bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Abordagem Effectuation em Empreendedorismo Social
Authors: Rocha Ronalty Oliveira , Silva Joenison Batista da , Teixeira Rivanda Meira , Montenegro Ludmilla Meyer 
Published: February 2019

Entendendo que o ambiente dos negócios sociais é repleto de incertezas e contingências e reconhecendo a importância das organizações sem fins lucrativos, que têm demonstrado serem atuantes para o bem-estar da coletividade, este estudo analisa a criação de empreendimentos sociais sob a abordagem Effectuation. Este trabalho pretendeu identificar como os princípios effectuation de definição de meios, perdas acessíveis, alianças estratégicas e alavancagem de contingências, propostos por Saravasthy (2001), formatam a criação de empreendimentos sociais. Para tanto foi realizado um estudo qualitativo de casos múltiplos, de natureza exploratória, em empreendimentos sociais de Sergipe. Os dados foram coletados por meio de entrevista semiestruturada com dois empreendedores sociais de Sergipe, e o conteúdo das entrevistas foi analisado com base na análise de conteúdo. Os resultados indicam que empreendedores sociais aplicam elementos de effectuation em seus negócios, principalmente a definição de meios, quando se envolvem em negócios a partir de suas características pessoais, profissionais e redes de contatos. A celebração de parcerias estratégicas, sem caráter formal, foi evidenciada como primordial à criação e continuidade de negócios sociais. Por fim, os princípios de perdas acessíveis e alavancagem de contingências foram os menos evidenciados nos casos.
Emerging Role of Mesenchymal Stem Cell-derived Exosomes in Regenerative Medicine
Authors: Zhao Ting , Sun Feng , Liu Jinwen , Ding Tianyan , She Jie , Mao Fei , Xu Wenrong , Qian Hui , Yan Yongmin 
Published: February 2019

Background:Recent studies have shown the great value of cell therapy over the past few decades. Mesenchymal stem cells (MSCs) have been reported to treat various degenerative diseases not through their differentiation potential but through their paracrine factors of the extracellular vesicle (EV) including exosomes. Exosomes are nanosized (70~150 nm) membrane-bound extracellular vesicles, not only involved in cell-to-cell communication but also in the development of tissue injury repair.Objective:As more researchers proved the enormous potential of exosomes in the field of repairing damaged tissue currently, it is urgent to explore the concrete mechanism and make exosomes to be a practical treatment tool in clinical medicine. In our study, we analyzed and summarized the work on tissue repair via exosomes in order to give some suggestions about the application of exosomes in clinical reality in the future.Results:MSC-derived exosomes (MSC-Ex) contain a wide variety of functional proteins, mRNAs, miRNAs and signaling lipids. Compared with their parent cells, MSC-Ex are more stable and can reduce the inherent safety risks in administering viable cells such as the risk of occlusion in microvasculature. MSC-Ex can be used to develop a cell-free exosome-based therapy for regenerative medicine, and may provide an alternative to MSC-based therapy.Conclusion:This review summarizes the most recent knowledge of therapeutic potential of MSC-Ex in the liver, heart, kidney, bone, brain diseases and cancer, as well as their associated challenges and opportunities.
Biomarkers in Non-Small Cell Lung Cancer: Perspectives of Individualized Targeted Therapy
Authors: Aoki Mateus N. , Amarante Marla K. , de Oliveira Carlos E.C. , Watanabe Maria A.E. 
Published: February 2019

Introduction:
The understanding of cancer has evolved into a complex disease, which has heterogeneous
characteristics between different patients, and more than that, a broad range of genetically distinct cells in
the same tumor. Chronic and non-transmissible diseases such as cancer have become even more important
worldwide and advances in their characterization and properties are running out. In a suitable setting, early
diagnosis of cancer and proper treatment are essential to overcome the barriers of tumor healing and quality
assurance of the patient's life. The studies included in the analysis were independently retrieved by the authors.
The text words included “Non-Small Cell Lung Cancer,” “NSCLC,” “biomarkers in NSCLC” and “gene in
NSCLC”.” We were used to perform a systematic literature search in the PubMed and Web of Science databases.
There was limit on the start date for published articles (2001), and the search ended in December 2017.
For a more comprehensive analysis, articles were only in English.

Non-small Cell Lung Cancer (NSCLC) Microenvironment:
This review focuses on lung cancer, especially NSCLC, one of the most worldwide common cancer types, showing the importance of tumor microenvironment
in this disease.

NSCLC Biomarkers:

This review shows a molecular aspect of NSCLC biomarkers used in clinical approaches,
such as EGFR, KRAS, MET, indicating mutations that are crucial for cancer progression and related to treatment
properties. We also describe 11 drugs commonly used in cancer treatment that are correlated with the patient
genetic profile.

Conclusion:
This review highlights the importance of molecular diagnosis of mutations in lung cancer, driving
to individualized therapy with the intent of getting a better response to treatment and improving patients’ quality
of life.
Hydrotalcite Clay+[TBA][OH] Ionic Liquid Combination for Selective Dihydroquinazolines
Authors: Srivastava Vivek 
Published: February 2019

Background:
We are submitting an easy, effective and environmentally benign protocol
for the synthesis of 18 different 1,2-dihydroquinazoline derivatives.

Methods:
We implemented [TMA][OH] ionic liquid mediated hydrotalcite clay catalytic system as a
green catalyst to perform this reaction.

Results:
Three-component reaction pathway was utilized to synthesize 1,2-dihydroquinazoline derivatives
using aromatic aldehydes, 2-amino benzophenones, and ammonium acetate with green and recyclable
ionic liquid mediated hydrotalcite clay catalytic system.

Conclusion:
The notable highlights of this method comprise short reaction time, operational simplicity,
high yields, and high selectivity. Additionally, the catalyst can be recovered and recycled for up
to eight cycles without any loss in catalytic activity.
Magnesium Based Biodegradable Metallic Implant Materials: Corrosion Control and Evaluation of Surface Coatings
Authors: Gayle Jessica , Mahapatro Anil 
Published: February 2019

Background:Magnesium and magnesium alloys are currently being explored for biodegradable metallic implants. Magnesium’s biocompatibility, low density, and mechanical properties could offer advantages in the development of low-bearing orthopedic prosthesis and cardiovascular stent materials.Objective:Magnesium’s susceptibility to corrosion and increased hydrogen evolution in vivo compromises the success of its potential applications. Various strategies have been pursued to control and subsequently evaluate degradation.Methods:This review provides a broad overview of magnesium-based implant materials. Potential coating materials, coating techniques, corrosion testing, and characterization methods for coated magnesium alloys are also discussed.Results:Various technologies and materials are available for coating magnesium to control and evaluate degradation. Polymeric, ceramic, metallic, and composite coatings have successfully been coated onto magnesium to control its corrosion behaviour. Several technologies are available to carry out the coatings and established methodologies exist for corrosion testing. A few magnesium-based products have emerged in international (European Union) markets and it is foreseen that similar products will be introduced in the United States in the near future.Conclusion:Overall, many coated magnesium materials for biomedical applications are predominantly in the research stage with cardiac stent materials and orthopaedic prosthesis making great strides.
PENGARUH NISBAH BAGI HASIL TERHADAP PREFERENSI MASYARAKAT MEMILIH PRODUK-PRODUK PENDANAAN PADA PERBANKAN SYARIAH DENGAN FAKTOR FINANCIAL LITERACY SEBAGAI VARIABEL INTERVENING
Authors: Irfayunita Febby , Miswardi Miswardi , Puteri Hesi Eka 
Published: February 2019

<p><em>This study investigates whether the profit-sharing system affects the preferences of choosing the funding product at Islamic Banks and if so , whether the effect is mediated by financial literacy. Using a sample of 385 customers of Islamic banks in Tanah Datar district, under condition 2018, this study reveals that the profit-sharing system and financial literacy is positively associated with the preferences of choosing funding products. This study proves that this association is significantly mediated by financial literacy. This finding offer the empirical evidence of the importance of financial literacy on the relationship between the profit-sharing system and the preferences of choosing the funding product. It indicates that the system of profit sharing in Islamic banks will not make people turn to Islamic banks without education of the Islamic financial system itself. Furthermore, this research recommends strategy of increasing market share of Islamic Bank by increasing public’s finance literacy</em></p><p>Studi ini mengalisis apakah sistem bagi hasil mempengaruhi preferensi memilih produk pendanaan di Bank syariah dan apakah dimediasi oleh literasi keuangan. Dengan menggunakan sampel 385 nasabah bank syariah di Kabupaten Tanah Datar, pada tahun 2018, penelitian ini mengungkapkan bahwa sistem bagi hasil dan literasi keuangan terkait secara positif dengan preferensi memilih produk pendanaan. Studi ini membuktikan bahwa asosiasi ini secara signifikan dimediasi oleh literasi keuangan. Temuan ini menawarkan bukti empiris tentang pentingnya literasi keuangan pada hubungan antara sistem bagi hasil dan preferensi memilih produk pendanaan. Ini menunjukkan bahwa sistem bagi hasil di bank syariah tidak akan membuat orang beralih ke bank syariah tanpa pendidikan dari sistem keuangan syariah itu sendiri. Selanjutnya, penelitian ini merekomendasikan strategi meningkatkan pangsa pasar Bank syariah dengan meningkatkan literasi keuangan publik.</p><p><em><br /></em></p>
Ideational Meanings of Teachers' Utterances in Reading and Writing Classes
Authors: Mulatsih Sri , Saleh Mursid , Warsono Warsono , Yuliasri Issy 
Published: February 2019

This study is aimed at describing the ideational meanings of teachers’ utterances in Reading and Writing classes. It reveals what processes, participants and circumstances are found in the teachers’ utterances. The data were taken from the Reading and Writing classes conducted at a university in Semarang city. The data were collected by video recording the teaching and learning processes in Reading and Writing classes, then they were analyzed by segmenting the utterances into clauses; identifying the process, participants, and circumstances; classifying the processes, participants and circumstances based on their type; and interpreting the data. The results showed that the processes mostly found in the teachers’ utterances in Reading class are relational ones with carrier and attribute as participants, the second are mental processes with senser and phenomenon as the participants, while in those of Writing class are material with actor and goal as participants and the second are relational with carrier and attribute as participants. Relational processes are dominant in Reading class because the teacher explained many terms or vocabularies found in the text to make the students really understand them. That material processes are dominant in Writing class is caused by the fact that in Writing class the teacher often asks the students to do some actions like writing or doing something.
Designing Multimedia-based Presentation in Academic Speaking Classroom
Authors: Sukma Denty Marga , Nurkamto Joko , Drajati Nur Arifah 
Published: February 2019

Educational technology is substantially aimed at assisting the teaching and learning process especially in material delivery that can be done using Powerpoint Presentation. Particularly, the integration of text-based material and a variety of media promote the likelihood that the audience experiences the effective information processing. Therefore, multimedia-based presentation that is accompanied by verbal explanation must be designed as effective as possible in order to foster the audience’s understanding. The current research was aimed at investigating the strategies employed by the students in designing multimedia-based presentation in Academic Speaking classroom. This qualitative research was carried out using case study approach to obtain the in-depth information. The data were collected through observation, document analysis, and interview. The results show that the students strategies in designing multimedia-based presentation are mainly to foster the audience’s thinking process. Those strategies are using heading to lead to thesis, using bullet list to create sequential delivery, and using the additional element to engage the audience. To make the slide gets into the logical manner, a transitional device is also required. This research will contribute to the teaching and learning process that uses presentation as the method of material delivery. The teacher and the student are expected to know the strategies to design an effective presentation that can promote the audience’s way to process the information.
Keyword: academic speaking, educational technology, information processing, material delivery, multimedia-based presentation
RISK FACTORS ON STUNTING AMONG CHILDREN AGE 2-5 YEARS OLD IN BIROMARU OF CENTER PUBLIC HEALTH
Authors: Imelda Imelda , Rahman Nurdin , Nur Rosmala 
Published: February 2019

Background & Objective: Stunted is a condition of disruption of growth in children caused by chronic malnutrition. Prevalence of stunting in Sigi regency is 45,20% (2015) and stunting incidence in Puskesmas Biromaru for children aged 2-5 are 60 cases (2017). This study aims to determine the risk factors of stunting events in children aged 2-5 years. Materials and Methods: Types of analytical survey research with Case Control design. Sampling method with total sampling and purposive sampling control sample based on certain consideration with ratio 1: 2, with case sample in this research as many as 60 children and control samples as much as 120, each sample is chosen based on age as matching. Stunting degree expressed by z-score height by age. Complete basic immunization data, feeding practice patterns, low birth weight and iodized salt obtained through interviews using a questionnaire and iodine test. The analysis used is the odd ratio with a significance level of 95%. Results: Complete basic immunization of OR 7,667 (95% CI 3,753-15,662), practice pattern of feeding OR 30,565 (95% CI 9.043-103,314), low birth weight OR 6,956 (95% CI 4,446-14,104) and iodized salt OR 8,632 (95% CI 4,268-17,456) is a risk factor for stunting events and has a significant relationship. Conclusion: Practice pattern of feeding is a major risk factor for stunting with OR 30,565
RISK FACTORS OF HYPERTENSION ADULT 20-44 YEARS AT COMMUNITY HEALTH CENTER OF KAWATUNA, CITY OF PALU
Authors: Puspitasari Ayu Astari 
Published: February 2019

Background & Objective: Hypertension is a serious public health problem that closes to a high prevalence. It has already killed 1.5 million people every year in South East Asia. Public health centre Kawatuna is public health centre which has the highest prevalence in 2006 from 13 public health centers in Palu. The study aims at finding out the habit of consuming fruits and vegetables, habit of consuming coffee, habit of smoking and BMI (Body Mass Index) as a risk factor of hypertension occurrence in the age of 20-44 years old in Public Health Centre Kawatuna Palu. Material and Methods: This was a case control study. Sample drawn for case group used total sampling whereas for control group used purposive sampling. Results: Consumption of fruits and vegetables was a risk factor for hypertension (OR = 3,381 (1,840-6,214)), coffee consumption was a risk factor for hypertension (OR = 2,234 (1,102-4,532)), BMI was a risk factor for hypertension (OR = 3,474 (1,820-6,629)) and smoking habits are risk factors for hypertension but not significant (OR = 1,725 (0,680-4,380)) . Conclusion: Habit of lack of consuming fruit and vegetable, habit of over consuming coffee and IMT >25 kg/m2 are the risk factors of hypertension occurrence
ANEMIA AND LOW BIRTH WEIGHT IN HOSPITAL OF ANUTAPURA PALU
Authors: Nur A. Fahira 
Published: February 2019

Background & Objective: Low Birth Weight (BBLR) is a major problem in the world, because it can lead to impaired fetal growth, so that the next generation of the nation will have an effect. This study aims to determine the association of anemia with low birth weight occurrence at hopstilal of Anutapura Palu. Material and Methods: The type of research used is quantitative with analytic observational design with Cross sectional approach. The number of samples is 91 respondents determined by Accidential sampling technique. Data analysis is che-square test with a significance level of p <0.05. Results: The results showed that pregnant women who were anemia were 72.5% and LBW was 40.7%. Severe anemia is 4.39%, moderate is 37.3%, and mild is 30.7%. Anemia level has a significant effect on birth weight (ρ = 0,000). Anemia has a significant relationship with the incidence of low birth weight (ρ = 0,000) at Hospital of Anutapura Palu . Conclusion: Anemia in pregnant women has a positive correlation with infant birth weight and is associated with the incidence of low birth weight
KORELASI UMUR DENGAN KADAR HEMATOKRIT, JUMLAH LEUKOSIT, DAN TROMBOSIT PASIEN INFEKSI VIRUS DENGUE
Authors: Jatmiko Safari Wahyu 
Published: February 2019

ABSTRAKInfeksi virus dengue (IVD) masih menjadi masalah di negara tropis dan sub tropis. Gejala IVD dan perubahan parameter hematologi seperti jumlah leukosit, trombosit dan kadar hematokrit. pada umumnya lebih berat pada pasien infeksi sekunder dengue virus (DENV) dengan serotipe yang berbeda. Risiko infeksi sekunder DENV meningkat seiring dengan bertambahnya usia. Hal ini menimbulkan landasan teori terhadap hipotesis bahwa semakin bertambah usia maka perubahan parameter hematologi semakin berat. Untuk menjawab hal tersebut dilakukan penelitian terhadap pasien IVD yang berusia dibawah 14 tahun dan memenuhi kriteria diagnostik WHO 2009. Diagnosis dikonfirmasi dengan IgG dan IgM antidengue. Hasil yang didapat adalah terdapat korelasi antara usia dengan kadar hematokrit dengan r = 0,248 dan p = 0,027 namun tidak ada korelasi antara usia dengan jumlah leukosit dengan r = 0,008 p = 0,943 dan trombosit dengan r -0,01 p = 0,929. Semakin bertambah usia maka semakin berat peningkatan kadar hematokrit pada anak penderita IVD.Kata kunci: Umur, Hematokrit, Leukosit, Trombosit, Infeksi Virus Dengue ABSTRACTDengue virus infection (IVD) is still a problem in tropical and sub-tropical countries. Symptoms of IVD and changes in hematological parameters such as the number of leukocytes, platelets and hematocrit levels are generally more severe in secondary DENV infections with different serotypes. The risk of secondary DENV infection increases with age. This raises the theoretical basis of the hypothesis that the older the worsening changes in hematologic parameters. To address this, a study of IVD patients under 14 years old and meeting the 2009 WHO diagnostic criteria is done. The diagnosis is confirmed by IgG and IgM antidengue. The result are correlation between age with hematocrit level with r = 0,248 and p = 0,027 but no correlation between age with leukocyte count with r = 0,008 p = 0,943 and platelet with r -0,01 p = 0,929. It can be concluded that the more aged the more severe the increase in hematocrit levels in children with IVD.Keywords: Age, Hematocrit, Leukocyte, Platelet, Dengue Virus Infection
HUBUNGAN DERAJAT KEPRIBADIAN INTROVERT DENGAN SINDROMA PRAMENSTRUASI
Authors: Bestari Rochmadina Suci 
Published: February 2019

Introvert people tend to have distress. Psicosomatic manifestation from distress on women can be appeared as premenstrual syndrome. The aim of this study is to know the correlation between social introversion stage and premenstrual syndrome. This study is an analitic observasional study with cross sectional approach, which was held on November 2006 on Medical Faculty UNS Solo. Samples were taken by purposive sampling with restriction on new university studentsclass 2006 Medical Faculty of UNS. The requirements are : (1) on premenstrual or menstrual phase, and (2) does not have reproduction organ disease. Subject ﬁ lled (1) Kuesioner Riwayat Menstruasi dan Ginekologi (Gynecology and Menstrual History Questionair) to know subject’s menstrual cycle, (2) Kuesioner Skala L-MMPI (L-MMPI Scale Questionair) to state honesty in answering questions given, (3) Kuesioner Sindroma Pramenstruasi (Premenstrual Syndrome Questionair) consisted of pramenstrual syndrome’s aspects, (4) Kuesioner Skala-0 MMPI (MMPI 0-Scale Questionair) to state social introversion stage. It’s obtained 42 subjects data. Social introversion stage (SI) and premenstrual syndrome (PMS) data were then analyzed with (1) Normality test by Shapiro Wilk, and (2) Hypothetic test by Pearson correlation used SPSS 11.0 for Windows computer program.Results of this study are (1) Premenstrual subjects are bigger amount than non-premenstrual subjects (88,1% vs 11,9%), (2) there is signiﬁ cant positive correlation between social introversion stage and premenstrual syndrome with strong correlation (r=0,551; P<0,05). The conclusion of this study is there is signiﬁ cant positive correlation between social introversion stage and premenstrual syndrome.Keywords: Social introversion, premenstrual syndrome