bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying and Prioritizing Clinical Guideline Recommendations Most Relevant to Physical Therapy Practice for Hip and/or Knee Osteoarthritis
Authors: Teo Pek Ling , Hinman Rana S. , Egerton Thorlene , Dziedzic Krysia S. , Bennell Kim L. 
Published: July 2019

Background Physical therapists are key providers of conservative management for hip and/or knee osteoarthritis (OA), yet not all guideline recommendations are tailored to their scope of practice. Objective To identify and prioritize the most important recommendations relevant to physical therapy practice for hip and/or knee OA. Methods International physical therapists (n = 132) were invited to participate in an online modified Delphi survey, followed by a priority-ranking exercise. A total of 63 recommendations were extracted from 2 recent high-quality clinical guidelines. In 3 Delphi rounds, the panel identified those recommendations they considered to be most relevant to physical therapy practice for hip and knee OA. Any new recommendations were ascertained. For a recommendation to be included, at least 70% of respondents had to rate the recommendation as 7 or above on a numeric rating scale (0 is not important and 10 is extremely important). The panel prioritized recommendations that remained after the final round using decision-making software. Results Of 132 therapists from 14 countries, 62 completed round 1, 52 completed round 2, 45 completed round 3, and 35 completed the priority-ranking exercise. From an initial list of 70 potential recommendations (including 7 new recommendations), 30 were included in the priority-ranking exercise. The top recommendations were related to providing education and prescribing exercise and weight loss as core treatments, followed by individualized OA assessment and treatment and communication strategies. Conclusion This study identified and ranked the most important recommendations relevant to physical therapy practice for hip and/or knee OA. J Orthop Sports Phys Ther 2019;49(7):501–512. doi:10.2519/jospt.2019.8676
Effects of Covertly Measured Home Exercise Adherence on Patient Outcomes Among Older Adults With Chronic Knee Pain
Authors: Nicolson Philippa J.A. , Hinman Rana S. , Wrigley Tim V. , Stratford Paul W. , Bennell Kim L. 
Published: July 2019

Background Assessment of home exercise adherence and the degree to which adherence influences changes in patient outcomes is limited by the use of self-reported measures. Objectives To determine the relationship between adherence to a home strengthening program, covertly measured by accelerometers in ankle cuff weights, and changes in self-reported pain, physical function, and knee extensor strength among people with chronic knee pain. Methods This is a secondary analysis of data from a clinical measurement study in 54 adults, aged 45 years or older, with chronic knee pain who completed a 12-week, home-based quadriceps-strengthening program. A triaxial accelerometer was concealed in the ankle cuff weight used for exercises to assess exercise adherence. Associations between exercise adherence and changes in pain and function (measured using the Western Ontario and McMaster Universities Osteoarthritis Index) and peak isometric knee extensor strength were examined using mixed-effects and linear regression models and fractional polynomials. Results Exercise adherence declined from a median of 90% (interquartile range, 70%–100%) in weeks 0 to 2 to 65% (interquartile range, 25%–90%) in weeks 10 to 12. Significant improvements were observed in knee pain (mean change, −3.2 units; 95% confidence interval [CI]: −2.4, −3.9 units), function (mean change, −10.1 units; 95% CI: −7.8, −12.4 units), and knee extensor strength (mean change, 0.34 Nm/kg; 95% CI: 0.26, 0.42 Nm/kg) across the group over the same period. Exercise adherence was not associated with changes in pain, function, and knee extensor strength over 2-week periods or over the entire 12 weeks. Conclusion Covertly measured adherence to a home strengthening program was not associated with changes in patient outcomes. These findings challenge the notion that greater exercise adherence leads to greater improvement in patient outcomes during a short-term intervention. J Orthop Sports Phys Ther 2019;49(7):548–556. doi:10.2519/jospt.2019.8843
LEVELS OF DIABETES BLOOD SUGAR WITH TYPE OF CATARACT
Authors: Lestari Indah , Fifiyahpuahsari Fifiyahpuahsari 
Published: July 2019

Diabetes mellitus was a disease with macro and micro risk of angiopathy, which includes the impact of causing cataracts. Diabetic patients with high sugar levels have a greater chance of developing cataracts at a younger age and certain tendencies towards cataract type. The aim of the study was to analyze the correlation between diabetes blood sugar levels and cataract type. The research design was correlation analysis with Cross-Sectional approach. Samples in the study were some cataract patients who had a history of diabetes mellitus in Surabaya Undaan Eye Hospital as many as 125 people, it was taken using consecutive sampling technique, and fulfilling the criteria of the study (age range 45 - 65 years, have complete medical records related to the continuity of sugar examination results in blood, the incidence of cataracts is not caused by congenital cataracts, juveniles, due to trauma, chemical exposure to UV radiation). Independent variable was the blood sugar level of Diabetes mellitus and the Dependent variable was cataract type. The instruments used were laboratory tests related to blood sugar levels, and medical diagnosis related to cataract type. Data were analyzed by Spearman rho, with a significant value <0.05. The results showed a close association between diabetes and cataracts, where as many as 47.2% with high blood sugar levels, 40% with nuclear cataract type and from 59 respondents with high blood sugar levels 26 people experienced nuclear cataract type, with rho value = 0.001. The mechanism of glucose toxicity in Diabetes Mellitus which causes cataracts can go through three paths: increased activity of the aldose reductase enzyme which causes the formation of sugar alcohol, sorbitol and galactitol in crystalline lenses; through the non-enzymatic replication process; and at high blood glucose levels a glucose oxidation process will occur which causes oxidative stress conditions. Maintenance of managing blood sugar levels must be a concern for diabetics.

Keywords: Blood Sugar Level, Diabetes Mellitus, Type of Cataract
Cambios en las características físicas y químicas de un suelo después de la incorporación de compost de distinto origen
Authors: Koritschoner Julius José , Rampoldi Edgar Ariel , Hang Susana Beatriz 
Published: July 2019

The effect of differents compost, obtained through the same composting methodology, was evaluated on the soil after two years of application. On a Typic Haplustoll, 40 Mg ha-1 of each compost was applied to the soil, forming the following treatments: CBIO with addition of biosolids compost, CF with addition of cattle-manure compost, CG with addition of poultry-manure compost, CROU with addition of organic urban waste compost. One treatment with inorganic fertilizer (FI) and an untreated or control soil (C0) was also included. Soil pH was slightly affected by compost addition according to compost characteristics. CROU and CBIO increasing and decreasing the pH, respectively (R2= 0.98). Soil organic matter of CG treatment showed changes in content of carbon fractions, without increment in total organic carbon (COT). The Cfracción>53?m increased in 85 % and alcali-extractable C increased in 24 % in CG respect to C0. Finally, concentration of CuM and ZnM increased in CROU. Our results show that a single incorporation of compost can modify soil properties due to the multiple materials composted. It should be done a monitoring to soil conditions to identify early trends and avoid negative environmental effects.
Knowledge regarding breast self-examination among the women in Nepal: A meta-analysis
Authors: Sathian Brijesh , Asim Mohammad , Mekkodathil Ahammed , James Sruthi , Mancha Angela , Ghosh Arnab 
Published: July 2019

Background: Screening interventions for the early diagnosis of breast cancer are associated with better clinical outcomes. Developing nations such as Nepal reportedly have lesser frequency of female university graduates (UGs) and therefore public awareness and education remains central in the early diagnosis. The current meta-analysis was aimed to assess the knowledge about breast self-examination (BSE) among women of Nepal.
Materials and Methods: We have conducted the literature search using electronic databases such as PubMed, MEDLINE, Cochrane library and Google scholar. The search terms utilized were “breast self-examination”; “knowledge”, “awareness”; and “attitude” in various combinations AND “Nepal” in the title or abstract. Additional searches were conducted with the help of cross references quoted in the selected studies and review articles. Data were retrieved using excel sheets which were pilot tested. Data were independently abstracted by the four authors using a standardized data collection form. Findings from the various studies were pooled together for the sake of analysis, if appropriate.
Results: The search yielded 36 articles; 27 duplicates and review articles were excluded and a further 4 articles not relevant were excluded. Finally, 5 original studies met the inclusion criteria. Total pooled sample size for assessing knowledge was 1910. The overall pooled knowledge about breast self-examination was found to be 27% with a 95% CI [26-31].
Conclusion: The pooled estimates demonstrated that the overall knowledge of breast self-examination was inadequate among women in Nepal. Therefore, prompt capacity building measures are warranted to enhance the public awareness towards BSE.
La homoparentalidad: un interés vigente de la investigación latinoamericana
Authors: Ahammed Bolaños Bino , Colorado Rocio Milena , Quintero Javier Fernando , Mesa Lorena del Pilar 
Published: July 2019

Como profesionales estamos inmersos en las discusiones de coyuntura política y en América Latina las familias homoparentales han comenzado poco a poco a ser el foco central de las investigaciones científicas desde diferentes disciplinas, por lo anterior se identificó la necesidad de conocer la literatura sobre familias homoparentales. Objetivo: determinar las temáticas principales reportadas por investigadores latinoamericanos durante los últimos cinco años. Metodología: revisión integrativa de la literatura científica (revisión crítica) en bases de datos electrónicas. Se aplicaron 6 criterios de selección para una masa documental de 83 artículos, se priorizaron 21 que fueron leídos a profundidad. Resultados: los intereses más recurrentes en las investigaciones se enfocan en establecer la capacidad de las parejas homosexuales para ser madres/padres, y determinar si son familias que cuentan con una red social débil o fuerte, particularidades de su día a día, detección de vulneración de derechos y las implicaciones negativas o positivas que pueden darse en el desarrollo de los niños y niñas. Conclusión: al parecer no hay afectaciones negativas en su desarrollo psicológico, su desempeño académico no tiene diferencias particulares con sus compañeros. En contraposición, se ha encontrado que son más tolerantes con las diferencias, más permisivos con el establecimiento de roles de género, tienen un menor nivel de prejuicios, manejan un alto nivel de resiliencia y en general distan de un sistema heteronormativo dominante.
Mujeres fumadoras y su asociación con atipia del cérvix uterino en Las Tunas, Cuba
Authors: Pérez Castillo Raydel , Cordero González Yoanne , Del Río Boullón Tania 
Published: July 2019

Introducción: Las atipias del cérvix uterino se definen como alteraciones del tamaño, forma y núcleo de las células epiteliales. El tabaquismo se asocia a la persistencia de la infección del virus del papiloma humano y a la progresión al cáncer cervicouterino. El objetivo es identificar la correlación entre el tabaquismo y las atipias celulares de cérvix uterino. Métodos: Se realizó un estudio descriptivo, correlacional, retrospectivo en 235 mujeres con diagnósticos de atipias celulares por test de Papanicolaou desde de enero de 2013 a marzo de 2019. Se analizaron las variables edad, primeras relaciones sexuales, resultados citológicos y consumo de tabaco. Se determinó la asociación estadística por la prueba de Chi cuadrado y Coeficiente de Spearman para un nivel de significación de (p<0,05). Resultados: La media de edades fue de 37,5 ±10,4 con primeras relaciones sexuales a los 16±1,9 años. Predominaron las atipias de bajo grado NIC-1 (n=115; 48,94%) y NIC-2 (n=76; 32,34%). Las mujeres fumadoras (n=82; 34,89%) como promedio presentaron un consumo diario de 12,60 cigarrillos, con un historial de 11,3 años y 7,8 cajetillas anuales. La mayor correlación estuvo entre los tipos de lesiones y el índice tabáquico (Rho Spearman 0,84; p<0,0001). Conclusión: Mujeres en edad fértil con inicio precoz de sus relaciones sexuales son más propensas a presentar atipias del cérvix. En las mujeres ha aumentado la adicción al tabaco y el diagnóstico de las atipias del cérvix en los últimos años. En mujeres fumadoras existe un ciclo gradual con tendencia a lesiones de alto grado. La severidad de las lesiones presenta correlación y proporcionalidad directa ante el consumo anual de cigarrillos.
A Social Impact Bond (SIB) : A Shariah Appraisal
Authors: Ahmad Mahadi Umar , Bambale Yahaya Yunusa , Adam Zain Mahamad Ibrahim 
Published: July 2019

Social Impact Bond (SIB) is a funding mechanism for social projects whereby the payment for the projects is anchored on meeting the outcome metrics, otherwise the investors risk losing their money. The mechanism emerged since 2010 in the United Kingdom and has quickly spread to other parts of the world. In the past, there has not been any popular fatwā on this mechanism from a Sharīʿah point of view. Therefore, this article will examine the funding and payment arrangement and then conduct takyif fiqhi (jurisprudential adaptation) to ascertain the degree of Sharīʿah compliance and determine the most appropriate Islamic contract most suitable under the arrangement. The article adopts qualitative method of research by making in-depth analysis of Islamic contracts including the primary and secondary sources of Islamic law. It also relied on literature on SIB from conventional point of view and internet materials. Major findings of the research show that SIB, whilst its pay-for-success mechanism does not contain ribā, it contains excessive gharar. The excessive gharar, however, was found ineffective to void al-jaʿālah-based SIB and hibah li thawāb which is the second contract similar to SIB. This is because of hājah and element of gratuity respectively.
What Makes a Law “Islamic”? A Preliminary Study on the Islamicity of Laws in Malaysia
Authors: Wan Muhammad Ramizah 
Published: July 2019

There exists a good deal of misunderstanding regarding laws in general. Some laws are categorised as civil or common laws even though their contents are Islamic while others are labelled Islamic but they fail to meet the standards required by Islamic law. This article discusses the characteristics, which make a law, “Islamic”. Based on a content analysis of the revealed sources, the opinion of the majority of Muslim scholars, and the relevant court cases, this study argues that a law does not become Islamic by merely claiming it to have been derived from or somehow related to the divine revelation. It is true that for any law to be Islamic, it must indeed be based upon the divine revelation, and supported by Muslim jurists. Nevertheless, it must also simultaneously be promoting justice for everyone, irrespective of race, religion, gender, social, economic or political status. The law must also be of benefit to all mankind and not only to the Muslims. Finally, the law must fulfil the requirements of MaqāÎid al-sharÊ‘ah (objectives of the law). Judged as such, most of the Malaysian laws may be considered to be Islamic, by nature. These aspects have not been given due attention by many scholars, which leads either to the condemnation of all laws in Malaysia as secular or as un-Islamic. This fact alone justifies the need for a study to provide guidelines to judge the Islamicity of a certain law, which is done herein.
EFEKTIFITAS ANTIBAKTERI Staphylococcus aureus EKSTRAK RIMPANG TEMU HITAM (CURCUMA AERUGINOSA ROXB) DARI KECAMATAN KENDAL
Authors: Ariyanti Ariyanti 
Published: July 2019

ABSTRAK
Rimpang temu hitam merupakan tanaman dengan khasiat sebagai antibakteri.Penelitian ini bertujuan untuk mengetahui efektifitas antibakteri ekstrak rimpang temu hitam terhadap bakteri staphylococcus aureus.Metode yang digunakan dalam penelitian ini adalah metode kualitatif dan metode difusi sumuran. Uji efektifitas antibakteri terbentuk zona bening pada media yang diukur menggunakan jangka sorong.
Hasil penelitian menunjukan bahwa temu hitam dapat menghambat bakteri staphylococcus aureus. Rata – rata zona bening yang diukur dengan jangka sorong pada konsentrasi 15% yaitu 7,10 mm, konsentrasi 20% yaitu 12,21 mm dan konsentrasi 25% yaitu 15,19 mm. Hasil analisa statistik uji mann whitney didapatkan nilai signifikasi antara masing – masing konsentrasi yaitu 0,000 dimana nilai tersebut < 0,05 maka H0 ditolak, artinya ada perbedaan rata – rata antara konsentrasi tersebut. Hasil analisa statistik uji t-test antara konsentrasi 20% dan konsentrasi 25% didapatkan nilai signifikasi 0,103 dimana nilai tersebut > 0,05, maka H0 diterima, artinya tidak ada perbedaan rata – rata antara konsentrasi tersebut. Hal tersebut menunjukan bahwa konsentrasi efektif yang memiliki efektifitas antibakteri adalah 20%.

Kata kunci :Ekstrak rimpang temu hitam, Efektifitas Antibakteri,Staphylococcus aureus

ABSTRACT
Curcuma aeruginosa is a plant with antibacterial properties. This research is to know the antibacterial efectifity of Curcuma aeruginosa extract against staphylococcus aureus bacteria. Method used in this research is qualitative method and diffusion method of wells. The antibacterial activity test is formed of clear zone on the medium measured using the sliding term.The results showed that the Curcuma aeruginosa can inhibit staphylococcus aureus bacteria. The average clear zone measured by the sliding term at 15% concentration is 7.10 mm, the concentration of 20% is 12.21 mm and the concentration of 25% is 15.19 mm. The result of statistical analysis of mann whitney test showed significance value between each concentration that is 0.000 where in <0.05 then H0 rejected, there is average difference between the concentration. Test statistic t test between concentration 20% and concentration of 25% got significance value 0,103 where with this> 0,05, then H0 accepted, there is no difference mean between the concentration. This suggests that an effective concentration having antibacterial efectifity is 20%. Keywords: Curcuma aeruginosa extract, Efectifity Antibacterial, Staphylococcus aureus
Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas
Authors: Buchynska L.G. , Brieiev O.V. , Iurchenko N.P. 
Published: July 2019

Summary. Aim: To analyze copy number variations of HER-2/neu, c-MYC and CCNE1 oncogenes and their protein expression in endometrioid endometrial carcinomas in relation to the degree of tumor progression and presence of a family history of cancer in cancer patients. Materials and Methods: The study was conducted on endometrial cancer (EC) samples from 68 patients with I–II FIGO stages of disease. Copy number analysis of HER-2/neu, c-MYC and CCNE1 genes was performed by quantitative PCR. Protein expression was analyzed using immunohistochemistry. Results: Assessment of copy number variations of HER-2/neu, c-MYC and CCNE1 genes revealed their amplification in the tumors of 18.8, 25.0 and 14.3% of EC patients, respectively. High expression of corresponding proteins was detected in 14.6, 23.5 and 65.6% of patients, respectively. It was established that HER-2/neu gene amplification is more common in the group of tumors of low differentiation grade than in moderate grade EC (35.7 and 5.5% of cases, respectively, p < 0.05). Also, high expression of c-Myc protein was more frequently observed in low differentiated tumors compared to the moderately differentiated EC (36.6 and 13.2% of cases, respectively, p < 0.05). Expression of HER-2/neu and cyclin E proteins was found to be dependent on the depth of tumor invasion into the myometrium. High expression of HER-2/neu protein was observed in 25.0 and 4.1% of EC patients with tumor invasion > ½ and < ½ of the myometrium, respectively, and cyclin E — in 86.7 and 46.6% of cases, respectively, p < 0.05. It was shown that among patients with a family history of cancer, a larger proportion of cases with high expression of c-Myc protein was observed compared to the group of patients with sporadic tumors (43.8 and 17.3%, respectively; p < 0.05). Conclusions: Amplification of HER-2/neu gene, along with high expression of c-Myc, HER-2/neu and cyclin E proteins, are associated with such indices of tumor progression as a low differentiation grade and deep myometrial invasion, suggesting the potential possibility of including these markers in the panel for determining the molecular EC subtype associated with an aggressive course of the disease. In a certain category of EC patients, there is a relationship between a family history of cancer and high expression of c-Myc protein.
KEEFEKTIFAN PELAKSANAAN PENANGGULANGAN BENCANA DI KABUPATEN ACEH BARAT DALAM PERSPEKTIF HUKUM BENCANA
Authors: Handoyo Budi 
Published: July 2019

Article 4 of West Aceh Qanun No.13 of 2011 about Disaster Management says that the implementation of disaster management aims to provide protection to the public from the threat of disaster, aligning the legislation that already exists, ensure the implementation of disaster management in a planned, integrated, coordinated, and comprehensive, appreciate the local culture, building and public participation. However, in practice the function structure, substance and legal culture in disaster management has not been effective because it is still faced with mIany obstacles that affect the effectiveness.
The implementation of disaster management in Aceh Barat District have not been fully implemented yet effective considering the functioning of the three elements of the legal system became a major element of disaster management.In fact, if all three elements of a functioning legal system with another implementation of disaster management can be effective as effective as can be seen in the alignment of the substance elements Qanun No.13 of 2012 on the disaster management with other legislation.Effective functioning legal culture provide an understanding of the legal community as integration through community participation and socialization legislation implemented through institutional legal authorities.Factors which become obstacles in the disaster relief efforts in Aceh Barat District include inadequate institutional performance and disaster management officials, the low awareness of disaster risk and low understanding of both the law and public administration officials to the disaster rules
Effect of Solanum melongena peel extract in the treatment of arsenical keratosis
Authors: Sarah Quazi Sahely , Misbahuddin Mir 
Published: July 2019

This study was conducted to examine the effect of the ointment containing Solanum melongena peel extract in the treatment of arsenical keratosis. In total, 23 patients were enrolled on the basis of inclusion and exclusion criteria. The ointment was given to each patient and advised him/her to apply to the site of lesion twice daily for 12 weeks without any gap. The size of the lesion and its photograph were collected before and at the end of the study. The mean (± SD) diameter of the lesion was 3.9 ± 2.1 cm which reduced to 1.8 ± 1.3 cm (reduction 54%). The results were statistically significant. In conclusion, S. melongena peel extract is found to be effective in the treatment of arsenical keratosis.