bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical simulation of the functionality of a stent structure for venous valve prostheses
Authors: Schubert Julia , Schümann Kerstin , Kischkel Sabine , Schmidt Wolfram , Grabow Niels , Stiehm Michael , Pfensig Sylvia , Schmitz Klaus-Peter , Keiler Jonas , Wree Andreas 
Published: September 2019

Abstract
Chronic venous insufficiency (CVI) is a common disease characterized by impaired venous drainage leading to congestion in the lower limbs. Currently, there are no artificial or biological venous valve prostheses commercially available. Previous minimally invasive design concepts failed to achieve sufficient long term results in animal or in vitro studies. The aim was to implement structural numerical simulation of clinically relevant loading cases for minimally invasive implantable venous valve prostheses. A bicuspid valve design was chosen as it showed superior results compared to tricuspid valves in previous studies. The selfexpanding support structure was developed by using diamond-shaped elements. Using finite-element analysis (FEA), various loading cases, including expansion and crimping of the stent structure and the release into a venous vessel, were simulated. A hyperelastic constitutive law for the vascular model was generated from uniaxial tensile test data of unfixated human vein walls. This study also compared numerical and experimental results regarding compliance and tensile tests to validate the vein material model. The calculated performance concerning expansion and crimping, as well as the release of the stent into a venous vessel, demonstrated the suitability of the stent design for minimally invasive application.
Actinomycin D for fibrosis management in ophthalmic implant surgery
Authors: Brietzke Andreas , Eickner Thomas , Grabow Niels , Reske Thomas , Matschegewski Claudia , Guthoff Rudolf , Stahnke Thomas 
Published: September 2019

Abstract
Implants that feature a drug delivery system loaded with antifibrotic active drugs provide a promising approach to address postoperative complications caused by fibrosis. This study is intended to clarify whether Actinomycin D has an impact specifically on components of the extracellular matrix (ECM) and its formation in human primary fibroblasts of the Tenon capsule (hTF). Furthermore, the suitability of this agent in poly(N-vinylpyrrolidone)- poly(methylmethacrylate)(PVP-co-PMMA) as a drug delivery model is evaluated in drug incorporation and release studies. RT-qPCR revealed a significant downregulation of the fibrotic marker genes ACTA2, COL1A1 and FN1 in cells stimulated with TGF- β1 and additionally treated with Actinomycin D. However, these findings could only be confirmed on α- SMA protein level. collagen I and Fibronectin synthesis stayed unaffected. The diffusion based incorporation of Actinomycin D into the polymer model proved to be very effective. The release of the agent was retarded with a slightly prolonged kinetic. These findings make Actinomycin D a promising antifibrotic agent in ophthalmic implant surgery.
Modeling of the Human Cerebral Collateral Circulation: Evaluation of the Impact on the Cerebral Perfusion in Case of Ischemic Stroke
Authors: Krames Lorena , Daschner Rosa , Lutz Yannick , Loewe Axel , Dössel Olaf , Cattaneo Giorgio 
Published: September 2019

Abstract
Stroke is the third-most cause of death in developed countries. A new promising treatment method in case of an ischemic stroke is selective intracarotid blood cooling combined with mechanical artery recanalization. However, the control of the treatment requires invasive or MRI-assisted measurement of cerebral temperature. An auspicious alternative is the use of computational modeling. In this work, we extended an existing 1D hemodynamics model including the characteristics of the anterior, middle and posterior cerebral artery. Furthermore, seven ipsilateral anastomoses were additionally integrated for each hemisphere. A potential stenosis was placed into the M1 segment of the middle cerebral artery, due to the highest risk of occlusion there. The extended model was evaluated for various degrees of collateralization (“poor”, “partial” and “good”) and degrees of stenosis (0%, 50%, 75% and 99.9%). Moreover, cerebral autoregulation was considered in the model. The higher the degree of collateralization and the degree of stenosis, the higher was the blood flow through the collaterals. Hence, a patient with a good collateralization could compensate a higher degree of occlusion and potentially has a better outcome after an ischemic stroke. For a 99.9% stenosis, an increased summed mean blood flow through the collaterals of +97.7% was predicted in case of good collateralization. Consequently, the blood supply via the terminal branches of the middle cerebral artery could be compensated up to 44.4% to the physiological blood flow. In combination with a temperature model, our model of the cerebral collateral circulation can be used for tailored temperature prediction for patients to be treated with selective therapeutic hypothermia.
Numerical simulation and in vitro examination of the flow behaviour within coronary stents
Authors: Melzer Helena-Sophie , Ahrens Ralf , Guber Andreas E. , Dohse Jakob 
Published: September 2019

Abstract
This paper discusses the influence of different design parameters of stents by mathematical flow simulations and flow measurements using micro-particle image velocimetry (micro-PIV). A stent strut may cause recirculation areas, which are considered to be the source of thrombosis and the process of in-stent restenosis. The simulations showed that a reduced strut height and a chamfering of the struts reduce these recirculation zones. The numerically determined results were compared with experimental investigations. For this purpose metallic stent structures were transferred into transparent channel systems made of PDMS. The experimental investigations confirm the results of numerical simulations.
Optical endovascular imaging combining endoscopy, NBI and OCT, a feasibility study
Authors: Boese Axel , Sivankutty Akhil Karthasseril , Friebe Michael 
Published: September 2019

Abstract
For imaging of the vascular structure, angiography is state of the art. This can be done by contrast enhanced XRay, CT or MR imaging. But these modalities typically only show the blood flow and do not allow a depiction of the vasculature itself. To provide information about the vessel walls and plaques narrowing the blood flow, catheter based intra vascular ultrasound or vascular optical coherence tomography can be used. Optical endoscopic imaging is rarely used in vascular diagnosis. But endoscopic imaging can depict superficial inflammations or defects of the intima vessel layer and the real anatomical shape of the inner vasculature e.g. at bifurcations or aneurysms. Since OCT and endoscopic imaging both need a flushing to remove the blood for a short time, a combination of both modalities seems viable. For combining the two modalities, various background studies were performed including the selection of a feasible fibre endoscope, light source and camera system. A new pull-back and flushing device was designed and created for realizing the synchronous image acquisition using the two modalities. For calibration of the system and definition of the pullback and imaging parameters, first tests on artificial phantoms were performed. Then vascular and tissue models were imaged in a combined pullback mode after using the flush for complete blood removal. Endoscopic images were acquired in a video mode. The analysis of the images was done subjectively. As expected, the OCT provided structural information of the wall. The endoscopic images in combination with pullback appear blurry in video mode. The flushing liquid hinders the automatic focusing of the camera. Thus, smaller details could not be identified but bifurcations were visible. Even though the results were not good as expected, the study showed the potential of a bimodal system and addressed the issues faced in the initial implementation.
Design of SiO2/TiO2 that Synergistically Increases The Hydrophobicity of Methyltrimethoxysilane Coated Glass
Authors: Widati Alfa Akustia , Nuryono Nuryono , Kartini Indriana 
Published: September 2019

AbstractThis research work presents the design of a mixture of SiO2/TiO2 that increases the surface roughness and hydrophobicity of methyltrimethoxysilane (MTMS) coated glass. The deposition of SiO2, TiO2, and MTMS were conducted using a layer by layer dip coating technique. The SiO2/TiO2 coating was derived from complete hydrolysis of tetraethylorthsilicate and titanium tetraisopropoxide. In order to evaluate and compare the performance of SiO2/TiO2/MTMS coated glass, the SiO2/SiO2/MTMS and TiO2/TiO2/MTMS were also fabricated. SiO2/TiO2/MTMS samples displayed the highest water contact angle. The topography of surfaces showed that SiO2/TiO2/MTMS exposed higher surface roughness with micro-nanoscale structures. The sequence of SiO2 and TiO2 influenced the water contact angle and the stability of the coatings. SiO2/TiO2/MTMS produced higher contact angle and stability than TiO2/SiO2/MTMS.
Exploring an Innovative Course Delivery Method for Accelerated BSN Students
Authors: Owens Rhoda A. 
Published: September 2019

Abstract

Background
The purpose of the pilot study was to develop and implement an innovative hybrid-delivered professional development course and explore accelerated BSN student satisfaction and perceived learning.

Methods
The convenience sample consisted of 16 accelerated BSN students at one Midwestern university. The Student Evaluation of Learning and Feedback to Instructors online survey instrument used consisted of 21 five-point Likert-scale items.

Results
Students reported that the course was organized (M = 3.96) and promoted student learning (M = 4.53) and engagement (M = 3.97). Graded material was adequate (M = 4.31). The course created a supportive adult learning environment (M = 3.84) and instructor rapport (M = 4.47). Knowledge was applied during clinical experiences.

Conclusions
Hybrid courses can facilitate student learning and satisfaction. Further research is warranted to explore innovative hybrid course delivery methods with accelerated BSN students. It is critical to ensure quality education for this special nursing population.
Effect of home-based strength training program on IGF-I, IGFBP-1 and IGFBP-3 in obese Latino boys participating in a 16-week randomized controlled trial
Authors: Kelly Louise , Holmberg Patrick M. , Schroeder E. Todd , Loza Armando , Lin Xiao , Moody Alastai , Hughes Adrienne , Gibson Ann-Marie , Kirk Alison 
Published: September 2019

Abstract

Introduction
Growing evidence indicates that circulating concentrations of insulin-like growth factor 1 (IGF-I), along with IGF-I relative to IGF-binding proteins (IGFBP), are associated with an increased risk of cancer. In accord, regular exercise is linked with a lower risk of cancer.

Purpose
To assess the effects of a 16-week home-based strength training (HBST) program on serum IGF-I, IGFBP-1 and IGFBP-3.

Methods
A total of 32 obese Latino adolescent males (aged 14–18 years) were randomized into a twice-weekly HBST (n = 16) or a control group (C, n = 16) for 16 weeks. The following were measured at pre- and post-intervention: IGF-I, IGFBP-1 and IGFBP-3, glucose/insulin indices by oral and/or intravenous (IV) glucose tolerance tests, strength by one-repetition maximum (1RM), dietary intake by 3-d records, body composition by DEXA and physical activity using the Actigraph GT1X. The generalized linear model (GLM) was used to assess differences in changes among outcome measures between the HBST and C groups.

Results
Exercise adherence in the HBST group was 89%. IGF-1 showed a trend for significant within-subject improvements (p = 0.078) but no significant within-subject or between-subject differences for IGFBP-1, IGFBP-3 two-glucose, fasting glucose or 2-h glucose (p > 0.05). There was a significant decrease (p > 0.05) in fasting glucose in the C group (p = 0.02) and also in the intervention group (p = 0.03) between baseline and follow-up testing. A significant difference was also found in the C group for 2-h glucose with an increase at follow-up testing (p = 0.04).

Conclusions
Though not statistically significant (p < 0.05), the results indicated that a 16-week HBST program decreased IGF-I and increased IGFBP-1, along with IGFBP-3, concentrations among overweight/obese Latino boys. However, further studies should consider increasing either the dose or the duration of the intervention to elicit greater improvements in this at-risk pediatric population.
Effect of hemoglobin F and A2 on hemoglobin A1c determined by cation exchange high-performance liquid chromatography
Authors: Can Murat , Güven Berrak , Demir Akca Ayse Semra 
Published: September 2019

AbstractBackgroundThe potential effect of increase in hemoglobin (Hb) A2and HbF on glycated hemoglobin (HbA1c) measurements were investigated using a high-performance liquid chromatography (HPLC) method compared with an immunoturbimetric assay.MethodsSamples producing abnormal chromatograms during the measurement of routine HbA1ctesting with HPLC were further analyzed to characterize abnormal Hb variants. Patients were divided into three groups that had only high HbF (group 1), only high HbA2(group 2), and both high HbA2and HbF (group 3). HbA1cvalues of patients were re-assayed using the immunoturbidimetric method (Advia, Siemens Healthcare, Germany).ResultsHbA1clevels were significantly higher in all groups measured by immunoassay than in HPLC. We found a positive correlation between HPLC and immunoturbidimetry in the group 2 and a slight correlation in the group 1. There was no correlation between the two methods in group 3.ConclusionsHbA1cmeasurement by HPLC method interfering with elevated HbA2and HbF, especially HbF, should be verified by an immunoturbidimetric method.
PEDAGOGICAL REQUIREMENTS FOR THE IMPLEMENTATION OF DIFFERENTIATED APPROACH IN TEACHING ELEMENTARY SCHOOL CHILDREN
Authors: Dulmukhametova Gulnara Faridovna , Sirazieva Zarina Nailevna , Gali Gulnara Faritovna , Nicolaevna Usova Svetlana , Shamsutdinova Dilbar Valievna 
Published: September 2019

Purpose of the Study: The article describes the authors’ view on the model of the implementation of a differentiated approach in the training of elementary school children.
Methodology: In the research, the authors identify and systematize the pedagogical requirements for ensuring the sex differentiation in education of elementary school children, together forming a meaningful model for implementing a gender approach to the educational process of primary school and including gender education for students, teachers, and parents. The authors analyze the category of sex differentiation in domestic and foreign pedagogy.
Result: The authors theoretically describe the problem of implementing a differentiated approach in teaching elementary school children, and also substantiate the experimental work on testing the effectiveness of pedagogical conditions that interconnect and complement each other, forming a dynamic system that ensures the effective organization of the sex differentiation of elementary school children.
Application and Novelty: Presented pedagogical requirements and model of a gender approach to the educational process can solve the age and gender problems of elementary school children and harmonize their relationships. Data of the article can be used not only in the educational process of elementary school, but also at the lessons of such subjects as "Pedagogical psychology", "Developmental psychology", and "Differential psychology" at the university. These requirements give the opportunity
VALUES AND ANTI-VALUES IN FIGURATIVE PHRASEOLOGICAL UNITS IN THE RUSSIAN AND GERMAN LANGUAGES
Authors: Andreyeva Yelena Anatolyevna , Korneva Inna Germanovna , Sakhibullina Kadria Azatovna 
Published: September 2019

Purpose of the Study: The article discusses values and anti-values in the figurative phraseological units of the Russian and German languages. The object of the research is phraseological units of the Russian and German languages that have similar and specific images. The subject of the research is hedonistic and material-utilitarian values and anti-values contained in the Russian and German figurative phraseological units.
Methodology: The relevance of the study is due to the spiritual needs of modern society. The analysis of phraseological units in the axiological aspect is motivated by the anthropological orientation of modern linguistics where the language is considered in close connection with the consciousness and thinking of a person, their spiritual world, values, and anti-values. The research methods are the following: descriptive method, analysis of lexicographical interpretations, and etymology of the Russian and German phraseological units; the method of component analysis to research the structure of meaning of studied units; the method of conceptual and interpretative analysis.
Results: Hedonistic and material-utilitarian values and anti-values are represented by the Russian and German phraseological units that have similar images in their composition, which is due to the common source of the origin of phraseological units, and specific images associated with the Russian and German cultures.
Application: Research results can be helpful for the German language training and professional activities of translators and linguists.
INFLUENCE OF LOCUS OF CONTROL AND GENDER ON PROFESSIONAL JUDGMENT
Authors: Cheisviyanny Charoline , Dwita Sany , Helmy Herlina 
Published: September 2019

Purpose of this study: This study aims to prove the influence of locus of control (LoC) and gender on professional judgment.
Methodology: The population was professional accountants in Padang, represented by public accountants and accounting lecturers. The sampling technique used was the purposive sampling method. Totally, 69 respondents were selected as a sample in this study. The research data was obtained through questionnaires. Data were analyzed using the independent t-test.
Main Findings: The results of this study are: (1) There is no difference between male accountants and female accountants in giving judgments; (2) The second hypothesis (H2) cannot be concluded, because of the great differences in sizes between both the groups; (3) There is no difference among male accountants with internal and external LoC, and female accountants with internal LoC in giving judgments.
Application/Implication: The results are interesting since all the hypotheses were rejected. These findings implied that LoC and gender do not influence professional judgment because accountants have a code of ethics that guides them in making judgments. It suggests for further researches to add other variables such as culture or religiosity.
THE RELATIONSHIP BETWEEN ENVIRONMENTAL PERFORMANCE AND THE EXTENT OF ENVIRONMENTAL DISCLOSURE
Authors: Purwantini Cornelio , Faisal Faisal , Januarti Indira , Dwiatmoko Ignatius Aris 
Published: September 2019

Purpose of this study: This study examines the relationship between environmental performance and the extent of environmental disclosure.
Methodology: The sample of this study consists of 35 high profile companies. The environmental performance is measured based on the results of the assessment of PROPER and the extent of environmental disclosure index by using GRI checklist items. This research applies content analysis, descriptive, and inferential statistical analyses.
Main Findings: The result shows that the extent of environmental disclosure, on an average is low (22.5%). Mining companies provide the highest environmental disclosure (58.2%) followed by chemicals (21.4%), utilities (19.0%), pulp and papers (16.5%), industrial (11.0%), and oil and gas (4.2%). The analysis also presents that environmental performance does not affect the level of environmental disclosure.
Implications: This result suggests that high environmental performance may not encourage companies to communicate more environmental issues. This finding indicates that motivation for a company to disclose environmental information is not always based on the legitimacy perspectives, but might be an accountability form.
EMPOWERING STUDENTS TO BECOME EFFECTIVE LEARNERS THROUGH ACTIVITY BASED LEARNING
Authors: Kanchana Dr. S , Patchainayagi Dr. S , Rajkumar Dr. S 
Published: September 2019

Purpose of the study: Activity based learning helps students to learn actively in classroom and it also provides ample scope for experimental learning. Students are to be provided opportunities and optimum learning environment to explore their knowledge and skills. It would broaden the understanding of concepts and theories in their core premises. It enhances the learning process and the students as active learners.
Methodology: Interactive learning strategies are categorized as individual learning and group learning strategies. Individual activities may include flipped learning, polling answers and questions. Group activities include pair and share strategy, inspire and initiate scenarios.
Main Findings: Interactive learning strategies, E-Learning and M-Learning are preferred modes for the students, promotes the cognitive level of the learners, achieved learning objectives. It is essential to suggest and design innovative learning practices.
Implications: Higher education institutions and even schools are using various enhanced interactive learning practices, educational apps and M-Learning techniques. These activities enhance the student engagement in the classroom. By implementing activity based learning practices, learners become investigators and strive to make best real time decisions for different scenarios.
Novelty/Originality of this study: Enhanced learning strategies promotes cooperative learning and efficient for large group of learners.
Comparison of Payment Margins Between the Bundled Payments for Care Improvement Initiative and the Comprehensive Care for Joint Replacement Model Shows a Marked Reduction for a Successful Program
Authors: Padilla Jorge A. , Gabor Jonathan A. , Kalkut Gary E. , Pazand Lily , Zuckerman Joseph D. , Macaulay William , Bosco Joseph A. , Slover James D. 
Published: September 2019

Background:
The Comprehensive Care for Joint Replacement (CJR) model was implemented to address the 2 most commonly billed inpatient surgical procedures, total hip arthroplasty and total knee arthroplasty. The primary purpose of this study was to review the economic implications of 1 institution’s mandatory involvement in the CJR in comparison with prior involvement in the Bundled Payments for Care Improvement (BPCI) initiative.

Methods:
The mean cost per episode of care was calculated using our institution’s historical data. The target prices, projected savings or losses per episode of care, and projected annual savings for both BPCI and CJR were established and were comparatively analyzed.

Results:
The CJR target prices will decrease in comparison with BPCI target prices by 24.0% for Medicare Severity-Diagnosis Related Group (MS-DRG) 469 without fracture, 22.8% for MS-DRG 469 with fracture, 26.1% for MS-DRG 470 without fracture, and 27.7% for MS-DRG 470 with fracture, resulting in a reduction in savings per episode of care by 92.8% for MS-DRG 469 without fracture, 166.0% for MS-DRG 469 with fracture, 94.9% for MS-DRG 470 without fracture, and 61.7% for MS-DRG 470 with fracture. Our institution’s projected annual savings under CJR will decrease by 83.3%.

Conclusions:
These results suggest that the margin for savings in the CJR will be substantially reduced compared with the margin for savings in the BPCI. In hospitals that had previously devoted resources, these will have far less impact in the CJR, and hospitals new to the CJR that have not made these investments previously will require even greater resources for developing cost reduction and quality control strategies to remain financially solvent.

Level of Evidence:
Economic Level IV. See Instructions for Authors for a complete description of levels of evidence.