bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elucidating the Molecular Mechanisms and Comprehensive Effects of Sludge‐Derived Plant Biostimulants on Crop Growth: Insights from Metabolomic Analysis
Authors: Hua Yu , Chen Shuxian , Tong Tong , Li Xiaoou , Ji Rongting , Xu Qiujin , Zhang Yue , Dai Xiaohu 
Published: November 2024

AbstractThe utilization of urban waste for land management plays a crucial role in reshaping material flows between human activities and the environment. Sewage sludge alkaline thermal hydrolysis (ATH) produces sludge‐derived plant biostimulants (SPB), which have garnered attention due to the presence of indole‐3‐acetic acid. However, there remains a gap in understanding SPB's molecular‐level effects and its comprehensive impact on crops throughout their growth cycle. In this study, non‐targeted and targeted metabolomic approaches are employed to analyze 51 plant hormones and 1,177 metabolites, revealing novel insights. The findings demonstrate that low concentrations of SPB exerted multiple beneficial effects on rice roots, leaves, and the root‐soil system, facilitating rapid cell division and enhancing antioxidant defense mechanisms. These results provide a vital foundation for understanding ATH metabolic pathways and advocating for widespread SPB application, offering significant implications for sustainable land management.
CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway
Authors: Chen Cheng , Zheng Xu , Wang Cheng , Zhou HaiChao , Zhang Yi , Ye TianBao , Yang YunFeng 
Published: November 2024

AbstractTendinopathy poses a formidable challenge due to the inherent limitations of tendon regenerative capabilities post‐injury. At present, effective curative approaches for tendinopathy are still lacking. Collagen triple helix repeat‐containing 1 (CTHRC1) is an extracellular matrix protein with significant roles in both physiological and pathological processes. The present study aims to investigate the function and underlying mechanism of CTHRC1 in tendinopathy. In this study, CTHRC1 is identified as a potential effector in promoting tendon regeneration through multi‐proteomic analysis of Achilles tendon tissues in mice. In vitro, CTHRC1 enhances the proliferation, migration, and tenogenic differentiation of tendon stem/progenitor cell (TSPC). In vivo, CTHRC1 deletion impairs tendon healing, while its overexpression reverses the detrimental effects caused by CTHRC1 deficiency. Mechanistically, proteomics on TSPC stimulated with recombinant CTHRC1 reveal that CTHRC1 activates the mitogen‐activated protein kinase (MAPK) signaling pathway via binding to epidermal growth factor receptor (EGFR), which in turn promotes the proliferative, migrative, and tenogenic capacities of TSPC to attenuate Achilles tendinopathy. Conversely, inhibiting EGFR reverses the tendon‐healing effect of CRHRC1. The study demonstrates that CTHRC1 can promote the proliferative, migrative, and tenogenic capacities of TSPC, ultimately facilitating tendon healing through activating the EGFR/MAPK signaling pathway. CTHRC1 holds promise as a potential intervention for tendinopathy.
Organic‐Inorganic Hybrid Solid Composite Electrolytes for High Energy Density Lithium Batteries: Combining Manufacturability, Conductivity, and Stability
Authors: De Sloovere Dries , Mercken Jonas , D'Haen Jan , Derveaux Elien , Adriaensens Peter , Vereecken Philippe M. , Van Bael Marlies K. , Hardy An 
Published: November 2024

AbstractThe deployment of solid and quasi‐solid electrolytes in lithium metal batteries is envisioned to push their energy densities to even higher levels, in addition to providing enhanced safety. This article discusses a set of hybrid solid composite electrolytes which combine functional properties with electrode compatibility and manufacturability. Their anodic stability >5 V versus Li+/Li and compatibility with lithium metal stem from the incorporated ionic liquid electrolyte, whereas the organic‐inorganic hybrid host structure boosts their conductivity up to 2.7 mS cm−1 at room temperature. The absence of strong acids enables compatibility with porous NMC811 electrodes. Liquid precursor solutions can be readily impregnated into porous electrodes, facilitating cell assembly. Electrolytes containing TFSI− as the only anion have a superior compatibility toward high‐voltage positive electrode materials, whereas electrolytes containing both FSI− and TFSI− have a better compatibility toward lithium metal. Using the former as catholyte and the latter as anolyte, NMC811/Li coin cells retain up to 100% of their initial capacity after 100 cycles (0.2 C, 3.0–4.4 V vs Li+/Li). Because of their unprecedented combination of functional properties, electrode compatibility, and manufacturability, these hybrid solid composite electrolytes are potential candidates for the further development of lithium metal battery technology.
Rational Design of Biocompatible Ir(III) Photosensitizer to Overcome Drug‐Resistant Cancer via Oxidative Autophagy Inhibition
Authors: Park Mingyu , Nam Jung Seung , Kim Taehyun , Yoon Gwangsu , Kim Seoyoon , Lee Chaiheon , Lee Chae Gyu , Park Sungjin , Bejoymohandas Kochan S. , Yang Jihyeon , Kwon Yoon Hee , Lee Yoo Jin , Seo Jeong Kon , Min Duyoung , Park Taiho , Kwon Tae‐Hyuk 
Published: November 2024

AbstractAutophagy is a crucial quality control mechanism that degrades damaged cellular components through lysosomal fusion with autophagosomes. However, elevated autophagy levels can promote drug resistance in cancer cells, enhancing their survival. Downregulation of autophagy through oxidative stress is a clinically promising strategy to counteract drug resistance, yet precise control of oxidative stress in autophagic proteins remains challenging. Here, a molecular design strategy of biocompatible neutral Ir(III) photosensitizers is demonstrated, B2 and B4, for precise reactive oxygen species (ROS) control at lysosomes to inhibit autophagy. The underlying molecular mechanisms for the biocompatibility and lysosome selectivity of Ir(III) complexes are explored by comparing B2 with the cationic or the non‐lysosome‐targeting analogs. Also, the biological mechanisms for autophagy inhibition via lysosomal oxidation are explored. Proteome analyses reveal significant oxidation of proteins essential for autophagy, including lysosomal and fusion‐mediator proteins. These findings are verified in vitro, using mass spectrometry, live cell imaging, and a model SNARE complex. The anti‐tumor efficacy of the precise lysosomal oxidation strategy is further validated in vivo with B4, engineered for red light absorbance. This study is expected to inspire the therapeutic use of spatiotemporal ROS control for sophisticated modulation of autophagy.
Nanometer‐Scale 1D Negative Differential Resistance Channels in Van Der Waals Layers
Authors: Yao Qirong , Park Jae Whan , Won Choongjae , Cheong Sang‐Wook , Yeom Han Woong 
Published: November 2024

AbstractNegative differential resistance (NDR) is the key feature of resonant tunneling diodes exploited for high‐frequency and low‐power devices and recent studies have focused on NDR in van der Waals heterostructures and nanoscale materials. Here, strong NDR confined along a 1‐nm‐wide 1D channel within a van der Waals layer 1T‐TaS2 is reported. Using scanning tunneling microscopy, a double 1D NDR channel formed along the sides of a charge–density‐wave domain wall of 1T‐TaS2 is found. The density functional theory calculation elucidates that the strong local band‐bending at the domain wall and the interlayer orbital overlap cooperate to bring about 1D NDR channels. Furthermore, the NDR is well controlled by changing the tunneling junction distance. This result would be important for nanoscale device applications based on strong nonlinear resistance within van der Waals material architectures.
Chimeric SFT2D2‐TBX19 Promotes Prostate Cancer Progression by Encoding TBX19‐202 Protein and Stabilizing Mitochondrial ATP Synthase through ATP5F1A Phosphorylation
Authors: Hu Chenxi , Zheng Zaosong , Pang Shiyu , Zhu Yuanchao , Jie Jirong , Lai Zhuocheng , Zeng Xiangbo , Xiao Yongyuan , Chen Zhifeng , Zhao Jingjing , Du Yuejun , Li Fei , Wang Qiong , Tan Wanlong 
Published: November 2024

AbstractSpecific chimeric RNAs and their products are consistently regarded as ideal tumor diagnostic markers and therapeutic targets. Chimeric RNAs can mediate tumor cell plasticity, neuroendocrine processes, polarization of tumor‐associated macrophages, and resistance to chemotherapy and immunotherapy. However, the discovery of chimeric RNAs in prostate cancer is still in its early stages. This study identifies the chimeric SFT2D2‐TBX19 as a novel transcript encoding the TBX19‐202 protein. Both TBX19‐202 and its parental TBX19, which share homologous amino acid sequences, enhance prostate cancer cell proliferation, migration, and invasion. Additionally, SFT2D2‐TBX19 also functions as a lncRNA, interacting with the ATP synthase F1 subunit ATP5F1A, thereby increasing ATP5F1A phosphorylation mediated by TNK2/ACK1, which stabilizes the interaction between ATP5F1A and ATP5F1B. The region spanning 1801‐2400 bp of SFT2D2‐TBX19 and the intermediate structural domain of ATP5F1A are crucial functional areas. This stabilization of ATP5F1A and ATP5F1B enhances mitochondrial ATP synthase activity and ATP production. Even under conditions of mitochondrial vulnerability, SFT2D2‐TBX19 protects mitochondrial structural stability to maintain prostate cancer cell proliferation. This research provides comprehensive evidence that chimeric SFT2D2‐TBX19 promotes prostate cancer progression by encoding the TBX19‐202 protein and stabilizing mitochondrial ATP synthase via ATP5F1A phosphorylation. These findings highlight SFT2D2‐TBX19 as a potential therapeutic target for prostate cancer.
Electron‐Deficient Organic Molecules Based on B←N Unit: A N‐Type Room‐Temperature Chemiresistive Sensors with Moisture Resistance
Authors: Wang Binbin , Xing Yali , Zhang Kewei , Wang Zhong , Xia Yanzhi , Long Xiaojing 
Published: November 2024

AbstractOrganic molecules with tailorable chemical structures, high stability, and solution processability have great potential in the sensing field. Compared with p‐type organic small molecules (OSMs), the electron‐dominated n‐type analogs show superior conductivity when exposed to reducing gases, which can achieve outstanding sensor signal‐to‐noise ratios. However, inadequate humidity resistance at room temperature hinders the development of such molecules. Herein, an A‐D‐π‐D‐A molecular design strategy is proposed based on electron‐deficient B←N units, which results in effective intramolecular charge transport and sensitive responses by extending the π‐conjugation bridge. As a result, the ST‐2BP with A‐D‐π‐D‐A configuration shows a prominent sensitivity of 787 (Ra/Rg) in 20 ppm NH3 at room temperature and an almost initial and stable response under different relative humidity conditions, which is the highest among currently reported OSM sensors. Supported by theoretical calculations and in situ FTIR spectra, it is revealed that B←N units, which function as the active centers mediate the specific ammonia adsorption. This study provides a new understanding of the design of high‐performance room temperature gas sensing materials by decorating B←N units.
Public and participant involvement as a pathway to inclusive dementia research
Authors: Walter Sarah , McArdle RÍona , Largent Emily A. , Edelmayer Rebecca , Sexton Claire , Sandoval Sandra Loyola , Medsger Helen , Meserve Nancy , Samaroo Roland , Sierra Cynthia , Smeitink Marlon M. P. , Gibson Allison , Gregory Sarah , Karamacoska Diana , Leroi Iracema , Molina‐Henry Doris , Suarez‐Gonzalez Aida , Glover Crystal M. 
Published: November 2024

AbstractThe field of Alzheimer's disease and related dementias (ADRD) urgently requires inclusive research to ensure the priorities and outcomes of research apply to those most impacted. We postulate public and participant involvement (PPI) as a pathway to achieving the best science, both in research that informs health and social policy as well as in therapeutic studies to treat and prevent ADRD. This position paper aims to provide dementia researchers with evidence to understand how to apply PPI. We begin by highlighting the disparities experienced by people with dementia, including ageism, stigma of cognitive impairment, and health disparities for minoritized communities. We then provide examples of PPI in ADRD across the research lifecycle, from defining research topics of priority to those impacted by ADRD, through the design, analysis, dissemination, and translation to policy and practice. We also provide recommendations to create and maintain collaboration between researchers and communities through PPI.Highlights
A central premise of public and participant involvement (PPI) is collaborative relationships between researchers and community members.
To build equitable partnerships, researchers must acknowledge and understand the context of research. This includes ageism, the stigma of dementia, and ongoing discrimination for many minoritized communities.
Meaningful partnerships include choice, respect, shared decision making, access, inclusion, and representation. Notably, we recommend that researchers begin partnerships early in the research process and share the impact of PPI on research.
Sex‐Specific Vulnerabilities to Subclinical Vascular Brain Injury in Early Late‐Life: The Framingham Heart Study
Authors: Yau Wai‐Ying Wendy , Scott Matthew R. , Petrea Rodica E. , Buckley Rachel F. , Kojis Daniel , Sperling Reisa A. , Chhatwal Jasmeer P. , Maillard Pauline , Aparicio Hugo J. , Romero Jose Rafael , DeCarli Charles S. , Beiser Alexa S. , Seshadri Sudha 
Published: November 2024

ObjectiveSubclinical vascular brain injury is an increasingly recognized risk factor for stroke and dementia. Despite well‐established sex differences in vascular risk and disease prevalence, the impact of sex on drivers of subclinical vascular brain injury remains unclear, presenting a barrier to developing sex‐specific prevention guidelines. We aimed to establish the extent to which sex moderates associations between vascular risk factors and magnetic resonance imaging (MRI) measures of subclinical brain injury in stroke‐free older adults.MethodsWe leveraged cross‐sectional data from 1,579 stroke‐ and dementia‐free Framingham Heart Study Offspring participants at exam 8 (age 65.7 ± 8.8 years, 53% women). Vascular risks were assessed using components of the Framingham Stroke Risk Profile (FSRP) and diastolic blood pressure (DBP). White matter hyperintensity volume (WMH), total cerebral brain volume (TBV), and covert brain infarcts were quantified using MRI. We examined whether vascular risk factors were associated with MRI measures across the combined cohort, and then determined whether sex modified these associations.ResultsHigher FSRP and specifically systolic blood pressure (SBP) were associated with greater WMH. These associations were stronger in women and remained after adjusting for menopause age and hormone therapy use. By contrast, diabetes and lower DBP were associated with smaller TBV primarily in men. The DBP‐atrophy relationship was only observed in men with declining DBP or prior hypertension.InterpretationOur findings highlight differential vulnerability to the impact of vascular risk factors on white matter health in women and global atrophy in men, supporting the development of sex‐specific guidelines to better preserve vascular brain health in aging. ANN NEUROL 2025;97:460–469
GlutaR: A High‐Performance Fluorescent Protein‐Based Sensor for Spatiotemporal Monitoring of Glutamine Dynamics In Vivo
Authors: Liu Bingjie , Zhao Zijie , Wang Pengcheng , Aihemaiti Kamiran , Zhu Lixin , Wei Qingpeng , Li Wenzhe , Yuan Xia , Wu Jing , Jiang Changtao , Hao Min , Wang Jing 
Published: November 2024

AbstractGlutamine is the most abundant amino acid in human blood and muscle, and is integral to a wide variety of functions in cancer cells. However, the inability to monitor the subcellular distribution of glutamine in real‐time has obscured understanding of glutamine metabolism under physiological and pathological conditions. Here, we report the development of a genetically encoded fluorescent sensor and demonstrate how this GlnBP‐cpYFP fusion “GlutaR sensor” undergoes glutamine‐induced conformational changes reflected in detectable fluorescence responses. Obtained after iterative screening of approximately 1,600 variants, GlutaR exhibits a ratiometric readout, fast response kinetics, and high responsivity (R488/405 of ~1000 %), and we demonstrate its selectivity for monitoring glutamine fluctuations in multiple cell types. Additionally, using digitonin permeabilization of GlutaR HeLa cells, we generated a calibration curve and performed in situ titration to quantify free glutamine concentrations in subcellular compartments (cytosol, nucleus, mitochondria). Subsequently, we applied GlutaR to investigate how chemical and genetic inhibition of glutamine synthetase (GS) and glutaminase (GLS) differentially alter glutamine levels in subcellular compartments. Finally, we demonstrate GlutaR's ability to monitor dynamic glutamine levels in muscle and liver tissues of diabetic mice in vivo. These findings collectively demonstrate GlutaR as a versatile tool for the spatiotemporal characterization of glutamine metabolism in living cells and tissues.
Novel ZnO‐Co3O4‐CuO Nanocomposite Catalyzed Microwave‐Assisted Facile Synthesis of Polyhydroquinoline Derivatives
Authors: Jain Shruti , Jain Shubha , Verma Divya 
Published: November 2024

ABSTRACTA novel ZnO‐Co3O4‐CuO nanocomposite (NC) has been explored as a heterogeneous catalyst for synthesizing a library of polyhydroquinolines (PHQ 1–10) via microwave‐assisted multicomponent reaction of various aromatic aldehydes, ethyl acetoacetate or ethyl cyanoacetate, dimedone, and ammonium acetate at 400 W in polyethylene glycol (10 mL) as a solvent. The NC showed a characteristic weak ferromagnetic behavior with a particle size of 10.3 ± 0.1 nm and surface area of 45.67 m2/g was easily prepared through a straightforward chemical coprecipitation method and was systematically characterized using XRD, FTIR, FESEM, HRTEM, EDS, BET, and VSM. The NC has an agglomerated particle cluster having a nearly spherical shape exhibiting brilliant catalytic performance, over +12.94 mV zeta potential value, hydrodynamic diameter of 267 nm, best dispersion stability, and reusability for up to six runs. This method of synthesizing PHQs has notable advantages of producing higher yields in a shorter reaction time (20 min), using simple, low‐cost catalyst, and microwave irradiation as a non‐conventional energy source. The highest TON of 37.76 and TOF of 113.29 h−1 also indicate that this is the best atom‐efficient and green design for the synthesis of polyhydroquinolines. Some novel polyhydroquinolines were also synthesized with excellent yield.
A Novel Multifunctional Eu (III)‐MOF Luminescence Sensor for Detecting NB, Fe3+, and Cr2O72− With Outstanding Sensitivities and Selectivities
Authors: Li Jiahui , Zhang Shiman , Fan Liming , Yang Yunfeng , Wen Rongmei 
Published: November 2024

ABSTRACTThe bowl‐shaped flexible carboxylic acid zwitterion 1,1′,1″‐(2,4,6‐trimethylbenzene‐1,3,5‐triyl)tris (methylene)‐tris(4‐carboxy‐pyridinium)tribromide (H3LBr3) ligand‐based lanthanide metal–organic framework (Ln‐MOF) was synthesized for the first time under solvothermal conditions. Single crystal X‐ray diffraction analysis indicates that the molecular formula of Ln‐MOF is [EuL2(H2O)4Br3]·2H2O (1). Luminescence sensing experiments demonstrate that 1 shows obvious fluorescence quenching for nitrobenzene (NB), Fe3+, and Cr2O72− with low detection limits of 0.118 μM, 9.098 nM, and 17.409 nM, respectively. 1 can be regarded as a luminescence sensor with multiple functions, displaying high selectivity, wonderful antiinterference ability, outstanding sensitivity, and recyclability to detect NB, Fe3+, and Cr2O72−.
Real Wage Growth in Papua New Guinea Over Three Decades
Authors: Blunch Niels‐Hugo , Davies Martin 
Published: November 2024

ABSTRACTAs a key determinant of household welfare, workersʼ real wages matter. Limited by small and infrequent surveys, the study of real wages in Papua New Guinea (PNG) has until now been constrained by a paucity of data. Using a novel dataset, we construct the first longitudinal series of wages for (to a close approximation) the population of formal private sector workers in PNG over a 3 decades span from 1999 to 2018. We examine real wage growth for the formal private sector in PNG over a 20‐year period using panel regression. Among the main findings are that conditional real wage growth has averaged about 4.5%. Also, real wage developments closely mirror the bust‐boom‐bust episodes of the macroeconomic cycle. Further, conditional real wage growth in the agricultural sector lagged that in services, industry, and mining with agriculture hardest hit during busts and lagging during the boom and mining the winner. Men experience higher conditional real wage growth during booms but also bear the majority of the decrease during busts. Finally, we establish the strong co‐movement of the real exchange rate (RER) and the conditional real wage, providing support for the RER as an important determinant of real wages in PNG.
Revealing the Dual Role of Ammonia in the Hydroxide Co‐Precipitation Synthesis of Cobalt‐Free Nickel‐Rich LiNi0.9Mn0.05Al0.05O2 (NMA955) Cathode Materials for Lithium‐Ion Batteries
Authors: Warman Jijim Fadilla , Karunawan Jotti , Floweri Octia , Suryadi Putri Nadia , Santosa Sigit Puji , Iskandar Ferry 
Published: November 2024

AbstractNickel‐rich cobalt‐free LiNi0.9Mn0.05Al0.05O2 (NMA955) is considered a promising cathode material to address the scarcity and soaring cost of cobalt. Particle size and elemental composition significantly impact the electrochemical performance of NMA955 cathodes. However, differences in precipitation rates among metal ions coveys a challenge in obtaining cathode materials with the desired particle size and composition via hydroxide co‐precipitation synthesis. Utilizing complexing agents like ammonia offers an effective strategy to tackle these issues. Here, we investigate the optimal ammonia concentration to achieve moderate particle size and precise material composition. Although ammonia only forms complex coordination with transition metals, its concentration also affects the final product's precipitation and composition, including aluminum. This study shows that ammonia serves a dual function in NMA synthesis via hydroxide co‐precipitation, i. e., regulating particle size and adjusting elemental composition. It was found that an ammonia concentration of 1.2 M achieved optimal particle size and composition, resulting in superior electrochemical performance. NMA955 synthesized in 1.2 M ammonia demonstrated a high specific capacity of 188.12 mAh g−1 at 0.1 C, retained 71.16 % of its capacity after 200 cycles at 0.2 C, and delivered 110.30 mAh g−1 at 5 C. These results suggest that tuning ammonia concentration is crucial for producing high‐performance cathode materials.
A Brief, Biased View of Neutron Star Cooling
Authors: Heinke Craig 
Published: November 2024

ABSTRACTThis is a concise and non‐technical review of topics related to neutron star (NS) cooling, for both young NSs and NSs in low‐mass x‐ray binaries. Neutrino emission from the NS core drives cooling rates, via different processes including Urca processes and pair breaking and formation at the neutron superfluid critical temperature. Key insights have been given by the temperatures of the coldest NSs, by the rapid (questioned) cooling of the Cas A NS, and by measuring the cooling of transient NS x‐ray binaries after accretion episodes.