bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do foster youth face harsher juvenile justice outcomes? Reinvestigating child welfare bias in juvenile justice processing
Authors: Goldstein Ezra G. , Font Sarah A. , Kennedy Reeve S. , Connell Christian M. , Kurpiel Allison E. 
Published: November 2024

AbstractResearch summaryFor decades, child welfare scholars and policy makers have been concerned with the strong association between foster care and juvenile justice involvement. Foster care placement may lead to differences in justice system outcomes if youth in foster care face “processing bias”—differentially harsh treatment by agents of the juvenile court. Previous research found that youth in foster care at the time of juvenile justice contact were treated more harshly by the court, resulting in higher rates of punitive case outcomes. We revisit the question of processing bias using detailed administrative data on more than 10,000 adolescents in Pennsylvania in 2015–2019 and a selection‐on‐observables design. We find no evidence of processing bias against youth in foster care. Compared to observationally equivalent cases, those that involve youth in foster care do not experience more punitive outcomes. If anything, our estimates suggest the opposite—youth in foster care are less likely to have a charge adjudicated, be placed under court‐ordered supervision, or enter into juvenile detention. The precision of our estimates and bounding exercises allow us to rule out even modest evidence of punitive processing bias.Policy implicationsThis paper highlights the importance of revisiting the evidence of processing bias within juvenile justice and child welfare agencies. Given the decentralized and continuously evolving nature of these systems, local jurisdictions should investigate their own case outcomes and contexts before implementing reforms to address bias. Yet, many lack the resources for such research and federal support is essential to enhance local data analysis capabilities, promoting more tailored and effective policy reforms. Initiatives that aim to integrate data from multiple systems can better understand and address the needs of overlapping populations, ultimately improving the quality of services and outcomes.
PHACEing a challenging diagnosis: Should we expand the phenotype?
Authors: Goergen Stacy K , Wong LuFee , Fahey Michael C 
Published: November 2024

SummaryPHACE syndrome is a challenging but important prenatal diagnosis due to its protean clinical consequences. The ‘tilted telephone receiver’ sign (TTRS), consisting of asymmetric cerebellar volume reduction and marked counterclockwise, Dandy–Walker‐like upward vermis rotation on prenatal MRI and ultrasound has high specificity for PHACE. Recently, a case report of the prenatal imaging findings in an infant with PHACE described more mild upward vermis rotation and cerebellar clefting. It recommended consideration of expansion of the currently accepted phenotype to improve prenatal detection of the condition. We describe a case with imaging features essentially indistinguishable from the recently published case of PHACE with mild upward vermis rotation, asymmetric cerebellar hemispheric volume loss and a cerebellar hemispheric cleft. Our patient did not have PHACE postnatally at 1 year of follow up. Neurodevelopmental testing in infancy demonstrated mildly atypical development. Fetuses with asymmetric cerebellar hemispheric volume loss, a cleft in the smaller hemisphere and only mild upward vermis rotation, consistent with the proposed ‘expanded PHACE phenotype’ do not always have PHACE. Erroneously adverse prenatal prognostic counselling may result from such prenatal phenotypic expansion.
Microglia‐derived Galectin‐9 drives amyloid‐β pathology in Alzheimer's disease
Authors: Zhang Guoxin , Peng Qinyu , Guo Xiaodi , Pan Lina , Xiong Min , Zhang Xingyu , Dai Lijun , Zhang Zhaohui , Xiao Tingting , He Juanfeng , Liu Miao , Ke Wei , Zhang Zhentao 
Published: November 2024

AbstractThe accumulation of amyloid‐β (Aβ) and overactivation of microglia contribute to the pathogenesis of Alzheimer's disease (AD), but the interaction between microglial activation and Aβ deposition in AD remains elusive. Here we revealed that Aβ activates microglia and promotes the release of Galectin‐9 (Gal‐9), a member of the β‐galactoside–binding family of lectins. The levels of Gal‐9 in the cerebrospinal fluid and brain tissues of AD patients are higher than those in control subjects. Gal‐9 interacts with Aβ and promotes its aggregation, generating Gal‐9‐Aβ fibrils with enhanced seeding activity and neurotoxicity. The expression of Gal‐9 increases with age in the brains of APP/PS1 transgenic mice. Knockout of Gal‐9 in APP/PS1 mice substantially reduced Aβ sedimentation, neuroinflammation, and cognitive impairment. Moreover, depletion of Gal‐9 inhibited the seeding activity of brain homogenates from APP/PS1 mice. These findings reveal a mechanism by which microglia‐derived Gal‐9 accelerates Aβ aggregation and seeding in AD. Thus, strategies aimed at inhibiting Gal‐9 may hold promise as a disease‐modifying therapy to alleviate AD pathology.
Exploring the importance of predicted camel NRAP exon 4 for environmental adaptation using a mouse model
Authors: Lee Sung‐Yeon , Lee Bo‐Young , Lim Byeonghwi , Uzzaman Rasel , Jang Goo , Kim Kwan‐Suk 
Published: October 2024

AbstractCamels possess exceptional adaptability, allowing them to withstand extreme temperatures in desert environments. They conserve water by reducing their metabolic rate and regulating body temperature. The heart of the camel plays a crucial role in this adaptation, with specific genes expressed in cardiac tissue that are essential for mammalian adaptation, regulating cardiac function and responding to environmental stressors. One such gene, nebulin‐related‐anchoring protein (NRAP), is involved in the assembly of myofibrils and the transmission of force within the heart. In our study of the NRAP gene across various livestock species, including three camel species, we identified a camel‐specific exon region in the NRAP transcripts. This additional exon (exon 4) contains an open reading frame predicted in camels. To investigate its function, we generated knock‐in mice expressing camel NRAP exon 4. These ‘camelized mice’ exhibited normal phenotypic characteristics compared with wild‐type mice but showed elevated body temperatures under cold stress. Transcriptome analyses of the hearts from camelized mice under cold stress revealed differentially expressed inflammatory cytokine genes, known to influence cardiac function by modulating the contractility of cardiac muscle cells. We propose further investigations utilizing these camelized mice to explore these findings in greater depth.
Healthcare, school and daily life experiences of patients with microphthalmia or anophthalmia and their parents
Authors: Chireh Evin , Nordquist Jonas , Grönlund Marita Andersson , Fahnehjelm Kristina Teär 
Published: November 2024

AbstractAimThis qualitative study explored the lived experiences of the patients with microphthalmia and anophthalmia and their parents, focusing on the healthcare, school settings and daily life challenges to improve patient management.MethodsIn‐depth interviews were conducted in Stockholm, Sweden, from October 2022 to June 2023. Participants were recruited through the St Erik Eye Hospital database (2008–2022), and the data was analysed using reflexive thematic analysis.ResultsThe study included 15 patients (9 female and 6 male), with a median age of 21 years (range 15–31), and 1 parent per patient. Five key themes were identified from the parental interviews and three from the patient interviews. Both groups emphasised the need for improvements in healthcare, including better physician continuity, emotional support, information provision and prosthesis functionality. Families of those with severe bilateral visual impairment highlighted the need for additional school and daily life support. While some parents had future concerns, most patients viewed their condition as a natural part of life.ConclusionPatients and parents shared insights on the psychosocial impact and suggested improvements in the healthcare and school settings, providing valuable guidance for enhancing care and management for this patient group.
Reduction of Noise Levels During Caesarean Births Through Audiovisual Feedback is Associated With Lower Stress Levels for Patients
Authors: Gabrysch Caroline Helena , Anders Sophie‐Isabelle , Dressler‐Steinbach Iris , Braun Thorsten , Efe Ilhamiyya , Henrich Wolfgang 
Published: November 2024

ABSTRACTObjectiveNoise reduction during surgical procedures leads to improved surgical performance and results. The caesarean birth (CB) is an exceptional operation and a life changing experience. Through the introduction of staff education and implementation of audiovisual feedback, we intended to reduce noise, and subsequently reduce surgical complications and increase the well‐being of patients and staff.MethodsDuring Phase I, blinded baseline measurements of noise were conducted. Phase II started after staff education and structured questionnaires on subjective noise and stress were added, and in Phase III audiovisual feedback was introduced. Mean and peak noise levels over the time of the procedure were obtained in A‐weighted decibels (dB(A)). Kruskal–Wallis H tests were performed to evaluate the impact of interventions on noise levels. Questionnaires were evaluated using descriptive statistics; stress‐scores were compared using independent sample t‐tests.ResultsNinety planned CBs were included. Median noise levels were 62.85 dB(A) at baseline. They decreased significantly to 60.60 dB(A) (Phase II) and 59.25 dB(A) (Phase III), respectively. This reduction of 3.6 dB(A) leads to a subjective noise reduction of around 20%. Significant differences for A‐weighted and peak noise levels during actual surgery were found after combining staff education with audiovisual feedback. In Phase III, staff reported less stressful noise. Stress also decreased significantly in the patient group. Beeping machines and telephones were identified as the most stressful sources of noise.ConclusionWe show that noise reduction during CB is both necessary and possible. Diminished subjective perception of noise and stress are positive impacts of this intervention. Staff education and audiovisual feedback can help to provide a calm and lower stress environment for patients and staff during caesarean births.
Noncanonical TCA cycle fosters canonical TCA cycle and mitochondrial integrity in acute myeloid leukemia
Authors: Watanabe Atsushi , Tipgomut Chartsiam , Totani Haruhito , Yoshimura Kentaro , Iwano Tomohiko , Bashiri Hamed , Chua Lee Hui , Yang Chong , Suda Toshio 
Published: October 2024

AbstractCancer cells rely on mitochondrial oxidative phosphorylation (OXPHOS) and the noncanonical tricarboxylic acid (TCA) cycle. In this paper, we shed light on the vital role played by the noncanonical TCA cycle in a host‐side concession to mitochondria, especially in highly energy‐demanding malignant tumor cells. Inhibition of ATP‐citrate lyase (ACLY), a key enzyme in the noncanonical TCA cycle, induced apoptosis by increasing reactive oxygen species levels and DNA damage while reducing mitochondrial membrane potential. The mitochondrial membrane citrate transporter inhibitor, CTPI2, synergistically enhanced these effects. ACLY inhibition reduced cytosolic citrate levels and CTPI2 lowered ACLY activity, suggesting that the noncanonical TCA cycle is sustained by a positive feedback mechanism. These inhibitions impaired ATP production, particularly through OXPHOS. Metabolomic analysis of mitochondrial and cytosolic fractions revealed reduced levels of glutathione pathway‐related and TCA cycle‐related metabolite, except fumarate, in mitochondria following noncanonical TCA cycle inhibition. Despite the efficient energy supply to the cell by mitochondria, this symbiosis poses challenges related to reactive oxygen species and mitochondrial maintenance. In conclusion, the noncanonical TCA cycle is indispensable for the canonical TCA cycle and mitochondrial integrity, contributing to mitochondrial domestication.
A Blended Learning Course to Support Innovative Online Teaching in Higher Education
Authors: Lazarinis Fotis , Panagiotakopoulos Theodor , Armakolas Stefanos , Vonitsanos Gerasimos , Iatrellis Omiros , Kameas Achilles 
Published: November 2024

ABSTRACTThis paper addresses the challenge of improving the effectiveness and innovativeness of online teaching in higher education. It presents a blended learning course designed for faculty development and discusses the findings of surveying the opinions of participants. The course integrates synchronous sessions with digital learning tools and platforms to equip educators with essential skills for online teaching. A mixed‐methods design has been applied for evaluating the educational activity, incorporating both qualitative and quantitative data collection. The course had a completion rate of 91.13%. The opinions of 72 higher education members have been surveyed, and the findings revealed that the blended learning course enhanced instructors' ability to design and deliver online content that is both pedagogically sound and engaging. The necessity for such learning activities is strongly emphasised. The paper concludes by discussing the implications for future course design and faculty development programs in higher education.
Latent Profiles of Passion and Categories of University Students' Passionate Activities: Difficulties in the Empirical Systematisation of Passion
Authors: Oszwa Urszula , Buczak Agnieszka 
Published: November 2024

ABSTRACTBoth classical and contemporary definitions of education emphasise the development of learners and the discovery of their potential. The period of systemic education at all stages is an opportunity to seek this potential both at school and outside it. These are the circumstances of the development of abilities, interests and passions. In the educational process and in the modern world, the most valued are people who are creative, entrepreneurial, open to new experiences and have a passion—since it provides energy, gives wings, is a source of a sense of freedom and meaning and helps maintain well‐being. This study aimed to explore passion profiles, considering their dimensions and categories, and the respondents' field of study and gender, in a sample of Polish university students (n = 2720). The online Self‐Report Passion Inventory (SRPI) was used. Cluster analysis identified three latent profiles, differentiated by the perceived benefits of passion, its origin and its balance with other life activities. In addition, we identified categories of passionate activities typical of each profile. Field of study and gender were represented in similar ways in the distinguished profiles, indicating the universal nature of passion. The qualitative analysis of the results revealed potential reasons for the difficulties respondents experienced while categorising passionate activities.
Benchmarking Anomaly Detection Methods: Insights From the UCR Time Series Anomaly Archive
Authors: Baldán Francisco J. , García‐Gil Diego 
Published: October 2024

ABSTRACTAnomaly detection, vital for identifying deviations from normative data patterns, is particularly crucial in sensor‐driven real‐world applications, which predominantly involve temporal data in the form of time series. Traditional evaluation of anomaly detection methods has relied on public benchmark datasets. Yet, recent revelations have uncovered inherent flaws and inadequacies in these datasets, casting doubt on the perceived progress in the field. To address this challenge, the UCR Time Series Anomaly Archive has been recently proposed—a meticulously curated database comprising 250 time series—designed to provide a robust and error‐free benchmark for anomaly detection research. This paper comprehensively evaluates state‐of‐the‐art anomaly detection techniques using the UCR Time Series Anomaly Archive. Our findings demonstrate the efficacy of current methods in accurately detecting anomalies across an important portion of datasets without additional optimization, underscoring the archive's utility as a foundational baseline for future research and development in anomaly detection methodologies.
Statistical Lifetime of Composites Subjected to Random and Ordered Block Loadings
Authors: D'Amore Alberto , Grassia Luigi 
Published: October 2024

ABSTRACTThis study presents a procedure based on constant amplitude (CA) fatigue data to predict the statistical fatigue lifetime of glass/orthopolyester composites subjected to repeated ordered and random two, three, and six sequences of block loadings. A numerical routine was developed to detect cycle‐by‐cycle the statistical strength degradation progression until failure, assuming that the strength at the end of a block cycle equals the strength at the start of the successive one and that the individual samples' static strength, the amount of degraded strength, and fatigue life share the same rank in their respective cumulative distribution function. Predictions conform to the statistically undetectable loading sequence effects and lightly overestimate the lifetimes of random and ordered high‐to‐low (1/100 cycles) repeated two‐block loadings. The vanishing effect of the loading sequence when the block extents remain fixed, the block extent effects for a given three‐block sequence, and the lifetimes of three‐block loadings were fully predicted. The six‐block sequence's experimental lifetimes with different block loading orders and block extent fell within the predicted lifetimes' cumulative distribution function. A reliable damage rule based on residual strength was proposed and compared to the Miner's rule.
Serving Innovation: Exploring Patent Agency Service Networks in China
Authors: Wang Junsong , Qi Jie , Pan Fenghua , Liu Zhiqing 
Published: November 2024

ABSTRACTPatent agency services are crucial for the codification of technical knowledge and inventions. Drawing on an inter‐firm network analysis of the patent agency service relationships between patent agencies and their innovation clients during the last two decades in China, this paper seeks to explore the structure of urban patent agency service networks and how it is shaped by China's unique institutional and market forces. The study found that although the patent agency service network generally follows the basic structure of China's innovative and economic landscapes, it is still deeply shaped by China's unique intellectual property institutions, administrative hierarchy factors, market forces driven by patent agency service demand, and multidimensional proximities in a complex manner. Analyzing how these factors function should be related to the characteristics of patent agencies and the actors of networks. The study will help us understand how city patent service networks might be shaped by institutional and spatial factors, and provide new evidence on how cities are interlinked within patent agency service networks.
Developing STEP‐SE: A Qualitative Usability Study of a Novel Patient‐Reported Outcomes Tool for Managing Side Effects in Shared Decision‐Making for Schizophrenia Spectrum Disorder Care
Authors: Rodolico Alessandro , Di Francesco Antonio , Cutrufelli Pierfelice , Bighelli Irene , Caponnetto Pasquale , Concerto Carmen , Conti Davide , Furnari Rosaria , Leotta Gabriele , Mineo Ludovico , Messina Antonino , Müller Katharina , Petralia Antonino , Quattropani Maria Catena , Siafis Spyridon , Leucht Stefan , Signorelli Maria Salvina 
Published: November 2024

ABSTRACTBackgroundSchizophrenia treatment with antipsychotics often results in side effects that impact adherence and quality of life. Managing these effects remains challenging, as it requires balancing efficacy and tolerability. The Schizophrenia Technological Evaluation of Patient Side Effects (STEP‐SE) app aims to aid side effects monitoring and management through shared decision‐making (SDM).AimThis study aimed to evaluate the usability of the STEP‐SE app for patients and clinicians in managing antipsychotic side effects.MethodsSixteen stable outpatients and 14 psychiatrists participated in semi‐structured interviews after using the STEP‐SE app. Questions explored ease of use, information clarity, user needs fulfilment, patient–clinician collaboration, treatment adherence improvement, patient empowerment and clinical utility. Data were analysed thematically.ResultsOverall satisfaction with STEP‐SE was high. Both groups found that the tool improved patient involvement, provided reliable information to enhance therapeutic alliance, posed low risks of misunderstanding and had an intuitive interface. Patients felt more motivated and empowered. Clinicians appreciated guideline consistency. Preferences differed regarding data visualization formats.DiscussionSTEP‐SE shows potential for aiding SDM on antipsychotic side effects. Patients gained motivation, and clinicians felt reassured. Refinements around mobile access, graphics and features could augment utility. Generalizability is limited given the stable patient sample.ConclusionPreliminary findings suggest that STEP‐SE effectively engages patients, empowers them and supports clinicians in collaborative side effect management. Further testing with diverse user groups is warranted.Patient or Public ContributionThe current study was designed to gather patient and public feedback for the development of our decision aid tool, STEP‐SE. Participants interacted with the tool's prototype in interactive sessions, providing insights and identifying technical issues. Their feedback was crucial for enhancing the tool, with each suggestion and bug report carefully considered for future iterations. The participants’ contributions were key in optimizing STEP‐SE's features and ensuring its relevance and reliability. We thank all who shared their time and perspectives, significantly shaping the tool's user‐centred design.
Mental Health Experiences Among Undergraduate Nursing Students in a New Zealand Tertiary Institution: A Time for Change
Authors: Solomon Bernadette , Topp Maia , Solomon David J. A. , Solomon David 
Published: November 2024

ABSTRACTNursing students in undergraduate programmes exhibit comparable, sometimes higher, levels of poor mental health and substance use compared to the general population; however, this area remains under‐researched in New Zealand. The study involved 172 nursing students enrolled in the Bachelor of Nursing programme at one tertiary institution in Auckland, New Zealand. Employing a mixed‐methodology approach, a 29‐question survey comprising both open and closed questions was administered to explore the students' experiences with mental health and substance use, as well as their access to support services. Quantitative data were analysed using SPSS version 29 descriptive statistics, while a general inductive approach guided the qualitative analysis. A significant proportion of participants (75%) reported experiencing emotional distress during their studies, with anxiety being the most prevalent (78.5%). A smaller percentage disclosed substance use (8.1%) including excessive alcohol use, cannabis use, nicotine use, vaping cannabis and some refusal to reveal substance use. Surprisingly, less than 1% (n = 0.6) utilised institutional support services. Three qualitative themes were identified including emotional distress and associated effects, emotional and psychological impacts on nursing students' academic journey and tertiary support systems. The findings highlight the urgent need to address the mental health and addiction challenges experienced by nursing students, given their potential adverse effects on academic success and overall well‐being. Urgent action is needed to integrate mental health training into the curriculum and provide faculty support. In this study, the underutilisation and inadequacy of institutional support services signal a need for institutional reforms to provide access and personalised mental health support to nursing students. Providing essential skills and support for student success contributes to the overall well‐being of the nursing workforce.