bluuebunny/crossref_metadata_2025_split huggingface dataset:
LRRK2 p.Ile1371Val Mutation in a Case with Neuropathologically Confirmed Multi-System Atrophy
Authors: Lee Kelsey , Nguyen Khanh-Dung , Sun Chao , Liu Mei , Zafar Faria , Saetern Jimmy , Flierl Adrian , Tetrud James W. , Langston J. William , Dickson Dennis , Schüle Birgitt 
Published: February 2018

Background: Mutations in the leucine rich repeat kinase 2 ( LRRK2) gene are among the most common genetic causes of Lewy body Parkinson’s disease (PD). However, LRRK2 mutations can also lead to a variety of pathological phenotypes other than typical PD, including relatively pure nigrostriatal cell loss without alpha-synuclein-positive Lewy bodies or Lewy neurites, progressive supranuclear palsy (PSP), and multiple system atrophy (MSA). The mechanisms behind this remarkable pleomorphic pathology are currently unclear. Objective: To genetically and pathologically characterize a case with a LRRK2, p.Ile1371Val rare variant and pathologically proven MSA. Methods: From the brain donation program at the Parkinson’s Institute and Clinical Center, we selected 26 brains with family history and a with clinicopathological diagnosis of PD ( n = 20), MSA ( n = 4), or PSP ( n = 2). We performed neuropathological evaluation, including alpha-synuclein and tau immunohistochemistry and sequenced 188 genes that have been reported as causative for or associated with neurodegenerative diseases. Results: We identified a known LRRK2, p.Ile1371Val genetic variant in a case with clinically diagnosed and pathologically proven MSA. Neuropathology revealed that the olivopontocerebellar system was more affected than the striatonigral system. Conclusions: Our data suggest that genetic variants in the LRRK2 gene can present clinically and neuropathologically as MSA. One other LRRK2 genetic variant ( LRRK2, p.Ile2020Thr) has been reported with a neuropathological diagnosis of MSA. Interestingly, the LRRK2 variant ( LRRK2, p.Ile1371Val) identified here has been reported previously in a postmortem case with Lewy body PD. Future studies are critical to discover the mechanisms leading to different neurodegenerative trajectories both in neuronal and glial cell populations.
Urinary Dysfunctions and Post-Void Residual Urine in Typical and Atypical Parkinson Diseases
Authors: Lee Yang-Hyun , Lee Jee-Eun , Ryu Dong-Woo , Oh Yoon-Sang , Lee Kwang-Soo , Hong Sung-Hoo , Kim Joong-Seok 
Published: February 2018

Background: Urinary dysfunction is relatively common, however, is often underestimated and diagnosed by subjective questionnaires in patients with Parkinsonism. Objective: To determine the correlation between subjective urinary dysfunction and post-void residual urine volume in patients with Parkinson’s disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and to assess the relationship between clinical characteristics and subjective or objective urinary dysfunction. Methods: A total of 196 patients with de novo Parkinsonism without urological and gynecological disorders were included. For all subjects, data were collected on sonographic post-void residual urine volume and urinary symptoms. All patients were also assessed on motor symptom severity, cognitive and affective measurements, other nonmotor symptoms, 39-item Parkinson’s Disease Questionnaire, and renal functions. Results: Seventeen out of 196 parkinsonian patients showed abnormal post-void residual urine volumes, with ≥100 ml. The MSA group showed significantly higher post-void residual urine volume compared to the PD and PSP groups. Symptoms of the sense of incomplete emptying, weak urine stream, and nocturia were strongly correlated with post-void residual urine volume. Post-void residual urine volume was positively related to autonomic symptoms, other non-motor symptoms, patient activities of daily living, and negatively related to renal function. Conclusion: Increased post-void residual urine volumes were observed in small portion of early drug-naïve Parkinsonian patients, especially in MSA. Post-void residual urine volume was significantly related to subjective urinary and other autonomic dysfunctions. Voiding dysfunction is associated with not only end organ damage, but also other nonmotor dysfunctions and patient activities of daily living.
Cardiovascular Risk Factor Burden in Veterans and Non-Veterans with Parkinson Disease
Authors: Kotagal Vikas , Albin Roger L. , Müller Martijn L.T.M , Bohnen Nicolaas I. 
Published: February 2018

Background: Medical comorbidities, including cardiovascular risk factors such as hypertension and diabetes, influence disease progression in Parkinson disease (PD) and may be variably present in different clinical populations. Objective/Methods: We conducted a retrospective nested case-control study of 29 Veterans with PD and 29 non-Veteran PD controls. The groups were matched for age, gender, and disease duration. Both groups underwent clinical and imaging testing as part of their participation in a larger cross-sectional PD observational study at our research center. Veterans were recruited primarily from movement disorders neurology clinics at the Ann Arbor Veterans Affairs (VA) Health System. Non-Veterans were recruited primarily from analogous clinics at the University of Michigan Health System. We explored differences in cardiovascular risks factor burden between the groups. Results: Veterans with PD showed higher scores on the simplified Framingham 10-year general cardiovascular disease risk calculator (FR score; 27.3% (11.5) vs. 20.7% (6.8); t = –2.66, p = 0.011) and fewer years of self-reported education (14.5 (2.5) vs. 16.7 (2.6); t = 3.33, p = 0.002). After adjusting for age, disease duration, education, and the use of antihypertensive medications, Veterans showed higher FR scores ( t = 2.95, p = 0.005) and a higher intra-subject ratio of FR score to age-and-gender normalized FR score ( t = 2.49, p = 0.016), representing an elevated component of modifiable cardiovascular risk factor burden. Conclusion: Cardiovascular comorbidities are common in Veterans with PD and may be more severe than in non-Veteran PD populations. These findings merit replication in other representative cohorts. Veterans may be a preferred population for clinical trials evaluating cardiovascular risk factor management on PD progression.
Penser l’échange artistique franco-algérien: la bande dessinée Alger–Marseille: allers-retours de Nawel Louerrad et Benoît Guillaume, et le musée du MuCEM
Authors: Gueydan-Turek Alexandra 
Published: February 2018

(French): Dans la bande dessinée Alger–Marseille:allers-retours, l'artiste algérienne Nawel Louerrad et son homologue français Benoît Guillaume racontent leurs voyages respectifs à Marseille et à Alger. Le fruit d'une commande du Musée des civilisations de l'Europe et de la Méditerranée (MuCEM), ce projet artistique se situe dans le prolongement d'une muséographie renouvelée dont le parti pris serait le décentrement du regard et le relationnel. Dans ce contexte, cet article s'interroge sur la nature des échanges suscités par le projet muséal postcolonial à travers cette bande dessinée. Nous verrons que si les deux récits offrent des visions géo-poétiques et artistiques a priori irréconciliables, l'album dans sa totalité promeut une éthique de l'horizontalité; il se transforme en espace de cohabitation, voire de partage. La résidence croisée des bédéistes et son produit artistique contribuent au final au projet muséal postcolonial du MuCEM en mettant en œuvre une nouvelle dynamique artistico-culturelle entre l'Algérie et la France.
PIC Simulations of Velocity-space Instabilities in a Decreasing Magnetic Field: Viscosity and Thermal Conduction
Authors: Riquelme Mario , Quataert Eliot , Verscharen Daniel 
Published: February 2018

Abstract
We use particle-in-cell (PIC) simulations of a collisionless, electron–ion plasma with a decreasing background magnetic field,

, to study the effect of velocity-space instabilities on the viscous heating and thermal conduction of the plasma. If

decreases, the adiabatic invariance of the magnetic moment gives rise to pressure anisotropies with

(

and

represent the pressure of species j (electron or ion) parallel and perpendicular to
B
). Linear theory indicates that, for sufficiently large anisotropies, different velocity-space instabilities can be triggered. These instabilities in principle have the ability to pitch-angle scatter the particles, limiting the growth of the anisotropies. Our simulations focus on the nonlinear, saturated regime of the instabilities. This is done through the permanent decrease of

by an imposed plasma shear. We show that, in the regime

(

), the saturated ion and electron pressure anisotropies are controlled by the combined effect of the oblique ion firehose and the fast magnetosonic/whistler instabilities. These instabilities grow preferentially on the scale of the ion Larmor radius, and make

(where

). We also quantify the thermal conduction of the plasma by directly calculating the mean free path of electrons,

, along the mean magnetic field, finding that

depends strongly on whether

decreases or increases. Our results can be applied in studies of low-collisionality plasmas such as the solar wind, the intracluster medium, and some accretion disks around black holes.
Scaling of Relativistic Shear Flows with the Bulk Lorentz Factor
Authors: Liang Edison , Fu Wen , Böttcher Markus , Roustazadeh Parisa 
Published: February 2018

Abstract
We compare Particle-in-cell simulation results of relativistic electron–ion shear flows with different bulk Lorentz factors, and discuss their implications for spine-sheath models of blazar versus gamma-ray burst (GRB) jets. Specifically, we find that most properties of the shear boundary layer scale with the bulk Lorentz factor: the lower the Lorentz factor, the thinner the boundary layer, and the weaker the self-generated fields. Similarly, the energized electron spectrum peaks at an energy near the ion drift energy, which increases with bulk Lorentz factor, and the beaming of the accelerated electrons along the shear interface gets narrower with increasing Lorentz factor. This predicts a strong correlation between emitted photon energy, angular beaming, and temporal variability with the bulk Lorentz factor. Observationally, we expect systematic differences between the high-energy emissions of blazars and GRB jets.
Nonlinear Effects in Three-minute Oscillations of the Solar Chromosphere. II. Measurement of Nonlinearity Parameters at Different Atmospheric Levels
Authors: Chae Jongchul , Cho Kyuhyoun , Song Donguk , Litvinenko Yuri E. 
Published: February 2018

Abstract
Recent theoretical studies suggest that the nonlinearity of three-minute velocity oscillations at each atmospheric level can be quantified by the two independent parameters—the steepening parameter and the velocity amplitude parameter. For the first time, we measured these two parameters at different atmospheric levels by analyzing a set of spectral lines formed at different heights of sunspots ranging from the temperature minimum to the transition region. The spectral data were taken by the Fast Imaging Solar Spectrograph of the Goode Solar Telescope, and by the Interface Region Imaging Spectrograph. As a result, from the wavelet power spectra of the velocity oscillations at different heights, we clearly identified the growth of the second harmonic oscillations associated with the steepening of the velocity oscillation, indicating that higher-frequency oscillations of periods of 1.2 to 1.5 minutes originate from the nonlinearity of the three-minute oscillations in the upper chromosphere. We also found that the variation of the measured nonlinearity parameters is consistent with the theoretical expectation that the nonlinearity of the three-minute oscillations increases with height, and shock waves form in the upper chromosphere. There are, however, discrepancies as well between theory and observations, suggesting the need to improve both theory and the measurement technique.
Constraints on the Mass–Richness Relation from the Abundance and Weak Lensing of SDSS Clusters
Authors: Murata Ryoma , Nishimichi Takahiro , Takada Masahiro , Miyatake Hironao , Shirasaki Masato , More Surhud , Takahashi Ryuichi , Osato Ken 
Published: February 2018

Abstract
We constrain the scaling relation between optical richness (λ) and halo mass (M) for a sample of Sloan Digital Sky Survey (SDSS) red-sequence Matched-filter Probabilistic Percolation (redMaPPer) galaxy clusters within the context of the Planck cosmological model. We use a forward modeling approach where we model the probability distribution of optical richness for a given mass,

. To model the abundance and the stacked lensing profiles, we use an emulator specifically built to interpolate the halo mass function and the stacked lensing profile for an arbitrary set of halo mass and redshift, which is calibrated based on a suite of high-resolution N-body simulations. We apply our method to 8312 SDSS redMaPPer clusters with 20 ≤ λ ≤ 100 and 0.10 ≤ z

λ
≤ 0.33 and show that the lognormal distribution model for

, with four free parameters, well reproduces the measured abundances and lensing profiles simultaneously. The constraints are characterized by the mean relation,

, with

and

(68% CL), where the pivot mass scale M
pivot = 3 × 1014
h
−1
M
⊙, and the scatter

with

and

. We find that a large scatter in halo masses is required at the lowest-richness bins (20 ≤ λ ≲ 30) in order to reproduce the measurements. Without such a large scatter, the model prediction for the lensing profiles tends to overestimate the measured amplitudes. This might imply a possible contamination of intrinsically low-richness clusters due to the projection effects. Such a low-mass halo contribution is significantly reduced when applying our method to the sample of 30 ≤ λ ≤ 100.
Interstellar Neutral Helium in the Heliosphere from IBEX Observations. V. Observations in IBEX-Lo ESA Steps 1, 2, and 3
Authors: Swaczyna Paweł , Bzowski Maciej , Kubiak Marzena A. , Sokół Justyna M. , Fuselier Stephen A. , Galli André , Heirtzler David , Kucharek Harald , McComas David J. , Möbius Eberhard , Schwadron Nathan A. , Wurz P. 
Published: February 2018

Abstract
Direct-sampling observations of interstellar neutral (ISN) He by the Interstellar Boundary Explorer (IBEX) provide valuable insight into the physical state of and processes operating in the interstellar medium ahead of the heliosphere. The ISN He atom signals are observed at the four lowest ESA steps of the IBEX-Lo sensor. The observed signal is a mixture of the primary and secondary components of ISN He and H. Previously, only data from one of the ESA steps have been used. Here, we extend the analysis to data collected in the three lowest ESA steps with the strongest ISN He signal, for the observation seasons 2009–2015. The instrument sensitivity is modeled as a linear function of the atom impact speed onto the sensor’s conversion surface separately for each ESA step of the instrument. We find that the sensitivity increases from lower to higher ESA steps, but within each of the ESA steps it is a decreasing function of the atom impact speed. This result may be influenced by the hydrogen contribution, which was not included in the adopted model, but seems to exist in the signal. We conclude that the currently accepted temperature of ISN He and velocity of the Sun through the interstellar medium do not need a revision, and we sketch a plan of further data analysis aiming at investigating ISN H and a better understanding of the population of ISN He originating in the outer heliosheath.
How to develop the full well-being profile among us employees? A person-centered approach
Authors: Biétry Franck , Creusier Jordane 
Published: February 2018

L’objet de cette étude exploratoire est de tester les liens entre les pratiques de GRH de haute performance et la probabilité d’appartenir aux différents profils de bien-être au travail. Plus précisément, il s’agit d’identifier les pratiques de GRH associées au profil le moins corrélé à l’épuisement professionnel et à l’intention de quitter l’organisation. En nous appuyant sur la « treadmill theory » revisitée et le « capital psychologique », nous faisons l’hypothèse générale que les salariés ont de plus fortes chances d’appartenir au profil recherché quand des opportunités d’utiliser leurs compétences dans le contexte organisationnel leur sont offertes et lorsqu’ils y sont incités par des récompenses. Pour tester cette hypothèse, une analyse en profils latents et des régressions logistiques multinomiales ont été réalisées au sein d’un échantillon de 492 salariés nord-américains. Les résultats permettent de conserver cette hypothèse. Ils révèlent l’intérêt de l’approche centrée sur les personnes pour définir une stratégie managériale réaliste de développement pas à pas du profil de bien-être complet.
Hexavalents in spermatocytes of Robertsonian heterozygotes between Mus m. domesticus 2n=26 from the Vulcano and Lipari Islands (Aeolian Archipelago, Italy)
Authors: Berríos Soledad , Fernández-Donoso Raúl , Page Jesús , Ayarza Eliana , Capanna Ernesto , Solano Emanuela , Castiglia Riccardo 
Published: February 2018

The size and shape of the chromosomes, as well as the chromosomal domains that compose them, are determinants in the distribution and interaction between the bivalents within the nucleus of spermatocytes in prophase I of meiosis. Thus the nuclear architecture characteristic of the karyotype of a species can be modified by chromosomal changes such as Rb chromosomes. In this study we analysed the meiotic prophase nuclear organization of the heterozygous spermatocytes from Mus musculus domesticus 2n=26, and the synaptic configuration of the hexavalent formed by the dependent Rb chromosomes Rbs 6.16, 16.10, 10.15, 15.17 and the telocentric chromosomes 6 and 17. Spreads of 88 pachytene spermatocytes from two males were studied and in all of them five metacentric bivalents, four telocentric bivalents, one hexavalent and the XY bivalent were observed. About 48% of the hexavalents formed a chain or a ring of synapsed chromosomes, the latter closed by synapsis between the short arms of telocentric chromosomes 6 and 17. About 52% of hexavalents formed an open chain of 10 synapsed chromosomal arms belonging to 6 chromosomes. In about half of the unsynapsed hexavalents one of the telocentric chromosome short arms appears associated with the X chromosome single axis, which was otherwise normally paired with the Y chromosome. The cluster of pericentromeric heterochromatin mostly determines the hexavalent’s nuclear configuration, dragging the centromeric regions and all the chromosomes towards the nuclear envelope similar to an association of five telocentric bivalents. These reiterated encounters between these chromosomes restrict the interactions with other chromosomal domains and might favour eventual rearrangements within the metacentric, telocentric or hexavalent chromosome subsets. The unsynapsed short arms of telocentric chromosomes frequently bound to the single axis of the X chromosome could further complicate the already complex segregation of hexavalent chromosomes.
Le diagnostic allergique de la brucellose
Authors: Fenster-Bank R. 
Published: February 2018

Un nouvel allergène, la brucelline I.N.R.A., est proposé pour le dépistage de la brucellose par l'épreuve d’hypersensibilité cutanée de type retardé. L’injection de cet allergène, facile et sans danger pour l'animal, ne provoque pas la formation d'anticorps détectables par les épreuves habituelles de dépistage sérologique, ni la sensibilisation de l'organisme. Le dépistage ultérieur, par épreuves allergiques ou sérologiques, n’est donc pas perturbé par une première épreuve.
Le test allergique est proposé pour améliorer le diagnostic de la brucellose chez les bovins et les petits ruminants, et pour éviter des prises de sang fastidieuses, en particulier dans les troupeaux de petits ruminants situés dans des zones réputées indemnes.
Effets de l'adjonction d'huile de maïs à un régime alimentaire pour veaux de boucherie : II. Métabolisme des acides gras polyinsaturés
Authors: Aurousseau Bernard , Bauchart Dominique , Joussellin Wilfrid , Poissonnet P. , Duboisset F. , Legay C. 
Published: February 2018

Lipid metabolism of preruminant calves as affected by 4 levels of linoleic acid intake was studied. Group 1 of calves received a milk diet devoid of emulsifier) which linoleic acid content amounted to 1.22 % gross energy of the milk. Groups 2, 3 and 4 of calves received a milk diet (with soja lecithin as emulsifier) which linoleic acid content amounted to 1,65 % gross energy of the milk ; rations were supplemented daily with 5 ml com oil from the 63th day of trial in the case of the 3rd group of calves or from the 6th day of trial in the case of the 4th group of calves
Plasma, liver, rectus abdominis muscle or perirenal and subcutaneous adipose tissue lipids were analyzed on 6 calves from each group. Linoleic acid proportions increased along with level of intake in most of tissue lipids, except for plasma cholesterol esters or adipose tissue phospholipids at the end of the trial (same proportions in the case of groups 1 and 4).
According to the appearance of C20 : 3 (n-9) in perirenal adipose tissues or muscles phospholipids after 112 days of trial, linoleic acid requirements were not met with any of the regimens after the calves reached 100 kg body weight, but as no (C20 : 3 (n-9) appeared in plasma lipids or subcutaneous adipose tissue of the calves from groups 2 and 3, linoleic acid content of the 2 corresponding regimens were nearer to the requirements than in the case of the others.
Diagnostic de gestation chez la chatte par échographie
Authors: Mailhac Jean-Marie 
Published: February 2018

Le diagnostic de gestation par les moyens habituels : palpation abdominale, radiographie, est tardif chez la chatte. Cette espèce a été choisie afin d’établir un diagnostic échographique d'absence ou de présence de gestation.
La détection des ampoules fœtales par échographie est certaine à partir de la fin de la 3’ semaine de gestation. Les examens ont été répétés à la 4*. à la 5* et à la 6* semaine. Les chattes examinées ont fait l’objet d’une ovario-hystérectomie et les images échographiques ont pu être comparées à la pièce opératoire.
Transfert d’embryons chez les bovins : possibilités présentes et futures
Authors: Jondet Raymond , Rabadeux Y. , Le Guilloux Y. , Vincent F. 
Published: February 2018

Bovine embryo transfer : present and future possibilities.
Cervical collections and transfers of bovine embryos have been carried out since 1978 at U.R.C.E.O. (Brittany). During the year 1981, 919 embryos were collected from 163 out of 231 donor cows treated with PMSG and Pg F2 α (an average of 5.63 embryos per cow ; 3.38 being suitable for transfer). When the required conditions were respected (receptor cows in optimal condition, embryos carefully selected, adequate transfer equipment), the 60-90 day pregnancy rate was about 60 %. With frozen embryos, the pregnancy rate was usually lower. Subsequent fertilization of donor cows was not altered : 53.40 % non return rate after insemination at first œstrus following embryo collection. Future possibilities are evoked (better control of ovarian stimulation, new methods of embryo evaluation, in-vitro maturation of ovocytes, microsurgery on embryos).
Maladie de la hyène chez les bovins : une hypophysite d’origine autoimmune ? Résultats préliminaires d’une étude histologique et immunocytochimique
Authors: Pouplard A. , Constantin André , Espinasse Jacques , Dubois Maurice P. 
Published: February 2018

Histological examinations on the hypophysis of animals suffering from Hyena's disease revealed the existence of a lymphocytic hypophysitis.
This fact, together with the presence of antibodies directed against the cells of the anterior hypophysis in the serum of the same animals, indicates that the disease may be of auto-immune origin.
However, the necessity remains to perform additional epidemiological endocrinological, immunological and immunogenetic studies in order to reveal the cause of Hyena's disease.