bluuebunny/crossref_metadata_2025_split huggingface dataset:
Split crest technique: a solution for atrophic anterior maxilla – case report
Authors: Delai Vanessa Marques , Savaris Leonardo Brunet , Furquim Fábio , Camati Paulo Roberto , Sebastiani Aline Monise , Deliberador Tatiana Miranda , Scariot Rafaela , Zielak João César 
Published: July 2018

Introduction: The rehabilitation of atrophic anterior maxilla can be done by different techniques. Among the procedures for bone augmentation, we can use block grafting, guided bone regeneration, and split crest technique (SCT). SCT consists in bone crest osteotomy, followed by manual/mechanical expansion up to the splitting of the buccal plate from the lingual/palatal plate through greenstick fracture. SCT advantage is the possibility of simultaneously installing a dental implant. However, SCT planning should consider the remaining bone width and the the flap type to obtain success. Objective: To report a case of implant-supported rehabilitation of an atrophic anterior maxilla using the split crest technique with insertion of 4 immediate implants, showing the effectiveness of the technique.
Oral health profile of schoolers attended at the Pediatric Dentistry Clinics of the Federal University of Uberlândia
Authors: Oliveira Vinicius Rodrigues de , Ferreira Danielly Cunha Araújo , Castro Alessandra Maia de , Oliveira Fabiana Sodré de 
Published: July 2018

Introduction and Objective: To characterize the socioeconomic profile, the need for dental treatment of children from zero to 12 years of age attended at Pediatric Dentistry Clinics. Material and methods: We evaluated 552 dental records and verified the child’s birth date, frequency of procedures performed according to tooth type and number of appointments. Results: The results showed that 265 (48.01%) children were females and 287 (51.99%) males, witha mean age of 4 years (±7.5). Of the total, 168 (30.43%) were from families with family income of 1 to 2 minimum wages. A total of 279 (50.54%) children were attended in 2009, 123 (22.29%) in 2010, 150 (27.17%) in 2009/2010. There were 3,350 visits, where 1,833 teeth (1,447 deciduous and 386 permanent) were treated. Of the total number of procedures performed (946), 620 were preventive and 1,326 curative procedures. There was a difference between the preventive and curative procedures performed. Conclusion: Itwas concluded that most of the children attended were infants and preschool children, belonging to families with low socioeconomic status and the deciduous dentition received the greater number of curative procedures.
Contraception: Influence on Vaginal Microbiota and Identification of Vaginal Lactobacilli Using MALDI-TOF MS and 16S rDNA Sequencing
Authors: Fosch Sonia E. , Ficoseco Cecilia A. , Marchesi Antonella , Cocucci Silvina , Nader-Macias Maria E. F. , Perazzi Beatriz E. 
Published: July 2018

Background:The vaginal microbiome is influenced by a wide variety of factors, including contraceptive methods.Aim:To evaluate the effect of contraceptive methods on vaginal microbiota and to compare MALDI-TOF MS and 16S rDNA sequencing for lactobacilli identification.Patients and Methods:One hundred and one (101) women consulting for birth control were included in a prospective study. Their vaginal content was sampled and analyzed once before they started using the contraceptive method of their choice, and twice after the initiation of contraception, at three months (94/101 women attended) and at six months (89/101 women attended). The relative frequencies of yeasts and trichomonas were analyzed. MALDI-TOF MS and 16S rDNA sequence analysis were applied for the identification of lactobacilli in their vaginal microbiota. The following contraceptive methods were assessed: Combined Oral Contraceptive Pill (COCP), Condom (CON) and The Rhythm Method (RHYT). McNemar’s statistical test was applied.Results:A statistically significant association between COCP and normal microbiota was observed after three months (p< 0.01) and after six months (p< 0.0001), when the vaginal microbiota was modified. At six months, inflammatory reaction was detected in 3/7 women in the CON group, while 6/7 patients using RHYT showed the same state. Yeast colonization increased with the COCP. Identification of lactobacilli by MALDI-TOF MS analysis compared to 16S rDNA sequencing yielded 92.9% concordant results.Lactobacillus gasseriandL. crispatuswere the predominant species.Conclusion:The pattern of vaginal states was significantly modified. Hormone administration apparently corrected the alterations and retained a normal vaginal state. MALDI-TOF MS has the potential of being an accurate tool for the identification of vaginal lactobacilli speciesL. murinuswas for the first time isolated from the vagina.
Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels
Authors: Vega Rasgado Lourdes A. , Reyes Guillermo Ceballos , Vega Díaz Fernando 
Published: July 2018

Abstract
In an attempt to clarify the controversial role of nitric oxide (NO) in seizures, the effects of NO on brain GABA transaminase (GABA-T) activity and GABA levels were investigated. To this aim, the effects of the substrate (l-arginine) and inhibitors (Nω-nitro-l-arginine methyl ester, 7-nitroindazole) of NO synthase (NOS) on GABA-T activity and GABA levels in vitro and ex vivo were analyzed. In vitro NO diminished GABA-T activity and increased GABA. Ex vivo NO modified GABA-T activity and GABA levels biphasically. Inhibition of endothelial and neuronal NOS (eNOS and nNOS) had opposite effects on GABA-T activity and GABA levels, even during seizures induced by pentylenetetrazole. Different effects of NO on GABA-T activity and on GABA levels, depending on the NOS isoform involved, may explain its contradictory role in seizures, the endothelial NOS acting as an anticonvulsant and the neuronal NOS as a proconvulsant. nNOS inhibitors may represent a new generation of antiepileptics.
Analysis of diclofenac in water samples using in situ derivatization-vortex-assisted liquid-liquid microextraction with gas chromatography-mass spectrometry
Authors: Aydin Senar , Aydin Mehmet Emin , Beduk Fatma , Tekinay Arzu , Kilic Havva 
Published: July 2018

Abstract
A novel micro-extraction technique for a rapid and sensitive analysis of diclofenac (DCF) in water samples has been developed. DCF was derivatized and extracted simultaneously using vortex-assisted liquid-liquid micro-extraction (VALLME) prior to gas chromatography with mass spectrometry detection. The effects of extraction solvent volume, extraction and derivatization time and ionic strength of the sample were studied using 23 factorial experimental design. The optimum extraction conditions were as follows: 200 μL of chloroform, 25 μL of N-methyl-N-trimethylsilyl-trifluoroacetamide (MSTFA) derivatization reagent, vortex extraction and derivatization time 5 min at 3000 rpm. The extraction recovery for different fortification levels was 98 %. Also, the proposed micro-extraction method exhibited results comparable with the solid phase extraction of real water samples. The proposed one-step VALLME and derivatization method is simpler and faster than the conventional extraction and derivatization methods used for the determination of DCF in real water samples.
Enhancement of ketoconazole dissolution rate by the liquisolid technique
Authors: Molaei Mir-Ali , Osouli-Bostanabad Karim , Adibkia Khosro , Shokri Javad , Asnaashari Solmaz , Javadzadeh Yousef 
Published: July 2018

Abstract
The study was conducted to enhance the dissolution rate of ketoconazole (KCZ) (a poorly water-soluble drug) using the liquisolid technique. Microcrystalline cellulose, colloidal silica, PEG400 and polyvinyl pyrrolidone (PVP) were employed as a carrier, coating substance, nonvolatile solvent and additive in the KCZ liquisolid compact formulation, respectively. The drug-to-PEG400 and carrier-to-coating ratio variations, PVP concentration and aging effects on the in vitro release behavior were assessed. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD) data revealed no alterations in the crystalline form of the drug and the KCZ-excipient interactions within the process. The load factor and the drug release rate were significantly enhanced compared to directly compressed tablets in the presence of the additive. Increasing the PEG400-to-drug ratio in liquid medications enhanced the dissolution rate remarkably. The dissolution profile and hardness of liquisolid compacts were not significantly altered by keeping the tablets at 40 °C and relative humidity of 75 % for 6 months. With the proposed modification of the liquisolid process, it is possible to obtain flowable, compactible liquisolid powders of high-dose poorly-water soluble drugs with an enhanced dissolution rate.
Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities
Authors: Gouda Ahmed M. , Abdelazeem Ahmed H. , Abdalla Ashraf N. , Ahmed Muhammad 
Published: July 2018

Abstract
Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives (4a-c and 5a-c) was prepared and evaluated for their anti-inflammatory, analgesic and anticancer activities. The (EZ)-7-cyano-6-((4-hydroxybenzylidene)amino)-N-(p-tolyl)-2,3-dihydro-1H-pyrrolizine-5-carboxamide (4b) and (EZ)-6-((4-chlorobenzylidene)-amino)-7-cyano-N-(p-tolyl)-2,3-dihydro-1H-pyrrolizine-5-carboxamide (5b) bearing the electron donating methyl group showed the highest anti-inflammatory activity while (EZ)-6-((4-chlorobenzylidene)amino)-7-cyano-N-phenyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide (5a) was the most active analgesic agent. Cytotoxicity of the new compounds was evaluated against the MCF-7, A2780 and HT29 cancer cell lines using the MTT assay. Compounds 4b and 5b displayed high anticancer activity with IC
50 in the range of 0.30–0.92 μmol L−1 against the three cell lines, while compound (EZ)-N-(4-chlorophenyl)-7-cyano-6-((4-hydroxybenzylidene)-amino)-2,3-dihydro-1H-pyrrolizine-5-carboxamide (4c) was the most active against MCF-7 cells (IC
50 = 0.08 μmol L−1). Both the anti-inflammatory and anticancer activities of the new compounds were dependent on the type of substituent on the phenyl rings. Substituents with opposite electronic effects on the two phenyl rings are preferable for high cytotoxicity against the MCF-7 and A2780 cells. COX inhibition was suggested as the molecular mechanism of the anti-inflammatory activity of the new compounds while no clear relationship could be observed between COX inhibition and anticancer activity. Compound 5b, the most active against the three cell lines, induced dose-dependent early apoptosis with 0.1–0.2 % necrosis in MCF-7 cells. New compounds showed promising drug-likeness scores while the docking study revealed high binding affinity to COX-2. Taken together, this study highlighted the significant impact of the substituents on the anti-inflammatory and anticancer activity of pyrrolizine-5-carboxamides, which could help in further optimization to discover good leads for the treatment of cancer and inflammation.
In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations
Authors: Zagorchev Plamen Ivanov , Apostolova Elisaveta Georgieva , Pilicheva Bissera Asenova , Draganova-Filipova Milena Nenkova , Kokova Vesela Yulieva , Lukanov Julian Borisov 
Published: July 2018

Abstract
The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity.
Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release
Authors: Mužíková Jitka , Komersová Alena , Lochař Václav , Vildová Lucie , Vošoustová Bára , Bartoš Martin 
Published: July 2018

Abstract
This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis.
Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.
Assessment of the Prevalence of Gastric “Gravel Sign” in Dogs with Acute Gastric Dilatation-Volvulus
Authors: Raul Altuzarra , Rosa Novellas , Yvonne Espada , Elisabet Domínguez 
Published: July 2018

Abstract
Radiological examination of gastric “gravel sign” was retrospectively conducted in 60 dogs presented with acute gastric dilatation-volvulus (GDV) syndrome. Other radiographic findings including loss of peritoneal serosal detail, presence of radiopaque foreign bodies, gastric pneumatosis, splenomegaly, and megaesophagus, were also examined in these patients. “Gravel sign” was detected on the pre-operative radiographs of 17 dogs with acute GDV (28.3%), suggesting that these patients could be suffering from chronic partial gastric obstruction before examination. German Shepherd dogs were significantly over-represented in this group (10/17, 58.8%). Dogs with acute GDV showing “gravel sign” should be carefully investigated for the presence of underlying gastrointestinal processes that might be associated with chronic partial obstruction.
Testing of beveled crimp connections made on a prototype stand
Authors: Wróbel Nikodem , Rejek Michał , Królczyk Grzegorz 
Published: July 2018

Abstract
The purpose of this study is to form and test inseparable tight joints, commonly used in the construction of heat exchangers, by crimping operation on designed prototype stand. Crimped joints are made by tools in form of cones with two types of shapes, each of the designed tools have got identical forming angle. This study uses two types of connecting blocks and plates, differing in diameters of hole and flange. Elaboration contains a case study of joints being made by the stand, which in addition to the crimping operations for some cases were glued or brazed. The article presents the features of the formed joints, by examining them by destructive testing: Micrography, tensile strength test, and non-destructive testing: Leakage test. The examined elements have been made of aluminum 6060, which is well suited to indirect or direct operations of forming joints for all kinds of coolers or condensers. Elaborated tests and studies in this study allowed to state, that joining the connection block to plate with the small diameter, was more energy-consuming than in sample sets with bigger diameter, use of glue increasing the strength of the joints by 20%, significant strength increase can be obtained after mechanical clinching with brazing operation or modification of geometrical shape of the jaws
International Application Model Short-Long Term Between GDP and Consumption : Case Study Indonesia
Authors: Sugiarto Teguh , Madu Ludiro , Subagyo Ahmad , Sugiyanto  , Achmadi  
Published: July 2018

SUMMARY
More recently, significant fluctuations in the Indonesian economy justify the need to pay more attention to this issue. In this case, the main purpose of this research is to know the relationship between two issues related to Indonesian macro economy called consumption and GDP for data period during 1967 until 2014. This study investigates the relationship between GDP variables and Indonesian consumption consumption variables using the test ARDL, cointegration and Granger causality. The result of the research can be concluded that, there is long-run equilibrium relationship between GDP and consumption with long-term ARDL model, 10% change of consumption will produce long-term change of 44% in GDP. It is not surprising that there is no short-run equilibrium relationship between GDP and consumption. 10% of consumption will result in a short-term ARDL model change of 95% in GDP. The variables and consumption of GDP are cointegrated in the long run significantly at lag interval 10, whereas the use of lag interval 1 and 5 is not credited in the long run. Using a cointegration test with lag interval 1, 5 and 10 indicates significant for all usage slowness. So it can be summarized in the context of GDP and coordinated short-term economic consumption for all the prevailing interval lags. concluded that long-term causality test results between GDP variables and significant consumption with time intervals 5 and 10. intervals 1, 15 and 20 have no long-term causality relationship between GDP variables and consumption variables. a short-term causal model. With lagging intervals of 1, 5, 10 and 15, there is a short-term causal relationship between the variable GDP and consumption. As for the use of delay interval 20 there is no causal relationship in the short term between the variable GDP and consumption in Indonesia.
Innovative Approach to Measuring the Impact of FDI on Some Macroeconomic Indicators in B&H
Authors: Subotić Slobodan , Erceg Živko , Marković Vladimir , Mitrović Goran 
Published: July 2018

SUMMARY
The necessity of economic life and economic development of every economy is the free movement of capital. The international movement of capital has its balance of payment when capital export represents economic surplus in relation to consumption of the national economy and the import of capital represents an increase of consumption in regard to the output of a national economy. Analysis of the influence of foreign direct investment (FDI) on economic growth of the host country, among other things, is emphasized in the function of the achieved phase of its economic development. Taking all this into consideration, the aim of this paper refers to an attempt to indicate the significance and the role of FDI as well as the importance of attracting foreign direct investment in B&H and the determination of the effects of FDI on the economy of B&H. In this regard, we will try to determine the level of FDI’s impact on some macroeconomic indicators in B&H (GDP, import, export, unemployment) by using contemporary SPSS statistical analysis program (model) and applying the methods (calculating coefficients) of correlation and regression analysis. In other words, we will determine the analytical expression used to describe a statistical relationship of these macroeconomic categories.
Technological relatedness, knowledge space and smart specialisation: The case of Germany
Authors: Vlčková Jana , Kaspříková Nikola , Vlčková Markéta 
Published: July 2018

Abstract
The level of technological specialisation in the regions of Germany is assessed in this paper, as well as how such specialisation has evolved over time. Further, in three selected regions (Munich, Düsseldorf and Oberes Elbtal/Osterzgebirge), the knowledge space is explored in detail and compared to existing smart specialisation strategies. Average relatedness and knowledge space based upon EPO patent applications are used to measure the specialisation and technology trajectories of the German regions. Between three periods 1988–1992, 1998–2002 and 2008–2012, the specialisation of Germany based on EPO patent applications increased by 10%, despite a decline in many regions. Machinery and transportation industries have increased their significance. The assessment of regional smart specialisation strategies in the three German states shows that the methodology in terms of the identification of prospective industries is largely variegated and insufficiently developed. More attention should also be given to the choice of an appropriate geographical level of aggregation for analysis. Knowledge relatedness and knowledge complexity could be used as methodological tools for selecting prospective industries in smart specialisation strategies.
Trends in Inclusive Education in the USA and Canada
Authors: Grynova Maryna , Kalinichenko Iryna 
Published: July 2018

Abstract
This paper deals with foreign experience of implementing inclusive education for children with special educational needs in the United States and Canada. Legal documents on inclusive education in foreign countries have been analyzed. The most relevant topic of American and Canadian scholars’ researches on reforming special education is related to integration, that is gradual transition from exclusion of children with special educational needs to inclusion in comprehensive schools. Based on the analysis of American and Canadian researches on inclusive education it has been concluded that the changes in legislation and education policies of North American countries aim to achieve the highest level of progress in regular education and special education. It has been found that the development of inclusive education in Canada has undergone and is significantly influenced by the American education system. However, unlike the United States, Canada does not have a single legislative act that would standardize the introduction of inclusive education in the country. Each province has autonomous educational documents that specify the requirements for the inclusive education organization. It has been specified that in American schools, effective educational technology in inclusive education is a team approach when effective partner relationships are formed. A key to the successful integration of a child with special educational needs is the development of an individual curriculum. The Canadian education system, having its own national peculiarities that predetermine the differences in the course of education reforms, has always supported the democratic movement for civil rights and anti-discriminatory attitudes in US education. Foreign law and inclusive practice are an important source of ideas about possible ways to solve the problems of implementing inclusive education in Ukraine.