bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Activity of Nivolumab for Human Papilloma Virus-Related Juvenile-Onset Recurrent Respiratory Papillomatosis
Authors: Creelan Ben C. , Ahmad M. Usman , Kaszuba Frank J. , Khalil Farah K. , Welsh Allison W. , Ozdemirli Metin , Grant Nazaneen N. , Subramaniam Deepa S. 
Published: March 2019

Abstract

Background
Juvenile-onset recurrent respiratory papillomatosis (JO-RRP) is a human papilloma virus-mediated progressive benign neoplasm that affects children and young adults. Primary management consists of regular surgical debulking to maintain airway patency and vocal function. Like condyloma acuminata, JO-RRP is associated with immune dysregulation, and T cells isolated from papillomas express an anergic phenotype. Therefore, we hypothesized that programmed death protein 1 axis inhibition could stabilize tumor growth.

Materials and Methods
We treated two patients with refractory JO-RRP using nivolumab, with the primary objective of assessing clinical activity. We explored baseline papilloma features using immunohistochemistry and comprehensive genomic profiling.

Results
Both patients experienced symptomatic improvement, and interval laryngoscopies revealed a reduction in papillomatosis burden. One patient has not required subsequent surgical debridement for almost 2 years. On pathologic examination of pretreatment papillomas from both cases, infiltrating T cells were evident in the papilloma stroma, and papilloma programmed death ligand 1 expression was absent. Papilloma mutational load ranged between three and six mutations per megabase for each case. From on-treatment biopsy tissue, a higher amount of intraepithelial T cells and programmed death ligand 1 expression were detected in the papilloma.

Conclusion
Nivolumab appears to have promising activity in JO-RRP, and further clinical investigation with more patients in clinical trials is warranted.
Increased Mortality with Repeat Lumpectomy Alone After Ipsilateral Breast Tumor Recurrence
Authors: Su Yonghui , Guo Rong , Xue Jingyan , Chi Yayun , Chi Weiru , Wang Jia , Yang Benglong , Wu Jiong 
Published: March 2019

Abstract

Background
The benefit of repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery is currently inconclusive.

Materials and Methods
Patients with IBTR with definitive surgery were identified in the Surveillance, Epidemiology, and End Results registry between 1973 and 2013. The effect of different IBTR surgeries on overall and cancer-specific mortality was assessed using risk-adjusted Cox proportional hazard regression modeling and stratified propensity score-matching analysis (PSMA).

Results
Of the 5,098 patients with IBTR, 4,048 (79.4%) women underwent mastectomy and 1,050 (20.1%) underwent repeat lumpectomy. In multivariable Cox regression analysis, repeat lumpectomy was associated with increased overall mortality (hazard ratio for death [HR], 1.522; 95% confidence interval [CI], 1.317–1.759; p &lt; .001) and cancer-specific mortality (HR, 1.666; 95% CI, 1.319–2.105; p &lt; .001). Similar HRs were derived from the PSMA cohort. However, we found no significant difference in overall mortality for women who underwent repeat lumpectomy followed by radiation therapy (RT) compared with that for those who underwent mastectomy. Moreover, patients with IBTR with small tumors (≤1 cm) who underwent repeat lumpectomy with RT rather than without had similar overall and cancer-specific survival rates to those who underwent mastectomy.

Conclusion
Our investigation suggests that compared with mastectomy, repeat lumpectomy for IBTR is associated with higher overall and cancer-specific mortality under real-world observational conditions. Furthermore, repeat lumpectomy with RT is equivalent to mastectomy with respect to overall mortality and may influence treatment decision making for patients with small IBTR.

Implications for Practice
Although mastectomy has been regarded as the standard treatment for ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery, many patients diagnosed with small and early-detected recurrent tumor might be technically suitable for a less invasive surgical procedure. However, different studies have drawn inconsistent conclusions. The present study is a population-based analysis, which demonstrated the overall unfavorable impact of repeat lumpectomy over mastectomy on survival outcomes for patients with IBTR. However, patients with small IBTR (≤1 cm) that can tolerate radiation therapy may be the optimal candidates for repeat lumpectomy.
Admission test cardiotocography in labour as a predictor of foetal outcome in high risk pregnancies
Authors: Kumar Anvesha , Jaju Purshottam Bantaklal 
Published: March 2019

Background: Continuous fetal heart monitoring in all pregnant women in labour has gained prominence in obstetric practice in the recent years. The aim of this study was to emphasize on the role of admission cardiotocography (CTG) in labour as a predictor of foetal outcome in high risk pregnancies.Methods: This was a prospective observational study done on 340 high risk patients admitted in labour with a period of gestation of ≥37 weeks. An admission CTG which consists of a 20-minute recording of FHR and uterine contractions was taken and the foetal outcome was correlated with it. The non-parametric Chi-square test was used for statistical calculations and a p valve of <0.05 was considered to designate statistical significance.Results: The admission CTG was reactive in 69.4% of all patients, equivocal in 22.2% and pathological in 8.4% of the 340 recruited patients. A total of 37.5% of the patients were post-dated followed by 20.6% of pregnancy incuded hypertensive patients. The neonatal outcomes in terms of fetal distress, meconium stained liquor, NICU admission were considerably higher in pathological test. The specificity of the test was 53.3%, and the negative predictive was 86.49%.Conclusions: Admission CTG is a simple, useful screening test and serves as a non-invasive tool in forecasting the adverse foetal outcomes in high risk pregnancies.
OPTIMIZATION OF ZAKAT FUND MANAGEMENT IN REGIONAL ZAKAT INSTITUTION
Authors: Widiastuti Tika , Mawardi Imron , Robani Anidah , Rusydiana Aam Slamet 
Published: March 2019

Purpose: The implementation of zakat fund management especially in some zakat institutions is considered not optimum yet. This condition is represented by disparity between potential and actual collection. In Islam, the objective of zakat is not only to collect wealth and keep it idle, instead zakat should become a source of productive fund to fulfill societal needs. Some countries with advanced zakat institutions have developed zakat to become a pillar of economic development. Today, each zakat institution is competing against each other to innovate in zakat fund management. Empowerment in zakat institutions with the appropriate strategies will enhance zakat management and distribution for the betterment of zakat recipients (mustahiq) and the Muslim society at large.
Design/Methodology/Approach: This research is aimed to analyze optimization of management in regional zakat institution with SWOT (strength, weakness, opportunity, threat) analysis approach with IFE-EFE Matrix. Descriptive qualitative analysis is used to explain optimization of fund in zakat institution.
Major Findings:Findings of this research shows that zakat institution should improve their strategy by developing strength and turning threat into opportunities.
Originality/Value: The study provides a guideline for regional zakat institution on how they can enhance their role and efficiency to boost the economic growth for the Islamic community in Indonesia. It may also be instrumental for the government to improve in efficiency and innovative manpower, considerable research and development in optimizing Islamic Gift Economy to enhance economic growth of the Islamic community of Indonesia.
Financing From Demand-Side in Education
Authors: Tasar Haci Huseyin 
Published: March 2019

The belief in the importance of education on economic and social development has resulted in the education expenses being largely covered by the public budget. Countries' approaches to financing education services may vary depending on the tendency to see the education as mixed, complete or private goods and the policies they follow in this direction. In order to fully meet the demands for education, it is of great importance that the available financial resources are spent on the basis of effectively and accountability, as well as the ratio of the financial resources allocated for education. The failure in education is largely attributed to the lack of funding. However, this failure is largely ignored because of the poor use of existing financing, as well as the inadequacy of funding resources. It is an important issue to observe the measures of equality and equity in the distribution of resources related to education and of efficiency and accountability in their spending. Demand-side financing approach in education includes the issues of the freedom of school choice as part of initiating inter-school competitions, giving the 'Education Cheque' or the 'Education Voucher' to student parents and their submitting this cheque or voucher to the board of the school where school stakeholders are also included and where they send their children, within the framework of a protocol, instead of spending the determined money considering the free market conditions or transferring it directly via the education center or district units to the school account for each student studying at each school level. The purpose of this study is to create awareness among education stakeholders and researchers such as decision-makers, managers and teachers regarding the education in by examining the approaches of 'Demand-Side Financing' which is based on parents/ customers' initiative in the use of financial resources allocated from the general budget for education.
Key words: Demand-side financing, education financing, financing
EDITORIAL
Authors: Ozcan Deniz 
Published: March 2019

Dear Readers,
It is the great honor for us to publish Volume 9, Issue 1 of Contemporary Educational Researches Journal (CERJ). The journal welcomes original empirical investigations and comprehensive literature review articles focusing on educational issues. The journal is an international peer-refereed journal that promotes the researches in the field of contemporary teaching and learning approaches and theories.
A total number of seventeen (17) manuscripts were submitted for this issue and each paper has been subjected to double-blind peer review process by the reviewers specialized in the related field. At the end of the review process, a total number of six (6) high quality research papers were selected and accepted for publication.

Aim of this issue is to give the researchers an opportunity to share the results of their academic studies. There are different research topics discussed in the articles.
The topics of the next issue will be different. You can make sure that we will be trying to serve you with our journal with a rich knowledge in which different kinds of topics are discussed in 2019 Volume.
I would like to present many thanks to all the contributors who helped to publish this issue.
Best regards,
Peran Suami dalam Perawatan Kehamilan Istri di Kelurahan Mulyorejo
Authors: Hasanah Imroatul , Fitriyah Nurul 
Published: March 2019

National health development strategy has resulted in improved public health status. One of indicators public health is Maternal Mortality Rate (MMR). Maternal Mortality Rate is a health problem that still many still occur in Indonesia. One factor contributing to high incidence of maternal mortality is lack of antenatal care attention. Antenatal care is an important and mandatory thing done by mother during pregnancy because it can maintain the health of mother and fetus until the birth process. Antenatal care can identify the risk of complications experienced by the mother during pregnancy. Participation of antenatal care not only from wife, but participation of pregnancy care can also be from support of the closest person is husband. Husband role is needed in the care of pregnancy because wife needs a lot of biological and psychological support. Purpose of research is to know characteristics husband to antenatal care in Mulyorejo. Type of research is descriptive with cross sectional using qualitative method. Techniques data collection using questionnaires with the sample number of respondents is 20 husbands who have pregnant wives. Respondent is taken from Mulyorejo Health Center data. Analysis Method with descriptive statistics by displaying the frequency in the form of tables showing the categories of characteristics husband. This study lasted for one month in October to November 2017. The results showed that characteristics of husbands in antenatal care in Mulyorejo is sufficient category. Knowledge of husband is 14 people (70%), husband attitude is 10 people (50%), and husband behavior is 13 people (65%).
Hubungan Kepercayaan dan Tradisi Keluarga pada Ibu Menyusui dengan Pemberian ASI Eksklusif di Kelurahan Sidotopo, Semampir, Jawa Timur
Authors: Setyaningsih Fifin Triana Enita , Farapti Farapti 
Published: March 2019

Exclusive breastfeeding is one effort made to suppress infant mortality rate. The failure of exclusive breastfeeding practices is closely related to the behavior of breastfeeding. Social culture brings about traditions and beliefs that are often used as guidelines for behavior in the community. Belief has formed into a thing that is beliefed and will be the basis for a person to behave. Tradition is obtained through generations and become individual habits. The purpose of this study is to assess the relationship between exclusive breastfeeding and belief and tradition.This is an analytic research with cross sectional approach. Random sampling technique was used. The population was all breastfeeding mothers who had babies aged 6-12months. The sample obtained were 57respondents. The variables studied were breast feeding mothers’ beliefs and traditions on exclusive breastfeeding. Beliefs about giving complimentary foods to infants and the breastfeeding-related traditions in the community were associated with the implementation of exclusive breastfeeding. Data analysis showed that there was a significant relationship between belief (p value = 0,045) and tradition (p value = 0,019) with exclusive breastfeeding in RW XI of Kelurahan Sidotopo. In conclusion, there is a relationship between belief and tradition in society with practice of exclusive breastfeeding. It is recommended that all sectors address belief and traditions in the effort to support exclusive breastfeeding programs.
Pencapaian Kepentingan Korea Selatan melalui Diplomasi Publik Korean Wave
Authors: Trisni Sofia , Isnarti Rika , Sinulingga Anita Afriani , Ferdian Ferdian 
Published: March 2019

Diplomasi publik merupakan instrumen pencapaian kepentingan negara yang populer digunakan, dimana Republic of Korea merupakan salah satu contoh negara yang menggunakan diplomasi publik dengan Korean wave menjadi salah satu medianya. Diplomasi publik Korean wave meraih kesuksesannya di Indonesia secara umum dan kota Padang secara khusus. Tulisan ini bertujuan untuk mendeskripsikan pencapaian kepentingan negara melalui pelaksanaan diplomasi publik yang melibatkan banyak aktor swasta/private. Penulis menggunakan metode survei ke sepuluh universitas yang ada di kota Padang untuk mengetahui pencapaian kepentingan negara ini di kota Padang. Tulisan ini menemukan bahwa walaupun diplomasi publik ini berhasil dalam meningkatkan popularitas Republic of Korea, tetapi kepentingan yang ingin dicapai seperti tersosialisasikannya kebijakan pemerintah dan penciptaan image RoK yang cinta damai dan attractive belum berhasil tercapai sepenuhnya, karena ketertarikan kepada budaya populer yang ditawarkan ternyata tidak berhasil untuk menarik pemuda kota Padang untuk lebih lanjut mempelajari kebijakan-kebijakan pemerintah dan membangun image yang diinginkan oleh pemerintah. Kata kunci : Diplomasi Publik, Korean wave, image, budaya populer, Padang
An Elevated High-Density Lipoprotein Cholesterol Levels Is Associated with Favorable Outcomes of Patients with Small-Artery Occlusion
Authors: Ruixiao Hao , Peipei Liu , Yajing Wang , Wu Jialing 
Published: March 2019

Abstract
Background: The relationship between high-density lipoprotein (HDL) cholesterol and small-artery occlusion (SAO) is not well understood.
Methods: A total of 3067 consecutive patients with SAO were recruited from Tianjin Huanhu Hospital between January 01, 2008, and December 31, 2015. HDL values at admission were classified into four groups according to quartiles (<0.92, 0.92–1.08, 1.08–1.28, and ≥1.28). Patients were followed up to 12 months after stroke. Prognoses, represented by modified Rankin scale (mRS), were estimated via HDL quartiles upon admission utilizing multivariate logistic regression analysis. Meanwhile, we conducted additional subgroup analyses to investigate associations according to age.
Results: Among 3067 patients, 2284(74.5%) were classified as having favorable outcomes, 783(25.5%) had a composite of poor outcomes,recurrent stroke, myocardial infarction or vascular death within 12 months. After adjustment for possible confounders, HDL levels in the two highest quartiles (1.08–1.28 and ≥1.28) were correlated with the 12-month primary outcome of patients with SAO (1.08–1.28 , 0.587; 95% CI,0.394-0.873; P = 0.009; ≥1.28, 0.448; 95% CI, 0.291-0.688; P < 0.001). However, a direct correlation was found in patients aged 45–75 years (1.08–1.28, P = 0.033; ≥1.28, P = 0.001).Similar to the primary outcome,a direct correlation was also found in patients aged 45–75 years with a 12-month secondary outcomes(≥1.28 mmol/L, p = 0.001).
Conclusions: An elevated HDL cholesterol level in patients with SAO is an independent predictor of a favorable prognosis 12 months after SAO. However, the association was only present in patients aged 45–75 years.
Keywords: High-Density Lipoprotein Cholesterol, Stroke, Outcome, Small-Artery Occlusion.
Application of roughing filter to pre-treat 1,000 NTU raw water for slow sand filter
Authors: Hashimoto Yuichi , Takashima Hiroshi , Jayamohan Somasundaram 
Published: March 2019

Abstract
It was confirmed experimentally that a Roughing Filter (RF) is effective as a pre-treatment system for Slow Sand Filter (SSF) with coagulant dosing and mixing with raw water. This RF system can pre-treat high turbidity raw water (1,000 NTU) to generate low turbidity (10 NTU) pre-treated water for SSF treatment. In the experiment, the types of filter media, height of the filter media, filtration rate and coagulant dosing were varied and the characteristics of each item were evaluated and the design guidelines were formulated. Water Treatment Plants (WTPs) consisting of pre-treatment with RF followed by SSF to treat river water were designed and constructed in Myanmar based on the design guidelines, and the operational performance was confirmed as effective to generate treated water with a turbidity under 5 NTU, which is in compliance with the WHO guideline despite the rather short working period of about one year. Sand scraping of SSF at a frequency of about once in every one to two months was implemented to maintain the design filtration rate.
Therapeutic Prospects in Preeclampsia - A Mini-Review
Authors: Das N.S. , Dheen S.T. , Ling E.A. , Bay B.H. , Srinivasan D.K. 
Published: March 2019

Background:
Preeclapmsia (PE) is characterized by early onset symptoms such as
elevated blood pressure, proteinuria and edema in the pregnant woman, and may result in seizures
in the affected female. Currently, there are no therapeutic drugs available to treat this
condition, but there are interventions to regulate the symptoms based on the gestational period
of the fetus, although the largely favored option is delivery of the fetus and placenta.

Objective:
A search for biomolecules associated with PE was conducted so as to identify diagnostic
markers and therapeutic leads.

Results:
The literature search resulted in the identification of biomolecules such as Corin and
Placental Protein 13 (PP13), among others that are associated with PE. Thereby, giving an
insight into the various mechanistic pathways involved in the causation of PE. However, it is
also evident that PE cannot be solely attributed to any single mechanism but is due to an interplay
of different factors that have led to the development of this disease condition.

Conclusion:
The identified biomarkers would ultimately help in understanding this complex
disease and perhaps lead to the discovery of potential effective molecular targets for clinical
trials, thereby providing a valuable therapeutic option for affected pregnant women.
Synthesis, Structural Characterization, Molecular Modeling and DNA Binding Ability of CoII, NiII, CuII, ZnII, PdII and CdII Complexes of Benzocycloheptenone Thiosemicarbazone Ligand
Authors: El-Ghamry Hoda A. , Gaber Mohamed , Farghaly Thoraya A. 
Published: March 2019

Background & Objective:
Six novel complexes of transition metal namely,
[CoLCl2(H2O)2]0.5H2O, [NiLCl2(H2O)2]0.5H2O, [CuLCl2]0.5H2O, [ZnLCl2], [PdLCl2]H2O and
[CdLCl2]H2O, where L is benzocycloheptenone thiosemicarbazone ligand, have been obtained. The
confirmation of the structures of the obtained metal chelates depends on the different spectral and
physicochemical techniques including CHN analysis, infrared spectra, molar conductivity measurement,
UV-vis, thermogravimetric analysis and magnetic moment. The infrared spectral results ascertained
that the ligand behaved as neutral bidentate connecting the metal centers via N and S atoms of
C=N and C=S groups, respectively.

Methods:
The UV-Vis, molar conductivity and magnetic susceptibility results implied that the geometrical
structures of the metal chelates are octahedral for Co(II) & Ni(II) complexes, tetrahedral for
Zn(II) & Cd(II) complexes and square planar for Cu(II) & Pd(II) complexes which have been confirmed
by molecular modeling studies.

Conclusion:
Moreover, the mode of interaction between some chosen metal complexes towards SSDNA
has been thoughtful by UV-Vis spectra and viscosity measurements. The value of the intrinsic
binding constant (Kb) for the examined compounds has been found to be lower than the binding affinity
of the classical intercalator ethedium bromide. Also, the viscosity measurements of the complexes
proved that they bind to DNA, most likely, by a non-intercalative mode like H-bonding or electrostatic
interactions.