bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐SMC condensin I complex subunit H enhances proliferation, migration, and invasion of hepatocellular carcinoma
Authors: Sun Chengjun , Huang Shanzhou , Wang Hanyu , Xie Rongxing , Zhang Lishan , Zhou Qi , He Xiaoshun , Ju Weiqiang 
Published: September 2019

AbstractNon‐SMC condensing I complex subunit H (NCAPH) is a member of the Barr protein family and part of the condensin I complex. The upregulation of NCAPH is associated with poor prognosis in patients with colon cancer. However, the relationship between NCAPH and hepatocellular carcinoma (HCC) remains unclear. This study aimed to explore NCAPH expression in HCC tissues and to investigate NCAPH functions in HCC cells. In this study, we found that high expression of NCAPH in HCC indicated worse prognosis via bioinformatics analysis. Consistently, quantitative real‐time polymerase chain reaction assays in 20 pairs of HCC specimens and the immunohistochemical analysis of 100 HCC tissues showed the upregulation of NCAPH. We established stable NCAPH‐overexpressing and NCAPH knockdown cell lines. Cell Counting Kit‐8 assays and colony formation assay were performed to analyze cell proliferation. Migration and invasion were analyzed by Transwell assays. Subcutaneous xenograft models were used to explore the role of NCAPH in tumor formation in vivo. Our results showed that NCAPH promoted tumor proliferation, migration, and invasion in vitro and in vivo. In conclusion, our findings indicate that NCAPH could serve as a novel prognostic biomarker and a potential therapeutic target for patients with HCC.
Hitting the gas or the brake? Recessions and firms' knowledge investments
Authors: Knudsen Eirik Sjåholm , Lien Lasse B. 
Published: September 2019

PurposeWe examine how firms alter their investment behavior in response to changes in demand and access to credit during recessions. We compare and contrast investment changes in physical assets, R&D, and human capital.FindingsWe find that firms tend to shield R&D investments from transitory fluctuations in demand and that R&D investments are more sensitive to credit changes than usually assumed. For human capital, we find a cubic relationship between investments and demand changes.ConclusionImportant variation and trade‐offs remain hidden if investment is treated as a single category or if the distinction between demand and credit impulses is not made.
How transformational leadership positively impacts organizational citizenship behavior in successful Chinese social work service organizations
Authors: Zhang Huan , Liu Ziyu , Wang Yean 
Published: September 2019

AbstractSocial work service organizations (SWSOs) have developed quickly, and there were nearly 8,000 of such organizations throughout China in the end of 2017. However, this rapid growth has brought both great opportunities and challenges. Globally, leadership has received increasing attention in the social work profession in the 21st century. Among different types of leadership, transformational leadership has been identified as a key issue in bringing more innovation and motivating employees' organizational citizenship behavior to overcome such challenges. Therefore, this study aimed to focus on social workers from the 170 applicants of the “Top 100 Social Work Service Organizations of 2017” which could be seen as the more successful SWSOs in China to examine how transformational leadership impacts organizational citizenship behavior by considering two mechanisms, workplace social capital and professional autonomy, in different areas throughout China. A two‐step process analysis was employed. First, a structural equation model was theoretically built, and it examined the direct and indirect relationships among all four latent variables, considering two mediation effects. Second, multiple group (high social work developed area group versus low social work developed area group) analyses tested the moderation effect. This study confirmed the key role of transformational leadership in the success of SWSOs and found workplace social capital as a full mediator and professional autonomy as a partial mediator in the relationship between transformational leadership and organizational citizenship behavior. These findings may shed light on the further development of SWSOs from the perspective of enhancing social workers' organizational citizenship behavior.
Donors in transition and the future of development cooperation: What do the data from Brazil, India, China, and South Africa reveal?
Authors: Gulrajani Nilima , Faure Raphaëlle 
Published: September 2019

SummaryHow are Development Assistance Committee (DAC) donors evolving their financial flows and aid modalities in response to the growing influence and economic power of Southern BRICS? After presenting the shifting landscape of international development cooperation, we explore five hypotheses about the changing nature of DAC aid allocation patterns and modalities in BRICS countries. In our conclusion, we reflect on the evolution of DAC engagement in Brazil, China, India, and South Africa (BASIC countries) and what it might mean for all official donors. Our assessment is that the changing geopolitical environment for development cooperation is once again privileging economic diplomacy concerns within DAC donors, propelling specific kinds of decisions about the choice of instruments, sectors, and modalities in BASIC countries. It would appear that the administrative practice of foreign aid is increasingly derived from changes within the institutional environment for international development.
Latest developments in post‐mortem foetal imaging
Authors: Shelmerdine Susan C. , Hutchinson John C. , Arthurs Owen J. , Sebire Neil J. 
Published: September 2019

AbstractA sustained decline in parental consent rates for perinatal autopsies has driven the development of less‐invasive methods for death investigation. A wide variety of imaging modalities have been developed for this purpose and include post‐mortem whole body magnetic resonance imaging (MRI), ultrasound, computed tomography (CT) and micro‐focus CT techniques. These are also vital for “minimally invasive” methods, which include potential for tissue sampling, such as image guidance for targeted biopsies and laparoscopic‐assisted techniques. In this article, we address the range of imaging techniques currently in clinical practice and those under development. Significant advances in high‐field MRI and micro‐focus CT imaging show particular promise for smaller and earlier gestation foetuses. We also review how MRI biomarkers such as diffusion‐weighted imaging and organ volumetric analysis may aid diagnosis and image interpretation in the absence of autopsy data. Three‐dimensional printing and augmented reality may help make imaging findings more accessible to parents, colleagues and trainees.
Long‐term monitoring of sporadic permafrost at the eastern margin of the European Alps (Hochreichart, Seckauer Tauern range, Austria)
Authors: Kellerer‐Pirklbauer Andreas 
Published: September 2019

AbstractDelineating the spatial extent and the altitudinal lower limit of mountain permafrost is difficult due to complex topo‐climatic and variable ground thermal conditions within short distances. Little information exists regarding sporadic permafrost existence, its thermal characteristics and its long‐term changes at the eastern margin of the European Alps. To reduce this gap, permafrost monitoring was initiated in 2004 in the Seckauer Tauern mountains, Austria. Research was carried out in the summit region of Mt Hochreichart (2416 m a.s.l.) and at several nearby cirques and valleys, all with rock glaciers. Geomorphic mapping, numerical permafrost modeling, measurements of the bottom temperature of the winter snow cover, continuous ground temperature monitoring, electrical resistivity tomography and optical snow cover monitoring were applied. Results indicate sporadic permafrost occurrence in the summit region with mean annual ground temperatures slightly below 0°C at the surface and −1.4°C at 2.5 m depth. Permafrost lenses also exist in the transition zone between the rock glacier and the talus slope behind attributed to coarse‐grained, blocky material causing additional ground cooling. Thanks to long‐term data, statistically significant trends of atmospheric and ground warming were observed in 2000–2018. Permafrost at this site will presumably disappear within the next few decades.
Metrics‐driven decision‐making improves performance at a complex process facility
Authors: Diaz Elise , Watts Murray 
Published: September 2019

AbstractThe importance of using leading and lagging metrics to drive improvement in process safety performance at complex process facilities has been well documented. Organizations are challenged to develop an appropriate set of metrics that will provide a holistic view of process safety management system health to allow for corrective action against poor performance. This article will share a new complex process facility's journey in establishing leading and lagging metrics, the metric review cycle applied to drive improvement, and examples of these improvements.
Efficacy of four vaginal progesterones for luteal phase support in frozen‐thawed embryo transfer cycles: A randomized clinical trial
Authors: Shiba Reiko , Kinutani Masayuki , Okano Shinichiro , Kawano Reo , Kikkawa Yuko 
Published: September 2019

AbstractPurposeTo investigate the efficacy of four vaginal progesterones, Lutinus, Utrogestan, Luteum, and Crinone, as luteal phase support (LPS) in frozen‐thawed embryo transfer (Frozen‐ET) cycles.MethodsPatients undergoing autologous Frozen‐ET of one cleavage‐stage embryo or one blastocyst. Two hundred fifty‐nine Frozen‐ET cycles were randomized to four groups for LPS: Lutinus, Utrogestan, Luteum, and Crinone. The clinical pregnancy rate (CPR), fetal heartbeat rate (FHR), and miscarriage rate (MR) were analyzed using the Mann‐Whitney or Kruskal‐Wallis test and Fisher exact test.ResultsTwo hundred thirty‐five Frozen‐ET cycles were analyzed: 63 cycles in the Lutinus group, 60 in the Utrogestan group, 56 in the Luteum group, and 56 in the Crinone group. No significant differences were observed between the four groups in CPR (Lutinus, Utrogestan, Luteum, and Crinone: 34.9%, 33.3%, 37.5%, and 35.7%, respectively; P = .976), FHR (26.9%, 31.6%, 30.3%, and 25.0%, respectively; P = .857), and MR (31.8%, 10.0%, 19.0%, and 30.0%, respectively; P = .306). Multivariate logistic regression analysis also revealed that there were no statistically significant differences between the four groups with regard to CPR, FHR, and MR.ConclusionThere was no clinically significant difference in pregnancy outcomes between the four vaginal progesterone groups for LPS in Frozen‐ET cycles.
Copper‐Catalyzed Intramolecular N‐Arylation of Dihalobenzene and Amine‐Trichloroacetonitrile Adduct under Ultrasound‐Irradiation
Authors: Nematpour Manijeh , Fasihi Dastjerdi Hossein , Mahboubi Rabbani Sayyed Mohammad Ismaeil , Tabatabai Sayyed Abbas 
Published: September 2019

AbstractA novel series of 2‐(trichloromethyl)‐1H‐ benzo[d]imidazole analogs were synthesized via an ultrasonic‐assisted, one‐pot, copper‐catalyzed three‐component reaction of the amine‐trichloroacetonitrile adduct and 1, 2‐dihalo benzene at room temperature. Affordable starting materials, simple work‐up method, short reaction time process and relatively high yields were the advantages of this modified version of Ullmann reaction.
Selective Production of 1,3‐Diethylbenzene by Electrocatalytic Hydrocracking of Bamboo Lignin in Alkaline Solution
Authors: Shen Dayu , Yu Xueqing , Yuan Lu , Zhang Songmei , Li Gang 
Published: September 2019

AbstractThis study proposed a novel procedure for the selective production of 1,3‐diethylbenzene (m‐DEB) by the electrocatalytic hydrocracking of bamboo lignin in alkaline solution. The electrocatalytic reaction was carried out in the fixed bed three‐dimensional electrode reactor, which consisted of Ti/SnO2‐Sb2O3/α‐PbO2/β‐PbO2 anode, copper mesh cathode, and ceramic particles that filled between the anode and cathode. Under the optimal conditions of 50 g/L lignin in NaOH solution (0.5 mol/L), a current density of 25 mA/cm2, a temperature of 25 °C, and reaction time of 10 h, bamboo lignin was completely decomposed and an accumulated total yield of 35.7 g/L was obtained. Furthermore, the accumulated yield of m‐DEB reached a maximum of 0.361 g/g‐lignin by using a lignin concentration of 30 g/L. In addition, the formation of m‐DEB was a zero‐order kinetic reaction.
Applications of Catalytic Hairpin Assembly Reaction in Biosensing
Authors: Liu Jumei , Zhang Ye , Xie Huabin , Zhao Li , Zheng Lei , Ye Huiming 
Published: September 2019

AbstractNucleic acids are considered as perfect programmable materials for cascade signal amplification and not merely as genetic information carriers. Among them, catalytic hairpin assembly (CHA), an enzyme‐free, high‐efficiency, and isothermal amplification method, is a typical example. A typical CHA reaction is initiated by single‐stranded analytes, and substrate hairpins are successively opened, resulting in thermodynamically stable duplexes. CHA circuits, which were first proposed in 2008, present dozens of systems today. Through in‐depth research on mechanisms, the CHA circuits have been continuously enriched with diverse reaction systems and improved analytical performance. After a short time, the CHA reaction can realize exponential amplification under isothermal conditions. Under certain conditions, the CHA reaction can even achieve 600 000‐fold signal amplification. Owing to its promising versatility, CHA is able to be applied for analysis of various markers in vitro and in living cells. Also, CHA is integrated with nanomaterials and other molecular biotechnologies to produce diverse readouts. Herein, the varied CHA mechanisms, hairpin designs, and reaction conditions are introduced in detail. Additionally, biosensors based on CHA are presented. Finally, challenges and the outlook of CHA development are considered.
Boosting Interleukin‐12 Antitumor Activity and Synergism with Immunotherapy by Targeted Delivery with isoDGR‐Tagged Nanogold
Authors: Gasparri Anna Maria , Sacchi Angelina , Basso Veronica , Cortesi Filippo , Freschi Massimo , Rrapaj Eltjona , Bellone Matteo , Casorati Giulia , Dellabona Paolo , Mondino Anna , Corti Angelo , Curnis Flavio 
Published: September 2019

AbstractThe clinical use of interleukin‐12 (IL12), a cytokine endowed with potent immunotherapeutic anticancer activity, is limited by systemic toxicity. The hypothesis is addressed that gold nanoparticles tagged with a tumor‐homing peptide containing isoDGR, an αvβ3‐integrin binding motif, can be exploited for delivering IL12 to tumors and improving its therapeutic index. To this aim, gold nanospheres are functionalized with the head‐to‐tail cyclized‐peptide CGisoDGRG (Iso1) and murine IL12. The resulting nanodrug (Iso1/Au/IL12) is monodispersed, stable, and bifunctional in terms of αvβ3 and IL12‐receptor recognition. Low‐dose Iso1/Au/IL12, equivalent to 18–75 pg of IL12, induces antitumor effects in murine models of fibrosarcomas and mammary adenocarcinomas, with no evidence of toxicity. Equivalent doses of Au/IL12 (a nanodrug lacking Iso1) fail to delay tumor growth, whereas 15 000 pg of free IL12 is necessary to achieve similar effects. Iso1/Au/IL12 significantly increases tumor infiltration by innate immune cells, such as NK and iNKT cells, monocytes, and neutrophils. NK cell depletion completely inhibits its antitumor effects. Low‐dose Iso1/Au/IL12 can also increase the therapeutic efficacy of adoptive T‐cell therapy in mice with autochthonous prostate cancer. These findings indicate that coupling IL12 to isoDGR‐tagged nanogold is a valid strategy for enhancing its therapeutic index and sustaining adoptive T‐cell therapy.
Reducing the maintenance effort for parameterization of representative load tests using annotations
Authors: Schulz Henning , van Hoorn André , Wert Alexander 
Published: September 2019

SummaryDirectly affecting the user experience, performance is a crucial aspect of today's software applications. Representative load testing allows to effectively test and preserve the performance before delivery by mimicking the actually expected workload. In the literature, various approaches have been proposed for extracting representative load tests from recorded user sessions. However, these approaches require manual parameterization for specifying input data and adjusting static properties such as a request's domain name. This manual effort accumulates when load tests need to be updated due to changing production workloads and APIs.In this paper, we address the reduction of the maintenance effort for representative load testing. We introduce input data and properties annotations (IDPAs) that store manual parameterizations and can be evolved automatically. Experts only have to parameterize extracted load tests initially. For dealing with API changes, we develop approaches to evolve IDPAs for the types of changes described in the literature. We evaluated our approach in two experimental studies, by deriving effort estimation models, and in an industrial case study including four different software projects. Our evaluation shows that IDPAs can parameterize generated load tests for restoring the representativeness, especially for applications with workloads dominated by request orders and rates. The maintenance effort can be reduced from a quadratic cumulative effort over time to a linear cumulative effort for a typical mix of API changes. Furthermore, we were able to express all parameterizations required by the industrial projects using the IDPA but also had to integrate extensions using the provided extension mechanisms.
Substratum‐associated microbiota
Authors: Furey Paula C. , Liess Antonia , Lee Sylvia 
Published: September 2019

AbstractThis survey of 2018 literature on substratum‐associated microbiota presents brief highlights on research findings from primarily freshwaters, but includes those from a variety of aquatic ecosystems. Coverage of topics associated with benthic algae and cyanobacteria, though not comprehensive, includes new methods, taxa new to science, nutrient dynamics, trophic interactions, herbicides and other pollutants, metal contaminants, nuisance, bloom‐forming and harmful algae, bioassessment, and bioremediation. Coverage of bacteria, also not comprehensive, focused on methylation of mercury, metal contamination, toxins, and other environmental pollutants, including oil, as well as the use of benthic bacteria as bioindicators, in bioassessment tools and in biomonitoring. Additionally, we cover trends in recent and emerging topics on substratum‐associated microbiota of relevance to the Water Environment Federation.Practitioner pointsThis review of literature from 2018 on substratum‐associated microbiota presents highlights of findings on algae, cyanobacteria, and bacteria from primarily freshwaters.Topics covered that focus on algae and cyanobacteria include findings on new methods, taxa new to science, nutrient dynamics, trophic interactions, herbicides and other pollutants, metal contaminants, nuisance, bloomforming and harmful algae, bioassessment, and bioremediation. Topics covered that focus on bacteria include findings on methylation of mercury, metal contamination, toxins and other environmental pollutants, including oil, as well as the us e of benthic bacteria as bioindicators, in bioassessment tools and in biomonitoring.A brief presentation of new, noteworthy and emerging topics on substratum‐associated microbiota, build on those from 2017, to highlight those of particular relevance to the Water Environment Federation.
‘(Un)healthy Minds’ and Visual and Tactile Arts, c.1900–1950
Authors: Wiltshire Imogen 
Published: September 2019

AbstractThis chapter examines multifaceted intersections between art and mental health in the first half of the twentieth century. Art was an arena in which approaches to psychological health were not only produced and developed but also challenged and even exploited. While artwork by professional artists was conceptualised as having psychological benefits for viewers and visual and tactile art-making practices were formulated as occupational therapy and art therapy, concurrently some modern artists rejected the associations of a ‘healthy mind’ and appropriated mental illness for avant-garde ends. This chapter explores the function of art in shaping treatments and cultural perceptions both within and outside psychiatric institutions conventionally associated with defining and maintaining mental health.
The Myth of Dream-Hacking and ‘Inner Space’ in Science Fiction, 1948–2010
Authors: Mayo Rob 
Published: September 2019

AbstractChristopher Nolan’s 2010 filmInception was a commercial blockbuster and remains an enduring pop-culture reference point. Consciously or not, though, it enters into a thematic tradition which had already existed for over half a century. This essay traces a history, through literature, cinema and videogames from 1948 to 2010, of the theme of rendering a person’s mind as a physical ‘inner space’ which can be explored and interacted with by others. These creative works reflect contemporary society’s ideas and beliefs about how the mind works, how it may become damaged and how it may be fixed.
Challenging Psychiatric Classification: Healthy Autistic Diversity and the Neurodiversity Movement
Authors: Dyck Erika , Russell Ginny 
Published: September 2019

AbstractThis chapter explores the perspectives of members of the neurodiversity movement (NDM). ‘Neurodiversity’ is a concept that avoids the trappings of diagnostic language that distinguishes between healthy and unhealthy. Relying on the vocabulary of ‘neurotypical’ and ‘neurodivergent’ persons, the NDM promotes a more inclusive understanding of peoples’ states of mental health, consciousness, and, fundamentally, a way of being. We examine how the arguments of the NDM are reminiscent of other struggles within the broadly defined arena of disability activism, mad pride, and consumer-survivor movements and show how the NDM co-opts medical language to avoid the tradition developed by anti-psychiatrists who fundamentally reject psychiatry altogether.
An infrared bootstrap of the Schur index with surface defects
Authors: Fluder Martin , Longhi Pietro 
Published: September 2019

AbstractThe infrared formula relates the Schur index of a 4d$$ \mathcal{N} $$N= 2 theory to its wall-crossing invariant,a.k.a.BPS monodromy. A further extension of this formula, proposed by Córdova, Gaiotto and Shao, includes contributions by various types of line and surface defects. We study BPS monodromies in the presence of vortex surface defects ofarbitraryvorticity for general class$$ \mathcal{S} $$Stheories of typeA1engineered by UV curves with at least one regular puncture. The trace of these defect BPS monodromies is shown to coincide with the action of certainq-difference operators acting on the trace of the (pure) 4d BPS monodromy. We use these operators to develop a “bootstrap” (of traces) of BPS monodromies, relying only on their infrared properties, thereby reproducing the very general ultraviolet characterization of the Schur index.
Fine structure of Jackiw-Teitelboim quantum gravity
Authors: Blommaert Andreas , Mertens Thomas G. , Verschelde Henri 
Published: September 2019

AbstractWe investigate structural aspects of JT gravity through its BF description. In particular, we provide evidence that JT gravity should be thought of as (a coset of) the noncompact subsemigroup SL+(2,ℝ) BF theory. We highlight physical implications, including the famous Plancherel measure sinh 2π$$ \sqrt{E} $$E. Exploiting this perspective, we investigate JT gravity on more generic manifolds with emphasis on the edge degrees of freedom on entangling surfaces and factorization. It is found that the one-sided JT gravity degrees of freedom are described not just by a Schwarzian on the asymptotic boundary, but also include frozen SL+(2,ℝ) degrees of freedom on the horizon, identifiable as JT gravity black hole states. Configurations with two asymptotic boundaries are linked to 2d Liouville CFT on the torus surface.