bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain ischemic insult induces cofilin rod formation leading to synaptic dysfunction in neurons
Authors: Shu Liang , Chen Ben , Chen Bin , Xu Hai , Wang Guoxiang , Huang Yian , Zhao Yingya , Gong Hui , Jiang Min , Chen Lidian , Liu Xu , Wang Yun 
Published: June 2018

Ischemic stroke not only induces neuron death in the infarct area but also structural and functional damage of the surviving neurons in the surrounding peri-infarct area. In the present study, we first identified cofilin rod, a pathological rod-like aggregation, formed in neurons of in vivo ischemic stroke animal model and induced neuronal impairment. Cofilin rods formed only on the ipsilateral side of the middle cerebral artery occlusion and reperfusion (MCAO-R) rat brain and showed the highest density in peri-infarct area. Our real-time live cell imaging, immunostaining and patch clamp studies showed that cofilin rod formation in neurons led to dendritic mitochondrial transportation failure, as well as impairment of synaptic structure and functions. Overexpression of LIM kinase or activation of its upstream regulator Rho, suppressed ischemia-induced cofilin rod formation and showed protective effect on synaptic function and structure impairment in both cultured neurons and MCAO-R rat model. In summary, our results demonstrate a novel mechanism of ischemic stroke-induced neuron injury in peri-infarct area and provide a potential target for the protection of neuronal structure and function against brain ischemia insult.
Do Breast Implants Influence Breastfeeding? A Meta-Analysis of Comparative Studies
Authors: Cheng Fengrui , Dai Shuiping , Wang Chiyi , Zeng Shaoxue , Chen Junjie , Cen Ying 
Published: June 2018

Background: Aesthetic breast implant augmentation surgery is the most popular plastic surgery worldwide. Many women choose to receive breast implants during their reproductive ages, although the long-term effects are still controversial. Research aim: We conducted a meta-analysis to assess the influence of aesthetic breast augmentation on breastfeeding. We also compared the exclusive breastfeeding rates of periareolar versus inframammary incision. Methods: A systematic search for comparative studies about breast implants and breastfeeding was performed in PubMed, MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ScienceDirect, Scopus, and Web of Science through May 2018. Meta-analysis was conducted with a random-effects model (or fixed effects, if heterogeneity was absent). Results: Four cohorts and one cross-sectional study were included. There was a significant reduction in the exclusive breastfeeding rate for women with breast implants compared with women without implants, pooled relative risk = 0.63, 95% confidence interval [0.46, 0.86], as well as the breastfeeding rate, pooled relative risk = 0.88, 95% confidence interval [0.81, 0.95]. There was no evidence that periareolar incision was associated with a reduction in the exclusive breastfeeding rate, pooled relative risk = 0.84, 95% confidence interval [0.45, 1.58]. Conclusion: Participants with breast implants are less likely to establish breastfeeding, especially exclusive breastfeeding. Periareolar incision does not appear to reduce the exclusive breastfeeding rate.
Association of ABO blood groups and Rh factor with retinal and choroidal thickness
Authors: Teberik Kuddusi , Eski Mehmet Tahir 
Published: June 2018

Purpose: To evaluate if ABO blood group and Rh factor have an effect on retinal and choroidal thickness. Methods: This study was designed prospectively. Retinal nerve fiber layer, retinal, and choroidal thicknesses were measured with spectral-domain optical coherence tomography. Retinal and choroidal thickness measurements (one subfoveal, three temporal, and three nasal) were obtained at 500-μm intervals up to 1500 μm with the caliper system. Results: In this study, 109 male and 151 female, 260 individuals in total were included. There were 125 subjects in group A, 29 in group B, 34 in group AB, and 72 in group O. Rh factor was positive in 194 subjects and negative in 66. There was no significant difference between the groups regarding age (p = 0.667). The groups did not show any statistical difference in retinal nerve fiber layer thickness. There was significant difference found for mean retinal thickness at temporal 1000 μm when four groups were compared (p = 0.037). No statistically significant difference was detected for the remaining retinal and choroidal sectoral regions. The groups did not statistically significantly differ concerning Rh factor (p > 0.05). Conclusion: Although we found a significant difference in retinal thickness in the temporal retina between group B with group A and group O, we suggest that both blood group and Rh factor have no effect on retinal and choroidal thickness.
Safety and Predictive Factors of Short-Term Efficacy of a Single Injection of Mannitol-Modified Cross-Linked Hyaluronic Acid in Patients with Trapeziometacarpal Osteoarthritis. Results of a Multicentre Prospective Open-Label Pilot Study (INSTINCT Trial)
Authors: Dauvissat Jérémy , Rizzo Christophe , Lellouche Henri , Porterie Jérôme , Melac-Ducamp Sylvie , Locquet Vincent , Travers Vincent , Maillet Bernard , Conrozier Thierry 
Published: June 2018

Purpose: To assess safety and search predictive factors of efficacy of a single intra-articular injection of a mannitol-modified hyaluronic acid (HA) viscosupplement, in patients having trapeziometacarpal (TMC) osteoarthritis (OA). Methods: Patients with symptomatic TMC OA, not adequately relieved by analgesic therapy and/or by the use of a thumb splint, were included in a 3-month prospective multicentre open-label trial. All underwent plain radiographs with the Kapandji incidences allowing the Dell radiological grade assessment (1-4). Primary end point was the variation between injection (D0) and day 90 (D90) of the thumb pain (11-point Likert scale). Treatment consisted in a single injection of 0.6 to 1 mL of a viscosupplement made of a cross-linked HA combined with mannitol. All injections were performed under imaging guidance. Predictive factors of pain decrease were studied in univariate and multivariate analysis. Results: A total of 122 patients (76% women, mean age 60, mean disease duration 36 months) were included and 120 (98%) were assessed at 3 months. The TMC OA was of Dell’s grade 1, 2, 3, and 4 in 23%, 36.8%, 36.8%, and 3.5% of cases, respectively. At D0, the average (SD) pain level was 6.5 ± 1.6 without significant difference between Dell groups ( P = .21). At day 90, pain decreased from 6.5 ± 1.6 to 3.9 ± 2.5 (difference −2.7 ± 2.5; −42%; P < .0001) without significant difference between Dell grade ( P = .055), despite a seemingly smaller number of responders in stage 2 patients. The average analgesic consumption decreased in more than 1 out of 2 patients. In multivariate analysis, no predictor of response was identified. There was no safety issue. All adverse events (11%) were transient increase in pain during or following HA administration and resolved without sequel within 1 to 7 days. Conclusions: This study suggests that a single course of HANOX-M-XL injection is effective in relieving pain in patients with TMC OA, without safety concern. Patients with advanced stage of OA benefit the treatment as much as those with mild or moderate OA.
Bilingual and monolingual children’s articulation rates during nonword repetition tasks
Authors: Gibson Todd A , Jarmulowicz Linda , Oller D Kimbrough 
Published: June 2018

Aims and objectives: We know little about how the rate of speaking develops in bilingual children. The purpose of the current investigation was to explore the second language (L2) articulation rate in Spanish-English bilingual kindergarten children, and to compare the rates with those of monolingual English-speaking peers. Method/design: We performed a group-level, longitudinal study comparing articulation rates in two language groups (monolingual and bilingual). Data and analysis: Sixty-two monolingual English-speaking children and 62 Spanish-English bilingual peers repeated English-based nonwords of two-, three-, and four-syllable length; half contained complex syllable constructions (i.e., consonant clusters). Accuracy was treated as a measure of phonological knowledge. Articulatory duration for each nonword production was calculated, and duration measures were converted to syllables per second. English standardized vocabulary and phonological processing tests also were administered. Follow-up analyses compared a subsample of 19 Spanish-dominant children to 19 monolingual peers with relatively high language performance. Results: Bilingual children’s scores were significantly lower than those of their monolingual peers for English vocabulary, nonword repetition accuracy, and phonological processing. Despite this discrepancy, there was no statistically significant difference in the articulation rates of the two language groups either at the beginning or end of kindergarten. Nonwords with more frequent English phonological patterns were produced faster than nonwords with less frequent phonological patterns. Despite their increase in English language skills across the school year, neither language group experienced accompanying differences in articulation rate. Conclusions: These results demonstrate that Spanish-English bilingual children’s articulation rate while repeating nonwords of various length and complexity is similar to that of monolingual children’s, despite the bilingual children’s limited English phonological knowledge as measured by nonword repetition accuracy and sound matching. This runs contrary to expectations based on mainstream models that rely on frequency effects. We speculate that bilingual performance might be related to peer influences secondary to L2 immersion.
Patient-Reported Outcomes Following Fasciotomy for Chronic Exertional Compartment Syndrome
Authors: Maher Jacqueline M. , Brook Emily M. , Chiodo Christopher , Smith Jeremy , Bluman Eric M. , Matzkin Elizabeth G. 
Published: June 2018

Background. Lower extremity chronic exertional compartment syndrome (CECS) can negatively affect exercise and activity and may require operative intervention to release the fascia. Few studies have evaluated or compared patient-reported outcomes for bilateral versus single-leg staged fasciotomy and number of compartments released. Methods. A total of 27 eligible patients who underwent a fasciotomy procedure for CECS at a single institution were identified. A retrospective review of the medical record was performed, and individuals were contacted by phone to collect patient-reported outcomes, including ability to return to desired exercise level, postoperative expectation assessment, European Quality of Life—Five Dimensions, and the Foot and Ankle Ability Measure sports subscale. Results. A total of 21 patients were available for follow-up (average follow-up 36.9 months). The average single numeric assessment evaluation of lower-extremity function in sport was 87.5% in those who underwent a simultaneous bilateral fasciotomy (n = 10), 94% in those who had a staged unilateral fasciotomy (n = 5), and 74% in those who underwent an isolated single-leg fasciotomy. In all, 91% (n = 10) of patients who had all 4 compartments released intra-operatively were able to return to their desired exercise level versus 66.7% (n = 6) of those who did not have all 4 compartments released. Conclusion. The patient-reported outcomes of a staged unilateral fasciotomy and simultaneous bilateral fasciotomy for CECS are similar. Those who did not have all 4 compartments released reported worse outcomes. Further research should be conducted on the short-term outcomes and cost-effectiveness of a bilateral versus staged fasciotomy procedure. Levels of Evidence: Level IV: Case series
Fine-Needle Aspiration Biopsy for Molecular Genomic Classification: Evaluation of Transscleral vs Transvitreal Biopsy
Authors: Villegas Victor M. , Gold Aaron , Murray Timothy G. 
Published: June 2018

Purpose: To evaluate the transvitreal and transscleral fine-needle aspiration biopsy (FNAB) approach for molecular classification with gene-expression profiling (GEP) of uveal melanoma. Methods: Institutional review board–approved single-surgeon retrospective analysis of a consecutive case series of all patients undergoing FNAB using a 25-gauge-needle multipass approach for GEP analysis of uveal melanoma between 2012 and 2016. All FNAB specimens were processed for uveal melanoma diagnostic testing using a standard processing approach, and all testing was completed at a single laboratory (Castle Biosciences, Inc.). Results: Three hundred fifty-three eyes (353 patients) were included. Transvitreal biopsies were performed in 216 eyes (216/353, 61.2%), whereas transscleral biopsies were performed in 137 eyes (137/353, 38.8%). Twenty biopsies exhibited multiple gene failure (20/353, 5.6%). Excessive fluid biopsy volume was the primary association with reported multiple gene failure, occurring in 10 of 20 eyes (50%). FNAB performed via the transvitreal approach was significantly more likely to have an excessive volume report compared with transscleral biopsy (18/216, 8.3% vs 1/137, 0.7%; P < .001). Conclusions: FNAB performed via a transscleral or transvitreal multipass approach utilizing a 25-gauge needle achieves molecular classification in 95% of all patients undergoing treatment for presumed uveal melanoma independent of tumor size. Complications related to FNAB using these techniques are rare and may be associated with the presentation of the uveal melanoma.
Earthquake-induced rock shear through a deposition hole: Laboratory tests on bentonite-material models and modelling of three scale tests
Authors: Börgesson Lennart , Dueck Ann , Hernelind Jan 
Published: June 2018

ABSTRACTEarthquake-induced rock shear through a bentonite-filled deposition hole in a repository for spent nuclear fuel is an important scenario for the safety analysis because it may cause substantial damage to the canister hosting the spent fuel. Appropriate tools to investigate the effects on the buffer and the canister are required.The study described here explored the laboratory tests conducted to develop a material model of the bentonite buffer to be used in the simulations, the material models that these tests have provided and finite element (FE) simulations of three scale tests of a rock shear for comparison between modelled and measured results. The results were used for validation of the material models and the calculation technique that was used for modelling different rock-shear cases.The laboratory study consisted of swelling-pressure tests and tests to determine shear strength and stress-strain properties. The material model is elastic-plastic with a nonlinear stress-strain relation which depends on the density of the bentonite buffer and is a function of the strain rate. The three scale tests were modelled using theAbaqusfinite element code. Good agreement between modelled and measured results was observed, in spite of the complexity of the models and the difficulties associated with measuring stresses and strains under the very fast shear.The modelling results thus validate the modelling of the SR-Site. The modelling technique, the element mesh and the material models used in these analyses are well fitted and useful for this type of modelling.
Alk5/Runx1 signaling mediated by extracellular vesicles promotes vascular repair in acute respiratory distress syndrome
Authors: Shah Trushil , Qin Shanshan , Vashi Mona , Predescu Dan N. , Jeganathan Niranjan , Bardita Cristina , Ganesh Balaji , diBartolo Salvatore , Fogg Louis F. , Balk Robert A. , Predescu Sanda A. 
Published: June 2018

AbstractBackgroundPulmonary endothelial cells’ (ECs) injury and apoptotic death are necessary and sufficient for the pathogenesis of the acute respiratory distress syndrome (ARDS), regardless of epithelial damage. Interaction of dysfunctional ECs with circulatory extracellular vesicles (EVs) holds therapeutic promise in ARDS. However, the presence in the blood of long‐term ARDS survivors of EVs with a distinct phenotype compared to the EVs of non‐surviving patients is not reported. With a multidisciplinary translational approach, we studied EVs from the blood of 33 patients with moderate‐to‐severe ARDS.ResultsThe EVs were isolated from the blood of ARDS and control subjects. Immunoblotting and magnetic beads immunoisolation complemented by standardized flow cytometry and nanoparticles tracking analyses identified in the ARDS patients a subset of EVs with mesenchymal stem cell (MSC) origin (CD73+CD105+Cd34−CD45−). These EVs have 4.7‐fold greater counts compared to controls and comprise the transforming growth factor‐beta receptor I (TβRI)/Alk5 and the Runx1 transcription factor. Time course analyses showed that the expression pattern of two Runx1 isoforms is critical for ARDS outcome: the p52 isoform shows a continuous expression, while the p66 is short‐lived. A high ratio Runx1p66/p52 provided a survival advantage, regardless of age, sex, disease severity or length of stay in the intensive care unit. Moreover, the Runx1p66 isoform is transiently expressed by cultured human bone marrow‐derived MSCs, it is released in the EVs recoverable from the conditioned media and stimulates the proliferation of lipopolysaccharide (LPS)‐treated ECs. The findings are consistent with a causal effect of Runx1p66 expression on EC proliferation. Furthermore, morphological and functional assays showed that the EVs bearing the Runx1p66 enhanced junctional integrity of LPS‐injured ECs and decreased lung histological severity in the LPS‐treated mice.ConclusionsThe expression pattern of Runx1 isoforms might be a reliable circulatory biomarker of ARDS activity and a novel determinant of the molecular mechanism for lung vascular/tissue repair and recovery after severe injury.
The role of CD133 in cancer: a concise review
Authors: Glumac Paige M. , LeBeau Aaron M. 
Published: June 2018

AbstractDespite the abundant ongoing research efforts, cancer remains one of the most challenging diseases to treat globally. Due to the heterogenous nature of cancer, one of the major clinical challenges in therapeutic development is the cancer's ability to develop resistance. It has been hypothesized that cancer stem cells are the cause for this resistance, and targeting them will lead to tumor regression. A pentaspan transmembrane glycoprotein, CD133 has been suggested to mark cancer stem cells in various tumor types, however, the accuracy of CD133 as a cancer stem cell biomarker has been highly controversial. There are numerous speculations for this, including differences in cell culture conditions, poor in vivo assays, and the inability of current antibodies to detect CD133 variants and deglycosylated epitopes. This review summarizes the most recent and relevant research regarding the controversies surrounding CD133 as a normal stem cell and cancer stem cell biomarker. Additionally, it aims to establish the overall clinical significance of CD133 in cancer. Recent clinical studies have shown that high expression of CD133 in tumors has been indicated as a prognostic marker of disease progression. As such, a spectrum of immunotherapeutic strategies have been developed to target these CD133pos cells with the goal of translation into the clinic. This review compiles the current therapeutic strategies targeting CD133 and discusses their prognostic potential in various cancer subtypes.
Okun coefficients and participation coefficients by age and gender
Authors: Evans Andrew 
Published: June 2018

AbstractEstimates of the Okun coefficient are made for Australian workers grouped by age and gender using an unobserved components model. By analogy we define and estimate a participation coefficient which measures the cyclical response of the labour force participation rate to cyclical output shocks. The trend and cycle decomposition methodology used here leads to higher absolute estimates of the Okun coefficient than those typically found in the literature, although we find a pattern of variation in the coefficient by age and gender which is typical. We also find that, in aggregate, participating males in the middle age groups tend to stay in the labour force throughout the business cycle whereas females of the same age tend to participate procyclically. This has policy implications for attempts to increase the rate of participation of particular groups by age and gender following a cyclical downturn.
Is Running Better than Walking for Reducing Hip Joint Loads?
Authors: SCHACHE ANTHONY G. , LIN YI-CHUNG , CROSSLEY KAY M. , PANDY MARCUS G. 
Published: June 2018

ABSTRACT

Purpose
Knowledge of hip biomechanics during locomotion is necessary for designing optimal rehabilitation programs for hip-related conditions. The purpose of this study was to: 1) determine how lower-limb muscle contributions to the hip contact force (HCF) differed between walking and running; and 2) compare both absolute and per-unit-distance (PUD) loads at the hip during walking and running.

Methods
Kinematic and ground reaction force data were captured from eight healthy participants during overground walking and running at various steady-state speeds (walking: 1.50 ± 0.11 m·s−1 and 1.98 ± 0.03 m·s−1; running: 2.15 ± 0.18 m·s−1 and 3.47 ± 0.11 m·s−1). A three-dimensional musculoskeletal model was used to calculate the HCF as well as lower-limb muscular contributions to the HCF in each direction (posterior–anterior; inferior–superior; lateral–medial). The impulse of the resultant HCF was calculated as well as the PUD impulse (BW·s·m−1) and PUD force (BW·m−1).

Results
For both walking and running, HCF magnitude was greater during stance than swing and was largest in the inferior–superior direction and smallest in the posterior–anterior direction. Gluteus medius, iliopsoas, and gluteus maximus generated the largest contributions to the HCF during stance, whereas iliopsoas and hamstrings generated the largest contributions during swing. When comparing all locomotion conditions, the impulse of the resultant HCF was smallest for running at 2.15 m·s−1 with an average magnitude of 2.14 ± 0.31 BW·s, whereas the PUD impulse and force were smallest for running at 3.47 m·s−1 with average magnitudes of 0.95 ± 0.18 BW·s·m−1 and 1.25 ± 0.24 BW·m−1, respectively.

Conclusions
Hip PUD loads were lower for running at 3.47 m·s−1 compared with all other locomotion conditions because of a greater distance travelled per stride (PUD impulse) or a shorter stride duration combined with a greater distance travelled per stride (PUD force).