bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Neutrophil Gelatinase-Associated Lipocalin in Children with Sydenham's Chorea Accompanying Valvular Regurgitation
Authors: Deveci Köksal , Guven Ahmet , Alaygut Demet , Oflaz Mehmet 
Published: July 2018

Background Acute rheumatic fever (ARF) is a nonsuppurative complications of Group A β-hemolytic streptococcal (GABHS) infection due to a delayed immune response. Sydenham's chorea (SC) is an important neurological manifestation of ARF, and heart involvement is seen in a large proportion of patients with SC. The immune system has a crucial role in initiating and spreading inflammation, which causes tissue damage in ARF.
Aim The purpose of this study was to investigate urine neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for kidney injury in children with rheumatic chorea accompanying valvular involvement.
Materials and Methods Twenty-eight consecutive children with SC accompanying evidence of valvular involvement, and 30 nonrheumatic, age- and sex-matched healthy children were included in the study. Cardiac evaluations were performed, and urinary NGAL, micro-total protein and creatinine levels were measured in all participants.
Results Age, gender, weight, and height were similar in the patients and controls. Twenty-three patients had isolated mitral regurgitation, and five patients had mitral and aortic regurgitation. While there was no statistically significant difference between the urine creatinine and micro-total protein levels in patients and controls, the patient group demonstrated a significantly higher mean urine NGAL level (18.01 ± 7.9 vs. 3.22 ± 1.4, p = 0.002) and mean urine NGAL/creatinine ratio (2.80 ± 1.9 vs. 0.33 ± 0.1, p = 0.008). However, there were no correlations between severity of chorea and urinary NGAL or urinary NGAL/creatinine ratio, there were significant positive correlations between severity of valvular regurgitation and urinary NGAL (r = 0.751, p < 0.001) and urinary NGAL/creatinine ratio (r = 0.694, p < 0.001).
Conclusion The present study revealed that urinary NGAL level and urinary NGAL/creatinine ratio were higher in patients with SC accompanying valvular involvement. The results obtained from this study suggest that ARF may cause subclinical renal injury in patients with intense and prolonged cellular immune response leading to chorea and carditis.
Giant and explosive plasmonic bubbles by delayed nucleation
Authors: Wang Yuliang , Zaytsev Mikhail E. , Lajoinie Guillaume , The Hai Le , Eijkel Jan C. T. , van den Berg Albert , Versluis Michel , Weckhuysen Bert M. , Zhang Xuehua , Zandvliet Harold J. W. , Lohse Detlef 
Published: July 2018

SignificancePlasmonic microbubbles are at the center of numerous applications, including micromanipulation/nanomanipulation, biomedical diagnosis and therapy, and solar energy harvesting. Controlling the dynamics of these microbubbles is key to successfully exploiting their potential in the growing number of applications. Literature has vastly overlooked the nucleation and early microsecond dynamics by which these microbubbles arise. It is of utmost importance to understand this early phase, as it displays the most violent dynamics and is the precursor and origin of all subsequent dynamics, on which the many applications rely.
Human Serum With High Neutralizing Antibody Titers Against Both Zika and Dengue Virus Shows Delayed In Vitro Antibody-Dependent Enhancement of Dengue Virus Infection
Authors: Valiant William G , Lalani Tahaniyat , Yun Heather C , Kunz Anjali , Burgess Timothy H , Mattapallil Joseph J 
Published: July 2018

Abstract
Zika virus infection in a dengue virus–naïve subject was associated with the induction of high levels of cross-reactive binding antibodies. These responses were, however, largely non-neutralizing and displayed a capacity to enhance dengue infection in vitro at significantly low dilution (1:10). In contrast, a subject who had high levels of neutralizing antibodies against both dengue and Zika viruses enhanced infection at a dilution of 1:10 000. These results suggest that high levels of dengue cross-neutralizing antibodies could potentially prevent the enhancement of dengue infection in Zika virus–convalescent individuals.
Social History of Medicine and Disability History
Authors: Kudlick Catherine 
Published: July 2018

Abstract
Disability history and social history of medicine are two subfields that share many common topics and sources but that approach them very differently. For medical historians, disability takes center stage as a problem that requires fixing, and the “victims” are primarily patients. For disability historians, disability suggests not just the person or practitioner, but also a unique understanding of all the elements, including politics, economics, and culture, that shape relationships for the disabled. Following a brief history of each subfield, two examples are presented—responses to epidemics and the idea of cure—to discuss how scholars can be in more productive conversation. As is demonstrated here, disability is not just a topic to be studied, but rather a tool of analysis. While the distinctive roots and purposes of the two subfields ensure that they will always be fundamentally incompatible, they can, and should, engage in productive conversation.
Race, Work, and Disability in Progressive Era United States
Authors: Lawrie Paul 
Published: July 2018

Abstract
Throughout U.S. history, the production of difference, whether along racial or disability lines, has been inextricably tied to the imperatives of labor economy. From the plantations of the antebellum era through the assembly lines and trenches of early-twentieth-century America, ideologies of race and disability have delineated which peoples could do which kinds of work. The ideologies and identities of race, work, and the “fit” ’ or “unfit” body informed Progressive Era labor economies. Here the processes of racializing or disabling certain bodies are charted from turn-of-the-century actuarial science, which monetized blacks as a degenerate, dying race, through the standardized physical and mental testing and rehabilitation methods developed by the U.S. army during World War I. Efforts to quantify, poke, prod, or mend black bodies reshaped contemporary understandings of labor, race, the state, and the working body.
Material Culture, Technology, and the Body in Disability History
Authors: Ott Katherine 
Published: July 2018

Abstract
Disability is created, measured, and supported through material culture. Technology, a kind of material culture, has an especially close relationship with disability in that it both supports daily activities and is often a primary element in defining who is of worth or qualifies as human. Some of the unique and complicated ways in which disability and material culture interact and intersect are presented here, highlighting such things as sensory and nonverbal information, material expression of inclusion and accessibility, definitions of technology, the prevalence of do-it-yourself solutions, and ideologies of assistance and independence. Also discussed is the use of two broad functions of technology, objects of activity and objects of worth, as an entry point into critical disability studies analysis.
Agenda Setting and Bounded Rationality
Authors: Jones Bryan D. , McGee Zachary A. 
Published: July 2018

Abstract
This chapter reviews the existing scholarship on agenda setting, focusing on two aspects of human choice. The first aspect centers on behavioral analyses of choice, especially cognitive limits to rationality (e.g., limits to the human attention span, the process of satisficing, and the use of heuristics), directed at understanding how individuals prioritize action. The second aspect focuses on organizational choice, with an emphasis on the impacts of information processing, search processes, and organizational structure. The chapter examines linkages between micro and macro processes, showing how studies of organizations and broader political systems based on a model of comprehensive rationality fail. Focusing on behavioral foundations allows for a more accurate and holistic explanation of issue prioritization (agenda setting) in complex organizations based on behavioral models of choice. The chapter concludes with suggestions for future directions of research.
Henri de Lubac
Authors: Flynn Gabriel 
Published: July 2018

Abstract
This chapter provides an interpretative framework for understanding de Lubac’s ecclesiology. It first reconstructs key elements in his vision of the church within his overarching view of a ‘total’ ecclesiology. De Lubac’s vision of ‘totality’ provides a hermeneutical key to interpret his thought on the church and is considered in the context of his contribution to the renewed theology of the ‘mystical body’, the fruits of which have been garnered since Vatican II under the appellation ‘communion ecclesiology’. The second major section expounds de Lubac’s profoundly Eucharistic ecclesiology and shows how it provides a spiritual and social vision for the contemporary world.
Joseph Ratzinger
Authors: Dieter Theodor 
Published: July 2018

Abstract
Ratzinger’s ecclesiology is a Eucharistic ecclesiology: the church is the people of God existing from the sacramental Body of Christ and thus becoming the ecclesial Body of Christ. Therefore the church is communio: the communion at the table with Christ and among the believers, and also a communion of local churches (communio ecclesiarum) that is the basis for the collegiality of the bishops. The spiritual and institutional dimensions of the Body of Christ are mutually interwoven. In every particular church the universal church is present; its representation and the point of reference in doctrinal matters for all is the pope. The church serves the presence of the Word of God in the world in such a way that the Word as it is witnessed to in Holy Scripture is communicated to all by authorized witnesses. Witness (content) and witnesses are inseparable, as succession and tradition are mutually interrelated as form and content.
Incorporating Innovative Simulation Activities Into Campus Lab to Enhance Skill Competence and Critical Thinking of Second-Semester Associate Degree Nursing Students
Authors: Andrew Lesley A. , Baxter Patricia M. 
Published: July 2018

Abstract
Decreasing access to clinical sites, inconsistency in student learning experiences, and lack of faculty have compelled nursing schools to incorporate more simulation into their curricula. Professional organizations, regulating bodies, and schools of nursing support its use. The Nursing 2 Challenge simulation activity was designed to give second-semester nursing students an opportunity to improve skill competence and critical thinking utilizing a systematic, preplanned station rotation format in the safe setting of the nursing campus lab. Each station required the students to apply clinical decision-making and nursing skills to complete interventions aligned with course objectives.
Social Marketing Campaigns as a Teaching Strategy for Health Promotion
Authors: Unterseher Lindsey 
Published: July 2018

Abstract
Current nursing students are more technologically adept than past generations; they are accustomed to using technology in their everyday life. Proficiency in technology is a major asset, and as such, nursing education should provide for opportunities with technology that will support future practice. This article reports on a group project effectively used to capitalize on this skill while encouraging active engagement in learning about health promotion. Student groups created a social marketing campaign consisting of a summary of their campaign, one infogram, and one 30-second video focused on a topic area from Healthy People 2020.
An Innovative Approach to Onboarding and Supporting Adjunct Faculty in Nursing
Authors: Kemery Dana C. , Serembus Joanne Farley 
Published: July 2018

Abstract
In recent years, online graduate nursing programs throughout the United States have seen unprecedented growth that has resulted in a greater need for adjunct faculty who can adequately teach in an online format. Frequently, adjunct faculty are not prepared to teach online as they are not offered the necessary continued support in their roles. Through the development of an onboarding program, barriers for teaching online were eliminated. The program is supported by a faculty learning community and continuous professional development workshops. These resources support adjunct faculty at various stages of their professional development and allow for collaborative exchange.
Association Between Attempted External Cephalic Version and Perinatal Morbidity and Mortality
Authors: Son Moeun , Roy Archana , Grobman William A. , Miller Emily S. 
Published: July 2018

OBJECTIVE:
To examine whether, with fetal malpresentation at term, perinatal morbidity and mortality differ between women who undergo an external cephalic version (ECV) attempt and those who do not and are expectantly managed.

METHODS:
We conducted a retrospective cohort study of women with nonanomalous singleton gestations in nonvertex presentation delivering at a tertiary care institution from 2006 to 2016. Women undergoing an ECV attempt at 37 weeks of gestation or greater were compared with those with nonvertex fetuses who did not undergo an ECV attempt and delivered at 37 weeks of gestation or greater. The primary outcome was a composite of perinatal morbidity and mortality including stillbirth, neonatal death within 72 hours, Apgar score less than 5 at 5 minutes, umbilical artery pH less than 7.0, base deficit 12 mmol/L or greater, or neonatal therapeutic hypothermia. Secondary outcomes were neonatal intensive care unit admission and neonatal anemia (hemoglobin value less than 13.5 g/dL). Bivariable and multivariable analyses were performed.

RESULTS:
Of the 4,117 women meeting eligibility criteria, 1,263 (30.7%) attempted ECV; 509 (40.3%) of these attempts resulted in successful versions. In bivariable analyses, women who underwent attempted ECV were more likely to be non-Hispanic white and multiparous and had lower mean body mass indexes. The composite perinatal morbidity and mortality outcome did not differ significantly between women who did and did not undergo attempted ECV (2.9% vs 2.5%, P=.46). The frequencies of neonatal intensive care unit admission (3.6% vs 3.3%, P=.53) and neonatal anemia (1.6% vs 1.2%, P=.36) were also similar. There continued to be no association between ECV attempt and composite perinatal morbidity and mortality outcome after adjustment for potential confounders (adjusted odds ratio 1.02, 95% CI 0.66–1.60).

CONCLUSION:
Compared with expectant management, an ECV attempt at term is not associated with increased perinatal morbidity or mortality.
Female Sexual Dysfunction and the Placebo Effect
Authors: Weinberger James M. , Houman Justin , Caron Ashley T. , Patel Devin N. , Baskin Avi S. , Ackerman A. Lenore , Eilber Karyn S. , Anger Jennifer T. 
Published: July 2018

OBJECTIVE:
To quantify the placebo effect of various pharmacologic modalities including neuromodulators, hormonal agents, and onabotulinum toxin A for female sexual dysfunction.

DATA SOURCES:
Using Meta-analyses Of Observational Studies in Epidemiology guidelines, we conducted a systematic review of PubMed, EMBASE, ClinicalTrials.gov, and the Cochrane Review databases.

METHODS OF STUDY SELECTION:
Eleven search terms, “female sexual dysfunction” “treatment” in combination with “hypoactive sexual desire,” “arousal disorder,” “sexual pain disorder,” “genitourinary syndrome of menopause,” “orgasmic disorder,” “vulvovaginal atrophy,” “vaginismus,” “vaginal atrophy,” “vulvodynia,” and “vestibulitis,” were used. Studies were included if their design was randomized, included a placebo arm, and used the Female Sexual Function Index as an outcome measure.

TABULATION, INTEGRATION, AND RESULTS:
The placebo effect on the Female Sexual Function Index was compared with each respective study's treatment effect using inverse-variance weighting in a random-effects analysis model. Six hundred five relevant articles were retrieved. Twenty-four randomized controlled trials included a placebo arm. Of these, eight studies used the Female Sexual Function Index. Across these studies, 1,723 women with clinical pretreatment female sexual dysfunction received placebo. Two thousand two hundred thirty-six women were in the treatment arm of the respective studies and received various pharmacologic interventions including flibanserin, bupropion, onabotulinum toxin A, intravaginal prasterone, intranasal oxytocin, ospemifene, and bremelanotide. Women receiving placebo improved 3.62 (95% CI 3.29–3.94) on the Female Sexual Function Index. The treatment arm had a corresponding increase of 5.35 (95% CI 4.13–6.57).

CONCLUSION:
This meta-analysis of Level I evidence demonstrates that 67.7% of the treatment effect for female sexual dysfunction is accounted for by placebo. Our findings suggest that the current treatments for female sexual dysfunction are, overall, minimally superior to placebo, which emphasizes the ongoing need for more efficacious treatment for female sexual dysfunction.
Institutional Protocols for Vaginal Preparation With Antiseptic Solution and Surgical Site Infection Rate in Women Undergoing Cesarean Delivery During Labor
Authors: La Rosa Mauricio , Jauk Victoria , Saade George , Boggess Kim , Longo Sherri , Clark Erin A. S. , Esplin Sean , Cleary Kirsten , Wapner Ronald , Letson Kellett , Owens Michelle Y. , Blackwell Sean , Szychowski Jeff M. , Andrews William W. , Tita Alan T. ,   for the Cesarean Section Optimal Antibiotic Prophylaxis Trial Consortium
Published: July 2018

OBJECTIVE:
To evaluate the association of institutional protocols for vaginal preparation with antiseptic solution and the surgical site infection rate in women undergoing cesarean delivery during labor.

METHODS:
This is a secondary analysis of a multicenter randomized controlled trial of adjunctive azithromycin prophylaxis for cesarean delivery performed in laboring patients with viable pregnancies. The primary outcome for this analysis was the rate of superficial or deep surgical site infection within 6 weeks postpartum, as per Centers for Disease Control and Prevention criteria. Maternal secondary outcomes included a composite of endometritis, wound infection or other infections, postoperative maternal fever, length of hospital stay, and the rates of hospital readmission, unexpected office visits, and emergency department visits.

RESULTS:
A total of 523 women delivered in institutions with vaginal antisepsis policies before cesarean delivery and 1,490 delivered in institutions without such policies. There was no difference in superficial and deep surgical site infection rates between women with and without vaginal preparation (5.5% vs 4.1%; odds ratio [OR] 1.38, 95% CI 0.87–2.17), even after adjusting for possible confounders (adjusted OR 0.86, 95% CI 0.43–1.73). The lack of significant benefit was noted in all other maternal secondary outcomes.

CONCLUSION:
Institutional policies for vaginal preparation before cesarean delivery were not associated with lower rates of surgical site infection in women undergoing cesarean delivery during labor.
Immunotherapy-based combinations: an update
Authors: Fucà Giovanni , de Braud Filippo , Di Nicola Massimo 
Published: July 2018

Purpose of review
The advent of immunotherapy significantly improved clinical outcomes in cancer patients, although immune checkpoint blockade (ICB) still lack of efficacy in a consistent proportion of treated patients. The purpose of this article is to review the most innovative and clinically promising ICB-based combinations designed to improve the efficacy of cancer immunotherapy.

Recent findings
First-line combinatorial treatment with ipilimumab and nivolumab has recently shown to be superior to the standard of care in a subset of metastatic nonsmall cell lung cancer (NSCLC) and renal cell carcinoma (RCC). The combination of programmed cell death protein 1 (PD-1)/PD-L1 blockade with antiangiogenics has demonstrated a consistent clinical efficacy, especially for the combination of bevacizumab and atezolizumab as first-line therapy in metastatic RCC. The sequential combination of definitive chemoradiotherapy followed by durvalumab maintenance in advanced, unresectable NSCLC became the new standard of care, while the addition of pembrolizumab to first-line chemotherapy in metastatic NSCLC significantly improves overall survival. Despite promising results for the combination of ICBs with v-raf murine sarcoma viral oncogene homolog B/MAPK/ERK kinase inhibitors or epidermal growth factor receptor inhibitors, especially in melanoma and NSCLC, safety concerns slowed down the development of such strategies.

Summary
Immunotherapy-based combinations are becoming the standard of care for cancer treatment, in particularly for advanced melanoma, NSCLC and RCC.
Effectiveness of Animal-Assisted Therapy in the Pediatric Population: Systematic Review and Meta-Analysis of Controlled Studies
Authors: Charry-Sánchez Jesús David , Pradilla Iván , Talero-Gutiérrez Claudia 
Published: July 2018

ABSTRACT:

Objective:
To synthesize the results of controlled studies evaluating the effectiveness of animal-assisted therapy (AAT) in children.

Methods:
Eleven databases were searched following the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement recommendations, and references from included studies and previous reviews were examined. No date or language filters were applied. Only controlled study designs, including those using wait-list controls, that studied a specific condition or illness were included. Study quality was assessed using the Cochrane Risk of Bias Tool.

Results:
Twenty-six studies that met the inclusion criteria were retrieved. Nine were conducted in children with autism spectrum disorders, 10 in cerebral palsy (CP), 2 in Down syndrome, 3 in pain, and 2 in other conditions. Qualitative synthesis showed a small but significant contribution of AAT to the management of these conditions. Meta-analysis showed a mean difference in improvement in the Gross Motor Function Measure-66 scale in children with CP of 1.61 (95% confidence interval [CI] −2.00 to 5.23) and a mean difference for 5-point pain scales of −0.81 (95% CI −1.32 to 0.30), both favoring AAT.

Conclusion:
Animal-assisted therapy may be useful as a complementary intervention in the management of children with CP and pain. Although results are in general positive for the management of children with Down syndrome and autism, the diversity of scales used to measure outcomes makes it difficult to establish true effectiveness. The application of simple corrective measures in the randomization process would greatly improve the quality of evidence. It is necessary to reach a consensus between AAT researchers regarding appropriate instruments to provide higher-quality evidence in further studies.