (NSTEMI) and developing cardiogenic shock. Angiography now showed an extensive flow limiting dissection of his LIMA graft with the dissection starting at the ostium of the LIMA. After implantation of an Impella 2.5, percutaneous coronary intervention (PCI) of the graft was performed under guidance by optical coherence tomography (OCT) leading to implantation of a drug-eluting stent into the ostium of the LIMA and repeated balloon dilatations of the medial and distal parts of the graft. Antegrade flow was established and the patient’s condition improved so that the Impella was removed in the cath lab. After an uneventful course, the patient was discharged home after 6 days. Elective repeat angiography after 8 weeks showed an excellent functional result without persisting signs of LIMA dissection or stenosis.

Discussion
Acute dissection of a LIMA graft is a rare event that may lead to a life-threatening condition. According to the literature, LIMA dissection happens during coronary interventions in approximately half of the cases but it also may evolve spontaneously. However, as seen from our case, there might be a substantial delay between LIMA angiography and the clinical onset of dissection. In the vast majority of cases, dissection of LIMA can be treated by PCI. The use of Impella as reported for the first time in this case may improve the safety of the procedure. In accordance to PCI of the native coronary arteries, it seems possible to leave non-flow limiting dissections in cases of extensive disease in order to avoid the late complications of complete stenting of the graft.
A new model of patient-centred care for general practitioners: results of an integrative review
Authors: Brickley Bryce , Sladdin Ishtar , Williams Lauren T , Morgan Mark , Ross Alyson , Trigger Kellie , Ball Lauren 
Published: September 2019

Abstract

Background
GPs providing patient-centred care (PCC) is embedded in international health care policies due to its positive impact on patients and potential to lower health care costs. However, what is currently known about GP-delivered PCC is unknown.

Objective
To synthesize literature investigating GP-delivered PCC and address ‘what is currently known about GP-delivered PCC?’

Method
A systematic literature search was conducted between June and July 2018. Eligible articles were empirical, full-text studies published in English between January 2003 and July 2018, related to at least three of the four dimensions of PCC described by Hudon et al. (2011), and related to preventative, acute, and/or chronic care by GPs. Following screening, full-text articles were independently assessed for inclusion by two investigators. Data were extracted and quality assessed by two researchers. Findings on PCC were analysed thematically (meta-synthesis).

Results
Thirty medium- to high-quality studies met the inclusions criteria. Included studies utilized varied designs, with the most frequent being quantitative, cross-sectional. A theoretical model of PCC was synthesized from included studies and contained four major components: (i) understanding the whole person, (ii) finding common ground, (iii) experiencing time and (iv) aiming for positive outcomes. Harms of PCC were rarely reported.

Conclusions
Four overarching theoretical components of PCC relate to elements of the consultation and experience of time. These components can be used to inform the development of toolkits to support GPs and general practice organizations in pursuit of PCC as well as tools to measure patient-centredness.
Sex Differences in Escalated Methamphetamine Self-Administration and Altered Gene Expression Associated With Incubation of Methamphetamine Seeking
Authors: Daiwile Atul P , Jayanthi Subramaniam , Ladenheim Bruce , McCoy Michael T , Brannock Christie , Schroeder Jennifer , Cadet Jean Lud 
Published: September 2019

AbstractBackgroundMethamphetamine (METH) use disorder is prevalent worldwide. There are reports of sex differences in quantities of drug used and relapses to drug use among individuals with METH use disorder. However, the molecular neurobiology of these potential sex differences remains unknown.MethodsWe trained rats to self-administer METH (0. 1 mg/kg/infusion, i.v.) on an fixed-ratio-1 schedule for 20 days using two 3-hour daily METH sessions separated by 30-minute breaks. At the end of self-administration training, rats underwent tests of cue-induced METH seeking on withdrawal days 3 and 30. Twenty-four hours later, nucleus accumbens was dissected and then used to measure neuropeptide mRNA levels.ResultsBehavioral results show that male rats increased the number of METH infusions earlier during self-administration training and took more METH than females. Both male and female rats could be further divided into 2 phenotypes labeled high and low takers based on the degree of escalation that they exhibited during the course of the METH self-administration experiment. Both males and females exhibited incubation of METH seeking after 30 days of forced withdrawal. Females had higher basal mRNA levels of dynorphin and hypocretin/orexin receptors than males, whereas males expressed higher vasopressin mRNA levels than females under saline and METH conditions. Unexpectedly, only males showed increased expression of nucleus accumbens dynorphin after METH self-administration. Moreover, there were significant correlations between nucleus accumbens Hcrtr1, Hcrtr2, Crhr2, and Avpr1b mRNA levels and cue-induced METH seeking only in female rats.ConclusionOur results identify some behavioral and molecular differences between male and female rats that had self-administered METH. Sexual dimorphism in responses to METH exposure should be considered when developing potential therapeutic agents against METH use disorder.
Counter-Selection of Antimalarial Resistance Polymorphisms by Intermittent Preventive Treatment in Pregnancy
Authors: Huijben Silvie , Macete Eusebio , Mombo-Ngoma Ghyslain , Ramharter Michael , Kariuki Simon , Desai Meghna , Shi Ya Ping , Mwangoka Grace , Massougbodji Achille , Cot Michel , Ndam Nicaise Tuikue , Uberegui Estefania , Gupta Himanshu , Cisteró Pau , Aponte John J , González Raquel , Menéndez Clara , Mayor Alfredo 
Published: September 2019

Abstract

Background
Innovative approaches are needed to limit antimalarial resistance evolution. Understanding the role of intermittent preventive treatment in pregnancy (IPTp) on the selection for resistance and the impact such selection has on pregnancy outcomes can guide future interventions.

Methods
Plasmodium falciparum isolates (n = 914) from 2 randomized clinical trials were screened for pfmdr1 copy number variation and pfcrt, pfmdr1, pfdhfr, and pfdhps resistance markers. The trials were conducted between 2010 and 2013 in Benin, Gabon, Kenya, and Mozambique to establish the efficacy of IPTp-mefloquine (MQ) compared with IPTp-sulphadoxine-pyrimethamine (SP) in human immunodeficiency virus (HIV)-uninfected and to IPTp-placebo in HIV-infected women.

Results
In HIV-uninfected women, the prevalence of pfcrt mutants, pfdhfr/pfdhps quintuple mutants, and pfmdr1 copy number was similar between women receiving IPT-SP and IPTp-MQ. However, prevalence of pfmdr1 polymorphism 86Y was lower in the IPTp-MQ group than in the IPTp-SP group, and within the IPTp-MQ group it was lower at delivery compared with recruitment. No effect of IPTp-MQ on resistance markers was observed among HIV-infected women. The carriage of resistance markers was not associated with pregnancy outcomes.

Conclusions
Selection of wild-type pfmdr1 polymorphism N86 by IPTp-MQ highlights the strong selective pressure IPTp can exert and the opportunity for using negative cross-resistance in drug choice for clinical treatment and IPTp.
Identification of Naturally Processed Mumps Virus Epitopes by Mass Spectrometry: Confirmation of Multiple CD8+ T-Cell Responses in Mumps Patients
Authors: de Wit Jelle , Emmelot Maarten E , Meiring Hugo , van Gaans-van den Brink Jacqueline A M , van Els Cécile A C M , Kaaijk Patricia 
Published: September 2019

Abstract

Background
The re-emergence of mumps among vaccinated young adults has become a global issue. Besides waning of antibody responses, suboptimal induction of T-cell responses may reduce protection. In a recent study, we observed a dominant polyfunctional CD8+ T-cell response after natural mumps virus (MuV) infection that was not present after vaccination. Unraveling the MuV epitope repertoire can provide insight in the specificity, functionality, and breadth of the T-cell response against MuV.

Methods
Peptides were eluted from human leukocyte antigen (HLA) class I molecules of MuV-infected cells and characterized by advanced mass spectrometry. Selected identified MuV peptides were tested for in vitro and ex vivo immunogenicity.

Results
In this study, we identified a broad landscape of 83 CD8+ T-cell epitopes of MuV, 41 of which were confirmed based on synthetic peptide standards. For 6 epitopes, we showed induction of an HLA-A*02-restriced CD8+ T-cell response. Moreover, robust T-cell responses against 5 selected MuV epitopes could be detected in all tested mumps patients using peptide/HLA-A*02:01 dextramers.

Conclusions
The identified CD8+ T-cell epitopes will help to further characterize MuV-specific T-cell immunity after natural MuV infection or vaccination. These MuV epitopes may provide clues for a better understanding of, and possibly for preventing, mumps vaccine failure.
We identified for the first time 41 mumps virus (MuV)-specific HLA-A*02 epitopes. For 6 epitopes, CD8+ T-cell responses were confirmed in T cells derived from several mumps cases, and MuV-specific CD8+ T cells could be identified by peptide/dextramer staining.
“Essential Things Such as Typewriters”: Development Discourse, Trade Union Expertise, and the Dialogues of Decolonization between the Caribbean and West Africa
Authors: James Leslie 
Published: September 2019

Abstract
This article examines how the liberatory ideals of transnational projects could become codified in particular processes of thought, deed, and expression. During his term of service in Nigeria between 1960 and 1962 the Trinidadian union leader McDonald Moses mobilized a number of phenomena central to the transformative projects of the mid-twentieth century: the paramountcy of psychology to “true” transformation and change; the embrace of programmatic action; and the belief that both psychological transformation and programmatic action could be articulated through new and enlightened forms of expression. While histories that embrace a “cultural turn” tend to look for this expression in creative forms and artistic production, this article looks to daily administrivia as part of an explicitly political project that aimed to improve the lives of workers by changing their modes of organizing and, consequently, the culture of politics and labor.
Decommissioning in Brazil: legal aspects of a technical analysis
Authors: Kowarski Clarissa Brandão , de Souza Marcelo Igor Lourenço , de Souza Renato Barcellos 
Published: September 2019

Abstract
This paper presents legal contributions to the technical analysis of the decommissioning stages of the oil industry. We seek to contribute to decision making based on multicriteria analysis about the options for uninstalling specific equipment in the production chain: subsea equipment. The objective is to demonstrate that there is legal predictability supported by the technical aspect for the options that are possible in each case. The methodology used was the literary revision combined with a national and international legislative analysis that allowed the presentation of the final conclusion. The comparison between the international norms, as well as the Brazilian legislation, in particular, the national solid waste policy demonstrated the legality of the application of a multicriteria analysis to base the decisions by the companies, as well as the inspection agencies.
The hidden satellites of massive galaxies and quasars at high redshift
Authors: Costa Tiago , Rosdahl Joakim , Kimm Taysun 
Published: September 2019

ABSTRACT
Using cosmological, radiation-hydrodynamic simulations targeting a rare ${\approx}2 \times 10^{12} \, \rm {\rm M}_{\odot }$ halo at $z = 6$, we show that the number counts and internal properties of satellite galaxies within the massive halo are sensitively regulated by a combination of local stellar radiative feedback and strong tidal forces. Radiative feedback operates before the first supernova explosions erupt and results in less tightly bound galaxies. Satellites are therefore more vulnerable to tidal stripping when they accrete on to the main progenitor and are tidally disrupted on a significantly shorter time-scale. Consequently, the number of satellites with $M_{\rm \star } \gt 10^{7} \, \rm {\rm M}_{\odot }$ within the parent system’s virial radius drops by up to $60 \, {\rm per\, cent}$ with respect to an identical simulation performed without stellar radiative feedback. Radiative feedback also impacts the central galaxy, whose effective radius increases by a factor ≲3 due to the presence of a more extended and diffuse stellar component. We suggest that the number of satellites in the vicinity of massive high-redshift galaxies is an indication of the strength of stellar radiative feedback and can be anomalously low in the extreme cosmic environments of high-redshift quasars.
AGN jet feedback on a moving mesh: lobe energetics and X-ray properties in a realistic cluster environment
Authors: Bourne Martin A , Sijacki Debora , Puchwein Ewald 
Published: September 2019

ABSTRACT
Jet feedback from active galactic nuclei (AGN) harboured by brightest cluster galaxies is expected to play a fundamental role in regulating cooling in the intracluster medium (ICM). While observations and theory suggest energy within jet lobes balances ICM radiative losses, the modus operandi of energy communication with the ICM remains unclear. We present simulations of very high resolution AGN-driven jets launching in a live, cosmological galaxy cluster, within the moving mesh code arepo. As the jet propagates through the ICM the majority of its energy, which is initially in the kinetic form, thermalizes quickly through internal shocks and inflates lobes of very hot gas. The jets effectively heat the cluster core, with PdV work and weather-aided mixing being the main channels of energy transfer from the lobes to the ICM, while strong shocks and turbulence are subdominant. We additionally present detailed mock X-ray maps at different stages of evolution, revealing clear cavities surrounded by X-ray bright rims, with lobes being detectable for up to ∼108 yr even when magnetic draping is ineffective. We find bulk motions in the cluster can significantly affect lobe propagation, offsetting them from the jet direction and imparting bulk velocities that can dominate over the buoyantly rising motion.
Advances in Intraoperative Optics: A Brief Review of Current Exoscope Platforms
Authors: Langer David J , White Timothy G , Schulder Michael , Boockvar John A , Labib Mohamed , Lawton Michael T 
Published: September 2019

Abstract

BACKGROUND
The advent of the operating microscope (OM) revolutionized the field of neurosurgery. It allowed surgeons to operate on and effectively treat diseases previously inaccessible with conventional eyesight because of magnification and illumination. Improvements in the essential methods of visualization and the quality of the optics have plateaued. Another main limitation of the OM remains its ergonomics because of the need of the surgeon and assistant to directly interface with the OM objective. Recently, exoscopes have been introduced to overcome some shortcomings of the conventional OM.

OBJECTIVE
To subjectively review the individual authors experience with the current exoscope platforms in an attempt to provide a resource to the neurosurgeon when considering imaging options.

METHODS
Experts with previous use of each individual platform were contacted and asked to contribute their experiences.

RESULTS
In total, 4 systems are discussed. They include the VITOM (Karl Storz, Tuttlingen, Germany), the Olympus ORBEYE (Olympus, Tokyo, Japan), the Synaptive Modus V (Synaptive Medical, Toronto, Canada), and the Zeiss KINEVO (Carl Zeiss AG, Oberkochen, Germany).

CONCLUSION
The advent of exoscopes has the potential to begin to allow surgeons to move beyond solely the microscope for intraoperative visualization while improving upon its ergonomic disadvantages.
An Apple B-Box Protein MdBBX37 Modulates Anthocyanin Biosynthesis and Hypocotyl Elongation Synergistically with MdMYBs and MdHY5
Authors: An Jian-Ping , Wang Xiao-Fei , Espley Richard V , Lin-Wang Kui , Bi Si-Qi , You Chun-Xiang , Hao Yu-Jin 
Published: September 2019

AbstractAs an important environment factor, light affects plant growth and development throughout life. B-BOX (BBX) proteins play key roles in the regulation of light signaling. Although the multiple roles of BBX proteins have been extensively studied in Arabidopsis, the research in apple is much less extensive. In this study, we systematically characterized the negative role of an apple BBX protein MdBBX37 in light signaling, including inhibiting anthocyanin biosynthesis and promoting hypocotyl elongation. We found that MdBBX37 interacted with MdMYB1 and MdMYB9, two key positive regulators of anthocyanin biosynthesis, and inhibited the binding of those two proteins to their target genes and, therefore, negatively regulated anthocyanin biosynthesis. In addition, MdBBX37 directly bound to the promoter of MdHY5, a positive regulator of light signaling, and suppressed its expression, and thus relieved MdHY5-mediated hypocotyl inhibition. Taken together, our investigations suggest that MdBBX37 is a negative regulator of light signaling in apple. Our study will provide reference for further study on the functions of BBX proteins in apple.
Interrogating Genomic-Scale Data for Squamata (Lizards, Snakes, and Amphisbaenians) Shows no Support for Key Traditional Morphological Relationships
Authors: Burbrink Frank T , Grazziotin Felipe G , Pyron R Alexander , Cundall David , Donnellan Steve , Irish Frances , Keogh J Scott , Kraus Fred , Murphy Robert W , Noonan Brice , Raxworthy Christopher J , Ruane Sara , Lemmon Alan R , Lemmon Emily Moriarty , Zaher Hussam 
Published: September 2019

AbstractGenomics is narrowing uncertainty in the phylogenetic structure for many amniote groups. For one of the most diverse and species-rich groups, the squamate reptiles (lizards, snakes, and amphisbaenians), an inverse correlation between the number of taxa and loci sampled still persists across all publications using DNA sequence data and reaching a consensus on the relationships among them has been highly problematic. In this study, we use high-throughput sequence data from 289 samples covering 75 families of squamates to address phylogenetic affinities, estimate divergence times, and characterize residual topological uncertainty in the presence of genome-scale data. Importantly, we address genomic support for the traditional taxonomic groupings Scleroglossa and Macrostomata using novel machine-learning techniques. We interrogate genes using various metrics inherent to these loci, including parsimony-informative sites (PIS), phylogenetic informativeness, length, gaps, number of substitutions, and site concordance to understand why certain loci fail to find previously well-supported molecular clades and how they fail to support species-tree estimates. We show that both incomplete lineage sorting and poor gene-tree estimation (due to a few undesirable gene properties, such as an insufficient number of PIS), may account for most gene and species-tree discordance. We find overwhelming signal for Toxicofera, and also show that none of the loci included in this study supports Scleroglossa or Macrostomata. We comment on the origins and diversification of Squamata throughout the Mesozoic and underscore remaining uncertainties that persist in both deeper parts of the tree (e.g., relationships between Dibamia, Gekkota, and remaining squamates; among the three toxicoferan clades Iguania, Serpentes, and Anguiformes) and within specific clades (e.g., affinities among gekkotan, pleurodont iguanians, and colubroid families).
How Left Ventricular Size Affects Severity of Disease and Long-term Prognosis in Patients with Severe Systolic Dysfunction?
Authors: Amin Ahmad , Chitsazan Mitra , Ofoghi Mahdis , Taghavi Sepideh , Naderi Nasim , Chitsazan Mandana 
Published: September 2019

Background:
We compared the severity of disease, heart failure (HF) rehospitalization and trend of changes over a 12-month follow-up in clinical and biochemical measurements between dilated cardiomyopathy (DCM) patients and those with left ventricular systolic dysfunction with normal LV size (NLVS). The existing definition of DCM failed to justify our observations in some clinical circumstances resulting in diagnostic and prognostic challenges.

Methods:
A total of 77 patients [52 (67.5%) male] including 40 patients in the NLVS group and 37 patients in the DCM group were enrolled and followed up for a median of 12 months [interquartile range, 11–14 months].

Results:
Mean left ventricular ejection fraction was statistically comparable between NLVS and DCM patients (22 ± 8% vs. 19 ± 6%, P = 0.08]. The New York Heart Association class was statistically comparable in both groups (P = 0.23). Laboratory measurements including hemoglobin, sodium, creatinine, uric acid, and NT-proBNP level were also statistically similar in both groups (all P > 0.05). During follow-up, HF rehospitalization occurred in 16 (76%) patients in NLVS and 5 (24%) patients in DCM groups (P = 0.009). Except for left ventricular ejection fraction which improved in both NLVS and DCM groups, no significant changes were observed in clinical (New York Heart Association class) and laboratory measurements during follow-up in both NLVS and DCM groups.

Conclusions:
Our study showed that NLVS defines a group of systolic HF patients which not only did not have less severe disease than those with enlarged left ventricules (i.e., DCM), also had more HF rehospitalization. These NLVS patients also had steady clinical, laboratory, and echocardiographic profile during follow-up.