bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Radical Economic Restructuring in Truancy from School and Engagement in Crime
Authors: Farrall Stephen , Gray Emily , Mike Jones Philip 
Published: May 2019

AbstractOf late, criminologists have become acutely aware of the relationship between school outcomes and engagement in crime as an adult. This phenomenon—which has come to be known as the ‘school-to-prison-pipeline’—has been studied in North America and the United Kingdom, and requires longitudinal data sets. Typically, these studies approach the phenomenon from an individualist perspective and examine truancy in terms of the truants’ attitudes, academic achievement or their home life. What remains unclear, however, is a consideration of (1) how macro-level social and economic processes may influence the incidence of truancy, and (2) how structural processes fluctuate over time, and in so doing produce variations in truancy rates or the causal processes associated with truancy. Using longitudinal data from two birth cohort studies, we empirically address these blind spots and test the role of social-structural processes in truancy, and how these may change over time.
Social Work With Unaccompanied Asylum-Seeking Young People: Reframing Social Care Professionals As ‘Co-Navigators’
Authors: Devenney Kelly 
Published: May 2019

AbstractThis article explores the relationships between unaccompanied asylum-seeking young people and the social care professionals who work with them. Based on the interviews with both young people and professionals, analysed using a thematic narrative approach, the findings seek to reframe practitioners in this field as ‘co-navigators’. Such co-navigators assist asylum-seeking young people to plot a course through complex and uncertain social terrain, including the shifting and inhospitable terrain of immigration regimes. Viewing practice in this way brings into focus the interplay of agency and control in these relationships. In contrast to some previous conceptualisations, the agency of the young people here is expressed through relationships with professionals as many of the young people relied on social care to help them manifest their goals and aspirations; both through pragmatic assistance in navigating the complexity of institutional bureaucracy and through developing emotional, therapeutic bonds. Understanding social care professionals as ‘co-navigators’ allows us to understand the emotional value of practical forms of assistance as well as explore how agency might operate as such relationships evolve.
Improved Meet-in-the-Middle Attacks on Reduced-Round Kiasu-BC and Joltik-BC
Authors: Liu Ya , Shi Yifan , Gu Dawu , Zeng Zhiqiang , Zhao Fengyu , Li Wei , Liu Zhiqiang , Bao Yang 
Published: May 2019

AbstractKiasu-BC and Joltik-BC are internal tweakable block ciphers of authenticated encryption algorithms Kiasu and Joltik submitted to the CAESAR competition. Kiasu-BC is a 128-bit block cipher, of which tweak and key sizes are 64 and 128 bits, respectively. Joltik-BC-128 is a 64-bit lightweight block cipher supporting 128 bits tweakey. Its designers recommended the key and tweak sizes are both 64 bits. In this paper, we propose improved meet-in-the-middle attacks on 8-round Kiasu-BC, 9-round and 10-round Joltik-BC-128 by exploiting properties of their structures and using precomputation tables and the differential enumeration. For Kiasu-BC, we build a 5-round distinguisher to attack 8-round Kiasu-BC with $2^{109}$ plaintext–tweaks, $2^{112.8}$ encrytions and $2^{92.91}$ blocks. Compared with previously best known cryptanalytic results on 8-round Kiasu-BC under chosen plaintext attacks, the data and time complexities are reduced by $2^{7}$ and $2^{3.2}$ times, respectively. For the recommended version of Joltik-BC-128, we construct a 6-round distinguisher to attack 9-round Joltik-BC-128 with $2^{53}$ plaintext–tweaks, $2^{56.6}$ encryptions and $2^{52.91}$ blocks, respectively. Compared with previously best known results, the data and time complexities are reduced by $2^7$ and $2^{5.1}$ times, respectively. In addition, we present a 6.5-round distinguisher to attack 10-round Joltik-BC-128 with $2^{53}$ plaintext–tweaks, $2^{101.4}$ encryptions and $2^{76.91}$ blocks.
Mechanotransduction, immunoregulation, and metabolic functions of CD31 in cardiovascular pathophysiology
Authors: Caligiuri Giuseppina 
Published: May 2019

AbstractBiomechanical changes in the heart and vessels drive rapid and dynamic regulation of blood flow, a vital process for meeting the changing metabolic needs of the peripheral tissues at any given point in time. The fluid movement of the blood exerts haemodynamic stress upon the solid elements of the cardiovascular system: the heart, vessels, and cellular components of the blood. Cardiovascular diseases can lead to prolonged mechanical stress, such as cardiac remodelling during heart failure or vascular stiffening in atherosclerosis. This can lead to a significantly reduced or increasingly turbulent blood supply, inducing a shift in cellular metabolism that, amongst other effects, can trigger the release of reactive oxygen species and initiate a self-perpetuating cycle of inflammation and oxidative stress. CD31 is the most abundant constitutive co-signalling receptor glycoprotein on endothelial cells, which line the cardiovascular system and form the first-line of cellular contact with the blood. By associating with most endothelial receptors involved in mechanosensing, CD31 regulates the response to biomechanical stimuli. In addition, by relocating in the lipid rafts of endothelial cells as well as of cells stably interacting with the endothelium, including leucocytes and platelets, CD31–CD31 trans-homophilic engagement guides and restrains platelet and immune cell accumulation and activation and at sites of damage. In this way, CD31 is at the centre of mediating mechanical, metabolic, and immunological changes within the circulation and provides a single target that may have pleiotropic beneficial effects.
Effects of Site Thermal Variation and Physiography on Flight Synchrony and Phenology of the North American Spruce Beetle (Coleoptera: Curculionidae, Scolytinae) and Associated Species in Colorado
Authors: Dell Isaac Hans , Davis Thomas Seth 
Published: May 2019

AbstractSpruce beetle, Dendroctonus rufipennis Kirby, is associated with forest mortality in Colorado and across western North America, yet it is not well understood how thermal variability affects basic population processes such as flight phenology. However, phenology–temperature relationships are important for understanding patterns of ecosystem disturbance, especially under projected climate warming. Here, we use a multiyear trapping study to test the hypothesis that spruce beetle flight synchrony, timing, and fitness traits (body size) are affected by variation in regional temperature and physiography. Large quantities of co-colonizing scolytines (Polygraphus convexifrons) (Coleoptera: Curculionidae, Scolytinae) and predatory beetles (Thanasimus undulatus) (Coleoptera: Cleridae) that may affect D. rufipennis populations also responded to spruce beetle synthetic pheromone lures. Relationships between flight patterns and environmental conditions were also analyzed for these species. The winter of 2018 was warmer and drier than winter 2017 and was associated with earlier flight for both scolytine species across most sites. The most important environmental factor driving D. rufipennis flight phenology was accumulated growing degree-days, with delayed flight cessation under warmer conditions and larger beetles following a warm winter. Flight was consistently more synchronous under colder growing season conditions for all species, but synchrony was not associated with winter temperatures. Warmer-than-average years promoted earlier flight of D. rufipennis and associated species, and less synchronous, prolonged flight across the region. Consequently, climate warming may be associated with earlier and potentially extended biotic pressure for spruce trees in the Rocky Mountain region, and flight phenology of multiple scolytines is plastic in response to thermal conditions.
Extra-anatomical ascending-thoraco-abdominal bypass for aortic fistula after thoracic endovascular aortic repair
Authors: Al Rstum Zain , Tanaka Akiko , Safi Hazim J , Estrera Anthony L 
Published: May 2019

Abstract
Aortobronchial and aorto-oesophageal fistulae after thoracic endovascular aortic repair (TEVAR) for traumatic aortic injuries are rare but serious. Potentially fatal complications may occur years after the stent graft deployment. Surgical management is challenging. We report on a 33-year-old male with aorto-oesophageal fistula and a 25-year-old male with aortobronchial fistula—both of whom received TEVAR for traumatic aortic injury. Each underwent successful staged open surgical repair with extra-anatomical bypass from the ascending aorta to the thoraco-abdominal aorta, along with arch vessel reconstructions and debridement of infected lesions. They remained alive after 18 months.
The impact of labial fixed appliance orthodontic treatment on patient expectation, experience, and satisfaction: an overview of systematic reviews
Authors: Yassir Yassir A , McIntyre Grant T , Bearn David R 
Published: May 2019

SummaryBackgroundPatient perception with fixed appliance orthodontic treatment is important to improve oral health-related quality of life.ObjectiveThe main objective of this study was to evaluate the impact of labial fixed appliance orthodontic care on patient perception before, during, and after the treatment.Search methodsRelevant systematic reviews investigating patient perception with fixed appliance orthodontic treatment were identified by searching electronic databases: MEDLINE via OVID (1946 to 31 December 2018), EMBASE (1974 to 31 December 2018), AMED (Allied and Complementary Medicine Database; 1985 to November 2018), PubMed (inception to 31 December 2018), Web of Science (1900 to 2018), and PsychINFO (1806 to 31 December 2018). Ongoing systematic reviews were searched using Prospero and a grey literature search was undertaken using Google Scholar and OpenGrey (www.opengrey.eu/). No language restriction was applied.Selection criteriaOnly studies investigating patient perception of fixed appliance orthodontic treatment were included.Data collection and analysisScreening, quality assessment [using the AMSTAR 2 tool (A Measurement Tool to Assess Systematic Reviews)], and data extraction were performed by two authors independently. Information was categorized and narratively synthesized for the key findings.ResultsA total of 163 articles investigating patient expectation, experience, and satisfaction with conventional ligation labial fixed orthodontic appliances were obtained. Of these, 152 observational or interventional studies were excluded, resulting in 11 eligible systematic reviews. Two were excluded as earlier reports of a Cochrane review. The quality of the reviews was variable (critically low, low, and moderate). The findings were as follows: aesthetics represents a primary motive for orthodontic treatment; a temporary deterioration in the quality of life occurs during the initial phases of treatment; gender and ethnicity factors do not have an impact on patient perception of treatment; and a positive relationship between orthodontist–patient–parent is important to achieve patient compliance and satisfaction.ConclusionsThere is a lack of high-quality studies in terms of systematic reviews and meta-analyses for assessing patient perception with fixed appliance orthodontic treatment. The aesthetic impact of malocclusion is the main motive for seeking orthodontic treatment. Quality of life reduces during the initial stages of orthodontic treatment but improves in the later stages of treatment. Assessment before, during, and after orthodontic treatment is necessary to comprehensively assess patient perception at all stages of care.Trial registrationCRD42019122653.Conflict of InterestNone to declare.
Prosocial Behaviour in Interethnic Encounters: Evidence from a Field Experiment with High- and Low-Status Immigrants
Authors: Zhang Nan , Aidenberger Amelie , Rauhut Heiko , Winter Fabian 
Published: May 2019

Abstract
Recent waves of immigration have changed the demographic face of European societies and fueled considerable debate over the consequences of ethnic diversity for social cohesion. One prominent argument in this debate holds that individuals are less willing to extend trust and solidarity across ethnic lines, leading to lower social capital in multiethnic communities. We present a direct test of this proposition in a field experiment involving native-immigrant interactions in Zurich's Central Train Station. Our intervention consists of approaching commuters with a small request for assistance (borrowing a mobile phone), which we take as a measure of prosociality. We further differentiate between reactions towards natives as well as both high- and low-status immigrant groups. Compared to native-native interactions, we find lower solidarity in native-immigrant encounters, especially in cases involving stereotypically low-status immigrants. In exploratory analyses, we further show that discrimination only obtains in 'low cost' situations where commuters could easily justify not helping (e.g. by claiming not to carry a phone). Overall our results shed light on key theoretical mechanisms underlying patterns of solidarity in contemporary multiethnic societies.
Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients
Authors: Wu Haodi , Yang Huaxiao , Rhee June-Wha , Zhang Joe Z , Lam Chi Keung , Sallam Karim , Chang Alex C Y , Ma Ning , Lee Jaecheol , Zhang Hao , Blau Helen M , Bers Donald M , Wu Joseph C 
Published: May 2019

Abstract

Aims
Diastolic dysfunction (DD) is common among hypertrophic cardiomyopathy (HCM) patients, causing major morbidity and mortality. However, its cellular mechanisms are not fully understood, and presently there is no effective treatment. Patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) hold great potential for investigating the mechanisms underlying DD in HCM and as a platform for drug discovery.

Methods and results
In the present study, beating iPSC-CMs were generated from healthy controls and HCM patients with DD. Micropatterned iPSC-CMs from HCM patients showed impaired diastolic function, as evidenced by prolonged relaxation time, decreased relaxation rate, and shortened diastolic sarcomere length. Ratiometric Ca2+ imaging indicated elevated diastolic [Ca2+]i and abnormal Ca2+ handling in HCM iPSC-CMs, which were exacerbated by β-adrenergic challenge. Combining Ca2+ imaging and traction force microscopy, we observed enhanced myofilament Ca2+ sensitivity (measured as dF/Δ[Ca2+]i) in HCM iPSC-CMs. These results were confirmed with genome-edited isogenic iPSC lines that carry HCM mutations, indicating that cytosolic diastolic Ca2+ overload, slowed [Ca2+]i recycling, and increased myofilament Ca2+ sensitivity, collectively impairing the relaxation of HCM iPSC-CMs. Treatment with partial blockade of Ca2+ or late Na+ current reset diastolic Ca2+ homeostasis, restored diastolic function, and improved long-term survival, suggesting that disturbed Ca2+ signalling is an important cellular pathological mechanism of DD. Further investigation showed increased expression of L-type Ca2+channel (LTCC) and transient receptor potential cation channels (TRPC) in HCM iPSC-CMs compared with control iPSC-CMs, which likely contributed to diastolic [Ca2+]i overload.

Conclusion
In summary, this study recapitulated DD in HCM at the single-cell level, and revealed novel cellular mechanisms and potential therapeutic targets of DD using iPSC-CMs.
A novel medical device coating prevents Staphylococcus aureus biofilm formation on medical device surfaces
Authors: Hogan Siobhan , Kasotakis Emmanouil , Maher Sean , Cavanagh Brenton , O'Gara James P , Pandit Abhay , Keyes Tia E , Devocelle Marc , O'Neill Eoghan 
Published: May 2019

ABSTRACT
Prevention of device related infections due to Staphylococcus aureus biofilms on devices represents a significant challenge. Such infections have recently been shown to be dependent on the coagulation pathway via activation of pro-thrombin and fibrin production. Three direct-thrombin inhibitors, argatroban, hirudin and dabigatran, were examined to determine their effect on preventing S. aureus biofilm on plastic biochip surfaces under shear stress using an in vivo relevant model of infection. Surface functionalization of polyurethane discs via dityrosine covalent crosslinking with hirudin was performed and changes in bacterial density and microscopic appearances determined. The three direct-thrombin inhibitors prevented S. aureus biofilm formation on plasma-coated surfaces treated with these agents. Coating of polyurethane with one of these agents, hirudin, significantly inhibited biofilm formation on the modified surface. These findings reveal the exciting potential for coating biomaterial surfaces with direct thrombin inhibitors to prevent staphylococcal binding and subsequent device-related infections.
Triglyceride-rich lipoprotein binding and uptake by heparan sulfate proteoglycan receptors in a CRISPR/Cas9 library of Hep3B mutants
Authors: Anower-E-Khuda Ferdous , Singh Gagandeep , Deng Yiping , Gordts Philip L S M , Esko Jeffrey D 
Published: May 2019

AbstractBinding and uptake of triglyceride-rich lipoproteins (TRLs) in mice depend on heparan sulfate and the hepatic proteoglycan, syndecan-1 (SDC1). Alteration of glucosamine N-sulfation by deletion of glucosamine N-deacetylase-N-sulfotransferase 1 (Ndst1) and 2-O-sulfation of uronic acids by deletion of uronyl 2-O-sulfotransferase (Hs2st) led to diminished lipoprotein metabolism, whereas inactivation of glucosaminyl 6-O-sulfotransferase 1 (Hs6st1), which encodes one of the three 6-O-sulfotransferases, had little effect on lipoprotein binding. However, other studies have suggested that 6-O-sulfation may be important for TRL binding and uptake. In order to explain these discrepant findings, we used CRISPR/Cas9 gene editing to create a library of mutants in the human hepatoma cell line, Hep3B. Inactivation of EXT1 encoding the heparan sulfate copolymerase, NDST1 and HS2ST dramatically reduced binding of TRLs. Inactivation of HS6ST1 had no effect, but deletion of HS6ST2 reduced TRL binding. Compounding mutations in HS6ST1 and HS6ST2 did not exacerbate this effect indicating that HS6ST2 is the dominant 6-O-sulfotransferase and that binding of TRLs indeed depends on 6-O-sulfation of glucosamine residues. Uptake studies showed that TRL internalization was also affected in 6-O-sulfation deficient cells. Interestingly, genetic deletion of SDC1 only marginally impacted binding of TRLs but reduced TRL uptake to the same extent as treating the cells with heparin lyases. These findings confirm that SDC1 is the dominant endocytic proteoglycan receptor for TRLs in human Hep3B cells and that binding and uptake of TRLs depend on SDC1 and N- and 2-O-sulfation as well as 6-O-sulfation of heparan sulfate chains catalyzed by HS6ST2.
Rethinking collaboration: developing a learning platform to address under-five mortality in Mpumalanga province, South Africa
Authors: D’Ambruoso Lucia , van der Merwe Maria , Wariri Oghenebrume , Byass Peter , Goosen Gerhard , Kahn Kathleen , Masinga Sparara , Mokoena Victoria , Spies Barry , Tollman Stephen , Witter Sophie , Twine Rhian 
Published: May 2019

Abstract
Following 50 years of apartheid, South Africa introduced visionary health policy committing to the right to health as part of a primary health care (PHC) approach. Implementation is seriously challenged, however, in an often-dysfunctional health system with scarce resources and a complex burden of avoidable mortality persists. Our aim was to develop a process generating evidence of practical relevance on implementation processes among people excluded from access to health systems. Informed by health policy and systems research, we developed a collaborative learning platform in which we worked as co-researchers with health authorities in a rural province. This article reports on the process and insights brought by health systems stakeholders. Evidence gaps on under-five mortality were identified with a provincial Directorate after which we collected quantitative and qualitative data. We applied verbal autopsy to quantify levels, causes and circumstances of deaths and participatory action research to gain community perspectives on the problem and priorities for action. We then re-convened health systems stakeholders to analyse and interpret these data through which several systems issues were identified as contributory to under-five deaths: staff availability and performance; service organization and infrastructure; multiple parallel initiatives; and capacity to address social determinants. Recommendations were developed ranging from immediate low- and no-cost re-organization of services to those where responses from higher levels of the system or outside were required. The process was viewed as acceptable and relevant for an overburdened system operating ‘in the dark’ in the absence of local data. Institutional infrastructure for evidence-based decision-making does not exist in many health systems. We developed a process connecting research evidence on rural health priorities with the means for action and enabled new partnerships between communities, authorities and researchers. Further development is planned to understand potential in deliberative processes for rural PHC.
Severe mtDNA depletion and dependency on catabolic lipid metabolism in DGUOK knockout mice
Authors: Zhou Xiaoshan , Curbo Sophie , Zhao Qian , Krishnan Shuba , Kuiper Raoul , Karlsson Anna 
Published: May 2019

Abstract
Deoxyguanosine kinase (DGUOK) provides guanosine and adenosine nucleotides for mitochondrial DNA (mtDNA) replication, and its deficiency in humans leads to hepatocerebral mtDNA depletion syndrome or to isolated hepatic disease. There are poor treatment options for DGUOK deficiency and the aim of this study was to generate a model for further studies of the disease that could reveal novel treatment strategies. We report a Dguok-deficient mouse strain that, similar to humans, is most severely affected in the liver. The Dguok complete knockout mice (Dguok−/−) were born normal, but began to lose weight at week 6. A change of fur color from black to blueish grey started at week 16 and was complete at week 20. The movements and behavior were indistinguishable compared to wild-type (wt) mice. A decrease of mtDNA copy number occurred in multiple tissues, with the liver being the most severely affected. The mtDNA-encoded protein cytochrome c oxidase was much lower in Dguok−/− liver tissue than in the wt, whereas the expression of the nuclear-encoded succinate dehydrogenase complex subunit A was unaffected. Histopathology showed severe alterations and immunohistochemistry showed signs of both oxidative stress and regeneration in Dguok−/− liver. The subcutaneous fat layer was undetectable in Dguok−/−, which, in addition to gene expression analysis, indicated an altered lipid metabolism. We conclude that Dguok has a major role for the synthesis of deoxyribonucleotides for mtDNA replication particularly in the liver, similar to the human disorder. Our data also show a catabolic lipid metabolism in liver tissue of Dguok−/−.