bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility and Acceptability of an Intervention Providing Computer-Generated Tailored Feedback to Target Alcohol Consumption and Depressive Symptoms in Proactively Recruited Health Care Patients and Reactively Recruited Media Volunteers: Results of a Pilot Study
Authors: Krause Kristian , Guertler Diana , Moehring Anne , Batra Anil , Eck Sandra , Rumpf Hans-Jürgen , Bischof Gallus , Lucht Michael , Freyer-Adam Jennis , Ulbricht Sabina , John Ulrich , Meyer Christian 
Published: March 2019

<b><i>Background:</i></b> A pre-post pilot study was conducted to test the feasibility, acceptability, and potential effectiveness of a fully automatized computer-based intervention targeting hazardous drinking and depressiveness in proactively recruited health care patients (HCPs). To address the importance of the sample selection when testing interventions, HCPs were compared to media recruited volunteers (MVs). <b><i>Method:</i></b> In a multicenter screening program 2,773 HCPs were screened for hazardous drinking and depressive symptoms. MVs were recruited via media solicitation. Over a period of 6 months, study participants received 6 individualized counseling letters and weekly short messages. Pre-post data were analyzed for 30 participants (15 HCPs, 15 MVs). Intervention acceptability was assessed in post-intervention interviews conducted with 32 study participants. <b><i>Results:</i></b> MVs showed higher problem severity and motivation to change than HCPs. Over the course of the intervention both subsamples reduced regular binge drinking (HCPs: <i>p</i> = 0.016; MVs: <i>p</i> = 0.031) and depressiveness (HCPs: <i>p</i> = 0.020; MVs: <i>p</i> &#x3c; 0.001). MVs further reduced average daily alcohol consumption (<i>p</i> = 0.034). The intervention received positive ratings from both subsamples, the alcohol module was rated more favorably by MVs than by HCPs (<i>p</i> = 0.012). Subsamples further differed in terms of intervention usage (<i>p</i> = 0.013). <b><i>Conclusion:</i></b> The intervention was technically and logistically feasible, well accepted, and may have the potential to reduce hazardous drinking and depressive symptoms in different populations. Subsamples differed in terms of problem severity, motivation to change, intervention usage, pre-post changes, and attitudes toward the intervention, showing that intervention development should involve the intended target populations to avoid biased conclusions on intervention effectiveness and acceptability.
Loss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy
Authors: Wang Chang , Ye Muyao , Zhao Qiulan , Xia Ming , Liu Di , He Liyu , Chen Guochun , Peng Youming , Liu Hong 
Published: March 2019

<b><i>Background:</i></b> Aberrant O-glycosylation IgA1 production is a major factor in the pathogenesis of IgA nephropathy, but the underlying mechanism is still unclear. IgA1 glycosylation modification is in Golgi, and downregulation of the Golgi peripheral membrane protein Golgi matrix protein 130 (GM130) could lead to glycosylation deficiency. In this study, we aimed to explore the role of GM130 in glycosylate deficiency IgA1 (Gd-IgA1) production. <b><i>Methods:</i></b> We enrolled 27 IgA nephropathy patients, 12 patients with chronic tonsillitis, 15 non-IgAN chronic kidney disease patients, and 15 healthy volunteers as healthy control. We explored GM130 expression in Tonsillar tissue by immunofluorescence staining and Western blotting and expression in peripheral blood mononuclear cells (PBMCs) by flow cytometry. The concentration of IgA1 and level of O-glycosylation were determined by ELISA and Vicia Villosa lectin-binding assay. Real-time PCR and Western blot were used to analyze the levels of β1,3-Gal transferase (C1GALT1) and ST6GalNAC2, respectively. To explore the contribution of GM130 in IgA1 O-glycosylation modification, cells were subjected to experiments for evaluation of GM130 silencing by GM130-siRNA transfection. <b><i>Results:</i></b> GM130 expression was significantly decreased in tonsil tissues and PBMC of IgAN patients; the expression of C1GALT1 decreased and Gd-IgA1 level increased significantly in patients with IgAN patients. The expression of GM130 was negatively related to Gd-IgA1 production. By siRNA transfection, our results clearly indicated that the downregulation of GM130 can increase IgA1 O-glycosylation deficiency, which is thought to reduce C1GALT1 expression but not affect the expression of ST6GalNAC2. <b><i>Conclusion:</i></b> We identified and demonstrated that GM130 plays an important role in IgA1 O-glycans deficiency in IgAN patients, by negatively regulating C1GALT1 expression. We believe that this finding will provide theoretical foundations for a new mechanism of Gd-IgA1 production in IgAN patients.
Patient‐Reported Reasons for Declining or Discontinuing Statin Therapy: Insights From the PALM Registry
Authors: Bradley Corey K. , Wang Tracy Y. , Li Shuang , Robinson Jennifer G. , Roger Veronique L. , Goldberg Anne C. , Virani Salim S. , Louie Michael J. , Lee L. Veronica , Peterson Eric D. , Navar Ann Marie 
Published: March 2019

Background
Many adults eligible for statin therapy for cardiovascular disease prevention are untreated. Our objective was to investigate patient‐reported reasons for statin underutilization, including noninitiation, refusal, and discontinuation.

Methods and Results
This study included the 5693 adults recommended for statin therapy in the PALM (Patient and Provider Assessment of Lipid Management) registry. Patient surveys evaluated statin experience, reasons for declining or discontinuing statins, and beliefs about statins and cardiovascular disease risk. Overall, 1511 of 5693 adults (26.5%) were not on treatment. Of those not on a statin, 894 (59.2%) reported never being offered a statin, 153 (10.1%) declined a statin, and 464 (30.7%) had discontinued therapy. Women (relative risk: 1.22), black adults (relative risk: 1.48), and those without insurance (relative risk: 1.38) were most likely to report never being offered a statin. Fear of side effects and perceived side effects were the most common reasons cited for declining or discontinuing a statin. Compared with statin users, those who declined or discontinued statins were less likely to believe statins are safe (70.4% of current users vs. 36.9% of those who declined and 37.4% of those who discontinued) or effective (86.3%, 67.4%, and 69.1%, respectively). Willingness to take a statin was high; 67.7% of those never offered and 59.7% of patients who discontinued a statin would consider initiating or retrying a statin.

Conclusions
More than half of patients eligible for statin therapy but not on treatment reported never being offered one by their doctor. Concern about side effects was the leading reason for statin refusal or discontinuation. Many patients were willing to reconsider statin therapy if offered.
The Great Aesthetic Inspiration
Authors: Sorgenfrei Simon 
Published: March 2019

Abstract
Ivan Aguéli is known not only as an artist but also as Sweden’s first (famous) convert to Islam and as an initiate in the Sufi order Shadhiliyya-Arabiyya. Sufism’s role in Aguéli’s life and its significance for his theory of art and style of painting have been analyzed primarily by Viveca Wessel (1988). This article will instead analyze Aguéli’s relationship to the writings of Emanuel Swedenborg (1688–1772), which extends far back in his life, and how they influenced Aguéli’s philosophy of religion and view of art.
Additional threat to Hynobius salamander eggs: predation by loaches (Misgurnus sp.) in agricultural wetlands
Authors: Bae Yoonhyuk , Kong Sungsik , Yi Yoonjung , Jang Yikweon , Borzée Amaël 
Published: March 2019

Abstract
Anthropogenic modifications of the environment have clear negative impacts on species. These effects may reach a higher magnitude in highly altered habitats, for example in wetlands transformed into rice paddies. This is the case for the amphibian species of the genus Hynobius in the Republic of Korea, which originally breed in slow streams and valleys. However, a comparatively high proportion of the natural breeding sites used by the species in the lowlands has been transformed into rice paddies. Here, we assessed whether anthropogenic modification of wetlands leads to an additional threat to breeding Hynobius spp. in the form of increased vulnerability of their egg clutches to loach predators (Misgurnus species) in such modified habitats. We conducted weekly occurrence surveys at 27 randomly selected sites in the Republic of Korea and recorded the following information: type of site (natural versus agricultural), air temperature, water conductivity, moon phase and predation by Misgurnus sp. Our results reveal, for the first time, cases of predation of Hynobius spp. eggs by Misgurnus loaches. We also show that the risk of predation was higher in agricultural sites in comparison to natural sites. In conclusion, we demonstrate the increased predation risk of Hynobius spp. eggs by Misgurnus sp. at anthropogenically disturbed sites, and thus a new type of threat to Hynobius populations. This new type of threat may, however, be due to expansion of the breeding habitats following human disruptions to landscapes. We therefore call for the development of mitigating measures to wetland modifications.
Two new species of Tryblionella W. SMITH (Bacillariaceae, Bacillariophyta) from a southern Brazil salt marsh
Authors: BERTOLLI LUCIELLE MERLYM , TALGATTI DÁVIA MARCIANA , NASCIMENTO THAMIRES MARIAH DA SILVEIRA , TORGAN LEZILDA CARVALHO 
Published: March 2019

Two new species of Tryblionella are described occurring both in epiphytic and microphytobenthic communities from Patos Lagoon salt marshes, Rio Grande do Sul, southern Brazil. Tryblionella confusa can be misidentified as T. debilis, since the examination under light microscopy provides few characters, besides that, the later species shows a wide amplitude of characters in the literature interfering in the identification. On the other hand, Tryblionella ornata exhibits more distinguishable features in light microscopy observation, which are reinforced by its singular pattern of ornamentation visible under scanning electron microscopy. The species were observed in all sites and periods studied, undergoing a wide range of salinity and pH. No preference of substrate was observed.
Sensorineural Hearing Loss in Leukemia: A Case Report Showing Intravascular Coagulation in the Cochlea and Vestibular Labyrinth
Authors: Okayasu Tadao , Faquin William C. , Nadol Joseph B. 
Published: March 2019

Introduction: Sensorineural hearing loss frequently has been described in patients with leukemia, and in fact, hearing loss may be the presenting symptom of this disease. However, the pathogenesis of sensorineural hearing loss in leukemia is not well understood. Objective: To describe the temporal bone histopathology in 1 patient with leukemia and sensorineural hearing loss. Methods: The histopathology of the temporal bones of 1 patient with chronic myelomonocytic leukemia who suffered well-documented bilateral sequential profound sensorineural hearing loss 4 months before death was investigated using light microscopy. Result: There was evidence of ischemic necrosis of the neuroepithelium and intravascular fibrin micro-thrombi suggestive of intravascular coagulation in the cochlea and vestibular labyrinth. Conclusion: Intravascular coagulation may be a contributing factor in the commonly reported finding of hemorrhage in the cochlea in leukemia and may play a role in the pathogenesis of sensorineural loss in some cases of leukemia.
The role of trauma and partner support in perinatal depression and parenting stress: An Australian pregnancy cohort study
Authors: Galbally Megan , Watson Stuart J , Boyce Philip , Lewis Andrew J 
Published: March 2019

Background: Improving our understanding of the relationship between maternal depression and parenting stress is likely to lie in the range of additional factors that are associated with vulnerability to depression and also to parenting stress. Objectives: To examine the role of trauma and partner support, in understanding the relationship between perinatal depression and parenting stress. Methods: This study utilises data from 246 women in a pregnancy cohort study that followed women from early pregnancy until their infant was 12 months. Included were both women with a diagnosis of depression and those without depression. The measures included Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Edinburgh Postnatal Depression Scale, Childhood Trauma Questionnaire, Social Support Effectiveness Questionnaire and the Parenting Stress Index. Results: We found women with depression were more likely to report a history of childhood trauma. Depressive symptoms were positively associated with parenting stress while partner support was negatively associated with parenting stress. The protective role of partner support for parenting distress was observed in those with no history of childhood abuse and low depressive symptoms, but not in those with a trauma history and high depressive symptoms. Conclusions: These findings highlight the importance of early trauma in understanding the protective role of support on the relationship between parenting and depression. These findings can inform future studies and the refinement of future interventions aimed at both perinatal depression and parenting.
Disclosing the diagnosis of schizophrenia: A pilot study of the ‘Coming Out Proud’ intervention
Authors: Setti Viviane Piagentini Candal , Loch Alexandre Andrade , Modelli Arlete , de Almeida Rocca Cristiana Castanho , Hungerbuehler Ines , van de Bilt Martinus Theodorus , Gattaz Wagner Farid , Rössler Wulf 
Published: March 2019

Background: Schizophrenia is one of the most stigmatized psychiatric disorders, and disclosing it is often a source of stress to individuals with the disorder. The Coming Out Proud (COP) group intervention is designed to reduce the stigma’s negative impact and help participants decide if they want to disclose their disorder. Aims: To assess the effect of the COP intervention in individuals with the diagnosis of schizophrenia. Methods: A pilot study of 3 2-hour group lessons (6–12 participants) per week. Individuals were selected from three specialized outpatient services in São Paulo, Brazil; 46 people were willing to participate, 11 dropped out during the intervention and 4 were excluded due to low intelligence quotient (IQ), resulting in a final sample of 31 participants. Outcomes were assessed before ( T0/baseline) and after ( T1/directly) after the COP intervention, and at 3-week follow-up ( T2/3 weeks after T1). We applied eight scales, of which four scales are analyzed in this article (Coming Out with Mental Illness Scale (COMIS), Cognitive Appraisal of Stigma as a Stressor (CogApp), Self-Stigma of Mental Illness Scale-Short Form (SSMIS) and Perceived Devaluation-Discrimination Questionnaire (PDDQ)). Results: People who completed the COP intervention showed a significant increase in the decision to disclose their diagnosis (22.5% in T0 vs 67.7% in T2). As to the perception of stigma as a stressor, mean values significantly increased after the intervention ( T0 = 3.83, standard deviation ( SD) = .92 vs T2 = 4.44, SD = 1.05; p = .006). Two results had marginal significance: self-stigma was reduced ( T0 = 3.10, SD = 1.70 vs T2 = 2.73, SD = 1.87; p = .063), while perceived discrimination increased ( T0 = 2.68, SD = .55 vs T2 = 2.93, SD = .75; p = .063). Conclusion: This study suggests that the COP group intervention facilitated participants’ disclosure decisions, and the increasing awareness of stigma as a stressor in life may have facilitated their decision to eventually disclose their disorder. The results raise questions that require further analysis, taking sociocultural factors into account, as stigma is experienced differently across cultures.
The Significance of Specialist Teachers of Learners with Visual Impairments as Agents of Change: Examining Personnel Preparation in the United Kingdom through a Bioecological Systems Theory
Authors: McLinden Mike , Ravenscroft John , Douglas Graeme , Hewett Rachel , Cobb Rory 
Published: March 2019

Introduction The unique challenges to learning and participation in education associated with visual impairment are well documented in the literature, as is the importance of addressing these challenges through ensuring practitioners who support them are equipped with appropriate knowledge, understanding, and skills. We use a bioecological systems theory as a lens through which to examine the personnel preparation of vision specialist teachers to act as agents of change. We draw on the different teacher preparation programs for specialist teachers of learners with visual impairments in the United Kingdom to demonstrate how this theory can be applied. Methods We use a bounded case study to bring together the respective teacher preparation programs in the UK in order to demonstrate complementary characteristics of the theoretical model proposed. Results and discussion We argue that a bioecological systems theory offers a holistic framework for educators involved in personnel preparation to explicitly engage with vision specialist teachers in their role as potential agents of change. This preparation includes developing distinctive knowledge, understanding, and skills to facilitate learner participation in education through promoting “progressive” and “mutual” accommodation between the active learner and the changing learning environments in order to achieve successful outcomes. Implications for practitioners The article is original in applying a bioecological systems theory to the preparation of these specialist teachers, with a focus on their role as agents of change. We argue that it has significance, therefore, for practitioners and researchers concerned with the personnel preparation of other practitioners for learners with distinctive educational needs across national contexts and settings.
The experience of family caregivers of patients with cancer in an Asian country: A grounded theory approach
Authors: Kristanti Martina Sinta , Effendy Christantie , Utarini Adi , Vernooij-Dassen Myrra , Engels Yvonne 
Published: March 2019

Background: Strong family bonds are part of the Indonesian culture. Family members of patients with cancer are intensively involved in caring, also in hospitals. This is considered “normal”: a societal and religious obligation. The values underpinning this might influence families’ perception of it. Aim: To explore and model experiences of family caregivers of patients with cancer in Indonesia in performing caregiving tasks. Design: A grounded theory approach was applied. The constant comparative method was used for data analysis and a paradigm scheme was employed for developing a theoretical model. Setting/participants: The study was conducted in three hospitals in Indonesia. The participants were family caregivers of patients with cancer. Results: A total of 24 family caregivers participated. “Belief in caregiving” appeared to be the core phenomenon. This reflects the caregivers’ conviction that providing care is an important value, which becomes the will power and source of their strength. It is a combination of spiritual and religious, value and motivation to care, and is influenced by contextual factors. It influences actions: coping mechanisms, sharing tasks, and making sacrifices. Social support influences the process of the core phenomenon and the actions of the caregivers. Both positive and negative experiences were identified. Conclusion: We developed a model of family caregivers’ experiences from a country where caregiving is deeply rooted in religion and culture. The model might also be useful in other cultural contexts. Our model shows that the spiritual domain, not only for the patient but also for the family caregivers, should be structurally addressed by professional caregivers.
The trajectory of functional decline over the last 4 months of life in a palliative care population: A prospective, consecutive cohort study
Authors: Morgan Deidre D , Tieman Jennifer J , Allingham Samuel F , Ekström Magnus P , Connolly Alanna , Currow David C 
Published: March 2019

Background: Understanding current patterns of functional decline will inform patient care and has health service and resource implications. Aim: This prospective consecutive cohort study aims to map the shape of functional decline trajectories at the end of life by diagnosis. Design: Changes in functional status were measured using the Australia-modified Karnofsky Performance Status Scale. Segmented regression was used to identify time points prior to death associated with significant changes in the slope of functional decline for each diagnostic cohort. Sensitivity analyses explored the impact of severe symptoms and late referrals, age and sex. Setting/participants: In all, 115 specialist palliative care services submit prospectively collected patient data to the national Palliative Care Outcomes Collaboration across Australia. Data on 55,954 patients who died in the care of these services between 1 January 2013 and 31 December 2015 were included. Results: Two simplified functional decline trajectories were identified in the last 4 months of life. Trajectory 1 has an almost uniform slow decline until the last 14 days of life when function declines more rapidly. Trajectory 2 has a flatter more stable trajectory with greater functional impairment at 120 days before death, followed by a more rapid decline in the last 2 weeks of life. The most rapid rate of decline occurs in the last 2 weeks of life for all cohorts. Conclusions: Two simplified trajectories of functional decline in the last 4 months of life were identified for five patient cohorts. Both trajectories present opportunities to plan for responsive healthcare that will support patients and families.
Appropriate frameworks for economic evaluation of end of life care: A qualitative investigation with stakeholders
Authors: Kinghorn Philip , Coast Joanna 
Published: March 2019

Background: The use of quality-adjusted life years rests on the assertion that the objective of the health care system is to improve health. Aim: To elicit the views of expert stakeholders on the purpose and evaluation of supportive end of life care, and explore how different purposes of end of life care imply the need for different evaluative frameworks. Design: Semi-structured qualitative interviews, analysed through an economic lens using a constant comparative approach. Participants: Twenty professionals working in or visiting the United Kingdom or Republic of Ireland, with clinical experience and/or working as academics in health-related disciplines. Results: Four purposes of end of life care were identified from and are critiqued with the aid of the qualitative data: to improve health, to enable patients to die in their preferred place, to enable the patient to experience a good death, and to enable the patient to experience a good death, and those who are close to the patient to have an experience which is as free as possible from fear, stress and distress. Conclusion: Managing symptoms and reducing anxiety were considered to be core objectives of end of life care and fit with the wider health service objective of improving/maximising health. A single objective across the entire health system ensures consistency in the way that resource allocation is informed across that entire system. However, the purpose of care at the end of life is more complex, encompassing diverse and patient-centred objectives which we have interpreted as enabling the patient to experience a good death.