bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethics and Mysticism: The Work of Kenneth E. Kirk and Some Other Modern Anglicans
Authors: Shaw Jane 
Published: February 2018

AbstractKenneth E. Kirk is regarded as the person who revived moral theology in the Anglican tradition in the early to mid-twentieth century. This article argues that a renewal of interest in mysticism, led especially by W.R. Inge and Evelyn Underhill in the first two decades of the twentieth century, was influential upon Kirk’s outlook, especially his association of moral theology with ascetic theology (or mystical theology), and linking of personal holiness with ethics. Kirk made prayer – especially contemplative prayer – and worship primary in the education of the soul, the forging of Christian character and therefore the creation of a moral agent.
MUC13 contributes to rewiring of glucose metabolism in pancreatic cancer
Authors: Kumari Sonam , Khan Sheema , Gupta Subash C. , Kashyap Vivek K. , Yallapu Murali M. , Chauhan Subhash C. , Jaggi Meena 
Published: February 2018

AbstractPancreatic tumors are rewired for high-glucose metabolism and typically present with exceptionally poor prognosis. Recently, we have shown that MUC13, which is highly expressed in pancreatic tumors, promotes tumor progression via modulation of HER2 receptor tyrosine kinase activity. Herein, we investigate a novel, MUC13-mediated molecular mechanism responsible for higher glucose metabolism in pancreatic tumors. Our results demonstrate that MUC13 expression leads to the activation/nuclear translocation of NF-κB p65 and phosphorylation of IκB, which in turn upregulates the expression of important proteins (Glut-1, c-Myc, and Bcl-2) that are involved in glucose metabolism. MUC13 functionally interacts and stabilizes Glut-1 to instigate downstream events responsible for higher glucose uptake in pancreatic cancer cells. Altered MUC13 expression by overexpression and knockdown techniques effectively modulated glucose uptake, lactate secretion, and metastatic phenotypes in pancreatic cancer cells. NF-κB inhibitor, Sulfasalazine, abrogates the MUC13 and Glut-1 interaction, and attenuates events associated with MUC13-induced glucose metabolism. Pancreatic ductal adenocarcinoma (PDAC) patient tissue samples also show a positive correlation between the expression of these two proteins. These results delineate how MUC13 rewire aberrant glucose metabolism to enhance aggressiveness of pancreatic cancer and revealed a novel mechanism to develop newer therapeutic strategies for this exceptionally difficult cancer.
Energy harvesting textiles for a rainy day: woven piezoelectrics based on melt-spun PVDF microfibres with a conducting core
Authors: Lund Anja , Rundqvist Karin , Nilsson Erik , Yu Liyang , Hagström Bengt , Müller Christian 
Published: February 2018

AbstractRecent advances in ubiquitous low-power electronics call for the development of light-weight and flexible energy sources. The textile format is highly attractive for unobtrusive harvesting of energy from e.g., biomechanical movements. Here, we report the manufacture and characterisation of fully textile piezoelectric generators that can operate under wet conditions. We use a weaving loom to realise textile bands with yarns of melt-spun piezoelectric microfibres, that consist of a conducting core surrounded by β-phase poly(vinylidene fluoride) (PVDF), in the warp direction. The core-sheath constitution of the piezoelectric microfibres results in a—for electronic textiles—unique architecture. The inner electrode is fully shielded from the outer electrode (made up of conducting yarns that are integrated in the weft direction) which prevents shorting under wet conditions. As a result, and in contrast to other energy harvesting textiles, we are able to demonstrate piezoelectric fabrics that do not only continue to function when in contact with water, but show enhanced performance. The piezoelectric bands generate an output of several volts at strains below one percent. We show that integration into the shoulder strap of a laptop case permits the continuous generation of four microwatts of power during a brisk walk. This promising performance, combined with the fact that our solution uses scalable materials and well-established industrial manufacturing methods, opens up the possibility to develop wearable electronics that are powered by piezoelectric textiles.
Chaihulonggumulitang Shows Psycho-cardiology Therapeutic Effects on Acute Myocardial Infarction by Enhancing Bone Marrow Mesenchymal Stem Cells Mobilization
Authors: Wang Chao , Du Hongsen , Hou Jiqiu , Yan Shasha , Yang Jingjing , Wang Yun , Zhang Xiujing , Zhu Lili , Zhao Haibin 
Published: February 2018

AbstractIschemic myocardium initiates the mobilization and homing of bone marrow mesenchymal stem cells (BM-MSCs) to promote myocardial regeneration after acute myocardial infarction (AMI). Inflammation caused by necrotic cardiomyocytes induce major pathological changes (cardiac remodeling and myocardial apoptosis) as well as anxiety disorder. This process may be inhibited by the differentiation and paracrine effects of BM-MSCs. However, the spontaneous mobilization of BMSCs is insufficient to prevent this effect. Given the anti-inflammatory effects of BM-MSCs, ventricular remodeling and anxiety following AMI, methods focused on enhancing BMSCs mobilization are promising. BFG is a classical traditional Chinese prescription medicine and has been proved effective in treating AMI and reducing anxiety, but the potential mechanism of its function remains unknown. In the present study, we explored the effects of Chaihulonggumulitang (BFG) on AMI and anxiety in vivo and in vitro. We also tested its effects in promoting BMSCs mobilization and alleviating inflammation. Our data showed that the classical Chinese prescription BFG promoted BM-MSCs mobilization, inhibited inflammatory response, and improved heart damage and anxiety developed from AMI. Thus, we provided an underlying mechanism of BFG function in psycho-cardiology conditions such as AMI.
Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT
Authors: Bharate Jaideep B. , McConnell Nicholas , Naresh Gunaganti , Zhang Lingtian , Lakkaniga Naga Rajiv , Ding Lucky , Shah Neil P. , Frett Brendan , Li Hong-yu 
Published: February 2018

AbstractFMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML. A frequent, clinical limitation is FLT3 selectivity, as concomitant inhibition of FLT3 and c-KIT is thought to cause dose-limiting myelosuppression. Through a rational design approach, novel FLT3 inhibitors were synthesized employing a pyridine/pyrimidine warhead. The most potent compound identified from the studies is compound13a, which exhibited an IC50value of 13.9 ± 6.5 nM against the FLT3 kinase with high selectivity over c-KIT. Mechanism of action studies suggested that13ais a Type-II kinase inhibitor, which was also supported through computer aided drug discovery (CADD) efforts. Cell-based assays identified that13awas potent on a variety of FLT3-driven cell lines with clinical relevance. We report herein the discovery and therapeutic evaluation of 4,6-diamino pyrimidine-based Type-II FLT3 inhibitors, which can serve as a FLT3-selective scaffold for further clinical development.
Sunlight-driven eco-friendly smart curtain based on infrared responsive graphene oxide-polymer photoactuators
Authors: Leeladhar  , Raturi Parul , Singh J. P. 
Published: February 2018

AbstractPhotomechanical actuation is the conversion of light energy into mechanical energy through some smart materials. Infrared-responsive smart materials have become an emerging field of research due to easy availability and eco-friendly nature of their stimulus in the form of sunlight, which contains about 50% of near-infrared(nIR) making these materials useful at macro-scale photoactuator applications. Here, we demonstrate fabrication of highly versatile nIR triggered photoactuators based on graphene oxide/polycarbonate bilayers that offers fast, low-cost fabrication, large deflection, reversible actuation and wavelength-selective response. The photoactuators are realized by vacuum filtration of graphene oxide/water dispersion through polycarbonate membrane resulting graphene oxide/polymer bilayer structure. The photoactuation response was measured in the form of deflection from equilibrium position as a result of infrared-irradiation. The deflection is caused by the generated thermal stress at the interface of bilayers due to mismatch of thermal expansion coefficient as a results of nIR absorption by graphene oxide and subsequent temperature rise. A maximum deflection of 12 mm (circular-shaped structure with diameter 28 mm) with corresponding bending curvature of 0.33 cm−1 was shown by this photoactuator for illumination intensity of 106 mW/cm2. Few applications of these photoactuators such as sunlight-driven smart curtain, infrared actuated curtain and self-folding box are also demonstrated
Potential effects of ultraviolet radiation reduction on tundra nitrous oxide and methane fluxes in maritime Antarctica
Authors: Bao Tao , Zhu Renbin , Wang Pei , Ye Wenjuan , Ma Dawei , Xu Hua 
Published: February 2018

AbstractStratospheric ozone has begun to recover in Antarctica since the implementation of the Montreal Protocol. However, the effects of ultraviolet (UV) radiation on tundra greenhouse gas fluxes are rarely reported for Polar Regions. In the present study, tundra N2O and CH4fluxes were measured under the simulated reduction of UV radiation in maritime Antarctica over the last three-year summers. Significantly enhanced N2O and CH4emissions occurred at tundra sites under the simulated reduction of UV radiation. Compared with the ambient normal UV level, a 20% reduction in UV radiation increased tundra emissions by an average of 8 μg N2O m−2h−1and 93 μg CH4m−2h−1, whereas a 50% reduction in UV radiation increased their emissions by an average of 17 μg N2O m−2h−1and 128 μg CH4m−2h−1. No statistically significant correlation (P > 0.05) was found between N2O and CH4fluxes and soil temperature, soil moisture, total carbon, total nitrogen, NO3−-N and NH4+-N contents. Our results confirmed that UV radiation intensity is an important factor affecting tundra N2O and CH4fluxes in maritime Antarctica. Exclusion of the effects of reduced UV radiation might underestimate their budgets in Polar Regions with the recovery of stratospheric ozone.
Geriatrische Dens-Fraktur – Konservative Therapie
Authors: Heyde Christoph-Eckhard 
Published: February 2018

ZusammenfassungDie Therapie geriatrischer Densfrakturen, insbesondere des Typ II nach Anderson und D’Alonzo, wird nach wie vor kontrovers diskutiert. Aktuelle Reviews und erste prospektive Studiendaten legen Vorteile der operativen Versorgung, vor allem in Bezug auf die Mortalitätsrate, nahe.Eine kritische Würdigung der zur Verfügung stehenden Daten der aktuellen Literatur führt jedoch zu Ergebnissen, welche eine vorsichtige Interpretation dieser Daten nahelegen und einen weiterhin hohen Stellenwert der konservativen Therapie aufzeigen.Die Komplikationsrate beider Vorgehensweisen – operativ versus konservativ – ist vergleichbar. Die konservative Therapie ist mit einer höheren Pseudarthroserate verbunden. Allerdings wird das Erreichen einer fibrösen Steife auch als Therapieerfolg angesehen und der klinische Stellenwert der Pseudarthrose verbleibt unklar. Die Datenlage in Bezug auf die Mortalität ist nach wie vor, auch in Reviews und Metaanalysen, inkonsistent. Während bei Patienten zwischen 65 bis 80 – 85 Jahre die Mortalität nach konservativer Versorgung höher zu sein scheint, gibt es Arbeiten, die bei Patienten ab 80 – 85 Jahren eine Aufhebung dieser Unterschiede und in dieser Altersklasse generell Vorteile der konservativen Therapie sehen.Das zentrale Problem der aktuell zur Verfügung stehenden Literatur, auch der vorliegenden prospektiven aber nicht randomisierten Daten besteht in dem Selektionsbias und damit in der fehlenden wirklichen Vergleichbarkeit der analysierten Patientenkohorten.Somit konnte bis zum jetzigen Zeitpunkt keine wirkliche Überlegenheit einer der beiden Therapieformen aufgezeigt werden. Damit hat die konservative Therapie ihren Stellenwert und muss in die therapeutischen Überlegungen gleichberechtigt einbezogen werden.
Pure Ocular Myasthenia gravis
Authors: Kirzinger Lukas , Schötz Sophie , Schalke Berthold 
Published: February 2018

AbstractPure ocular myasthenia was always described as a separate entity in historical publications. More than 50% of patients develop generalized symptoms in the course of the disease. Therefore pure ocular symptoms can be the beginning of generalized myasthenia, nevertheless there is a small group of patients who suffer lifelong purely ocular symptoms. The basis, therefore, seems to be special immunological, biochemical and pathophysiological mechanisms leading to specific local changes of the neuromuscular junction. The diagnostic procedure is hampered as antibodies against acethylcholine receptors and MuSK can be demonstrated in less than 50% of these patients. Therapy of pure ocular myasthenia does not differ fundamentally from other subgroups of myasthenia gravis and is implemented with cholinesterase inhibitors, steroids and common immunosuppressants. Thymomectomy is not recommended in general, but randomized controlled studies are lacking.
Die Aktualisierung der Reha-Therapiestandards der Deutschen Rentenversicherung
Authors: Farin Erik , Wirth Astrid , Quaschning Katharina , Meyer Thorsten , Nowik Daniel , Block Irina , Vogel Heiner , Volke Eva 
Published: February 2018

Zusammenfassung
Ziel Es wird von dem 2013–2015 stattgefundenen Prozess der Aktualisierung der Reha-Therapiestandards (RTS) der Deutschen Rentenversicherung berichtet.
Methodik Mit 4 methodischen Zugängen wurde Evidenz gesucht: a) Durchführung systematischer Literaturrecherchen, b) Expertengruppen, Expertenworkshops und Online-Diskussionsforen zur Einbeziehung der Erfahrungen verschiedener Beteiligter einschließlich Patienten, c) Analyse aktueller KTL-Daten („Klassifikation therapeutischer Leistungen“) zur Erfassung des aktuellen Stands der Erfüllung der RTS, d) konzeptionelle Überlegungen zur Bedeutung aktueller Entwicklungen in der Rehabilitation für die Überarbeitung der RTS.
Ergebnisse Für alle 9 RTS liegen nun aktualisierte Versionen vor. Über die Hälfte aller Therapiemodule der RTS basieren auf wissenschaftlicher Evidenz. Weitere Module basieren auf klinischer Erfahrung zur good clinical practice. Insgesamt betrachtet hat sich die Evidenzlage in den letzten Jahren nicht wesentlich verändert, in einigen Fällen gab es aber Hinweise auf eine verbesserte Evidenzlage.
Schlussfolgerung Die überarbeiteten RTS können zur Sicherstellung einer qualitativ hochwertigen Rehabilitation beitragen. Forschungsbedarf besteht bei der Vertiefung der Evidenzbasierung, insbesondere im Hinblick auf Therapieintensitäten.
Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels
Authors: Buyan Amanda , Sun Delin , Corry Ben 
Published: February 2018

SignificanceVoltage-gated sodium channels are integral in electrical signaling within the human body and are key targets for anesthetics and antiepileptic compounds used in surgeries and the treatment of neurological disorders. We have used molecular simulations to determine where a number of these compounds bind inside the pore of a voltage-gated sodium channel to aid the design of new compounds for treating chronic pain, heart conditions, and epilepsy. We uncover two distinct binding sites inside the pore harnessed by neutral and charged drugs, respectively. This explains why so many anesthetic compounds have both neutral and charged forms: The neutral form more easily enters the pore, but the charged form binds more tightly to effectively block the pore and prevent electrical signaling.
Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions
Authors: Altindis Emrah , Cai Weikang , Sakaguchi Masaji , Zhang Fa , GuoXiao Wang , Liu Fa , De Meyts Pierre , Gelfanov Vasily , Pan Hui , DiMarchi Richard , Kahn C. Ronald 
Published: February 2018

Significance
Although there has been tremendous progress in understanding hormone action and its relationship to human physiology and disease, there has been no comprehensive approach to search the viral genome for the presence of human-like hormones. Here, using a bioinformatics approach, we have identified 16 different human peptide hormones/growth factors, including four insulin/insulin growth factor (IGF)1-like peptides (VILPs) that have homologous sequences in viruses. When these VILPs were chemically synthesized, the resulting peptides could bind to human and murine insulin and IGF1 receptors, stimulate postreceptor signaling, increase glucose uptake, and activate proliferation of cells. Injection of VILPs into mice can significantly lower the blood glucose. Thus, VILPs are members of the insulin superfamily and first characterized viral hormones.
The religious-sublime in music, literature and architecture
Authors: Cifuentes-Aldunate Claudio E. 
Published: February 2018

Abstract
The present article is an attempt to propose the semiotic aspect that produces the ”religious- sublime”. Most of the semiotic
characteristics that we use to represent (and produce) the signifiers of the religious-sublime, nevertheless, share their
mechanisms with other modalities of ”sublimeness”. The sublime will be regarded as the representation (in the sense of staging) of
a perception. I will propose how the subjective perception – in this case of the divinity – is (re)constructed by the subject in a
piece of Spanish Gothic literature, in sacred music and in architecture – the room which houses the subjective perception of
divinity.
Longitudinal changes in physical function and physical activity in older adults
Authors: Metti Andrea L , Best John R , Shaaban C Elizabeth , Ganguli Mary , Rosano Caterina 
Published: February 2018

AbstractBackgroundphysical function (PF) and physical activity (PA) both decline as adults age and have been linked to negative outcomes, including dementia, depression and cardiovascular diseases. Although declines in each are associated with numerous negative outcomes, the longitudinal relationship between these two measures is unclear.Objectiveto examine the dynamic, bidirectional associations between declines in PF and PA.Designprospective cohort.Settingthe Monongahela–Youghiogheny Healthy Aging Team (MYHAT) study.Subjectsabout 1,404 men and women, 76.96 ± 7.2 years, 62.4% female and 95.2% white.Methodsover nine annual assessment cycles, PF was evaluated via the timed Up-and-Go task and PA via a self-reported questionnaire. Piecewise latent growth models examined bidirectional associations between PA and PF to determine whether the initial values (intercept) or early slope (cycles 1–5) (in either PF or PA) predicted later slope (cycles 5–9) (in either PF or PA).Resultsinitial PF significantly predicted early (standardised β= −0.10, P < 0.001) and later (standardised β= −0.09, P = 0.01) PA slopes. Initial PA significantly predicted later (standardised β = −0.09, P = 0.04) but not early PF slope. Associations were independent of baseline memory test scores, baseline cognitive status, later cognitive status and age. Early physical function slope neither predicts later PA slope nor did early PA slope predict later PF slope (both P values >0.10).Conclusionsthe relationship between PF and PA is bidirectional, with PF more consistently predicting declines of PA, both in the short- and long-term. Intervening on PF impairments may improve PA engagement, which could in turn promote PF and translate to beneficial effects on cognitive function, cardiovascular health and mood.
Clinical Trials of Blood Pressure Lowering and Antihypertensive Medication: Is Cognitive Measurement State-of-the-Art?
Authors: Elias Merrill F , Torres Rachael V , Davey Adam 
Published: February 2018

Abstract
Randomized controlled trials of blood pressure (BP) lowering and antihypertensive medication use on cognitive outcomes have often been disappointing, reporting mixed findings and small effect sizes. We evaluate the extent to which cognitive assessment protocols used in these trials approach state-of-the-art. Overall, we find that a primary focus on cognition and the systematic selection of cognitive outcomes across trials take a backseat to other trial goals. Twelve trials investigating change in cognitive functioning were examined and none met criteria for state-of-the-art assessment, including use of at least 4 tests indexing 2 cognitive domains. Four trials investigating incident dementia were also examined. Each trial used state-of-the-art diagnostic criteria to assess dementia, although follow-up periods were relatively short, with only 2 trials lasting for at least 3 years. Weaknesses in each trial may act to obscure or weaken the positive effects of BP lowering on cognitive functioning. Improving trial designs in terms of cognitive outcomes selected and length of follow-up periods employed could lead to more promising findings. We offer logical steps to achieve state-of-the-art assessment protocols, with examples, in hopes of improving future trials.
Aesthetic Improvement of Undeveloped Calves After Treatment of Congenital Clubfoot Deformity
Authors: Andjelkov Katarina , Llull Ramon , Colic Milan , Atanasijevic Tatjana C , Popovic Vesna M , Colic Miodrag 
Published: February 2018

Abstract

Background
Even when clubfoot deformity is treated in a timely manner, the consequences observed in adulthood include hypoplasia of the calf muscles, gait impairment, decreases in foot size, and it can also affect the tibial length. These consequences may have negative impacts on the patient’s subjective appraisal of long-term outcomes, and can influence the patient’s self-esteem in both male and female patients.

Objectives
We present our experience in the treatment of undeveloped calves after surgical treatment of congenital clubfoot.

Methods
In total, 72 patients underwent corrective surgery in order to improve undeveloped calves resulting from a congenital clubfoot deformity. We used calf silicone implants in combination with fat grafting in multistaged procedures, in order to decrease complication rates and improve aesthetic outcome.

Results
Amongst our patients there were 54 (75%) females and 18 (25%) males. All of the patients, except one, had unilateral calf hypoplasia. The procedures were divided into several groups: (1) medial calf augmentation with silicone implants; (2) medial calf augmentation with silicone implants and fat grafting; and (3) medial and lateral calf augmentation with silicone implants and fat grafting. We had one case of a hyperpigmented scar and one case of partial scar dehiscence. There were no cases of compartment syndrome. The average follow-up period was 9.8 months.

Conclusions
Calf enhancement surgery in patients with congenital clubfoot deformity is very gratifying. When combining calf implants with fat grafting in multistaged procedures, we can achieve excellent results with low complication rates.

Level of Evidence: 4