bluuebunny/crossref_metadata_2025_split huggingface dataset:
OMERACT Filter 2.1: Elaboration of the Conceptual Framework for Outcome Measurement in Health Intervention Studies
Authors: Boers Maarten , Beaton Dorcas E. , Shea Beverley J. , Maxwell Lara J. , Bartlett Susan J. , Bingham Clifton O. , Conaghan Philip G. , D’Agostino Maria Antonietta , de Wit Maarten P. , Gossec Laure , March Lyn , Simon Lee S. , Singh Jasvinder A. , Strand Vibeke , Wells George A. , Tugwell Peter 
Published: February 2019

Objective.The Outcome Measures in Rheumatology (OMERACT) Filter 2.0 framework was developed in 2014 to aid core outcome set development by describing the full universe of “measurable aspects of health conditions” from which core domains can be selected. This paper provides elaborations and updated concepts (OMERACT Filter 2.1).Methods.At OMERACT 2018, we discussed challenges in the framework application caused by unclear or ambiguous wording and terms and incompletely developed concepts.Results.The updated OMERACT Filter 2.1 framework makes benefits and harms explicit, clarifies concepts, and improves naming of various terms.Conclusion.We expect that the Filter 2.1 framework will improve the process of core set development.
Core Domain Set Selection According to OMERACT Filter 2.1: The OMERACT Methodology
Authors: Maxwell Lara J. , Beaton Dorcas E. , Shea Beverley J. , Wells George A. , Boers Maarten , Grosskleg Shawna , Bingham Clifton O. , Conaghan Philip G. , D’Agostino Maria Antonietta , de Wit Maarten , Gossec Laure , March Lyn , Simon Lee S. , Singh Jasvinder A. , Strand Vibeke , Tugwell Peter 
Published: February 2019

Objective.To describe the Outcome Measures in Rheumatology (OMERACT) Filter 2.1 methodology for core domain set selection.Methods.The “OMERACT Way for Core Domain Set selection” framework consists of 3 stages: first, generating candidate domains through literature reviews and qualitative work, then a process of consensus to obtain agreement from those involved, and finally formal voting on the OMERACT Onion. The OMERACT Onion describes the placement of domains in layers/circles: mandatory in all trials/mandatory in specific circumstances (inner circle); important but optional (middle circle); or research agenda (outer circle). Five OMERACT working groups presented their core domain sets for endorsement by the OMERACT community. Tools including a workbook and whiteboard video were created to assist the process. The methods workshop at OMERACT 2018 introduced participants to this framework.Results.The 5 OMERACT working groups achieved consensus on their proposed core domain sets. After the Methodology Workshop training exercise at OMERACT 2018, over 90% of participants voted that they were confident that they understood the process of core domain set selection.Conclusion.The methods described in this paper were successfully used by the 5 working groups voting on domains at the OMERACT 2018 meeting, demonstrating the feasibility of the process. In addition, participants at OMERACT 2018 expressed increased confidence and understanding of the core domain set selection process after the training exercise. This methodology will continue to evolve, and we will use innovative technology such as whiteboard videos as a key part of our dissemination and implementation strategy for new methods.
Preliminary Definitions for Sacroiliac Joint Pathologies in the OMERACT Juvenile Idiopathic Arthritis Magnetic Resonance Imaging Score (OMERACT JAMRIS-SIJ)
Authors: Otobo Tarimobo M. , Conaghan Philip G. , Maksymowych Walter P. , van der Heijde Desiree , Weiss Pamela , Sudol-Szopinska Iwona , Herregods Nele , Jaremko Jacob L. , Meyers Arthur B. , Rumsey Dax , Inarejos Emilio C. , Kirkhus Eva , Stimec Jennifer , Panwar Jyoti , Thorpe Kevin , Jans Lennart , van Rossum M.A. , Tolend Mirkamal , Perez Manuela , Tzaribachev Nikolay , Sandhya Pulukool , Tse Shirley , Simone Appenzeller , Swami Vimarsha G. , Touma Zahi , Lambert Robert , Doria Andrea S. 
Published: February 2019

Objective.To develop definitions for the assessment of magnetic resonance imaging (MRI) pathologies of the sacroiliac joints (SIJ) in juvenile idiopathic arthritis.Methods.An Outcome Measures in Rheumatology (OMERACT) consensus-driven methodology consisting of iterative surveys and focus group meetings within an international group of rheumatologists and radiologists.Results.Two domains, inflammation and structural, were identified. Definitions for bone marrow edema, joint space inflammation, capsulitis, and enthesitis were derived for joint inflammation; sclerosis, erosion, fatty lesion, and ankylosis were defined for assessing structural joint changes.Conclusion.Preliminary consensus-driven definitions for inflammation and structural elements have been derived, underpinning the ongoing development of the OMERACT Juvenile Arthritis MRI SIJ scoring system (OMERACT JAMRIS-SIJ).
Patient Perspectives on DMARD Safety Concerns in Rheumatology Trials: Results from Inflammatory Arthritis Patient Focus Groups and OMERACT Attendees Discussion
Authors: Andersen Kathleen M. , Kelly Ayano , Lyddiatt Anne , Bingham Clifton O. , Bykerk Vivian P. , Batterman Adena , Westreich Joan , Jones Michelle K. , Cross Marita , Brooks Peter M. , March Lyn , Shea Beverley , Tugwell Peter , Simon Lee S. , Christensen Robin , Bartlett Susan J. 
Published: February 2019

Objective.The Outcome Measures in Rheumatology (OMERACT) Safety Working Group is identifying core safety domains that matter most to patients with rheumatic disease.Methods.International focus groups were held with 39 patients with inflammatory arthritis to identify disease-modifying antirheumatic drug (DMARD) experiences and concerns. Themes were identified by pragmatic thematic coding and discussed in small groups by meeting attendees.Results.Patients view DMARD side effects as a continuum and consider the cumulative effect on day-to-day function. Disease and drug experiences, personal factors, and life circumstances influence tolerance of side effects and treatment persistence.Conclusion.Patients weigh overall adverse effects and benefits over time in relation to experiences and life circumstances.
Characteristics of Circulating Natural Killer Cells and Their Interferon-γ Production in Active Adult-onset Still Disease
Authors: Shimojima Yasuhiro , Kishida Dai , Ueno Ken-ichi , Ushiyama Satoru , Ichikawa Takanori , Sekijima Yoshiki 
Published: February 2019

Objective.To investigate the characteristics of circulating natural killer (NK) cells and their interferon (IFN)-γ–producing ability in adult-onset Still disease (AOSD).Methods.Peripheral blood mononuclear cells were obtained from 22 patients in the acute phase of AOSD (acute AOSD); 7 of the 22 patients after treatment (remission AOSD), and 11 healthy controls (HC). NK cells and their IFN-γ expression levels were analyzed by flow cytometry. Additionally, the cytokine receptors of interleukin (IL)-12, IL-15, and IL-18 on NK cells were also evaluated.Results.The frequency of NK cells was significantly lower in acute AOSD than in HC. NK cell counts significantly increased in remission AOSD. Expression of IL-12 and IL-15 receptors on NK cells was significantly increased in acute AOSD, whereas that of IL-18 receptor indicated no significant difference among 3 groups. IFN-γ expression in NK cells was significantly higher in acute AOSD than in HC, and significantly decreased in remission AOSD. The absolute number of NK cells and IFN-γ–expressing NK cells revealed an inverse correlation with serum ferritin levels in acute AOSD. In 2 distinct subsets of NK cells, CD56dimNK cells significantly exhibited higher IFN-γ expression than CD56brightNK cells in acute AOSD.Conclusion.In acute AOSD, NK cells displayed lower proportion, whereas they had higher ability for IFN-γ production than in HC; moreover, upregulation of IL-12 and IL-15 receptors on NK cells may promote IFN-γ production. In addition, disease activity may be implicated in regulating the number of NK cells and IFN-γ–expressing NK cells in AOSD.
Sur l’intercorporéité et l’interanimalité Merleau-Ponty et la chair primordiale
Authors: Boccali Renato 
Published: February 2019

La philosophie de Merleau-Ponty est traversée par un questionnement constant du rapport entre nature et logos. Mais c’est seulement dans les cours des années 1956-1960 consacrés à la Nature que le rapport homme-animal trouve une articulation spécifique à l’intérieur d’un projet plus général d’esthésiologie ontologique. Merleau-Ponty montre que le corps esthésiologique est en relation d’intercorporéité avec la vie animale, selon un modèle de projection, d’introjection et de réinvestissement, qui exprime l’« étrange parenté » révélée par la configuration morphogénétique du vivant. En faisant donc appel à ces cours, j’essaierai de montrer le rôle central de la question de l’interanimalité en vue d’une ontologie de la vie, phénoménologiquement orientée.
Le jeu et la vie animale : la distinction du monde et du milieu au regard d’un comportement limite
Authors: Champlois Garance 
Published: February 2019

La distinction entre le monde et le milieu, bien davantage que la distinction entre l’âme et le corps, l’esprit et la machine, est centrale quand nous pensons la différence entre l’homme et l’animal. Cette distinction, si elle a bien une valeur heuristique jusqu’à un certain point, n’entraine-t-elle pas cependant des confusions, des raccourcis, qui obscurcissent toute une partie inexplorée de la vie animale ? Comment s’attaquer à un tel topos de la littérature sur le vivant, pour tâcher, non de le remettre radicalement en question, mais de le nuancer, de l’affiner, afin de saisir en quoi la distinction du monde et du milieu est en réalité bien plus poreuse qu’il n’y paraît ? C’est par l’étude phénoménologique – c’est-à-dire avant tout descriptive – d’un comportement spécifique, le jeu, que nous espérons faire apparaître les limites de cette distinction, et rendre possible une étude de la vie animale caractérisée comme virtuelle ; la notion même de virtuel s’en voit alors approfondie, car l’étude du jeu animal nous invite à la penser non plus dans des termes simplement psychologiques, mais à travers sa relation avec le corps. L’animal qui joue nous invite à penser un milieu virtuel, ouvert par ce que nous pourrions appeler un symbolisme du corps.
La téléologie cachée dans la pensée biologique d’Uexküll
Authors: Duicu Dragos 
Published: February 2019

L’article analyse les conséquences de l’adoption par Uexküll, dans sa conception de la vie animale, d’une vue transcendantaliste et subjectiviste qui est elle-même une réaction à l’objectivisme irréfléchi dominant la biologie au début du xx e siècle. Le résultat – cohérent mais surprenant – de cette surenchère du subjectivisme est la présence, chez Uexküll, d’une téléologie immanentiste, celle du plan éternel de la nature, dans lequel se trouvent prescrites et harmonisées les interactions des différents milieux monadiques des vivants.
Quantification of Retinal Nonperfusion Associated With Posterior Segment Neovascularization in Diabetic Retinopathy Using Ultra-Widefield Fluorescein Angiography
Authors: Baxter Sally L. , Ashir Aria , Nguyen Brian J. , Nudleman Eric 
Published: February 2019

BACKGROUND AND OBJECTIVE:
To quantify the size and location of nonperfusion associated with posterior segment neovascularization (NV) in proliferative diabetic retinopathy (PDR) using ultra-widefield fluorescein angiography.

PATIENTS AND METHODS:
Cross-sectional study of 18 eyes with PDR. The total image area, areas of nonperfusion, buds of posterior segment neovascularization (either neovascularization of the disc or elsewhere), and the distances from each bud to the nearest area of nonperfusion and to the disc were measured.

RESULTS:

Nonperfused areas with associated neovascularization were significantly larger than areas without neovascularization (32.0% ± 5.24% of the retinal image vs. 3.3% ± 0.92%;
P
< .001) and were more likely to be posteriorly located. Nonperfusion encompassing greater than 23% of the total angiographic image had more associated neovascular buds (9.64 ± 2.16 vs. 0.86 ± 0.29;
P
< .0001), which were closer to the disc (7.53 mm ± 0.27 mm vs. 9.24 mm ± 0.64 mm;
P
= .014).

CONCLUSION:
A threshold size of nonperfusion greater than 23% of the retinal image is associated with posterior segment neovascularization and may serve as an indicator of risk for the development of PDR.

[
Ophthalmic Surg Lasers Imaging Retina.
2019;50:86–92.]
L’évolution des industries en matières dures animales de l’âge du Bronze en Italie du Nord, à partir de l’étude des sites de Isera La Torretta, Molina di Ledro et Fiavé Carera en Trentin
Authors: Bazzanella Marta 
Published: February 2019

L’âge du Bronze en Italie du Nord se caractérise par la présence de deux phénomènes culturels : celui des sites de milieu humide de la culture de Polada, dans la région du lac de Garde, et celui des Terramare, les villages quadrangulaires fortifiés sur pilotis, qui occupent la vallée centrale du Pô. D’un point de vue chronologique, les villages de la culture de Polada se rapportent à l’âge du Bronze ancien et moyen, tandis que les Terramare se développent entre le Bronze moyen et le Bronze récent. Les habitats de cette période se sont mis en place dans des milieux humides, ce qui a permis la conservation optimale des industries en matières dures animales qui, bien que connues, ont souvent été très peu étudiées sous l’angle de leur évolution technologique et fonctionnelle. Le présent article traite de l’évolution techno-typologique des industries de l’âge du Bronze sur la base des données des sites Isera La Torretta, Molina di Ledro et Fiavé Carera du Trentin Haut-Adige en Italie du Nord.
De la campagne à la ville : évolution de l’artisanat des matières dures animales au Moyen Âge dans la France du Nord d’après les données archéologiques
Authors: Chaoui-Derieux Dorothée , Goret Jean-François 
Published: February 2019

L’évolution de l’artisanat des matières dures animales au Moyen Âge est encore largement méconnue, malgré la multiplication des fouilles préventives. La mise au jour fréquente de petits lots d’objets en os ou en bois de cervidé ne suffit pas à distinguer entre fabrication domestique et artisanat spécialisé itinérant, activité saisonnière et passe-temps, importation ou production locale… À partir de données provenant de la moitié nord de la France, une synthèse sera proposée sur cette question en mettant en lumière la mutation profonde liée à la naissance des corporations de métiers au xiiie siècle.
Tempestad en los Andes de Luis E. Valcárcel o el despertar del alma inca
Authors: López Pierre 
Published: February 2019

En 1927, Luis E. Valcárcel publica la obra Tempestad en los Andes, obra indigenista con una fuerte dimensión apologética y profética a veces amenazante. El autor aboga por un nuevo orden que surgirá con el despertar del indígena y actúa como un predicador que hace de su Andinismo un evangelio ; pero un evangelio que fue necesario, según él, para despertar las conciencias en un contexto político marcado por los discursos revolucionarios de izquierda.
Louis Bertrand, l’Orient et le militarisme
Authors: Bkhairia Hassen 
Published: February 2019

Cette étude s’intéresse à une figure de proue du nationalisme français de l’entre-deux-guerres, Louis Bertrand, romancier et essayiste qui, par son radicalisme, rappelle Maurice Barrès et Charles Maurras. Le propos est de mettre l’accent sur ses écrits militaristes – Devant l’islam, Le Sens de l’ennemi, Le Mirage oriental – qui rejettent l’idée de « fraternité universelle » et, au nom de la Nation, appellent à « se rebarbariser » pour pouvoir « [s’adapter] aux conditions du monde moderne, qui est, en grande partie, un monde barbare ». Une conception colonialiste associant l’altérité à une menace permanente qui suppose d’éclaircir la vision bertrandienne de l’orientalisme.
Soluble Fc-Disabled Herpes Virus Entry Mediator Augments Activation and Cytotoxicity of NK Cells by Promoting Cross-Talk between NK Cells and Monocytes
Authors: Meng Qinglai , Zaidi Asifa K. , Sedy John , Bensussan Armand , Popkin Daniel L. 
Published: February 2019

Abstract
CD160 is highly expressed by NK cells and is associated with cytolytic effector activity. Herpes virus entry mediator (HVEM) activates NK cells for cytokine production and cytolytic function via CD160. Fc-fusions are a well-established class of therapeutics, where the Fc domain provides additional biological and pharmacological properties to the fusion protein including enhanced serum t1/2 and interaction with Fc receptor–expressing immune cells. We evaluated the specific function of HVEM in regulating CD160-mediated NK cell effector function by generating a fusion of the HVEM extracellular domain with human IgG1 Fc bearing CD16-binding mutations (Fc*) resulting in HVEM-(Fc*). HVEM-(Fc*) displayed reduced binding to the Fc receptor CD16 (i.e., Fc-disabled HVEM), which limited Fc receptor–induced responses. HVEM-(Fc*) functional activity was compared with HVEM-Fc containing the wild type human IgG1 Fc. HVEM-(Fc*) treatment of NK cells and PBMCs caused greater IFN-γ production, enhanced cytotoxicity, reduced NK fratricide, and no change in CD16 expression on human NK cells compared with HVEM-Fc. HVEM-(Fc*) treatment of monocytes or PBMCs enhanced the expression level of CD80, CD83, and CD40 expression on monocytes. HVEM-(Fc*)–enhanced NK cell activation and cytotoxicity were promoted via cross-talk between NK cells and monocytes that was driven by cell–cell contact. In this study, we have shown that soluble Fc-disabled HVEM-(Fc*) augments NK cell activation, IFN-γ production, and cytotoxicity of NK cells without inducing NK cell fratricide by promoting cross-talk between NK cells and monocytes without Fc receptor–induced effects. Soluble Fc-disabled HVEM-(Fc*) may be considered as a research and potentially therapeutic reagent for modulating immune responses via sole activation of HVEM receptors.
Syncrisis as literary motif in the story about the grown-up child Jesus in the temple (Luke 2:41–52 and the Thomas tradition)
Authors: Van Aarde Andries G. 
Published: February 2019

Syncrisis as literary motif in the story about the grown-up child Jesus in the temple (Lk 2:41–52 and the Thomas tradition): The article explores hermeneutical solutions for the negative response from the child Jesus towards his biological parents in the Lukan temple story (Lk 2:41–52). The ‘wisdom’ of the child who acts in an ‘adult-like’ way is interpreted as a syncrisis. This literary motif is explained by an analysis of the contrasting positive and negative acts of the child Jesus towards teachers of the Torah in the Infancy Gospel of Thomas.
Correcting atmospheric CO2 and CH4 mole fractions obtained with Picarro analyzers for sensitivity of cavity pressure to water vapor
Authors: Reum Friedemann , Gerbig Christoph , Lavric Jost V. , Rella Chris W. , Göckede Mathias 
Published: February 2019

Abstract. Measurements of dry air mole fractions of atmospheric
greenhouse gases are used in inverse models of atmospheric tracer transport
to quantify their sources and sinks. The measurements have to be calibrated
to a common scale to avoid bias in the inferred fluxes. For this purpose,
the World Meteorological Organization (WMO) has set requirements for the
interlaboratory compatibility of atmospheric greenhouse gas (GHG)
measurements. A widely used series of devices for these measurements are the
GHG analyzers manufactured by Picarro, Inc. These are often operated in
humid air, and the effects of water vapor are corrected for in
post-processing. Here, we report on rarely detected and previously
unexplained biases of the water correction method for CO2 and CH4
in the literature. They are largest at water vapor mole fractions below 0.5 % H2O, which were undersampled in previous studies, and can
therefore affect measurements obtained in humid air. Setups that dry sample
air using Nafion membranes may be affected as well if there are differences
in residual water vapor levels between sample and calibration air. The
biases are caused by a sensitivity of the pressure in the measurement cavity
to water vapor. We correct these biases by modifying the water correction
method from the literature. Our method relies on experiments that maintain
stable water vapor levels to allow equilibration of cavity pressure. In our
experiments with the commonly used droplet method, this requirement was not
fulfilled. Correcting CO2 measurements proved challenging, presumably
because of our humidification method. Open questions pertain to differences
among analyzers and variability over time. In our experiments, the biases
amounted to considerable fractions of the WMO interlaboratory compatibility
goals. Since measurements of dry air mole fractions of CO2 and CH4
are also subject to other uncertainties, correcting the cavity
pressure-related biases helps keep the overall accuracy of measurements
obtained with Picarro GHG analyzers in humid and potentially in Nafion-dried
air within the WMO goals.
The Lituya Bay landslide-generated mega-tsunami – numerical simulation and sensitivity analysis
Authors: González-Vida José Manuel , Macías Jorge , Castro Manuel Jesús , Sánchez-Linares Carlos , de la Asunción Marc , Ortega-Acosta Sergio , Arcas Diego 
Published: February 2019

Abstract. The 1958 Lituya Bay landslide-generated
mega-tsunami is simulated using the Landslide-HySEA model, a recently
developed
finite-volume Savage–Hutter shallow water coupled numerical model.
Two factors are crucial if the main objective of the numerical simulation is
to reproduce the maximal run-up with an accurate simulation of the inundated
area and a precise recreation of the known trimline of the 1958 mega-tsunami
of Lituya Bay: first, the accurate reconstruction of the initial slide and then
the choice of a suitable coupled landslide–fluid model able to reproduce how
the energy released by the landslide is transmitted to the water and then
propagated. Given the numerical model, the choice of parameters appears to be
a point of major importance, which leads us to perform a sensitivity analysis.
Based on public domain topo-bathymetric data, and on information extracted
from the work of Miller (1960), an approximation of Gilbert Inlet
topo-bathymetry was set up and used for the numerical simulation of the
mega-event. Once optimal model parameters were set, comparisons with
observational data were performed in order to validate the numerical results.
In the present work, we demonstrate that a shallow water type of model is
able to accurately reproduce such an extreme event as the Lituya Bay
mega-tsunami. The resulting numerical simulation is one of the first
successful attempts (if not the first) at numerically reproducing, in detail,
the main features of this event in a realistic 3-D basin geometry, where no
smoothing or other stabilizing factors in the bathymetric data are applied.