bluuebunny/crossref_metadata_2025_split huggingface dataset:
Change in Drop-Landing Mechanics Over 2 Years in Young Athletes After Anterior Cruciate Ligament Reconstruction
Authors: Ithurburn Matthew P. , Paterno Mark V. , Thomas Staci , Pennell Michael L. , Evans Kevin D. , Magnussen Robert A. , Schmitt Laura C. 
Published: August 2019

Background: While between-limb landing asymmetries after anterior cruciate ligament reconstruction (ACLR) are linked with poor function and risk of additional injury, it is not currently understood how landing symmetry changes over time after ACLR. Purpose/Hypothesis: The purpose was to investigate how double-legged drop vertical jump (DVJ) landing and single-legged drop-landing symmetry changed from the time of return-to-sport (RTS) clearance to 2 years later in a prospective cohort of young athletes after ACLR. It was hypothesized that double-legged DVJ landing and single-legged drop-landing symmetry would improve from the time of RTS to 2 years later. Study Design: Descriptive laboratory study. Methods: The authors followed 64 young athletes with primary, unilateral ACLR for 2 years after RTS clearance. At the time of RTS and 2 years later, between-limb symmetry values for biomechanical variables of interest (VOIs) were calculated with 3-dimensional motion analysis during double-legged DVJ and single-legged drop-landing tasks. VOIs included knee flexion excursion, peak internal knee extension moment, peak vertical ground-reaction force, and peak trunk flexion (for single-legged task only). Symmetry values and proportions of participants meeting 90% symmetry cutoffs were compared between time points. Results: For double-legged DVJ landing, symmetry values for all VOIs and the proportions meeting 90% cutoffs for peak internal knee extension moment and peak vertical ground-reaction force were higher at 2 years after RTS as compared with RTS. For single-legged drop-landing, symmetry values were higher for knee flexion excursion and lower for peak trunk flexion at 2 years after RTS as compared with RTS, but the proportions meeting 90% cutoffs for all VOIs did not differ between time points. Conclusion: Double-legged DVJ landing symmetry improved across VOIs over the 2 years after RTS following ACLR, while single-legged drop-landing did not improve as consistently. The implications of longitudinal landing asymmetry after ACLR should be further studied.
Effectiveness of ecotechnologies for recovery of nitrogen and phosphorus from anaerobic digestate and effectiveness of the recovery products as fertilisers: a systematic review protocol
Authors: Macura Biljana , Johannesdottir Solveig L. , Piniewski Mikołaj , Haddaway Neal R. , Kvarnström Elisabeth 
Published: August 2019

Abstract
Background
The regular addition of plant-available nutrients such as nitrogen and phosphorus, either as manufactured fertilisers or animal manure, to agricultural soils is needed for global food security. Increased recycling of nutrients back to agriculture from organic waste streams is necessary for increased rural–urban sustainability. Anaerobic digestion of sewage sludge and agricultural wastes is widely applied to stabilize the substrate and also capture its energetic value via biogas production. The liquid phase of anaerobic digestate is a concentrated source of nutrients to which nutrient recovery technologies can be applied. Two such promising technologies that could increase nutrient recycling from e.g. wastewater and thereby contribute to environmental amelioration are struvite precipitation and ammonia stripping. By combining anaerobic digestion and nutrient recovery technologies on the digestate, a treatment process that provides both renewable energy and plant nutrients is achieved. This review will examine the effectiveness of ecotechnologies for the recovery and reuse of nitrogen and phosphorus from anaerobic digestate with the aim of reducing the impact of waste on the environment.

Methods
We will search for both academic and grey literature published after 2013. English language searches will be performed in 4 bibliographic databases, and Google Scholar, while searches in 41 specialist websites will be performed in English, Finnish, Polish and Swedish. Eligibility screening will be conducted at two levels: title and abstract and full text. Included eligible studies will be subject to a critical appraisal that will assess external and internal study validity. We will extract information on study characteristics, intervention, comparators, effect modifiers, and measured outcomes. Data synthesis will involve narrative synthesis of each included study of sufficient validity. Quantitative synthesis (i.e. meta-analysis) may be possible in cases where a sufficient number of studies report similar types of outcomes.
Next-Generation Sequencing in 305 Consecutive Patients: Clinical Outcomes and Management Changes
Authors: Davis William , Makar Gabriel , Mehta Pallav , Zhu Gord G. , Somer Robert , Morrison Jamin , Kubicek Gregory J. 
Published: August 2019

PURPOSE: Next-generation sequencing (NGS) is increasingly used to identify actionable mutations for oncology treatment. We examined the results and use of NGS assays at our institution. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 305 consecutive patients who had NGS testing of tumor samples from March 2014 to April 2017. NGS was performed by FoundationOne. RESULTS: Of the 305 tissue samples sent to FoundationOne, 189 reports were potentially usable. Of these reports, 76 (40.21%) demonstrated an aberration targetable by on-label therapies and 126 (66.67%) by off-label therapies, and 170 (89.94%) revealed actionable aberrations via all potential avenues, including clinical trials; 21 of these 189 potentially usable reports (11.1%) yielded a change in management, including use of on-label therapies (n = 7), use of off-label therapies (n = 6), enrollment in a clinical trial (n = 6), and discontinuation of a medication with a predicted poor response (n = 3; one report was used twice). For the six patients with off-label use, median duration of treatment was 46 days and discontinued after death (n = 3) or progression (n = 3). CONCLUSION: Only a minority of NGS assay results (6.9% percent of all tests ordered and 11.1% of useable tests) resulted in a management change. A small minority of patients started off-label therapy on the basis of NSG assay results and overall had poor responses to off-label treatment. Although in theory NGS assays may improve oncologic outcomes, the results of our initial 305 patients showed low clinical utility.
The conserved ancestral signaling pathway from cilium to nucleus
Authors: Satir Peter , Satir Birgit H. 
Published: August 2019

ABSTRACT
Many signaling molecules are localized to both the primary cilium and nucleus. Localization of specific transmembrane receptors and their signaling scaffold molecules in the cilium is necessary for correct physiological function. After a specific signaling event, signaling molecules leave the cilium, usually in the form of an endocytic vesicle scaffold, and move to the nucleus, where they dissociate from the scaffold and enter the nucleus to affect gene expression. This ancient pathway probably arose very early in eukaryotic evolution as the nucleus and cilium co-evolved. Because there are similarities in molecular composition of the nuclear and ciliary pores the entry and exit of proteins in both organelles rely on similar mechanisms. In this Hypothesis, we propose that the pathway is a dynamic universal cilia-based signaling pathway with some variations from protists to man. Everywhere the cilium functions as an important organelle for molecular storage of certain key receptors and selection and concentration of their associated signaling molecules that move from cilium to nucleus. This could also have important implications for human diseases such as Huntington disease.
Randomised study of the effects of neuromuscular electrical stimulation and low-level laser therapy on muscle activation and pain in patients with knee osteoarthritis
Authors: Melo Mônica de Oliveira , Pompeo Klauber Dalcero , Baroni Bruno Manfredini , Sonda Francesca Chaida , Vaz Marco Aurélio 
Published: August 2019

Background The combined effects of low-level laser therapy and neuromuscular electrical stimulation on knee osteoarthritis have yet to be analysed. This study aimed to determine the individual and combined effects of laser therapy and electrical stimulation on muscle activation and pain in older people with knee osteoarthritis. Methods A total of 45 women aged 60–75 years with knee osteoarthritis were randomised into three groups to receive stimulation, laser or stimulation plus laser therapy. All three groups underwent a 4-week control period (without intervention) followed by an 8-week intervention period. The effects of the interventions on muscle inhibition, electrical activity and pain were analysed. Findings There was a decrease in muscle inhibition (effect size ≥0.6) and a reduction in pain (effect size >1.2) in all three groups. All therapies generated an increase in electrical activity (effect size 0.1–0.5). Conclusions Laser alone or in combination with electrical stimulation promoted similar increases in muscle activation and pain relief.
The Assessment of Self-Determination in Spanish and American Adolescents: The Self-Determination Inventory: Student Report
Authors: Shogren Karrie A. , Shaw Leslie A. , Mumbardó-Adam Cristina 
Published: August 2019

Abstract
The purpose of this study was to explore the cross-cultural validity of the Self-Determination Inventory: Student Report, a newly developed measure of self-determination grounded in Causal Agency Theory. The tool was translated to Spanish and administered to American and Spanish adolescents. The sample was structured to include adolescents with and without intellectual disability in both cultural contexts. More than 3,000 students in the U.S. and Spain aged 13 to 22 completed the assessment. Findings suggest that the same set of items can be used across cultural contexts and in youth with and without intellectual disability, although there are some specific differences in item functioning across students with and without intellectual disability in Spain that must be further researched. There were specific patterns of differences in latent self-determination means, with students with intellectual disability scoring lower in the U.S. and Spain. Implications for assessment research and practice in diverse cultural contexts are explored.
Interactions of High School Students With Intellectual and Developmental Disabilities in Inclusive Classrooms
Authors: Chung Yun-Ching , Douglas Karen H. , Walker Virginia L. , Wells Rachel L. 
Published: August 2019

Abstract
As inclusive opportunities increase for students with disabilities, additional research is needed to examine high school students' classroom interactions. This descriptive study explores the nature of the social interactions of 10 high school students with intellectual and developmental disabilities (IDD) in the general education classroom. Findings from our observations indicated that students with IDD interacted with peers during approximately one out of every four minutes and interacted with the general educator during one out of every 10 minutes, less than their peer comparisons' interactions with peers and teachers. Students with IDD were present (M = 89.9%) and in proximity to peers (M = 71.7%) during the majority of the class period. We discuss additional results along with practical implications, limitations, and future research directions.
Circular RNAs in Urine of Kidney Transplant Patients with Acute T Cell-Mediated Allograft Rejection
Authors: Kölling Malte , Haddad George , Wegmann Urs , Kistler Andreas , Bosakova Andrea , Seeger Harald , Hübel Kerstin , Haller Hermann , Mueller Thomas , Wüthrich Rudolf P , Lorenzen Johan M 
Published: August 2019

Abstract

BACKGROUND
Circular RNAs (circRNAs) have recently been described as novel noncoding regulators of gene expression. They are detectable in the blood of patients with acute kidney injury. We tested whether circRNAs were present in urine and could serve as new predictors of outcome in renal transplant patients with acute rejection.

METHODS
A global circRNA expression analysis using RNA from urine of patients with acute T cell-mediated renal allograft rejection and control transplant patients was performed. Dysregulated circRNAs were confirmed in a cohort of 62 patients with acute rejection, 10 patients after successful antirejection therapy, 18 control transplant patients without rejection, and 13 stable transplant patients with urinary tract infection.

RESULTS
A global screen revealed several circRNAs to be altered in urine of patients with acute rejection. Concentrations of 2 circRNAs including hsa_circ_0001334 and hsa_circ_0071475 were significantly increased. These were validated in the whole cohort of patients. hsa_circ_0001334 was upregulated in patients with acute rejection compared with controls. Concentrations of hsa_circ_0001334 normalized in patients with acute rejection following successful antirejection therapy. hsa_circ_0001334 was associated with higher decline in glomerular filtration rate 1 year after transplantation.

CONCLUSIONS
CircRNA concentrations are significantly dysregulated in patients with acute rejection at subclinical time points. Urinary hsa_circ_0001334 is a novel biomarker of acute kidney rejection, identifying patients with acute rejection and predicting loss of kidney function.
Estudo do conhecimento tradicional de pescadores do litoral Sul do Espírito Santo sobre a carcinofauna acompanhante da pesca de camarões
Authors: Braga Adriane Araújo , Zappes Camilah Antunes , Oliveira Ana Carolina Machado de 
Published: August 2019

O presente estudo visa identificar as espécies de crustáceos mais comuns pesca de arrasto segundo o conhecimento de pescadores de três municípios do litoral sul do Estado do Espírito Santo, sudeste do Brasil, e apresentar alguns aspectos relacionados à sua biologia. Entre setembro de 2016 e fevereiro de 2017 foram realizadas observações do cotidiano dos pescadores artesanais e entrevistados 92 pescadores. Todos os entrevistados são do sexo masculino, com idade que varia de 18 a 71 anos, baixa escolaridade e atuam na pesca entre 1 e 41 anos. Em Anchieta, as espécies alvo são os camarões sete-barbas, rosa e branco, enquanto que em Piúma e Marataízes apenas o sete-barbas é alvo da pesca. Nestas comunidades, a carcinofauna acompanhante é composta por siris e caranguejos. Segundo os pescadores, esses crustáceos apresentam semelhanças nos estágios juvenil e adulto, com tais fases ocorrendo no mesmo local. Foi descrita por eles os caracteres de dimorfismo sexual desses organismos. As informações obtidas junto às comunidades tradicionais podem contribuir para a conservação das espécies alvo e da fauna acompanhante, uma vez que o conhecimento etnobiológico é equivalente com a literatura. Este saber local pode ser utilizado em propostas de manejo sustentável bem como na diminuição do impacto sobre as populações das espécies alvo e fauna acompanhante.
Dysbiosis of the Duodenal Mucosal Microbiota Is Associated With Increased Small Intestinal Permeability in Chronic Liver Disease
Authors: Raj Ashok S. , Shanahan Erin R. , Tran Cuong D. , Bhat Purnima , Fletcher Linda M. , Vesey David A. , Morrison Mark , Holtmann Gerald , Macdonald Graeme A. 
Published: August 2019

OBJECTIVES:
Chronic liver disease (CLD) is associated with both alterations of the stool microbiota and increased small intestinal permeability. However, little is known about the role of the small intestinal mucosa-associated microbiota (MAM) in CLD. The aim of this study was to evaluate the relationship between the duodenal MAM and both small intestinal permeability and liver disease severity in CLD.

METHODS:
Subjects with CLD and a disease-free control group undergoing routine endoscopy underwent duodenal biopsy to assess duodenal MAM by 16S rRNA gene sequencing. Small intestinal permeability was assessed by a dual sugar (lactulose: rhamnose) assay. Other assessments included transient elastography, endotoxemia, serum markers of hepatic inflammation, dietary intake, and anthropometric measurements.

RESULTS:
Forty-six subjects (35 with CLD and 11 controls) were assessed. In subjects with CLD, the composition (P = 0.02) and diversity (P < 0.01) of the duodenal MAM differed to controls. Constrained multivariate analysis and linear discriminate effect size showed this was due to Streptococcus-affiliated lineages. Small intestinal permeability was significantly higher in CLD subjects compared to controls. In CLD, there were inverse correlations between microbial diversity and both increased small intestinal permeability (r = −0.41, P = 0.02) and serum alanine aminotransferase (r = −0.35, P = 0.04). Hepatic stiffness was not associated with the MAM.

DISCUSSION:
In CLD, there is dysbiosis of the duodenal MAM and an inverse correlation between microbial diversity and small intestinal permeability.

TRANSLATIONAL IMPACT:
Strategies to ameliorate duodenal MAM dysbiosis may ameliorate intestinal barrier dysfunction and liver injury in CLD.
Modeling of Clinical Phenotypes Assessed at Discrete Study Visits
Authors: Huang Emily , Varadhan Ravi , Carlson Michelle 
Published: August 2019

Abstract
In studies of clinical phenotypes, such as dementia, disability, and frailty, participants are typically assessed at in-person clinic visits. Thus, the precise time of onset for the phenotype is unknown. The discreteness of the clinic visits yields grouped event time data. We investigate how to perform a risk factor analysis in the case of grouped data. Since visits can be months to years apart, numbers of ties can be large, causing the exact tie-handling method of the Cox model to be computationally infeasible. We propose two, new, computationally efficient approximations to the exact method: Laplace approximation and an analytic approximation. Through extensive simulation studies, we compare these new methods to the Prentice-Gloeckler model and the Cox model using Efron’s and Breslow’s tie-handling methods. In addition, we compare the methods in an application to a large cohort study (N = 3,605) on the development of clinical frailty in older adults. In our simulations, the Laplace approximation has low bias in all settings, and the analytic approximation has low bias in settings where the regression coefficient is not large in magnitude. Their corresponding confidence intervals also have approximately the nominal coverage probability. In the data application, the results from the approximations are nearly identical to that of the Prentice-Gloeckler model.
Effect of PWHT Conditions on Toughness and Creep Rupture Strength in Modified 9Cr-1Mo Steel Welds
Authors: Nishikawa Satoru , Hasegawa Tadayuki , Takahashi Makoto 
Published: August 2019

Abstract
We clarified the effect of post weld heat treatment (PWHT) conditions on the toughness and creep rupture strength of modified 9Cr–1Mo steel weldments used for high temperature components of ultra-supercritical power plants. Fracture appearance transition temperature (FATT) decreased as PWHT temperature increased, and for all of the weld metals of tungsten inert gas welding, submerged arc welding and shielded metal arc welding, FATTs were lower than 293 K when the PWHT temperature was higher than 1,008 K. In contrast, in the uniaxial creep test with a loaded stress of 108 MPa, the creep rupture strength of the specimen on which PWHT was carried out for a holding time of 7.2 ks was significantly decreased when the PWHT temperature was more than 1,033 K. Therefore, the appropriate PWHT temperature range to maintain the toughness and creep fracture strength was 1,008 K ≤ T ≤ 1,033 K.
Satire: An explication
Authors: Park-Ozee Dakota 
Published: August 2019

AbstractOver the past two millennia, satire has transformed from a uniquely Greco-Roman theatrical and poetic form into an ambiguous catch-all applied to political and sociocultural commentary, humor, parody, sarcasm and irony. Despite being a subject of study in any number of fields, explications of satire are limited. It is likely for this reason that there are inter- and intra- disciplinary disconnects in theoretical and methodological approach. Given the contemporary proliferation of satirical work, a proper explication of satire will improve text identification, empirical measures, and interdisciplinary collaboration in satirical research. To that end, this paper explicates satire, evaluates contemporary satirical research in the context of this explication, and recommends future research lines to expand the study of a pervasive construct.
Moral judgment of disparagement humor
Authors: Koszałkowska Karolina , Wróbel Monika 
Published: August 2019

AbstractThe aim of the present study was to analyze the link between the five moral codes proposed in the Moral Foundations Theory and moral judgment of disparagement humor. We presented racist, sexist, homophobic, religion-disparaging and neutral jokes to a group of 108 participants, asking them whether they found laughing at a particular joke moral or immoral. Additionally, participants rated the level of amusement and disgust evoked by each joke. We also measured participants’ moral foundations profiles (Care, Fairness, Loyalty, Authority, and Sanctity). The results confirmed that Care and Fairness were significantly linked to moral judgment of racist, sexist and homophobic jokes, whereas Loyalty, Authority and Sanctity were associated with moral judgment of religion-disparaging jokes. Moreover, these relationships were mediated by emotional responses of amusement and disgust (except for racist jokes, for which we observed no mediating role of amusement).
“Hercules the grocer?”: low-key humor in The Twelve Tasks of Asterix
Authors: Williams Hamish 
Published: August 2019

AbstractThe theme of resistance has been a popular topic inAsterixscholarship, whether this resistance is applied to the historical Gauls in their defiance of imperial Rome, to later nationalist or regionalist sentiments in France against invading forces, to any small groups of locals in opposition to foreign or global forces, to a cultural war between France/Europe and America, or to the dominant educational canon of Western history and literature. What is missing in current scholarship onAsterixis a discussion ofhowthese acts of resistance are created and implemented. To that end, this paper identifies ‘low-key’ humor as a seminal means of achieving this resistance inAsterix; this effect involves a ‘lowering’ where figures of the grand or sublime are supplanted, nullified, or defeated by the more restrained figures of the commonplace. The aim of this paper is to identify the typical character of this low-key humor inAsterixthrough analyzing an exemplary version of this humor – in the animated filmThe Twelve Tasks of Asterix(1976). From the perspective of humor studies, this analysis serves as a corrective to a commonly held impression of theAsterix bandes dessinéesas being characterized by more overt or puerile forms of humor. From the perspective ofAsterixscholarship, this study is the first to analyze one of the animated films; far from being an outlier in the oeuvre,The Twelve Tasksboth consolidates and extends the lowering humor ofAsterixby opening up the possibilities of a new medium.
Crystal structure of dimethyl 3,12-dibenzyl-6,10-diphenyl-3,12-diazapentacyclo [6.3.1.02.7.04.11.05.9]-dodecane-7,11-dicarboxylate — acetone (2/1), C40H38N2O2 ⋅ 0.5C3H6O
Authors: Wang Ya-Nan , Wu Yan , Tian Ye 
Published: August 2019

Abstract
C83H82N4O5, monoclinic, P21/c (no. 14), a = 21.705(8) Å, b = 18.455(6) Å, c = 17.774(7) Å, β = 112.216(6)°, V = 6591(4) Å3, Z = 4, R
gt(F) = 0.0647, wR
ref(F
2) = 0.1531, T = 128 K.
The crystal structure of 1,5-dinitro-2,3,4-trichlorobenzene, C6H1Cl3N2O4
Authors: Peilan Wang , Jianlong Wang , Lizhen Chen , Zihao Zhao , Cai Cao 
Published: August 2019

Abstract
C6H1Cl3N2O4, monoclinic, P21/c (no. 14), a = 5.3193(2) Å, b = 11.3307(4) Å, c = 15.1131(5) Å, β = 93.329(1)°, V = 909.35(6) Å3, Z = 4, R
gt(F) = 0.0264, wR
ref(F
2) = 0.1098, T = 100 K.