bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soil surface complexity has a larger effect on food exploitation by ants than a change from grassland to shrubland
Authors: RADNAN GABRIELLA N. , GIBB HELOISE , ELDRIDGE DAVID J. 
Published: February 2018

1. Changes in vegetation community composition, such as a transition from grassland to shrubland (woody encroachment), are associated with reductions in plant cover and increases in bare ground. Encroachment‐driven changes in surface cover at small spatial scales can alter ant community assemblages by changing their foraging behaviour and their ability to locate and monopolise resources.2. Artificial arenas with three levels of complexity were used to examine changes in ant foraging efficiency, body size and ability to monopolise food. The three levels of complexity included a control (no substrate), low‐complexity treatment (woody debris) and high‐complexity treatment (leaf litter).3. No difference was found in ant species composition within the complexity arenas between grassland and shrubland, but ant functional groups ‘generalised Myrmicinae’ and ‘subordinate Camponotini’ were more abundant in grassland arenas, whereas ‘opportunists’ were more abundant in shrubland arenas. Ants took twice as long to find baits in high‐complexity treatments, and 1.5 times as long in low‐complexity treatments, than in control treatments, which were bare arenas with no substrate. Ant body size declined with increasing surface complexity, suggesting that larger ants are discouraged from foraging in complex habitats.4. There was also significantly greater monopolisation of the protein bait (tuna) in low‐ and high‐complexity treatments, but there were no differences between tuna and carbohydrate (honey) in the control treatment. Consistently, no differences were found in ant behaviour between grasslands and shrublands.5. The present study shows that ants are more responsive to small‐scale alterations in soil surface complexity than to changes in vegetation community composition. Changes in soil surface complexity select for ants based on body size, which in turn influences their foraging success. Changes in vegetation complexity at small spatial scales are therefore likely to influence ant behaviour and abundance of some functional groups, potentially having an effect on the many ecosystem functions carried out by ants.
Class structure and inequality during the industrial revolution: lessons from England's social tables, 1688–1867
Authors: Allen Robert C. 
Published: February 2018

AbstractThis article measures the size and incomes of six major social classes across the industrial revolution using social tables for England and Wales in 1688, 1759, 1798, 1846, and 1867. Lindert and Williamson famously revised these tables, and this article extends their work in three directions. First, servants are removed from middle‐ and upper‐class households in the tables of King, Massie, and Colquhoun and tallied separately. Second, estimates are made for the same tables of the number and incomes of women and children employed in the various occupations, and, third, incomes are broken down into rents, profits, and employment income. These extensions to the tables allow variables to be computed that can be checked against independent estimates as a validation exercise. The tables are retabulated in a standardized set of six social groups to highlight the changing structure of society across the industrial revolution. Gini coefficients are computed from the social tables to measure inequality. These measures confirm that Britain traversed a ‘Kuznets curve’ in this period. Changes in overall inequality are related to the changing fortunes of the major social classes.
Rituximab, cladribine, and cyclophosphamide (RCC) induction with rituximab maintenance in chronic lymphocytic leukemia: PALG ‐ CLL4 (ML21283) trial
Authors: Robak Tadeusz , Błoński Jerzy , Skotnicki Aleksander Bartłomiej , Piotrowska Magdalena , Wróbel Tomasz , Rybka Justyna , Kłoczko Janusz , Bołkun Łukasz , Budziszewska Bożena Katarzyna , Walczak Urszula , Uss Anatoly , Fidecka Marta , Smolewski Piotr 
Published: February 2018

AbstractObjectivesPALG CLL4 is the first, randomized, phase IIIb study with rituximab, cladribine, and cyclophosphamide (RCC) induction and subsequent maintenance with rituximab in previously untreated chronic lymphocytic leukemia (CLL) patients.MethodsThe induction treatment consisted of 6 RCC cycles regimen. Patients with complete response (CR) or partial response (PR) after an induction phase were randomized into a maintenance arm with rituximab or an observational arm.ResultsIn the intention‐to‐treat population, 97 patients completed the induction phase with an overall response rate (ORR) of 73.2% (CR 22.7%, PR 50.5%). Subsequently, 66 patients were randomized into the rituximab maintenance arm (n = 33) or the observational arm (n = 33). CR rates were 57.1% in the maintenance group vs 50% in the observational group. PFS was significantly longer in the rituximab maintenance vs the observational arm (P = .028). The multivariate Cox model indicated that del17p (P = .006) and elevated beta‐2‐microglobulin (P = .015) significantly increased the hazard ratio (HR) of progression, whereas the presence of CD38 (P = .013) significantly decreased it; maintenance therapy with rituximab (P < .0001) significantly decreased the HR of disease progression.ConclusionsThe study confirmed the high efficacy and acceptable safety profile of induction therapy with RCC and maintenance therapy with rituximab in previously untreated patients with CLL.
Correlates of economic decisions in the dorsal and subgenual anterior cingulate cortices
Authors: Azab Habiba , Hayden Benjamin Y. 
Published: February 2018

AbstractThe anterior cingulate cortex can be divided into distinct ventral (subgenual, sgACC) and dorsal (dACC), portions. The role of dACC in value‐based decision‐making is hotly debated, while the role of sgACC is poorly understood. We recorded neuronal activity in both regions in rhesus macaques performing a token‐gambling task. We find that both encode many of the same variables; including integrated offered values of gambles, primary as well as secondary reward outcomes, number of current tokens and anticipated rewards. Both regions exhibit memory traces for offer values and putative value comparison signals. Both regions use a consistent scheme to encode the value of the attended option. This result suggests that neurones do not appear to be specialized for specific offers (that is, neurones use an attentional as opposed to labelled line coding scheme). We also observed some differences between the two regions: (i) coding strengths in dACC were consistently greater than those in sgACC, (ii) neurones in sgACC responded especially to losses and in anticipation of primary rewards, while those in dACC showed more balanced responding and (iii) responses to the first offer were slightly faster in sgACC. These results indicate that sgACC and dACC have some functional overlap in economic choice, and are consistent with the idea, inspired by neuroanatomy, which sgACC may serve as input to dACC.
Extreme streams: species persistence and genomic change in montane insect populations across a flooding gradient
Authors: Poff N. LeRoy , Larson Erin I. , Salerno Patricia E. , Morton Scott G. , Kondratieff Boris C. , Flecker Alexander S. , Zamudio Kelly R. , Funk W. Chris 
Published: February 2018

AbstractThe ecological and evolutionary consequences of extreme events are poorly understood. Here, we tested predictions about species persistence and population genomic change in aquatic insects in 14 Colorado mountain streams across a hydrological disturbance gradient caused by a one in 500‐year rainfall event. Taxa persistence ranged from 39 to 77% across sites and declined with increasing disturbance in relation to species' resistance and resilience traits. For taxa with mobile larvae and terrestrial adult stages present at the time of the flood, average persistence was 84% compared to 25% for immobile taxa that lacked terrestrial adults. For two of six species analysed, genomic diversity (allelic richness) declined after the event. For one species it greatly expanded, suggesting resilience via re‐colonisation from upstream populations. Thus, while resistance and resilience traits can explain species persistence to extreme disturbance, population genomic change varies among species, challenging generalisations about evolutionary responses to extreme events at landscape scales.
Real‐life long‐term effectiveness of fingolimod in Swiss patients with relapsing‐remitting multiple sclerosis
Authors: Zecca C. , Roth S. , Findling O. , Perriard G. , Bachmann V. , Pless M. L. , Baumann A. , Kamm C. P. , Lalive P. H. , Czaplinski A. 
Published: February 2018

Background and purposeIn 2011, fingolimod was approved in Switzerland for the treatment of relapsing‐remitting multiple sclerosis (RRMS). The aim of the present study was to assess the effectiveness and retention of fingolimod in a real‐life Swiss setting, in which patients can receive fingolimod as both first‐ and second‐line treatment for RRMS.MethodsThis cross‐sectional, observational study with retrospective data collection was performed at 19 sites that comprised both hospitals and office‐based physicians across Switzerland. Sites were asked to document eligible patients in consecutive chronological order to avoid selection bias. Demographic and clinical data from 274 consenting adult patients with RRMS who had received treatment with fingolimod were analyzed.ResultsMean treatment duration with fingolimod was 32 months. Under fingolimod, 77.7% of patients remained free from relapses and 90.3% did not experience disability progression. The proportion of patients who were free from any clinical disease activity, i.e. without relapses and disability progression, was 72.1%. A total of 28.5% of patients had been RRMS treatment‐naïve prior to fingolimod therapy. High long‐term treatment retention rates ranging between 95.7% at 24 months and 87.8% at 36 months were observed.ConclusionIn this Swiss cohort of naïve and pre‐treated subjects with RRMS, the majority of patients under fingolimod treatment showed freedom from relapses and disability progression. In addition, treatment retention rate over 2 and 3 years was high, irrespective of previous treatment.
Architecture and hydration of the arginine‐binding site of neuropilin‐1
Authors: Mota Filipa , Fotinou Constantina , Rana Rohini R. , Chan A. W. Edith , Yelland Tamas , Arooz Mohamed T. , O'Leary Andrew P. , Hutton Jennie , Frankel Paul , Zachary Ian , Selwood David , Djordjevic Snezana 
Published: February 2018

Neuropilin‐1 (NRP1) is a transmembrane co‐receptor involved in binding interactions with variety of ligands and receptors, including receptor tyrosine kinases. Expression of NRP1 in several cancers correlates with cancer stages and poor prognosis. Thus, NRP1 has been considered a therapeutic target and is the focus of multiple drug discovery initiatives. Vascular endothelial growth factor (VEGF) binds to the b1 domain of NRP1 through interactions between the C‐terminal arginine of VEGF and residues in the NRP1‐binding site including Tyr297, Tyr353, Asp320, Ser346 and Thr349. We obtained several complexes of the synthetic ligands and the NRP1‐b1 domain and used X‐ray crystallography and computational methods to analyse atomic details and hydration profile of this binding site. We observed side chain flexibility for Tyr297 and Asp320 in the six new high‐resolution crystal structures of arginine analogues bound to NRP1. In addition, we identified conserved water molecules in binding site regions which can be targeted for drug design. The computational prediction of the VEGF ligand‐binding site hydration map of NRP1 was in agreement with the experimentally derived, conserved hydration structure. Displacement of certain conserved water molecules by a ligand's functional groups may contribute to binding affinity, whilst other water molecules perform as protein–ligand bridges. Our report provides a comprehensive description of the binding site for the peptidic ligands’ C‐terminal arginines in the b1 domain of NRP1, highlights the importance of conserved structural waters in drug design and validates the utility of the computational hydration map prediction method in the context of neuropilin.DatabaseThe structures were deposited to the PDB with accession numbers PDB ID: 5IJR, 5IYY, 5JHK, 5J1X, 5JGQ, 5JGI.
Interior failure mechanism and life prediction of surface‐treated 17Cr‐Ni steel under high and very high cycle fatigue
Authors: Nehila A. , Li W. , Zhao H. 
Published: February 2018

AbstractThe understanding of very high cycle fatigue (VHCF) mechanisms is critical to the development of life prediction approach. For this purpose, high cycle fatigue (HCF) and VHCF properties of a surface‐treated 17Cr‐Ni steel were investigated under axial loading with stress ratio of 0. This steel exhibits the constantly decreasing S‐N characteristics associated with the inclusion‐fisheye induced failure under the HCF and the inclusion‐FGA (fine granular area)‐fisheye induced failure under the VHCF. The cyclic pressing plays an important role in the FGA formation process, but the FGA still can be observed for the stress ratio of zero due to the slight crack closure effect. Two life modelling approaches associated with related failure mechanisms in the HCF and VHCF regimes are proposed based on the agreement between experimental and predicted results.
IL‐17A[G197G]—Association between NOx and gestational age in a South African birth cohort
Authors: Nansook P. , Naidoo R. N. , Muttoo S. , Asharam K. , Ramkaran P. , Phulukdaree A. , Chuturgoon A. A. 
Published: February 2018

SummaryInterleukin (IL‐)17A, plays a role in pathogenic defence, but is implicated in chronic inflammatory diseases, and has recently been associated with variable pregnancy outcomes. We investigated the role of maternal IL‐17‐[G197A]‐specific effects of third‐trimester IL‐17 mRNA expression, NOx exposure levels and other variables on gestational age, in the Mother and Child in the Environment (MACE) birth cohort in South Africa. A total of 327 participants were genotyped for IL‐17‐[G197A] by polymerase chain reaction restriction‐fragment length polymorphism (PCR‐RFLP). Quantitative real‐time PCR was used to quantitate IL‐17‐mRNA expression in whole blood. Multivariate linear regression analysis, stratified by IL‐17‐[G197A] genotype, was used to test for effects of NOx, IL17A/GAPDH, haemoglobin, body mass index, HIV‐1 positivity, maternal education and income level on gestational age. Lower expression was associated with the IL‐17‐GG versus GA in the cohort and HIV‐1‐negative group (p = .0007, p = .0058), while no difference was observed in the HIV‐1 positives. Elevated IL‐17A expression was observed in the high NOx exposure groups, within IL‐17[G197G] (p = .0004). IL‐17[G197G] was associated with PTB (p < .0001), and the PTB group had lower IL‐17A expression compared to the full‐term group (p = .0002). IL‐17 expression was associated with an increase in gestational age (p = .038), and NOx was associated with a decrease in gestational age in the IL‐17[G197G] model (p = .046).
The utility of bone marrow sampling in the diagnosis and staging of lymphoma in South Africa
Authors: Phillips L. , Opie J. 
Published: February 2018

AbstractIntroductionThe bone marrow biopsy (BMB) is a diagnostic and staging tool in lymphoma that remains practically useful and relevant in resource‐constrained settings, despite restricted applications in international staging guidelines, which favour less invasive nuclear medicine techniques.MethodsRetrospective laboratory data review of BMBs in adult lymphoma patients from 2005 to 2010 to determine subtypes, rates of bone marrow involvement (BMI), human immunodeficiency virus (HIV) seroprevalence and CD4 counts, trephine length and additional findings.ResultsA total of 1215 BMBs reported in lymphoma included 759 newly diagnosed patients, with BMI in 43.6% of non‐Hodgkin lymphoma (NHL) overall, 28.9% of high‐grade B subtypes and 35.7% of Hodgkin lymphoma (HL). HIV seroprevalence was 38.8%, 53.0% and 33.9% in the 3 respective groups. There was a statistical association between BMI and HIV seropositivity in Burkitt lymphoma and HL, and BMI and CD4 count in HIV‐related HL. Over 10% (n = 79) of new lymphoma cases were diagnosed by BMB with ancillary tests. Occasional histological discordance and transformation were reported in NHL. Focal/unilateral BMI was uncommon. Bilateral BMB and biopsy length exceeding 26 mm did not improve BMI detection.ConclusionIn the South African public sector, high HIV prevalence leads to a different lymphoma pathology profile from the developed world. High BMI rates are encountered. Here, and in similar resource‐constrained settings, international lymphoma staging guidelines can be logistically challenging and unaffordable. BMB remains useful in the staging and diagnosis of lymphoma. Unilateral sampling with a processed trephine length of at least 26 mm is recommended.
The contribution of mast cells to bacterial and fungal infection immunity
Authors: Piliponsky Adrian M. , Romani Luigina 
Published: February 2018

SummaryMast cells are hematopoietic progenitor‐derived, granule‐containing immune cells that are widely distributed in tissues that interact with the external environment, such as the skin and mucosal tissues. It is well‐known that mast cells are significantly involved in IgE‐mediated allergic reactions, but because of their location, it has also been long hypothesized that mast cells can act as sentinel cells that sense pathogens and initiate protective immune responses. Using mast cell or mast cell protease‐deficient murine models, recent studies by our groups and others indicate that mast cells have pleiotropic regulatory roles in immunological responses against pathogens. In this review, we discuss studies that demonstrate that mast cells can either promote host resistance to infections caused by bacteria and fungi or contribute to dysregulated immune responses that can increase host morbidity and mortality. Overall, these studies indicate that mast cells can influence innate immune responses against bacterial and fungal infections via multiple mechanisms. Importantly, the contribution of mast cells to infection outcomes depends in part on the infection model, including the genetic approach used to assess the influence of mast cells on host immunity, hence highlighting the complexity of mast cell biology in the context of innate immune responses.
Non‐IgE mediated mast cell activation
Authors: Redegeld Frank A. , Yu Yingxin , Kumari Sangeeta , Charles Nicolas , Blank Ulrich 
Published: February 2018

SummaryMast cells (MCs) are innate immune cells that are scattered in tissues throughout the organism being particularly abundant at sites exposed to the environment such as the skin and mucosal surfaces. Generally known for their role in IgE‐mediated allergies, they have also important functions in the maintenance of tissue integrity by constantly sensing their microenvironment for signals by inflammatory triggers that can comprise infectious agents, toxins, hormones, alarmins, metabolic states, etc. When triggered their main function is to release a whole set of inflammatory mediators, cytokines, chemokines, and lipid products. This allows them to organize the ensuing innate immune and inflammatory response in tight coordination with resident tissue cells, other rapidly recruited immune effector cells as well as the endocrine and exocrine systems of the body. To complete these tasks, MCs are endowed with a large repertoire of receptors allowing them to respond to multiple stimuli or directly interact with other cells. Here we review some of the receptors expressed on MCs (ie, receptors for Immunoglobulins, pattern recognition receptors, nuclear receptors, receptors for alarmins, and a variety of other receptors) and discuss their functional implication in the immune and inflammatory response focusing on non‐IgE‐mediated activation mechanisms.
Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?
Authors: Frossi Barbara , Mion Francesca , Sibilano Riccardo , Danelli Luca , Pucillo Carlo E. M. 
Published: February 2018

SummaryMast cells (MCs) are derived from committed precursors that leave the hematopoietic tissue, migrate in the blood, and colonize peripheral tissues where they terminally differentiate under microenvironment stimuli. They are distributed in almost all vascularized tissues where they act both as immune effectors and housekeeping cells, contributing to tissue homeostasis. Historically, MCs were classified into 2 subtypes, according to tryptic enzymes expression. However, MCs display a striking heterogeneity that reflects a complex interplay between different microenvironmental signals delivered by various tissues, and a differentiation program that decides their identity. Moreover, tissue‐specific MCs show a trained memory, which contributes to shape their function in a specific microenvironment. In this review, we summarize the current state of our understanding of MC heterogeneity that reflects their different tissue experiences. We describe the discovery of unique cell molecules that can be used to distinguish specific MC subsets in vivo, and discuss how the improved ability to recognize these subsets provided new insights into the biology of MCs. These recent advances will be helpful for the understanding of the specific role of individual MC subsets in the control of tissue homeostasis, and in the regulation of pathological conditions such as infection, autoimmunity, and cancer.
Police and mental health responses to mental health crisis in the Waikato region of New Zealand
Authors: Holman Graham , O'Brien Anthony John , Thom Katey 
Published: February 2018

AbstractNew Zealand police report a high level of involvement with people in mental health crisis, something that has been reported in the international literature in recent decades. Involvement of police represents a coercive pathway to care and is likely to be associated with use of force. The aim of this study was to investigate the clinical, legal, and social characteristics of individuals subject to police response in the Waikato region of New Zealand. Data were also collected on characteristics of police response, including use of force, time of day, and disposition. Use of force, most commonly use of handcuffs, occurred in 78% of cases involving police. The study showed that Māori were overrepresented in police responses, but no more likely than Europeans to experience use of force. Almost half those subject to police response were not subsequently admitted to hospital, raising questions about the need for and nature of police response in these cases. Because mental health nurses are often part of police response, nurses need to take cognisance of their relationship with police and contribute to any initiatives that can reduce coercion in the pathway to care, and improve service users' experience in mental health crises.