bluuebunny/crossref_metadata_2025_split huggingface dataset:
Other Specified Feeding or Eating Disorders (OSFED): Clinical heterogeneity and cognitive-behavioral therapy outcome
Authors: Riesco Nadine , Agüera Zaida , Granero Roser , Jiménez-Murcia Susana , Menchón José M. , Fernández-Aranda Fernando 
Published: September 2018

AbstractBackground:with the DSM-5 new eating disorders (EDs) diagnostic subtypes were identified within the Other Specified Feeding or Eating Disorders (OSFED) category, which have so far been under-researched. Objectives of this study were to examine differential features among OSFED subtypes, exploring short-term cognitive-behavioral therapy (CBT) response and identifying clinical predictors of therapy outcome.Methods:the sample included 176 female patients diagnosed with OSFED [82 atypical anorexia nervosa (atypical-AN), 57 purging disorder (PD), and 37 subthreshold bulimia nervosa (sub-BN)]. Assessment included eating-related, psychopathological and personality measures.Results:results showed similar clinical and personality profiles between the diagnostic subtypes, with hardly any differences, only observable in the core symptoms of each diagnosis. The sub-BN group was the one which showed more social impairment. Regarding treatment outcome, the three groups did not reveal significant differences in remission rates, therapeutic adherence or dropout rates, reaching rates of dropout from 36.8% to 50% (p =.391). However, different ED subtype predictors appear related with full remission or dropout risk, specifically personality traits.Conclusions:our results suggest that OSFED patients may benefit similarly from the same CBT outpatient group approach. However, high dropout rates and low motivation seems to be an important limitation and challenge for future approaches.
Evidence for a Change in the Sex Ratio of Children Referred for Gender Dysphoria: Data From the Gender Identity Development Service in London (2000–2017)
Authors: de Graaf Nastasja M. , Carmichael Polly , Steensma Thomas D. , Zucker Kenneth J. 
Published: September 2018

Abstract

Introduction
The prevalence of gender dysphoria in children is not known; however, there are some data on the sex ratio of children referred to specialized gender identity clinics.

Aim
We sought to examine the sex ratio of children, and some associated factors (age at referral and year of referral), referred to the Gender Identity Development Service in the United Kingdom, the largest such clinic in the world.

Methods
The sex ratio of children (N = 1,215) referred to the Gender Identity Development Service between 2000–2017 was examined, along with year of referral, age-related patterns, and age at referral.

Main Outcome Measure
Sex ratio of birth-assigned boys vs birth-assigned girls.

Results
The sex ratio significantly favored birth-assigned boys over birth-assigned girls (1.27:1), but there were also age and year of referral effects. The sex ratio favored birth-assigned boys at younger ages (3–9 years), but favored birth-assigned girls at older ages (10–12 years). The percentage of referred birth-assigned boys significantly decreased when 2 cohorts were compared (2000–2006 vs 2007–2017). On average, birth-assigned boys were referred at a younger age than birth-assigned girls.

Clinical Implications
The evidence for a change in the sex ratio of children referred for gender dysphoria, particularly in recent years, matches a similar change in the sex ratio of adolescents referred for gender dysphoria. The reasons for this remain understudied.

Strength & Limitations
The United Kingdom data showed both similarities and differences when compared to data from 2 other gender identity clinics for children (Toronto, Ontario, Canada, and Amsterdam, The Netherlands). Such data need to be studied in more gender identity clinics for children, perhaps with the establishment of an international registry.

Conclusion
Further study of the correlates of the sex ratio for children referred for gender dysphoria will be useful in clinical care and management.
The Use of Transnational Labour Law in Steering Socially Responsible Corporate Governance towards Increased Worker Protection
Authors: Martin Isabelle 
Published: September 2018

AbstractSocially responsible corporate governance (SRCG) is a product of the interaction of corporate governance and corporate social responsibility. These two transnational business governance schemes have converged around the principles of accountability, sustainability, and due diligence. This article will examine to what extent SRCG can be useful in promoting worker protection. It will contend that, as a reflexive regulation, SRCG is normatively indeterminate and may easily be subject to regulatory capture by the traditional actors of corporate governance. This article will argue that these risks may be alleviated by the interaction of SRCG with transnational labour law (TLL). Transnational labour law increases SRCG’s responsiveness to the value of worker protection by offering labour more direct sources of participation to strengthen SRCG’s enforcement and alleviate risks of capture. Moreover, the principles of TLL weave a coherent and meaningful framework which can be used to assess the quality of the various corporate governance initiatives.
EFFECTS OF GREEN MANURES AND NPK FERTILIZER ON SOIL PROPERTIES, TOMATO YIELD AND QUALITY IN THE FOREST-SAVANNA ECOLOGY OF NIGERIA
Authors: AGBEDE TAIWO M. , ADEKIYA ARUNA O. , ALE MONDAY O. , EIFEDIYI EHIOKHILEN K. , OLATUNJI CHRISTY A. 
Published: September 2018

SUMMARYGreen manures (GM) as an alternative to inorganic fertilizer offer considerable potential as a source of plant nutrients and organic matter (OM). Hence, field experiments were carried out during 2015 and 2016 cropping seasons to compare impacts of GM and NPK (15:15:15) fertilizer on soil properties, growth, fruit yield, mineral, lycopene and vitamin C contents of tomato (Lycopersicon esculentumMill). GMs were composed by green tender stems and leaves of pawpaw (Carica papayaL.), neem (Azadirachta indicaA. Juss.), moringa (Moringa oleiferaLam.) or gliricidia (Gliricidia sepium(Jacq.) Kunth ex Walp.) and applied at 5 Mg ha−1, whereas NPK was applied at 300 kg ha−1and there was a no fertilizer plot (control). Application of GMs reduced soil bulk density and increased soil OM, N, P, K, Ca, Mg, growth, number of fruits and fruit yield of tomato compared with the control. NPK fertilizer had no effect on soil bulk density and soil OM, but it increased soil fertility and tomato yield as compared with the control. When comparing treatments, the highest tomato yield and best cost:benefit ratio were obtained with gliricidia as GM. The GMs and NPK fertilizer increased mineral, lycopene and vitamin C contents in tomato fruits and the highest K, Ca, Fe, Zn, Cu, lycopene and vitamin C contents in tomato fruits were found with moringa as GM. Our results revealed that GM has potential to improve soil properties, tomato yield and quality, being an alternative for cropping management.
THE ARCHITECTURE OF ENVIRONMENT: BUILDING HOUSES ALONG THE GREAT RIFT VALLEY IN JORDAN
Authors: Guarasci Bridget L. 
Published: September 2018

AbstractThis article analyzes the restoration of Jordan's UN Dana Biosphere Reserve cottages for ecotourism and home building in the neighboring village of Qadisiyya as competing land projects. Whereas a multimillion-dollar endowment from the United States Agency for International Development (USAID) restores Dana's houses as a “heritage” village for a tourist economy, families in Qadisiyya build houses with income from provisional labor to shore up a familial future. Each act of home building articulates a political claim to land. This article argues for attention to the architecture of the environment in the comparison of two, once-related villages. A comparative analysis of Dana and Qadisiyya reveals the competing socio-political objectives of home building for the future of Jordan and the implications of environment in that struggle.
REMEMBERING ZINGAL: STATE, CITIZENS, AND FORESTS IN TURKEY
Authors: Özkan Hande 
Published: September 2018

AbstractThis article analyzes Turkish forestry as a site of nation building. To understand the ways in which forestry shaped ideas of the state and citizenship, I explore the history and memories of the forestry enterprise, Zingal, from the early 20th century to the present. I argue that the conflicting narratives around Zingal in archives and memory are symptoms of the contradictions inherent to nationalist modernity. I also reveal the continuation of similar contradictions in the 21st century by showing how citizens’ discourse of resentment over deindustrialization can coexist with their objection to a potential nuclear industry.
Immediate selective laryngeal reinnervation in vagal paraganglioma patients
Authors: Mat Baki M , Clarke P , Birchall M A 
Published: September 2018

AbstractObjectiveThis prospective case series aimed to present the outcomes of immediate selective laryngeal reinnervation.MethodsTwo middle-aged women with vagal paraganglioma undergoing an excision operation underwent immediate selective laryngeal reinnervation using the phrenic nerve and ansa cervicalis as the donor nerve. Multidimensional outcome measures were employed pre-operatively, and at 1, 6 and 12 months post-operatively.ResultsThe voice handicap index-10 score improved from 23 (patient 1) and 18 (patient 2) at 1 month post-operation, to 5 (patient 1) and 1 (patient 2) at 12 months. The Eating Assessment Tool 10 score improved from 20 (patient 1) and 24 (patient 2) at 1 month post-operation, to 3 (patient 1) and 1 (patient 2) at 12 months. There was slight vocal fold abduction observed in patient one and no obvious abduction in patient two.ConclusionSelective reinnervation is safe to perform following vagal paraganglioma excision conducted on the same side. Voice and swallowing improvements were demonstrated, but no significant vocal fold abduction was achieved.
Anaesthesia for ear surgery in remote or resource-constrained environments
Authors: Kaur B , Clark M P A , Lea J 
Published: September 2018

AbstractBackgroundThe successful provision of middle-ear surgery requires appropriate anaesthesia. This may take the form of local or general anaesthesia; both methods have their advantages and disadvantages. Local anaesthesia is simple to administer and does not require the additional personnel required for general anaesthesia. In the low-resource setting, it can provide a very safe and effective means of allowing middle-ear surgery to be successfully completed. However, some middle-ear surgery is too complex to consider performing under local anaesthesia and here general anaesthesia will be required.ConclusionThis article highlights considerations for performing middle-ear surgery in a safe manner when the available resources may be more limited than those expected in high-income settings. There are situations where local anaesthesia with sedation may prove a useful compromise of the two techniques.
Estimating the risk of lung cancer and cardiac mortality from doses to the lung and heart from modern tangent-only breast radiotherapy
Authors: Georgiou Loukas A. , Farmer Adam F. 
Published: September 2018

AbstractPurposeThe Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) reported that the risks of breast cancer treatment in woman smokers may outweigh the benefits. The data used doses from published reports using a variety of treatment techniques. In our study, the risks of lung cancer and heart disease were determined from a modern era tangential-only technique.Methods and materialsDoses to the lung and heart were obtained for tangential radiotherapy to the breast or chest wall. The risk of lung cancer incidence and cardiac mortality were calculated by taking the ratio of our doses to those published by the EBCTG.ResultsA total of 77 women were identified meeting our inclusion criteria. The mean combined whole lung dose was 2·0 Gy. The mean whole heart dose was 0·9 Gy. The estimated risk of lung cancer and cardiac mortality in a 50-year-old life-long smoker was estimated to be 1·5 and <1%, respectively.ConclusionsTangential only radiotherapy delivered substantially lower doses to the combined whole lung and whole heart than those reported by the EBCTCG. In this cohort, the risks of radiation induced lung cancer and heart disease are outweighed by the benefits of radiotherapy even in those that are smokers.
Scaling-up reasoning and advanced analytics on BigData
Authors: CONDIE TYSON , DAS ARIYAM , INTERLANDI MATTEO , SHKAPSKY ALEXANDER , YANG MOHAN , ZANIOLO CARLO 
Published: September 2018

AbstractBigDatalog is an extension of Datalog that achieves performance and scalability on both Apache Spark and multicore systems to the point that its graph analytics outperform those written in GraphX. Looking back, we see how this realizes the ambitious goal pursued by deductive database researchers beginning 40 years ago: this is the goal of combining the rigor and power of logic in expressing queries and reasoning with the performance and scalability by which relational databases managed BigData. This goal led to Datalog which is based on Horn Clauses like Prolog but employs implementation techniques, such as semi-naïve fixpoint and magic sets, that extend the bottom-up computation model of relational systems, and thus obtain the performance and scalability that relational systems had achieved, as far back as the 80s, using data-parallelization on shared-nothing architectures. But this goal proved difficult to achieve because of major issues at (i) the language level and (ii) at the system level. The paper describes how (i) was addressed by simple rules under which the fixpoint semantics extends to programs using count, sum and extrema in recursion, and (ii) was tamed by parallel compilation techniques that achieve scalability on multicore systems and Apache Spark. This paper is under consideration for acceptance in Theory and Practice of Logic Programming.
Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis
Authors: Gautam Jaya , Banskota Suhrid , Lee Hyunji , Lee Yu-Jeong , Jeon Yong Hyun , Kim Jung-Ae , Jeong Byeong-Seon 
Published: September 2018

AbstractTriple-negative breast cancer (TNBC) is a highly metastatic breast cancer with poor prognosis. In the present study, we demonstrated that Src, a non-receptor tyrosine kinase, might provide an effective therapeutic strategy to overcome TNBC invasion and metastasis, which are mediated via the synergistic action of the lysosomal enzyme cathepsin S (CTSS) and gelatinase MMP-9. Knock-down of MMP-9 and CTSS using siRNAs resulted in a synergistic suppression of MDA-MB-231 cell invasion, which was similarly observed with pharmacological inhibitors. During the screening of new drug candidates that suppress both CTSS and MMP-9, BJ-2302, a novel 7-azaindolin-2-one derivative, was discovered. Src, an upstream activator of both pathways (PI3K/Akt and Ras/Raf/ERK) responsible for the expression of CTSS and MMP-9, was identified as a high-affinity target of BJ-2302 (IC90: 3.23 µM) through a Src kinase assay and a drug affinity responsive target stability (DARTS) assay. BJ-2302 effectively suppressed MDA-MB-231 cell invasion (Matrigel invasion assay) and metastasis (chorioallantoic membrane assay xenografted with MDA-MB-231-luc2-tdTomato cancer cells). Unlike Z-FL-COCHO (potent CTSS inhibitor), BJ-2302 did not induce any cytotoxicity in MCF-10A normal breast epithelial cells. Additionally, BJ-2302 (1 mg/kg) strongly suppressed TNBC cell proliferation in vitro and tumor growth in a xenograft mouse tumor model. The anti-metastatic and anti-tumor effects of BJ-2302 were superior to those of Z-FL-COCHO (1 mg/kg) or batimastat (30 mg/kg), a pan-MMP inhibitor. In summary, inhibition of Src kinase suppressed TNBC tumor growth and metastasis, and Src inhibitors such as BJ-2302 may constitute a novel therapeutic tool to treat breast cancer that expresses high levels of CTSS and MMP-9.
On-chip excitation of single germanium vacancies in nanodiamonds embedded in plasmonic waveguides
Authors: Siampour Hamidreza , Kumar Shailesh , Davydov Valery A. , Kulikova Liudmila F. , Agafonov Viatcheslav N. , Bozhevolnyi Sergey I. 
Published: September 2018

AbstractMonolithic integration of quantum emitters in nanoscale plasmonic circuitry requires low-loss plasmonic configurations capable of confining light well below the diffraction limit. We demonstrated on-chip remote excitation of nanodiamond-embedded single quantum emitters by plasmonic modes of dielectric ridges atop colloidal silver crystals. The nanodiamonds were produced to incorporate single germanium-vacancy (GeV) centres, providing bright, spectrally narrow and stable single-photon sources suitable for highly integrated circuits. Using electron-beam lithography with hydrogen silsesquioxane (HSQ) resist, dielectric-loaded surface plasmon polariton waveguides (DLSPPWs) were fabricated on single crystalline silver plates to contain those of deposited nanodiamonds that are found to feature appropriate single GeV centres. The low-loss plasmonic configuration enabled the 532-nm pump laser light to propagate on-chip in the DLSPPW and reach to an embedded nanodiamond where a single GeV centre was incorporated. The remote GeV emitter was thereby excited and coupled to spatially confined DLSPPW modes with an outstanding figure-of-merit of 180 due to a ~six-fold Purcell enhancement, ~56% coupling efficiency and ~33 μm transmission length, thereby opening new avenues for the implementation of nanoscale functional quantum devices.
Diabetes knowledge and its association with the weight status among residents of Jeddah City, Saudi Arabia
Authors: Kutbi Hebah A. , Mosli Hala H. , Alhasan Ahmed H. , Mosli Rana H. 
Published: September 2018

Abstract
Objective
To examine the association of weight status with level of diabetes knowledge (symptoms and complications) among residents of Jeddah City, Saudi Arabia.

Methods
In a cross-sectional study, a questionnaire assessing sociodemographic and health characteristics and knowledge about diabetes and its symptoms and complications was utilized. Data of 3978 adults, 18 years of age or older, were collected from public mall sites in Jeddah city and surrounding areas. Participants were divided into three tertiles based on their knowledge scores. Weight and height were measured following standardized procedures, and body weight categories were defined based on body mass index (BMI). The association between weight status and tertiles of diabetes knowledge was examined using multinomial logistic regression analysis.

Results
Compared to normal-weight participants, participants who were underweight, overweight, or obese, did not differ with regards to knowledge about diabetes symptoms. Adjusted models showed that overweight and obese participants had lower odds of being in the lowest tertile of knowledge about diabetes complications compared to normal-weight participants (OR: 0.71, 95% CI: 0.58–0.86 and OR: 0.64, 95% CI: 0.51–0.79, respectively). With regards to general knowledge about diabetes, the knowledge of participants who were underweight did not differ when compared to normal-weight participants. Overweight and obese participants had lower odds of being in the lowest tertile of general knowledge about diabetes compared to normal-weight participants (OR: 0.78, 95% CI: 0.62–0.97 and OR: 0.60, 95% CI: 0.47–0.76, respectively).

Conclusions
Overweight and obese individuals have better knowledge about diabetes compared to normal-weight individuals. Public health programs need to take into account the level of diabetes knowledge and tailor interventions to aid behavior and lifestyle change.
Alcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells
Authors: Ran Meihua , Chen Hui , Liang Bingyu , Liao Weibo , Jiang Junjun , Huang Jiegang , Ning Chuanyi , Zang Ning , Zhou Bo , Liao Yanyan , Liu Huifang , Qin Fengxiang , Yang Quanlue , Li Jieliang , Ho Wenzhe , Liang Hao , Ye Li 
Published: September 2018

AbstractBoth alcohol and hepatitis C virus (HCV) infection could induce cellular autophagy in liver cells, which is considered to be essential for productive HCV replication. However, whether alcohol-induced autophagy is involved in the pathogenesis of HCV infection is still poorly understood. Alcohol treatment could induce autophagy in Huh7 cells (a hepatoma cell line that supports HCV JFH-1 replication), evidenced by the increase of LC3B-II levels, the conversion of LC3B-I to LC3B-II, and the formation of GFP-LC3 puncta as well as the decrease of p62 level in alcohol-treated cells compared with control cells. Alcohol treatment also significantly increased PIASy (a member of the PIAS family) expression, which can act as a SUMO (small ubiquitin-like modifier protein) E3 ligase to regulate a broader range of cellular processes including autophagy. Overexpression or the silencing expression of PIASy in alcohol-treated Huh7 cells could increase or decrease autophagic activation caused by alcohol treatment, respectively, and thus affect HCV replication correspondingly. In the absence of alcohol, overexpression or silencing expression of PIASy increase or decrease the level of cellular autophagy, judged by the changes of LC3B-II and p62 levels in the presence or absence of chloroquine (CQ), a lysosome inhibitor. More importantly, in the presence of 3-methyladenine (3-MA), an inhibitor in the early stage of autophagy, the effects of overexpression or silencing expression of PIASy on HCV replication were largely blocked. Furthermore, PIASy could selectively drive the accumulation of SUMO1-conjugated proteins, along with upregulation of the expression of several important autophagy factors, including ATG7 and ATG5–ATG12. In conclusion, alcohol promotes HCV replication through activation of autophagy in Huh7 cells, which partly attributes to its induction of PIASy expression. PIASy-enhanced accumulation of SUMO1-conjugated proteins may contribute to its inducing effect of autophagy. Our findings provide a novel mechanism for the action of alcohol-promoting HCV replication in the context of cellular autophagy.
Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury
Authors: Zhu Qiang , Wang Han , Jiang Bin , Ni Xuhao , Jiang Longfeng , Li Changyong , Wang Xuehao , Zhang Feng , Ke Bibo , Lu Ling 
Published: September 2018

AbstractActivating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis. Activation of the mechanistic target of rapamycin (mTOR) and hypoxia-inducible factor (HIF) transcription factors are crucial for the regulation of immune cell function. Here, we investigated the mechanism by which the ATF3/mTOR/HIF-1 axis regulates immune responses in a liver ischemia/reperfusion injury (IRI) model. Deletion of ATF3 exacerbated liver damage, as evidenced by increased levels of serum ALT, intrahepatic macrophage/neutrophil trafficking, hepatocellular apoptosis, and the upregulation of pro-inflammatory mediators. ATF3 deficiency promoted mTOR and p70S6K phosphorylation, activated high mobility group box 1 (HMGB1) and TLR4, inhibited prolyl-hydroxylase 1 (PHD1), and increased HIF-1α activity, leading to Foxp3 downregulation and RORγt and IL-17A upregulation in IRI livers. Blocking mTOR or p70S6K in ATF3 knockout (KO) mice or bone marrow-derived macrophages (BMMs) downregulated HMGB1, TLR4, and HIF-1α and upregulated PHD1, increasing Foxp3 and decreasing IL-17A levels in vitro. Silencing of HIF-1α in ATF3 KO mice ameliorated IRI-induced liver damage in parallel with the downregulation of IL-17A in ATF3-deficient mice. These findings demonstrated that ATF3 deficiency activated mTOR/p70S6K/HIF-1α signaling, which was crucial for the modulation of TLR4-driven inflammatory responses and T cell development. The present study provides potential therapeutic targets for the treatment of liver IRI followed by liver transplantation.